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Sample records for commissioner reorganization statement

  1. 75 FR 7490 - Office of the Commissioner Reorganization; Statement of Organizations, Functions, and Delegations...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ... Good Clinical Practice (formerly titled the Good Clinical Practice Program) which all will be realigned... leadership to the Office of Good Clinical Practice. 5. Oversees the functions of the Office of Combination..., departmental policies, and related regulations and statutes. Office of Good Clinical Practice: 1. Advises and...

  2. Reorganized text.

    PubMed

    2015-05-01

    Reorganized Text: In the Original Investigation titled “Patterns of Hospital Utilization for Head and Neck Cancer Care: Changing Demographics” posted online in the January 29, 2015, issue of JAMA Otolaryngology–Head & Neck Surgery (doi:10.1001 /jamaoto.2014.3603), information was copied within sections and text rearranged to accommodate Continuing Medical Education quiz formatting. The information from the topic statements of each paragraph in the Hypothesis Testing subsection of the Methods section was collected in a new first paragraph for that subsection, which reads as follows: “Several hypotheses regarding the causes of regionalization of HNCA care were tested using the NIS data: (1) increasing patient comorbidities over time, causing a shift in care to teaching institutions that would theoretically be better equipped to handle such increased comorbidities; (2) shifting of payer status; (3) increased proportion of prior radiation therapy; and (4) a higher fraction of more complex procedures being referred and performed at teaching institutions.” In addition, the phrase "As summarized in Table3," was added to the beginning of paragraph 6 of the Discussion section, and the call-out to Table 3 in the middle of that paragraph was deleted. Finally, paragraphs 6 and 7 of the Discussion section were combined.

  3. Concurring Statement In Re: Children's Television Report.

    ERIC Educational Resources Information Center

    Hooks, Benjamin L.

    1974-01-01

    Three Federal Communications Commissioners (FCC) filed supplementary statements to the FCC Children's Television Report, elaborating on their individual views. Commissioner Benjamin L. Hooks concurred in the proposed limit on commercial minutes in children's programs, but suggested a lower figure. He also suggested that commercials be…

  4. 47 CFR 0.218 - Authority of, and delegated to, an individual Commissioner or Commissioners.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Authority of, and delegated to, an individual Commissioner or Commissioners. 0.218 Section 0.218 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Delegations of Authority Commissioners § 0.218 Authority of, and delegated to, an...

  5. 7 CFR 97.301 - Commissioner's answer.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Commissioner's answer. 97.301 Section 97.301... PLANT VARIETY AND PROTECTION Appeal to the Secretary § 97.301 Commissioner's answer. (a) The... Secretary in answer to the appellant's petition, including such explanation of the reasons for the action as...

  6. 47 CFR 0.381 - Defense Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Defense Commissioner. 0.381 Section 0.381... National Security and Emergency Preparedness Delegations § 0.381 Defense Commissioner. The authority delegated to the Commission under Executive Orders 12472 and 12656 is redelegated to the Defense...

  7. 47 CFR 0.381 - Defense Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Defense Commissioner. 0.381 Section 0.381... National Security and Emergency Preparedness Delegations § 0.381 Defense Commissioner. The authority delegated to the Commission under Executive Orders 12472 and 12656 is redelegated to the Defense...

  8. The Leadership Proficiency of Commissioners of Agriculture

    ERIC Educational Resources Information Center

    Baughman, Kristen N.; Bruce, Jacklyn

    2012-01-01

    The purpose of this mixed methods study was to determine the self-perceived proficiency level of Commissioners of Agriculture in six leadership skill areas. Major findings noted their proficiency in these areas. Researchers recommend providing professional development opportunities and software training for Commissioners at their annual…

  9. 47 CFR 0.381 - Defense Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Defense Commissioner. 0.381 Section 0.381... National Security and Emergency Preparedness Delegations § 0.381 Defense Commissioner. The authority delegated to the Commission under Executive Orders 12472 and 12656 is redelegated to the...

  10. 47 CFR 0.381 - Defense Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Defense Commissioner. 0.381 Section 0.381... National Security and Emergency Preparedness Delegations § 0.381 Defense Commissioner. The authority delegated to the Commission under Executive Orders 12472 and 12656 is redelegated to the...

  11. 47 CFR 0.381 - Defense Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Defense Commissioner. 0.381 Section 0.381... National Security and Emergency Preparedness Delegations § 0.381 Defense Commissioner. The authority delegated to the Commission under Executive Orders 12472 and 12656 is redelegated to the...

  12. The Leadership Proficiency of Commissioners of Agriculture

    ERIC Educational Resources Information Center

    Baughman, Kristen N.; Bruce, Jacklyn

    2012-01-01

    The purpose of this mixed methods study was to determine the self-perceived proficiency level of Commissioners of Agriculture in six leadership skill areas. Major findings noted their proficiency in these areas. Researchers recommend providing professional development opportunities and software training for Commissioners at their annual…

  13. Drilling reorganizes

    NASA Astrophysics Data System (ADS)

    Richman, Barbara T.

    As the first in a proposed series of steps that would move scientific ocean drilling from its own niche within the National Science Foundation's (NSF) Directorate for Astronomical, Atmospheric, Earth, and Ocean Sciences (AAEO) into the agency's Division of Ocean Sciences, Grant Gross, division director, has been appointed acting director of the Office of Scientific Ocean Drilling (OSOD). Gross will retain the directorship of the division, which also is part of AAEO. Allen M. Shinn, Jr., OSOD director for nearly 2 years, has been reassigned effective July 10 to a position in NSF's Office of Planning and Resource Management.The move aims to tie drilling operations more closely to the science with which it is associated, Gross said. This first step is an organizational response to the current leaning toward using a commercial drilling vessel as the drilling platform, he said. Before the market for such commercial drill ships opened (Eos, February 22, 1983, p . 73), other ship options for scientific ocean drilling included refurbishing the aging Glomar Challenger or renovating, at great expense, the Glomar Explorer. A possible next step in the reorganization is to make OSOD the third section within the Ocean Sciences Division. Currently, the division is divided into the Oceanographic Facilities and Support Section and the Ocean Sciences Research Section.

  14. School District Reorganization: Can Small Schools Compete? A Position Paper.

    ERIC Educational Resources Information Center

    Mack, David P.; Lederman, Alfred T.

    The following position statements regarding school reorganization are discussed in chapter-by-chapter sequence within the paper: (1) It is the responsibility of all schools, regardless of size, to prepare students adequately to live full and productive lives in a rapidly changing world. (2) In New York State, school district reorganization, while…

  15. Wind Energy Guide for County Commissioners

    EPA Pesticide Factsheets

    This report provides county commissioners, planners, and other local county government officials with a practical overview of information required to successfully implement commercial wind energy projects in their county.

  16. Public policy involvement by health commissioners.

    PubMed

    Thompson, Amy; Boardley, Debra; Kerr, Dianne; Greene, Tiffany; Jenkins, Melissa

    2009-08-01

    The purpose of this national study was to determine advocacy activities and level of involvement of health commissioners regarding public policy. Benefits, barriers, and perceived outcomes of advocacy efforts were also explored. A previously validated (Holtrop et al., Am J Health Behav 24(2):132-142, 2000) four-page survey was mailed to 700 health commissioners, who were randomly selected from the National Association of County and City Health Officials (NACCHO) database. A three-wave mailing was performed which yielded a 50% response rate. Of these respondents, the majority (70%) were female and (88%) Caucasian. Overall, 31% of health commissioners reported being involved in influencing public policy in the last 4 years. The most common reported activities engaged in by health commissioners included voting (84%), and providing policy information to consumers or other professionals (77%). Perceived barriers to influencing policy were time, (64%), and other priorities (46%). Perceived benefits to influencing policy included improving the health of the public (94%) and making a difference in others' lives (87%). Only 15% perceived their knowledge regarding the process of changing public policy was excellent. Although health commissioners are often spokespersons for health agencies and communities, their public policy involvement is marginal. Professional preparation programs and continuing education opportunities should focus on advocacy, public policy development, and removing barriers to action.

  17. Assessing New York's Commissioner of Education

    ERIC Educational Resources Information Center

    Meyer, Peter

    2011-01-01

    In this article, the author talks about the resignation of New York State's commissioner of education David Steiner, and how it will affect the state's Race to the Top. He contends that Steiner was savvy enough to understand the importance of Race to the Top and able enough to turn the state's education energies toward it. The "Washington…

  18. Assessing New York's Commissioner of Education

    ERIC Educational Resources Information Center

    Meyer, Peter

    2011-01-01

    In this article, the author talks about the resignation of New York State's commissioner of education David Steiner, and how it will affect the state's Race to the Top. He contends that Steiner was savvy enough to understand the importance of Race to the Top and able enough to turn the state's education energies toward it. The "Washington…

  19. 19 CFR 111.57 - Determination by Assistant Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Determination by Assistant Commissioner. 111.57... Monetary Penalty in Lieu of Suspension or Revocation § 111.57 Determination by Assistant Commissioner. The Assistant Commissioner will make a determination on whether or not charges should be preferred, and he will...

  20. 77 FR 8804 - Foreign-Trade Zone 202-Los Angeles, CA; Application for Reorganization and Expansion Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... Foreign-Trade Zones Board Foreign-Trade Zone 202--Los Angeles, CA; Application for Reorganization and...) Board (the Board) by the Board of Harbor Commissioners of the City of Los Angeles, grantee of FTZ 202... Angeles, San Bernardino and Riverside Counties as follows: Site 1 (2,775 acres total)--Port of Los Angeles...

  1. Data Reorganization Interface

    DTIC Science & Technology

    2007-11-02

    Data Reorganization Interface Kenneth Cain Mercury Computer Systems, Inc. Phone: (978)-967-1645 Email Address: kcain@mc.com Abstract...6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Mercury Computer Systems...18 © 2003 Mercury Computer Systems, Inc. Data Reorganization Interface (DRI) Kenneth Cain Jr. Mercury Computer Systems, Inc. High Performance

  2. 21 CFR 201.309 - Acetophenetidin (phenacetin)-containing preparations; necessary warning statement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... of the drug were in fact responsible for kidney lesions and disease. The Commissioner of Food and... statement to the following effect: “Warning—This medication may damage the kidneys when used in large...

  3. 21 CFR 201.309 - Acetophenetidin (phenacetin)-containing preparations; necessary warning statement.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... of the drug were in fact responsible for kidney lesions and disease. The Commissioner of Food and... statement to the following effect: “Warning—This medication may damage the kidneys when used in large...

  4. 21 CFR 201.309 - Acetophenetidin (phenacetin)-containing preparations; necessary warning statement.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... of the drug were in fact responsible for kidney lesions and disease. The Commissioner of Food and... statement to the following effect: “Warning—This medication may damage the kidneys when used in large...

  5. 21 CFR 201.309 - Acetophenetidin (phenacetin)-containing preparations; necessary warning statement.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... of the drug were in fact responsible for kidney lesions and disease. The Commissioner of Food and... statement to the following effect: “Warning—This medication may damage the kidneys when used in large...

  6. 16 CFR 802.10 - Stock dividends and splits; reorganizations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Stock dividends and splits; reorganizations. 802.10 Section 802.10 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 EXEMPTION RULES § 802.10...

  7. 16 CFR 802.10 - Stock dividends and splits; reorganizations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Stock dividends and splits; reorganizations. 802.10 Section 802.10 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 EXEMPTION RULES § 802.10...

  8. 16 CFR 802.10 - Stock dividends and splits; reorganizations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Stock dividends and splits; reorganizations. 802.10 Section 802.10 Commercial Practices FEDERAL TRADE COMMISSION RULES, REGULATIONS, STATEMENTS AND INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 EXEMPTION RULES § 802.10...

  9. 24 CFR 207.257 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Commissioner's right to require acceleration. 207.257 Section 207.257 Housing and Urban Development Regulations Relating to Housing and Urban... Mortgagee Under the Contract of Insurance § 207.257 Commissioner's right to require acceleration....

  10. 24 CFR 232.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Commissioner's right to require acceleration. 232.860 Section 232.860 Housing and Urban Development Regulations Relating to Housing and Urban... of Insurance § 232.860 Commissioner's right to require acceleration. Upon receipt of notice of...

  11. 24 CFR 232.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Commissioner's right to require acceleration. 232.860 Section 232.860 Housing and Urban Development Regulations Relating to Housing and Urban... of Insurance § 232.860 Commissioner's right to require acceleration. Upon receipt of notice of...

  12. 24 CFR 241.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Commissioner's right to require acceleration. 241.860 Section 241.860 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance § 241.860 Commissioner's right to require acceleration. Upon receipt of notice of the failure...

  13. 24 CFR 241.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Commissioner's right to require acceleration. 241.860 Section 241.860 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance § 241.860 Commissioner's right to require acceleration. Upon receipt of notice of the failure...

  14. 24 CFR 241.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Commissioner's right to require acceleration. 241.860 Section 241.860 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance § 241.860 Commissioner's right to require acceleration. Upon receipt of notice of the failure...

  15. 24 CFR 232.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Commissioner's right to require acceleration. 232.860 Section 232.860 Housing and Urban Development Regulations Relating to Housing and Urban... of Insurance § 232.860 Commissioner's right to require acceleration. Upon receipt of notice of...

  16. 24 CFR 232.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Commissioner's right to require acceleration. 232.860 Section 232.860 Housing and Urban Development Regulations Relating to Housing and Urban... of Insurance § 232.860 Commissioner's right to require acceleration. Upon receipt of notice of...

  17. 24 CFR 241.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Commissioner's right to require acceleration. 241.860 Section 241.860 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance § 241.860 Commissioner's right to require acceleration. Upon receipt of notice of the failure...

  18. 24 CFR 232.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Commissioner's right to require acceleration. 232.860 Section 232.860 Housing and Urban Development Regulations Relating to Housing and Urban... of Insurance § 232.860 Commissioner's right to require acceleration. Upon receipt of notice of...

  19. 24 CFR 241.860 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Commissioner's right to require acceleration. 241.860 Section 241.860 Housing and Urban Development Regulations Relating to Housing and Urban... Insurance § 241.860 Commissioner's right to require acceleration. Upon receipt of notice of the failure...

  20. 20 CFR 498.222 - Final decision of the Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Final decision of the Commissioner. 498.222 Section 498.222 Employees' Benefits SOCIAL SECURITY ADMINISTRATION CIVIL MONETARY PENALTIES, ASSESSMENTS AND RECOMMENDED EXCLUSIONS § 498.222 Final decision of the Commissioner. (a) Except with respect...

  1. Unions and Workplace Reorganization.

    ERIC Educational Resources Information Center

    Nissen, Bruce, Ed.

    The 11 chapters in this book focus on "The New American Workplace" and assess its adequacy or inadequacy as a guide for the U.S. labor movement in relation to new work systems. "Unions and Workplace Reorganization" (Bruce Nissen) introduces the subject. "The New American Workplace: A Labor Perspective" (AFL-CIO Committee on the Evolution of Work,…

  2. BIA Reorganization Task Force

    ERIC Educational Resources Information Center

    American Indian Journal, 1978

    1978-01-01

    Reporting on three hearings held this spring by the Bureau of Indian Affairs Reorganization Task Force, this article presents highlights from the testimony of Forrest Gerard, Assistant Secretary for Indian Affairs and discusses the matrix system of organization currently under consideration by the BIA. (JC)

  3. Unions and Workplace Reorganization.

    ERIC Educational Resources Information Center

    Nissen, Bruce, Ed.

    The 11 chapters in this book focus on "The New American Workplace" and assess its adequacy or inadequacy as a guide for the U.S. labor movement in relation to new work systems. "Unions and Workplace Reorganization" (Bruce Nissen) introduces the subject. "The New American Workplace: A Labor Perspective" (AFL-CIO Committee on the Evolution of Work,…

  4. THE MYTHS OF REORGANIZATION.

    ERIC Educational Resources Information Center

    DEGOOD, K.C.

    A GROUP OF MORE THAN 80 BUSINESSMEN AND INDUSTRIAL LEADERS (LITTLE HOOVER COMMISSION) CONDUCTED A STUDY OF OHIO SCHOOL DISTRICTS AND RECOMMENDED ACCELERATED REORGANIZATION AND CONSOLIDATION AS A MEANS OF IMPROVING EDUCATIONAL QUALITY. IN ORDER TO IMPLEMENT THE COMMISSION'S RECOMMENDATIONS, HOWEVER, IT WILL BE NECESSARY TO DISPEL SEVERAL MYTHS. THE…

  5. Wind Energy Guide for County Commissioners

    SciTech Connect

    Costanti, M.

    2006-10-01

    One of the key stakeholders associated with economic development are local government officials, who are often required to evaluate and vote on commercial wind energy project permits, as well as to determine and articulate what wind energy benefits accrue to their counties. Often these local officials lack experience with large-scale wind energy and need to make important decisions concerning what may be a complicated and controversial issue. These decisions can be confounded with diverse perspectives from various stakeholders. This project is designed to provide county commissioners, planners, and other local county government officials with a practical overview of information required to successfully implement commercial wind energy projects in their county. The guidebook provides readers with information on the following 13 topics: Brief Wind Energy Overview; Environmental Benefits; Wind Energy Myths and Facts; Economic Development Benefits; Wind Economics; The Development Process; Public Outreach; Siting Issues; Property Tax Incentives; Power System Impacts; Permitting, Zoning, and Siting Processes; Case Studies; and Further Information. For each of the above topics, the guidebook provides an introduction that identifies the topic, why local government should care, a topic snapshot, how the topic will arise, and a list of resources that define and assess the topic.

  6. 47 CFR 0.181 - The Defense Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... designated by the Commission. The Defense Commissioner directs the homeland security, national security and... in public safety, homeland security, national security, emergency preparedness, disaster management... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Organization Homeland Security...

  7. 47 CFR 0.181 - The Defense Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... designated by the Commission. The Defense Commissioner directs the homeland security, national security and... in public safety, homeland security, national security, emergency preparedness, disaster management... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Organization Homeland Security...

  8. SITE DEMONSTRATION OF THE TORONTO HARBOUR COMMISSIONERS SOIL RECYCLING PROJECT

    EPA Science Inventory

    The U.S. Environmental Protection Agency (EPA), in cooperation with the Toronto Harbour Commissioners (THC), conducted a Superfund InnovativeTechnology Evaluation (SITE) demonstration of the THC Soil Recycle Treatment Train. The treatment train consists of three technologies op...

  9. SITE DEMONSTRATION OF THE TORONTO HARBOUR COMMISSIONERS SOIL RECYCLING PROJECT

    EPA Science Inventory

    The U.S. Environmental Protection Agency (EPA), in cooperation with the Toronto Harbour Commissioners (THC), conducted a Superfund InnovativeTechnology Evaluation (SITE) demonstration of the THC Soil Recycle Treatment Train. The treatment train consists of three technologies op...

  10. 45 CFR 1321.31 - Appeal to Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.31 Appeal to Commissioner. This...

  11. 45 CFR 1321.31 - Appeal to Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.31 Appeal to Commissioner. This...

  12. 45 CFR 1321.31 - Appeal to Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.31 Appeal to Commissioner. This...

  13. 45 CFR 1321.31 - Appeal to Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.31 Appeal to Commissioner. This...

  14. 45 CFR 1321.31 - Appeal to Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., DEPARTMENT OF HEALTH AND HUMAN SERVICES THE ADMINISTRATION ON AGING, OLDER AMERICANS PROGRAMS GRANTS TO STATE AND COMMUNITY PROGRAMS ON AGING State Agency Responsibilities § 1321.31 Appeal to Commissioner. This...

  15. Leadership and Managerial Skills of County Commissioners as Perceived by County Commissioners, Ohio State University Extension Chairs and Assessment Center Assessors.

    ERIC Educational Resources Information Center

    Rinehart, Susan Hodson; Smith, Keith

    1994-01-01

    The performance of 16 Ohio county commissioners in an assessment center simulation was rated by themselves and 6 center evaluators. Real-life performance was rated by the commissioners and 15 county extension chairs. Commissioners' performance in the simulation was rated well above average by evaluators, and chairs rated real-life performance even…

  16. 78 FR 69704 - 60-Day Notice of Proposed Information Collection: HUD Conditional Commitment/Statement of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-20

    ... of Appraised Value AGENCY: Office of the Assistant Secretary for Housing-Federal Housing Commissioner... Conditional Commitment/Direct Endorsement Statement of Appraised Value. OMB Approval Number: 2502-0494. Type... mortgagee's conditional commitment/direct endorsement statement of value of FHA mortgage insurance on the...

  17. 24 CFR 200.931 - Statement of availability.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Statement of availability. 200.931 Section 200.931 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND...

  18. 75 FR 43963 - Notice of Commissioner and Staff Attendance at National Association of Regulatory Utility...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Commissioner and Staff Attendance at National Association of Regulatory Utility Commissioners Summer Committee Meetings July 20, 2010. The Federal Energy Regulatory...

  19. 78 FR 7772 - Notice of Commissioner and Staff Attendance at National Association of Regulatory Utility...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Commissioner and Staff Attendance at National Association of... following meeting: FERC/National Association of Regulatory Utility Commissioners Sunday Morning...

  20. 76 FR 71006 - Notice of Commissioner and Staff Attendance at National Association of Regulatory Utility...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Commissioner and Staff Attendance at National Association of... following meeting: FERC/National Association of Regulatory Utility Commissioners Collaborative, on Smart...

  1. 19 CFR 12.42 - Findings of Commissioner of Customs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Labor § 12.42 Findings of Commissioner of Customs. (a) If any port director or other principal Customs... foreign locality with the use of convict labor, forced labor, or indentured labor under penal sanctions, including forced child labor or indentured child labor under penal sanctions, so as to come within...

  2. Navajo Health Authority, Board of Commissioners, Annual Report, June 1977.

    ERIC Educational Resources Information Center

    Navajo Health Authority, Window Rock, AZ.

    Major developments for the Navajo Health Authority (NHA) and the new American Indian School of Medicine (AISOM) during 1976-77 are highlighted in this fifth annual report by NHA commissioners. Developments cited include renovation of the Shiprock Community Center for use by AISOM, last year of funding from the Area Health Education Center…

  3. 19 CFR 115.17 - Appeal to Commissioner of Customs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Appeal to Commissioner of Customs. 115.17 Section 115.17 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL...

  4. 4. DETAIL OF BUILDER'S PLATES: '1901, CARTER H. HARRISON, COMMISSIONER ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. DETAIL OF BUILDER'S PLATES: '1901, CARTER H. HARRISON, COMMISSIONER OF PUBLIC WORKS, MAYOR F.W. BLOCKI, JOHN ERICSON, CITY ENGINEER'; 'FITZSIMONS AND CONNELL CO. SUBSTRUCTURE'; 'AMERICAN BRIDGE COMPANY, LASSIG PLANT, CONTRACTOR FOR SUPERSTRUCTURE' - Chicago River Bascule Bridge, West Cortland Street, Spanning North Branch of Chicago River at West Cortland Street, Chicago, Cook County, IL

  5. FCC Commissioner, Legal Assistant and Staff Perceptions of Cable TV.

    ERIC Educational Resources Information Center

    Krugman, Dean M.

    1979-01-01

    Describes a methodology used in interviewing Federal Communications Commission commissioners, legal assistants, and Cable Bureau staff members about their attitudes toward the cable industry and regulation; reports results of the interviews, noting respondents' disappointment in the lack of cable growth. (GT)

  6. 24 CFR 207.257 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Commissioner's right to require acceleration. 207.257 Section 207.257 Housing and Urban Development Regulations Relating to Housing and...

  7. 24 CFR 207.257 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Commissioner's right to require acceleration. 207.257 Section 207.257 Housing and Urban Development Regulations Relating to Housing and...

  8. 24 CFR 207.257 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Commissioner's right to require acceleration. 207.257 Section 207.257 Housing and Urban Development Regulations Relating to Housing and...

  9. 24 CFR 207.257 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Commissioner's right to require acceleration. 207.257 Section 207.257 Housing and Urban Development Regulations Relating to Housing and...

  10. 24 CFR 220.813 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Commissioner's right to require acceleration. 220.813 Section 220.813 Housing and Urban Development Regulations Relating to Housing and Urban...'s right to require acceleration. Upon receipt of notice of the failure of the borrower to comply...

  11. 24 CFR 220.813 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Commissioner's right to require acceleration. 220.813 Section 220.813 Housing and Urban Development Regulations Relating to Housing and Urban...'s right to require acceleration. Upon receipt of notice of the failure of the borrower to comply...

  12. 24 CFR 220.813 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Commissioner's right to require acceleration. 220.813 Section 220.813 Housing and Urban Development Regulations Relating to Housing and Urban...'s right to require acceleration. Upon receipt of notice of the failure of the borrower to comply...

  13. 24 CFR 220.813 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Commissioner's right to require acceleration. 220.813 Section 220.813 Housing and Urban Development Regulations Relating to Housing and Urban...'s right to require acceleration. Upon receipt of notice of the failure of the borrower to comply...

  14. 24 CFR 220.813 - Commissioner's right to require acceleration.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Commissioner's right to require acceleration. 220.813 Section 220.813 Housing and Urban Development Regulations Relating to Housing and Urban...'s right to require acceleration. Upon receipt of notice of the failure of the borrower to comply...

  15. 21 CFR 20.82 - Discretionary disclosure by the Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ....82 Section 20.82 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES..., disclose part or all of any Food and Drug Administration record that is otherwise exempt from disclosure pursuant to subpart D of this part. The Commissioner shall exercise his discretion to disclose such records...

  16. 21 CFR 20.82 - Discretionary disclosure by the Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ....82 Section 20.82 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES..., disclose part or all of any Food and Drug Administration record that is otherwise exempt from disclosure pursuant to subpart D of this part. The Commissioner shall exercise his discretion to disclose such records...

  17. 21 CFR 20.82 - Discretionary disclosure by the Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ....82 Section 20.82 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES..., disclose part or all of any Food and Drug Administration record that is otherwise exempt from disclosure pursuant to subpart D of this part. The Commissioner shall exercise his discretion to disclose such records...

  18. Commissioner Potočnik at Paranal Observatory

    NASA Astrophysics Data System (ADS)

    2007-10-01

    As part of his first official trip to Brazil and Chile, the European Science and Research Commissioner, Janez Potočnik, visited Europe's flagship for ground-based astronomy, the ESO Paranal Observatory. ESO PR Photo 48a/07 ESO PR Photo 48a/07 Commissioner Potočnik at the Control-Console of the VLT The major facility atop the 2600m high Paranal mountain in the Chilean Atacama Desert is the Very Large Telescope (VLT), whose design, instrument complement and operating principles set the standard for ground-based optical and infrared astronomy. The VLT Interferometer (VLTI) enhances the capabilities of this unique facility even further as do the survey telescopes VST (optical) and VISTA (infrared). Publication statistics show that the VLT provides data for a scientific paper every day, all year round. The Commissioner was accompanied, among others, by Jaime Pérez Vidal, Head of Delegation of the European Commission (EC) to Chile, Mary Minch and Cornelia Nauen, respectively Director and Principal Administrator of International Scientific Cooperation for the EC, and Hervé Peró, Head of EC Unit Research Infrastructures. The visitors were able to acquaint themselves with the VLT during an overnight stay at this remote site. The guests were welcomed by the ESO Director General, Tim de Zeeuw, the ESO Representative in Chile, Felix Mirabel, and the Director of the Paranal Observatory, Andreas Kaufer, as well as ESO staff members of many nationalities. The visitors were shown the various frontline installations at the observatory, including many of the distinctive VLT astronomical instruments that have been built in collaboration between ESO and European research institutes. The Commissioner was provided with a good impression of the wide range of exciting research programmes that are carried out with the VLT. ESO PR Photo 48b/07 ESO PR Photo 48b/07 Commissioner Potočnik Visiting the ESO Observatory at Paranal Having enjoyed the spectacular sunset over the Pacific Ocean

  19. Interjurisdictional collaboration: local public health officials versus county commissioners.

    PubMed

    Felton, John; Golbeck, Amanda L

    2011-01-01

    This study's primary objective was to determine where the viewpoints of public health officials and county commissioners differed on interjurisdictional collaboration in public health service delivery. After cataloging literature findings on interjurisdictional collaboration, an original questionnaire for 2 population groups within a cross-sectional design was developed. The questionnaire was administered in a rural or frontier state (Montana) that operates a generally decentralized public health system. Respondents (n = 83) were 29 lead local public health officials representing 34 counties, and 54 county commissioners representing 33 counties. Sixteen reasons to collaborate, 13 barriers to collaboration, and 18 policy considerations that would lead respondents to support or oppose a collaborative system were assessed, along with perceptions of current and ideal levels of interjurisdictional collaboration using the 4-level National Association of County and City Health Officials scale. Viewpoints of public health officials and county commissioners were found to differ significantly on 7 of 47 items. The potential benefit of improved surge capacity to manage large-scale events or emergencies was found by public health officials to be a more important reason to collaborate across jurisdictional lines. Long-standing commitment to home rule, current political climate, perceived threats to local elected officials, loss of local input into public health services and priorities, and lack of collaborative government and staffing models were all identified by public health officials as greater barriers to interjurisdictional collaboration. County commissioners were more likely to neither support nor oppose using existing disaster and emergency services district boundaries to define public health regional boundaries. Public health officials and county commissioners seem to have similar viewpoints on reasons to collaborate and policy considerations, but different viewpoints

  20. 17 CFR 140.11 - Emergency action by the senior Commissioner available.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Emergency action by the senior... the senior Commissioner available. (a) Authority of senior Commissioner. When it is not feasible to convene a quorum of the Commission, the Senior Commissioner present at the principal offices of...

  1. 21 CFR 570.15 - Adoption of regulation on initiative of Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Adoption of regulation on initiative of Commissioner. 570.15 Section 570.15 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Adoption of regulation on initiative of Commissioner. (a) The Commissioner upon his own initiative may...

  2. 21 CFR 570.15 - Adoption of regulation on initiative of Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Adoption of regulation on initiative of Commissioner. 570.15 Section 570.15 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... Adoption of regulation on initiative of Commissioner. (a) The Commissioner upon his own initiative may...

  3. 19 CFR 118.23 - Appeal to the Assistant Commissioner; procedure; status of CES operations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Appeal to the Assistant Commissioner; procedure... CES § 118.23 Appeal to the Assistant Commissioner; procedure; status of CES operations. (a) Appeal to the Assistant Commissioner. Appeal of a port director's decision under § 118.21(a) or (b) must be...

  4. 17 CFR 140.11 - Emergency action by the senior Commissioner available.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 2 2014-04-01 2014-04-01 false Emergency action by the senior... action by the senior Commissioner available. (a) Authority of senior Commissioner. When it is not feasible to convene a quorum of the Commission, the Senior Commissioner present at the principal offices of...

  5. 17 CFR 140.11 - Emergency action by the senior Commissioner available.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Emergency action by the senior... the senior Commissioner available. (a) Authority of senior Commissioner. When it is not feasible to convene a quorum of the Commission, the Senior Commissioner present at the principal offices of the...

  6. 17 CFR 140.11 - Emergency action by the senior Commissioner available.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Emergency action by the senior... the senior Commissioner available. (a) Authority of senior Commissioner. When it is not feasible to convene a quorum of the Commission, the Senior Commissioner present at the principal offices of the...

  7. 17 CFR 140.11 - Emergency action by the senior Commissioner available.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Emergency action by the senior... the senior Commissioner available. (a) Authority of senior Commissioner. When it is not feasible to convene a quorum of the Commission, the Senior Commissioner present at the principal offices of the...

  8. A theoretical description of charge reorganization energies in molecular organic P-type semiconductors.

    PubMed

    Brückner, Charlotte; Engels, Bernd

    2016-06-05

    Charge transport properties of materials composed of small organic molecules are important for numerous optoelectronic applications. A material's ability to transport charges is considerably influenced by the charge reorganization energies of the composing molecules. Hence, predictions about charge-transport properties of organic materials deserve reliable statements about these charge reorganization energies. However, using density functional theory which is mostly used for the predictions, the computed reorganization energies depend strongly on the chosen functional. To gain insight, a benchmark of various density functionals for the accurate calculation of charge reorganization energies is presented. A correlation between the charge reorganization energies and the ionization potentials is found which suggests applying IP-tuning to obtain reliable values for charge reorganization energies. According to benchmark investigations with IP-EOM-CCSD single-point calculations, the tuned functionals provide indeed more reliable charge reorganization energies. Among the standard functionals, ωB97X-D and SOGGA11X yield accurate charge reorganization energies in comparison with IP-EOM-CCSD values. © 2016 Wiley Periodicals, Inc.

  9. Decentralization in the New York City Department of Health: reorganization of a public health agency.

    PubMed Central

    Mustalish, A C; Eidsvold, G; Novick, L F

    1976-01-01

    Since the World War I era there has existed within the New York City Department of Health a basic internal struggle between staff directing the bureaus at the central office and the district health officers operating field health centers throughout the city. Recently, in a five-year period, there was a dramatic reorganization of the Department which markedly affected its orientation and programs. In 1972 a new Commissioner initiated a reorganization of the Department which succeeded in decentralizing field operations in contrast to earlier efforts which had failed to reach this objective. The roles of bureaus and districts were redefined, with the latter receiving budgetary authority, authority to supervise personnel, assignment of health managers, and the implementation of a district cost accounting system. While operational decentralization has occurred, policy setting and resource allocation in response to local needs remain central functions. PMID:795307

  10. Reorganizing SOF for Irregular Warfare

    DTIC Science & Technology

    2008-12-01

    after the Soviet Union launched Sputnik in 1957, the creation of the Environmental Protection Agency ( EPA ) in 1970, and the most recent reorganization...elliptical orbit some 550 miles above a Cold War-wracked planet. For the moment, at least, communism had trumped capitalism on a major front, and the

  11. The Commissioner's Annual Report: Submitted to the Congress by the Commissioner of Education in Accordance with Sec. 412. (b) of P. L. 91-230.

    ERIC Educational Resources Information Center

    Marland, S. P., Jr.

    An accounting is made in this report of the work of the Office of the Commissioner of Education during Fiscal Year 1970 and reflects the state of American education today. The Commissioner envisions the Federal role in education to be one of increasing the effectiveness of the human and financial resources of our schools, colleges and…

  12. Dynamic reorganization of river basins.

    PubMed

    Willett, Sean D; McCoy, Scott W; Perron, J Taylor; Goren, Liran; Chen, Chia-Yu

    2014-03-07

    River networks evolve as migrating drainage divides reshape river basins and change network topology by capture of river channels. We demonstrate that a characteristic metric of river network geometry gauges the horizontal motion of drainage divides. Assessing this metric throughout a landscape maps the dynamic states of entire river networks, revealing diverse conditions: Drainage divides in the Loess Plateau of China appear stationary; the young topography of Taiwan has migrating divides driving adjustment of major basins; and rivers draining the ancient landscape of the southeastern United States are reorganizing in response to escarpment retreat and coastal advance. The ability to measure the dynamic reorganization of river basins presents opportunities to examine landscape-scale interactions among tectonics, erosion, and ecology.

  13. Commission on Child Online Protection (COPA) Report to Congress [and] Personal Statements of COPA Commissioners.

    ERIC Educational Resources Information Center

    2000

    In October, 1998, Congress enacted the Child Online Protection Act and established the Commission on Online Child Protection (COPA) to study methods to help reduce access by minors to certain sexually explicit material, defined in the statute as harmful to minors. Congress directed the Commission to evaluate the accessibility, cost, and…

  14. The New Zealand Health and Disability Commissioner: a comparative assessment of the commissioner's contribution to protecting the rights of mental health consumers.

    PubMed

    Kazmierow, Maria

    2002-02-01

    The Health and Disabliity Commissioner's contribution to the protection of mental health consumers' rights is examined. This assessment covers a number of aspects. It includes the scope of consumer rights jurisdiction, the breadth of legal entitlements, protective mechanisms used, and the effectiveness of that protection. The Commissioner's role is also assessed comparatively. It is contrasted domestically with District Inspectors of Mental Health and internationally with Scottish and United Kingdom reform proposals. While analysis reveals considerable similarities, the New Zealand Health and Disability Commissioner is favourably highlighted in contrast with Scotland and the United Kingdom, particularly in the area of enforceability of mental health consumer rights.

  15. 77 FR 67653 - Statement of Organization, Functions, and Delegations of Authority; Office of the Deputy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ...Statement of Organizations, Functions, and Delegations of Authority. The Administration for Children and Families (ACF) has reorganized the Office of the Deputy Assistant Secretary for Administration (ODASA). This reorganization establishes the Office of Diversity Management and Equal Employment Opportunity (ODME). In addition, it realigns the acquisition oversight function to the Ethics Team in the Immediate Office of the Deputy Assistant Secretary for Administration.

  16. Reorganization: premises, processes, and pitfalls.

    PubMed Central

    Jacobson, S

    1994-01-01

    As the technological environment changes and libraries assume new and more active roles in their institutions, the traditional library hierarchy ceases to be an effective organizational structure. Guided by theories that emphasize teamwork, quality, and employee empowerment and participation, libraries are developing flatter, more networked organizations. The Health Sciences Library at Columbia University in New York, New York, recently underwent a reorganization in an effort to become a more resilient, more flexible organization. The process was beneficial overall. While some errors and confusion occurred, these are seen as opportunities for learning and evidence of the library's new atmosphere of creativity and experimentation. PMID:7841904

  17. 26 CFR 1.148-10 - Anti-abuse rules and authority of Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 2 2014-04-01 2014-04-01 false Anti-abuse rules and authority of Commissioner... Bonds § 1.148-10 Anti-abuse rules and authority of Commissioner. (a) Abusive arbitrage device—(1) In.... (c) Anti-abuse rules on excess gross proceeds of advance refunding issues—(1) In general. Except as...

  18. 26 CFR 1.148-10A - Anti-abuse rules and authority of Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 2 2011-04-01 2011-04-01 false Anti-abuse rules and authority of Commissioner. 1.148-10A Section 1.148-10A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... Prior to July 8, 1997 § 1.148-10A Anti-abuse rules and authority of Commissioner. (a) through (b)(1...

  19. 26 CFR 1.148-10A - Anti-abuse rules and authority of Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 2 2014-04-01 2014-04-01 false Anti-abuse rules and authority of Commissioner. 1.148-10A Section 1.148-10A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... Prior to July 8, 1997 § 1.148-10A Anti-abuse rules and authority of Commissioner. (a) through (b)(1...

  20. 26 CFR 1.148-10A - Anti-abuse rules and authority of Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 2 2012-04-01 2012-04-01 false Anti-abuse rules and authority of Commissioner. 1.148-10A Section 1.148-10A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... Prior to July 8, 1997 § 1.148-10A Anti-abuse rules and authority of Commissioner. (a) through (b)(1...

  1. 26 CFR 1.148-10A - Anti-abuse rules and authority of Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 2 2013-04-01 2013-04-01 false Anti-abuse rules and authority of Commissioner. 1.148-10A Section 1.148-10A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... Prior to July 8, 1997 § 1.148-10A Anti-abuse rules and authority of Commissioner. (a) through (b)(1...

  2. 26 CFR 1.148-10A - Anti-abuse rules and authority of Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Anti-abuse rules and authority of Commissioner. 1.148-10A Section 1.148-10A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... Prior to July 8, 1997 § 1.148-10A Anti-abuse rules and authority of Commissioner. (a) through (b)(1...

  3. 24 CFR 203.315 - Termination by conveyance to other than Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Termination by conveyance to other than Commissioner. 203.315 Section 203.315 Housing and Urban Development Regulations Relating...

  4. 24 CFR 207.259a - Waiver of title objection; mortgages formerly Commissioner-held.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Waiver of title objection; mortgages formerly Commissioner-held. 207.259a Section 207.259a Housing and Urban Development...

  5. 24 CFR 207.259a - Waiver of title objection; mortgages formerly Commissioner-held.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Waiver of title objection; mortgages formerly Commissioner-held. 207.259a Section 207.259a Housing and Urban Development...

  6. 24 CFR 203.315 - Termination by conveyance to other than Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Termination by conveyance to other than Commissioner. 203.315 Section 203.315 Housing and Urban Development Regulations Relating...

  7. 24 CFR 203.315 - Termination by conveyance to other than Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Termination by conveyance to other than Commissioner. 203.315 Section 203.315 Housing and Urban Development Regulations Relating...

  8. 24 CFR 207.259a - Waiver of title objection; mortgages formerly Commissioner-held.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Waiver of title objection; mortgages formerly Commissioner-held. 207.259a Section 207.259a Housing and Urban Development...

  9. 24 CFR 203.315 - Termination by conveyance to other than Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Termination by conveyance to other than Commissioner. 203.315 Section 203.315 Housing and Urban Development Regulations Relating...

  10. 24 CFR 203.315 - Termination by conveyance to other than Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Termination by conveyance to other than Commissioner. 203.315 Section 203.315 Housing and Urban Development Regulations Relating...

  11. 26 CFR 36.3121(l)(4)-1 - Termination of agreement by Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ....3121(l)(4)-1 Section 36.3121(l)(4)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... OF FOREIGN SUBSIDIARIES § 36.3121(l)(4)-1 Termination of agreement by Commissioner. (a) Notice of....3121(l)(1)-1 is in effect may be terminated by the Commissioner, with the prior concurrence of...

  12. Commissioner's Roundtable for Women in Educational Leadership in Florida. Proceedings (Tallahassee, Florida, November 20, 1991).

    ERIC Educational Resources Information Center

    Florida State Dept. of Education, Tallahassee.

    The proceedings of this roundtable discuss the current status of Florida women in educational leadership and ways to expand their opportunities for advancement. The report begins with an introduction and opening remarks by Florida's Assistant Commissioner of Education, Laurey T. Stryker and Florida Commissioner of Education, Betty Castor. A…

  13. 28 CFR 16.201 - Voting by the Commissioners without joint deliberation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Commissioners without joint deliberation. (a) Whenever the Commission's Chairman so directs, any matter which (1) does not appear to require joint deliberation among the members of the Commission, or (2) by reason of... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Voting by the Commissioners without...

  14. 26 CFR 36.3121(l)(4)-1 - Termination of agreement by Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ....3121(l)(4)-1 Section 36.3121(l)(4)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... OF FOREIGN SUBSIDIARIES § 36.3121(l)(4)-1 Termination of agreement by Commissioner. (a) Notice of....3121(l)(1)-1 is in effect may be terminated by the Commissioner, with the prior concurrence of the...

  15. 26 CFR 36.3121(l)(4)-1 - Termination of agreement by Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ....3121(l)(4)-1 Section 36.3121(l)(4)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... OF FOREIGN SUBSIDIARIES § 36.3121(l)(4)-1 Termination of agreement by Commissioner. (a) Notice of....3121(l)(1)-1 is in effect may be terminated by the Commissioner, with the prior concurrence of the...

  16. 26 CFR 36.3121(l)(4)-1 - Termination of agreement by Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ....3121(l)(4)-1 Section 36.3121(l)(4)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... OF FOREIGN SUBSIDIARIES § 36.3121(l)(4)-1 Termination of agreement by Commissioner. (a) Notice of....3121(l)(1)-1 is in effect may be terminated by the Commissioner, with the prior concurrence of the...

  17. 26 CFR 36.3121(l)(4)-1 - Termination of agreement by Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ....3121(l)(4)-1 Section 36.3121(l)(4)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... OF FOREIGN SUBSIDIARIES § 36.3121(l)(4)-1 Termination of agreement by Commissioner. (a) Notice of....3121(l)(1)-1 is in effect may be terminated by the Commissioner, with the prior concurrence of the...

  18. 28 CFR 0.98 - Functions of Commissioner of Federal Prison Industries.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Prison Industries. 0.98 Section 0.98 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Bureau of Prisons § 0.98 Functions of Commissioner of Federal Prison Industries. The Director of the Bureau of Prisons is authorized as ex officio Commissioner of Federal Prison Industries and...

  19. 28 CFR 0.98 - Functions of Commissioner of Federal Prison Industries.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Prison Industries. 0.98 Section 0.98 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Bureau of Prisons § 0.98 Functions of Commissioner of Federal Prison Industries. The Director of the Bureau of Prisons is authorized as ex officio Commissioner of Federal Prison Industries and...

  20. 28 CFR 0.98 - Functions of Commissioner of Federal Prison Industries.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Prison Industries. 0.98 Section 0.98 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Bureau of Prisons § 0.98 Functions of Commissioner of Federal Prison Industries. The Director of the Bureau of Prisons is authorized as ex officio Commissioner of Federal Prison Industries and...

  1. 28 CFR 0.98 - Functions of Commissioner of Federal Prison Industries.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Prison Industries. 0.98 Section 0.98 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE DEPARTMENT OF JUSTICE Bureau of Prisons § 0.98 Functions of Commissioner of Federal Prison Industries. The Director of the Bureau of Prisons is authorized as ex officio Commissioner of Federal Prison Industries and...

  2. Grant v Commissioner of Patents and patenting knowledge inventions.

    PubMed

    Lawson, Charles

    2008-02-01

    This article reviews the Full Federal Court decision in Grant v Commissioner of Patents (2006) 154 FCR 62; 69 IPR 221; [2006] FCAFC 120 denying patentability to a method for structuring a financial transaction so as to protect an individual's assets from a loss of ownership as a result of a legal liability. The article challenges the distinctions drawn by the Full Federal Court and argues that the decision marks a new development in setting a boundary for the Patents Act 1990 (Cth) "manner of manufacture". The article concludese that important questions now arise in assessing the possible application of the Patents Act 1990 (Cth) to promoting some inventions (and innovations) and not others, and whether there are other classes of inventions that also do not require the Patents Act 1990 (Cth) incentives.

  3. A Statement

    ERIC Educational Resources Information Center

    Mondale, Walter F.

    1973-01-01

    Article is a statement by Senator Walter F. Mondale, a Democrat from Minnesota, on the evaluation of social programs and a serious appraisal of social policy for the nation's children and their families. (Author/RK)

  4. Cut income taxes with reorganization planning.

    PubMed

    Miller, J E

    1985-04-01

    It is necessary to plan when reorganizing a corporate structure, to minimize taxes at the tax-exempt parent organization level and avoid unexpected tax consequences at year-end. With an awareness of the income tax rules, proper debt structuring during the reorganization phase is possible and should enable the financial manager to minimize total income tax.

  5. Lansing Community College Reorganization Overview Document.

    ERIC Educational Resources Information Center

    Lansing Community Coll., MI.

    In response to an unstable economy and diminishing resources, Lansing Community College, in Michigan, initiated a college-wide reorganization in July 1993 to improve institutional effectiveness and increase efficiency. This paper provides a description of the reorganization process and organizational structure before and after the change. First, a…

  6. Massive cortical reorganization in sighted Braille readers.

    PubMed

    Siuda-Krzywicka, Katarzyna; Bola, Łukasz; Paplińska, Małgorzata; Sumera, Ewa; Jednoróg, Katarzyna; Marchewka, Artur; Śliwińska, Magdalena W; Amedi, Amir; Szwed, Marcin

    2016-03-15

    The brain is capable of large-scale reorganization in blindness or after massive injury. Such reorganization crosses the division into separate sensory cortices (visual, somatosensory...). As its result, the visual cortex of the blind becomes active during tactile Braille reading. Although the possibility of such reorganization in the normal, adult brain has been raised, definitive evidence has been lacking. Here, we demonstrate such extensive reorganization in normal, sighted adults who learned Braille while their brain activity was investigated with fMRI and transcranial magnetic stimulation (TMS). Subjects showed enhanced activity for tactile reading in the visual cortex, including the visual word form area (VWFA) that was modulated by their Braille reading speed and strengthened resting-state connectivity between visual and somatosensory cortices. Moreover, TMS disruption of VWFA activity decreased their tactile reading accuracy. Our results indicate that large-scale reorganization is a viable mechanism recruited when learning complex skills.

  7. TUESDAY: EPA Administrator to Address National Association of Regulatory Utility Commissioners

    EPA Pesticide Factsheets

    WASHINGTON- On Tuesday, U.S. Environmental Protection Agency (EPA) Administrator Gina McCarthy will deliver remarks at the National Association of Regulatory Utility Commissioners' Winter Committee Meetings in Washington, DC. Administrator McCarthy

  8. TECHNOLOGY EVALUATION REPORT: TORONTO HARBOUR COMMISSIONERS (THC) SOIL RECYCLE TREATMENT TRAIN. Project Summary

    EPA Science Inventory

    A demonstration of the Toronto Harbour Commissioners' (THC) Soil Recycle Treatment Train was performed under the Superfund Innovative Technology Evaluation (SITE) Program at a pilot plant facility in Toronto, Ontario, Canada. The Soil Recycle Treatment Train, which consists of s...

  9. 77 FR 44609 - Notice of Commissioner and Staff Attendance at the National Association of Regulatory Utility...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... Regulatory Utility Commissioners 2012 Summer Committee Meetings The Federal Energy Regulatory Commission... found at http://summer.narucmeetings.org/agenda.cfm The discussions at these meetings, which are open...

  10. TECHNOLOGY EVALUATION REPORT: TORONTO HARBOUR COMMISSIONERS (THC) SOIL RECYCLE TREATMENT TRAIN. Project Summary

    EPA Science Inventory

    A demonstration of the Toronto Harbour Commissioners' (THC) Soil Recycle Treatment Train was performed under the Superfund Innovative Technology Evaluation (SITE) Program at a pilot plant facility in Toronto, Ontario, Canada. The Soil Recycle Treatment Train, which consists of s...

  11. Acetylcholine functionally reorganizes neocortical microcircuits

    PubMed Central

    Runfeldt, Melissa J.; Sadovsky, Alexander J.

    2014-01-01

    Sensory information is processed and transmitted through the synaptic structure of local cortical circuits, but it is unclear how modulation of this architecture influences the cortical representation of sensory stimuli. Acetylcholine (ACh) promotes attention and arousal and is thought to increase the signal-to-noise ratio of sensory input in primary sensory cortices. Using high-speed two-photon calcium imaging in a thalamocortical somatosensory slice preparation, we recorded action potential activity of up to 900 neurons simultaneously and compared local cortical circuit activations with and without bath presence of ACh. We found that ACh reduced weak pairwise relationships and excluded neurons that were already unreliable during circuit activity. Using action potential activity from the imaged population, we generated functional wiring diagrams based on the statistical dependencies of activity between neurons. ACh pruned weak functional connections from spontaneous circuit activations and yielded a more modular and hierarchical circuit structure, which biased activity to flow in a more feedforward fashion. Neurons that were active in response to thalamic input had reduced pairwise dependencies overall, but strong correlations were conserved. This coincided with a prolonged period during which neurons showed temporally precise responses to thalamic input. Our results demonstrate that ACh reorganizes functional circuit structure in a manner that may enhance the integration and discriminability of thalamic afferent input within local neocortical circuitry. PMID:24872527

  12. Reorganization for intravenous procedures in dentistry.

    PubMed

    Litchfield, N B

    1975-08-01

    The importance of reorganization for intravenous dental procedures, involving not only premises and equipment but also the dentist and his staff, is emphasised. These matters are discussed in detail with special emphasis on certain essential factors and psychologic aspects.

  13. PDGF induces reorganization of vimentin filaments.

    PubMed

    Valgeirsdóttir, S; Claesson-Welsh, L; Bongcam-Rudloff, E; Hellman, U; Westermark, B; Heldin, C H

    1998-07-30

    In this study we demonstrate that stimulation with platelet-derived growth factor (PDGF) leads to a marked reorganization of the vimentin filaments in porcine aortic endothelial (PAE) cells ectopically expressing the PDGF beta-receptor. Within 20 minutes after stimulation, the well-spread fine fibrillar vimentin was reorganized as the filaments aggregated into a dense coil around the nucleus. The solubility of vimentin upon Nonidet-P40-extraction of cells decreased considerably after PDGF stimulation, indicating that PDGF caused a redistribution of vimentin to a less soluble compartment. In addition, an increased tyrosine phosphorylation of vimentin was observed. The redistribution of vimentin was not a direct consequence of its tyrosine phosphorylation, since treatment of cells with an inhibitor for the cytoplasmic tyrosine kinase Src, attenuated phosphorylation but not redistribution of vimentin. These changes in the distribution of vimentin occurred in conjunction with reorganization of actin filaments. In PAE cells expressing a Y740/751F mutant receptor that is unable to bind and activate phosphatidylinositol 3'-kinase (PI3-kinase), the distribution of vimentin was virtually unaffected by PDGF stimulation. Thus, PI3-kinase is important for vimentin reorganization, in addition to its previously demonstrated role in actin reorganization. The small GTPase Rac has previously been shown to be involved downstream of PI3-kinase in the reorganization of actin filaments. In PAE cells overexpressing dominant negative Rac1 (N17Rac1), no change in the fine fibrillar vimentin network was seen after PDGF-BB stimulation, whereas in PAE cells overexpressing constitutively active Rac1 (V12Rac1), there was a dramatic change in vimentin filament organization independent of PDGF stimulation. These data indicate that PDGF causes a reorganization of microfilaments as well as intermediate filaments in its target cells and suggest an important role for Rac downstream of PI3-kinase in

  14. 76 FR 71919 - Corporate Reorganizations; Allocation of Basis in “All Cash D” Reorganizations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-21

    ... ``All Cash D'' Reorganizations AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice of... to understand. All comments will be available for public inspection and copying. A public hearing...

  15. 12 CFR 575.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Mutual holding company reorganizations. 575.3... COMPANIES § 575.3 Mutual holding company reorganizations. A mutual savings association may reorganize to become a mutual holding company, or join in a mutual holding company reorganization as an...

  16. 12 CFR 575.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 6 2013-01-01 2012-01-01 true Mutual holding company reorganizations. 575.3... COMPANIES § 575.3 Mutual holding company reorganizations. A mutual savings association may reorganize to become a mutual holding company, or join in a mutual holding company reorganization as an...

  17. 12 CFR 575.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Mutual holding company reorganizations. 575.3... COMPANIES § 575.3 Mutual holding company reorganizations. A mutual savings association may reorganize to become a mutual holding company, or join in a mutual holding company reorganization as an...

  18. 12 CFR 575.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Mutual holding company reorganizations. 575.3... COMPANIES § 575.3 Mutual holding company reorganizations. A mutual savings association may reorganize to become a mutual holding company, or join in a mutual holding company reorganization as an...

  19. 12 CFR 575.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 6 2012-01-01 2012-01-01 false Mutual holding company reorganizations. 575.3... COMPANIES § 575.3 Mutual holding company reorganizations. A mutual savings association may reorganize to become a mutual holding company, or join in a mutual holding company reorganization as an...

  20. Massive cortical reorganization in sighted Braille readers

    PubMed Central

    Siuda-Krzywicka, Katarzyna; Bola, Łukasz; Paplińska, Małgorzata; Sumera, Ewa; Jednoróg, Katarzyna; Marchewka, Artur; Śliwińska, Magdalena W; Amedi, Amir; Szwed, Marcin

    2016-01-01

    The brain is capable of large-scale reorganization in blindness or after massive injury. Such reorganization crosses the division into separate sensory cortices (visual, somatosensory...). As its result, the visual cortex of the blind becomes active during tactile Braille reading. Although the possibility of such reorganization in the normal, adult brain has been raised, definitive evidence has been lacking. Here, we demonstrate such extensive reorganization in normal, sighted adults who learned Braille while their brain activity was investigated with fMRI and transcranial magnetic stimulation (TMS). Subjects showed enhanced activity for tactile reading in the visual cortex, including the visual word form area (VWFA) that was modulated by their Braille reading speed and strengthened resting-state connectivity between visual and somatosensory cortices. Moreover, TMS disruption of VWFA activity decreased their tactile reading accuracy. Our results indicate that large-scale reorganization is a viable mechanism recruited when learning complex skills. DOI: http://dx.doi.org/10.7554/eLife.10762.001 PMID:26976813

  1. Cortical reorganization in children with cochlear implants.

    PubMed

    Gilley, Phillip M; Sharma, Anu; Dorman, Michael F

    2008-11-06

    Congenital deafness leads to atypical organization of the auditory nervous system. However, the extent to which auditory pathways reorganize during deafness is not well understood. We recorded cortical auditory evoked potentials in normal hearing children and in congenitally deaf children fitted with cochlear implants. High-density EEG and source modeling revealed principal activity from auditory cortex in normal hearing and early implanted children. However, children implanted after a critical period of seven years revealed activity from parietotemporal cortex in response to auditory stimulation, demonstrating reorganized cortical pathways. Reorganization of central auditory pathways is limited by the age at which implantation occurs, and may help explain the benefits and limitations of implantation in congenitally deaf children.

  2. A Legalization Program for Illegal Aliens Living in the United States. Statement before the Committee on the Judiciary, Subcommittee on Immigration, Refugees and International Law, House of Representatives.

    ERIC Educational Resources Information Center

    Meissner, Doris M.

    A legalization program for illegal aliens living in the United States is examined in this statement by Doris Meissner, Acting Commissioner of the Immigration and Naturalization Service (INS). Meissner states that the Administration's current proposed legislation is designed to regain control of the immigration process through the development of…

  3. Reorganizing the nursing home industry: a proposal.

    PubMed

    Shulman, D; Galanter, R

    1976-01-01

    This paper proposes a reorganization of the nursing home industry with capital facilities owned by government, but with management conducted through a system of competitive contracts with the private sector. The paper explicity demonstrates in real estate finance terms how the present system of private ownership of capital facilities inherently impedes providing a high quality of care. The authors believe that in the proposed industry reorganization, market forces, instead of working against quality care, would be supportive of quality care in a framework that would involve generally less regulation than exists today.

  4. Hospital reorganization and restructuring achieved through merger.

    PubMed

    Bazzoli, Gloria J; Losasso, Anthony; Arnould, Richard; Shalowitz, Madeleine

    2002-01-01

    This article examines hospital reorganization and restructuring activities following merger for two study periods: 1983-1988 and 1989-1996. In both periods, hospitals rated strengthening hospital financial position as the most important reason for merger. There were also similarities in reorganizing actions, especially reductions in service duplication, consolidation of departments and programs, reductions in medical and support FTEs, and reductions in administrative staffing. Hospital mergers during 1989-1996, however, focused increasingly on reducing nursing FTEs and less on converting acquired hospitals to new service lines.

  5. COMMUNITY CONFLICT RELATED TO SCHOOL DISTRICT REORGANIZATION.

    ERIC Educational Resources Information Center

    JONASSEN, CHRISTEN T.

    NORMATIVE SOCIAL AND CULTURAL FACTORS RELATING TO THE PROCESS OF SCHOOL REDISTRICTING AND CONSOLIDATION WERE IDENTIFIED AND DESCRIBED, AND SOME OF THE INTERRELATIONSHIPS BETWEEN THESE FACTORS DETERMINED. SUCH DATA COULD BE USED DURING A SCHOOL DISTRICT REORGANIZATION PROCESS BY BOTH EDUCATORS AND ADMINISTRATORS TO MINIMIZE TENSION AND MITIGATE THE…

  6. REORGANIZED SCIENCE CURRICULUM, 1, GRADE ONE SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE SECOND IN A SERIES OF17 VOLUMES, THIS VOLUME PROVIDES THE FIRST GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. A CHART INDICATES CONCEPT TO BE TAUGHT IN GRADES K-3 FOR EACH OF THE FOUR AREAS AROUND WHICH THE PROGRAM…

  7. REORGANIZED SCIENCE CURRICULUM, 3, GRADE THREE SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE FOURTH IN A SERIES OF 17 VOLUMES, THIS VOLUME PROVIDES THE THIRD GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. A CHART INDICATES CONCEPTS TO BE TAUGHT IN GRADES K-3 FOR EACH OF THE FOUR AREAS AROUND WHICH THE PROGRAM…

  8. REORGANIZED SCIENCE CURRICULUM, K, KINDERGARTEN SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THIS VOLUME PROVIDES THE KINDERGARTEN TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. A CHART INDICATES CONCEPTS TO BE TAUGHT IN GRADES K-3 FOR EACH OF THE FOUR AREAS AROUND WHICH THE PROGRAM IS DESIGNED. THE AREAS ARE (1) THE…

  9. REORGANIZED SCIENCE CURRICULUM, 2, GRADE TWO SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE THIRD IN A SERIES OF 17 VOLUMES, THIS VOLUME PROVIDES THE SECOND GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. A CHART INDICATES CONCEPTS TO BE TAUGHT IN GRADES K-3, IN EACH OF THE FOUR AREAS AROUND WHICH THE PROGRAM…

  10. Library Reorganization & Restructuring. SPEC Kit 215.

    ERIC Educational Resources Information Center

    Eustis, Joanne D., Comp.; Kenney, Donald J. Comp.

    As the entity traditionally responsible for serving the information needs of the university, research libraries have little choice but to change dramatically in the next 25 years. This SPEC Survey on library reorganization seeks to understand how librarians have sought to meet this challenge through the redesigning of their organization.…

  11. REORGANIZED SCIENCE CURRICULUM, 8, GRADE EIGHT SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE FOURTEENTH IN A SERIES OF 17 VOLUMES, THIS VOLUME PROVIDES THE EIGHTH GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE AUGMENTED AND REVISED AS THE NEED ARISES. A CHART INDICATES CONCEPT BRIEF SUMMARY OF SUBJECT MATTER CONTENT FOR GRADE 8, AND A CHART OF THE GRADE CONTENT FOR…

  12. 78 FR 54455 - Permanent Advisory Committee to Advise the U.S. Commissioners to the Western and Central Pacific...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-04

    ... Committee (PAC) to advise the U.S. Commissioners to the Western and Central Pacific Fisheries Commission... section of this notice. DATES: The meeting of the PAC will be held on October 28, 2013, from 8 a.m. to 4 p... consultation with the U.S. Commissioners to the WCPFC, has appointed a Permanent Advisory Committee or PAC...

  13. 76 FR 34220 - Commissioners of Public Works of the City of Spartanburg, SC; Notice of Application for Surrender...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-13

    ... Energy Regulatory Commission Commissioners of Public Works of the City of Spartanburg, SC; Notice of..., 2010 and supplemented on May 19, 2011. d. Applicant: Commissioners of Public Works of the City of... that the following application has been filed with the Commission and is available for...

  14. 75 FR 2126 - Clifton Power Corporation; Commissioner of Public Works of the City of Spartanburg, SC; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Clifton Power Corporation; Commissioner of Public Works of the City of... Intervene January 7, 2010. On November 4, 2009, Commissioner of Public Works of the City of...

  15. 17 CFR 250.63 - Approval of reorganization fees.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) GENERAL RULES AND REGULATIONS, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 Solicitations and Reorganizations § 250.63 Approval of reorganization fees. All fees, expenses and remuneration, whether interim or...

  16. Upgrading the U.S. Workplace: Do Reorganization, Education Help?

    ERIC Educational Resources Information Center

    Bassi, Laurie J.

    1995-01-01

    Surveys of companies involved in reorganization found that firms that establish workplace education programs and reorganize work report noticeable improvements in their employees' abilities and the quality of their products. (Author)

  17. 12 CFR 239.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 4 2014-01-01 2014-01-01 false Mutual holding company reorganizations. 239.3... RESERVE SYSTEM (CONTINUED) MUTUAL HOLDING COMPANIES (REGULATION MM) Mutual Holding Companies § 239.3 Mutual holding company reorganizations. (a) A mutual savings association may not reorganize to become...

  18. 12 CFR 239.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Mutual holding company reorganizations. 239.3... RESERVE SYSTEM (CONTINUED) MUTUAL HOLDING COMPANIES (REGULATION MM) Mutual Holding Companies § 239.3 Mutual holding company reorganizations. (a) A mutual savings association may not reorganize to become...

  19. 12 CFR 239.3 - Mutual holding company reorganizations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 4 2012-01-01 2012-01-01 false Mutual holding company reorganizations. 239.3... RESERVE SYSTEM (CONTINUED) MUTUAL HOLDING COMPANIES (REGULATION MM) Mutual Holding Companies § 239.3 Mutual holding company reorganizations. (a) A mutual savings association may not reorganize to become...

  20. 12 CFR 575.4 - Grounds for disapproval of reorganizations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... resources. Failure by a reorganizing association and any acquiree association to submit a business plan in connection with a Reorganization Notice, or submission of a business plan that projects activities that are... materially, from the business plan submitted in connection with the Reorganization Notice, unless...

  1. Apportionment for Prekindergarten Programs. Amendment to the Regulations of the Commissioner of Education, Part 151.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany. Office of Parent Education, Student and Child Development and Community School Programs.

    The purpose of Part 151 of the regulations of the New York Commissioner of Education is to carry out the legislative intent to provide financial assistance to school districts. This assistance is provided for the operation of experimental prekindergarten programs for children with educational needs associated with poverty. Section 2 of Part 151…

  2. SITE DEMONSTRATION BULLETIN: SOIL RECYCLING TREATMENT TRAIN - THE TORONTO HARBOUR COMMISSIONERS

    EPA Science Inventory

    The Toronto Harbour Commissioners (THC) have developed a soil treatment train designed to treat inorganic and organic contaminants in soils. THC has conducted a large-scale demonstration of these technologies in an attempt to establish that contaminated soils at the Toronto Port...

  3. 28 CFR 2.24 - Review of panel recommendation by the Regional Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Review of panel recommendation by the Regional Commissioner. 2.24 Section 2.24 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS, YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States...

  4. 28 CFR 2.24 - Review of panel recommendation by the Regional Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Review of panel recommendation by the Regional Commissioner. 2.24 Section 2.24 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS, YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States...

  5. 28 CFR 16.201 - Voting by the Commissioners without joint deliberation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Voting by the Commissioners without joint deliberation. 16.201 Section 16.201 Judicial Administration DEPARTMENT OF JUSTICE PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Public Observation of Parole Commission Meetings § 16.201 Voting by...

  6. 28 CFR 16.201 - Voting by the Commissioners without joint deliberation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Voting by the Commissioners without joint deliberation. 16.201 Section 16.201 Judicial Administration DEPARTMENT OF JUSTICE PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Public Observation of Parole Commission Meetings § 16.201 Voting by...

  7. 28 CFR 16.201 - Voting by the Commissioners without joint deliberation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Voting by the Commissioners without joint deliberation. 16.201 Section 16.201 Judicial Administration DEPARTMENT OF JUSTICE PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Public Observation of Parole Commission Meetings § 16.201 Voting by...

  8. 28 CFR 16.201 - Voting by the Commissioners without joint deliberation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Voting by the Commissioners without joint deliberation. 16.201 Section 16.201 Judicial Administration DEPARTMENT OF JUSTICE PRODUCTION OR DISCLOSURE OF MATERIAL OR INFORMATION Public Observation of Parole Commission Meetings § 16.201 Voting by the...

  9. 76 FR 71966 - Notice of Commissioner and Staff Attendance at ReliabilityFirst

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Commissioner and Staff Attendance at ReliabilityFirst Corporation Meetings The Federal Energy Regulatory Commission hereby gives notice that members of the Commission and/or Commission staff may attend...

  10. 20 CFR 423.3 - Other process directed to the Social Security Administration or the Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Other process directed to the Social Security Administration or the Commissioner. 423.3 Section 423.3 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SERVICE OF PROCESS § 423.3 Other process directed to the Social Security Administration or...

  11. 20 CFR 423.3 - Other process directed to the Social Security Administration or the Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Other process directed to the Social Security Administration or the Commissioner. 423.3 Section 423.3 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SERVICE OF PROCESS § 423.3 Other process directed to the Social Security Administration or...

  12. 20 CFR 423.3 - Other process directed to the Social Security Administration or the Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Other process directed to the Social Security Administration or the Commissioner. 423.3 Section 423.3 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SERVICE OF PROCESS § 423.3 Other process directed to the Social Security Administration or...

  13. 20 CFR 423.3 - Other process directed to the Social Security Administration or the Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Other process directed to the Social Security Administration or the Commissioner. 423.3 Section 423.3 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SERVICE OF PROCESS § 423.3 Other process directed to the Social Security Administration or...

  14. 20 CFR 423.3 - Other process directed to the Social Security Administration or the Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Other process directed to the Social Security Administration or the Commissioner. 423.3 Section 423.3 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SERVICE OF PROCESS § 423.3 Other process directed to the Social Security Administration or...

  15. 77 FR 26537 - Notice of Commissioners and Staff Attendance at FERC Leadership Development Program Graduation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-04

    ... Energy Regulatory Commission Notice of Commissioners and Staff Attendance at FERC Leadership Development Program Graduation/Induction Ceremony The Federal Energy Regulatory Commission (FERC or Commission) hereby gives notice that members of the Commission and/or Commission staff may attend the following event: FERC...

  16. 76 FR 5799 - Notice of Commissioners and Staff Attendance at FERC Leadership Development Program Induction...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-02

    ... Energy Regulatory Commission Notice of Commissioners and Staff Attendance at FERC Leadership Development Program Induction Ceremony January 26, 2011. The Federal Energy Regulatory Commission (FERC or Commission) hereby gives notice that members of the Commission and/or Commission staff may attend the following event...

  17. 19 CFR 191.1 - Authority of the Commissioner of Customs.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Authority of the Commissioner of Customs. 191.1 Section 191.1 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY... Customs. Pursuant to Treasury Department Order No. 165, Revised (T.D. 53654, 19 FR 7241), as amended,...

  18. 19 CFR 115.18 - Decision of Commissioner of Customs final.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Decision of Commissioner of Customs final. 115.18 Section 115.18 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CARGO CONTAINER AND ROAD VEHICLE CERTIFICATION PURSUANT TO INTERNATIONAL...

  19. 43 CFR 422.4 - Responsibilities of the Commissioner of Reclamation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Responsibilities of the Commissioner of Reclamation. 422.4 Section 422.4 Public Lands: Interior Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR LAW ENFORCEMENT AUTHORITY AT BUREAU OF RECLAMATION...

  20. 43 CFR 422.4 - Responsibilities of the Commissioner of Reclamation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Reclamation. 422.4 Section 422.4 Public Lands: Interior Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR LAW ENFORCEMENT AUTHORITY AT BUREAU OF RECLAMATION PROJECTS Responsibilities § 422.4 Responsibilities of the Commissioner of Reclamation. (a) The Secretary of the Interior has...

  1. 43 CFR 422.4 - Responsibilities of the Commissioner of Reclamation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Reclamation. 422.4 Section 422.4 Public Lands: Interior Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR LAW ENFORCEMENT AUTHORITY AT BUREAU OF RECLAMATION PROJECTS Responsibilities § 422.4 Responsibilities of the Commissioner of Reclamation. (a) The Secretary of the Interior has...

  2. 43 CFR 422.4 - Responsibilities of the Commissioner of Reclamation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Reclamation. 422.4 Section 422.4 Public Lands: Interior Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR LAW ENFORCEMENT AUTHORITY AT BUREAU OF RECLAMATION PROJECTS Responsibilities § 422.4 Responsibilities of the Commissioner of Reclamation. (a) The Secretary of the Interior has...

  3. 43 CFR 422.4 - Responsibilities of the Commissioner of Reclamation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Reclamation. 422.4 Section 422.4 Public Lands: Interior Regulations Relating to Public Lands BUREAU OF RECLAMATION, DEPARTMENT OF THE INTERIOR LAW ENFORCEMENT AUTHORITY AT BUREAU OF RECLAMATION PROJECTS Responsibilities § 422.4 Responsibilities of the Commissioner of Reclamation. (a) The Secretary of the Interior has...

  4. 76 FR 14407 - Exchange of Letters Between Dr. Murray M. Lumpkin, Deputy Commissioner, International Programs...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration Exchange of Letters Between Dr. Murray M. Lumpkin, Deputy... providing notice of exchange of letters between Dr. Murray M. Lumpkin, Deputy Commissioner, International...

  5. 21 CFR 860.132 - Procedures when the Commissioner initiates a performance standard or premarket approval...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) MEDICAL DEVICES MEDICAL DEVICE CLASSIFICATION PROCEDURES Reclassification § 860.132 Procedures... the classification of a device based upon new information relevant to its classification when the Commissioner initiates a proceeding either to develop a performance standard for the device if in class II,...

  6. 21 CFR 860.132 - Procedures when the Commissioner initiates a performance standard or premarket approval...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Procedures when the Commissioner initiates a... Section 860.132 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES MEDICAL DEVICE CLASSIFICATION PROCEDURES Reclassification § 860.132...

  7. Summary of Second Language Provisions in the New Part 100 of the Commissioner's Regulations.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany. Bureau of Foreign Languages Education.

    An overview of the foreign language requirements in the new Part 100 of the New York State Commissioner's regulations for public schools is presented to aid local school personnel in designing foreign language programs and advising students regarding the new statewide requirements. The summary first defines the terms used, and then outlines: the…

  8. 77 FR 5791 - Notice of Commissioner and Staff Attendance at the National Association of Regulatory Utility...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-06

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Commissioner and Staff Attendance at the National... South Carolina and the South Carolina Office of Regulatory Staff Docket No. AD12-1-000, Commission Role...

  9. 24 CFR 203.320 - Notice and date of termination by Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Notice and date of termination by Commissioner. 203.320 Section 203.320 Housing and Urban Development Regulations Relating to Housing and...

  10. 24 CFR 203.320 - Notice and date of termination by Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Notice and date of termination by Commissioner. 203.320 Section 203.320 Housing and Urban Development Regulations Relating to Housing and...

  11. 24 CFR 207.256 - Notice to the Commissioner of default.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Notice to the Commissioner of default. 207.256 Section 207.256 Housing and Urban Development Regulations Relating to Housing and...

  12. 24 CFR 203.320 - Notice and date of termination by Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Notice and date of termination by Commissioner. 203.320 Section 203.320 Housing and Urban Development Regulations Relating to Housing and...

  13. 24 CFR 203.320 - Notice and date of termination by Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Notice and date of termination by Commissioner. 203.320 Section 203.320 Housing and Urban Development Regulations Relating to Housing and...

  14. 24 CFR 207.256 - Notice to the Commissioner of default.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Notice to the Commissioner of default. 207.256 Section 207.256 Housing and Urban Development Regulations Relating to Housing and...

  15. 24 CFR 203.320 - Notice and date of termination by Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Notice and date of termination by Commissioner. 203.320 Section 203.320 Housing and Urban Development Regulations Relating to Housing and...

  16. TORONTO HARBOUR COMMISSIONERS (THC) SOIL RECYCLE TREATMENT TRAIN - APPLICATIONS ANALYSIS REPORT

    EPA Science Inventory

    The Toronto Harbour Commissioners (THC) have developed a soil treatment train designed to treat inorganic and organic contaminants in soils. THC has conducted a large-scale demonstration of these technologies in an attempt to establish that contaminated soils at the Toronto Port ...

  17. 78 FR 66425 - Advisory Group to the Commissioner of Internal Revenue; Renewal of Charter

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ... Internal Revenue Service Advisory Group to the Commissioner of Internal Revenue; Renewal of Charter AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice. SUMMARY: The Charter for the Information... concern as between Internal Revenue Service (``IRS'') officials and ] representatives of the public...

  18. 76 FR 67556 - Advisory Group to the Commissioner of Internal Revenue; Renewal of Charter

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-01

    ... Internal Revenue Service Advisory Group to the Commissioner of Internal Revenue; Renewal of Charter AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice. SUMMARY: The Charter for the Information... concern as between Internal Revenue Service (``IRS'') officials and representatives of the public...

  19. TORONTO HARBOUR COMMISSIONERS (THC) SOIL RECYCLE TREATMENT TRAIN - APPLICATIONS ANALYSIS REPORT

    EPA Science Inventory

    The Toronto Harbour Commissioners (THC) have developed a soil treatment train designed to treat inorganic and organic contaminants in soils. THC has conducted a large-scale demonstration of these technologies in an attempt to establish that contaminated soils at the Toronto Port ...

  20. 20 CFR 702.105 - Use of the title District Director in place of Deputy Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false Use of the title District Director in place of Deputy Commissioner. 702.105 Section 702.105 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR LONGSHOREMEN'S AND HARBOR WORKERS' COMPENSATION ACT AND RELATED...

  1. 20 CFR 702.105 - Use of the title District Director in place of Deputy Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Use of the title District Director in place of Deputy Commissioner. 702.105 Section 702.105 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR LONGSHOREMEN'S AND HARBOR WORKERS' COMPENSATION ACT AND RELATED...

  2. 20 CFR 702.105 - Use of the title District Director in place of Deputy Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Use of the title District Director in place of Deputy Commissioner. 702.105 Section 702.105 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR LONGSHOREMEN'S AND HARBOR WORKERS' COMPENSATION ACT AND RELATED...

  3. 20 CFR 702.105 - Use of the title District Director in place of Deputy Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Use of the title District Director in place of Deputy Commissioner. 702.105 Section 702.105 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR LONGSHOREMEN'S AND HARBOR WORKERS' COMPENSATION ACT AND RELATED...

  4. 20 CFR 702.105 - Use of the title District Director in place of Deputy Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Use of the title District Director in place of Deputy Commissioner. 702.105 Section 702.105 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR LONGSHOREMEN'S AND HARBOR WORKERS' COMPENSATION ACT AND RELATED...

  5. 28 CFR 2.24 - Review of panel recommendation by the Regional Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Review of panel recommendation by the Regional Commissioner. 2.24 Section 2.24 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS, YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States...

  6. 28 CFR 2.59 - Designation of a Commissioner to act as a hearing examiner.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Designation of a Commissioner to act as a hearing examiner. 2.59 Section 2.59 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND RECOMMITMENT OF PRISONERS, YOUTH OFFENDERS, AND JUVENILE DELINQUENTS United States...

  7. 77 FR 63811 - Notice of Commissioners and Staff Attendance at FERC Author Speaker Series Event

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Commissioners and Staff Attendance at FERC Author Speaker Series... the Commission and/or Commission staff may attend the following event: Author Speaker Series featuring...

  8. 17 CFR 200.43 - Disposition of business by exercise of authority delegated to individual Commissioner.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... exercise of authority delegated to individual Commissioner. 200.43 Section 200.43 Commodity and Securities... Disposition of Commission Business § 200.43 Disposition of business by exercise of authority delegated to... Commission; Provided, however, That no such delegation shall authorize the duty officer (i) to exercise...

  9. 17 CFR 200.43 - Disposition of business by exercise of authority delegated to individual Commissioner.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... exercise of authority delegated to individual Commissioner. 200.43 Section 200.43 Commodity and Securities... Disposition of Commission Business § 200.43 Disposition of business by exercise of authority delegated to... Commission; Provided, however, That no such delegation shall authorize the duty officer (i) to exercise...

  10. 17 CFR 200.43 - Disposition of business by exercise of authority delegated to individual Commissioner.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... exercise of authority delegated to individual Commissioner. 200.43 Section 200.43 Commodity and Securities... Disposition of Commission Business § 200.43 Disposition of business by exercise of authority delegated to... Commission; Provided, however, That no such delegation shall authorize the duty officer (i) to exercise...

  11. 17 CFR 200.43 - Disposition of business by exercise of authority delegated to individual Commissioner.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... exercise of authority delegated to individual Commissioner. 200.43 Section 200.43 Commodity and Securities... Disposition of Commission Business § 200.43 Disposition of business by exercise of authority delegated to... Commission; Provided, however, That no such delegation shall authorize the duty officer (i) to exercise...

  12. 17 CFR 200.43 - Disposition of business by exercise of authority delegated to individual Commissioner.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... exercise of authority delegated to individual Commissioner. 200.43 Section 200.43 Commodity and Securities... Disposition of Commission Business § 200.43 Disposition of business by exercise of authority delegated to... Commission; Provided, however, That no such delegation shall authorize the duty officer (i) to exercise...

  13. Seafloor Spreading Reorganization South of Iceland

    NASA Astrophysics Data System (ADS)

    Hey, R. N.; Martinez, F.; Benediktsdottir, A.; Hoskuldsson, A.

    2011-12-01

    There is a major ongoing diachronous reorganization of North Atlantic seafloor spreading occurring at present south of Iceland, from an orthogonal ridge/transform geometry to the present oblique spreading geometry without transform faults on the Reykjanes Ridge. This reorganization is presently interpreted as a thermal phenomenon, with a pulse of warmer mantle expanding away from the Iceland plume causing a progressive change in subaxial mantle rheology from brittle to ductile, so that transform faults can no longer be maintained. Given that this is certainly the most obvious and arguably the type-example of active plate boundary reorganization, it is somewhat surprising that a thermal mechanism has near universal acceptance here whereas most if not all other seafloor spreading reorganizations are equally universally thought to result from the tectonic rift propagation mechanism. This suggests the possibility that either the thermal model might be wrong here, or that the propagating rift (PR) model might be wrong elsewhere. The reason the PR alternative was ignored here was that the younger seafloor record flanking the Reykjanes Ridge consisting of V-shaped ridges, troughs & scarps (VSRs) enclosed by the reorganization wake seemed to prove that there had been no rift propagation. It had long been thought that these VSRs were symmetric about the spreading axis, & if this conventional wisdom (that led directly to the pulsing Iceland plume model) were true, rift propagation, which must produce asymmetry, could not have occurred. However, our expedition collected marine geophysical data that showed that the VSRs actually have an asymmetric geometry consistent with rift propagation, not with previous pulsing plume models, & thus they can no longer be considered convincing proof of a pulsing Iceland plume. Although we had previously noted that plume pulses might drive the propagators away from Iceland, a significant new result (Benediktsdóttir et al., 2011) is that

  14. Active biopolymers confer fast reorganization kinetics.

    PubMed

    Swanson, Douglas; Wingreen, Ned S

    2011-11-18

    Many cytoskeletal biopolymers are "active," consuming energy in large quantities. In this Letter, we identify a fundamental difference between active polymers and passive, equilibrium polymers: for equal mean lengths, active polymers can reorganize faster than equilibrium polymers. We show that equilibrium polymers are intrinsically limited to linear scaling between mean lifetime (or mean first-passage time, or MFPT) and mean length, MFPT∼, by analogy to 1D Potts models. By contrast, we present a simple active-polymer model that improves upon this scaling, such that MFPT∼(1/2). Since, to be biologically useful, structural biopolymers must typically be many monomers long yet respond dynamically to the needs of the cell, the difference in reorganization kinetics may help to justify the active polymers' greater energy cost.

  15. Cortical Reorganization following Injury Early in Life

    PubMed Central

    Artzi, Moran; Shiran, Shelly Irene; Weinstein, Maya; Myers, Vicki; Tarrasch, Ricardo; Schertz, Mitchell; Fattal-Valevski, Aviva; Miller, Elka; Gordon, Andrew M.; Green, Dido; Ben Bashat, Dafna

    2016-01-01

    The brain has a remarkable capacity for reorganization following injury, especially during the first years of life. Knowledge of structural reorganization and its consequences following perinatal injury is sparse. Here we studied changes in brain tissue volume, morphology, perfusion, and integrity in children with hemiplegia compared to typically developing children, using MRI. Children with hemiplegia demonstrated reduced total cerebral volume, with increased cerebrospinal fluid (CSF) and reduced total white matter volumes, with no differences in total gray matter volume, compared to typically developing children. An increase in cortical thickness at the hemisphere contralateral to the lesion (CLH) was detected in motor and language areas, which may reflect compensation for the gray matter loss in the lesion area or retention of ipsilateral pathways. In addition, reduced cortical thickness, perfusion, and surface area were detected in limbic areas. Increased CSF volume and precentral cortical thickness and reduced white matter volume were correlated with worse motor performance. Brain reorganization of the gray matter within the CLH, while not necessarily indicating better outcome, is suggested as a response to neuronal deficits following injury early in life. PMID:27298741

  16. 77 FR 43831 - Statement of Organization, Functions, and Delegations of Authority

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-26

    ... FR 27070-27071, dated May 8, 2012) is amended to reorganize the Human Capital and Resources... functional statements for the Human Capital and Resources Management Office (CAJQ) and insert the following: Human Capital and Resources Management Office (CAJ0). (1) Provides leadership, policy...

  17. 78 FR 60880 - Statement of Organization, Functions, and Delegations of Authority

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ... HUMAN SERVICES Administration for Children and Families Statement of Organization, Functions, and Delegations of Authority AGENCY: Office of Child Support Enforcement, Administration for Children and Families... Administration for Children and Families (ACF) has reorganized the Office of Child Support Enforcement (OCSE...

  18. Survey of state insurance commissioners concerning genetic testing and life insurance

    SciTech Connect

    McEwen, J.E.; McCarty, K.; Reilly, P.R. )

    1992-10-01

    Rapid advances in genetic testing have stimulated growing concern about the potential for misuse of genetic data by insurance companies, employers, and other third parties. Thus far, reports of genetically based discrimination in life insurance have been anecdotal. Reasoning that state insurance commissioners were likely to be aware of (1) the extent of current use of and interest in genetic tests by life insurers and (2) consumer complaints about insurance being denied because of genetic condition or because of genetic test results, the authors conducted a survey of that group. They received responses from 42 of the 51 jurisdictions. Results suggest (1) that those who regulate the life insurance industry do not yet perceive genetic testing to pose a significant problem in how insurers rate applicants, (2) that life insurers have much legal latitude to require genetic tests, and (3) that so far few consumers have formally complained to commissioners about the use of genetic data by life insurers.

  19. Prioritizing investment in public health and health equity: what can commissioners do?

    PubMed

    Marks, L; Weatherly, H; Mason, A

    2013-05-01

    To explore commissioners' views on prioritizing for investment in health. This study reviewed: methods for decision support; their relevance for prioritizing health and health equity in principle; and their adoption by decision makers in practice. Decision makers' views were sought through semi-structured interviews and an online survey, and prioritization tools were reviewed. Interviews were held in 2008-2009 with a subsample followed up in 2009-2010. In late 2009, a national online survey was sent to 508 individuals across 146 primary care trusts (PCTs). The two phases of the interviews comprised 52 and 17 participants, respectively. Responses to the national survey were received from 138 decision makers in 95 (65%) PCTs. Prioritization tools were identified through interviews and the survey as above, a rapid review of literature and in consultation with health economists. A grounded theory approach was adopted for the qualitative interview analysis. Although most PCTs used a prioritization framework, few of the tools identified in this review were used by public health commissioners. This was partly a consequence of limitations of priority-setting tools in the context of public health investment, and partly a lack of relevant skills and data. Tensions in relation to developing strategies for disinvestment and in prioritizing a long-term public health agenda in a context of economic austerity were evident. The context for decision making appears to be more important than the deployment of specific tools and techniques. Commissioners need to recognize the limitations of priority-setting tools, but also know how to apply them to help maximize health gain and health equity over the longer term. Decision-support tools should be developed in collaboration with public health commissioners to ensure relevance and practicality of use. Copyright © 2013 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  20. 43 CFR 417.5 - Duties of the Commissioner of Indian Affairs with respect to Indian reservations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... IMPLEMENTING COLORADO RIVER WATER CONSERVATION MEASURES WITH LOWER BASIN CONTRACTORS AND OTHERS § 417.5 Duties... diversion, delivery, distribution and use of Colorado River water, the Commissioner shall, within the limits...

  1. 43 CFR 417.5 - Duties of the Commissioner of Indian Affairs with respect to Indian reservations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... IMPLEMENTING COLORADO RIVER WATER CONSERVATION MEASURES WITH LOWER BASIN CONTRACTORS AND OTHERS § 417.5 Duties... diversion, delivery, distribution and use of Colorado River water, the Commissioner shall, within the limits...

  2. 43 CFR 417.5 - Duties of the Commissioner of Indian Affairs with respect to Indian reservations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... IMPLEMENTING COLORADO RIVER WATER CONSERVATION MEASURES WITH LOWER BASIN CONTRACTORS AND OTHERS § 417.5 Duties... diversion, delivery, distribution and use of Colorado River water, the Commissioner shall, within the limits...

  3. [Tasks and experiences of the Federal Government Commissioner for Patients' Affairs].

    PubMed

    Kühn-Mengel, H

    2009-01-01

    On the basis of Section 140h of Social Code Book V (German abbreviation: SGB V), which had been newly included in 2004, the Federal Government Commissioner for Patients' Affairs speaks out in favor of a meticulous implementation of patients' right to education, information and joint decision-making in all spheres of the health care system, whenever the commissioner attends the respective panels or events, and also in public. Currently, the commissioner is member of a parliamentary working group which is charged with the elaboration of the contents of a law relating to patients' rights, and experts and patients' organizations are involved in this procedure as well. For this purpose, but also with regard to other key panels of the health care system, self-help organizations are important partners for collaboration, due to their commitment, their experiences and the inspirations they provide. Therefore, they have been strengthened in essential aspects by the policy of the Federal Government over the past few years.

  4. Dynamic reorganization of the actin cytoskeleton

    PubMed Central

    Gressin, Laurène; Théry, Manuel; Blanchoin, Laurent

    2015-01-01

    Cellular processes, including morphogenesis, polarization, and motility, rely on a variety of actin-based structures. Although the biochemical composition and filament organization of these structures are different, they often emerge from a common origin. This is possible because the actin structures are highly dynamic. Indeed, they assemble, grow, and disassemble in a time scale of a second to a minute. Therefore, the reorganization of a given actin structure can promote the formation of another. Here, we discuss such transitions and illustrate them with computer simulations. PMID:26989473

  5. Dynamic reorganization of the actin cytoskeleton.

    PubMed

    Letort, Gaëlle; Ennomani, Hajer; Gressin, Laurène; Théry, Manuel; Blanchoin, Laurent

    2015-01-01

    Cellular processes, including morphogenesis, polarization, and motility, rely on a variety of actin-based structures. Although the biochemical composition and filament organization of these structures are different, they often emerge from a common origin. This is possible because the actin structures are highly dynamic. Indeed, they assemble, grow, and disassemble in a time scale of a second to a minute. Therefore, the reorganization of a given actin structure can promote the formation of another. Here, we discuss such transitions and illustrate them with computer simulations.

  6. Evidence of cortical reorganization in hemiparetic patients

    SciTech Connect

    Brion, J.P.; Demeurisse, G.; Capon, A. )

    1989-08-01

    We studied the mechanisms underlying the recovery of motor function of the hand using a bidimensional xenon-133 inhalation technique to measure regional cerebral blood flow at rest and during the performance of a motor task (test condition). The regional cerebral blood flow patterns under rest and test conditions were compared in normal control and in stroke patients with either a cortico-subcortical or a deep-seated lesion. Functional recovery appears to depend upon cortical reorganization involving both hemispheres, particularly in both parietal regions in the subgroup of patients with cortico-subcortical lesions.

  7. Do marginal investments made by NHS healthcare commissioners in the UK produce the outcomes they hope to achieve? Observational study

    PubMed Central

    O'Cathain, Alicia; Sampson, Fiona; Strong, Mark; Pickin, Mark; Goyder, Elizabeth; Dixon, Simon

    2015-01-01

    Objective To investigate the effect of targeted marginal annual investments by local healthcare commissioners on the outcomes they expected to achieve with these investments. Design Controlled before and after study. Setting: 152 commissioning organisations (primary care trusts) in England. Methods National surveys of commissioning managers in 2009 and 2010 to identify: the largest marginal investments made in four key conditions/services (diabetes, coronary heart disease, chronic pulmonary airways disease and emergency and urgent care) in 2008/2009 and 2009/2010; the outcomes commissioners expected to achieve with these investments; and the processes commissioners used to develop these investments. Collation of routinely available data on outcomes commissioners expected from these investments over the period 2007/2008 to 2010/2011. Results 51% (77/152) of commissioners agreed to participate in the survey in 2009 and 60% (91/152) in 2010. Around half reported targeted marginal investments in each condition/service each year. Routine data on many of the outcomes they expected to achieve through these investments were not available. Also, commissioners expected some outcomes to be achieved beyond the time scale of our study. Therefore, only a limited number of outcomes of investments were tested. Outcomes included directly standardised emergency admission rates for the four conditions/services, and the percentage of patients with diabetes with glycated haemoglobin <7. There was no evidence that targeted marginal investments reduced emergency admission rates. There was evidence of an improvement in blood glucose management for diabetes for commissioners investing to improve diabetes care but this was compromised by a change in how the outcome was measured in different years. This investment was unlikely to be cost-effective. Conclusions Commissioners made marginal investments in specific health conditions and services with the aim of improving a wide range of outcomes

  8. 76 FR 71878 - Corporate Reorganizations; Allocation of Basis in “All Cash D” Reorganizations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-21

    ... ``All Cash D'' Reorganizations AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Final and... the issuing corporation. For example, assume that J owns all the stock of corporations X and Y, and X owns all of the stock of corporation T. X has a $150 basis in the T stock. The corporations do not join...

  9. Substance Abuse. Policy Statement.

    ERIC Educational Resources Information Center

    National Collaboration for Youth, Washington, DC.

    This paper presents the policy statement on substance abuse from the National Collaboration for Youth (NCY). The policy statement section lists programs and activities supported by the NCY. A section on background includes a statement of the issue of substance abuse. Areas examined in this section include alcohol abuse and drunk driving among…

  10. School Library Policy Statement.

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education, Winnipeg. Instructional Resources Branch.

    The School Library Policy Statement for Manitoba schools begins with the mission statement of Manitoba Education and Training and the Goals of Learning for Manitoba. Statements of Manitoba's School Library Policy and the Philosophy of the School Library Program are also provided, together with an outline of the responsibilities of both Manitoba's…

  11. Compressing bitmap indices by data reorganization

    SciTech Connect

    Pinar, Ali; Tao, Tao; Ferhatosmanoglu, Hakan

    2004-07-01

    Many scientific applications generate massive volumes of data through observations or computer simulations, bringing up the need for effective indexing methods for efficient storage and retrieval of scientific data. Unlike conventional databases, scientific data is mostly read-only and its volume can reach to the order of petabytes, making a compact index structure vital. Bit map indexing has been successfully applied to scientific databases by exploiting the fact that scientific data are enumerated or numerical. Bitmap indices can be compressed with variants of run length encoding for a compact index structure. However even this may not be enough for the enormous data generated in some applications such as high energy physics. In this paper, we study how to reorganize bitmap tables for improved compression rates. Our algorithms are used just as a preprocessing step, thus there is no need to revise the current indexing techniques and the query processing algorithms. We introduce the tuple reordering problem, which aims to reorganize database tuples for optimal compression rates. We propose Gray code ordering algorithm for this NP-Complete problem, which is an in-place algorithm, and runs in linear time in the order of the size of the database. We also discuss how the tuple reordering problem can be reduced to the traveling salesperson problem. Our experimental results on real data sets show that the compression ratio can be improved by a factor of 4 to 7.

  12. 26 CFR 1.585-4 - Reorganizations and asset acquisitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 7 2011-04-01 2009-04-01 true Reorganizations and asset acquisitions. 1.585-4 Section 1.585-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Banking Institutions § 1.585-4 Reorganizations and asset...

  13. 26 CFR 1.585-4 - Reorganizations and asset acquisitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Reorganizations and asset acquisitions. 1.585-4 Section 1.585-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Banking Institutions § 1.585-4 Reorganizations and asset...

  14. 16 CFR 802.10 - Stock dividends and splits; reorganizations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Stock dividends and splits; reorganizations... INTERPRETATIONS UNDER THE HART-SCOTT-RODINO ANTITRUST IMPROVEMENTS ACT OF 1976 EXEMPTION RULES § 802.10 Stock dividends and splits; reorganizations. (a) The acquisition of voting securities pursuant to a stock split...

  15. 76 FR 26603 - Reorganization of Sector North Carolina; Technical Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ... Macon, NC, with a Marine Safety Unit (MSU) in Wilmington, NC, responsible for the Cape Fear River Marine... the Cape Fear River Marine Inspection and COTP Zones. The Coast Guard has now reorganized Sector North... Fear River Marine Inspection and COTP Zones. This reorganization is intended to improve...

  16. Subcortical functional reorganization due to early blindness.

    PubMed

    Coullon, Gaelle S L; Jiang, Fang; Fine, Ione; Watkins, Kate E; Bridge, Holly

    2015-04-01

    Lack of visual input early in life results in occipital cortical responses to auditory and tactile stimuli. However, it remains unclear whether cross-modal plasticity also occurs in subcortical pathways. With the use of functional magnetic resonance imaging, auditory responses were compared across individuals with congenital anophthalmia (absence of eyes), those with early onset (in the first few years of life) blindness, and normally sighted individuals. We find that the superior colliculus, a "visual" subcortical structure, is recruited by the auditory system in congenital and early onset blindness. Additionally, auditory subcortical responses to monaural stimuli were altered as a result of blindness. Specifically, responses in the auditory thalamus were equally strong to contralateral and ipsilateral stimulation in both groups of blind subjects, whereas sighted controls showed stronger responses to contralateral stimulation. These findings suggest that early blindness results in substantial reorganization of subcortical auditory responses. Copyright © 2015 the American Physiological Society.

  17. Postural reorganization induced by torso cutaneous covibration.

    PubMed

    Lee, Beom-Chan; Martin, Bernard J; Ho, Allison; Sienko, Kathleen H

    2013-05-01

    Cutaneous information from joints has been attributed proprioceptive properties similar to those of muscle spindles. This study aimed to assess whether vibration-induced changes in torso cutaneous information contribute to whole-body postural reorganization in humans. Ten healthy young adults stood in normal and Romberg stances with six vibrating actuators positioned on the torso in contact with the skin over the left and right external oblique, internal oblique, and erector spinae muscle locations at the L4/L5 vertebrae level. Vibrations around the torso were randomly applied at two locations simultaneously (covibration) or at all locations simultaneously. Kinematic analysis of the body segments indicated that covibration applied to the skin over the internal oblique muscles induced shifts of both the head and torso in the anterior direction (torso flexion) while the hips shifted in the posterior direction (ankle plantar flexion). Conversely, covibration applied to the skin over the erector spinae muscle locations produced opposite effects. However, covibration applied to the skin over the left internal oblique and left erector spinae, the right internal oblique and right erector spinae, or at all locations simultaneously did not induce any significant postural changes. In addition, the center of pressure position as measured by the force plate was unaffected by all covibration conditions tested. These results were independent of stance and suggest an integrated and coordinated reorganization of posture in response to vibration-induced changes in cutaneous information. In addition, combinations of vibrotactile stimuli over multiple locations exhibit directional summation properties in contrast to the individual responses we observed in our previous work.

  18. Language organization and reorganization in epilepsy

    PubMed Central

    Hamberger, Marla J.; Cole, Jeffrey

    2011-01-01

    The vast majority of healthy individuals are left hemisphere dominant for language; however, individuals with left hemisphere epilepsy have a higher likelihood of atypical language organization. The cerebral organization of language in epilepsy has been studied with invasive procedures such as Wada testing and electrical cortical stimulation mapping (ESM), and more recently, with noninvasive neuroimaging techniques such as functional magnetic resonance imaging (fMRI). Investigators have used these techniques to explore the influence of unique clinical features inherent in epilepsy that might contribute to the reorganization of language, such as location of seizure onset, age of seizure onset, and extent of interictal epileptiform activity. In this paper, we review the contribution of these and other clinical variables to the lateralization and localization of language in epilepsy, and how these patient-related variables affect the results from these three different, yet complementary methodologies. Unlike the abrupt language changes that occur following acute brain injury with disruption of established language circuits, converging evidence suggests that the chronic nature of epileptic activity can result in a developmental shift of language from the left to the right hemisphere or re-routing of language pathways from traditional to non-traditional areas within the dominant left hemisphere. Clinical variables have been shown to contribute to cerebral language reorganization in the setting of chronic seizure disorders, yet such factors have not been reliable predictors of altered language networks in individual patients, underscoring the need for language lateralization and localization procedures when definitive identification of language cortex is necessary for clinical care. PMID:21842185

  19. Reorganization of School Units. Bulletin, 1935, No. 15

    ERIC Educational Resources Information Center

    Cook, Katherine M., Comp.

    1936-01-01

    This bulletin reports the findings of a conference of school officials called by the U.S. Commissioner of Education, Dr. J. W. Studebaker, in the Office of Education, June 17, 18, and 19, 1935. Attending this conference, and contributing to the sections of this bulletin were: Howard A. Dawson, J. Cayce Morrison, Edgar L. Morphet, D. H. Sutton,…

  20. Technology evaluation report: Toronto Harbour Commissioners (THC) soil recycle treatment train

    SciTech Connect

    Ehrenreich, L.C.; Matuson, A.; Peters, J.; Evans, J.

    1993-07-01

    The report summarizes the results and activities of the demonstration testing of Toronto Harbor Commissioners (THC) Soil Recycle Treatment Train. The Demonstration was conducted at a site within the Port Industrial District (PID) in Toronto, Ontario, Canada under the Superfund Innovative Technology Evaluation (SITE) Program developed by the US Environmental Protection Agency (EPA). The demonstration examined a part of THC's on-going evaluation of the treatment train during the first nine months of 1992. EPA elected to sample the process during the processing of Soil B, which based on field sampling, was expected to exhibit relatively high organic (oil and grease, s) and inorganic (heavy metals) contaminants.

  1. The "5Rs of Reorganization": A Case Report on Service Delivery Reorganization within a Pediatric Rehabilitation Organization.

    PubMed

    Phoenix, Michelle; Rosenbaum, Peter; Watson, Denise; Camden, Chantal

    2016-01-01

    Pediatric rehabilitation centers constantly reorganize services to accommodate changes in funding, client needs, evidence-based practices, accountability requirements, theoretical models, and values. However, there are few service delivery models or descriptions of how organizations plan for change to guide organizations through this complex task. This case report presents the "5Rs of Reorganization," a novel process for planning service delivery reorganization projects in pediatric rehabilitation centers. The 5Rs include: 1. Recognize the need for change, 2. Reallocate resources for project management, 3. Review the reality of clients, service delivery, and the community, 4. Reconstruct reality, and 5. Report results. The implementation and outcomes of the "5Rs of Reorganization" process are described for one pediatric rehabilitation center to illustrate how use of this process led to effective service delivery reorganization planning. The resulting multi-component customized service delivery plan reflects high levels of stakeholder involvement. Principles of project management can be applied to support service delivery reorganization planning within pediatric rehabilitation centers using the "5Rs of Reorganization." Strong communication throughout the planning phase is key to developing and sharing a plan for service delivery reorganization. Communication can be supported through use of the 5R process.

  2. Toronto Harbour Commissioners (THC) soil recycle treatment train. Applications analysis report

    SciTech Connect

    Ehrenreich, L.C.; Matuson, A.; Peters, J.; Evans, J.

    1993-04-01

    This project consists of a demonstration of the Toronto Harbour Commissioners (THC) Soil Recycle Treatment Train. The treatment train consists of three processes. The first process utilizes an attrition soil wash process to separate relatively uncontaminated soil from a more heavily contaminated fine slurry. The contaminated fine slurry is then further processed in a metals removal process or a bioslurry reactor process or both to remove organic contaminants and heavy metals contamination. The Toronto Harbour Commissioners conducted a long-term evaluation of this treatment train at a 55 tons per day pilot plant at 185 Cherry Street in the port of Toronto, located in Toronto, Ontario, Canada. The Superfund Innovative Technology Evaluation (SITE) Program conducted a demonstration project that examined in detail the processing of soil from one of the sites being evaluated in the overall project. The goals of this study were to evaluate the technical effectiveness and economics of a treatment process sequence and to assess the potential applicability of the process to other wastes and/or other Superfund and hazardous waste sites.

  3. The role of ocean-atmosphere reorganizations in glacial cycles

    NASA Astrophysics Data System (ADS)

    Broecker, Wallace S.; Denton, George H.

    A case is made that glacial-to-interglacial transitions involve major reorganizations of the ocean-atmosphere system. Such reorganizations constitute jumps between stable modes of operation which cause changes in the greenhouse gas content and albedo of the atmosphere. Only in this way can the rapidity of glacial terminations, the hemispheric synchroneity and symmetry of mountain glaciation, and the large polar air temperature and dustiness variations be accounted for. If these reorganizations are driven in some fashion by orbitally induced seasonal insolation changes, then the connection between insolation and climate is most likely through impacts of fresh water transport on the ocean's salinity distribution.

  4. The role of ocean-atmosphere reorganizations is glacial cycles

    NASA Astrophysics Data System (ADS)

    Broecker, Wallace S.; Denton, George H.

    1989-10-01

    A case is made that glacial-to-interglacial transitions involve major reorganizations of the ocean-atmosphere system. Such reorganizations constitute jumps between stable modes of operation which cause changes in the greenhouse gas content and albedo of the atmosphere. Only in this way can the rapidity of glacial terminations, the hemispheric synchroneity and symmetry of mountain glaciation, and the large polar air temperature and dustiness variations be accounted for. If these reorganizations are driven in some fashion by orbitally induced seasonal insolation changes, then the connection between insolation and climate is most likely through impacts of fresh water transport on the ocean's salinity distribution.

  5. Reorganization of human cortical maps caused by inherited photoreceptor abnormalities.

    PubMed

    Baseler, Heidi A; Brewer, Alyssa A; Sharpe, Lindsay T; Morland, Antony B; Jägle, Herbert; Wandell, Brian A

    2002-04-01

    We describe a compelling demonstration of large-scale developmental reorganization in the human visual pathways. The developmental reorganization was observed in rod monochromats, a rare group of congenitally colorblind individuals who virtually lack cone photoreceptor function. Normal controls had a cortical region, spanning several square centimeters, that responded to signals initiated in the all-cone foveola but was inactive under rod viewing conditions; in rod monochromats this cortical region responded powerfully to rod-initiated signals. The measurements trace a causal pathway that begins with a genetic anomaly that directly influences sensory cells and ultimately results in a substantial central reorganization.

  6. Compensatory neural reorganization in Tourette syndrome.

    PubMed

    Jackson, Stephen R; Parkinson, Amy; Jung, Jeyoung; Ryan, Suzanne E; Morgan, Paul S; Hollis, Chris; Jackson, Georgina M

    2011-04-12

    Children with neurological disorders may follow unique developmental trajectories whereby they undergo compensatory neuroplastic changes in brain structure and function that help them gain control over their symptoms. We used behavioral and brain imaging techniques to investigate this conjecture in children with Tourette syndrome (TS). Using a behavioral task that induces high levels of intermanual conflict, we show that individuals with TS exhibit enhanced control of motor output. Then, using structural (diffusion-weighted imaging) brain imaging techniques, we demonstrate widespread differences in the white matter (WM) microstructure of the TS brain that include alterations in the corpus callosum and forceps minor (FM) WM that significantly predict tic severity in TS. Most importantly, we show that task performance for the TS group (but not for controls) is strongly predicted by the WM microstructure of the FM pathways that lead to the prefrontal cortex and by the functional magnetic resonance imaging blood oxygen level-dependent response in prefrontal areas connected by these tracts. These results provide evidence for compensatory brain reorganization that may underlie the increased self-regulation mechanisms that have been hypothesized to bring about the control of tics during adolescence.

  7. Reorganization of the human central nervous system.

    PubMed

    Schalow, G; Zäch, G A

    2000-10-01

    The key strategies on which the discovery of the functional organization of the central nervous system (CNS) under physiologic and pathophysiologic conditions have been based included (1) our measurements of phase and frequency coordination between the firings of alpha- and gamma-motoneurons and secondary muscle spindle afferents in the human spinal cord, (2) knowledge on CNS reorganization derived upon the improvement of the functions of the lesioned CNS in our patients in the short-term memory and the long-term memory (reorganization), and (3) the dynamic pattern approach for re-learning rhythmic coordinated behavior. The theory of self-organization and pattern formation in nonequilibrium systems is explicitly related to our measurements of the natural firing patterns of sets of identified single neurons in the human spinal premotor network and re-learned coordinated movements following spinal cord and brain lesions. Therapy induced cell proliferation, and maybe, neurogenesis seem to contribute to the host of structural changes during the process of re-learning of the lesioned CNS. So far, coordinated functions like movements could substantially be improved in every of the more than 100 patients with a CNS lesion by applying coordination dynamic therapy. As suggested by the data of our patients on re-learning, the human CNS seems to have a second integrative strategy for learning, re-learning, storing and recalling, which makes an essential contribution of the functional plasticity following a CNS lesion. A method has been developed by us for the simultaneous recording with wire electrodes of extracellular action potentials from single human afferent and efferent nerve fibres of undamaged sacral nerve roots. A classification scheme of the nerve fibres in the human peripheral nervous system (PNS) could be set up in which the individual classes of nerve fibres are characterized by group conduction velocities and group nerve fibre diameters. Natural impulse patterns

  8. Methylphenidate modulates cerebral post-stroke reorganization.

    PubMed

    Tardy, Jean; Pariente, Jérémie; Leger, Anne; Dechaumont-Palacin, Sophie; Gerdelat, Angélique; Guiraud, Vincent; Conchou, Fabrice; Albucher, Jean-François; Marque, Philippe; Franceries, Xavier; Cognard, Christophe; Rascol, Olivier; Chollet, François; Loubinoux, Isabelle

    2006-11-15

    We hypothesized that a single dose of methylphenidate (MP) would modulate cerebral motor activation and behavior in patients having suffered a subcortical stroke. Eight men with a single stroke on the corticospinal tract resulting in a pure motor hemiparesia were included in a randomized, cross-over, double-blind, placebo-controlled study. Patients were first evaluated 17 days after stroke onset by validated neurological scales, motor tests and fMRI (flexion/extension of the digits) after 20 mg MP or placebo. Seven days later, the patients underwent the same protocol and received the drug they had not taken at the first evaluation. Each patient was his own control. Placebo intake did not change performance. MP compared to placebo elicited a significant improvement in motor performance of the affected hand at the finger tapping test. MP induced: (1) a hyperactivation of the ipsilesional primary sensorimotor cortex including the motor hand and face areas and of the contralesional premotor cortex; (2) a hypoactivation of the ipsilesional anterior cingulum. Hyperactivation in the face motor area correlated positively with the improvement in performance. We demonstrated that the reorganized network may efficiently be targeted by the drug and that the effect of MP might partly rely on an improvement in attention/effort through cingulum modulation.

  9. Do marginal investments made by NHS healthcare commissioners in the UK produce the outcomes they hope to achieve? Observational study.

    PubMed

    O'Cathain, Alicia; Sampson, Fiona; Strong, Mark; Pickin, Mark; Goyder, Elizabeth; Dixon, Simon

    2015-11-06

    To investigate the effect of targeted marginal annual investments by local healthcare commissioners on the outcomes they expected to achieve with these investments. Controlled before and after study. 152 commissioning organisations (primary care trusts) in England. National surveys of commissioning managers in 2009 and 2010 to identify: the largest marginal investments made in four key conditions/services (diabetes, coronary heart disease, chronic pulmonary airways disease and emergency and urgent care) in 2008/2009 and 2009/2010; the outcomes commissioners expected to achieve with these investments; and the processes commissioners used to develop these investments. Collation of routinely available data on outcomes commissioners expected from these investments over the period 2007/2008 to 2010/2011. 51% (77/152) of commissioners agreed to participate in the survey in 2009 and 60% (91/152) in 2010. Around half reported targeted marginal investments in each condition/service each year. Routine data on many of the outcomes they expected to achieve through these investments were not available. Also, commissioners expected some outcomes to be achieved beyond the time scale of our study. Therefore, only a limited number of outcomes of investments were tested. Outcomes included directly standardised emergency admission rates for the four conditions/services, and the percentage of patients with diabetes with glycated haemoglobin <7. There was no evidence that targeted marginal investments reduced emergency admission rates. There was evidence of an improvement in blood glucose management for diabetes for commissioners investing to improve diabetes care but this was compromised by a change in how the outcome was measured in different years. This investment was unlikely to be cost-effective. Commissioners made marginal investments in specific health conditions and services with the aim of improving a wide range of outcomes. There was little evidence of impact on the limited

  10. Teaching Philosophy Statements

    ERIC Educational Resources Information Center

    Faryadi, Qais

    2015-01-01

    This article examines the rationale for my teaching philosophy. Using a personal perspective, I explain my objectives, mission, and vision in writing my philosophy of teaching statements. This article also creates a road map and reference points for educators who want to write their own teaching philosophy statements to help them make informed…

  11. Drug Free Campus Statement.

    ERIC Educational Resources Information Center

    Casper Coll., WY.

    These three brief documents, a policy statement, a summary of pertinent laws on alcohol and illegal drugs, and a substance addiction specialist curriculum description, taken together describe the Casper College (Wyoming) drug and alcohol abuse prevention program. The policy statement briefly summarizes the health risks associated with drug and…

  12. The Indian Reorganization Act and the Cheyenne River Sioux

    ERIC Educational Resources Information Center

    Ducheneaux, Frank

    1976-01-01

    Describing the history of the Cheyenne River Sioux Constitution as established under the Indian Reorganization Act of 1934, this article presents a section by section analysis of the Sioux Constitution and the text of that constitution as well. (JC)

  13. Administrative Control in Academic Departments and Response to Reorganization

    ERIC Educational Resources Information Center

    Ryan, Doris W.

    1970-01-01

    Studies the response of 15 academic departments at Ohio State University to reorganization. Implications of the study deal with methods of introducing change, the importance of group norms, and the link between informal norms and existing formal structure. (MK)

  14. Reorganization of the Yearbook Staffs for the 1980s.

    ERIC Educational Resources Information Center

    Vossen, Daniel L.

    1981-01-01

    A diagram of the reorganized yearbook staff, reflective of current emphasis on magazine-style layout designs, and adaptable for colleges, high schools, mid-high schools, and junior high schools. Listings of responsibilities for each integral staff member. (RL)

  15. Cortical reorganization after spinal cord injury: always for good?

    PubMed Central

    Moxon, Karen A.; Oliviero, Antonio; Aguilar, Juan; Foffani, Guglielmo

    2015-01-01

    Plasticity constitutes the basis of behavioral changes as a result of experience. It refers to neural network shaping and re-shaping at the global level and to synaptic contacts remodeling at the local level, either during learning or memory encoding, or as a result of acute or chronic pathological conditions. ‘Plastic’ brain reorganization after central nervous system lesions has a pivotal role in the recovery and rehabilitation of sensory and motor dysfunction, but can also be “maladaptive”. Moreover, it is clear that brain reorganization it is not a “static” phenomenon but rather a very dynamic process. Spinal cord injury immediately initiates a change in brain state and starts cortical reorganization. In the long term, the impact of injury – with or without accompanying therapy – on the brain is a complex balance between supraspinal reorganization and spinal recovery. The degree of cortical reorganization after spinal cord injury is highly variable, and can range from no reorganization (i.e. “silencing”) to massive cortical remapping. This variability critically depends on the species, the age of the animal when the injury occurs, the time after the injury has occurred, and the behavioral activity and possible therapy regimes after the injury. We will briefly discuss these dependencies, trying to highlight their translational value. Overall, it is not only necessary to better understand how the brain can reorganize after injury with or without therapy, it is also necessary to clarify when and why brain reorganization can be either “good” or “bad” in terms of its clinical consequences. This information is critical in order to develop and optimize cost-effective therapies to maximize functional recovery while minimizing maladaptive states after spinal cord injury. PMID:24997269

  16. Taxonomic reorganization of the family Bornaviridae

    PubMed Central

    Kuhn, Jens H.; Dürrwald, Ralf; Bào, Yīmíng; Briese, Thomas; Carbone, Kathryn; Clawson, Anna N.; deRisi, Joseph L.; Garten, Wolfgang; Jahrling, Peter B.; Kolodziejek, Jolanta; Rubbenstroth, Dennis; Schwemmle, Martin; Stenglein, Mark; Tomonaga, Keizo; Weissenböck, Herbert; Nowotny, Norbert

    2014-01-01

    Knowledge of bornaviruses has expanded considerably during the last decade. A possible reservoir of mammalian Borna disease virus has been identified, divergent bornaviruses have been detected in birds and reptiles, and endogenous bornavirus-like elements have been discovered in the genomes of vertebrates of several species. Previous sequence comparisons and alignments have indicated that the members of the current family Bornaviridae are phylogenetically diverse and are not adequately classified in the existing bornavirus taxonomy supported by the International Committee on Taxonomy of Viruses (ICTV). We provide an update of these analyses and describe their implications for taxonomy. We propose retaining the family name Bornaviridae and the genus Bornavirus but reorganizing species classification. PAirwise Sequence Comparison (PASC) of bornavirus genomes and Basic Local Alignment Search Tool (BLAST) comparison of genomic and protein sequences, in combination with other already published phylogenetic analyses and known biological characteristics of bornaviruses, indicate that this genus should include at least five species: Mammalian 1 bornavirus (classical Borna disease virus and divergent Borna disease virus isolate No/98), Psittaciform 1 bornavirus (avian/psittacine bornaviruses 1, 2, 3, 4, 7), Passeriform 1 bornavirus (avian/canary bornaviruses C1, C2, C3, LS), Passeriform 2 bornavirus (estrildid finch bornavirus EF), and Waterbird 1 bornavirus (avian bornavirus 062CG). This classification is also in line with biological characteristics of these viruses and their vertebrate hosts. A snake bornavirus, proposed to be named Loveridge’s garter snake virus 1, should be classified as a member of an additional species (Elapid 1 bornavirus), unassigned to a genus, in the family Bornaviridae. Avian bornaviruses 5, 6, MALL, and another “reptile bornavirus” (“Gaboon viper virus”) should stay unclassified until further information becomes available. Finally, we

  17. Draft Regulations for the Comprehensive Public School Building Safety Program. Amendment to Regulations of the Commissioner of Education.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany. Office of Facilities Planning.

    The New York State Department of Education provides the amendments to regulations of the Commissioner of Education concerning the Comprehensive Public School Building Safety Program effective May 7, 1999. Amended items include those involving the school district 5-year capital assets preservation facilities plan, building inspections, construction…

  18. 77 FR 1483 - Commissioners of Public Works of the City of Spartanburg, SC; Notice of Availability of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Commissioners of Public Works of the City of Spartanburg, SC; Notice of Availability of Environmental Assessment In accordance with the National Environmental Policy Act of 1969 and...

  19. 20 CFR 403.140 - If the Commissioner authorizes testimony, what will be the scope and form of that testimony?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., what will be the scope and form of that testimony? 403.140 Section 403.140 Employees' Benefits SOCIAL... PROCEEDINGS § 403.140 If the Commissioner authorizes testimony, what will be the scope and form of that... declaration rather than a deposition and a deposition rather than trial testimony. ...

  20. 20 CFR 403.140 - If the Commissioner authorizes testimony, what will be the scope and form of that testimony?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., what will be the scope and form of that testimony? 403.140 Section 403.140 Employees' Benefits SOCIAL... PROCEEDINGS § 403.140 If the Commissioner authorizes testimony, what will be the scope and form of that... declaration rather than a deposition and a deposition rather than trial testimony. ...

  1. 20 CFR 403.140 - If the Commissioner authorizes testimony, what will be the scope and form of that testimony?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., what will be the scope and form of that testimony? 403.140 Section 403.140 Employees' Benefits SOCIAL... PROCEEDINGS § 403.140 If the Commissioner authorizes testimony, what will be the scope and form of that... declaration rather than a deposition and a deposition rather than trial testimony. ...

  2. 20 CFR 403.140 - If the Commissioner authorizes testimony, what will be the scope and form of that testimony?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., what will be the scope and form of that testimony? 403.140 Section 403.140 Employees' Benefits SOCIAL... PROCEEDINGS § 403.140 If the Commissioner authorizes testimony, what will be the scope and form of that... declaration rather than a deposition and a deposition rather than trial testimony. ...

  3. 20 CFR 403.140 - If the Commissioner authorizes testimony, what will be the scope and form of that testimony?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., what will be the scope and form of that testimony? 403.140 Section 403.140 Employees' Benefits SOCIAL... PROCEEDINGS § 403.140 If the Commissioner authorizes testimony, what will be the scope and form of that... declaration rather than a deposition and a deposition rather than trial testimony. ...

  4. The Canadian Human Rights Commission and Issues of Concern for Aboriginal Women. Notes for Remarks, by the Deputy Chief Commissioner.

    ERIC Educational Resources Information Center

    Falardeau-Ramsay, Michelle

    This speech by the deputy chief commissioner of the Canadian Human Rights Commission discusses human rights, employment security, and pay-equity issues for Native Canadian women. The speech, offered in both English and French, calls the inequality of opportunity for Native Canadians a "national tragedy." It describes efforts to bring…

  5. Community School Board Elections in New York City. A Report to the New York State Commissioner of Education.

    ERIC Educational Resources Information Center

    Rubin, Max J.

    Following reports of irregularities in the May 1973 school board elections of New York City, the New York Commissioner of Education asked the author to identify the difficulties encountered by the voters and candidates, on both election day and in the period for registration and nomination which preceded it, and to recommend such changes in the…

  6. 20 CFR 408.1060 - What happens if a Federal Court remands your case to the Commissioner?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What happens if a Federal Court remands your case to the Commissioner? 408.1060 Section 408.1060 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Determinations and the Administrative Review...

  7. 43 CFR 417.5 - Duties of the Commissioner of Indian Affairs with respect to Indian reservations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... IMPLEMENTING COLORADO RIVER WATER CONSERVATION MEASURES WITH LOWER BASIN CONTRACTORS AND OTHERS § 417.5 Duties... diversion, delivery, distribution and use of Colorado River water, the Commissioner shall, within the limits... each reservation, the amount and rate of return flows to the river, municipal water requirements,...

  8. 43 CFR 417.5 - Duties of the Commissioner of Indian Affairs with respect to Indian reservations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... IMPLEMENTING COLORADO RIVER WATER CONSERVATION MEASURES WITH LOWER BASIN CONTRACTORS AND OTHERS § 417.5 Duties... diversion, delivery, distribution and use of Colorado River water, the Commissioner shall, within the limits... each reservation, the amount and rate of return flows to the river, municipal water requirements,...

  9. Index to the Reports of the Commissioner of Education: 1867-1907. Bulletin, 1909, No. 7. Whole Number 407

    ERIC Educational Resources Information Center

    United States Bureau of Education, Department of the Interior, 1909

    1909-01-01

    What is presented in this bulletin is the first essay in the history of the Bureau of Education toward a comprehensive index of the annual reports of the Commissioner. It includes authors and subjects with an analysis of the more important articles, for the years 1876 to 1907, inclusive. [Best copy available has been provided.

  10. 20 CFR 403.130 - What factors may the Commissioner consider in determining whether SSA will grant your application...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... determining whether SSA will grant your application for testimony? 403.130 Section 403.130 Employees' Benefits... LEGAL PROCEEDINGS § 403.130 What factors may the Commissioner consider in determining whether SSA will grant your application for testimony? In deciding whether to authorize the testimony of an SSA employee...

  11. 20 CFR 403.130 - What factors may the Commissioner consider in determining whether SSA will grant your application...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... determining whether SSA will grant your application for testimony? 403.130 Section 403.130 Employees' Benefits... LEGAL PROCEEDINGS § 403.130 What factors may the Commissioner consider in determining whether SSA will grant your application for testimony? In deciding whether to authorize the testimony of an SSA employee...

  12. The Canadian Human Rights Commission and Issues of Concern for Aboriginal Women. Notes for Remarks, by the Deputy Chief Commissioner.

    ERIC Educational Resources Information Center

    Falardeau-Ramsay, Michelle

    This speech by the deputy chief commissioner of the Canadian Human Rights Commission discusses human rights, employment security, and pay-equity issues for Native Canadian women. The speech, offered in both English and French, calls the inequality of opportunity for Native Canadians a "national tragedy." It describes efforts to bring…

  13. 45 CFR 1321.21 - Submission of the State plan or plan amendment to the Commissioner for approval.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 4 2013-10-01 2013-10-01 false Submission of the State plan or plan amendment to the Commissioner for approval. 1321.21 Section 1321.21 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  14. 45 CFR 1321.21 - Submission of the State plan or plan amendment to the Commissioner for approval.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Submission of the State plan or plan amendment to the Commissioner for approval. 1321.21 Section 1321.21 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  15. 45 CFR 1321.21 - Submission of the State plan or plan amendment to the Commissioner for approval.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Submission of the State plan or plan amendment to the Commissioner for approval. 1321.21 Section 1321.21 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  16. 45 CFR 1321.21 - Submission of the State plan or plan amendment to the Commissioner for approval.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false Submission of the State plan or plan amendment to the Commissioner for approval. 1321.21 Section 1321.21 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  17. 45 CFR 1321.21 - Submission of the State plan or plan amendment to the Commissioner for approval.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Submission of the State plan or plan amendment to the Commissioner for approval. 1321.21 Section 1321.21 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  18. 75 FR 42747 - Smart Grid Update; Notice of Commissioner and Staff Attendance at FERC/NARUC Collaborative on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ... Energy Regulatory Commission Smart Grid Update; Notice of Commissioner and Staff Attendance at FERC/NARUC Collaborative on Smart Response Meeting July 15, 2010. The Federal Energy Regulatory Commission hereby gives.../NARUC Collaborative on Smart Response: Sacramento Convention Center, 1400 J Street, Sacramento, CA 95814...

  19. 75 FR 8190 - Art Advisory Panel of the Commissioner of Internal Revenue Service

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... Art Advisory Panel. SUMMARY: It is in the public interest to continue the existence of the Art.... Statement of Public Interest. It is in the public interest to continue the existence of the Art...

  20. 77 FR 13389 - Art Advisory Panel of the Commissioner of Internal Revenue

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-06

    ... Panel. SUMMARY: It is in the public interest to continue the existence of the Art Advisory Panel. The.... Statement of Public Interest. It is in the public interest to continue the existence of the Art...

  1. DSCOVR Public Release Statement

    Atmospheric Science Data Center

    2016-11-23

    ... DSCOVR Public Release Statement Wednesday, July 20, 2016 The Deep Space Climate Observatory (DSCOVR) is a ... is limited to the near infrared solar reflected signal. The fourth detector is a high signal-to-noise photodiode spanning UV, Visible, and ...

  2. Aljoya Consensus Statement

    EPA Pesticide Factsheets

    A consensus statement of 100 experts meeting at the Aljoya Conference Center in Seattle, Washington in July 2000 for the First International Conference on Trans-Pacific Transport of Atmospheric Contaminants.

  3. Statement on Human Cloning

    MedlinePlus

    ... form Search American Association for the Advancement of Science Statement on Human Cloning Tweet The American Association for the Advancement of Science (AAAS) recognizes the intense debates within our society ...

  4. Statement on Human Cloning

    MedlinePlus

    ... form Search American Association for the Advancement of Science Statement on Human Cloning Tweet The American Association for the Advancement of Science (AAAS) recognizes the intense debates within our society ...

  5. Environmental Impact Statements Defended

    ERIC Educational Resources Information Center

    Chemical and Engineering News, 1976

    1976-01-01

    Discusses a government report that claims that government decision making has improved since federal agencies have been required to submit any proposed action in the form of an environmental impact statement for comments by the public and other agencies. (MLH)

  6. Excitation and inhibition jointly regulate cortical reorganization in adult rats.

    PubMed

    Benali, Alia; Weiler, Elke; Benali, Youssef; Dinse, Hubert R; Eysel, Ulf T

    2008-11-19

    The primary somatosensory cortex (SI) retains its capability for cortical reorganization after injury or differential use into adulthood. The plastic response of SI cells to peripheral stimulation is characterized by extension of cortical representations accompanied by changes of the receptive field size of neurons. We used intracortical microstimulation that is known to enforce local, intracortical synchronous activity, to induce cortical reorganization and applied immunohistochemical methods in the same individual animals to investigate how plasticity in the cortical topographic maps is linked to changes in the spatial layout of the inhibitory and excitatory neurotransmitter systems. The results reveal a differential spatiotemporal pattern of upregulation and downregulation of specific factors for an excitatory (glutamatergic) and an inhibitory (GABAergic) system, associated with changes of receptive field size and reorganization of the somatotopic map in the rat SI. Predominantly local mechanisms are the specific reduction of the calcium-binding protein parvalbumin in inhibitory neurons and the low expression of the activity marker c-Fos. Reorganization in the hindpaw representation and in the adjacent SI cortical areas (motor cortex and parietal cortex) is accompanied by a major increase of the excitatory transmitter glutamate and c-Fos. The spatial extent of the reorganization appears to be limited by an increase of glutamic acid decarboxylase and the inhibitory transmitter GABA. The local and medium-range net effects are excitatory and can facilitate receptive field enlargements and cortical map expansion. The longer-range increase of inhibition appears suited to limit these effects and to prevent neurons from pathological hyperexcitability.

  7. Rotational reorganization of doped cholesteric liquid crystalline films.

    PubMed

    Eelkema, Rienk; Pollard, Michael M; Katsonis, Nathalie; Vicario, Javier; Broer, Dirk J; Feringa, Ben L

    2006-11-08

    In this paper an unprecedented rotational reorganization of cholesteric liquid crystalline films is described. This rotational reorganization results from the conversion of a chiral molecular motor dopant to an isomer with a different helical twisting power, leading to a change in the cholesteric pitch. The direction of this reorganization is correlated to the sign of the change in helical twisting power of the dopant. The rotational reorganization of the liquid crystalline film was used to rotate microscopic objects 4 orders of magnitude larger than the bistable dopants in the film, which shows that molecular motors and switches can perform work. The surface of the doped cholesteric liquid crystalline films was found to possess a regular surface relief, whose periodicity coincides with typical cholesteric polygonal line textures. These surface features originate from the cholesteric superstructure in the liquid crystalline film, which in turn is the result of the presence of the chiral dopant. As such, the presence of the dopant is expressed in these distinct surface structures. A possible mechanism at the origin of the rotational reorganization of liquid crystalline films and the cholesteric surface relief is discussed.

  8. Time to reorganize federal Earth system science and technology?

    NASA Astrophysics Data System (ADS)

    Kisslinger, Carl

    My usual reaction to plans to reorganize activities in the federal government is that these are the last resort of a bureaucrat who is faced with a tough problem and has no idea how to solve it. However, this may be the time to consider seriously a reorganization that would assemble key elements of Earth-oriented science and technology into a single federal agency. This is not a new idea, as proposals to achieve this goal have been formulated in the past and wiring diagrams for a new agency have been developed. These proposals have faded away in the face of resistance to substantial structural change that characterizes the federal bureaucracy.

  9. RTI v medical ethics: some questions arising from the recent decision of the Chief Information Commissioner under the RTI Act.

    PubMed

    Nair, M R Hariharan

    2015-01-01

    Medical ethics attaches the utmost priority to the confidentiality of medical records. Hence, the decision of the Chief Information Commissioner (CIC) rendered on April 10, 2015 in Case No: CIC/KY/A/2014/001348SA Ms Jyoti Jeena v. PIO, Institute of Human Behaviour & Allied Science (hereinafter referred to as Jyoti Jeena), that the wife-applicant is entitled to get copies of the medical records of her estranged husband has raised many eyebrows.

  10. 26 CFR 601.503 - Requirements of power of attorney, signatures, fiduciaries and Commissioner's authority to...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 20 2013-04-01 2013-04-01 false Requirements of power of attorney, signatures... STATEMENT OF PROCEDURAL RULES Conference and Practice Requirements § 601.503 Requirements of power of...) Requirements. A power of attorney must contain the following information— (1) Name and mailing address of...

  11. 26 CFR 601.503 - Requirements of power of attorney, signatures, fiduciaries and Commissioner's authority to...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 20 2011-04-01 2011-04-01 false Requirements of power of attorney, signatures... STATEMENT OF PROCEDURAL RULES Conference and Practice Requirements § 601.503 Requirements of power of...) Requirements. A power of attorney must contain the following information— (1) Name and mailing address of...

  12. 26 CFR 601.503 - Requirements of power of attorney, signatures, fiduciaries and Commissioner's authority to...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 20 2010-04-01 2010-04-01 false Requirements of power of attorney, signatures... STATEMENT OF PROCEDURAL RULES Conference and Practice Requirements § 601.503 Requirements of power of...) Requirements. A power of attorney must contain the following information— (1) Name and mailing address of...

  13. 20 CFR 410.691 - Referral to the Deputy Commissioner for Programs and Policy, or his or her designee, for hearing...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK..., Finality of Decisions, and Representation of Parties § 410.691 Referral to the Deputy Commissioner...

  14. Position Statements, Issue Briefs, Resolutions and Consensus Statements. Revised

    ERIC Educational Resources Information Center

    National Association of School Nurses (NJ1), 2012

    2012-01-01

    This article presents position statements, issue briefs, and resolutions and consensus statements of the National Association of School Nurses (NASN). The Position Statements include: (1) Allergy/Anaphylaxis Management in the School Setting; (2) Caseload Assignments; (3) Child Mortality in the School Setting; (4) Chronic Health Conditions, Managed…

  15. Rural School District Reorganization on the Great Plains.

    ERIC Educational Resources Information Center

    Bryant, Miles

    2002-01-01

    Rural school district reorganization and school consolidation are put into perspective by reviewing the large population increases that fueled small-school growth in the Great Plains, 1870-1930. Since the Dust Bowl and Great Depression, population losses, improvements in transportation, and arguments advocating economies of scale and increased…

  16. A Model for Reorganization Applying Quality Principles and Techniques.

    ERIC Educational Resources Information Center

    Brown, Lynne Branche; Stanley, Nancy Markle

    This paper chronicles ongoing alterations to the organizational structure of the acquisitions department at Pennsylvania State University using the tenets of total quality management (TQM). The movement toward reorganizing for process improvement began in late 1992 when the associate dean of libraries called the acquisitions department together to…

  17. East Texas Oilfield Schools: Expansion, Diminution and Reorganization

    ERIC Educational Resources Information Center

    LeCompte, Karon; Nicol, Tom

    2005-01-01

    This article describes the rise, diminution, and reorganization of East Texas Oilfield schools which was defined by the socio-economic conditions of the oil era, from the mid-nineteenth century until the third quarter of the twentieth century. Citizens of East Texas seized the opportunity at the time of oil discovery to provide superior school…

  18. Threat to Scientific Publication Seen in GPO Reorganization.

    ERIC Educational Resources Information Center

    Henig, Robin Marantz

    1979-01-01

    The controversy concerning H.R. 4572, the Public Printing Reorganization Act, is presented; the bill is scheduled to appear before Congress this month. The belief among the scientific community and publishing industry is that it will jeopardize the distribution of publications of scientists' research. (SA)

  19. REORGANIZED SCIENCE CURRICULUM, 5A, FIFTH GRADE SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE SEVENTH IN A SERIES OF 17 VOLUMES, THIS VOLUME PROVIDES THE FIFTH GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. THERE IS A DETAILED OUTLINE OF SUBJECT MATTER FOR GRADE 5 FOR EACH OF THE FOLLOWING MAJOR AREAS AROUND…

  20. Chinese and English Infants' Tone Perception: Evidence for Perceptual Reorganization

    ERIC Educational Resources Information Center

    Mattock, Karen; Burnham, Denis

    2006-01-01

    Over half the world's population speaks a tone language, yet infant speech perception research has typically focused on consonants and vowels. Very young infants can discriminate a wide range of native and nonnative consonants and vowels, and then in a process of "perceptual reorganization" over the 1st year, discrimination of most…

  1. 12 CFR 5.32 - Expedited procedures for certain reorganizations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Expedited procedures for certain reorganizations. 5.32 Section 5.32 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RULES, POLICIES, AND PROCEDURES FOR CORPORATE ACTIVITIES Expansion of Activities § 5.32 Expedited procedures for...

  2. 12 CFR 5.32 - Expedited procedures for certain reorganizations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Expedited procedures for certain reorganizations. 5.32 Section 5.32 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RULES, POLICIES, AND PROCEDURES FOR CORPORATE ACTIVITIES Expansion of Activities § 5.32 Expedited procedures for...

  3. 12 CFR 5.32 - Expedited procedures for certain reorganizations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Expedited procedures for certain reorganizations. 5.32 Section 5.32 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RULES, POLICIES, AND PROCEDURES FOR CORPORATE ACTIVITIES Expansion of Activities § 5.32 Expedited procedures for...

  4. 12 CFR 5.32 - Expedited procedures for certain reorganizations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Expedited procedures for certain reorganizations. 5.32 Section 5.32 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RULES, POLICIES, AND PROCEDURES FOR CORPORATE ACTIVITIES Expansion of Activities § 5.32 Expedited procedures for...

  5. East Texas Oilfield Schools: Expansion, Diminution and Reorganization

    ERIC Educational Resources Information Center

    LeCompte, Karon; Nicol, Tom

    2005-01-01

    This article describes the rise, diminution, and reorganization of East Texas Oilfield schools which was defined by the socio-economic conditions of the oil era, from the mid-nineteenth century until the third quarter of the twentieth century. Citizens of East Texas seized the opportunity at the time of oil discovery to provide superior school…

  6. REORGANIZED SCIENCE CURRICULUM, 4A, FOURTH GRADE SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE FIFTH IN A SERIES OF 17 VOLUMES, THIS VOLUME PROVIDES THE FOURTH GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. THERE IS A DETAILED OUTLINE OF THE CONTENT FOR GRADE 4 FOR EACH OF THE FOLLOWING MAJOR AREAS AROUND WHICH…

  7. REORGANIZED SCIENCE CURRICULUM, 7A, GRADE SEVEN SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE TWELFTH IN A SERIES OF 17 VOLUMES, THIS VOLUME PROVIDES THE SEVENTH GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. THE SEVENTH GRADE SUPPLEMENT IS IN TWO VOLUMES. VOLUME 7A CONTAINS INTRODUCTORY MATERIAL, A BRIEF…

  8. REORGANIZED SCIENCE CURRICULUM, 5A, FIFTH GRADE SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE SEVENTH IN A SERIES OF 17 VOLUMES, THIS VOLUME PROVIDES THE FIFTH GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. THERE IS A DETAILED OUTLINE OF SUBJECT MATTER FOR GRADE 5 FOR EACH OF THE FOLLOWING MAJOR AREAS AROUND…

  9. REORGANIZED SCIENCE CURRICULUM, 6A, SIXTH GRADE SUPPLEMENT.

    ERIC Educational Resources Information Center

    Minneapolis Special School District 1, Minn.

    THE NINTH IN A SERIES OF 17 VOLUMES, THIS VOLUME PROVIDES THE SIXTH GRADE TEACHER WITH A GUIDE TO THE REORGANIZED SCIENCE CURRICULUM OF THE MINNEAPOLIS PUBLIC SCHOOLS. THE MATERIALS ARE INTENDED TO BE AUGMENTED AND REVISED AS THE NEED ARISES. THE SIXTH GRADE SUPPLEMENT IS IN THREE VOLUMES. VOLUME 6A HAS A DETAILED OUTLINE OF THE SUBJECT MATTER FOR…

  10. The Implications of Structural Reorganization in an Emerging Research Institution.

    ERIC Educational Resources Information Center

    Bjork, Lars G.

    Structural reorganization was investigated as one factor associated with the development of the University of New Mexico from an undergraduate teaching institution toward becoming of a nationally-ranked graduate research university. A longitudinal, ethnohistorical study was undertaken for the 1967-1978 period. The qualitative research methodology…

  11. Audio-Visual Space Reorganization Study. RDU-75-05.

    ERIC Educational Resources Information Center

    Baker, Martha

    Space layout and work flow patterns in the Audiovisual Center at Purdue University were studied with respect to effective space utilization and the need for planning space requirements in relationship to the activities being performed. Space and work areas were reorganized to facilitate the flow of work and materials between areas, and equipment…

  12. Rural School District Reorganization on the Great Plains.

    ERIC Educational Resources Information Center

    Bryant, Miles

    2002-01-01

    Rural school district reorganization and school consolidation are put into perspective by reviewing the large population increases that fueled small-school growth in the Great Plains, 1870-1930. Since the Dust Bowl and Great Depression, population losses, improvements in transportation, and arguments advocating economies of scale and increased…

  13. Planning for Success: Successful Implementation of Middle Level Reorganization.

    ERIC Educational Resources Information Center

    Williamson, Ronald; Johnston, J. Howard

    Drawing on the experience of public schools in Ann Arbor, Michigan, this document details a planning model and process of middle level reorganization. Following an examination of the impetus for change and how recent changes in the nation's economy, demographics, and family structure have shaped the context for educational change, collaborative…

  14. Expediting Scientific Data Analysis with Reorganization of Data

    SciTech Connect

    Byna, Surendra; Wu, Kesheng

    2013-08-19

    Data producers typically optimize the layout of data files to minimize the write time. In most cases, data analysis tasks read these files in access patterns different from the write patterns causing poor read performance. In this paper, we introduce Scientific Data Services (SDS), a framework for bridging the performance gap between writing and reading scientific data. SDS reorganizes data to match the read patterns of analysis tasks and enables transparent data reads from the reorganized data. We implemented a HDF5 Virtual Object Layer (VOL) plugin to redirect the HDF5 dataset read calls to the reorganized data. To demonstrate the effectiveness of SDS, we applied two parallel data organization techniques: a sort-based organization on a plasma physics data and a transpose-based organization on mass spectrometry imaging data. We also extended the HDF5 data access API to allow selection of data based on their values through a query interface, called SDS Query. We evaluated the execution time in accessing various subsets of data through existing HDF5 Read API and SDS Query. We showed that reading the reorganized data using SDS is up to 55X faster than reading the original data.

  15. Solvent reorganization of electron transitions in viscous solvents

    SciTech Connect

    Ghorai, Pradip K.; Matyushov, Dmitry V.

    2006-04-14

    We develop a model of electron transfer reactions at conditions of nonergodicity when the time of solvent relaxation crosses the observation time window set up by the reaction rate. Solvent reorganization energy of intramolecular electron transfer in a charge-transfer molecule dissolved in water and acetonitrile is studied by molecular dynamics simulations at varying temperatures. We observe a sharp decrease of the reorganization energy at a temperature identified as the temperature of structural arrest due to cage effect, as discussed by the mode-coupling theory. This temperature also marks the onset of the enhancement of translational diffusion relative to rotational relaxation signaling the breakdown of the Stokes-Einstein relation. The change in the reorganization energy at the transition temperature reflects the dynamical arrest of the slow, collective relaxation of the solvent related to the relaxation of the solvent dipolar polarization. An analytical theory proposed to describe this effect agrees well with both the simulations and experimental Stokes shift data. The theory is applied to the analysis of charge-transfer kinetics in a low-temperature glass former. We show that the reorganization energy is substantially lower than its equilibrium value for the low-temperature portion of the data. The theory predicts the possibility of discontinuous changes in the dependence of the electron transfer rate on the free energy gap when the reaction switches between ergodic and nonergodic regimes.

  16. 12 CFR 5.32 - Expedited procedures for certain reorganizations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., POLICIES, AND PROCEDURES FOR CORPORATE ACTIVITIES Expansion of Activities § 5.32 Expedited procedures for... company. For purposes of this section, a “bank holding company” means any company that owns or controls a national bank, or will own or control one as a result of the reorganization. (c) Licensing requirements. A...

  17. Be Vigilant on Financial Statements.

    ERIC Educational Resources Information Center

    Freed, DeBow

    2002-01-01

    Highlights areas on university's financial statements that warrant careful review by trustees and suggests ways they can check to see whether an institution's financial statements are clear and valid indicators of its financial status. (EV)

  18. Be Vigilant on Financial Statements.

    ERIC Educational Resources Information Center

    Freed, DeBow

    2002-01-01

    Highlights areas on university's financial statements that warrant careful review by trustees and suggests ways they can check to see whether an institution's financial statements are clear and valid indicators of its financial status. (EV)

  19. Youth Employment. Policy Statement.

    ERIC Educational Resources Information Center

    National Collaboration for Youth, Washington, DC.

    This paper presents the policy statement on youth employment from the National Collaboration for Youth (NCY). An introduction briefly explains the role of the NCY with regard to youth employment and describes the types of programs and services supported by NCY. A section on background provides statistics on teenagers and employment from the Bureau…

  20. Relatives' Responsibility; Policy Statement.

    ERIC Educational Resources Information Center

    American Foundation for the Blind, New York, NY.

    Presented by the American Foundation for the Blind (AFB) are background information and a policy statement on responsibility laws pertaining to relatives of applicants for public assistance. The laws are said to date to the Elizabethan Poor Laws, to vary state to state, and to mandate eligibility for public assistance on requirements of residence,…

  1. Sustainability Statement and Policy

    ERIC Educational Resources Information Center

    Journal of Education for Sustainable Development, 2009

    2009-01-01

    This article presents nine resources that focus on environmental education and sustainability. These include: (1) "Sustainability Statement and Policy," Dalhousie University, Nova Scotia, Canada, 2009, which is available at http://office.sustainability.dal.ca/Governance; (2) "Climate Literacy: The Essential Principles of Climate…

  2. Sustainability Statement and Policy

    ERIC Educational Resources Information Center

    Journal of Education for Sustainable Development, 2009

    2009-01-01

    This article presents nine resources that focus on environmental education and sustainability. These include: (1) "Sustainability Statement and Policy," Dalhousie University, Nova Scotia, Canada, 2009, which is available at http://office.sustainability.dal.ca/Governance; (2) "Climate Literacy: The Essential Principles of Climate…

  3. Environmental Impact Statements.

    ERIC Educational Resources Information Center

    Pietz, Reuel Henry

    The paper explores the role of geographers in preparing environmental impact statements (EISs). In 1969 the National Environmental Policy Act mandated that an EIS be prepared for every legislative proposal that significantly affects the environmental quality. EISs must be prepared by interdisciplinary teams representing natural and social sciences…

  4. Peer review statement

    NASA Astrophysics Data System (ADS)

    2017-09-01

    Peer review statement All papers published in this volume of Journal of Physics: Conference Series have been peer reviewed through processes administered by the proceedings Editors. Reviews were conducted by expert referees to the professional and scientific standards expected of a proceedings journal published by IOP Publishing.

  5. 76 FR 80331 - Foreign-Trade Zone 99-Wilmington, DE; Application for Reorganization and Expansion Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ... Zone 99--Wilmington, DE; Application for Reorganization and Expansion Under Alternative Site Framework... reorganize and expand the zone under the alternative site framework (ASF) adopted by the Board (74 FR 1170,...

  6. Matrix Reorganization and Dynamic Programming: Applications to Paired Comparisons and Unidimensional Seriation.

    ERIC Educational Resources Information Center

    Hubert, L. J.; Golledge, R. G.

    1981-01-01

    A recursive dynamic programing strategy for reorganizing the rows and columns of square proximity matrices is discussed. The strategy is used when the objective function measuring the adequacy of the reorganization has a fairly simple additive structure. (Author/JKS)

  7. Institutional VVM Statements on Websites

    ERIC Educational Resources Information Center

    Calder, Wm. B.

    2011-01-01

    Educational leaders rely on compelling statements of institutional beliefs, strategic direction, and purpose (i.e., values, vision, and mission statements or VVM statements) as the three major pillars by which to launch new program/service initiatives, to enhance academic and administrative operations, and to chart sustainable options in building…

  8. 3 CFR - Presidential Signing Statements

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... issued statements addressing constitutional or other legal questions upon signing bills into law (signing statements). Particularly since omnibus bills have become prevalent, signing statements have often been used... veto of the entire bill. In recent years, there has been considerable public discussion and criticism...

  9. Priorities Statements of Community Colleges.

    ERIC Educational Resources Information Center

    Illinois Community Coll. Board, Springfield.

    Each year since 1994, the 52 community colleges in Illinois prepare priority statements detailing specific college objectives for the current fiscal year (FY). This report provides the third update of the colleges' statements, covering FY 1998. Brief statements, from one to four pages, are provided for the following colleges: Belleville Area…

  10. Institutional VVM Statements on Websites

    ERIC Educational Resources Information Center

    Calder, Wm. B.

    2011-01-01

    Educational leaders rely on compelling statements of institutional beliefs, strategic direction, and purpose (i.e., values, vision, and mission statements or VVM statements) as the three major pillars by which to launch new program/service initiatives, to enhance academic and administrative operations, and to chart sustainable options in building…

  11. 29 CFR Appendix A to Part 24 - Your Rights Under the Energy Reorganization Act

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false Your Rights Under the Energy Reorganization Act A Appendix... ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Pt. 24, App. A Appendix A to Part 24—Your Rights Under the Energy Reorganization Act ER18JA11.003...

  12. 29 CFR Appendix A to Part 24 - Your Rights Under the Energy Reorganization Act

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Your Rights Under the Energy Reorganization Act A Appendix A... ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Pt. 24, App. A Appendix A to Part 24—Your Rights Under the Energy Reorganization Act ER18JA11.003...

  13. 26 CFR 54.4980B-9 - Business reorganizations and employer withdrawals from multiemployer plans.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...-9 Business reorganizations and employer withdrawals from multiemployer plans. The following... multiemployer plans: Q-1: For purposes of this section, what are a business reorganization, a stock sale, and an... 26 Internal Revenue 17 2011-04-01 2011-04-01 false Business reorganizations and...

  14. Therapy-induced brain reorganization patterns in aphasia.

    PubMed

    Abel, Stefanie; Weiller, Cornelius; Huber, Walter; Willmes, Klaus; Specht, Karsten

    2015-04-01

    Both hemispheres are engaged in recovery from word production deficits in aphasia. Lexical therapy has been shown to induce brain reorganization even in patients with chronic aphasia. However, the interplay of factors influencing reorganization patterns still remains unresolved. We were especially interested in the relation between lesion site, therapy-induced recovery, and beneficial reorganization patterns. Thus, we applied intensive lexical therapy, which was evaluated with functional magnetic resonance imaging, to 14 chronic patients with aphasic word retrieval deficits. In a group study, we aimed to illuminate brain reorganization of the naming network in comparison with healthy controls. Moreover, we intended to analyse the data with joint independent component analysis to relate lesion sites to therapy-induced brain reorganization, and to correlate resulting components with therapy gain. As a result, we found peri-lesional and contralateral activations basically overlapping with premorbid naming networks observed in healthy subjects. Reduced activation patterns for patients compared to controls before training comprised damaged left hemisphere language areas, right precentral and superior temporal gyrus, as well as left caudate and anterior cingulate cortex. There were decreasing activations of bilateral visuo-cognitive, articulatory, attention, and language areas due to therapy, with stronger decreases for patients in right middle temporal gyrus/superior temporal sulcus, bilateral precuneus as well as left anterior cingulate cortex and caudate. The joint independent component analysis revealed three components indexing lesion subtypes that were associated with patient-specific recovery patterns. Activation decreases (i) of an extended frontal lesion disconnecting language pathways occurred in left inferior frontal gyrus; (ii) of a small frontal lesion were found in bilateral inferior frontal gyrus; and (iii) of a large temporo-parietal lesion occurred in

  15. Statement of Intent

    ERIC Educational Resources Information Center

    Walter, Charmian

    2008-01-01

    The purpose of writing a charter is to show adult learners that the people providing learning for them are willing to sign up publicly to a statement of their entitlement to the very best quality of information, guidance, teaching and support--and not only to sign up to it, but to be ready to be called to account if they do not live up to the…

  16. Ligand reorganization and activation energies in nonadiabatic electron transfer reactions

    NASA Astrophysics Data System (ADS)

    Zhu, Jianjun; Wang, Jianji; Stell, George

    2006-10-01

    The activation energy and ligand reorganization energy for nonadiabatic electron transfer reactions in chemical and biological systems are investigated in this paper. The free energy surfaces and the activation energy are derived exactly in the general case in which the ligand vibration frequencies are not equal. The activation energy is derived by free energy minimization at the transition state. Our formulation leads to the Marcus-Hush [J. Chem. Phys. 24, 979 (1956); 98, 7170 (1994); 28, 962 (1958)] results in the equal-frequency limit and also generalizes the Marcus-Sumi [J. Chem. Phys. 84, 4894 (1986)] model in the context of studying the solvent dynamic effect on electron transfer reactions. It is found that when the ligand vibration frequencies are different, the activation energy derived from the Marcus-Hush formula deviates by 5%-10% from the exact value. If the reduced reorganization energy approximation is introduced in the Marcus-Hush formula, the result is almost exact.

  17. Axon substitution in the reorganization of developing neural connections.

    PubMed Central

    Bhide, P G; Frost, D O

    1992-01-01

    Insights into the mechanisms of normal and pathological neural development may be gained by studying the reorganization of developing neural connections, caused experimentally or by disease. Many reorganized connections are assumed to arise by the anomalous stabilization of transient connections that occur during normal development. We report that, although the retina projects transiently to the somatosensory system in normal developing hamsters, the permanent retinal projections to the somatosensory system that arise as a consequence of early brain lesions are not formed by the stabilization of the normally transient projection. Instead, the transient retinal axons are replaced by retinal axons that do not normally project to the somatosensory system. The distinction between anomalous stabilization and substitution is significant for determining the cellular mechanisms underlying the development of neural connectivity. Images PMID:1465409

  18. Disability, atrophy and cortical reorganization following spinal cord injury.

    PubMed

    Freund, Patrick; Weiskopf, Nikolaus; Ward, Nick S; Hutton, Chloe; Gall, Angela; Ciccarelli, Olga; Craggs, Michael; Friston, Karl; Thompson, Alan J

    2011-06-01

    The impact of traumatic spinal cord injury on structural integrity, cortical reorganization and ensuing disability is variable and may depend on a dynamic interaction between the severity of local damage and the capacity of the brain for plastic reorganization. We investigated trauma-induced anatomical changes in the spinal cord and brain, and explored their relationship to functional changes in sensorimotor cortex. Structural changes were assessed using cross-sectional cord area, voxel-based morphometry and voxel-based cortical thickness of T1-weighted images in 10 subjects with cervical spinal cord injury and 16 controls. Cortical activation in response to right-sided (i) handgrip; and (ii) median and tibial nerve stimulation were assessed using functional magnetic resonance imaging. Regression analyses explored associations between cord area, grey and white matter volume, cortical activations and thickness, and disability. Subjects with spinal cord injury had impaired upper and lower limb function bilaterally, a 30% reduced cord area, smaller white matter volume in the pyramids and left cerebellar peduncle, and smaller grey matter volume and cortical thinning in the leg area of the primary motor and sensory cortex compared with controls. Functional magnetic resonance imaging revealed increased activation in the left primary motor cortex leg area during handgrip and the left primary sensory cortex face area during median nerve stimulation in subjects with spinal cord injury compared with controls, but no increased activation following tibial nerve stimulation. A smaller cervical cord area was associated with impaired upper limb function and increased activations with handgrip and median nerve stimulation, but reduced activations with tibial nerve stimulation. Increased sensory deficits were associated with increased activations in the left primary sensory cortex face area due to median nerve stimulation. In conclusion, spinal cord injury leads to cord atrophy

  19. In Brief: Re-organization of NSF's Earth sciences

    NASA Astrophysics Data System (ADS)

    Jacobs, Judy

    2004-07-01

    The U.S. National Science Foundation announced July 16 that its Division of Earth Sciences would be re-organized into two new Sections. The Surface Earth Processes Section (SEP) will consists of the programs in hydrology (HS), education and human resources (EHR), sedimentary geology and paleobiology (SGP), geobiology and environmental geochemistry (GEG), and geomorphology and land use dynamics (GLD). The current budget for the new section is approximately $50 million per year.

  20. Multiple timescales of body schema reorganization due to plastic surgery.

    PubMed

    Iodice, Pierpaolo; Scuderi, Nicolò; Saggini, Raoul; Pezzulo, Giovanni

    2015-08-01

    Plastic surgery modifies the distribution of mass centers of a person's body segments, changing his or her posture. The functional reorganization processes that lead subjects to re-integrate these body changes into a new stable body (posture) schema is poorly understood but current theories suggest the possible contribution of two components: a feedback mechanism that strongly depends on sensory input and an internal model that is relatively less dependent on sensory input and improves posture control, for example by compensating for delayed feedback. To assess the relative contributions of these two mechanisms during the functional reorganization of a posture scheme, we have conducted a longitudinal postural study in a population of healthy adults who were subject to breast plastic surgery to reduce or augment body weight. We measured participants' orthostatic posture and ground reaction force immediately after, after 4 months, and 1 year after the surgery. To investigate the role of visual sensory information in the reorganization process we tested the participants with eyes open and closed. Our results indicate that participants find a new dynamical equilibrium within a few days. However, posture maintenance remains sub-optimal long after the center of masses and the resultant of ground reaction force stop changing; in some cases, for more than 4 months. Furthermore, the re-adaptation process is faster and more efficient in the eyes-open than in the eyes-closed condition. These results suggest that the reorganization involves different subsystems (responsible for the biomechanical changes, the re-calibration of feedback mechanisms, and the re-adaptation of internal models), which act at different timescales. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. U.S. climate variability and predictability program reorganizes

    NASA Astrophysics Data System (ADS)

    Legler, David M.

    2005-07-01

    Scientific advances, new ways of organizing research, and changes in the programmatic and budget landscapes have motivated an evaluation and reorganization of the U.S. Climate Variability and Predictability (U.S. CLIVAR) program (CLIVAR is part of the World Climate Research Programme (WCRP)). After considering a number of inputs and to ensure that U.S. CLIVAR is well structured to meet relevant objectives over the next decade, the program is changing its scientific committee infrastructure.

  2. Discrete Model for Inner-Sphere Reorganization of Anions.

    DTIC Science & Technology

    1986-05-01

    approaches can be followed to calculate the energy of inner-sphere reorganization in photoionization. (i) The terms not corresponding to nuclear ...motion and the outer-sphere Born solvation term are subtracted from the experimental solvation energy . (ii) Only the terms pertaining to nuclear motion...aq), respectively. The term U f(nucl) in eq. (1) represents the nuclear contribution to the solvation energy of the species A(aq) surrounded by its

  3. A reorganization cyberinfrastructure of history observing data in China

    NASA Astrophysics Data System (ADS)

    Lin, Ganghua; Ji, Haisheng; Lin, Jun; Tan, Chengmin; Du, Zhangle; Ding, Minde; Liu, Suo; Zhao, Cui; Yang, Xiao; Wang, Xiaofan; Deng, Yuanyong

    2016-08-01

    Astronomical data analysis depends on the accumulation of data, including integrity of data in observing location, time, and diversity of data. We are now developing a reorganization project of solar physics history data of China. There are 90 years, 44 kinds of solar observing data in China. In the project, we will finish imagination, digitalization and standardization of these data. This article introduces the project framework, data, data processing, and how to share.

  4. A molecularly based theory for electron transfer reorganization energy.

    PubMed

    Zhuang, Bilin; Wang, Zhen-Gang

    2015-12-14

    Using field-theoretic techniques, we develop a molecularly based dipolar self-consistent-field theory (DSCFT) for charge solvation in pure solvents under equilibrium and nonequilibrium conditions and apply it to the reorganization energy of electron transfer reactions. The DSCFT uses a set of molecular parameters, such as the solvent molecule's permanent dipole moment and polarizability, thus avoiding approximations that are inherent in treating the solvent as a linear dielectric medium. A simple, analytical expression for the free energy is obtained in terms of the equilibrium and nonequilibrium electrostatic potential profiles and electric susceptibilities, which are obtained by solving a set of self-consistent equations. With no adjustable parameters, the DSCFT predicts activation energies and reorganization energies in good agreement with previous experiments and calculations for the electron transfer between metallic ions. Because the DSCFT is able to describe the properties of the solvent in the immediate vicinity of the charges, it is unnecessary to distinguish between the inner-sphere and outer-sphere solvent molecules in the calculation of the reorganization energy as in previous work. Furthermore, examining the nonequilibrium free energy surfaces of electron transfer, we find that the nonequilibrium free energy is well approximated by a double parabola for self-exchange reactions, but the curvature of the nonequilibrium free energy surface depends on the charges of the electron-transferring species, contrary to the prediction by the linear dielectric theory.

  5. Forelimb training drives transient map reorganization in ipsilateral motor cortex.

    PubMed

    Pruitt, David T; Schmid, Ariel N; Danaphongse, Tanya T; Flanagan, Kate E; Morrison, Robert A; Kilgard, Michael P; Rennaker, Robert L; Hays, Seth A

    2016-10-15

    Skilled motor training results in reorganization of contralateral motor cortex movement representations. The ipsilateral motor cortex is believed to play a role in skilled motor control, but little is known about how training influences reorganization of ipsilateral motor representations of the trained limb. To determine whether training results in reorganization of ipsilateral motor cortex maps, rats were trained to perform the isometric pull task, an automated motor task that requires skilled forelimb use. After either 3 or 6 months of training, intracortical microstimulation (ICMS) mapping was performed to document motor representations of the trained forelimb in the hemisphere ipsilateral to that limb. Motor training for 3 months resulted in a robust expansion of right forelimb representation in the right motor cortex, demonstrating that skilled motor training drives map plasticity ipsilateral to the trained limb. After 6 months of training, the right forelimb representation in the right motor cortex was significantly smaller than the representation observed in rats trained for 3 months and similar to untrained controls, consistent with a normalization of motor cortex maps. Forelimb map area was not correlated with performance on the trained task, suggesting that task performance is maintained despite normalization of cortical maps. This study provides new insights into how the ipsilateral cortex changes in response to skilled learning and may inform rehabilitative strategies to enhance cortical plasticity to support recovery after brain injury.

  6. Dispersal governs the reorganization of ecological networks under environmental change.

    PubMed

    Thompson, Patrick L; Gonzalez, Andrew

    2017-05-08

    Ecological networks, such as food webs, mutualist webs and host-parasite webs, are reorganizing as species abundances and spatial distributions shift in response to environmental change. Current theoretical expectations for how this reorganization will occur are available for competition or for parts of interaction networks, but these may not extend to more complex networks. Here we use metacommunity theory to develop new expectations for how complex networks will reorganize under environmental change, and show that dispersal is crucial for determining the degree to which networks will retain their composition and structure. When dispersal between habitat patches is low, all types of species interactions act as a strong determinant for whether species can colonize suitable habitats. This colonization resistance drives species turnover, which breaks apart current networks and leads to the formation of new networks. However, when dispersal rates are increased, colonists arrive in high abundance in habitats where they are well adapted, so interactions with resident species contribute less to colonization success. Dispersal ensures that species associations are maintained as they shift in space, so networks retain similar composition and structure. The crucial role of dispersal reinforces the need to manage habitat connectivity to sustain species and interaction diversity into the future.

  7. A molecularly based theory for electron transfer reorganization energy

    SciTech Connect

    Zhuang, Bilin; Wang, Zhen-Gang

    2015-12-14

    Using field-theoretic techniques, we develop a molecularly based dipolar self-consistent-field theory (DSCFT) for charge solvation in pure solvents under equilibrium and nonequilibrium conditions and apply it to the reorganization energy of electron transfer reactions. The DSCFT uses a set of molecular parameters, such as the solvent molecule’s permanent dipole moment and polarizability, thus avoiding approximations that are inherent in treating the solvent as a linear dielectric medium. A simple, analytical expression for the free energy is obtained in terms of the equilibrium and nonequilibrium electrostatic potential profiles and electric susceptibilities, which are obtained by solving a set of self-consistent equations. With no adjustable parameters, the DSCFT predicts activation energies and reorganization energies in good agreement with previous experiments and calculations for the electron transfer between metallic ions. Because the DSCFT is able to describe the properties of the solvent in the immediate vicinity of the charges, it is unnecessary to distinguish between the inner-sphere and outer-sphere solvent molecules in the calculation of the reorganization energy as in previous work. Furthermore, examining the nonequilibrium free energy surfaces of electron transfer, we find that the nonequilibrium free energy is well approximated by a double parabola for self-exchange reactions, but the curvature of the nonequilibrium free energy surface depends on the charges of the electron-transferring species, contrary to the prediction by the linear dielectric theory.

  8. Treatment provider's knowledge of the Health and Disability Commissioner's Code of Consumer Rights.

    PubMed

    Townshend, Philip L; Sellman, J Douglas

    2002-06-01

    The Health and Disability Commissioner's (HDC) Code of Health and and Disability Consumers' Rights (the Code) defines in law the rights of consumers of health and disability services in New Zealand. In the first few years after the publication health educators, service providers and the HDC extensively promoted the Code. Providers of health and disability services would be expected to be knowledgeable about the areas covered by the Code if it is routinely used in the development and monitoring of treatment plans. In this study knowledge of the Code was tested in a random sample of 217 clinical staff that included medical staff, psychologists and counsellors working in Alcohol and Drug Treatment (A&D) centres in New Zealand. Any response showing awareness of a right, regardless of wording, was taken as a positive response as it was the areas covered by rights rather than their actual wording that was considered to be the important knowledge for providers. The main finding of this research was that 23% of staff surveyed were aware of none of the ten rights in the Code and only 6% were aware of more than five of the ten rights. Relating these data to results from a wider sample of treatment providers raises the possibility that A&D treatment providers are slightly more aware of the content of the Code than a general sample of health and disability service providers however overall awareness of the content of the Code by health providers is very low. These results imply that consumer rights issues are not prominent in the minds of providers perhaps indicating an ethical blind spot on their part. Ignorance of the content of the Code may indicate that the treatment community do not find it a useful working document or alternatively that clinicians are content to rely on their own good intentions to preserve the rights of their patients. Further research will be required to explain this lack of knowledge, however the current situation is that consumers cannot rely on

  9. Adherence to exercise referral schemes by participants - what do providers and commissioners need to know? A systematic review of barriers and facilitators.

    PubMed

    Morgan, Fiona; Battersby, Alysia; Weightman, Alison L; Searchfield, Lydia; Turley, Ruth; Morgan, Helen; Jagroo, James; Ellis, Simon

    2016-03-05

    Physical inactivity levels are rising worldwide with major implications for the health of the population and the prevalence of non-communicable diseases. Exercise referral schemes (ERS) continue to be a popular intervention utilised by healthcare practitioners to increase physical activity. We undertook a systematic review of views studies in order to inform guidance from the UK National Institute of Health and Care Excellence (NICE) on exercise referral schemes to promote physical activity. This paper reports on the participant views identified, to inform those seeking to refine schemes to increase attendance and adherence. Fifteen databases and a wide range of websites and grey literature sources were searched systematically for publications from 1995 to June 2013. In addition, a range of supplementary methods including, a call for evidence by NICE, contacting authors, reference list checking and citation tracking were utilised to identify additional research. Studies were included where they detailed schemes for adults aged 19 years or older who were 'inactive' (i.e. they are not currently meeting UK physical activity guidelines). Study selection was conducted independently in duplicate. Quality assessment was undertaken by one reviewer and checked by a second, with 20 % of papers being considered independently in duplicate. Papers were coded in qualitative data analysis software Atlas.ti. This review was reported in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement). Evidence from 33 UK-relevant studies identified that support from providers, other attendees and family was an important facilitator of adherence and 'making exercise a habit' post programme, as was the variety and personalised nature of sessions offered. Barriers to attendance included the inconvenient timing of sessions, their cost and location. An intimidating gym atmosphere, a dislike of the music and TV and a lack of confidence in operating

  10. Position statement on cannabis.

    PubMed

    Stein For The Executive Committee Of The Central Drug Authority, Dan Joseph

    2016-05-16

    There is an ongoing national debate around cannabis policy. This brief position statement by the Executive Committee of the Central Drug Authorityoutlines some of the factors that have contributed to this debate, delineates reduction strategies, summarises the harms and benefits ofmarijuana, and provides recommendations. These recommendations emphasise an integrated and evidence-based approach, the need forresources to implement harm reduction strategies against continued and chronic use of alcohol and cannabis, and the potential value of afocus on decriminalisation rather than the legalisation of cannabis.

  11. 7 CFR 3052.310 - Financial statements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Financial statements. 3052.310 Section 3052.310....310 Financial statements. (a) Financial statements. The auditee shall prepare financial statements... appropriate, cash flows for the fiscal year audited. The financial statements shall be for the same...

  12. 29 CFR 99.310 - Financial statements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 1 2013-07-01 2013-07-01 false Financial statements. 99.310 Section 99.310 Labor Office of....310 Financial statements. (a) Financial statements. The auditee shall prepare financial statements... appropriate, cash flows for the fiscal year audited. The financial statements shall be for the same...

  13. 7 CFR 3052.310 - Financial statements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Financial statements. 3052.310 Section 3052.310....310 Financial statements. (a) Financial statements. The auditee shall prepare financial statements... appropriate, cash flows for the fiscal year audited. The financial statements shall be for the same...

  14. 7 CFR 3052.310 - Financial statements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Financial statements. 3052.310 Section 3052.310....310 Financial statements. (a) Financial statements. The auditee shall prepare financial statements... appropriate, cash flows for the fiscal year audited. The financial statements shall be for the same...

  15. Pediatrician workforce policy statement.

    PubMed

    Basco, William T; Rimsza, Mary E

    2013-08-01

    This policy statement reviews important trends and other factors that affect the pediatrician workforce and the provision of pediatric health care, including changes in the pediatric patient population, pediatrician workforce, and nature of pediatric practice. The effect of these changes on pediatricians and the demand for pediatric care are discussed. The American Academy of Pediatrics (AAP) concludes that there is currently a shortage of pediatric medical subspecialists in many fields, as well as a shortage of pediatric surgical specialists. In addition, the AAP believes that the current distribution of primary care pediatricians is inadequate to meet the needs of children living in rural and other underserved areas, and more primary care pediatricians will be needed in the future because of the increasing number of children who have significant chronic health problems, changes in physician work hours, and implementation of current health reform efforts that seek to improve access to comprehensive patient- and family-centered care for all children in a medical home. The AAP is committed to being an active participant in physician workforce policy development with both professional organizations and governmental bodies to ensure a pediatric perspective on health care workforce issues. The overall purpose of this statement is to summarize policy recommendations and serve as a resource for the AAP and other stakeholders as they address pediatrician workforce issues that ultimately influence the quality of pediatric health care provided to children in the United States.

  16. Epiplakin attenuates experimental mouse liver injury by chaperoning keratin reorganization

    PubMed Central

    Szabo, Sandra; Wögenstein, Karl L.; Österreicher, Christoph H.; Guldiken, Nurdan; Chen, Yu; Doler, Carina; Wiche, Gerhard; Boor, Peter; Haybaeck, Johannes; Strnad, Pavel; Fuchs, Peter

    2015-01-01

    Background & Aims Epiplakin is a member of the plakin protein family and exclusively expressed in epithelial tissues where it binds to keratins. Epiplakin-deficient (Eppk1−/−) mice displayed no obvious spontaneous phenotype, but their keratinocytes showed a faster keratin network breakdown in response to stress. The role of epiplakin in the stressed liver remained to be elucidated. Methods Wild-type (WT) and Eppk1−/− mice were subjected to common bile duct ligation (CBDL) or fed with a 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-containing diet. The importance of epiplakin during keratin reorganization was assessed in primary hepatocytes. Results Our experiments revealed that epiplakin is expressed in hepatocytes and cholangiocytes, and binds to keratin 8 (K8) and K18 via multiple domains. In several liver stress models epiplakin and K8 genes displayed identical expression patterns and transgenic K8 overexpression resulted in elevated hepatic epiplakin levels. After CBDL and DDC treatment, Eppk1−/− mice developed a more pronounced liver injury and their livers contained larger amounts of hepatocellular keratin granules, indicating impaired disease-induced keratin network reorganization. In line with these findings, primary Eppk1−/− hepatocytes showed increased formation of keratin aggregates after treatment with the phosphatase inhibitor okadaic acid, a phenotype which was rescued by the chemical chaperone trimethylamine N-oxide (TMAO). Finally, transfection experiments revealed that Eppk1−/− primary hepatocytes were less able to tolerate forced K8 overexpression and that TMAO treatment rescued this phenotype. Conclusion Our data indicate that epiplakin plays a protective role during experimental liver injuries by chaperoning disease-induced keratin reorganization. PMID:25617501

  17. Cortical reorganization in patients with cervical spondylotic myelopathy

    PubMed Central

    Holly, Langston T.; Dong, Yun; Albistegui-DuBois, Richard; Marehbian, Jonathan; Dobkin, Bruce

    2014-01-01

    Object Recent investigations have demonstrated that the cerebral cortex can reorganize as a result of spinal cord injury and may play a role in preserving neurological function. Reorganization of cortical representational maps in patients with cervical spondylotic myelopathy (CSM) has not been previously described. The authors sought to determine the feasibility of using functional magnetic resonance (fMR) imaging in patients with CSM to investigate changes in the cortical representation of the wrist and ankle before and after surgical intervention. Methods Four patients with clinical and imaging evidence of CSM were prospectively enrolled in this study. The patients underwent preoperative neurological examination, functional assessment, cervical imaging, and brain fMR imaging. The fMR imaging activation task undertaken was either wrist extension or ankle dorsiflexion, depending on whether the patient's primary impairment was hand dysfunction or gait difficulty. The cohort then underwent further evaluations at 6 weeks and 3 and 6 months postoperatively. In addition, five healthy volunteers underwent fMR imaging at two different time points and served as controls. In the healthy volunteers fMR imaging demonstrated areas of focal cortical activation limited to the contralateral primary motor area for the assigned motor tasks; the activation patterns were stable throughout repeated imaging. In comparison, in patients with CSM fMR imaging demonstrated expansion of the cortical representation of the affected extremity. Surgical decompression resulted in improvements in neurological function and reorganization of the representational map. Conclusions The findings of this preliminary study demonstrate the potential of fMR imaging to assess changes in cortical representation before and after surgical intervention in patients with CSM. A future study involving a larger cohort of patients as well as the stratification of patients with CSM, based on the aforementioned factors

  18. Episodic tectonic plate reorganizations driven by mantle convection

    NASA Astrophysics Data System (ADS)

    King, Scott D.; Lowman, Julian P.; Gable, Carl W.

    2002-10-01

    Periods of relatively uniform plate motion were interrupted several times throughout the Cenozoic and Mesozoic by rapid plate reorganization events [R. Hey, Geol. Soc. Am. Bull. 88 (1977) 1404-1420; P.A. Rona, E.S. Richardson, Earth Planet. Sci. Lett. 40 (1978) 1-11; D.C. Engebretson, A. Cox, R.G. Gordon, Geol. Soc. Am. Spec. Pap. 206 (1985); R.G. Gordon, D.M. Jurdy, J. Geophys. Res. 91 (1986) 12389-12406; D.A. Clague, G.B. Dalrymple, US Geol. Surv. Prof. Pap. 1350 (1987) 5-54; J.M. Stock, P. Molnar, Nature 325 (1987) 495-499; C. Lithgow-Bertelloni, M.A. Richards, Geophys. Res. Lett. 22 (1995) 1317-1320; M.A. Richards, C. Lithgow-Bertelloni, Earth Planet. Sci. Lett. 137 (1996) 19-27; C. Lithgow-Bertelloni, M.A. Richards, Rev. Geophys. 36 (1998) 27-78]. It has been proposed that changes in plate boundary forces are responsible for these events [M.A. Richards, C. Lithgow-Bertelloni, Earth Planet. Sci. Lett. 137 (1996) 19-27; C. Lithgow-Bertelloni, M.A. Richards, Rev. Geophys. 36 (1998) 27-78]. We present an alternative hypothesis: convection-driven plate motions are intrinsically unstable due to a buoyant instability that develops as a result of the influence of plates on an internally heated mantle. This instability, which has not been described before, is responsible for episodic reorganizations of plate motion. Numerical mantle convection experiments demonstrate that high-Rayleigh number convection with internal heating and surface plates is sufficient to induce plate reorganization events, changes in plate boundary forces, or plate geometry, are not required.

  19. Functional reorganization of sensorimotor cortex in early Parkinson disease

    PubMed Central

    Kojovic, M.; Bologna, M.; Kassavetis, P.; Murase, N.; Palomar, F.J.; Berardelli, A.; Rothwell, J.C.; Edwards, M.J.

    2012-01-01

    Objective: Compensatory reorganization of the nigrostriatal system is thought to delay the onset of symptoms in early Parkinson disease (PD). Here we sought evidence that compensation may be a part of a more widespread functional reorganization in sensorimotor networks, including primary motor cortex. Methods: Several neurophysiologic measures known to be abnormal in the motor cortex (M1) of patients with advanced PD were tested on the more and less affected side of 16 newly diagnosed and drug-naive patients with PD and compared with 16 age-matched healthy participants. LTP-like effects were probed using a paired associative stimulation protocol. We also measured short interval intracortical inhibition, intracortical facilitation, cortical silent period, and input/output curves. Results: The less affected side in patients with PD had preserved intracortical inhibition and a larger response to the plasticity protocol compared to healthy participants. On the more affected side, there was no response to the plasticity protocol and inhibition was reduced. There was no difference in input/output curves between sides or between patients with PD and healthy participants. Conclusions: Increased motor cortical plasticity on the less affected side is consistent with a functional reorganization of sensorimotor cortex and may represent a compensatory change that contributes to delaying onset of clinical symptoms. Alternatively, it may reflect a maladaptive plasticity that provokes symptom onset. Plasticity deteriorates as the symptoms progress, as seen on the more affected side. The rate of change in paired associative stimulation response over time could be developed into a surrogate marker of disease progression in PD. PMID:22517098

  20. Plasma membrane reorganization induced by chemical transformation in cultura

    SciTech Connect

    Packard, B.S.

    1984-04-01

    Induction of increased rigidity in the plasma membrane paralleling properties associated with a transformed state was suggested by two experiments. Fluorescence recovery after photobleaching (FRAP) indicated the induction of an environment in the plasma membrane where the synthetic fluorescent phospholipid collarein was immobile on the FRAP timescale. The other technique revealed the binding of epidermal growth factor (EGF) to a cryptic class of receptors which become accessible upon chemical transformation. These two lines of evidence are consistent with a reorganization of the plasma membrane induced by tumor promoters. 110 references, 38 figures, 4 tables.

  1. Cortical reorganization in multiple sclerosis after intrathecal baclofen therapy.

    PubMed

    Guerrera, S; Morabito, R; Baglieri, A; Corallo, F; Ciurleo, R; De Luca, R; De Salvo, S; Marino, M A; Spadaro, L; Timpano, F; Bramanti, P; Marino, S

    2014-04-01

    Our objective was to assess the role of Intrathecal Baclofen Therapy (ITB) in the cortical reorganization in a patient affected by multiple sclerosis (MS) undergoing physical therapy. We reported a case of a woman affected by MS and severe spasticity, who performed an fMRI examination, before and after the ITB implantation. The subject showed controlateral motor cortex activation after motor task. After a month of ITB implantation, patient showed ipsilateral and controlateral motor cortex activation although with a broader extension. fMRI examination supported the hypothesis of a central influence in patients who undergo physiotherapy and therapy with ITB.

  2. [Restructuring and reorganization project in the public health area].

    PubMed

    Crosetto, M A; Caballero, G

    1999-01-01

    The objective of this project is to produce substantial change as regards the reorganization, reconstruction and normalization of the hospital data to extra hospital data recording system from the Ministry of Health in the Province of Córdoba (Argentina). In order to incorporate socio-demographic factors in the various data forms so asa to produce efficiency upon the politic implemented. To achieve such aim, colwork on the different levels of execution, training the health team with respect to the identification of the population problems, and attempting to change of a demographic basis the current sanitary policies into policies of populations.

  3. Global Dynamic Numerical Simulations of Plate Tectonic Reorganizations

    NASA Astrophysics Data System (ADS)

    Morra, G.; Quevedo, L.; Butterworth, N.; Matthews, K. J.; Müller, D.

    2010-12-01

    We use a new numerical approach for global geodynamics to investigate the origin of present global plate motion and to identify the causes of the last two global tectonic reorganizations occurred about 50 and 100 million years ago (Ma) [1]. While the 50 Ma event is the most well-known global plate-mantle event, expressed by the bend in the Hawaiian-Emperor volcanic chain, a prominent plate reorganization at about 100 Ma, although presently little studied, is clearly indicated by a major bend in the fracture zones in the Indian Ocean and by a change in Pacific plate motion [2]. Our workflow involves turning plate reconstructions into surface meshes that are subsequently employed as initial conditions for global Boundary Element numerical models. The tectonic setting that anticipates the reorganizations is processed with the software GPlates, combining the 3D mesh of the paleo-plate morphology and the reconstruction of paleo-subducted slabs, elaborated from tectonic history [3]. All our models involve the entire planetary system, are fully dynamic, have free surface, are characterized by a spectacular computational speed due to the simultaneous use of the multi-pole algorithm and the Boundary Element formulation and are limited only by the use of sharp material property variations [4]. We employ this new tool to unravel the causes of plate tectonic reorganizations, producing and comparing global plate motion with the reconstructed ones. References: [1] Torsvik, T., Müller, R.D., Van der Voo, R., Steinberger, B., and Gaina, C., 2008, Global Plate Motion Frames: Toward a unified model: Reviews in Geophysics, VOL. 46, RG3004, 44 PP., 2008 [2] Wessel, P. and Kroenke, L.W. Pacific absolute plate motion since 145 Ma: An assessment of the fixed hot spot hypothesis. Journal of Geophysical Research, Vol 113, B06101, 2008 [3] L. Quevedo, G. Morra, R. D. Mueller. Parallel Fast Multipole Boundary Element Method for Crustal Dynamics, Proceeding 9th World Congress and 4th Asian

  4. Commentary on Causal Prescriptive Statements

    ERIC Educational Resources Information Center

    Graesser, Arthur C.; Hu, Xiangen

    2011-01-01

    Causal prescriptive statements are valued in the social sciences when there is the goal of helping people through interventions. The articles in this special issue cover different methods for testing causal prescriptive statements. This commentary identifies both virtues and liabilities of these different approaches. We argue that it is extremely…

  5. Aerospace Education. NSTA Position Statement

    ERIC Educational Resources Information Center

    National Science Teachers Association (NJ1), 2008

    2008-01-01

    National Science Teachers Association (NSTA) has developed a new position statement, "Aerospace Education." NSTA believes that aerospace education is an important component of comprehensive preK-12 science education programs. This statement highlights key considerations that should be addressed when implementing a high quality aerospace education…

  6. Priorities Statements of Community Colleges.

    ERIC Educational Resources Information Center

    Illinois Community Coll. Board, Springfield.

    In response to recommendations in the Illinois Board of Higher Education's Priorities, Quality, and Productivity report of November 1994, the 52 community colleges in the state prepared priority statements detailing specific college objectives for the current fiscal year (FY). This report provides the second update of the colleges' statements,…

  7. Commentary on Causal Prescriptive Statements

    ERIC Educational Resources Information Center

    Graesser, Arthur C.; Hu, Xiangen

    2011-01-01

    Causal prescriptive statements are valued in the social sciences when there is the goal of helping people through interventions. The articles in this special issue cover different methods for testing causal prescriptive statements. This commentary identifies both virtues and liabilities of these different approaches. We argue that it is extremely…

  8. Reading and understanding financial statements.

    PubMed

    White, Joseph P

    2005-01-01

    Feeling comfortable reading and understanding financial statements is critical to the success of healthcare executives and physicians involved in management. Businesses use three primary financial statements: a balance sheet represents the equation, Assets = Liabilities + Equity; an income statement represents the equation, Revenues - Expenses = Net Income; a statement of cash flows reports all sources and uses of cash during the represented period. The balance sheet expresses financial indicators at one particular moment in time, whereas the income statement and the statement of cash flows show activity that occurred over a stretch of time. Additional information is disclosed in attached footnotes and other supplementary materials. There are two ways to prepare financial statements. Cash-basis accounting recognizes revenue when it is received and expenses when they are paid. Accrual-basis accounting recognizes revenue when it is earned and expenses when they are incurred. Although cash-basis is acceptable, periodically using the accrual method reveals important information about receivables and liabilities that could otherwise remain hidden. Become more engaged with your financial statements by spending time reading them, tracking key performance indicators, and asking accountants and financial advisors questions. This will help you better understand your business and build a successful future.

  9. Mission statements in Canadian hospitals.

    PubMed

    Bart, Christopher K; Hupfer, Maureen

    2004-01-01

    One of the most popular management tools in the world, the mission statement also is subject to widespread criticism. In order to improve our understanding of the mission statement's strategic value and to provide actionable recommendations for healthcare organizations, the paper adopted a social constructionist perspective in a mission statement study conducted among Canadian hospital executives. The paper found seven factors underlying 23 possible mission statement content items. Four of these (grand inspiration, benefactors, competitive orientation and business definition) corresponded to the dimensions of dominant managerial logic proposed by von Krogh and Grand, and were positively related to various behavioral, financial performance and mission achievement measures. The findings indicate that not all mission statement components are created equal and that the recommendations of major strategy texts may require reconsideration where this particular institutional context is concerned.

  10. Statement on virginity testing.

    PubMed

    2015-07-01

    Virginity testing (virginity examination) is a gynecological examination that is intended to correlate the status and appearance of the hymen with previous sexual contact to determine whether a female has had or is habituated to sexual intercourse. Virginity examinations are practiced in many countries, often forcibly, including in detention places; on women who allege rape or are accused of prostitution; and as part of public or social policies to control sexuality. The Independent Forensic Expert Group (IFEG) - thirty-five preeminent independent forensic experts from eighteen countries specialized in evaluating and documenting the physical and psychological effects of torture and ill-treatment - released a statement on the practice in December 2014. In its statement, the IFEG outlines the physical and psychological effects of forcibly conducting virginity examinations on females based on its collective experience. The Group assesses whether, based on the effects, forcibly conducted virginity examinations constitute cruel, inhuman, or degrading treatment or torture. Finally, the IFEG addresses the medical interpretation, relevance, and ethical implications of such examinations. The IFEG concludes that virginity examinations are medically unreliable and have no clinical or scientific value. These examinations are inherently discriminatory and, in almost all instances, when conducted forcibly, result in significant physical and mental pain and suffering, thereby constituting cruel, inhuman and degrading treatment or torture. When virginity examinations are forcibly conducted and involve vaginal penetration, the examination should be considered as sexual assault and rape. Involvement of health professionals in these examinations violates the basic standards and ethics of the professions. Copyright © 2015 Torture. Published by Elsevier Ltd.. All rights reserved.

  11. From network structure to network reorganization: implications for adult neurogenesis

    NASA Astrophysics Data System (ADS)

    Schneider-Mizell, Casey M.; Parent, Jack M.; Ben-Jacob, Eshel; Zochowski, Michal R.; Sander, Leonard M.

    2010-12-01

    Networks can be dynamical systems that undergo functional and structural reorganization. One example of such a process is adult hippocampal neurogenesis, in which new cells are continuously born and incorporate into the existing network of the dentate gyrus region of the hippocampus. Many of these introduced cells mature and become indistinguishable from established neurons, joining the existing network. Activity in the network environment is known to promote birth, survival and incorporation of new cells. However, after epileptogenic injury, changes to the connectivity structure around the neurogenic niche are known to correlate with aberrant neurogenesis. The possible role of network-level changes in the development of epilepsy is not well understood. In this paper, we use a computational model to investigate how the structural and functional outcomes of network reorganization, driven by addition of new cells during neurogenesis, depend on the original network structure. We find that there is a stable network topology that allows the network to incorporate new neurons in a manner that enhances activity of the persistently active region, but maintains global network properties. In networks having other connectivity structures, new cells can greatly alter the distribution of firing activity and destroy the initial activity patterns. We thus find that new cells are able to provide focused enhancement of network only for small-world networks with sufficient inhibition. Network-level deviations from this topology, such as those caused by epileptogenic injury, can set the network down a path that develops toward pathological dynamics and aberrant structural integration of new cells.

  12. Cooperative hand movements in post-stroke subjects: Neural reorganization.

    PubMed

    Schrafl-Altermatt, Miriam; Dietz, Volker

    2016-01-01

    Recent research indicates a task-specific neural coupling controlling cooperative hand movements reflected in bilateral electromyographic reflex responses in arm muscles following unilateral nerve stimulation. Reorganization of this mechanism was explored in post-stroke patients in this study. Electromyographic reflex responses in forearm muscles to unilateral electrical ulnar nerve stimulation were examined during cooperative and non-cooperative hand movements. Stimulation of the unaffected arm during cooperative hand movements led to electromyographic responses in bilateral forearm muscles, similar to those seen in healthy subjects, while stimulation of the affected side was followed only by ipsilateral responses. No contralateral reflex responses could be evoked in severely affected patients. The presence of contralateral responses correlated with the clinical motor impairment as assessed by the Fugl-Meyer test. The observations suggest that after stroke an impaired processing of afferent input from the affected side leads to a defective neural coupling and is associated with a greater involvement of fiber tracts from the unaffected hemisphere during cooperative hand movements. The mechanism of neural coupling underlying cooperative hand movements is shown to be defective in post-stroke patients. The neural re-organizations observed have consequences for the rehabilitation of hand function. Copyright © 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

  13. Retinotopically specific reorganization of visual cortex for tactile pattern recognition

    PubMed Central

    Cheung, Sing-Hang; Fang, Fang; He, Sheng; Legge, Gordon E.

    2009-01-01

    Although previous studies have shown that Braille reading and other tactile-discrimination tasks activate the visual cortex of blind and sighted people [1–5], it is not known whether this kind of cross-modal reorganization is influenced by retinotopic organization. We have addressed this question by studying S, a visually impaired adult with the rare ability to read print visually and Braille by touch. S had normal visual development until age six years, and thereafter severe acuity reduction due to corneal opacification, but no evidence of visual-field loss. Functional magnetic resonance imaging (fMRI) revealed that, in S’s early visual areas, tactile information processing activated what would be the foveal representation for normally-sighted individuals, and visual information processing activated what would be the peripheral representation. Control experiments showed that this activation pattern was not due to visual imagery. S’s high-level visual areas which correspond to shape- and object-selective areas in normally-sighted individuals were activated by both visual and tactile stimuli. The retinotopically specific reorganization in early visual areas suggests an efficient redistribution of neural resources in the visual cortex. PMID:19361999

  14. Self-repairing symmetry in jellyfish through mechanically driven reorganization

    PubMed Central

    Abrams, Michael J.; Basinger, Ty; Yuan, William; Guo, Chin-Lin; Goentoro, Lea

    2015-01-01

    What happens when an animal is injured and loses important structures? Some animals simply heal the wound, whereas others are able to regenerate lost parts. In this study, we report a previously unidentified strategy of self-repair, where moon jellyfish respond to injuries by reorganizing existing parts, and rebuilding essential body symmetry, without regenerating what is lost. Specifically, in response to arm amputation, the young jellyfish of Aurelia aurita rearrange their remaining arms, recenter their manubria, and rebuild their muscular networks, all completed within 12 hours to 4 days. We call this process symmetrization. We find that symmetrization is not driven by external cues, cell proliferation, cell death, and proceeded even when foreign arms were grafted on. Instead, we find that forces generated by the muscular network are essential. Inhibiting pulsation using muscle relaxants completely, and reversibly, blocked symmetrization. Furthermore, we observed that decreasing pulse frequency using muscle relaxants slowed symmetrization, whereas increasing pulse frequency by lowering the magnesium concentration in seawater accelerated symmetrization. A mathematical model that describes the compressive forces from the muscle contraction, within the context of the elastic response from the mesoglea and the ephyra geometry, can recapitulate the recovery of global symmetry. Thus, self-repair in Aurelia proceeds through the reorganization of existing parts, and is driven by forces generated by its own propulsion machinery. We find evidence for symmetrization across species of jellyfish (Chrysaora pacifica, Mastigias sp., and Cotylorhiza tuberculata). PMID:26080418

  15. Dynamic reorganization of photosynthetic supercomplexes during environmental acclimation of photosynthesis

    PubMed Central

    Minagawa, Jun

    2013-01-01

    Plants and algae have acquired the ability to acclimate to ever-changing environments in order to survive. During photosynthesis, light energy is converted by several membrane protein supercomplexes into electrochemical energy, which is eventually used to assimilate CO2. The efficiency of photosynthesis is modulated by many environmental factors such as quality and quantity of light, temperature, drought, and CO2 concentration, among others. Accumulating evidence indicates that photosynthetic supercomplexes undergo supramolecular reorganization within a short time frame during acclimation to an environmental change. This reorganization includes state transitions that balance the excitation of photosystem I and II by shuttling peripheral antenna proteins between the two, thermal energy dissipation that occurs at energy-quenching sites within the light-harvesting antenna generated for negative feedback when excess light is absorbed, and cyclic electron flow that is facilitated between photosystem I and the cytochrome bf complex when cells demand more ATP and/or need to activate energy dissipation. This review will highlight the recent findings regarding these environmental acclimation events in model organisms with particular attention to the unicellular green alga C. reinhardtii and with reference to the vascular plant A. thaliana, which offers a glimpse into the dynamic behavior of photosynthetic machineries in nature. PMID:24381578

  16. Dynamic reorganization of brain functional networks during cognition.

    PubMed

    Bola, Michał; Sabel, Bernhard A

    2015-07-01

    How does cognition emerge from neural dynamics? The dominant hypothesis states that interactions among distributed brain regions through phase synchronization give basis for cognitive processing. Such phase-synchronized networks are transient and dynamic, established on the timescale of milliseconds in order to perform specific cognitive operations. But unlike resting-state networks, the complex organization of transient cognitive networks is typically not characterized within the graph theory framework. Thus, it is not known whether cognitive processing merely changes the strength of functional connections or, conversely, requires qualitatively new topological arrangements of functional networks. To address this question, we recorded high-density EEG while subjects performed a visual discrimination task. We conducted an event-related network analysis (ERNA) where source-space weighted functional networks were characterized with graph measures. ERNA revealed rapid, transient, and frequency-specific reorganization of the network's topology during cognition. Specifically, cognitive networks were characterized by strong clustering, low modularity, and strong interactions between hub-nodes. Our findings suggest that dense and clustered connectivity between the hub nodes belonging to different modules is the "network fingerprint" of cognition. Such reorganization patterns might facilitate global integration of information and provide a substrate for a "global workspace" necessary for cognition and consciousness to occur. Thus, characterizing topology of the event-related networks opens new vistas to interpret cognitive dynamics in the broader conceptual framework of graph theory.

  17. Anthropogenic Reorganization of Critical Zone in Intensively Managed Landscapes

    NASA Astrophysics Data System (ADS)

    Kumar, P.; Anders, A. M.; Bettis, E. A., III; Blair, N. E.; Filley, T. R.; Grimley, D. A.; Le, P. V.; Lin, H.; Lin, Y. F. F.; Keefer, D. A.; Keefer, L. L.; Muste, M.; Packman, A. I.; Papanicolaou, T.; Rhoads, B. L.; Richardson, M.; Schnoebelen, D. J.; Stumpf, A.; Ward, A. S.; Wilson, C. G.; Woo, D.; Yan, Q.; Goodwell, A. E.

    2016-12-01

    Intensification of industrial agricultural practices has resulted in some of the most profound global impacts in the Anthropocene. These include eutrophication of lakes, rivers, and oceans from nutrient loading, degradation of arable land from the loss of fertile organic soils through erosion, and loss and degradation of soil organic matter from mechanical impacts on the soil, among others. As we prepare to feed additional 2 billion people by 2050 along with the emerging practices of farming for bioenergy production, these practices will intensify further whose goal is to overcome bio-geo-physical rate limitations and rate limiting states to enhance agricultural productivity. These rate-enhancing efforts generally target the fast response production processes, creating an imbalance with the slower assimilative processes in the Critical Zone that cascade through complex inter-dependencies across carbon, soil, water, nutrient and ecological systems. These imbalances modify stores and create gradients for flux, which over time reorganize the landscape, both in structure and function. In this presentation we show how these reorganizations are occurring in the Critical Zone of intensively managed landscapes, and argue that an integrated understanding of such profound changes are necessary for developing sustainable solutions for maintaining agricultural productivity and mitigating agriculture based environmental impacts.

  18. Nanoscale Molecular Reorganization of the Inhibitory Postsynaptic Density Is a Determinant of GABAergic Synaptic Potentiation.

    PubMed

    Pennacchietti, Francesca; Vascon, Sebastiano; Nieus, Thierry; Rosillo, Christian; Das, Sabyasachi; Tyagarajan, Shiva K; Diaspro, Alberto; Del Bue, Alessio; Petrini, Enrica Maria; Barberis, Andrea; Cella Zanacchi, Francesca

    2017-02-15

    Gephyrin is a key scaffold protein mediating the anchoring of GABAA receptors at inhibitory synapses. Here, we exploited superresolution techniques combined with proximity-based clustering analysis and model simulations to investigate the single-molecule gephyrin reorganization during plasticity of inhibitory synapses in mouse hippocampal cultured neurons. This approach revealed that, during the expression of inhibitory LTP, the increase of gephyrin density at postsynaptic sites is associated with the promoted formation of gephyrin nanodomains. We demonstrate that the gephyrin rearrangement in nanodomains stabilizes the amplitude of postsynaptic currents, indicating that, in addition to the number of synaptic GABAA receptors, the nanoscale distribution of GABAA receptors in the postsynaptic area is a crucial determinant for the expression of inhibitory synaptic plasticity. In addition, the methodology implemented here clears the way to the application of the graph-based theory to single-molecule data for the description and quantification of the spatial organization of the synapse at the single-molecule level.SIGNIFICANCE STATEMENT The mechanisms of inhibitory synaptic plasticity are poorly understood, mainly because the size of the synapse is below the diffraction limit, thus reducing the effectiveness of conventional optical and imaging techniques. Here, we exploited superresolution approaches combined with clustering analysis to study at unprecedented resolution the distribution of the inhibitory scaffold protein gephyrin in response to protocols inducing LTP of inhibitory synaptic responses (iLTP). We found that, during the expression of iLTP, the increase of synaptic gephyrin is associated with the fragmentation of gephyrin in subsynaptic nanodomains. We demonstrate that such synaptic gephyrin nanodomains stabilize the amplitude of inhibitory postsynaptic responses, thus identifying the nanoscale gephyrin rearrangement as a key determinant for inhibitory

  19. Feelings of betrayal by the United Nations High Commissioner for Refugees and emotionally distressed Sudanese refugees in Cairo.

    PubMed

    Meffert, Susan M; Musalo, Karen; Abdo, Akram Osman; Alla, Omayma Ahmed Abd; Elmakki, Yasir Omer Mustafa; Omer, Afrah Abdelrahim; Yousif, Sahar; Metzler, Thomas J; Marmar, Charles R

    2010-01-01

    Thousands of Sudanese refugees have fled to Cairo, Egypt in the wake of Sudanese civil conflicts. Sudanese refugees were evaluated with respect to symptoms of depression, post-traumatic stress disorder (PTSD) and social stress. Four respondents (22%) indicated that their interactions with the United Nations High Commissioner for Refugees (UNHCR) in Cairo, Egypt were the worst experiences since war-related atrocities. Fourteen participants (63.6%) felt 'extremely' betrayed by the UNHCR on a four point scale. Greater feelings of betrayal by the UNHCR were associated with greater avoidance and arousal symptoms of PTSD, symptoms of depression and trait anger. This is the first study of which we are aware that examines the relationship between sense of betrayal by the UNHCR and symptoms of PTSD, depression and anger among asylum seekers.

  20. Neglected roots of regionalism? The Commissioners for the special areas and grants to hospital services in the 1930s.

    PubMed

    Mohan, J

    1997-08-01

    The inter-war years in the UK were notable for debates about the extent to which an extension of state intervention in hospital provision was desirable and necessary, and about the limits to and future of the voluntary hospital system which relied largely on various forms of private charity. These themes were intertwined in the UK's 'Special Areas', locations recognized as having suffered adversely from the inter-war depression, with consequent effects on their ability to finance desirable investments in social infrastructures. Grant aid was offered to hospitals in these locations under the terms of the Special Areas legislation of 1934, but there were extensive debates about the principle and practice of such subsidies to hospital development. This paper reviews these debates and considers whether the measures taken by the Commissioners can be seen as neglected antecedents of the regionalism detected in British hospital policy by several commentators.

  1. Violence, Vandalism and Substance Abuse in New Jersey Public Schools. The Commissioner's Annual Report to the Education Committees of the Senate and General Assembly, 2003-2004

    ERIC Educational Resources Information Center

    New Jersey Department of Education, 2005

    2005-01-01

    The Commissioner's report provides the Legislature with data in four broad categories of incidents: violence, vandalism, weapons and substance abuse. Analysis of trends yields indications of progress and of concern and provides guidance to the department as it endeavors to focus its resources appropriately. In this report, the department also…

  2. The Public Schools of Columbia, South Carolina. Report of a Survey Made under the Direction of the Commissioner of Education. Bulletin, 1918, No. 28

    ERIC Educational Resources Information Center

    Bureau of Education, Department of the Interior, 1918

    1918-01-01

    The survey committee of the United States Bureau of Education brings to Columbia, South Carolina's attention those practices which are generally held by other communities, for the present, at least, to be the best. In its effort to get at the facts it has received the unhesitating cooperation of the school commissioners, the superintendent, and…

  3. Plate Reorganizations in the Context of Earth's Thermal Evolution

    NASA Astrophysics Data System (ADS)

    Evans, D. A.; Korenaga, J.

    2004-05-01

    Global isotopic age peaks have suggested four major episodes of supercontinental assembly throughout Earth history: 2700 Ma (assembly of Kenorland), 2100-1800 Ma (Nuna), 1300-1100 Ma (Rodinia), and 600-300 Ma (Gondwanaland-Pangea). Assembly of the next supercontinent is ongoing as Asia acquires landmasses to grow into Super-Asia. Because the configurations of Precambrian supercontinents are poorly understood, there is great difficulty in evaluating the dynamic processes controlling their amalgamations and disaggregations. Most kinematic models of the Rodinia-Gondwanaland transition invoke substantial toroidal motion of continental blocks crossing a Tethys-like ocean; however, a new, alternative model of Rodinia (Evans, 2004, Intl Geol Congress) suggests that predominantly poloidal motion characterized the Neoproterozoic transition to Gondwanaland. The new Rodinia reconstruction also suggests that its assembly was almost complete by 1800 Ma (Nuna supercontinent), and that only minor additions joined the landmass during "Grenvillian" time (1300-1100 Ma). If true, then Earth has experienced a more fitful history of plate reorganizations, rather than the quasi-regular periodicity suggested by the isotopic age peaks cited above. Supercontinental breakup intervals would then be limited to 2450-2100 Ga (Kenorland), 830-615 Ma (Rodinia), and 200-60 Ma (Gondwanaland-Pangea). In this view, accelerating tempo of plate reorganizations would appear at odds with standard thermal evolution models of the Earth, which contend that greater rates of plate reorganization should be found in the distant past. A more thorough perspective on global plate rates in the milieu of higher global heat flow (Korenaga, 2003, Fall AGU) suggests that past plate rates should be limited by bending resistance of subducting slabs, which in early Earth history would have been greater due to a deeper zone of melt extraction and dehydration at primitive mid-ocean ridges. In other words, despite a steady

  4. Childhood obesity case statement.

    PubMed

    Esposito, Paul W; Caskey, Paul; Heaton, Lisa E; Otsuka, Norman

    2014-01-01

    The goal of this publication is to raise awareness of the impact of childhood obesity on the musculoskeletal health of children and its potential long-term implications. Relevant articles dealing with musculoskeletal disorders either caused by or worsened by childhood obesity were reviewed through a Pub Med search. Efforts to recognize and combat the childhood obesity epidemic were also identified through Internet search engines. This case statement was then reviewed by the members of the pediatric specialty group of the US Bone and Joint Initiative, which represents an extensive number of organizations dealing with musculoskeletal health. Multiple musculoskeletal disorders are clearly caused by or worsened by childhood obesity. The review of the literature clearly demonstrates the increased frequency and severity of many childhood musculoskeletal disorders. Concerns about the long-term implications of these childhood onset disorders such as pain and degenerative changes into adulthood are clearly recognized by all the member organizations of the US Bone and Joint Initiative. It is imperative to recognize the long-term implications of musculoskeletal disorders caused by or worsened by childhood obesity. It is also important to recognize that the ability to exercise comfortably is a key factor to developing a healthy lifestyle and maintaining a healthy body weight. Efforts to develop reasonable and acceptable programs to increase physical activity by all facets of society should be supported. Further research into the long-term implications of childhood musculoskeletal disorders related to childhood obesity is necessary.

  5. Childhood obesity case statement.

    PubMed

    Esposito, Paul W; Caskey, Paul; Heaton, Lisa E; Otsuka, Norman

    2013-04-01

    The goal of this publication is to raise awareness of the impact of childhood obesity on the musculoskeletal health of children and its potential long-term implications. Relevant articles dealing with musculoskeletal disorders either caused by or worsened by childhood obesity were reviewed through a Pub Med search. Efforts to recognize and combat the childhood obesity epidemic were also identified through Internet search engines. This case statement was then reviewed by the members of the pediatric specialty group of the US Bone and Joint Initiative, which represents an extensive number of organizations dealing with musculoskeletal health. Multiple musculoskeletal disorders are clearly caused by or worsened by childhood obesity. The review of the literature clearly demonstrates the increased frequency and severity of many childhood musculoskeletal disorders. Concerns about the long-term implications of these childhood onset disorders such as pain and degenerative changes into adulthood are clearly recognized by all the member organizations of the US Bone and Joint Initiative. It is imperative to recognize the long-term implications of musculoskeletal disorders caused by or worsened by childhood obesity. It is also important to recognize that the ability to exercise comfortably is a key factor to developing a healthy lifestyle and maintaining a healthy body weight. Efforts to develop reasonable and acceptable programs to increase physical activity by all facets of society should be supported. Further research into the long-term implications of childhood musculoskeletal disorders related to childhood obesity is necessary. Copyright © 2013 Elsevier Inc. All rights reserved.

  6. Statement on intrauterine devices.

    PubMed

    1981-12-01

    These policy statements and guidelines from the International Planned Parenthood Federation's (IPPF) International Medical Advisory Panel (IMAP) concern IUDs. The following contraindications to IUD use are recognized: 1) pelvic inflaminatory disease, 2) known or suspected pregnancy, 3) history of previous ectopic pregnancy, 4) gynecological bleeding disorders, 5) suspected malignancy of the genital tract, 6) congenital uterine abnormalities or fibroids distorting the cavity, and 7) anemia, blood coagulation, severe cervical stenosis, copper allergy, Wilson's disease, and others. Generalities regarding appropriate IUDs are: 1) non-medicated devices (e.g. Lippes Loop) are studied for women who may not return for regular check-ups, 2) smaller medicated devices usually cause less menstrual blood loss than the non-medicated devices, 3) smaller devices are better for a smaller uterus and larger devices for the larger uterus, and 4) when a smaller device is expelled it is advisable to try a larger one and vice versa. Dalkon Shields should not be used by the IPPF system and all women using them should have the device removed. Correct insertion of IUDs is important and should be done by properly trained personnel. The timing of insertion is best during the menstrual period. Withdrawal of the applicator while leaving the device in place is the recommended insertion technique. Sterilization of IUDs should follow instructions on bulk-packaged IUDs. Complications include perforation, bleeding and pain, infection, and ectopic pregnancy. IUD removal should be done during menstruation. Good clinical management and follow-up care are recommended.

  7. Environmental Impact Statement Filing Guidance

    EPA Pesticide Factsheets

    Describes how to submit an environmental impact statement through the e-NEPA electronic submission system. Describes how EPA submits a notice of availability in to the Federal Register and how the comment time period if set forth.

  8. Pajaro Dunes Conference Draft Statement.

    ERIC Educational Resources Information Center

    Journal of College and University Law, 1982

    1982-01-01

    A statement of concerns and needs in the relationship between universities and industry for biomedical research addresses the issues of research agreements and their terms, patent licensing, university and faculty roles, and establishment of policy and procedures. (MSE)

  9. It's Time to Implement GASB Statement 54

    ERIC Educational Resources Information Center

    Heinfeld, Gary; Nuehring, Bert

    2012-01-01

    In February 2009, the Governmental Accounting Standards Board (GASB) issued Statement No. 54, "Find Balance Reporting and Governmental Fund Type Definitions." This statement changes how a fund balance is classified on the face of the government fund financial statements and refines the definitions for government fund types. The statement's…

  10. GASB Statement No. 3 Guides Deposits, Investments.

    ERIC Educational Resources Information Center

    Barker, Linda A.

    1986-01-01

    Discusses an April 1986 Governmental Accounting Standards Board statement concerning disclosures of repurchase and reverse repurchase agreements. The statement tries to help financial statement users assess the risks a goverment entity takes when investing public funds. It is effective for financial statement periods ending after December 15,…

  11. 7 CFR 4279.137 - Financial statements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Financial statements. 4279.137 Section 4279.137... § 4279.137 Financial statements. (a) The lender will determine the type and frequency of submission of financial statements by the borrower. At a minimum, annual financial statements prepared by an accountant in...

  12. 7 CFR 4279.137 - Financial statements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Financial statements. 4279.137 Section 4279.137... § 4279.137 Financial statements. (a) The lender will determine the type and frequency of submission of financial statements by the borrower. At a minimum, annual financial statements prepared by an accountant in...

  13. 7 CFR 4279.137 - Financial statements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Financial statements. 4279.137 Section 4279.137... § 4279.137 Financial statements. (a) The lender will determine the type and frequency of submission of financial statements by the borrower. At a minimum, annual financial statements prepared by an accountant in...

  14. 7 CFR 1221.113 - Financial statements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Financial statements. 1221.113 Section 1221.113... Information Board § 1221.113 Financial statements. (a) As requested by the Secretary, the Board shall prepare and submit financial statements to the Secretary on a monthly basis. Each such financial statement...

  15. 7 CFR 1221.113 - Financial statements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Financial statements. 1221.113 Section 1221.113... Information Board § 1221.113 Financial statements. (a) As requested by the Secretary, the Board shall prepare and submit financial statements to the Secretary on a monthly basis. Each such financial statement...

  16. 29 CFR 99.310 - Financial statements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Financial statements. 99.310 Section 99.310 Labor Office of....310 Financial statements. (a) Financial statements. The auditee shall prepare financial statements that reflect its financial position, results of operations or changes in net assets, and,...

  17. 38 CFR 41.310 - Financial statements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Financial statements. 41...) AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditees § 41.310 Financial statements. (a) Financial statements. The auditee shall prepare financial statements that reflect its...

  18. 7 CFR 4279.137 - Financial statements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Financial statements. 4279.137 Section 4279.137... § 4279.137 Financial statements. (a) The lender will determine the type and frequency of submission of financial statements by the borrower. At a minimum, annual financial statements prepared by an accountant...

  19. 38 CFR 41.310 - Financial statements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Financial statements. 41...) AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditees § 41.310 Financial statements. (a) Financial statements. The auditee shall prepare financial statements that reflect its...

  20. 29 CFR 99.310 - Financial statements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Financial statements. 99.310 Section 99.310 Labor Office of....310 Financial statements. (a) Financial statements. The auditee shall prepare financial statements that reflect its financial position, results of operations or changes in net assets, and,...

  1. 7 CFR 4279.137 - Financial statements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Financial statements. 4279.137 Section 4279.137... § 4279.137 Financial statements. (a) The lender will determine the type and frequency of submission of financial statements by the borrower. At a minimum, annual financial statements prepared by an accountant...

  2. It's Time to Implement GASB Statement 54

    ERIC Educational Resources Information Center

    Heinfeld, Gary; Nuehring, Bert

    2012-01-01

    In February 2009, the Governmental Accounting Standards Board (GASB) issued Statement No. 54, "Find Balance Reporting and Governmental Fund Type Definitions." This statement changes how a fund balance is classified on the face of the government fund financial statements and refines the definitions for government fund types. The statement's…

  3. 26 CFR 1.358-6 - Stock basis in certain triangular reorganizations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... purposes of this section— (i) P is a corporation— (A) That is a party to a reorganization, (B) That is in... reorganization, and (B) That is controlled by P. (iii) T is a corporation that is another party to the...) directly from T in a transaction in which P's basis in the T assets was determined under section...

  4. 26 CFR 1.358-6 - Stock basis in certain triangular reorganizations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... purposes of this section— (i) P is a corporation— (A) That is a party to a reorganization, (B) That is in... reorganization, and (B) That is controlled by P. (iii) T is a corporation that is another party to the...) directly from T in a transaction in which P's basis in the T assets was determined under section...

  5. 26 CFR 1.358-6 - Stock basis in certain triangular reorganizations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... purposes of this section— (i) P is a corporation— (A) That is a party to a reorganization, (B) That is in... reorganization, and (B) That is controlled by P. (iii) T is a corporation that is another party to the...) directly from T in a transaction in which P's basis in the T assets was determined under section...

  6. 29 CFR Appendix A to Part 24 - Your Rights Under the Energy Reorganization Act

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Your Rights Under the Energy Reorganization Act A Appendix A to Part 24 Labor Office of the Secretary of Labor PROCEDURES FOR THE HANDLING OF RETALIATION... the Energy Reorganization Act ER10AU07.000...

  7. 77 FR 65361 - Reorganization/Expansion of Foreign-z Under Alternative Site Framework; Galveston, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-26

    ...; Galveston, TX Pursuant to its authority under the Foreign-Trade Zones Act of June 18, 1934, as amended (19 U... or reorganization of zones; Whereas, the Board of Trustees of the Galveston Wharves, grantee of... authority to reorganize under the ASF with a service area of Galveston County, Texas, within and adjacent to...

  8. 78 FR 1197 - Reorganization of Foreign-Trade Zone 32 Under Alternative Site Framework; Miami, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... Foreign-Trade Zones Board Reorganization of Foreign-Trade Zone 32 Under Alternative Site Framework; Miami... adopted the alternative site framework (ASF) (15 CFR Sec. 400.2(c)) as an option for the establishment or... orders: The application, as amended, to reorganize FTZ 32 under the alternative site framework is...

  9. Strategies for Reorganization in Allied Health and Nursing Programs: The Endless Metamorphosis.

    ERIC Educational Resources Information Center

    Scigliano, Virginia; Scigliano, John A.

    Four alternative organizational structures are discussed with regard to their applicability to the reorganization of community college allied health programs. After introductory material noting the complexities, multiple interfaces, and high costs that make allied health and nursing programs prime targets for reorganization, the four models of…

  10. 78 FR 60695 - Regulatory Reorganization; Administrative Changes to Regulations Due to the Consolidation of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ... Reorganization; Administrative Changes to Regulations Due to the Consolidation of the Financial Management... consolidated the bureaus formerly known as the Financial Management Service (``FMS'') and the Bureau of the... consolidation requires reorganization of, and administrative changes to, title 31 of the Code of...

  11. 77 FR 6059 - Reorganization of Foreign-Trade Zone 275 Under Alternative Site Framework; Lansing, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... Foreign-Trade Zones Board Reorganization of Foreign-Trade Zone 275 Under Alternative Site Framework... Board adopted the alternative site framework (ASF) (74 FR 1170, 01/12/09; correction 74 FR 3987, 01/22... to reorganize FTZ 275 under the alternative site framework is approved, subject to the FTZ Act...

  12. 77 FR 6058 - Reorganization of Foreign-Trade Zone 118 Under Alternative Site Framework, Ogdensburg, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... Foreign-Trade Zones Board Reorganization of Foreign-Trade Zone 118 Under Alternative Site Framework... Board adopted the alternative site framework (ASF) (74 FR 1170, 01/12/2009; correction 74 FR 3987, 01/22... to reorganize FTZ 118 under the alternative site framework is approved, subject to the FTZ Act...

  13. 29 CFR 24.114 - District court jurisdiction of retaliation complaints under the Energy Reorganization Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Provisions § 24.114 District court jurisdiction of retaliation complaints under the Energy Reorganization Act... 29 Labor 1 2010-07-01 2010-07-01 true District court jurisdiction of retaliation complaints under the Energy Reorganization Act. 24.114 Section 24.114 Labor Office of the Secretary of Labor...

  14. 26 CFR 1.167(l)-3 - Multiple regulation, asset acquisitions, reorganizations, etc.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., reorganizations, etc. 1.167(l)-3 Section 1.167(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... and Corporations § 1.167(l)-3 Multiple regulation, asset acquisitions, reorganizations, etc. (a... uses a method of depreciation other than a subsection (l) method of depreciation is required by...

  15. Limitations to Plasticity of Language Network Reorganization in Localization Related Epilepsy

    ERIC Educational Resources Information Center

    Mbwana, J.; Berl, M. M.; Ritzl, E. K.; Rosenberger, L.; Mayo, J.; Weinstein, S.; Conry, J. A.; Pearl, P. L.; Shamim, S.; Moore, E. N.; Sato, S.; Vezina, L. G.; Theodore, W. H.; Gaillard, W. D.

    2009-01-01

    Neural networks for processing language often are reorganized in patients with epilepsy. However, the extent and location of within and between hemisphere re-organization are not established. We studied 45 patients, all with a left hemisphere seizure focus (mean age 22.8, seizure onset 13.3), and 19 normal controls (mean age 24.8) with an fMRI…

  16. Cortical microtubule reorganization in protoplasts isolated from Brassica napus hypocotyl is affected by gravity.

    PubMed

    Skagen, E B

    1998-07-01

    Researchers studied the effect of simulated weightlessness on the reorganization of cortical microtubules in Brassica napus hypocotyl protoplasts. The reorganization of cortical microtubules in protoplasts exposed to simulated weightlessness was examined using a fast rotating one-axis clinostat for 1-4 days and with a three dimensional clinostat and a free fall machine for 48 hours.

  17. 26 CFR 1.167(l)-3 - Multiple regulation, asset acquisitions, reorganizations, etc.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., reorganizations, etc. 1.167(l)-3 Section 1.167(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... and Corporations § 1.167(l)-3 Multiple regulation, asset acquisitions, reorganizations, etc. (a... uses a method of depreciation other than a subsection (l) method of depreciation is required by a...

  18. 26 CFR 1.167(l)-3 - Multiple regulation, asset acquisitions, reorganizations, etc.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., reorganizations, etc. 1.167(l)-3 Section 1.167(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... and Corporations § 1.167(l)-3 Multiple regulation, asset acquisitions, reorganizations, etc. (a... uses a method of depreciation other than a subsection (l) method of depreciation is required by a...

  19. 26 CFR 1.167(l)-3 - Multiple regulation, asset acquisitions, reorganizations, etc.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., reorganizations, etc. 1.167(l)-3 Section 1.167(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... and Corporations § 1.167(l)-3 Multiple regulation, asset acquisitions, reorganizations, etc. (a... uses a method of depreciation other than a subsection (l) method of depreciation is required by a...

  20. 26 CFR 1.167(l)-3 - Multiple regulation, asset acquisitions, reorganizations, etc.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., reorganizations, etc. 1.167(l)-3 Section 1.167(l)-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE... and Corporations § 1.167(l)-3 Multiple regulation, asset acquisitions, reorganizations, etc. (a... uses a method of depreciation other than a subsection (l) method of depreciation is required by a...

  1. 29 CFR Appendix A to Part 24 - Your Rights Under the Energy Reorganization Act

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Your Rights Under the Energy Reorganization Act A Appendix A to Part 24 Labor Office of the Secretary of Labor PROCEDURES FOR THE HANDLING OF RETALIATION... ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Pt. 24, App. A Appendix A to Part 24—Your Rights Under...

  2. Hunting promotes spatial reorganization and sexually selected infanticide

    PubMed Central

    Leclerc, M.; Frank, S. C.; Zedrosser, A.; Swenson, J. E.; Pelletier, F.

    2017-01-01

    Harvest can affect the ecology and evolution of wild species. The removal of key individuals, such as matriarchs or dominant males, can disrupt social structure and exacerbate the impact of hunting on population growth. We do not know, however, how and when the spatiotemporal reorganization takes place after removal and if such changes can be the mechanism that explain a decrease in population growth. Detailed behavioral information from individually monitored brown bears, in a population where hunting increases sexually selected infanticide, revealed that adult males increased their use of home ranges of hunter-killed neighbors in the second year after their death. Use of a hunter-killed male’s home range was influenced by the survivor’s as well as the hunter-killed male’s age, population density, and hunting intensity. Our results emphasize that hunting can have long-term indirect effects which can affect population viability. PMID:28332613

  3. Reorganization between preparatory and movement population responses in motor cortex

    PubMed Central

    Elsayed, Gamaleldin F.; Lara, Antonio H.; Kaufman, Matthew T.; Churchland, Mark M.; Cunningham, John P.

    2016-01-01

    Neural populations can change the computation they perform on very short timescales. Although such flexibility is common, the underlying computational strategies at the population level remain unknown. To address this gap, we examined population responses in motor cortex during reach preparation and movement. We found that there exist exclusive and orthogonal population-level subspaces dedicated to preparatory and movement computations. This orthogonality yielded a reorganization in response correlations: the set of neurons with shared response properties changed completely between preparation and movement. Thus, the same neural population acts, at different times, as two separate circuits with very different properties. This finding is not predicted by existing motor cortical models, which predict overlapping preparation-related and movement-related subspaces. Despite orthogonality, responses in the preparatory subspace were lawfully related to subsequent responses in the movement subspace. These results reveal a population-level strategy for performing separate but linked computations. PMID:27807345

  4. Hunting promotes spatial reorganization and sexually selected infanticide.

    PubMed

    Leclerc, M; Frank, S C; Zedrosser, A; Swenson, J E; Pelletier, F

    2017-03-23

    Harvest can affect the ecology and evolution of wild species. The removal of key individuals, such as matriarchs or dominant males, can disrupt social structure and exacerbate the impact of hunting on population growth. We do not know, however, how and when the spatiotemporal reorganization takes place after removal and if such changes can be the mechanism that explain a decrease in population growth. Detailed behavioral information from individually monitored brown bears, in a population where hunting increases sexually selected infanticide, revealed that adult males increased their use of home ranges of hunter-killed neighbors in the second year after their death. Use of a hunter-killed male's home range was influenced by the survivor's as well as the hunter-killed male's age, population density, and hunting intensity. Our results emphasize that hunting can have long-term indirect effects which can affect population viability.

  5. Exposure therapy triggers lasting reorganization of neural fear processing.

    PubMed

    Hauner, Katherina K; Mineka, Susan; Voss, Joel L; Paller, Ken A

    2012-06-05

    A single session of exposure therapy can eliminate recalcitrant and disabling fear of phobogenic objects or situations. We studied neural mechanisms of this remarkable outcome by monitoring changes in brain activity as a result of successful 2-h treatment. Before treatment, phobogenic images excited activity in a network of regions, including amygdala, insula, and cingulate cortex, relative to neutral images. Successful therapy dampened responsiveness in this fear-sensitive network while concomitantly heightening prefrontal involvement. Six months later, dampened fear-network activity persisted but without prefrontal engagement. Additionally, individual differences in the magnitude of visual cortex activations recorded shortly after therapy predicted therapeutic outcomes 6 mo later, which involved persistently diminished visual responsiveness to phobogenic images. Successful therapy thus entailed stable reorganization of neural responses to initially feared stimuli. These effects were linked to fear-extinction mechanisms identified in animal models, thus opening new opportunities for the treatment and prevention of debilitating anxiety disorders.

  6. Reorganization of a granular medium around a localized transformation

    NASA Astrophysics Data System (ADS)

    Merceron, Aymeric; Sauret, Alban; Jop, Pierre

    2016-06-01

    Physical and chemical transformation processes in reactive granular media involve the reorganization of the structure. In this paper, we study experimentally the rearrangements of a two-dimensional (2D) granular packing undergoing a localized transformation. We track the position and evolution of all the disks that constitute the granular packing when either a large intruder shrinks in size or is pulled out of the granular structure. In the two situations the displacements at long time are similar to 2D quasistatic silo flows whereas the short-time dynamic is heterogeneous in both space and time. We observe an avalanchelike behavior with power-law distributed events uncorrelated in time. In addition, the instantaneous evolutions of the local solid fraction exhibit self-similar distributions. The averages and the standard deviations of the solid fraction variations can be rescaled, suggesting a single mechanism of rearrangement.

  7. Reorganization of a granular medium around a localized transformation.

    PubMed

    Merceron, Aymeric; Sauret, Alban; Jop, Pierre

    2016-06-01

    Physical and chemical transformation processes in reactive granular media involve the reorganization of the structure. In this paper, we study experimentally the rearrangements of a two-dimensional (2D) granular packing undergoing a localized transformation. We track the position and evolution of all the disks that constitute the granular packing when either a large intruder shrinks in size or is pulled out of the granular structure. In the two situations the displacements at long time are similar to 2D quasistatic silo flows whereas the short-time dynamic is heterogeneous in both space and time. We observe an avalanchelike behavior with power-law distributed events uncorrelated in time. In addition, the instantaneous evolutions of the local solid fraction exhibit self-similar distributions. The averages and the standard deviations of the solid fraction variations can be rescaled, suggesting a single mechanism of rearrangement.

  8. Dynamic Reorganization of Neuronal Activity Patterns in Parietal Cortex.

    PubMed

    Driscoll, Laura N; Pettit, Noah L; Minderer, Matthias; Chettih, Selmaan N; Harvey, Christopher D

    2017-08-24

    Neuronal representations change as associations are learned between sensory stimuli and behavioral actions. However, it is poorly understood whether representations for learned associations stabilize in cortical association areas or continue to change following learning. We tracked the activity of posterior parietal cortex neurons for a month as mice stably performed a virtual-navigation task. The relationship between cells' activity and task features was mostly stable on single days but underwent major reorganization over weeks. The neurons informative about task features (trial type and maze locations) changed across days. Despite changes in individual cells, the population activity had statistically similar properties each day and stable information for over a week. As mice learned additional associations, new activity patterns emerged in the neurons used for existing representations without greatly affecting the rate of change of these representations. We propose that dynamic neuronal activity patterns could balance plasticity for learning and stability for memory. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Large-Scale Functional Brain Network Reorganization During Taoist Meditation.

    PubMed

    Jao, Tun; Li, Chia-Wei; Vértes, Petra E; Wu, Changwei Wesley; Achard, Sophie; Hsieh, Chao-Hsien; Liou, Chien-Hui; Chen, Jyh-Horng; Bullmore, Edward T

    2016-02-01

    Meditation induces a distinct and reversible mental state that provides insights into brain correlates of consciousness. We explored brain network changes related to meditation by graph theoretical analysis of resting-state functional magnetic resonance imaging data. Eighteen Taoist meditators with varying levels of expertise were scanned using a within-subjects counterbalanced design during resting and meditation states. State-related differences in network topology were measured globally and at the level of individual nodes and edges. Although measures of global network topology, such as small-worldness, were unchanged, meditation was characterized by an extensive and expertise-dependent reorganization of the hubs (highly connected nodes) and edges (functional connections). Areas of sensory cortex, especially the bilateral primary visual and auditory cortices, and the bilateral temporopolar areas, which had the highest degree (or connectivity) during the resting state, showed the biggest decrease during meditation. Conversely, bilateral thalamus and components of the default mode network, mainly the bilateral precuneus and posterior cingulate cortex, had low degree in the resting state but increased degree during meditation. Additionally, these changes in nodal degree were accompanied by reorganization of anatomical orientation of the edges. During meditation, long-distance longitudinal (antero-posterior) edges increased proportionally, whereas orthogonal long-distance transverse (right-left) edges connecting bilaterally homologous cortices decreased. Our findings suggest that transient changes in consciousness associated with meditation introduce convergent changes in the topological and spatial properties of brain functional networks, and the anatomical pattern of integration might be as important as the global level of integration when considering the network basis for human consciousness.

  10. Correlation between cerebral reorganization and motor recovery after subcortical infarcts.

    PubMed

    Loubinoux, Isabelle; Carel, Christophe; Pariente, Jérémie; Dechaumont, Sophie; Albucher, Jean-François; Marque, Philippe; Manelfe, Claude; Chollet, François

    2003-12-01

    Our objective was to investigate correlations between clinical motor scores and cerebral sensorimotor activation to demonstrate that this reorganization is the neural substratum of motor recovery. Correlation analyses identified reorganization processes shared by all patients. Nine patients with first-time corticospinal tract lacuna were clinically evaluated using the NIH stroke scale, the motricity index, and the Barthel index. Patients were strictly selected for pure motor deficits. They underwent a first fMRI session (E1) 11 days after stroke, and then a second (E2) 4 weeks later. The task used was a calibrated repetitive passive flexion/extension of the paretic wrist. The control task was rest. Six healthy subjects followed the same protocol. Patients were also clinically evaluated 4 and 12 months after stroke. All patients improved significantly between E1 and E2. For E1 and E2, the ipsilesional primary sensorimotor and premotor cortex, supplementary motor area (SMA), and bilateral Broadmann area (BA) 40 were activated. Activation intensity was greater at the second examination except in the ipsilesional superior BA 40. Magnitude of activation was lower than that of controls except for well-recovered patients. E1 clinical hand motor score and E1 cerebral activation correlated in the SMA proper and inferior ipsilesional BA 40. Thus, we demonstrated early functionality of the sensorimotor system. The whole sensorimotor network activation correlated with motor status at E2, indicating a recovery of its function when activated. Moreover, the activation pattern in the acute phase (E1) had a predictive value: early recruitment and high activation of the SMA and inferior BA 40 were correlated with a faster or better motor recovery. On the contrary, activation of the contralesional hemisphere (prefrontal cortex and BA 39-40) and of the posterior cingulate/precuneus (BA 7-31) predicted a slower recovery.

  11. Thalamic Reorganization in Chronic Patients With Intracerebral Hemorrhage

    PubMed Central

    Jang, Sung Ho; Chang, Chul Hoon; Kim, Seong Ho; Jung, Young Jin; Hong, Ji Heon

    2015-01-01

    Abstract The aim of this study was to investigate changes of synaptic area of the spinothalamic tract and its thalamocortical pathway (STT) in the thalamus in chronic patients with putaminal hemorrhage. Twenty four patients with a lesion in the ventral posterior lateral nucleus (VPL) of the thalamus following putaminal hemorrhage were recruited for this study. The subscale for tactile sensation of the Nottingham Sensory Assessment (NSA) was used for the determination of somatosensory function. Diffusion tensor tractography of the STT was reconstructed using the Functional Magnetic Resonance Imaging of the Brain Software Library. We classified patients according to 2 groups: the VPL group, patients whose STTs were synapsed in the VPL; and the non-VPL group, patients whose STTs were synapsed in other thalamic areas, except for the VPL. Thirteen patients belonged to the VPL group, and 8 patients belonged to the non-VPL group. Three patients were excluded from grouping due to interrupted integrity of the STTs. The tactile sensation score of the NSA in the non-VPL group (10.50 ± 0.93) was significantly decreased compared with that of the VPL group (19.45 ± 1.33) (P < 0.05). We found that 2 types of patient had recovered via the VPL area or other areas of the STT. It appears that patients who showed shifting of the thalamic synaptic area of the STT might have recovered by the process of thalamic reorganization following thalamic injury. In addition, thalamic reorganization appears to be related to poorer somatosensory outcome. PMID:26313781

  12. Interhemispheric and intrahemispheric language reorganization in complex partial epilepsy.

    PubMed

    Rosenberger, L R; Zeck, J; Berl, M M; Moore, E N; Ritzl, E K; Shamim, S; Weinstein, S L; Conry, J A; Pearl, P L; Sato, S; Vezina, L G; Theodore, W H; Gaillard, W D

    2009-05-26

    To investigate interhemispheric and intrahemispheric reorganization in patients with localization-related epilepsy. We studied 50 patients with a left hemispheric focus and 20 normal right-handed controls with a 3T echoplanar imaging blood oxygen level dependent functional MRI auditory-based word definition decision task. Data were analyzed using SPM 2. Using region of interest for Broca and Wernicke areas and an asymmetry index (AI), patients were categorized as left language (LL; AI > or = 0.20) or atypical language (AL; AI <0.20) for region. The point maxima activation for normal controls (p <0.05 corrected FDR) was identified in Broca and midtemporal regions and then used as a point of reference for individual point maxima identified at p < 0.001, uncorrected. Patient groups showed increased frequency of having activation in right homologues. Activation in AL groups occurred in homologous right regions; distances for point maxima activation in homologous regions were the same as point maxima distances in normal control activation in left regions. Distances for LL patient in left regions showed a trend for differences for midtemporal gyrus (6 mm posterior, 3 mm superior) but variability around mean difference distance was significant. There was no effect of age at epilepsy onset, duration, or pathology on activation maxima. Right hemisphere language regions in patients with left hemispheric focus are homologues of left hemisphere Broca and broadly defined Wernicke areas. We found little evidence for intrahemispheric reorganization in patients with left hemisphere epilepsy who remain left language dominant by these methods.

  13. Reorganization of actin filament bundles in living fibroblasts

    PubMed Central

    1984-01-01

    We investigated how actin bundles assemble, disassemble, and reorganize during cell movement. Living chick embryonic fibroblasts were microinjected with actin molecules that had been fluorescently labeled with tetramethylrhodamine. We found that the fluorescent analogue of actin can be used successfully by both existing and newly formed cellular structures. Using time-lapse photography coupled to image- intensified fluorescence microscopy, we were able to detect various patterns of reorganization in motile cells. Assembly of stress fibers occurred near both the leading and the trailing ends of the cell. The initial structure appeared as discrete spots that subsequently extended into stress fibers. The extension occurred unidirectionally. The site of initiation near the leading edge remained stationary relative to the substrate during subsequent cell advancement. However, the orientation of the fiber could change according to the direction of cell movement. In addition, existing stress fibers could merge or fragment. The shortening of stress fibers can occur from either end of the fiber. Shortening from the proximal end (centrifugal shortening) was accompanied by a decrease in fluorescence intensity, as if the bundle were disassembling, and usually led to the total disappearance of the bundle. Shortening from the distal end (centripetal shortening), on the other hand, is usually accompanied by an increase in fluorescence intensity at the distal end of the bundle, as if this end had pulled loose from its attachment and retracted toward the center of the cell. Besides stress fibers, arc-like actin bundles have also been detected in spreading cells. These observations can explain how the organization of actin bundles coordinates with cell movement, and how stress fibers reach a highly regular pattern in static cells. PMID:6541223

  14. Multibeam investigation of the active North Atlantic plate boundary reorganization tip

    NASA Astrophysics Data System (ADS)

    Hey, Richard; Martinez, Fernando; Höskuldsson, Ármann; Eason, Deborah E.; Sleeper, Jonathan; Thordarson, Sigvaldi; Benediktsdóttir, Ásdís; Merkuryev, Sergey

    2016-02-01

    The previous orthogonal ridge/transform staircase geometry south of Iceland is being progressively changed to the present continuous oblique Reykjanes Ridge spreading geometry as North America-Eurasia transform faults are successively eliminated from north to south. This reorganization is commonly interpreted as a thermal phenomenon, caused by warmer Iceland plume mantle progressively interacting with the ridge, although other diachronous seafloor spreading reorganizations are thought to result from tectonic rift propagation. New marine geophysical data covering our reinterpretation of the reorganization tip near 57°N show successive transform eliminations at a propagation velocity of ∼110 km/Myr, ten times the spreading half rate, followed by abrupt reorganization slowing at the Modred transform as it was converted to a migrating non-transform offset. Neither the simple thermal model nor the simple propagating rift model appears adequate to explain the complicated plate boundary reorganization process.

  15. 76 FR 76934 - Foreign-Trade Zone 89-Las Vegas, NV; Application for Reorganization and Expansion Under...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-09

    ... Reorganization and Expansion Under Alternative Site Framework An application has been submitted to the Foreign... authority to reorganize and expand the zone under the alternative site framework (ASF) adopted by the...

  16. 26 CFR 1.6046-3 - Returns as to formation or reorganization of foreign corporations prior to September 15, 1960.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 13 2012-04-01 2012-04-01 false Returns as to formation or reorganization of...) Information Returns § 1.6046-3 Returns as to formation or reorganization of foreign corporations prior to... advises in, or with respect to, the formation, organization, or reorganization of any foreign...

  17. 26 CFR 1.6046-3 - Returns as to formation or reorganization of foreign corporations prior to September 15, 1960.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 13 2013-04-01 2013-04-01 false Returns as to formation or reorganization of...) Information Returns § 1.6046-3 Returns as to formation or reorganization of foreign corporations prior to... advises in, or with respect to, the formation, organization, or reorganization of any foreign...

  18. Evidence for cerebellar motor functional reorganization in brain tumor patients: An fMRI study.

    PubMed

    Kurabe, Satoshi; Itoh, Kosuke; Nakada, Tsutomu; Fujii, Yukihiko

    2016-05-27

    Functional reorganization of the motor system following brain damage has been studied extensively in stroke patients, in which not only the cerebrum but also the cerebellum (Cbll) undergoes substantial reorganization. However, the role of Cbll in motor functional reorganization in brain tumor patients remains poorly investigated. Because brain damages in brain tumor patients occur much more slowly than in stroke patients, the neural mechanisms for motor functional reorganization might differ between these two disease conditions. This functional magnetic resonance imaging (fMRI) study investigated whether Cbll constitutes the neural substrates for motor functional reorganization in eighteen supratentorial brain tumor patients who exhibited no clinical signs of paresis. The patients and normal volunteers underwent a unilateral hand movement task. In the patients, the locus of primary sensory motor (SM1) activation during contralesional hand movement was significantly displaced by the tumor, suggesting functional compromise and/or reorganization in the central sulcus region. In addition, their contralesional Cbll activation during contralesional hand movement was substantially increased as compared to normal controls. The finding represents the first conclusive evidence that Cbll is involved in the motor-related functional reorganization in patients with brain tumor. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  19. Downsizing and reorganization: demands, challenges and ambiguity for registered nurses.

    PubMed

    Hertting, Anna; Nilsson, Kerstin; Theorell, Töres; Larsson, Ullabeth Sätterlund

    2004-01-01

    The 1990s were characterized by substantial financial cuts, and related staff redundancies and reorganizations in the Swedish health care sector. A large hospital in Sweden was selected for the study, in which downsizing had occurred between 1995 and 1997. The number of staff in the hospital was reduced by an average of 20%, and 10% were relocated to other departments. The aims of this study were to explore registered nurses' experiences of psychosocial 'stressors' and 'motivators', and how they handled their work situations, following a period of personnel reductions and ongoing reorganization. Interviews were undertaken with 14 nurses working in one Swedish hospital. Nurses were interviewed in 1997 about the recent and last round of redundancies, and were followed up 1 year later in 1998 and again in 2001. Interviews were audiotaped, transcribed and analysed for thematic content. Five themes emerged in relation to nurses' perceived stressors, motivators, and coping options: 'distrust towards the employer', 'concurrent demands and challenges', 'professional ambiguity, 'a wish for collaboration', and 'efforts to gain control'. A common feature was duality and ambiguity in nurses' descriptions of the phenomena studied, meaning that identified themes had underlying sub-themes with both negative and positive dimensions. The concurrence of 'ever-growing job demands' and 'work going unrewarded' contributed to a feeling of being taken advantage of by the employer. The 'waste of human resources' and 'competence drain' that followed redundancies provoked anger. Unfulfilled collaboration with doctors was a major stress producer, which related to both the downsized work organization, and the complex 'deference-dominance' doctor-nurse relationship. The well-being of nurses depends on being an equal/parallel health professional in a comprehensive team that shares knowledge and improves collaborative care of patients. A consciously formulated nursing philosophy emerged as a

  20. Cortical reorganization after macroreplantation at the upper extremity: a magnetoencephalographic study.

    PubMed

    Blume, Kathrin R; Dietrich, Caroline; Huonker, Ralph; Götz, Theresa; Sens, Elisabeth; Friedel, Reinhard; Hofmann, Gunther O; Miltner, Wolfgang H R; Weiss, Thomas

    2014-03-01

    With the development of microsurgical techniques, replantation has become a feasible alternative to stump treatment after the amputation of an extremity. It is known that amputation often induces phantom limb pain and cortical reorganization within the corresponding somatosensory areas. However, whether replantation reduces the risk of comparable persisting pain phenomena as well as reorganization of the primary somatosensory cortex is still widely unknown. Therefore, the present study aimed to investigate the potential development of persistent pain and cortical reorganization of the hand and lip areas within the sensory cortex by means of magnetoencephalographic dipole analyses after replantation of a traumatically amputated upper limb proximal to the radiocarpal joint. Cortical reorganization was investigated in 13 patients with limb replantation using air puff stimulation of the phalanges of both thumbs and both corners of the lower lip. Displacement of the centre of gravity of lip and thumb representations and increased cortical activity were found in the limb and face areas of the primary somatosensory cortex contralateral to the replanted arm when compared to the ipsilateral hemisphere. Thus, cortical reorganization in the primary somatosensory cortex also occurs after replantation of the upper extremity. Patients' reports of pain in the replanted body part were negatively correlated with the amount of cortical reorganization, i.e. the more pain the patients reported, the less reorganization of the subjects' hand representation within the primary somatosensory cortex was observed. Longitudinal studies in patients after macroreplantation are necessary to assess whether the observed reorganization in the primary somatosensory cortex is a result of changes within the representation of the replanted arm and/or neighbouring representations and to assess the relationship between the development of persistent pain and reorganization.

  1. Porous silicon reorganization: Influence on the structure, surface roughness and strain

    NASA Astrophysics Data System (ADS)

    Milenkovic, N.; Drießen, M.; Weiss, C.; Janz, S.

    2015-12-01

    Porous silicon and epitaxial thickening is a lift-off approach for silicon foil fabrication to avoid kerf losses and produce foils with thicknesses less than 50 μm. The crystal quality of the epitaxial silicon film strongly depends on the porous silicon template, which can be adapted through a reorganization process prior to epitaxy. In this work, we investigated the influence of reorganization on the structure of etched porous silicon layers. The reorganization processes were carried out in a quasi-inline Atmospheric Pressure Chemical Vapor Deposition reactor. Variations on the temperatures and process durations for the reorganization step were examined. The cross-sections showed that porous silicon requires temperatures of approximately 1150 °C to produce an excellent template for epitaxy. Atomic Force Microscopy measurements on the samples annealed at different temperatures showed the evolution of the pores from as-etched to a closed surface. These measurements confirm that the surface is not yet closed after 30 min of reorganization at 1000 °C. Different durations of the reorganization step at a fixed temperature of 1150 °C all lead to a closed surface with a comparable roughness of less than 0.5 nm. X-ray diffraction measurements show a change in the strain in the porous layer from tensile to compressive when the reorganization temperature is increased from 800 °C to 1150 °C. A longer reorganization at a fixed temperature of 1150 °C leads to a reduction in the strain without reducing the quality of the surface roughness. Defect density measurements on silicon layers deposited on those templates confirm an improvement of the template for longer reorganization times. This study shows that our porous silicon templates achieve lower surface roughness and strain values than those reported in other publications.

  2. Reorganization energy of electron transfer processes in ionic fluids: A molecular Debye-Hueckel approach

    SciTech Connect

    Xiao Tiejun; Song Xueyu

    2013-03-21

    The reorganization energy of electron transfer processes in ionic fluids is studied under the linear response approximation using a molecule Debye-Hueckel theory. Reorganization energies of some model reactants of electron transfer reactions in molten salts are obtained from molecular simulations and a molecule Debye-Hueckel approach. Good agreements between simulation results and the results from our theoretical calculations using the same model Hamiltonian are found. Applications of our theory to electron transfer reactions in room temperature ionic liquids further demonstrate that our theoretical approach presents a reliable and accurate methodology for the estimation of reorganization energies of electron transfer reactions in ionic fluids.

  3. Reorganization energy of electron transfer processes in ionic fluids: A molecular Debye-Hückel approach

    NASA Astrophysics Data System (ADS)

    Xiao, Tiejun; Song, Xueyu

    2013-03-01

    The reorganization energy of electron transfer processes in ionic fluids is studied under the linear response approximation using a molecule Debye-Hückel theory. Reorganization energies of some model reactants of electron transfer reactions in molten salts are obtained from molecular simulations and a molecule Debye-Hückel approach. Good agreements between simulation results and the results from our theoretical calculations using the same model Hamiltonian are found. Applications of our theory to electron transfer reactions in room temperature ionic liquids further demonstrate that our theoretical approach presents a reliable and accurate methodology for the estimation of reorganization energies of electron transfer reactions in ionic fluids.

  4. Reorganization energy of electron transfer processes in ionic fluids: a molecular Debye-Hückel approach.

    PubMed

    Xiao, Tiejun; Song, Xueyu

    2013-03-21

    The reorganization energy of electron transfer processes in ionic fluids is studied under the linear response approximation using a molecule Debye-Hückel theory. Reorganization energies of some model reactants of electron transfer reactions in molten salts are obtained from molecular simulations and a molecule Debye-Hückel approach. Good agreements between simulation results and the results from our theoretical calculations using the same model Hamiltonian are found. Applications of our theory to electron transfer reactions in room temperature ionic liquids further demonstrate that our theoretical approach presents a reliable and accurate methodology for the estimation of reorganization energies of electron transfer reactions in ionic fluids.

  5. Environmental impact statements. Second edition

    SciTech Connect

    Bregman, J.I.

    1999-11-01

    This book covers all the requirements for a wide variety of environmental impact statements (EISs) on the federal, state, and local levels, including a new chapter devoted to environmental justice. Topics of discussion include the following: purpose of the environment; the legal basis for environmental impact statements; the process of preparing EISs; public participation; the natural environment earth resources; the natural environment: biology; the Man-made environment: surface water, groundwater, air, noise, hazards and nuisances, historic and cultural resources, transportation, socio-economics and environmental justice.

  6. Stimulus Dependent Dynamic Reorganization of the Human Face Processing Network.

    PubMed

    Rosenthal, Gideon; Sporns, Olaf; Avidan, Galia

    2016-09-12

    Using the "face inversion effect", a hallmark of face perception, we examined network mechanisms supporting face representation by tracking functional magnetic resonance imaging (fMRI) stimulus-dependent dynamic functional connectivity within and between brain networks associated with the processing of upright and inverted faces. We developed a novel approach adapting the general linear model (GLM) framework classically used for univariate fMRI analysis to capture stimulus-dependent fMRI dynamic connectivity of the face network. We show that under the face inversion manipulation, the face and non-face networks have complementary roles that are evident in their stimulus-dependent dynamic connectivity patterns as assessed by network decomposition into components or communities. Moreover, we show that connectivity patterns are associated with the behavioral face inversion effect. Thus, we establish "a network-level signature" of the face inversion effect and demonstrate how a simple physical transformation of the face stimulus induces a dramatic functional reorganization across related brain networks. Finally, we suggest that the dynamic GLM network analysis approach, developed here for the face network, provides a general framework for modeling the dynamics of blocked stimulus-dependent connectivity experimental designs and hence can be applied to a host of neuroimaging studies.

  7. Integrated molecular mechanism directing nucleosome reorganization by human FACT.

    PubMed

    Tsunaka, Yasuo; Fujiwara, Yoshie; Oyama, Takuji; Hirose, Susumu; Morikawa, Kosuke

    2016-03-15

    Facilitates chromatin transcription (FACT) plays essential roles in chromatin remodeling during DNA transcription, replication, and repair. Our structural and biochemical studies of human FACT-histone interactions present precise views of nucleosome reorganization, conducted by the FACT-SPT16 (suppressor of Ty 16) Mid domain and its adjacent acidic AID segment. AID accesses the H2B N-terminal basic region exposed by partial unwrapping of the nucleosomal DNA, thereby triggering the invasion of FACT into the nucleosome. The crystal structure of the Mid domain complexed with an H3-H4 tetramer exhibits two separate contact sites; the Mid domain forms a novel intermolecular β structure with H4. At the other site, the Mid-H2A steric collision on the H2A-docking surface of the H3-H4 tetramer within the nucleosome induces H2A-H2B displacement. This integrated mechanism results in disrupting the H3 αN helix, which is essential for retaining the nucleosomal DNA ends, and hence facilitates DNA stripping from histone.

  8. Carbon nanotubes reorganize actin structures in cells and ex vivo.

    PubMed

    Holt, Brian D; Short, Philip A; Rape, Andrew D; Wang, Yu-li; Islam, Mohammad F; Dahl, Kris Noel

    2010-08-24

    The ability of globular actin to form filaments and higher-order network structures of the cytoskeleton is essential for cells to maintain their shape and perform essential functions such as force generation, motility, and division. Alterations of actin structures can dramatically change a cell's ability to function. We found that purified and dispersed single wall carbon nanotubes (SWCNTs) can induce actin bundling in cells and in purified model actin systems. SWCNTs do not induce acute cell death, but cell proliferation is greatly reduced in SWCNT-treated cells with an increase in actin-related division defects. Actin, normally present in basal stress fibers in control cells, is located in heterogeneous structures throughout the SWCNT-treated cell. These SWCNT-induced changes in actin structures are seen functionally in multinucleated cells and with reduced force generation. Ex vivo, purified actin filaments cross-linked with alpha-actinin and formed isotropic networks, whereas SWCNTs caused purified actin filaments to assemble into bundles. While purified, isolated SWCNTs do not appear acutely toxic, this subcellular reorganization may cause chronic changes to cellular functions.

  9. Reorganization of human motor cortex after hand replantation.

    PubMed

    Röricht, S; Machetanz, J; Irlbacher, K; Niehaus, L; Biemer, E; Meyer, B U

    2001-08-01

    In 10 patients, reorganizational changes of the motor cortex contralateral to a replanted hand (MCreplant) were studied one to 14 years after complete traumatic amputation and consecutive successful replantation of the hand. The organizational state of MCreplant was assessed for the deafferentated and peripherally deefferentated hand-associated motor cortex and the adjacent motor representation of the proximal arm. For this, response maps were established for the first dorsal interosseus and biceps brachii muscle using focal transcranial magnetic stimulation (TMS) on a skull surface grid. Characteristics of the maps were center of gravity (COG), number of effective stimulation sites, amplitude sum, and amplitudes and response threshold at the optimal stimulation point. The COG is defined by the spatial distribution of response amplitudes on the map and lies over the cortex region with the most excitable corticospinal neurones supplying the recorded muscle. The COG of the biceps map in MCreplant was shifted laterally by 9.8 +/- 3.6 mm (range 5.0-15.7 mm). The extension of the biceps map in MCreplant was increased and the responses were enlarged and had lowered thresholds. For the muscles of the replanted hand, the pattern of reorganization was different: Response amplitudes were enlarged but thresholds, COG, and area of the cortical response map were normal. The different reorganizational phenomena observed for the motor cortical areas supplying the replanted hand and the biceps brachii of the same arm may be influenced by a different extent of deafferentation and by their different role in hand motor control.

  10. The yeast genome undergoes significant topological reorganization in quiescence

    PubMed Central

    Rutledge, Mark T.; Russo, Mariano; Belton, Jon-Matthew; Dekker, Job; Broach, James R.

    2015-01-01

    We have examined the three-dimensional organization of the yeast genome during quiescence by a chromosome capture technique as a means of understanding how genome organization changes during development. For exponentially growing cells we observe high levels of inter-centromeric interaction but otherwise a predominance of intrachromosomal interactions over interchromosomal interactions, consistent with aggregation of centromeres at the spindle pole body and compartmentalization of individual chromosomes within the nucleoplasm. Three major changes occur in the organization of the quiescent cell genome. First, intrachromosomal associations increase at longer distances in quiescence as compared to growing cells. This suggests that chromosomes undergo condensation in quiescence, which we confirmed by microscopy by measurement of the intrachromosomal distances between two sites on one chromosome. This compaction in quiescence requires the condensin complex. Second, inter-centromeric interactions decrease, consistent with prior data indicating that centromeres disperse along an array of microtubules during quiescence. Third, inter-telomeric interactions significantly increase in quiescence, an observation also confirmed by direct measurement. Thus, survival during quiescence is associated with substantial topological reorganization of the genome. PMID:26202961

  11. Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation

    PubMed Central

    Sun, Liang; Pitto-Barry, Anaïs; Kirby, Nigel; Schiller, Tara L.; Sanchez, Ana M.; Dyson, M. Adam; Sloan, Jeremy; Wilson, Neil R.; O’Reilly, Rachel K.; Dove, Andrew P.

    2014-01-01

    Co-crystallization of polymers with different configurations/tacticities provides access to materials with enhanced performance. The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with each homochiral material. Herein, we report the preparation of stereocomplex micelles from a mixture of poly(L-lactide)-b-poly(acrylic acid) and poly(D-lactide)-b-poly(acrylic acid) diblock copolymers in water via crystallization-driven self-assembly. During the formation of these stereocomplex micelles, an unexpected morphological transition results in the formation of dense crystalline spherical micelles rather than cylinders. Furthermore, mixture of cylinders with opposite homochirality in either THF/H2O mixtures or in pure water at 65 °C leads to disassembly into stereocomplexed spherical micelles. Similarly, a transition is also observed in a related PEO-b-PLLA/PEO-b-PDLA system, demonstrating wider applicability. This new mechanism for morphological reorganization, through competitive crystallization and stereocomplexation and without the requirement for an external stimulus, allows for new opportunities in controlled release and delivery applications. PMID:25517544

  12. Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation

    NASA Astrophysics Data System (ADS)

    Sun, Liang; Pitto-Barry, Anaïs; Kirby, Nigel; Schiller, Tara L.; Sanchez, Ana M.; Dyson, M. Adam; Sloan, Jeremy; Wilson, Neil R.; O'Reilly, Rachel K.; Dove, Andrew P.

    2014-12-01

    Co-crystallization of polymers with different configurations/tacticities provides access to materials with enhanced performance. The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with each homochiral material. Herein, we report the preparation of stereocomplex micelles from a mixture of poly(L-lactide)-b-poly(acrylic acid) and poly(D-lactide)-b-poly(acrylic acid) diblock copolymers in water via crystallization-driven self-assembly. During the formation of these stereocomplex micelles, an unexpected morphological transition results in the formation of dense crystalline spherical micelles rather than cylinders. Furthermore, mixture of cylinders with opposite homochirality in either THF/H2O mixtures or in pure water at 65 °C leads to disassembly into stereocomplexed spherical micelles. Similarly, a transition is also observed in a related PEO-b-PLLA/PEO-b-PDLA system, demonstrating wider applicability. This new mechanism for morphological reorganization, through competitive crystallization and stereocomplexation and without the requirement for an external stimulus, allows for new opportunities in controlled release and delivery applications.

  13. Integrated molecular mechanism directing nucleosome reorganization by human FACT

    PubMed Central

    Tsunaka, Yasuo; Fujiwara, Yoshie; Oyama, Takuji; Hirose, Susumu; Morikawa, Kosuke

    2016-01-01

    Facilitates chromatin transcription (FACT) plays essential roles in chromatin remodeling during DNA transcription, replication, and repair. Our structural and biochemical studies of human FACT–histone interactions present precise views of nucleosome reorganization, conducted by the FACT-SPT16 (suppressor of Ty 16) Mid domain and its adjacent acidic AID segment. AID accesses the H2B N-terminal basic region exposed by partial unwrapping of the nucleosomal DNA, thereby triggering the invasion of FACT into the nucleosome. The crystal structure of the Mid domain complexed with an H3–H4 tetramer exhibits two separate contact sites; the Mid domain forms a novel intermolecular β structure with H4. At the other site, the Mid–H2A steric collision on the H2A-docking surface of the H3–H4 tetramer within the nucleosome induces H2A–H2B displacement. This integrated mechanism results in disrupting the H3 αN helix, which is essential for retaining the nucleosomal DNA ends, and hence facilitates DNA stripping from histone. PMID:26966247

  14. Hippocampal-neocortical functional reorganization underlies children's cognitive development.

    PubMed

    Qin, Shaozheng; Cho, Soohyun; Chen, Tianwen; Rosenberg-Lee, Miriam; Geary, David C; Menon, Vinod

    2014-09-01

    The importance of the hippocampal system for rapid learning and memory is well recognized, but its contributions to a cardinal feature of children's cognitive development-the transition from procedure-based to memory-based problem-solving strategies-are unknown. Here we show that the hippocampal system is pivotal to this strategic transition. Longitudinal functional magnetic resonance imaging (fMRI) in 7-9-year-old children revealed that the transition from use of counting to memory-based retrieval parallels increased hippocampal and decreased prefrontal-parietal engagement during arithmetic problem solving. Longitudinal improvements in retrieval-strategy use were predicted by increased hippocampal-neocortical functional connectivity. Beyond childhood, retrieval-strategy use continued to improve through adolescence into adulthood and was associated with decreased activation but more stable interproblem representations in the hippocampus. Our findings provide insights into the dynamic role of the hippocampus in the maturation of memory-based problem solving and establish a critical link between hippocampal-neocortical reorganization and children's cognitive development.

  15. Increased spatial variance accompanies reorganization of two continental shelf ecosystems.

    PubMed

    Litzow, Michael A; Urban, J Daniel; Laurel, Benjamin J

    2008-09-01

    Phase transitions between alternate stable states in marine ecosystems lead to disruptive changes in ecosystem services, especially fisheries productivity. We used trawl survey data spanning phase transitions in the North Pacific (Gulf of Alaska) and the North Atlantic (Scotian Shelf) to test for increases in ecosystem variability that might provide early warning of such transitions. In both time series, elevated spatial variability in a measure of community composition (ratio of cod [Gadus sp.] abundance to prey abundance) accompanied transitions between ecosystem states, and variability was negatively correlated with distance from the ecosystem transition point. In the Gulf of Alaska, where the phase transition was apparently the result of a sudden perturbation (climate regime shift), variance increased one year before the transition in mean state occurred. On the Scotian Shelf, where ecosystem reorganization was the result of persistent overfishing, a significant increase in variance occurred three years before the transition in mean state was detected. However, we could not reject the alternate explanation that increased variance may also have simply been inherent to the final stable state in that ecosystem. Increased variance has been previously observed around transition points in models, but rarely in real ecosystems, and our results demonstrate the possible management value in tracking the variance of key parameters in exploited ecosystems.

  16. Light signaling controls nuclear architecture reorganization during seedling establishment.

    PubMed

    Bourbousse, Clara; Mestiri, Imen; Zabulon, Gerald; Bourge, Mickaël; Formiggini, Fabio; Koini, Maria A; Brown, Spencer C; Fransz, Paul; Bowler, Chris; Barneche, Fredy

    2015-05-26

    The spatial organization of chromatin can be subject to extensive remodeling in plant somatic cells in response to developmental and environmental signals. However, the mechanisms controlling these dynamic changes and their functional impact on nuclear activity are poorly understood. Here, we determined that light perception triggers a switch between two different nuclear architectural schemes during Arabidopsis postembryonic development. Whereas progressive nucleus expansion and heterochromatin rearrangements in cotyledon cells are achieved similarly under light and dark conditions during germination, the later steps that lead to mature nuclear phenotypes are intimately associated with the photomorphogenic transition in an organ-specific manner. The light signaling integrators DE-ETIOLATED 1 and CONSTITUTIVE PHOTOMORPHOGENIC 1 maintain heterochromatin in a decondensed state in etiolated cotyledons. In contrast, under light conditions cryptochrome-mediated photoperception releases nuclear expansion and heterochromatin compaction within conspicuous chromocenters. For all tested loci, chromatin condensation during photomorphogenesis does not detectably rely on DNA methylation-based processes. Notwithstanding, the efficiency of transcriptional gene silencing may be impacted during the transition, as based on the reactivation of transposable element-driven reporter genes. Finally, we report that global engagement of RNA polymerase II in transcription is highly increased under light conditions, suggesting that cotyledon photomorphogenesis involves a transition from globally quiescent to more active transcriptional states. Given these findings, we propose that light-triggered changes in nuclear architecture underlie interplays between heterochromatin reorganization and transcriptional reprogramming associated with the establishment of photosynthesis.

  17. Disulfide bridge reorganization induced by proline mutations in maurotoxin.

    PubMed

    Carlier, E; Fajloun, Z; Mansuelle, P; Fathallah, M; Mosbah, A; Oughideni, R; Sandoz, G; Di Luccio, E; Geib, S; Regaya, I; Brocard, J; Rochat, H; Darbon, H; Devaux, C; Sabatier, J M; de Waard, M

    2001-02-02

    Maurotoxin (MTX) is a 34-residue toxin that has been isolated from the venom of the chactidae scorpion Scorpio maurus palmatus, and characterized. Together with Pi1 and HsTx1, MTX belongs to a family of short-chain four-disulfide-bridged scorpion toxins acting on potassium channels. However, contrary to other members of this family, MTX exhibits an uncommon disulfide bridge organization of the type C1-C5, C2-C6, C3-C4 and C7-C8, versus C1-C5, C2-C6, C3-C7 and C4-C8 for both Pi1 and HsTx1. Here, we report that the substitution of MTX proline residues located at positions 12 and/or 20, adjacent to C3 (Cys(13)) and C4 (Cys(19)), results in conventional Pi1- and HsTx1-like arrangement of the half-cystine pairings. In this case, this novel disulfide bridge arrangement is without obvious incidence on the overall three-dimensional structure of the toxin. Pharmacological assays of this structural analog, [A(12),A(20)]MTX, reveal that the blocking activities on Shaker B and rat Kv1.2 channels remain potent whereas the peptide becomes inactive on rat Kv1.3. These data indicate, for the first time, that discrete point mutations in MTX can result in a marked reorganization of the half-cystine pairings, accompanied with a novel pharmacological profile for the analog.

  18. Membrane indentation triggers clathrin lattice reorganization and fluidization.

    PubMed

    Cordella, Nicholas; Lampo, Thomas J; Melosh, Nicholas; Spakowitz, Andrew J

    2015-01-21

    Clathrin-mediated endocytosis involves the coordinated assembly of clathrin cages around membrane indentations, necessitating fluid-like reorganization followed by solid-like stabilization. This apparent duality in clathrin's in vivo behavior provides some indication that the physical interactions between clathrin triskelia and the membrane effect a local response that triggers fluid-solid transformations within the clathrin lattice. We develop a computational model to study the response of clathrin protein lattices to spherical deformations of the underlying flexible membrane. These deformations are similar to the shapes assumed during intracellular trafficking of nanoparticles. Through Monte Carlo simulations of clathrin-on-membrane systems, we observe that these membrane indentations give rise to a greater than normal defect density within the overlaid clathrin lattice. In many cases, the bulk surrounding lattice remains in a crystalline phase, and the extra defects are localized to the regions of large curvature. This can be explained by the fact that the in-plane elastic stress in the clathrin lattice are reduced by coupling defects to highly curved regions. The presence of defects brought about by indentation can result in the fluidization of a lattice that would otherwise be crystalline, resulting in an indentation-driven, defect-mediated phase transition. Altering subunit elasticity or membrane properties is shown to drive a similar transition, and we present phase diagrams that map out the combined effects of these parameters on clathrin lattice properties.

  19. Global reorganization of the nuclear landscape in senescent cells.

    PubMed

    Chandra, Tamir; Ewels, Philip Andrew; Schoenfelder, Stefan; Furlan-Magaril, Mayra; Wingett, Steven William; Kirschner, Kristina; Thuret, Jean-Yves; Andrews, Simon; Fraser, Peter; Reik, Wolf

    2015-02-03

    Cellular senescence has been implicated in tumor suppression, development, and aging and is accompanied by large-scale chromatin rearrangements, forming senescence-associated heterochromatic foci (SAHF). However, how the chromatin is reorganized during SAHF formation is poorly understood. Furthermore, heterochromatin formation in senescence appears to contrast with loss of heterochromatin in Hutchinson-Gilford progeria. We mapped architectural changes in genome organization in cellular senescence using Hi-C. Unexpectedly, we find a dramatic sequence- and lamin-dependent loss of local interactions in heterochromatin. This change in local connectivity resolves the paradox of opposing chromatin changes in senescence and progeria. In addition, we observe a senescence-specific spatial clustering of heterochromatic regions, suggesting a unique second step required for SAHF formation. Comparison of embryonic stem cells (ESCs), somatic cells, and senescent cells shows a unidirectional loss in local chromatin connectivity, suggesting that senescence is an endpoint of the continuous nuclear remodelling process during differentiation. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  20. Reorganization of the North Atlantic Oscillation during early Holocene deglaciation

    NASA Astrophysics Data System (ADS)

    Wassenburg, Jasper A.; Dietrich, Stephan; Fietzke, Jan; Fohlmeister, Jens; Jochum, Klaus Peter; Scholz, Denis; Richter, Detlev K.; Sabaoui, Abdellah; Spötl, Christoph; Lohmann, Gerrit; Andreae, Meinrat O.; Immenhauser, Adrian

    2016-08-01

    The North Atlantic Oscillation is the dominant atmospheric pressure mode in the North Atlantic region and affects winter temperature and precipitation in the Mediterranean, northwest Europe, Greenland, and Asia. The index that describes the sea-level pressure difference between Iceland and the Azores is correlated with a dipole precipitation pattern over northwest Europe and northwest Africa. How the North Atlantic Oscillation will develop as the Greenland ice sheet melts is unclear. A potential past analogue is the early Holocene, during which melting ice sheets around the North Atlantic freshened surface waters, affecting the strength of the meridional overturning circulation. Here we present a Holocene rainfall record from northwest Africa based on speleothem δ18O and compare it against a speleothem-based rainfall record from Europe. The two records are positively correlated during the early Holocene, followed by a shift to an anti-correlation, similar to the modern record, during the mid-Holocene. On the basis of our simulations with an Earth system model, we suggest the shift to the anti-correlation reflects a large-scale atmospheric and oceanic reorganization in response to the demise of the Laurentide ice sheet and a strong reduction of meltwater flux to the North Atlantic, pointing to a potential sensitivity of the North Atlantic Oscillation to the melting of ice sheets.

  1. Global Reorganization of the Nuclear Landscape in Senescent Cells

    PubMed Central

    Chandra, Tamir; Ewels, Philip Andrew; Schoenfelder, Stefan; Furlan-Magaril, Mayra; Wingett, Steven William; Kirschner, Kristina; Thuret, Jean-Yves; Andrews, Simon; Fraser, Peter; Reik, Wolf

    2015-01-01

    Summary Cellular senescence has been implicated in tumor suppression, development, and aging and is accompanied by large-scale chromatin rearrangements, forming senescence-associated heterochromatic foci (SAHF). However, how the chromatin is reorganized during SAHF formation is poorly understood. Furthermore, heterochromatin formation in senescence appears to contrast with loss of heterochromatin in Hutchinson-Gilford progeria. We mapped architectural changes in genome organization in cellular senescence using Hi-C. Unexpectedly, we find a dramatic sequence- and lamin-dependent loss of local interactions in heterochromatin. This change in local connectivity resolves the paradox of opposing chromatin changes in senescence and progeria. In addition, we observe a senescence-specific spatial clustering of heterochromatic regions, suggesting a unique second step required for SAHF formation. Comparison of embryonic stem cells (ESCs), somatic cells, and senescent cells shows a unidirectional loss in local chromatin connectivity, suggesting that senescence is an endpoint of the continuous nuclear remodelling process during differentiation. PMID:25640177

  2. Cytoskeletal Reorganization Drives Mesenchymal Condensation and Regulates Downstream Molecular Signaling

    PubMed Central

    Ray, Poulomi; Chapman, Susan C.

    2015-01-01

    Skeletal condensation occurs when specified mesenchyme cells self-organize over several days to form a distinctive cartilage template. Here, we determine how and when specified mesenchyme cells integrate mechanical and molecular information from their environment, forming cartilage condensations in the pharyngeal arches of chick embryos. By disrupting cytoskeletal reorganization, we demonstrate that dynamic cell shape changes drive condensation and modulate the response of the condensing cells to Fibroblast Growth Factor (FGF), Bone Morphogenetic Protein (BMP) and Transforming Growth Factor beta (TGF-β) signaling pathways. Rho Kinase (ROCK)-driven actomyosin contractions and Myosin II-generated differential cell cortex tension regulate these cell shape changes. Disruption of the condensation process inhibits the differentiation of the mesenchyme cells into chondrocytes, demonstrating that condensation regulates the fate of the mesenchyme cells. We also find that dorsal and ventral condensations undergo distinct cell shape changes. BMP signaling is instructive for dorsal condensation-specific cell shape changes. Moreover, condensations exhibit ventral characteristics in the absence of BMP signaling, suggesting that in the pharyngeal arches ventral morphology is the ground pattern. Overall, this study characterizes the interplay between cytoskeletal dynamics and molecular signaling in a self-organizing system during tissue morphogenesis. PMID:26237312

  3. Behavioral Consequences and Cortical Reorganization in Homonymous Hemianopia

    PubMed Central

    Chokron, Sylvie; Perez, Céline; Peyrin, Carole

    2016-01-01

    The most common visual defect to follow a lesion of the retrochiasmal pathways is homonymous hemianopia (HH), whereby, in each eye, patients are blind to the contralesional visual field. From a behavioral perspective, in addition to exhibiting a severe deficit in their contralesional visual field, hemianopic patients can also present implicit residual capacities, now usually referred to collectively as blindsight. It was recently demonstrated that HH patients can also suffer from a subtle deficit in their ipsilesional visual field, called sightblindness (the reverse case of blindsight). Furthermore, the nature of the visual deficit in the contralesional and ipsilesional visual fields, as well as the pattern of functional reorganization in the occipital lobe of HH patients after stroke, all appear to depend on the lesion side. In addition to their contralesional and ipsilesional visual deficits, and to their residual capacities, HH patients can also experience visual hallucinations in their blind field, the physiopathological mechanisms of which remain poorly understood. Herein we review blindsight in terms of its better-known aspects as well as its less-studied clinical signs such as sightblindness, hemispheric specialization and visual hallucinations. We also discuss the implications of recent experimental findings for rehabilitation of visual field defects in hemianopic patients. PMID:27445717

  4. Supervillin Reorganizes the Actin Cytoskeleton and Increases Invadopodial Efficiency

    PubMed Central

    Crowley, Jessica L.; Smith, Tara C.; Fang, Zhiyou; Takizawa, Norio

    2009-01-01

    Tumor cells use actin-rich protrusions called invadopodia to degrade extracellular matrix (ECM) and invade tissues; related structures, termed podosomes, are sites of dynamic ECM interaction. We show here that supervillin (SV), a peripheral membrane protein that binds F-actin and myosin II, reorganizes the actin cytoskeleton and potentiates invadopodial function. Overexpressed SV induces redistribution of lamellipodial cortactin and lamellipodin/RAPH1/PREL1 away from the cell periphery to internal sites and concomitantly increases the numbers of F-actin punctae. Most punctae are highly dynamic and colocalize with the podosome/invadopodial proteins, cortactin, Tks5, and cdc42. Cortactin binds SV sequences in vitro and contributes to the formation of enhanced green fluorescent protein (EGFP)-SV induced punctae. SV localizes to the cores of Src-generated podosomes in COS-7 cells and with invadopodia in MDA-MB-231 cells. EGFP-SV overexpression increases average numbers of ECM holes per cell; RNA interference-mediated knockdown of SV decreases these numbers. Although SV knockdown alone has no effect, simultaneous down-regulation of SV and the closely related protein gelsolin reduces invasion through ECM. Together, our results show that SV is a component of podosomes and invadopodia and that SV plays a role in invadopodial function, perhaps as a mediator of cortactin localization, activation state, and/or dynamics of metalloproteinases at the ventral cell surface. PMID:19109420

  5. Intermediate filament reorganization dynamically influences cancer cell alignment and migration

    PubMed Central

    Holle, Andrew W.; Kalafat, Melih; Ramos, Adria Sales; Seufferlein, Thomas; Kemkemer, Ralf; Spatz, Joachim P.

    2017-01-01

    The interactions between a cancer cell and its extracellular matrix (ECM) have been the focus of an increasing amount of investigation. The role of the intermediate filament keratin in cancer has also been coming into focus of late, but more research is needed to understand how this piece fits in the puzzle of cytoskeleton-mediated invasion and metastasis. In Panc-1 invasive pancreatic cancer cells, keratin phosphorylation in conjunction with actin inhibition was found to be sufficient to reduce cell area below either treatment alone. We then analyzed intersecting keratin and actin fibers in the cytoskeleton of cyclically stretched cells and found no directional correlation. The role of keratin organization in Panc-1 cellular morphological adaptation and directed migration was then analyzed by culturing cells on cyclically stretched polydimethylsiloxane (PDMS) substrates, nanoscale grates, and rigid pillars. In general, the reorganization of the keratin cytoskeleton allows the cell to become more ‘mobile’- exhibiting faster and more directed migration and orientation in response to external stimuli. By combining keratin network perturbation with a variety of physical ECM signals, we demonstrate the interconnected nature of the architecture inside the cell and the scaffolding outside of it, and highlight the key elements facilitating cancer cell-ECM interactions. PMID:28338091

  6. Light signaling controls nuclear architecture reorganization during seedling establishment

    PubMed Central

    Bourbousse, Clara; Mestiri, Imen; Zabulon, Gerald; Bourge, Mickaël; Formiggini, Fabio; Koini, Maria A.; Brown, Spencer C.; Fransz, Paul; Bowler, Chris; Barneche, Fredy

    2015-01-01

    The spatial organization of chromatin can be subject to extensive remodeling in plant somatic cells in response to developmental and environmental signals. However, the mechanisms controlling these dynamic changes and their functional impact on nuclear activity are poorly understood. Here, we determined that light perception triggers a switch between two different nuclear architectural schemes during Arabidopsis postembryonic development. Whereas progressive nucleus expansion and heterochromatin rearrangements in cotyledon cells are achieved similarly under light and dark conditions during germination, the later steps that lead to mature nuclear phenotypes are intimately associated with the photomorphogenic transition in an organ-specific manner. The light signaling integrators DE-ETIOLATED 1 and CONSTITUTIVE PHOTOMORPHOGENIC 1 maintain heterochromatin in a decondensed state in etiolated cotyledons. In contrast, under light conditions cryptochrome-mediated photoperception releases nuclear expansion and heterochromatin compaction within conspicuous chromocenters. For all tested loci, chromatin condensation during photomorphogenesis does not detectably rely on DNA methylation-based processes. Notwithstanding, the efficiency of transcriptional gene silencing may be impacted during the transition, as based on the reactivation of transposable element-driven reporter genes. Finally, we report that global engagement of RNA polymerase II in transcription is highly increased under light conditions, suggesting that cotyledon photomorphogenesis involves a transition from globally quiescent to more active transcriptional states. Given these findings, we propose that light-triggered changes in nuclear architecture underlie interplays between heterochromatin reorganization and transcriptional reprogramming associated with the establishment of photosynthesis. PMID:25964332

  7. Enhancing Physical Activity and Brain Reorganization after Stroke

    PubMed Central

    Carr, Janet H.; Shepherd, Roberta B.

    2011-01-01

    It is becoming increasingly clear that, if reorganization of brain function is to be optimal after stroke, there needs to be a reorganisation of the methods used in physical rehabilitation and the time spent in specific task practice, strength and endurance training, and aerobic exercise. Frequency and intensity of rehabilitation need to be increased so that patients can gain the energy levels and vigour necessary for participation in physical activity both during rehabilitation and after discharge. It is evident that many patients are discharged from inpatient rehabilitation severely deconditioned, meaning that their energy levels are too low for active participation in daily life. Physicians, therapists, and nursing staff responsible for rehabilitation practice should address this issue not only during inpatient rehabilitation but also after discharge by promoting and supporting community-based exercise opportunities. During inpatient rehabilitation, group sessions should be frequent and need to include specific aerobic training. Physiotherapy must take advantage of the training aids available, including exercise equipment such as treadmills, and of new developments in computerised feedback systems, robotics, and electromechanical trainers. For illustrative purposes, this paper focuses on the role of physiotherapists, but the necessary changes in practice and in attitude will require cooperation from many others. PMID:21766024

  8. Reorganization of the brain and heart rhythm during autogenic meditation.

    PubMed

    Kim, Dae-Keun; Rhee, Jyoo-Hi; Kang, Seung Wan

    2014-01-13

    The underlying changes in heart coherence that are associated with reported EEG changes in response to meditation have been explored. We measured EEG and heart rate variability (HRV) before and during autogenic meditation. Fourteen subjects participated in the study. Heart coherence scores were significantly increased during meditation compared to the baseline. We found near significant decrease in high beta absolute power, increase in alpha relative power and significant increases in lower (alpha) and higher (above beta) band coherence during 3~min epochs of heart coherent meditation compared to 3~min epochs of heart non-coherence at baseline. The coherence and relative power increase in alpha band and absolute power decrease in high beta band could reflect relaxation state during the heart coherent meditation. The coherence increase in the higher (above beta) band could reflect cortico-cortical local integration and thereby affect cognitive reorganization, simultaneously with relaxation. Further research is still needed for a confirmation of heart coherence as a simple window for the meditative state.

  9. Hippocampal-neocortical functional reorganization underlies children's cognitive development

    PubMed Central

    Qin, Shaozheng; Cho, Soohyun; Chen, Tianwen; Rosenberg-Lee, Miriam; Geary, David C.; Menon, Vinod

    2014-01-01

    The importance of the hippocampal system for rapid learning and memory is well recognized, but its contributions to a cardinal feature of children's cognitive development – the transition from procedure-based to memory-based problem solving strategies – are unknown. Here we show that the hippocampal system is pivotal to this strategic transition. Longitudinal fMRI in children, ages 7 to 9, revealed that the transition from use of counting to memory-based retrieval parallels increased hippocampal and decreased prefrontal-parietal engagement during arithmetic problem solving. Critically, longitudinal improvements in retrieval strategy use were predicted by increased hippocampal-neocortical functional connectivity. Beyond childhood, retrieval strategy use continued to improve through adolescence into adulthood, and was associated with decreased activation but more stable inter-problem representations in the hippocampus. Our findings provide novel insights into the dynamic role of the hippocampus in the maturation of memory-based problem solving, and establish a critical link between hippocampal-neocortical reorganization and children's cognitive development. PMID:25129076

  10. An improved algorithm of fiber tractography demonstrates postischemic cerebral reorganization

    NASA Astrophysics Data System (ADS)

    Liu, Xiao-dong; Lu, Jie; Yao, Li; Li, Kun-cheng; Zhao, Xiao-jie

    2008-03-01

    In vivo white matter tractography by diffusion tensor imaging (DTI) accurately represents the organizational architecture of white matter in the vicinity of brain lesions and especially ischemic brain. In this study, we suggested an improved fiber tracking algorithm based on TEND, called TENDAS, for tensor deflection with adaptive stepping, which had been introduced a stepping framework for interpreting the algorithm behavior as a function of the tensor shape (linear-shaped or not) and tract history. The propagation direction at each step was given by the deflection vector. TENDAS tractography was used to examine a 17-year-old recovery patient with congenital right hemisphere artery stenosis combining with fMRI. Meaningless picture location was used as spatial working memory task in this study. We detected the shifted functional localization to the contralateral homotypic cortex and more prominent and extensive left-sided parietal and medial frontal cortical activations which were used directly as seed mask for tractography for the reconstruction of individual spatial parietal pathways. Comparing with the TEND algorithms, TENDAS shows smoother and less sharp bending characterization of white matter architecture of the parietal cortex. The results of this preliminary study were twofold. First, TENDAS may provide more adaptability and accuracy in reconstructing certain anatomical features, whereas it is very difficult to verify tractography maps of white matter connectivity in the living human brain. Second, our study indicates that combination of TENDAS and fMRI provide a unique image of functional cortical reorganization and structural modifications of postischemic spatial working memory.

  11. Mechanism of filopodia initiation by reorganization of a dendritic network

    PubMed Central

    Svitkina, Tatyana M.; Bulanova, Elena A.; Chaga, Oleg Y.; Vignjevic, Danijela M.; Kojima, Shin-ichiro; Vasiliev, Jury M.; Borisy, Gary G.

    2003-01-01

    Afilopodium protrudes by elongation of bundled actin filaments in its core. However, the mechanism of filopodia initiation remains unknown. Using live-cell imaging with GFP-tagged proteins and correlative electron microscopy, we performed a kinetic-structural analysis of filopodial initiation in B16F1 melanoma cells. Filopodial bundles arose not by a specific nucleation event, but by reorganization of the lamellipodial dendritic network analogous to fusion of established filopodia but occurring at the level of individual filaments. Subsets of independently nucleated lamellipodial filaments elongated and gradually associated with each other at their barbed ends, leading to formation of cone-shaped structures that we term Λ-precursors. An early marker of initiation was the gradual coalescence of GFP-vasodilator-stimulated phosphoprotein (GFP-VASP) fluorescence at the leading edge into discrete foci. The GFP-VASP foci were associated with Λ-precursors, whereas Arp2/3 was not. Subsequent recruitment of fascin to the clustered barbed ends of Λ-precursors initiated filament bundling and completed formation of the nascent filopodium. We propose a convergent elongation model of filopodia initiation, stipulating that filaments within the lamellipodial dendritic network acquire privileged status by binding a set of molecules (including VASP) to their barbed ends, which protect them from capping and mediate association of barbed ends with each other. PMID:12566431

  12. Mechanism of filopodia initiation by reorganization of a dendritic network.

    PubMed

    Svitkina, Tatyana M; Bulanova, Elena A; Chaga, Oleg Y; Vignjevic, Danijela M; Kojima, Shin-ichiro; Vasiliev, Jury M; Borisy, Gary G

    2003-02-03

    Afilopodium protrudes by elongation of bundled actin filaments in its core. However, the mechanism of filopodia initiation remains unknown. Using live-cell imaging with GFP-tagged proteins and correlative electron microscopy, we performed a kinetic-structural analysis of filopodial initiation in B16F1 melanoma cells. Filopodial bundles arose not by a specific nucleation event, but by reorganization of the lamellipodial dendritic network analogous to fusion of established filopodia but occurring at the level of individual filaments. Subsets of independently nucleated lamellipodial filaments elongated and gradually associated with each other at their barbed ends, leading to formation of cone-shaped structures that we term Lambda-precursors. An early marker of initiation was the gradual coalescence of GFP-vasodilator-stimulated phosphoprotein (GFP-VASP) fluorescence at the leading edge into discrete foci. The GFP-VASP foci were associated with Lambda-precursors, whereas Arp2/3 was not. Subsequent recruitment of fascin to the clustered barbed ends of Lambda-precursors initiated filament bundling and completed formation of the nascent filopodium. We propose a convergent elongation model of filopodia initiation, stipulating that filaments within the lamellipodial dendritic network acquire privileged status by binding a set of molecules (including VASP) to their barbed ends, which protect them from capping and mediate association of barbed ends with each other.

  13. Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome

    PubMed Central

    MacMillan, Heath A.; Knee, Jose M.; Dennis, Alice B.; Udaka, Hiroko; Marshall, Katie E.; Merritt, Thomas J. S.; Sinclair, Brent J.

    2016-01-01

    Cold tolerance is a key determinant of insect distribution and abundance, and thermal acclimation can strongly influence organismal stress tolerance phenotypes, particularly in small ectotherms like Drosophila. However, there is limited understanding of the molecular and biochemical mechanisms that confer such impressive plasticity. Here, we use high-throughput mRNA sequencing (RNA-seq) and liquid chromatography – mass spectrometry (LC-MS) to compare the transcriptomes and metabolomes of D. melanogaster acclimated as adults to warm (rearing) (21.5 °C) or cold conditions (6 °C). Cold acclimation improved cold tolerance and led to extensive biological reorganization: almost one third of the transcriptome and nearly half of the metabolome were differentially regulated. There was overlap in the metabolic pathways identified via transcriptomics and metabolomics, with proline and glutathione metabolism being the most strongly-supported metabolic pathways associated with increased cold tolerance. We discuss several new targets in the study of insect cold tolerance (e.g. dopamine signaling and Na+-driven transport), but many previously identified candidate genes and pathways (e.g. heat shock proteins, Ca2+ signaling, and ROS detoxification) were also identified in the present study, and our results are thus consistent with and extend the current understanding of the mechanisms of insect chilling tolerance. PMID:27357258

  14. Local awakening: regional reorganizations of brain oscillations after sleep.

    PubMed

    Tsai, Pei-Jung; Chen, Sharon Chia-Ju; Hsu, Chun-Yao; Wu, Changwei W; Wu, Yu-Chin; Hung, Ching-Sui; Yang, Albert C; Liu, Po-Yu; Biswal, Bharat; Lin, Ching-Po

    2014-11-15

    Brain functions express rhythmic fluctuations accompanied by sleep and wakefulness each day, but how sleep regulates brain rhythms remains unclear. Following the dose-dependent local sleep concept, two succeeding questions emerge: (1) is the sleep regulation a network-specific process; and (2) is the awakening state dependent on the previous sleep stages? To answer the questions, we conducted simultaneous EEG and fMRI recordings over 22 healthy male participants, along pre-sleep, nocturnal sleep and awakening. Using paired comparisons between awakening and pre-sleep conditions, three scenarios of the regional specificity were demonstrated on awakening: (1) the default-mode and hippocampal networks maintained similar connectivity and spectral power; (2) the sensorimotor network presented reduced connectivity and spectral power; and (3) the thalamus demonstrated substantially enhanced connectivity to the neo-cortex with decreased spectral power. With regard to the stage effect, the deep sleep group had significant changes in both functional connectivity and spectral power on awakening, whereas the indices of light sleep group remained relatively quiescent after sleep. The phenomena implied that slow-wave sleep could be key to rebooting the BOLD fluctuations after sleep. In conclusion, the regional specificity and the stage effect were verified in support of the local awakening concept, indicating that sleep regulation leads to the reorganization of brain networks upon awakening.

  15. Sleep after spatial learning promotes covert reorganization of brain activity.

    PubMed

    Orban, Pierre; Rauchs, Géraldine; Balteau, Evelyne; Degueldre, Christian; Luxen, André; Maquet, Pierre; Peigneux, Philippe

    2006-05-02

    Sleep promotes the integration of recently acquired spatial memories into cerebral networks for the long term. In this study, we examined how sleep deprivation hinders this consolidation process. Using functional MRI, we mapped regional cerebral activity during place-finding navigation in a virtual town, immediately after learning and 3 days later, in subjects either allowed regular sleep (RS) or totally sleep-deprived (TSD) on the first posttraining night. At immediate and delayed retrieval, place-finding navigation elicited increased brain activity in an extended hippocampo-neocortical network in both RS and TSD subjects. Behavioral performance was equivalent between groups. However, striatal navigation-related activity increased more at delayed retrieval in RS than in TSD subjects. Furthermore, correlations between striatal response and behavioral performance, as well as functional connectivity between the striatum and the hippocampus, were modulated by posttraining sleep. These data suggest that brain activity is restructured during sleep in such a way that navigation in the virtual environment, initially related to a hippocampus-dependent spatial strategy, becomes progressively contingent in part on a response-based strategy mediated by the striatum. Both neural strategies eventually relate to equivalent performance levels, indicating that covert reorganization of brain patterns underlying navigation after sleep is not necessarily accompanied by overt changes in behavior.

  16. Cytoskeletal Reorganization Drives Mesenchymal Condensation and Regulates Downstream Molecular Signaling.

    PubMed

    Ray, Poulomi; Chapman, Susan C

    2015-01-01

    Skeletal condensation occurs when specified mesenchyme cells self-organize over several days to form a distinctive cartilage template. Here, we determine how and when specified mesenchyme cells integrate mechanical and molecular information from their environment, forming cartilage condensations in the pharyngeal arches of chick embryos. By disrupting cytoskeletal reorganization, we demonstrate that dynamic cell shape changes drive condensation and modulate the response of the condensing cells to Fibroblast Growth Factor (FGF), Bone Morphogenetic Protein (BMP) and Transforming Growth Factor beta (TGF-β) signaling pathways. Rho Kinase (ROCK)-driven actomyosin contractions and Myosin II-generated differential cell cortex tension regulate these cell shape changes. Disruption of the condensation process inhibits the differentiation of the mesenchyme cells into chondrocytes, demonstrating that condensation regulates the fate of the mesenchyme cells. We also find that dorsal and ventral condensations undergo distinct cell shape changes. BMP signaling is instructive for dorsal condensation-specific cell shape changes. Moreover, condensations exhibit ventral characteristics in the absence of BMP signaling, suggesting that in the pharyngeal arches ventral morphology is the ground pattern. Overall, this study characterizes the interplay between cytoskeletal dynamics and molecular signaling in a self-organizing system during tissue morphogenesis.

  17. Hospital activity and cost incurred because of unregistered patients in England: considerations for current and new commissioners.

    PubMed

    Davies, A R; Chitnis, X; Bardsley, M

    2013-12-01

    Commissioners are responsible for providing health care for defined geographical areas. A lack of comprehensive national and local information on health needs of unregistered populations makes health service planning difficult. A cross-sectional study using Hospital Episode Statistics to quantify the level of inpatient and outpatient activity, and associated cost by patients not registered in primary care in English NHS hospitals. Unregistered patients were defined as those without a valid GP registration, prisoners, military personnel, asylum seekers/immigrants and the homeless. Unregistered patients accounted for 99 615 inpatient admissions and 370 504 outpatient attendances in 2009/10, at a total cost of £242 m. Mental health accounted for 30% of all inpatient costs. The majority of unregistered patients were male and aged 20-39 years. There were high levels of activity and cost in urban local authorities (LAs) (Birmingham and London) and LAs with links to military services (Salisbury, Richmondshire, Southampton). A high total inpatient cost was attributed to trauma, general medicine and mental health specialties. A high total outpatient cost was attributed to genitourinary medicine and trauma specialties. Health care use by unregistered populations is an important consideration for resource allocation and planning health care services at national and local levels.

  18. Revocation of tax-exempt status, excise taxes, and other intermediate sanctions issues, plus income taxes: how the rules have changed after Caracci v. Commissioner.

    PubMed

    King, James R; Boyce, David S

    2003-01-01

    This Article discusses Caracci v. Commissioner, in which the Tax Court imposed intermediate sanctions based on its finding that insiders caused three applicable tax-exempt organizations to sell assets to three for-profit entities owned and controlled by those same insiders. It explores the standards enumerated in Caracci, hypothesizes as to the pending appeal, and examines the guidance given by the decision's clarification of the intermediate sanctions provisions of the Internal Revenue Code.

  19. 76 FR 63957 - Consumer Product Policy Statement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-14

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Consumer Product Policy Statement AGENCY: Nuclear Regulatory Commission. ACTION: Proposed revision to policy statement; request for public comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC...

  20. The Impact Statement--Part II

    ERIC Educational Resources Information Center

    Peterson, Russell W.

    1976-01-01

    Discusses criticism of the Environmental Impact Statements now required for any proposed action by a federal agency. Stresses the advantages of using these statements, and how their quality standards can be raised. (MLH)

  1. 29 CFR 24.114 - District court jurisdiction of retaliation complaints under the Energy Reorganization Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ENVIRONMENTAL STATUTES AND SECTION 211 OF THE ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Miscellaneous... faith of the complainant, the complainant may bring an action at law or equity for de novo review in...

  2. 29 CFR 24.114 - District court jurisdiction of retaliation complaints under the Energy Reorganization Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ENVIRONMENTAL STATUTES AND SECTION 211 OF THE ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Miscellaneous... faith of the complainant, the complainant may bring an action at law or equity for de novo review in...

  3. 29 CFR 24.114 - District court jurisdiction of retaliation complaints under the Energy Reorganization Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ENVIRONMENTAL STATUTES AND SECTION 211 OF THE ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Miscellaneous... faith of the complainant, the complainant may bring an action at law or equity for de novo review in...

  4. Accounting Principles and Financial Statements.

    ERIC Educational Resources Information Center

    Robinson, Daniel D.

    1973-01-01

    This document presents the background and analysis of the American Institute of Certified Public Accountants (AICPA) guide to auditing colleges and universities. Highlights include the approval of the market value option, the treatment of endowment gains, debt services as transfers, the decisions on pledges, the use of financial statements, the…

  5. Consensus Statement Immunonutrition and Exercise.

    PubMed

    Bermon, Stephane; Castell, Lindy M; Calder, Philip C; Bishop, Nicolette C; Blomstrand, Eva; Mooren, Frank C; Krüger, Karsten; Kavazis, Andreas N; Quindry, John C; Senchina, David S; Nieman, David C; Gleeson, Michael; Pyne, David B; Kitic, Cecilia M; Close, Graeme L; Larson-Meyer, D Enette; Marcos, Ascension; Meydani, Simin N; Walsh, Neil P; Nagatomi, Ryochi

    2017-01-01

    In this consensus statement on immunonutrition and exercise, a panel of knowledgeable contributors from across the globe provides a consensus of updated science, including the background, the aspects for which a consensus actually exists, the controversies and, when possible, suggested directions for future research.

  6. 2009 Elections: The Candidates Statements

    ERIC Educational Resources Information Center

    TechTrends: Linking Research and Practice to Improve Learning, 2009

    2009-01-01

    This article presents the candidates for the 2009 Association for Educational Communications and Technology (AECT) election and their statements. The candidates are: (1) Andy Gibbons (President-Elect); (2) Barbara B. Lockee (President-Elect); (3) Mary Jean Bishop (At-Large Representative); and (4) Deepak Subramony (At-Large Representative). In…

  7. Financial Statements: Disclosures and Presentations.

    DTIC Science & Technology

    1985-12-01

    in the notes N, to the financial statements. (Church’s Fried Chicken , Inc., 1984 Annual Report, p. 31.) 5. Coatageies Th cmpnyidfedigliigatiomencd 91...expenditures incurred on the Company’s IlUinois coal property and of unrecovered advance royalties recorded on certain Kentucky coal leases. The realizable value

  8. Policy Statements and Position Papers.

    ERIC Educational Resources Information Center

    Journal of Dental Education, 1981

    1981-01-01

    The American Association of Dental Schools' policy statements on elements of preprofessional, predoctoral, advanced, continuing, and auxiliary education and research, and delivery of care are presented. Position papers on peer review, freedoms and responsibilities of individuals and institutions, national health programs, interdisciplinary…

  9. Paradigm Statements of Educational Objectives.

    ERIC Educational Resources Information Center

    Gray, Peter J.

    Five distinct format categories are used in this study to describe the form of educational objectives: clarity, range, level of abstractness, behavioralness, and observability. These form concepts are used to describe paradigm statements of three kinds of educational objectives: goals, intended learning outcomes, and behavioral evidence. Goals are…

  10. Graphs as Statements of Belief.

    ERIC Educational Resources Information Center

    Lake, David

    2002-01-01

    Identifies points where beliefs are important when making decisions about how graphs are drawn. Describes a simple case of the reaction between 'bicarb soda' and orange or lemon juice and discusses how drawing a graph becomes a statement of belief. (KHR)

  11. Statement on Spelling of Metre.

    ERIC Educational Resources Information Center

    Metric Association, Inc., Boulder, CO.

    This report was prepared by the United States Metric Association (USMA) to present supportive evidence on the desirability of using the international English language spelling, metre, for the International System of Units (SI) unit of length, and litre for the common metric unit of volume. It contains a statement by the USMA, some background…

  12. Yavapai College Community Benefits Statements.

    ERIC Educational Resources Information Center

    Salmon, Robert O.; Wing, Barbara; Fairchilds, Angie; Quinley, John W.

    The Yavapai College Districts Board and members of Yavapai College administration and staff developed this report. It contains 12 statements that compromise the core outcomes of the Yavapai College Mission. The extent to which each college addresses these outcomes is then reflected in a series of indicators that are tied to the individual…

  13. Expedition 40 Post Docking Statement

    NASA Image and Video Library

    2014-05-29

    General Director of the Russian Federal Space Agency, Roscosmos, left, and William Gerstenmaier, NASA Associate Administrator for Human Exploration and Operations, right, are seen during a joint statement after the docking of the Soyuz TMA-13M spacecraft with the International Space Station on Thursday, May 29, 2014 at the Baikonur Hotel in Baikonur, Kazakhstan. Photo Credit: (NASA/Joel Kowsky)

  14. Expedition 40 Post Docking Statement

    NASA Image and Video Library

    2014-05-29

    Oleg Ostapenko, General Director of the Russian Federal Space Agency, Roscosmos, left, and William Gerstenmaier, NASA Associate Administrator for Human Exploration and Operations, right, shake hands following a joint statement after the docking of the Soyuz TMA-13M spacecraft with the International Space Station on Thursday, May 29, 2014 at the Baikonur Hotel in Baikonur, Kazakhstan. Photo Credit: (NASA/Joel Kowsky)

  15. School Library Policy Statement. Revised.

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education and Training, Winnipeg. Instructional Services Branch.

    A school library program is a basic component of education for all students. Manitoba Education and Training (MET) presents this policy statement to clarify the roles of the provincial government and the school districts in providing school library services. MET will provide policy and guideline documents to recommend standards, and funding…

  16. Early Childhood Education; Policy Statement.

    ERIC Educational Resources Information Center

    American Foundation for the Blind, New York, NY.

    Provided by the American Foundation for the Blind are a background history and a policy statement on the early childhood education of blind or severely visually impaired children. Briefly reviewed is the prior trend of institutionalization for children with severe visual handicaps, subsequent development of organizations such as the Children's…

  17. Graphs as Statements of Belief.

    ERIC Educational Resources Information Center

    Lake, David

    2002-01-01

    Identifies points where beliefs are important when making decisions about how graphs are drawn. Describes a simple case of the reaction between 'bicarb soda' and orange or lemon juice and discusses how drawing a graph becomes a statement of belief. (KHR)

  18. IFSP Outcome Statements Made Simple

    ERIC Educational Resources Information Center

    Shelden, M'Lisa L.; Rush, Dathan D.

    2014-01-01

    A critical component for implementing evidence-based early intervention supports and services is the ability to write family-centered, functional, participation-based outcomes. Participation-based outcome statements that are family-focused center on the desires and needs of the parents or other care providers and are based on their interest in…

  19. 2009 Elections: The Candidates Statements

    ERIC Educational Resources Information Center

    TechTrends: Linking Research and Practice to Improve Learning, 2009

    2009-01-01

    This article presents the candidates for the 2009 Association for Educational Communications and Technology (AECT) election and their statements. The candidates are: (1) Andy Gibbons (President-Elect); (2) Barbara B. Lockee (President-Elect); (3) Mary Jean Bishop (At-Large Representative); and (4) Deepak Subramony (At-Large Representative). In…

  20. Policy Statements and Position Papers.

    ERIC Educational Resources Information Center

    Journal of Dental Education, 1983

    1983-01-01

    Policy statements and position papers are presented that are intended as recommendations and guidelines for member institutions. They cover education, research, delivery of care, peer review, freedoms and responsibilities of individuals and institutions, national health programs, interdisciplinary education, radiation, and due process. (MLW)