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Sample records for commissioner reorganization statement

  1. 75 FR 7490 - Office of the Commissioner Reorganization; Statement of Organizations, Functions, and Delegations...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ... to agency programs, strategies and activities, including preparation of special reports for the... analysis activities. 3. Develops program and planning strategy through analysis and evaluation of issues... provides global telecommunications (secure voice, facsimile and data communications) capability...

  2. Concurring Statement In Re: Children's Television Report.

    ERIC Educational Resources Information Center

    Hooks, Benjamin L.

    1974-01-01

    Three Federal Communications Commissioners (FCC) filed supplementary statements to the FCC Children's Television Report, elaborating on their individual views. Commissioner Benjamin L. Hooks concurred in the proposed limit on commercial minutes in children's programs, but suggested a lower figure. He also suggested that commercials be…

  3. 47 CFR 0.381 - Defense Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Defense Commissioner. 0.381 Section 0.381... National Security and Emergency Preparedness Delegations § 0.381 Defense Commissioner. The authority delegated to the Commission under Executive Orders 12472 and 12656 is redelegated to the...

  4. 47 CFR 0.381 - Defense Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Defense Commissioner. 0.381 Section 0.381... National Security and Emergency Preparedness Delegations § 0.381 Defense Commissioner. The authority delegated to the Commission under Executive Orders 12472 and 12656 is redelegated to the...

  5. 47 CFR 0.381 - Defense Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Defense Commissioner. 0.381 Section 0.381... National Security and Emergency Preparedness Delegations § 0.381 Defense Commissioner. The authority delegated to the Commission under Executive Orders 12472 and 12656 is redelegated to the...

  6. 47 CFR 0.381 - Defense Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Defense Commissioner. 0.381 Section 0.381... National Security and Emergency Preparedness Delegations § 0.381 Defense Commissioner. The authority delegated to the Commission under Executive Orders 12472 and 12656 is redelegated to the...

  7. 47 CFR 0.381 - Defense Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Defense Commissioner. 0.381 Section 0.381... National Security and Emergency Preparedness Delegations § 0.381 Defense Commissioner. The authority delegated to the Commission under Executive Orders 12472 and 12656 is redelegated to the...

  8. The Leadership Proficiency of Commissioners of Agriculture

    ERIC Educational Resources Information Center

    Baughman, Kristen N.; Bruce, Jacklyn

    2012-01-01

    The purpose of this mixed methods study was to determine the self-perceived proficiency level of Commissioners of Agriculture in six leadership skill areas. Major findings noted their proficiency in these areas. Researchers recommend providing professional development opportunities and software training for Commissioners at their annual…

  9. School District Reorganization: Can Small Schools Compete? A Position Paper.

    ERIC Educational Resources Information Center

    Mack, David P.; Lederman, Alfred T.

    The following position statements regarding school reorganization are discussed in chapter-by-chapter sequence within the paper: (1) It is the responsibility of all schools, regardless of size, to prepare students adequately to live full and productive lives in a rapidly changing world. (2) In New York State, school district reorganization, while…

  10. 47 CFR 0.181 - The Defense Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false The Defense Commissioner. 0.181 Section 0.181..., Defense and Emergency Preparedness Functions § 0.181 The Defense Commissioner. The Defense Commissioner is designated by the Commission. The Defense Commissioner directs the homeland security, national security...

  11. 47 CFR 0.181 - The Defense Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false The Defense Commissioner. 0.181 Section 0.181..., Defense and Emergency Preparedness Functions § 0.181 The Defense Commissioner. The Defense Commissioner is designated by the Commission. The Defense Commissioner directs the homeland security, national security...

  12. Wind Energy Guide for County Commissioners

    EPA Pesticide Factsheets

    This report provides county commissioners, planners, and other local county government officials with a practical overview of information required to successfully implement commercial wind energy projects in their county.

  13. Public policy involvement by health commissioners.

    PubMed

    Thompson, Amy; Boardley, Debra; Kerr, Dianne; Greene, Tiffany; Jenkins, Melissa

    2009-08-01

    The purpose of this national study was to determine advocacy activities and level of involvement of health commissioners regarding public policy. Benefits, barriers, and perceived outcomes of advocacy efforts were also explored. A previously validated (Holtrop et al., Am J Health Behav 24(2):132-142, 2000) four-page survey was mailed to 700 health commissioners, who were randomly selected from the National Association of County and City Health Officials (NACCHO) database. A three-wave mailing was performed which yielded a 50% response rate. Of these respondents, the majority (70%) were female and (88%) Caucasian. Overall, 31% of health commissioners reported being involved in influencing public policy in the last 4 years. The most common reported activities engaged in by health commissioners included voting (84%), and providing policy information to consumers or other professionals (77%). Perceived barriers to influencing policy were time, (64%), and other priorities (46%). Perceived benefits to influencing policy included improving the health of the public (94%) and making a difference in others' lives (87%). Only 15% perceived their knowledge regarding the process of changing public policy was excellent. Although health commissioners are often spokespersons for health agencies and communities, their public policy involvement is marginal. Professional preparation programs and continuing education opportunities should focus on advocacy, public policy development, and removing barriers to action.

  14. Assessing New York's Commissioner of Education

    ERIC Educational Resources Information Center

    Meyer, Peter

    2011-01-01

    In this article, the author talks about the resignation of New York State's commissioner of education David Steiner, and how it will affect the state's Race to the Top. He contends that Steiner was savvy enough to understand the importance of Race to the Top and able enough to turn the state's education energies toward it. The "Washington…

  15. 24 CFR 200.21 - Reinsurance of Commissioner held mortgages.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Reinsurance of Commissioner held mortgages. 200.21 Section 200.21 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance § 200.21 Reinsurance of Commissioner held mortgages. Any mortgage assigned to the Commissioner...

  16. Data Reorganization Interface

    DTIC Science & Technology

    2007-11-02

    Data Reorganization Interface Kenneth Cain Mercury Computer Systems, Inc. Phone: (978)-967-1645 Email Address: kcain@mc.com Abstract...6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Mercury Computer Systems...18 © 2003 Mercury Computer Systems, Inc. Data Reorganization Interface (DRI) Kenneth Cain Jr. Mercury Computer Systems, Inc. High Performance

  17. 16 CFR 802.10 - Stock dividends and splits; reorganizations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Stock dividends and splits; reorganizations. 802.10 Section 802.10 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 EXEMPTION RULES § 802.10...

  18. 16 CFR 802.10 - Stock dividends and splits; reorganizations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Stock dividends and splits; reorganizations. 802.10 Section 802.10 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 EXEMPTION RULES § 802.10...

  19. 16 CFR 802.10 - Stock dividends and splits; reorganizations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Stock dividends and splits; reorganizations. 802.10 Section 802.10 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 EXEMPTION RULES § 802.10...

  20. 16 CFR 802.10 - Stock dividends and splits; reorganizations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Stock dividends and splits; reorganizations. 802.10 Section 802.10 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 EXEMPTION RULES § 802.10...

  1. 16 CFR 802.10 - Stock dividends and splits; reorganizations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Stock dividends and splits; reorganizations. 802.10 Section 802.10 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 EXEMPTION RULES § 802.10...

  2. Unions and Workplace Reorganization.

    ERIC Educational Resources Information Center

    Nissen, Bruce, Ed.

    The 11 chapters in this book focus on "The New American Workplace" and assess its adequacy or inadequacy as a guide for the U.S. labor movement in relation to new work systems. "Unions and Workplace Reorganization" (Bruce Nissen) introduces the subject. "The New American Workplace: A Labor Perspective" (AFL-CIO Committee on the Evolution of Work,…

  3. BIA Reorganization Task Force

    ERIC Educational Resources Information Center

    American Indian Journal, 1978

    1978-01-01

    Reporting on three hearings held this spring by the Bureau of Indian Affairs Reorganization Task Force, this article presents highlights from the testimony of Forrest Gerard, Assistant Secretary for Indian Affairs and discusses the matrix system of organization currently under consideration by the BIA. (JC)

  4. 19 CFR 12.42 - Findings of Commissioner of Customs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Findings of Commissioner of Customs. 12.42 Section 12.42 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT... Labor § 12.42 Findings of Commissioner of Customs. (a) If any port director or other principal...

  5. 24 CFR 207.257 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Commissioner's right to require acceleration. 207.257 Section 207.257 Housing and Urban Development Regulations Relating to Housing and Urban... Mortgagee Under the Contract of Insurance § 207.257 Commissioner's right to require acceleration....

  6. 24 CFR 232.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Commissioner's right to require acceleration. 232.860 Section 232.860 Housing and Urban Development Regulations Relating to Housing and Urban... of Insurance § 232.860 Commissioner's right to require acceleration. Upon receipt of notice of...

  7. 24 CFR 232.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Commissioner's right to require acceleration. 232.860 Section 232.860 Housing and Urban Development Regulations Relating to Housing and Urban... of Insurance § 232.860 Commissioner's right to require acceleration. Upon receipt of notice of...

  8. 24 CFR 241.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Commissioner's right to require acceleration. 241.860 Section 241.860 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance § 241.860 Commissioner's right to require acceleration. Upon receipt of notice of the failure...

  9. 24 CFR 241.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Commissioner's right to require acceleration. 241.860 Section 241.860 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance § 241.860 Commissioner's right to require acceleration. Upon receipt of notice of the failure...

  10. 24 CFR 241.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Commissioner's right to require acceleration. 241.860 Section 241.860 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance § 241.860 Commissioner's right to require acceleration. Upon receipt of notice of the failure...

  11. 24 CFR 232.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Commissioner's right to require acceleration. 232.860 Section 232.860 Housing and Urban Development Regulations Relating to Housing and Urban... of Insurance § 232.860 Commissioner's right to require acceleration. Upon receipt of notice of...

  12. 24 CFR 232.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Commissioner's right to require acceleration. 232.860 Section 232.860 Housing and Urban Development Regulations Relating to Housing and Urban... of Insurance § 232.860 Commissioner's right to require acceleration. Upon receipt of notice of...

  13. 24 CFR 241.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Commissioner's right to require acceleration. 241.860 Section 241.860 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance § 241.860 Commissioner's right to require acceleration. Upon receipt of notice of the failure...

  14. 24 CFR 232.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Commissioner's right to require acceleration. 232.860 Section 232.860 Housing and Urban Development Regulations Relating to Housing and Urban... of Insurance § 232.860 Commissioner's right to require acceleration. Upon receipt of notice of...

  15. 24 CFR 241.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Commissioner's right to require acceleration. 241.860 Section 241.860 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance § 241.860 Commissioner's right to require acceleration. Upon receipt of notice of the failure...

  16. 20 CFR 498.222 - Final decision of the Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Final decision of the Commissioner. 498.222 Section 498.222 Employees' Benefits SOCIAL SECURITY ADMINISTRATION CIVIL MONETARY PENALTIES, ASSESSMENTS AND RECOMMENDED EXCLUSIONS § 498.222 Final decision of the Commissioner. (a) Except with respect...

  17. 47 CFR 0.181 - The Defense Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Organization Homeland Security... designated by the Commission. The Defense Commissioner directs the homeland security, national security and emergency preparedness, and defense activities of the Commission and has the following duties...

  18. 45 CFR 1321.31 - Appeal to Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.31 Appeal to Commissioner....

  19. 45 CFR 1321.31 - Appeal to Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.31 Appeal to Commissioner....

  20. 45 CFR 1321.31 - Appeal to Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.31 Appeal to Commissioner....

  1. 45 CFR 1321.31 - Appeal to Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.31 Appeal to Commissioner....

  2. 45 CFR 1321.31 - Appeal to Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.31 Appeal to Commissioner....

  3. SITE DEMONSTRATION OF THE TORONTO HARBOUR COMMISSIONERS SOIL RECYCLING PROJECT

    EPA Science Inventory

    The U.S. Environmental Protection Agency (EPA), in cooperation with the Toronto Harbour Commissioners (THC), conducted a Superfund InnovativeTechnology Evaluation (SITE) demonstration of the THC Soil Recycle Treatment Train. The treatment train consists of three technologies op...

  4. Wind Energy Guide for County Commissioners

    SciTech Connect

    Costanti, M.

    2006-10-01

    One of the key stakeholders associated with economic development are local government officials, who are often required to evaluate and vote on commercial wind energy project permits, as well as to determine and articulate what wind energy benefits accrue to their counties. Often these local officials lack experience with large-scale wind energy and need to make important decisions concerning what may be a complicated and controversial issue. These decisions can be confounded with diverse perspectives from various stakeholders. This project is designed to provide county commissioners, planners, and other local county government officials with a practical overview of information required to successfully implement commercial wind energy projects in their county. The guidebook provides readers with information on the following 13 topics: Brief Wind Energy Overview; Environmental Benefits; Wind Energy Myths and Facts; Economic Development Benefits; Wind Economics; The Development Process; Public Outreach; Siting Issues; Property Tax Incentives; Power System Impacts; Permitting, Zoning, and Siting Processes; Case Studies; and Further Information. For each of the above topics, the guidebook provides an introduction that identifies the topic, why local government should care, a topic snapshot, how the topic will arise, and a list of resources that define and assess the topic.

  5. Decentralization in the New York City Department of Health: reorganization of a public health agency.

    PubMed Central

    Mustalish, A C; Eidsvold, G; Novick, L F

    1976-01-01

    Since the World War I era there has existed within the New York City Department of Health a basic internal struggle between staff directing the bureaus at the central office and the district health officers operating field health centers throughout the city. Recently, in a five-year period, there was a dramatic reorganization of the Department which markedly affected its orientation and programs. In 1972 a new Commissioner initiated a reorganization of the Department which succeeded in decentralizing field operations in contrast to earlier efforts which had failed to reach this objective. The roles of bureaus and districts were redefined, with the latter receiving budgetary authority, authority to supervise personnel, assignment of health managers, and the implementation of a district cost accounting system. While operational decentralization has occurred, policy setting and resource allocation in response to local needs remain central functions. PMID:795307

  6. A theoretical description of charge reorganization energies in molecular organic P-type semiconductors.

    PubMed

    Brückner, Charlotte; Engels, Bernd

    2016-06-05

    Charge transport properties of materials composed of small organic molecules are important for numerous optoelectronic applications. A material's ability to transport charges is considerably influenced by the charge reorganization energies of the composing molecules. Hence, predictions about charge-transport properties of organic materials deserve reliable statements about these charge reorganization energies. However, using density functional theory which is mostly used for the predictions, the computed reorganization energies depend strongly on the chosen functional. To gain insight, a benchmark of various density functionals for the accurate calculation of charge reorganization energies is presented. A correlation between the charge reorganization energies and the ionization potentials is found which suggests applying IP-tuning to obtain reliable values for charge reorganization energies. According to benchmark investigations with IP-EOM-CCSD single-point calculations, the tuned functionals provide indeed more reliable charge reorganization energies. Among the standard functionals, ωB97X-D and SOGGA11X yield accurate charge reorganization energies in comparison with IP-EOM-CCSD values. © 2016 Wiley Periodicals, Inc.

  7. 24 CFR 207.257 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Commissioner's right to require acceleration. 207.257 Section 207.257 Housing and Urban Development Regulations Relating to Housing and...

  8. 24 CFR 207.257 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Commissioner's right to require acceleration. 207.257 Section 207.257 Housing and Urban Development Regulations Relating to Housing and...

  9. 24 CFR 207.257 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Commissioner's right to require acceleration. 207.257 Section 207.257 Housing and Urban Development Regulations Relating to Housing and...

  10. 24 CFR 207.257 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Commissioner's right to require acceleration. 207.257 Section 207.257 Housing and Urban Development Regulations Relating to Housing and...

  11. 24 CFR 220.813 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... AUTHORITIES MORTGAGE INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Commissioner's right to require acceleration. 220.813 Section 220.813 Housing and Urban Development Regulations Relating to Housing and...

  12. 24 CFR 220.813 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... AUTHORITIES MORTGAGE INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Commissioner's right to require acceleration. 220.813 Section 220.813 Housing and Urban Development Regulations Relating to Housing and...

  13. 24 CFR 220.813 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... AUTHORITIES MORTGAGE INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Commissioner's right to require acceleration. 220.813 Section 220.813 Housing and Urban Development Regulations Relating to Housing and...

  14. 24 CFR 220.813 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... AUTHORITIES MORTGAGE INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Commissioner's right to require acceleration. 220.813 Section 220.813 Housing and Urban Development Regulations Relating to Housing and...

  15. 4. DETAIL OF BUILDER'S PLATES: '1901, CARTER H. HARRISON, COMMISSIONER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. DETAIL OF BUILDER'S PLATES: '1901, CARTER H. HARRISON, COMMISSIONER OF PUBLIC WORKS, MAYOR F.W. BLOCKI, JOHN ERICSON, CITY ENGINEER'; 'FITZSIMONS AND CONNELL CO. SUBSTRUCTURE'; 'AMERICAN BRIDGE COMPANY, LASSIG PLANT, CONTRACTOR FOR SUPERSTRUCTURE' - Chicago River Bascule Bridge, West Cortland Street, Spanning North Branch of Chicago River at West Cortland Street, Chicago, Cook County, IL

  16. 19 CFR 115.17 - Appeal to Commissioner of Customs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Appeal to Commissioner of Customs. 115.17 Section 115.17 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL...

  17. 24 CFR 220.813 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AUTHORITIES MORTGAGE INSURANCE AND INSURED IMPROVEMENT LOANS FOR URBAN RENEWAL AND CONCENTRATED DEVELOPMENT... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Commissioner's right to require acceleration. 220.813 Section 220.813 Housing and Urban Development Regulations Relating to Housing and...

  18. FCC Commissioner, Legal Assistant and Staff Perceptions of Cable TV.

    ERIC Educational Resources Information Center

    Krugman, Dean M.

    1979-01-01

    Describes a methodology used in interviewing Federal Communications Commission commissioners, legal assistants, and Cable Bureau staff members about their attitudes toward the cable industry and regulation; reports results of the interviews, noting respondents' disappointment in the lack of cable growth. (GT)

  19. 21 CFR 570.15 - Adoption of regulation on initiative of Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 6 2011-04-01 2011-04-01 false Adoption of regulation on initiative of Commissioner. 570.15 Section 570.15 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Adoption of regulation on initiative of Commissioner. (a) The Commissioner upon his own initiative...

  20. 21 CFR 570.15 - Adoption of regulation on initiative of Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Adoption of regulation on initiative of Commissioner. 570.15 Section 570.15 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Adoption of regulation on initiative of Commissioner. (a) The Commissioner upon his own initiative...

  1. 21 CFR 170.15 - Adoption of regulation on initiative of Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 3 2012-04-01 2012-04-01 false Adoption of regulation on initiative of Commissioner. 170.15 Section 170.15 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Adoption of regulation on initiative of Commissioner. (a) The Commissioner upon his own initiative...

  2. 21 CFR 170.15 - Adoption of regulation on initiative of Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 3 2011-04-01 2011-04-01 false Adoption of regulation on initiative of Commissioner. 170.15 Section 170.15 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Adoption of regulation on initiative of Commissioner. (a) The Commissioner upon his own initiative...

  3. 21 CFR 570.15 - Adoption of regulation on initiative of Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 6 2012-04-01 2012-04-01 false Adoption of regulation on initiative of Commissioner. 570.15 Section 570.15 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Adoption of regulation on initiative of Commissioner. (a) The Commissioner upon his own initiative...

  4. 21 CFR 170.15 - Adoption of regulation on initiative of Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Adoption of regulation on initiative of Commissioner. 170.15 Section 170.15 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Adoption of regulation on initiative of Commissioner. (a) The Commissioner upon his own initiative...

  5. 21 CFR 570.15 - Adoption of regulation on initiative of Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Adoption of regulation on initiative of Commissioner. 570.15 Section 570.15 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Adoption of regulation on initiative of Commissioner. (a) The Commissioner upon his own initiative...

  6. 21 CFR 570.15 - Adoption of regulation on initiative of Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Adoption of regulation on initiative of Commissioner. 570.15 Section 570.15 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Adoption of regulation on initiative of Commissioner. (a) The Commissioner upon his own initiative...

  7. 21 CFR 170.15 - Adoption of regulation on initiative of Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 3 2013-04-01 2013-04-01 false Adoption of regulation on initiative of Commissioner. 170.15 Section 170.15 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Adoption of regulation on initiative of Commissioner. (a) The Commissioner upon his own initiative...

  8. 17 CFR 140.11 - Emergency action by the senior Commissioner available.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Emergency action by the senior... the senior Commissioner available. (a) Authority of senior Commissioner. When it is not feasible to convene a quorum of the Commission, the Senior Commissioner present at the principal offices of...

  9. Reorganizing SOF for Irregular Warfare

    DTIC Science & Technology

    2008-12-01

    after the Soviet Union launched Sputnik in 1957, the creation of the Environmental Protection Agency ( EPA ) in 1970, and the most recent reorganization...elliptical orbit some 550 miles above a Cold War-wracked planet. For the moment, at least, communism had trumped capitalism on a major front, and the

  10. The Commissioner's Annual Report: Submitted to the Congress by the Commissioner of Education in Accordance with Sec. 412. (b) of P. L. 91-230.

    ERIC Educational Resources Information Center

    Marland, S. P., Jr.

    An accounting is made in this report of the work of the Office of the Commissioner of Education during Fiscal Year 1970 and reflects the state of American education today. The Commissioner envisions the Federal role in education to be one of increasing the effectiveness of the human and financial resources of our schools, colleges and…

  11. Dynamic reorganization of river basins.

    PubMed

    Willett, Sean D; McCoy, Scott W; Perron, J Taylor; Goren, Liran; Chen, Chia-Yu

    2014-03-07

    River networks evolve as migrating drainage divides reshape river basins and change network topology by capture of river channels. We demonstrate that a characteristic metric of river network geometry gauges the horizontal motion of drainage divides. Assessing this metric throughout a landscape maps the dynamic states of entire river networks, revealing diverse conditions: Drainage divides in the Loess Plateau of China appear stationary; the young topography of Taiwan has migrating divides driving adjustment of major basins; and rivers draining the ancient landscape of the southeastern United States are reorganizing in response to escarpment retreat and coastal advance. The ability to measure the dynamic reorganization of river basins presents opportunities to examine landscape-scale interactions among tectonics, erosion, and ecology.

  12. Reorganization: premises, processes, and pitfalls.

    PubMed Central

    Jacobson, S

    1994-01-01

    As the technological environment changes and libraries assume new and more active roles in their institutions, the traditional library hierarchy ceases to be an effective organizational structure. Guided by theories that emphasize teamwork, quality, and employee empowerment and participation, libraries are developing flatter, more networked organizations. The Health Sciences Library at Columbia University in New York, New York, recently underwent a reorganization in an effort to become a more resilient, more flexible organization. The process was beneficial overall. While some errors and confusion occurred, these are seen as opportunities for learning and evidence of the library's new atmosphere of creativity and experimentation. PMID:7841904

  13. Commission on Child Online Protection (COPA) Report to Congress [and] Personal Statements of COPA Commissioners.

    ERIC Educational Resources Information Center

    2000

    In October, 1998, Congress enacted the Child Online Protection Act and established the Commission on Online Child Protection (COPA) to study methods to help reduce access by minors to certain sexually explicit material, defined in the statute as harmful to minors. Congress directed the Commission to evaluate the accessibility, cost, and…

  14. 28 CFR 16.201 - Voting by the Commissioners without joint deliberation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Commissioners without joint deliberation. (a) Whenever the Commission's Chairman so directs, any matter which (1) does not appear to require joint deliberation among the members of the Commission, or (2) by reason of... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Voting by the Commissioners without...

  15. 26 CFR 36.3121(l)(4)-1 - Termination of agreement by Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ....3121(l)(4)-1 Section 36.3121(l)(4)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... OF FOREIGN SUBSIDIARIES § 36.3121(l)(4)-1 Termination of agreement by Commissioner. (a) Notice of....3121(l)(1)-1 is in effect may be terminated by the Commissioner, with the prior concurrence of...

  16. 26 CFR 36.3121(l)(4)-1 - Termination of agreement by Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ....3121(l)(4)-1 Section 36.3121(l)(4)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... OF FOREIGN SUBSIDIARIES § 36.3121(l)(4)-1 Termination of agreement by Commissioner. (a) Notice of....3121(l)(1)-1 is in effect may be terminated by the Commissioner, with the prior concurrence of...

  17. 26 CFR 36.3121(l)(4)-1 - Termination of agreement by Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ....3121(l)(4)-1 Section 36.3121(l)(4)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... OF FOREIGN SUBSIDIARIES § 36.3121(l)(4)-1 Termination of agreement by Commissioner. (a) Notice of....3121(l)(1)-1 is in effect may be terminated by the Commissioner, with the prior concurrence of...

  18. 26 CFR 36.3121(l)(4)-1 - Termination of agreement by Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ....3121(l)(4)-1 Section 36.3121(l)(4)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... OF FOREIGN SUBSIDIARIES § 36.3121(l)(4)-1 Termination of agreement by Commissioner. (a) Notice of....3121(l)(1)-1 is in effect may be terminated by the Commissioner, with the prior concurrence of...

  19. 26 CFR 36.3121(l)(4)-1 - Termination of agreement by Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ....3121(l)(4)-1 Section 36.3121(l)(4)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... OF FOREIGN SUBSIDIARIES § 36.3121(l)(4)-1 Termination of agreement by Commissioner. (a) Notice of....3121(l)(1)-1 is in effect may be terminated by the Commissioner, with the prior concurrence of...

  20. 24 CFR 203.315 - Termination by conveyance to other than Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Termination by conveyance to other than Commissioner. 203.315 Section 203.315 Housing and Urban Development Regulations Relating...

  1. 24 CFR 207.259a - Waiver of title objection; mortgages formerly Commissioner-held.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Waiver of title objection; mortgages formerly Commissioner-held. 207.259a Section 207.259a Housing and Urban Development...

  2. 24 CFR 207.259a - Waiver of title objection; mortgages formerly Commissioner-held.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Waiver of title objection; mortgages formerly Commissioner-held. 207.259a Section 207.259a Housing and Urban Development...

  3. 24 CFR 203.315 - Termination by conveyance to other than Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Termination by conveyance to other than Commissioner. 203.315 Section 203.315 Housing and Urban Development Regulations Relating...

  4. 24 CFR 203.315 - Termination by conveyance to other than Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Termination by conveyance to other than Commissioner. 203.315 Section 203.315 Housing and Urban Development Regulations Relating...

  5. 24 CFR 207.259a - Waiver of title objection; mortgages formerly Commissioner-held.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Waiver of title objection; mortgages formerly Commissioner-held. 207.259a Section 207.259a Housing and Urban Development...

  6. 24 CFR 203.315 - Termination by conveyance to other than Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Termination by conveyance to other than Commissioner. 203.315 Section 203.315 Housing and Urban Development Regulations Relating...

  7. 24 CFR 203.315 - Termination by conveyance to other than Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Termination by conveyance to other than Commissioner. 203.315 Section 203.315 Housing and Urban Development Regulations Relating...

  8. Commissioner's Roundtable for Women in Educational Leadership in Florida. Proceedings (Tallahassee, Florida, November 20, 1991).

    ERIC Educational Resources Information Center

    Florida State Dept. of Education, Tallahassee.

    The proceedings of this roundtable discuss the current status of Florida women in educational leadership and ways to expand their opportunities for advancement. The report begins with an introduction and opening remarks by Florida's Assistant Commissioner of Education, Laurey T. Stryker and Florida Commissioner of Education, Betty Castor. A…

  9. 28 CFR 0.98 - Functions of Commissioner of Federal Prison Industries.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Prison Industries. 0.98 Section 0.98 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Bureau of Prisons § 0.98 Functions of Commissioner of Federal Prison Industries. The Director of the Bureau of Prisons is authorized as ex officio Commissioner of Federal Prison Industries...

  10. 28 CFR 0.98 - Functions of Commissioner of Federal Prison Industries.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Prison Industries. 0.98 Section 0.98 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Bureau of Prisons § 0.98 Functions of Commissioner of Federal Prison Industries. The Director of the Bureau of Prisons is authorized as ex officio Commissioner of Federal Prison Industries...

  11. 28 CFR 0.98 - Functions of Commissioner of Federal Prison Industries.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Prison Industries. 0.98 Section 0.98 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Bureau of Prisons § 0.98 Functions of Commissioner of Federal Prison Industries. The Director of the Bureau of Prisons is authorized as ex officio Commissioner of Federal Prison Industries...

  12. Lansing Community College Reorganization Overview Document.

    ERIC Educational Resources Information Center

    Lansing Community Coll., MI.

    In response to an unstable economy and diminishing resources, Lansing Community College, in Michigan, initiated a college-wide reorganization in July 1993 to improve institutional effectiveness and increase efficiency. This paper provides a description of the reorganization process and organizational structure before and after the change. First, a…

  13. Massive cortical reorganization in sighted Braille readers.

    PubMed

    Siuda-Krzywicka, Katarzyna; Bola, Łukasz; Paplińska, Małgorzata; Sumera, Ewa; Jednoróg, Katarzyna; Marchewka, Artur; Śliwińska, Magdalena W; Amedi, Amir; Szwed, Marcin

    2016-03-15

    The brain is capable of large-scale reorganization in blindness or after massive injury. Such reorganization crosses the division into separate sensory cortices (visual, somatosensory...). As its result, the visual cortex of the blind becomes active during tactile Braille reading. Although the possibility of such reorganization in the normal, adult brain has been raised, definitive evidence has been lacking. Here, we demonstrate such extensive reorganization in normal, sighted adults who learned Braille while their brain activity was investigated with fMRI and transcranial magnetic stimulation (TMS). Subjects showed enhanced activity for tactile reading in the visual cortex, including the visual word form area (VWFA) that was modulated by their Braille reading speed and strengthened resting-state connectivity between visual and somatosensory cortices. Moreover, TMS disruption of VWFA activity decreased their tactile reading accuracy. Our results indicate that large-scale reorganization is a viable mechanism recruited when learning complex skills.

  14. A Statement

    ERIC Educational Resources Information Center

    Mondale, Walter F.

    1973-01-01

    Article is a statement by Senator Walter F. Mondale, a Democrat from Minnesota, on the evaluation of social programs and a serious appraisal of social policy for the nation's children and their families. (Author/RK)

  15. Reorganization for intravenous procedures in dentistry.

    PubMed

    Litchfield, N B

    1975-08-01

    The importance of reorganization for intravenous dental procedures, involving not only premises and equipment but also the dentist and his staff, is emphasised. These matters are discussed in detail with special emphasis on certain essential factors and psychologic aspects.

  16. PDGF induces reorganization of vimentin filaments.

    PubMed

    Valgeirsdóttir, S; Claesson-Welsh, L; Bongcam-Rudloff, E; Hellman, U; Westermark, B; Heldin, C H

    1998-07-30

    In this study we demonstrate that stimulation with platelet-derived growth factor (PDGF) leads to a marked reorganization of the vimentin filaments in porcine aortic endothelial (PAE) cells ectopically expressing the PDGF beta-receptor. Within 20 minutes after stimulation, the well-spread fine fibrillar vimentin was reorganized as the filaments aggregated into a dense coil around the nucleus. The solubility of vimentin upon Nonidet-P40-extraction of cells decreased considerably after PDGF stimulation, indicating that PDGF caused a redistribution of vimentin to a less soluble compartment. In addition, an increased tyrosine phosphorylation of vimentin was observed. The redistribution of vimentin was not a direct consequence of its tyrosine phosphorylation, since treatment of cells with an inhibitor for the cytoplasmic tyrosine kinase Src, attenuated phosphorylation but not redistribution of vimentin. These changes in the distribution of vimentin occurred in conjunction with reorganization of actin filaments. In PAE cells expressing a Y740/751F mutant receptor that is unable to bind and activate phosphatidylinositol 3'-kinase (PI3-kinase), the distribution of vimentin was virtually unaffected by PDGF stimulation. Thus, PI3-kinase is important for vimentin reorganization, in addition to its previously demonstrated role in actin reorganization. The small GTPase Rac has previously been shown to be involved downstream of PI3-kinase in the reorganization of actin filaments. In PAE cells overexpressing dominant negative Rac1 (N17Rac1), no change in the fine fibrillar vimentin network was seen after PDGF-BB stimulation, whereas in PAE cells overexpressing constitutively active Rac1 (V12Rac1), there was a dramatic change in vimentin filament organization independent of PDGF stimulation. These data indicate that PDGF causes a reorganization of microfilaments as well as intermediate filaments in its target cells and suggest an important role for Rac downstream of PI3-kinase in

  17. 76 FR 5799 - Notice of Commissioners and Staff Attendance at FERC Leadership Development Program Induction...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... Energy Regulatory Commission Notice of Commissioners and Staff Attendance at FERC Leadership Development...: FERC Leadership Development Program Induction Ceremony: 888 First Street, NE., Washington, DC 20426... Leadership Development Program. Kimberly D. Bose, Secretary. BILLING CODE 6717-01-P...

  18. 77 FR 44609 - Notice of Commissioner and Staff Attendance at the National Association of Regulatory Utility...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... Regulatory Utility Commissioners 2012 Summer Committee Meetings The Federal Energy Regulatory Commission... found at http://summer.narucmeetings.org/agenda.cfm The discussions at these meetings, which are open...

  19. TECHNOLOGY EVALUATION REPORT: TORONTO HARBOUR COMMISSIONERS (THC) SOIL RECYCLE TREATMENT TRAIN. Project Summary

    EPA Science Inventory

    A demonstration of the Toronto Harbour Commissioners' (THC) Soil Recycle Treatment Train was performed under the Superfund Innovative Technology Evaluation (SITE) Program at a pilot plant facility in Toronto, Ontario, Canada. The Soil Recycle Treatment Train, which consists of s...

  20. TUESDAY: EPA Administrator to Address National Association of Regulatory Utility Commissioners

    EPA Pesticide Factsheets

    WASHINGTON- On Tuesday, U.S. Environmental Protection Agency (EPA) Administrator Gina McCarthy will deliver remarks at the National Association of Regulatory Utility Commissioners' Winter Committee Meetings in Washington, DC. Administrator McCarthy

  1. 12 CFR 575.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Mutual holding company reorganizations. 575.3... COMPANIES § 575.3 Mutual holding company reorganizations. A mutual savings association may reorganize to become a mutual holding company, or join in a mutual holding company reorganization as an...

  2. 12 CFR 575.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 6 2013-01-01 2012-01-01 true Mutual holding company reorganizations. 575.3... COMPANIES § 575.3 Mutual holding company reorganizations. A mutual savings association may reorganize to become a mutual holding company, or join in a mutual holding company reorganization as an...

  3. 12 CFR 575.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Mutual holding company reorganizations. 575.3... COMPANIES § 575.3 Mutual holding company reorganizations. A mutual savings association may reorganize to become a mutual holding company, or join in a mutual holding company reorganization as an...

  4. 12 CFR 575.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Mutual holding company reorganizations. 575.3... COMPANIES § 575.3 Mutual holding company reorganizations. A mutual savings association may reorganize to become a mutual holding company, or join in a mutual holding company reorganization as an...

  5. 12 CFR 575.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 6 2012-01-01 2012-01-01 false Mutual holding company reorganizations. 575.3... COMPANIES § 575.3 Mutual holding company reorganizations. A mutual savings association may reorganize to become a mutual holding company, or join in a mutual holding company reorganization as an...

  6. 76 FR 71919 - Corporate Reorganizations; Allocation of Basis in “All Cash D” Reorganizations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-21

    ...In the Rules and Regulations section of this issue of the Federal Register, the IRS is issuing temporary regulations that provide guidance regarding the determination of the basis of stock or securities in a reorganization where no stock or securities of the issuing corporation is issued and distributed in the transaction. These regulations clarify that, in certain reorganizations where no......

  7. Massive cortical reorganization in sighted Braille readers

    PubMed Central

    Siuda-Krzywicka, Katarzyna; Bola, Łukasz; Paplińska, Małgorzata; Sumera, Ewa; Jednoróg, Katarzyna; Marchewka, Artur; Śliwińska, Magdalena W; Amedi, Amir; Szwed, Marcin

    2016-01-01

    The brain is capable of large-scale reorganization in blindness or after massive injury. Such reorganization crosses the division into separate sensory cortices (visual, somatosensory...). As its result, the visual cortex of the blind becomes active during tactile Braille reading. Although the possibility of such reorganization in the normal, adult brain has been raised, definitive evidence has been lacking. Here, we demonstrate such extensive reorganization in normal, sighted adults who learned Braille while their brain activity was investigated with fMRI and transcranial magnetic stimulation (TMS). Subjects showed enhanced activity for tactile reading in the visual cortex, including the visual word form area (VWFA) that was modulated by their Braille reading speed and strengthened resting-state connectivity between visual and somatosensory cortices. Moreover, TMS disruption of VWFA activity decreased their tactile reading accuracy. Our results indicate that large-scale reorganization is a viable mechanism recruited when learning complex skills. DOI: http://dx.doi.org/10.7554/eLife.10762.001 PMID:26976813

  8. Reorganizing the nursing home industry: a proposal.

    PubMed

    Shulman, D; Galanter, R

    1976-01-01

    This paper proposes a reorganization of the nursing home industry with capital facilities owned by government, but with management conducted through a system of competitive contracts with the private sector. The paper explicity demonstrates in real estate finance terms how the present system of private ownership of capital facilities inherently impedes providing a high quality of care. The authors believe that in the proposed industry reorganization, market forces, instead of working against quality care, would be supportive of quality care in a framework that would involve generally less regulation than exists today.

  9. REORGANIZED SCIENCE CURRICULUM, K, KINDERGARTEN SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THIS VOLUME PROVIDES THE KINDERGARTEN TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. A CHART INDICATES CONCEPTS TO BE TAUGHT IN GRADES K-3 FOR EACH OF THE FOUR AREAS AROUND WHICH THE PROGRAM IS DESIGNED. THE AREAS ARE (1) THE…

  10. REORGANIZED SCIENCE CURRICULUM, 1, GRADE ONE SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE SECOND IN A SERIES OF17 VOLUMES, THIS VOLUME PROVIDES THE FIRST GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. A CHART INDICATES CONCEPT TO BE TAUGHT IN GRADES K-3 FOR EACH OF THE FOUR AREAS AROUND WHICH THE PROGRAM…

  11. REORGANIZED SCIENCE CURRICULUM, 2, GRADE TWO SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE THIRD IN A SERIES OF 17 VOLUMES, THIS VOLUME PROVIDES THE SECOND GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. A CHART INDICATES CONCEPTS TO BE TAUGHT IN GRADES K-3, IN EACH OF THE FOUR AREAS AROUND WHICH THE PROGRAM…

  12. REORGANIZED SCIENCE CURRICULUM, 3, GRADE THREE SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE FOURTH IN A SERIES OF 17 VOLUMES, THIS VOLUME PROVIDES THE THIRD GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. A CHART INDICATES CONCEPTS TO BE TAUGHT IN GRADES K-3 FOR EACH OF THE FOUR AREAS AROUND WHICH THE PROGRAM…

  13. COMMUNITY CONFLICT RELATED TO SCHOOL DISTRICT REORGANIZATION.

    ERIC Educational Resources Information Center

    JONASSEN, CHRISTEN T.

    NORMATIVE SOCIAL AND CULTURAL FACTORS RELATING TO THE PROCESS OF SCHOOL REDISTRICTING AND CONSOLIDATION WERE IDENTIFIED AND DESCRIBED, AND SOME OF THE INTERRELATIONSHIPS BETWEEN THESE FACTORS DETERMINED. SUCH DATA COULD BE USED DURING A SCHOOL DISTRICT REORGANIZATION PROCESS BY BOTH EDUCATORS AND ADMINISTRATORS TO MINIMIZE TENSION AND MITIGATE THE…

  14. Upgrading the U.S. Workplace: Do Reorganization, Education Help?

    ERIC Educational Resources Information Center

    Bassi, Laurie J.

    1995-01-01

    Surveys of companies involved in reorganization found that firms that establish workplace education programs and reorganize work report noticeable improvements in their employees' abilities and the quality of their products. (Author)

  15. 12 CFR 575.4 - Grounds for disapproval of reorganizations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... resources. Failure by a reorganizing association and any acquiree association to submit a business plan in connection with a Reorganization Notice, or submission of a business plan that projects activities that are... materially, from the business plan submitted in connection with the Reorganization Notice, unless...

  16. 12 CFR 239.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 4 2014-01-01 2014-01-01 false Mutual holding company reorganizations. 239.3... RESERVE SYSTEM (CONTINUED) MUTUAL HOLDING COMPANIES (REGULATION MM) Mutual Holding Companies § 239.3 Mutual holding company reorganizations. (a) A mutual savings association may not reorganize to become...

  17. 12 CFR 239.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Mutual holding company reorganizations. 239.3... RESERVE SYSTEM (CONTINUED) MUTUAL HOLDING COMPANIES (REGULATION MM) Mutual Holding Companies § 239.3 Mutual holding company reorganizations. (a) A mutual savings association may not reorganize to become...

  18. 12 CFR 239.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 4 2012-01-01 2012-01-01 false Mutual holding company reorganizations. 239.3... RESERVE SYSTEM (CONTINUED) MUTUAL HOLDING COMPANIES (REGULATION MM) Mutual Holding Companies § 239.3 Mutual holding company reorganizations. (a) A mutual savings association may not reorganize to become...

  19. Seafloor Spreading Reorganization South of Iceland

    NASA Astrophysics Data System (ADS)

    Hey, R. N.; Martinez, F.; Benediktsdottir, A.; Hoskuldsson, A.

    2011-12-01

    There is a major ongoing diachronous reorganization of North Atlantic seafloor spreading occurring at present south of Iceland, from an orthogonal ridge/transform geometry to the present oblique spreading geometry without transform faults on the Reykjanes Ridge. This reorganization is presently interpreted as a thermal phenomenon, with a pulse of warmer mantle expanding away from the Iceland plume causing a progressive change in subaxial mantle rheology from brittle to ductile, so that transform faults can no longer be maintained. Given that this is certainly the most obvious and arguably the type-example of active plate boundary reorganization, it is somewhat surprising that a thermal mechanism has near universal acceptance here whereas most if not all other seafloor spreading reorganizations are equally universally thought to result from the tectonic rift propagation mechanism. This suggests the possibility that either the thermal model might be wrong here, or that the propagating rift (PR) model might be wrong elsewhere. The reason the PR alternative was ignored here was that the younger seafloor record flanking the Reykjanes Ridge consisting of V-shaped ridges, troughs & scarps (VSRs) enclosed by the reorganization wake seemed to prove that there had been no rift propagation. It had long been thought that these VSRs were symmetric about the spreading axis, & if this conventional wisdom (that led directly to the pulsing Iceland plume model) were true, rift propagation, which must produce asymmetry, could not have occurred. However, our expedition collected marine geophysical data that showed that the VSRs actually have an asymmetric geometry consistent with rift propagation, not with previous pulsing plume models, & thus they can no longer be considered convincing proof of a pulsing Iceland plume. Although we had previously noted that plume pulses might drive the propagators away from Iceland, a significant new result (Benediktsdóttir et al., 2011) is that

  20. 78 FR 54455 - Permanent Advisory Committee to Advise the U.S. Commissioners to the Western and Central Pacific...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-04

    ... Committee (PAC) to advise the U.S. Commissioners to the Western and Central Pacific Fisheries Commission... section of this notice. DATES: The meeting of the PAC will be held on October 28, 2013, from 8 a.m. to 4 p... consultation with the U.S. Commissioners to the WCPFC, has appointed a Permanent Advisory Committee or PAC...

  1. 76 FR 34220 - Commissioners of Public Works of the City of Spartanburg, SC; Notice of Application for Surrender...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-13

    ... Energy Regulatory Commission Commissioners of Public Works of the City of Spartanburg, SC; Notice of..., 2010 and supplemented on May 19, 2011. d. Applicant: Commissioners of Public Works of the City of... that the following application has been filed with the Commission and is available for...

  2. 75 FR 2126 - Clifton Power Corporation; Commissioner of Public Works of the City of Spartanburg, SC; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Clifton Power Corporation; Commissioner of Public Works of the City of... Intervene January 7, 2010. On November 4, 2009, Commissioner of Public Works of the City of...

  3. Active biopolymers confer fast reorganization kinetics.

    PubMed

    Swanson, Douglas; Wingreen, Ned S

    2011-11-18

    Many cytoskeletal biopolymers are "active," consuming energy in large quantities. In this Letter, we identify a fundamental difference between active polymers and passive, equilibrium polymers: for equal mean lengths, active polymers can reorganize faster than equilibrium polymers. We show that equilibrium polymers are intrinsically limited to linear scaling between mean lifetime (or mean first-passage time, or MFPT) and mean length, MFPT∼, by analogy to 1D Potts models. By contrast, we present a simple active-polymer model that improves upon this scaling, such that MFPT∼(1/2). Since, to be biologically useful, structural biopolymers must typically be many monomers long yet respond dynamically to the needs of the cell, the difference in reorganization kinetics may help to justify the active polymers' greater energy cost.

  4. 17 CFR 200.43 - Disposition of business by exercise of authority delegated to individual Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... exercise of authority delegated to individual Commissioner. 200.43 Section 200.43 Commodity and Securities... Disposition of Commission Business § 200.43 Disposition of business by exercise of authority delegated to... Commission; Provided, however, That no such delegation shall authorize the duty officer (i) to exercise...

  5. 17 CFR 200.43 - Disposition of business by exercise of authority delegated to individual Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... exercise of authority delegated to individual Commissioner. 200.43 Section 200.43 Commodity and Securities... Disposition of Commission Business § 200.43 Disposition of business by exercise of authority delegated to... Commission; Provided, however, That no such delegation shall authorize the duty officer (i) to exercise...

  6. 17 CFR 200.43 - Disposition of business by exercise of authority delegated to individual Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... exercise of authority delegated to individual Commissioner. 200.43 Section 200.43 Commodity and Securities... Disposition of Commission Business § 200.43 Disposition of business by exercise of authority delegated to... Commission; Provided, however, That no such delegation shall authorize the duty officer (i) to exercise...

  7. 20 CFR 702.105 - Use of the title District Director in place of Deputy Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Use of the title District Director in place of Deputy Commissioner. 702.105 Section 702.105 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR LONGSHOREMEN'S AND HARBOR WORKERS' COMPENSATION ACT AND RELATED...

  8. 20 CFR 702.105 - Use of the title District Director in place of Deputy Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Use of the title District Director in place of Deputy Commissioner. 702.105 Section 702.105 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR LONGSHOREMEN'S AND HARBOR WORKERS' COMPENSATION ACT AND RELATED...

  9. 20 CFR 702.105 - Use of the title District Director in place of Deputy Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Use of the title District Director in place of Deputy Commissioner. 702.105 Section 702.105 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR LONGSHOREMEN'S AND HARBOR WORKERS' COMPENSATION ACT AND RELATED...

  10. 20 CFR 702.105 - Use of the title District Director in place of Deputy Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Use of the title District Director in place of Deputy Commissioner. 702.105 Section 702.105 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR LONGSHOREMEN'S AND HARBOR WORKERS' COMPENSATION ACT AND RELATED...

  11. 20 CFR 702.105 - Use of the title District Director in place of Deputy Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Use of the title District Director in place of Deputy Commissioner. 702.105 Section 702.105 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR LONGSHOREMEN'S AND HARBOR WORKERS' COMPENSATION ACT AND RELATED...

  12. 24 CFR 203.320 - Notice and date of termination by Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Notice and date of termination by Commissioner. 203.320 Section 203.320 Housing and Urban Development Regulations Relating to Housing and...

  13. 24 CFR 203.320 - Notice and date of termination by Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Notice and date of termination by Commissioner. 203.320 Section 203.320 Housing and Urban Development Regulations Relating to Housing and...

  14. 24 CFR 207.256 - Notice to the Commissioner of default.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Notice to the Commissioner of default. 207.256 Section 207.256 Housing and Urban Development Regulations Relating to Housing and...

  15. 24 CFR 203.320 - Notice and date of termination by Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Notice and date of termination by Commissioner. 203.320 Section 203.320 Housing and Urban Development Regulations Relating to Housing and...

  16. 24 CFR 203.320 - Notice and date of termination by Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Notice and date of termination by Commissioner. 203.320 Section 203.320 Housing and Urban Development Regulations Relating to Housing and...

  17. 24 CFR 207.256 - Notice to the Commissioner of default.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Notice to the Commissioner of default. 207.256 Section 207.256 Housing and Urban Development Regulations Relating to Housing and...

  18. 24 CFR 203.320 - Notice and date of termination by Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Notice and date of termination by Commissioner. 203.320 Section 203.320 Housing and Urban Development Regulations Relating to Housing and...

  19. 77 FR 26537 - Notice of Commissioners and Staff Attendance at FERC Leadership Development Program Graduation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-04

    ... Energy Regulatory Commission Notice of Commissioners and Staff Attendance at FERC Leadership Development... Leadership Development Program Graduation/Induction Ceremony: 888 First Street NE., Washington, DC 20426. May... 2012 Leadership Development Program and graduate 15 employees from the 2011 program. Dated: April...

  20. Summary of Second Language Provisions in the New Part 100 of the Commissioner's Regulations.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany. Bureau of Foreign Languages Education.

    An overview of the foreign language requirements in the new Part 100 of the New York State Commissioner's regulations for public schools is presented to aid local school personnel in designing foreign language programs and advising students regarding the new statewide requirements. The summary first defines the terms used, and then outlines: the…

  1. 17 CFR 200.43 - Disposition of business by exercise of authority delegated to individual Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... exercise of authority delegated to individual Commissioner. 200.43 Section 200.43 Commodity and Securities... Disposition of Commission Business § 200.43 Disposition of business by exercise of authority delegated to... Commission; Provided, however, That no such delegation shall authorize the duty officer (i) to exercise...

  2. 21 CFR 170.15 - Adoption of regulation on initiative of Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Adoption of regulation on initiative of Commissioner. 170.15 Section 170.15 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD ADDITIVES General Provisions § 170.15 Adoption of regulation on initiative...

  3. 21 CFR 860.132 - Procedures when the Commissioner initiates a performance standard or premarket approval...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) MEDICAL DEVICES MEDICAL DEVICE CLASSIFICATION PROCEDURES Reclassification § 860.132 Procedures... the classification of a device based upon new information relevant to its classification when the Commissioner initiates a proceeding either to develop a performance standard for the device if in class II,...

  4. 21 CFR 860.132 - Procedures when the Commissioner initiates a performance standard or premarket approval...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Procedures when the Commissioner initiates a... Section 860.132 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES MEDICAL DEVICE CLASSIFICATION PROCEDURES Reclassification § 860.132...

  5. 19 CFR 191.1 - Authority of the Commissioner of Customs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Authority of the Commissioner of Customs. 191.1 Section 191.1 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Customs. Pursuant to Treasury Department Order No. 165, Revised (T.D. 53654, 19 FR 7241), as amended,...

  6. 19 CFR 115.18 - Decision of Commissioner of Customs final.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Decision of Commissioner of Customs final. 115.18 Section 115.18 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL...

  7. 43 CFR 422.4 - Responsibilities of the Commissioner of Reclamation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Responsibilities of the Commissioner of Reclamation. 422.4 Section 422.4 Public Lands: Interior Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR LAW ENFORCEMENT AUTHORITY AT BUREAU OF RECLAMATION...

  8. 17 CFR 200.43 - Disposition of business by exercise of authority delegated to individual Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... exercise of authority delegated to individual Commissioner. 200.43 Section 200.43 Commodity and Securities... Disposition of Commission Business § 200.43 Disposition of business by exercise of authority delegated to... Commission; Provided, however, That no such delegation shall authorize the duty officer (i) to exercise...

  9. TORONTO HARBOUR COMMISSIONERS (THC) SOIL RECYCLE TREATMENT TRAIN - APPLICATIONS ANALYSIS REPORT

    EPA Science Inventory

    The Toronto Harbour Commissioners (THC) have developed a soil treatment train designed to treat inorganic and organic contaminants in soils. THC has conducted a large-scale demonstration of these technologies in an attempt to establish that contaminated soils at the Toronto Port ...

  10. 75 FR 70932 - Office of the Commissioner of Food and Drugs; Delegation of Authority

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-19

    ... HUMAN SERVICES Food and Drug Administration Office of the Secretary Office of the Commissioner of Food... Food and Drugs the authorities vested in the Secretary of Health and Human Services under section 4 of... Smoking Prevention and Tobacco Control Act (Tobacco Control Act). These authorities may be...

  11. 76 FR 71966 - Notice of Commissioner and Staff Attendance at ReliabilityFirst

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Commissioner and Staff Attendance at ReliabilityFirst Corporation Meetings The Federal Energy Regulatory Commission hereby gives notice that members of the Commission and/or Commission staff may attend...

  12. SITE DEMONSTRATION BULLETIN: SOIL RECYCLING TREATMENT TRAIN - THE TORONTO HARBOUR COMMISSIONERS

    EPA Science Inventory

    The Toronto Harbour Commissioners (THC) have developed a soil treatment train designed to treat inorganic and organic contaminants in soils. THC has conducted a large-scale demonstration of these technologies in an attempt to establish that contaminated soils at the Toronto Port...

  13. 28 CFR 2.24 - Review of panel recommendation by the Regional Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Review of panel recommendation by the Regional Commissioner. 2.24 Section 2.24 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS, YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States...

  14. 28 CFR 2.24 - Review of panel recommendation by the Regional Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Review of panel recommendation by the Regional Commissioner. 2.24 Section 2.24 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS, YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States...

  15. 28 CFR 16.201 - Voting by the Commissioners without joint deliberation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Voting by the Commissioners without joint deliberation. 16.201 Section 16.201 Judicial Administration DEPARTMENT OF JUSTICE PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Public Observation of Parole Commission Meetings § 16.201 Voting by...

  16. 28 CFR 16.201 - Voting by the Commissioners without joint deliberation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Voting by the Commissioners without joint deliberation. 16.201 Section 16.201 Judicial Administration DEPARTMENT OF JUSTICE PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Public Observation of Parole Commission Meetings § 16.201 Voting by...

  17. 28 CFR 16.201 - Voting by the Commissioners without joint deliberation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Voting by the Commissioners without joint deliberation. 16.201 Section 16.201 Judicial Administration DEPARTMENT OF JUSTICE PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Public Observation of Parole Commission Meetings § 16.201 Voting by...

  18. 28 CFR 16.201 - Voting by the Commissioners without joint deliberation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Voting by the Commissioners without joint deliberation. 16.201 Section 16.201 Judicial Administration DEPARTMENT OF JUSTICE PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Public Observation of Parole Commission Meetings § 16.201 Voting by...

  19. 78 FR 42064 - Before Commissioners: Jon Wellinghoff, Chairman; Philip D. Moeller, John R. Norris, Cheryl A...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Before Commissioners: Jon Wellinghoff, Chairman; Philip D. Moeller, John R... and thresholds is an equally effective and efficient means of addressing the Commission's directive...

  20. 20 CFR 423.3 - Other process directed to the Social Security Administration or the Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Other process directed to the Social Security Administration or the Commissioner. 423.3 Section 423.3 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SERVICE OF PROCESS § 423.3 Other process directed to the Social Security Administration or...

  1. 20 CFR 423.3 - Other process directed to the Social Security Administration or the Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Other process directed to the Social Security Administration or the Commissioner. 423.3 Section 423.3 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SERVICE OF PROCESS § 423.3 Other process directed to the Social Security Administration or...

  2. 20 CFR 423.3 - Other process directed to the Social Security Administration or the Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Other process directed to the Social Security Administration or the Commissioner. 423.3 Section 423.3 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SERVICE OF PROCESS § 423.3 Other process directed to the Social Security Administration or...

  3. 20 CFR 423.3 - Other process directed to the Social Security Administration or the Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Other process directed to the Social Security Administration or the Commissioner. 423.3 Section 423.3 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SERVICE OF PROCESS § 423.3 Other process directed to the Social Security Administration or...

  4. 20 CFR 423.3 - Other process directed to the Social Security Administration or the Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Other process directed to the Social Security Administration or the Commissioner. 423.3 Section 423.3 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SERVICE OF PROCESS § 423.3 Other process directed to the Social Security Administration or...

  5. 28 CFR 2.24 - Review of panel recommendation by the Regional Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Review of panel recommendation by the Regional Commissioner. 2.24 Section 2.24 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS, YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States...

  6. 28 CFR 2.59 - Designation of a Commissioner to act as a hearing examiner.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Designation of a Commissioner to act as a hearing examiner. 2.59 Section 2.59 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS, YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States...

  7. 76 FR 13111 - Compassionate Allowances for Autoimmune Disease, Office of the Commissioner; Hearing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ...-mail addressed to Compassionate.Allowances@ssa.gov ; or Mail to Jamillah Jackson, Deputy Director... Jamillah Jackson, Deputy Director, Office of Compassionate Allowances and Disability Outreach, ODP, ORDP..., Supplemental Security Income.) Dated: March 3, 2011. Michael J. Astrue, Commissioner of Social...

  8. Cortical Reorganization following Injury Early in Life

    PubMed Central

    Artzi, Moran; Shiran, Shelly Irene; Weinstein, Maya; Myers, Vicki; Tarrasch, Ricardo; Schertz, Mitchell; Fattal-Valevski, Aviva; Miller, Elka; Gordon, Andrew M.; Green, Dido; Ben Bashat, Dafna

    2016-01-01

    The brain has a remarkable capacity for reorganization following injury, especially during the first years of life. Knowledge of structural reorganization and its consequences following perinatal injury is sparse. Here we studied changes in brain tissue volume, morphology, perfusion, and integrity in children with hemiplegia compared to typically developing children, using MRI. Children with hemiplegia demonstrated reduced total cerebral volume, with increased cerebrospinal fluid (CSF) and reduced total white matter volumes, with no differences in total gray matter volume, compared to typically developing children. An increase in cortical thickness at the hemisphere contralateral to the lesion (CLH) was detected in motor and language areas, which may reflect compensation for the gray matter loss in the lesion area or retention of ipsilateral pathways. In addition, reduced cortical thickness, perfusion, and surface area were detected in limbic areas. Increased CSF volume and precentral cortical thickness and reduced white matter volume were correlated with worse motor performance. Brain reorganization of the gray matter within the CLH, while not necessarily indicating better outcome, is suggested as a response to neuronal deficits following injury early in life. PMID:27298741

  9. Dynamic reorganization of the actin cytoskeleton

    PubMed Central

    Gressin, Laurène; Théry, Manuel; Blanchoin, Laurent

    2015-01-01

    Cellular processes, including morphogenesis, polarization, and motility, rely on a variety of actin-based structures. Although the biochemical composition and filament organization of these structures are different, they often emerge from a common origin. This is possible because the actin structures are highly dynamic. Indeed, they assemble, grow, and disassemble in a time scale of a second to a minute. Therefore, the reorganization of a given actin structure can promote the formation of another. Here, we discuss such transitions and illustrate them with computer simulations. PMID:26989473

  10. Evidence of cortical reorganization in hemiparetic patients

    SciTech Connect

    Brion, J.P.; Demeurisse, G.; Capon, A. )

    1989-08-01

    We studied the mechanisms underlying the recovery of motor function of the hand using a bidimensional xenon-133 inhalation technique to measure regional cerebral blood flow at rest and during the performance of a motor task (test condition). The regional cerebral blood flow patterns under rest and test conditions were compared in normal control and in stroke patients with either a cortico-subcortical or a deep-seated lesion. Functional recovery appears to depend upon cortical reorganization involving both hemispheres, particularly in both parietal regions in the subgroup of patients with cortico-subcortical lesions.

  11. 76 FR 71878 - Corporate Reorganizations; Allocation of Basis in “All Cash D” Reorganizations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-21

    ... ``All Cash D'' Reorganizations AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Final and... the issuing corporation. For example, assume that J owns all the stock of corporations X and Y, and X owns all of the stock of corporation T. X has a $150 basis in the T stock. The corporations do not...

  12. Compressing bitmap indices by data reorganization

    SciTech Connect

    Pinar, Ali; Tao, Tao; Ferhatosmanoglu, Hakan

    2004-07-01

    Many scientific applications generate massive volumes of data through observations or computer simulations, bringing up the need for effective indexing methods for efficient storage and retrieval of scientific data. Unlike conventional databases, scientific data is mostly read-only and its volume can reach to the order of petabytes, making a compact index structure vital. Bit map indexing has been successfully applied to scientific databases by exploiting the fact that scientific data are enumerated or numerical. Bitmap indices can be compressed with variants of run length encoding for a compact index structure. However even this may not be enough for the enormous data generated in some applications such as high energy physics. In this paper, we study how to reorganize bitmap tables for improved compression rates. Our algorithms are used just as a preprocessing step, thus there is no need to revise the current indexing techniques and the query processing algorithms. We introduce the tuple reordering problem, which aims to reorganize database tuples for optimal compression rates. We propose Gray code ordering algorithm for this NP-Complete problem, which is an in-place algorithm, and runs in linear time in the order of the size of the database. We also discuss how the tuple reordering problem can be reduced to the traveling salesperson problem. Our experimental results on real data sets show that the compression ratio can be improved by a factor of 4 to 7.

  13. Survey of state insurance commissioners concerning genetic testing and life insurance

    SciTech Connect

    McEwen, J.E.; McCarty, K.; Reilly, P.R. )

    1992-10-01

    Rapid advances in genetic testing have stimulated growing concern about the potential for misuse of genetic data by insurance companies, employers, and other third parties. Thus far, reports of genetically based discrimination in life insurance have been anecdotal. Reasoning that state insurance commissioners were likely to be aware of (1) the extent of current use of and interest in genetic tests by life insurers and (2) consumer complaints about insurance being denied because of genetic condition or because of genetic test results, the authors conducted a survey of that group. They received responses from 42 of the 51 jurisdictions. Results suggest (1) that those who regulate the life insurance industry do not yet perceive genetic testing to pose a significant problem in how insurers rate applicants, (2) that life insurers have much legal latitude to require genetic tests, and (3) that so far few consumers have formally complained to commissioners about the use of genetic data by life insurers.

  14. [Tasks and experiences of the Federal Government Commissioner for Patients' Affairs].

    PubMed

    Kühn-Mengel, H

    2009-01-01

    On the basis of Section 140h of Social Code Book V (German abbreviation: SGB V), which had been newly included in 2004, the Federal Government Commissioner for Patients' Affairs speaks out in favor of a meticulous implementation of patients' right to education, information and joint decision-making in all spheres of the health care system, whenever the commissioner attends the respective panels or events, and also in public. Currently, the commissioner is member of a parliamentary working group which is charged with the elaboration of the contents of a law relating to patients' rights, and experts and patients' organizations are involved in this procedure as well. For this purpose, but also with regard to other key panels of the health care system, self-help organizations are important partners for collaboration, due to their commitment, their experiences and the inspirations they provide. Therefore, they have been strengthened in essential aspects by the policy of the Federal Government over the past few years.

  15. 76 FR 26603 - Reorganization of Sector North Carolina; Technical Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ... Macon, NC, with a Marine Safety Unit (MSU) in Wilmington, NC, responsible for the Cape Fear River Marine... the Cape Fear River Marine Inspection and COTP Zones. The Coast Guard has now reorganized Sector North... Fear River Marine Inspection and COTP Zones. This reorganization is intended to improve...

  16. Subcortical functional reorganization due to early blindness.

    PubMed

    Coullon, Gaelle S L; Jiang, Fang; Fine, Ione; Watkins, Kate E; Bridge, Holly

    2015-04-01

    Lack of visual input early in life results in occipital cortical responses to auditory and tactile stimuli. However, it remains unclear whether cross-modal plasticity also occurs in subcortical pathways. With the use of functional magnetic resonance imaging, auditory responses were compared across individuals with congenital anophthalmia (absence of eyes), those with early onset (in the first few years of life) blindness, and normally sighted individuals. We find that the superior colliculus, a "visual" subcortical structure, is recruited by the auditory system in congenital and early onset blindness. Additionally, auditory subcortical responses to monaural stimuli were altered as a result of blindness. Specifically, responses in the auditory thalamus were equally strong to contralateral and ipsilateral stimulation in both groups of blind subjects, whereas sighted controls showed stronger responses to contralateral stimulation. These findings suggest that early blindness results in substantial reorganization of subcortical auditory responses.

  17. Reorganization of School Units. Bulletin, 1935, No. 15

    ERIC Educational Resources Information Center

    Cook, Katherine M., Comp.

    1936-01-01

    This bulletin reports the findings of a conference of school officials called by the U.S. Commissioner of Education, Dr. J. W. Studebaker, in the Office of Education, June 17, 18, and 19, 1935. Attending this conference, and contributing to the sections of this bulletin were: Howard A. Dawson, J. Cayce Morrison, Edgar L. Morphet, D. H. Sutton,…

  18. Postural reorganization induced by torso cutaneous covibration.

    PubMed

    Lee, Beom-Chan; Martin, Bernard J; Ho, Allison; Sienko, Kathleen H

    2013-05-01

    Cutaneous information from joints has been attributed proprioceptive properties similar to those of muscle spindles. This study aimed to assess whether vibration-induced changes in torso cutaneous information contribute to whole-body postural reorganization in humans. Ten healthy young adults stood in normal and Romberg stances with six vibrating actuators positioned on the torso in contact with the skin over the left and right external oblique, internal oblique, and erector spinae muscle locations at the L4/L5 vertebrae level. Vibrations around the torso were randomly applied at two locations simultaneously (covibration) or at all locations simultaneously. Kinematic analysis of the body segments indicated that covibration applied to the skin over the internal oblique muscles induced shifts of both the head and torso in the anterior direction (torso flexion) while the hips shifted in the posterior direction (ankle plantar flexion). Conversely, covibration applied to the skin over the erector spinae muscle locations produced opposite effects. However, covibration applied to the skin over the left internal oblique and left erector spinae, the right internal oblique and right erector spinae, or at all locations simultaneously did not induce any significant postural changes. In addition, the center of pressure position as measured by the force plate was unaffected by all covibration conditions tested. These results were independent of stance and suggest an integrated and coordinated reorganization of posture in response to vibration-induced changes in cutaneous information. In addition, combinations of vibrotactile stimuli over multiple locations exhibit directional summation properties in contrast to the individual responses we observed in our previous work.

  19. Language organization and reorganization in epilepsy

    PubMed Central

    Hamberger, Marla J.; Cole, Jeffrey

    2011-01-01

    The vast majority of healthy individuals are left hemisphere dominant for language; however, individuals with left hemisphere epilepsy have a higher likelihood of atypical language organization. The cerebral organization of language in epilepsy has been studied with invasive procedures such as Wada testing and electrical cortical stimulation mapping (ESM), and more recently, with noninvasive neuroimaging techniques such as functional magnetic resonance imaging (fMRI). Investigators have used these techniques to explore the influence of unique clinical features inherent in epilepsy that might contribute to the reorganization of language, such as location of seizure onset, age of seizure onset, and extent of interictal epileptiform activity. In this paper, we review the contribution of these and other clinical variables to the lateralization and localization of language in epilepsy, and how these patient-related variables affect the results from these three different, yet complementary methodologies. Unlike the abrupt language changes that occur following acute brain injury with disruption of established language circuits, converging evidence suggests that the chronic nature of epileptic activity can result in a developmental shift of language from the left to the right hemisphere or re-routing of language pathways from traditional to non-traditional areas within the dominant left hemisphere. Clinical variables have been shown to contribute to cerebral language reorganization in the setting of chronic seizure disorders, yet such factors have not been reliable predictors of altered language networks in individual patients, underscoring the need for language lateralization and localization procedures when definitive identification of language cortex is necessary for clinical care. PMID:21842185

  20. School Library Policy Statement.

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education, Winnipeg. Instructional Resources Branch.

    The School Library Policy Statement for Manitoba schools begins with the mission statement of Manitoba Education and Training and the Goals of Learning for Manitoba. Statements of Manitoba's School Library Policy and the Philosophy of the School Library Program are also provided, together with an outline of the responsibilities of both Manitoba's…

  1. Substance Abuse. Policy Statement.

    ERIC Educational Resources Information Center

    National Collaboration for Youth, Washington, DC.

    This paper presents the policy statement on substance abuse from the National Collaboration for Youth (NCY). The policy statement section lists programs and activities supported by the NCY. A section on background includes a statement of the issue of substance abuse. Areas examined in this section include alcohol abuse and drunk driving among…

  2. Technology evaluation report: Toronto Harbour Commissioners (THC) soil recycle treatment train

    SciTech Connect

    Ehrenreich, L.C.; Matuson, A.; Peters, J.; Evans, J.

    1993-07-01

    The report summarizes the results and activities of the demonstration testing of Toronto Harbor Commissioners (THC) Soil Recycle Treatment Train. The Demonstration was conducted at a site within the Port Industrial District (PID) in Toronto, Ontario, Canada under the Superfund Innovative Technology Evaluation (SITE) Program developed by the US Environmental Protection Agency (EPA). The demonstration examined a part of THC's on-going evaluation of the treatment train during the first nine months of 1992. EPA elected to sample the process during the processing of Soil B, which based on field sampling, was expected to exhibit relatively high organic (oil and grease, s) and inorganic (heavy metals) contaminants.

  3. The role of ocean-atmosphere reorganizations in glacial cycles

    NASA Astrophysics Data System (ADS)

    Broecker, Wallace S.; Denton, George H.

    A case is made that glacial-to-interglacial transitions involve major reorganizations of the ocean-atmosphere system. Such reorganizations constitute jumps between stable modes of operation which cause changes in the greenhouse gas content and albedo of the atmosphere. Only in this way can the rapidity of glacial terminations, the hemispheric synchroneity and symmetry of mountain glaciation, and the large polar air temperature and dustiness variations be accounted for. If these reorganizations are driven in some fashion by orbitally induced seasonal insolation changes, then the connection between insolation and climate is most likely through impacts of fresh water transport on the ocean's salinity distribution.

  4. The role of ocean-atmosphere reorganizations is glacial cycles

    NASA Astrophysics Data System (ADS)

    Broecker, Wallace S.; Denton, George H.

    1989-10-01

    A case is made that glacial-to-interglacial transitions involve major reorganizations of the ocean-atmosphere system. Such reorganizations constitute jumps between stable modes of operation which cause changes in the greenhouse gas content and albedo of the atmosphere. Only in this way can the rapidity of glacial terminations, the hemispheric synchroneity and symmetry of mountain glaciation, and the large polar air temperature and dustiness variations be accounted for. If these reorganizations are driven in some fashion by orbitally induced seasonal insolation changes, then the connection between insolation and climate is most likely through impacts of fresh water transport on the ocean's salinity distribution.

  5. Reorganization of the human central nervous system.

    PubMed

    Schalow, G; Zäch, G A

    2000-10-01

    The key strategies on which the discovery of the functional organization of the central nervous system (CNS) under physiologic and pathophysiologic conditions have been based included (1) our measurements of phase and frequency coordination between the firings of alpha- and gamma-motoneurons and secondary muscle spindle afferents in the human spinal cord, (2) knowledge on CNS reorganization derived upon the improvement of the functions of the lesioned CNS in our patients in the short-term memory and the long-term memory (reorganization), and (3) the dynamic pattern approach for re-learning rhythmic coordinated behavior. The theory of self-organization and pattern formation in nonequilibrium systems is explicitly related to our measurements of the natural firing patterns of sets of identified single neurons in the human spinal premotor network and re-learned coordinated movements following spinal cord and brain lesions. Therapy induced cell proliferation, and maybe, neurogenesis seem to contribute to the host of structural changes during the process of re-learning of the lesioned CNS. So far, coordinated functions like movements could substantially be improved in every of the more than 100 patients with a CNS lesion by applying coordination dynamic therapy. As suggested by the data of our patients on re-learning, the human CNS seems to have a second integrative strategy for learning, re-learning, storing and recalling, which makes an essential contribution of the functional plasticity following a CNS lesion. A method has been developed by us for the simultaneous recording with wire electrodes of extracellular action potentials from single human afferent and efferent nerve fibres of undamaged sacral nerve roots. A classification scheme of the nerve fibres in the human peripheral nervous system (PNS) could be set up in which the individual classes of nerve fibres are characterized by group conduction velocities and group nerve fibre diameters. Natural impulse patterns

  6. Compensatory neural reorganization in Tourette syndrome.

    PubMed

    Jackson, Stephen R; Parkinson, Amy; Jung, Jeyoung; Ryan, Suzanne E; Morgan, Paul S; Hollis, Chris; Jackson, Georgina M

    2011-04-12

    Children with neurological disorders may follow unique developmental trajectories whereby they undergo compensatory neuroplastic changes in brain structure and function that help them gain control over their symptoms. We used behavioral and brain imaging techniques to investigate this conjecture in children with Tourette syndrome (TS). Using a behavioral task that induces high levels of intermanual conflict, we show that individuals with TS exhibit enhanced control of motor output. Then, using structural (diffusion-weighted imaging) brain imaging techniques, we demonstrate widespread differences in the white matter (WM) microstructure of the TS brain that include alterations in the corpus callosum and forceps minor (FM) WM that significantly predict tic severity in TS. Most importantly, we show that task performance for the TS group (but not for controls) is strongly predicted by the WM microstructure of the FM pathways that lead to the prefrontal cortex and by the functional magnetic resonance imaging blood oxygen level-dependent response in prefrontal areas connected by these tracts. These results provide evidence for compensatory brain reorganization that may underlie the increased self-regulation mechanisms that have been hypothesized to bring about the control of tics during adolescence.

  7. Adult plasticity and cortical reorganization after peripheral lesions.

    PubMed

    Sammons, Rosanna P; Keck, Tara

    2015-12-01

    Following loss of input due to peripheral lesions, functional reorganization occurs in the deprived cortical region in adults. Over a period of hours to months, cells in the lesion projection zone (LPZ) begin to respond to novel stimuli. This reorganization is mediated by two processes: a reduction of inhibition in a gradient throughout the cortex and input remapping via sprouting of axonal arbors from cortical regions spatially adjacent to the LPZ, and strengthening of pre-existing subthreshold inputs. Together these inputs facilitate receptive field remapping of cells in the LPZ. Recent experiments have revealed time courses and potential interactions of the mechanisms associated with functional reorganization, suggesting that large scale reorganization in the adult may utilize plasticity mechanisms prominent during development.

  8. Administrative Control in Academic Departments and Response to Reorganization

    ERIC Educational Resources Information Center

    Ryan, Doris W.

    1970-01-01

    Studies the response of 15 academic departments at Ohio State University to reorganization. Implications of the study deal with methods of introducing change, the importance of group norms, and the link between informal norms and existing formal structure. (MK)

  9. Reorganization of the Yearbook Staffs for the 1980s.

    ERIC Educational Resources Information Center

    Vossen, Daniel L.

    1981-01-01

    A diagram of the reorganized yearbook staff, reflective of current emphasis on magazine-style layout designs, and adaptable for colleges, high schools, mid-high schools, and junior high schools. Listings of responsibilities for each integral staff member. (RL)

  10. Toronto Harbour Commissioners (THC) soil recycle treatment train. Applications analysis report

    SciTech Connect

    Ehrenreich, L.C.; Matuson, A.; Peters, J.; Evans, J.

    1993-04-01

    This project consists of a demonstration of the Toronto Harbour Commissioners (THC) Soil Recycle Treatment Train. The treatment train consists of three processes. The first process utilizes an attrition soil wash process to separate relatively uncontaminated soil from a more heavily contaminated fine slurry. The contaminated fine slurry is then further processed in a metals removal process or a bioslurry reactor process or both to remove organic contaminants and heavy metals contamination. The Toronto Harbour Commissioners conducted a long-term evaluation of this treatment train at a 55 tons per day pilot plant at 185 Cherry Street in the port of Toronto, located in Toronto, Ontario, Canada. The Superfund Innovative Technology Evaluation (SITE) Program conducted a demonstration project that examined in detail the processing of soil from one of the sites being evaluated in the overall project. The goals of this study were to evaluate the technical effectiveness and economics of a treatment process sequence and to assess the potential applicability of the process to other wastes and/or other Superfund and hazardous waste sites.

  11. Cortical reorganization after spinal cord injury: always for good?

    PubMed Central

    Moxon, Karen A.; Oliviero, Antonio; Aguilar, Juan; Foffani, Guglielmo

    2015-01-01

    Plasticity constitutes the basis of behavioral changes as a result of experience. It refers to neural network shaping and re-shaping at the global level and to synaptic contacts remodeling at the local level, either during learning or memory encoding, or as a result of acute or chronic pathological conditions. ‘Plastic’ brain reorganization after central nervous system lesions has a pivotal role in the recovery and rehabilitation of sensory and motor dysfunction, but can also be “maladaptive”. Moreover, it is clear that brain reorganization it is not a “static” phenomenon but rather a very dynamic process. Spinal cord injury immediately initiates a change in brain state and starts cortical reorganization. In the long term, the impact of injury – with or without accompanying therapy – on the brain is a complex balance between supraspinal reorganization and spinal recovery. The degree of cortical reorganization after spinal cord injury is highly variable, and can range from no reorganization (i.e. “silencing”) to massive cortical remapping. This variability critically depends on the species, the age of the animal when the injury occurs, the time after the injury has occurred, and the behavioral activity and possible therapy regimes after the injury. We will briefly discuss these dependencies, trying to highlight their translational value. Overall, it is not only necessary to better understand how the brain can reorganize after injury with or without therapy, it is also necessary to clarify when and why brain reorganization can be either “good” or “bad” in terms of its clinical consequences. This information is critical in order to develop and optimize cost-effective therapies to maximize functional recovery while minimizing maladaptive states after spinal cord injury. PMID:24997269

  12. 75 FR 60767 - Office of the Commissioner; Request for Comments on the Food and Drug Administration Fiscal Year...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-01

    ... HUMAN SERVICES Food and Drug Administration Office of the Commissioner; Request for Comments on the Food... Global Supply Chain, (3) Strengthen Compliance and Enforcement Activities to Support Public Health, and... AGENCY: Food and Drug Administration, HHS. ACTION: Notice; request for comments. SUMMARY: The Food...

  13. Index to the Reports of the Commissioner of Education: 1867-1907. Bulletin, 1909, No. 7. Whole Number 407

    ERIC Educational Resources Information Center

    United States Bureau of Education, Department of the Interior, 1909

    1909-01-01

    What is presented in this bulletin is the first essay in the history of the Bureau of Education toward a comprehensive index of the annual reports of the Commissioner. It includes authors and subjects with an analysis of the more important articles, for the years 1876 to 1907, inclusive. [Best copy available has been provided.

  14. 75 FR 42747 - Smart Grid Update; Notice of Commissioner and Staff Attendance at FERC/NARUC Collaborative on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ... Energy Regulatory Commission Smart Grid Update; Notice of Commissioner and Staff Attendance at FERC/NARUC Collaborative on Smart Response Meeting July 15, 2010. The Federal Energy Regulatory Commission hereby gives.../NARUC Collaborative on Smart Response: Sacramento Convention Center, 1400 J Street, Sacramento, CA...

  15. 20 CFR 403.140 - If the Commissioner authorizes testimony, what will be the scope and form of that testimony?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., what will be the scope and form of that testimony? 403.140 Section 403.140 Employees' Benefits SOCIAL... PROCEEDINGS § 403.140 If the Commissioner authorizes testimony, what will be the scope and form of that testimony? The employee's testimony must be limited to matters that were specifically approved. We...

  16. The Canadian Human Rights Commission and Issues of Concern for Aboriginal Women. Notes for Remarks, by the Deputy Chief Commissioner.

    ERIC Educational Resources Information Center

    Falardeau-Ramsay, Michelle

    This speech by the deputy chief commissioner of the Canadian Human Rights Commission discusses human rights, employment security, and pay-equity issues for Native Canadian women. The speech, offered in both English and French, calls the inequality of opportunity for Native Canadians a "national tragedy." It describes efforts to bring…

  17. 43 CFR 417.5 - Duties of the Commissioner of Indian Affairs with respect to Indian reservations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... IMPLEMENTING COLORADO RIVER WATER CONSERVATION MEASURES WITH LOWER BASIN CONTRACTORS AND OTHERS § 417.5 Duties... diversion, delivery, distribution and use of Colorado River water, the Commissioner shall, within the limits... each reservation, the amount and rate of return flows to the river, municipal water requirements,...

  18. 43 CFR 417.5 - Duties of the Commissioner of Indian Affairs with respect to Indian reservations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... IMPLEMENTING COLORADO RIVER WATER CONSERVATION MEASURES WITH LOWER BASIN CONTRACTORS AND OTHERS § 417.5 Duties... diversion, delivery, distribution and use of Colorado River water, the Commissioner shall, within the limits... each reservation, the amount and rate of return flows to the river, municipal water requirements,...

  19. 43 CFR 417.5 - Duties of the Commissioner of Indian Affairs with respect to Indian reservations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... IMPLEMENTING COLORADO RIVER WATER CONSERVATION MEASURES WITH LOWER BASIN CONTRACTORS AND OTHERS § 417.5 Duties... diversion, delivery, distribution and use of Colorado River water, the Commissioner shall, within the limits... each reservation, the amount and rate of return flows to the river, municipal water requirements,...

  20. 43 CFR 417.5 - Duties of the Commissioner of Indian Affairs with respect to Indian reservations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... IMPLEMENTING COLORADO RIVER WATER CONSERVATION MEASURES WITH LOWER BASIN CONTRACTORS AND OTHERS § 417.5 Duties... diversion, delivery, distribution and use of Colorado River water, the Commissioner shall, within the limits... each reservation, the amount and rate of return flows to the river, municipal water requirements,...

  1. 43 CFR 417.5 - Duties of the Commissioner of Indian Affairs with respect to Indian reservations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... IMPLEMENTING COLORADO RIVER WATER CONSERVATION MEASURES WITH LOWER BASIN CONTRACTORS AND OTHERS § 417.5 Duties... diversion, delivery, distribution and use of Colorado River water, the Commissioner shall, within the limits... each reservation, the amount and rate of return flows to the river, municipal water requirements,...

  2. 77 FR 1483 - Commissioners of Public Works of the City of Spartanburg, SC; Notice of Availability of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Commissioners of Public Works of the City of Spartanburg, SC; Notice of... Commission in the Public Reference Room or may be viewed on the Commission's Web site at...

  3. 20 CFR 408.1060 - What happens if a Federal Court remands your case to the Commissioner?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What happens if a Federal Court remands your case to the Commissioner? 408.1060 Section 408.1060 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Determinations and the Administrative Review...

  4. 45 CFR 1321.21 - Submission of the State plan or plan amendment to the Commissioner for approval.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Submission of the State plan or plan amendment to the Commissioner for approval. 1321.21 Section 1321.21 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  5. 45 CFR 1321.21 - Submission of the State plan or plan amendment to the Commissioner for approval.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Submission of the State plan or plan amendment to the Commissioner for approval. 1321.21 Section 1321.21 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  6. 45 CFR 1321.21 - Submission of the State plan or plan amendment to the Commissioner for approval.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Submission of the State plan or plan amendment to the Commissioner for approval. 1321.21 Section 1321.21 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  7. 45 CFR 1321.21 - Submission of the State plan or plan amendment to the Commissioner for approval.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Submission of the State plan or plan amendment to the Commissioner for approval. 1321.21 Section 1321.21 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  8. 45 CFR 1321.21 - Submission of the State plan or plan amendment to the Commissioner for approval.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Submission of the State plan or plan amendment to the Commissioner for approval. 1321.21 Section 1321.21 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  9. Rotational reorganization of doped cholesteric liquid crystalline films.

    PubMed

    Eelkema, Rienk; Pollard, Michael M; Katsonis, Nathalie; Vicario, Javier; Broer, Dirk J; Feringa, Ben L

    2006-11-08

    In this paper an unprecedented rotational reorganization of cholesteric liquid crystalline films is described. This rotational reorganization results from the conversion of a chiral molecular motor dopant to an isomer with a different helical twisting power, leading to a change in the cholesteric pitch. The direction of this reorganization is correlated to the sign of the change in helical twisting power of the dopant. The rotational reorganization of the liquid crystalline film was used to rotate microscopic objects 4 orders of magnitude larger than the bistable dopants in the film, which shows that molecular motors and switches can perform work. The surface of the doped cholesteric liquid crystalline films was found to possess a regular surface relief, whose periodicity coincides with typical cholesteric polygonal line textures. These surface features originate from the cholesteric superstructure in the liquid crystalline film, which in turn is the result of the presence of the chiral dopant. As such, the presence of the dopant is expressed in these distinct surface structures. A possible mechanism at the origin of the rotational reorganization of liquid crystalline films and the cholesteric surface relief is discussed.

  10. Excitation and inhibition jointly regulate cortical reorganization in adult rats.

    PubMed

    Benali, Alia; Weiler, Elke; Benali, Youssef; Dinse, Hubert R; Eysel, Ulf T

    2008-11-19

    The primary somatosensory cortex (SI) retains its capability for cortical reorganization after injury or differential use into adulthood. The plastic response of SI cells to peripheral stimulation is characterized by extension of cortical representations accompanied by changes of the receptive field size of neurons. We used intracortical microstimulation that is known to enforce local, intracortical synchronous activity, to induce cortical reorganization and applied immunohistochemical methods in the same individual animals to investigate how plasticity in the cortical topographic maps is linked to changes in the spatial layout of the inhibitory and excitatory neurotransmitter systems. The results reveal a differential spatiotemporal pattern of upregulation and downregulation of specific factors for an excitatory (glutamatergic) and an inhibitory (GABAergic) system, associated with changes of receptive field size and reorganization of the somatotopic map in the rat SI. Predominantly local mechanisms are the specific reduction of the calcium-binding protein parvalbumin in inhibitory neurons and the low expression of the activity marker c-Fos. Reorganization in the hindpaw representation and in the adjacent SI cortical areas (motor cortex and parietal cortex) is accompanied by a major increase of the excitatory transmitter glutamate and c-Fos. The spatial extent of the reorganization appears to be limited by an increase of glutamic acid decarboxylase and the inhibitory transmitter GABA. The local and medium-range net effects are excitatory and can facilitate receptive field enlargements and cortical map expansion. The longer-range increase of inhibition appears suited to limit these effects and to prevent neurons from pathological hyperexcitability.

  11. 75 FR 8190 - Art Advisory Panel of the Commissioner of Internal Revenue Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... Art Advisory Panel. SUMMARY: It is in the public interest to continue the existence of the Art.... Statement of Public Interest. It is in the public interest to continue the existence of the Art...

  12. 77 FR 13389 - Art Advisory Panel of the Commissioner of Internal Revenue

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-06

    ... Panel. SUMMARY: It is in the public interest to continue the existence of the Art Advisory Panel. The.... Statement of Public Interest. It is in the public interest to continue the existence of the Art...

  13. Time to reorganize federal Earth system science and technology?

    NASA Astrophysics Data System (ADS)

    Kisslinger, Carl

    My usual reaction to plans to reorganize activities in the federal government is that these are the last resort of a bureaucrat who is faced with a tough problem and has no idea how to solve it. However, this may be the time to consider seriously a reorganization that would assemble key elements of Earth-oriented science and technology into a single federal agency. This is not a new idea, as proposals to achieve this goal have been formulated in the past and wiring diagrams for a new agency have been developed. These proposals have faded away in the face of resistance to substantial structural change that characterizes the federal bureaucracy.

  14. Aljoya Consensus Statement

    EPA Pesticide Factsheets

    A consensus statement of 100 experts meeting at the Aljoya Conference Center in Seattle, Washington in July 2000 for the First International Conference on Trans-Pacific Transport of Atmospheric Contaminants.

  15. Statement on Human Cloning

    MedlinePlus

    ... form Search American Association for the Advancement of Science Statement on Human Cloning Tweet The American Association for the Advancement of Science (AAAS) recognizes the intense debates within our society ...

  16. Audio-Visual Space Reorganization Study. RDU-75-05.

    ERIC Educational Resources Information Center

    Baker, Martha

    Space layout and work flow patterns in the Audiovisual Center at Purdue University were studied with respect to effective space utilization and the need for planning space requirements in relationship to the activities being performed. Space and work areas were reorganized to facilitate the flow of work and materials between areas, and equipment…

  17. Reorganizing U.S. Domestic Intelligence: Assessing the Options

    DTIC Science & Technology

    2008-01-01

    Terrorism and Deterrence,” Survival, Vol. 46, No. 4, November 2004, pp. 179–185. Sunstein , Cass R., “Terrorism and Probability Neglect,” Journal of Risk and...aspects of these attributes, see Fischoff et al. (2003), Huddy (2005), Davis and Silver (2004), and Sunstein (2003). 12 Reorganizing U.S

  18. Chinese and English Infants' Tone Perception: Evidence for Perceptual Reorganization

    ERIC Educational Resources Information Center

    Mattock, Karen; Burnham, Denis

    2006-01-01

    Over half the world's population speaks a tone language, yet infant speech perception research has typically focused on consonants and vowels. Very young infants can discriminate a wide range of native and nonnative consonants and vowels, and then in a process of "perceptual reorganization" over the 1st year, discrimination of most…

  19. Rural School District Reorganization on the Great Plains.

    ERIC Educational Resources Information Center

    Bryant, Miles

    2002-01-01

    Rural school district reorganization and school consolidation are put into perspective by reviewing the large population increases that fueled small-school growth in the Great Plains, 1870-1930. Since the Dust Bowl and Great Depression, population losses, improvements in transportation, and arguments advocating economies of scale and increased…

  20. 12 CFR 5.32 - Expedited procedures for certain reorganizations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Expedited procedures for certain reorganizations. 5.32 Section 5.32 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RULES, POLICIES, AND PROCEDURES FOR CORPORATE ACTIVITIES Expansion of Activities § 5.32 Expedited procedures...

  1. 12 CFR 5.32 - Expedited procedures for certain reorganizations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Expedited procedures for certain reorganizations. 5.32 Section 5.32 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RULES, POLICIES, AND PROCEDURES FOR CORPORATE ACTIVITIES Expansion of Activities § 5.32 Expedited procedures...

  2. 12 CFR 5.32 - Expedited procedures for certain reorganizations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Expedited procedures for certain reorganizations. 5.32 Section 5.32 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RULES, POLICIES, AND PROCEDURES FOR CORPORATE ACTIVITIES Expansion of Activities § 5.32 Expedited procedures...

  3. 12 CFR 5.32 - Expedited procedures for certain reorganizations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Expedited procedures for certain reorganizations. 5.32 Section 5.32 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RULES, POLICIES, AND PROCEDURES FOR CORPORATE ACTIVITIES Expansion of Activities § 5.32 Expedited procedures...

  4. 12 CFR 5.32 - Expedited procedures for certain reorganizations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Expedited procedures for certain reorganizations. 5.32 Section 5.32 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RULES, POLICIES, AND PROCEDURES FOR CORPORATE ACTIVITIES Expansion of Activities § 5.32 Expedited procedures...

  5. REORGANIZED SCIENCE CURRICULUM, 4A, FOURTH GRADE SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE FIFTH IN A SERIES OF 17 VOLUMES, THIS VOLUME PROVIDES THE FOURTH GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. THERE IS A DETAILED OUTLINE OF THE CONTENT FOR GRADE 4 FOR EACH OF THE FOLLOWING MAJOR AREAS AROUND WHICH…

  6. REORGANIZED SCIENCE CURRICULUM, 6A, SIXTH GRADE SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE NINTH IN A SERIES OF 17 VOLUMES, THIS VOLUME PROVIDES THE SIXTH GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. THE SIXTH GRADE SUPPLEMENT IS IN THREE VOLUMES. VOLUME 6A HAS A DETAILED OUTLINE OF THE SUBJECT MATTER FOR…

  7. REORGANIZED SCIENCE CURRICULUM, 7A, GRADE SEVEN SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE TWELFTH IN A SERIES OF 17 VOLUMES, THIS VOLUME PROVIDES THE SEVENTH GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. THE SEVENTH GRADE SUPPLEMENT IS IN TWO VOLUMES. VOLUME 7A CONTAINS INTRODUCTORY MATERIAL, A BRIEF…

  8. REORGANIZED SCIENCE CURRICULUM, 5A, FIFTH GRADE SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE SEVENTH IN A SERIES OF 17 VOLUMES, THIS VOLUME PROVIDES THE FIFTH GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. THERE IS A DETAILED OUTLINE OF SUBJECT MATTER FOR GRADE 5 FOR EACH OF THE FOLLOWING MAJOR AREAS AROUND…

  9. Solvent reorganization of electron transitions in viscous solvents

    SciTech Connect

    Ghorai, Pradip K.; Matyushov, Dmitry V.

    2006-04-14

    We develop a model of electron transfer reactions at conditions of nonergodicity when the time of solvent relaxation crosses the observation time window set up by the reaction rate. Solvent reorganization energy of intramolecular electron transfer in a charge-transfer molecule dissolved in water and acetonitrile is studied by molecular dynamics simulations at varying temperatures. We observe a sharp decrease of the reorganization energy at a temperature identified as the temperature of structural arrest due to cage effect, as discussed by the mode-coupling theory. This temperature also marks the onset of the enhancement of translational diffusion relative to rotational relaxation signaling the breakdown of the Stokes-Einstein relation. The change in the reorganization energy at the transition temperature reflects the dynamical arrest of the slow, collective relaxation of the solvent related to the relaxation of the solvent dipolar polarization. An analytical theory proposed to describe this effect agrees well with both the simulations and experimental Stokes shift data. The theory is applied to the analysis of charge-transfer kinetics in a low-temperature glass former. We show that the reorganization energy is substantially lower than its equilibrium value for the low-temperature portion of the data. The theory predicts the possibility of discontinuous changes in the dependence of the electron transfer rate on the free energy gap when the reaction switches between ergodic and nonergodic regimes.

  10. A Model for Reorganization Applying Quality Principles and Techniques.

    ERIC Educational Resources Information Center

    Brown, Lynne Branche; Stanley, Nancy Markle

    This paper chronicles ongoing alterations to the organizational structure of the acquisitions department at Pennsylvania State University using the tenets of total quality management (TQM). The movement toward reorganizing for process improvement began in late 1992 when the associate dean of libraries called the acquisitions department together to…

  11. East Texas Oilfield Schools: Expansion, Diminution and Reorganization

    ERIC Educational Resources Information Center

    LeCompte, Karon; Nicol, Tom

    2005-01-01

    This article describes the rise, diminution, and reorganization of East Texas Oilfield schools which was defined by the socio-economic conditions of the oil era, from the mid-nineteenth century until the third quarter of the twentieth century. Citizens of East Texas seized the opportunity at the time of oil discovery to provide superior school…

  12. Expediting Scientific Data Analysis with Reorganization of Data

    SciTech Connect

    Byna, Surendra; Wu, Kesheng

    2013-08-19

    Data producers typically optimize the layout of data files to minimize the write time. In most cases, data analysis tasks read these files in access patterns different from the write patterns causing poor read performance. In this paper, we introduce Scientific Data Services (SDS), a framework for bridging the performance gap between writing and reading scientific data. SDS reorganizes data to match the read patterns of analysis tasks and enables transparent data reads from the reorganized data. We implemented a HDF5 Virtual Object Layer (VOL) plugin to redirect the HDF5 dataset read calls to the reorganized data. To demonstrate the effectiveness of SDS, we applied two parallel data organization techniques: a sort-based organization on a plasma physics data and a transpose-based organization on mass spectrometry imaging data. We also extended the HDF5 data access API to allow selection of data based on their values through a query interface, called SDS Query. We evaluated the execution time in accessing various subsets of data through existing HDF5 Read API and SDS Query. We showed that reading the reorganized data using SDS is up to 55X faster than reading the original data.

  13. 76 FR 80331 - Foreign-Trade Zone 99-Wilmington, DE; Application for Reorganization and Expansion Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ... Zone 99--Wilmington, DE; Application for Reorganization and Expansion Under Alternative Site Framework... reorganize and expand the zone under the alternative site framework (ASF) adopted by the Board (74 FR 1170,...

  14. 20 CFR 410.691 - Referral to the Deputy Commissioner for Programs and Policy, or his or her designee, for hearing...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK..., Finality of Decisions, and Representation of Parties § 410.691 Referral to the Deputy Commissioner...

  15. RTI v medical ethics: some questions arising from the recent decision of the Chief Information Commissioner under the RTI Act.

    PubMed

    Nair, M R Hariharan

    2015-01-01

    Medical ethics attaches the utmost priority to the confidentiality of medical records. Hence, the decision of the Chief Information Commissioner (CIC) rendered on April 10, 2015 in Case No: CIC/KY/A/2014/001348SA Ms Jyoti Jeena v. PIO, Institute of Human Behaviour & Allied Science (hereinafter referred to as Jyoti Jeena), that the wife-applicant is entitled to get copies of the medical records of her estranged husband has raised many eyebrows.

  16. 29 CFR Appendix A to Part 24 - Your Rights Under the Energy Reorganization Act

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false Your Rights Under the Energy Reorganization Act A Appendix... ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Pt. 24, App. A Appendix A to Part 24—Your Rights Under the Energy Reorganization Act ER18JA11.003...

  17. 26 CFR 54.4980B-9 - Business reorganizations and employer withdrawals from multiemployer plans.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...-9 Business reorganizations and employer withdrawals from multiemployer plans. The following... multiemployer plans: Q-1: For purposes of this section, what are a business reorganization, a stock sale, and an... 26 Internal Revenue 17 2010-04-01 2010-04-01 false Business reorganizations and...

  18. 26 CFR 54.4980B-9 - Business reorganizations and employer withdrawals from multiemployer plans.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...-9 Business reorganizations and employer withdrawals from multiemployer plans. The following... multiemployer plans: Q-1: For purposes of this section, what are a business reorganization, a stock sale, and an... 26 Internal Revenue 17 2011-04-01 2011-04-01 false Business reorganizations and...

  19. 29 CFR Appendix A to Part 24 - Your Rights Under the Energy Reorganization Act

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Your Rights Under the Energy Reorganization Act A Appendix A... ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Pt. 24, App. A Appendix A to Part 24—Your Rights Under the Energy Reorganization Act ER18JA11.003...

  20. 26 CFR 601.503 - Requirements of power of attorney, signatures, fiduciaries and Commissioner's authority to...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 20 2011-04-01 2011-04-01 false Requirements of power of attorney, signatures... STATEMENT OF PROCEDURAL RULES Conference and Practice Requirements § 601.503 Requirements of power of...) Requirements. A power of attorney must contain the following information— (1) Name and mailing address of...

  1. 26 CFR 601.503 - Requirements of power of attorney, signatures, fiduciaries and Commissioner's authority to...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 20 2010-04-01 2010-04-01 false Requirements of power of attorney, signatures... STATEMENT OF PROCEDURAL RULES Conference and Practice Requirements § 601.503 Requirements of power of...) Requirements. A power of attorney must contain the following information— (1) Name and mailing address of...

  2. 26 CFR 601.503 - Requirements of power of attorney, signatures, fiduciaries and Commissioner's authority to...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 20 2013-04-01 2013-04-01 false Requirements of power of attorney, signatures... STATEMENT OF PROCEDURAL RULES Conference and Practice Requirements § 601.503 Requirements of power of...) Requirements. A power of attorney must contain the following information— (1) Name and mailing address of...

  3. Therapy-induced brain reorganization patterns in aphasia.

    PubMed

    Abel, Stefanie; Weiller, Cornelius; Huber, Walter; Willmes, Klaus; Specht, Karsten

    2015-04-01

    Both hemispheres are engaged in recovery from word production deficits in aphasia. Lexical therapy has been shown to induce brain reorganization even in patients with chronic aphasia. However, the interplay of factors influencing reorganization patterns still remains unresolved. We were especially interested in the relation between lesion site, therapy-induced recovery, and beneficial reorganization patterns. Thus, we applied intensive lexical therapy, which was evaluated with functional magnetic resonance imaging, to 14 chronic patients with aphasic word retrieval deficits. In a group study, we aimed to illuminate brain reorganization of the naming network in comparison with healthy controls. Moreover, we intended to analyse the data with joint independent component analysis to relate lesion sites to therapy-induced brain reorganization, and to correlate resulting components with therapy gain. As a result, we found peri-lesional and contralateral activations basically overlapping with premorbid naming networks observed in healthy subjects. Reduced activation patterns for patients compared to controls before training comprised damaged left hemisphere language areas, right precentral and superior temporal gyrus, as well as left caudate and anterior cingulate cortex. There were decreasing activations of bilateral visuo-cognitive, articulatory, attention, and language areas due to therapy, with stronger decreases for patients in right middle temporal gyrus/superior temporal sulcus, bilateral precuneus as well as left anterior cingulate cortex and caudate. The joint independent component analysis revealed three components indexing lesion subtypes that were associated with patient-specific recovery patterns. Activation decreases (i) of an extended frontal lesion disconnecting language pathways occurred in left inferior frontal gyrus; (ii) of a small frontal lesion were found in bilateral inferior frontal gyrus; and (iii) of a large temporo-parietal lesion occurred in

  4. Position Statements, Issue Briefs, Resolutions and Consensus Statements. Revised

    ERIC Educational Resources Information Center

    National Association of School Nurses (NJ1), 2012

    2012-01-01

    This article presents position statements, issue briefs, and resolutions and consensus statements of the National Association of School Nurses (NASN). The Position Statements include: (1) Allergy/Anaphylaxis Management in the School Setting; (2) Caseload Assignments; (3) Child Mortality in the School Setting; (4) Chronic Health Conditions, Managed…

  5. Axon substitution in the reorganization of developing neural connections.

    PubMed Central

    Bhide, P G; Frost, D O

    1992-01-01

    Insights into the mechanisms of normal and pathological neural development may be gained by studying the reorganization of developing neural connections, caused experimentally or by disease. Many reorganized connections are assumed to arise by the anomalous stabilization of transient connections that occur during normal development. We report that, although the retina projects transiently to the somatosensory system in normal developing hamsters, the permanent retinal projections to the somatosensory system that arise as a consequence of early brain lesions are not formed by the stabilization of the normally transient projection. Instead, the transient retinal axons are replaced by retinal axons that do not normally project to the somatosensory system. The distinction between anomalous stabilization and substitution is significant for determining the cellular mechanisms underlying the development of neural connectivity. Images PMID:1465409

  6. Ligand reorganization and activation energies in nonadiabatic electron transfer reactions

    NASA Astrophysics Data System (ADS)

    Zhu, Jianjun; Wang, Jianji; Stell, George

    2006-10-01

    The activation energy and ligand reorganization energy for nonadiabatic electron transfer reactions in chemical and biological systems are investigated in this paper. The free energy surfaces and the activation energy are derived exactly in the general case in which the ligand vibration frequencies are not equal. The activation energy is derived by free energy minimization at the transition state. Our formulation leads to the Marcus-Hush [J. Chem. Phys. 24, 979 (1956); 98, 7170 (1994); 28, 962 (1958)] results in the equal-frequency limit and also generalizes the Marcus-Sumi [J. Chem. Phys. 84, 4894 (1986)] model in the context of studying the solvent dynamic effect on electron transfer reactions. It is found that when the ligand vibration frequencies are different, the activation energy derived from the Marcus-Hush formula deviates by 5%-10% from the exact value. If the reduced reorganization energy approximation is introduced in the Marcus-Hush formula, the result is almost exact.

  7. A self-reorganizing digital flight control system for aircraft

    NASA Technical Reports Server (NTRS)

    Montgomery, R. C.; Caglayan, A. K.

    1974-01-01

    This paper presents a design method for digital self-reorganizing control systems which is optimally tolerant of failures in aircraft sensors. The functions of this system are accomplished with software instead of the popular and costly technique of hardware duplication. The theoretical development, based on M-ary hypothesis testing, results in a bank of M Kalman filters operating in parallel in the failure detection logic. A moving window of the innovations of each Kalman filter drives the detection logic to decide the failure state of the system. The detection logic also selects the optimal state estimate (for control logic) from the bank of Kalman filters. The design process is applied to the design of a self-reorganizing control system for a current configuration of the space shuttle orbiter at Mach 5 and 120,000 feet. The failure detection capabilities of the system are demonstrated using a real-time simulation of the system with noisy sensors.

  8. Be Vigilant on Financial Statements.

    ERIC Educational Resources Information Center

    Freed, DeBow

    2002-01-01

    Highlights areas on university's financial statements that warrant careful review by trustees and suggests ways they can check to see whether an institution's financial statements are clear and valid indicators of its financial status. (EV)

  9. Disability, atrophy and cortical reorganization following spinal cord injury.

    PubMed

    Freund, Patrick; Weiskopf, Nikolaus; Ward, Nick S; Hutton, Chloe; Gall, Angela; Ciccarelli, Olga; Craggs, Michael; Friston, Karl; Thompson, Alan J

    2011-06-01

    The impact of traumatic spinal cord injury on structural integrity, cortical reorganization and ensuing disability is variable and may depend on a dynamic interaction between the severity of local damage and the capacity of the brain for plastic reorganization. We investigated trauma-induced anatomical changes in the spinal cord and brain, and explored their relationship to functional changes in sensorimotor cortex. Structural changes were assessed using cross-sectional cord area, voxel-based morphometry and voxel-based cortical thickness of T1-weighted images in 10 subjects with cervical spinal cord injury and 16 controls. Cortical activation in response to right-sided (i) handgrip; and (ii) median and tibial nerve stimulation were assessed using functional magnetic resonance imaging. Regression analyses explored associations between cord area, grey and white matter volume, cortical activations and thickness, and disability. Subjects with spinal cord injury had impaired upper and lower limb function bilaterally, a 30% reduced cord area, smaller white matter volume in the pyramids and left cerebellar peduncle, and smaller grey matter volume and cortical thinning in the leg area of the primary motor and sensory cortex compared with controls. Functional magnetic resonance imaging revealed increased activation in the left primary motor cortex leg area during handgrip and the left primary sensory cortex face area during median nerve stimulation in subjects with spinal cord injury compared with controls, but no increased activation following tibial nerve stimulation. A smaller cervical cord area was associated with impaired upper limb function and increased activations with handgrip and median nerve stimulation, but reduced activations with tibial nerve stimulation. Increased sensory deficits were associated with increased activations in the left primary sensory cortex face area due to median nerve stimulation. In conclusion, spinal cord injury leads to cord atrophy

  10. Discrete Model for Inner-Sphere Reorganization of Anions.

    DTIC Science & Technology

    1986-05-01

    approaches can be followed to calculate the energy of inner-sphere reorganization in photoionization. (i) The terms not corresponding to nuclear ...motion and the outer-sphere Born solvation term are subtracted from the experimental solvation energy . (ii) Only the terms pertaining to nuclear motion...aq), respectively. The term U f(nucl) in eq. (1) represents the nuclear contribution to the solvation energy of the species A(aq) surrounded by its

  11. A reorganization cyberinfrastructure of history observing data in China

    NASA Astrophysics Data System (ADS)

    Lin, Ganghua; Ji, Haisheng; Lin, Jun; Tan, Chengmin; Du, Zhangle; Ding, Minde; Liu, Suo; Zhao, Cui; Yang, Xiao; Wang, Xiaofan; Deng, Yuanyong

    2016-08-01

    Astronomical data analysis depends on the accumulation of data, including integrity of data in observing location, time, and diversity of data. We are now developing a reorganization project of solar physics history data of China. There are 90 years, 44 kinds of solar observing data in China. In the project, we will finish imagination, digitalization and standardization of these data. This article introduces the project framework, data, data processing, and how to share.

  12. In Brief: Re-organization of NSF's Earth sciences

    NASA Astrophysics Data System (ADS)

    Jacobs, Judy

    2004-07-01

    The U.S. National Science Foundation announced July 16 that its Division of Earth Sciences would be re-organized into two new Sections. The Surface Earth Processes Section (SEP) will consists of the programs in hydrology (HS), education and human resources (EHR), sedimentary geology and paleobiology (SGP), geobiology and environmental geochemistry (GEG), and geomorphology and land use dynamics (GLD). The current budget for the new section is approximately $50 million per year.

  13. Forelimb training drives transient map reorganization in ipsilateral motor cortex.

    PubMed

    Pruitt, David T; Schmid, Ariel N; Danaphongse, Tanya T; Flanagan, Kate E; Morrison, Robert A; Kilgard, Michael P; Rennaker, Robert L; Hays, Seth A

    2016-10-15

    Skilled motor training results in reorganization of contralateral motor cortex movement representations. The ipsilateral motor cortex is believed to play a role in skilled motor control, but little is known about how training influences reorganization of ipsilateral motor representations of the trained limb. To determine whether training results in reorganization of ipsilateral motor cortex maps, rats were trained to perform the isometric pull task, an automated motor task that requires skilled forelimb use. After either 3 or 6 months of training, intracortical microstimulation (ICMS) mapping was performed to document motor representations of the trained forelimb in the hemisphere ipsilateral to that limb. Motor training for 3 months resulted in a robust expansion of right forelimb representation in the right motor cortex, demonstrating that skilled motor training drives map plasticity ipsilateral to the trained limb. After 6 months of training, the right forelimb representation in the right motor cortex was significantly smaller than the representation observed in rats trained for 3 months and similar to untrained controls, consistent with a normalization of motor cortex maps. Forelimb map area was not correlated with performance on the trained task, suggesting that task performance is maintained despite normalization of cortical maps. This study provides new insights into how the ipsilateral cortex changes in response to skilled learning and may inform rehabilitative strategies to enhance cortical plasticity to support recovery after brain injury.

  14. A molecularly based theory for electron transfer reorganization energy.

    PubMed

    Zhuang, Bilin; Wang, Zhen-Gang

    2015-12-14

    Using field-theoretic techniques, we develop a molecularly based dipolar self-consistent-field theory (DSCFT) for charge solvation in pure solvents under equilibrium and nonequilibrium conditions and apply it to the reorganization energy of electron transfer reactions. The DSCFT uses a set of molecular parameters, such as the solvent molecule's permanent dipole moment and polarizability, thus avoiding approximations that are inherent in treating the solvent as a linear dielectric medium. A simple, analytical expression for the free energy is obtained in terms of the equilibrium and nonequilibrium electrostatic potential profiles and electric susceptibilities, which are obtained by solving a set of self-consistent equations. With no adjustable parameters, the DSCFT predicts activation energies and reorganization energies in good agreement with previous experiments and calculations for the electron transfer between metallic ions. Because the DSCFT is able to describe the properties of the solvent in the immediate vicinity of the charges, it is unnecessary to distinguish between the inner-sphere and outer-sphere solvent molecules in the calculation of the reorganization energy as in previous work. Furthermore, examining the nonequilibrium free energy surfaces of electron transfer, we find that the nonequilibrium free energy is well approximated by a double parabola for self-exchange reactions, but the curvature of the nonequilibrium free energy surface depends on the charges of the electron-transferring species, contrary to the prediction by the linear dielectric theory.

  15. A molecularly based theory for electron transfer reorganization energy

    SciTech Connect

    Zhuang, Bilin; Wang, Zhen-Gang

    2015-12-14

    Using field-theoretic techniques, we develop a molecularly based dipolar self-consistent-field theory (DSCFT) for charge solvation in pure solvents under equilibrium and nonequilibrium conditions and apply it to the reorganization energy of electron transfer reactions. The DSCFT uses a set of molecular parameters, such as the solvent molecule’s permanent dipole moment and polarizability, thus avoiding approximations that are inherent in treating the solvent as a linear dielectric medium. A simple, analytical expression for the free energy is obtained in terms of the equilibrium and nonequilibrium electrostatic potential profiles and electric susceptibilities, which are obtained by solving a set of self-consistent equations. With no adjustable parameters, the DSCFT predicts activation energies and reorganization energies in good agreement with previous experiments and calculations for the electron transfer between metallic ions. Because the DSCFT is able to describe the properties of the solvent in the immediate vicinity of the charges, it is unnecessary to distinguish between the inner-sphere and outer-sphere solvent molecules in the calculation of the reorganization energy as in previous work. Furthermore, examining the nonequilibrium free energy surfaces of electron transfer, we find that the nonequilibrium free energy is well approximated by a double parabola for self-exchange reactions, but the curvature of the nonequilibrium free energy surface depends on the charges of the electron-transferring species, contrary to the prediction by the linear dielectric theory.

  16. Relatives' Responsibility; Policy Statement.

    ERIC Educational Resources Information Center

    American Foundation for the Blind, New York, NY.

    Presented by the American Foundation for the Blind (AFB) are background information and a policy statement on responsibility laws pertaining to relatives of applicants for public assistance. The laws are said to date to the Elizabethan Poor Laws, to vary state to state, and to mandate eligibility for public assistance on requirements of residence,…

  17. Youth Employment. Policy Statement.

    ERIC Educational Resources Information Center

    National Collaboration for Youth, Washington, DC.

    This paper presents the policy statement on youth employment from the National Collaboration for Youth (NCY). An introduction briefly explains the role of the NCY with regard to youth employment and describes the types of programs and services supported by NCY. A section on background provides statistics on teenagers and employment from the Bureau…

  18. Sustainability Statement and Policy

    ERIC Educational Resources Information Center

    Journal of Education for Sustainable Development, 2009

    2009-01-01

    This article presents nine resources that focus on environmental education and sustainability. These include: (1) "Sustainability Statement and Policy," Dalhousie University, Nova Scotia, Canada, 2009, which is available at http://office.sustainability.dal.ca/Governance; (2) "Climate Literacy: The Essential Principles of Climate…

  19. Institutional VVM Statements on Websites

    ERIC Educational Resources Information Center

    Calder, Wm. B.

    2011-01-01

    Educational leaders rely on compelling statements of institutional beliefs, strategic direction, and purpose (i.e., values, vision, and mission statements or VVM statements) as the three major pillars by which to launch new program/service initiatives, to enhance academic and administrative operations, and to chart sustainable options in building…

  20. Priorities Statements of Community Colleges.

    ERIC Educational Resources Information Center

    Illinois Community Coll. Board, Springfield.

    Each year since 1994, the 52 community colleges in Illinois prepare priority statements detailing specific college objectives for the current fiscal year (FY). This report provides the third update of the colleges' statements, covering FY 1998. Brief statements, from one to four pages, are provided for the following colleges: Belleville Area…

  1. 3 CFR - Presidential Signing Statements

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 3 The President 1 2010-01-01 2010-01-01 false Presidential Signing Statements Presidential Documents Other Presidential Documents Memorandum of March 9, 2009 Presidential Signing Statements Memorandum for the Heads of Executive Departments and Agencies For nearly two centuries, Presidents have issued statements addressing constitutional or...

  2. Treatment provider's knowledge of the Health and Disability Commissioner's Code of Consumer Rights.

    PubMed

    Townshend, Philip L; Sellman, J Douglas

    2002-06-01

    The Health and Disability Commissioner's (HDC) Code of Health and and Disability Consumers' Rights (the Code) defines in law the rights of consumers of health and disability services in New Zealand. In the first few years after the publication health educators, service providers and the HDC extensively promoted the Code. Providers of health and disability services would be expected to be knowledgeable about the areas covered by the Code if it is routinely used in the development and monitoring of treatment plans. In this study knowledge of the Code was tested in a random sample of 217 clinical staff that included medical staff, psychologists and counsellors working in Alcohol and Drug Treatment (A&D) centres in New Zealand. Any response showing awareness of a right, regardless of wording, was taken as a positive response as it was the areas covered by rights rather than their actual wording that was considered to be the important knowledge for providers. The main finding of this research was that 23% of staff surveyed were aware of none of the ten rights in the Code and only 6% were aware of more than five of the ten rights. Relating these data to results from a wider sample of treatment providers raises the possibility that A&D treatment providers are slightly more aware of the content of the Code than a general sample of health and disability service providers however overall awareness of the content of the Code by health providers is very low. These results imply that consumer rights issues are not prominent in the minds of providers perhaps indicating an ethical blind spot on their part. Ignorance of the content of the Code may indicate that the treatment community do not find it a useful working document or alternatively that clinicians are content to rely on their own good intentions to preserve the rights of their patients. Further research will be required to explain this lack of knowledge, however the current situation is that consumers cannot rely on

  3. Statement of Intent

    ERIC Educational Resources Information Center

    Walter, Charmian

    2008-01-01

    The purpose of writing a charter is to show adult learners that the people providing learning for them are willing to sign up publicly to a statement of their entitlement to the very best quality of information, guidance, teaching and support--and not only to sign up to it, but to be ready to be called to account if they do not live up to the…

  4. Episodic tectonic plate reorganizations driven by mantle convection

    NASA Astrophysics Data System (ADS)

    King, Scott D.; Lowman, Julian P.; Gable, Carl W.

    2002-10-01

    Periods of relatively uniform plate motion were interrupted several times throughout the Cenozoic and Mesozoic by rapid plate reorganization events [R. Hey, Geol. Soc. Am. Bull. 88 (1977) 1404-1420; P.A. Rona, E.S. Richardson, Earth Planet. Sci. Lett. 40 (1978) 1-11; D.C. Engebretson, A. Cox, R.G. Gordon, Geol. Soc. Am. Spec. Pap. 206 (1985); R.G. Gordon, D.M. Jurdy, J. Geophys. Res. 91 (1986) 12389-12406; D.A. Clague, G.B. Dalrymple, US Geol. Surv. Prof. Pap. 1350 (1987) 5-54; J.M. Stock, P. Molnar, Nature 325 (1987) 495-499; C. Lithgow-Bertelloni, M.A. Richards, Geophys. Res. Lett. 22 (1995) 1317-1320; M.A. Richards, C. Lithgow-Bertelloni, Earth Planet. Sci. Lett. 137 (1996) 19-27; C. Lithgow-Bertelloni, M.A. Richards, Rev. Geophys. 36 (1998) 27-78]. It has been proposed that changes in plate boundary forces are responsible for these events [M.A. Richards, C. Lithgow-Bertelloni, Earth Planet. Sci. Lett. 137 (1996) 19-27; C. Lithgow-Bertelloni, M.A. Richards, Rev. Geophys. 36 (1998) 27-78]. We present an alternative hypothesis: convection-driven plate motions are intrinsically unstable due to a buoyant instability that develops as a result of the influence of plates on an internally heated mantle. This instability, which has not been described before, is responsible for episodic reorganizations of plate motion. Numerical mantle convection experiments demonstrate that high-Rayleigh number convection with internal heating and surface plates is sufficient to induce plate reorganization events, changes in plate boundary forces, or plate geometry, are not required.

  5. Epiplakin attenuates experimental mouse liver injury by chaperoning keratin reorganization

    PubMed Central

    Szabo, Sandra; Wögenstein, Karl L.; Österreicher, Christoph H.; Guldiken, Nurdan; Chen, Yu; Doler, Carina; Wiche, Gerhard; Boor, Peter; Haybaeck, Johannes; Strnad, Pavel; Fuchs, Peter

    2015-01-01

    Background & Aims Epiplakin is a member of the plakin protein family and exclusively expressed in epithelial tissues where it binds to keratins. Epiplakin-deficient (Eppk1−/−) mice displayed no obvious spontaneous phenotype, but their keratinocytes showed a faster keratin network breakdown in response to stress. The role of epiplakin in the stressed liver remained to be elucidated. Methods Wild-type (WT) and Eppk1−/− mice were subjected to common bile duct ligation (CBDL) or fed with a 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-containing diet. The importance of epiplakin during keratin reorganization was assessed in primary hepatocytes. Results Our experiments revealed that epiplakin is expressed in hepatocytes and cholangiocytes, and binds to keratin 8 (K8) and K18 via multiple domains. In several liver stress models epiplakin and K8 genes displayed identical expression patterns and transgenic K8 overexpression resulted in elevated hepatic epiplakin levels. After CBDL and DDC treatment, Eppk1−/− mice developed a more pronounced liver injury and their livers contained larger amounts of hepatocellular keratin granules, indicating impaired disease-induced keratin network reorganization. In line with these findings, primary Eppk1−/− hepatocytes showed increased formation of keratin aggregates after treatment with the phosphatase inhibitor okadaic acid, a phenotype which was rescued by the chemical chaperone trimethylamine N-oxide (TMAO). Finally, transfection experiments revealed that Eppk1−/− primary hepatocytes were less able to tolerate forced K8 overexpression and that TMAO treatment rescued this phenotype. Conclusion Our data indicate that epiplakin plays a protective role during experimental liver injuries by chaperoning disease-induced keratin reorganization. PMID:25617501

  6. Cortical reorganization in patients with cervical spondylotic myelopathy

    PubMed Central

    Holly, Langston T.; Dong, Yun; Albistegui-DuBois, Richard; Marehbian, Jonathan; Dobkin, Bruce

    2014-01-01

    Object Recent investigations have demonstrated that the cerebral cortex can reorganize as a result of spinal cord injury and may play a role in preserving neurological function. Reorganization of cortical representational maps in patients with cervical spondylotic myelopathy (CSM) has not been previously described. The authors sought to determine the feasibility of using functional magnetic resonance (fMR) imaging in patients with CSM to investigate changes in the cortical representation of the wrist and ankle before and after surgical intervention. Methods Four patients with clinical and imaging evidence of CSM were prospectively enrolled in this study. The patients underwent preoperative neurological examination, functional assessment, cervical imaging, and brain fMR imaging. The fMR imaging activation task undertaken was either wrist extension or ankle dorsiflexion, depending on whether the patient's primary impairment was hand dysfunction or gait difficulty. The cohort then underwent further evaluations at 6 weeks and 3 and 6 months postoperatively. In addition, five healthy volunteers underwent fMR imaging at two different time points and served as controls. In the healthy volunteers fMR imaging demonstrated areas of focal cortical activation limited to the contralateral primary motor area for the assigned motor tasks; the activation patterns were stable throughout repeated imaging. In comparison, in patients with CSM fMR imaging demonstrated expansion of the cortical representation of the affected extremity. Surgical decompression resulted in improvements in neurological function and reorganization of the representational map. Conclusions The findings of this preliminary study demonstrate the potential of fMR imaging to assess changes in cortical representation before and after surgical intervention in patients with CSM. A future study involving a larger cohort of patients as well as the stratification of patients with CSM, based on the aforementioned factors

  7. Cortical reorganization in multiple sclerosis after intrathecal baclofen therapy.

    PubMed

    Guerrera, S; Morabito, R; Baglieri, A; Corallo, F; Ciurleo, R; De Luca, R; De Salvo, S; Marino, M A; Spadaro, L; Timpano, F; Bramanti, P; Marino, S

    2014-04-01

    Our objective was to assess the role of Intrathecal Baclofen Therapy (ITB) in the cortical reorganization in a patient affected by multiple sclerosis (MS) undergoing physical therapy. We reported a case of a woman affected by MS and severe spasticity, who performed an fMRI examination, before and after the ITB implantation. The subject showed controlateral motor cortex activation after motor task. After a month of ITB implantation, patient showed ipsilateral and controlateral motor cortex activation although with a broader extension. fMRI examination supported the hypothesis of a central influence in patients who undergo physiotherapy and therapy with ITB.

  8. Plasma membrane reorganization induced by chemical transformation in cultura

    SciTech Connect

    Packard, B.S.

    1984-04-01

    Induction of increased rigidity in the plasma membrane paralleling properties associated with a transformed state was suggested by two experiments. Fluorescence recovery after photobleaching (FRAP) indicated the induction of an environment in the plasma membrane where the synthetic fluorescent phospholipid collarein was immobile on the FRAP timescale. The other technique revealed the binding of epidermal growth factor (EGF) to a cryptic class of receptors which become accessible upon chemical transformation. These two lines of evidence are consistent with a reorganization of the plasma membrane induced by tumor promoters. 110 references, 38 figures, 4 tables.

  9. Global Dynamic Numerical Simulations of Plate Tectonic Reorganizations

    NASA Astrophysics Data System (ADS)

    Morra, G.; Quevedo, L.; Butterworth, N.; Matthews, K. J.; Müller, D.

    2010-12-01

    We use a new numerical approach for global geodynamics to investigate the origin of present global plate motion and to identify the causes of the last two global tectonic reorganizations occurred about 50 and 100 million years ago (Ma) [1]. While the 50 Ma event is the most well-known global plate-mantle event, expressed by the bend in the Hawaiian-Emperor volcanic chain, a prominent plate reorganization at about 100 Ma, although presently little studied, is clearly indicated by a major bend in the fracture zones in the Indian Ocean and by a change in Pacific plate motion [2]. Our workflow involves turning plate reconstructions into surface meshes that are subsequently employed as initial conditions for global Boundary Element numerical models. The tectonic setting that anticipates the reorganizations is processed with the software GPlates, combining the 3D mesh of the paleo-plate morphology and the reconstruction of paleo-subducted slabs, elaborated from tectonic history [3]. All our models involve the entire planetary system, are fully dynamic, have free surface, are characterized by a spectacular computational speed due to the simultaneous use of the multi-pole algorithm and the Boundary Element formulation and are limited only by the use of sharp material property variations [4]. We employ this new tool to unravel the causes of plate tectonic reorganizations, producing and comparing global plate motion with the reconstructed ones. References: [1] Torsvik, T., Müller, R.D., Van der Voo, R., Steinberger, B., and Gaina, C., 2008, Global Plate Motion Frames: Toward a unified model: Reviews in Geophysics, VOL. 46, RG3004, 44 PP., 2008 [2] Wessel, P. and Kroenke, L.W. Pacific absolute plate motion since 145 Ma: An assessment of the fixed hot spot hypothesis. Journal of Geophysical Research, Vol 113, B06101, 2008 [3] L. Quevedo, G. Morra, R. D. Mueller. Parallel Fast Multipole Boundary Element Method for Crustal Dynamics, Proceeding 9th World Congress and 4th Asian

  10. Self-repairing symmetry in jellyfish through mechanically driven reorganization

    PubMed Central

    Abrams, Michael J.; Basinger, Ty; Yuan, William; Guo, Chin-Lin; Goentoro, Lea

    2015-01-01

    What happens when an animal is injured and loses important structures? Some animals simply heal the wound, whereas others are able to regenerate lost parts. In this study, we report a previously unidentified strategy of self-repair, where moon jellyfish respond to injuries by reorganizing existing parts, and rebuilding essential body symmetry, without regenerating what is lost. Specifically, in response to arm amputation, the young jellyfish of Aurelia aurita rearrange their remaining arms, recenter their manubria, and rebuild their muscular networks, all completed within 12 hours to 4 days. We call this process symmetrization. We find that symmetrization is not driven by external cues, cell proliferation, cell death, and proceeded even when foreign arms were grafted on. Instead, we find that forces generated by the muscular network are essential. Inhibiting pulsation using muscle relaxants completely, and reversibly, blocked symmetrization. Furthermore, we observed that decreasing pulse frequency using muscle relaxants slowed symmetrization, whereas increasing pulse frequency by lowering the magnesium concentration in seawater accelerated symmetrization. A mathematical model that describes the compressive forces from the muscle contraction, within the context of the elastic response from the mesoglea and the ephyra geometry, can recapitulate the recovery of global symmetry. Thus, self-repair in Aurelia proceeds through the reorganization of existing parts, and is driven by forces generated by its own propulsion machinery. We find evidence for symmetrization across species of jellyfish (Chrysaora pacifica, Mastigias sp., and Cotylorhiza tuberculata). PMID:26080418

  11. Retinotopically specific reorganization of visual cortex for tactile pattern recognition

    PubMed Central

    Cheung, Sing-Hang; Fang, Fang; He, Sheng; Legge, Gordon E.

    2009-01-01

    Although previous studies have shown that Braille reading and other tactile-discrimination tasks activate the visual cortex of blind and sighted people [1–5], it is not known whether this kind of cross-modal reorganization is influenced by retinotopic organization. We have addressed this question by studying S, a visually impaired adult with the rare ability to read print visually and Braille by touch. S had normal visual development until age six years, and thereafter severe acuity reduction due to corneal opacification, but no evidence of visual-field loss. Functional magnetic resonance imaging (fMRI) revealed that, in S’s early visual areas, tactile information processing activated what would be the foveal representation for normally-sighted individuals, and visual information processing activated what would be the peripheral representation. Control experiments showed that this activation pattern was not due to visual imagery. S’s high-level visual areas which correspond to shape- and object-selective areas in normally-sighted individuals were activated by both visual and tactile stimuli. The retinotopically specific reorganization in early visual areas suggests an efficient redistribution of neural resources in the visual cortex. PMID:19361999

  12. From network structure to network reorganization: implications for adult neurogenesis

    NASA Astrophysics Data System (ADS)

    Schneider-Mizell, Casey M.; Parent, Jack M.; Ben-Jacob, Eshel; Zochowski, Michal R.; Sander, Leonard M.

    2010-12-01

    Networks can be dynamical systems that undergo functional and structural reorganization. One example of such a process is adult hippocampal neurogenesis, in which new cells are continuously born and incorporate into the existing network of the dentate gyrus region of the hippocampus. Many of these introduced cells mature and become indistinguishable from established neurons, joining the existing network. Activity in the network environment is known to promote birth, survival and incorporation of new cells. However, after epileptogenic injury, changes to the connectivity structure around the neurogenic niche are known to correlate with aberrant neurogenesis. The possible role of network-level changes in the development of epilepsy is not well understood. In this paper, we use a computational model to investigate how the structural and functional outcomes of network reorganization, driven by addition of new cells during neurogenesis, depend on the original network structure. We find that there is a stable network topology that allows the network to incorporate new neurons in a manner that enhances activity of the persistently active region, but maintains global network properties. In networks having other connectivity structures, new cells can greatly alter the distribution of firing activity and destroy the initial activity patterns. We thus find that new cells are able to provide focused enhancement of network only for small-world networks with sufficient inhibition. Network-level deviations from this topology, such as those caused by epileptogenic injury, can set the network down a path that develops toward pathological dynamics and aberrant structural integration of new cells.

  13. Dynamic reorganization of brain functional networks during cognition.

    PubMed

    Bola, Michał; Sabel, Bernhard A

    2015-07-01

    How does cognition emerge from neural dynamics? The dominant hypothesis states that interactions among distributed brain regions through phase synchronization give basis for cognitive processing. Such phase-synchronized networks are transient and dynamic, established on the timescale of milliseconds in order to perform specific cognitive operations. But unlike resting-state networks, the complex organization of transient cognitive networks is typically not characterized within the graph theory framework. Thus, it is not known whether cognitive processing merely changes the strength of functional connections or, conversely, requires qualitatively new topological arrangements of functional networks. To address this question, we recorded high-density EEG while subjects performed a visual discrimination task. We conducted an event-related network analysis (ERNA) where source-space weighted functional networks were characterized with graph measures. ERNA revealed rapid, transient, and frequency-specific reorganization of the network's topology during cognition. Specifically, cognitive networks were characterized by strong clustering, low modularity, and strong interactions between hub-nodes. Our findings suggest that dense and clustered connectivity between the hub nodes belonging to different modules is the "network fingerprint" of cognition. Such reorganization patterns might facilitate global integration of information and provide a substrate for a "global workspace" necessary for cognition and consciousness to occur. Thus, characterizing topology of the event-related networks opens new vistas to interpret cognitive dynamics in the broader conceptual framework of graph theory.

  14. Nanoscale Molecular Reorganization of the Inhibitory Postsynaptic Density Is a Determinant of GABAergic Synaptic Potentiation.

    PubMed

    Pennacchietti, Francesca; Vascon, Sebastiano; Nieus, Thierry; Rosillo, Christian; Das, Sabyasachi; Tyagarajan, Shiva K; Diaspro, Alberto; Del Bue, Alessio; Petrini, Enrica Maria; Barberis, Andrea; Cella Zanacchi, Francesca

    2017-02-15

    Gephyrin is a key scaffold protein mediating the anchoring of GABAA receptors at inhibitory synapses. Here, we exploited superresolution techniques combined with proximity-based clustering analysis and model simulations to investigate the single-molecule gephyrin reorganization during plasticity of inhibitory synapses in mouse hippocampal cultured neurons. This approach revealed that, during the expression of inhibitory LTP, the increase of gephyrin density at postsynaptic sites is associated with the promoted formation of gephyrin nanodomains. We demonstrate that the gephyrin rearrangement in nanodomains stabilizes the amplitude of postsynaptic currents, indicating that, in addition to the number of synaptic GABAA receptors, the nanoscale distribution of GABAA receptors in the postsynaptic area is a crucial determinant for the expression of inhibitory synaptic plasticity. In addition, the methodology implemented here clears the way to the application of the graph-based theory to single-molecule data for the description and quantification of the spatial organization of the synapse at the single-molecule level.SIGNIFICANCE STATEMENT The mechanisms of inhibitory synaptic plasticity are poorly understood, mainly because the size of the synapse is below the diffraction limit, thus reducing the effectiveness of conventional optical and imaging techniques. Here, we exploited superresolution approaches combined with clustering analysis to study at unprecedented resolution the distribution of the inhibitory scaffold protein gephyrin in response to protocols inducing LTP of inhibitory synaptic responses (iLTP). We found that, during the expression of iLTP, the increase of synaptic gephyrin is associated with the fragmentation of gephyrin in subsynaptic nanodomains. We demonstrate that such synaptic gephyrin nanodomains stabilize the amplitude of inhibitory postsynaptic responses, thus identifying the nanoscale gephyrin rearrangement as a key determinant for inhibitory

  15. Position statement on cannabis.

    PubMed

    Stein For The Executive Committee Of The Central Drug Authority, Dan Joseph

    2016-05-16

    There is an ongoing national debate around cannabis policy. This brief position statement by the Executive Committee of the Central Drug Authorityoutlines some of the factors that have contributed to this debate, delineates reduction strategies, summarises the harms and benefits ofmarijuana, and provides recommendations. These recommendations emphasise an integrated and evidence-based approach, the need forresources to implement harm reduction strategies against continued and chronic use of alcohol and cannabis, and the potential value of afocus on decriminalisation rather than the legalisation of cannabis.

  16. Statement on virginity testing.

    PubMed

    2015-07-01

    Virginity testing (virginity examination) is a gynecological examination that is intended to correlate the status and appearance of the hymen with previous sexual contact to determine whether a female has had or is habituated to sexual intercourse. Virginity examinations are practiced in many countries, often forcibly, including in detention places; on women who allege rape or are accused of prostitution; and as part of public or social policies to control sexuality. The Independent Forensic Expert Group (IFEG) - thirty-five preeminent independent forensic experts from eighteen countries specialized in evaluating and documenting the physical and psychological effects of torture and ill-treatment - released a statement on the practice in December 2014. In its statement, the IFEG outlines the physical and psychological effects of forcibly conducting virginity examinations on females based on its collective experience. The Group assesses whether, based on the effects, forcibly conducted virginity examinations constitute cruel, inhuman, or degrading treatment or torture. Finally, the IFEG addresses the medical interpretation, relevance, and ethical implications of such examinations. The IFEG concludes that virginity examinations are medically unreliable and have no clinical or scientific value. These examinations are inherently discriminatory and, in almost all instances, when conducted forcibly, result in significant physical and mental pain and suffering, thereby constituting cruel, inhuman and degrading treatment or torture. When virginity examinations are forcibly conducted and involve vaginal penetration, the examination should be considered as sexual assault and rape. Involvement of health professionals in these examinations violates the basic standards and ethics of the professions.

  17. Pediatrician workforce policy statement.

    PubMed

    Basco, William T; Rimsza, Mary E

    2013-08-01

    This policy statement reviews important trends and other factors that affect the pediatrician workforce and the provision of pediatric health care, including changes in the pediatric patient population, pediatrician workforce, and nature of pediatric practice. The effect of these changes on pediatricians and the demand for pediatric care are discussed. The American Academy of Pediatrics (AAP) concludes that there is currently a shortage of pediatric medical subspecialists in many fields, as well as a shortage of pediatric surgical specialists. In addition, the AAP believes that the current distribution of primary care pediatricians is inadequate to meet the needs of children living in rural and other underserved areas, and more primary care pediatricians will be needed in the future because of the increasing number of children who have significant chronic health problems, changes in physician work hours, and implementation of current health reform efforts that seek to improve access to comprehensive patient- and family-centered care for all children in a medical home. The AAP is committed to being an active participant in physician workforce policy development with both professional organizations and governmental bodies to ensure a pediatric perspective on health care workforce issues. The overall purpose of this statement is to summarize policy recommendations and serve as a resource for the AAP and other stakeholders as they address pediatrician workforce issues that ultimately influence the quality of pediatric health care provided to children in the United States.

  18. Aerospace Education. NSTA Position Statement

    ERIC Educational Resources Information Center

    National Science Teachers Association (NJ1), 2008

    2008-01-01

    National Science Teachers Association (NSTA) has developed a new position statement, "Aerospace Education." NSTA believes that aerospace education is an important component of comprehensive preK-12 science education programs. This statement highlights key considerations that should be addressed when implementing a high quality aerospace education…

  19. Commentary on Causal Prescriptive Statements

    ERIC Educational Resources Information Center

    Graesser, Arthur C.; Hu, Xiangen

    2011-01-01

    Causal prescriptive statements are valued in the social sciences when there is the goal of helping people through interventions. The articles in this special issue cover different methods for testing causal prescriptive statements. This commentary identifies both virtues and liabilities of these different approaches. We argue that it is extremely…

  20. Priorities Statements of Community Colleges.

    ERIC Educational Resources Information Center

    Illinois Community Coll. Board, Springfield.

    In response to recommendations in the Illinois Board of Higher Education's Priorities, Quality, and Productivity report of November 1994, the 52 community colleges in the state prepared priority statements detailing specific college objectives for the current fiscal year (FY). This report provides the second update of the colleges' statements,…

  1. 29 CFR Appendix A to Part 24 - Your Rights Under the Energy Reorganization Act

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Your Rights Under the Energy Reorganization Act A Appendix A to Part 24 Labor Office of the Secretary of Labor PROCEDURES FOR THE HANDLING OF RETALIATION... ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Pt. 24, App. A Appendix A to Part 24—Your Rights Under...

  2. 29 CFR Appendix A to Part 24 - Your Rights Under the Energy Reorganization Act

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Your Rights Under the Energy Reorganization Act A Appendix A to Part 24 Labor Office of the Secretary of Labor PROCEDURES FOR THE HANDLING OF RETALIATION... the Energy Reorganization Act ER10AU07.000...

  3. 26 CFR 1.167(l)-3 - Multiple regulation, asset acquisitions, reorganizations, etc.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., reorganizations, etc. 1.167(l)-3 Section 1.167(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... and Corporations § 1.167(l)-3 Multiple regulation, asset acquisitions, reorganizations, etc. (a... uses a method of depreciation other than a subsection (l) method of depreciation is required by...

  4. 26 CFR 1.167(l)-3 - Multiple regulation, asset acquisitions, reorganizations, etc.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., reorganizations, etc. 1.167(l)-3 Section 1.167(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... and Corporations § 1.167(l)-3 Multiple regulation, asset acquisitions, reorganizations, etc. (a... uses a method of depreciation other than a subsection (l) method of depreciation is required by...

  5. 26 CFR 1.167(l)-3 - Multiple regulation, asset acquisitions, reorganizations, etc.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., reorganizations, etc. 1.167(l)-3 Section 1.167(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... and Corporations § 1.167(l)-3 Multiple regulation, asset acquisitions, reorganizations, etc. (a... uses a method of depreciation other than a subsection (l) method of depreciation is required by...

  6. 26 CFR 1.167(l)-3 - Multiple regulation, asset acquisitions, reorganizations, etc.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., reorganizations, etc. 1.167(l)-3 Section 1.167(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... and Corporations § 1.167(l)-3 Multiple regulation, asset acquisitions, reorganizations, etc. (a... uses a method of depreciation other than a subsection (l) method of depreciation is required by...

  7. 26 CFR 1.167(l)-3 - Multiple regulation, asset acquisitions, reorganizations, etc.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., reorganizations, etc. 1.167(l)-3 Section 1.167(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... and Corporations § 1.167(l)-3 Multiple regulation, asset acquisitions, reorganizations, etc. (a... uses a method of depreciation other than a subsection (l) method of depreciation is required by...

  8. 75 FR 17692 - Foreign-Trade Zone 75 -- Phoenix, Arizona, Application for Reorganization under Alternative Site...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-07

    ... Foreign-Trade Zones Board Foreign-Trade Zone 75 -- Phoenix, Arizona, Application for Reorganization under...) by the City of the Phoenix, grantee of FTZ 75, requesting authority to reorganize the zone under the...-acre Phoenix Sky Harbor Center and adjacent air cargo terminal at the Phoenix Sky Harbor...

  9. 77 FR 65361 - Reorganization/Expansion of Foreign-z Under Alternative Site Framework; Galveston, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-26

    ...; Galveston, TX Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U... or reorganization of zones; Whereas, the Board of Trustees of the Galveston Wharves, grantee of... authority to reorganize under the ASF with a service area of Galveston County, Texas, within and adjacent...

  10. Strategies for Reorganization in Allied Health and Nursing Programs: The Endless Metamorphosis.

    ERIC Educational Resources Information Center

    Scigliano, Virginia; Scigliano, John A.

    Four alternative organizational structures are discussed with regard to their applicability to the reorganization of community college allied health programs. After introductory material noting the complexities, multiple interfaces, and high costs that make allied health and nursing programs prime targets for reorganization, the four models of…

  11. 78 FR 60695 - Regulatory Reorganization; Administrative Changes to Regulations Due to the Consolidation of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ... Reorganization; Administrative Changes to Regulations Due to the Consolidation of the Financial Management... consolidated the bureaus formerly known as the Financial Management Service (``FMS'') and the Bureau of the... consolidation requires reorganization of, and administrative changes to, title 31 of the Code of...

  12. 77 FR 6059 - Reorganization of Foreign-Trade Zone 275 Under Alternative Site Framework; Lansing, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... Foreign-Trade Zones Board Reorganization of Foreign-Trade Zone 275 Under Alternative Site Framework... Board adopted the alternative site framework (ASF) (74 FR 1170, 01/12/09; correction 74 FR 3987, 01/22... to reorganize FTZ 275 under the alternative site framework is approved, subject to the FTZ Act...

  13. 77 FR 6058 - Reorganization of Foreign-Trade Zone 118 Under Alternative Site Framework, Ogdensburg, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... Foreign-Trade Zones Board Reorganization of Foreign-Trade Zone 118 Under Alternative Site Framework... Board adopted the alternative site framework (ASF) (74 FR 1170, 01/12/2009; correction 74 FR 3987, 01/22... to reorganize FTZ 118 under the alternative site framework is approved, subject to the FTZ Act...

  14. 26 CFR 1.358-6 - Stock basis in certain triangular reorganizations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... purposes of this section— (i) P is a corporation— (A) That is a party to a reorganization, (B) That is in... reorganization, and (B) That is controlled by P. (iii) T is a corporation that is another party to the...) directly from T in a transaction in which P's basis in the T assets was determined under section...

  15. 26 CFR 1.358-6 - Stock basis in certain triangular reorganizations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... purposes of this section— (i) P is a corporation— (A) That is a party to a reorganization, (B) That is in... reorganization, and (B) That is controlled by P. (iii) T is a corporation that is another party to the...) directly from T in a transaction in which P's basis in the T assets was determined under section...

  16. 26 CFR 1.358-6 - Stock basis in certain triangular reorganizations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... purposes of this section— (i) P is a corporation— (A) That is a party to a reorganization, (B) That is in... reorganization, and (B) That is controlled by P. (iii) T is a corporation that is another party to the...) directly from T in a transaction in which P's basis in the T assets was determined under section...

  17. 29 CFR 24.114 - District court jurisdiction of retaliation complaints under the Energy Reorganization Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Provisions § 24.114 District court jurisdiction of retaliation complaints under the Energy Reorganization Act... 29 Labor 1 2010-07-01 2010-07-01 true District court jurisdiction of retaliation complaints under the Energy Reorganization Act. 24.114 Section 24.114 Labor Office of the Secretary of Labor...

  18. Hunting promotes spatial reorganization and sexually selected infanticide

    PubMed Central

    Leclerc, M.; Frank, S. C.; Zedrosser, A.; Swenson, J. E.; Pelletier, F.

    2017-01-01

    Harvest can affect the ecology and evolution of wild species. The removal of key individuals, such as matriarchs or dominant males, can disrupt social structure and exacerbate the impact of hunting on population growth. We do not know, however, how and when the spatiotemporal reorganization takes place after removal and if such changes can be the mechanism that explain a decrease in population growth. Detailed behavioral information from individually monitored brown bears, in a population where hunting increases sexually selected infanticide, revealed that adult males increased their use of home ranges of hunter-killed neighbors in the second year after their death. Use of a hunter-killed male’s home range was influenced by the survivor’s as well as the hunter-killed male’s age, population density, and hunting intensity. Our results emphasize that hunting can have long-term indirect effects which can affect population viability. PMID:28332613

  19. Reorganization between preparatory and movement population responses in motor cortex

    PubMed Central

    Elsayed, Gamaleldin F.; Lara, Antonio H.; Kaufman, Matthew T.; Churchland, Mark M.; Cunningham, John P.

    2016-01-01

    Neural populations can change the computation they perform on very short timescales. Although such flexibility is common, the underlying computational strategies at the population level remain unknown. To address this gap, we examined population responses in motor cortex during reach preparation and movement. We found that there exist exclusive and orthogonal population-level subspaces dedicated to preparatory and movement computations. This orthogonality yielded a reorganization in response correlations: the set of neurons with shared response properties changed completely between preparation and movement. Thus, the same neural population acts, at different times, as two separate circuits with very different properties. This finding is not predicted by existing motor cortical models, which predict overlapping preparation-related and movement-related subspaces. Despite orthogonality, responses in the preparatory subspace were lawfully related to subsequent responses in the movement subspace. These results reveal a population-level strategy for performing separate but linked computations. PMID:27807345

  20. Reorganization of a granular medium around a localized transformation.

    PubMed

    Merceron, Aymeric; Sauret, Alban; Jop, Pierre

    2016-06-01

    Physical and chemical transformation processes in reactive granular media involve the reorganization of the structure. In this paper, we study experimentally the rearrangements of a two-dimensional (2D) granular packing undergoing a localized transformation. We track the position and evolution of all the disks that constitute the granular packing when either a large intruder shrinks in size or is pulled out of the granular structure. In the two situations the displacements at long time are similar to 2D quasistatic silo flows whereas the short-time dynamic is heterogeneous in both space and time. We observe an avalanchelike behavior with power-law distributed events uncorrelated in time. In addition, the instantaneous evolutions of the local solid fraction exhibit self-similar distributions. The averages and the standard deviations of the solid fraction variations can be rescaled, suggesting a single mechanism of rearrangement.

  1. Reorganization of a granular medium around a localized transformation

    NASA Astrophysics Data System (ADS)

    Merceron, Aymeric; Sauret, Alban; Jop, Pierre

    2016-06-01

    Physical and chemical transformation processes in reactive granular media involve the reorganization of the structure. In this paper, we study experimentally the rearrangements of a two-dimensional (2D) granular packing undergoing a localized transformation. We track the position and evolution of all the disks that constitute the granular packing when either a large intruder shrinks in size or is pulled out of the granular structure. In the two situations the displacements at long time are similar to 2D quasistatic silo flows whereas the short-time dynamic is heterogeneous in both space and time. We observe an avalanchelike behavior with power-law distributed events uncorrelated in time. In addition, the instantaneous evolutions of the local solid fraction exhibit self-similar distributions. The averages and the standard deviations of the solid fraction variations can be rescaled, suggesting a single mechanism of rearrangement.

  2. Exposure therapy triggers lasting reorganization of neural fear processing.

    PubMed

    Hauner, Katherina K; Mineka, Susan; Voss, Joel L; Paller, Ken A

    2012-06-05

    A single session of exposure therapy can eliminate recalcitrant and disabling fear of phobogenic objects or situations. We studied neural mechanisms of this remarkable outcome by monitoring changes in brain activity as a result of successful 2-h treatment. Before treatment, phobogenic images excited activity in a network of regions, including amygdala, insula, and cingulate cortex, relative to neutral images. Successful therapy dampened responsiveness in this fear-sensitive network while concomitantly heightening prefrontal involvement. Six months later, dampened fear-network activity persisted but without prefrontal engagement. Additionally, individual differences in the magnitude of visual cortex activations recorded shortly after therapy predicted therapeutic outcomes 6 mo later, which involved persistently diminished visual responsiveness to phobogenic images. Successful therapy thus entailed stable reorganization of neural responses to initially feared stimuli. These effects were linked to fear-extinction mechanisms identified in animal models, thus opening new opportunities for the treatment and prevention of debilitating anxiety disorders.

  3. Thalamic Reorganization in Chronic Patients With Intracerebral Hemorrhage

    PubMed Central

    Jang, Sung Ho; Chang, Chul Hoon; Kim, Seong Ho; Jung, Young Jin; Hong, Ji Heon

    2015-01-01

    Abstract The aim of this study was to investigate changes of synaptic area of the spinothalamic tract and its thalamocortical pathway (STT) in the thalamus in chronic patients with putaminal hemorrhage. Twenty four patients with a lesion in the ventral posterior lateral nucleus (VPL) of the thalamus following putaminal hemorrhage were recruited for this study. The subscale for tactile sensation of the Nottingham Sensory Assessment (NSA) was used for the determination of somatosensory function. Diffusion tensor tractography of the STT was reconstructed using the Functional Magnetic Resonance Imaging of the Brain Software Library. We classified patients according to 2 groups: the VPL group, patients whose STTs were synapsed in the VPL; and the non-VPL group, patients whose STTs were synapsed in other thalamic areas, except for the VPL. Thirteen patients belonged to the VPL group, and 8 patients belonged to the non-VPL group. Three patients were excluded from grouping due to interrupted integrity of the STTs. The tactile sensation score of the NSA in the non-VPL group (10.50 ± 0.93) was significantly decreased compared with that of the VPL group (19.45 ± 1.33) (P < 0.05). We found that 2 types of patient had recovered via the VPL area or other areas of the STT. It appears that patients who showed shifting of the thalamic synaptic area of the STT might have recovered by the process of thalamic reorganization following thalamic injury. In addition, thalamic reorganization appears to be related to poorer somatosensory outcome. PMID:26313781

  4. Correlation between cerebral reorganization and motor recovery after subcortical infarcts.

    PubMed

    Loubinoux, Isabelle; Carel, Christophe; Pariente, Jérémie; Dechaumont, Sophie; Albucher, Jean-François; Marque, Philippe; Manelfe, Claude; Chollet, François

    2003-12-01

    Our objective was to investigate correlations between clinical motor scores and cerebral sensorimotor activation to demonstrate that this reorganization is the neural substratum of motor recovery. Correlation analyses identified reorganization processes shared by all patients. Nine patients with first-time corticospinal tract lacuna were clinically evaluated using the NIH stroke scale, the motricity index, and the Barthel index. Patients were strictly selected for pure motor deficits. They underwent a first fMRI session (E1) 11 days after stroke, and then a second (E2) 4 weeks later. The task used was a calibrated repetitive passive flexion/extension of the paretic wrist. The control task was rest. Six healthy subjects followed the same protocol. Patients were also clinically evaluated 4 and 12 months after stroke. All patients improved significantly between E1 and E2. For E1 and E2, the ipsilesional primary sensorimotor and premotor cortex, supplementary motor area (SMA), and bilateral Broadmann area (BA) 40 were activated. Activation intensity was greater at the second examination except in the ipsilesional superior BA 40. Magnitude of activation was lower than that of controls except for well-recovered patients. E1 clinical hand motor score and E1 cerebral activation correlated in the SMA proper and inferior ipsilesional BA 40. Thus, we demonstrated early functionality of the sensorimotor system. The whole sensorimotor network activation correlated with motor status at E2, indicating a recovery of its function when activated. Moreover, the activation pattern in the acute phase (E1) had a predictive value: early recruitment and high activation of the SMA and inferior BA 40 were correlated with a faster or better motor recovery. On the contrary, activation of the contralesional hemisphere (prefrontal cortex and BA 39-40) and of the posterior cingulate/precuneus (BA 7-31) predicted a slower recovery.

  5. Large-Scale Functional Brain Network Reorganization During Taoist Meditation.

    PubMed

    Jao, Tun; Li, Chia-Wei; Vértes, Petra E; Wu, Changwei Wesley; Achard, Sophie; Hsieh, Chao-Hsien; Liou, Chien-Hui; Chen, Jyh-Horng; Bullmore, Edward T

    2016-02-01

    Meditation induces a distinct and reversible mental state that provides insights into brain correlates of consciousness. We explored brain network changes related to meditation by graph theoretical analysis of resting-state functional magnetic resonance imaging data. Eighteen Taoist meditators with varying levels of expertise were scanned using a within-subjects counterbalanced design during resting and meditation states. State-related differences in network topology were measured globally and at the level of individual nodes and edges. Although measures of global network topology, such as small-worldness, were unchanged, meditation was characterized by an extensive and expertise-dependent reorganization of the hubs (highly connected nodes) and edges (functional connections). Areas of sensory cortex, especially the bilateral primary visual and auditory cortices, and the bilateral temporopolar areas, which had the highest degree (or connectivity) during the resting state, showed the biggest decrease during meditation. Conversely, bilateral thalamus and components of the default mode network, mainly the bilateral precuneus and posterior cingulate cortex, had low degree in the resting state but increased degree during meditation. Additionally, these changes in nodal degree were accompanied by reorganization of anatomical orientation of the edges. During meditation, long-distance longitudinal (antero-posterior) edges increased proportionally, whereas orthogonal long-distance transverse (right-left) edges connecting bilaterally homologous cortices decreased. Our findings suggest that transient changes in consciousness associated with meditation introduce convergent changes in the topological and spatial properties of brain functional networks, and the anatomical pattern of integration might be as important as the global level of integration when considering the network basis for human consciousness.

  6. Multibeam investigation of the active North Atlantic plate boundary reorganization tip

    NASA Astrophysics Data System (ADS)

    Hey, Richard; Martinez, Fernando; Höskuldsson, Ármann; Eason, Deborah E.; Sleeper, Jonathan; Thordarson, Sigvaldi; Benediktsdóttir, Ásdís; Merkuryev, Sergey

    2016-02-01

    The previous orthogonal ridge/transform staircase geometry south of Iceland is being progressively changed to the present continuous oblique Reykjanes Ridge spreading geometry as North America-Eurasia transform faults are successively eliminated from north to south. This reorganization is commonly interpreted as a thermal phenomenon, caused by warmer Iceland plume mantle progressively interacting with the ridge, although other diachronous seafloor spreading reorganizations are thought to result from tectonic rift propagation. New marine geophysical data covering our reinterpretation of the reorganization tip near 57°N show successive transform eliminations at a propagation velocity of ∼110 km/Myr, ten times the spreading half rate, followed by abrupt reorganization slowing at the Modred transform as it was converted to a migrating non-transform offset. Neither the simple thermal model nor the simple propagating rift model appears adequate to explain the complicated plate boundary reorganization process.

  7. Feelings of betrayal by the United Nations High Commissioner for Refugees and emotionally distressed Sudanese refugees in Cairo.

    PubMed

    Meffert, Susan M; Musalo, Karen; Abdo, Akram Osman; Alla, Omayma Ahmed Abd; Elmakki, Yasir Omer Mustafa; Omer, Afrah Abdelrahim; Yousif, Sahar; Metzler, Thomas J; Marmar, Charles R

    2010-01-01

    Thousands of Sudanese refugees have fled to Cairo, Egypt in the wake of Sudanese civil conflicts. Sudanese refugees were evaluated with respect to symptoms of depression, post-traumatic stress disorder (PTSD) and social stress. Four respondents (22%) indicated that their interactions with the United Nations High Commissioner for Refugees (UNHCR) in Cairo, Egypt were the worst experiences since war-related atrocities. Fourteen participants (63.6%) felt 'extremely' betrayed by the UNHCR on a four point scale. Greater feelings of betrayal by the UNHCR were associated with greater avoidance and arousal symptoms of PTSD, symptoms of depression and trait anger. This is the first study of which we are aware that examines the relationship between sense of betrayal by the UNHCR and symptoms of PTSD, depression and anger among asylum seekers.

  8. 77 FR 48959 - Foreign-Trade Zone 133-Quad-Cities, Iowa/Illinois Application for Reorganization Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-15

    ... Reorganization Under Alternative Site Framework An application has been submitted to the Foreign-Trade Zones (FTZ... reorganize the zone under the alternative site framework (ASF) adopted by the Board (15 CFR 400.2(c))....

  9. 76 FR 76934 - Foreign-Trade Zone 89-Las Vegas, NV; Application for Reorganization and Expansion Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ... Reorganization and Expansion Under Alternative Site Framework An application has been submitted to the Foreign... authority to reorganize and expand the zone under the alternative site framework (ASF) adopted by the...

  10. 26 CFR 1.6046-3 - Returns as to formation or reorganization of foreign corporations prior to September 15, 1960.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 13 2012-04-01 2012-04-01 false Returns as to formation or reorganization of...) Information Returns § 1.6046-3 Returns as to formation or reorganization of foreign corporations prior to... advises in, or with respect to, the formation, organization, or reorganization of any foreign...

  11. 26 CFR 1.6046-3 - Returns as to formation or reorganization of foreign corporations prior to September 15, 1960.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 13 2013-04-01 2013-04-01 false Returns as to formation or reorganization of...) Information Returns § 1.6046-3 Returns as to formation or reorganization of foreign corporations prior to... advises in, or with respect to, the formation, organization, or reorganization of any foreign...

  12. 26 CFR 1.6046-3 - Returns as to formation or reorganization of foreign corporations prior to September 15, 1960.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Returns as to formation or reorganization of... Returns § 1.6046-3 Returns as to formation or reorganization of foreign corporations prior to September 15... with respect to, the formation, organization, or reorganization of any foreign corporation shall...

  13. 7 CFR 4279.137 - Financial statements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... § 4279.137 Financial statements. (a) The lender will determine the type and frequency of submission of financial statements by the borrower. At a minimum, annual financial statements prepared by an accountant in... 7 Agriculture 15 2010-01-01 2010-01-01 false Financial statements. 4279.137 Section...

  14. It's Time to Implement GASB Statement 54

    ERIC Educational Resources Information Center

    Heinfeld, Gary; Nuehring, Bert

    2012-01-01

    In February 2009, the Governmental Accounting Standards Board (GASB) issued Statement No. 54, "Find Balance Reporting and Governmental Fund Type Definitions." This statement changes how a fund balance is classified on the face of the government fund financial statements and refines the definitions for government fund types. The statement's…

  15. 7 CFR 1218.51 - Financial statements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Financial statements. 1218.51 Section 1218.51... § 1218.51 Financial statements. (a) As requested by the Secretary, the Council shall prepare and submit financial statements to the Secretary on a periodic basis. Each such financial statement shall include,...

  16. 29 CFR 99.310 - Financial statements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Financial statements. 99.310 Section 99.310 Labor Office of....310 Financial statements. (a) Financial statements. The auditee shall prepare financial statements that reflect its financial position, results of operations or changes in net assets, and,...

  17. 38 CFR 41.310 - Financial statements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Financial statements. 41...) AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditees § 41.310 Financial statements. (a) Financial statements. The auditee shall prepare financial statements that reflect its...

  18. 7 CFR 4279.137 - Financial statements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Financial statements. 4279.137 Section 4279.137... § 4279.137 Financial statements. (a) The lender will determine the type and frequency of submission of financial statements by the borrower. At a minimum, annual financial statements prepared by an accountant...

  19. 38 CFR 41.310 - Financial statements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Financial statements. 41...) AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditees § 41.310 Financial statements. (a) Financial statements. The auditee shall prepare financial statements that reflect its...

  20. 7 CFR 1206.41 - Financial statements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Financial statements. 1206.41 Section 1206.41... Financial statements. (a) As requested by the Department, the Board shall prepare and submit financial statements to the Department on a periodic basis. Each such financial statement shall include, but not...

  1. 7 CFR 1206.41 - Financial statements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Financial statements. 1206.41 Section 1206.41... Financial statements. (a) As requested by the Department, the Board shall prepare and submit financial statements to the Department on a periodic basis. Each such financial statement shall include, but not...

  2. 29 CFR 99.310 - Financial statements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Financial statements. 99.310 Section 99.310 Labor Office of....310 Financial statements. (a) Financial statements. The auditee shall prepare financial statements that reflect its financial position, results of operations or changes in net assets, and,...

  3. 7 CFR 1218.51 - Financial statements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Financial statements. 1218.51 Section 1218.51... § 1218.51 Financial statements. (a) As requested by the Secretary, the Council shall prepare and submit financial statements to the Secretary on a periodic basis. Each such financial statement shall include,...

  4. 38 CFR 41.310 - Financial statements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Financial statements. 41...) AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditees § 41.310 Financial statements. (a) Financial statements. The auditee shall prepare financial statements that reflect its...

  5. 7 CFR 1206.41 - Financial statements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Financial statements. 1206.41 Section 1206.41... Financial statements. (a) As requested by the Department, the Board shall prepare and submit financial statements to the Department on a periodic basis. Each such financial statement shall include, but not...

  6. 7 CFR 4279.137 - Financial statements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Financial statements. 4279.137 Section 4279.137... § 4279.137 Financial statements. (a) The lender will determine the type and frequency of submission of financial statements by the borrower. At a minimum, annual financial statements prepared by an accountant...

  7. 7 CFR 1218.51 - Financial statements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Financial statements. 1218.51 Section 1218.51... § 1218.51 Financial statements. (a) As requested by the Secretary, the Council shall prepare and submit financial statements to the Secretary on a periodic basis. Each such financial statement shall include,...

  8. Porous silicon reorganization: Influence on the structure, surface roughness and strain

    NASA Astrophysics Data System (ADS)

    Milenkovic, N.; Drießen, M.; Weiss, C.; Janz, S.

    2015-12-01

    Porous silicon and epitaxial thickening is a lift-off approach for silicon foil fabrication to avoid kerf losses and produce foils with thicknesses less than 50 μm. The crystal quality of the epitaxial silicon film strongly depends on the porous silicon template, which can be adapted through a reorganization process prior to epitaxy. In this work, we investigated the influence of reorganization on the structure of etched porous silicon layers. The reorganization processes were carried out in a quasi-inline Atmospheric Pressure Chemical Vapor Deposition reactor. Variations on the temperatures and process durations for the reorganization step were examined. The cross-sections showed that porous silicon requires temperatures of approximately 1150 °C to produce an excellent template for epitaxy. Atomic Force Microscopy measurements on the samples annealed at different temperatures showed the evolution of the pores from as-etched to a closed surface. These measurements confirm that the surface is not yet closed after 30 min of reorganization at 1000 °C. Different durations of the reorganization step at a fixed temperature of 1150 °C all lead to a closed surface with a comparable roughness of less than 0.5 nm. X-ray diffraction measurements show a change in the strain in the porous layer from tensile to compressive when the reorganization temperature is increased from 800 °C to 1150 °C. A longer reorganization at a fixed temperature of 1150 °C leads to a reduction in the strain without reducing the quality of the surface roughness. Defect density measurements on silicon layers deposited on those templates confirm an improvement of the template for longer reorganization times. This study shows that our porous silicon templates achieve lower surface roughness and strain values than those reported in other publications.

  9. Cortical reorganization after macroreplantation at the upper extremity: a magnetoencephalographic study.

    PubMed

    Blume, Kathrin R; Dietrich, Caroline; Huonker, Ralph; Götz, Theresa; Sens, Elisabeth; Friedel, Reinhard; Hofmann, Gunther O; Miltner, Wolfgang H R; Weiss, Thomas

    2014-03-01

    With the development of microsurgical techniques, replantation has become a feasible alternative to stump treatment after the amputation of an extremity. It is known that amputation often induces phantom limb pain and cortical reorganization within the corresponding somatosensory areas. However, whether replantation reduces the risk of comparable persisting pain phenomena as well as reorganization of the primary somatosensory cortex is still widely unknown. Therefore, the present study aimed to investigate the potential development of persistent pain and cortical reorganization of the hand and lip areas within the sensory cortex by means of magnetoencephalographic dipole analyses after replantation of a traumatically amputated upper limb proximal to the radiocarpal joint. Cortical reorganization was investigated in 13 patients with limb replantation using air puff stimulation of the phalanges of both thumbs and both corners of the lower lip. Displacement of the centre of gravity of lip and thumb representations and increased cortical activity were found in the limb and face areas of the primary somatosensory cortex contralateral to the replanted arm when compared to the ipsilateral hemisphere. Thus, cortical reorganization in the primary somatosensory cortex also occurs after replantation of the upper extremity. Patients' reports of pain in the replanted body part were negatively correlated with the amount of cortical reorganization, i.e. the more pain the patients reported, the less reorganization of the subjects' hand representation within the primary somatosensory cortex was observed. Longitudinal studies in patients after macroreplantation are necessary to assess whether the observed reorganization in the primary somatosensory cortex is a result of changes within the representation of the replanted arm and/or neighbouring representations and to assess the relationship between the development of persistent pain and reorganization.

  10. Environmental Impact Statement Filing Guidance

    EPA Pesticide Factsheets

    Describes how to submit an environmental impact statement through the e-NEPA electronic submission system. Describes how EPA submits a notice of availability in to the Federal Register and how the comment time period if set forth.

  11. Pajaro Dunes Conference Draft Statement.

    ERIC Educational Resources Information Center

    Journal of College and University Law, 1982

    1982-01-01

    A statement of concerns and needs in the relationship between universities and industry for biomedical research addresses the issues of research agreements and their terms, patent licensing, university and faculty roles, and establishment of policy and procedures. (MSE)

  12. Statement on intrauterine devices.

    PubMed

    1981-12-01

    These policy statements and guidelines from the International Planned Parenthood Federation's (IPPF) International Medical Advisory Panel (IMAP) concern IUDs. The following contraindications to IUD use are recognized: 1) pelvic inflaminatory disease, 2) known or suspected pregnancy, 3) history of previous ectopic pregnancy, 4) gynecological bleeding disorders, 5) suspected malignancy of the genital tract, 6) congenital uterine abnormalities or fibroids distorting the cavity, and 7) anemia, blood coagulation, severe cervical stenosis, copper allergy, Wilson's disease, and others. Generalities regarding appropriate IUDs are: 1) non-medicated devices (e.g. Lippes Loop) are studied for women who may not return for regular check-ups, 2) smaller medicated devices usually cause less menstrual blood loss than the non-medicated devices, 3) smaller devices are better for a smaller uterus and larger devices for the larger uterus, and 4) when a smaller device is expelled it is advisable to try a larger one and vice versa. Dalkon Shields should not be used by the IPPF system and all women using them should have the device removed. Correct insertion of IUDs is important and should be done by properly trained personnel. The timing of insertion is best during the menstrual period. Withdrawal of the applicator while leaving the device in place is the recommended insertion technique. Sterilization of IUDs should follow instructions on bulk-packaged IUDs. Complications include perforation, bleeding and pain, infection, and ectopic pregnancy. IUD removal should be done during menstruation. Good clinical management and follow-up care are recommended.

  13. Light signaling controls nuclear architecture reorganization during seedling establishment.

    PubMed

    Bourbousse, Clara; Mestiri, Imen; Zabulon, Gerald; Bourge, Mickaël; Formiggini, Fabio; Koini, Maria A; Brown, Spencer C; Fransz, Paul; Bowler, Chris; Barneche, Fredy

    2015-05-26

    The spatial organization of chromatin can be subject to extensive remodeling in plant somatic cells in response to developmental and environmental signals. However, the mechanisms controlling these dynamic changes and their functional impact on nuclear activity are poorly understood. Here, we determined that light perception triggers a switch between two different nuclear architectural schemes during Arabidopsis postembryonic development. Whereas progressive nucleus expansion and heterochromatin rearrangements in cotyledon cells are achieved similarly under light and dark conditions during germination, the later steps that lead to mature nuclear phenotypes are intimately associated with the photomorphogenic transition in an organ-specific manner. The light signaling integrators DE-ETIOLATED 1 and CONSTITUTIVE PHOTOMORPHOGENIC 1 maintain heterochromatin in a decondensed state in etiolated cotyledons. In contrast, under light conditions cryptochrome-mediated photoperception releases nuclear expansion and heterochromatin compaction within conspicuous chromocenters. For all tested loci, chromatin condensation during photomorphogenesis does not detectably rely on DNA methylation-based processes. Notwithstanding, the efficiency of transcriptional gene silencing may be impacted during the transition, as based on the reactivation of transposable element-driven reporter genes. Finally, we report that global engagement of RNA polymerase II in transcription is highly increased under light conditions, suggesting that cotyledon photomorphogenesis involves a transition from globally quiescent to more active transcriptional states. Given these findings, we propose that light-triggered changes in nuclear architecture underlie interplays between heterochromatin reorganization and transcriptional reprogramming associated with the establishment of photosynthesis.

  14. Supervillin Reorganizes the Actin Cytoskeleton and Increases Invadopodial Efficiency

    PubMed Central

    Crowley, Jessica L.; Smith, Tara C.; Fang, Zhiyou; Takizawa, Norio

    2009-01-01

    Tumor cells use actin-rich protrusions called invadopodia to degrade extracellular matrix (ECM) and invade tissues; related structures, termed podosomes, are sites of dynamic ECM interaction. We show here that supervillin (SV), a peripheral membrane protein that binds F-actin and myosin II, reorganizes the actin cytoskeleton and potentiates invadopodial function. Overexpressed SV induces redistribution of lamellipodial cortactin and lamellipodin/RAPH1/PREL1 away from the cell periphery to internal sites and concomitantly increases the numbers of F-actin punctae. Most punctae are highly dynamic and colocalize with the podosome/invadopodial proteins, cortactin, Tks5, and cdc42. Cortactin binds SV sequences in vitro and contributes to the formation of enhanced green fluorescent protein (EGFP)-SV induced punctae. SV localizes to the cores of Src-generated podosomes in COS-7 cells and with invadopodia in MDA-MB-231 cells. EGFP-SV overexpression increases average numbers of ECM holes per cell; RNA interference-mediated knockdown of SV decreases these numbers. Although SV knockdown alone has no effect, simultaneous down-regulation of SV and the closely related protein gelsolin reduces invasion through ECM. Together, our results show that SV is a component of podosomes and invadopodia and that SV plays a role in invadopodial function, perhaps as a mediator of cortactin localization, activation state, and/or dynamics of metalloproteinases at the ventral cell surface. PMID:19109420

  15. Integrated molecular mechanism directing nucleosome reorganization by human FACT.

    PubMed

    Tsunaka, Yasuo; Fujiwara, Yoshie; Oyama, Takuji; Hirose, Susumu; Morikawa, Kosuke

    2016-03-15

    Facilitates chromatin transcription (FACT) plays essential roles in chromatin remodeling during DNA transcription, replication, and repair. Our structural and biochemical studies of human FACT-histone interactions present precise views of nucleosome reorganization, conducted by the FACT-SPT16 (suppressor of Ty 16) Mid domain and its adjacent acidic AID segment. AID accesses the H2B N-terminal basic region exposed by partial unwrapping of the nucleosomal DNA, thereby triggering the invasion of FACT into the nucleosome. The crystal structure of the Mid domain complexed with an H3-H4 tetramer exhibits two separate contact sites; the Mid domain forms a novel intermolecular β structure with H4. At the other site, the Mid-H2A steric collision on the H2A-docking surface of the H3-H4 tetramer within the nucleosome induces H2A-H2B displacement. This integrated mechanism results in disrupting the H3 αN helix, which is essential for retaining the nucleosomal DNA ends, and hence facilitates DNA stripping from histone.

  16. Behavioral Consequences and Cortical Reorganization in Homonymous Hemianopia

    PubMed Central

    Chokron, Sylvie; Perez, Céline; Peyrin, Carole

    2016-01-01

    The most common visual defect to follow a lesion of the retrochiasmal pathways is homonymous hemianopia (HH), whereby, in each eye, patients are blind to the contralesional visual field. From a behavioral perspective, in addition to exhibiting a severe deficit in their contralesional visual field, hemianopic patients can also present implicit residual capacities, now usually referred to collectively as blindsight. It was recently demonstrated that HH patients can also suffer from a subtle deficit in their ipsilesional visual field, called sightblindness (the reverse case of blindsight). Furthermore, the nature of the visual deficit in the contralesional and ipsilesional visual fields, as well as the pattern of functional reorganization in the occipital lobe of HH patients after stroke, all appear to depend on the lesion side. In addition to their contralesional and ipsilesional visual deficits, and to their residual capacities, HH patients can also experience visual hallucinations in their blind field, the physiopathological mechanisms of which remain poorly understood. Herein we review blindsight in terms of its better-known aspects as well as its less-studied clinical signs such as sightblindness, hemispheric specialization and visual hallucinations. We also discuss the implications of recent experimental findings for rehabilitation of visual field defects in hemianopic patients. PMID:27445717

  17. Mechanism of filopodia initiation by reorganization of a dendritic network

    PubMed Central

    Svitkina, Tatyana M.; Bulanova, Elena A.; Chaga, Oleg Y.; Vignjevic, Danijela M.; Kojima, Shin-ichiro; Vasiliev, Jury M.; Borisy, Gary G.

    2003-01-01

    Afilopodium protrudes by elongation of bundled actin filaments in its core. However, the mechanism of filopodia initiation remains unknown. Using live-cell imaging with GFP-tagged proteins and correlative electron microscopy, we performed a kinetic-structural analysis of filopodial initiation in B16F1 melanoma cells. Filopodial bundles arose not by a specific nucleation event, but by reorganization of the lamellipodial dendritic network analogous to fusion of established filopodia but occurring at the level of individual filaments. Subsets of independently nucleated lamellipodial filaments elongated and gradually associated with each other at their barbed ends, leading to formation of cone-shaped structures that we term Λ-precursors. An early marker of initiation was the gradual coalescence of GFP-vasodilator-stimulated phosphoprotein (GFP-VASP) fluorescence at the leading edge into discrete foci. The GFP-VASP foci were associated with Λ-precursors, whereas Arp2/3 was not. Subsequent recruitment of fascin to the clustered barbed ends of Λ-precursors initiated filament bundling and completed formation of the nascent filopodium. We propose a convergent elongation model of filopodia initiation, stipulating that filaments within the lamellipodial dendritic network acquire privileged status by binding a set of molecules (including VASP) to their barbed ends, which protect them from capping and mediate association of barbed ends with each other. PMID:12566431

  18. Mechanism of filopodia initiation by reorganization of a dendritic network.

    PubMed

    Svitkina, Tatyana M; Bulanova, Elena A; Chaga, Oleg Y; Vignjevic, Danijela M; Kojima, Shin-ichiro; Vasiliev, Jury M; Borisy, Gary G

    2003-02-03

    Afilopodium protrudes by elongation of bundled actin filaments in its core. However, the mechanism of filopodia initiation remains unknown. Using live-cell imaging with GFP-tagged proteins and correlative electron microscopy, we performed a kinetic-structural analysis of filopodial initiation in B16F1 melanoma cells. Filopodial bundles arose not by a specific nucleation event, but by reorganization of the lamellipodial dendritic network analogous to fusion of established filopodia but occurring at the level of individual filaments. Subsets of independently nucleated lamellipodial filaments elongated and gradually associated with each other at their barbed ends, leading to formation of cone-shaped structures that we term Lambda-precursors. An early marker of initiation was the gradual coalescence of GFP-vasodilator-stimulated phosphoprotein (GFP-VASP) fluorescence at the leading edge into discrete foci. The GFP-VASP foci were associated with Lambda-precursors, whereas Arp2/3 was not. Subsequent recruitment of fascin to the clustered barbed ends of Lambda-precursors initiated filament bundling and completed formation of the nascent filopodium. We propose a convergent elongation model of filopodia initiation, stipulating that filaments within the lamellipodial dendritic network acquire privileged status by binding a set of molecules (including VASP) to their barbed ends, which protect them from capping and mediate association of barbed ends with each other.

  19. An improved algorithm of fiber tractography demonstrates postischemic cerebral reorganization

    NASA Astrophysics Data System (ADS)

    Liu, Xiao-dong; Lu, Jie; Yao, Li; Li, Kun-cheng; Zhao, Xiao-jie

    2008-03-01

    In vivo white matter tractography by diffusion tensor imaging (DTI) accurately represents the organizational architecture of white matter in the vicinity of brain lesions and especially ischemic brain. In this study, we suggested an improved fiber tracking algorithm based on TEND, called TENDAS, for tensor deflection with adaptive stepping, which had been introduced a stepping framework for interpreting the algorithm behavior as a function of the tensor shape (linear-shaped or not) and tract history. The propagation direction at each step was given by the deflection vector. TENDAS tractography was used to examine a 17-year-old recovery patient with congenital right hemisphere artery stenosis combining with fMRI. Meaningless picture location was used as spatial working memory task in this study. We detected the shifted functional localization to the contralateral homotypic cortex and more prominent and extensive left-sided parietal and medial frontal cortical activations which were used directly as seed mask for tractography for the reconstruction of individual spatial parietal pathways. Comparing with the TEND algorithms, TENDAS shows smoother and less sharp bending characterization of white matter architecture of the parietal cortex. The results of this preliminary study were twofold. First, TENDAS may provide more adaptability and accuracy in reconstructing certain anatomical features, whereas it is very difficult to verify tractography maps of white matter connectivity in the living human brain. Second, our study indicates that combination of TENDAS and fMRI provide a unique image of functional cortical reorganization and structural modifications of postischemic spatial working memory.

  20. Integrated molecular mechanism directing nucleosome reorganization by human FACT

    PubMed Central

    Tsunaka, Yasuo; Fujiwara, Yoshie; Oyama, Takuji; Hirose, Susumu; Morikawa, Kosuke

    2016-01-01

    Facilitates chromatin transcription (FACT) plays essential roles in chromatin remodeling during DNA transcription, replication, and repair. Our structural and biochemical studies of human FACT–histone interactions present precise views of nucleosome reorganization, conducted by the FACT-SPT16 (suppressor of Ty 16) Mid domain and its adjacent acidic AID segment. AID accesses the H2B N-terminal basic region exposed by partial unwrapping of the nucleosomal DNA, thereby triggering the invasion of FACT into the nucleosome. The crystal structure of the Mid domain complexed with an H3–H4 tetramer exhibits two separate contact sites; the Mid domain forms a novel intermolecular β structure with H4. At the other site, the Mid–H2A steric collision on the H2A-docking surface of the H3–H4 tetramer within the nucleosome induces H2A–H2B displacement. This integrated mechanism results in disrupting the H3 αN helix, which is essential for retaining the nucleosomal DNA ends, and hence facilitates DNA stripping from histone. PMID:26966247

  1. Reorganization of the North Atlantic Oscillation during early Holocene deglaciation

    NASA Astrophysics Data System (ADS)

    Wassenburg, Jasper A.; Dietrich, Stephan; Fietzke, Jan; Fohlmeister, Jens; Jochum, Klaus Peter; Scholz, Denis; Richter, Detlev K.; Sabaoui, Abdellah; Spötl, Christoph; Lohmann, Gerrit; Andreae, Meinrat O.; Immenhauser, Adrian

    2016-08-01

    The North Atlantic Oscillation is the dominant atmospheric pressure mode in the North Atlantic region and affects winter temperature and precipitation in the Mediterranean, northwest Europe, Greenland, and Asia. The index that describes the sea-level pressure difference between Iceland and the Azores is correlated with a dipole precipitation pattern over northwest Europe and northwest Africa. How the North Atlantic Oscillation will develop as the Greenland ice sheet melts is unclear. A potential past analogue is the early Holocene, during which melting ice sheets around the North Atlantic freshened surface waters, affecting the strength of the meridional overturning circulation. Here we present a Holocene rainfall record from northwest Africa based on speleothem δ18O and compare it against a speleothem-based rainfall record from Europe. The two records are positively correlated during the early Holocene, followed by a shift to an anti-correlation, similar to the modern record, during the mid-Holocene. On the basis of our simulations with an Earth system model, we suggest the shift to the anti-correlation reflects a large-scale atmospheric and oceanic reorganization in response to the demise of the Laurentide ice sheet and a strong reduction of meltwater flux to the North Atlantic, pointing to a potential sensitivity of the North Atlantic Oscillation to the melting of ice sheets.

  2. Global Reorganization of the Nuclear Landscape in Senescent Cells

    PubMed Central

    Chandra, Tamir; Ewels, Philip Andrew; Schoenfelder, Stefan; Furlan-Magaril, Mayra; Wingett, Steven William; Kirschner, Kristina; Thuret, Jean-Yves; Andrews, Simon; Fraser, Peter; Reik, Wolf

    2015-01-01

    Summary Cellular senescence has been implicated in tumor suppression, development, and aging and is accompanied by large-scale chromatin rearrangements, forming senescence-associated heterochromatic foci (SAHF). However, how the chromatin is reorganized during SAHF formation is poorly understood. Furthermore, heterochromatin formation in senescence appears to contrast with loss of heterochromatin in Hutchinson-Gilford progeria. We mapped architectural changes in genome organization in cellular senescence using Hi-C. Unexpectedly, we find a dramatic sequence- and lamin-dependent loss of local interactions in heterochromatin. This change in local connectivity resolves the paradox of opposing chromatin changes in senescence and progeria. In addition, we observe a senescence-specific spatial clustering of heterochromatic regions, suggesting a unique second step required for SAHF formation. Comparison of embryonic stem cells (ESCs), somatic cells, and senescent cells shows a unidirectional loss in local chromatin connectivity, suggesting that senescence is an endpoint of the continuous nuclear remodelling process during differentiation. PMID:25640177

  3. Intermediate filament reorganization dynamically influences cancer cell alignment and migration

    PubMed Central

    Holle, Andrew W.; Kalafat, Melih; Ramos, Adria Sales; Seufferlein, Thomas; Kemkemer, Ralf; Spatz, Joachim P.

    2017-01-01

    The interactions between a cancer cell and its extracellular matrix (ECM) have been the focus of an increasing amount of investigation. The role of the intermediate filament keratin in cancer has also been coming into focus of late, but more research is needed to understand how this piece fits in the puzzle of cytoskeleton-mediated invasion and metastasis. In Panc-1 invasive pancreatic cancer cells, keratin phosphorylation in conjunction with actin inhibition was found to be sufficient to reduce cell area below either treatment alone. We then analyzed intersecting keratin and actin fibers in the cytoskeleton of cyclically stretched cells and found no directional correlation. The role of keratin organization in Panc-1 cellular morphological adaptation and directed migration was then analyzed by culturing cells on cyclically stretched polydimethylsiloxane (PDMS) substrates, nanoscale grates, and rigid pillars. In general, the reorganization of the keratin cytoskeleton allows the cell to become more ‘mobile’- exhibiting faster and more directed migration and orientation in response to external stimuli. By combining keratin network perturbation with a variety of physical ECM signals, we demonstrate the interconnected nature of the architecture inside the cell and the scaffolding outside of it, and highlight the key elements facilitating cancer cell-ECM interactions. PMID:28338091

  4. Stimulus Dependent Dynamic Reorganization of the Human Face Processing Network.

    PubMed

    Rosenthal, Gideon; Sporns, Olaf; Avidan, Galia

    2016-09-12

    Using the "face inversion effect", a hallmark of face perception, we examined network mechanisms supporting face representation by tracking functional magnetic resonance imaging (fMRI) stimulus-dependent dynamic functional connectivity within and between brain networks associated with the processing of upright and inverted faces. We developed a novel approach adapting the general linear model (GLM) framework classically used for univariate fMRI analysis to capture stimulus-dependent fMRI dynamic connectivity of the face network. We show that under the face inversion manipulation, the face and non-face networks have complementary roles that are evident in their stimulus-dependent dynamic connectivity patterns as assessed by network decomposition into components or communities. Moreover, we show that connectivity patterns are associated with the behavioral face inversion effect. Thus, we establish "a network-level signature" of the face inversion effect and demonstrate how a simple physical transformation of the face stimulus induces a dramatic functional reorganization across related brain networks. Finally, we suggest that the dynamic GLM network analysis approach, developed here for the face network, provides a general framework for modeling the dynamics of blocked stimulus-dependent connectivity experimental designs and hence can be applied to a host of neuroimaging studies.

  5. Reorganization of human motor cortex after hand replantation.

    PubMed

    Röricht, S; Machetanz, J; Irlbacher, K; Niehaus, L; Biemer, E; Meyer, B U

    2001-08-01

    In 10 patients, reorganizational changes of the motor cortex contralateral to a replanted hand (MCreplant) were studied one to 14 years after complete traumatic amputation and consecutive successful replantation of the hand. The organizational state of MCreplant was assessed for the deafferentated and peripherally deefferentated hand-associated motor cortex and the adjacent motor representation of the proximal arm. For this, response maps were established for the first dorsal interosseus and biceps brachii muscle using focal transcranial magnetic stimulation (TMS) on a skull surface grid. Characteristics of the maps were center of gravity (COG), number of effective stimulation sites, amplitude sum, and amplitudes and response threshold at the optimal stimulation point. The COG is defined by the spatial distribution of response amplitudes on the map and lies over the cortex region with the most excitable corticospinal neurones supplying the recorded muscle. The COG of the biceps map in MCreplant was shifted laterally by 9.8 +/- 3.6 mm (range 5.0-15.7 mm). The extension of the biceps map in MCreplant was increased and the responses were enlarged and had lowered thresholds. For the muscles of the replanted hand, the pattern of reorganization was different: Response amplitudes were enlarged but thresholds, COG, and area of the cortical response map were normal. The different reorganizational phenomena observed for the motor cortical areas supplying the replanted hand and the biceps brachii of the same arm may be influenced by a different extent of deafferentation and by their different role in hand motor control.

  6. Reorganization of the brain and heart rhythm during autogenic meditation.

    PubMed

    Kim, Dae-Keun; Rhee, Jyoo-Hi; Kang, Seung Wan

    2014-01-13

    The underlying changes in heart coherence that are associated with reported EEG changes in response to meditation have been explored. We measured EEG and heart rate variability (HRV) before and during autogenic meditation. Fourteen subjects participated in the study. Heart coherence scores were significantly increased during meditation compared to the baseline. We found near significant decrease in high beta absolute power, increase in alpha relative power and significant increases in lower (alpha) and higher (above beta) band coherence during 3~min epochs of heart coherent meditation compared to 3~min epochs of heart non-coherence at baseline. The coherence and relative power increase in alpha band and absolute power decrease in high beta band could reflect relaxation state during the heart coherent meditation. The coherence increase in the higher (above beta) band could reflect cortico-cortical local integration and thereby affect cognitive reorganization, simultaneously with relaxation. Further research is still needed for a confirmation of heart coherence as a simple window for the meditative state.

  7. Light signaling controls nuclear architecture reorganization during seedling establishment

    PubMed Central

    Bourbousse, Clara; Mestiri, Imen; Zabulon, Gerald; Bourge, Mickaël; Formiggini, Fabio; Koini, Maria A.; Brown, Spencer C.; Fransz, Paul; Bowler, Chris; Barneche, Fredy

    2015-01-01

    The spatial organization of chromatin can be subject to extensive remodeling in plant somatic cells in response to developmental and environmental signals. However, the mechanisms controlling these dynamic changes and their functional impact on nuclear activity are poorly understood. Here, we determined that light perception triggers a switch between two different nuclear architectural schemes during Arabidopsis postembryonic development. Whereas progressive nucleus expansion and heterochromatin rearrangements in cotyledon cells are achieved similarly under light and dark conditions during germination, the later steps that lead to mature nuclear phenotypes are intimately associated with the photomorphogenic transition in an organ-specific manner. The light signaling integrators DE-ETIOLATED 1 and CONSTITUTIVE PHOTOMORPHOGENIC 1 maintain heterochromatin in a decondensed state in etiolated cotyledons. In contrast, under light conditions cryptochrome-mediated photoperception releases nuclear expansion and heterochromatin compaction within conspicuous chromocenters. For all tested loci, chromatin condensation during photomorphogenesis does not detectably rely on DNA methylation-based processes. Notwithstanding, the efficiency of transcriptional gene silencing may be impacted during the transition, as based on the reactivation of transposable element-driven reporter genes. Finally, we report that global engagement of RNA polymerase II in transcription is highly increased under light conditions, suggesting that cotyledon photomorphogenesis involves a transition from globally quiescent to more active transcriptional states. Given these findings, we propose that light-triggered changes in nuclear architecture underlie interplays between heterochromatin reorganization and transcriptional reprogramming associated with the establishment of photosynthesis. PMID:25964332

  8. Membrane indentation triggers clathrin lattice reorganization and fluidization.

    PubMed

    Cordella, Nicholas; Lampo, Thomas J; Melosh, Nicholas; Spakowitz, Andrew J

    2015-01-21

    Clathrin-mediated endocytosis involves the coordinated assembly of clathrin cages around membrane indentations, necessitating fluid-like reorganization followed by solid-like stabilization. This apparent duality in clathrin's in vivo behavior provides some indication that the physical interactions between clathrin triskelia and the membrane effect a local response that triggers fluid-solid transformations within the clathrin lattice. We develop a computational model to study the response of clathrin protein lattices to spherical deformations of the underlying flexible membrane. These deformations are similar to the shapes assumed during intracellular trafficking of nanoparticles. Through Monte Carlo simulations of clathrin-on-membrane systems, we observe that these membrane indentations give rise to a greater than normal defect density within the overlaid clathrin lattice. In many cases, the bulk surrounding lattice remains in a crystalline phase, and the extra defects are localized to the regions of large curvature. This can be explained by the fact that the in-plane elastic stress in the clathrin lattice are reduced by coupling defects to highly curved regions. The presence of defects brought about by indentation can result in the fluidization of a lattice that would otherwise be crystalline, resulting in an indentation-driven, defect-mediated phase transition. Altering subunit elasticity or membrane properties is shown to drive a similar transition, and we present phase diagrams that map out the combined effects of these parameters on clathrin lattice properties.

  9. Increased spatial variance accompanies reorganization of two continental shelf ecosystems.

    PubMed

    Litzow, Michael A; Urban, J Daniel; Laurel, Benjamin J

    2008-09-01

    Phase transitions between alternate stable states in marine ecosystems lead to disruptive changes in ecosystem services, especially fisheries productivity. We used trawl survey data spanning phase transitions in the North Pacific (Gulf of Alaska) and the North Atlantic (Scotian Shelf) to test for increases in ecosystem variability that might provide early warning of such transitions. In both time series, elevated spatial variability in a measure of community composition (ratio of cod [Gadus sp.] abundance to prey abundance) accompanied transitions between ecosystem states, and variability was negatively correlated with distance from the ecosystem transition point. In the Gulf of Alaska, where the phase transition was apparently the result of a sudden perturbation (climate regime shift), variance increased one year before the transition in mean state occurred. On the Scotian Shelf, where ecosystem reorganization was the result of persistent overfishing, a significant increase in variance occurred three years before the transition in mean state was detected. However, we could not reject the alternate explanation that increased variance may also have simply been inherent to the final stable state in that ecosystem. Increased variance has been previously observed around transition points in models, but rarely in real ecosystems, and our results demonstrate the possible management value in tracking the variance of key parameters in exploited ecosystems.

  10. Hippocampal-neocortical functional reorganization underlies children's cognitive development.

    PubMed

    Qin, Shaozheng; Cho, Soohyun; Chen, Tianwen; Rosenberg-Lee, Miriam; Geary, David C; Menon, Vinod

    2014-09-01

    The importance of the hippocampal system for rapid learning and memory is well recognized, but its contributions to a cardinal feature of children's cognitive development-the transition from procedure-based to memory-based problem-solving strategies-are unknown. Here we show that the hippocampal system is pivotal to this strategic transition. Longitudinal functional magnetic resonance imaging (fMRI) in 7-9-year-old children revealed that the transition from use of counting to memory-based retrieval parallels increased hippocampal and decreased prefrontal-parietal engagement during arithmetic problem solving. Longitudinal improvements in retrieval-strategy use were predicted by increased hippocampal-neocortical functional connectivity. Beyond childhood, retrieval-strategy use continued to improve through adolescence into adulthood and was associated with decreased activation but more stable interproblem representations in the hippocampus. Our findings provide insights into the dynamic role of the hippocampus in the maturation of memory-based problem solving and establish a critical link between hippocampal-neocortical reorganization and children's cognitive development.

  11. The yeast genome undergoes significant topological reorganization in quiescence

    PubMed Central

    Rutledge, Mark T.; Russo, Mariano; Belton, Jon-Matthew; Dekker, Job; Broach, James R.

    2015-01-01

    We have examined the three-dimensional organization of the yeast genome during quiescence by a chromosome capture technique as a means of understanding how genome organization changes during development. For exponentially growing cells we observe high levels of inter-centromeric interaction but otherwise a predominance of intrachromosomal interactions over interchromosomal interactions, consistent with aggregation of centromeres at the spindle pole body and compartmentalization of individual chromosomes within the nucleoplasm. Three major changes occur in the organization of the quiescent cell genome. First, intrachromosomal associations increase at longer distances in quiescence as compared to growing cells. This suggests that chromosomes undergo condensation in quiescence, which we confirmed by microscopy by measurement of the intrachromosomal distances between two sites on one chromosome. This compaction in quiescence requires the condensin complex. Second, inter-centromeric interactions decrease, consistent with prior data indicating that centromeres disperse along an array of microtubules during quiescence. Third, inter-telomeric interactions significantly increase in quiescence, an observation also confirmed by direct measurement. Thus, survival during quiescence is associated with substantial topological reorganization of the genome. PMID:26202961

  12. Local awakening: regional reorganizations of brain oscillations after sleep.

    PubMed

    Tsai, Pei-Jung; Chen, Sharon Chia-Ju; Hsu, Chun-Yao; Wu, Changwei W; Wu, Yu-Chin; Hung, Ching-Sui; Yang, Albert C; Liu, Po-Yu; Biswal, Bharat; Lin, Ching-Po

    2014-11-15

    Brain functions express rhythmic fluctuations accompanied by sleep and wakefulness each day, but how sleep regulates brain rhythms remains unclear. Following the dose-dependent local sleep concept, two succeeding questions emerge: (1) is the sleep regulation a network-specific process; and (2) is the awakening state dependent on the previous sleep stages? To answer the questions, we conducted simultaneous EEG and fMRI recordings over 22 healthy male participants, along pre-sleep, nocturnal sleep and awakening. Using paired comparisons between awakening and pre-sleep conditions, three scenarios of the regional specificity were demonstrated on awakening: (1) the default-mode and hippocampal networks maintained similar connectivity and spectral power; (2) the sensorimotor network presented reduced connectivity and spectral power; and (3) the thalamus demonstrated substantially enhanced connectivity to the neo-cortex with decreased spectral power. With regard to the stage effect, the deep sleep group had significant changes in both functional connectivity and spectral power on awakening, whereas the indices of light sleep group remained relatively quiescent after sleep. The phenomena implied that slow-wave sleep could be key to rebooting the BOLD fluctuations after sleep. In conclusion, the regional specificity and the stage effect were verified in support of the local awakening concept, indicating that sleep regulation leads to the reorganization of brain networks upon awakening.

  13. Sleep after spatial learning promotes covert reorganization of brain activity.

    PubMed

    Orban, Pierre; Rauchs, Géraldine; Balteau, Evelyne; Degueldre, Christian; Luxen, André; Maquet, Pierre; Peigneux, Philippe

    2006-05-02

    Sleep promotes the integration of recently acquired spatial memories into cerebral networks for the long term. In this study, we examined how sleep deprivation hinders this consolidation process. Using functional MRI, we mapped regional cerebral activity during place-finding navigation in a virtual town, immediately after learning and 3 days later, in subjects either allowed regular sleep (RS) or totally sleep-deprived (TSD) on the first posttraining night. At immediate and delayed retrieval, place-finding navigation elicited increased brain activity in an extended hippocampo-neocortical network in both RS and TSD subjects. Behavioral performance was equivalent between groups. However, striatal navigation-related activity increased more at delayed retrieval in RS than in TSD subjects. Furthermore, correlations between striatal response and behavioral performance, as well as functional connectivity between the striatum and the hippocampus, were modulated by posttraining sleep. These data suggest that brain activity is restructured during sleep in such a way that navigation in the virtual environment, initially related to a hippocampus-dependent spatial strategy, becomes progressively contingent in part on a response-based strategy mediated by the striatum. Both neural strategies eventually relate to equivalent performance levels, indicating that covert reorganization of brain patterns underlying navigation after sleep is not necessarily accompanied by overt changes in behavior.

  14. Cytoskeletal Reorganization Drives Mesenchymal Condensation and Regulates Downstream Molecular Signaling.

    PubMed

    Ray, Poulomi; Chapman, Susan C

    2015-01-01

    Skeletal condensation occurs when specified mesenchyme cells self-organize over several days to form a distinctive cartilage template. Here, we determine how and when specified mesenchyme cells integrate mechanical and molecular information from their environment, forming cartilage condensations in the pharyngeal arches of chick embryos. By disrupting cytoskeletal reorganization, we demonstrate that dynamic cell shape changes drive condensation and modulate the response of the condensing cells to Fibroblast Growth Factor (FGF), Bone Morphogenetic Protein (BMP) and Transforming Growth Factor beta (TGF-β) signaling pathways. Rho Kinase (ROCK)-driven actomyosin contractions and Myosin II-generated differential cell cortex tension regulate these cell shape changes. Disruption of the condensation process inhibits the differentiation of the mesenchyme cells into chondrocytes, demonstrating that condensation regulates the fate of the mesenchyme cells. We also find that dorsal and ventral condensations undergo distinct cell shape changes. BMP signaling is instructive for dorsal condensation-specific cell shape changes. Moreover, condensations exhibit ventral characteristics in the absence of BMP signaling, suggesting that in the pharyngeal arches ventral morphology is the ground pattern. Overall, this study characterizes the interplay between cytoskeletal dynamics and molecular signaling in a self-organizing system during tissue morphogenesis.

  15. Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome

    PubMed Central

    MacMillan, Heath A.; Knee, Jose M.; Dennis, Alice B.; Udaka, Hiroko; Marshall, Katie E.; Merritt, Thomas J. S.; Sinclair, Brent J.

    2016-01-01

    Cold tolerance is a key determinant of insect distribution and abundance, and thermal acclimation can strongly influence organismal stress tolerance phenotypes, particularly in small ectotherms like Drosophila. However, there is limited understanding of the molecular and biochemical mechanisms that confer such impressive plasticity. Here, we use high-throughput mRNA sequencing (RNA-seq) and liquid chromatography – mass spectrometry (LC-MS) to compare the transcriptomes and metabolomes of D. melanogaster acclimated as adults to warm (rearing) (21.5 °C) or cold conditions (6 °C). Cold acclimation improved cold tolerance and led to extensive biological reorganization: almost one third of the transcriptome and nearly half of the metabolome were differentially regulated. There was overlap in the metabolic pathways identified via transcriptomics and metabolomics, with proline and glutathione metabolism being the most strongly-supported metabolic pathways associated with increased cold tolerance. We discuss several new targets in the study of insect cold tolerance (e.g. dopamine signaling and Na+-driven transport), but many previously identified candidate genes and pathways (e.g. heat shock proteins, Ca2+ signaling, and ROS detoxification) were also identified in the present study, and our results are thus consistent with and extend the current understanding of the mechanisms of insect chilling tolerance. PMID:27357258

  16. 29 CFR 24.114 - District court jurisdiction of retaliation complaints under the Energy Reorganization Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ENVIRONMENTAL STATUTES AND SECTION 211 OF THE ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Miscellaneous... faith of the complainant, the complainant may bring an action at law or equity for de novo review in...

  17. 29 CFR 24.114 - District court jurisdiction of retaliation complaints under the Energy Reorganization Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ENVIRONMENTAL STATUTES AND SECTION 211 OF THE ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Miscellaneous... faith of the complainant, the complainant may bring an action at law or equity for de novo review in...

  18. 29 CFR 24.114 - District court jurisdiction of retaliation complaints under the Energy Reorganization Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ENVIRONMENTAL STATUTES AND SECTION 211 OF THE ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Miscellaneous... faith of the complainant, the complainant may bring an action at law or equity for de novo review in...

  19. Theoretical study of substitution effects on molecular reorganization energy in organic semiconductors.

    PubMed

    Geng, Hua; Niu, Yingli; Peng, Qian; Shuai, Zhigang; Coropceanu, Veaceslav; Brédas, Jean-Luc

    2011-09-14

    Chemical substitutions are powerful molecular design tools to enhance the performance of organic semiconductors, for instance, to improve solubility, intermolecular stacking, or film quality. However, at the microscopic level, substitutions in general tend to increase the molecular reorganization energy and thus decrease the intrinsic charge-carrier mobility. Through density functional theory calculations, we elucidate strategies that could be followed to reduce the reorganization energy upon chemical substitution. Specific examples are given here for hole-transport materials including indolo-carbazoles and several triarylamine derivatives. Through decomposition of the total reorganization energy into the internal coordinate space, we are able to identify the molecular segment that provides the most important contributions to the reorganization energy. It is found that when substitution reduces (enhances) the amplitude of the relevant frontier molecular orbital in that segment, the total reorganization energy decreases (increases). In particular, chlorination at appropriate positions can significantly reduce the reorganization energy. Several other substituents are shown to play a similar role, to a greater or lesser extent.

  20. Ethacrynic Acid Inhibits Sphingosylphosphorylcholine-Induced Keratin 8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition.

    PubMed

    Byun, Hyun Jung; Kang, Kyung Jin; Park, Mi Kyung; Lee, Hye Ja; Kang, June Hee; Lee, Eun Ji; Kim, You Ri; Kim, Hyun Ji; Kim, Young Woo; Jung, Kyung Chae; Kim, Soo Youl; Lee, Chang Hoon

    2013-09-30

    Sphingosylphosphorylcholine (SPC) is significantly increased in the malicious ascites of tumor patients and induces perinuclear reorganization of keratin 8 (K8) filaments in PANC-1 cells. The reorganization contributes to the viscoelasticity of metastatic cancer cells resulting in increased migration. Recently, we reported that transglutaminase-2 (Tgase-2) is involved in SPC-induced K8 phosphorylation and reorganization. However, effects of Tgase-2 inhibitors on SPC-induced K8 phosphorylation and reorganization were not clearly studied. We found that ethacrynic acid (ECA) concentration-dependently inhibited Tgase-2. Therefore, we examined the effects of ECA on SPC-induced K8 phosphorylation and reorganization. ECA concentration-dependently suppressed the SPC-induced phosphorylation and perinuclear reorganization of K8. ECA also suppressed the SPC-induced migration and invasion. SPC induced JNK activation through Tgase-2 expression and ECA suppressed the activation and expression of JNK in PANC-1 cells. These results suggested that ECA might be useful to control Tgase-2 dependent metastasis of cancer cells such as pancreatic cancer and lung cancers.

  1. Motor unit reorganization in progressive muscular dystrophies and congenital myopathies.

    PubMed

    Szmidt-Sałkowska, Elżbieta; Gaweł, Małgorzata; Lipowska, Marta

    2015-01-01

    The aim of this study was to analyze motor unit reorganization in different types of progressive muscular dystrophies and congenital myopathies. The study population consisted of patients with genetically verified progressive muscular dystrophies: Duchenne (DMD) (n=54), Becker (BMD) (n=30), facio-scapulo-humeral (FSHD) (n=37), and Emery-Dreifuss (E-DD) (n=26). Patients with probable limb-girdle dystrophy (L-GD) (n=58) and congenital myopathies (n=35) were also included in the study. Quantitative EMG recordings were obtained from 469 muscles. Muscle activity at rest and during slight voluntary and maximal muscle contraction was analyzed. The motor unit activity potential (MUAP) duration, amplitude, area, size index (SI), polyphasicity, and the presence of "outliers" were evaluated. Diminished values of MUAP parameters and decreased maximal amplitude of maximal muscle contraction were recorded most frequently in DMD and mainly in the biceps brachii muscles. SI was the most frequently changed EMG parameter. "Outliers" with amplitude below the normal range were recorded more frequently then a decreased mean MUAP amplitude (what could indicate a very high sensitivity of this EMG parameter). Pathological interference pattern was recorded in 34.7% of biceps brachii and in 21.2% of rectus femoris muscles. In FSHD, decreased MUAP duration and SI and pathological interference pattern with low amplitude were recorded most frequently in the tibial anterior and deltoid muscles. The presence of potentials with reduced parameters is a result of decreasing motor unit area (reduced number and size of muscle fibers), while high amplitude potentials recorded in BMD and E-DD could indicate a slow and mild course of disease and muscle regeneration.

  2. Revocation of tax-exempt status, excise taxes, and other intermediate sanctions issues, plus income taxes: how the rules have changed after Caracci v. Commissioner.

    PubMed

    King, James R; Boyce, David S

    2003-01-01

    This Article discusses Caracci v. Commissioner, in which the Tax Court imposed intermediate sanctions based on its finding that insiders caused three applicable tax-exempt organizations to sell assets to three for-profit entities owned and controlled by those same insiders. It explores the standards enumerated in Caracci, hypothesizes as to the pending appeal, and examines the guidance given by the decision's clarification of the intermediate sanctions provisions of the Internal Revenue Code.

  3. 24 CFR 200.931 - Statement of availability.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... for public examination in the Office of Consumer and Regulatory Affairs, Department of Housing and... (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING...

  4. Morphological reorganization within the Pacific-Antarctic Discordance

    NASA Astrophysics Data System (ADS)

    Sahabi, Mohamed; Géli, Louis; Olivet, Jean-Louis; Gilg-Capar, Laure; Roult, Geneviève; Ondréas, Hélène; Beuzart, Paul; Aslanian, Daniel

    1996-01-01

    Two domains with different satellite gravity signatures [1] appear along the axis and on the adjacent basins of the Pacific-Antarctic Ridge (PAR) between Udintsev FZ and 180°W. One of these signatures is of rough and faulted seafloor, with a high density of apparent, well-marked fracture zones; the other is of smooth seafloor that is comparable with that of oceanic basins that are generally formed at fast-spreading centres. Between Udintsev FZ and 157°W these two domains are separated by a V-shaped structure that extends for more than 1000 km along the rise axis, whereas west of 157°W the boundary is more diffuse. The satellite gravity also reveals an abrupt change in the axial morphology of the PAR across FZ XII, despite the fact that the current spreading rate [2] is the same on both sides of the fracture zone (about 60 mm/yr, full rate). To interpret these features, we postulate that the domains with an apparently rough seafloor morphology have been created at a spreading centre with an axial valley, and that smooth morphology testifies to a spreading centre which was with or evolving into an axial high at the time the crust was formed. With this hypothesis, we show that, since An 21o time (ca. 48 Ma), the ridge morphology changed from an axial valley to an axial high wherever and whenever the spreading rate exceeded a given threshold value. We also show that there is no unique threshold value. Geophysical evidence suggests that the differences in spreading rate threshold values that we observe are probably related to upper mantle temperature heterogeneities below the axis of the PAR. Therefore, we conclude that changes in spreading rates, combined with changes in the upper mantle temperature, constitute the key process that has governed the morphological reorganization of the PAR between Udintsev FZ and 180°W since An 21o time. The cause of upper mantle temperature heterogeneities, however, remains an open question. The 1000 km long 'V' south of Udintsev FZ

  5. Superinfection Exclusion in Alphabaculovirus Infections Is Concomitant with Actin Reorganization

    PubMed Central

    Beperet, Inés; Irons, Sarah L.; Simón, Oihane; King, Linda A.; Williams, Trevor; Possee, Robert D.; Caballero, Primitivo

    2014-01-01

    ABSTRACT Superinfection exclusion is the ability of an established virus to interfere with a second virus infection. This effect was studied in vitro during lepidopteran-specific nucleopolyhedrovirus (genus Alphabaculovirus, family Baculoviridae) infection. Homologous interference was detected in Sf9 cells sequentially infected with two genotypes of Autographa californica multiple nucleopolyhedrovirus (AcMNPV), each one expressing a different fluorescent protein. This was a progressive process in which a sharp decrease in the signs of infection caused by the second virus was observed, affecting not only the number of coinfected cells observed, but also the level of protein expression due to the second virus infection. Superinfection exclusion was concurrent with reorganization of cytoplasmic actin to F-actin in the nucleus, followed by budded virus production (16 to 20 h postinfection). Disruption of actin filaments by cell treatment with cytochalasin D resulted in a successful second infection. Protection against heterologous nucleopolyhedrovirus infection was also demonstrated, as productive infection of Sf9 cells by Spodoptera frugiperda nucleopolyhedrovirus (SfMNPV) was inhibited by prior infection with AcMNPV, and vice versa. Finally, coinfected cells were observed following inoculation with mixtures of these two phylogenetically distant nucleopolyhedroviruses—AcMNPV and SfMNPV—but at a frequency lower than predicted, suggesting interspecific virus interference during infection or replication. The temporal window of infection is likely necessary to maintain genotypic diversity that favors virus survival but also permits dual infection by heterospecific alphabaculoviruses. IMPORTANCE Infection of a cell by more than one virus particle implies sharing of cell resources. We show that multiple infection, by closely related or distantly related baculoviruses, is possible only during a brief window of time that allows additional virus particles to enter an

  6. Quaternary Reorganization of North American Mid-continent Drainage Systems

    NASA Astrophysics Data System (ADS)

    Carson, E. C.; Rawling, J. E., III; Attig, J. W.; Bates, B. R.

    2013-12-01

    changes to the total discharge of the St. Lawrence and Mississippi Rivers. While it is unclear if the Teays River ever flowed into the St. Lawrence drainage or developed as a westward-flowing tributary to the buried Mahomet valley in Illinois, both the ancestral Pittsburgh and Wyalusing Rivers originated as headwaters of the St. Lawrence basin before being rerouted as part of the Mississippi basin. The areas formerly drained by the Pittsburgh and Wyalusing Rivers comprise ~8% of the modern Mississippi River basin, and modern discharge from those areas represent ~14% of the mean annual discharge of the Mississippi River. The transfer of this drainage area and discharge to the Mississippi basin is mirrored by an equivalent loss from the St. Lawrence system during the Quaternary as a direct result of glacially-driven drainage system reorganization.

  7. 76 FR 63957 - Consumer Product Policy Statement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-14

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Consumer Product Policy Statement AGENCY: Nuclear Regulatory Commission. ACTION: Proposed revision to policy statement; request for public comment. SUMMARY: The U.S. Nuclear Regulatory Commission...

  8. 77 FR 43137 - Aviation Environmental and Energy Policy Statement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... Federal Aviation Administration Aviation Environmental and Energy Policy Statement AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Policy Statement. SUMMARY: This is a statement affirming the FAA's environmental and energy policy for U.S. civil aviation. This policy statement outlines...

  9. 20 CFR 335.3 - Execution of statement of sickness and supplemental doctor's statement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... supplemental doctor's statement. 335.3 Section 335.3 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS... sickness and supplemental doctor's statement. (a) Who may execute. A statement of sickness and any required supplemental doctor's statement shall be executed by any of the following individuals: (1) A licensed...

  10. School Library Policy Statement. Revised.

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education and Training, Winnipeg. Instructional Services Branch.

    A school library program is a basic component of education for all students. Manitoba Education and Training (MET) presents this policy statement to clarify the roles of the provincial government and the school districts in providing school library services. MET will provide policy and guideline documents to recommend standards, and funding…

  11. Paradigm Statements of Educational Objectives.

    ERIC Educational Resources Information Center

    Gray, Peter J.

    Five distinct format categories are used in this study to describe the form of educational objectives: clarity, range, level of abstractness, behavioralness, and observability. These form concepts are used to describe paradigm statements of three kinds of educational objectives: goals, intended learning outcomes, and behavioral evidence. Goals are…

  12. 2009 Elections: The Candidates Statements

    ERIC Educational Resources Information Center

    TechTrends: Linking Research and Practice to Improve Learning, 2009

    2009-01-01

    This article presents the candidates for the 2009 Association for Educational Communications and Technology (AECT) election and their statements. The candidates are: (1) Andy Gibbons (President-Elect); (2) Barbara B. Lockee (President-Elect); (3) Mary Jean Bishop (At-Large Representative); and (4) Deepak Subramony (At-Large Representative). In…

  13. Consensus Statement Immunonutrition and Exercise.

    PubMed

    Bermon, Stephane; Castell, Lindy M; Calder, Philip C; Bishop, Nicolette C; Blomstrand, Eva; Mooren, Frank C; Krüger, Karsten; Kavazis, Andreas N; Quindry, John C; Senchina, David S; Nieman, David C; Gleeson, Michael; Pyne, David B; Kitic, Cecilia M; Close, Graeme L; Larson-Meyer, D Enette; Marcos, Ascension; Meydani, Simin N; Walsh, Neil P; Nagatomi, Ryochi

    2017-01-01

    In this consensus statement on immunonutrition and exercise, a panel of knowledgeable contributors from across the globe provides a consensus of updated science, including the background, the aspects for which a consensus actually exists, the controversies and, when possible, suggested directions for future research.

  14. Accounting Principles and Financial Statements.

    ERIC Educational Resources Information Center

    Robinson, Daniel D.

    1973-01-01

    This document presents the background and analysis of the American Institute of Certified Public Accountants (AICPA) guide to auditing colleges and universities. Highlights include the approval of the market value option, the treatment of endowment gains, debt services as transfers, the decisions on pledges, the use of financial statements, the…

  15. Graphs as Statements of Belief.

    ERIC Educational Resources Information Center

    Lake, David

    2002-01-01

    Identifies points where beliefs are important when making decisions about how graphs are drawn. Describes a simple case of the reaction between 'bicarb soda' and orange or lemon juice and discusses how drawing a graph becomes a statement of belief. (KHR)

  16. Biological Awareness: Statements for Self-Discovery.

    ERIC Educational Resources Information Center

    Edington, D.W.; Cunningham, Lee

    This guide to biological awareness through guided self-discovery is based on 51 single focus statements concerning the human body. For each statement there are explanations of the underlying physiological principles and suggested activities and discussion ideas to encourage understanding of the statement in terms of the human body's functions,…

  17. 78 FR 31924 - Appraisal Subcommittee; Policy Statements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... practice and reciprocity. Since 1997, the Policy Statements have remained largely unchanged with the... Statement 5: Reciprocity. The proposed Policy Statement addressed reciprocity policies consistent with Title XI. The Dodd-Frank act amended the Title XI provision on reciprocity to require that in order for...

  18. 75 FR 22577 - Proposed Privacy Policy Statement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-29

    ... COMMISSION Proposed Privacy Policy Statement AGENCY: U.S. Election Assistance Commission. ACTION: Notice and request for public comment on Proposed Privacy Policy Statement. SUMMARY: The U.S. Election Assistance Commission (EAC) seeks public comment on the Proposed Privacy Policy Statement. OMB Memorandum M-99-...

  19. 76 FR 54637 - Board Policy Statements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ... September 1, 2011 Part IV Farm Credit Administration 12 CFR Chapter VI Board Policy Statements; Rule #0;#0... CREDIT ADMINISTRATION 12 CFR Chapter VI Board Policy Statements AGENCY: Farm Credit Administration. ACTION: Policy statements. SUMMARY: The Farm Credit Administration (FCA) Board recently undertook its...

  20. 12 CFR 327.2 - Certified statements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ASSESSMENTS In General § 327.2 Certified statements. (a) Required. (1) The certified statement shall also be...) The quarterly certified statement invoice shall reflect the institution's risk assignment, assessment base, assessment computation, and assessment amount, for each quarterly assessment period....

  1. 42 CFR 460.208 - Financial statements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Financial statements. 460.208 Section 460.208... ELDERLY (PACE) Data Collection, Record Maintenance, and Reporting § 460.208 Financial statements. (a... must submit a certified financial statement that includes appropriate footnotes. (2) The...

  2. 42 CFR 460.208 - Financial statements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Financial statements. 460.208 Section 460.208... ELDERLY (PACE) Data Collection, Record Maintenance, and Reporting § 460.208 Financial statements. (a... must submit a certified financial statement that includes appropriate footnotes. (2) The...

  3. 7 CFR 3052.310 - Financial statements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Financial statements. 3052.310 Section 3052.310 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER....310 Financial statements. (a) Financial statements. The auditee shall prepare financial...

  4. 7 CFR 1212.51 - Financial statements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Financial statements. 1212.51 Section 1212.51..., Promotion, Consumer Education, and Industry Information Order Expenses and Assessments § 1212.51 Financial statements. (a) The Board shall prepare and submit financial statements to the Department on a periodic...

  5. 7 CFR 1221.113 - Financial statements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Financial statements. 1221.113 Section 1221.113... Information Board § 1221.113 Financial statements. (a) As requested by the Secretary, the Board shall prepare and submit financial statements to the Secretary on a monthly basis. Each such financial...

  6. 42 CFR 460.208 - Financial statements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Financial statements. 460.208 Section 460.208... ELDERLY (PACE) Data Collection, Record Maintenance, and Reporting § 460.208 Financial statements. (a... must submit a certified financial statement that includes appropriate footnotes. (2) The...

  7. 7 CFR 1221.113 - Financial statements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Financial statements. 1221.113 Section 1221.113... Information Board § 1221.113 Financial statements. (a) As requested by the Secretary, the Board shall prepare and submit financial statements to the Secretary on a monthly basis. Each such financial...

  8. 7 CFR 3052.310 - Financial statements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Financial statements. 3052.310 Section 3052.310 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF THE CHIEF FINANCIAL OFFICER....310 Financial statements. (a) Financial statements. The auditee shall prepare financial...

  9. 42 CFR 460.208 - Financial statements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Financial statements. 460.208 Section 460.208... ELDERLY (PACE) Data Collection, Record Maintenance, and Reporting § 460.208 Financial statements. (a... must submit a certified financial statement that includes appropriate footnotes. (2) The...

  10. 7 CFR 1221.113 - Financial statements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Financial statements. 1221.113 Section 1221.113... Information Board § 1221.113 Financial statements. (a) As requested by the Secretary, the Board shall prepare and submit financial statements to the Secretary on a monthly basis. Each such financial...

  11. 7 CFR 1217.51 - Financial statements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Financial statements. 1217.51 Section 1217.51... Education, and Industry Information Order Expenses and Assessments § 1217.51 Financial statements. (a) The Board shall prepare and submit financial statements to the Department on a quarterly basis, or at...

  12. 7 CFR 1214.51 - Financial statements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Financial statements. 1214.51 Section 1214.51... Assessments § 1214.51 Financial statements. (a) The Board shall prepare and submit quarterly financial statements to the Secretary, or at any other time requested by the Secretary. Each such financial...

  13. 7 CFR 1212.51 - Financial statements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Financial statements. 1212.51 Section 1212.51..., Promotion, Consumer Education, and Industry Information Order Expenses and Assessments § 1212.51 Financial statements. (a) The Board shall prepare and submit financial statements to the Department on a periodic...

  14. 7 CFR 4279.237 - Financial statements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Financial statements. 4279.237 Section 4279.237... § 4279.237 Financial statements. The provisions of § 4279.137 do not apply to this subpart. Instead, the submittal of financial statements with the loan guarantee application must meet the requirements...

  15. 42 CFR 460.208 - Financial statements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 4 2013-10-01 2013-10-01 false Financial statements. 460.208 Section 460.208... ELDERLY (PACE) Data Collection, Record Maintenance, and Reporting § 460.208 Financial statements. (a... must submit a certified financial statement that includes appropriate footnotes. (2) The...

  16. 16 CFR 500.24 - Supplemental statements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Supplemental statements. 500.24 Section 500.24 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENT OF GENERAL POLICY OR... PACKAGING AND LABELING ACT § 500.24 Supplemental statements. Nothing contained in the regulations in...

  17. A qualitative study of diverse providers' behaviour in response to commissioners, patients and innovators in England: research protocol

    PubMed Central

    Sheaff, Rod; Halliday, Joyce; Exworthy, Mark; Allen, Pauline; Mannion, Russell; Asthana, Sheena; Gibson, Alex; Clark, Jonathan

    2016-01-01

    Introduction The variety of organisations providing National Health Service (NHS)-funded services in England is growing. Besides NHS hospitals and general practitioners (GPs), they include corporations, social enterprises, voluntary organisations and others. The degree to which these organisational types vary, however, in the ways they manage and provide services and in the outcomes for service quality, patient experience and innovation, remains unclear. This research will help those who commission NHS services select among the different types of organisation for different tasks. Research questions The main research questions are how organisationally diverse NHS-funded service providers vary in their responsiveness to patient choice, NHS commissioning and policy changes; and their patterns of innovation. We aim to assess the implications for NHS commissioning and managerial practice which follow from these differences. Methods and analysis Systematic qualitative comparison across a purposive sample (c.12) of providers selected for maximum variety of organisational type, with qualitative studies of patient experience and choice (in the same sites). We focus is on NHS services heavily used by older people at high risk of hospital admission: community health services; out-of-hours primary care; and secondary care (planned orthopaedics or ophthalmology). The expected outputs will be evidence-based schemas showing how patterns of service development and delivery typically vary between different organisational types of provider. Ethics, benefits and dissemination We will ensure informants' organisational and individual anonymity when dealing with high profile case studies and a competitive health economy. The frail elderly is a key demographic sector with significant policy and financial implications. For NHS commissioners, patients, doctors and other stakeholders, the main outcome will be better knowledge about the relative merits of different kinds of healthcare

  18. Reorganization of visual processing in macular degeneration is not specific to the "preferred retinal locus".

    PubMed

    Dilks, Daniel D; Baker, Chris I; Peli, Eli; Kanwisher, Nancy

    2009-03-04

    Recent work has shown that foveal cortex, deprived of its normal bottom-up input as a result of macular degeneration (MD), begins responding to stimuli presented to a peripheral retinal location. However, these studies have only presented stimuli to the "preferred retinal location," or PRL, a spared part of the peripheral retina used by individuals with MD for fixating, face recognition, reading, and other visual tasks. Thus, previous research has not yet answered a question critical for understanding the mechanisms underlying this reorganization: Does formerly foveal cortex respond only to stimuli presented at the PRL, or does it also respond to other peripheral locations of similar eccentricity? If foveal cortex responds to stimuli at PRL because it is the long-term habitual use of this region as a functional fovea that drives the formerly foveal cortex to respond to stimuli presented at the PRL (the "use-dependent reorganization" hypothesis), then foveal cortex will not respond to stimuli presented at other locations. Alternatively, it may be that foveal cortex responds to any peripheral retinal input, independent of whether input at that retinal location has been chronically attended for months or years (the "use-independent reorganization" hypothesis). Using fMRI, we found clear activation of formerly foveal cortex to stimuli presented at either the PRL or an isoeccentric non-PRL location in two individuals with MD, supporting the use-independent reorganization hypothesis. This finding suggests that reorganization is driven by passive, not use-dependent mechanisms.

  19. Extrastriate visual cortex reorganizes despite sequential bilateral occipital stroke: implications for vision recovery.

    PubMed

    Brodtmann, Amy; Puce, Aina; Darby, David; Donnan, Geoffrey

    2015-01-01

    The extent of visual cortex reorganization following injury remains controversial. We report serial functional magnetic resonance imaging (fMRI) data from a patient with sequential posterior circulation strokes occurring 3 weeks apart, compared with data from an age-matched healthy control subject. At 8 days following a left occipital stroke, contralesional visual cortical activation was within expected striate and extrastriate sites, comparable to that seen in controls. Despite a further infarct in the right (previously unaffected hemisphere), there was evolution of visual cortical reorganization progressed. In this patient, there was evidence of utilization of peri-infarct sites (right-sided) and recruitment of new activation sites in extrastriate cortices, including in the lateral middle and inferior temporal lobes. The changes over time corresponded topographically with the patient's lesion site and its connections. Reorganization of the surviving visual cortex was demonstrated 8 days after the first stroke. Ongoing reorganization in extant cortex was demonstrated at the 6 month scan. We present a summary of mechanisms of recovery following stroke relevant to the visual system. We conclude that mature primary visual cortex displays considerable plasticity and capacity to reorganize, associated with evolution of visual field deficits. We discuss these findings and their implications for therapy within the context of current concepts in visual compensatory and restorative therapies.

  20. Extrastriate visual cortex reorganizes despite sequential bilateral occipital stroke: implications for vision recovery

    PubMed Central

    Brodtmann, Amy; Puce, Aina; Darby, David; Donnan, Geoffrey

    2015-01-01

    The extent of visual cortex reorganization following injury remains controversial. We report serial functional magnetic resonance imaging (fMRI) data from a patient with sequential posterior circulation strokes occurring 3 weeks apart, compared with data from an age-matched healthy control subject. At 8 days following a left occipital stroke, contralesional visual cortical activation was within expected striate and extrastriate sites, comparable to that seen in controls. Despite a further infarct in the right (previously unaffected hemisphere), there was evolution of visual cortical reorganization progressed. In this patient, there was evidence of utilization of peri-infarct sites (right-sided) and recruitment of new activation sites in extrastriate cortices, including in the lateral middle and inferior temporal lobes. The changes over time corresponded topographically with the patient's lesion site and its connections. Reorganization of the surviving visual cortex was demonstrated 8 days after the first stroke. Ongoing reorganization in extant cortex was demonstrated at the 6 month scan. We present a summary of mechanisms of recovery following stroke relevant to the visual system. We conclude that mature primary visual cortex displays considerable plasticity and capacity to reorganize, associated with evolution of visual field deficits. We discuss these findings and their implications for therapy within the context of current concepts in visual compensatory and restorative therapies. PMID:25972800

  1. A molecular Debye-Hückel approach to the reorganization energy of electron transfer reactions in an electric cell.

    PubMed

    Xiao, Tiejun; Song, Xueyu

    2014-10-07

    Electron transfer near an electrode immersed in ionic fluids is studied using the linear response approximation, namely, mean value of the vertical energy gap can be used to evaluate the reorganization energy, and hence any linear response model that can treat Coulomb interactions successfully can be used for the reorganization energy calculation. Specifically, a molecular Debye-Hückel theory is used to calculate the reorganization energy of electron transfer reactions in an electric cell. Applications to electron transfer near an electrode in molten salts show that the reorganization energies from our molecular Debye-Hückel theory agree well with the results from MD simulations.

  2. Plasma membrane reorganization induced by tumor promoters in an epithelial cell line

    SciTech Connect

    PACKARD, BEVERLY S.; SAXTON, MICHAEL J.; BISSELL, MINA J.; KLEIN, MELVIN P.

    1984-01-01

    The effects of phorbol ester tumor promoters on the lateral diffusion in plasma membrane lipid environments were examined by the technique of fluorescence recovery after photobleaching. To this end, the probe collarein, a fluorescent lipid analog that has the property of exclusive localization in the plasma membrane, was synthesized. Measured decreases in three parameters [percentage of fluorescence bleached (30%), percentage of recovery (52%), and half-time for recovery (52%)] connoted the appearance of an immobile fraction upon exposure to tumor promoters. These data are consistent with lipid reorganization in response to a reorganization of the intra- and perimembranous macromolecular scaffolding upon the interaction of cells with tumor promoters. The idea of induced reorganization is supported by experiments in which cell shape change, brought about by either exposure to cytochalasin B or growth on matrices of collagen, fibronectin, or laminin, resulted in values in the fluorescence recovery after photobleaching technique similar to those with active phorbol esters.

  3. [Structural and functional reorganization of photosynthetic apparatus in cold adaptation of wheat plants].

    PubMed

    Venzhik, Ju V; Titov, D F; Talanova, V V; Miroslavov, E D; Koteeva, N K

    2012-01-01

    The structural and functional characteristics of the photosynthetic apparatus (PSA) and the cold resistance of wheat seedlings were studied during low-temperature adaptation. It has been established that large chloroplasts with thylakoid system of "sun type" forme in the mesophyll cells in the early hours of plants hardening. At the same time the functional reorganization of the PSA in the leaves of wheat occurs: content of pigments changes, stabilization of the pigment-protein complexes is observed, non-photochemical quenching of excess energy increases. The stabilization of photosynthesis during cold adaptation occurs due to structural and functional reorganization of the PSA. It is assumed that the reorganization of the PSA is a prerequisite for formation of increased cold resistance of leaf cells, and this, along with other physiological and biochemical changes occurring in cells and tissues of plants, allows the plants to survive in chilling.

  4. Consolidated financial statements for fiscal year 1996

    SciTech Connect

    1997-02-01

    The following overview and accompanying audited financial statements have been prepared for Fiscal Year (FY) 1996 to report the financial position and the results of operations of the Department of Energy. These statements include the consolidated Statement of Financial Position and the consolidated Statement of Operations and Changes in Net Position. The statements have been prepared in accordance with the Office of Management and Budget Bulletin No. 94-01, Form and Content for Agency Financial Statements, and were developed in accordance with the hierarchy of accounting standards described therein. The overview provides a narrative on the Department of Energy`s mission, activities, and accomplishments. Utilizing performance measures as the primary vehicle for communicating Departmental accomplishments and results, this overview discusses the most significant measures while others are discussed in the supplemental information to the financial statements.

  5. Inter-hemispheric language functional reorganization in low-grade glioma patients after tumour surgery.

    PubMed

    Kristo, Gert; Raemaekers, Mathijs; Rutten, Geert-Jan; de Gelder, Beatrice; Ramsey, Nick F

    2015-03-01

    Despite many claims of functional reorganization following tumour surgery, empirical studies that investigate changes in functional activation patterns are rare. This study investigates whether functional recovery following surgical treatment in patients with a low-grade glioma in the left hemisphere is linked to inter-hemispheric reorganization. Based on literature, we hypothesized that reorganization would induce changes in the spatial pattern of activation specifically in tumour homologue brain areas in the healthy right hemisphere. An experimental group (EG) of 14 patients with a glioma in the left hemisphere near language related brain areas, and a control group of 6 patients with a glioma in the right, non-language dominant hemisphere were scanned before and after resection. In addition, an age and gender matched second control group of 18 healthy volunteers was scanned twice. A verb generation task was used to map language related areas and a novel technique was used for data analysis. Contrary to our hypothesis, we found that functional recovery following surgery of low-grade gliomas cannot be linked to functional reorganization in language homologue brain areas in the healthy, right hemisphere. Although elevated changes in the activation pattern were found in patients after surgery, these were largest in brain areas in proximity to the surgical resection, and were very similar to the spatial pattern of the brain shift following surgery. This suggests that the apparent perilesional functional reorganization is mostly caused by the brain shift as a consequence of surgery. Perilesional functional reorganization can however not be excluded. The study suggests that language recovery after transient post-surgical language deficits involves recovery of functioning of the presurgical language system.

  6. Sleep Strengthens but does Not Reorganize Memory Traces in a Verbal Creativity Task

    PubMed Central

    Landmann, Nina; Kuhn, Marion; Maier, Jonathan-Gabriel; Feige, Bernd; Spiegelhalder, Kai; Riemann, Dieter; Nissen, Christoph

    2016-01-01

    Study Objectives: Sleep after learning promotes the quantitative strengthening of new memories. Less is known about the impact of sleep on the qualitative reorganization of memory content. This study tested the hypothesis that sleep facilitates both memory strengthening and reorganization as indexed by a verbal creativity task. Methods: Sixty healthy university students (30 female, 30 male, 20–30 years) were investigated in a randomized, controlled parallel-group study with three experimental groups (sleep, sleep deprivation, daytime wakefulness). At baseline, 60 items of the Compound Remote Associate (CRA) task were presented. At retest after the experimental conditions, the same items were presented again together with 20 new control items to disentangle off-line incubation from online performance effects. Results: Sleep significantly strengthened formerly encoded memories in comparison to both wake conditions (improvement in speed of correctly resolved items). Offline reorganization was not enhanced following sleep, but was enhanced following sleep-deprivation in comparison to sleep and daytime wakefulness (solution time of previously incubated, newly solved items). Online performance did not differ between the groups (solution time of new control items). Conclusions: The results support the notion that sleep promotes the strengthening, but not the reorganization, of newly encoded memory traces in a verbal creativity task. Future studies are needed to further determine the impact of sleep on different types of memory reorganization, such as associative thinking, creativity and emotional memory processing, and potential clinical translations, such as the augmentation of psychotherapy through sleep interventions. Citation: Landmann N, Kuhn M, Maier JG, Feige B, Spiegelhalder K, Riemann D, Nissen C. Sleep strengthens but does not reorganize memory traces in a verbal creativity task. SLEEP 2016;39(3):705–713. PMID:26518596

  7. Reorganization of brain function during force production after stroke: A Systematic Review of the Literature

    PubMed Central

    Kokotilo, Kristen J; Eng, Janice J; Boyd, Lara A

    2011-01-01

    Damage to motor areas of the brain, caused by stroke, can produce devastating motor deficits, including aberrant control of force. Reorganization of brain function has been identified as one of the fundamental mechanisms involved in recovery of motor control after stroke, and recent advances in neuroimaging have enabled study of this brain reorganization. This review focuses on neuroimaging studies that have examined reorganization of brain function during force production and force modulation after stroke. Type and extent of reorganization after stroke was characterized via three factors: severity of injury, time after stroke and the impact of therapeutic interventions on brain activation during force production. Twenty-six studies meeting the inclusion criteria could be identified in MEDLINE (1980 to 2007). Relevant characteristics of studies (lesion location, chronicity of stroke, motor task) and mapping techniques varied widely. During force production, increased activation in secondary motor areas occurred in persons with more severe strokes. Also, reduced recruitment of secondary motor areas during force production was found as a function of increased time since stroke. During force modulation, increased activation in motor areas occurred with greater force generation. In addition, persons with more severe stroke showed relatively greater activation with rising force as compared to persons with less severe stroke. Lastly, alteration of brain activation during and after rehabilitative interventions in persons with stroke occurred in some studies. This systematic review establishes that reorganization of brain function during force production and force modulation can occur after stroke. These findings imply that therapeutic strategies that may be able to target brain reorganization to improve force control and functional recovery after stroke. PMID:19265770

  8. Survivor reactions to reorganization: antecedents and consequences of procedural, interpersonal, and informational justice.

    PubMed

    Kernan, Mary C; Hanges, Paul J

    2002-10-01

    This study tested a model of survivor reactions to reorganization, which incorporated multiple predictors and consequences of procedural, interpersonal, and informational justice. The 3 justice types had different correlates: all 4 antecedents (employee input, victim support, implementation, and communication quality) predicted interpersonal fairness, implementation and communication quality were associated with informational fairness, and employee input was the sole predictor of procedural justice. Procedural justice was strongly related to all 4 outcome variables, and interpersonal and informational justice added unique variance to the prediction of trust in management. The reorganization effort was still predictive of employee outcomes, although primarily through procedural justice approximately I year after its completion.

  9. What do external consultants from private and not-for-profit companies offer healthcare commissioners? A qualitative study of knowledge exchange

    PubMed Central

    Wye, Lesley; Brangan, Emer; Cameron, Ailsa; Gabbay, John; Klein, Jonathan H; Anthwal, Rachel; Pope, Catherine

    2015-01-01

    Objectives The use of external consultants from private and not-for-profit providers in the National Health Service (NHS) is intended to improve the quality of commissioning. The aim of this study was to learn about the support offered to healthcare commissioners, how external consultants and their clients work together and the perceived impact on the quality of commissioning. Setting NHS commissioning organisations and private and not-for-profit providers. Design Mixed methods case study of eight cases. Data collection 92 interviews with external consultants (n=36), their clients (n=47) and others (n=9). Observation of 25 training events and meetings. Documentation, for example, meeting minutes and reports. Analysis Constant comparison. Data were coded, summarised and analysed by the research team with a coding framework to facilitate cross-case comparison. Results In the four contracts presented here, external providers offered technical solutions (eg, software tools), outsourcing and expertise including project management, data interpretation and brokering relationships with experts. In assessing perceived impact on quality of commissioning, two contracts had limited value, one had short-term benefits and one provided short and longer term benefits. Contracts with commissioners actively learning, embedding and applying new skills were more valued. Other elements of success were: (1) addressing clearly agreed problems of relevance to managerial and operational staff (2) solutions co-produced at all organisational levels (3) external consultants working directly with clients to interpret data outputs to inform locally contextualised commissioning strategies. Without explicit knowledge exchange strategies, outsourcing commissioning to external providers resulted in the NHS clients becoming dependent. Conclusions NHS commissioning will be disadvantaged if commissioners both fail to learn in the short term from the knowledge of external providers and in the longer

  10. American Burn Association Consensus Statements

    DTIC Science & Technology

    2013-08-01

    finally allow us to follow the ACS program in bariatric surgery and link quality-based purchasing with verification. For this col- laborative...University of Washington Medicine Department of Surgery , Seattle, Washington. See under consensus statements for author affiliations. The 2012 ABA burn...correspondence to Nicole S. Gibran MD, FACS, UW Medicine Regional Burn Center, UW Medicine Department of Surgery , Seattle, Washington 98104. Copyright

  11. Writing a PACS program statement.

    PubMed

    Rowe, W M; Moffitt, M E; Bunnell, W J

    1995-01-01

    Medical telecommunications is becoming a necessity for maintaining the quality of care and delivering services on a timely basis in the current environment of cutting services and specialists to reduce costs. (Vanden Brink 1994). Picture archiving and communications systems (PACS) and teleradiology are increasingly viable because there is easier connectivity among modalities and manufacturers. Agreement on the DICOM Standard is one step toward greater connectivity. Two-thirds of the 350 radiology administrators, radiologists, hospital administrators and MIS directors interviewed for the 1994 IMACS/PACS Tracking Study believe that the use of image telecommunication technology is growing. In 1993, Vanderbilt University Medical Center (VUMC) formed a committee to evaluate the need for PACS and to compile a program statement. The principal purpose of the program statement is to provide fundamental information that can be understood easily by individuals outside the radiology department. It outlines the benefits of PACS and includes a financial analysis of the purchase and installation of a system. Key elements of the program statement include a description and analysis of the existing film library system, advantages of PACS, implementation plan, financial proforma and integration with the hospital information system. These and other topics are covered in detail in the following article.

  12. 46 CFR 391.8 - Certain corporate reorganizations and changes in partnerships, and certain transfers on death...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Certain corporate reorganizations and changes in... OF TRANSPORTATION REGULATIONS UNDER PUBLIC LAW 91-469 FEDERAL INCOME TAX ASPECTS OF THE CAPITAL CONSTRUCTION FUND § 391.8 Certain corporate reorganizations and changes in partnerships, and certain...

  13. 26 CFR 1.367(b)-14T - Acquisition of parent stock for property in triangular reorganizations (temporary).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Acquisition of parent stock for property in triangular reorganizations (temporary). 1.367(b)-14T Section 1.367(b)-14T Internal Revenue INTERNAL REVENUE... § 1.367(b)-14T Acquisition of parent stock for property in triangular reorganizations (temporary)....

  14. 26 CFR 1.367(b)-14T - Acquisition of parent stock for property in triangular reorganizations (temporary).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 4 2011-04-01 2011-04-01 false Acquisition of parent stock for property in triangular reorganizations (temporary). 1.367(b)-14T Section 1.367(b)-14T Internal Revenue INTERNAL REVENUE... § 1.367(b)-14T Acquisition of parent stock for property in triangular reorganizations (temporary)....

  15. 76 FR 29724 - Reorganization and Expansion of Foreign-Trade Zone 50 Under Alternative Site Framework; Long...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-23

    ... Framework; Long Beach, CA Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as... general-purpose zones; Whereas, the Board of Harbor Commissioners of the Port of Long Beach, California.../Long Beach U.S. Customs and Border Protection port of entry, FTZ 50's existing Sites 1 through 8,...

  16. 77 FR 41742 - Reorganization and Expansion of Foreign-Trade Zone 202 Under Alternative Site Framework Los...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-16

    ... Framework Los Angeles, CA Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as... general-purpose zones; Whereas, the Board of Harbor Commissioners of the City of Los Angeles, grantee of... Angeles and San Bernardino Counties, California, within and adjacent to the Los Angeles-Long Beach...

  17. Structural damage to the corticospinal tract correlates with bilateral sensorimotor cortex reorganization in stroke patients.

    PubMed

    Schaechter, Judith D; Perdue, Katherine L; Wang, Ruopeng

    2008-02-01

    Damage to the corticospinal tract (CST) in stroke patients has been associated with functional reorganization in the ipsilesional and contralesional sensorimotor cortices. However, it is unknown whether a quantitative relationship exists between the extent of structural damage to the CST and functional reorganization in stroke patients. The purpose of the current study was to examine the relationship between structural CST damage and motor task-related cortical activity in chronic hemiparetic stroke patients. In 10 chronic hemiparetic stroke patients with heterogeneous lesions, CST damage was quantified using conventional structural magnetic resonance imaging and tractography based on diffusion tensor imaging. Cortical activity was measured using functional magnetic resonance imaging during repetitive flexion/extension movements of the digits. We found that the two measures of CST damage were strongly correlated. Moreover, greater CST damage was significantly and linearly correlated with increased activation during affected hand movement in the hand area of the contralesional primary sensorimotor cortex (M1/S1) and in the ipsilesional M1/S1 ventral to the hand area. To our knowledge, this is the first demonstration of a quantitative relationship between the extent of structural damage to the CST and functional reorganization in stroke patients. This relationship was observed in stroke patients with heterogeneous lesions, suggesting that CST damage is a factor relevant to the variation in functional reorganization in the clinical population.

  18. Homotopic Language Reorganization in the Right Hemisphere after Early Left Hemisphere Injury

    ERIC Educational Resources Information Center

    Tivarus, Madalina E.; Starling, Sarah J.; Newport, Elissa L.; Langfitt, John T.

    2012-01-01

    To determine the areas involved in reorganization of language to the right hemisphere after early left hemisphere injury, we compared fMRI activation patterns during four production and comprehension tasks in post-surgical epilepsy patients with either left (LH) or right hemisphere (RH) speech dominance (determined by Wada testing) and healthy…

  19. 26 CFR 1.358-6 - Stock basis in certain triangular reorganizations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... corporation on the exchange of property for the assets or stock of a target corporation in a reorganization... percentage of T stock not acquired in the transaction is determined by taking into account the fair market... aggregate basis of $60 and fair market value of $100 and no liabilities. Pursuant to a plan, P forms S...

  20. Special School Reorganization by a Local Unitary Authority: Some Lessons Learned

    ERIC Educational Resources Information Center

    Ashdown, Rob; Darlington, Chris

    2007-01-01

    This paper reports on the process and outcomes of special school reorganization in one local authority with a particular emphasis upon the implications for those concerned with the education of children with profound and multiple learning difficulties (PMLD). The authors believe that reporting this experience provides pointers for others…

  1. Sleep EEG Changes during Adolescence: An Index of a Fundamental Brain Reorganization

    ERIC Educational Resources Information Center

    Feinberg, Irwin; Campbell, Ian G.

    2010-01-01

    Delta (1-4 Hz) EEG power in non-rapid eye movement (NREM) sleep declines massively during adolescence. This observation stimulated the hypothesis that during adolescence the human brain undergoes an extensive reorganization driven by synaptic elimination. The parallel declines in synaptic density, delta wave amplitude and cortical metabolic rate…

  2. Whose Schools Are They? Principals' Experience of Profound Change during a School Reorganization Process

    ERIC Educational Resources Information Center

    Hanlon, Kathleen P.

    2012-01-01

    Since their inception more than 150 years ago, Catholic schools in the Diocese of Scranton were autonomous, locally managed entities. This completely changed on July 1, 2007 when the schools were reorganized into geographically determined regions, each governed by Central Office. This change replaced local authority over, and responsibility for, a…

  3. Neuroimaging and Neuroenergetics: Brain Activations as Information-Driven Reorganization of Energy Flows

    ERIC Educational Resources Information Center

    Strelnikov, Kuzma

    2010-01-01

    There is increasing focus on the neurophysiological underpinnings of brain activations, giving birth to an emerging branch of neuroscience--neuroenergetics. However, no common definition of "brain activation" exists thus far. In this article, we define brain activation as the information-driven reorganization of energy flows in a population of…

  4. Phantom limb pain, cortical reorganization and the therapeutic effect of mental imagery

    PubMed Central

    Lloyd, D. M.; Kelly, S.; Roberts, N.; Nurmikko, T.

    2008-01-01

    Using functional MRI (fMRI) we investigated 13 upper limb amputees with phantom limb pain (PLP) during hand and lip movement, before and after intensive 6-week training in mental imagery. Prior to training, activation elicited during lip purse showed evidence of cortical reorganization of motor (M1) and somatosensory (S1) cortices, expanding from lip area to hand area, which correlated with pain scores. In addition, during imagined movement of the phantom hand, and executed movement of the intact hand, group maps demonstrated activation not only in bilateral M1 and S1 hand area, but also lip area, showing a two-way process of reorganization. In healthy participants, activation during lip purse and imagined and executed movement of the non-dominant hand was confined to the respective cortical representation areas only. Following training, patients reported a significant reduction in intensity and unpleasantness of constant pain and exacerbations, with a corresponding elimination of cortical reorganization. Post hoc analyses showed that intensity of constant pain, but not exacerbations, correlated with reduction in cortical reorganization. The results of this study add to our current understanding of the pathophysiology of PLP, underlining the reversibility of neuroplastic changes in this patient population while offering a novel, simple method of pain relief. PMID:18567624

  5. Reassessing cortical reorganization in the primary sensorimotor cortex following arm amputation

    PubMed Central

    Scholz, Jan; Henderson Slater, David; Johansen-Berg, Heidi; Tracey, Irene

    2015-01-01

    The role of cortical activity in generating and abolishing chronic pain is increasingly emphasized in the clinical community. Perhaps the most striking example of this is the maladaptive plasticity theory, according to which phantom pain arises from remapping of cortically neighbouring representations (lower face) into the territory of the missing hand following amputation. This theory has been extended to a wide range of chronic pain conditions, such as complex regional pain syndrome. Yet, despite its growing popularity, the evidence to support the maladaptive plasticity theory is largely based on correlations between pain ratings and oftentimes crude measurements of cortical reorganization, with little consideration of potential contributions of other clinical factors, such as adaptive behaviour, in driving the identified brain plasticity. Here, we used a physiologically meaningful measurement of cortical reorganization to reassess its relationship to phantom pain in upper limb amputees. We identified small yet consistent shifts in lip representation contralateral to the missing hand towards, but not invading, the hand area. However, we were unable to identify any statistical relationship between cortical reorganization and phantom sensations or pain either with this measurement or with the traditional Euclidian distance measurement. Instead, we demonstrate that other factors may contribute to the observed remapping. Further research that reassesses more broadly the relationship between cortical reorganization and chronic pain is warranted. PMID:26072517

  6. 75 FR 26198 - Foreign-Trade Zone 152 - Burns Harbor, Indiana, Application for Reorganization under Alternative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-11

    ... Foreign-Trade Zones Board Foreign-Trade Zone 152 - Burns Harbor, Indiana, Application for Reorganization...-purpose zone currently consists of six sites in the Burns Harbor/Gary, Indiana area: Site 1: (533,288 sq...); Site 2: (441 acres) within the Port of Indiana/Burns International Harbor, Burns Harbor (Porter...

  7. Genome reorganization in F1 hybrids uncovers the role of retrotransposons in reproductive isolation

    PubMed Central

    Senerchia, Natacha; Felber, François; Parisod, Christian

    2015-01-01

    Interspecific hybridization leads to new interactions among divergent genomes, revealing the nature of genetic incompatibilities having accumulated during and after the origin of species. Conflicts associated with misregulation of transposable elements (TEs) in hybrids expectedly result in their activation and genome-wide changes that may be key to species boundaries. Repetitive genomes of wild wheats have diverged under differential dynamics of specific long terminal repeat retrotransposons (LTR-RTs), offering unparalleled opportunities to address the underpinnings of plant genome reorganization by selfish sequences. Using reciprocal F1 hybrids between three Aegilops species, restructuring and epigenetic repatterning was assessed at random and LTR-RT sequences with amplified fragment length polymorphism and sequence-specific amplified polymorphisms as well as their methylation-sensitive counterparts, respectively. Asymmetrical reorganization of LTR-RT families predicted to cause conflicting interactions matched differential survival of F1 hybrids. Consistent with the genome shock model, increasing divergence of merged LTR-RTs yielded higher levels of changes in corresponding genome fractions and lead to repeated reorganization of LTR-RT sequences in F1 hybrids. Such non-random reorganization of hybrid genomes is coherent with the necessary repression of incompatible TE loci in support of hybrid viability and indicates that TE-driven genomic conflicts may represent an overlooked factor supporting reproductive isolation. PMID:25716787

  8. 26 CFR 1.1502-30 - Stock basis after certain triangular reorganizations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 12 2010-04-01 2010-04-01 false Stock basis after certain triangular... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Basis, Stock Ownership, and Earnings and Profits Rules § 1.1502-30 Stock basis after certain triangular reorganizations. (a) Scope. This section provides...

  9. Functional MRI Detection of Bilateral Cortical Reorganization in the Rodent Brain Following Peripheral Nerve Deafferentation

    PubMed Central

    Pelled, Galit; Chuang, Kai-Hsiang; Dodd, Stephen J; Koretsky, Alan P

    2007-01-01

    Evidence is emerging for significant inter-hemispheric cortical plasticity in humans, opening important questions about the significance and mechanism for this long range plasticity. In this work, peripheral nerve deafferentation was performed on both the rat forepaw and hindpaw and cortical reorganization was assessed using functional MRI (fMRI). Sensory stimulation of the forepaw or the hindpaw in rats that experienced only partial denervation resulted in activation in only the appropriate, contralateral, primary somatosensory cortex (SI). However, 2-3 weeks following complete denervation of the rats' forepaw or hindpaw, stimulation of the intact paw resulted in fMRI activation of ipsilateral as well as contralateral SI. To address whether inter-cortical communication is required for this cortical reorganization, the healthy hindpaw SI representation was stereotaxically lesioned in rats which had the other hindpaw denervated. No fMRI activation was detected in the ipsilateral SI cortex after lesioning of the contralateral cortex. These results indicate that extensive inter-hemispheric cortical-cortical reorganization can occur in the rodent brain after peripheral nerve deafferentation and that cortical–cortical connections play a role in mediating this inter-hemispheric cortical reorganization. PMID:17544301

  10. 75 FR 17898 - Foreign-Trade Zone 144-Brunswick, GA; Application for Expansion and Reorganization Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Foreign-Trade Zone 144--Brunswick, GA; Application for Expansion and Reorganization Under Alternative Site Framework An application has been submitted to the Foreign-Trade Zones...

  11. Color/Form Matching as Indicator of Cognitive Reorganization in Kindergarten Children

    ERIC Educational Resources Information Center

    Miller, Douglas

    1977-01-01

    It was hypothesized that Piaget's argument on behalf of the reorganization of cognitive processes would gain empirical support from a color/form, matching similar objects problem for 52 6-year-olds from a variety of socioeconomic backgrounds. (Author/MS)

  12. The Reorganization of Basic Science Departments in U.S. Medical Schools, 1980-1999.

    ERIC Educational Resources Information Center

    Mallon, William T.; Biebuyck, Julien F.; Jones, Robert F.

    2003-01-01

    Constructed a longitudinal database to examine how basic science departments have been reorganized at U.S. medical schools. Found that there were fewer basic science departments in the traditional disciplines of anatomy, biochemistry, microbiology, pharmacology, and physiology in 1999 than in 1980. But as biomedical science has developed in an…

  13. 75 FR 24583 - Reorganization/Expansion of Foreign-Trade Zone 21

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Reorganization/Expansion of Foreign-Trade Zone 21 Charleston, South Carolina, Area Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19...

  14. 75 FR 12726 - Expansion/Reorganization of Foreign-Trade Zone 149; Port Freeport, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Expansion/Reorganization of Foreign-Trade Zone 149; Port Freeport, TX Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U.S.C....

  15. 78 FR 30863 - Foreign-Trade Zone 40-Cleveland, Ohio; Application for Reorganization and Expansion Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-23

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Foreign-Trade Zone 40--Cleveland, Ohio; Application for Reorganization and Expansion Under Alternative Site Framework An application has been submitted to the Foreign-Trade Zones...

  16. 76 FR 86 - Expansion/Reorganization of Foreign-Trade Zone 202, Los Angeles, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Expansion/Reorganization of Foreign-Trade Zone 202, Los Angeles, CA Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U.S.C. 81a-81u),...

  17. 77 FR 41373 - Reorganization and Expansion of Foreign-Trade Zone 99 Under Alternative Site Framework...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Reorganization and Expansion of Foreign-Trade Zone 99 Under Alternative Site Framework; Wilmington, DE Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934,...

  18. 76 FR 72673 - Foreign-Trade Zone 33-Pittsburgh, PA; Application for Reorganization/Expansion

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Foreign-Trade Zone 33--Pittsburgh, PA; Application for Reorganization/Expansion An application has been submitted to the Foreign-Trade Zones (FTZ) Board (the Board) by the...

  19. 77 FR 6058 - Expansion/Reorganization of Foreign-Trade Zone 29, Louisville, KY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Expansion/Reorganization of Foreign-Trade Zone 29, Louisville, KY Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U.S.C. 81a-81u),...

  20. 77 FR 69591 - Expansion and Reorganization of Foreign-Trade Zone 33 Pittsburgh, PA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Foreign-Trade Zones Board Expansion and Reorganization of Foreign-Trade Zone 33 Pittsburgh, PA Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U.S.C. 81a-81u),...

  1. 44 CFR 64.4 - Effect on community eligibility resulting from boundary changes, governmental reorganization, etc.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Effect on community... HAZARD MITIGATION National Flood Insurance Program COMMUNITIES ELIGIBLE FOR THE SALE OF INSURANCE § 64.4 Effect on community eligibility resulting from boundary changes, governmental reorganization, etc....

  2. 44 CFR 64.4 - Effect on community eligibility resulting from boundary changes, governmental reorganization, etc.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Effect on community... HAZARD MITIGATION National Flood Insurance Program COMMUNITIES ELIGIBLE FOR THE SALE OF INSURANCE § 64.4 Effect on community eligibility resulting from boundary changes, governmental reorganization, etc....

  3. 44 CFR 64.4 - Effect on community eligibility resulting from boundary changes, governmental reorganization, etc.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Effect on community... HAZARD MITIGATION National Flood Insurance Program COMMUNITIES ELIGIBLE FOR THE SALE OF INSURANCE § 64.4 Effect on community eligibility resulting from boundary changes, governmental reorganization, etc....

  4. 44 CFR 64.4 - Effect on community eligibility resulting from boundary changes, governmental reorganization, etc.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Effect on community... HAZARD MITIGATION National Flood Insurance Program COMMUNITIES ELIGIBLE FOR THE SALE OF INSURANCE § 64.4 Effect on community eligibility resulting from boundary changes, governmental reorganization, etc....

  5. Bilateral Input Protects the Cortex from Unilaterally-Driven Reorganization in Children Who Are Deaf

    ERIC Educational Resources Information Center

    Gordon, Karen A.; Wong, Daniel D. E.; Papsin, Blake C.

    2013-01-01

    Unilateral hearing in childhood restricts input along the bilateral auditory pathways, possibly causing permanent reorganization. In this study we asked: (i) do the auditory pathways develop abnormally in children who are bilaterally deaf and hear with a unilateral cochlear implant? and (ii) can such differences be reversed by restoring input to…

  6. 78 FR 24154 - Notice of Availability of a National Animal Health Laboratory Network Reorganization Concept Paper

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ... Network Reorganization Concept Paper AGENCY: Animal and Plant Health Inspection Service, USDA. ACTION... Plant Health Inspection Service is making available a concept paper that describes a revised structure... paper we are making available for comment presents a structure we believe will give the NAHLN...

  7. Reorganization of the Intact Somatosensory Cortex Immediately after Spinal Cord Injury

    PubMed Central

    Humanes-Valera, Desire; Aguilar, Juan; Foffani, Guglielmo

    2013-01-01

    Sensory deafferentation produces extensive reorganization of the corresponding deafferented cortex. Little is known, however, about the role of the adjacent intact cortex in this reorganization. Here we show that a complete thoracic transection of the spinal cord immediately increases the responses of the intact forepaw cortex to forepaw stimuli (above the level of the lesion) in anesthetized rats. These increased forepaw responses were independent of the global changes in cortical state induced by the spinal cord transection described in our previous work (Aguilar et al., J Neurosci 2010), as the responses increased both when the cortex was in a silent state (down-state) or in an active state (up-state). The increased responses in the intact forepaw cortex correlated with increased responses in the deafferented hindpaw cortex, suggesting that they could represent different points of view of the same immediate state-independent functional reorganization of the primary somatosensory cortex after spinal cord injury. Collectively, the results of the present study and of our previous study suggest that both state-dependent and state-independent mechanisms can jointly contribute to cortical reorganization immediately after spinal cord injury. PMID:23922771

  8. Reorganization of Home Economics in Secondary Schools. Bulletin, 1922, No. 5

    ERIC Educational Resources Information Center

    Bureau of Education, Department of the Interior, 1922

    1922-01-01

    The reorganization of home economics recommended in this report involves important and far reaching changes in both teaching and administration. The committee in home economics distinguishes two types of courses which it designates as general and intensive. To achieve the necessary results in the general courses, teachers must be broadly trained,…

  9. Cortical Development, Plasticity and Re-Organization in Children with Cochlear Implants

    ERIC Educational Resources Information Center

    Sharma, Anu; Nash, Amy A.; Dorman, Michael

    2009-01-01

    A basic tenet of developmental neurobiology is that certain areas of the cortex will re-organize, if appropriate stimulation is withheld for long periods. Stimulation must be delivered to a sensory system within a narrow window of time (a sensitive period) if that system is to develop normally. In this article, we will describe age cut-offs for a…

  10. 77 FR 6059 - Reorganization of Foreign-Trade Zone 124 Under Alternative Site Framework; Gramercy, Louisiana

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... Foreign-Trade Zones Board Reorganization of Foreign-Trade Zone 124 Under Alternative Site Framework..., the Board adopted the alternative site framework (ASF) (74 FR 1170-1173, 01/12/09; correction 74 FR... FTZ 124 under the alternative site framework is approved, subject to the FTZ Act and the...

  11. 76 FR 12937 - Reorganization of Foreign-Trade Zone 46 Under Alternative Site Framework; Cincinnati, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-09

    ... Foreign-Trade Zones Board Reorganization of Foreign-Trade Zone 46 Under Alternative Site Framework... Board adopted the alternative site framework (ASF) (74 FR 1170, 01/12/09; correction 74 FR 3987, 01/22... alternative site framework is approved, subject to the FTZ Act and the Board's regulations, including...

  12. Prospects for Public School Revenues and Local School District Reorganization in Illinois in the 1980s.

    ERIC Educational Resources Information Center

    Geske, Terry G.

    Prospects for Illinois public school revenues and school district reorganization in the 1980's, considered in the context of prospects for the Great Lakes region as a whole, are affected by fundamental demographic and economic changes. The region has had a lower population growth rate since 1970 than the rest of the country, and a slower growth in…

  13. Reorganization and preservation of motor control of the brain in spinal cord injury: a systematic review.

    PubMed

    Kokotilo, Kristen J; Eng, Janice J; Curt, Armin

    2009-11-01

    Reorganization of brain function in people with CNS damage has been identified as one of the fundamental mechanisms involved in the recovery of sensorimotor function. Spinal cord injury (SCI) brain mapping studies during motor tasks aim for assessing the reorganization and preservation of brain networks involved in motor control. Revealing the activation of cortical and subcortical brain areas in people with SCI can indicate principal patterns of brain reorganization when the neurotrauma is distal to the brain. This review assessed brain activation after SCI in terms of intensity, volume, and somatotopic localization, as well as preservation of activation during attempted and/or imagined movements. Twenty-five studies meeting the inclusion criteria could be identified in Medline (1980 to January 2008). Relevant characteristics of studies (level of lesion, time after injury, motor task) and mapping techniques varied widely. Changes in brain activation were found in both cortical and subcortical areas of individuals with SCI. In addition, several studies described a shift in the region of brain activation. These patterns appeared to be dynamic and influenced by the level, completeness, and time after injury, as well as extent of clinical recovery. In addition, several aspects of reorganization of brain function following SCI resembled those reported in stroke. This review demonstrates that brain networks involved in different demands of motor control remain responsive even in chronic paralysis. These findings imply that therapeutic strategies aimed at restoring spinal cord function, even in people with chronic SCI, can build on preserved competent brain control.

  14. Stimulation through Simulation? Motor Imagery and Functional Reorganization in Hemiplegic Stroke Patients

    ERIC Educational Resources Information Center

    Johnson-Frey, Scott H.

    2004-01-01

    A key factor influencing reorganization of function in damaged neural networks of the adult brain is stimulation. How to stimulate motor areas of patients with paralyses is a formidable challenge. One possibility is to use internal movement simulations, or motor imagery, as an alternative to conventional therapeutic interventions that require…

  15. Metric Development During the Reorganization of the Supply Chain Management Center

    DTIC Science & Technology

    2003-12-01

    This MBA Project documents a case study of an ongoing reorganization effort at the Supply Chain Management Center (SCMC), Marine Corps Logistics...Command (MARCORLOGCOM), and their use of the Supply Chain Operations Reference (SCOR) Model and the Balanced Scorecard (BSC) to develop performance

  16. 78 FR 24669 - Reorganization of Regulations on the Adjudication of Department of Homeland Security Practitioner...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-26

    ... Executive Office for Immigration Review 8 CFR Parts 1003 and 1292 RIN 1125-AA66 Reorganization of...: Executive Office for Immigration Review, Department of Justice. ACTION: Final rule. SUMMARY: This final rule... January 13, 2012. The interim rule amended regulations of the Executive Office for Immigration...

  17. Reorganization of Functional Connectivity as a Correlate of Cognitive Recovery in Acquired Brain Injury

    ERIC Educational Resources Information Center

    Castellanos, Nazareth P.; Paul, Nuria; Ordonez, Victoria E.; Demuynck, Olivier; Bajo, Ricardo; Campo, Pablo; Bilbao, Alvaro; Ortiz, Tomas; del-Pozo, Francisco; Maestu, Fernando

    2010-01-01

    Cognitive processes require a functional interaction between specialized multiple, local and remote brain regions. Although these interactions can be strongly altered by an acquired brain injury, brain plasticity allows network reorganization to be principally responsible for recovery. The present work evaluates the impact of brain injury on…

  18. 26 CFR 1.367(b)-9 - Special rule for F reorganizations and similar transactions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 4 2011-04-01 2011-04-01 false Special rule for F reorganizations and similar... following post-1986 undistributed earnings and post-1986 foreign income taxes: Separate Category E&P Foreign... corporation has the following post-1986 undistributed earnings and post-1986 foreign income taxes...

  19. Large impact of reorganization energy on photovoltaic conversion due to interfacial charge-transfer transitions.

    PubMed

    Fujisawa, Jun-ichi

    2015-05-14

    Interfacial charge-transfer (ICT) transitions are expected to be a novel charge-separation mechanism for efficient photovoltaic conversion featuring one-step charge separation without energy loss. Photovoltaic conversion due to ICT transitions has been investigated using several TiO2-organic hybrid materials that show organic-to-inorganic ICT transitions in the visible region. In applications of ICT transitions to photovoltaic conversion, there is a significant problem that rapid carrier recombination is caused by organic-inorganic electronic coupling that is necessary for the ICT transitions. In order to solve this problem, in this work, I have theoretically studied light-to-current conversions due to the ICT transitions on the basis of the Marcus theory with density functional theory (DFT) and time-dependent DFT (TD-DFT) calculations. An apparent correlation between the reported incident photon-to-current conversion efficiencies (IPCE) and calculated reorganization energies was clearly found, in which the IPCE increases with decreasing the reorganization energy consistent with the Marcus theory in the inverted region. This activation-energy dependence was systematically explained by the equation formulated by the Marcus theory based on a simple excited-state kinetic scheme. This result indicates that the reduction of the reorganization energy can suppress the carrier recombination and enhance the IPCE. The reorganization energy is predominantly governed by the structural change in the chemical-adsorption moiety between the ground and ICT excited states. This work provides crucial knowledge for efficient photovoltaic conversion due to ICT transitions.

  20. Processing Systems Optimization Through Automatic Design and Reorganization of Program Modules.

    ERIC Educational Resources Information Center

    Nunamaker, J. F., Jr.; And Others

    A methodology is described for an automatic design system initially defined in terms of logical processes or program modules. Processes and files are grouped and reorganized in such a way as to produce an optimal design with respect to a specific target machine. Performance criteria for the optimal design are defined in terms of transport volume…

  1. 29 CFR 24.114 - District court jurisdiction of retaliation complaints under the Energy Reorganization Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false District court jurisdiction of retaliation complaints under the Energy Reorganization Act. 24.114 Section 24.114 Labor Office of the Secretary of Labor PROCEDURES FOR THE HANDLING OF RETALIATION COMPLAINTS UNDER THE EMPLOYEE PROTECTION PROVISIONS OF SIX ENVIRONMENTAL STATUTES AND SECTION 211 OF THE...

  2. Landscape reorganization under changing climatic forcing: Results from an experimental landscape

    NASA Astrophysics Data System (ADS)

    Singh, Arvind; Reinhardt, Liam; Foufoula-Georgiou, Efi

    2015-06-01

    Understanding how landscapes respond to climate dynamics in terms of macroscale (average topographic features) and microscale (landform reorganization) is of interest both for deciphering past climates from today's landscapes and for predicting future landscapes in view of recent climatic trends. Although several studies have addressed macro-scale response, only a few have focused on quantifying smaller-scale basin reorganization. To that goal, a series of controlled laboratory experiments were conducted where a self-organized complete drainage network emerged under constant precipitation and uplift dynamics. Once steady state was achieved, the landscape was subjected to a fivefold increase in precipitation (transient state). Throughout the evolution, high-resolution spatiotemporal topographic data in the form of digital elevation models were collected. The steady state landscape was shown to possess three distinct geomorphic regimes (unchannelized hillslopes, debris-dominated channels, and fluvially dominated channels). During transient state, landscape reorganization was observed to be driven by hillslopes via accelerated erosion, ridge lowering, channel widening, and reduction of basin relief as opposed to channel base-level reduction. Quantitative metrics on which these conclusions were based included slope-area curve, correlation analysis of spatial and temporal elevation increments, and wavelet spectral analysis of the evolving landscapes. Our results highlight that landscape reorganization in response to increased precipitation seems to follow "an arrow of scale": major elevation change initiates at the hillslope scale driving erosional regime change at intermediate scales and further cascading to geomorphic changes at the channel scale as time evolves.

  3. Cortical Reorganization in Dyslexic Children after Phonological Training: Evidence from Early Evoked Potentials

    ERIC Educational Resources Information Center

    Spironelli, Chiara; Penolazzi, Barbara; Vio, Claudio; Angrilli, Alessandro

    2010-01-01

    Brain plasticity was investigated in 14 Italian children affected by developmental dyslexia after 6 months of phonological training. The means used to measure language reorganization was the recognition potential, an early wave, also called N150, elicited by automatic word recognition. This component peaks over the left temporo-occipital cortex…

  4. Who Wrote the Cardinal Principles Report? The Commission on the Reorganization of Secondary Education Revisited.

    ERIC Educational Resources Information Center

    Wraga, William G.

    This study refutes Edward A. Krug's view of the primary authorship of the document created by the Commission on the Reorganization of Secondary Education in 1918. In general, the commission endorsed cardinal principles that emphasized the practical over the intellectual as well as the importance of social control and social efficiency. The…

  5. Neural network remodeling underlying motor map reorganization induced by rehabilitative training after ischemic stroke.

    PubMed

    Okabe, Naohiko; Shiromoto, Takashi; Himi, Naoyuki; Lu, Feng; Maruyama-Nakamura, Emi; Narita, Kazuhiko; Iwachidou, Nobuhisa; Yagita, Yoshiki; Miyamoto, Osamu

    2016-12-17

    Motor map reorganization is believed to be one mechanism underlying rehabilitation-induced functional recovery. Although the ipsilesional secondary motor area has been known to reorganize motor maps and contribute to rehabilitation-induced functional recovery, it is unknown how the secondary motor area is reorganized by rehabilitative training. In the present study, using skilled forelimb reaching tasks, we investigated neural network remodeling in the rat rostral forelimb area (RFA) of the secondary motor area during 4weeks of rehabilitative training. Following photothrombotic stroke in the caudal forelimb area (CFA), rehabilitative training led to task-specific recovery and motor map reorganization in the RFA. A second injury to the RFA resulted in reappearance of motor deficits. Further, when both the CFA and RFA were destroyed simultaneously, rehabilitative training no longer improved task-specific recovery. In neural tracer studies, although rehabilitative training did not alter neural projection to the RFA from other brain areas, rehabilitative training increased neural projection from the RFA to the lower spinal cord, which innervates the muscles in the forelimb. Double retrograde tracer studies revealed that rehabilitative training increased the neurons projecting from the RFA to both the upper cervical cord, which innervates the muscles in the neck, trunk, and part of the proximal forelimb, and the lower cervical cord. These results suggest that neurons projecting to the upper cervical cord provide new connections to the denervated forelimb area of the spinal cord, and these new connections may contribute to rehabilitation-induced task-specific recovery and motor map reorganization in the secondary motor area.

  6. 48 CFR 35.005 - Work statement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... and creativity. Work statements must be individually tailored by technical and contracting personnel to attain the desired degree of flexibility for contractor creativity and the objectives of the...

  7. 7 CFR 1980.445 - Periodic financial statements and audits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... periodic financial statements to the lender. Lenders must forward copies of the financial statements and the lender's analysis of the statements to the Agency. (a) Audited financial statements. Except as... section shall be considered an impediment to the lender requiring financial statements more......

  8. 45 CFR 1636.3 - Access to written statements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Access to written statements. 1636.3 Section 1636... CLIENT IDENTITY AND STATEMENT OF FACTS § 1636.3 Access to written statements. (a) Written statements of... written statement of facts, either in the lawsuit or through any other procedure. Access to the...

  9. 45 CFR 1636.3 - Access to written statements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Access to written statements. 1636.3 Section 1636... CLIENT IDENTITY AND STATEMENT OF FACTS § 1636.3 Access to written statements. (a) Written statements of... written statement of facts, either in the lawsuit or through any other procedure. Access to the...

  10. 45 CFR 1636.3 - Access to written statements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Access to written statements. 1636.3 Section 1636... CLIENT IDENTITY AND STATEMENT OF FACTS § 1636.3 Access to written statements. (a) Written statements of... written statement of facts, either in the lawsuit or through any other procedure. Access to the...

  11. 45 CFR 1636.3 - Access to written statements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Access to written statements. 1636.3 Section 1636... CLIENT IDENTITY AND STATEMENT OF FACTS § 1636.3 Access to written statements. (a) Written statements of... written statement of facts, either in the lawsuit or through any other procedure. Access to the...

  12. Position Statement On Climate Change.

    PubMed

    2016-05-01

    The North Carolina Environmental Justice Network (NCEJN), a coalition of grassroots organizations, developed a statement to explain our environmental justice perspective on climate change to predominantly white environmental groups that seek to partner with us. NCEJN opposes strategies that reduce greenhouse emissions while maintaining or magnifying existing social, economic, and environmental injustices. Wealthy communities that consume a disproportionate share of resources avoid the most severe consequences of their consumption by displacing pollution on communities of color and low income. Therefore, the success of climate change activism depends on building an inclusive movement based on principles of racial, social and economic justice, and self-determination for all people.

  13. 20 CFR 335.3 - Execution of statement of sickness and supplemental doctor's statement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Execution of statement of sickness and supplemental doctor's statement. 335.3 Section 335.3 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT SICKNESS BENEFITS § 335.3 Execution of statement...

  14. 20 CFR 335.3 - Execution of statement of sickness and supplemental doctor's statement.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Execution of statement of sickness and supplemental doctor's statement. 335.3 Section 335.3 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT SICKNESS BENEFITS § 335.3 Execution of statement...

  15. 20 CFR 335.3 - Execution of statement of sickness and supplemental doctor's statement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Execution of statement of sickness and supplemental doctor's statement. 335.3 Section 335.3 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD UNEMPLOYMENT INSURANCE ACT SICKNESS BENEFITS § 335.3 Execution of statement...

  16. Objectives of Financial Statements. Report of the Study Group on the Objectives of Financial Statements.

    ERIC Educational Resources Information Center

    American Inst. of Certified Public Accountants, New York, NY.

    This report discusses the objectives of financial statements. Emphasis is placed on the function of objectives; users, their goals, and their information needs; the primary enterprise goal and earning power; accountability and financial statements; financial statements--reporting on the goal attainment of business enterprises; financial…

  17. 29 CFR 789.0 - Introductory statement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... assurance.” 1 Pub. L. 718, 75th Cong., 3d sess. (52 Stat. 1060), as amended by the Act of June 26, 1940 (Pub. Res. No. 88, 76th Cong., 3d sess., 54 Stat. 616); by Reorganization Plan No. 2 (60 Stat. 616);...

  18. 29 CFR 789.0 - Introductory statement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... assurance.” 1 Pub. L. 718, 75th Cong., 3d sess. (52 Stat. 1060), as amended by the Act of June 26, 1940 (Pub. Res. No. 88, 76th Cong., 3d sess., 54 Stat. 616); by Reorganization Plan No. 2 (60 Stat. 616);...

  19. 29 CFR 789.0 - Introductory statement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... assurance.” 1 Pub. L. 718, 75th Cong., 3d sess. (52 Stat. 1060), as amended by the Act of June 26, 1940 (Pub. Res. No. 88, 76th Cong., 3d sess., 54 Stat. 616); by Reorganization Plan No. 2 (60 Stat. 616);...

  20. Morphology and histology of chimpanzee primary visual striate cortex indicate that brain reorganization predated brain expansion in early hominid evolution.

    PubMed

    Holloway, Ralph L; Broadfield, Douglas C; Yuan, Michael S

    2003-07-01

    Human brain evolution is characterized by an overall increase in brain size, cerebral reorganization, and cerebral lateralization. It is generally understood when brain enlargement occurred during human evolution. However, issues concerning cerebral reorganization and hemispheric lateralization are more difficult to determine from brain endocasts, and they are topics of considerable debate. One region of the cerebral cortex that may represent the earliest evidence for brain reorganization is the primary visual cortex (PVC), or area 17 of Brodmann. In nonhuman primates, this region is larger in volume (demarcated anteriorly by the lunate sulcus), and extends further rostrally than it does in modern humans. In early hominid fossil (Australopithecus) endocasts, this region appears to occupy a smaller area compared to that in nonhuman primates. Some have argued that the brain first underwent size expansion prior to reorganization, while others maintain that reorganization predated brain expansion. To help resolve this question, we provide a description of two male, common chimpanzee (Pan troglodytes) brains, YN77-111 and YN92-115, which clearly display a more posterior lunate sulcal morphology than seen in other chimpanzees. These data show that neurogenetic variability exists in chimpanzees, and that significant differences in organization (e.g., a reduced PVC) can predate brain enlargement. While the human brain has experienced numerous expansion and reorganization events throughout evolution, the data from these two chimpanzees offer significant support for the hypothesis that the neurogenetic basis for brain reorganization was present in our early fossil ancestors (i.e., the australopithecines) prior to brain enlargement.

  1. Conformational Reorganization Coupled to the Ionization of Internal Lys Residues in Proteins.

    PubMed

    Richman, Daniel E; Majumdar, Ananya; García-Moreno E, Bertrand

    2015-09-29

    Ionizable groups buried in the hydrophobic interior of proteins are essential for energy transduction and catalysis. Because the protein interior is usually neither as polar nor as polarizable as water, these groups tend to have anomalous pKa values, and their ionization tends to be coupled to conformational reorganization. To elucidate mechanisms of energy transduction in proteins, it is necessary to understand the structural determinants of the pKa values of these buried groups, including the range and character of the conformational reorganization that the ionization of these buried groups can elicit. The L25K and L125K variants of staphylococcal nuclease (SNase) were used to characterize the diverse types of structural reorganization that can be promoted by the ionization of buried groups. NMR relaxation dispersion and ZZ-exchange experiments were used to identify the locations and measure the time scales and extent of pH-dependent conformational exchange in these two proteins. The buried Lys-25 and Lys-125 residues titrate with pKa of 6.3 and 6.2, respectively. The L25K protein fluctuates between the native state and an ensemble of locally unfolded states on the 400 μs to 7 ms time scale. On the 100 to 500 ms time scale the native state exchanges with a subglobally unfolded state in which the β-barrel is partially reorganized. The equilibrium between the native state and this alternative state is highly pH dependent; at pH values below the pKa of Lys-25 the state with the partially reorganized β-barrel is the dominant state. In contrast, the L125K protein only exhibited pH-independent fluctuation in the microsecond to millisecond time scale in the region near Lys-125. The study illustrates how diverse and how localized the coupling between conformational reorganization and ionization of buried groups can be. The pH-sensitive exchange between the fully native and subglobally or locally unfolded states in time scales well into hundreds of milliseconds will

  2. Visual Cross-Modal Re-Organization in Children with Cochlear Implants

    PubMed Central

    2016-01-01

    Background Visual cross-modal re-organization is a neurophysiological process that occurs in deafness. The intact sensory modality of vision recruits cortical areas from the deprived sensory modality of audition. Such compensatory plasticity is documented in deaf adults and animals, and is related to deficits in speech perception performance in cochlear-implanted adults. However, it is unclear whether visual cross-modal re-organization takes place in cochlear-implanted children and whether it may be a source of variability contributing to speech and language outcomes. Thus, the aim of this study was to determine if visual cross-modal re-organization occurs in cochlear-implanted children, and whether it is related to deficits in speech perception performance. Methods Visual evoked potentials (VEPs) were recorded via high-density EEG in 41 normal hearing children and 14 cochlear-implanted children, aged 5–15 years, in response to apparent motion and form change. Comparisons of VEP amplitude and latency, as well as source localization results, were conducted between the groups in order to view evidence of visual cross-modal re-organization. Finally, speech perception in background noise performance was correlated to the visual response in the implanted children. Results Distinct VEP morphological patterns were observed in both the normal hearing and cochlear-implanted children. However, the cochlear-implanted children demonstrated larger VEP amplitudes and earlier latency, concurrent with activation of right temporal cortex including auditory regions, suggestive of visual cross-modal re-organization. The VEP N1 latency was negatively related to speech perception in background noise for children with cochlear implants. Conclusion Our results are among the first to describe cross modal re-organization of auditory cortex by the visual modality in deaf children fitted with cochlear implants. Our findings suggest that, as a group, children with cochlear implants show

  3. 40 CFR 156.212 - Personal protective equipment statements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) PESTICIDE PROGRAMS LABELING REQUIREMENTS FOR PESTICIDES AND DEVICES Worker Protection Statements § 156.212... equipment statements—(1) Personal protective equipment statements for pesticide handlers. Personal protective equipment statements for pesticide handlers shall be in the HAZARDS TO HUMANS (AND...

  4. Position Statement on Active Outdoor Play

    PubMed Central

    Tremblay, Mark S.; Gray, Casey; Babcock, Shawna; Barnes, Joel; Costas Bradstreet, Christa; Carr, Dawn; Chabot, Guylaine; Choquette, Louise; Chorney, David; Collyer, Cam; Herrington, Susan; Janson, Katherine; Janssen, Ian; Larouche, Richard; Pickett, William; Power, Marlene; Sandseter, Ellen Beate Hansen; Simon, Brenda; Brussoni, Mariana

    2015-01-01

    A diverse, cross-sectorial group of partners, stakeholders and researchers, collaborated to develop an evidence-informed Position Statement on active outdoor play for children aged 3–12 years. The Position Statement was created in response to practitioner, academic, legal, insurance and public debate, dialogue and disagreement on the relative benefits and harms of active (including risky) outdoor play. The Position Statement development process was informed by two systematic reviews, a critical appraisal of the current literature and existing position statements, engagement of research experts (N = 9) and cross-sectorial individuals/organizations (N = 17), and an extensive stakeholder consultation process (N = 1908). More than 95% of the stakeholders consulted strongly agreed or somewhat agreed with the Position Statement; 14/17 participating individuals/organizations endorsed it; and over 1000 additional individuals and organizations requested their name be listed as a supporter. The final Position Statement on Active Outdoor Play states: “Access to active play in nature and outdoors—with its risks— is essential for healthy child development. We recommend increasing children’s opportunities for self-directed play outdoors in all settings—at home, at school, in child care, the community and nature.” The full Position Statement provides context for the statement, evidence supporting it, and a series of recommendations to increase active outdoor play opportunities to promote healthy child development. PMID:26062040

  5. 14 CFR 313.6 - Energy statements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Energy statements. 313.6 Section 313.6... REGULATIONS IMPLEMENTATION OF THE ENERGY POLICY AND CONSERVATION ACT § 313.6 Energy statements. (a) Each major... action taken or to be taken upon energy efficiency and conservation. The administrative law judge or...

  6. 14 CFR 313.6 - Energy statements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Energy statements. 313.6 Section 313.6... REGULATIONS IMPLEMENTATION OF THE ENERGY POLICY AND CONSERVATION ACT § 313.6 Energy statements. (a) Each major... action taken or to be taken upon energy efficiency and conservation. The administrative law judge or...

  7. 48 CFR 35.005 - Work statement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... work statements, contracting officers should ensure that language suitable for a level-of-effort... intermingled with language suitable for a task-completion approach, which often requires the development of a... and form of contract contemplated by the Government and, for level-of-effort work statements,...

  8. 7 CFR 1580.101 - General statement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false General statement. 1580.101 Section 1580.101 Agriculture Regulations of the Department of Agriculture (Continued) FOREIGN AGRICULTURAL SERVICE, DEPARTMENT OF AGRICULTURE TRADE ADJUSTMENT ASSISTANCE FOR FARMERS § 1580.101 General statement. This...

  9. Students' Interpretations of Mathematical Statements Involving Quantification

    ERIC Educational Resources Information Center

    Piatek-Jimenez, Katrina

    2010-01-01

    Mathematical statements involving both universal and existential quantifiers occur frequently in advanced mathematics. Despite their prevalence, mathematics students often have difficulties interpreting and proving quantified statements. Through task-based interviews, this study took a qualitative look at undergraduate mathematics students'…

  10. 29 CFR 570.101 - Introductory statement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS CHILD LABOR REGULATIONS, ORDERS AND STATEMENTS OF INTERPRETATION General Statements of Interpretation of the Child Labor...) This subpart discusses the meaning and scope of the child labor provisions contained in the Fair...

  11. 29 CFR 570.101 - Introductory statement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS CHILD LABOR REGULATIONS, ORDERS AND STATEMENTS OF INTERPRETATION General Statements of Interpretation of the Child Labor...) This subpart discusses the meaning and scope of the child labor provisions contained in the Fair...

  12. 29 CFR 570.101 - Introductory statement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS CHILD LABOR REGULATIONS, ORDERS AND STATEMENTS OF INTERPRETATION General Statements of Interpretation of the Child Labor...) This subpart discusses the meaning and scope of the child labor provisions contained in the Fair...

  13. 29 CFR 570.101 - Introductory statement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS CHILD LABOR REGULATIONS, ORDERS AND STATEMENTS OF INTERPRETATION General Statements of Interpretation of the Child Labor...) This subpart discusses the meaning and scope of the child labor provisions contained in the Fair...

  14. 29 CFR 570.101 - Introductory statement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS CHILD LABOR REGULATIONS, ORDERS AND STATEMENTS OF INTERPRETATION General Statements of Interpretation of the Child Labor...) This subpart discusses the meaning and scope of the child labor provisions contained in the Fair...

  15. A Typology of Statements about Discourse

    ERIC Educational Resources Information Center

    Pallotti, Gabriele

    2016-01-01

    The article presents a typology of statements that can be made about discourse data. The classification is based on two parameters: level of generality and level of interpretation. Each of these is operationalized into three discrete levels, to yield a nine-cell table containing types of statements going from the presentation of a single case to…

  16. 78 FR 48672 - Environmental Impacts Statements;

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Environmental Impacts Statements; Notice of Availability Responsible Agency: Office of Federal... Environmental Impact Statements Filed 07/29/2013 Through 08/02/2013 Pursuant to 40 CFR 1506.9. Notice...

  17. 47 CFR 76.1801 - Registration statement.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 4 2014-10-01 2014-10-01 false Registration statement. 76.1801 Section 76.1801... CABLE TELEVISION SERVICE Reports and Filings § 76.1801 Registration statement. (a) A system community... signals to be carried which previously have not been certified or registered; and (7) The FCC...

  18. 47 CFR 76.1801 - Registration statement.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Registration statement. 76.1801 Section 76.1801... CABLE TELEVISION SERVICE Reports and Filings § 76.1801 Registration statement. (a) A system community... signals to be carried which previously have not been certified or registered; and (7) The FCC...

  19. 49 CFR 107.503 - Registration statement.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Registration statement. 107.503 Section 107.503... PROGRAM PROCEDURES Registration of Cargo Tank and Cargo Tank Motor Vehicle Manufacturers, Assemblers, Repairers, Inspectors, Testers, and Design Certifying Engineers § 107.503 Registration statement. (a)...

  20. 47 CFR 76.1801 - Registration statement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Registration statement. 76.1801 Section 76.1801... CABLE TELEVISION SERVICE Reports and Filings § 76.1801 Registration statement. (a) A system community... signals to be carried which previously have not been certified or registered; and (7) The FCC...