Sample records for common bedbug cimex
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Bedbugs and Infectious Diseases
Blanc, Véronique; Del Giudice, Pascal; Levy-Bencheton, Anna; Chosidow, Olivier; Marty, Pierre; Brouqui, Philippe
2011-01-01
Bedbugs are brown and flat hematophagous insects. The 2 cosmopolite species, Cimex lectularius and Cimex hemipterus, feed on humans and/or domestic animals, and recent outbreaks have been reported in occidental countries. Site assessment for bedbug eradication is complex but can be assured, despite emerging insecticide resistance, by hiring a pest-control manager. The common dermatological presentation of bites is an itchy maculopapular wheal. Urticarial reactions and anaphylaxis can also occur. Bedbugs are suspected of transmitting infectious agents, but no report has yet demonstrated that they are infectious disease vectors. We describe 45 candidate pathogens potentially transmitted by bedbugs, according to their vectorial capacity, in the wild, and vectorial competence, in the laboratory. Because of increasing demands for information about effective control tactics and public health risks of bedbugs, continued research is needed to identify new pathogens in wild Cimex species (spp) and insecticide resistance. PMID:21288844
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Tawatsin, Apiwat; Thavara, Usavadee; Chompoosri, Jakkrawarn; Phusup, Yutthana; Jonjang, Nisarat; Khumsawads, Chayada; Bhakdeenuan, Payu; Sawanpanyalert, Pathom; Asavadachanukorn, Preecha; Mulla, Mir S; Siriyasatien, Padet; Debboun, Mustapha
2011-09-01
Bedbugs are found in many countries around the world, and in some regions they are resistant to numerous insecticides. This study surveyed bedbugs in Thailand and determined their resistance to insecticides. The surveys were carried out in six provinces that attract large numbers of foreign tourists: Bangkok, Chonburi, Chiang Mai, Ubon Ratchathani, Phuket, and Krabi. Bedbugs were collected from hotels and colonized in the laboratory to evaluate their resistance to insecticides. Cimex hemipterus (F.) was found in some hotels in Bangkok, Chonburi, Phuket, and Krabi, whereas Cimex lectularius L. was found only in hotels in Chiang Mai. No bedbugs were found in Ubon Ratchathani. The colonized bedbugs showed resistance to groups of insecticides, including organochlorines (dichlorodiphenyl trichloroethane, dieldrin), carbamates (bendiocarb, propoxur), organophosphates (malathion, fenitrothion), and pyrethroids (cyfluthrin, deltamethrin, permethrin, lambda-cyhalothrin, etofenprox) in tests using World Health Organization insecticide-impregnated papers. The new insecticides imidacloprid (neonicotinoid group), chlorfenapyr (pyrrole group), and fipronil (phenylpyrazole group) were effective against the bedbugs; however, organophosphate (diazinon), carbamates (fenobucarb, propoxur), and pyrethroids (bifenthrin, cypermethrin, esfenvalerate, etofenprox) were ineffective. Aerosols containing various pyrethroid insecticides with two to four different active ingredients were effective against the bedbugs. The results obtained from this study suggested that both species of bedbugs in Thailand have developed marked resistance to various groups of insecticides, especially those in the pyrethroid group, which are the most common insecticides used for pest control. Therefore, an integrated pest management should be implemented for managing bedbugs in Thailand.
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Reemergence of the bedbug Cimex lectularius in Seoul, Korea
Lee, In-Yong; Ree, Han-Il; An, Song-Jun; Linton, John Alderman
2008-01-01
A healthy 30-yr-old woman carrying an insect that had been caught in her living room visited the International Clinic at Severance Hospital, Seoul, in December 2007. The insect she brought was identified to be a nymph of a bedbug, Cimex lectularius, and her skin rashes looked typical bedbug's bites. Her apartment was investigated, and a dead body of a bedbug, cast skins, and hatched eggs were found in her rooms and neighbors' rooms in the same building. She was living in that apartment in Seoul for 9 months since she had moved from New Jersey, USA. We assume that the bedbugs were introduced from abroad, since there had been no report on bedbugs in Seoul for more than 2 decades at least. This is a report of a reemergence of the common bedbug, C. lectularius in Seoul, Korea. PMID:19127335
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Kweka, Eliningaya J; Mwang'onde, Beda J; Kimaro, Epiphania E; Msangi, Shandala; Tenu, Filemoni; Mahande, Aneth M
2009-01-01
The recent spread of bedbugs, Cimex lectularius L. (Heteroptera: Cimicidae), has received attention of the public health sector for designing of effective plan of action for control. Several studies have focused on determining the distribution and abundance of bedbug populations in tropical areas. This study establishes baseline information on deltamethrin, permethrin, alphacypermethrin, lambdacypermethrin and K-O tab susceptibility status in a bedbug population collected from Magugu area in northern Tanzania. The evolution of insecticide resistance could be a primary factor in explaining this resurgence of bedbugs in many areas, both rural and urban. Evaluation of the bedbug population from houses in Magugu indicates that the population of bedbugs is susceptible to pyrethroid insecticides, which are commonly used. Without the development of new tactics for bedbug resistance management, further escalation of this public health problem should be expected when resistant gene spreads within the population. These results suggest that although all concentrations kill bedbugs, more evaluations should be done using WHO kits and mechanisms involved in pyrethroid resistance should be evaluated, such as metabolic and knockdown resistance gene, to have a broad picture for better design of control methodologies. PMID:20300399
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Kaeng Khoi virus from naturally infected bedbugs (Cimicidae) and immature free-tailed bats*
Williams, James E.; Imlarp, Somsak; Top, Franklin H.; Cavanaugh, Dan C.; Russell, Philip K.
1976-01-01
Kaeng Khoi virus was recovered from bedbugs (Stricticimex parvus and Cimex insuetus) and from suckling wrinkle-lipped bats (Tadarida plicata) collected in central Thailand. The data implicate bedbugs as possible vectors of this virus. PMID:1086729
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Human travel and traveling bedbugs.
Delaunay, Pascal
2012-12-01
A dramatic increase of reported bedbug (Cimex lectularius and Cimex hemipterus) infestations has been observed worldwide over the past decade. Bedbug infestations have also been detected across a wide range of travel accommodations, regardless of their comfort and hygiene levels. Travelers are increasingly exposed to the risks of bedbug bites, infestation of personal belongings, and subsequent contamination of newly visited accommodations and their homes. We searched Medline publications via the PubMed database. National bedbug recommendations, textbooks, newspapers, and Centers for Disease Control websites were also searched manually. To detect infested sites, avoid or limit bedbug bites, and reduce the risk of contaminating one's belongings and home, bedbug biology and ecology must be understood. A detailed search of their most classic hiding niches is a key to finding adult bedbugs, nymphs, eggs, and feces or traces of blood from crushed bedbugs. Locally, bedbugs move by active displacement to feed (bite) during the night. Bed, mattress, sofa, and/or curtains are the most frequently infested places. If you find bedbugs, change your room or, even better, the hotel. Otherwise, travelers should follow recommendations for avoiding bedbugs and their bites during the night and apply certain simple rules to avoid infesting other sites or their home. Travelers exposed to bedbugs can minimize the risks of bites and infestation of their belongings, and must also do their civic duty to avoid contributing to the subsequent contamination of other hotels and, finally, home. © 2012 International Society of Travel Medicine.
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Co-speciation in bedbug Wolbachia parallel the pattern in nematode hosts.
Balvín, Ondřej; Roth, Steffen; Talbot, Benoit; Reinhardt, Klaus
2018-06-11
Wolbachia bacteria, vertically transmitted intracellular endosymbionts, are associated with two major host taxa in which they show strikingly different symbiotic modes. In some taxa of filarial nematodes, where Wolbachia are strictly obligately beneficial to the host, they show complete within- and among-species prevalence as well as co-phylogeny with their hosts. In arthropods, Wolbachia usually are parasitic; if beneficial effects occurs, they can be facultative or obligate, related to host reproduction. In arthropods, the prevalence of Wolbachia varies within and among taxa, and no co-speciation events are known. However, one arthropod species, the common bedbug Cimex lectularius was recently found to be dependent on the provision of biotin and riboflavin by Wolbachia, representing a unique case of Wolbachia providing nutritional and obligate benefits to an arthropod host, perhaps even in a mutualistic manner. Using the presence of presumably functional biotin gene copies, our study demonstrates that the obligate relationship is maintained at least in 10 out of 15 species of the genera Cimex and Paracimex. The remaining five species harboured Wolbachia as well, demonstrating the first known case of 100% prevalence of Wolbachia among higher arthropod taxa. Moreover, we show the predicted co-cladogenesis between Wolbachia and their bedbug hosts, also as the first described case of Wolbachia co-speciation in arthropods.
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Sensitivity to bites by the bedbug, Cimex lectularius.
Reinhardt, K; Kempke, D; Naylor, R A; Siva-Jothy, M T
2009-06-01
Bedbugs are a public health problem and can cause significant economic losses, but little is known about the effects of bites on humans. We reviewed case reports and published papers on bedbug bites to assess the empirical basis of the commonly cited figure that only approximately 80% of the population are sensitive to bedbug bites. We found the sensitivity estimate to be based on only one study carried out 80 years ago. However, this study did not account for the now well-established fact that only repeated exposure to external allergens leads to skin reactions. In our sample, 18 of 19 persons showed a skin reaction after bedbug exposure, but in most cases only after repeated controlled exposure. With repeated exposure, the latency between bite and skin reactions decreased from approximately 10 days to a few seconds. Our results are relevant for the hospitality industry, where apparently increasing infestation rates are likely to lead to an increase in the number of tourists and hotel employees exposed to bedbugs. Medical and public health professionals may expect to see an increase in the prevalence of people with bedbug bite sensitivity. The significance of the delayed reaction time of skin to bites may also have implications in litigation cases where people seek compensation.
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Omudu, E A; Kuse, C N
2010-12-01
The common bedbug Cimex lectularius Linnaeus 1758 (Hemiptera: Cimicidae) is a globally re-emerging pest of serious public health concern. We investigated bedbug infestation in randomly selected apartments in Gbajimba community in Guma Local Government area in Benue state, Nigeria. Beddings and furniture (bed frames, pillows, mattresses, cushion chairs, mats, mosquito nets and bamboo beds) were thoroughly inspected for bedbug infestation using the hand-picking technique. Data were analysed using chi- square analysis for differences in the infestation levels in harbourages and sampling locations. Only 16% of the apartments investigated showed no evidence of bedbug infestation as egg cases and faecal marks were sighted in 62.2% of apartments surveyed. The highest infestation rate was observed in Angwan Jukun area and infestation here was higher compared to other study locations within the town though the difference was not statistically significant (x2 = 7.92, df = 6, p >0.05). Bamboo beds harboured the highest number of bedbugs collected, accounting for 35.8%, while other harbourages like iron bed frames and sleeping mats had 23 and 22.7% infestation rates respectively. The infestation rates in these household items were significantly higher than other items inspected (x2 = 11.8, df = 4, p > 0.05). This study demonstrates the urgent need for identification of evidences of infestation and bedbug management involving community participation in inspection, detection and education, including physical removal and exclusion as well as pesticide application.
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Sõukand, Renata; Kalle, Raivo; Svanberg, Ingvar
2010-01-01
Extensive folklore records from pre-modern Estonia give us an excellent opportunity to study a variety of local plant knowledge and plant use among the peasantry in various parts of the country. One important biocultural domain where plant knowledge has been crucial was in the various methods of combating different ectoparasites that cohabited and coexisted with humans and their domestic animals. Some of these methods were widely known (world-wide, Eurasia, Europe, Baltic Rim), while others were more local. Here we discuss ways of reducing clothes moths Tineola bisselliella (Hummel) (Lepidoptera: Tineidae), human fleas Pulex irritons L. (Siphonaptera: Pulicidae) and bedbugs Cimex lectularius L. (Hemiptera: Cimicidae) with the help of plants. Various taxa used as traditional repellents have been identified. The use of plants as repellents and their toxic principles are also discussed from a comparative perspective. PMID:21070174
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Sõukand, Renata; Kalle, Raivo; Svanberg, Ingvar
2010-01-01
Extensive folklore records from pre-modern Estonia give us an excellent opportunity to study a variety of local plant knowledge and plant use among the peasantry in various parts of the country. One important biocultural domain where plant knowledge has been crucial was in the various methods of combating different ectoparasites that cohabited and coexisted with humans and their domestic animals. Some of these methods were widely known (world-wide, Eurasia, Europe, Baltic Rim), while others were more local. Here we discuss ways of reducing clothes moths Tineola bisselliella (Hummel) (Lepidoptera: Tineidae), human fleas Pulex irritons L. (Siphonaptera: Pulicidae) and bedbugs Cimex lectularius L. (Hemiptera: Cimicidae) with the help of plants. Various taxa used as traditional repellents have been identified. The use of plants as repellents and their toxic principles are also discussed from a comparative perspective.
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Suppression of Bedbug’s Reproduction by RNA Interference of Vitellogenin
Moriyama, Minoru; Hosokawa, Takahiro; Tanahashi, Masahiko; Nikoh, Naruo; Fukatsu, Takema
2016-01-01
Recent resurgence of the bedbug Cimex lectularius is a global problem on the public health. On account of the worldwide rise of insecticide-resistant bedbug populations, exploration of new approaches to the bedbug control and management is anticipated. In this context, gene silencing by RNA interference (RNAi) has been considered for its potential application to pest control and management, because RNAi enables specific suppression of target genes and thus flexible selection of target traits to be disrupted. In this study, in an attempt to develop a control strategy targeting reproduction of the bedbug, we investigated RNAi-mediated gene silencing of vitellogenin (Vg), a major yolk protein precursor essential for oogenesis. From the bedbug transcriptomes, we identified a typical Vg gene and a truncated Vg gene, which were designated as ClVg and ClVg-like, respectively. ClVg gene was highly expressed mainly in the fat body of adult females, which was more than 100 times higher than the expression level of ClVg-like gene, indicating that ClVg gene is the primary functional Vg gene in the bedbug. RNAi-mediated suppression of ClVg gene expression in adult females resulted in drastically reduced egg production, atrophied ovaries, and inflated abdomen due to hypertrophied fat bodies. These phenotypic consequences are expected not only to suppress the bedbug reproduction directly but also to deteriorate its feeding and survival indirectly via behavioral modifications. These results suggest the potential of ClVg gene as a promising target for RNAi-based population management of the bedbug. PMID:27096422
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Reducing a cost of traumatic insemination: female bedbugs evolve a unique organ.
Reinhardt, Klaus; Naylor, Richard; Siva-Jothy, Michael T
2003-01-01
The frequent wounding of female bedbugs (Cimex lectularius: Cimicidae) during copulation has been shown to decrease their fitness, but how females have responded to this cost in evolutionary terms is unclear. The evolution of a unique anatomical structure found in female bedbugs, the spermalege, into which the male's intromittent organ passes during traumatic insemination, is a possible counteradaptation to harmful male traits. Several functions have been proposed for this organ, and we test two hypotheses related to its role in sexual conflict. We examine the hypotheses that the spermalege functions to (i) defend against pathogens introduced during traumatic insemination; and (ii) reduce the costs of wound healing during traumatic insemination. Our results support the 'defence against pathogens' hypothesis, suggesting that the evolution of this unique cimicid organ resulted, at least partly, from selection to reduce the costs of mating-associated infection. We found no evidence that the spermalege reduces the costs of wound healing. PMID:14667353
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Vail, K M; Chandler, J G
2017-06-01
Bed bug, Cimex lectularius L., management in low-income, high-rise housing for the elderly and disabled can be difficult. Early detection is key to slowing their spread, and reducing management cost and time needed for control. To determine the minimum number of passive monitors needed to detect low-level bed bug infestations in this environment, we evaluated three monitors placed one, two, or four per apartment in a 3 by 3 experimental design. One sticky monitor, The Bedbug Detection System, and the two pitfall monitors, ClimbUp Insect Interceptors BG and BlackOut BedBug Detectors, were evaluated. Bed bugs were trapped by the ClimbUp Insect Interceptors BG and the BlackOut BedBug Detector in 88% and 79% of apartments, respectively, but only in 39% of the apartments monitored with The Bedbug Detection System. The Bedbug Detection System required significantly longer time to detect bed bugs than either the ClimbUp Insect Interceptor BG or the BlackOut BedBug Detector. With the less effective Bedbug Detection System data removed from analyses, detection rates ranged from 80 to 90%, with no significant differences among one, two, or four monitors per apartment. Results indicate it is especially important to include a bed placement when only placing a few monitors. Future work should compare the combination of cursory visual inspections with various monitor numbers and placements per apartment to determine the most efficient, cost-effective system that will be accepted and implemented in low-income housing. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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Reinhardt, Klaus; Breunig, Hans Georg; Uchugonova, Aisada; König, Karsten
2015-01-01
We explore the possibility of characterizing sperm cells without the need to stain them using spectral and fluorescence lifetime analyses after multi-photon excitation in an insect model. The autofluorescence emission spectrum of sperm of the common bedbug, Cimex lectularius, was consistent with the presence of flavins and NAD(P)H. The mean fluorescence lifetimes showed smaller variation in sperm extracted from the male (tau m, τm = 1.54–1.84 ns) than in that extracted from the female sperm storage organ (tau m, τm = 1.26–2.00 ns). The fluorescence lifetime histograms revealed four peaks. These peaks (0.18, 0.92, 2.50 and 3.80 ns) suggest the presence of NAD(P)H and flavins and show that sperm metabolism can be characterized using fluorescence lifetime imaging. The difference in fluorescence lifetime variation between the sexes is consistent with the notion that female animals alter the metabolism of sperm cells during storage. It is not consistent, however, with the idea that sperm metabolism represents a sexually selected character that provides females with information about the male genotype. PMID:26333813
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Eom, In-Yong; Risticevic, Sanja; Pawliszyn, Janusz
2012-02-24
Air in a room infested by Cimex lectularius L. (Hemiptera: Cimicidae) was sampled simultaneously by three different sampling devices including solid phase microextraction (SPME) fiber coatings, thin film microextraction (TFME) devices, and needle trap devices (NTDs) and then analyzed by gas chromatography-mass spectrometry (GC-MS). The main focus of this study was to fully characterize indoor air by identifying compounds extracted by three different microextraction formats and, therefore, perform both the device comparison and more complete characterization of C. lectularius pheromone. The NTD technique was capable of extracting both (E)-2-hexenal and (E)-2-octenal, which were previously identified as alarm pheromones of bedbugs, and superior NTD recoveries for these two components allowed reliable identification based on mass spectral library searching and linear temperature programmed retention index (LTPRI) technique. While the use of DVB/CAR/PDMS SPME fiber coatings provided complementary sample fingerprinting and profiling results, TFME sampling devices provided discriminative extraction coverage toward highly volatile analytes. In addition to two alarm pheromones, relative abundances of all other analytes were recorded for all three devices and aligned across all examined samples, namely, highly infested area, less infested area, and control samples which were characterized by different bedbug populations. The results presented in the current study illustrate comprehensive characterization of infested indoor air samples through the use of three different non-invasive SPME formats and identification of novel components comprising C. lectularius pheromone, therefore, promising future alternatives for use of potential synthetic pheromones for detection of infestations. Copyright © 2011 Elsevier B.V. All rights reserved.
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Wolbachia as a bacteriocyte-associated nutritional mutualist
Hosokawa, Takahiro; Koga, Ryuichi; Kikuchi, Yoshitomo; Meng, Xian-Ying; Fukatsu, Takema
2009-01-01
Many insects are dependent on bacterial symbionts that provide essential nutrients (ex. aphid–Buchnera and tsetse–Wiglesworthia associations), wherein the symbionts are harbored in specific cells called bacteriocytes that constitute a symbiotic organ bacteriome. Facultative and parasitic bacterial symbionts like Wolbachia have been regarded as evolutionarily distinct from such obligate nutritional mutualists. However, we discovered that, in the bedbug Cimex lectularius, Wolbachia resides in a bacteriome and appears to be an obligate nutritional mutualist. Two bacterial symbionts, a Wolbachia strain and an unnamed γ-proteobacterium, were identified from different strains of the bedbug. The Wolbachia symbiont was detected from all of the insects examined whereas the γ-proteobacterium was found in a part of them. The Wolbachia symbiont was specifically localized in the bacteriomes and vertically transmitted via the somatic stem cell niche of germalia to oocytes, infecting the incipient symbiotic organ at an early stage of the embryogenesis. Elimination of the Wolbachia symbiont resulted in retarded growth and sterility of the host insect. These deficiencies were rescued by oral supplementation of B vitamins, confirming the essential nutritional role of the symbiont for the host. The estimated genome size of the Wolbachia symbiont was around 1.3 Mb, which was almost equivalent to the genome sizes of parasitic Wolbachia strains of other insects. These results indicate that bacteriocyte-associated nutritional mutualism can evolve from facultative and prevalent microbial associates like Wolbachia, highlighting a previously unknown aspect of the parasitism-mutualism evolutionary continuum. PMID:20080750
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Male Mating Rate Is Constrained by Seminal Fluid Availability in Bedbugs, Cimex lectularius
Reinhardt, Klaus; Naylor, Richard; Siva-Jothy, Michael T.
2011-01-01
Sexual selection, differences in reproductive success between individuals, continues beyond acquiring a mating partner and affects ejaculate size and composition (sperm competition). Sperm and seminal fluid have very different roles in sperm competition but both components encompass production costs for the male. Theoretical models predict that males should spend ejaculate components prudently and differently for sperm and seminal fluid but empirical evidence for independent variation of sperm number and seminal fluid volume is scarce. It is also largely unknown how sperm and seminal fluid variation affect future mating rate. In bedbugs we developed a protocol to examine the role of seminal fluids in ejaculate allocation and its effect on future male mating rate. Using age-related changes in sperm and seminal fluid volume we estimated the lowest capacity at which mating activity started. We then showed that sexually active males allocate 12% of their sperm and 19% of their seminal fluid volume per mating and predicted that males would be depleted of seminal fluid but not of sperm. We tested (and confirmed) this prediction empirically. Finally, the slightly faster replenishment of seminal fluid compared to sperm did not outweigh the faster decrease during mating. Our results suggest that male mating rate can be constrained by the availability of seminal fluids. Our protocol might be applicable to a range of other organisms. We discuss the idea that economic considerations in sexual conflict research might benefit from distinguishing between costs and benefits that are ejaculate dose-dependent and those that are frequency-dependent on the mating rate per se. PMID:21779378
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Reinhardt, Klaus; Naylor, Richard A.; Siva-Jothy, Michael T.
2009-01-01
Increased female reproductive rates usually result in accelerated senescence. This correlation provides a link between the evolutionary conflict of the sexes and aging when ejaculate components elevate female reproductive rates at the cost of future reproduction. It is not clear whether this female cost is manifest as shorter lifespan or an earlier onset or a steeper rate of reproductive senescence. It also is unclear whether beneficial ejaculates release females from reproductive trade-offs and, if so, which senescence parameters are affected. We examined these issues in the bedbug, Cimex lectularius, a long-lived insect that shows reduced female lifespan as well as female reproductive senescence at the male-determined mating frequency. We demonstrate experimentally that, independently of the mating frequency, females receiving more ejaculate show increased reproductive rates and enter reproductive senescence later than females receiving less ejaculate. The rate of reproductive senescence did not differ between treatments, and reproductive rates did not predict mortality. The ejaculate effects were consistent in inter- and intra-population crosses, suggesting they have not evolved recently and are not caused by inbreeding. Our results suggest that ejaculate components compensate for the costs of elevated female reproductive rates in bedbugs by delaying the onset of reproductive senescence. Ejaculate components that are beneficial to polyandrous females could have arisen because male traits that protect the ejaculate have positive pleiotropic effects and/or because female counteradaptations to antagonistic male traits exceed the neutralization of those traits. That males influence female reproductive senescence has important consequences for trade-offs between reproduction and longevity and for studies of somatic senescence. PMID:19996174
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Gürtler, R E; Oneto, M L; Cecere, M C; Castañera, M B; Canale, D M
2001-03-01
We successfully applied the phenolphthalin (Kastle-Meyer) test used in forensic chemistry to distinguish between feces from triatomines and other domestic arthropods in sensing devices used for vector surveillance. All black or dark brown, but not white or yellow, fecal smears from laboratory-reared or field-collected Triatoma infestans Klug, Triatoma guasayana Wydgozinsky & Abalos, Triatoma sordida Ståhl (recently revalidated as Triatoma garciabesi Carcavallo, Cichero, Martínez, Prosen & Ronderos) tested positive, whereas dejecta from cockroaches and spiders, crickets, beetles, predatory bugs, and domestic flies tested negative. Black or dark brown dejecta from female Aedes aegypti L. and Cimex lectularius L. bedbugs also tested positive. In sellsing devices installed in bedrooms of 11 houses in Amamá, rural northwestern Argentina, where neither cimicid bedbugs nor argasid ticks had been found over the years, only 62% of the black or dark brown fecal smears attributed to triatomines by a skilled observer tested phenolphthalin-positive. After insecticidal spraying, when bedroom areas were not colonized by triatomines, only 33-40% of the black or dark brown fecal smears in sensor boxes attributed to triatomines by another skilled observer tested phenolphthalin-positive. Eleven (79%) ofthe 14 houses with dubious or nontypical triatomine feces tested phenolphthalin-positive at least once during 1993-1995. Our study introduces a low-cost, simple and effective procedure for the identification of triatomine feces. The test, as a helpful adjunct to sensing devices used in triatomine surveillance, will aid in the accurate detection of infestations and the determination of the need for insecticide application.
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Evolutionary origin of insect–Wolbachia nutritional mutualism
Nikoh, Naruo; Hosokawa, Takahiro; Moriyama, Minoru; Oshima, Kenshiro; Hattori, Masahira; Fukatsu, Takema
2014-01-01
Obligate insect–bacterium nutritional mutualism is among the most sophisticated forms of symbiosis, wherein the host and the symbiont are integrated into a coherent biological entity and unable to survive without the partnership. Originally, however, such obligate symbiotic bacteria must have been derived from free-living bacteria. How highly specialized obligate mutualisms have arisen from less specialized associations is of interest. Here we address this evolutionary issue by focusing on an exceptional insect–Wolbachia nutritional mutualism. Although Wolbachia endosymbionts are ubiquitously found in diverse insects and generally regarded as facultative/parasitic associates for their insect hosts, a Wolbachia strain associated with the bedbug Cimex lectularius, designated as wCle, was shown to be essential for host’s growth and reproduction via provisioning of B vitamins. We determined the 1,250,060-bp genome of wCle, which was generally similar to the genomes of insect-associated facultative Wolbachia strains, except for the presence of an operon encoding the complete biotin synthetic pathway that was acquired via lateral gene transfer presumably from a coinfecting endosymbiont Cardinium or Rickettsia. Nutritional and physiological experiments, in which wCle-infected and wCle-cured bedbugs of the same genetic background were fed on B-vitamin–manipulated blood meals via an artificial feeding system, demonstrated that wCle certainly synthesizes biotin, and the wCle-provisioned biotin significantly contributes to the host fitness. These findings strongly suggest that acquisition of a single gene cluster consisting of biotin synthesis genes underlies the bedbug–Wolbachia nutritional mutualism, uncovering an evolutionary transition from facultative symbiosis to obligate mutualism facilitated by lateral gene transfer in an endosymbiont lineage. PMID:24982177
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Bedbugs Overview Bedbugs are small, reddish-brown parasitic insects that bite the exposed skin of sleeping humans and animals to feed on their blood. Although bedbugs aren't known to spread disease, they can ...
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An insight into the sialome of the bed bug, Cimex lectularius
Francischetti, Ivo M.B.; Calvo, Eric; Andersen, John F.; Pham, Van M.; Favreau, Amanda J.; Barbian, Kent D.; Romero, Alvaro; Valenzuela, Jesus G.; Ribeiro., José M.C.
2010-01-01
The evolution of insects to a blood diet leads to the development of a saliva that antagonizes their hosts' hemostasis and inflammation. Hemostasis and inflammation are redundant processes, and thus a complex salivary potion comprised of dozens or near one hundred different polypeptides is commonly found by transcriptome or proteome analysis of these organisms. Several insect orders or families evolved independently to hematophagy creating unique salivary potions in the form of novel pharmacological use of endogenous substances, and in the form of unique proteins not matching other known proteins, these probably arriving by fast evolution of salivary proteins as they evade their hosts' immune response. In this work we present a preliminary description of the sialome (from the Greek Sialo = saliva) of the common bed bug Cimex lectularius, the first such work from a member of the Cimicidae family. This manuscript is a guide for the supplemental database files http://exon.niaid.nih.gov/transcriptome/C_lectularius/S1/Cimex-S1.zip and http://exon.niaid.nih.gov/transcriptome/C_lectularius/S2/Cimex-S2.xls PMID:20441151
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Insight into the Sialome of the Bed Bug, Cimex lectularius.
Francischetti, Ivo M B; Calvo, Eric; Andersen, John F; Pham, Van M; Favreau, Amanda J; Barbian, Kent D; Romero, Alvaro; Valenzuela, Jesus G; Ribeiro, José M C
2010-08-06
The evolution of insects to a blood diet leads to the development of a saliva that antagonizes their hosts' hemostasis and inflammation. Hemostasis and inflammation are redundant processes, and thus a complex salivary potion composed of dozens or near 100 different polypeptides is commonly found by transcriptome or proteome analysis of these organisms. Several insect orders or families evolved independently to hematophagy, creating unique salivary potions in the form of novel pharmacological use of endogenous substances and in the form of unique proteins not matching other known proteins, these probably arriving by fast evolution of salivary proteins as they evade their hosts' immune response. In this work we present a preliminary description of the sialome (from the Greek Sialo = saliva) of the common bed bug Cimex lectularius, the first such work from a member of the Cimicidae family. This manuscript is a guide for the supplemental database files http://exon.niaid.nih.gov/transcriptome/C_lectularius/S1/Cimex-S1.zip and http://exon.niaid.nih.gov/transcriptome/C_lectularius/S2/Cimex-S2.xls.
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Jones, Susan C; Bryant, Joshua L
2012-06-01
Field-collected bed bugs (Cimex lectularius L.) showed little, if any, adverse effects after 2-h direct exposure to the aerosolized pyrethroid(s) from three over-the-counter total-release foggers ('bug bombs' or 'foggers'); Hotshot Bedbug and Flea Fogger, Spectracide Bug Stop Indoor Fogger, and Eliminator Indoor Fogger. One field-collected population, EPM, was an exception in that there was significant mortality at 5-7 d when bugs out in the open had been exposed to the Spectracide Fogger; mortality was low when these bugs had access to an optional harborage, a situation observed for all field-collected populations when exposed to the three foggers. Even the Harlan strain, the long-term laboratory population that is susceptible to pyrethroids and that served as an internal control in these experiments, was unaffected if the bugs were covered by a thin cloth layer that provided harborage. In residences and other settings, the majority of bed bugs hide in protected sites where they will not be directly contracted by the insecticide mist from foggers. This study provides the first scientific data supporting the position that total-release foggers should not be recommended for control of bed bugs, because 1) many field-collected bed bugs are resistant to pyrethroids, and they are not affected by brief exposure to low concentrations of pyrethrins and/or pyrethroids provided by foggers; and 2) there is minimal, if any, insecticide penetration into typical bed bug harborage sites. This study provides strong evidence that Hotshot Bedbug and Flea Fogger, Spectracide Bug Stop Indoor Fogger, and Eliminator Indoor Fogger were ineffective as bed bug control agents.
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USDA-ARS?s Scientific Manuscript database
The common bed bug (Cimex lectularius L.) resurged in the U.S. and many other countries over the past decade. The need for safe and effective bed bug control products propelled the development of numerous “green pesticides”, mostly with essential oils listed as active ingredients. Various inorganic ...
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... Staying Safe Videos for Educators Search English Español Hey! A Bedbug Bit Me! KidsHealth / For Kids / Hey! A Bedbug Bit Me! Print en español ¡Ay! ¡ ... of them. More on this topic for: Kids Hey! A Bee Stung Me! Hey! A Scorpion Stung ...
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Bedbugs: An Equal Opportunist and Cosmopolitan Creature
ERIC Educational Resources Information Center
Krause-Parello, Cheryl A.; Sciscione, Patricia
2009-01-01
Currently there is a rise in bedbugs seen in schools. The wingless, blood-sucking insects can arrive at school via student book bags, student clothing, or other personal items. If a student presents in the health office with a bite mark, the school nurse will need to differentiate between a bedbug bite and other insect bites, such as fleas,…
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Bedbugs in Schools? Halting a Possible Epidemic
ERIC Educational Resources Information Center
Waldorf, Glenn
2012-01-01
Bedbugs are a growing problem in schools today. Bedbugs are often confused with other insects, and their signs are hard to recognize. School officials should work with an experienced pest control company to confirm whether the insects are bed bugs and, if they are not, to identify them so they can be treated effectively. Education and vigilance…
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USDA-ARS?s Scientific Manuscript database
The common bed bug, Cimex lectularius (L.) (Hemiptera: Cimicidae) is undergoing a rapid resurgence in the United States during the last decade which has created a notable pest management challenge largely because the pest has developed resistance against DDT, organophosphates, carbamates, and pyreth...
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Akhtar, Yasmin; Isman, Murray B.
2013-01-01
Background Horizontal transfer of insecticide occurs when insects contact or ingest an insecticide, return to an aggregation or a nest, and transfer the insecticide to other conspecific insects through contact. This phenomenon has been reported in a number of insects including social insects, however it has not been reported in bed bugs. Since horizontal transfer can facilitate the spread of insecticide into hard to reach spaces, it could contribute greatly to the management of these public health pests. Methodology/Results To demonstrate horizontal transfer of diatomaceous earth and botanical insecticides in C. lectularius, an exposed (donor) bed bug, following a 10-minute acquisition period, was placed with unexposed (recipient) bed bugs. Mortality data clearly demonstrates that diatomaceous earth (DE 51) was actively transferred from a single exposed bug to unexposed bugs in a concentration dependent manner. LC50 values varied from 24.4 mg at 48 h to 5.1 mg at 216 h when a single exposed bed bug was placed with 5 unexposed bed bugs. LT50 values also exhibited a concentration response. LT50 values varied from 1.8 days to 8.4 days when a ‘donor’ bug exposed to 20 and 5 mg of dust respectively was placed with 5 ‘recipient’ bugs. Dust was also actively transferred from adult bed bugs to the nymphs. In addition we observed horizontal transfer of botanical insecticides including neem, ryania, and rotenone to varying degrees. Conclusion/Significance Our data clearly demonstrate horizontal transfer of diatomaceous earth and botanical insecticides in the common bed bug, C. lectularius. Use of a fluorescent dust provided visual confirmation that contaminated bed bugs transfer dust to untreated bed bugs in harborage. This result is important because bedbugs live in hard-to-reach places and interaction between conspecifics can be exploited for delivery and dissemination of management products directed at this public health pest. PMID:24086593
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Akhtar, Yasmin; Isman, Murray B
2013-01-01
Horizontal transfer of insecticide occurs when insects contact or ingest an insecticide, return to an aggregation or a nest, and transfer the insecticide to other conspecific insects through contact. This phenomenon has been reported in a number of insects including social insects, however it has not been reported in bed bugs. Since horizontal transfer can facilitate the spread of insecticide into hard to reach spaces, it could contribute greatly to the management of these public health pests. To demonstrate horizontal transfer of diatomaceous earth and botanical insecticides in C. lectularius, an exposed (donor) bed bug, following a 10-minute acquisition period, was placed with unexposed (recipient) bed bugs. Mortality data clearly demonstrates that diatomaceous earth (DE 51) was actively transferred from a single exposed bug to unexposed bugs in a concentration dependent manner. LC50 values varied from 24.4 mg at 48 h to 5.1 mg at 216 h when a single exposed bed bug was placed with 5 unexposed bed bugs. LT50 values also exhibited a concentration response. LT50 values varied from 1.8 days to 8.4 days when a 'donor' bug exposed to 20 and 5 mg of dust respectively was placed with 5 'recipient' bugs. Dust was also actively transferred from adult bed bugs to the nymphs. In addition we observed horizontal transfer of botanical insecticides including neem, ryania, and rotenone to varying degrees. Our data clearly demonstrate horizontal transfer of diatomaceous earth and botanical insecticides in the common bed bug, C. lectularius. Use of a fluorescent dust provided visual confirmation that contaminated bed bugs transfer dust to untreated bed bugs in harborage. This result is important because bedbugs live in hard-to-reach places and interaction between conspecifics can be exploited for delivery and dissemination of management products directed at this public health pest.
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Liedtke, H. Christoph; Åbjörnsson, Kajsa; Harraca, Vincent; Knudsen, Jette T.; Wallin, Erika A.; Hedenström, Erik; Ryne, Camilla
2011-01-01
The recent resurge of bed bug infestations (Cimex spp.; Cimicidae) and their resistance to commonly used pesticides calls for alternative methods of control. Pheromones play an important role in environmentally sustainable methods for the management of many pest insects and may therefore be applicable for the control of bed bugs. The tropical bed bug, Cimex hemipterus, is a temporary ectoparasite on humans and causes severe discomfort. Compared to the common bed bug, Cimex lectularius, little is known about the chemical signalling and pheromone-based behaviour of the tropical species. Here, we show that the antennal morphology and volatile emission of C. hemipterus closely resembles those of C. lectularius and we test their behavioural responses to conspecific odour emissions. Two major volatiles are emitted by male, female and nymph C. hemipterus under stress, (E)-2-hexenal and (E)-2-octenal. Notably, nymph emissions show contrasting ratios of these compounds to adults and are further characterized by the addition of 4-oxo-(E)-2-hexenal and 4-oxo-(E)-2-octenal. The discovery of this nymph pheromone in C. hemipterus is potentially the cause of a repellent effect observed in the bio-tests, where nymph odours induce a significantly stronger repellent reaction in conspecifics than adult odours. Our results suggest that pheromone-based pest control methods developed for C. lectularius could be applicable to C. hemipterus, with the unique nymph blend showing promising practical properties. PMID:21479180
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Otti, Oliver; Deines, Peter; Hammerschmidt, Katrin; Reinhardt, Klaus
2017-01-01
During wounding, tissues are disrupted so that bacteria can easily enter the host and trigger a host response. Both the host response and bacterial communication can occur through quorum sensing (QS) and quorum sensing inhibition (QSI). Here, we characterize the effect of wounding on the host-associated bacterial community of the bed bug. This is a model system where the male is wounding the female during every mating. Whereas several aspects of the microbial involvement during wounding have been previously examined, it is not clear to what extent QS and QSI play a role. We find that the microbiome differs depending on mating and feeding status of female bedbugs and is specific to the location of isolation. Most organs of bedbugs harbor bacteria, which are capable of both QS and QSI signaling. By focusing on the prokaryotic quorum communication system, we provide a baseline for future research in this unique system. We advocate the bedbug system as suitable for studying the effects of bacteria on reproduction and for addressing prokaryote and eukaryote communication during wounding. PMID:29326722
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Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius.
Rosenfeld, Jeffrey A; Reeves, Darryl; Brugler, Mercer R; Narechania, Apurva; Simon, Sabrina; Durrett, Russell; Foox, Jonathan; Shianna, Kevin; Schatz, Michael C; Gandara, Jorge; Afshinnekoo, Ebrahim; Lam, Ernest T; Hastie, Alex R; Chan, Saki; Cao, Han; Saghbini, Michael; Kentsis, Alex; Planet, Paul J; Kholodovych, Vladyslav; Tessler, Michael; Baker, Richard; DeSalle, Rob; Sorkin, Louis N; Kolokotronis, Sergios-Orestis; Siddall, Mark E; Amato, George; Mason, Christopher E
2016-02-02
The common bed bug (Cimex lectularius) has been a persistent pest of humans for thousands of years, yet the genetic basis of the bed bug's basic biology and adaptation to dense human environments is largely unknown. Here we report the assembly, annotation and phylogenetic mapping of the 697.9-Mb Cimex lectularius genome, with an N50 of 971 kb, using both long and short read technologies. A RNA-seq time course across all five developmental stages and male and female adults generated 36,985 coding and noncoding gene models. The most pronounced change in gene expression during the life cycle occurs after feeding on human blood and included genes from the Wolbachia endosymbiont, which shows a simultaneous and coordinated host/commensal response to haematophagous activity. These data provide a rich genetic resource for mapping activity and density of C. lectularius across human hosts and cities, which can help track, manage and control bed bug infestations.
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Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius
Rosenfeld, Jeffrey A.; Reeves, Darryl; Brugler, Mercer R.; Narechania, Apurva; Simon, Sabrina; Durrett, Russell; Foox, Jonathan; Shianna, Kevin; Schatz, Michael C.; Gandara, Jorge; Afshinnekoo, Ebrahim; Lam, Ernest T.; Hastie, Alex R.; Chan, Saki; Cao, Han; Saghbini, Michael; Kentsis, Alex; Planet, Paul J.; Kholodovych, Vladyslav; Tessler, Michael; Baker, Richard; DeSalle, Rob; Sorkin, Louis N.; Kolokotronis, Sergios-Orestis; Siddall, Mark E.; Amato, George; Mason, Christopher E.
2016-01-01
The common bed bug (Cimex lectularius) has been a persistent pest of humans for thousands of years, yet the genetic basis of the bed bug's basic biology and adaptation to dense human environments is largely unknown. Here we report the assembly, annotation and phylogenetic mapping of the 697.9-Mb Cimex lectularius genome, with an N50 of 971 kb, using both long and short read technologies. A RNA-seq time course across all five developmental stages and male and female adults generated 36,985 coding and noncoding gene models. The most pronounced change in gene expression during the life cycle occurs after feeding on human blood and included genes from the Wolbachia endosymbiont, which shows a simultaneous and coordinated host/commensal response to haematophagous activity. These data provide a rich genetic resource for mapping activity and density of C. lectularius across human hosts and cities, which can help track, manage and control bed bug infestations. PMID:26836631
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1987-04-15
themselves to the main task. Civil-Military Cooperation in the WINTEX- CIMEX Exercise? The exercises of the WINTEX- CIMEX series are considered a prime...out successes and improvements resulting from WINTEX- CIMEX . Even the constant demonstration of continuous def icienies and unsolved problems can be...chalked up as a success for this two-year exercise series. From a critical military viewpoint, however, the WINTEX- CIMEX exercise shows clear signs
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Bed Bugs (Cimex lectularius) as Vectors of Trypanosoma cruzi
Salazar, Renzo; Castillo-Neyra, Ricardo; Tustin, Aaron W.; Borrini-Mayorí, Katty; Náquira, César; Levy, Michael Z.
2015-01-01
Populations of the common bed bug, Cimex lectularius, have recently undergone explosive growth. Bed bugs share many important traits with triatomine insects, but it remains unclear whether these similarities include the ability to transmit Trypanosoma cruzi, the etiologic agent of Chagas disease. Here, we show efficient and bidirectional transmission of T. cruzi between hosts and bed bugs in a laboratory environment. Most bed bugs that fed on experimentally infected mice acquired the parasite. A majority of previously uninfected mice became infected after a period of cohabitation with exposed bed bugs. T. cruzi was also transmitted to mice after the feces of infected bed bugs were applied directly to broken host skin. Quantitative bed bug defecation measures were similar to those of important triatomine vectors. Our findings suggest that the common bed bug may be a competent vector of T. cruzi and could pose a risk for vector-borne transmission of Chagas disease. PMID:25404068
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The common bed bug (Cimex lectularius) is a pest – feeding on blood, causing itchy bites and generally irritating their human hosts. EPA and other agencies all consider bed bugs a public health pest, but bed bugs are not known to transmit disease.
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Mobilization Training and Networking Resource Inventory
1990-01-01
CIMEX ...... Winter Exercise, Civil Military Exercise WWMCCS ........... Worldwide Military Command and Control System xvi MOBILIZATION TRAINING AND...MS FTX 9. Readiness for Mobilization Exercise (REMOBE) 10. REX-ALPHA 11. STARCEX 12. WINTEX- CIMEX 13. JCS Remedial Action Projects (RAP) Program 14...This exercise is small, includes high level NATO officials of NATO countries and is held the opposite years of WINTEX- CIMEX . The purpose is to
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Sheele, Johnathan M; Ridge, Gale E
2016-08-01
The recent resurgence of the common bed bug Cimex lectularius L. throughout western industrialized nations has been facilitated in part by the insect becoming pesticide-resistant. Novel control strategies, including xenointoxication, should be considered to combat C. lectularius. Ivermectin, a U.S. Food and Drug Administration (FDA)-approved treatment for several human parasites, and the antiparasitic drug moxidectin, currently being explored in human clinical trials, were evaluated for efficacy against C. lectularius. Results showed that C. lectularius fed on ivermectin or moxidectin blood concentrations of >25 ng/mL and had significantly higher mortality (50-100 %) than controls (0-6 %) by day 13. Bed bugs that survived a blood meal containing >2.5 ng/mL of ivermectin suffered long-term sequelae including reduced fecundity, feeding difficulty, and incomplete ecdysis. Some insects that survived a blood meal containing ≤75 ng/mL moxidectin were able to feed and reproduce.
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Sheele, Johnathan M; Ridge, Gale E; Du, Wenjing; Mallipeddi, Nikhil; Vallabhaneni, Mayur
2017-10-01
The common bed bug, Cimex lectularius L., is a hematophagous ectoparasite that preferentially feeds on humans. Pharmaceuticals present in a person's blood may adversely affect C. lectularius when it feeds. We fed >10,000 C. lectularius on blood samples containing more than 400 different drug doses and drug combinations using an in vitro feeding system to determine insect mortality. The majority of drug doses approximated the peak plasma concentration in humans taking those drugs. Twenty-one drugs were found to cause >17% 12-14-day mortality compared to 8.5% mortality in the control (p < 0.05), but postliminary testing of three of the drugs, famotidine, ethambutol, and primaquine, did not demonstrate an increase in C. lectularius mortality. We also tested 23 drugs for their effects on C. lectularius fecundity. The results may have implications for understanding C. lectularius population dynamics in an infestation.
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Do We Practice What We Preach? Recent Exercises and the Operational Art
1991-04-27
is based purely on availability of research material. In Europe, these exercises include REFORGER, CRESTED EAGLE/CARBON EDGE, WINTEX- CIMEX , LOGEX, and...strategic and tactical deception efforts is totally missing. WINTEX- CIMEX 87 reemphasizes the need for joint deception doctrine. The complementary and...sustainment. In WINTEX- CIMEX 89, the TRADOC Combined Arms Assessment Team (CAAT) concentrated on six areas of interest: Rear Operations, Reconstitution
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1989-09-01
me expand on this thesis just a bit. My contention is that in every exercise, even the ones like Wintex- Cimex which are supposed to test the logistics...Wintex- Cimex and Gallant Eagle, occur every other year and in the off-year there is a complimentary FTX. Addit-ionally, there is usually one big CPX...spares calculations, and other logistics concerns. 3-2 Observation and Participation The researcher observed the winter exercise known as Wintex- Cimex
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Rost-Roszkowska, M M; Vilimova, J; Włodarczyk, A; Sonakowska, L; Kamińska, K; Kaszuba, F; Marchewka, A; Sadílek, D
2017-02-01
Cimicidae are temporary ectoparasites, which means that they cannot obtain food continuously. Both Cimex species examined here, Cimex lectularius (Linnaeus 1758) and Cimex pipistrelli (Jenyns 1839), can feed on a non-natal host, C. lectularius from humans on bats, C. pipistrelli on humans, but never naturally. The midgut of C. lectularius and C. pipistrelli is composed of three distinct regions-the anterior midgut (AMG), which has a sack-like shape, the long tube-shaped middle midgut (MMG), and the posterior midgut (PMG). The different ultrastructures of the AMG, MMG, and PMG in both of the species examined suggest that these regions must fulfill different functions in the digestive system. Ultrastructural analysis showed that the AMG fulfills the role of storing food and synthesizing and secreting enzymes, while the MMG is the main organ for the synthesis of enzymes, secretion, and the storage of the reserve material. Additionally, both regions, the AMG and MMG, are involved in water absorption in the digestive system of both Cimex species. The PMG is the part of the midgut in which spherites accumulate. The results of our studies confirm the suggestion of former authors that the structure of the digestive tract of insects is not attributed solely to diet but to the basic adaptation of an ancestor.
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Liu, Feng; Haynes, Kenneth F; Appel, Arthur G; Liu, Nannan
2014-06-01
Populations of the common bed bug Cimex lectularius (Hemiptera; Cimicidae), a temporary ectoparasite on both humans and animals, have surged in many developed countries. Similar to other haematophagous arthropods, C. lectularius relies on its olfactory system to detect semiochemicals in the environment, including both attractants and repellents. To elucidate the olfactory responses of the common bed bug to commonly used insect chemical repellents, particularly haematophagous repellents, we investigated the neuronal responses of individual olfactory sensilla in C. lectularius' antennae to 52 insect chemical repellents, both synthetic and botanic. Different types of sensilla displayed highly distinctive response profiles. While C sensilla did not respond to any of the insect chemical repellents, Dγ sensilla proved to be the most sensitive in response to terpene-derived insect chemical repellents. Different chemical repellents elicited neuronal responses with differing temporal characteristics, and the responses of the olfactory sensilla to the insect chemical repellents were dose-dependent, with an olfactory response to the terpene-derived chemical repellent, but not to the non-terpene-derived chemical repellents. Overall, this study furnishes a comprehensive map of the olfactory response of bed bugs to commonly used insect chemical repellents, providing useful information for those developing new agents (attractants or repellents) for bed bug control.
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1992-10-01
intelligence developed an authentic European conflict scenario based on WINTEX- CIMEX , a detailed European command post exercise. One of the primary...them. The only exercises in which we effectively train from start to finish are the large CPXs like WINTEX/ CIMEX . This exercise is a procedural...general war CPX, sponsored by the Joint Chiefs of Staff. WINTEX/ CIMEX exercises. tests, and evaluates command and control procedures. planning. and
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Repellency of selected chemicals against the bed bug, (hemiptra: Cimicidae)
USDA-ARS?s Scientific Manuscript database
In recent years, the common bed bug, Cimex lectularius L. (Hemiptera: Cimicidae), became a major public health concern in urban communities. Bed bugs are notoriously difficult to control and their painful bites are not tolerated by most people. The public has a strong need for materials and methods ...
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[Lice, fleas and other beasts].
Hufnagel, Markus; Berner, Reinhard
2007-07-01
Bedbugs, lice, fleas and mites are blood-sucking ectoparasites whose bites cause allergic skin reactions. Diagnosis of bites is based on the morphology of the skin eruptions and the pattern of involved skin areas. Confirmation of the diagnosis often requires detection of the causal parasite. The main reservoir for ectoparasites (e.g., bedbugs, fleas, lice and scabies mites) are humans, but animals are also known to harbor ectoparasites (e.g., certain fleas and mites). Fleas, body lice and certain mite larvae in the tropics can transmit infectious diseases, but bedbugs, headlice, pubic lice and scabies mites cannot. Therapy is primarily directed against itching and bacterial superinfections. Pediculosis and scabies are additionally treated with t0pical insecticides. In order to kill freshly hatched larvae, topical treatmentmust be repeated after one week. In the case of pediculosis, people who have come into contact with symptomatic individuals also need to be treated, whereas with scabies, all contact persons must undergo treatment in order toprevent further transmission. Topicalinsecticides, in combination with anti-itch treatment, is usually sufficientto immediately relieve the symptoms and promote permanent healing of the skin lesions.
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1989-03-14
rehearsed for years particularly in the "Autumn Forge" large-scale maneuvers, as well as in the Europe-wide secret "Wintex- Cimex " command post exercises...Plans and Unemployment"] [Text] In the framework of the command post exercise "Wintex- Cimex ," NATO is at present exercising the alliance’s ability...command post exercise, "Win- tex- Cimex " began, which will last until 9 March and which tests the alliance’s ability to carry out a nuclear
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Flonicamid does not kill bed bugs nor inhibit their feeding after treatment
USDA-ARS?s Scientific Manuscript database
Flonicamid is a systemic pesticide that inhibits the feeding of certain greenhouse pest and certain hemipteran pests of agricultural crops. In a laboratory study directed at the common bed bug (Cimex lectularius L.), flonicamid was evaluated for its ability to either kill or inhibit the feeding of t...
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USDA-ARS?s Scientific Manuscript database
Bed bugs as pests of public health importance recently experienced a resurgence in populations throughout the U.S. and other countries. Consequently, recent research efforts have focused on improving understanding of bed bug physiology and behavior to improve management. While few studies have inves...
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1985-01-01
numerous major exercises, such as WINTEX- CIMEX , REFORGER, CRESTED EAGLE, and BRIGHT STAR. USAFE is now actively planning an evolutionary approach toward C2...during WINTEX- CIMEX 85, we have been investigating a number of approaches to enhancing joint air-ground operations and providing a means for better...throughout the ground battle elements. The USAREUR Distributed Decision Aid System (UD[1AS) was initially deployed in Exercise WINTEX- CIMEX 84. During
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Far Away from the Revolution: Understanding the Cuban Revolutionary Armed Forces Mission Changes
2011-12-01
municipalities), Plan for Entrepreneurial Redesign, CIMEX (import/export, free-trade zones, tourism, transportation, digital communications equipment, car...rentals and audiovisual publicity), CUBANA-CAN (similar to CIMEX ), Citrus (agricultural and industrial processing), State Commission for
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1979-11-01
FORGE REFORGER and CRESTED CAP NORTHERN WEDDING 78 DISPLAY DETERMINATION 78 WINTEX/ CIMEX 79 POWER PLAN 79 US Service Participation in Exercises...southern flank with the rapid employment of external reinforce- ments. WINTEX/ CIMEX 79- In the area of major command post exercises this exercise...planning for which is currently underway) Is of particular Interest. WINTEX/ CIMEX 79 is the latest In the WINTEX series of major NATO-wide command post
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Studies on Proteinases from Some Blood-Sucking Insects,
ovinus, and Pediculus humanus, but not in those of Cimex lectularius or Rhodnius prolixus. The trypsin and chymotrypsin have been partially... Cimex and Rhodnius appear to have a high molecular weight proteinase with optimal activity at pH 5 in their midguts. (Author)
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... use of synthetic chemical insecticides. Use Integrated Pest Management , which involves a combination of nonchemical strategies such as maintenance and sanitation followed by pesticides, if other methods ...
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NASA Astrophysics Data System (ADS)
Guerin, François; Dantes, Didier; Savaria, Eric; Selingardi, Mario Luis; Montes, Amauri Silva
2018-04-01
This paper, "CIMEX: a prototype Instrument to observe from space the amazon forest In the near and shortwave infrared," was presented as part of International Conference on Space Optics—ICSO 1997, held in Toulouse, France.
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Human Odorant Reception in the Common Bed Bug, Cimex lectularius.
Liu, Feng; Liu, Nannan
2015-11-02
The common bed bug Cimex lectularius is a temporary ectoparasite on humans and currently resurgent in many developed countries. The ability of bed bugs to detect human odorants in the environment is critical for their host-seeking behavior. This study deciphered the chemical basis of host detection by investigating the neuronal response of olfactory sensilla to 104 human odorants using single sensillum recording and characterized the electro-physiological responses of bed bug odorant receptors to human odorants with the Xenopus expression system. The results showed that the D type of olfactory sensilla play a predominant role in detecting the human odorants tested. Different human odorants elicited different neuronal responses with different firing frequencies and temporal dynamics. Particularly, aldehydes and alcohols are the most effective stimuli in triggering strong response while none of the carboxylic acids showed a strong stimulation. Functional characterization of two bed bug odorant receptors and co-receptors in response to human odorants revealed their specific responses to the aldehyde human odorants. Taken together, the findings of this study not only provide exciting new insights into the human odorant detection of bed bugs, but also offer valuable information for developing new reagents (attractants or repellents) for the bed bug control.
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Human Odorant Reception in the Common Bed Bug, Cimex lectularius
Liu, Feng; Liu, Nannan
2015-01-01
The common bed bug Cimex lectularius is a temporary ectoparasite on humans and currently resurgent in many developed countries. The ability of bed bugs to detect human odorants in the environment is critical for their host-seeking behavior. This study deciphered the chemical basis of host detection by investigating the neuronal response of olfactory sensilla to 104 human odorants using single sensillum recording and characterized the electro-physiological responses of bed bug odorant receptors to human odorants with the Xenopus expression system. The results showed that the D type of olfactory sensilla play a predominant role in detecting the human odorants tested. Different human odorants elicited different neuronal responses with different firing frequencies and temporal dynamics. Particularly, aldehydes and alcohols are the most effective stimuli in triggering strong response while none of the carboxylic acids showed a strong stimulation. Functional characterization of two bed bug odorant receptors and co-receptors in response to human odorants revealed their specific responses to the aldehyde human odorants. Taken together, the findings of this study not only provide exciting new insights into the human odorant detection of bed bugs, but also offer valuable information for developing new reagents (attractants or repellents) for the bed bug control. PMID:26522967
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Logistics Command and Control Task and Training Analysis
1991-01-01
documents for "Proud Eagle " and "Wintex/ Cimex ," (including the Remedial Action Project (RAP) items) and other documentation provided by the...middle of WINTEX/ CIMEX 89 and the preceding weeks. OJT was basic familiarization with terms and forms prescribed for use. F. Basically no - My initial
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Planning for the Mobilization of the Nation’s Medical Resources
1985-01-01
CIMEX 85, has yet to be approved by the Military Services or the DIMSB.1I A 1980 DOD report commented that although annual planning provides for WRMS... CIMEX 85 trial. Until such time as adequate WRMS is available, this type of program seems to offer the only means of assuring that those with the
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... Us Media contacts Advertising contacts AAD logo Advertising, marketing and sponsorships Legal notice Copyright © 2018 American Academy ... prohibited without prior written permission. AAD logo Advertising, marketing and sponsorships Legal notice Copyright © 2017 American Academy ...
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1988-06-01
conjunction with the NATO exercise Wintex- Cimex 83, in February 83. The Maritime Administration conducted a survey of facilities and tugboat availability, and...BREAKOUT-85 69 32 32 21 16 WINTEX- CIMEX 83 30 3 21 6 3 During this exercise, the Maritime Administration tasked its Eastern, Central and Western
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1990-03-13
and other damage to property "violence-free" called for "interference" actions against NATO’s headquarters exercise, Wintex- Cimex , in February 1987...military units; o disruptions of the Wintex/ Cimex exercises; o actions directed against exhibitions of the German Federal Armed Forces; o blockades and
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An Early Holocene Record of Cimex (Hemiptera: Cimicidae) From Western North America.
Adams, Martin E; Jenkins, Dennis L
2017-07-01
The subfossil remains of 14 cimicids (Hemiptera: Cimicidae) were recovered during archaeological investigations of the Paisley Five Mile Point Cave site (35LK3400), an exceptionally well-dated (n = 229 radiocarbon dates) late Pleistocene-early Holocene rock shelter site in south-central Oregon. Nine of the specimens have been assigned to three modern species of Nearctic Cimicidae-Cimex antennatus Usinger & Ueshima, Cimex latipennis Usinger & Ueshima, and Cimex pilosellus (Horváth)-whereas the remaining five individuals were too fragmentary to positively identify. The chronology of the insect assemblage puts one specimen at circa 5,100 calibrated years before present (cal. yr BP), and the remaining 13 range in age from 9,400 to almost 11,000 cal. yr BP. Although fossil and subfossil cimicid remains have been recovered at other archaeological sites, the fossil record for bed bugs is largely undocumented. The Paisley Caves specimens thus far represent the oldest remains of the genus in probable contact with humans on record. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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Reserve Component Special Forces Integration and Employment Models for the Operational Continuum
1992-04-15
OCONUS OPTEMPO CY87-90 1987 20 SFGA WINTEX/ CIMEX (NATO) HQ AFSOUTH 20 SFGA EX SCHWARZES PFERD FRG 1-20 SFGA (ODB+2 ODA) FTX SCHWARZES PFERD FRG (ODB+3...FTX TRABUCCO SPAIN 3-20 SFGA (2 ODA) FRENCH COMMANDO JCET MARTINIQUE (2 ODA) GERMAN AIRBORNE GERMANY 37 1-il SFGA FOB WINTEX/ CIMEX UK (ODB+4 ODA) EX
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Benoit, Joshua B.
2011-01-01
Recent emergence of bed bugs (Cimex spp.) has prompted a significant expansion of research devoted to this pest. The ability to survive and recover from stress has significant implications on the distribution and survival of insects, and bed bugs are no exception. Research on bed bug stress tolerance has shown considerable progress and necessitates a review on this topic. Bed bugs have an extraordinary ability to resist dehydration between bloodmeals, and this represents a critical factor allowing their prolonged survival when no host is available. High relative humidities are detrimental to bed bugs, leading to reduced survival in comparison to those held at lower relative humidities. Continual exposure of bed bugs, eggs and mobile stages, to temperatures below freezing and short term exposure (=1 h) to temperatures below −16 to −18 °C results in mortality. The upper thermal limit for short term exposure of eggs, nymphs and adults is between 40–45 °C for the common (Cimex lectularius) and tropical (C. hemipterus) bed bugs. Long-term exposure to temperatures above 35 °C results in significant reduction in survival of mobile bed bugs. Eggs for C. lectularius and C. hemipterus are no longer viable when held below 10 °C or above 37 °C throughout embryogenesis. Blood feeding, although necessary for survival and reproduction, is discussed as a stress due to thermal and osmotic fluctuations that result from ingesting a warm bloodmeal from a vertebrate host. Cold, heat, water stress and blood feeding prompted the expression of heat shock proteins (Hsps). Pesticide application is a common human-induced stress for urban pests, and recent studies have documented pesticide resistance in many bed bug populations. High levels of traumatic insemination (mating) of bed bugs has been linked to reduced survival and fecundity along with possibly exposing individuals to microbial infections after cuticular penetration by the paramere (=male reproductive organ), thus represents a form of sexual stress. Additionally, less common stress types such as microbial infections that have been documented in bed bugs will be discussed. Overall, this review provides a current update of research related to bed bug stress tolerance and how their ability to resist stressful conditions has lead to their expansion and proliferation. PMID:26467619
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1984-01-01
addressing the NATO WINTEX/ CIMEX -85 Exercise in order to bring into its major events oppor- tunities to test new modalities for civil-military cooperation...context. Perhaps the most effective means for assessing the implica- tions of such concerns lies in the exercise arena. The forthcoming WINTEX/ CIMEX -85
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Rupeš, V; Vlčková, J; Holý, O; Horáková, D; Azeem, K; Kollárová, H
2017-01-01
Bed bugs have become a major concern worldwide in the 21st century and are therefore intensively investigated. The new findings not only extend the knowledge of their biology, medical relevance, and causes of the resurgence, but also can be used in bed bug management. A brief overview is provided of some of the most important research results and opinions, published in the last few years in prestigious international journals.
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Applicator Training Manual for: Public Health Pest Control.
ERIC Educational Resources Information Center
Moore, E. E.
This manual gives the life cycle and habitats, public health importance, methods of non-chemical control, and pesticides and methods of application for mosquitoes, flies, bedbugs, fleas, lice, cockroaches, venomous anthropods, ticks and chiggers, and rodents. (BB)
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Liu, Feng; Xia, Xiaoming; Liu, Nannan
2017-01-01
As the most extensively used chemical repellent, N,N-diethyl-3-methylbenzamide (DEET) displayed repellency to a wide range of insects, including the common bed bug, Cimex lectularius . While the neuronal or molecular basis involved in DEET's repellency have been majorly focused on mosquitos and fruit flies, DEET's repellency to the common bed bug is largely unreached. To gain new insights into the cellular and molecular mechanisms in DEET's repellency to the common bed bug, we characterized the neuronal response of bed bugs to DEET, identified the olfactory receptors targeted by DEET and demonstrated the interfering effect of DEET on bed bug's responses to human odorants. High doses of DEET were required for activating the olfactory receptor neurons in the sensilla of bed bugs and at least three DEET-sensitive receptors were functionally deciphered. These DEET-sensitive receptors presented even more sensitive to certain botanical terpenes/terpenoids which also displayed repellency at varying levels for bed bugs. In addition, DEET produced a blocking effect on the neuronal responses of bed bugs to specific human odors and showed inhibitory effect on the function of odorant receptors in responding to certain human odors. Taken together, our results indicate that DEET may function as a stimulus that triggers avoidance behaviors and a molecular "confusant" for interrupting the host odor recognition in the odorant receptors of bed bugs. The receptors that coincidently responded to both synthetic DEET and botanical terpenes/terpenoids suggested that DEET probably target on receptors that originally responded to terpenes/terpenoids. This study gave novel insight into the mechanisms of DEET's repellency to bed bugs and also provided valuable information for developing new reagents for bed bug control.
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Liu, Feng; Xia, Xiaoming; Liu, Nannan
2017-01-01
As the most extensively used chemical repellent, N,N-diethyl-3-methylbenzamide (DEET) displayed repellency to a wide range of insects, including the common bed bug, Cimex lectularius. While the neuronal or molecular basis involved in DEET's repellency have been majorly focused on mosquitos and fruit flies, DEET's repellency to the common bed bug is largely unreached. To gain new insights into the cellular and molecular mechanisms in DEET's repellency to the common bed bug, we characterized the neuronal response of bed bugs to DEET, identified the olfactory receptors targeted by DEET and demonstrated the interfering effect of DEET on bed bug's responses to human odorants. High doses of DEET were required for activating the olfactory receptor neurons in the sensilla of bed bugs and at least three DEET-sensitive receptors were functionally deciphered. These DEET-sensitive receptors presented even more sensitive to certain botanical terpenes/terpenoids which also displayed repellency at varying levels for bed bugs. In addition, DEET produced a blocking effect on the neuronal responses of bed bugs to specific human odors and showed inhibitory effect on the function of odorant receptors in responding to certain human odors. Taken together, our results indicate that DEET may function as a stimulus that triggers avoidance behaviors and a molecular “confusant” for interrupting the host odor recognition in the odorant receptors of bed bugs. The receptors that coincidently responded to both synthetic DEET and botanical terpenes/terpenoids suggested that DEET probably target on receptors that originally responded to terpenes/terpenoids. This study gave novel insight into the mechanisms of DEET's repellency to bed bugs and also provided valuable information for developing new reagents for bed bug control. PMID:28676765
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Jourdain, Frédéric; Delaunay, Pascal; Bérenger, Jean-Michel; Perrin, Yvon; Robert, Vincent
2016-01-01
The Common bed bug, Cimex lectularius, had virtually disappeared from France in the 1950s; however, a worldwide resurgence of bed bugs (C. lectularius and C. hemipterus) has been observed since the 1990s. To document modern pest control activities for the management of bed bugs, a survey was conducted in metropolitan France among the two main categories of professionals regularly called upon to deal with the control of infestations: Municipal Health and Safety Services (MHSSs) and private Pest Management Companies (PMCs). These professionals responded to a questionnaire targeting their knowledge, attitude and practices related to the process for diagnosing a bed bug infestation and the processes taken to actually control an infestation. There were 68 responses received from MHSSs and 51 from the PMCs. The responses indicate that every single département (French administrative division) in metropolitan France has witnessed at least one intervention for bed bugs. Among the criteria considered sufficient to confirm a bed bug infestation, direct observation of bugs was the most commonly cited response. Faced with an infestation, most PMCs used a combination of non-chemical and chemical methods, and systematically performed two treatments. This survey is the first of professionals involved in bed bug control in metropolitan France and confirms the growing importance of bed bugs as a public health pest. Establishing a database to monitor this emerging pest would improve the understanding of the distribution of these insects, help guide educational requirements, identify research needs and assist in ensuring that the most appropriate control practices are undertaken. PMID:27605306
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Efficacy of three different steamers for control of bed bugs (Cimex lectularius L.).
Wang, Desen; Wang, Changlu; Wang, Guohong; Zha, Chen; Eiden, Amanda L; Cooper, Richard
2018-04-15
Bed bugs, Cimex lectularius L., have become one of the most difficult urban pests to control. Steam treatment is reported to be an effective method to kill bed bugs and is considered to be an important component of bed bug integrated pest management (IPM). We evaluated and compared the efficacy of two affordable consumer-grade commercial steamers to a commonly used professional-grade steamer for killing bed bugs. In laboratory experiments, the consumer-grade steamer at an affordable price achieved the same high control efficacy as the professional-grade steamer for treating bed bugs exposed on mattresses (100% bed bug mortality), located beneath a fabric cover (>89% bed bug mortality), or hiding in cracks (100% bed bug mortality). Bed bugs located behind a leather cover did not suffer significant mortality from steam treatment regardless of the type of steamers used and treatment duration. Proper use of steamers can kill all life stages of bed bugs. Affordable consumer-grade steamers are as effective as professional-grade steam machines for eliminating bed bugs resting on mattresses, hiding behind fabric materials, or in cracks. This article is protected by copyright. All rights reserved.
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Public Health Pest Control. Bulletin 755.
ERIC Educational Resources Information Center
Evans, Burton R.
This manual gives general control principles and specific information on control of mosquitoes, flies, bedbugs, fleas, lice, cockroaches, venomous arthropods, ticks and chiggers, and rodents. The specific information includes life-cycles and habitats, public health importance, non-chemical control, and control with pesticides. (BB)
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Public Health Pest Control Category Manual.
ERIC Educational Resources Information Center
Bowman, James S.; Turmel, Jon P.
This manual provides information needed to meet the standards for pesticide applicator certification. It presents pest control guidelines for those organisms of public health significance. Fact sheets with line drawings discuss pests such as cockroaches, bedbugs, lice, ants, beetles, bats, birds, and rodents. (CS)
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A Linkage Map and QTL Analysis for Pyrethroid Resistance in the Bed Bug Cimex lectularius
Fountain, Toby; Ravinet, Mark; Naylor, Richard; Reinhardt, Klaus; Butlin, Roger K.
2016-01-01
The rapid evolution of insecticide resistance remains one of the biggest challenges in the control of medically and economically important pests. Insects have evolved a diverse range of mechanisms to reduce the efficacy of the commonly used classes of insecticides, and finding the genetic basis of resistance is a major aid to management. In a previously unstudied population, we performed an F2 resistance mapping cross for the common bed bug, Cimex lectularius, for which insecticide resistance is increasingly widespread. Using 334 SNP markers obtained through RAD-sequencing, we constructed the first linkage map for the species, consisting of 14 putative linkage groups (LG), with a length of 407 cM and an average marker spacing of 1.3 cM. The linkage map was used to reassemble the recently published reference genome, facilitating refinement and validation of the current genome assembly. We detected a major QTL on LG12 associated with insecticide resistance, occurring in close proximity (1.2 Mb) to a carboxylesterase encoding candidate gene for pyrethroid resistance. This provides another example of this candidate gene playing a major role in determining survival in a bed bug population following pesticide resistance evolution. The recent availability of the bed bug genome, complete with a full list of potential candidate genes related to insecticide resistance, in addition to the linkage map generated here, provides an excellent resource for future research on the development and spread of insecticide resistance in this resurging pest species. PMID:27733453
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Lilly, David G.; Latham, Sharissa L.; Webb, Cameron E.; Doggett, Stephen L.
2016-01-01
Thickening of the integument as a mechanism of resistance to insecticides is a well recognised phenomenon in the insect world and, in recent times, has been found in insects exhibiting pyrethroid-resistance. Resistance to pyrethroid insecticides in the common bed bug, Cimex lectularius L., is widespread and has been frequently inferred as a reason for the pest’s resurgence. Overexpression of cuticle depositing proteins has been demonstrated in pyrethroid-resistant bed bugs although, to date, no morphological analysis of the cuticle has been undertaken in order to confirm a phenotypic link. This paper describes examination of the cuticle thickness of a highly pyrethroid-resistant field strain collected in Sydney, Australia, in response to time-to-knockdown upon forced exposure to a pyrethroid insecticide. Mean cuticle thickness was positively correlated to time-to-knockdown, with significant differences observed between bugs knocked-down at 2 hours, 4 hours, and those still unaffected at 24 hours. Further analysis also demonstrated that the 24 hours survivors possessed a statistically significantly thicker cuticle when compared to a pyrethroid-susceptible strain of C. lectularius. This study demonstrates that cuticle thickening is present within a pyrethroid-resistant strain of C. lectularius and that, even within a stable resistant strain, cuticle thickness will vary according to time-to-knockdown upon exposure to an insecticide. This response should thus be considered in future studies on the cuticle of insecticide-resistant bed bugs and, potentially, other insects. PMID:27073871
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Lilly, David G; Latham, Sharissa L; Webb, Cameron E; Doggett, Stephen L
2016-01-01
Thickening of the integument as a mechanism of resistance to insecticides is a well recognised phenomenon in the insect world and, in recent times, has been found in insects exhibiting pyrethroid-resistance. Resistance to pyrethroid insecticides in the common bed bug, Cimex lectularius L., is widespread and has been frequently inferred as a reason for the pest's resurgence. Overexpression of cuticle depositing proteins has been demonstrated in pyrethroid-resistant bed bugs although, to date, no morphological analysis of the cuticle has been undertaken in order to confirm a phenotypic link. This paper describes examination of the cuticle thickness of a highly pyrethroid-resistant field strain collected in Sydney, Australia, in response to time-to-knockdown upon forced exposure to a pyrethroid insecticide. Mean cuticle thickness was positively correlated to time-to-knockdown, with significant differences observed between bugs knocked-down at 2 hours, 4 hours, and those still unaffected at 24 hours. Further analysis also demonstrated that the 24 hours survivors possessed a statistically significantly thicker cuticle when compared to a pyrethroid-susceptible strain of C. lectularius. This study demonstrates that cuticle thickening is present within a pyrethroid-resistant strain of C. lectularius and that, even within a stable resistant strain, cuticle thickness will vary according to time-to-knockdown upon exposure to an insecticide. This response should thus be considered in future studies on the cuticle of insecticide-resistant bed bugs and, potentially, other insects.
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Chemoreception to aggregation pheromones in the common bed bug, Cimex lectularius.
Liu, Feng; Xiong, Caixing; Liu, Nannan
2017-03-01
The common bed bug, Cimex lectularius, is an obligate blood-feeding insect that is resurgent worldwide, posing a threat to human beings through its biting nuisance and disease transmission. Bed bug aggregation pheromone is considered a very promising attractant for use in the monitoring and management of bed bugs, but as yet little is known regarding the sensory physiology of bed bugs related to this pheromone. This study examined how the individual components of aggregation pheromone are perceived by the olfactory receptor neurons (ORNs) housed in different types of olfactory sensilla in bed bugs and the molecular basis for the ORNs' responses to the aggregation pheromone. We found that the ORNs in the D olfactory sensilla played a predominant role in detecting all the components of aggregation pheromone except for histamine, which was only recognized by the C sensilla. Bed bugs' E sensilla, which include four functionally distinct groups, showed only a very weak but variant sensitivity (both excitatory and inhibitory) to the components of aggregation pheromone. Functional tests of 15 odorant receptors (ORs) in response to the components of aggregation pheromone revealed that most of these components were encoded by multiple ORs with various tuning properties. This study provides a comprehensive understanding of how bed bug aggregation pheromone is perceived and recognized in the peripheral olfactory system and will contribute useful information to support the development of synthetic attractants for bed bug monitoring and control. Copyright © 2017 Elsevier Ltd. All rights reserved.
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Dang, Kai; Toi, Cheryl S; Lilly, David G; Bu, Wenjun; Doggett, Stephen L
2015-07-01
Pyrethroid resistance in the common bed bug, Cimex lectularius L., has been reported worldwide. An important resistance mechanism is via knockdown resistance (kdr) mutations, notably V419L and L925I. Information regarding this kdr-type resistance mechanism is unknown in Australia. This study aims to examine the status of kdr mutations in Australian C. lectularius strains. Several modern field-collected strains and museum-preserved reference collections of Australian C. lectularius were examined. Of the field strains (2007-2013), 96% had the known kdr mutations (L925I or both V419L/L925I). The 'Adelaide' strain (2013) and samples from the preserved reference collections (1994-2002) revealed no known kdr mutations. A novel mutation I936F was apparent in the insecticide-resistant 'Adelaide' strain, one strain from Perth (with L925I) and the majority of the reference collection specimens. The laboratory insecticide-resistant 'Sydney' strain showed a mixture of no kdr mutations (20%) and L925I (80%). The novel mutation I936F may be a kdr mutation but appeared to contribute less resistance to the pyrethroids than the V419L and L925I mutations. The detection of high frequencies of kdr mutations indicates that kdr-type resistance is widespread across Australia. Hence, there should be a reduced reliance on pyrethroid insecticides and an integrated management approach for the control of C. lectularius infestations. © 2014 Society of Chemical Industry.
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Peterson, Jennifer K; Salazar, Renzo; Castillo-Neyra, Ricardo; Borrini-Mayori, Katty; Condori, Carlos; Bartow-McKenney, Casey; Tracy, Dylan; Náquira, César; Levy, Michael Z
2018-03-01
Although not presently implicated as a vector of human pathogens, the common bed bug, Cimex lectularius , has been suspected of carrying human pathogens because of its close association with humans and its obligate hematophagy. Recently, we characterized the vectorial competence of C. lectularius for the parasite Trypanosoma cruzi , the causative agent of Chagas disease. We observed that C. lectularius can acquire T. cruzi infection when fed on T. cruzi -carrying mice, and subsequently transmit T. cruzi to uninfected mice. This led us to ask why has C. lectularius not been implicated in the transmission of T. cruzi outside of the laboratory? We hypothesized that T. cruzi reduces C. lectularius fitness (i.e., survival and/or reproduction) as an explanation for why C. lectularius does not to transmit T. cruzi in natural settings. We tested this hypothesis by comparing the survival and reproduction of uninfected and T. cruzi -infected C. lectularius . We observed that T. cruzi had a variable effect on C. lectularius survival and reproduction. There were negligible differences between treatments in juveniles. Infected adult females tended to live longer and produce more eggs. However, no effect was consistent, and infected bugs showed more variation in survival and reproduction metrics than control bugs. We did not observe any negative effects of T. cruzi infection on C. lectularius survival or reproduction, suggesting that decreased fitness in T. cruzi -infected C. lectularius is not why bed bugs have not been observed to transmit T. cruzi in natural settings.
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Commercial Pesticides Applicator Manual: Public Health.
ERIC Educational Resources Information Center
Fitzwater, William D.; Reed, Leonard G., Jr.
This training manual provides information needed to meet the minimum EPA standards for certification as a commercial applicator of pesticides in the public health pest control category. The text discusses pests such as roaches, bedbugs, bees, mosquitoes, gnats, flies, and rodents with possible control measures provided. (CS)
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Jourdain, Frédéric; Delaunay, Pascal; Bérenger, Jean-Michel; Perrin, Yvon; Robert, Vincent
2016-01-01
The Common bed bug, Cimex lectularius, had virtually disappeared from France in the 1950s; however, a worldwide resurgence of bed bugs (C. lectularius and C. hemipterus) has been observed since the 1990s. To document modern pest control activities for the management of bed bugs, a survey was conducted in metropolitan France among the two main categories of professionals regularly called upon to deal with the control of infestations: Municipal Health and Safety Services (MHSSs) and private Pest Management Companies (PMCs). These professionals responded to a questionnaire targeting their knowledge, attitude and practices related to the process for diagnosing a bed bug infestation and the processes taken to actually control an infestation. There were 68 responses received from MHSSs and 51 from the PMCs. The responses indicate that every single département (French administrative division) in metropolitan France has witnessed at least one intervention for bed bugs. Among the criteria considered sufficient to confirm a bed bug infestation, direct observation of bugs was the most commonly cited response. Faced with an infestation, most PMCs used a combination of non-chemical and chemical methods, and systematically performed two treatments. This survey is the first of professionals involved in bed bug control in metropolitan France and confirms the growing importance of bed bugs as a public health pest. Establishing a database to monitor this emerging pest would improve the understanding of the distribution of these insects, help guide educational requirements, identify research needs and assist in ensuring that the most appropriate control practices are undertaken. © F. Jourdain et al., published by EDP Sciences, 2016.
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... Staying Safe Videos for Educators Search English Español Hey! A Flea Bit Me! KidsHealth / For Kids / Hey! A Flea Bit Me! Print en español ¡Ay! ¡ ... 30% DEET. More on this topic for: Kids Hey! A Gnat Bit Me! Hey! A Bedbug Bit ...
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REINHARDT, K.; WONG, C. H.; GEORGIOU, A. S.
2008-01-01
SUMMARY The global increase of the human parasite, the common bed bug Cimex lectularius, calls for specific pest control target sites. The bed bug is also a model species for sexual conflict theory which suggests seminal fluids may be highly diverse. The species has a highly unusual sperm biology and seminal proteins may have unique functions. 1-D PAGE gels showed 40 to 50% band sharing between C. lectularius and another cimicid species, Afrocimex constrictus. However, adult, sexually rested C. lectularius males were found to store 5 to 7μg of seminal protein and with only 60μg of protein we obtained informative 2-D PAGE gels. These showed 79% shared protein spots between two laboratory populations, and more than half of the shared protein spots were detected in the mated female. Further analysis using liquid chromatography electrospray ionisation tandem mass spectrometry revealed that 26.5% of the proteins had matches among arthropods in data bases and 14.5% matched Drosophila proteins. These included ubiquitous proteins but also those more closely associated with reproduction such as moj 29, ubiquitin, the stress-related elongation factor EF-1alpha, a protein disulfide isomerase and an antioxidant, Peroxiredoxin 6. PMID:19091156
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Meriweather, Matthew; Matthews, Sara; Rio, Rita; Baucom, Regina S.
2013-01-01
Elucidating the spatial dynamic and core constituents of the microbial communities found in association with arthropod hosts is of crucial importance for insects that may vector human or agricultural pathogens. The hematophagous Cimex lectularius (Hemiptera: Cimicidae), known as the human bed bug, has made a recent resurgence in North America, as well as worldwide, potentially owing to increased travel, climate change and resistance to insecticides. A comprehensive survey of the bed bug microbiome has not been performed to date, nor has an assessment of the spatial dynamics of its microbiome. Here we present a survey of internal and external bed bug microbial communities by amplifying the V4–V6 hypervariable region of the 16S rDNA gene region followed by 454 Titanium sequencing using 31 individuals from eight distinct collection locations obtained from residences in Cincinnati, OH. Across all samples, 97% of the microbial community is made up of two dominant OTUs, previously identified as the α-proteobacterium Wolbachia and an unnamed γ-proteobacterium from the Enterobacteriaceae. Microbial communities varied among host locations for measures of community diversity and exhibited structure according to collection location. This broad survey represents the most in-depth assessment, to date, of the microbes that associate with bed bugs. PMID:23585900
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Sierras, Angela; Schal, Coby
2016-01-01
Background The global prevalence of Cimex lectularius infestations has challenged current intervention efforts, as pyrethroid resistance has become ubiquitous, availability of labeled insecticides for bed bugs is limited, and non-chemical treatment options, such as heat, are often unaffordable. We evaluated representative insecticides toward the goal of developing a novel, ingestible liquid bait for hematophagous arthropods. Results LC50 values were estimated for adult males and first instar nymphs of an insecticide-susceptible strain for abamectin, clothianidin, fipronil and indoxacarb, after ingestion from an in vitro feeder. LD50 values were calculated based on the ingested blood volume. Ingested abamectin, clothianidin and fipronil caused rapid mortality in both life stages. Fipronil was ∼43-fold more effective by ingestion than by topical application. Indoxacarb and its bioactive metabolite decarbomethoxyllated JW062 (DCJW) were ineffective at causing bed bug mortality even at concentrations as high as 1000 ng mL−1 blood. Conclusions Fipronil, clothianidin and abamectin have potential for being incorporated into a liquid bait for bed bug control; indoxacarb and DCJW were not effective. Bed bugs are a good candidate for an ingestible liquid bait because systemic formulations generally require less active ingredient than residual sprays, they remain contained and more effectively target hematophagous arthropods. PMID:27766740
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Meriweather, Matthew; Matthews, Sara; Rio, Rita; Baucom, Regina S
2013-01-01
Elucidating the spatial dynamic and core constituents of the microbial communities found in association with arthropod hosts is of crucial importance for insects that may vector human or agricultural pathogens. The hematophagous Cimex lectularius (Hemiptera: Cimicidae), known as the human bed bug, has made a recent resurgence in North America, as well as worldwide, potentially owing to increased travel, climate change and resistance to insecticides. A comprehensive survey of the bed bug microbiome has not been performed to date, nor has an assessment of the spatial dynamics of its microbiome. Here we present a survey of internal and external bed bug microbial communities by amplifying the V4-V6 hypervariable region of the 16S rDNA gene region followed by 454 Titanium sequencing using 31 individuals from eight distinct collection locations obtained from residences in Cincinnati, OH. Across all samples, 97% of the microbial community is made up of two dominant OTUs, previously identified as the α-proteobacterium Wolbachia and an unnamed γ-proteobacterium from the Enterobacteriaceae. Microbial communities varied among host locations for measures of community diversity and exhibited structure according to collection location. This broad survey represents the most in-depth assessment, to date, of the microbes that associate with bed bugs.
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Campbell, Brittany E; Miller, Dini M
2015-01-15
Two strains of the common bed bug, Cimex lectularius L., eggs and first instars collected from pyrethroid-resistant adults were evaluated for insecticide resistance and compared to a susceptible strain. Dose-response bioassays were conducted using two insecticide formulations (Temprid: imidacloprid/β-cyfluthrin, and Transport: acetamiprid/ bifenthrin). The lethal concentration (LC50) for the two resistant egg strains exposed to imidacloprid/β-cyfluthrin ranged from 3 to 5-fold higher than susceptible strain eggs. Resistant strain eggs dipped into formulations of acetamiprid/bifenthrin had LC50 values which were significantly greater (39 to 1,080-fold) than susceptible strain eggs. Similar to eggs, resistant strain first instars exposed to residual applications of imidacloprid/β-cyfluthrin had LC50 values ranging from 121 to 493-fold greater than susceptible strain first instars. When resistant strain first instars were treated with acetamiprid/bifenthrin, they had LC50 values that were 99 to >1,900-fold greater than susceptible strain first instars. To determine differences between egg and first instar resistance, stage resistance ratios (SRR) were compared between the two stages. There was little difference between the egg and first instar stages, indicated by small SRR values ranging from 1.1 to 10.0. This study suggests that insecticide resistance is expressed early during bed bug development.
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Sierras, Angela; Schal, Coby
2017-03-01
The global prevalence of Cimex lectularius infestations has challenged current intervention efforts, as pyrethroid resistance has become ubiquitous, availability of labeled insecticides for bed bugs is limited, and non-chemical treatment options, such as heat, are often unaffordable. We evaluated representative insecticides toward the goal of developing a novel, ingestible liquid bait for hematophagous arthropods. LC 50 values were estimated for adult males and first instar nymphs of an insecticide-susceptible strain for abamectin, clothianidin, fipronil and indoxacarb, after ingestion from an artificial feeder. LD 50 values were calculated based on the ingested blood volume. Ingested abamectin, clothianidin and fipronil caused rapid mortality in both life stages. Fipronil was ∼43-fold more effective by ingestion than by topical application. Indoxacarb and its bioactive metabolite decarbomethoxylated JW062 (DCJW) were ineffective at causing bed bug mortality even at concentrations as high as 1000 ng mL -1 blood. Fipronil, clothianidin and abamectin have potential for being incorporated into a liquid bait for bed bug control; indoxacarb and DCJW were not effective. Bed bugs are a good candidate for an ingestible liquid bait because systemic formulations generally require less active ingredient than residual sprays, they remain contained and more effectively target hematophagous arthropods. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.
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Virulence of entomopathogenic bacteria in the bed bug, Cimex lectularius.
Pietri, Jose E; Liang, Dangsheng
2018-01-01
Due in part to the development of insecticide resistance, the common bed bug, Cimex lectularius, has overcome human intervention efforts to make a global resurgence. The failure of chemical pesticides has created a need for novel strategies to combat bed bugs. While a number of insect pests are susceptible to the use of entomopathogenic microbes or microbial-derived toxins, biological control methods have not been thoroughly explored in bed bugs. Here, we tested the virulence of three entomopathogenic bacterial species in C. lectularius to determine their potential for bed bug control. We examined bed bug survival after inoculation with live or heat-killed Serratia marcescens, Pseudomonas fluorescens, and Bacillus thuringiensis israelensis at varying temperatures. We also analyzed the viability and growth of the same bacteria in infected bed bugs. All three bacterial species were pathogenic to bed bugs. However, the effects of S. marcescens and P. fluorescens were temperature-dependent while the lethality of B. thuringiensis israelensis was not. In addition, bacterial virulence was partly dependent on the route of infection but was not strongly associated with proliferation. Thus, our results suggest multiple possible mechanisms of microbial pathogenicity in the bed bug and indicate that entomopathogenic bacteria, or products derived from them, may have useful applications for bed bug control. Copyright © 2017 Elsevier Inc. All rights reserved.
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Campbell, Brittany E.; Miller, Dini M.
2015-01-01
Two strains of the common bed bug, Cimex lectularius L., eggs and first instars collected from pyrethroid-resistant adults were evaluated for insecticide resistance and compared to a susceptible strain. Dose-response bioassays were conducted using two insecticide formulations (Temprid: imidacloprid/β-cyfluthrin, and Transport: acetamiprid/bifenthrin). The lethal concentration (LC50) for the two resistant egg strains exposed to imidacloprid/β-cyfluthrin ranged from 3 to 5-fold higher than susceptible strain eggs. Resistant strain eggs dipped into formulations of acetamiprid/bifenthrin had LC50 values which were significantly greater (39 to 1,080-fold) than susceptible strain eggs. Similar to eggs, resistant strain first instars exposed to residual applications of imidacloprid/β-cyfluthrin had LC50 values ranging from 121 to 493-fold greater than susceptible strain first instars. When resistant strain first instars were treated with acetamiprid/bifenthrin, they had LC50 values that were 99 to >1,900-fold greater than susceptible strain first instars. To determine differences between egg and first instar resistance, stage resistance ratios (SRR) were compared between the two stages. There was little difference between the egg and first instar stages, indicated by small SRR values ranging from 1.1 to 10.0. This study suggests that insecticide resistance is expressed early during bed bug development. PMID:26463070
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Human-facilitated metapopulation dynamics in an emerging pest species, Cimex lectularius
FOUNTAIN, TOBY; DUVAUX, LUDOVIC; HORSBURGH, GAVIN; REINHARDT, KLAUS; BUTLIN, ROGER K
2014-01-01
The number and demographic history of colonists can have dramatic consequences for the way in which genetic diversity is distributed and maintained in a metapopulation. The bed bug (Cimex lectularius) is a re-emerging pest species whose close association with humans has led to frequent local extinction and colonization, that is, to metapopulation dynamics. Pest control limits the lifespan of subpopulations, causing frequent local extinctions, and human-facilitated dispersal allows the colonization of empty patches. Founder events often result in drastic reductions in diversity and an increased influence of genetic drift. Coupled with restricted migration, this can lead to rapid population differentiation. We therefore predicted strong population structuring. Here, using 21 newly characterized microsatellite markers and approximate Bayesian computation (ABC), we investigate simplified versions of two classical models of metapopulation dynamics, in a coalescent framework, to estimate the number and genetic composition of founders in the common bed bug. We found very limited diversity within infestations but high degrees of structuring across the city of London, with extreme levels of genetic differentiation between infestations (FST = 0.59). ABC results suggest a common origin of all founders of a given subpopulation and that the numbers of colonists were low, implying that even a single mated female is enough to found a new infestation successfully. These patterns of colonization are close to the predictions of the propagule pool model, where all founders originate from the same parental infestation. These results show that aspects of metapopulation dynamics can be captured in simple models and provide insights that are valuable for the future targeted control of bed bug infestations. PMID:24446663
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Weeks, E N I; Logan, J G; Gezan, S A; Woodcock, C M; Birkett, M A; Pickett, J A; Cameron, M M
2011-02-01
The common bed bug, Cimex lectularius (Hemiptera: Cimicidae), has recently re-emerged in increasing numbers, distribution and intensity of infestation in many countries. Current control relies on the application of residual pesticides; but, due to the development of insecticide resistance, there is a need for new tools and techniques. Semiochemicals (behaviour and physiology modifying chemicals) could be exploited for management of bed bugs. However, in order to identify semiochemicals that can be utilised in monitoring or control, a suitable olfactometer is needed that enables the study of the responses of bed bugs to volatile chemicals. Previous studies have used olfactometers that do not separate olfactory responses from responses to physical contact. In this study, a still-air olfactometer was used to measure behavioural responses to different bed bug-derived volatiles presented in an odour pot. Bed bugs were significantly more likely to visit the area above the odour pot first, and more frequently, in the presence of volatiles from bed bug-exposed paper but not in the presence of volatiles from conspecific bed bugs. Bed bug activity was found to be dependent on the presence of the volatiles from bed bug-exposed paper, the time during the scotophase and the sex of the insect being tested. The still-air olfactometer could be used to test putative semiochemicals, which would allow an understanding of their behavioural role in bed bug ecology. Ultimately, this could lead to the identification of new semiochemical tools for bed bug monitoring and control.
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A Linkage Map and QTL Analysis for Pyrethroid Resistance in the Bed Bug Cimex lectularius.
Fountain, Toby; Ravinet, Mark; Naylor, Richard; Reinhardt, Klaus; Butlin, Roger K
2016-12-07
The rapid evolution of insecticide resistance remains one of the biggest challenges in the control of medically and economically important pests. Insects have evolved a diverse range of mechanisms to reduce the efficacy of the commonly used classes of insecticides, and finding the genetic basis of resistance is a major aid to management. In a previously unstudied population, we performed an F 2 resistance mapping cross for the common bed bug, Cimex lectularius, for which insecticide resistance is increasingly widespread. Using 334 SNP markers obtained through RAD-sequencing, we constructed the first linkage map for the species, consisting of 14 putative linkage groups (LG), with a length of 407 cM and an average marker spacing of 1.3 cM. The linkage map was used to reassemble the recently published reference genome, facilitating refinement and validation of the current genome assembly. We detected a major QTL on LG12 associated with insecticide resistance, occurring in close proximity (1.2 Mb) to a carboxylesterase encoding candidate gene for pyrethroid resistance. This provides another example of this candidate gene playing a major role in determining survival in a bed bug population following pesticide resistance evolution. The recent availability of the bed bug genome, complete with a full list of potential candidate genes related to insecticide resistance, in addition to the linkage map generated here, provides an excellent resource for future research on the development and spread of insecticide resistance in this resurging pest species. Copyright © 2016 Fountain et al.
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Zha, Chen; Wang, Changlu; Li, Andrew
2018-02-09
The common bed bug [Cimex lectularius L. (Hemiptera: Cimicidae)] and tropical bed bug [Cimex hemipterus F. (Hemiptera: Cimicidae)] resurged in the United States and many other countries over the past decades. The need for safe and effective bed bug control products propelled the development of numerous 'green insecticides', mostly with essential oils listed as active ingredients. Various inorganic and organic oils also were used for bed bug management. However, there are no published studies on their toxicities against bed bugs. In this study, we screened 18 essential oils, three silicone oils, and paraffin oil (C5-20 paraffins) for their toxicities against bed bugs. All the oils exhibited insecticidal activity in topical assays. Their toxicities varied significantly; all of the evaluated essential oils were less effective than silicone oils and paraffin oil. The LD50 values of the most effective essential oil (blood orange), paraffin oil, and the most effective silicone oil (dodecamethylpentasiloxane) are 0.184 ± 0.018, 0.069 ± 0.012, and 0.036 ± 0.005 mg per bug, respectively. Direct spray of 1% water solution of 3-[hydroxy (polyethyleneoxy) propyl] heptamethyltrisiloxane, the only silicone oil that mixes well with water, resulted in 92% bed bug mortality after 1 d. Results of this study indicate silicone oils and paraffin oil have the potential to be used as safer alternative bed bug control materials. © The Author(s) 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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ERIC Educational Resources Information Center
Christensen, Christian M.; Scheibner, R. A.
This manual gives descriptions and diagrams for identification of the following types of pests: four species of cockroach; ants; bees and wasps; parasitic pests of man such as bedbugs, fleas, and ticks; occasional invaders such as flies and millipedes; silverfish and firebrats; beetles; termites; moths; fungi; and vertebrates including rodents,…
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Goodman, Mark H; Potter, Michael F; Haynes, Kenneth F
2013-02-01
Bed bugs (Cimex lectularius L.) have become a common insect pest in urban areas and are often difficult to manage. Eradication is made more problematic by widespread insecticide resistance, raising interest in alternative control products. Juvenile hormone analogs (JHAs) such as methoprene and hydroprene are relatively harmless to non-arthropods and have proved to be effective against other urban insect pests. Two JHA products (Gentrol(®) and Precor(®), Central Life Sciences, Schaumburg, IL) were tested for efficacy against various bed bug stages as direct spray and as dry residue using three bed bug strains. At 1× and 2× the label rate, Precor(®) [active ingredient (S)-methoprene] had no significant effect on the development or fecundity of bed bugs. At 2× the label rate, confinement to residues of Gentrol(®) [active ingredient (S)-hydroprene] had no significant effect, but residues at 3× and 10× the label rate caused a reduction in fecundity and impaired development. Field strains were more susceptible to the reproductive effects of (S)-hydroprene than a long-maintained laboratory strain. While JHAs are attractive alternatives for pest management because of their inherent safety and distinct mode of action, these JHA formulations would have little impact on bed bug populations without relabeling to allow for higher application rates. Copyright © 2012 Society of Chemical Industry.
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Weeks, Emma N I; Birkett, Mike A; Cameron, Mary M; Pickett, John A; Logan, James G
2011-01-01
The recent resurgence of the common bed bug, Cimex lectularius L., has driven an increase in research into the biology and behaviour of this pest. Current control is reliant on the application of insecticides, but, owing to the development of insecticide resistance, there is a need for new tools and techniques. Semiochemicals (behaviour- and physiology-modifying chemicals) could be exploited for management of bed bugs. The aim of this review was to evaluate studies undertaken in bed bug chemical ecology to date, with particular reference to how the research could be exploited for monitoring and control. Bed bugs, like many other insects, have a complex olfactory system. Recent studies have characterised the olfactory sensilla, located on the terminal segment of the antennae, to functional classes by electrophysiological screening. Behavioural studies have revealed the presence of an alarm pheromone and potential airborne aggregation semiochemicals, but it is not yet understood if bed bugs use a sex pheromone during mating. Host location cues have been investigated, and carbon dioxide has been found to be highly attractive both in laboratory and in field studies. Recent field trials have tested blends of other potential kairomones, which have been shown to have an additive effect when used in a heated bed bug trap with carbon dioxide. The trap, which combines heat and kairomones, is the only trap currently available with proven efficacy in the field. In order for semiochemicals to be useful for bed bug management, an increased knowledge and understanding of the biology, behaviour and chemical ecology of this insect is essential. Copyright © 2010 Society of Chemical Industry.
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2010-01-01
Background Abdominal wounding by traumatic insemination and the lack of a long distance attraction pheromone set the scene for unusual sexual signalling systems. Male bed bugs (Cimex lectularius) mount any large, newly fed individual in an attempt to mate. Last instar nymphs overlap in size with mature females, which make them a potential target for interested males. However, nymphs lack the female's specific mating adaptations and may be severely injured by the abdominal wounding. We, therefore, hypothesized that nymphs emit chemical deterrents that act as an honest status signal, which prevents nymph sexual harassment and indirectly reduces energy costs for males. Results Behavioural mating assays showed that males mount nymphs significantly shorter time compared to females, although initial mounting preference was the same. In support of our hypothesis, nymphs experienced the same percentage of mating with sperm transfer as females if they were unable to emit (E)-2-hexenal, (E)-2-octenal 4-oxo-(E)-2-hexenal and 4-oxo-(E)-2-octenal, from their dorsal abdominal glands. We report that the aldehydes and 4-oxo-(E)-2-hexenal are detected by olfactory receptor neurons housed in smooth and grooved peg sensilla, respectively, on the adult antennae, at biologically relevant concentrations. Behavioural experiments showed that application of 4-oxo-(E)-2-hexenal or the two aldehydes at a nymph-emitted ratio, to a male/female pair during mounting initiation, decreased mating frequency to a rate comparable to that of a male/nymph pair. Conclusions By combining behavioural and sensory studies, we show that the nymph-specific alarm pheromone plays an important role in intra-specific communication in the common bed bug. Alarm pheromones are commonly looked upon as a system in predator/prey communication, but here we show that alarm pheromones may be used as multipurpose signals such as decreasing the risk of nymphal mating by males. See commentary: http://www.biomedcentral.com/1741-7007/8/117 PMID:20828381
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Insecticide resistance and resistance mechanisms in bed bugs, Cimex spp. (Hemiptera: Cimicidae).
Dang, Kai; Doggett, Stephen L; Veera Singham, G; Lee, Chow-Yang
2017-06-29
The worldwide resurgence of bed bugs [both Cimex lectularius L. and Cimex hemipterus (F.)] over the past two decades is believed in large part to be due to the development of insecticide resistance. The transcriptomic and genomic studies since 2010, as well as morphological, biochemical and behavioral studies, have helped insecticide resistance research on bed bugs. Multiple resistance mechanisms, including penetration resistance through thickening or remodelling of the cuticle, metabolic resistance by increased activities of detoxification enzymes (e.g. cytochrome P450 monooxygenases and esterases), and knockdown resistance by kdr mutations, have been experimentally identified as conferring insecticide resistance in bed bugs. Other candidate resistance mechanisms, including behavioral resistance, some types of physiological resistance (e.g. increasing activities of esterases by point mutations, glutathione S-transferase, target site insensitivity including altered AChEs, GABA receptor insensitivity and altered nAChRs), symbiont-mediated resistance and other potential, yet undiscovered mechanisms may exist. This article reviews recent studies of resistance mechanisms and the genes governing insecticide resistance, potential candidate resistance mechanisms, and methods of monitoring insecticide resistance in bed bugs. This article provides an insight into the knowledge essential for the development of both insecticide resistance management (IRM) and integrated pest management (IPM) strategies for successful bed bug management.
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Outbreeding effects in an inbreeding insect, Cimex lectularius.
Fountain, Toby; Butlin, Roger K; Reinhardt, Klaus; Otti, Oliver
2015-01-01
In some species, populations with few founding individuals can be resilient to extreme inbreeding. Inbreeding seems to be the norm in the common bed bug, Cimex lectularius, a flightless insect that, nevertheless, can reach large deme sizes and persist successfully. However, bed bugs can also be dispersed passively by humans, exposing inbred populations to gene flow from genetically distant populations. The introduction of genetic variation through this outbreeding could lead to increased fitness (heterosis) or be costly by causing a loss of local adaptation or exposing genetic incompatibility between populations (outbreeding depression). Here, we addressed how inbreeding within demes and outbreeding between distant populations impact fitness over two generations in this re-emerging public health pest. We compared fitness traits of families that were inbred (mimicking reproduction following a founder event) or outbred (mimicking reproduction following a gene flow event). We found that outbreeding led to increased starvation resistance compared to inbred families, but this benefit was lost after two generations of outbreeding. No other fitness benefits of outbreeding were observed in either generation, including no differences in fecundity between the two treatments. Resilience to inbreeding is likely to result from the history of small founder events in the bed bug. Outbreeding benefits may only be detectable under stress and when heterozygosity is maximized without disruption of coadaptation. We discuss the consequences of these results both in terms of inbreeding and outbreeding in populations with genetic and spatial structuring, as well as for the recent resurgence of bed bug populations.
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Wang, Changlu; Singh, Narinderpal; Cooper, Richard
2014-11-05
Bed bugs (Cimex lectularius L. and Cimex hemipterus F.) are among the most difficult urban pests to manage. Many essential oil-based bed bug control products that are considered reduced risk to mammals compared to synthetic insect neurotoxins have become commercially available, but their effectiveness as a stand-alone control method is unknown. This study assessed the field efficacy of an essential oil-based bed bug control product (EcoRaider; a.i. 1% geraniol + 1% cedar oil + 2% sodium lauryl sulfate) compared to a pyrethroid and neonicotinoid mixture spray (0.075% Temprid SC; a.i. beta-cyfluthrin + imidacloprid). After 12 weeks, the three treatments-EcoRaider, Temprid SC, and EcoRaider + Temprid SC caused 92.5 ± 2.7, 92.9 ± 3.0, and 91.7% ± 2.7% bed bug count reduction, respectively. No significant differences existed in the bed bug reduction among the treatments. Bed bugs were eliminated from only 22% of the treated apartments. Among those still with bed bugs, 76% of the residents did not know bed bugs were present. We documented the residents' self-control practices and discussed the potential of using essential oil-based insecticides in bed bug management programs to minimize the health risks to building occupants and pets and to slow down the development of insecticide resistance.
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Wang, Changlu; Singh, Narinderpal; Cooper, Richard
2014-01-01
Bed bugs (Cimex lectularius L. and Cimex hemipterus F.) are among the most difficult urban pests to manage. Many essential oil-based bed bug control products that are considered reduced risk to mammals compared to synthetic insect neurotoxins have become commercially available, but their effectiveness as a stand-alone control method is unknown. This study assessed the field efficacy of an essential oil-based bed bug control product (EcoRaider; a.i. 1% geraniol + 1% cedar oil + 2% sodium lauryl sulfate) compared to a pyrethroid and neonicotinoid mixture spray (0.075% Temprid SC; a.i. beta-cyfluthrin + imidacloprid). After 12 weeks, the three treatments—EcoRaider, Temprid SC, and EcoRaider + Temprid SC caused 92.5 ± 2.7, 92.9 ± 3.0, and 91.7% ± 2.7% bed bug count reduction, respectively. No significant differences existed in the bed bug reduction among the treatments. Bed bugs were eliminated from only 22% of the treated apartments. Among those still with bed bugs, 76% of the residents did not know bed bugs were present. We documented the residents’ self-control practices and discussed the potential of using essential oil-based insecticides in bed bug management programs to minimize the health risks to building occupants and pets and to slow down the development of insecticide resistance. PMID:26462944
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The Genera Coxiella, Wolbachia, and Rickettsiella,
1992-01-01
such as sero-diag- are body lice. bedbugs, fleas. and meal -vorm nosis: and 2) biosafetv level 3 practices and a- larvae. all of which support...insects, such ported its cultivation on blood-giucose-bouillon as mosquitoes of the Aedes scuiel/aris group agar . on which colonies 0.4 to ,. mm r. di...of the meals worm. Tenebrio mlofpteivthrogutrybhir molitor, in Germany (Krieg, 1955. 1965) and ample of protective thermoregulatory behavior several
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Politi, Flávio Augusto Sanches; Nascimento, Juliana Damieli; da Silva, Alexander Alves; Moro, Isabela Jacob; Garcia, Mariana Lopes; Guido, Rafael Victório Carvalho; Pietro, Rosemeire Cristina Linhari Rodrigues; Godinho, Antônio Francisco; Furlan, Maysa
2017-01-01
Emerging resistance to insecticides has influenced pharmaceutical research and the search for alternatives to control the common bed bug Cimex lectularius. In this sense, natural products can play a major role. Tagetes patula, popularly known as dwarf marigold, is a plant native to North America with biocide potential. The aim of this work was to evaluate the biological activity of T. patula essential oil (EO) against adult common bed bugs via exposure to dry residues by the Impregnated Paper Disk Test (IPDT) using cypermethrin as a positive control. We selected the enzyme acetylcholinesterase as a target for modeling studies, with the intent of investigating the molecular basis of any biological activity of the EO. Chemical analysis of the EO was performed using gas chromatography coupled to mass spectrometry (GC-MS). Additionally, oral and dermal acute toxicity tests were performed according to Organization for Economic Cooperation and Development (OECD) guidelines. The sulforhodamine B assay (SRB) was performed to verify the cytotoxicity of EO to HaCaT cells. The EO eliminated 100 % of the bed bugs at 100 mg mL -1 with an LC 50 value of 15.85 mg mL -1 . GC-MS analysis identified α-terpinolene, limonene, piperitenone, and piperitone as major components of the mixture. Molecular modeling studies of these major compounds suggested that they are acetylcholinesterase inhibitors with good steric and electronic complementarity. The in vitro cytotoxicity evaluation revealed a LC 50 = 37.06 μg mL -1 and in vivo acute toxicity showed an LC 50 >4000 mg kg -1 , indicating that the EO presents low risk of toxic side effects in humans. The T. patula essential oil components provide a promising strategy for controlling bed bug populations with low mammalian toxicity. These findings pave the way for further in vivo studies aimed at developing a safe and effective insecticide.
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... Consultations, and General Public. Contact Us Parasites Home Bed Bugs FAQs Recommend on Facebook Tweet Share Compartir On ... are bed bugs treated and prevented? What are bed bugs? Bed bugs ( Cimex lectularius ) are small, flat, parasitic ...
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Weeks, E N I; Logan, J G; Birkett, M A; Pickett, J A; Cameron, M M
2013-02-01
The common bed bug, Cimex lectularius, feeds on the blood of mammal and bird hosts, and is a pest of global importance. Semiochemicals are chemicals involved in animal communication that may affect behaviour and/or physiology. Attractive semiochemicals that play a role in mediating bed bug behaviour could be exploited for the development of a highly effective novel monitoring device. Tracking software was used to record the response of bed bugs to volatiles from paper previously exposed to conspecific bugs in a still-air olfactometer illuminated by infrared lights, through a variety of activity variables. The effect of time of day as an extrinsic factor, and sex, stage, mating status and nutritional status as physiological factors on the response of bed bugs to the volatiles was examined. Bed bugs of both sexes and all stages responded to the volatiles from bed bug-exposed papers, showing significant attraction and orientation towards the volatile source whether they were starved or engorged. Confirmation that the physiological factors examined do not affect the response of bed bugs to the volatiles from bed bug-exposed papers provides evidence that these bed bug-derived volatiles contain aggregation cues, as semiochemicals that promote aggregation should by definition be detected by both sexes and all life stages. A device baited with such semiochemicals could play a major role in limiting the impact of the current bed bug resurgence by enabling timely detection of infestations, along with quantitative evaluation of control and effective surveillance of the geographical distribution of the pest species.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
el-Mofty, M.M.; Sakr, S.A.; Younis, M.W.
Bed bugs, Cimex lectularius, irradiated with gamma rays were allowed to suck blood from shaved areas of the skin of rabbits, Oryctolagus cuniculus, 2 times/week for 5 months and then once weekly for another 5 months. This significantly induced the formation of skin papillomas and sweat gland hyperplasia in five out of nine experimental animals. It is speculated that the saliva of the irradiated bugs was activated by gamma rays and was responsible for the induction of skin papillomas. Because bed bugs play a significant role in the transmission of virus, it is also speculated that there is a virusmore » in the saliva of bugs; this virus may be activated by gamma radiation and causes the development of papillomas in the skin.« less
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The Let's Beat the Bug! Campaign--A Statewide Active Public Education Against Bed Bugs in Minnesota.
Shindelar, Amelia K
2017-03-01
Bed bugs continue to affect society and place a burden on public health systems. Experiences of the Let’s Beat the Bug! campaign are presented to help information networks prepare personnel to effectively address questions about this pest. Following recommendations from the Minnesota state bed bug working group, an information line was established and the Web site (www.bedbugs.umn.edu) was revised. Data from both services were analyzed by geographic region and type of information requested. InformationLine primarily assisted people who had issues dealing with failed treatments and landlord reluctance to take effective measures against this pest. Web site visits indicated a preference for learning do-it-yourself control methods. There were commonalities in the information sought from both services. People were often looking for reassurance, in addition to information about basic prevention and control of bed bugs. We present here priority topics that public health personnel should be prepared to answer if they receive inquiries about bed bugs.
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Encounters with fierce dogs and itchy bedbugs: why my first field work failed
2014-01-01
This essay, which is the fifth in the series “Recollections, Reflections, and Revelations: Personal Experiences in Ethnobiology”, is a personal reminiscence by the researcher on his first field experience in Turkey in the late 1970s, which was a failure from an ethnobiological point of view but a success for a social scientist pursuing Turkic studies. The author later returned to ethnobiology during subsequent fieldwork on the Faroes. PMID:24885471
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Bed Bugs: The Australian Response
Doggett, Stephen L.; Orton, Christopher J.; Lilly, David G.; Russell, Richard C.
2011-01-01
Australia has experienced a sudden and unexpected resurgence in bed bug infestations from both Cimex lectularius L. and Cimex hemipterus F. A survey in 2006 revealed that infestations had increased across the nation by an average of 4,500% since the start of the decade. In response, a multi-disciplinary approach to combat the rise of this public health pest was implemented and involved the coordinated efforts of several organizations. The key components of the strategy included the introduction of a pest management standard ‘A Code of Practice for the Control of Bed Bug Infestations in Australia’ that defines and promotes ‘best practice’ in bed bug eradication, the development of a policy and procedural guide for accommodation providers, education of stakeholders in best management practices, and research. These strategies continue to evolve with developments that lead to improvements in ‘best practice’ while bed bugs remain problematic in Australia. PMID:26467616
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2013-03-22
insects, such as mosquitoes and sand flies. Currently, in the Afghanistan area of operations (AO), there is an intermediate to high risk for vector...Agency (EPA) to kill flies, mosquitoes , gnats, bedbugs, and other arthropod pests. Available in two sizes, the strips are hung in an enclosed room with...toluamide (DEET) to repel biting insects, further assists in protecting exposed personnel. Buildings and areas are also protected from insects by
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Effects of starvation and molting on the metabolic rate of the bed bug (Cimex lectularius L.).
DeVries, Zachary C; Kells, Stephen A; Appel, Arthur G
2015-01-01
The bed bug (Cimex lectularius L.) is a common hematophagous pest in the urban environment and is capable of surviving extended periods of starvation. However, the relationship between starvation and metabolism in bed bugs is not well understood. To better understand this relationship, we measured the metabolism of all life stages for >900 h after feeding (starvation) using closed-system respirometry. Measurements were made around molting for the immature life stages, which occurs only after a blood meal. In addition, both mated and unmated adults were measured. Starvation and molting had significant effects on the metabolism of the bed bug. Mass-specific metabolic rate (V(O2); mL g(-1) h(-1)) declined in a curvilinear fashion with the period of starvation for adults and with the postmolting period for immature bed bugs (used to standardize all immature life stages). A standard curve was developed to depict the generalized pattern of metabolic decline observed in all life stages that molted. Individual metabolic comparisons among life stages that molted revealed some differences in metabolic rate between unmated males and females. In addition, the mass scaling coefficient was found to decline with starvation time (postmolting time) for all life stages that molted. In most life stages, the ratio of V(CO2) to V(O2) (respiratory exchange ratio) declined over time, indicating a change in metabolic substrate with starvation. Finally, daily percent loss in body mass declined in a pattern similar to that of V(O2). The observed patterns in metabolic decline are evaluated in relation to the life history of bed bugs. In addition, the evolutionary development of these patterns is discussed. The metabolic pattern after feeding was also found to share several similarities with that of other ectothermic species.
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Wang, Desen; Wang, Changlu; Singh, Narinderpal; Cooper, Richard; Zha, Chen; Eiden, Amanda L
2016-04-28
We investigated male mate choice and mating competency in the common bed bug, Cimex lectularius L., using video tracking for 10 min per experiment. In the male mate choice experiment, when a male was placed with two females of different mating status, males preferred to initiate copulation with the virgin female more quickly than with the mated female, and the mean total copulation duration with virgin females (38.0 ± 3.0 s) was significantly longer than with mated females (14.6 ± 3.0 s). When a male was placed with two females of different age, males initiated copulation more quickly with the old virgin female (29-34 d adult emergence) than with the young virgin one (<7 d adult emergence), and the mean total copulation duration with old virgin females (38.4 ± 4.0 s) was significantly longer than with young virgin females (24.0 ± 3.0 s). In the male mating competency experiment where a female was placed with two males of different mating status or age, the virgin males were more eager to mate than the mated males, and the old virgin males (29-34 d adult emergence) were more eager than the young virgin males (<7 d adult emergence), with eagerness measured by the percentage of first mate selected (first copulation occurred) and the total copulation duration by each group of males. Male mating competency is related to postmating duration (PMD); males mated 1 d earlier were significantly less likely to mate than virgin males. However, males mated 7 d earlier showed no significant difference in mating competency compared to virgin males. In conclusion, mate choice in C. lectularius is associated with both male and female mating status, age, and PMD. © The Authors 2016. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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Raab, Ronald W.; Moore, Julia E.; Vargo, Edward L.; Rose, Lucy; Raab, Julie; Culbreth, Madeline; Burzumato, Gracie; Koyee, Aurvan; McCarthy, Brittany; Raffaele, Jennifer; Schal, Coby; Vaidyanathan, Rajeev
2016-01-01
Infestations of the common bed bug (Cimex lectularius L.) have increased substantially in the United States in the past 10–15 years. The housing authority in Harrisonburg, Virginia, conducts heat-treatments after bed bugs are detected in a lower-income housing complex, by treating each infested unit at 60°C for 4–6 hours. However, a high frequency of recurrent infestations called into question the efficacy of this strategy. Genetic analysis using Bayesian clustering of polymorphic microsatellite loci from 123 bed bugs collected from 23 units from May 2012 to April 2013 in one building indicated that (a) 16/21 (73%) infestations were genetically similar, suggesting ineffective heat-treatments or reintroductions from within the building or from a common external source, followed by local spread of existing populations; and (b) up to 5 of the infestations represented new genotypes, indicating that 5 new populations were introduced into this building in one year, assuming they were not missed in earlier screens. There was little to no gene flow among the 8 genetic clusters identified in the building. Bed bugs in the U.S. often possess one or both point mutations in the voltage-gated sodium channel, termed knockdown resistance (kdr), from valine to leucine (V419L) and leucine to isoleucine (L925I) that confer target-site resistance against pyrethroid insecticides. We found that 48/121 (40%) bed bugs were homozygous for both kdr mutations (L419/I925), and a further 59% possessed at least one of the kdr mutations. We conclude that ineffective heat treatments, new introductions, reintroductions and local spread, and an exceptionally high frequency of pyrethroid resistance are responsible for chronic infestations in lower-income housing. Because heat treatments fail to protect from reintroductions, and pesticide use has not decreased the frequency of infestations, preventing new introductions and early detection are the most effective strategies to avoid bed bug infestations in multistory apartment buildings. PMID:26901153
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Laboratory rearing of bed bugs
USDA-ARS?s Scientific Manuscript database
The resurgence of bed bugs Cimex lectularius L. in the United States and worldwide has resulted in an increase in research by university, government, and industry scientists directed at the biology and control of this blood-sucking pest. A need has subsequently arisen for producing sufficient biolog...
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Cuticular hydrocarbons from the bed bug Cimex lectularius L.
USDA-ARS?s Scientific Manuscript database
Pentane extracts of male and female bed bugs were analyzed by gas chromatography and mass spectrometry in an effort to identify cuticular hydrocarbons. Seventeen hydrocarbons accounting for nearly 99% of the compounds eluting in the cuticular hydrocarbon region were identified. The sample contained ...
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Essential oils as fumigants for bed bugs (Hemiptera: Cimicidae)
USDA-ARS?s Scientific Manuscript database
In Petri dish assays, fumigation of a pyrethroid-susceptible strain of bed bugs Cimex lectularius L. (Hemiptera: Cimicidae) with various essential oils resulted in mortality that approached or equaled 100%, after 5 days. However, when bed bugs were exposed to the same essential oils in sealed, comme...
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USDA-ARS?s Scientific Manuscript database
Bed bugs Cimex lectularius were treated with conidia of the entomopathogenic fungus Metarhizium anisopliae by topical, spray, and contact exposure. One week post-exposure, inconsistent mortalities were observed, averaging 30% across all treatment groups and replicates. Microscopic examination of top...
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75 FR 858 - Propoxur; Receipt of Application for Emergency Exemption; Solicitation of Public Comment
Federal Register 2010, 2011, 2012, 2013, 2014
2010-01-06
..., and commercial industrial buildings to control bed bugs (Cimex lectularius). The applicant proposes a..., modes of transportation, and commercial industrial buildings to control bed bugs. Information in... existing labeled insecticides, in part due to pyrethroid resistance in the bed bug population. Bed bugs are...
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Unique features of a global human ectoparasite identified through sequencing of the bed bug genome
USDA-ARS?s Scientific Manuscript database
The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the last two decades. This global resurgence is likely linked to increased international travel and commerce and widespread insecticide resistance. Analyses of the C. le...
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USDA-ARS?s Scientific Manuscript database
A large variety of releaser pheromones are used by insects to attract or disperse conspecifics, while group cohesion is often influenced by primer pheromones that induce behavioral or physiological changes. Differentiating the roles of such pheromones in insect taxa displaying intermediate levels of...
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Bendjeddou, Mohammed Lamine; Loumassine, Hibat Allah; Scheffler, Ingo; Bouslama, Zihad; Amr, Zuhair
2017-06-01
Twenty two species of ectoparasites (Family Nycteribiidae: Nycteribia (Listropoda) schmidlii schmidlii, Nycteribia (Nycteribia) latreillii, Nycteribia (Nycteribia) pedicularia, Penicillidia (Penicillidia) dufourii, and Phthiridium biarticulatum; Family Streblidae: Brachytarsina (Brachytarsina) flavipennis and Raymondia huberi; Order Siphonaptera: Rhinolophopsylla unipectinata arabs, Nycteridopsylla longiceps, Araeopsylla gestroi, Ischnopsyllus intermedius, and Ischnopsyllus octactenus; Order Heteroptera: Cimex pipistrelli, Cimex lectularius, and Cacodmus vicinus; Class Arachnida: Order Mesostigmata: Spinturnix myoti and Eyndhovenia euryalis; Order Ixodida: Family Argasidae: Argas transgariepinus and Argas vespertilionis; Family Ixodidae: Hyalomma dromedarii, Ixodes ricinus, and Ixodes vespertilionis) were recovered from 19 bat species in Algeria. New host records for bats are recorded for the first time: N. schmidlii from Rh. clivosus and R. cystops; N. latreillii from Rh. blasii and P. gaisleri; R. huberi from Rh. clivosus; C. pipistrelli from E. isabellinus and H. savii; C. vicinus from E. isabellinus; S. myoti from P. gaisleri; E. euryalis from P. gaisleri and Rh. blasii; A. vespertilionis from P. gaisleri; I. ricinus from T. teniotis and Rh. hipposideros and H. dromedarii from P. kuhlii. Raymondia huberi is recorded for the first time from Algeria. © 2017 The Society for Vector Ecology.
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Drinking a hot blood meal elicits a protective heat shock response in mosquitoes.
Benoit, Joshua B; Lopez-Martinez, Giancarlo; Patrick, Kevin R; Phillips, Zachary P; Krause, Tyler B; Denlinger, David L
2011-05-10
The mosquito's body temperature increases dramatically when it takes a blood meal from a warm-blooded, vertebrate host. By using the yellow fever mosquito, Aedes aegypti, we demonstrate that this boost in temperature following a blood meal prompts the synthesis of heat shock protein 70 (Hsp70). This response, elicited by the temperature of the blood meal, is most robust in the mosquito's midgut. When RNA interference is used to suppress expression of hsp70, protein digestion of the blood meal is impaired, leading to production of fewer eggs. We propose that Hsp70 protects the mosquito midgut from the temperature stress incurred by drinking a hot blood meal. Similar increases in hsp70 were documented immediately after blood feeding in two other mosquitoes (Culex pipiens and Anopheles gambiae) and the bed bug, Cimex lectularius, suggesting that this is a common protective response in blood-feeding arthropods.
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Cooper, Richard; Wang, Changlu; Singh, Narinderpal
2015-01-01
Understanding movement and dispersal of the common bed bug (Cimex lectularius L.) under field conditions is important in the control of infestations and for managing the spread of bed bugs to new locations. We investigated bed bug movement within and between apartments using mark-release-recapture (m-r-r) technique combined with apartment-wide monitoring using pitfall-style interceptors. Bed bugs were collected, marked, and released in six apartments. The distribution of marked and unmarked bed bugs in these apartments and their 24 neighboring units were monitored over 32 days. Extensive movement of marked bed bugs within and between apartments occurred regardless of the number of bed bugs released or presence/absence of a host. Comparison of marked and unmarked bed bug distributions confirms that the extensive bed bug activity observed was not an artifact of the m-r-r technique used. Marked bed bugs were recovered in apartments neighboring five of six m-r-r apartments. Their dispersal rates at 14 or 15 d were 0.0–5.0%. The estimated number of bed bugs per apartment in the six m-r-r apartments was 2,433–14,291 at 4–7 d after release. Longevity of bed bugs in the absence of a host was recorded in a vacant apartment. Marked large nymphs (3rd– 5th instar), adult females, and adult males continued to be recovered up to 57, 113, and 134 d after host absence, respectively. Among the naturally existing unmarked bed bugs, unfed small nymphs (1st– 2nd instar) were recovered up to 134 d; large nymphs and adults were still found at 155 d when the study ended. Our findings provide important insight into the behavioral ecology of bed bugs in infested apartments and have significant implications in regards to eradication programs and managing the spread of bed bugs within multi-occupancy dwellings. PMID:26352145
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Zhu, Fang; Sams, Sarah; Moural, Tim; Haynes, Kenneth F.; Potter, Michael F.; Palli, Subba R.
2012-01-01
Background NADPH-cytochrome P450 reductase (CPR) plays a central role in cytochrome P450 action. The genes coding for P450s are not yet fully identified in the bed bug, Cimex lectularius. Hence, we decided to clone cDNA and knockdown the expression of the gene coding for CPR which is suggested to be required for the function of all P450s to determine whether or not P450s are involved in resistance of bed bugs to insecticides. Methodology/Principal Findings The full length Cimex lectularius CPR (ClCPR) cDNA was isolated from a deltamethrin resistant bed bug population (CIN-1) using a combined PCR strategy. Bioinformatics and in silico modeling were employed to identify three conserved binding domains (FMN, FAD, NADP), a FAD binding motif, and the catalytic residues. The critical amino acids involved in FMN, FAD, NADP binding and their putative functions were also analyzed. No signal peptide but a membrane anchor domain with 21 amino acids which facilitates the localization of ClCPR on the endoplasmic reticulum was identified in ClCPR protein. Phylogenetic analysis showed that ClCPR is closer to the CPR from the body louse, Pediculus humanus corporis than to the CPRs from the other insect species studied. The ClCPR gene was ubiquitously expressed in all tissues tested but showed an increase in expression as immature stages develop into adults. We exploited the traumatic insemination mechanism of bed bugs to inject dsRNA and successfully knockdown the expression of the gene coding for ClCPR. Suppression of the ClCPR expression increased susceptibility to deltamethrin in resistant populations but not in the susceptible population of bed bugs. Conclusions/Significance These data suggest that P450-mediated metabolic detoxification may serve as one of the resistance mechanisms in bed bugs. PMID:22347424
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Zhu, Fang; Sams, Sarah; Moural, Tim; Haynes, Kenneth F; Potter, Michael F; Palli, Subba R
2012-01-01
NADPH-cytochrome P450 reductase (CPR) plays a central role in cytochrome P450 action. The genes coding for P450s are not yet fully identified in the bed bug, Cimex lectularius. Hence, we decided to clone cDNA and knockdown the expression of the gene coding for CPR which is suggested to be required for the function of all P450s to determine whether or not P450s are involved in resistance of bed bugs to insecticides. The full length Cimex lectularius CPR (ClCPR) cDNA was isolated from a deltamethrin resistant bed bug population (CIN-1) using a combined PCR strategy. Bioinformatics and in silico modeling were employed to identify three conserved binding domains (FMN, FAD, NADP), a FAD binding motif, and the catalytic residues. The critical amino acids involved in FMN, FAD, NADP binding and their putative functions were also analyzed. No signal peptide but a membrane anchor domain with 21 amino acids which facilitates the localization of ClCPR on the endoplasmic reticulum was identified in ClCPR protein. Phylogenetic analysis showed that ClCPR is closer to the CPR from the body louse, Pediculus humanus corporis than to the CPRs from the other insect species studied. The ClCPR gene was ubiquitously expressed in all tissues tested but showed an increase in expression as immature stages develop into adults. We exploited the traumatic insemination mechanism of bed bugs to inject dsRNA and successfully knockdown the expression of the gene coding for ClCPR. Suppression of the ClCPR expression increased susceptibility to deltamethrin in resistant populations but not in the susceptible population of bed bugs. These data suggest that P450-mediated metabolic detoxification may serve as one of the resistance mechanisms in bed bugs.
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USDA-ARS?s Scientific Manuscript database
Exposure of a pyrethroid-susceptible strain of bed bugs, Cimex lectularius L. (Hemiptera: Cimicidae) to varying concentrations of deltamethrin for 24h indicated there was no significant difference in mortality between males, females, and nymphs at 24h or 168h post-exposure. Most bed bugs classified ...
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Bed bugs can cause severe anaemia in adults.
Paulke-Korinek, Maria; Széll, Marton; Laferl, Hermann; Auer, Herbert; Wenisch, Christoph
2012-06-01
A 60-year-old woman and her 67-year-old male partner, admitted for pneumonia and non-ST elevation myocardial infarction, respectively, had severe anaemia (Hb 5.3 and 5.2 g/dL, respectively), as a result from massive infestation with Cimex lectularius. After two erythrocyte transfusions and thorough decontamination, their clinical course was unremarkable.
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4-Oxo-Aldehydes from the dorsal abdominal glands of the bed bug (hemiptera: cimicidae)
USDA-ARS?s Scientific Manuscript database
Analyses of the dorsal abdominal glands of fourth- and fifth-instar nymphs of the bed bud Cimex lectularius L. indicated the predominant constituents were (E)-2-hexenal and (E)-2-octenal with lesser amounts of 4-oxo-(E)-2-hexenal and 4-oxo-(E)-2-octenal. The latter two compounds have not previously...
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USDA-ARS?s Scientific Manuscript database
The two major aldehydes (E)-2-hexenal and (E)-2-octenal emitted as defensive secretions by bed bugs Cimex lectularius L. (Hemiptera: Cimicidae), inhibit the in vitro growth of Metarhizium anisopliae (Metsch.) Sokorin (Hypocreales: Clavicipitaceae). These chemicals inhibit fungal growth by direct con...
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Akhoundi, Mohammad; Cannet, Arnaud; Loubatier, Céline; Berenger, Jean-Michel; Izri, Arezki; Marty, Pierre; Delaunay, Pascal
2016-01-01
Wolbachia symbionts are maternally inherited intracellular bacteria that have been detected in numerous insects including bed bugs. The objective of this study, the first epidemiological study in Europe, was to screen Wolbachia infection among Cimex lectularius collected in the field, using PCR targeting the surface protein gene (wsp), and to compare obtained Wolbachia strains with those reported from laboratory colonies of C. lectularius as well as other Wolbachia groups. For this purpose, 284 bed bug specimens were caught and studied from eight different regions of France including the suburbs of Paris, Bouches-du-Rhône, Lot-et-Garonne, and five localities in Alpes-Maritimes. Among the samples, 166 were adults and the remaining 118 were considered nymphs. In all, 47 out of 118 nymphs (40%) and 61 out of 166 adults (37%) were found positive on wsp screening. Among the positive cases, 10 samples were selected randomly for sequencing. The sequences had 100% homology with wsp sequences belonging to the F-supergroup strains of Wolbachia. Therefore, we confirm the similarity of Wolbachia strains detected in this epidemiological study to Wolbachia spp. reported from laboratory colonies of C. lectularius. PMID:27492563
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Neuropeptidomics of the Bed Bug Cimex lectularius.
Predel, Reinhard; Neupert, Susanne; Derst, Christian; Reinhardt, Klaus; Wegener, Christian
2018-01-05
The bed bug Cimex lectularius is a globally distributed human ectoparasite with fascinating biology. It has recently acquired resistance against a broad range of insecticides, causing a worldwide increase in bed bug infestations. The recent annotation of the bed bug genome revealed a full complement of neuropeptide and neuropeptide receptor genes in this species. With regard to the biology of C. lectularius, neuropeptide signaling is especially interesting because it regulates feeding, diuresis, digestion, as well as reproduction and also provides potential new targets for chemical control. To identify which neuropeptides are translated from the genome-predicted genes, we performed a comprehensive peptidomic analysis of the central nervous system of the bed bug. We identified in total 144 different peptides from 29 precursors, of which at least 67 likely present bioactive mature neuropeptides. C. lectularius corazonin and myosuppressin are unique and deviate considerably from the canonical insect consensus sequences. Several identified neuropeptides likely act as hormones, as evidenced by the occurrence of respective mass signals and immunoreactivity in neurohemal structures. Our data provide the most comprehensive peptidome of a Heteropteran species so far and in comparison suggest that a hematophageous life style does not require qualitative adaptations of the insect peptidome.
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Functional characterization of Aquaporin-like genes in the human bed bug Cimex lectularius.
Tsujimoto, Hitoshi; Sakamoto, Joyce M; Rasgon, Jason L
2017-06-12
The bed bug Cimex lectularius is a blood-feeding re-emerging annoyance pest insect that has the ability to transmit Trypanosoma cruzi under experimental laboratory conditions. Aquaporins (AQPs) are water channel proteins that are essential in biological organisms. C. lectularius are constantly exposed to water-related stress, suggesting that AQPs may offer novel control avenues. We identified and cloned four AQPs from C. lectularius, assessed tissue and lifestage-specific expression, and characterized biochemical functions in vitro and in vivo. We identified an efficient water-specific AQP (ClAQP1), two aquaglyceroporins (ClGlp1 and ClGlp2) and a homolog of Drosophila melanogaster big brain (ClBib). ClGlp1 was only functional when co-expressed with the water-specific AQP. Simultaneous RNAi gene silencing of ClAQP1 and ClGlp1 significantly reduced water and urea excretion post blood feeding. The Bib homologue was enriched in embryos, exclusively expressed in ovaries, and when silenced, dramatically increased bug fecundity. Our data demonstrate that AQPs have critical roles in excretion, water homeostasis and reproduction in C. lectularius, and could be potential targets for control in this notorious pest.
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Choe, Dong-Hwan; Park, Hoeun; Vo, Claudia; Knyshov, Alexander
2016-01-01
Extracts of the exuviae (cast skins) of nymphal bed bugs (Cimex lectularius) were analyzed for volatile compounds that might contribute to arrestment of adult bed bugs. Four volatile aldehydes, (E)-2-hexenal, 4-oxo-(E)-2-hexenal, (E)-2-octenal, and 4-oxo-(E)-2-octenal were consistently detected in the headspace of freshly shed exuviae regardless of the developmental stages from which the exuviae were obtained. Quantification of the aldehydes in the solvent extracts of homogenized fresh, 45- or 99-d aged 5th instar exuviae indicated that the aldehydes are present in the exuviae and dissipate over time, through evaporation or degradation. Microscopic observation of the fifth instar exuviae indicated that the dorsal abdominal glands on the exuviae maintained their pocket-like structures with gland reservoirs, within which the aldehydes might be retained. Two-choice olfactometer studies with the volatiles from exuviae or a synthetic blend mimicking the volatiles indicated that adult bed bugs tend to settle close to sources of the aldehydes. Our results imply that the presence and accumulation of bed bug exuviae and the aldehydes volatilizing from the exuviae might mediate bed bugs' interaction with their microhabitats.
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Choe, Dong-Hwan; Park, Hoeun; Vo, Claudia; Knyshov, Alexander
2016-01-01
Extracts of the exuviae (cast skins) of nymphal bed bugs (Cimex lectularius) were analyzed for volatile compounds that might contribute to arrestment of adult bed bugs. Four volatile aldehydes, (E)-2-hexenal, 4-oxo-(E)-2-hexenal, (E)-2-octenal, and 4-oxo-(E)-2-octenal were consistently detected in the headspace of freshly shed exuviae regardless of the developmental stages from which the exuviae were obtained. Quantification of the aldehydes in the solvent extracts of homogenized fresh, 45- or 99-d aged 5th instar exuviae indicated that the aldehydes are present in the exuviae and dissipate over time, through evaporation or degradation. Microscopic observation of the fifth instar exuviae indicated that the dorsal abdominal glands on the exuviae maintained their pocket-like structures with gland reservoirs, within which the aldehydes might be retained. Two-choice olfactometer studies with the volatiles from exuviae or a synthetic blend mimicking the volatiles indicated that adult bed bugs tend to settle close to sources of the aldehydes. Our results imply that the presence and accumulation of bed bug exuviae and the aldehydes volatilizing from the exuviae might mediate bed bugs’ interaction with their microhabitats. PMID:27434044
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Bed Bugs: Clinical Relevance and Control Options
Dwyer, Dominic E.; Peñas, Pablo F.; Russell, Richard C.
2012-01-01
Summary: Since the late 1990s, bed bugs of the species Cimex lectularius and Cimex hemipterus have undergone a worldwide resurgence. These bed bugs are blood-sucking insects that readily bite humans. Cutaneous reactions may occur and can start out as small macular lesions that can develop into distinctive wheals of around 5 cm in diameter, which are accompanied by intense itching. Occasionally, bullous eruptions may result. If bed bugs are numerous, the patient can present with widespread urticaria or eythematous rashes. Often, bites occur in lines along the limbs. Over 40 pathogens have been detected in bed bugs, but there is no definitive evidence that they transmit any disease-causing organisms to humans. Anemia may result when bed bugs are numerous, and their allergens can trigger asthmatic reactions. The misuse of chemicals and other technologies for controlling bed bugs has the potential to have a deleterious impact on human health, while the insect itself can be the cause of significant psychological trauma. The control of bed bugs is challenging and should encompass a multidisciplinary approach utilizing nonchemical means of control and the judicious use of insecticides. For accommodation providers, risk management procedures should be implemented to reduce the potential of bed bug infestations. PMID:22232375
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Basnet, Sanjay; Kamble, Shripat T
2018-05-04
The common bed bug, Cimex lectularius L. (Hemiptera: Cimicidae) is a nuisance household pest causing significant medical and economic impacts. RNA interference (RNAi) of genes that are involved in vital physiological processes can serve as potential RNAi targets for insect control. Brahma is an ATPase subunit of a chromatin-remodeling complex involved in transcription of several genes for cellular processes, most importantly the homeotic genes. In this study, we used a microinjection technique to deliver double stranded RNA into female bed bugs. Delivery of 0.05 and 0.5 µg/insect of brahma dsRNA directly into hemocele resulted substantial reduction in oviposition. Eggs laid by bed bugs receiving both doses of brahma dsRNA exhibited significantly lower hatching percentage as compared to controls. In addition, brahma RNAi in female bed bugs caused significant mortality. Our results disclosed the potential of brahma RNAi to suppress bed bug population through injection of specific dsRNA, suggesting a critical function of this gene in bed bugs' reproduction and survival. Based on our data, brahma can be a promising RNAi target for suppression of bed bug population.
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Sadílek, David; Šťáhlavský, František; Vilímová, Jitka; Zima, Jan
2013-01-01
Abstract Variation in the number of chromosomes was revealed in 61 samples of Cimex lectularius Linnaeus, 1758 from the Czech Republic and other European countries, hosted on Myotis Kaup, 1829 (4) and Homo sapiens Linnaeus, 1758 (57). The karyotype of all the specimens of Cimex lectularius analysed contained 26 autosomes and a varying number of the sex chromosomes. The number of sex chromosomes showed extensive variation, and up to 20 fragments were recorded. Altogether, 12 distinct karyotypes were distinguished. The male karyotypes consisted of 29, 30, 31, 32, 33, 34, 35, 36, 37, 40, 42 and 47 chromosomes. The females usually exhibited the number of chromosomes which was complementary to the number established in the males from the same sample. However, 11 polymorphic samples were revealed in which the karyotypes of females and males were not complementary each other. The complement with 2n = 26+X1X2Y was found in 44% of the specimens and 57,4% samples of bed bugs studied. The karyotypes with higher chromosome numbers as well as individuals with chromosomal mosaics were usually found within the samples exhibiting particularly extensive variation between individuals, and such complements were not found within samples contaning a few or single specimen. The occurrence of chromosomal mosaics with the karyotype constitution varying between cells of single individual was observed in five specimens (4.3%) from five samples. We assume that polymorphism caused by fragmentation of the X chromosome may result in meiotic problems and non-disjunction can produce unbalanced gametes and result in lowered fitness of individuals carrying higher numbers of the X chromosome fragments. This effect should be apparently enhanced with the increasing number of the fragments and this may be the reason for the observed distribution pattern of individual karyotypes in the studied samples and the rarity of individuals with extremely high chromosome numbers. The assumed lowering of the fitness of individuals carrying higher numbers of the X chromosome fragments could affect population dynamics of variable populations. PMID:24455100
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Hottel, Benjamin A; Pereira, Roberto M; Koehler, Philip G
2015-05-12
Two-choice tests were conducted to examine the effect of surface roughness on the resting preference of bed bugs, Cimex lectularius L., on copper, basswood, and acrylic materials. The influence of pyrethroid formulation applications on resting preferences was also evaluated. Bed bugs were given the choice of resting between two sanded halves of each material tested. One half was sanded with a P60 grit sandpaper and the other with a less rough P600 grit sandpaper. A significantly higher proportion of bed bugs chose to rest on the rougher P60 grit sanded half of all materials tested. Pyrethroid applications were made to either the P60 grit half or both halves of acrylic arenas and resting preferences were again assessed. Behavioral responses of bed bugs to pyrethroid formulation applications varied depending on the bed bug strain used and the formulation applied. Bed bugs would still rest on the P60 grit half when Suspend SC formulation (0.06% deltamethrin) was applied; however, an avoidance response was observed from a bed bug strain susceptible to D-Force aerosol formulations (0.06% deltamethrin). The avoidance behavior is likely attributed to one, more than one, or even an interaction of multiple spray constituents and not the active ingredient.
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Crawley, Sydney E; Kowles, Katelyn A; Gordon, Jennifer R; Potter, Michael F; Haynes, Kenneth F
2017-03-01
Bed bugs (Cimex lectularius) are blood-feeding insect pests with public health relevance. Their rapid evolution of resistance to pyrethroids has prompted a shift to combination products that include both a pyrethroid and neonicotinoid insecticide. Insecticides have both a direct impact on mortality and an indirect effect on behavior. Thus, we assessed the sublethal effects of a widely used combination product containing β-cyfluthrin (a pyrethroid) and imidacloprid (a neonicotinoid), as unexpected behavioral changes after exposure have been known to affect efficacy of insecticides. We found that bed bugs exposed to sublethal doses of a combination product containing β-cyfluthrin and imidacloprid did not feed as effectively as untreated bugs. Their locomotion behavior was also reduced. However, aggregation in response to the presence of conspecific harborages was not affected by sublethal exposure. Bed bugs exhibit behavioral changes after sublethal exposure to a combination product that could affect pest management choices and outcomes. A reduction in host-finding efficiency and feeding could complement the lethal effects of the insecticide. Alternatively, reduced locomotion following exposure could limit ongoing contact with insecticide deposits. However, an overall reduction in movement indicates that treatments are unlikely to cause dispersal of bugs to adjacent dwellings. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.
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Wang, Changlu; Eiden, Amanda; Singh, Narinderpal; Zha, Chen; Wang, Desen; Cooper, Richard
2018-06-01
Infestations of the common bed bug, Cimex lectularius L., have become common in low-income communities in the USA over the last 15 years. We evaluated community-based integrated pest management (IPM) programs for reducing bed bug infestations. Two housing authorities (Bayonne and Hackensack) implemented bed bug IPM programs. A third housing authority (Paterson) was used as the control site. Building-wide surveys were conducted in all communities, three times, to evaluate the effectiveness of the IPM programs. From 0 to 24 months, the infestation rate at Bayonne, Hackensack, and Paterson decreased by 49, 64, and 26%, respectively. The two sites that adopted IPM achieved faster bed bug elimination than the control site. The bed bug introduction rate over a 24-month period at Bayonne, Hackensack, and Paterson was 7, 3, and 11%, respectively. The introduction rate was positively associated with the initial infestation rate. Residents from buildings enrolled in IPM programs were more satisfied with the bed bug control services than residents from the control site. IPM programs were more effective in reducing bed bug infestations than traditional pest control services, but many factors contributed to the lower than desired level of reduction in infestation rate. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.
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McNeill, C A; Allan, S A; Koehler, P G; Pereira, R M; Weeks, E N I
2016-12-01
Bed bugs as pests of public health importance recently experienced a resurgence in populations throughout the U.S. and other countries. Consequently, recent research efforts have focused on improving understanding of bed bug physiology and behaviour to improve management. While few studies have investigated the visual capabilities of bed bugs, the present study focused specifically on eye morphology and spectral sensitivity. A 3-D imaging technique was used to document bed bug eye morphology from the first instar through adult and revealed morphological characteristics that differentiate the common bed bug from the tropical bed bug as well as sex-specific differences. Electrophysiological measurements were used to evaluate the spectral sensitivity of adult bed bugs. Male bed bugs were more responsive than females at some wavelengths. Electrophysiological studies provided evidence for at least one photoreceptor with a spectral sensitivity curve peak in the green (λ max 520 nm) region of the spectrum. The broadened long wavelength portion of the spectral sensitivity curve may potentially indicate another photoreceptor in the yellow-green (λ max 550 nm) portion of the spectrum or screening pigments. Understanding more about bed bug visual biology is vital for designing traps, which are an important component of integrated bed bug management. © 2016 The Royal Entomological Society.
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Role of Vision and Mechanoreception in Bed Bug, Cimex lectularius L. Behavior
Singh, Narinderpal; Wang, Changlu; Cooper, Richard
2015-01-01
The role of olfactory cues such as carbon dioxide, pheromones, and kairomones in bed bug, Cimex lectularius L. behavior has been demonstrated. However, the role of vision and mechanoreception in bed bug behavior is poorly understood. We investigated bed bug vision by determining their responses to different colors, vertical objects, and their ability to detect colors and vertical objects under low and complete dark conditions. Results show black and red paper harborages are preferred compared to yellow, green, blue, and white harborages. A bed bug trapping device with a black or red exterior surface was significantly more attractive to bed bugs than that with a white exterior surface. Bed bugs exhibited strong orientation behavior toward vertical objects. The height (15 vs. 30 cm tall) and color (brown vs. black) of the vertical object had no significant effect on orientation behavior of bed bugs. Bed bugs could differentiate color and detect vertical objects at very low background light conditions, but not in complete darkness. Bed bug preference to different substrate textures (mechanoreception) was also explored. Bed bugs preferred dyed tape compared to painted tape, textured painted plastic, and felt. These results revealed that substrate color, presence of vertical objects, and substrate texture affect host-seeking and harborage-searching behavior of bed bugs. Bed bugs may use a combination of vision, mechanoreception, and chemoreception to locate hosts and seek harborages. PMID:25748041
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Devries, Zachary C; Kells, Stephen A; Appel, Arthur G
2013-11-01
Metabolic rates provide important information about the biology of organisms. For ectothermic species such as insects, factors such as temperature and mass heavily influence metabolism, but these effects differ considerably between species. In this study we examined the standard metabolic rate of the bed bug, Cimex lectularius L. We used closed system respirometry and measured both O2 consumption and CO2 production across a range of temperatures (10, 20, 25, 30, 35°C) and life stages, while also accounting for activity. Temperature had a stronger effect on the mass specific .VO2 (mlg(-1)h(-1)) of mated males (Q10=3.29), mated females (Q10=3.19), unmated males (Q10=3.09), and nymphs that hatched (first instars, Q10=3.05) than on unmated females (Q10=2.77) and nymphs that molted (second through fifth instars, Q10=2.78). First instars had significantly lower respiratory quotients (RQ) than all other life stages. RQ of all stages was not affected by temperature. .VO2 (mlh(-1)) scaled more with mass than values previously reported for other arthropods or that would be predicted by the 3/4-power law. The results are used to understand the biology and ecology of the bed bug. Copyright © 2013 Elsevier Ltd. All rights reserved.
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Role of vision and mechanoreception in bed bug, Cimex lectularius L. behavior.
Singh, Narinderpal; Wang, Changlu; Cooper, Richard
2015-01-01
The role of olfactory cues such as carbon dioxide, pheromones, and kairomones in bed bug, Cimex lectularius L. behavior has been demonstrated. However, the role of vision and mechanoreception in bed bug behavior is poorly understood. We investigated bed bug vision by determining their responses to different colors, vertical objects, and their ability to detect colors and vertical objects under low and complete dark conditions. Results show black and red paper harborages are preferred compared to yellow, green, blue, and white harborages. A bed bug trapping device with a black or red exterior surface was significantly more attractive to bed bugs than that with a white exterior surface. Bed bugs exhibited strong orientation behavior toward vertical objects. The height (15 vs. 30 cm tall) and color (brown vs. black) of the vertical object had no significant effect on orientation behavior of bed bugs. Bed bugs could differentiate color and detect vertical objects at very low background light conditions, but not in complete darkness. Bed bug preference to different substrate textures (mechanoreception) was also explored. Bed bugs preferred dyed tape compared to painted tape, textured painted plastic, and felt. These results revealed that substrate color, presence of vertical objects, and substrate texture affect host-seeking and harborage-searching behavior of bed bugs. Bed bugs may use a combination of vision, mechanoreception, and chemoreception to locate hosts and seek harborages.
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Sentana-Lledo, Daniel; Barbu, Corentin M; Ngo, Michelle N; Wu, Yage; Sethuraman, Karthik; Levy, Michael Z
2016-01-01
The common bed bug (Cimex lectularius L.) is once again prevalent in the United States. We investigated temporal patterns in Google search queries for bed bugs and co-occurring terms, and conducted in-person surveys to explore the intentions behind searches that included those terms. Searches for "bed bugs" rose steadily through 2011 and then plateaued, suggesting that the epidemic has reached an equilibrium in the United States. However, queries including terms that survey respondents associated strongly with having bed bugs (e.g., "exterminator," "remedies") continued to climb, while terms more closely associated with informational searches (e.g., "hotels," "about") fell. Respondents' rankings of terms and nonseasonal trends in Google search volume as assessed by a cosinor model were significantly correlated (Kendall's Tau-b P = 0.015). We find no evidence from Google Trends that the bed bug epidemic in the United States has reached equilibrium. © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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Wang, Changlu; Wen, Xiujun
2011-04-11
The bed bug resurgence in North America, Europe, and Australia has elicited interest in investigating the causes of the widespread and increasing infestations and in developing more effective control strategies. In order to extend global perspectives on bed bug management, we reviewed bed bug literature in China by searching five Chinese language electronic databases. We conducted telephone interviews of staff from 77 Health and Epidemic Prevention Stations in six Chinese cities in November 2010. We also conducted telephone interviews of 68 pest control firms in two cities during March 2011. Two species of bed bugs (Cimex lectularius L. and Cimex hemipterus (F.)) are known to occur in China. These were common urban pests before the early1980s. Nationwide "Four-Pest Elimination" campaigns (bed bugs being one of the targeted pests) were implemented in China from 1960 to the early 1980s. These campaigns succeeded in the elimination of bed bug infestations in most communities. Commonly used bed bug control methods included applications of hot water, sealing of bed bug harborages, physical removal, and applications of residual insecticides (mainly organophosphate sprays or dusts). Although international and domestic travel has increased rapidly in China over the past decade (2000-2010), there have only been sporadic new infestations reported in recent years. During 1999-2009, all documented bed bug infestations were found in group living facilities (military dormitories, worker dormitories, and prisons), hotels, or trains. One city (Shenzhen city near Hong Kong) experienced significantly higher number of bed bug infestations. This city is characterized by a high concentration of migratory factory workers. Current bed bug control practices include educating residents, washing, reducing clutter, putting items under the hot sun in summer, and applying insecticides (pyrethroids or organophosphates). There have not been any studies or reports on bed bug insecticide resistance. Difficulties of control were noted in our surveys of dormitories in which crowded living, seasonal worker migration, and financial constraints contributed to control failures. This study supports the following conclusions: (1) the bed bug infestation in China dramatically decreased following the campaigns from 1960 to the early 1980s; (2) In our survey of Health and Epidemics Prevention Stations, no bed bug cases were reported in Beijing and Shanghai for the past 12 months, but complaints were reported in Guangzhou, Lanzhou, Urumqi, and Shenzhen; (3) Current bed bug infestations primarily are reported in crowded living environments or transient environments such as worker dormitories and military dormitories. These findings suggest that community-wide bed bug monitoring and control campaigns are necessary for effective control of bed bug infestations as a societal response.
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Wang, Changlu; Wen, Xiujun
2011-01-01
The bed bug resurgence in North America, Europe, and Australia has elicited interest in investigating the causes of the widespread and increasing infestations and in developing more effective control strategies. In order to extend global perspectives on bed bug management, we reviewed bed bug literature in China by searching five Chinese language electronic databases. We conducted telephone interviews of staff from 77 Health and Epidemic Prevention Stations in six Chinese cities in November 2010. We also conducted telephone interviews of 68 pest control firms in two cities during March 2011. Two species of bed bugs (Cimex lectularius L. and Cimex hemipterus (F.)) are known to occur in China. These were common urban pests before the early1980s. Nationwide “Four-Pest Elimination” campaigns (bed bugs being one of the targeted pests) were implemented in China from 1960 to the early 1980s. These campaigns succeeded in the elimination of bed bug infestations in most communities. Commonly used bed bug control methods included applications of hot water, sealing of bed bug harborages, physical removal, and applications of residual insecticides (mainly organophosphate sprays or dusts). Although international and domestic travel has increased rapidly in China over the past decade (2000–2010), there have only been sporadic new infestations reported in recent years. During 1999–2009, all documented bed bug infestations were found in group living facilities (military dormitories, worker dormitories, and prisons), hotels, or trains. One city (Shenzhen city near Hong Kong) experienced significantly higher number of bed bug infestations. This city is characterized by a high concentration of migratory factory workers. Current bed bug control practices include educating residents, washing, reducing clutter, putting items under the hot sun in summer, and applying insecticides (pyrethroids or organophosphates). There have not been any studies or reports on bed bug insecticide resistance. Difficulties of control were noted in our surveys of dormitories in which crowded living, seasonal worker migration, and financial constraints contributed to control failures. This study supports the following conclusions: (1) the bed bug infestation in China dramatically decreased following the campaigns from 1960 to the early 1980s; (2) In our survey of Health and Epidemics Prevention Stations, no bed bug cases were reported in Beijing and Shanghai for the past 12 months, but complaints were reported in Guangzhou, Lanzhou, Urumqi, and Shenzhen; (3) Current bed bug infestations primarily are reported in crowded living environments or transient environments such as worker dormitories and military dormitories. These findings suggest that community-wide bed bug monitoring and control campaigns are necessary for effective control of bed bug infestations as a societal response. PMID:26467615
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Effect of Moxidectin on Bed Bug Feeding, Development, Fecundity, and Survivorship.
Zha, Chen; Wang, Changlu; Sheele, Johnathan Michael
2017-09-30
The common bed bug, Cimex lectularius L. (Hemiptera: Cimicidae), is a blood-feeding ectoparasite which experienced world-wide resurgence during recent decades. The control of bed bugs is often challenging, due to their cryptic nature and resistance to commonly used insecticides. In this study, we evaluated the effect of the antiparasitic drug moxidectin on bed bug survival, reproduction, and development. The LC 50 (lethal concentration to kill half the members of a tested population) of moxidectin against bed bug male adults, female adults, and large nymphs were 52.7 (95% CI (confidence interval): 39.5-70.8), 29.3 (95% CI: 20.7-40.5), and 29.1 ng/mL (95% CI: 23.3-35.3), respectively. Moxidectin (≥ 25 ng/mL) reduced egg laying of bed bug females, but showed no significant effect on egg hatching. One time feeding on rabbit blood containing 20 and 40 ng/mL moxidectin showed no negative effects in bed bug feeding and blood meal ingestion, but significantly reduced digestion rates and nymph molting rates. Although moxidectin at concentrations of 20 and 40 ng/mL only caused moderate mortality in bed bugs, it significantly interrupted digestion, development, and oviposition of survived bed bugs for at least one week after feeding. Moxidectin is a promising supplement of the existing bed bug control materials if its use on humans can be approved in the future.
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Crawley, Sydney E; Gordon, Jennifer R; Kowles, Katelyn A; Potter, Michael F; Haynes, Kenneth F
2017-01-01
Sublethal exposure to an insecticide may alter insect feeding, mating, oviposition, fecundity, development, and many other life history parameters. Such effects may have population-level consequences that are not apparent in traditional dose-mortality evaluations. Earlier, we found that a routinely used combination insecticide that includes a pyrethroid and a neonicotinoid (Temprid® SC) had deleterious effects on multiple bed bug (Cimex lectularius, L.) behaviors. Here, we demonstrate that sublethal exposure impacts physiology and reproduction as well. We report that sublethal exposure to Temprid SC has variable aberrant effects on bed bugs depending on the strain, including: a reduction in male mating success and delayed oviposition by females. However, after sublethal exposure, egg hatch rate consistently declined in every strain tested, anywhere from 34%-73%. Conversely, impact on fifth instar eclosion time was not significant. While the strains that we tested varied in their respective magnitude of sublethal effects, taken together, these effects could reduce bed bug population growth. These changes in bed bug behavior and fecundity could lead to improved efficacy of Temprid SC in the field, but recovery of impacted bugs must be considered in future studies. Sublethal effects should not be overlooked when evaluating insecticide efficacy, as it is likely that other products may also have indirect effects on population dynamics that could either aid or inhibit successful management of pest populations.
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Host-Seeking Behavior in the Bed Bug, Cimex lectularius.
Suchy, James T; Lewis, Vernard R
2011-03-07
The reemergence of the bed bug, Cimex lectularius Linnaeus, has recently spawned a frenzy of public, media, and academic attention. In response to the growing rate of infestation, considerable work has been focused on identifying the various host cues utilized by the bed bug in search of a meal. Most of these behavioral studies examine movement within a confined environment, such as a Petri dish. This has prevented a more complete understanding of the insect's host-seeking process. This work describes a novel method for studying host-seeking behavior, using various movement parameters, in a time-lapse photography system. With the use of human breath as an attractant, we qualitatively and quantitatively assessed how bed bugs navigate their environment between its harborage and the host. Levels of behavioral activity varied dramatically between bed bugs in the presence and absence of host odor. Bed bugs demonstrated not simply activation, but attraction to the chemical components of breath. Localized, stop-start host-seeking behavior or alternating periods of movement and pause were observed among bed bugs placed in the environment void of human breath, while those exposed to human breath demonstrated long range, stop-start host-seeking behavior. A more comprehensive understanding of bed bug host-seeking can lead to the development of traps and monitors that account for unique subtleties in their behavior. The time-lapse photography system uses a large, artificial environment and could also be employed to study other aspects of the insect's behavioral patterns.
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Seri Masran, Siti Nor Ain; Ab Majid, Abdul Hafiz
2018-05-04
Due to the growing public health and tourism awareness, Cimex hemipterus Fabricius (Hemiptera: Cimicidae) has gained a great interest in increasing reported infestation cases in tropical regions of the world, including Malaysia. Since the information on the molecular ecology and population biology of this species are tremendously lacking, the isolation and development of molecular markers can be used to determine its genetic structure. In this study, novel microsatellite primers isolated from enriched genomic libraries of C. hemipterus were developed using 454 Roche shotgun sequencing. Seven validated polymorphic microsatellite primers were consistently amplified and characterized from 70 tropical bed bugs collected from seven locations throughout Malaysia. The number of alleles per locus identified ranged from 6 to 14. Comparison of loci for overall and between population were done with mean observed and expected heterozygosity were determined at 0.320 and 0.814, 0.320 and 0.727, respectively. Polymorphic information criteria (PIC) valued the markers as highly informative as PIC >0.5. Overall population, they are possibly in Hardy-Weinberg equilibrium with loci Ch_09ttn, Ch_01dn, and Ch_13dn showing signs of a null allele. There were no scoring errors caused by stutter peaks, no large allele dropout was detected for all loci and showed no evidence of linkage disequilibrium. In conclusion, all seven molecular microsatellite markers identified can be beneficially used to gain more information on the population genetic structure and breeding patterns of C. hemipterus as well as the relationship of dispersal and infestation.
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Behavioral Responses of the Common Bed Bug, Cimex lectularius, to Insecticide Dusts.
Agnew, John L; Romero, Alvaro
2017-08-08
Bed bugs have reemerged recently as a serious and growing problem not only in North America but in many parts of the world. These insects have become the most challenging pest to control in urban environments. Residual insecticides are the most common methods used for bed bug control; however, insecticide resistance limits the efficacy of treatments. Desiccant dusts have emerged as a good option to provide a better residual effect for bed bug control. Several studies have focused on determining the efficacy of dust-based insecticides against bed bugs. However, behavioral responses of bed bugs to insecticide dusts could influence their efficacy. The behavioral responses of bed bugs to six insecticide dusts commonly used in the United States were evaluated with an advanced video tracking technique (Ethovision). Bed bugs took longer to make first contact with areas treated with the diatomaceous earth (DE)-based products MotherEarth D and Alpine than pyrethroid, pyrethrins or silica gel based products, DeltaDust, Tempo 1% Dust and CimeXa, respectively. Lower visitation rates of bed bugs were recorded for areas treated with MotherEarth D, Alpine and CimeXa than that of DeltaDust, Tempo 1% Dust, and Tri-Die Silica + Pyrethrum Dust. Bed bugs spent less time in areas treated with Tri-Die Dust, CimeXa, Alpine, and MotherEarth D than DeltaDust and Tempo 1% Dust, and they exhibited a reduction in locomotor parameters when crawling on areas treated with CimeXa and Alpine. The implications of these responses to bed bug control are discussed.
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Behavioral Responses of the Common Bed Bug, Cimex lectularius, to Insecticide Dusts
Agnew, John L.; Romero, Alvaro
2017-01-01
Bed bugs have reemerged recently as a serious and growing problem not only in North America but in many parts of the world. These insects have become the most challenging pest to control in urban environments. Residual insecticides are the most common methods used for bed bug control; however, insecticide resistance limits the efficacy of treatments. Desiccant dusts have emerged as a good option to provide a better residual effect for bed bug control. Several studies have focused on determining the efficacy of dust-based insecticides against bed bugs. However, behavioral responses of bed bugs to insecticide dusts could influence their efficacy. The behavioral responses of bed bugs to six insecticide dusts commonly used in the United States were evaluated with an advanced video tracking technique (Ethovision). Bed bugs took longer to make first contact with areas treated with the diatomaceous earth (DE)-based products MotherEarth D and Alpine than pyrethroid, pyrethrins or silica gel based products, DeltaDust, Tempo 1% Dust and CimeXa, respectively. Lower visitation rates of bed bugs were recorded for areas treated with MotherEarth D, Alpine and CimeXa than that of DeltaDust, Tempo 1% Dust, and Tri-Die Silica + Pyrethrum Dust. Bed bugs spent less time in areas treated with Tri-Die Dust, CimeXa, Alpine, and MotherEarth D than DeltaDust and Tempo 1% Dust, and they exhibited a reduction in locomotor parameters when crawling on areas treated with CimeXa and Alpine. The implications of these responses to bed bug control are discussed. PMID:28786920
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[Epizootiology of aegyptianellosis in poultry].
Tsanov, Ts S
1983-01-01
Epizootiologic studies were carried out on avian aegyptianellosis, especially with birds raised at poultry dressing combines and industrial poultry farms within the country. It was found that the mechanism of infection transmission was mediated not only by the role of Argas persicus ticks but also by bed bug insects of the Cimex genus, belonging to the Hemiptera order. Carriers of aegyptianellosis might also be migratory birds coming from tropical countries, such as swallows. It is concluded that avian aegyptianellosis can be referred to the group of the natural focal transmissive infections.
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Molecular Basis of Olfactory Chemoreception in the Common Bed Bug, Cimex lectularius.
Liu, Feng; Chen, Zhou; Liu, Nannan
2017-04-06
As one of the most notorious ectoparasites, bed bugs rely heavily on human or animal blood sources for survival, mating and reproduction. Chemoreception, mediated by the odorant receptors on the membrane of olfactory sensory neurons, plays a vital role in their host seeking and risk aversion processes. We investigated the responses of odorant receptors to a large spectrum of semiochemicals, including human odorants and plant-released volatiles and found that strong responses were sparse; aldehydes/ketones were the most efficient stimuli, while carboxylic acids and aliphatics/aromatics were comparatively less effective in eliciting responses from bed bug odorant receptors. In bed bugs, both the odorant identity and concentrations play important roles in determining the strength of these responses. The odor space constructed based on the responses from all the odorant receptors tested revealed that odorants within the same chemical group are widely dispersed while odorants from different groups are intermingled, suggesting the complexity of odorant encoding in the bed bug odorant receptors. This study provides a comprehensive picture of the olfactory coding mechanisms of bed bugs that will ultimately contribute to the design and development of novel olfactory-based strategies to reduce both the biting nuisance and disease transmission from bed bugs.
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Romero, Alvaro; Anderson, Troy D
2016-05-01
The rapid increase of bed bug populations resistant to pyrethroids demands the development of novel control tactics. Products combining pyrethroids and neonicotinoids have become very popular for bed bug control in the United States, but there are concerns about evolution of resistance to these compounds. Laboratory assays were used to measure the toxicity of topical applications of four neonicotinoids to a susceptible population and three pyrethroid-resistant populations. Activity of esterases, glutathione S-transferases, and cytochrome P450s of all strains was also evaluated. High levels of resistance to four neonicotinoids, acetamiprid, imidacloprid, dinotefuran, and thiamethoxam, relative to the susceptible Fort Dix population, were detected in populations collected from human dwellings in Cincinnati and Michigan. Because activity of detoxifying enzymes was increased in these two populations, our results suggest that these enzymes have some involvement in neonicotinoid resistance, but other resistance mechanisms might be involved as well. Detection of high levels of resistance to neonicotinoids further limits the options for chemical control of bed bugs. Published by Oxford University Press on behalf of Entomological Society of America 2016. This work is written by US Government employees and is in the public domain in the US.
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Kamimura, Yoshitaka; Mitsumoto, Hiroyuki; Lee, Chow-Yang
2014-01-01
During mating, male bed bugs (Cimicidae) pierce the female abdomen to inject sperm using their needle-like genitalia. Females evolved specialized paragenital organs (the spermalege and associated structures) to receive traumatically injected ejaculates. In Leptocimex duplicatus, the spermalege is duplicated, but the evolutionary significance of this is unclear. In Cimex hemipterus and C. lectularius, in which females normally develop a single spermalege on the right side of the abdomen, similar duplication sometimes occurs. Using these aberrant morphs (D-females) of C. hemipterus, we tested the hypothesis that both of the duplicated spermaleges are functionally competent. Scars on female abdominal exoskeletons indicated frequent misdirected piercing by male genitalia. However, the piercing sites showed a highly biased distribution towards the right side of the female body. A mating experiment showed that when the normal insemination site (the right-side spermalege) was artificially covered, females remained unfertilized. This was true even when females also had a spermalege on the left side (D-females). This result was attributed to handedness in male mating behavior. Irrespective of the observed disuse of the left-side spermalege by males for insemination, histological examination failed to detect any differences between the right-side and left-side spermaleges. Moreover, an artificial insemination experiment confirmed that spermatozoa injected into the left-side spermalege show apparently normal migration behavior to the female reproductive organs, indicating an evolutionary potential for functionally-competent duplicated spermaleges. We discuss possible mechanisms for the evolutionary maintenance of D-females and propose a plausible route to the functionally-competent duplicated spermaleges observed in L. duplicatus. PMID:24586643
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Mamidala, Praveen; Mittapelly, Priyanka; Jones, Susan C; Piermarini, Peter M; Mittapalli, Omprakash
2013-04-01
The molecular genetics of inward-rectifier potassium (Kir) channels in insects is poorly understood. To date, Kir channel genes have been characterized only from a few representative dipterans (i.e., fruit flies and mosquitoes). The goal of the present study was to characterize Kir channel cDNAs in a hemipteran, the bed bug (Cimex lectularius). Using our previously reported bed bug transcriptome (RNA-seq), we identified two cDNAs that encode putative Kir channels. One was a full-length cDNA that encodes a protein belonging to the insect 'Kir3' clade, which we designate as 'ClKir3'. The other was a partial cDNA that encodes a protein with similarity to both the insect 'Kir1' and 'Kir2' clades, which we designate as 'ClKir1/2'. Quantitative real-time PCR analysis revealed that ClKir1/2 and ClKir3 exhibited peak expression levels in late-instar nymphs and early-instar nymphs, respectively. Furthermore, ClKir3, but not ClKir1/2, showed tissue-specific expression in Malpighian tubules of adult bed bugs. Lastly, using an improved procedure for delivering double-stranded RNA (dsRNA) to male and female bed bugs (via the cervical membrane) we demonstrate rapid and systemic knockdown of ClKir3 transcripts. In conclusion, we demonstrate that the bed bug possesses at least two genes encoding Kir channels, and that RNAi is possible for at least Kir3, thereby offering a potential approach for elucidating the roles of Kir channel genes in bed bug physiology. Copyright © 2013 Elsevier Inc. All rights reserved.
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Talbot, Benoit; Vonhof, Maarten J; Broders, Hugh G; Fenton, Brock; Keyghobadi, Nusha
2018-05-01
Parasite-host relationships create strong selection pressures that can lead to adaptation and increasing specialization of parasites to their hosts. Even in relatively loose host-parasite relationships, such as between generalist ectoparasites and their hosts, we may observe some degree of specialization of parasite populations to one of the multiple potential hosts. Salivary proteins are used by blood-feeding ectoparasites to prevent hemostasis in the host and maximize energy intake. We investigated the influence of association with specific host species on allele frequencies of salivary protein genes in Cimex adjunctus, a generalist blood-feeding ectoparasite of bats in North America. We analysed two salivary protein genes: an apyrase, which hydrolyses ATP at the feeding site and thus inhibits platelet aggregation, and a nitrophorin, which brings nitrous oxide to the feeding site, inhibiting platelet aggregation and vasoconstriction. We observed more variation at both salivary protein genes among parasite populations associated with different host species than among populations from different spatial locations associated with the same host species. The variation in salivary protein genes among populations on different host species was also greater than expected under a neutral scenario of genetic drift and gene flow. Finally, host species was an important predictor of allelic divergence in genotypes of individual C. adjunctus at both salivary protein genes. Our results suggest differing selection pressures on these two salivary protein genes in C. adjunctus depending on the host species. © 2018 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2018 European Society For Evolutionary Biology.
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Bartonička, Tomáš; Růžičková, Lucie
2013-04-01
Roost ectoparasites are believed to have a negative impact on fitness of their hosts as birds or mammals. Previous studies were mostly focussed on the synchronization between reproduction cycles of ectoparasites and hosts living in infested roosts. However, to date, it has not been examined how fast ectoparasites colonize new, non-infested roosts and thus increasing the impact on the local populations of hosts. The parasite-host model was studied, including bat bugs Cimex pipistrelli and soprano pipistrelles Pipistrellus pygmaeus, where bat behaviour was observed which tended to reduce the parasite load in bat roosts. We investigated (1) whether bats change their roosting behaviour when we discontinued synchronization of their reproduction and the life cycle of the bat bugs and (2) how fast and which stages of bat bugs reoccupy cleaned roosts. In a 3-year field experiment, we removed all bat bugs from six bat boxes in each spring. Pipistrelles bred young in all non-infested boxes during these 3 years. In addition, 8 years of regular observations before this experiment indicate that bats avoided breeding in the same bat boxes at all. Bat bugs were found again in clean boxes in mid-May. However, their densities did not maximise before the beginning of June, before parturition. A re-appearance of bugs was observed after 21-56 days after the first bat visit. Adult bugs, mainly females, colonised cleaned boxes first though at the same time there were a lot of younger and smaller instars in non-manipulated roosts in the vicinity.
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Gujar, Hemant; Palli, Subba Reddy
2016-05-17
The common bed bug is an obligate hematophagous parasite of humans. We studied the regulation of molting and metamorphosis in bed bugs with a goal to identify key players involved. qRT-PCR studies on the expression of genes known to be involved in molting and metamorphosis showed high levels of Krüppel homolog 1 [Kr-h1, a transcription factor that plays key roles in juvenile hormone (JH) action] mRNA in the penultimate nymphal stage (N4). However, low levels of Kr-h1 mRNA were detected in the fifth and last nymphal stage (N5). Knockdown of Kr-h1 in N4 resulted in a precocious development of adult structures. Kr-h1 maintains the immature stage by suppressing E93 (early ecdysone response gene) in N4. E93 expression increases during the N5 in the absence of Kr-h1 and promotes the development of adult structures. Knockdown of E93 in N5 results in the formation of supernumerary nymphs. The role of JH in the suppression of adult structures through interaction with Kr-h1 and E93 was also studied by the topical application of JH analog, methoprene, to N5. Methoprene induced Kr-h1 and suppressed E93 and induced formation of the supernumerary nymph. These data show interactions between Kr-h1, E93 and JH in the regulation of metamorphosis in the bed bugs.
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Effect of Moxidectin on Bed Bug Feeding, Development, Fecundity, and Survivorship
Zha, Chen; Sheele, Johnathan Michael
2017-01-01
The common bed bug, Cimex lectularius L. (Hemiptera: Cimicidae), is a blood-feeding ectoparasite which experienced world-wide resurgence during recent decades. The control of bed bugs is often challenging, due to their cryptic nature and resistance to commonly used insecticides. In this study, we evaluated the effect of the antiparasitic drug moxidectin on bed bug survival, reproduction, and development. The LC50 (lethal concentration to kill half the members of a tested population) of moxidectin against bed bug male adults, female adults, and large nymphs were 52.7 (95% CI (confidence interval): 39.5–70.8), 29.3 (95% CI: 20.7–40.5), and 29.1 ng/mL (95% CI: 23.3–35.3), respectively. Moxidectin (≥ 25 ng/mL) reduced egg laying of bed bug females, but showed no significant effect on egg hatching. One time feeding on rabbit blood containing 20 and 40 ng/mL moxidectin showed no negative effects in bed bug feeding and blood meal ingestion, but significantly reduced digestion rates and nymph molting rates. Although moxidectin at concentrations of 20 and 40 ng/mL only caused moderate mortality in bed bugs, it significantly interrupted digestion, development, and oviposition of survived bed bugs for at least one week after feeding. Moxidectin is a promising supplement of the existing bed bug control materials if its use on humans can be approved in the future. PMID:28973981
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Gujar, Hemant; Palli, Subba Reddy
2016-01-01
The common bed bug is an obligate hematophagous parasite of humans. We studied the regulation of molting and metamorphosis in bed bugs with a goal to identify key players involved. qRT-PCR studies on the expression of genes known to be involved in molting and metamorphosis showed high levels of Krüppel homolog 1 [Kr-h1, a transcription factor that plays key roles in juvenile hormone (JH) action] mRNA in the penultimate nymphal stage (N4). However, low levels of Kr-h1 mRNA were detected in the fifth and last nymphal stage (N5). Knockdown of Kr-h1 in N4 resulted in a precocious development of adult structures. Kr-h1 maintains the immature stage by suppressing E93 (early ecdysone response gene) in N4. E93 expression increases during the N5 in the absence of Kr-h1 and promotes the development of adult structures. Knockdown of E93 in N5 results in the formation of supernumerary nymphs. The role of JH in the suppression of adult structures through interaction with Kr-h1 and E93 was also studied by the topical application of JH analog, methoprene, to N5. Methoprene induced Kr-h1 and suppressed E93 and induced formation of the supernumerary nymph. These data show interactions between Kr-h1, E93 and JH in the regulation of metamorphosis in the bed bugs. PMID:27185064
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Bed bug outbreak in a neonatal unit.
Bandyopadhyay, T; Kumar, A; Saili, A
2015-10-01
There has been a worldwide increase in bed bug infestations over the last 10-15 years. A major stigma is placed upon the institutions found to be infested. We report our experience with an outbreak of the tropical bed bug, Cimex hemipterus, in a neonatal unit. The outbreak not only affected the admitted newborns and mothers by causing a wide variety of rashes and inducing sleeplessness, but also impinged upon the health professionals and their families by producing similar symptomology. It is important for healthcare providers to be aware of, and for each healthcare facility to have, bed bug prevention and control policies.
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Bed bug dermatitis, description of two cases in Rio de Janeiro, Brazil.
Bernardes Filho, Fred; Quaresma, Maria Victória; Avelleira, João Carlos Regazzi; Azulay, David Rubem; Azulay-Abulafia, Luna; Bastos, Amanda Queiroz; Gonçalves, Teresa Cristina Monte
2015-01-01
Bed bugs are hematophagous insects which due to their morphological and biological characteristics are able to easily adapt themselves to human households. The authors describe two cases of dermatitis caused by bed bug bites in the city of Rio de Janeiro, Brazil. Patients presented linear lesions in the usual "breakfast, lunch and dinner" arrangement, suggesting this diagnosis. A visit to their dwellings showed infestation of insects identified as Cimex hemipterus. The knowledge of these insects by the dermatological community will contribute to an accurate diagnosis as well as subsidize the dissemination of information aiming for prevention.
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Bed bug dermatitis, description of two cases in Rio de Janeiro, Brazil*
Bernardes, Fred; Quaresma, Maria Victória; Avelleira, João Carlos Regazzi; Azulay, David Rubem; Azulay-Abulafia, Luna; Bastos, Amanda Queiroz; Gonçalves, Teresa Cristina Monte
2015-01-01
Bed bugs are hematophagous insects which due to their morphological and biological characteristics are able to easily adapt themselves to human households. The authors describe two cases of dermatitis caused by bed bug bites in the city of Rio de Janeiro, Brazil. Patients presented linear lesions in the usual "breakfast, lunch and dinner" arrangement, suggesting this diagnosis. A visit to their dwellings showed infestation of insects identified as Cimex hemipterus. The knowledge of these insects by the dermatological community will contribute to an accurate diagnosis as well as subsidize the dissemination of information aiming for prevention. PMID:25830996
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Ectoparasites in an urban population of big brown bats (Eptesicus fuscus) in Colorado
Pearce, R.D.; O'Shea, T.J.
2007-01-01
Ectoparasites of an urban population of big brown bats (Eptesicus fuscus) in Fort Collins, Colorado, were investigated during summers 2002, 2003, and 2004. Eleven species of ectoparasites were found (the macronyssid mite Steatonyssus occidentalis, the wing mite Spinturnix bakeri, the myobiid mites Acanthophthirius caudata and Pteracarus aculeus, the chirodiscid mite Alabidocarpus eptesicus, the demodicid mite Demodex sp., the chigger Leptotrombidium myotis, the soft tick Carios kelleyi, the batfly Basilia forcipata, the batbug Cimex pilosellus, and the flea Myodopsylla borealis). Five species were analyzed by prevalence and intensity (C. pilosellus, M. borealis, L. myotis, S. bakeri, and S. occidentalis) based on 2,161 counts of 1,702 marked individual bats over the 3 summer study periods. We investigated 4 factors potentially influencing prevalence and intensity: age class of the host, reproductive status of adult female hosts, roosts in which the hosts were found, and abiotic conditions during the year sampled. The macronyssid mite, S. occidentalis, was the most prevalent and abundant ectoparasite. Adult big brown bats had more ectoparasites than volant juveniles for most of the species analyzed. In a sample of known age bats at 1 large colony, bats of 4 yr of age or greater had higher ectoparasite loads of S. occidentalis and S. bakeri when compared with younger bats. Lactating female bats had the highest prevalence and intensities of most ectoparasites. Annual differences in ectoparasite prevalence and intensity were related to temperature and humidity, which can affect the nidicolous species of ectoparasites. Residents of 2 buildings sprayed insecticides in response to Cimex sp., and this appeared to reduce ectoparasitism of S. occidentalis and C. pilosellus present at these buildings. Intensity of S. occidentalis had no influence on annual survival of big brown bats. ?? American Society of Parasitologists 2007.
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Transcriptomics of the Bed Bug (Cimex lectularius)
Rajarapu, Swapna P.; Jones, Susan C.; Mittapalli, Omprakash
2011-01-01
Background Bed bugs (Cimex lectularius) are blood-feeding insects poised to become one of the major pests in households throughout the United States. Resistance of C. lectularius to insecticides/pesticides is one factor thought to be involved in its sudden resurgence. Despite its high-impact status, scant knowledge exists at the genomic level for C. lectularius. Hence, we subjected the C. lectularius transcriptome to 454 pyrosequencing in order to identify potential genes involved in pesticide resistance. Methodology and Principal Findings Using 454 pyrosequencing, we obtained a total of 216,419 reads with 79,596,412 bp, which were assembled into 35,646 expressed sequence tags (3902 contigs and 31744 singletons). Nearly 85.9% of the C. lectularius sequences showed similarity to insect sequences, but 44.8% of the deduced proteins of C. lectularius did not show similarity with sequences in the GenBank non-redundant database. KEGG analysis revealed putative members of several detoxification pathways involved in pesticide resistance. Lamprin domains, Protein Kinase domains, Protein Tyrosine Kinase domains and cytochrome P450 domains were among the top Pfam domains predicted for the C. lectularius sequences. An initial assessment of putative defense genes, including a cytochrome P450 and a glutathione-S-transferase (GST), revealed high transcript levels for the cytochrome P450 (CYP9) in pesticide-exposed versus pesticide-susceptible C. lectularius populations. A significant number of single nucleotide polymorphisms (296) and microsatellite loci (370) were predicted in the C. lectularius sequences. Furthermore, 59 putative sequences of Wolbachia were retrieved from the database. Conclusions To our knowledge this is the first study to elucidate the genetic makeup of C. lectularius. This pyrosequencing effort provides clues to the identification of potential detoxification genes involved in pesticide resistance of C. lectularius and lays the foundation for future functional genomics studies. PMID:21283830
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Host association drives genetic divergence in the bed bug, Cimex lectularius.
Booth, Warren; Balvín, Ondřej; Vargo, Edward L; Vilímová, Jitka; Schal, Coby
2015-03-01
Genetic differentiation may exist among sympatric populations of a species due to long-term associations with alternative hosts (i.e. host-associated differentiation). While host-associated differentiation has been documented in several phytophagus insects, there are far fewer cases known in animal parasites. The bed bug, Cimex lectularius, a wingless insect, represents a potential model organism for elucidating the processes involved in host-associated differentiation in animal parasites with relatively limited mobility. In conjunction with the expansion of modern humans from Africa into Eurasia, it has been speculated that bed bugs extended their host range from bats to humans in their shared cave domiciles throughout Eurasia. C. lectularius that associate with humans have a cosmopolitan distribution, whereas those associated with bats occur across Europe, often in human-built structures. We assessed genetic structure and gene flow within and among populations collected in association with each host using mtDNA, microsatellite loci and knock-down resistance gene variants. Both nuclear and mitochondrial data support a lack of significant contemporary gene flow between host-specific populations. Within locations human-associated bed bug populations exhibit limited genetic diversity and elevated levels of inbreeding, likely due to human-mediated movement, infrequent additional introduction events per infestation, and pest control. In contrast, populations within bat roosts exhibit higher genetic diversity and lower levels of relatedness, suggesting populations are stable with temporal fluctuations due to host dispersal and bug mortality. In concert with previously published evidence of morphological and behavioural differentiation, the genetic data presented here suggest C. lectularius is currently undergoing lineage divergence through host association. © 2015 John Wiley & Sons Ltd.
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DeVries, Zachary C.; Reid, William R.; Kells, Stephen A.; Appel, Arthur G.
2015-01-01
Bed bugs, Cimex lectularius L., are a major pest in the urban environment. Their presence often results in physical, psychological, and financial distress of homeowners and apartment dwellers. Although many insecticide bioassays have been performed on this pest, little attention has been paid to bed bug feeding status, which is closely linked to metabolism, molting, and mass. Therefore, we evaluated the toxicity of topically applied deltamethrin on insecticide susceptible adult male bed bugs fed 2 d, 9 d, and 21 d prior to testing. When toxicity was evaluated on a “per-bug” basis, there was no difference between 2 d [LD50 = 0.498 (0.316 − 0.692) ng·bug−1] and 9 d [LD50 = 0.572 (0.436 − 0.724) ng·bug−1] starved bugs, while 21 d starved bugs had a significantly lower LD50 [0.221 (0.075 − 0.386) ng·bug−1]. When toxicity was evaluated in terms of body mass, 9 d starved bugs had the highest LD50 values [0.138 (0.102 − 0.176) ng·mg−1], followed by 2 d starved bugs [0.095 (0.060 − 0.134) ng·mg−1], and then 21 d starved bugs [0.058 (0.019–0.102) ng·mg−1]; the LD50 values of 2 d and 9 d starved bugs were significantly different from 21 d starved bugs. These results indicate that feeding status plays an important role in the toxicity of deltamethrin. In addition, the lack of differences between 2 d and 9 d starved bugs indicate that the blood meal itself has little impact on tolerance, but rather it is some physiological change following feeding that confers increased tolerance to bed bugs. PMID:26463068
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Seri Masran, Siti Nor Ain; Ab Majid, Abdul Hafiz
2017-07-01
The tropical bed bug is scientifically recognized as a significant public health problem. While there is an increased awareness about their resurgence by medical and life science committees, efficient bed bug management still remains unresolved. The solution may soon arise, as information about bed bugs' infestation dynamics and systematics are becoming more distinguishable. Recent developments in studies about bed bugs are based on molecular intervention by determining their genetic variation and phylogeography. The aim of this study is to assess the phylogenetic relationships and genetic diversity among the populations of tropical bed bugs inhabiting Malaysia. A molecular genotyping study was conducted with 22 tropical bed bug populations composed of three individuals per population. The mitochondrial (COI) gene was used as a marker. The data obtained were analyzed using the T-Coffee, ClustalX, MEGA 6.0, and PAUP software. The results showed one main monophyletic clade that consisted of two groups: Ch01 and Ch02. Ch02 consists of samples from the Bandar Hilir population, differing from the other populations studied by one singleton base. However, as there were no changes in the amino acid, this singleton genetic variation was considered to have no effect on genetic differentiation. Ch01 shows similarity with some sequence of Cimex hemipterus (F.) from Thailand, suggesting an international diversity connection. The disparity index apparently suggests that all isolates are homogeneous populations and are supported by the low value of the mean pairwise distance between isolates. This study will increase the knowledge about phylogeographic diversity of tropical bed bug in Malaysia. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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Wang, Changlu; Singh, Narinderpal; Cooper, Richard
2015-03-18
Three insecticide mixtures that contain two classes of insecticides (pyrethroid and neonicotinoid) were recently developed to control bed bugs. We evaluated three integrated bed bug management strategies in apartments, each using the same non-chemical control methods and one of the three insecticide mixture products: Tandem (lambda-cyhalothrin + thiamethoxam), Temprid SC (beta-cyfluthrin + imidacloprid), and Transport Mikron (bifenthrin + acetamiprid). No insecticides were applied in the Control apartments. In all apartments, we installed vinyl mattress encasements (if not already present) and applied steam to beds and other infested upholstered furniture. Insecticide sprays were applied in the three treatments. Each treatment and the Control included 8-10 occupied apartments. Re-treatment was conducted during biweekly inspections if necessary. After eight weeks, the mean (± SEM) bed bug count reduction in the Tandem, Temprid SC, Transport Mikron, and Control was 89 ± 9, 87 ± 6, 98 ± 1, and 23 ± 54%, respectively. Only Tandem and Transport Mikron treatments resulted in significantly higher population reduction than the Control at eight weeks. There were no significant differences in mean percent reduction among the three treatments (Tandem, Temprid SC, Transport Mikron) at eight weeks. Tandem spray caused significantly faster bed bug reduction than Temprid SC spray and Transport Mikron spray.
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Molecular Basis of Olfactory Chemoreception in the Common Bed Bug, Cimex lectularius
Liu, Feng; Chen, Zhou; Liu, Nannan
2017-01-01
As one of the most notorious ectoparasites, bed bugs rely heavily on human or animal blood sources for survival, mating and reproduction. Chemoreception, mediated by the odorant receptors on the membrane of olfactory sensory neurons, plays a vital role in their host seeking and risk aversion processes. We investigated the responses of odorant receptors to a large spectrum of semiochemicals, including human odorants and plant-released volatiles and found that strong responses were sparse; aldehydes/ketones were the most efficient stimuli, while carboxylic acids and aliphatics/aromatics were comparatively less effective in eliciting responses from bed bug odorant receptors. In bed bugs, both the odorant identity and concentrations play important roles in determining the strength of these responses. The odor space constructed based on the responses from all the odorant receptors tested revealed that odorants within the same chemical group are widely dispersed while odorants from different groups are intermingled, suggesting the complexity of odorant encoding in the bed bug odorant receptors. This study provides a comprehensive picture of the olfactory coding mechanisms of bed bugs that will ultimately contribute to the design and development of novel olfactory-based strategies to reduce both the biting nuisance and disease transmission from bed bugs. PMID:28383033
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Wang, Changlu; Singh, Narinderpal; Cooper, Richard
2015-01-01
Three insecticide mixtures that contain two classes of insecticides (pyrethroid and neonicotinoid) were recently developed to control bed bugs. We evaluated three integrated bed bug management strategies in apartments, each using the same non-chemical control methods and one of the three insecticide mixture products: Tandem (lambda-cyhalothrin + thiamethoxam), Temprid SC (beta-cyfluthrin + imidacloprid), and Transport Mikron (bifenthrin + acetamiprid). No insecticides were applied in the Control apartments. In all apartments, we installed vinyl mattress encasements (if not already present) and applied steam to beds and other infested upholstered furniture. Insecticide sprays were applied in the three treatments. Each treatment and the Control included 8–10 occupied apartments. Re-treatment was conducted during biweekly inspections if necessary. After eight weeks, the mean (± SEM) bed bug count reduction in the Tandem, Temprid SC, Transport Mikron, and Control was 89 ± 9, 87 ± 6, 98 ± 1, and 23 ± 54%, respectively. Only Tandem and Transport Mikron treatments resulted in significantly higher population reduction than the Control at eight weeks. There were no significant differences in mean percent reduction among the three treatments (Tandem, Temprid SC, Transport Mikron) at eight weeks. Tandem spray caused significantly faster bed bug reduction than Temprid SC spray and Transport Mikron spray. PMID:26463075
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Basnet, Sanjay; Kamble, Shripat T
2018-05-04
The common bed bug, Cimex lectularius L. (Hemiptera: Cimicidae) has resurged as one of the most troublesome household pests affecting people across the globe. Bed bug infestations have increased in recent years primarily due to the evolution of insecticide resistance and the insect's ability to hitchhike with travelers. vATPases are one of the most evolutionarily conserved holoenzymes in eukaryotes, which are mainly involved in proton transport across the plasma membranes and intracellular organelles. RNA interference (RNAi) has been developed as a promising tool for insect control. In this study, we used RNAi as an approach to knock down subunits A and E of the vATPase gene of bed bugs. Delivery of 0.2 µg/insect of dsRNA specific to vATPase-A and vATPase-E into female bed bugs dramatically impaired the laying and viability of eggs over time. Injection of the vATPase-E dsRNA decreased survival of the bed bugs over 30 d. Our results also showed that the knockdown of mRNA is highly effective and persistent up to 30 d post injection. This research demonstrated that silencing of the two vATPase subunits A and E offers a potential strategy to suppress bed bug populations.
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Application of native prick test in diagnosis of bed bug allergy.
Ukleja-Sokołowska, Natalia; Sokołowski, Lukasz; Gawrońska-Ukleja, Ewa; Bartuzi, Zbigniew
2013-02-01
The aim of the study was case report of the patient with systemic reaction after a bed bug (Cimex lectularius) bite. A 23-year-old female, previously healthy, reports systemic reaction, including rash on her corpus and limbs, itching, nausea, conciseness disorder, forcing her to call the ambulance. The interview revealed that the bed bug occurs in the patient's apartment. A prick-by-prick test with bed bug excretion was made. The skin test with native allergen was strongly positive (histamine 5 mm/5 mm, prick-by-prick 12 mm/8 mm). The prick-by-prick test was useful in objective confirmation of the source of symptoms.
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Cimex lectularius ("Bed Bugs"): Recognition, Management, and Eradication.
McMenaman, Kathryn S; Gausche-Hill, Marianne
2016-11-01
Reports of bed bug infestations in major cities in the United States and abroad have been in the public press. Physicians and other clinicians who care for children need to be able to recognize bed bug bites and understand the social, psychological, and medical implications that this diagnosis will have on patients and their families. In this article, a case presentation serves to guide discussion regarding establishing the diagnosis, differential diagnosis, and the management of bed bug bites and their complications. Integrated pest management programs involving housing managers, residents, and professional pest exterminators provide both chemical and nonchemical solutions for eradication of bed bug infestations.
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A preliminary evaluation of the potential of Beauveria bassiana for bed bug control.
Barbarin, Alexis M; Jenkins, Nina E; Rajotte, Edwin G; Thomas, Matthew B
2012-09-15
Residual biopesticide treatments of Beauveria bassiana were tested against the bed bug Cimex lectularius. An oil formulation of conidia was applied to different substrates. Bed bugs were exposed for 1 h, transferred to an unsprayed environment and monitored for mortality. Separate bioassays evaluated the effect of bed bug strain, sex, life stage, and exposure substrate on mortality. Rapid mortality was observed in all bioassays, with bed bugs exposed to treated jersey knit cotton dying most rapidly. A further assay demonstrated efficient autodissemination of conidia from exposed bed bugs to unexposed bed bugs within artificial harborages. Copyright © 2012 Elsevier Inc. All rights reserved.
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The Interface Among Poverty, Air Mattress Industry Trends, Policy, and Infant Safety.
Doering, Jennifer J; Salm Ward, Trina C
2017-06-01
Infants can suffocate on air mattresses, even when the mattress is fully inflated. The interfacing issues of poverty, the bedbug epidemic, and changes in the design and marketing of air mattresses may be increasing consumer use of air mattresses as primary sleep environments and thus increasing the potential for infant death. Despite recent changes to improve air mattress safety labeling, the National Child Death Review Case Reporting System found that between 2004 and 2015 across 24 states, an air mattress was the incident sleep place for 108 infants whose deaths were either during sleep or in a sleep environment. At the same time, design components such as inflatable headboards and memory foam pillow tops potentially increase the hazard to infants, and marketing changes represent air mattresses as a preferred low-cost primary sleep environment. Analysis of current data surveillance systems, published position statements, and consumer materials from national organizations and federal agencies reveal opportunities for changing policy to better protect infants from this hazard.
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Repellency of selected chemicals against the bed bug (Hemiptera: Cimicidae).
Wang, Changlu; Lü, Lihua; Zhang, Aijun; Liu, Chaofeng
2013-12-01
In recent years, the common bed bug, Cimex lectularius L. (Hemiptera: Cimicidae), became a major public health concern in urban communities. Bed bugs are notoriously difficult to control, and their bites are not tolerated by most people. The public has an urgent need for materials and methods to reduce bed bug introduction and bites during work, travel, or sleep. A repellent product will help achieve these goals by discouraging and preventing bed bugs from moving to a protected area. We evaluated the repellency of three commercially available insect repellent or control materials and five nonregistered materials with the goal of identifying safe and effective bed bug repellents. The two commercial repellent products that contained 7% picaridin or 0.5% permethrin had little repellency against bed bugs. N,N-diethyl-m-toluamide (DEET), the most commonly used insect repellent, provided a high level of repellency against bed bugs. When a host cue (carbon dioxide) was present, the minimum DEET concentration to repel > or = 94% of the bed bugs for a9-h period was 10%. The longevity of repellency of DEET was concentration dependent. At 25% concentration, DEET-treated fabric surface remained highly repellent to bed bugs for a 14-d period. However, DEET has a strong smell and dissolves certain plastic materials. Therefore, we evaluated several odorless, noncorrosive, and potentially effective repellents. Isolongifolenone and isolongifolanone, two natural products and recently reported insect repellents, exhibited strong repellent property against bed bugs but at significantly lower levels than DEET. Three novel potential repellent compounds discovered by Bedoukian Research Inc. (Danbury, CT) exhibited similar level of repellency and longevity as DEET for repelling bed bugs. These nonirritant and odorless compounds are promising candidates as alternatives to DEET for reducing the spread of bed bugs and bed bug bites.
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Evidence for Metabolic Pyrethroid Resistance in the Common Bed Bug (Hemiptera: Cimicidae).
Lilly, David G; Dang, Kai; Webb, Cameron E; Doggett, Stephen L
2016-03-27
Resistance to insecticides, especially the pyrethroids, in the common bed bug,Cimex lectulariusL., has been well-documented. However, the presence and relative contribution of metabolic detoxifying microsomal oxidases and hydrolytic esterases to the observed resistance has yet to be fully elucidated. This is due, in part, to the absence of a simple bioassay procedure that appropriately isolates esterases from potentially competing oxidases. Recently, an analogue of piperonyl butoxide (PBO) was developed, EN16/5-1 (6-[2-(2-butoxyethoxy) ethoxymethyl]-5-propyl-2,3-dihydrobenzofuranby), which inhibits esterases but has limited efficacy against the oxidases, whereas PBO inhibits both. The opportunity is now available to use both synergists via established bioassay methodologies and to screen for the potential presence of oxidase- or esterase-derived pyrethroid resistance in insecticide-resistant insects, including bed bugs. In the present study, EN16/5-1 and PBO were assayed in conjunction with deltamethrin against four field strains ofC. lectulariuscollected from independent geographic locations across Australia. All strains expressed a high degree of resistance to deltamethrin and significant inhibition of the observed resistance with preexposure to PBO. Nonsignificant differences between the cumulative mortality values for PBO and EN16/5-1 were then observed in two of the four bed bug strains, which indicate that detoxifying esterases are conferring substantially to the observed resistance in those strains. This study is the first to provide evidence that metabolic detoxification in the form of both hydrolytic esterases and microsomal oxidases is a major contributing factor to pyrethroid resistance inC. lectularius. © The Authors 2016. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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Climbing Ability of the Common Bed Bug (Hemiptera: Cimicidae).
Hottel, B A; Pereira, R M; Gezan, S A; Qing, R; Sigmund, W M; Koehler, P G
2015-05-01
Little is known about what factors influence the climbing ability of bed bugs, Cimex lectularius L. (Hemiptera: Cimicidae), in relation to the various surfaces they encounter. We examined how sex, time since last fed, and what surfaces the bed bugs were in contact with affected their climbing performance. The effects of sex and time since fed were tested by counting the number of bed bugs able to climb a 45° slope. The pulling force was recorded using an analytical balance technique that captured the sequential vertical pulling force output of bed bugs attached to various surfaces. Recently fed female bed bugs were found to have the most difficulty in climbing smooth surfaces in comparison with males. This difference can be explained by the larger weight gained from bloodmeals by female bed bugs. A variety of vertical pulling forces were observed on surfaces ranging from sandpaper to talc powder-covered glass. For surfaces not treated with talc powder, bed bugs generated the least amount of vertical pulling force from synthetically created 0.6-µm plastron surfaces. This vast range in the ability of bed bugs to grip onto various surfaces may have implications on limiting bed bugs dispersal and hitchhiking behaviors. © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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The Odorant Receptor Co-Receptor from the Bed Bug, Cimex lectularius L
Hansen, Immo A.; Rodriguez, Stacy D.; Drake, Lisa L.; Price, David P.; Blakely, Brittny N.; Hammond, John I.; Tsujimoto, Hitoshi; Monroy, Erika Y.; Maio, William A.; Romero, Alvaro
2014-01-01
Recently, the bed bug, Cimex lectularius L. has re-emerged as a serious and growing problem in many parts of the world. Presence of resistant bed bugs and the difficulty to eliminate them has renewed interest in alternative control tactics. Similar to other haematophagous arthropods, bed bugs rely on their olfactory system to detect semiochemicals in the environment. Previous studies have morphologically characterized olfactory organs of bed bugs’ antenna and have physiologically evaluated the responses of olfactory receptor neurons (ORNs) to host-derived chemicals. To date, odorant binding proteins (OBPs) and odorant receptors (ORs) associated with these olfaction processes have not been studied in bed bugs. Chemoreception in insects requires formation of heteromeric complexes of ORs and a universal OR coreceptor (Orco). Orco is the constant chain of every odorant receptor in insects and is critical for insect olfaction but does not directly bind to odorants. Orco agonists and antagonists have been suggested as high-value targets for the development of novel insect repellents. In this study, we have performed RNAseq of bed bug sensory organs and identified several odorant receptors as well as Orco. We characterized Orco expression and investigated the effect of chemicals targeting Orco on bed bug behavior and reproduction. We have identified partial cDNAs of six C. lectularius OBPs and 16 ORs. Full length bed bug Orco was cloned and sequenced. Orco is widely expressed in different parts of the bed bug including OR neurons and spermatozoa. Treatment of bed bugs with the agonist VUAA1 changed bed bug pheromone-induced aggregation behavior and inactivated spermatozoa. We have described and characterized for the first time OBPs, ORs and Orco in bed bugs. Given the importance of these molecules in chemoreception of this insect they are interesting targets for the development of novel insect behavior modifiers. PMID:25411789
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The odorant receptor co-receptor from the bed bug, Cimex lectularius L.
Hansen, Immo A; Rodriguez, Stacy D; Drake, Lisa L; Price, David P; Blakely, Brittny N; Hammond, John I; Tsujimoto, Hitoshi; Monroy, Erika Y; Maio, William A; Romero, Alvaro
2014-01-01
Recently, the bed bug, Cimex lectularius L. has re-emerged as a serious and growing problem in many parts of the world. Presence of resistant bed bugs and the difficulty to eliminate them has renewed interest in alternative control tactics. Similar to other haematophagous arthropods, bed bugs rely on their olfactory system to detect semiochemicals in the environment. Previous studies have morphologically characterized olfactory organs of bed bugs' antenna and have physiologically evaluated the responses of olfactory receptor neurons (ORNs) to host-derived chemicals. To date, odorant binding proteins (OBPs) and odorant receptors (ORs) associated with these olfaction processes have not been studied in bed bugs. Chemoreception in insects requires formation of heteromeric complexes of ORs and a universal OR coreceptor (Orco). Orco is the constant chain of every odorant receptor in insects and is critical for insect olfaction but does not directly bind to odorants. Orco agonists and antagonists have been suggested as high-value targets for the development of novel insect repellents. In this study, we have performed RNAseq of bed bug sensory organs and identified several odorant receptors as well as Orco. We characterized Orco expression and investigated the effect of chemicals targeting Orco on bed bug behavior and reproduction. We have identified partial cDNAs of six C. lectularius OBPs and 16 ORs. Full length bed bug Orco was cloned and sequenced. Orco is widely expressed in different parts of the bed bug including OR neurons and spermatozoa. Treatment of bed bugs with the agonist VUAA1 changed bed bug pheromone-induced aggregation behavior and inactivated spermatozoa. We have described and characterized for the first time OBPs, ORs and Orco in bed bugs. Given the importance of these molecules in chemoreception of this insect they are interesting targets for the development of novel insect behavior modifiers.
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BENOIT, JOSHUA B.; PHILLIPS, SETH A.; CROXALL, TRAVIS J.; CHRISTENSEN, BRADY S.; YODER, JAY A.; DENLINGER, DAVID L.
2009-01-01
We demonstrate that the addition of bed bug, Cimex lectularius, alarm pheromone to desiccant formulations greatly enhances their effectiveness during short-term exposure. Two desiccant formulations, diatomaceous earth (DE) and Dri-die (silica gel), were applied at the label rate with and without bed bug alarm pheromone components, (E)-2-hexenal, (E)-2-octenal, and a (E)-2-hexenal:(E)-2-octenal blend. First-instar nymphs and adult females were subjected to 10-min exposures, and water loss rates were used to evaluate the response. Optimal effectiveness was achieved with a pheromone concentration of 0.01 M. With Dri-die alone, the water loss was 21% higher than in untreated controls, and water loss increased nearly two times with (E)-2-hexenal and (E)-2-octenal and three times with the (E)-2-hexenal: (E)-2-octenal blend. This shortened survival of first-instar nymphs from 4 to 1 d, with a similar reduction noted in adult females. DE was effective only if supplemented with pheromone, resulting in a 50% increase in water loss over controls with the (E)-2-hexenal:(E)-2-octenal blend, and a survival decrease from 4 to 2 d in first-instar nymphs. Consistently, the addition of the pheromone blend to desiccant dust was more effective than adding either component by itself or by using Dri-die or DE alone. Based on observations in a small microhabitat, the addition of alarm pheromone components prompted bed bugs to leave their protective harborages and to move through the desiccant, improving the use of desiccants for control. We concluded that short exposure to Dri-die is a more effective treatment against bed bugs than DE and that the effectiveness of the desiccants can be further enhanced by incorporation of alarm pheromone. Presumably, the addition of alarm pheromone elevates excited crawling activity, thereby promoting cuticular changes that increase water loss. PMID:19496429
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Goodall, Catherine E; Reed, Phillip
2013-01-01
An experiment was conducted from the perspective of the Extended Parallel Process Model (EPPM) investigating readers' responses to print news stories about the issue of bed bugs. Stories containing reference to (a) the threat of bed bugs and (b) efficacy of the solution were manipulated to vary the level of certainty with which the variables were discussed. Results suggest that stories referencing uncertainty regarding presence of the bed-bug threat may be more likely to motivate intention to seek information than stories referencing certainty of the threat. Results also suggest that stories referencing uncertainty regarding feasibility/effectiveness of proposed solutions may be more likely to motivate intention to avoid information than stories referencing certainty of proposed solutions. Given that information avoidance is one of various types of maladaptive responses to fear appeal messages (according to EPPM), results suggest that the presence of uncertainty when discussing solutions to threats in news stories might result in problematic avoidance responses that discourage people from taking protective action.
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Sheele, J M; Barrett, E; Dash, D; Ridge, G E
2017-11-01
Little is known about the epidemiology of bed bugs within the healthcare system, but nymphal stages predominate in natural infestations. This study determined the life stages of bed bugs captured within a medical centre, and found that older bed bugs were more likely to be captured than younger insects. The numbers of first instars, third-fifth instars and adult females captured were significantly different compared with the numbers of each life stage found in a natural infestation (P<0.01). A significant number of early-instar bed bugs introduced into the medical centre may go unnoticed by hospital staff. Copyright © 2017 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
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Narain, Ralph B; Lalithambika, Sreedevi; Kamble, Shripat T
2015-07-01
With the recent global resurgence of the bed bugs (Cimex lectularius L.), there is a need to better understand its biology, ecology, and ability to establish populations. Bed bugs are domestic pests that feed mainly on mammalian blood. Although bed bugs have not been implicated as vectors of pathogens, their biting activity inflicts severe insomnia and allergic reactions. Moreover, they have recently developed resistance to various insecticides, which requires further molecular research to determine genetic variation and appropriate interventions. Population dynamics, including genetic differentiation and genetic distance of 10 populations from the Midwest were analyzed in this study. The bed bug samples collected by pest control companies were genotyped using eight species-specific microsatellite markers. Results showed all eight markers were polymorphic, with 8-16 alleles per locus, suggesting high genetic diversity. The FST values were >0.25, signifying pronounced genetic differentiation. The G-test results also indicated high genetic differentiation among populations. The frequency of the most common allele across all eight loci was 0.42. The coefficient of relatedness between each of the populations was >0.5, indicative of sibling or parent-offspring relationships, while the FIS and its confidence interval values were statistically insignificant within the populations tested. The populations departed from Hardy-Weinberg equilibrium, possibly because of high heterozygosity. The genetic distance analysis using a neighbor-joining tree showed that the populations from Kansas City, MO, were genetically separate from most of those from Nebraska, indicating a geographic pattern of genetic structure. Our study demonstrated the effectiveness of using microsatellite markers to study bed bugs population structure, thereby improving our understanding of bed bug population dynamics in the Midwest. Overall, this study showed a high genetic diversity and identified several new alleles in the bed bug populations in the Midwest. © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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Rukke, Bjørn Arne; Sivasubramaniam, Ranjeni; Birkemoe, Tone; Aak, Anders
2018-01-01
Sublethal heat stress may weaken bed bug infestations to potentially ease control. In the present study, experimental populations exposed to 34, 36 or 38°C for 2 or 3 weeks suffered significant mortality during exposure. Among survivors, egg production, egg hatching, moulting success and offspring proliferation decreased significantly in the subsequent 7 week recovery period at 22°C. The overall population success was negatively impacted by increasing temperature and duration of the stress. Such heat stress is inadequate as a single tool for eradication, but may be included as a low cost part of an integrated pest management protocol. Depending on the time available and infestation conditions, the success of some treatments can improve if sublethal heat is implemented prior to the onset of more conventional pest control measures.
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Rukke, Bjørn Arne; Sivasubramaniam, Ranjeni; Birkemoe, Tone; Aak, Anders
2018-01-01
Sublethal heat stress may weaken bed bug infestations to potentially ease control. In the present study, experimental populations exposed to 34, 36 or 38°C for 2 or 3 weeks suffered significant mortality during exposure. Among survivors, egg production, egg hatching, moulting success and offspring proliferation decreased significantly in the subsequent 7 week recovery period at 22°C. The overall population success was negatively impacted by increasing temperature and duration of the stress. Such heat stress is inadequate as a single tool for eradication, but may be included as a low cost part of an integrated pest management protocol. Depending on the time available and infestation conditions, the success of some treatments can improve if sublethal heat is implemented prior to the onset of more conventional pest control measures. PMID:29538429
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Group living accelerates bed bug (Hemiptera: Cimicidae) development.
Saenz, Virna L; Santangelo, Richard G; Vargo, Edward L; Schal, Coby
2014-01-01
For many insect species, group living provides physiological and behavioral benefits, including faster development. Bed bugs (Cimex lectularius L.) live in aggregations composed of eggs, nymphs, and adults of various ages. Our aim was to determine whether bed bug nymphs reared in groups develop faster than solitary nymphs. We reared first instars either in isolation or in groups from hatching to adult emergence and recorded their development time. In addition, we investigated the effects of group housing on same-age nymphs versus nymphs reared with adults. Nymphal development was 2.2 d faster in grouped nymphs than in solitary-housed nymphs, representing 7.3% faster overall development. However, this grouping effect did not appear to be influenced by group composition. Thus, similar to other gregarious insect species, nymph development in bed bugs is faster in aggregations than in isolation.
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Zha, Chen; Wang, Changlu; Buckley, Brian; Yang, Ill; Wang, Desen; Eiden, Amanda L; Cooper, Richard
2018-04-02
Pest infestations in residential buildings are common, but community-wide pest survey data are lacking. Frequent insecticide applications for controlling indoor pests leave insecticide residues and pose potential health risks to residents. In this study, a community-wide pest survey was carried out in a housing complex consisting of 258 units in 40 buildings in New Brunswick, New Jersey. It was immediately followed by implementation of an integrated pest management (IPM) program in all the cockroach-infested apartments and two bed bug apartments with the goal of eliminating pest infestations, reducing pyrethroid residues, and increasing resident satisfaction with pest control services. The IPM-treated apartments were revisited and treated biweekly or monthly for 7 mo. Initial inspection found the top three pests and their infestation rates to be as follows: German cockroaches (Blattella germanica L. [Blattodea: Blattellidae]), 28%; rodents, 11%; and bed bugs (Cimex lectularius L. [Hemiptera: Cimicidae]), 8%. Floor wipe samples were collected in the kitchens and bedrooms of 20 apartments for pyrethroid residue analysis before the IPM implementation; 17 of the 20 apartments were resampled again at 7 mo. The IPM program reduced cockroach counts per apartment by 88% at 7 wk after initial treatment. At 7 mo, 85% of the cockroach infestations found in the initial survey were eliminated. The average number of pyrethroids detected decreased significantly from 6 ± 1 (mean ± SEM) and 5 ± 1 to 2 ± 1 and 3 ± 1 in the kitchens and bedrooms, respectively. The average concentrations of targeted pyrethroids residue also decreased significantly in the kitchens and bedrooms.
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Population Growth Potential of the Bed Bug, Cimex lectularius L.: A Life Table Analysis
Polanco, Andrea M.; Brewster, Carlyle C.; Miller, Dini M.
2011-01-01
Experimental life tables were constructed and analyzed for three strains of the common bed bug: a pyrethroid-susceptible laboratory strain (HS), a highly resistant field strain (RR), and a field strain with a declining level of resistance (KR). Egg to adult survival in the RR strain was 94% compared with 79% and 69% in the HS and KR strains, respectively. The RR strain also developed significantly faster from egg to adult (∼35 days) than the other two strains (∼40 days). Analysis of a survivorship and fecundity life table for the RR strain produced the following results. The average life expectancy for a newly laid egg was ∼143 days, and that of a newly molted adult was ∼127 days. Females produced an average of 0.64 daughter eggs/day with the highest weekly production during the fifth week of adult life. Analysis of daily reproductive parity showed that females produced 1–3 and 4–6 eggs on 79 and 21% of the days, respectively, when egg laying occurred. The net reproductive rate (R0) of the RR strain was ∼35, which represents a 35-fold increase in the population per generation (∼92 days). The intrinsic rate of increase, r, was 0.054 indicating that the population multiplies 1.1 times/female/day (λ) and doubles in size every 13 days. The stable age distribution (cx) was dominated by nymphs (54%), followed by eggs (34%) and adults (12%). Reproductive values (vx) for the strain increased from egg to the adult stage. PMID:26467620
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Campbell, Brittany E; Miller, Dini M
2017-03-15
Standard toxicity evaluations of insecticides against insect pests are primarily conducted on adult insects. Evaluations are based on a dose-response or concentration-response curve, where mortality increases as the dose or concentration of an insecticide is increased. Standard lethal concentration (LC50) and lethal dose (LD50) tests that result in 50% mortality of a test population can be challenging for evaluating toxicity of insecticides against non-adult insect life stages, such as eggs and early instar or nymphal stages. However, this information is essential for understanding insecticide efficacy in all bed bug life stages, which affects control and treatment efforts. This protocol uses a standard dipping bioassay modified for bed bug eggs and a contact insecticidal assay for treating nymphal first instars. These assays produce a concentration-response curve to further quantify LC50 values for insecticide evaluations.
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Unique features of a global human ectoparasite identified through sequencing of the bed bug genome.
Benoit, Joshua B; Adelman, Zach N; Reinhardt, Klaus; Dolan, Amanda; Poelchau, Monica; Jennings, Emily C; Szuter, Elise M; Hagan, Richard W; Gujar, Hemant; Shukla, Jayendra Nath; Zhu, Fang; Mohan, M; Nelson, David R; Rosendale, Andrew J; Derst, Christian; Resnik, Valentina; Wernig, Sebastian; Menegazzi, Pamela; Wegener, Christian; Peschel, Nicolai; Hendershot, Jacob M; Blenau, Wolfgang; Predel, Reinhard; Johnston, Paul R; Ioannidis, Panagiotis; Waterhouse, Robert M; Nauen, Ralf; Schorn, Corinna; Ott, Mark-Christoph; Maiwald, Frank; Johnston, J Spencer; Gondhalekar, Ameya D; Scharf, Michael E; Peterson, Brittany F; Raje, Kapil R; Hottel, Benjamin A; Armisén, David; Crumière, Antonin Jean Johan; Refki, Peter Nagui; Santos, Maria Emilia; Sghaier, Essia; Viala, Sèverine; Khila, Abderrahman; Ahn, Seung-Joon; Childers, Christopher; Lee, Chien-Yueh; Lin, Han; Hughes, Daniel S T; Duncan, Elizabeth J; Murali, Shwetha C; Qu, Jiaxin; Dugan, Shannon; Lee, Sandra L; Chao, Hsu; Dinh, Huyen; Han, Yi; Doddapaneni, Harshavardhan; Worley, Kim C; Muzny, Donna M; Wheeler, David; Panfilio, Kristen A; Vargas Jentzsch, Iris M; Vargo, Edward L; Booth, Warren; Friedrich, Markus; Weirauch, Matthew T; Anderson, Michelle A E; Jones, Jeffery W; Mittapalli, Omprakash; Zhao, Chaoyang; Zhou, Jing-Jiang; Evans, Jay D; Attardo, Geoffrey M; Robertson, Hugh M; Zdobnov, Evgeny M; Ribeiro, Jose M C; Gibbs, Richard A; Werren, John H; Palli, Subba R; Schal, Coby; Richards, Stephen
2016-02-02
The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650 Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host-symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human-bed bug and symbiont-bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasite.
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Unique features of a global human ectoparasite identified through sequencing of the bed bug genome
Benoit, Joshua B.; Adelman, Zach N.; Reinhardt, Klaus; Dolan, Amanda; Poelchau, Monica; Jennings, Emily C.; Szuter, Elise M.; Hagan, Richard W.; Gujar, Hemant; Shukla, Jayendra Nath; Zhu, Fang; Mohan, M.; Nelson, David R.; Rosendale, Andrew J.; Derst, Christian; Resnik, Valentina; Wernig, Sebastian; Menegazzi, Pamela; Wegener, Christian; Peschel, Nicolai; Hendershot, Jacob M.; Blenau, Wolfgang; Predel, Reinhard; Johnston, Paul R.; Ioannidis, Panagiotis; Waterhouse, Robert M.; Nauen, Ralf; Schorn, Corinna; Ott, Mark-Christoph; Maiwald, Frank; Johnston, J. Spencer; Gondhalekar, Ameya D.; Scharf, Michael E.; Peterson, Brittany F.; Raje, Kapil R.; Hottel, Benjamin A.; Armisén, David; Crumière, Antonin Jean Johan; Refki, Peter Nagui; Santos, Maria Emilia; Sghaier, Essia; Viala, Sèverine; Khila, Abderrahman; Ahn, Seung-Joon; Childers, Christopher; Lee, Chien-Yueh; Lin, Han; Hughes, Daniel S. T.; Duncan, Elizabeth J.; Murali, Shwetha C.; Qu, Jiaxin; Dugan, Shannon; Lee, Sandra L.; Chao, Hsu; Dinh, Huyen; Han, Yi; Doddapaneni, Harshavardhan; Worley, Kim C.; Muzny, Donna M.; Wheeler, David; Panfilio, Kristen A.; Vargas Jentzsch, Iris M.; Vargo, Edward L.; Booth, Warren; Friedrich, Markus; Weirauch, Matthew T.; Anderson, Michelle A. E.; Jones, Jeffery W.; Mittapalli, Omprakash; Zhao, Chaoyang; Zhou, Jing-Jiang; Evans, Jay D.; Attardo, Geoffrey M.; Robertson, Hugh M.; Zdobnov, Evgeny M.; Ribeiro, Jose M. C.; Gibbs, Richard A.; Werren, John H.; Palli, Subba R.; Schal, Coby; Richards, Stephen
2016-01-01
The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650 Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host–symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human–bed bug and symbiont–bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasite. PMID:26836814
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Hiddlestone, H J
1974-12-11
At the invitation of the Chinese government a New Zealand delegation visited the People's Republic of China to observe medical administration and public health. The use of "barefoot doctors" and the integration of western and traditional medicine has led to a revision of the organization of medical care. Acupuncture has been implemented for anesthesia, diagnosis, treatment and drug addiction. Herbal medicine, treatment of fractures and burns and cupping and mixibustion are additional methods of treatment employed with success by the Chinese. The emphasis on preventive medicine has led to education of the people and "barefoot doctors" and to the elimination of various pests such as flies, mosquitoes, rats, bedbugs the semination of a wide range of endemic bacterial and viral diseases such as plague, cholera and leprosy and the elimination of diseases such as malaria, hookworm and venereal diseases. Population control is emphasized in schools (premarital sex is strongly disapproved of) and through the revolutionary philosophy that women can only gain equality when they are freed from endless childbearing. Birth rates have been reduced to 6.5 per 1000 in urban Shanghai. Medical training has been shortened to 3 1/2 years and is taught with the philosophy that it will be used to serve the people.
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Effectiveness of a Reduced-Risk Insecticide Based Bed Bug Management Program in Low-Income Housing.
Singh, Narinderpal; Wang, Changlu; Cooper, Richard
2013-11-28
Bed bug (Cimex lectularius L.) infestations are becoming increasingly common in low-income communities. Once they are introduced, elimination is very difficult. As part of the efforts to develop effective and safe bed bug management programs, we conducted a laboratory study evaluating the efficacy of a reduced-risk insecticide-Alpine aerosol (0.5% dinotefuran). We then conducted a field evaluation of a reduced-risk insecticide based integrated pest management (IPM) program in low-income family apartments with young children. In laboratory evaluations, direct spray and 5 min exposure to dry Alpine aerosol residue caused 100.0 ± 0.0 and 91.7 ± 8.3% mortality to bed bug nymphs, respectively. Direct Alpine aerosol spray killed 91.3 ± 4.3% of the eggs. The IPM program included education, steam, bagging infested linens, placing intercepting devices under furniture legs and corners of rooms, applying Alpine aerosol and Alpine dust (0.25% dinotefuran, 95% diatomaceous earth dust), and regularly scheduled monitoring and re-treatment. Nine apartments ranging from 1-1,428 (median: 29) bed bugs based on visual inspection and Climbup interceptor counts were included. Over a 6-month period, an average 172 g insecticide (Alpine aerosol + Alpine dust) was used in each apartment, a 96% reduction in pesticide usage compared to chemical only treatment reported in a similar environment. The IPM program resulted in an average of 96.8 ± 2.2% reduction in the number of bed bugs. However, elimination of bed bugs was only achieved in three lightly infested apartments (<30 bed bugs at the beginning). Elimination success was closely correlated with the level of bed bug populations.
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Matos, Yvonne K; Osborne, Jason A; Schal, Coby
2017-11-07
Bed bugs (Cimex lectularius L.) are now endemic in most major cities, but information regarding their basic biology is still largely based on research done over four decades ago. We investigated the effects of starvation, mating, sperm storage, and female and male age on egg production and hatch. Egg production cycles varied with the number of bloodmeals that females received. Once-mated females fed every 5 d had constant egg production for ∼75 d followed by a monotonic decline to near zero. Percentage egg hatch was high and constant, but declined after ∼30 d to near zero. To determine whether the age of the female, male, or sperm affected these patterns, we mated newly eclosed females to 60-d-old virgin males, 60-d-old mated males, or newly eclosed males. Females produced the most eggs when mated to young males, followed by old mated males, and then old virgin males; percentage hatch followed a similar pattern, suggesting that sperm stored within males for long was deficient. To examine effects of sperm stored within females, we mated newly eclosed females, starved them for 30 or 60 d, then fed them every 5 d. The 60-d starved group produced fewer eggs than the 30-d starved group, and both produced fewer eggs than young females mated to old or young males. Longer periods of sperm storage within females caused lower corresponding percentage hatch. These findings indicate egg production and hatch are governed by complex interactions among female and male age, frequency of feeding and mating, and sperm condition. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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Effectiveness of a Reduced-Risk Insecticide Based Bed Bug Management Program in Low-Income Housing
Singh, Narinderpal; Wang, Changlu; Cooper, Richard
2013-01-01
Bed bug (Cimex lectularius L.) infestations are becoming increasingly common in low-income communities. Once they are introduced, elimination is very difficult. As part of the efforts to develop effective and safe bed bug management programs, we conducted a laboratory study evaluating the efficacy of a reduced-risk insecticide—Alpine aerosol (0.5% dinotefuran). We then conducted a field evaluation of a reduced-risk insecticide based integrated pest management (IPM) program in low-income family apartments with young children. In laboratory evaluations, direct spray and 5 min exposure to dry Alpine aerosol residue caused 100.0 ± 0.0 and 91.7 ± 8.3% mortality to bed bug nymphs, respectively. Direct Alpine aerosol spray killed 91.3 ± 4.3% of the eggs. The IPM program included education, steam, bagging infested linens, placing intercepting devices under furniture legs and corners of rooms, applying Alpine aerosol and Alpine dust (0.25% dinotefuran, 95% diatomaceous earth dust), and regularly scheduled monitoring and re-treatment. Nine apartments ranging from 1–1,428 (median: 29) bed bugs based on visual inspection and Climbup interceptor counts were included. Over a 6-month period, an average 172 g insecticide (Alpine aerosol + Alpine dust) was used in each apartment, a 96% reduction in pesticide usage compared to chemical only treatment reported in a similar environment. The IPM program resulted in an average of 96.8 ± 2.2% reduction in the number of bed bugs. However, elimination of bed bugs was only achieved in three lightly infested apartments (<30 bed bugs at the beginning). Elimination success was closely correlated with the level of bed bug populations. PMID:26462533
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Matos, Yvonne K; Sierras, Angela; Schal, Coby
2017-06-01
Baits are a preferred method of urban pest management. Baits enable more targeted insecticide applications with a fraction of the active ingredient used in residual sprays. Bait translocation by foragers, and consequent secondary kill of nonforagers, enhances bait effectiveness in social insects, and in other group-living species like German cockroaches (Blattella germanica L.). We investigated the potential for secondary kill in bed bugs (Cimex lectularius L.), another gregarious species, using a liquid bait. We first investigated whether blood-fed adults enhance nymph survivorship within aggregations by increasing the local relative humidity (RH) and providing fecal nutrients. Higher RH (50% and 95%) resulted in greater survivorship of first instars compared with 0% RH. Therefore, in subsequent experiments, we controlled RH to decouple its effect on nymph survivorship from effects of fecal nutrients. The presence of fed or unfed adults did not increase unfed first instar survivorship, suggesting that if nymphs ingested feces, its nutritional benefits were minimal. Nymph survivorship was unaffected by the presence of adult males fed fipronil or clothianidin, suggesting that unlike in cockroaches, highly effective insecticides might not be effective as secondary kill toxicants in bed bugs. To directly compare secondary kill in first-instar bed bugs and B. germanica, we exposed both to insecticide-laden adult B. germanica feces. Whereas first-instar B. germanica died in the presence of insecticide-laden feces, bed bugs did not. We, therefore, conclude that secondary kill with neuroactive insecticides will likely not be a significant factor in bed bug population suppression. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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Wu, Yage; Tracy, Dylan M; Barbarin, Alexis M; Barbu, Corentin M; Levy, Michael Z
2014-07-01
We conducted a door-to-door survey in a residential census tract of Philadelphia to estimate the prevalence and spatial patterns of recent bed bug infestations. We interviewed 596 residents, of whom 66 (11.1%) reported recent bed bug infestations. We confirmed current infestations in a subset of 15 (68.2%) of 22 inspected households. Most residents reported that their infestation began within the past year (2012-2013). We found no correlation between property value and infestation status. Spatial analyses showed significant clustering of bed bug infestations only at fine scales, suggesting limited active dispersal of the insects. Residents used a large variety of treatment methods to eliminate bed bugs, but only 48.1% reported success. Our results provide a prevalence estimate of recent bed bug infestations and highlight the importance of passive rather than active dispersal of bed bugs even among dense urban row homes. © The American Society of Tropical Medicine and Hygiene.
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Psychological effects of bed bug attacks (Cimex lectularius L.).
Goddard, Jerome; de Shazo, Richard
2012-01-01
In some individuals, psychological sequelae resulting from bed bug biting events include nightmares, flashbacks, hypervigilance (to keep the bugs away), insomnia, anxiety, avoidance behaviors, and personal dysfunction. These symptoms are suggestive of posttraumatic stress disorder (PTSD). We used a previously published PTSD checklist to analyze online blogs and other Internet sites where bed bug postings occur to assess postings for evidence of emotional trauma. One hundred thirty-five postings were read and analyzed, and 110 (81%) of those postings reported psychological effects from bed bug infestations. Scoring with the PTSD checklist revealed a range of 0-52 (mean 13.25; SD 9.38); one met the criteria (≥50) considered positive for PTSD. Based upon our survey of online postings concerning such effects, an as-yet-to-be-determined proportion of individuals who experience bed bug bites develop moderate-to-severe negative emotional symptoms after infestations. These individuals should be identified in the course of their interactions with health professionals so that appropriate mental health care may be provided. Copyright © 2012. Published by Elsevier Inc.
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Hinson, K R; Benson, E P; Zungoli, P A; Bridges, W C; Ellis, B R
2016-12-01
Few studies have addressed the efficacy of insecticides used against eggs and first-instar nymphs of the bed bug, Cimex lectularius L. (Hemiptera: Cimicidae). Insect eggs are often resistant to insecticides; therefore, information on which products are effective is important. We evaluated the efficacy of four commonly used insecticide sprays applied directly to bed bug eggs. We also evaluated the efficacy of these insecticides to first-instar nymphs exposed to residuals resulting from directly spraying eggs. Temprid SC (beta-cyfluthrin, imidacloprid) was the most effective insecticide at preventing egg hatch (13% hatch rate) for pyrethroid-resistant, field-strain (Jersey City) bed bugs compared with a control (water [99% hatch rate]), Bedlam (MGK-264, sumithrin [84% hatch rate]), Demand CS (lambda-cyhalothrin [91% hatch rate]), and Phantom SC (chlorfenapyr [95% hatch rate]). Demand CS and Temprid SC were most effective at preventing egg hatch (0%) for an insecticide-susceptible (Harold Harlan) strain, followed by Bedlam (28%). Phantom SC produced a hatch rate similar to the control (97% and 96%, respectively). Harold Harlan-strain nymphs showed 100% survival for the control but 0% survival for Bedlam and Phantom SC. Jersey City-strain nymphs showed 100% survival for the control, 99% survival for Bedlam, 0% survival for Demand CS, 4% survival for Phantom SC, and 38% survival for Temprid SC. Demand CS was less effective at preventing hatch (91% hatch rate) of Jersey City-strain nymphs but was the only product to kill all nymphs (0% survival). One of the least effective products for preventing Jersey City-strain egg hatch (Phantom SC, 95% hatch rate) was the second most effective at killing nymphs, leaving only six of 141 alive. These findings indicate that survival of directly sprayed eggs and residually exposed, first-instar nymphs varies by strain, life stage, and product used. © The Authors 2016. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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2016-01-01
Jakubowski, T.L., Perron, T.J., and Teixeira, E. (2015). Rashes in school: Can they stay, or should they go? NASN School Nurse, 30(5): 274-282. (Original DOI: 10.1177/1942602X15596815)In the September 2015 issue of NASN School Nurse, the images for Lyme Disease and Spider bites were reversed. The correct order appears below.spnas;31/1/61/TABLE11942602X15621761T1table1-1942602X15621761Table 5.Bites/Stings in ChildrenDiagnosis(Bites, Stings, cutaneous infestations)Rash DescriptionSigns and SymptomsStay in School or Go Home?PhotoLyme Disease (Borrelia burgdorferi)Transmitted by deer tickErythema rash when present, "Bull's eye rash" distinct red borders with central clearing.Rash at site of bite but can have multiple rashesFever, joint pain, malaise, headache, single swollen joint usually knee usually accompany the rash.Not Contagious: Can stay at school.Incubation: 1-32 days median is 11 days. April through October with more than 50% of the cases presenting in June and July.Rocky Mountain Spotted Fever (RMSF) Rickettial infection transmitted by wood ticks.Characteristic spotted rash, maculopapular and sometimes petechial rash.Triad of fever, rash, and history of tick exposure, headache, vomiting, sore throatNot Contagious: Can stay at school.Rash initially appears on wrists and ankles and spreads to trunk within hours. Palms of hands and soles of feet are also involved.Incubation: Average time frame one week. Can range 2-14 days. August through September highest prevalence.Scabies(Mites)Papules and burrows, excoriation secondary to scratching.Intense itching especially at night. Commonly seen between the fingers and toes.Is Contagious: Should go home.Skin-to-skin contact. Mites can remain alive for > 2 days on clothing and bedding.Incubation: 4-6 weeksIf the child had it previously 1-4 days.*Can return to school with medical clearance.Bee stingsLocalized swelling, redness. If allergic can spread rapidly. Raised pink wheel.Pain, redness, swelling, hives if allergic, respiratory distress if highly allergic.Not Contagious: Can stay at school.Spider bitesLocalized redness, swelling, can spread if infection - cellulitis can occur.Pain, redness, swelling. Bites are commonly seen on thighs, buttocks and abdomen.Not Contagious: Can stay at school.Bed Bugs(Cimex Lectularius)Red itchy welts that appear in a row. Numerous bites appear as a red itchy wide spread rash. Often mistaken for mosquito bites.Red, itchy, swellingAppear on face neck and extremities, areas exposed during sleep.Not Contagious: Can stay at school.Incubation: Bites may not appear for several days after exposure.Flea BitesRed spots surrounded by reddened haloes.Red, itchy.Commonly seen on the feet and ankles.Not Contagious: Can stay at school. © 2015 The Author(s).
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Behavioral Responses of the Bed Bug to Permethrin-Impregnated ActiveGuard™ Fabric.
Jones, Susan C; Bryant, Joshua L; Harrison, Scott A
2013-06-07
ActiveGuard™ Mattress Liners have been used to control house dust mites, and they also are commercially available as an integrated pest management tool for use against bed bugs (Cimex lectularius). The aim of our study was to evaluate responses of numerous populations of the bed bug to the permethrin-impregnated fabric, with particular regard to contact toxicity, repellency, and feeding inhibition. Continuous exposure to ActiveGuard fabric resulted in rapid intoxication for three of four populations, with 87 to 100% of moderately pyrethroid-resistant and susceptible bed bugs succumbing by 1 d. In comparison, a highly resistant population reached 22% mortality at 10 d. Video data revealed that bed bugs readily traversed ActiveGuard fabric and spent a considerable amount of time moving about and resting on it during a 12-h period. ActiveGuard fabric was non-repellent to bed bugs from five tested populations. Furthermore, significantly fewer bed bugs successfully fed to repletion through ActiveGuard fabric than through blank fabric for the five populations. With just 30 min of feeding exposure, mortality ranged from 4% to 83%, depending upon the bed bug strain. These laboratory studies indicate that ActiveGuard liners adversely affected bed bugs from diverse populations.
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Testing a Threshold-Based Bed Bug Management Approach in Apartment Buildings.
Singh, Narinderpal; Wang, Changlu; Zha, Chen; Cooper, Richard; Robson, Mark
2017-07-26
We tested a threshold-based bed bug ( Cimex lectularius L.) management approach with the goal of achieving elimination with minimal or no insecticide application. Thirty-two bed bug infested apartments were identified. These apartments were divided into four treatment groups based on apartment size and initial bed bug count, obtained through a combination of visual inspection and bed bug monitors: I- Non-chemical only in apartments with 1-12 bed bug count, II- Chemical control only in apartments with 1-12 bed bug count, III- Non-chemical and chemical control in apartments with >12 bed bug count, and IV- Chemical control only in apartments with ≥11 bed bug count. All apartments were monitored or treated once every two weeks for a maximum of 28 wk. Treatment I eliminated bed bugs in a similar amount of time to treatment II. Time to eliminate bed bugs was similar between treatment III and IV but required significantly less insecticide spray in treatment III than that in treatment IV. A threshold-based management approach (non-chemical only or non-chemical and chemical) can eliminate bed bugs in a similar amount of time, using little to no pesticide compared to a chemical only approach.
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Blood constituents as phagostimulants for the bed bug Cimex lectularius L.
Romero, Alvaro; Schal, Coby
2014-02-15
Many hematophagous arthropods are stimulated by blood constituents to initiate feeding. We used a membrane-based feeding system to identify chemicals that stimulate acceptance and engorgement responses in various life stages of bed bugs. Water was fortified with a variety of compounds (e.g. salts, amino acids, vitamins, nucleotides, cholesterol and fatty acids) in these bioassays. ATP was the most effective phagostimulant in adults and nymphs, resulting in >70% of bed bugs fully engorging. Addition of NaCl to low ATP solutions that alone elicited <50% engorgement significantly enhanced feeding responses of bed bugs. A comparison of feeding responses with solutions of various adenine nucleotides showed that ATP was more stimulatory than ADP, which was more effective than AMP. Feeding assays with physiological levels of other blood constituents such as d-glucose, albumin, globulin, cholesterol and mixtures of vitamins and amino acids did not stimulate engorgement, suggesting that adenine nucleotides are the most important feeding stimulants in bed bugs. Identification of phagostimulants for bed bugs will contribute towards the development of artificial diets for rearing purposes, as well as for the development of alternative methods to eliminate bed bug infestations.
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Testing a Threshold-Based Bed Bug Management Approach in Apartment Buildings
Singh, Narinderpal; Zha, Chen; Cooper, Richard; Robson, Mark
2017-01-01
We tested a threshold-based bed bug (Cimex lectularius L.) management approach with the goal of achieving elimination with minimal or no insecticide application. Thirty-two bed bug infested apartments were identified. These apartments were divided into four treatment groups based on apartment size and initial bed bug count, obtained through a combination of visual inspection and bed bug monitors: I- Non-chemical only in apartments with 1–12 bed bug count, II- Chemical control only in apartments with 1–12 bed bug count, III- Non-chemical and chemical control in apartments with >12 bed bug count, and IV- Chemical control only in apartments with ≥11 bed bug count. All apartments were monitored or treated once every two weeks for a maximum of 28 wk. Treatment I eliminated bed bugs in a similar amount of time to treatment II. Time to eliminate bed bugs was similar between treatment III and IV but required significantly less insecticide spray in treatment III than that in treatment IV. A threshold-based management approach (non-chemical only or non-chemical and chemical) can eliminate bed bugs in a similar amount of time, using little to no pesticide compared to a chemical only approach. PMID:28933720
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Booth, Warren; Saenz, Virna L; Santangelo, Richard G; Wang, Changlu; Schal, Coby; Vargo, Edward L
2012-05-01
The bed bug, Cimex lectularius L. (Hemiptera: Cimicidae), has experienced an extraordinary global resurgence in recent years, the reasons for which remain poorly understood. Once considered a pest of lower socioeconomic classes, bed bugs are now found extensively across all residential settings, with widespread infestations established in multiapartment buildings. Within such buildings, understanding the population genetic structure and patterns of dispersal may prove critical to the development of effective control strategies. Here, we describe the development of 24 high-resolution microsatellite markers through next generation 454 pyrosequencing and their application to elucidate infestation dynamics within three multistory apartment buildings in the United States. Results reveal contrasting characteristics potentially representative of geographic or locale differences. In Raleigh, NC, an infestation within an apartment building seemed to have started from a single introduction followed by extensive spread. In Jersey City, NJ, two or more introductions followed by spread are evident in two buildings. Populations within single apartments in all buildings were characterized by high levels of relatedness and low levels of diversity, indicative of foundation from small, genetically depauperate propagules. Regardless of the number of unique introductions, genetic data indicate that spread within buildings is extensive, supporting both active and human-mediated dispersal within and between adjacent rooms or apartments spanning multiple floors.
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Balvín, Ondrej; Booth, Warren
2018-03-15
For over two decades, the bed bug, Cimex lectularius L. (Hemiptera: Cimicidae) has been undergoing a dramatic global resurgence, likely in part to the evolution of mechanisms conferring resistance to insecticides. One such mechanism is knock-down resistance (kdr), resulting from nonsynonymous mutations within the voltage-gated sodium channel (VGSC) gene. To date, three mutations have been identified in C. lectularius, V419L, L925I, and I936F. Using Sanger sequencing, the frequency and distribution of these VGSC mutations across 131 populations collected from the bat-associated and human-associated lineages of C. lectularius found in Europe are documented. All populations from the bat-associated lineage lacked mutations at the three sites. In contrast, the majority of populations associated with humans (93.5%) possessed the mutation at the L925I site. The I936F mutation, previously only reported in Israel and Australia, was found in nine populations spread across several European countries, including the Czech Republic and Switzerland. The high frequency of kdr-associated resistance already reported in C. lectularius and the occurrence and broad geographic distribution of this additional VGSC mutation, questions the continued use of pyrethroids in the treatment of infestations.
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Susser, Stephanie Rebecca; Perron, Stéphane; Fournier, Michel; Jacques, Louis; Denis, Geoffroy; Tessier, François; Roberge, Pasquale
2012-01-01
To assess whether bed bug infestation was linked to sleep disturbances and symptoms of anxiety and depression. Exploratory cross-sectional study. Convenience sample of tenants recruited in apartment complexes from Montreal, Canada. 39 bed bug-exposed tenants were compared with 52 unexposed tenants. The effect of bed bug-exposed tenants on sleep disturbances, anxiety and depression symptoms measured using the Pittsburgh Sleep Quality Index, 5th subscale, Generalised Anxiety Disorder 7-item scale and Patient Health Questionnaire, 9-item, respectively. In adjusted models, bed bug infestation was strongly associated with measured anxiety symptoms (OR (95% CI)=4.8 (1.5 to 14.7)) and sleep disturbance (OR (95% CI)=5.0 (1.3-18.8)). There was a trend to report more symptoms of depression in the bed bug-infested group, although this finding was not statistically significant ((OR (95% CI)=2.5(0.8 to 7.3)). These results suggest that individuals exposed to bed bug infestations are at risk of experiencing sleep disturbance and of developing symptoms of anxiety and possibly depression. Greater clinical awareness of this problem is needed in order for patients to receive appropriate mental healthcare. These findings highlight the need for undertaking of deeper inquiry, as well as greater collaboration between medical professionals, public health and community stakeholders.
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Evaluation of a model community-wide bed bug management program in affordable housing.
Cooper, Richard A; Wang, Changlu; Singh, Narinderpal
2016-01-01
Low-income apartment communities in the United States are suffering from disproportionally high bed bug, Cimex lectularius L., infestations owing to lack of effective monitoring and treatment. Studies examining the effectiveness of integrated pest management (IPM) for the control of bed bugs in affordable housing have been limited to small subsets of bed-bug-infested apartments, rather than at the apartment community level. We developed, implemented and evaluated a complex-wide IPM program for bed bugs in an affordable housing community. Proactive inspections and biweekly treatments using a combination of non-chemical and chemical methods until bed bugs were not detected for three biweekly monitoring visits were key elements of the IPM program. A total of 55 bed-bug-infested apartments were identified during the initial inspection. Property management was unaware of 71% of these infestations. Over the next 12 months, 14 additional infested apartments were identified. The IPM program resulted in a 98% reduction in bed bug counts among treated apartments and reduced infestation rates from 15 to 2.2% after 12 months. Adopting a complex-wide bed bug IPM program, incorporating proactive monitoring, and biweekly treatments of infested apartments utilizing non-chemical and chemical methods can successfully reduce infestation rates to very low levels. © 2015 Society of Chemical Industry.
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Behavioral Responses of the Bed Bug to Permethrin-Impregnated ActiveGuard™ Fabric
Jones, Susan C.; Bryant, Joshua L.; Harrison, Scott A.
2013-01-01
ActiveGuard™ Mattress Liners have been used to control house dust mites, and they also are commercially available as an integrated pest management tool for use against bed bugs (Cimex lectularius). The aim of our study was to evaluate responses of numerous populations of the bed bug to the permethrin-impregnated fabric, with particular regard to contact toxicity, repellency, and feeding inhibition. Continuous exposure to ActiveGuard fabric resulted in rapid intoxication for three of four populations, with 87 to 100% of moderately pyrethroid-resistant and susceptible bed bugs succumbing by 1 d. In comparison, a highly resistant population reached 22% mortality at 10 d. Video data revealed that bed bugs readily traversed ActiveGuard fabric and spent a considerable amount of time moving about and resting on it during a 12-h period. ActiveGuard fabric was non-repellent to bed bugs from five tested populations. Furthermore, significantly fewer bed bugs successfully fed to repletion through ActiveGuard fabric than through blank fabric for the five populations. With just 30 min of feeding exposure, mortality ranged from 4% to 83%, depending upon the bed bug strain. These laboratory studies indicate that ActiveGuard liners adversely affected bed bugs from diverse populations. PMID:26464388
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Pearce, R.D.; O'Shea, T.J.; Shankar, V.; Rupprecht, C.E.
2007-01-01
Recently, bat ectoparasites have been demonstrated to harbor pathogens of potential importance to humans. We evaluated antirabies antibody seroprevalence and the presence of ectoparasites in big brown bats (Eptesicus fuscus) sampled in 2002 and 2003 in Colorado to investigate if an association existed between ectoparasite intensity and exposure to rabies virus (RV). We used logistic regression and Akaike's Information Criteria adjusted for sample size (AICc) in a post-hoc analysis to investigate the relative importance of three ectoparasite species, as well as bat colony size, year sampled, age class, colony size, and year interaction on the presence of rabies virus neutralizing antibodies (VNA) in serum of wild E. fuscus. We obtained serum samples and ectoparasite counts from big brown bats simultaneously in 2002 and 2003. Although the presence of ectoparasites (Steatonyssus occidentalis and Spinturnix bakeri) were important in elucidating VNA seroprevalence, their intensities were higher in seronegative bats than in seropositive bats, and the presence of a third ectoparasite (Cimex pilosellus) was inconsequential. Colony size and year sampled were the most important variables in these AICc models. These findings suggest that these ectoparasites do not enhance exposure of big brown bats to RV. ?? 2007 Mary Ann Liebert, Inc.
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Olson, Joelle F; Vers, Leonard M Ver; Moon, Roger D; Kells, Stephen A
2017-01-01
After feeding, bed bugs aggregate in cracks and crevices near a host. Aggregation and arrestment are mediated by tactile and chemical stimuli associated with the bugs' feces and exuviae. Volatiles derived from fecally stained filter papers were analyzed by solid-phase microextraction (SPME) and evaluated using a multichoice behavioral assay to determine their impact on bed bug aggregation. In addition, crude fecal extracts were collected in methanol, analyzed by gas chromatography coupled with electroantennogram detection (GC-EAD) and mass spectrometry (GC-MS) and evaluated in open-air multichoice behavioral assays. The SPME method was used to detect (E)-2-hexenal and (E)-2-octenal in heated bed bug feces. The presence of these two volatile components did not affect aggregation. Analysis of the crude fecal extracts revealed several semi-volatile nitrogenous compounds, a carboxylic acid and a sulfur-based compound. Adult antennae responded to compounds eluted from three regions of the crude extract using GC-EAD. A combination of two compounds, dimethyl trisulfide and methyldiethanolamine, resulted in aggregation responses equivalent to the original crude extract. Bed bug aggregation is mediated by semi-volatile compounds derived from fecal extracts, and two compounds are sufficient to elicit aggregation. The two compounds identified here could be used to enhance the effectiveness of insecticidal applications or improve monitoring techniques. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry.
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Pereira, R M; Taylor, A S; Lehnert, M P; Koehler, P G
2013-06-01
Effects of host availability and feeding period on bed bugs, Cimex lectularius (L.) (Hemiptera: Cimicidae), were measured. Population growth and the potential harmful effect of bed bug populations on human hosts were modelled. Bloodmeal sizes were affected by both feeding length and frequency, with >2-fold difference between insects fed daily or weekly. Blood consumption increased >2-fold between bed bugs fed occasionally and often, and 1.5-fold between occasional and daily feeding. Bed bugs fed more often than once a week, potentially every 2-4 days. Egg production was associated with nutrition, being strongly correlated with blood consumption in the previous week. Bed bug populations can grow under different feeding regimes and are hard to control with <80% mortality. Bed bugs can survive and grow even in locations with a limited blood supply, where bed bug persistence may be important for the continual spread of populations. Persistence in non-traditional locations and a potential association with human pathogens increase the health risks of bed bugs. Potential blood loss as a result of a bed bug can have serious consequences because uncontrolled populations can reach harmful levels in 3-8 months. The reproduction potential of bed bug populations suggests serious consequences to human health and the need for efficacious control measures. © 2012 The Royal Entomological Society.
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Wang, Lei; Cai, Xuquan; Xu, Yijuan
2015-01-01
The recent resurgence of bed bugs (Cimex spp.) in many developed countries has drawn increasing attention worldwide. The status of urban bed bug infestations were investigated in Shenzhen and Dongguan, two major cities in southern Guangdong Province of southern China, based on pest control service records from two different companies (one during 2012 and another during 2013). The results showed that Shenzhen and Dongguan have a severe problem with bed bug infestations: the control of bed bugs is a constant concern, except during the winter. In Shenzhen, a similar number of premises were treated for bed bugs in central business districts and suburban districts. However, in Dongguan, more premises were treated for bed bugs in suburban districts than in central business districts. The treatment rate for worker sleeping quarters, apartments, hotel, and private houses in Shenzhen was 53.8, 43.0, 1.9, and 1.3%, respectively. The percentage of treated rooms was 56.1% for worker sleeping quarters and 91.1% for apartments. In Dongguan, the treatment rate for worker sleeping quarters, apartments, hotel, and private houses was 90.0, 10.0, 0.0, and 0.0%, respectively. © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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Polsinelli, Gregory A; Singh, Sanjay K; Mishra, Rajesh K; Suranyi, Robert; Ragsdale, David W; Pang, Yuan-Ping; Brimijoin, Stephen
2010-09-06
Insecticides directed against acetylcholinesterase (AChE) are facing increased resistance among target species as well as increasing concerns for human toxicity. The result has been a resurgence of disease vectors, insects destructive to agriculture, and residential pests. We previously reported a free cysteine (Cys) residue at the entrance to the AChE active site in some insects but not higher vertebrates. We also reported Cys-targeting methanethiosulfonate molecules (AMTSn), which, under conditions that spared human AChE, caused total irreversible inhibition of aphid AChE, 95% inhibition of AChE from the malaria vector mosquito (Anopheles gambia), and >80% inhibition of activity from the yellow fever mosquito (Aedes aegypti) and northern house mosquito (Culex pipiens). We now find the same compounds inhibit AChE from cockroaches (Blattella germanica and Periplaneta americana), the flour beetle (Tribolium confusum), the multi-colored Asian ladybird beetle (Harmonia axyridis), the bed bug (Cimex lectularius), and a wasp (Vespula maculifrons), with IC(50) values of approximately 1-11muM. Our results support further study of Cys-targeting inhibitors as conceptually novel insecticides that may be free of resistance in a range of insect pests and disease vectors and, compared with current compounds, should demonstrate much lower toxicity to mammals, birds, and fish. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
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Lazarus, L; Chettiar, J; Deering, K; Nabess, R; Shannon, K
2011-01-01
This study explored low-income and transitional housing environments of women sex workers and their role in shaping agency and power in negotiating safety and sexual risk reduction in Vancouver, Canada. A series of 12 focus group discussions were conducted with 73 women currently involved in street-based sex work. These women were purposively sampled for a range of experiences living in low-income housing environments, including homeless shelters, transitional housing, and co-ed and women-only single room occupancy (SRO) hotels. Drawing on the risk environment framework and theoretical constructs of gender, agency and power, analyses demonstrate that women continue to be vulnerable to violence and sexual and economic exploitation and have reduced ability to negotiate risk reduction resulting from the physical, structural and social environments of current dominant male-centred housing models. Within the physical environment, women described inhabitable housing conditions in SROs with infestations of bedbugs and rats, leading women to even more transitional housing options such as shelters and couch-surfing. In many cases, this resulted in their economic exploitation and increased sexual risk. Within the structural environment, enforcement of curfews and guest policies forced women to accept risky clients to meet curfew, or work outdoors where their ability to negotiate safety and condom use were limited. Certain policies promoted women’s agency and mitigated their ability to reduce risks when selling sex. These included flexible curfews and being able to bring clients home. The social environments of co-ed single-room occupancy hotels resulted in repeated violence by male residents and discrimination by male building staff. Women-only shelters and SROs facilitated ‘enabling environments’ where women developed support systems with other working women that resulted in safer work practices. The narratives expressed in this study reveal the critical need for public health interventions and safer supportive housing to account for the daily lived experiences of women sex workers. PMID:22018526
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Daruwalla, Nayreen; Hate, Ketaki; Pinto, Preethi; Ambavkar, Gauri; Kakad, Bhaskar; Osrin, David
2017-01-01
Background: The contribution of structural inequalities and societal legitimisation to violence against women, which 30% of women in India survive each year, is widely accepted. There is a consensus that interventions should aim to change gender norms, particularly through community mobilisation. How this should be done is less clear. Methods: We did a qualitative study in a large informal settlement in Mumbai, an environment that characterises 41% of households. After reviewing the anonymised records of consultations with 1653 survivors of violence, we conducted 5 focus group discussions and 13 individual interviews with 71 women and men representing a range of age groups and communities. We based the interviews on fictitious biographical vignettes to elicit responses and develop an understanding of social norms. We wondered whether, in trying to change norms, we might exploit the disjunction between descriptive norms (beliefs about what others actually do) and injunctive norms (beliefs about what others think one ought to do), focusing program activities on evidence that descriptive norms are changing. Results: We found that descriptive and injunctive norms were relatively similar with regard to femininity, masculinity, the need for marriage and childbearing, resistance to separation and divorce, and disapproval of friendships between women and men. Some constraints on women’s dress and mobility were relaxing, but there were more substantial differences between descriptive and injunctive norms around women’s education, control of income and finances, and premarital sexual relationships. Conclusions: Programmatically, we hope to exploit these areas of mismatch in the context of injunctive norms generally inimical to violence against women. We propose that an under-appreciated strategy is expansion of the reference group: induction of relatively isolated women and men into broader social groups whose descriptive and injunctive norms do not tolerate violence PMID:29164180
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Lazarus, L; Chettiar, J; Deering, K; Nabess, R; Shannon, K
2011-12-01
This study explored low-income and transitional housing environments of women sex workers and their role in shaping agency and power in negotiating safety and sexual risk reduction in Vancouver, Canada. A series of 12 focus group discussions were conducted with 73 women currently involved in street-based sex work. These women were purposively sampled for a range of experiences living in low-income housing environments, including homeless shelters, transitional housing, and co-ed and women-only single-room occupancy (SRO) hotels. Drawing on the risk environment framework and theoretical constructs of gender, agency and power, analyses demonstrate that women continue to be vulnerable to violence and sexual and economic exploitation and have reduced ability to negotiate risk reduction resulting from the physical, structural and social environments of current dominant male-centred housing models. Within the physical environment, women described inhabitable housing conditions in SROs with infestations of bedbugs and rats, leading women to even more transitional housing options such as shelters and couch-surfing. In many cases, this resulted in their economic exploitation and increased sexual risk. Within the structural environment, enforcement of curfews and guest policies forced women to accept risky clients to meet curfew, or work outdoors where their ability to negotiate safety and condom use were limited. Certain policies promoted women's agency and mitigated their ability to reduce risks when selling sex. These included flexible curfews and being able to bring clients home. The social environments of co-ed single-room occupancy hotels resulted in repeated violence by male residents and discrimination by male building staff. Women-only shelters and SROs facilitated 'enabling environments' where women developed support systems with other working women that resulted in safer work practices. The narratives expressed in this study reveal the critical need for public health interventions and safer supportive housing to account for the daily lived experiences of women sex workers. Copyright © 2011 Elsevier Ltd. All rights reserved.
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Daruwalla, Nayreen; Hate, Ketaki; Pinto, Preethi; Ambavkar, Gauri; Kakad, Bhaskar; Osrin, David
2017-01-01
Background : The contribution of structural inequalities and societal legitimisation to violence against women, which 30% of women in India survive each year, is widely accepted. There is a consensus that interventions should aim to change gender norms, particularly through community mobilisation. How this should be done is less clear. Methods : We did a qualitative study in a large informal settlement in Mumbai, an environment that characterises 41% of households. After reviewing the anonymised records of consultations with 1653 survivors of violence, we conducted 5 focus group discussions and 13 individual interviews with 71 women and men representing a range of age groups and communities. We based the interviews on fictitious biographical vignettes to elicit responses and develop an understanding of social norms. We wondered whether, in trying to change norms, we might exploit the disjunction between descriptive norms (beliefs about what others actually do) and injunctive norms (beliefs about what others think one ought to do), focusing program activities on evidence that descriptive norms are changing. Results : We found that descriptive and injunctive norms were relatively similar with regard to femininity, masculinity, the need for marriage and childbearing, resistance to separation and divorce, and disapproval of friendships between women and men. Some constraints on women's dress and mobility were relaxing, but there were more substantial differences between descriptive and injunctive norms around women's education, control of income and finances, and premarital sexual relationships. Conclusions : Programmatically, we hope to exploit these areas of mismatch in the context of injunctive norms generally inimical to violence against women. We propose that an under-appreciated strategy is expansion of the reference group: induction of relatively isolated women and men into broader social groups whose descriptive and injunctive norms do not tolerate violence.
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Potential of Essential Oil-Based Pesticides and Detergents for Bed Bug Control.
Singh, Narinderpal; Wang, Changlu; Cooper, Richard
2014-12-01
The bed bug, (Cimex lectularius L.), is a difficult pest to control. Prevalence of insecticide resistance among bed bug populations and concerns over human-insecticide exposure has stimulated the development of alternative bed bug control materials. Many essential oil-based pesticides and detergent insecticides targeting bed bugs have been developed in recent years. We evaluated the efficacy of nine essential oil-based products and two detergents using direct spray and residual contact bioassays in the laboratory. Two conventional insecticides, Temprid SC (imidacloprid and β-cyfluthrin) and Demand CS (λ-cyhalothrin), were used for comparison. Among the 11 nonsynthetic insecticides tested, only EcoRaider (1% geraniol, 1% cedar extract, and 2% sodium lauryl sulfate) and Bed Bug Patrol (0.003% clove oil, 1% peppermint oil, and 1.3% sodium lauryl sulfate) caused >90% mortality of nymphs in direct spray and forced exposure residual assays. However, the efficacy of EcoRaider and Bed Bug Patrol was significantly lower than that of Temprid SC and Demand CS in choice exposure residual bioassay. Direct spray of EcoRaider caused 87% egg mortality, whereas the other nonsynthetic insecticides had little effect on bed bug eggs. EcoRaider and Bed Bug Patrol did not exhibit detectable repellency against bed bugs in the presence of a carbon dioxide source. These findings suggest that EcoRaider and Bed Bug Patrol are potentially useful pesticides for controlling bed bug infestations, but further testing in naturally infested environments is needed. © 2014 Entomological Society of America.
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Ability of bed bug-detecting canines to locate live bed bugs and viable bed bug eggs.
Pfiester, Margie; Koehler, Philip G; Pereira, Roberto M
2008-08-01
The bed bug, Cimex lectularius L., like other bed bug species, is difficult to visually locate because it is cryptic. Detector dogs are useful for locating bed bugs because they use olfaction rather than vision. Dogs were trained to detect the bed bug (as few as one adult male or female) and viable bed bug eggs (five, collected 5-6 d after feeding) by using a modified food and verbal reward system. Their efficacy was tested with bed bugs and viable bed bug eggs placed in vented polyvinyl chloride containers. Dogs were able to discriminate bed bugs from Camponotus floridanus Buckley, Blattella germanica (L.), and Reticulitermes flavipes (Kollar), with a 97.5% positive indication rate (correct indication of bed bugs when present) and 0% false positives (incorrect indication of bed bugs when not present). Dogs also were able to discriminate live bed bugs and viable bed bug eggs from dead bed bugs, cast skins, and feces, with a 95% positive indication rate and a 3% false positive rate on bed bug feces. In a controlled experiment in hotel rooms, dogs were 98% accurate in locating live bed bugs. A pseudoscent prepared from pentane extraction of bed bugs was recognized by trained dogs as bed bug scent (100% indication). The pseudoscent could be used to facilitate detector dog training and quality assurance programs. If trained properly, dogs can be used effectively to locate live bed bugs and viable bed bug eggs.
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Questing activity in bed bug populations: male and female responses to host signals.
Aak, Anders; Rukke, Bjørn A; Soleng, Arnulf; Rosnes, Marte K
2014-09-01
A large-arena bioassay is used to examine sex differences in spatiotemporal patterns of bed bug Cimex lectularius L. behavioural responses to either a human host or CO 2 gas. After release in the centre of the arena, 90% of newly-fed bed bugs move to hiding places in the corners within 24 h. They require 3 days to settle down completely in the arena, with generally low activity levels and the absence of responses to human stimuli for 5 days. After 8-9 days, persistent responses can be recorded. Sex differences are observed, in which females are more active during establishment, respond faster after feeding, expose themselves more than males during the daytime, and respond more strongly to the host signal. The number of bed bugs that rest in harbourages is found to vary significantly according to light setting and sex. Both sexes stay inside harbourages more in daylight compared with night, and males hide more than females during the daytime but not during the night. The spatial distribution of the bed bugs is also found to change with the presence of CO 2 , and peak aggregation around the odour source is observed after 24 min. Both male and female bed bugs move from hiding places or the border of the arena toward the centre where CO 2 is released. Peak responses are always highest during the night. Bed bug behaviour and behaviour-regulating features are discussed in the context of control methods.
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Hinson, Kevin R; Reukov, Vladimir; Benson, Eric P; Zungoli, Patricia A; Bridges, William C; Ellis, Brittany R; Song, Jinbo
2017-01-01
We observed that teneral adults (<1 h post-molt) of Cimex lectularius L. appeared more adept at climbing a smooth surface compared to sclerotized adults. Differences in climbing ability on a smooth surface based on sclerotization status were quantified by measuring the height to which bed bugs climbed when confined within a glass vial. The average maximum height climbed by teneral (T) bed bugs (n = 30, height climbed = 4.69 cm) differed significantly (P< 0.01) from recently sclerotized (RS) bed bugs (n = 30, height climbed = 1.73 cm at ~48 h post molt), sclerotized group 1 (S1) bed bugs (n = 30, S1 = 2.42 cm at >72 h), and sclerotized group 2 (S2) bed bugs (n = 30, height climbed = 2.64 cm at >72 h post molt). When heights from all climbing events were summed, teneral bed bugs (650.8 cm climbed) differed significantly (P< 0.01) from recently sclerotized (82 cm climbed) and sclerotized (group 1 = 104.6 cm climbed, group 2 = 107.8 cm climbed) bed bugs. These findings suggested that the external surface of teneral bed bug exoskeletons possess an adhesive property. Using atomic force microscopy (AFM), we found that adhesion force of an exoskeletal (presumably molting) fluid decreased almost five-fold from 88 to 17 nN within an hour of molting. Our findings may have implications for laboratory safety and the effectiveness of bed bug traps, barriers, and biomimetic-based adhesives.
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Questing activity in bed bug populations: male and female responses to host signals
Aak, Anders; Rukke, Bjørn A; Soleng, Arnulf; Rosnes, Marte K
2014-01-01
A large-arena bioassay is used to examine sex differences in spatiotemporal patterns of bed bug Cimex lectularius L. behavioural responses to either a human host or CO2 gas. After release in the centre of the arena, 90% of newly-fed bed bugs move to hiding places in the corners within 24 h. They require 3 days to settle down completely in the arena, with generally low activity levels and the absence of responses to human stimuli for 5 days. After 8–9 days, persistent responses can be recorded. Sex differences are observed, in which females are more active during establishment, respond faster after feeding, expose themselves more than males during the daytime, and respond more strongly to the host signal. The number of bed bugs that rest in harbourages is found to vary significantly according to light setting and sex. Both sexes stay inside harbourages more in daylight compared with night, and males hide more than females during the daytime but not during the night. The spatial distribution of the bed bugs is also found to change with the presence of CO2, and peak aggregation around the odour source is observed after 24 min. Both male and female bed bugs move from hiding places or the border of the arena toward the centre where CO2 is released. Peak responses are always highest during the night. Bed bug behaviour and behaviour-regulating features are discussed in the context of control methods. PMID:26166936
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Comparison of Three Bed Bug Management Strategies in a Low-Income Apartment Building.
Wang, Changlu; Saltzmann, Kurt; Bennett, Gary; Gibb, Timothy
2012-04-02
Bed bug (Cimex lectularius L.) infestations are currently controlled by a variety of non-chemical and chemical methods. There have been few studies on the comparative effectiveness of these control techniques. We evaluated three bed bug management strategies in an apartment building: (1) non-chemical methods only (n = 9); (2) insecticides only (n = 6); and (3) integrated pest management including both non-chemical methods and insecticides (n = 9). The apartments were one-bedroom units occupied by seniors or people with disabilities. Bed bug numbers in each apartment were determined by visual inspection and/or installing intercepting devices under bed and sofa legs. The median (min, max) bed bug counts in the non-chemical methods only, insecticides only, and integrated pest management (IPM) treatment were: 4 (1, 57), 19 (1, 250), and 14 (1, 219), respectively prior to the treatments. The apartments were retreated if found necessary during biweekly to monthly inspections. After 10 weeks, bed bugs were found to be eliminated from 67, 33, and 44% of the apartments in the three treatment groups, respectively. The final (after 10 weeks) median (min, max) bed bug counts in the non-chemical methods only, insecticides only, and IPM treatment were: 0 (0, 134), 11.5 (0, 58), and 1 (0, 38), respectively. There were no significant differences in the speed of bed bug count reduction or the final bed bug counts. Lack of resident cooperation partially contributed to the failure in eliminating bed bugs from some of the apartments. Results of this study suggest that non-chemical methods can effectively eliminate bed bugs in lightly infested apartments.
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Zungoli, Patricia A.; Bridges, William C.; Ellis, Brittany R.; Song, Jinbo
2017-01-01
We observed that teneral adults (<1 h post-molt) of Cimex lectularius L. appeared more adept at climbing a smooth surface compared to sclerotized adults. Differences in climbing ability on a smooth surface based on sclerotization status were quantified by measuring the height to which bed bugs climbed when confined within a glass vial. The average maximum height climbed by teneral (T) bed bugs (n = 30, height climbed = 4.69 cm) differed significantly (P< 0.01) from recently sclerotized (RS) bed bugs (n = 30, height climbed = 1.73 cm at ~48 h post molt), sclerotized group 1 (S1) bed bugs (n = 30, S1 = 2.42 cm at >72 h), and sclerotized group 2 (S2) bed bugs (n = 30, height climbed = 2.64 cm at >72 h post molt). When heights from all climbing events were summed, teneral bed bugs (650.8 cm climbed) differed significantly (P< 0.01) from recently sclerotized (82 cm climbed) and sclerotized (group 1 = 104.6 cm climbed, group 2 = 107.8 cm climbed) bed bugs. These findings suggested that the external surface of teneral bed bug exoskeletons possess an adhesive property. Using atomic force microscopy (AFM), we found that adhesion force of an exoskeletal (presumably molting) fluid decreased almost five-fold from 88 to 17 nN within an hour of molting. Our findings may have implications for laboratory safety and the effectiveness of bed bug traps, barriers, and biomimetic-based adhesives. PMID:29244819
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Anderson, John F; Ferrandino, Francis J; Vasil, Michael P; Bedoukian, Robert H; Maher, Marie; McKenzie, Karen
2018-05-04
Bed bugs, Cimex lectularius L. (Hemiptera: Cimicidae), have become a major health nuisance in the past 20 ysin cities and elsewhere throughout many areas of the world. Few studies have reported on repellent compounds that could reduce their transport in luggage. We evaluated the repellency of six naturally occurring or related compounds used in flavor/fragrance applications or structurally related compounds, para-menthane-3,8-diol, and N,N-diethyl-meta-toluamide (DEET) to bed bugs in a 183 × 183-cm arena . Repellency was assessed using soft-sided polyester lunch bags serving as surrogates of luggage and barrier cloth towels upon which rested untreated lunch bags. We report for the first time repellency of delta dodecalactone, 2-(3, 7-dimethyl-2, 6-nonadien-1-yl)-cyclopentanone (a.k.a. 'methyl apritone'), gamma dodecalactone, and para-menthane-3,8-diol to bed bugs. Propyl dihydrojasmonate, 3-methyl-5-hexyl-2-cyclohexenone, gamma methyl tridecalactone, and DEET are also documented to be repellent to bed bugs. These compounds provided relatively long-term protection. Propyl dihydrojasmonate prevented bed bugs from seeking refuge in treated lunch bags 27 d after treatment, and when applied to cloth towels repelled harborage-seeking bed bugs for 146 d. Methyl apritone blended with 3-methyl-5-hexyl-2-cyclohexenone and delta dodecalactone as an individual compound applied to cloth towels repelled bed bugs for 190 and 276 d, respectively. The above-mentioned compounds, either individually or as blends, may reduce risk of bed bugs seeking harborage in treated suitcases or towels upon which untreated luggage is placed.
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Surveillance study of vector species on board passenger ships, Risk factors related to infestations
Mouchtouri, Varvara A; Anagnostopoulou, Rimma; Samanidou-Voyadjoglou, Anna; Theodoridou, Kalliopi; Hatzoglou, Chrissi; Kremastinou, Jenny; Hadjichristodoulou, Christos
2008-01-01
Background Passenger ships provide conditions suitable for the survival and growth of pest populations. Arthropods and rodents can gain access directly from the ships' open spaces, can be carried in shiploads, or can be found on humans or animals as ectoparasites. Vectors on board ships may contaminate stored foods, transmit illness on board, or, introduce diseases in new areas. Pest species, ship areas facilitating infestations, and different risk factors related to infestations were identified in 21 ferries. Methods 486 traps for insects and rodents were placed in 21 ferries. Archives of Public Health Authorities were reviewed to identify complaints regarding the presence of pest species on board ferries from 1994 to 2004. A detail questionnaire was used to collect data on ship characteristics and pest control practices. Results Eighteen ferries were infested with flies (85.7%), 11 with cockroaches (52.3%), three with bedbugs, and one with fleas. Other species had been found on board were ants, spiders, butterflies, beetles, and a lizard. A total of 431 Blattella germanica species were captured in 28 (9.96%) traps, and 84.2% of them were nymphs. One ship was highly infested. Cockroach infestation was negatively associated with ferries in which Hazard Analysis Critical Control Point system was applied to ensure food safety on board (Relative Risk, RR = 0.23, p = 0.03), and positively associated with ferries in which cockroaches were observed by crew (RR = 4.09, p = 0.007), no cockroach monitoring log was kept (RR = 5.00, p = 0.02), and pesticide sprays for domestic use were applied by crew (RR = 4.00, p = 0.05). Cockroach infested ships had higher age (p = 0.03). Neither rats nor mice were found on any ship, but three ferries had been infested with a rodent in the past. Conclusion Integrated pest control programs should include continuing monitoring for a variety of pest species in different ship locations; pest control measures should be more persistent in older ships. HACCP system aids in the prevention of cockroach infestations on board. PMID:18371217
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Surveillance study of vector species on board passenger ships, risk factors related to infestations.
Mouchtouri, Varvara A; Anagnostopoulou, Rimma; Samanidou-Voyadjoglou, Anna; Theodoridou, Kalliopi; Hatzoglou, Chrissi; Kremastinou, Jenny; Hadjichristodoulou, Christos
2008-03-27
Passenger ships provide conditions suitable for the survival and growth of pest populations. Arthropods and rodents can gain access directly from the ships' open spaces, can be carried in shiploads, or can be found on humans or animals as ectoparasites. Vectors on board ships may contaminate stored foods, transmit illness on board, or, introduce diseases in new areas. Pest species, ship areas facilitating infestations, and different risk factors related to infestations were identified in 21 ferries. 486 traps for insects and rodents were placed in 21 ferries. Archives of Public Health Authorities were reviewed to identify complaints regarding the presence of pest species on board ferries from 1994 to 2004. A detail questionnaire was used to collect data on ship characteristics and pest control practices. Eighteen ferries were infested with flies (85.7%), 11 with cockroaches (52.3%), three with bedbugs, and one with fleas. Other species had been found on board were ants, spiders, butterflies, beetles, and a lizard. A total of 431 Blattella germanica species were captured in 28 (9.96%) traps, and 84.2% of them were nymphs. One ship was highly infested. Cockroach infestation was negatively associated with ferries in which Hazard Analysis Critical Control Point system was applied to ensure food safety on board (Relative Risk, RR = 0.23, p = 0.03), and positively associated with ferries in which cockroaches were observed by crew (RR = 4.09, p = 0.007), no cockroach monitoring log was kept (RR = 5.00, p = 0.02), and pesticide sprays for domestic use were applied by crew (RR = 4.00, p = 0.05). Cockroach infested ships had higher age (p = 0.03). Neither rats nor mice were found on any ship, but three ferries had been infested with a rodent in the past. Integrated pest control programs should include continuing monitoring for a variety of pest species in different ship locations; pest control measures should be more persistent in older ships. HACCP system aids in the prevention of cockroach infestations on board.
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Ashbrook, Aaron R; Scharf, Michael E; Bennett, Gary W; Gondhalekar, Ameya D
2017-06-01
Insecticide resistance is a major impediment for effective control of Cimex lectularius L. Previous resistance detection studies with bed bugs have focused on certain pyrethroid, neonicotinoid, organochlorine, organophosphate, and carbamate insecticides. Within the pyrethroid class, resistance studies have mostly been limited to deltamethrin, lambda-cyhalothrin, and alpha- and beta-cyfluthrin. The goal of this study was to develop diagnostic concentration bioassays for assessing bed bug susceptibility levels to chlorfenapyr- and bifenthrin-containing products. First, glass vial and filter paper bioassay methods were compared for their utility in susceptibility monitoring. Statistical comparison of toxicity data between bioassays indicated that the vial assay was less confounded by assay susbtrate effects, required less insecticide, and was faster, especially for chlorfenapyr. Next, using vial diagnostic concentrations (LC99) for each insecticide, 10 laboratory-adapted field strains and the Harlan lab-susceptible strain were screened for susceptibility to chlorfenapyr and bifenthrin. The results of this study reveal recent bed bug susceptibility levels to certain chlorfenapyr- and bifenthrin-containing products. Reduced susceptibility was detected in three and five field strains to chlorfenapyr and bifenthrin, respectively. Detection of reduced susceptibility suggests that certain strains may be segregating toward greater chlorfenapyr and bifenthrin resistance. These results merit continuous resistance monitoring efforts to detect chlorfenapyr and bifenthrin susceptibility shifts. Additionally, to reduce insecticide selection pressures and delay resistance development, adoption of integrated bed bug control strategies that combine chemical and nonchemical methods is recommended. © The Authors 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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Cooper, Richard; Wang, Changlu; Singh, Narinderpal
2016-04-01
Two experiments were conducted to evaluate the effects of various interventions on low-level bed bug, Cimex lectularius L., populations in occupied apartments. The first experiment was conducted in occupied apartments under three intervention conditions: never treated (Group I), recently treated with no further treatment (Group II), and recently treated with continued treatment (Group III). Each apartment was monitored with pitfall-style traps (interceptors) installed at beds and upholstered furniture (sleeping and resting areas) along with ∼18 additional interceptors throughout the apartment. The traps were inspected every 2 wk. After 22 wk, bed bugs had been eliminated (zero trap catch for eight consecutive weeks and none detected in visual inspections) in 96, 87, and 100% of the apartments in Groups I, II, and III, respectively. The second experiment investigated the impact of interceptors as a control measure in apartments with low-level infestations. In the treatment group, interceptors were continuously installed at and away from sleeping and resting areas and were inspected every 2 wk for 16 wk. In the control group, interceptors were placed in a similar fashion as the treatment group but were only placed during 6–8 and 14–16 wk to obtain bed bug counts. Bed bug counts were significantly lower at 8 wk in the treatment group than in the control group. At 16 wk, bed bugs were eliminated in 50% of the apartments in the treatment group. The implications of our results in the development of bed bug management strategies and monitoring protocols are discussed.
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Jones, Susan C; Bryant, Joshua L; Sivakoff, Frances S
2015-05-01
Sublethal exposure to pesticides can alter insect behavior with potential for population-level consequences. We investigated sublethal effects of ActiveGuard, a permethrin-impregnated fabric, on feeding behavior and fecundity of bed bugs (Cimex lectularius L.) from five populations that ranged from susceptible to highly pyrethroid resistant. After exposure to ActiveGuard fabric or untreated fabric for 1 or 10 min, adult virgin female bed bugs were individually observed when offered a blood meal to determine feeding attempts and weight gain. Because bed bug feeding behavior is tightly coupled with its fecundity, all females were then mated, and the number of eggs laid and egg hatch rate were used as fecundity measures. We observed that pyrethroid-resistant and -susceptible bugs were not significantly different for all feeding and fecundity parameters. Bed bugs exposed to ActiveGuard for 10 min were significantly less likely to attempt to feed or successfully feed, and their average blood meal size was significantly smaller compared with individuals in all other groups. Independent of whether or not feeding occurred, females exposed to ActiveGuard for 10 min were significantly more likely to lay no eggs. Only a single female exposed to ActiveGuard for 10 min laid any eggs. Among the other fabric treatment-exposure time groups, there were no observable differences in egg numbers or hatch rates. Brief exposure of 10 min to ActiveGuard fabric appeared to decrease feeding and fecundity of pyrethroid-resistant and susceptible bed bugs, suggesting the potentially important role of sublethal exposure for the control of this ectoparasitic insect. © The Authors 2015. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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Comparison of Three Bed Bug Management Strategies in a Low-Income Apartment Building
Wang, Changlu; Saltzmann, Kurt; Bennett, Gary; Gibb, Timothy
2012-01-01
Bed bug (Cimex lectularius L.) infestations are currently controlled by a variety of non-chemical and chemical methods. There have been few studies on the comparative effectiveness of these control techniques. We evaluated three bed bug management strategies in an apartment building: (1) non-chemical methods only (n = 9); (2) insecticides only (n = 6); and (3) integrated pest management including both non-chemical methods and insecticides (n = 9). The apartments were one-bedroom units occupied by seniors or people with disabilities. Bed bug numbers in each apartment were determined by visual inspection and/or installing intercepting devices under bed and sofa legs. The median (min, max) bed bug counts in the non-chemical methods only, insecticides only, and integrated pest management (IPM) treatment were: 4 (1, 57), 19 (1, 250), and 14 (1, 219), respectively prior to the treatments. The apartments were retreated if found necessary during biweekly to monthly inspections. After 10 weeks, bed bugs were found to be eliminated from 67, 33, and 44% of the apartments in the three treatment groups, respectively. The final (after 10 weeks) median (min, max) bed bug counts in the non-chemical methods only, insecticides only, and IPM treatment were: 0 (0, 134), 11.5 (0, 58), and 1 (0, 38), respectively. There were no significant differences in the speed of bed bug count reduction or the final bed bug counts. Lack of resident cooperation partially contributed to the failure in eliminating bed bugs from some of the apartments. Results of this study suggest that non-chemical methods can effectively eliminate bed bugs in lightly infested apartments. PMID:26466533
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RNA-Seq and molecular docking reveal multi-level pesticide resistance in the bed bug
2012-01-01
Background Bed bugs (Cimex lectularius) are hematophagous nocturnal parasites of humans that have attained high impact status due to their worldwide resurgence. The sudden and rampant resurgence of C. lectularius has been attributed to numerous factors including frequent international travel, narrower pest management practices, and insecticide resistance. Results We performed a next-generation RNA sequencing (RNA-Seq) experiment to find differentially expressed genes between pesticide-resistant (PR) and pesticide-susceptible (PS) strains of C. lectularius. A reference transcriptome database of 51,492 expressed sequence tags (ESTs) was created by combining the databases derived from de novo assembled mRNA-Seq tags (30,404 ESTs) and our previous 454 pyrosequenced database (21,088 ESTs). The two-way GLMseq analysis revealed ~15,000 highly significant differentially expressed ESTs between the PR and PS strains. Among the top 5,000 differentially expressed ESTs, 109 putative defense genes (cuticular proteins, cytochrome P450s, antioxidant genes, ABC transporters, glutathione S-transferases, carboxylesterases and acetyl cholinesterase) involved in penetration resistance and metabolic resistance were identified. Tissue and development-specific expression of P450 CYP3 clan members showed high mRNA levels in the cuticle, Malpighian tubules, and midgut; and in early instar nymphs, respectively. Lastly, molecular modeling and docking of a candidate cytochrome P450 (CYP397A1V2) revealed the flexibility of the deduced protein to metabolize a broad range of insecticide substrates including DDT, deltamethrin, permethrin, and imidacloprid. Conclusions We developed significant molecular resources for C. lectularius putatively involved in metabolic resistance as well as those participating in other modes of insecticide resistance. RNA-Seq profiles of PR strains combined with tissue-specific profiles and molecular docking revealed multi-level insecticide resistance in C. lectularius. Future research that is targeted towards RNA interference (RNAi) on the identified metabolic targets such as cytochrome P450s and cuticular proteins could lay the foundation for a better understanding of the genetic basis of insecticide resistance in C. lectularius. PMID:22226239
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Wang, Changlu; Gibb, Timothy; Bennett, Gary W
2009-05-01
The cost and effectiveness of two bed bug (Cimex lectularius L.) integrated pest management (IPM) programs were evaluated for 10 wk. Sixteen bed bug-infested apartments were chosen from a high-rise low-income apartment building. The apartments were randomly divided into two treatment groups: diatomaceous earth dust-based IPM (D-IPM) and chlorfenapyr spray-based IPM (S-IPM). The initial median (minimum, maximum) bed bug counts (by visual inspection) of the two treatment groups were 73.5 (10, 352) and 77 (18, 3025), respectively. A seminar and an educational brochure were delivered to residents and staff. It was followed by installing encasements on mattresses and box springs and applying hot steam to bed bug-infested areas in all 16 apartments. Diatomaceous earth dust (Mother Earth-D) was applied in the D-IPM group 2 d after steaming. In addition, bed bug-intercepting devices were installed under legs of infested beds or sofas or chairs to intercept bed bugs. The S-IPM group only received 0.5% chlorfenapyr spray (Phantom) after the nonchemical treatments. All apartments were monitored bi-weekly and retreated when necessary. After 10 wk, bed bugs were eradicated from 50% of the apartments in each group. Bed bug count reduction (mean +/- SEM) was 97.6 +/- 1.6 and 89.7 +/- 7.3% in the D-IPM and S-IPM groups, respectively. Mean treatment costs in the 10-wk period were $463 and $482 per apartment in the D-IPM and S-IPM groups, respectively. Bed bug interceptors trapped an average of 219 +/- 135 bed bugs per apartment in 10 wk. The interceptors contributed to the IPM program efficacy and were much more effective than visual inspections in estimating bed bug numbers and determining the existence of bed bug infestations.
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Effectiveness of bed bug monitors for detecting and trapping bed bugs in apartments.
Wang, Changlu; Tsai, Wan-Tien; Cooper, Richard; White, Jeffrey
2011-02-01
Bed bugs, Cimex lectularius L., are now considered a serious urban pest in the United States. Because they are small and difficult to find, there has been strong interest in developing and using monitoring tools to detect bed bugs and evaluate the results of bed bug control efforts. Several bed bug monitoring devices were developed recently, but their effectiveness is unknown. We comparatively evaluated three active monitors that contain attractants: CDC3000, NightWatch, and a home-made dry ice trap. The Climbup Insect Interceptor, a passive monitor (without attractants), was used for estimating the bed bug numbers before and after placing active monitors. The results of the Interceptors also were compared with the results of the active monitors. In occupied apartments, the relative effectiveness of the active monitors was: dry ice trap > CDC3000 > NightWatch. In lightly infested apartments, the Interceptor (operated for 7 d) trapped similar number of bed bugs as the dry ice trap (operated for 1 d) and trapped more bed bugs than CDC3000 and NightWatch (operated for 1 d). The Interceptor was also more effective than visual inspections in detecting the presence of small numbers of bed bugs. CDC3000 and the dry ice trap operated for 1 d were equally as effective as the visual inspections for detecting very low level of infestations, whereas 1-d deployment of NightWatch detected significantly lower number of infestations compared with visual inspections. NightWatch was designed to be able to operate for several consecutive nights. When operated for four nights, NightWatch trapped similar number of bed bugs as the Interceptors operated for 10 d after deployment of NightWatch. We conclude these monitors are effective tools in detecting early bed bug infestations and evaluating the results of bed bug control programs.
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Leulmi, Hamza; Bitam, Idir; Berenger, Jean Michel; Lepidi, Hubert; Rolain, Jean Marc; Almeras, Lionel; Raoult, Didier; Parola, Philippe
2015-01-01
Background Bartonella quintana, the etiologic agent of trench fever and other human diseases, is transmitted by the feces of body lice. Recently, this bacterium has been detected in other arthropod families such as bed bugs, which begs the question of their involvement in B. quintana transmission. Although several infectious pathogens have been reported and are suggested to be transmitted by bed bugs, the evidence regarding their competence as vectors is unclear. Methodology/Principal Findings Bed bugs at the adult and instar developmental stages were fed three successive human blood meals inoculated with B. quintana bacterium from day one (D1) to D5; subsequently they were fed with pathogen-free human blood until the end of the experiment. Bed bugs and feces were collected in time series, to evaluate their capacities to acquire, multiply and expel viable B. quintana using molecular biology, immunohistochemistry and cultures assays. B. quintana was detected molecularly in 100% of randomly selected experimentally infected bed bug specimens (D3). The monitoring of B. quintana in bed bug feces showed that the bacterium was detectable starting on the 3rd day post-infection (pi) and persisted until day 18±1 pi. Although immunohistochemistry assays localized the bacteria to the gastrointestinal bed bug gut, the detection of B. quintana in the first and second instar larva stages suggested a vertical non-transovarial transmission of the bacterium. Conclusion The present work demonstrated for the first time that bed bugs can acquire, maintain for more than 2 weeks and release viable B. quintana organisms following a stercorarial shedding. We also observed the vertical transmission of the bacterium to their progeny. Although the biological role of bed bugs in the transmission of B. quintana under natural conditions has yet to be confirmed, the present work highlights the need to reconsider monitoring of these arthropods for the transmission of human pathogens. PMID:26000974
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Zhang, Yueliang; Wang, Yaming; Wang, Lihua; Yao, Jing; Guo, Huifang; Fang, Jichao
2016-02-01
NADPH-cytochrome P450 reductase (CPR) plays an important role in cytochrome P450 function, and CPR knockdown in several insects leads to increased susceptibility to insecticides. However, a putative CPR gene has not yet been fully characterized in the small brown planthopper Laodelphax striatellus, a notorious agricultural pest in rice that causes serious damage by transmitting rice stripe and rice black-streaked dwarf viruses. The objective of this study was to clone the cDNA and to knock down the expression of the gene that encodes L. striatellus CPR (LsCPR) to further determine whether P450s are involved in the resistance of L. striatellus to buprofezin. First, the full-length cDNA of LsCPR was cloned and found to contain an open reading frame (ORF) encoding a polypeptide of 679 amino acids with a calculated molecular mass and isoelectric point of 76.92kDa and 5.37, respectively. The deduced amino acid sequence shares high identity with the CPRs of other insects (98%, 97%, 75% and 68% for Sogatella furcifera, Nilaparvata lugens, Cimex lectularius and Anopheles gambiae, respectively) and possesses the characteristic features of classical CPRs, such as an N-terminal membrane anchor and conserved domains for flavin mononucleotide (FMN), flavin adenine dinucleotide (FAD) and nicotinamide adenine dinucleotide phosphate (NADPH) binding. Phylogenetic analysis revealed that LsCPR is located in a branch along with the CPRs of other hemipteran insects. LsCPR mRNA was detectable in all examined body parts and developmental stages of L. striatellus, as determined by real-time quantitative PCR (qPCR), and transcripts were most abundant in the adult abdomen and in first-instar nymphs and adults. Ingestion of 200μg/mL of LsCPR double-stranded RNA (dsLsCPR) by the planthopper for 5days significantly reduced the transcription level of LsCPR. Moreover, silencing of LsCPR caused increased susceptibility to buprofezin in a buprofezin-resistant (YN-BPF) strain but not in a susceptible (YN) strain. These data further suggested that the P450-mediated metabolic detoxification of xenobiotics might be an important mechanism for buprofezin resistance in L. striatellus. Copyright © 2015 Elsevier B.V. All rights reserved.
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[Prevention and control of leishmaniasis vectors: current approaches].
Maroli, M; Khoury, C
2004-06-01
Phlebotomine sandflies (Diptera: Psychodidae) are the suspected or proven vectors of Leishmania spp. in at least 88 countries, including over 40 Phlebotomus species in the Old World and a further 30 belonging to the genus Lutzomyia in the New World. In recent years, both cutaneous (CL) and zoonotic visceral leishmaniasis (ZVL) have become increasingly prevalent in urban areas, including large Latin American cities. A similar trend has been recorded in all Mediterranean areas during the last decade. Based on mathematical models, insecticidal control of sandflies appears to represent a more effective way of reducing Leishmania infantum transmission than the present strategy of culling infected dogs in Latin America as well as being more acceptable to the human population. Since man is a dead-end host of most Leishmania species, treatment of existing human cases generally does not affect transmission. Interruption of the cycle by vector control may offer a cheaper, more practical solution to treatment and improved knowledge of the alternatives available could lead to preventative measures being undertaken in more leishmaniasis foci. In this note a review of current knowledge on sandfly control is presented. Different measures to control phlebotomine sandflies, including residual spraying of dwellings and animal shelters, insecticide treated nets, application of repellents/insecticides to skin or to fabrics and impregnated dog collars are discussed. Although effective in urban areas with high concentrations of sandflies, residual spraying of insecticides is no often longer tenable in most situations. In rural areas where dwellings are more dispersed and surrounded by large, untargeted "reservoir" populations of sandflies, residual spraying of houses may be both impractical for logistic reasons and ineffective. Actually, this control measure depends on the availability of a suitable public health infrastructure, including adequate supplies of insecticide, spraying equipment and trained personnel. Ideally such personnel should be trained in insecticide application, monitoring techniques and interpretation of sampling data, as well as safety techniques. To date reports of resistance refer to one insecticide (DDT) in only three species (Phlebotomus papatasi, P. argentipes and Sergentomyia shorti) in one country (India), although there are reports of increased tolerance to this compound in several countries. Fortunately the insects remain susceptible to all the major insecticidal groups. Impregnated bednets may offer the best solution in rural areas where transmission is largely intradomiciliary. This measure has the advantage that it can be employed at the individual household level and affords collateral benefits such as privacy and control of other biting insects such as mosquitoes, fleas and bedbugs. Sandfly larvae are generally difficult to find in nature so control measures that act specifically against immatures are not feasible, although the effectiveness of a few biological and chemical agents has been demonstrated in laboratory evaluations. In ZVL foci, where dogs are the unique domestic reservoir, a reduction in Leishmania transmission would be expected if we could combine an effective mass treatment of infected dogs with a protection of both healthy and infected dogs from the sandfly bites. Laboratory and field evaluations have shown that impregnated dog collars and topical application of insecticides could protect dogs from most sandfly bites by means of both anti-feeding and killing effect of the pirethorids used.
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Common Cause Failures and Ultra Reliability
NASA Technical Reports Server (NTRS)
Jones, Harry W.
2012-01-01
A common cause failure occurs when several failures have the same origin. Common cause failures are either common event failures, where the cause is a single external event, or common mode failures, where two systems fail in the same way for the same reason. Common mode failures can occur at different times because of a design defect or a repeated external event. Common event failures reduce the reliability of on-line redundant systems but not of systems using off-line spare parts. Common mode failures reduce the dependability of systems using off-line spare parts and on-line redundancy.
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Leading the Common Core State Standards: From Common Sense to Common Practice
ERIC Educational Resources Information Center
Dunkle, Cheryl A.
2012-01-01
Many educators agree that we already know how to foster student success, so what is keeping common sense from becoming common practice? The author provides step-by-step guidance for overcoming the barriers to adopting the Common Core State Standards (CCSS) and achieving equity and excellence for all students. As an experienced teacher and…
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29 CFR 779.219 - Unified operation may be achieved without common control or common ownership.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 29 Labor 3 2010-07-01 2010-07-01 false Unified operation may be achieved without common control or... Act May Apply; Enterprise Coverage Unified Operation Or Common Control § 779.219 Unified operation may be achieved without common control or common ownership. The performance of related activities through...
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NASA Astrophysics Data System (ADS)
Blanco, J. M.; Zhukov, A. P.; González, J.
1999-12-01
The magneto-impedance effect icons/Journals/Common/Delta" ALT="Delta" ALIGN="TOP"/> Z/ZH = [Z(H)-Z(Hmax)]/Z(Hmax) has been measured in (Fe0.95Co0.05)72.5B15Si12.5 wire under torsion stress, icons/Journals/Common/xi" ALT="xi" ALIGN="TOP"/> (torsion angle per unit length) with axial magnetic field (H) as parameter. Without stress (icons/Journals/Common/Delta" ALT="Delta" ALIGN="TOP"/> Z/Z)H(H) dependence has a non-monotonous shape with first an increase of total impedance Z and then a decrease, i.e. shows a maximum at certain axial magnetic field Hm. It was found that the torsion stress dependence of electrical impedance (torsion impedance), (icons/Journals/Common/Delta" ALT="Delta" ALIGN="TOP"/> Z/Z)icons/Journals/Common/xi" ALT="xi" ALIGN="MIDDLE"/> = [Z(icons/Journals/Common/xi" ALT="xi" ALIGN="TOP"/>)-Z(icons/Journals/Common/xi" ALT="xi" ALIGN="TOP"/>max)]/Z(icons/Journals/Common/xi" ALT="xi" ALIGN="TOP"/>max), has asymmetric character with a clear maximum at torsion angle, icons/Journals/Common/xi" ALT="xi" ALIGN="TOP"/> around 7icons/Journals/Common/pi" ALT="pi" ALIGN="TOP"/> rad m-1 in as-cast wire, while (icons/Journals/Common/Delta" ALT="Delta" ALIGN="TOP"/> Z/Z)icons/Journals/Common/xi" ALT="xi" ALIGN="MIDDLE"/> reaches a maximum around 170%. Thermal treatments under torsion stress (without and with a previous annealing stage) develop a helical anisotropy on the amorphous wire, which drastically modifies the (icons/Journals/Common/Delta" ALT="Delta" ALIGN="TOP"/> Z/Z)icons/Journals/Common/xi" ALT="xi" ALIGN="MIDDLE"/> response. Such treatments were carried out by using current annealing which resulted in a drastic increase of the maximum (icons/Journals/Common/Delta" ALT="Delta" ALIGN="TOP"/> Z/Z)icons/Journals/Common/xi" ALT="xi" ALIGN="MIDDLE"/> up to 225%, and a change of torsion dependence of icons/Journals/Common/Delta" ALT="Delta" ALIGN="TOP"/> Z/Z with a tendency to a finally symmetric dependence of (icons/Journals/Common/Delta" ALT="Delta" ALIGN="TOP"/> Z/Z)icons/Journals/Common/xi" ALT="xi" ALIGN="MIDDLE"/>(icons/Journals/Common/xi" ALT="xi" ALIGN="TOP"/>). The maximum (icons/Journals/Common/Delta" ALT="Delta" ALIGN="TOP"/> Z/Z)icons/Journals/Common/xi" ALT="xi" ALIGN="MIDDLE"/> ratio, (icons/Journals/Common/Delta" ALT="Delta" ALIGN="TOP"/> Z/Z)icons/Journals/Common/xi" ALT="xi" ALIGN="TOP"/> m, was obtained under torsion stress of icons/Journals/Common/xi" ALT="xi" ALIGN="TOP"/> = 20icons/Journals/Common/pi" ALT="pi" ALIGN="TOP"/> rad m-1 (in a torsion annealed sample) and
= 11
rad m-1 (with pre-annealing and torsion annealing). Observed dependences were explained taking into account the frozen-in magneto-elastic anisotropy owing to the internal stress distribution during the fabrication process, the helical anisotropies induced by the torsion strain and that developed by thermal treatment under torsion stress (torsion annealing). The differences in the shape and intensity of the maximum (
Z/Z) m between the torsion annealed and pre-annealed and torsion annealed samples should be ascribed to the visco-elastic character of the helical anisotropy induced by torsion stress. -
2011-01-01
Background Common carp is one of the most important aquaculture teleost fish in the world. Common carp and other closely related Cyprinidae species provide over 30% aquaculture production in the world. However, common carp genomic resources are still relatively underdeveloped. BAC end sequences (BES) are important resources for genome research on BAC-anchored genetic marker development, linkage map and physical map integration, and whole genome sequence assembling and scaffolding. Result To develop such valuable resources in common carp (Cyprinus carpio), a total of 40,224 BAC clones were sequenced on both ends, generating 65,720 clean BES with an average read length of 647 bp after sequence processing, representing 42,522,168 bp or 2.5% of common carp genome. The first survey of common carp genome was conducted with various bioinformatics tools. The common carp genome contains over 17.3% of repetitive elements with GC content of 36.8% and 518 transposon ORFs. To identify and develop BAC-anchored microsatellite markers, a total of 13,581 microsatellites were detected from 10,355 BES. The coding region of 7,127 genes were recognized from 9,443 BES on 7,453 BACs, with 1,990 BACs have genes on both ends. To evaluate the similarity to the genome of closely related zebrafish, BES of common carp were aligned against zebrafish genome. A total of 39,335 BES of common carp have conserved homologs on zebrafish genome which demonstrated the high similarity between zebrafish and common carp genomes, indicating the feasibility of comparative mapping between zebrafish and common carp once we have physical map of common carp. Conclusion BAC end sequences are great resources for the first genome wide survey of common carp. The repetitive DNA was estimated to be approximate 28% of common carp genome, indicating the higher complexity of the genome. Comparative analysis had mapped around 40,000 BES to zebrafish genome and established over 3,100 microsyntenies, covering over 50% of the zebrafish genome. BES of common carp are tremendous tools for comparative mapping between the two closely related species, zebrafish and common carp, which should facilitate both structural and functional genome analysis in common carp. PMID:21492448
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ERIC Educational Resources Information Center
Perry, Rebecca R.; Finkelstein, Neal D.; Seago, Nanette; Heredia, Alberto; Sobolew-Shubin, Sandy; Carroll, Cathy
2015-01-01
Math in Common® (MiC) is a five-year initiative that supports a formal network of 10 California school districts as they implement the Common Core State Standards in Mathematics (CCSS-M) across grades K-8. In spring 2015, WestEd administered surveys to understand the perspectives on Common Core State Standards-Mathematics (CCSS-M) implementation…
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Presentation of structural component designs for the family of commuter airplanes
NASA Technical Reports Server (NTRS)
Russell, Mark; Haddad, Raphael; Creighton, Tom; Hendrich, Louis; Hensley, Doug; Morgan, Louise; Swift, Jerry
1987-01-01
The purpose is to present the implementation of structural commonality in the family of commuter airplanes. One of the main goals is implementation of structural commonality to as high a degree as possible. The structural layouts of those parts of the airplanes in which commonality is possible with all members of the family will be presented. The following airplane sections, which are common on all of the airplanes in the family, will be presented: common nose cone design; common wing torque box design; and common tail cone design. A proposed production and manufacturing breakdown is described. The advantages and disadvantages of implementing structural commonality and recommendations for further work will be discussed.
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Marriage and Family Therapy Students' Experience with Common Factors Training.
Fife, Stephen T; D'Aniello, Carissa; Scott, Sarah; Sullivan, Erin
2018-04-27
With the increased empirical and theoretical support for common factors in the psychotherapy literature, marriage and family therapy (MFT) scholars have begun discussing the inclusion of common factors in MFT training. However, there is very little empirical research on common factors training or how to include common factors in MFT curricula. The purpose of this phenomenological study was to investigate MFT students' experience with common factors training. Seventeen master's degree students who received training in common factors participated in the study. Data was comprised of participants' journal reflections and focus group interviews on their experience learning about common factors and how this influenced their work with clients. Participants' responses to the training were overwhelmingly positive and highlighted the ways in which studying common factors enhanced their confidence, understanding of MFT models, conceptual abilities, and clinical practice. Additional results and discussion about incorporating common factors in MFT training are presented. © 2018 American Association for Marriage and Family Therapy.
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Justifying group-specific common morality.
Strong, Carson
2008-01-01
Some defenders of the view that there is a common morality have conceived such morality as being universal, in the sense of extending across all cultures and times. Those who deny the existence of such a common morality often argue that the universality claim is implausible. Defense of common morality must take account of the distinction between descriptive and normative claims that there is a common morality. This essay considers these claims separately and identifies the nature of the arguments for each claim. It argues that the claim that there is a universal common morality in the descriptive sense has not been successfully defended to date. It maintains that the claim that there is a common morality in the normative sense need not be understood as universalist. This paper advocates the concept of group specific common morality, including country-specific versions. It suggests that both the descriptive and the normative claims that there are country-specific common moralities are plausible, and that a country-specific normative common morality could provide the basis for a country's bioethics.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Darby, John L.
2011-05-01
As the nuclear weapon stockpile ages, there is increased concern about common degradation ultimately leading to common cause failure of multiple weapons that could significantly impact reliability or safety. Current acceptable limits for the reliability and safety of a weapon are based on upper limits on the probability of failure of an individual item, assuming that failures among items are independent. We expanded the current acceptable limits to apply to situations with common cause failure. Then, we developed a simple screening process to quickly assess the importance of observed common degradation for both reliability and safety to determine if furthermore » action is necessary. The screening process conservatively assumes that common degradation is common cause failure. For a population with between 100 and 5000 items we applied the screening process and conclude the following. In general, for a reliability requirement specified in the Military Characteristics (MCs) for a specific weapon system, common degradation is of concern if more than 100(1-x)% of the weapons are susceptible to common degradation, where x is the required reliability expressed as a fraction. Common degradation is of concern for the safety of a weapon subsystem if more than 0.1% of the population is susceptible to common degradation. Common degradation is of concern for the safety of a weapon component or overall weapon system if two or more components/weapons in the population are susceptible to degradation. Finally, we developed a technique for detailed evaluation of common degradation leading to common cause failure for situations that are determined to be of concern using the screening process. The detailed evaluation requires that best estimates of common cause and independent failure probabilities be produced. Using these techniques, observed common degradation can be evaluated for effects on reliability and safety.« less
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Grossman, Robert L.; Heath, Allison; Murphy, Mark; Patterson, Maria; Wells, Walt
2017-01-01
Data commons collocate data, storage, and computing infrastructure with core services and commonly used tools and applications for managing, analyzing, and sharing data to create an interoperable resource for the research community. An architecture for data commons is described, as well as some lessons learned from operating several large-scale data commons. PMID:29033693
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76 FR 12358 - Common Formats for Patient Safety Data Collection and Event Reporting
Federal Register 2010, 2011, 2012, 2013, 2014
2011-03-07
... HHS, AHRQ coordinates the development of a set of common definitions and reporting formats (Common... unsafe conditions that increase risks and hazards to patients. Definitions and other details about PSOs... hospitals and skilled nursing facilities. Definition of Common Formats The term ``Common Formats'' refers to...
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THE COMMON MARKET AND EUROPEAN UNIFICATION,
A study of the Common Market ; its past problems, current difficulties, and future possibilities are presented. The study consists of seven sections...each of which may be read independently: (1) an introduction to the Common Market ; (2) the Common Market and internal trade; (3) external economic...European Economic Community agriculture; and (7) the Common Market and European political unification. Statistical tables showing import and export data of the Common Market countries are appended. (Author)
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Is the common cold a clinical entity or a cultural concept?
Eccles, R
2013-03-01
Common cold is the most common infectious disease of mankind and the term is widely used in the clinical literature as though it were a defined clinical syndrome. Clinical studies on this syndrome often use elaborate symptom scoring systems to diagnose a common cold. The symptom scores are based on a study conducted over 50 years ago to retrospectively diagnose experimental cold and this method cannot be applied to diagnosis of common cold in the community. Diagnosis of the common cold by virology is not feasible because of the number of viruses and the variability in the disease states caused by the viruses. Because of the familiarity of subjects with common cold and the variability in symptomatology it seems a more reasonable approach to use self-diagnosis of common cold for clinical research studies and accept that the common cold is a cultural concept and not a clinical entity.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Burdick, G.R.; Wilson, J.R.
COMCAN2A and COMCAN are designed to analyze complex systems such as nuclear plants for common causes of failure. A common cause event, or common mode failure, is a secondary cause that could contribute to the failure of more than one component and violates the assumption of independence. Analysis of such events is an integral part of system reliability and safety analysis. A significant common cause event is a secondary cause common to all basic events in one or more minimal cut sets. Minimal cut sets containing events from components sharing a common location or a common link are called commonmore » cause candidates. Components share a common location if no barrier insulates any one of them from the secondary cause. A common link is a dependency among components which cannot be removed by a physical barrier (e.g., a common energy source or common maintenance instructions).IBM360;CDC CYBER176,175; FORTRAN IV (30%) and BAL (70%) (IBM360), FORTRAN IV (97%) and COMPASS (3%) (CDC CYBER176).; OS/360 (IBM360) and NOS/BE 1.4 (CDC CYBER176), NOS 1.3 (CDC CYBER175); 140K bytes of memory for COMCAN and 242K (octal) words of memory for COMCAN2A.« less
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NASA Technical Reports Server (NTRS)
Hark, Frank; Britton, Paul; Ring, Robert; Novack, Steven
2015-01-01
Space Launch System (SLS) Agenda: Objective; Key Definitions; Calculating Common Cause; Examples; Defense against Common Cause; Impact of varied Common Cause Failure (CCF) and abortability; Response Surface for various CCF Beta; Takeaways.
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... care unit (NICU) > Common NICU equipment Common NICU equipment E-mail to a friend Please fill in ... understand how they can help your baby. What equipment is commonly used in the NICU? Providers use ...
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COMCAN: a computer program for common cause analysis
DOE Office of Scientific and Technical Information (OSTI.GOV)
Burdick, G.R.; Marshall, N.H.; Wilson, J.R.
1976-05-01
The computer program, COMCAN, searches the fault tree minimal cut sets for shared susceptibility to various secondary events (common causes) and common links between components. In the case of common causes, a location check may also be performed by COMCAN to determine whether barriers to the common cause exist between components. The program can locate common manufacturers of components having events in the same minimal cut set. A relative ranking scheme for secondary event susceptibility is included in the program.
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ERIC Educational Resources Information Center
He, Yong
2013-01-01
Common test items play an important role in equating multiple test forms under the common-item nonequivalent groups design. Inconsistent item parameter estimates among common items can lead to large bias in equated scores for IRT true score equating. Current methods extensively focus on detection and elimination of outlying common items, which…
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USDA-ARS?s Scientific Manuscript database
Aphid-transmitted Bean Common Mosaic Necrosis Virus (BCMNV) and Bean Common Mosaic Virus (BCMV) are potyvirus that cause production losses in common and tepary beans. Developing resistance to viruses, specifically BCMV, BCMNV and BGYMV, will be critical for expanding tepary bean production. This stu...
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A Critique of "The Common Core Is a Change for the Better"
ERIC Educational Resources Information Center
Wolfe, Adam
2015-01-01
In their article, "The Common Core is a Change for the Better," Gardner and Powell (2013) make an argument in support of implementing the Common Core to improve teaching and student learning. They opine the Common Core will enable students to become more college and career ready and state the Common Core standards will provide…
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[A survey of knowledge on common cold in outpatient clinics].
Liu, Guo-liang; Lin, Jiang-tao; Liu, Guan-jian; Lin, Yan-ping; Yin, Kai-sheng; Bai, Chun-xue; Ma, Li-jun; Qiu, Chen; Liu, Chun-tao; Chen, Ming-wei; Liu, Hua; Chen, Ping
2012-04-01
To investigate outpatients' cognition towards common cold and their habituated medication so as to provide evidence for future public healthcare education. Patients who attended hospital for diagnosis and treatment of common cold at least within past three months were asked to fill a questionnaire independently so as to learn their cognition towards common cold and medication habit. Among the patients underwent survey, 52.21% had incorrect knowledge about common cold; 12.99% didn't know about the hazards of common cold; 34.80% couldn't distinguish common cold from influenza; 30.07% considered common cold couldn't get relief without treatment; 68.24% didn't know about the proper effects of influenza vaccination; 61.14% often took oral medicine even intravenous injection when they caught a common cold; 59.77% often took medication from drugstore without prescription by doctor, and a few asked doctors to prescribe medicine on their request; 19.42% didn't know about the side effects of drug for cold treatment; and 19.72% didn't know about the active ingredients of drug for cold treatment. There were significant differences in the common cold cognition among population of different ages and education background. The older or the higher education status patients had a better cognition (P < 0.01). There exist a certain degree of wrong cognition towards common cold among patients of different literacy degree and different age. Public health education on common cold need to be further strengthened.
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Glozah, Franklin N; Pevalin, David J
2017-09-01
Little is known about the role of age and gender in the association between psychosomatic symptoms and common mental illness in Ghanaian adolescents. This cross-sectional study examined age and gender as moderators between psychosomatic symptoms and common mental illness using data from a school-based survey ( N = 770). Males reported higher psychosomatic symptoms and common mental illness, while younger adolescents reported higher common mental illness only. Psychosomatic symptoms were positively associated with common mental illness, but age and gender did not moderate this association. Interventions aimed at reducing the prevalence rate in psychosomatic symptoms are crucial in decreasing common mental illness in Ghanaian adolescents.
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Code of Federal Regulations, 2010 CFR
2010-04-01
... 26 Internal Revenue 12 2010-04-01 2010-04-01 false Common parent agent for subsidiaries applicable... TAXES Regulations Applicable to Taxable Years Beginning Before June 28, 2002 § 1.1502-77A Common parent...) Scope of agency of common parent corporation. The common parent, for all purposes (other than the making...
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Something in Common: The Common Core Standards and the Next Chapter in American Education
ERIC Educational Resources Information Center
Rothman, Robert
2011-01-01
"Something in Common" is the first book to provide a detailed look at the groundbreaking Common Core State Standards and their potential to transform American education. This book tells the story of the unfolding political drama around the making of the Common Core State Standards for math and English language arts, which were adopted by…
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No Common Opinion on the Common Core
ERIC Educational Resources Information Center
Henderson, Michael B.; Peterson, Paul E.; West, Martin R.
2015-01-01
According to the three authors of this article, the 2014 "EdNext" poll yields four especially important new findings: (1) Opinion with respect to the Common Core has yet to coalesce. The idea of a common set of standards across the country has wide appeal, and the Common Core itself still commands the support of a majority of the public.…
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Turner, Leigh
2003-09-01
Many bioethicists assume that morality is in a state of wide reflective equilibrium. According to this model of moral deliberation, public policymaking can build upon a core common morality that is pretheoretical and provides a basis for practical reasoning. Proponents of the common morality approach to moral deliberation make three assumptions that deserve to be viewed with skepticism. First, they commonly assume that there is a universal, transhistorical common morality that can serve as a normative baseline for judging various actions and practices. Second, advocates of the common morality approach assume that the common morality is in a state of relatively stable, ordered, wide reflective equilibrium. Third, casuists, principlists, and other proponents of common morality approaches assume that the common morality can serve as a basis for the specification of particular policies and practical recommendations. These three claims fail to recognize the plural moral traditions that are found in multicultural, multiethnic, multifaith societies such as the United States and Canada. A more realistic recognition of multiple moral traditions in pluralist societies would be considerable more skeptical about the contributions that common morality approaches in bioethics can make to resolving contentious moral issues.
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2012-01-01
Background Common carp (Cyprinus carpio) is thought to have undergone one extra round of genome duplication compared to zebrafish. Transcriptome analysis has been used to study the existence and timing of genome duplication in species for which genome sequences are incomplete. Large-scale transcriptome data for the common carp genome should help reveal the timing of the additional duplication event. Results We have sequenced the transcriptome of common carp using 454 pyrosequencing. After assembling the 454 contigs and the published common carp sequences together, we obtained 49,669 contigs and identified genes using homology searches and an ab initio method. We identified 4,651 orthologous pairs between common carp and zebrafish and found 129,984 paralogous pairs within the common carp. An estimation of the synonymous substitution rate in the orthologous pairs indicated that common carp and zebrafish diverged 120 million years ago (MYA). We identified one round of genome duplication in common carp and estimated that it had occurred 5.6 to 11.3 MYA. In zebrafish, no genome duplication event after speciation was observed, suggesting that, compared to zebrafish, common carp had undergone an additional genome duplication event. We annotated the common carp contigs with Gene Ontology terms and KEGG pathways. Compared with zebrafish gene annotations, we found that a set of biological processes and pathways were enriched in common carp. Conclusions The assembled contigs helped us to estimate the time of the fourth-round of genome duplication in common carp. The resource that we have built as part of this study will help advance functional genomics and genome annotation studies in the future. PMID:22424280
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Hodges, Kevin E; Sulmasy, Daniel P
2013-09-01
The theory of principlism elaborated by Beauchamp and Childress in Principles of Biomedical Ethics has become extremely influential in bioethics. The theory employs the idea of the common morality as a foundation for the principles of autonomy, beneficence, nonmaleficence, and justice. According to this account, the content of the common morality is universal and constant, while variability in morals is due to the fact that the issue of who is included within the scope of moral status evolves over time. This suggests that issues of moral status are not part of the common morality at all, and this presents a conundrum: questions of moral status seem central to any substantive account of justice, and any conception of the common morality that excludes moral status therefore seems inadequate for supporting a robust principle of justice. We argue that proponents of common morality theory are left with four options: (1) making moral status a part of the objective common morality and ignoring evidence that views about moral status do seem to vary over time and place; (2) excluding justice from the substantive content of the common morality; (3) taking common morality to be an imperfect approximation of an independently justified and universal foundationalist ethic against which the common morality is judged; or (4) weakening claims about the universality of common morality, thereby allowing the common morality to support a variety of principles of justice applicable only within particular communities that have specified the scope of moral status. We suspect that proponents of common morality theory will not view any of these options favorably, which raises questions about the ultimate contribution of that account.
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Memory and Common Ground Processes in Language Use
Brown-Schmidt, Sarah; Duff, Melissa C.
2018-01-01
During communication, we form assumptions about what our communication partners know and believe. Information that is mutually known between the discourse partners—their common ground—serves as a backdrop for successful communication. Here we present an introduction to the focus of this topic, which is the role of memory in common ground and language use. Two types of questions emerge as central to understanding the relationship between memory and common ground, specifically questions having to do with the representation of common ground in memory, and the use of common ground during language processing. PMID:27797165
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Characterization of a Common-Gate Amplifier Using Ferroelectric Transistors
NASA Technical Reports Server (NTRS)
Hunt, Mitchell; Sayyah, Rana; MacLeod, Todd C.; Ho, Fat D.
2011-01-01
In this paper, the empirical data collected through experiments performed using a FeFET in the common-gate amplifier circuit is presented. The FeFET common-gate amplifier was characterized by varying all parameters in the circuit, such as load resistance, biasing of the transistor, and input voltages. Due to the polarization of the ferroelectric layer, the particular behavior of the FeFET common-gate amplifier presents interesting results. Furthermore, the differences between a FeFET common-gate amplifier and a MOSFET common-gate amplifier are examined.
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McMahon, Patrick
2017-01-01
Skin changes are common in children. Common concerns are birthmarks (e.g., hemangiomas and port wine stains), atopic and contact dermatitis, acne, and alopecia areata. The authors review advances in common and not so common skin changes in pediatric patients. PMID:28360970
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Enhanced definition and required examples of common datum imposed by ISO standard
NASA Astrophysics Data System (ADS)
Yan, Yiqing; Bohn, Martin
2017-12-01
According to the ISO Geometrical Product Specifications (GPS), the establishment and definition of common datum for geometrical components are not fully defined. There are two main limitations of this standard. Firstly: the explications of ISO examples of common datums are not matched with their corresponding definitions, and secondly: a full definition of common datum is missing. This paper suggests a new approach for an enhanced definition and concrete examples of common datum and proposes a holistic methodology for establishment of common datum for each geometrical component. This research is based on the analysis of physical behaviour of geometrical components, orientation constraints and invariance classes of datums. This approach fills the definition gaps of common datum based on ISO GPS, thereby eliminating those deficits. As a result, an improved methodology for a fully functional defined definition of common datum was formulated.
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Expert system development for commonality analysis in space programs
NASA Technical Reports Server (NTRS)
Yeager, Dorian P.
1987-01-01
This report is a combination of foundational mathematics and software design. A mathematical model of the Commonality Analysis problem was developed and some important properties discovered. The complexity of the problem is described herein and techniques, both deterministic and heuristic, for reducing that complexity are presented. Weaknesses are pointed out in the existing software (System Commonality Analysis Tool) and several improvements are recommended. It is recommended that: (1) an expert system for guiding the design of new databases be developed; (2) a distributed knowledge base be created and maintained for the purpose of encoding the commonality relationships between design items in commonality databases; (3) a software module be produced which automatically generates commonality alternative sets from commonality databases using the knowledge associated with those databases; and (4) a more complete commonality analysis module be written which is capable of generating any type of feasible solution.
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NASA Technical Reports Server (NTRS)
Creighton, Tom; Dragush, George; Hendrich, Louis; Hensley, Doug; Morgan, Louise; Oxendine, Charles; Remen, John; Robinson, Terry; Russell, Mark; Swift, Jerry
1987-01-01
The feasibility of commonality objectives are determined. Commonality is discussed in terms of weight penalties that increase the take-off weight of several members of the family of airplanes. Preliminary designs of fuselage structural members and a discussion of weight penalties due to implementation of common fuselage structure throughout the family is examined. Wing torque box designs are discussed along with structural weight penalties incurred. A landing gear design study is contained along with the weight penalties that a common gear system will impose. Implementation of common power plants throughout the family and the weight penalties that occur are discussed. The weight penalties imposed by commonality on all the airplanes in the family are summarized. Class 2 breakdowns are also presented. The feasibility of commonality based on a percentage of take-off weight increase over the Class 2 baseline weights is then assessed.
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USDA-ARS?s Scientific Manuscript database
Bean golden yellow mosaic virus (BGYMV) is an important disease of common bean (Phaseolus vulgaris L.) in Central America and the Caribbean. Bean common mosaic virus (BCMV) and bean common mosaic necrosis virus (BCMNV) pose a threat to common bean production throughout the world. The development an...
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How Common is Common Use Facilities at Airports
NASA Astrophysics Data System (ADS)
Barbeau, Addison D.
This study looked at common use airports across the country and at the implementation of common use facailities at airports. Common use consists of several elements that maybe installed at an airport. One of the elements is the self-service kiosks that allow passengers to have a faster check-in process, therefore moving them more quickly within the airport. Another element is signage and the incorporation of each airline's logo. Another aspect of common useis an airport regaining control of terminal gates by reducing the number of gates that are exclusively leased to a specific air carrier. This research focused on the current state of the common use facilities across the United States and examines the advantages and disadvantages of this approach. The research entailed interviews with personnel at a wide range of airports and found that each airport is in a different stage of implementation; some have fully implemented the common use concept while others are in the beginning stages of implementation. The questions were tailored to determine what the advantages and disadvantages are of a common use facility. The most common advantages reported included flexibility and cost. In the commom use system the airport reserves the right to move any airline to a different gate at any time for any reason. In turn, this helps reduce gates delays at that facility. For the airports that were interviewed no major disadvantages were reported. One down side of common use facilities for the airport involved is the major capital cost that is required to move to a common use system.
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A methodology for commonality analysis, with applications to selected space station systems
NASA Technical Reports Server (NTRS)
Thomas, Lawrence Dale
1989-01-01
The application of commonality in a system represents an attempt to reduce costs by reducing the number of unique components. A formal method for conducting commonality analysis has not been established. In this dissertation, commonality analysis is characterized as a partitioning problem. The cost impacts of commonality are quantified in an objective function, and the solution is that partition which minimizes this objective function. Clustering techniques are used to approximate a solution, and sufficient conditions are developed which can be used to verify the optimality of the solution. This method for commonality analysis is general in scope. It may be applied to the various types of commonality analysis required in the conceptual, preliminary, and detail design phases of the system development cycle.
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The structure of common-envelope remnants
NASA Astrophysics Data System (ADS)
Hall, Philip D.
2015-05-01
We investigate the structure and evolution of the remnants of common-envelope evolution in binary star systems. In a common-envelope phase, two stars become engulfed in a gaseous envelope and, under the influence of drag forces, spiral to smaller separations. They may merge to form a single star or the envelope may be ejected to leave the stars in a shorter period orbit. This process explains the short orbital periods of many observed binary systems, such as cataclysmic variables and low-mass X-ray binary systems. Despite the importance of these systems, and of common-envelope evolution to their formation, it remains poorly understood. Specifically, we are unable to confidently predict the outcome of a common-envelope phase from the properties at its onset. After presenting a review of work on stellar evolution, binary systems, common-envelope evolution and the computer programs used, we describe the results of three computational projects on common-envelope evolution. Our work specifically relates to the methods and prescriptions which are used for predicting the outcome. We use the Cambridge stellar-evolution code STARS to produce detailed models of the structure and evolution of remnants of common-envelope evolution. We compare different assumptions about the uncertain end-of-common envelope structure and envelope mass of remnants which successfully eject their common envelopes. In the first project, we use detailed remnant models to investigate whether planetary nebulae are predicted after common-envelope phases initiated by low-mass red giants. We focus on the requirement that a remnant evolves rapidly enough to photoionize the nebula and compare the predictions for different ideas about the structure at the end of a common-envelope phase. We find that planetary nebulae are possible for some prescriptions for the end-of-common envelope structure. In our second contribution, we compute a large set of single-star models and fit new formulae to the core radii of evolved stars. These formulae can be used to better compute the outcome of common-envelope evolution with rapid evolution codes. We find that the new formulae are necessary for accurate predictions of the properties of post-common envelope systems. Finally, we use detailed remnant models of massive stars to investigate whether hydrogen may be retained after a common-envelope phase to the point of core-collapse and so be observable in supernovae. We find that this is possible and thus common-envelope evolution may contribute to the formation of Type IIb supernovae.
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Memory and Common Ground Processes in Language Use.
Brown-Schmidt, Sarah; Duff, Melissa C
2016-10-01
During communication, we form assumptions about what our communication partners know and believe. Information that is mutually known between the discourse partners-their common ground-serves as a backdrop for successful communication. Here we present an introduction to the focus of this topic, which is the role of memory in common ground and language use. Two types of questions emerge as central to understanding the relationship between memory and common ground, specifically questions having to do with the representation of common ground in memory, and the use of common ground during language processing. Copyright © 2016 Cognitive Science Society, Inc.
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Experiment module concepts study. Volume 3: Module and subsystem design
NASA Technical Reports Server (NTRS)
Hunter, J. R.; Chiarappa, D. J.
1970-01-01
The final common module set exhibiting wide commonality is described. The set consists of three types of modules: one free flying module and two modules that operate attached to the space station. The common module designs provide for the experiment program as defined. The feasibility, economy, and practicality of these modules hinges on factors that do not affect the approach or results of the commonality process, but are important to the validity of the common module concepts. Implementation of the total experiment program requires thirteen common modules: five CM-1, five CM-3, and three CM-4 modules.
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Evolutionary evidence of the effect of rare variants on disease etiology.
Gorlov, I P; Gorlova, O Y; Frazier, M L; Spitz, M R; Amos, C I
2011-03-01
The common disease/common variant hypothesis has been popular for describing the genetic architecture of common human diseases for several years. According to the originally stated hypothesis, one or a few common genetic variants with a large effect size control the risk of common diseases. A growing body of evidence, however, suggests that rare single-nucleotide polymorphisms (SNPs), i.e. those with a minor allele frequency of less than 5%, are also an important component of the genetic architecture of common human diseases. In this study, we analyzed the relevance of rare SNPs to the risk of common diseases from an evolutionary perspective and found that rare SNPs are more likely than common SNPs to be functional and tend to have a stronger effect size than do common SNPs. This observation, and the fact that most of the SNPs in the human genome are rare, suggests that rare SNPs are a crucial element of the genetic architecture of common human diseases. We propose that the next generation of genomic studies should focus on analyzing rare SNPs. Further, targeting patients with a family history of the disease, an extreme phenotype, or early disease onset may facilitate the detection of risk-associated rare SNPs. © 2010 John Wiley & Sons A/S.
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Comprehensive analysis and discovery of drought-related NAC transcription factors in common bean.
Wu, Jing; Wang, Lanfen; Wang, Shumin
2016-09-07
Common bean (Phaseolus vulgaris L.) is an important warm-season food legume. Drought is the most important environmental stress factor affecting large areas of common bean via plant death or reduced global production. The NAM, ATAF1/2 and CUC2 (NAC) domain protein family are classic transcription factors (TFs) involved in a variety of abiotic stresses, particularly drought stress. However, the NAC TFs in common bean have not been characterized. In the present study, 86 putative NAC TF proteins were identified from the common bean genome database and located on 11 common bean chromosomes. The proteins were phylogenetically clustered into 8 distinct subfamilies. The gene structure and motif composition of common bean NACs were similar in each subfamily. These results suggest that NACs in the same subfamily may possess conserved functions. The expression patterns of common bean NAC genes were also characterized. The majority of NACs exhibited specific temporal and spatial expression patterns. We identified 22 drought-related NAC TFs based on transcriptome data for drought-tolerant and drought-sensitive genotypes. Quantitative real-time PCR (qRT-PCR) was performed to confirm the expression patterns of the 20 drought-related NAC genes. Based on the common bean genome sequence, we analyzed the structural characteristics, genome distribution, and expression profiles of NAC gene family members and analyzed drought-responsive NAC genes. Our results provide useful information for the functional characterization of common bean NAC genes and rich resources and opportunities for understanding common bean drought stress tolerance mechanisms.
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ERIC Educational Resources Information Center
Brett, William J.
1998-01-01
Discusses Boyer's proposal to incorporate the seven human commonalities into college courses so that students will become less parochial and more global individuals. Describes the application of this commonalities approach to both a general education course and an introductory course for biology majors. Commonalities are presented in a…
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47 CFR 63.22 - Facilities-based international common carriers.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 47 Telecommunication 3 2011-10-01 2011-10-01 false Facilities-based international common carriers. 63.22 Section 63.22 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER... Supplements § 63.22 Facilities-based international common carriers. The following conditions apply to...
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47 CFR 63.22 - Facilities-based international common carriers.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 47 Telecommunication 3 2012-10-01 2012-10-01 false Facilities-based international common carriers. 63.22 Section 63.22 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER... Supplements § 63.22 Facilities-based international common carriers. The following conditions apply to...
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47 CFR 63.22 - Facilities-based international common carriers.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 47 Telecommunication 3 2010-10-01 2010-10-01 false Facilities-based international common carriers. 63.22 Section 63.22 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER... Supplements § 63.22 Facilities-based international common carriers. The following conditions apply to...
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Vulvovaginitis- presentation of more common problems in pediatric and adolescent gynecology.
Loveless, Meredith; Myint, Ohmar
2018-04-01
Vulvovaginitis is one of the most common gynecological complaints presenting in the pediatric and adolescent female. The common causes of vulvovaginitis in the pediatric patient differ than that considered in adolescent females. When a child present with vulvar itching, burning and irritation the most common etiology is non-specific and hygiene measures are recommended. However these symptoms can mimic more serious etiologies including infection, labial adhesion, lichen sclerosis, pinworms and foreign body must be considered. Yeast infection is rare in the pediatric population but common in the adolescent. In the adolescent patient infections are more common. Yeast and bacterial vaginosis are commonly seen but due to the higher rate of sexual activity in this population sexually transmitted infections must also be considered. Copyright © 2017 Elsevier Ltd. All rights reserved.
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Targeted Upregulation of FMRP Expression as an Approach to the Treatment of Fragile X Syndrome
2016-10-01
Fragile X syndrome (FXS), the most common heritable form of intellectual disability and most common single-gene form of autism , is caused by partial...15. SUBJECT TERMS Fragile X, autism , FMR1, FXTAS, CGG repeat, epilepsy, seizures, FMRP, PTSD, premutation, iPSC, progenitor, calcium regulation...the most common heritable form of intellectual disability, the most common single-gene form of autism , and a relatively common cause of epilepsy
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40 CFR 81.167 - Southeast Desert Intrastate Air Quality Control Region.
Code of Federal Regulations, 2011 CFR
2011-07-01
... township line common to T. 32 S. and T. 31 S.; then north along the range line common to R. 35 E. and R. 34 E.; then east along the township line common to T. 29 S. and T. 28 S.; then north along the range line common to R. 36 E. and R. 35 E.; then east along the township line common to T. 28 S. and T. 27 S...
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40 CFR 81.167 - Southeast Desert Intrastate Air Quality Control Region.
Code of Federal Regulations, 2010 CFR
2010-07-01
... township line common to T. 32 S. and T. 31 S.; then north along the range line common to R. 35 E. and R. 34 E.; then east along the township line common to T. 29 S. and T. 28 S.; then north along the range line common to R. 36 E. and R. 35 E.; then east along the township line common to T. 28 S. and T. 27 S...
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Su, Nan; Lin, Jiang-tao; Liu, Guan-jian; Lin, Yan-ping; Yin, Kai-sheng; Bai, Chun-xue; Ma, Li-jun; Qiu, Chen; Liu, Chun-tao; Chen, Ming-wei; Liu, Hua; Chen, Ping
2012-04-01
To investigate the cognition of the common cold and current situation of the treatment among physicians from various levels of hospitals in Chinese mainland, so as to provide evidence for future continuing medical education and rational medication. A questionnaire designed for this survey was used to learn about the general information, cognitive degree of the common cold and prescription habits of physician who prescribed for cold within last three months, from various levels hospitals. A total of 1001 physicians were interviewed. Among them, 749 physicians chose right options that the cold was the common cold and the influenza with 79.84% in resident physicians and 56.76% in chief physicians. A total of 745 physicians chose options that the course of common cold will be lasting 4 to 7 days; 895 physicians chose options that old people are the most susceptible for complication; 669 physicians thought the common cold was the most common infection in winter; 841 physicians used clinical methods to diagnose the common cold; 736 physicians thought although the cold was a kind of self-limited disease and symptomatic treatment could alleviate symptoms and improve life quality, patients should see doctor in time if it turns to severer; and 745 physicians held the opinion that treatment of the common cold should focus on relieving symptoms first. In addition, 61.60% physicians had made prescription based on clinical symptoms; 505 (54.24%) of them thought compound drugs were priority in treating the common cold. However, there were still 43 physicians prescribed antibiotics for common cold. There is misunderstanding and discrepancy in cognition towards common cold and treatment among physicians from various levels of hospitals in mainland China. Physicians should standardize diagnosis and treatment for the common cold according to the domestic and foreign guidelines.
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Improving the value of clinical research through the use of Common Data Elements.
Sheehan, Jerry; Hirschfeld, Steven; Foster, Erin; Ghitza, Udi; Goetz, Kerry; Karpinski, Joanna; Lang, Lisa; Moser, Richard P; Odenkirchen, Joanne; Reeves, Dianne; Rubinstein, Yaffa; Werner, Ellen; Huerta, Michael
2016-12-01
The use of Common Data Elements can facilitate cross-study comparisons, data aggregation, and meta-analyses; simplify training and operations; improve overall efficiency; promote interoperability between different systems; and improve the quality of data collection. A Common Data Element is a combination of a precisely defined question (variable) paired with a specified set of responses to the question that is common to multiple datasets or used across different studies. Common Data Elements, especially when they conform to accepted standards, are identified by research communities from variable sets currently in use or are newly developed to address a designated data need. There are no formal international specifications governing the construction or use of Common Data Elements. Consequently, Common Data Elements tend to be made available by research communities on an empiric basis. Some limitations of Common Data Elements are that there may still be differences across studies in the interpretation and implementation of the Common Data Elements, variable validity in different populations, and inhibition by some existing research practices and the use of legacy data systems. Current National Institutes of Health efforts to support Common Data Element use are linked to the strengthening of National Institutes of Health Data Sharing policies and the investments in data repositories. Initiatives include cross-domain and domain-specific resources, construction of a Common Data Element Portal, and establishment of trans-National Institutes of Health working groups to address technical and implementation topics. The National Institutes of Health is seeking to lower the barriers to Common Data Element use through greater awareness and encourage the culture change necessary for their uptake and use. As National Institutes of Health, other agencies, professional societies, patient registries, and advocacy groups continue efforts to develop and promote the responsible use of Common Data Elements, particularly if linked to accepted data standards and terminologies, continued engagement with and feedback from the research community will remain important. © The Author(s) 2016.
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Code of Federal Regulations, 2010 CFR
2010-01-01
... company that is related by common ownership or common corporate control with another company. (c...) Common ownership or common corporate control means a relationship between two companies under which: (1) One company has, with respect to the other company: (i) Ownership, control, or power to vote 25...
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40 CFR 413.10 - Applicability: Description of the electroplating of common metals subcategory.
Code of Federal Regulations, 2010 CFR
2010-07-01
... electroplating of common metals subcategory. 413.10 Section 413.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS ELECTROPLATING POINT SOURCE CATEGORY Electroplating of Common Metals Subcategory § 413.10 Applicability: Description of the electroplating of common...
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Canonical Commonality Analysis.
ERIC Educational Resources Information Center
Leister, K. Dawn
Commonality analysis is a method of partitioning variance that has advantages over more traditional "OVA" methods. Commonality analysis indicates the amount of explanatory power that is "unique" to a given predictor variable and the amount of explanatory power that is "common" to or shared with at least one predictor…
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Occurrence and characterization of Bean common mosaic virus strain NL1 in Iowa
USDA-ARS?s Scientific Manuscript database
Bean common mosaic virus (BCMV) and the related Bean common mosaic necrosis virus (BCMNV) are widely distributed across the United States infecting primarily common bean (Phaseolus vulgaris). Eight characterized pathotypes have been distinguished on host differential cultivars. To further characteri...
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76 FR 63561 - Common Carriers; Editorial Amendments
Federal Register 2010, 2011, 2012, 2013, 2014
2011-10-13
... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 64 [DA 11-1649] Common Carriers; Editorial...-Billing Requirements for Common Carriers, Order (Order), document DA 11-1649, adopted September 30, 2011... Fund for the 2011-12 Fund year and the contribution factor used to determine the amount common carriers...
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42 CFR 447.45 - Timely claims payment.
Code of Federal Regulations, 2011 CFR
2011-10-01
... common physical location; (2) The practitioners share common waiting areas, examining rooms, treatment... common physical location other than the direct furnishing of professional health care services by the... the use of the common physical location or related support services, on a basis related to amounts...
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Supportive treatment for children with the common cold.
Ballengee, Cortney R; Turner, Ronald B
2014-02-01
This review summarizes recent developments in the supportive treatment of common cold symptoms in children. Conventional common cold therapies are no longer recommended for use in young children because of safety concerns. There are no studies that convincingly demonstrate the efficacy of any therapy for treatment of common cold symptoms in children less than 6 years of age and it is unlikely studies that establish efficacy can be done. Recent studies report a significant effect of probiotics on the occurrence of common cold illnesses in children, and studies in animals provide a plausible mechanism of action. These data suggest that the use of probiotics may have promise for the prevention of common cold illnesses in children. The effect of treatment on the severity of common cold symptoms cannot be accurately assessed with current study designs. In the absence of convincing evidence of efficacy, treatment of young children with symptomatic therapies cannot be recommended. Preliminary data suggest a small, beneficial effect of probiotics for the prevention of common cold illness.
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Minie, Mark; Bowers, Stuart; Tarczy-Hornoch, Peter; Roberts, Edward; James, Rose A.; Rambo, Neil; Fuller, Sherrilynne
2006-01-01
Setting: The University of Washington Health Sciences Libraries and Information Center BioCommons serves the bioinformatics needs of researchers at the university and in the vibrant for-profit and not-for-profit biomedical research sector in the Washington area and region. Program Components: The BioCommons comprises services addressing internal University of Washington, not-for-profit, for-profit, and regional and global clientele. The BioCommons is maintained and administered by the BioResearcher Liaison Team. The BioCommons architecture provides a highly flexible structure for adapting to rapidly changing resources and needs. Evaluation Mechanisms: BioCommons uses Web-based pre- and post-course evaluations and periodic user surveys to assess service effectiveness. Recent surveys indicate substantial usage of BioCommons services and a high level of effectiveness and user satisfaction. Next Steps/Future Directions: BioCommons is developing novel collaborative Web resources to distribute bioinformatics tools and is experimenting with Web-based competency training in bioinformation resource use. PMID:16888667
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Guelrud, M; Mendoza, S; Vicent, S; Gomez, M; Villalta, B
1983-02-01
To determine the significance of manometric pressure, measurements of the sphincter of Oddi in a control group and in patients with cholelithiasis with common duct stones with and without recurrent pancreatitis were studied. Sphincter of Oddi pressure was recorded continuously and by station pull-through by a triple lumen catheter. The basal sphincter of Oddi pressure, the mean pressure gradient between common duct and duodenum, and the sphincter of Oddi wave amplitude were measured. There was no significant difference between control subjects and patients with gallstones and common duct stones. In patients with common duct stones and recurrent pancreatitis the basal sphincter of Oddi pressure, the pressure gradient between common duct and duodenum, and the wave amplitude were significantly increased over control patients. These studies suggest that abnormalities in the sphincter of Oddi motor function are more common in patients with common duct stones with recurrent pancreatitis than in similar patients without pancreatitis.
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The opportunities for and challenges of common integrated electronics
NASA Astrophysics Data System (ADS)
Nelson, J. R.; Retterer, Bernard L.; Cloud, Harley A.
1994-02-01
This document summarizes a portion of IDA's work concerning common integrated electronics and the potential cost savings of using common electronic hardware and software. It addresses trends in avionics costs and recent experiences in applying common electronic standards to weapon programs as a way to reduce costs. The following essential elements of a program to acquire common integrated electronics are explored: (1) integrated system architecture; (2) advanced technology programs; (3) open system standards; (4) standard common modules; and (5) associated management and policies. The principal recommendation is that OSD support and coordinate such a-program by taking a strong leadership role and setting standards policy.
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An Annotated List of Tick (Acari: Ixodida) Common Names Authored by Harry Hoogstraal (1917-1986)
2011-01-01
to the comparatively recent rules promulgated by the American Arachnological Society Committee on Common Names of Arachnids (2003), most of... Arachnological Society Committee on Common Names of Arachnids (2003) Common Names of Arachnids, Fifth Edition. American Tarantula Society, accessible online
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47 CFR 69.608 - Carrier Common Line hypothetical net balance.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 47 Telecommunication 3 2010-10-01 2010-10-01 false Carrier Common Line hypothetical net balance. 69.608 Section 69.608 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER... net balance. The hypothetical net balance shall be equal to a Carrier Common Line revenue requirement...
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47 CFR 69.608 - Carrier Common Line hypothetical net balance.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 47 Telecommunication 3 2011-10-01 2011-10-01 false Carrier Common Line hypothetical net balance. 69.608 Section 69.608 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER... net balance. The hypothetical net balance shall be equal to a Carrier Common Line revenue requirement...
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49 CFR 1185.5 - Common control.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 49 Transportation 8 2014-10-01 2014-10-01 false Common control. 1185.5 Section 1185.5... OF TRANSPORTATION RULES OF PRACTICE INTERLOCKING OFFICERS § 1185.5 Common control. It shall not be... carriers if such carriers are operated under common control or management either: (a) Pursuant to approval...
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49 CFR 1185.5 - Common control.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 49 Transportation 8 2013-10-01 2013-10-01 false Common control. 1185.5 Section 1185.5... OF TRANSPORTATION RULES OF PRACTICE INTERLOCKING OFFICERS § 1185.5 Common control. It shall not be... carriers if such carriers are operated under common control or management either: (a) Pursuant to approval...
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49 CFR 1185.5 - Common control.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 49 Transportation 8 2010-10-01 2010-10-01 false Common control. 1185.5 Section 1185.5... OF TRANSPORTATION RULES OF PRACTICE INTERLOCKING OFFICERS § 1185.5 Common control. It shall not be... carriers if such carriers are operated under common control or management either: (a) Pursuant to approval...
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49 CFR 1185.5 - Common control.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 49 Transportation 8 2012-10-01 2012-10-01 false Common control. 1185.5 Section 1185.5... OF TRANSPORTATION RULES OF PRACTICE INTERLOCKING OFFICERS § 1185.5 Common control. It shall not be... carriers if such carriers are operated under common control or management either: (a) Pursuant to approval...
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Common Badging and Access Control System (CBACS)
NASA Technical Reports Server (NTRS)
Dischinger, Portia
2005-01-01
This slide presentation presents NASA's Common Badging and Access Control System. NASA began a Smart Card implementation in January 2004. Following site surveys, it was determined that NASA's badging and access control systems required upgrades to common infrastructure in order to provide flexibly, usability, and return on investment prior to a smart card implantation. Common Badging and Access Control System (CBACS) provides the common infrastructure from which FIPS-201 compliant processes, systems, and credentials can be developed and used.
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Sanchez-Donoso, Ines; Vilà, Carles; Puigcerver, Manel; Butkauskas, Dalius; Caballero de la Calle, José Ramón; Morales-Rodríguez, Pablo Antonio; Rodríguez-Teijeiro, José Domingo
2012-01-01
The common quail (Coturnix coturnix) is a popular game species for which restocking with farm-reared individuals is a common practice. In some areas, the number of released quails greatly surpasses the number of wild breeding common quail. However, common quail are difficult to raise in captivity and this casts suspicion about a possible hybrid origin of the farmed individuals from crosses with domestic Japanese quail (C. japonica). In this study we used a panel of autosomal microsatellite markers to characterize the genetic origin of quails reared for hunting purposes in game farms in Spain and of quails from an experimental game farm which was founded with hybrids that have been systematically backcrossed with wild common quails. The genotypes of these quail were compared to those of wild common quail and domestic strains of Japanese quail. Our results show that more than 85% of the game farm birds were not common quail but had domestic Japanese quail ancestry. In the experimental farm a larger proportion of individuals could not be clearly separated from pure common quails. We conclude that the majority of quail sold for restocking purposes were not common quail. Genetic monitoring of individuals raised for restocking is indispensable as the massive release of farm-reared hybrids could represent a severe threat for the long term survival of the native species. PMID:22701745
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Effect of Pleurotus eryngii Mushroom β-Glucan on Quality Characteristics of Common Wheat Pasta.
Kim, SunHee; Lee, Jo-Won; Heo, Yena; Moon, BoKyung
2016-04-01
The objective of this study was to evaluate the effect of β-glucan-rich fractions (BGRFs) from Pleurotus eryngii mushroom powder on the quality, textural properties, and sensory evaluation of common wheat pasta. Pasta was prepared from semolina flour and common wheat flour by replacing common wheat flour at 2%, 4%, and 6% with BGRFs. Semolina flour showed significantly higher viscosities than common wheat flour samples. However, all viscosities, except the breakdown viscosity, were reduced with increasing percentages of BGRFs. Replacement of the common wheat flour with BGRFs resulted in a reddish brown colored pasta with a lower L* value and a higher a* value. The common wheat pastas containing up to 4% BGRFs were not significantly different from semolina pasta with regard to cooking loss. Addition of up to 2% BGRFs had no significant impact on swelling index and water absorption. The addition of BGRFs in common wheat flour had a positive effect on the quality of common wheat pasta and resulted in hardness values similar to those of semolina pasta. In a sensory evaluation, cooked pasta with 2% BGRFs had the highest overall acceptability score. In summary, the results showed that common wheat flour containing 4% BGRFs could be used to produce pasta with an improved quality and texture properties similar to semolina pasta. © 2016 Institute of Food Technologists®
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Prenatal exposure to ambient temperature variation increases the risk of common cold in children.
Lu, Chan; Miao, Yufeng; Zeng, Ji; Jiang, Wei; Shen, Yong-Ming; Deng, Qihong
2018-06-15
Common cold is a frequent upper respiratory tract infection, but the role of ambient temperature in the infection is unclear. We investigated the role of prenatal exposure to diurnal temperature variation (DTV), the difference between the daily maximal and minimal temperatures, in the risk of common cold in children. We conducted a cohort study of 2598 preschool children in Changsha, China. Occurrence of common cold during the past year was surveyed using questionnaire. We then estimated each child's prenatal exposure to DTV during pregnancy. Multivariate logistic regression model was used to examine the association between occurrence of common cold and prenatal exposure to DTV in terms of odds ratios (OR) and 95% confidence interval (CI). About 45% children have common cold (≥3 times) during the past year. We found that common cold in children was associated with maternal DTV exposure during pregnancy, particularly during the first trimester with adjusted OR (95% CI) = 1.27 (1.10-1.46). Male and atopic children were more susceptible to the effect of DTV during pregnancy. The risk of common cold due to DTV is higher in children living in the suburban areas and the bigger houses and in those exposed to environmental tobacco smoke, mold/dampness, new furniture and redecoration. We observed that the risk of common cold in children has been increased in recent years due to increasing DTV. Common cold in children was associated with maternal exposure to temperature variation during pregnancy, suggesting that the risk of common cold may originate in pregnancy. Copyright © 2018 Elsevier Inc. All rights reserved.
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Some Chinese folk prescriptions for wind-cold type common cold.
Hai-Long, Zhai; Shimin, Chen; Yalan, Lu
2015-07-01
Although self-limiting, the common cold (gǎn mào) is highly prevalent. There are no effective antivirals to cure the common cold and few effective measures to prevent it, However, for thousands years, Chinese people have treated the common cold with natural herbs, According to the traditional Chinese medicine (TCM) theory ( zhōng yī lǐ lùn), the common cold is considered as an exterior syndrome, which can be further divided into the wind-cold type ( fēng hán xíng), the wind-heat type ( fēng rè xíng), and the summer heat dampness type ( shǔ rè xíng). Since the most common type of common cold caught in winter and spring is the wind-cold type, the article introduced some Chinese folk prescriptions for the wind-cold type common cold with normal and weak physique, respectively. For thousands of years, Chinese folk prescriptions for the common cold, as complementary and alternative medicine (CAM; bǔ chōng yǔ tì dài yī xué), have been proven to be effective, convenient, cheap, and most importantly, safe. The Chinese folk prescriptions ( zhōng guó mín jiān chǔ fāng) for the wind-cold type common cold are quite suitable for general practitioners or patients with the wind-cold type common cold, to treat the disease. Of course, their pharmacological features and mechanisms of action need to be further studied.
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NASA Astrophysics Data System (ADS)
Garabito, German; Cruz, João Carlos Ribeiro; Oliva, Pedro Andrés Chira; Söllner, Walter
2017-01-01
The Common Reflection Surface stack is a robust method for simulating zero-offset and common-offset sections with high accuracy from multi-coverage seismic data. For simulating common-offset sections, the Common-Reflection-Surface stack method uses a hyperbolic traveltime approximation that depends on five kinematic parameters for each selected sample point of the common-offset section to be simulated. The main challenge of this method is to find a computationally efficient data-driven optimization strategy for accurately determining the five kinematic stacking parameters on which each sample of the stacked common-offset section depends. Several authors have applied multi-step strategies to obtain the optimal parameters by combining different pre-stack data configurations. Recently, other authors used one-step data-driven strategies based on a global optimization for estimating simultaneously the five parameters from multi-midpoint and multi-offset gathers. In order to increase the computational efficiency of the global optimization process, we use in this paper a reduced form of the Common-Reflection-Surface traveltime approximation that depends on only four parameters, the so-called Common Diffraction Surface traveltime approximation. By analyzing the convergence of both objective functions and the data enhancement effect after applying the two traveltime approximations to the Marmousi synthetic dataset and a real land dataset, we conclude that the Common-Diffraction-Surface approximation is more efficient within certain aperture limits and preserves at the same time a high image accuracy. The preserved image quality is also observed in a direct comparison after applying both approximations for simulating common-offset sections on noisy pre-stack data.
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The Neglected Role of Non-Profit Organizations in the Intellectual-Commons Environment
ERIC Educational Resources Information Center
Lee, Jyh-An
2009-01-01
Intellectual commons are intellectual resources, which anyone can use either without permission, or with permission granted in advance. Since intellectual commons are crucially important to creativity, innovation, and human development, the shrinkage of the intellectual-commons environment will be a profound loss for our cultural freedom.…
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Developing germplasm resources to identify the genetic basis of resistance to common scab in potato
USDA-ARS?s Scientific Manuscript database
Common scab, caused mainly by the soil-borne bacterium Streptomyces scabies, produces lesions on potato tubers, reducing tuber quality and profitability. Methods to manage common scab are often expensive, impractical, and can be ineffective. Therefore, creating cultivars that are resistant to common...
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47 CFR 73.57 - Remote reading antenna and common point ammeters.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 47 Telecommunication 4 2014-10-01 2014-10-01 false Remote reading antenna and common point... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.57 Remote reading antenna and common point ammeters. Remote reading antenna and common point ammeters may be used without further authority...
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47 CFR 73.57 - Remote reading antenna and common point ammeters.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 47 Telecommunication 4 2013-10-01 2013-10-01 false Remote reading antenna and common point... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.57 Remote reading antenna and common point ammeters. Remote reading antenna and common point ammeters may be used without further authority...
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47 CFR 73.57 - Remote reading antenna and common point ammeters.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 47 Telecommunication 4 2012-10-01 2012-10-01 false Remote reading antenna and common point... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.57 Remote reading antenna and common point ammeters. Remote reading antenna and common point ammeters may be used without further authority...
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47 CFR 73.57 - Remote reading antenna and common point ammeters.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 47 Telecommunication 4 2011-10-01 2011-10-01 false Remote reading antenna and common point... RADIO SERVICES RADIO BROADCAST SERVICES AM Broadcast Stations § 73.57 Remote reading antenna and common point ammeters. Remote reading antenna and common point ammeters may be used without further authority...
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47 CFR 27.66 - Discontinuance, reduction, or impairment of service.
Code of Federal Regulations, 2013 CFR
2013-10-01
... licensee, or a fixed common carrier operating on spectrum licensed to a Guard Band Manager, is... carrier licensee, or a fixed common carrier operating on spectrum licensed to a Guard Band Manager... fixed non-common carrier licensee, or a fixed non-common carrier operating on spectrum licensed to a...
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47 CFR 27.66 - Discontinuance, reduction, or impairment of service.
Code of Federal Regulations, 2014 CFR
2014-10-01
... licensee, or a fixed common carrier operating on spectrum licensed to a Guard Band Manager, is... carrier licensee, or a fixed common carrier operating on spectrum licensed to a Guard Band Manager... fixed non-common carrier licensee, or a fixed non-common carrier operating on spectrum licensed to a...
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47 CFR 27.66 - Discontinuance, reduction, or impairment of service.
Code of Federal Regulations, 2012 CFR
2012-10-01
... licensee, or a fixed common carrier operating on spectrum licensed to a Guard Band Manager, is... carrier licensee, or a fixed common carrier operating on spectrum licensed to a Guard Band Manager... fixed non-common carrier licensee, or a fixed non-common carrier operating on spectrum licensed to a...
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47 CFR 27.66 - Discontinuance, reduction, or impairment of service.
Code of Federal Regulations, 2011 CFR
2011-10-01
... licensee, or a fixed common carrier operating on spectrum licensed to a Guard Band Manager, is... carrier licensee, or a fixed common carrier operating on spectrum licensed to a Guard Band Manager... fixed non-common carrier licensee, or a fixed non-common carrier operating on spectrum licensed to a...
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21 CFR 801.62 - Declaration of net quantity of contents.
Code of Federal Regulations, 2011 CFR
2011-04-01
... paragraph (p) of this section. (c) The declaration may contain common or decimal fractions. A common... there exists a firmly established, general consumer usage and trade custom of employing different common fractions in the net quantity declaration of a particular commodity, they may be employed. A common fraction...
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77 FR 38344 - Medallion Financial Corp.; Notice of Application
Federal Register 2010, 2011, 2012, 2013, 2014
2012-06-27
... increasing the maximum number of shares of Applicant's common stock (``Common Stock'') available for issuance... Amended Director Plan. Under the Amended Director Plan, a maximum of 200,000 shares of Applicant's Common... shares of Applicant's Common Stock that may be issued to any one Eligible Director. The Amended Director...
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21 CFR 201.62 - Declaration of net quantity of contents.
Code of Federal Regulations, 2011 CFR
2011-04-01
... this section. (c) The declaration may contain common or decimal fractions. A common fraction shall be... firmly established, general consumer usage and trade custom of employing different common fractions in the net quantity declaration of a particular commodity, they may be employed. A common fraction shall...
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21 CFR 201.62 - Declaration of net quantity of contents.
Code of Federal Regulations, 2010 CFR
2010-04-01
... this section. (c) The declaration may contain common or decimal fractions. A common fraction shall be... firmly established, general consumer usage and trade custom of employing different common fractions in the net quantity declaration of a particular commodity, they may be employed. A common fraction shall...
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21 CFR 701.13 - Declaration of net quantity of contents.
Code of Federal Regulations, 2011 CFR
2011-04-01
... will give such information. (d) The declaration may contain common or decimal fractions. A common... there exists a firmly established, general consumer usage and trade custom of employing different common fractions in the net quantity declaration of a particular commodity they may be employed. A common fraction...
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75 FR 39443 - Implementation of OMB Guidance on Drug-Free Workplace Requirements
Federal Register 2010, 2011, 2012, 2013, 2014
2010-07-09
... (DOE) is removing its regulation implementing the Governmentwide common rule on drug-free workplace... drug legislation on November 18, 1988. Federal agencies issued an interim final common rule to... Governmentwide common rule on nonprocurement suspension and debarment. The agencies issued a final common rule...
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Common Core Implementation Decisions Made by Principals in Elementary Schools
ERIC Educational Resources Information Center
Norman, Alexis Cienfuegos
2016-01-01
The purpose of this study was to understand the decisions elementary principals have made during the Common Core State Standards reform. Specifically, (a) what decisions principals have made to support Common Core implementation, (b) what strategies elementary principals have employed to communicate with stakeholders about Common Core State…
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Greenhouse and Field Nursery Evaluation for Potato Common Scab Tolerance in a Tetraploid Population
USDA-ARS?s Scientific Manuscript database
Potato common scab (Streptomyces scabies (Thaxt.) Waksman & Henrici) is a major disease of potato (Solanum tuberosum L.), due to the unmarketability of affected tubers. For identification of the most common scab-tolerant material, and for developing molecular markers for common scab tolerance, more ...
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Changes to the Common Rule Regulations and Implications for Human Research
The regulations that govern research involving human subjects are known as the “Common Rule,” because they are shared in common by 18 federal departments and agencies that conduct and support such research. [The US FDA is not a signatory to the Common Rule.] These reg...
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Charles J. Gatchell; R. Edward Thomas; R. Edward Thomas
1997-01-01
Using a new computer grading program (UGRS), 1 and 2A Common lumber was sorted based on the percentage of board surface measure found in the maximum allowable number of grading cuttings. For 1 Common, 46.0 percent of 921 boards had percentages in the FAS range (83-1/3% and above). For 2A Common, 54.7 percent of 825 boards had percentages in the 1 Common range. When...
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Noncommuting local common causes for correlations violating the Clauser-Horne inequality
DOE Office of Scientific and Technical Information (OSTI.GOV)
Hofer-Szabo, Gabor; Vecsernyes, Peter
2012-12-15
In the paper, the EPR-Bohm scenario will be reproduced in an algebraic quantum field theoretical setting with locally finite degrees of freedom. It will be shown that for a set of spatially separated correlating events (projections) maximally violating the Clauser-Horne inequality there can be given a common causal explanation if commutativity is abandoned between the common cause and the correlating events. Moreover, the noncommuting common cause will be local and supported in the common past of the correlating events.
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NASA Technical Reports Server (NTRS)
Rieker, Lorra L.; Haraburda, Francis M.
1989-01-01
The National Aeronautics and Space Administration has adopted the policy to achieve the maximum practical level of commonality for the Space Station Freedom program in order to significantly reduce life cycle costs. Commonality means using identical or similar hardware/software for meeting common sets of functionally similar requirements. Information on how the concept of commonality is being implemented with respect to electric power system hardware for the Space Station Freedom and the U.S. Polar Platform is presented. Included is a historical account of the candidate common items which have the potential to serve the same power system functions on both Freedom and the Polar Platform.
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Predicting missing links in complex networks based on common neighbors and distance
Yang, Jinxuan; Zhang, Xiao-Dong
2016-01-01
The algorithms based on common neighbors metric to predict missing links in complex networks are very popular, but most of these algorithms do not account for missing links between nodes with no common neighbors. It is not accurate enough to reconstruct networks by using these methods in some cases especially when between nodes have less common neighbors. We proposed in this paper a new algorithm based on common neighbors and distance to improve accuracy of link prediction. Our proposed algorithm makes remarkable effect in predicting the missing links between nodes with no common neighbors and performs better than most existing currently used methods for a variety of real-world networks without increasing complexity. PMID:27905526
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Slaves, embryos, and nonhuman animals: moral status and the limitations of common morality theory.
Lindsay, Ronald A
2005-12-01
Common morality theory must confront apparent counterexamples from the history of morality, such as the widespread acceptance of slavery in prior eras, that suggest core norms have changed over time. A recent defense of common morality theory addresses this problem by drawing a distinction between the content of the norms of the common morality and the range of individuals to whom these norms apply. This distinction is successful in reconciling common morality theory with practices such as slavery, but only at the cost of underscoring the limits of common morality theory, in particular its inability to resolve disputes about the moral status of entities. Given that many controversies in bioethics center on the disputed status of various entities, such as embryos and nonhuman animals, this is an important limitation. Nonetheless, common morality theory still can be a useful resource in diminishing moral conflict on issues that do not involve disputes over moral status.
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Knowledge representation for commonality
NASA Technical Reports Server (NTRS)
Yeager, Dorian P.
1990-01-01
Domain-specific knowledge necessary for commonality analysis falls into two general classes: commonality constraints and costing information. Notations for encoding such knowledge should be powerful and flexible and should appeal to the domain expert. The notations employed by the Commonality Analysis Problem Solver (CAPS) analysis tool are described. Examples are given to illustrate the main concepts.
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Competence across Europe: Highest Common Factor or Lowest Common Denominator?
ERIC Educational Resources Information Center
Winterton, Jonathan
2009-01-01
Purpose: The purpose of this article is to explore diversity in competence models across Europe and consider the extent to which there is sufficient common ground for a common European approach to underpin the European Qualifications Framework. Design/methodology/approach: The paper uses a literature review and interviews with policy makers.…
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ERIC Educational Resources Information Center
Feinberg, Walter
2007-01-01
This essay addresses the question: given the flattening out of the cultural hierarchy that was the vestige of colonialism and nation-building, is there anything that might be uniquely common about the common school in this postmodern age? By "uniquely common" I do not mean those subjects that all schools might teach, such as reading or arithmetic.…
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Code of Federal Regulations, 2010 CFR
2010-10-01
... 47 Telecommunication 5 2010-10-01 2010-10-01 false Special showing for renewal of common carrier... COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Common Carrier Fixed Point-to-Point Microwave Service § 101.705 Special showing for renewal of common carrier station...
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20 CFR 222.13 - Common-law marriage relationship.
Code of Federal Regulations, 2011 CFR
2011-04-01
... FAMILY RELATIONSHIPS Relationship as Wife, Husband, or Widow(er) § 222.13 Common-law marriage relationship. Under the laws of some States, a common-law marriage is one which is not solemnized in a formal... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Common-law marriage relationship. 222.13...
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20 CFR 222.13 - Common-law marriage relationship.
Code of Federal Regulations, 2013 CFR
2013-04-01
... FAMILY RELATIONSHIPS Relationship as Wife, Husband, or Widow(er) § 222.13 Common-law marriage relationship. Under the laws of some States, a common-law marriage is one which is not solemnized in a formal... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Common-law marriage relationship. 222.13...
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20 CFR 222.13 - Common-law marriage relationship.
Code of Federal Regulations, 2012 CFR
2012-04-01
... FAMILY RELATIONSHIPS Relationship as Wife, Husband, or Widow(er) § 222.13 Common-law marriage relationship. Under the laws of some States, a common-law marriage is one which is not solemnized in a formal... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Common-law marriage relationship. 222.13...
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20 CFR 222.13 - Common-law marriage relationship.
Code of Federal Regulations, 2014 CFR
2014-04-01
... FAMILY RELATIONSHIPS Relationship as Wife, Husband, or Widow(er) § 222.13 Common-law marriage relationship. Under the laws of some States, a common-law marriage is one which is not solemnized in a formal... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Common-law marriage relationship. 222.13...
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Combined Common Person and Common Item Equating of Medical Science Examinations.
ERIC Educational Resources Information Center
Kelley, Paul R.
This equating study of the National Board of Medical Examiners Examinations was a combined common persons and common items equating, using the Rasch model. The 1,000-item test was administered to about 3,000 second-year medical students in seven equal-length subtests: anatomy, physiology, biochemistry, pathology, microbiology, pharmacology, and…
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ESPC Common Model Architecture
2014-09-30
1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. ESPC Common Model Architecture Earth System Modeling...Operational Prediction Capability (NUOPC) was established between NOAA and Navy to develop common software architecture for easy and efficient...development under a common model architecture and other software-related standards in this project. OBJECTIVES NUOPC proposes to accelerate
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26 CFR 1.414(c)-1 - Commonly controlled trades or businesses.
Code of Federal Regulations, 2013 CFR
2013-04-01
... 26 Internal Revenue 5 2013-04-01 2013-04-01 false Commonly controlled trades or businesses. 1.414.... § 1.414(c)-1 Commonly controlled trades or businesses. For purposes of applying the provisions of... 416 (relating to top-heavy plans), all employees of two or more trades or businesses under common...
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26 CFR 1.414(c)-1 - Commonly controlled trades or businesses.
Code of Federal Regulations, 2014 CFR
2014-04-01
... 26 Internal Revenue 5 2014-04-01 2014-04-01 false Commonly controlled trades or businesses. 1.414.... § 1.414(c)-1 Commonly controlled trades or businesses. For purposes of applying the provisions of... 416 (relating to top-heavy plans), all employees of two or more trades or businesses under common...
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Common Carrier Access to Cable Communications: Regulatory and Economic Issues.
ERIC Educational Resources Information Center
Kestenbaum, Lionel
The implications of cable television (CATV) common carrier access and economic and regulatory issues associated with it are examined in this paper. The first section provides a discussion of the feasibility and legal basis of common carrier access; the next section contrasts common carrier access with existing over-the-air television broadcasting…
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Simplifying the ELA Common Core; Demystifying Curriculum
ERIC Educational Resources Information Center
Schmoker, Mike; Jago, Carol
2013-01-01
The English Language Arts (ELA) Common Core State Standards ([CCSS], 2010) could have a transformational effect on American education. Though the process seems daunting, one can begin immediately integrating the essence of the ELA Common Core in every subject area. This article shows how one could implement the Common Core and create coherent,…
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Common Worlds: Reconceptualising Inclusion in Early Childhood Communities
ERIC Educational Resources Information Center
Taylor, Affrica; Giugni, Miriam
2012-01-01
"Common worlds" is a conceptual framework developed to reconceptualise inclusion in early childhood communities. Common worlds take account of children's relations with all the others in their worlds--including the more-than-human others. The ethics and politics of living together in these common worlds is the central concern of this article. The…
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-04-02
... Software Developers on the Technical Specifications for Common Formats for Patient Safety Data Collection... software developers can provide input on these technical specifications for the Common Formats Version 1.1... specifications, which provide direction to software developers that plan to implement the Common Formats...
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Campus and Community Connections: The Evolving IUPUI Common Theme Project
ERIC Educational Resources Information Center
Hanna, Kathleen A.
2013-01-01
In 2009, IUPUI launched the Common Theme Project, designed to "promote campus unity, conversation, and collaboration on timely issues that connect IUPUI to central Indiana and the world." This paper briefly discusses the evolution of the Common Theme Project, from its roots as a freshman common reader to the current campus focus on…
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29 CFR 4001.3 - Trades or businesses under common control; controlled groups.
Code of Federal Regulations, 2012 CFR
2012-07-01
... CORPORATION GENERAL TERMINOLOGY § 4001.3 Trades or businesses under common control; controlled groups. For... control with such person. (2) Persons are under common control if they are members of a “controlled group... 29 Labor 9 2012-07-01 2012-07-01 false Trades or businesses under common control; controlled...
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29 CFR 4001.3 - Trades or businesses under common control; controlled groups.
Code of Federal Regulations, 2010 CFR
2010-07-01
... CORPORATION GENERAL TERMINOLOGY § 4001.3 Trades or businesses under common control; controlled groups. For... control with such person. (2) Persons are under common control if they are members of a “controlled group... 29 Labor 9 2010-07-01 2010-07-01 false Trades or businesses under common control; controlled...
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29 CFR 4001.3 - Trades or businesses under common control; controlled groups.
Code of Federal Regulations, 2014 CFR
2014-07-01
... CORPORATION GENERAL TERMINOLOGY § 4001.3 Trades or businesses under common control; controlled groups. For... control with such person. (2) Persons are under common control if they are members of a “controlled group... 29 Labor 9 2014-07-01 2014-07-01 false Trades or businesses under common control; controlled...
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29 CFR 4001.3 - Trades or businesses under common control; controlled groups.
Code of Federal Regulations, 2013 CFR
2013-07-01
... CORPORATION GENERAL TERMINOLOGY § 4001.3 Trades or businesses under common control; controlled groups. For... control with such person. (2) Persons are under common control if they are members of a “controlled group... 29 Labor 9 2013-07-01 2013-07-01 false Trades or businesses under common control; controlled...
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29 CFR 4001.3 - Trades or businesses under common control; controlled groups.
Code of Federal Regulations, 2011 CFR
2011-07-01
... CORPORATION GENERAL TERMINOLOGY § 4001.3 Trades or businesses under common control; controlled groups. For... control with such person. (2) Persons are under common control if they are members of a “controlled group... 29 Labor 9 2011-07-01 2011-07-01 false Trades or businesses under common control; controlled...
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Hippophae rhamnoides L.: common seabuckthorn
Richard T. Busing; Paul E. Slabaugh
2008-01-01
Common seabuckthorn - Hippophae rhamnoides L. - is native to northwestern Europe through central Asia to the Altai Mountains, western and northern China, and the northern Himalayas. Of the 2 species in the genus, only common seabuckthorn is widely cultivated (Rehder 1940). A very hardy deciduous shrub or a small tree, common seabuckthorn is used primarily for...
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Common Core State Standards 101
ERIC Educational Resources Information Center
Rothman, Robert
2013-01-01
The Common Core State Standards (CCSS) represent the first time that nearly every state has set common expectations for what students should know and be able to do. In the past, each state set its own standards, and the results varied widely. And while states collectively developed these common standards, decisions about the curriculum and…
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Revitalization of the Shared Commons: Education for Sustainability and Marginalized Cultures
ERIC Educational Resources Information Center
Glasson, George E.
2010-01-01
Education for sustainability provides a vision for revitalizing the environmental commons while preserving cultural traditions and human rights. What happens if the environmental commons is shared by two politically disparate and conflicting cultures? As in many shared common lands, what happens if one culture is dominant and represents a more…
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-12-08
... removing its regulation implementing the Governmentwide common rule on drug-free workplace requirements for....) as a part of omnibus drug legislation. Federal agencies issued an interim final common rule to... Governmentwide common rule on nonprocurement suspension and debarment. The agencies issued a final common rule...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-09-13
... common pool vessels for FY 2011 due to overages of FY 2010 catch levels. This measure will help prevent.... SUPPLEMENTARY INFORMATION: FY 2011 Differential DAS Counting for Common Pool Vessels Based on preliminary FY 2010 common pool catch information available in February 2011, NMFS previously estimated that common...
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Code of Federal Regulations, 2010 CFR
2010-04-01
... dividends on the registrant's common equity and related stockholder matters. 229.201 Section 229.201... the registrant's common equity and related stockholder matters. (a) Market information. (1)(i) Identify the principal United States market or markets in which each class of the registrant's common...
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Code of Federal Regulations, 2011 CFR
2011-04-01
... dividends on the registrant's common equity and related stockholder matters. 229.201 Section 229.201... the registrant's common equity and related stockholder matters. (a) Market information. (1)(i) Identify the principal United States market or markets in which each class of the registrant's common...
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Norms of Descriptive Adjective Responses to Common Nouns.
ERIC Educational Resources Information Center
Robbins, Janet L.
This paper gives the results of a controlled experiment on word association. The purpose was to establish norms of commonality of primary descriptive adjective responses to common nouns. The stimuli consisted of 203 common nouns selected from 10 everyday topics of conversation, approximately 20 from each topic. There were 350 subjects, 50% male,…
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20 CFR 222.13 - Common-law marriage relationship.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Common-law marriage relationship. 222.13... FAMILY RELATIONSHIPS Relationship as Wife, Husband, or Widow(er) § 222.13 Common-law marriage relationship. Under the laws of some States, a common-law marriage is one which is not solemnized in a formal...
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Common Core: Teaching Optimum Topic Exploration (TOTE)
ERIC Educational Resources Information Center
Karge, Belinda Dunnick; Moore, Roxane Kushner
2015-01-01
The Common Core has become a household term and yet many educators do not understand what it means. This article explains the historical perspectives of the Common Core and gives guidance to teachers in application of Teaching Optimum Topic Exploration (TOTE) necessary for full implementation of the Common Core State Standards. An effective…
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Advocacy: Emphasizing the Uncommon about the Common Core State Standards
ERIC Educational Resources Information Center
Kaplan, Sandra N.
2014-01-01
The author describes key issues and uncommon concerns about the Common Core State Standards that fit within two categories: philosophical and pedagogical. Philosophically, Common Core State K-12 Standards should not be expected to be mastered at a specific grade level but based on developmental readiness. Pedagogically, Common Core State Standards…
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USDA-ARS?s Scientific Manuscript database
The modern cultivated common bean (Phaseolus vulgaris) has evolved from wild common beans distributed in Central America, Mexico and the Andean region of South America. It has been reported that wild common bean accessions have higher levels of protein content than the domesticated dry bean cultiva...
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Mental Representation of Fractions: It All Depends on Whether They Are Common or Uncommon.
Liu, Fuchang
2017-08-13
This study examined whether common and uncommon fractions are mentally represented differently and whether common ones are used in accessing the magnitudes of uncommon ones. In Experiments 1 and 2, college education majors, most of whom were female, Caucasian, and in their early 20s, made comparisons involving common and uncommon fractions. In Experiment 3, participants were presented with comparison tasks involving uncommon fractions and asked to describe the strategies which they used in making such comparisons. Analysis of reaction times and error rates support the hypothesis that for common fractions, it is their holistic real value, rather than their individual components, that gets represented. For uncommon fractions, the access of their magnitudes is a process of retrieving and using a known common one having a similar value. Such results suggest that the development of the cognizance of the magnitudes of fractions may be principally a matter of common ones only and that learners' handling of uncommon fractions may be greatly facilitated through instructions on matching them with common ones having a similar value.
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Clinicoepidemiological Study of Different Types of Warts
Gupta, Sanjeev; Sharma, Yugal K.
2016-01-01
Background. Warts are cutaneous and, sometimes, mucosal lesions caused by one of the several human papilloma viruses. Aim. Assessment of the clinicoepidemiological aspects of warts. Materials and Methods. One hundred consecutive patients of warts presenting to the department of our institution were assigned two broad locational groups: genital and nongenital warts, the latter subdivided into common, plane, palmoplantar, mosaic, and digitate/filiform. Results. Ninety had nongenital and 10 had genital warts in our study; common (42%), palmoplantar (20%), and plane (18%) were the common types of the nongenital warts. All the genital warts were acuminate. In the second decade, the commonest age group, encompassed all patients of mosaic, 40% of palmoplantar, and 20% of genital warts. Overall male (66%) preponderance xisted. All cases of filiform warts were males. Mosaic warts affected females more commonly. Students (32%), laborers (28%), and housewives (16%) were the usual occupations. Cosmetic concern (92%), pain (16%), and itching (15%) were the common complaints. All patients of genital warts sought treatment within 6 months. Conclusions. Common, palmoplantar, and plane warts were the common types of nongenital warts. Overall prevalence peaked during the second decade but one-third of the cases of plane warts occurred during the first. Extremities were the most common sites (66.7%); face was the next commonly (23%) involved. PMID:27047542
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NASA Astrophysics Data System (ADS)
Aruna, S. A.; Zhang, P.; Lin, F. Y.; Ding, S. Y.; Yao, X. X.
2000-04-01
Within the framework of the thermally activated process of the flux line or flux line bundles, and by time integration of the 1D equation of motion of the circulating current density icons/Journals/Common/vecJ" ALT="vecJ" ALIGN="TOP"/> (icons/Journals/Common/rho" ALT="rho" ALIGN="TOP"/> ,t ), which is suitable for thin superconducting films (R >>d ,icons/Journals/Common/le" ALT="le" ALIGN="TOP"/> icons/Journals/Common/lambda" ALT="lambda" ALIGN="TOP"/> ), we present numerical calculations of the current profiles, magnetization hysteresis loops and ac susceptibility icons/Journals/Common/chi" ALT="chi" ALIGN="TOP"/> n = icons/Journals/Common/chi" ALT="chi" ALIGN="TOP"/> ´n +iicons/Journals/Common/chi" ALT="chi" ALIGN="TOP"/> ´´n for n = 1, 3 and 5 of a thin disc immersed in an axial time-dependent external magnetic field Ba (t ) = Bdc +Bac cos(2icons/Journals/Common/pi" ALT="pi" ALIGN="TOP"/> icons/Journals/Common/nu" ALT="nu" ALIGN="TOP"/> t ). Our calculated results are compared with those of the critical state model (CSM) and found to prove the approximate validity of the CSM below the irreversibility field. The differences between our computed results and those of the CSM are also discussed.
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Embedding Open-domain Common-sense Knowledge from Text
Goodwin, Travis; Harabagiu, Sanda
2017-01-01
Our ability to understand language often relies on common-sense knowledge – background information the speaker can assume is known by the reader. Similarly, our comprehension of the language used in complex domains relies on access to domain-specific knowledge. Capturing common-sense and domain-specific knowledge can be achieved by taking advantage of recent advances in open information extraction (IE) techniques and, more importantly, of knowledge embeddings, which are multi-dimensional representations of concepts and relations. Building a knowledge graph for representing common-sense knowledge in which concepts discerned from noun phrases are cast as vertices and lexicalized relations are cast as edges leads to learning the embeddings of common-sense knowledge accounting for semantic compositionality as well as implied knowledge. Common-sense knowledge is acquired from a vast collection of blogs and books as well as from WordNet. Similarly, medical knowledge is learned from two large sets of electronic health records. The evaluation results of these two forms of knowledge are promising: the same knowledge acquisition methodology based on learning knowledge embeddings works well both for common-sense knowledge and for medical knowledge Interestingly, the common-sense knowledge that we have acquired was evaluated as being less neutral than than the medical knowledge, as it often reflected the opinion of the knowledge utterer. In addition, the acquired medical knowledge was evaluated as more plausible than the common-sense knowledge, reflecting the complexity of acquiring common-sense knowledge due to the pragmatics and economicity of language. PMID:28649676
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Kivimäki, Mika; Lawlor, Debbie A; Singh-Manoux, Archana; Batty, G David; Ferrie, Jane E; Shipley, Martin J; Nabi, Hermann; Sabia, Séverine; Marmot, Michael G; Jokela, Markus
2009-10-06
To examine potential reciprocal associations between common mental disorders and obesity, and to assess whether dose-response relations exist. Prospective cohort study with four measures of common mental disorders and obesity over 19 years (Whitehall II study). Civil service departments in London. 4363 adults (28% female, mean age 44 years at baseline). Common mental disorder defined as general health questionnaire "caseness;" overweight and obesity based on Word Health Organization definitions. In models adjusted for age, sex, and body mass index at baseline, odds ratios for obesity at the fourth screening were 1.33 (95% confidence interval 1.00 to 1.77), 1.64 (1.13 to 2.36), and 2.01 (1.21 to 3.34) for participants with common mental disorder at one, two, or three preceding screenings compared with people free from common mental disorder (P for trend<0.001). The corresponding mean differences in body mass index at the most recent screening were 0.20, 0.31, and 0.50 (P for trend<0.001). These associations remained after adjustment for baseline characteristics related to mental health and exclusion of participants who were obese at baseline. In addition, obesity predicted future risk of common mental disorder, again with evidence of a dose-response relation (P for trend=0.02, multivariable model). However, this association was lost when people with common mental disorder at baseline were excluded (P for trend=0.33). These findings suggest that in British adults the direction of association between common mental disorders and obesity is from common mental disorder to increased future risk of obesity. This association is cumulative such that people with chronic or repeat episodes of common mental disorder are particularly at risk of weight gain.
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Simulated population responses of common carp to commercial exploitation
DOE Office of Scientific and Technical Information (OSTI.GOV)
Weber, Michael J.; Hennen, Matthew J.; Brown, Michael L.
2011-12-01
Common carp Cyprinus carpio is a widespread invasive species that can become highly abundant and impose deleterious ecosystem effects. Thus, aquatic resource managers are interested in controlling common carp populations. Control of invasive common carp populations is difficult, due in part to the inherent uncertainty of how populations respond to exploitation. To understand how common carp populations respond to exploitation, we evaluated common carp population dynamics (recruitment, growth, and mortality) in three natural lakes in eastern South Dakota. Common carp exhibited similar population dynamics across these three systems that were characterized by consistent recruitment (ages 3 to 15 years present),more » fast growth (K = 0.37 to 0.59), and low mortality (A = 1 to 7%). We then modeled the effects of commercial exploitation on size structure, abundance, and egg production to determine its utility as a management tool to control populations. All three populations responded similarly to exploitation simulations with a 575-mm length restriction, representing commercial gear selectivity. Simulated common carp size structure modestly declined (9 to 37%) in all simulations. Abundance of common carp declined dramatically (28 to 56%) at low levels of exploitation (0 to 20%) but exploitation >40% had little additive effect and populations were only reduced by 49 to 79% despite high exploitation (>90%). Maximum lifetime egg production was reduced from 77 to 89% at a moderate level of exploitation (40%), indicating the potential for recruitment overfishing. Exploitation further reduced common carp size structure, abundance, and egg production when simulations were not size selective. Our results provide insights to how common carp populations may respond to exploitation. Although commercial exploitation may be able to partially control populations, an integrated removal approach that removes all sizes of common carp has a greater chance of controlling population abundance and reducing perturbations induced by this invasive species.« less
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Goodbred, Steven L.; Leiker, Thomas J.; Patiño, Reynaldo; Jenkins, Jill A.; Denslow, Nancy D.; Orsak, Erik; Rosen, Michael R.
2007-01-01
The U.S. Geological Survey, in cooperation with the U.S. Fish and Wildlife Service, National Park Service, Bureau of Reclamation, and Nevada Department of Wildlife, collected and assessed data to determine the general health and reproductive status of common carp (Cyprinus carpio) at two study areas in Lake Mead, Nevada, during May 1999-May 2000. These data will form the basis of interpretations and provide a comparison for continuing studies on the health of the ecosystem in Lake Mead. One study area, Las Vegas Bay, is in the western part of Lake Mead. Las Vegas Bay receives inflows from Las Vegas Wash, which is predominantly tertiary-treated wastewater effluent, and to a lesser extent stormwater runoff from Las Vegas, Henderson, and other nearby communities, and from ground water underlying Las Vegas Valley. The other study area, Overton Arm, is in the northern extent of Lake Mead. Overton Arm receives inflow from the Virgin and Muddy Rivers, which historically are not influenced by wastewater effluent. Both sexes of common carp were collected bimonthly for 12 months using boat-mounted electrofishing gear (a direct electric current is used to temporarily immobilize fish for capture) to determine their health and reproductive status and any relation between these factors and environmental contaminants. This report presents fish tissue chemistry, organic chemical compound concentrations, and biomarker data for 83 male common carp collected from Las Vegas Bay, similar organic chemistry results for 15 male common carp, and similar biomarker measures for 80 male common carp collected from Overton Arm. Tissue chemistry results also are presented for 16 female common carp and biomarker measures for 79 female common carp collected from Las Vegas Bay, and tissue chemistry results for 15 female common carp and biomarker measures for 81 female common carp collected from Overton Arm. Thirty-three organic chemical compounds plus total concentrations for four groups of compounds (chlordanes, polychlorinated biphenyls [PCBs], brominated diphenyl ethers [BDEs], and triclosans) were analyzed from extracts of whole-body tissue using gas chromatography/mass spectrometry in male common carp from Las Vegas Bay during May 1999 through May 2000. All 33 compounds were detected in at least one sample of whole-body tissue from male common carp collected in Las Vegas Bay. In Overton Arm, 37 organic compounds plus total concentrations of three groups of compounds (PCBs, BDEs, and triclosans) were analyzed in male common carp where 20 (54 percent) of the compounds were detected. Sixteen of the 33 compounds detected in male common carp from Las Vegas Bay and 10 compounds detected in males from Overton Arm have the potential to disrupt the endocrine system in fish in Lake Mead. During May and June 1999, the mean concentration of all organic compounds detected in male common carp was 670 micrograms per kilogram from Las Vegas Bay and 109 micrograms per kilogram from Overton Arm. Twenty-seven organic compounds plus total PCBs were analyzed from extracts of whole-body tissue in female common carp collected in Las Vegas Bay and Overton Arm during May 1999. Twenty-four (86 percent) of these compounds were detected in at least one sample of whole-body tissue from female common carp collected from Las Vegas Bay while 10 (36 percent) chemical compounds were detected in female common carp from Overton Arm during that same period. Median concentrations of all chemical compounds were higher in female common carp from Las Vegas Bay compared to those collected from Overton Arm except Dacthal (DCPA), which was similar between sites. Biomarker measures obtained for male and female common carp include gonadosomatic index (percentage of gonad weight to total body weight), plasma vitellogenin (a phospholipid protein normally produced by female common carp and other oviparous fish), and condition factor [body weight/(fork length)3]. Biomarker measures for male c
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Using a Linear Regression Method to Detect Outliers in IRT Common Item Equating
ERIC Educational Resources Information Center
He, Yong; Cui, Zhongmin; Fang, Yu; Chen, Hanwei
2013-01-01
Common test items play an important role in equating alternate test forms under the common item nonequivalent groups design. When the item response theory (IRT) method is applied in equating, inconsistent item parameter estimates among common items can lead to large bias in equated scores. It is prudent to evaluate inconsistency in parameter…
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2005-09-01
utilizing common household products that contain precursor chemicals which, when combined, become explosive. B. IMPORTANCE Improvised Explosive...legislation removing acetone or other common household products from the market. Consumer convenience is a powerful lobbying factor and law makers...as IEDs rather than common household products . 23 Oklahoma City National Memorial website, http
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47 CFR 69.152 - End user common line for price cap local exchange carriers.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 47 Telecommunication 3 2010-10-01 2010-10-01 false End user common line for price cap local...) COMMON CARRIER SERVICES (CONTINUED) ACCESS CHARGES Computation of Charges for Price Cap Local Exchange Carriers § 69.152 End user common line for price cap local exchange carriers. (a) A charge that is...
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Homage to Barry Commoner, a precursor of ecosocialism (May 28, 1917-September 30, 2012).
Tanuro, Daniel
2012-01-01
Barry Commoner died September 30, 2012, at the age of 95. Daniel Tanuro reviews Commoner's books to remind us of both his scientific and political contributions. Tanuro sees Commoner as a scientist and a Marxist whose research and writings as well as his role as a public spokesperson laid the foundations of ecosocialism.
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47 CFR 74.22 - Use of common antenna structure.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 47 Telecommunication 4 2010-10-01 2010-10-01 false Use of common antenna structure. 74.22 Section... Applicable to All Services in Part 74 § 74.22 Use of common antenna structure. The simultaneous use of a common antenna structure by more than one station authorized under this part, or by one or more stations...
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47 CFR 74.22 - Use of common antenna structure.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 47 Telecommunication 4 2012-10-01 2012-10-01 false Use of common antenna structure. 74.22 Section... Applicable to All Services in Part 74 § 74.22 Use of common antenna structure. The simultaneous use of a common antenna structure by more than one station authorized under this part, or by one or more stations...
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47 CFR 74.22 - Use of common antenna structure.
Code of Federal Regulations, 2014 CFR
2014-10-01
... 47 Telecommunication 4 2014-10-01 2014-10-01 false Use of common antenna structure. 74.22 Section... Applicable to All Services in Part 74 § 74.22 Use of common antenna structure. The simultaneous use of a common antenna structure by more than one station authorized under this part, or by one or more stations...
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47 CFR 74.22 - Use of common antenna structure.
Code of Federal Regulations, 2011 CFR
2011-10-01
... 47 Telecommunication 4 2011-10-01 2011-10-01 false Use of common antenna structure. 74.22 Section... Applicable to All Services in Part 74 § 74.22 Use of common antenna structure. The simultaneous use of a common antenna structure by more than one station authorized under this part, or by one or more stations...
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47 CFR 74.22 - Use of common antenna structure.
Code of Federal Regulations, 2013 CFR
2013-10-01
... 47 Telecommunication 4 2013-10-01 2013-10-01 false Use of common antenna structure. 74.22 Section... Applicable to All Services in Part 74 § 74.22 Use of common antenna structure. The simultaneous use of a common antenna structure by more than one station authorized under this part, or by one or more stations...
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Using Digital Video Production to Meet the Common Core Standards
ERIC Educational Resources Information Center
Nichols, Maura
2012-01-01
The implementation of the Common Core Standards has just begun and these standards will impact a generation that communicates with technology more than anything else. Texting, cell phones, Facebook, YouTube, Skype, etc. are the ways they speak with their friends and the world. The Common Core Standards recognize this. According to the Common Core…
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Commons Dilemma Choices in Small vs. Large Groups.
ERIC Educational Resources Information Center
Powers, Richard B.; Boyle, William
The purpose of the Commons Game is to teach students how social traps work; that is, that short-term individual gain tends to dominate long-term collective gain. Simulations of Commons Dilemma have grown considerably in the last decade; however, the research has used small face-to-face groups to study behavior in the Commons. To compare the…
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-15
... Management Plan and Sector Annual Catch Entitlements; Updated Annual Catch Limits for Sectors and the Common... (ACLs) for common pool vessels (common pool sub-ACLs), ACLs for sector vessels (sector sub-ACLs), and... number of participants electing to fish in either sectors or the common pool fishery in FY 2011. DATES...
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-06-30
...% of the preferred non-voting Interests (``Preferred Interests'') and 47.2% of the Common Interests,\\12\\ as Class A Common Interests. The Founding Firms will own the remaining 52.8% of the Common Interests, as Class B Common Interests, and no single Founding Firm (including its affiliates) will own Class B...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-09-10
... require that any overage of the GB yellowtail flounder TAC specified for the common pool, individual... deduction will be divided between the annual catch limit (ACL) for common pool vessels (common pool sub-ACL... that ``any overages of the GB cod and GB haddock TACs specified for either the common pool or...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-05-26
... Catch Entitlements: Updated Annual Catch Limits for Sectors and the Common Pool for Fishing Year 2010... fishing year (FY) 2010 specification of annual catch limits (ACLs) for common pool vessels (common pool... fish in the common pool for FY 2010. DATES: Effective May 21, 2010 through April 30, 2011. FOR FURTHER...
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Federal Register 2010, 2011, 2012, 2013, 2014
2010-08-11
... under common pool regulations for the 2010 fishing year (FY). This action also corrects a previously published cod trip limit for common pool vessels fishing under a limited access Handgear A permit. This... common pool (common pool sub-ACL) and underharvesting the sub-ACL for pollock during FY 2010 (May 1, 2010...
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Wetland Plants of the Pacific Northwest.
1984-09-01
69 Cares /yngbyei .............. 34 Lemna minor ............... 44 C obnupta ................. 34 Lilaeopsis..................26...programs have been established. Common associates include pond weeds, white water ily, and common duckweed. 45 40- II 5: * .- DEEP FRESHWATER MARSHES Lemna ... minor SCIENTIFIC NAME COMMON DUCKWEED COMMON NAME Field Characters: Individual plants are minute, consisting of a single leaf (called a "thallus") 2
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Code of Federal Regulations, 2010 CFR
2010-07-01
... accounting system do in relation to common carrier transportation? 301-72.100 Section 301-72.100 Public... for Common Carrier Transportation § 301-72.100 What must my travel accounting system do in relation to... claims accounting systems with common carrier transportation documents and data for audit purposes; (c...
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Beyond the Core: Peer Observation Brings Common Core to Vocational and Electives Classes
ERIC Educational Resources Information Center
Thurber Rasmussen, Harriette
2014-01-01
This article describes how a Washington State School District increased professional learning around the Common Core State Standards. The challenge was how to establish a way for career and technical education and electives teachers to learn and apply Common Core in their classes. Weaving Common Core literacy standards into vocational and…
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Revising the Common Rule: What is it, how did we get here, and where are we going?
The regulations that govern research involving human subjects are known as the “Common Rule,” because they are shared in common by 18 federal departments and agencies that conduct and support such research. [The US FDA is not a signatory to the Common Rule.] These reg...
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ERIC Educational Resources Information Center
Baines, Lawrence; Foster, Hal
2006-01-01
This article examines the history and the concept of the common school from the Common School Movement reformers of the 1850s to the present. These reformers envisioned schools that were to be tuition free and open to everyone, places where rich and poor met and learned together on equal terms. Central to the concept of the common school is its…
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26 CFR 1.58-5 - Common trust funds.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Common trust funds. 1.58-5 Section 1.58-5... Preference Regulations § 1.58-5 Common trust funds. Section 58(e) provides that each participant in a common trust fund (as defined in section 584 and the regulations thereunder) is to treat as items of tax...
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26 CFR 1.584-1 - Common trust funds.
Code of Federal Regulations, 2010 CFR
2010-04-01
... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Common trust funds. 1.584-1 Section 1.584-1...) INCOME TAXES (CONTINUED) Banking Institutions § 1.584-1 Common trust funds. (a) Method of taxation. A common trust fund maintained by a bank is not subject to taxation under this chapter and is not...
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The Use of Common Planning Time: A Case Study of Two Kentucky Schools to Watch
ERIC Educational Resources Information Center
Cook, Christopher M.; Faulkner, Shawn A.
2010-01-01
Interdisciplinary teams with common planning time have been a hallmark of the middle school organizational structure since the 1960s, yet research on the effective use of common planning time is limited. This study explores how interdisciplinary teams at schools designated Kentucky Schools to Watch use common planning time, including the factors…
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Complete genome sequences of two novel bipartite begomoviruses infecting common bean in Cuba.
Chang-Sidorchuk, Lidia; González-Alvarez, Heidy; Navas-Castillo, Jesús; Fiallo-Olivé, Elvira; Martínez-Zubiaur, Yamila
2017-05-01
The common bean is a host for a large number of begomoviruses (genus Begomovirus, family Geminiviridae) in the New World. Based on the current taxonomic criteria established for the genus Begomovirus, two new members of this genus infecting common bean (Phaseolus vulgaris) in Cuba are herein reported. The cloned bipartite genomes, composed of DNA-A and DNA-B, showed the typical organization of the New World begomoviruses. We propose the names common bean severe mosaic virus and common bean mottle virus for the new begomovirus species.
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The principle of commonality and its application to the Space Station Freedom Program
NASA Technical Reports Server (NTRS)
Hopson, George D.; Thomas, L. Dale; Daniel, Charles C.
1989-01-01
The principle of commonality has achieved wide application in the communication, automotive, and aircraft industries. By the use of commonality, component development costs are minimized, logistics are simplified, and the investment costs of spares inventory are reduced. With space systems, which must be maintained and repaired in orbit, the advantages of commonality are compounded. Transportation of spares is expensive, on-board storage volume for spares is limited, and crew training and special tools needed for maintenance and repair are significant considerations. This paper addresses the techniques being formulated to realize the benefits of commonality in the design of the systems and elements of the Space Station Freedom Program, and include the criteria for determining the extent of commonality to be implemented.
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A remark on the GNSS single difference model with common clock scheme for attitude determination
NASA Astrophysics Data System (ADS)
Chen, Wantong
2016-09-01
GNSS-based attitude determination technique is an important field of study, in which two schemes can be used to construct the actual system: the common clock scheme and the non-common clock scheme. Compared with the non-common clock scheme, the common clock scheme can strongly improve both the reliability and the accuracy. However, in order to gain these advantages, specific care must be taken in the implementation. The cares are thus discussed, based on the generating technique of carrier phase measurement in GNSS receivers. A qualitative assessment of potential phase bias contributes is also carried out. Possible technical difficulties are pointed out for the development of single-board multi-antenna GNSS attitude systems with a common clock.
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Domínguez-López, M E; González-molero, I; Ramírez-Plaza, C P; Soriguer, F; Olveira, G
2011-01-01
Gastric cancer is a frequent cause of cancer-related mortality in the world. Surgery is the only potentially curative therapy, although the adverse effects of surgery are common and considerable. Common variable immunodeficiency is in many cases cause of gastrointestinal system problems such as chronic diarrhea caused by infestation with giardia lamblia, nodular lymphoid hiperplasia ad loss of villi leading frequently to malapsortion and malnutrition. Nutritional deficiencies due to malapsorption (postgastrectomy and secondary to loss of villi, giardiasis and common variable inmunodeficiency) are common. We present the case of a patient with gastric cancer who underwent a gastrectomy with common variable hipogammaglobulinemia and chronic infestation by giardia lamblia, with serious diarrhea resistant to treatment and malabsorption.
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Total rupture of hydatid cyst of liver in to common bile duct: a case report.
Robleh, Hassan; Yassine, Fahmi; Driss, Khaiz; Khalid, Elhattabi; Fatima-Zahra, Bensardi; Saad, Berrada; Rachid, Lefriyekh; Abdalaziz, Fadil; Najib, Zerouali Ouariti
2014-01-01
Rupture of hydatid liver cyst into biliary tree is frequent complications that involve the common hepatic duct, lobar biliary branches, the small intrahepatic bile ducts,but rarely rupture into common bile duct. The rupture of hydatid cyst is serious life threating event. The authors are reporting a case of total rupture of hydatid cyst of liver into common bile duct. A 50-year-old male patient who presented with acute cholangitis was diagnosed as a case of totally rupture of hydatid cyst on Abdominal CT Scan. Rupture of hydatid cyst of liver into common bile duct and the gallbladder was confirmed on surgery. Treated by cholecystectomy and T-tube drainage of Common bile duct.
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Commonality of Ground Systems in Launch Operations
NASA Technical Reports Server (NTRS)
Quinn, Shawn M.
2008-01-01
NASA is examining the utility of requiring a certain degree of commonality in both flight and ground systems in the Constellation Program. While the benefits of commonality seem obvious in terms of minimizing upfront development and long-term operations and maintenance costs, success in real, large-scale engineering systems used to support launch operations is relatively unknown. A broad literature review conducted for this paper did not yield a single paper specifically addressing the application of commonality for ground systems at any launch site in the United States or abroad. This paper provides a broad overview of the ground systems, captures historical and current application of commonality at the launch site, and offers suggestions for additional research to further develop commonality approaches.
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Multivariate modelling of endophenotypes associated with the metabolic syndrome in Chinese twins.
Pang, Z; Zhang, D; Li, S; Duan, H; Hjelmborg, J; Kruse, T A; Kyvik, K O; Christensen, K; Tan, Q
2010-12-01
The common genetic and environmental effects on endophenotypes related to the metabolic syndrome have been investigated using bivariate and multivariate twin models. This paper extends the pairwise analysis approach by introducing independent and common pathway models to Chinese twin data. The aim was to explore the common genetic architecture in the development of these phenotypes in the Chinese population. Three multivariate models including the full saturated Cholesky decomposition model, the common factor independent pathway model and the common factor common pathway model were fitted to 695 pairs of Chinese twins representing six phenotypes including BMI, total cholesterol, total triacylglycerol, fasting glucose, HDL and LDL. Performances of the nested models were compared with that of the full Cholesky model. Cross-phenotype correlation coefficients gave clear indication of common genetic or environmental backgrounds in the phenotypes. Decomposition of phenotypic correlation by the Cholesky model revealed that the observed phenotypic correlation among lipid phenotypes had genetic and unique environmental backgrounds. Both pathway models suggest a common genetic architecture for lipid phenotypes, which is distinct from that of the non-lipid phenotypes. The declining performance with model restriction indicates biological heterogeneity in development among some of these phenotypes. Our multivariate analyses revealed common genetic and environmental backgrounds for the studied lipid phenotypes in Chinese twins. Model performance showed that physiologically distinct endophenotypes may follow different genetic regulations.
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Grov, Christian; Crow, Thomas
2018-01-01
This study examined attitudes toward the most common place where men who have sex with men (MSM) met their recent male sex partners. In 2009–2010, MSM were surveyed in bars/clubs, bathhouses, and on Craigslist.org. We found strong but differential overlap between venue of recruitment and participants’ most common place: 81% of men from Craigslist indicated their most common place was the Internet, 65% of men from bathhouses indicated their most common place was bathhouses, and 47% of men from bars/clubs indicated their most common place was bars/clubs. In general, interest in seeing more information on drugs/alcohol and HIV and interacting with a health outreach worker in participants’ most common place ranged from “agree” to “strongly agree.” However, men whose most common place was bars/clubs rated these items lowest on average. Rates of unprotected anal intercourse (UAI) were high (43%), thus targeted efforts in bars/clubs, bathhouses, and on the Internet may be ideal venues for reaching high-risk MSM. Although most common place was unrelated to UAI, it was related to factors that contextualize men’s encounters (e.g., attitudes toward HIV status disclosure, and perceptions about barebacking, anonymous sex, and alcohol use). Outreach providers should consider these contextualizing aspects as they continue to retool their efforts. PMID:22468972
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USDA-ARS?s Scientific Manuscript database
Common bacterial blight caused by the pathogen Xanthomonas axonopodis pv. phaseoli (Xap) is an important biotic factor limiting common bean (Phaseolus vulgaris L.) production. A few interspecific bean breeding lines such as VAX 6 exhibit a high level of resistance to a wide range of Xap strains repr...
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Common Core State Standards Alignment: Advanced Placement[R]. Research Report 2011-8
ERIC Educational Resources Information Center
Hart, Beth; Carman, Elaine; Luisier, Danielle; Vasavada, Natasha
2011-01-01
The College Board has been a strong advocate for and played an active role in the development of the Common Core State Standards. As part of this collaboration, the College Board helped draft the standards and helped shape the initiative by providing executive guidance on the Common Core Advisory Committee. The goal of the Common Core State…
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USDA-ARS?s Scientific Manuscript database
Common bean (Phaseolus vulgaris) and soybean (Glycine max) both belong to the Phaseoleae tribe and share significant coding sequence homology. To evaluate the utility of the soybean GeneChip for transcript profiling of common bean, we hybridized cRNAs purified from nodule, leaf, and root of common b...
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Virta, R.L.
1998-01-01
Part of a special section on the state of industrial minerals in 1997. The state of the common clay industry worldwide for 1997 is discussed. Sales of common clay in the U.S. increased from 26.2 Mt in 1996 to an estimated 26.5 Mt in 1997. The amount of common clay and shale used to produce structural clay products in 1997 was estimated at 13.8 Mt.
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Common Core Literacy Lesson Plans: Ready-to-Use Resources, K-5
ERIC Educational Resources Information Center
Davis, Lauren
2013-01-01
Schools nationwide are transitioning to the Common Core--our advice to you: Don't go it alone! Our new book, "Common Core Literacy Lesson Plans: Ready-to-Use Resources, K-5," shows you that teaching the Common Core State Standards in the elementary grades doesn't have to be intimidating! This easy-to-use guide provides model lesson plans for…
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Specialized Common Carriers: Long Distance Alternatives for Military Installations.
1984-03-01
military installation managers with a basic knowledge of how Specialized Common Carriers enter-f ed the telecommuunications market , what services...how Specialized Common Carriers .ntered the teleccumunicaticns market , what services Specialized Common Carriers offer, and how to obtain these...26 A. ATSTOS SEFIICES--THE MARKET STANDARD .... 26 E. SCC SVITCEID VOICE NETWORK SERVICES . . . 28 1. Dial Access Services . . . .. 28 2
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The Role of the Common Core in the Gubernatorial Elections of 2014
ERIC Educational Resources Information Center
Supovitz, Jonathan; Newman, Bobbi; Smith, Ariel
2014-01-01
After the Spring 2014 primaries, the Common Core State Standards were viewed as a political hot potato. As former Arkansas Governor Mike Huckabee said, "the Common Core has become toxic, I think it's radioactive…It has become an incredibly controversial topic on both the left and the right." Even so, the Common Core turned out to play a…
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Code of Federal Regulations, 2010 CFR
2010-07-01
... maintain an SO2 continuous emission monitoring system and flow monitoring system in the duct to the common... emission monitoring system and flow monitoring system in the common stack and combine emissions for the... continuous emission monitoring system and flow monitoring system in the duct to the common stack from each...
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ERIC Educational Resources Information Center
Achieve, Inc., 2010
2010-01-01
Through the Common Core State Standards (CCSS) Initiative, states and territories have collaborated in the development of a common core of standards in English Language Arts and mathematics for grades kindergarten through twelve that are now being adopted by states. Designed not only for the purpose of providing strong, shared expectations, the…
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Common Mental Disorders among Occupational Groups: Contributions of the Latent Class Model
Martins Carvalho, Fernando; de Araújo, Tânia Maria
2016-01-01
Background. The Self-Reporting Questionnaire (SRQ-20) is widely used for evaluating common mental disorders. However, few studies have evaluated the SRQ-20 measurements performance in occupational groups. This study aimed to describe manifestation patterns of common mental disorders symptoms among workers populations, by using latent class analysis. Methods. Data derived from 9,959 Brazilian workers, obtained from four cross-sectional studies that used similar methodology, among groups of informal workers, teachers, healthcare workers, and urban workers. Common mental disorders were measured by using SRQ-20. Latent class analysis was performed on each database separately. Results. Three classes of symptoms were confirmed in the occupational categories investigated. In all studies, class I met better criteria for suspicion of common mental disorders. Class II discriminated workers with intermediate probability of answers to the items belonging to anxiety, sadness, and energy decrease that configure common mental disorders. Class III was composed of subgroups of workers with low probability to respond positively to questions for screening common mental disorders. Conclusions. Three patterns of symptoms of common mental disorders were identified in the occupational groups investigated, ranging from distinctive features to low probabilities of occurrence. The SRQ-20 measurements showed stability in capturing nonpsychotic symptoms. PMID:27630999
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Observations of territorial breeding common ravens caching eggs of greater sage-grouse
Howe, Kristy B.; Coates, Peter S.
2015-01-01
Previous investigations using continuous video monitoring of greater sage-grouse Centrocercus urophasianus nests have unambiguously identified common ravens Corvus corax as an important egg predator within the western United States. The quantity of greater sage-grouse eggs an individual common raven consumes during the nesting period and the extent to which common ravens actively hunt greater sage-grouse nests are largely unknown. However, some evidence suggests that territorial breeding common ravens, rather than nonbreeding transients, are most likely responsible for nest depredations. We describe greater sage-grouse egg depredation observations obtained opportunistically from three common raven nests located in Idaho and Nevada where depredated greater sage-grouse eggs were found at or in the immediate vicinity of the nest site, including the caching of eggs in nearby rock crevices. We opportunistically monitored these nests by counting and removing depredated eggs and shell fragments from the nest sites during each visit to determine the extent to which the common raven pairs preyed on greater sage-grouse eggs. To our knowledge, our observations represent the first evidence that breeding, territorial pairs of common ravens cache greater sage-grouse eggs and are capable of depredating multiple greater sage-grouse nests.
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Emergence of a Common Modeling Architecture for Earth System Science (Invited)
NASA Astrophysics Data System (ADS)
Deluca, C.
2010-12-01
Common modeling architecture can be viewed as a natural outcome of common modeling infrastructure. The development of model utility and coupling packages (ESMF, MCT, OpenMI, etc.) over the last decade represents the realization of a community vision for common model infrastructure. The adoption of these packages has led to increased technical communication among modeling centers and newly coupled modeling systems. However, adoption has also exposed aspects of interoperability that must be addressed before easy exchange of model components among different groups can be achieved. These aspects include common physical architecture (how a model is divided into components) and model metadata and usage conventions. The National Unified Operational Prediction Capability (NUOPC), an operational weather prediction consortium, is collaborating with weather and climate researchers to define a common model architecture that encompasses these advanced aspects of interoperability and looks to future needs. The nature and structure of the emergent common modeling architecture will be discussed along with its implications for future model development.
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A case of nontraumatic gas gangrene in a common marmoset (Callithrix jacchus).
Yasuda, Masahiko; Inoue, Takashi; Ueno, Masami; Morita, Hanako; Hayashimoto, Nobuhito; Kawai, Kenji; Itoh, Toshio
2016-01-01
The common marmoset is widely used in neuroscience and regenerative medicine research. However, information concerning common marmoset disorders, particularly infectious diseases, is scarce. Here, we report a case of a female common marmoset that died suddenly due to gas gangrene. The animal presented with gaseous abdominal distention at postmortem, and Clostridium perfringens type A was isolated from several tissues. Vacuoles, a Gram-positive bacteremia and intravascular hemolysis were observed microscopically in the muscles, liver and lungs. On the basis of these findings, we diagnosed nontraumatic gas gangrene caused by Clostridium perfringens type A in this common marmoset.
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A case of nontraumatic gas gangrene in a common marmoset (Callithrix jacchus)
YASUDA, Masahiko; INOUE, Takashi; UENO, Masami; MORITA, Hanako; HAYASHIMOTO, Nobuhito; KAWAI, Kenji; ITOH, Toshio
2015-01-01
The common marmoset is widely used in neuroscience and regenerative medicine research. However, information concerning common marmoset disorders, particularly infectious diseases, is scarce. Here, we report a case of a female common marmoset that died suddenly due to gas gangrene. The animal presented with gaseous abdominal distention at postmortem, and Clostridium perfringens type A was isolated from several tissues. Vacuoles, a Gram-positive bacteremia and intravascular hemolysis were observed microscopically in the muscles, liver and lungs. On the basis of these findings, we diagnosed nontraumatic gas gangrene caused by Clostridium perfringens type A in this common marmoset. PMID:26156080
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Mi, Chris; Li, Siqi
2017-01-31
A bidirectional AC-DC converter is presented with reduced passive component size and common mode electro-magnetic interference. The converter includes an improved input stage formed by two coupled differential inductors, two coupled common and differential inductors, one differential capacitor and two common mode capacitors. With this input structure, the volume, weight and cost of the input stage can be reduced greatly. Additionally, the input current ripple and common mode electro-magnetic interference can be greatly attenuated, so lower switching frequency can be adopted to achieve higher efficiency.
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... cancer the three most common cancers are: Prostate cancer Lung cancer Colorectal cancer In US women, other than ... cancer the three most common cancers are: Breast cancer Lung cancer Colorectal cancer Some cancers are more common ...
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Simancas-Racines, Daniel; Guerra, Claudia V; Hidalgo, Ricardo
2013-06-12
The common cold is a spontaneously remitting infection of the upper respiratory tract, characterised by a runny nose, nasal congestion, sneezing, cough, malaise, sore throat and fever (usually < 37.8˚C). The widespread morbidity it causes worldwide is related to its ubiquitousness rather than its severity. The development of vaccines for the common cold has been difficult because of antigenic variability of the common cold virus and the indistinguishable multiple other viruses and even bacteria acting as infective agents. There is uncertainty regarding the efficacy and safety of interventions for preventing the common cold in healthy people. To assess the clinical effectiveness and safety of vaccines for preventing the common cold in healthy people. We searched CENTRAL (2012, Issue 12), MEDLINE (1948 to January week 1, 2013), EMBASE (1974 to January 2013), CINAHL (1981 to January 2013) and LILACS (1982 to January 2013). Randomised controlled trials (RCTs) of any virus vaccines to prevent the common cold in healthy people. Two review authors independently evaluated methodological quality and extracted trial data. Disagreements were resolved by discussion or by consulting a third review author. This review included one RCT with 2307 healthy participants; all of them were analysed. This trial compared the effect of an adenovirus vaccine against a placebo. No statistically significant difference in common cold incidence was found: there were 13 events in 1139 participants in the vaccines group and 14 events in 1168 participants in the placebo group; risk ratio (RR) 0.95, 95% confidence interval (CI) 0.45 to 2.02, P = 0.90). No adverse events related to the live vaccine were reported. This Cochrane review has found a lack of evidence on the effects of vaccines for the common cold in healthy people. Only one RCT was found and this did not show differences between comparison groups; it also had a high risk of bias. There are no conclusive data to support the use of vaccines for preventing the common cold in healthy people. We identified the need for well-designed, adequately powered RCTs to investigate vaccines for the common cold in healthy people. Unless RCTs provide evidence of a treatment effect and the trade-off between potential benefits and harms is established, policy-makers, clinicians and academics should not recommend the use of vaccines for preventing the common cold in healthy people. Any future trials on medical treatments for preventing the common cold should assess a variety of virus vaccines for this condition. Outcome measures should include common cold incidence, vaccine safety and mortality related to the vaccine.
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Reinprecht, Yarmilla; Yadegari, Zeinab; Perry, Gregory E.; Siddiqua, Mahbuba; Wright, Lori C.; McClean, Phillip E.; Pauls, K. Peter
2013-01-01
Legumes contain a variety of phytochemicals derived from the phenylpropanoid pathway that have important effects on human health as well as seed coat color, plant disease resistance and nodulation. However, the information about the genes involved in this important pathway is fragmentary in common bean (Phaseolus vulgaris L.). The objectives of this research were to isolate genes that function in and control the phenylpropanoid pathway in common bean, determine their genomic locations in silico in common bean and soybean, and analyze sequences of the 4CL gene family in two common bean genotypes. Sequences of phenylpropanoid pathway genes available for common bean or other plant species were aligned, and the conserved regions were used to design sequence-specific primers. The PCR products were cloned and sequenced and the gene sequences along with common bean gene-based (g) markers were BLASTed against the Glycine max v.1.0 genome and the P. vulgaris v.1.0 (Andean) early release genome. In addition, gene sequences were BLASTed against the OAC Rex (Mesoamerican) genome sequence assembly. In total, fragments of 46 structural and regulatory phenylpropanoid pathway genes were characterized in this way and placed in silico on common bean and soybean sequence maps. The maps contain over 250 common bean g and SSR (simple sequence repeat) markers and identify the positions of more than 60 additional phenylpropanoid pathway gene sequences, plus the putative locations of seed coat color genes. The majority of cloned phenylpropanoid pathway gene sequences were mapped to one location in the common bean genome but had two positions in soybean. The comparison of the genomic maps confirmed previous studies, which show that common bean and soybean share genomic regions, including those containing phenylpropanoid pathway gene sequences, with conserved synteny. Indels identified in the comparison of Andean and Mesoamerican common bean 4CL gene sequences might be used to develop inter-pool phenylpropanoid pathway gene-based markers. We anticipate that the information obtained by this study will simplify and accelerate selections of common bean with specific phenylpropanoid pathway alleles to increase the contents of beneficial phenylpropanoids in common bean and other legumes. PMID:24046770
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Quality Characteristics of Appalachian Red Oak Lumber
Janice K Wiedenbeck; Charles J. Gatchell; Elizabeth S. Walker
1995-01-01
Red oak lumber defect information derived from a well-constructed board data bank was analyzed. The potential utility of No. 1 Common and No. 2A Common lumber is indicated by the finding that 23 percent of the No. 1 Common boards and 35 percent of the No. 2A Common boards in the data bank contain clear-face cutting percentages that meet the minimum requirement for the...
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ERIC Educational Resources Information Center
Wei, Youhua; Morgan, Rick
2016-01-01
As an alternative to common-item equating when common items do not function as expected, the single-group growth model (SGGM) scaling uses common examinees or repeaters to link test scores on different forms. The SGGM scaling assumes that, for repeaters taking adjacent administrations, the conditional distribution of scale scores in later…
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Federal Register 2010, 2011, 2012, 2013, 2014
2011-11-08
.... FSIS-2010-0012] RIN 0583-AD41 Common or Usual Name for Raw Meat and Poultry Products Containing Added... for 60 days the comment period for the proposed rule, ``Common or Usual Name for Raw Meat and Poultry..., FSIS published the proposed rule ``Common or Usual Name for Raw Meat and Poultry Products Containing...
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A Capital case for common names of species of fishes--a white crappie or a White Crappie
Joseph S. Nelson; Wayne C. Stames; Melvin L. Warren
2002-01-01
Common names of fishes are an important and often primary means of fish biologists communicating with each other and with the public. Although common names will never replace scientific names, they are indispensable in many areas such as fisheries science, management, administration, and education. In recognition of the important role common names play in communicating...
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ERIC Educational Resources Information Center
Umberger, Mary L.
2002-01-01
In 1987, Frank and Deborah Popper, a planner/geographer team from Rutgers University, proposed the Buffalo Commons. If implemented, the Buffalo Commons would have preserved a large area of the Great Plains, including land in ten states, in a national park to be used by exiting Native American reservations, and for the reintroduction of buffalo.
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ERIC Educational Resources Information Center
Michaelides, Michalis P.; Haertel, Edward H.
2014-01-01
The standard error of equating quantifies the variability in the estimation of an equating function. Because common items for deriving equated scores are treated as fixed, the only source of variability typically considered arises from the estimation of common-item parameters from responses of samples of examinees. Use of alternative, equally…
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Common Core Literacy Lesson Plans: Ready-to-Use Resources, 9-12
ERIC Educational Resources Information Center
Davis, Lauren
2013-01-01
Schools nationwide are transitioning to the Common Core--our advice to you: Be prepared, but don't go it alone! Our new book, "Common Core Literacy Lesson Plans: Ready-to-Use Resources, 9-12," shows you that teaching the Common Core State Standards in high school doesn't have to be intimidating! This easy-to-use guide meets the particular needs of…
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Common Core Literacy Lesson Plans: Ready-to-Use Resources, 6-8
ERIC Educational Resources Information Center
Davis, Lauren
2013-01-01
Schools nationwide are transitioning to the Common Core--our advice to you: Don't go it alone! Our new book, "Common Core Literacy Lesson Plans: Ready-to-Use Resources, 6-8," shows you that teaching the Common Core State Standards in the middle grades doesn't have to be intimidating! This easy-to-use guide meets the particular needs of middle…
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ERIC Educational Resources Information Center
Fraser, J. Scott; Solovey, Andrew D.; Grove, David; Lee, Mo Yee; Greene, Gilbert J.
2012-01-01
A moderate common factors approach is proposed as a synthesis or middle path to integrate common and specific factors in evidence-based approaches to high-risk youth and families. The debate in family therapy between common and specific factors camps is reviewed and followed by suggestions from the literature for synthesis and creative flexibility…
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ERIC Educational Resources Information Center
Dentith, Audrey M.; Root, Debra A.
2012-01-01
This paper reports on a summer program for educators that sought to prepare them to teach in and through the "cultural commons" in the summer of 2012. The 5-day Academy for the Critical Inquiry of the Cultural Commons set out to foster knowledge of the cultural commons and their importance in the forging of ecological intelligence among…
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Chen, Lin; Dong, Chuanju; Kong, Shengnan; Zhang, Jiangfan; Li, Xuejun; Xu, Peng
2017-09-05
Bone morphogenetic proteins (Bmps) are a group of signaling molecules known to play important roles during formation and maintenance of various organs, not only bone, but also muscle, blood and so on. Common carp (Cyprinus carpio) is one of the most intensively studied fish due to its economic and environmental importance. Besides, common carp has encountered an additional round of whole genome duplication (WGD) compared with many closely related diploid teleost, which make it one of the most important models for genome evolutionary studies in teleost. Comprehensive genome resources of common carp have been developed recently, which facilitate the thorough characterization of bmp gene family in the tetraploidized common carp genome. We identified a total of 44 bmps from the common carp genome, which are twice as many as that of zebrafish. Phylogenetic analysis revealed that most of bmps are highly conserved. Comparative analysis was performed across six typical vertebrate genomes. It appeared that all the bmp genes in common carp were duplicated. Obviously, the expansion of the bmp gene family in common carp was due to the latest additional round of whole genome duplication and made it more abundant than other diploid teleosts. Expression signatures were assessed in major tissues, including gill, intestine, liver, spleen, skin, heart, gonad, muscle, kidney, head kidney, brain and blood, which demonstrated the comprehensive expression profiles of bmp genes in the tetraploidized genome. Significant gene expression divergences were observed which revealed substantial functional divergences of those duplicated bmp genes post the latest WGD event. The conserved synteny blocks of bmp5s revealed the genome rearrangement of common carp post the 4R WGD. The whole set of bmp gene family in common carp provides insight into gene fate of tetraploidized common carp genome post recent WGD. Copyright © 2017. Published by Elsevier B.V.
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Common Misconceptions about Cholesterol
... Venous Thromboembolism Aortic Aneurysm More Common Misconceptions about Cholesterol Updated:Jan 29,2018 How much do you ... are some common misconceptions — and the truth. High cholesterol isn’t a concern for children. High cholesterol ...
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Barnes, Ethann R.; Knezevic, Stevan Z.; Sikkema, Peter H.; Lindquist, John L.; Jhala, Amit J.
2017-01-01
Common ragweed emerges early in the season in Nebraska, USA and is competitive with soybean; therefore, preplant herbicides are important for effective control. Glyphosate has been used as a preplant control option; however, confirmation of glyphosate-resistant (GR) common ragweed in Nebraska necessitates evaluating other herbicide options. The objectives of this study were to (1) evaluate the efficacy of preplant (PP) herbicides followed by (fb) glufosinate alone or in tank-mixture with imazethapyr, acetochlor, or S-metolachlor applied post-emergence (POST) for control of GR common ragweed in glufosinate-resistant soybean; (2) their effect on common ragweed density, biomass, and soybean yield; and (3) the partial economics of herbicide programs. A field experiment was conducted in a grower's field infested with GR common ragweed in Gage County, Nebraska, USA in 2015 and 2016. Preplant herbicide programs containing glufosinate, paraquat, 2,4-D, dimethenamid-P, cloransulam-methyl, or high rates of flumioxazin plus chlorimuron-ethyl provided 90–99% control of common ragweed at 21 d after treatment (DAT). The aforementioned PP herbicides fb a POST application of glufosinate alone or in tank-mixture with imazethapyr, acetochlor, or S-metolachlor controlled GR common ragweed 84–98% at soybean harvest, reduced common ragweed density (≤20 plants m−2) and biomass by ≥93%, and secured soybean yield 1,819–2,158 kg ha−1. The PP fb POST herbicide programs resulted in the highest gross profit margins (US$373–US$506) compared to PP alone (US$91) or PRE fb POST programs (US$158). The results of this study conclude that effective and economical control of GR common ragweed in glufosinate-resistant soybean is achievable with PP fb POST herbicide programs. PMID:28868065
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Fezeu, Léopold K; Batty, G David; Batty, David G; Gale, Catharine R; Kivimaki, Mika; Hercberg, Serge; Czernichow, Sebastien
2015-01-01
The direction of the association between mental health and adiposity is poorly understood. Our objective was to empirically examine this link in a UK study. This is a prospective cohort study of 3 388 people (men) aged ≥ 18 years at study induction who participated in both the UK Health and Lifestyle Survey at baseline (HALS-1, 1984/1985) and the re-survey (HALS-2, 1991/1992). At both survey examinations, body mass index, waist circumference and self-reported common mental disorder (the 30-item General Health Questionnaire, GHQ) were measured. Logistic regression models were used to compute odds ratios (OR) and accompanying 95% confidence intervals (CI) for the associations between (1) baseline common mental disorder (QHQ score > 4) and subsequent general and abdominal obesity and (2) baseline general and abdominal obesity and re-survey common mental disorders. After controlling for a range of covariates, participants with common mental disorder at baseline experienced greater odds of subsequently becoming overweight (women, OR: 1.30, 1.03 - 1.64; men, 1.05, 0.81 - 1.38) and obese (women, 1.26, 0.82 - 1.94; men, OR: 2.10, 1.23 - 3.55) than those who were free of common mental disorder. Similarly, having baseline common mental health disorder was also related to a greater risk of developing moderate (1.57, 1.21 - 2.04) and severe (1.48, 1.09 - 2.01) abdominal obesity (women only). Baseline general or abdominal obesity was not associated with the risk of future common mental disorder. These findings of the present study suggest that the direction of association between common mental disorders and adiposity is from common mental disorder to increased future risk of adiposity as opposed to the converse.
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Petrovan, Silviu O; Schmidt, Benedikt R
2016-01-01
Rare and threatened species are the most frequent focus of conservation science and action. With the ongoing shift from single-species conservation towards the preservation of ecosystem services, there is a greater need to understand abundance trends of common species because declines in common species can disproportionately impact ecosystems function. We used volunteer-collected data in two European countries, the United Kingdom (UK) and Switzerland, since the 1970s to assess national and regional trends for one of Europe's most abundant amphibian species, the common toad (Bufo bufo). Millions of toads were moved by volunteers across roads during this period in an effort to protect them from road traffic. For Switzerland, we additionally estimated trends for the common frog (Rana temporaria), a similarly widespread and common amphibian species. We used state-space models to account for variability in detection and effort and included only populations with at least 5 years of data; 153 populations for the UK and 141 for Switzerland. Common toads declined continuously in each decade in both countries since the 1980s. Given the declines, this common species almost qualifies for International Union for the Conservation of Nature (IUCN) red-listing over this period despite volunteer conservation efforts. Reasons for the declines and wider impacts remain unknown. By contrast, common frog populations were stable or increasing in Switzerland, although there was evidence of declines after 2003. "Toads on Roads" schemes are vital citizen conservation action projects, and the data from such projects can be used for large scale trend estimations of widespread amphibians. We highlight the need for increased research into the status of common amphibian species in addition to conservation efforts focusing on rare and threatened species.
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Distribution and habitat associations of juvenile Common Snook in the lower Rio Grande, Texas
Huber, Caleb G.; Grabowski, Timothy B.; Patino, Reynaldo; Pope, Kevin L.
2014-01-01
Common Snook Centropomus undecimalis were once abundant off the Texas coast, but these populations are now characterized by low abundance and erratic recruitment. Most research concerning Common Snook in North America has been conducted in Florida and very little is known about the specific biology and habitat needs of Common Snook in Texas. The primary objective of this study was to describe the habitat use patterns of juvenile Common Snook and their role in the fish assemblage in the lower portion of the Rio Grande, Texas. Secondarily, we documented the relationship between age and juvenile reproductive development. Fish were collected during January–March 2006 from the lower 51.5 km of the Rio Grande using a bottom trawl and boat-mounted electrofisher. Measurements of water quality and other habitat traits were recorded at each sampling site. We captured 225 Common Snook exclusively in freshwater habitats above river kilometer 12.9. The distribution of juvenile Common Snook was not random, but influenced primarily by turbidity and dissolved oxygen. Sex differentiation and gonadal development based on histological examination of gonads established that age-1 and age-2 Common Snook were juvenile, prepubertal males. There was no difference between the age groups in their overall distribution in the river. However, age-2 Common Snook were associated with deeper areas with faster currents, higher conductivity, and steeper banks. Overall, Common Snook in the lower Rio Grande show substantial differences in habitat use than their counterparts in other parts of the range of the species, but it is unclear whether this is due to differences in habitat availability, behavioral plasticity, or some combination thereof.
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Common Cold in Babies: Symptoms and Causes
... older children. Also, they have yet to develop immunity to many common infections. Within the first year ... lifetime. Also, some viruses don't produce lasting immunity. A common cold virus enters your baby's mouth, ...
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What Are Some Common Signs of Pregnancy?
... pregnancy? Share Facebook Twitter Pinterest Email Print What are some common signs of pregnancy? The primary sign ... always mean a woman is pregnant. Menstrual irregularities are common and can have a variety of causes, ...
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6 Common Cancers - Skin Cancer
... Bar Home Current Issue Past Issues 6 Common Cancers - Skin Cancer Past Issues / Spring 2007 Table of Contents For ... AP Photo/Herald-Mail, Kevin G. Gilbert Skin Cancer Skin cancer is the most common form of ...
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Common elements of adolescent prevention programs: minimizing burden while maximizing reach.
Boustani, Maya M; Frazier, Stacy L; Becker, Kimberly D; Bechor, Michele; Dinizulu, Sonya M; Hedemann, Erin R; Ogle, Robert R; Pasalich, Dave S
2015-03-01
A growing number of evidence-based youth prevention programs are available, but challenges related to dissemination and implementation limit their reach and impact. The current review identifies common elements across evidence-based prevention programs focused on the promotion of health-related outcomes in adolescents. We reviewed and coded descriptions of the programs for common practice and instructional elements. Problem-solving emerged as the most common practice element, followed by communication skills, and insight building. Psychoeducation, modeling, and role play emerged as the most common instructional elements. In light of significant comorbidity in poor outcomes for youth, and corresponding overlap in their underlying skills deficits, we propose that synthesizing the prevention literature using a common elements approach has the potential to yield novel information and inform prevention programming to minimize burden and maximize reach and impact for youth.
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Influence of sectioning location on age estimates from common carp dorsal spines
Watkins, Carson J.; Klein, Zachary B.; Terrazas, Marc M.; Quist, Michael C.
2015-01-01
Dorsal spines have been shown to provide precise age estimates for Common CarpCyprinus carpio and are commonly used by management agencies to gain information on Common Carp populations. However, no previous studies have evaluated variation in the precision of age estimates obtained from different sectioning locations along Common Carp dorsal spines. We evaluated the precision, relative readability, and distribution of age estimates obtained from various sectioning locations along Common Carp dorsal spines. Dorsal spines from 192 Common Carp were sectioned at the base (section 1), immediately distal to the basal section (section 2), and at 25% (section 3), 50% (section 4), and 75% (section 5) of the total length of the dorsal spine. The exact agreement and within-1-year agreement among readers was highest and the coefficient of variation lowest for section 2. In general, age estimates derived from sections 2 and 3 had similar age distributions and displayed the highest concordance in age estimates with section 1. Our results indicate that sections taken at ≤ 25% of the total length of the dorsal spine can be easily interpreted and provide precise estimates of Common Carp age. The greater consistency in age estimates obtained from section 2 indicates that by using a standard sectioning location, fisheries scientists can expect age-based estimates of population metrics to be more comparable and thus more useful for understanding Common Carp population dynamics.
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A comprehensive segmentation analysis of crude oil market based on time irreversibility
NASA Astrophysics Data System (ADS)
Xia, Jianan; Shang, Pengjian; Lu, Dan; Yin, Yi
2016-05-01
In this paper, we perform a comprehensive entropic segmentation analysis of crude oil future prices from 1983 to 2014 which used the Jensen-Shannon divergence as the statistical distance between segments, and analyze the results from original series S and series begin at 1986 (marked as S∗) to find common segments which have same boundaries. Then we apply time irreversibility analysis of each segment to divide all segments into two groups according to their asymmetry degree. Based on the temporal distribution of the common segments and high asymmetry segments, we figure out that these two types of segments appear alternately and do not overlap basically in daily group, while the common portions are also high asymmetry segments in weekly group. In addition, the temporal distribution of the common segments is fairly close to the time of crises, wars or other events, because the hit from severe events to oil price makes these common segments quite different from their adjacent segments. The common segments can be confirmed in daily group series, or weekly group series due to the large divergence between common segments and their neighbors. While the identification of high asymmetry segments is helpful to know the segments which are not affected badly by the events and can recover to steady states automatically. Finally, we rearrange the segments by merging the connected common segments or high asymmetry segments into a segment, and conjoin the connected segments which are neither common nor high asymmetric.
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Castro-Guerrero, Norma A; Isidra-Arellano, Mariel C; Mendoza-Cozatl, David G; Valdés-López, Oswaldo
2016-01-01
Common bean (Phaseolus vulgaris) was domesticated ∼8000 years ago in the Americas and today is a staple food worldwide. Besides caloric intake, common bean is also an important source of protein and micronutrients and it is widely appreciated in developing countries for their affordability (compared to animal protein) and its long storage life. As a legume, common bean also has the economic and environmental benefit of associating with nitrogen-fixing bacteria, thus reducing the use of synthetic fertilizers, which is key for sustainable agriculture. Despite significant advances in the plant nutrition field, the mechanisms underlying the adaptation of common bean to low nutrient input remains largely unknown. The recent release of the common bean genome offers, for the first time, the possibility of applying techniques and approaches that have been exclusive to model plants to study the adaptive responses of common bean to challenging environments. In this review, we discuss the hallmarks of common bean domestication and subsequent distribution around the globe. We also discuss recent advances in phosphate, iron, and zinc homeostasis, as these nutrients often limit plant growth, development, and yield. In addition, iron and zinc are major targets of crop biofortification to improve human nutrition. Developing common bean varieties able to thrive under nutrient limiting conditions will have a major impact on human nutrition, particularly in countries where dry beans are the main source of carbohydrates, protein and minerals.
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Analysis of koi herpesvirus latency in wild common carp and ornamental koi in Oregon, USA.
Xu, Jia-Rong; Bently, Jennifer; Beck, Linda; Reed, Aimee; Miller-Morgan, Tim; Heidel, Jerry R; Kent, Michael L; Rockey, Daniel D; Jin, Ling
2013-02-01
Koi herpesvirus (KHV) infection is associated with high mortalities in both common carp (Cyprinus carpio carpio) and koi carp (Cyprinus carpio koi) worldwide. Although acute infection has been reported in both domestic and wild common carp, the status of KHV latent infection is largely unknown in wild common carp. To investigate whether KHV latency is present in wild common carp, the distribution of KHV latent infection was investigated in two geographically distinct populations of wild common carp in Oregon, as well as in koi from an Oregon-based commercial supplier. Latent KHV infection was demonstrated in white blood cells from each of these populations. Although KHV isolated from acute infections has two distinct genetic groups, Asian and European, KHV detected in wild carp has not been genetically characterized. DNA sequences from ORF 25 to 26 that are unique between Asian and European were investigated in this study. KHV from captive koi and some wild common carp were found to have ORF-25-26 sequences similar to KHV-J (Asian), while the majority of KHV DNA detected in wild common carp has similarity to KHV-U/-I (European). In addition, DNA sequences from IL-10, and TNFR were sequenced and compared with no differences found, which suggests immune suppressor genes of KHV are conserved between KHV in wild common carp and koi, and is consistent with KHV-U, -I, -J. Copyright © 2012 Elsevier B.V. All rights reserved.
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To Make Long Character-Marked Cuttings From Low-Grade Yellow-Poplar Lumber - Rip First
Philip A. Araman
1979-01-01
Long, character-marked furniture cuttings are easily obtained when low-grade (2A and 2B Common) yellow-poplar lumber is first ripped into strips and then crosscut to remove objectionable defects. Overall yields of character-marked material using this procedure were 78% from 1 Common and 2A Common and 70% from 2B Common yellow-poplar lumber. Furthermore, 82% of the 1...
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ERIC Educational Resources Information Center
Dolan, Conor V.; Colom, Roberto; Abad, Francisco J.; Wicherts, Jelte M.; Hessen, David J.; van de Sluis, Sophie
2006-01-01
We investigated sex effects and the effects of educational attainment (EA) on the covariance structure of the WAIS-III in a subsample of the Spanish standardization data. We fitted both first order common factor models and second order common factor models. The latter include general intelligence ("g") as a second order common factor.…
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Common base amplifier with 7 - dB gain at 176 GHz in InP mesa DHBT technology
NASA Technical Reports Server (NTRS)
Samoska, Lorene; Paidi, V.; Griffith, Z.; Dahlstrom, M.; Wei, Y.; Urteaga, M.; Rodell, M. J. W.; Fung, A.
2004-01-01
We report a single stage tunded amplifier that exhibits 7 dB small signal gain at 176 GHz. Common Base topology is chosen as it has the best maximum stable gain (MSG) in this frequency band when compared to common emitter and common collector topologies. The amplifiers are designed and fabricated in InP mesa double heterojunction bipolar transistor (DHBT) technology.
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ERIC Educational Resources Information Center
Krashen, Stephen
2014-01-01
This author contends that there never has been a need for the Common Core State Standards (CCSS), and there is no evidence that it will do students any good. The Common Core ignores the real problem in American education: poverty. The Common Core movement will be a disaster for libraries and will have a negative impact on nearly every aspect of…
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The Advantages and Disadvantages of Seeking Commonality in Military Equipment
2011-01-01
rand 2011 www.rand.org The Advantages and Disadvantages of Seeking Commonality in Military Equipment I ncreasingly, the Army and the Department...advantages and disadvantages of commonality and developed a decision aid to help Army policymakers manage these tradeoffs. The study drew upon...TITLE AND SUBTITLE The Advantages and Disadvantages of Seeking Commonality in Military Equipment 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM
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ERIC Educational Resources Information Center
Jacoby, Pat; Vasinda, Sheri
2014-01-01
In the Winter 2013 edition of the "Texas Journal of Literacy Education," we announced that a special task force from the TALE board would be sharing the common ground among the Texas Essential Knowledge and Skills (TEKS), Common Core State Standards (CCSS), and the College and Career Readiness Standards (CCRS). In that first edition, we…
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1992 Data Bank for Red Oak Lumber
Charles J. Gatchell; Janice K. Wiedenbeck; Elizabeth S. Walker; Elizabeth S. Walker
1992-01-01
The 1992 Data Bank for Red Oak Lumber is a collection of fully described FAS, Selects, No. 1 Common, and No. 2A Common boards (a total of 1,578 at present). The data bank has two unique features to aid in sample selection. The first feature is the double grading of FAS, No. 1 Common, and No. 2A Common boards to reflect the surface area in grading cuttings when grading...
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Reasons for the preference of clinic visits to self-medication by common cold patients in Japan.
Tsutsumi, Madoka; Shaku, Fumio; Ozone, Sachiko; Sakamoto, Naoto; Maeno, Tetsuhiro
2017-12-01
Many Japanese visit medical institutions for common cold treatment, which can cause congestion in these institutions and an increase in medical expenses, although the common cold can be treated sufficiently through self-medication. Therefore, to elucidate the reasons individuals with common colds do not use over-the-counter (OTC) medication, we conducted an investigation using a self-administered inquiry sheet to determine reasons for clinic visits and for the avoidance of OTC medication. The study was of patients with self-diagnosed common cold symptoms using an anonymous self-report questionnaire. Of the 471 patients administered the questionnaire, 442 responded. The analysis was focused on the 37 patients who responded that they had considered using OTC medication before coming to the clinic but decided against it and came to the clinic instead. The majority responded positively saying that they felt reassured when seen by a physician (91.9%) and that their common cold was cured more rapidly (89.2%). It can be presumed that many patients with common colds visit medical institutions because they feel reassured and feel that their symptoms improve at a quicker rate. The findings of this study indicated that there is a need for accurate information and relief from anxiety for patients regarding the common cold.
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Common mental disorders and intimate partner violence in pregnancy.
Ludermir, Ana Bernarda; Valongueiro, Sandra; Araújo, Thália Velho Barreto de
2014-02-01
To investigate the association between common mental disorders and intimate partner violence during pregnancy. A cross sectional study was carried out with 1,120 pregnant women aged 18-49 years old, who were registered in the Family Health Program in the city of Recife, Northeastern Brazil, between 2005 and 2006. Common mental disorders were assessed using the Self-Reporting Questionnaire (SRQ-20). Intimate partner violence was defined as psychologically, physically and sexually abusive acts committed against women by their partners. Crude and adjusted odds ratios were estimated for the association studied utilizing logistic regression analysis. The most common form of partner violence was psychological. The prevalence of common mental disorders was 71.0% among women who reported all form of violence in pregnancy and 33.8% among those who did not report intimate partner violence. Common mental disorders were associated with psychological violence (OR 2.49, 95%CI 1.8;3.5), even without physical or sexual violence. When psychological violence was combined with physical or sexual violence, the risk of common mental disorders was even higher (OR 3.45; 95%CI 2.3;5.2). Being assaulted by someone with whom you are emotionally involved can trigger feelings of helplessness, low self-esteem and depression. The pregnancy probably increased women`s vulnerability to common mental disorders.
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Salgado Kent, Chandra; Donnelly, David; Weir, Jeffrey; Bilgmann, Kerstin
2016-01-01
Short-beaked common dolphins (Delphinus delphis) are typically considered highly mobile, offshore delphinids. This study assessed the residency of a small community of short-beaked common dolphins in the shallow, urbanized Port Phillip Bay, south-eastern Australia. The ability to identify common dolphins by their dorsal fin markings and coloration using photo-identification was also investigated. Systematic and non-systematic boat surveys were undertaken between 2007 and 2014. Results showed that 13 adult common dolphins and their offspring inhabit Port Phillip Bay, of which 10 adults exhibit residency to the bay. The majority of these adults are reproductively active females, suggesting that female philopatry may occur in the community. Systematic surveys conducted between 2012 and 2014 revealed that the dolphins were found in a median water depth of 16 m and median distance of 2.2 km from the coast. The shallow, urbanized habitat of this resident common dolphin community is atypical for this species. As a result, these common dolphins face threats usually associated with inshore bottlenose dolphin communities. We suggest that the Port Phillip Bay common dolphin community is considered and managed separate to those outside the embayment and offshore to ensure the community's long-term viability and residency in the bay. PMID:27703709
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Common Cause Failure Modeling: Aerospace Versus Nuclear
NASA Technical Reports Server (NTRS)
Stott, James E.; Britton, Paul; Ring, Robert W.; Hark, Frank; Hatfield, G. Spencer
2010-01-01
Aggregate nuclear plant failure data is used to produce generic common-cause factors that are specifically for use in the common-cause failure models of NUREG/CR-5485. Furthermore, the models presented in NUREG/CR-5485 are specifically designed to incorporate two significantly distinct assumptions about the methods of surveillance testing from whence this aggregate failure data came. What are the implications of using these NUREG generic factors to model the common-cause failures of aerospace systems? Herein, the implications of using the NUREG generic factors in the modeling of aerospace systems are investigated in detail and strong recommendations for modeling the common-cause failures of aerospace systems are given.
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Computer Graphic Representation of Remote Environment Using Position Tactile Sensors.
1981-08-01
200,3),M(100,3) COMMON /FACT/IFMAX,NX(30),NA,IPS.’ NCON,NPOL,ICCN, 1 IVECT,ISUP,IRX COMMON /IPTPs/ IANG(100,2) , ICHECK , VEX COMMON /DISPL/ICM,XXD,XYD...IDuM1(3100),IFc(200,3;,N-(100,3) COMMON /FACT/ IFMAXNX(30),NA,IsiTCON,NPOL COMMON /IPTPS/ IANG(100,2) , ICHECK ,VEX,IFCC C FIND ALTERNATE SET OF POINTS Mi...ILF(M1 .EQ.M2)RETURN CALL SEARCH(MlI,M2,J,I) OUT OF THE PAGfl IF(J.NE.O)RETURN IS OUTSIDE THE C IF ICHECK =2 FORCE FACE’ CHANGE POLYHEDRON IF(ICHECK.EQ
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Common peroneal neuropathy related to cryotherapy and compression in a footballer.
Babwah, Terence
2011-01-01
This report describes the effect of excessive cooling with ice, and compression with a plastic wrap on the common peroneal nerve (CPN) for 90 minutes in a professional footballer, which led to a common peroneal nerve palsy and a resulting footdrop. It highlights the need to be cautious with regards to the duration and frequency of icing as well as the choice of anchoring material when applying ice to injured areas that have superficial nerves passing nearby. Full recovery of the CPN function occurred in this athlete after five weeks. The major causes of footdrop and common causes of common peroneal neuropathy are discussed.
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Space biology initiative program definition review. Trade study 4: Design modularity and commonality
NASA Technical Reports Server (NTRS)
Jackson, L. Neal; Crenshaw, John, Sr.; Davidson, William L.; Herbert, Frank J.; Bilodeau, James W.; Stoval, J. Michael; Sutton, Terry
1989-01-01
The relative cost impacts (up or down) of developing Space Biology hardware using design modularity and commonality is studied. Recommendations for how the hardware development should be accomplished to meet optimum design modularity requirements for Life Science investigation hardware will be provided. In addition, the relative cost impacts of implementing commonality of hardware for all Space Biology hardware are defined. Cost analysis and supporting recommendations for levels of modularity and commonality are presented. A mathematical or statistical cost analysis method with the capability to support development of production design modularity and commonality impacts to parametric cost analysis is provided.
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[The effect of zinc therapy on common cold--a survey of a Cochrane review].
Valentiner-Branth, Palle
2012-01-09
The Cochrane review "Zinc and the common cold" included 15 randomized controlled double-blind trials. It was concluded, that zinc would shorten the duration of the episode of common cold and also could be used as a prevention so that the risk of developing an episode of common cold would be decreased. It is too early to give general recommendations for the use of zinc as we do not have sufficient knowledge about the optimal dose, formulation and duration of treatment. Further research should focus on the effect of zinc in patients who are at increased risk of developing complications after common cold.
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77 FR 22322 - Common Formats for Patient Safety Data Collection and Event Reporting
Federal Register 2010, 2011, 2012, 2013, 2014
2012-04-13
... Safety Databases (NPSD). The Common Formats include two general types of formats, generic and event... Common Formats. The inventory includes many systems from the private sector, including prominent academic...
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What Are Some Common Complications During Labor and Delivery?
... complications? Share Facebook Twitter Pinterest Email Print What are some common complications during labor and delivery? Each ... as necessary. Some of the more common complications are: 1 , 2 Labor that does not progress. Sometimes ...
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Age effect in generating mental images of buildings but not common objects.
Piccardi, L; Nori, R; Palermo, L; Guariglia, C; Giusberti, F
2015-08-18
Imagining a familiar environment is different from imagining an environmental map and clinical evidence demonstrated the existence of double dissociations in brain-damaged patients due to the contents of mental images. Here, we assessed a large sample of young and old participants by considering their ability to generate different kinds of mental images, namely, buildings or common objects. As buildings are environmental stimuli that have an important role in human navigation, we expected that elderly participants would have greater difficulty in generating images of buildings than common objects. We found that young and older participants differed in generating both buildings and common objects. For young participants there were no differences between buildings and common objects, but older participants found easier to generate common objects than buildings. Buildings are a special type of visual stimuli because in urban environments they are commonly used as landmarks for navigational purposes. Considering that topographical orientation is one of the abilities mostly affected in normal and pathological aging, the present data throw some light on the impaired processes underlying human navigation. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
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Kafemann, R.; Thiel, R.; Finn, J.E.; Neukamm, R.
1998-01-01
Abundance and biomass data for juveniles and adults, length frequency histograms and the electron microprobe analysis (EPMA) of otoliths were used to indicate density, migration and reproduction of common bream Abramis brama in the Kiel Canal drainage, Germany. The reproduction of common bream was primarily restricted to two types of spawning habitats: one in the Haaler Au, a freshwater tributary and another in shallow, oligohaline portion of the main Canal. Both spawning habitats were morphologically characterized as shallow with submerged vegetation. During April to June concentrations of spawners were observed, whereas age-0 common bream dominated from August through December. The distribution of age-0 common bream was primarily restricted to fresh and oligohaline waters. Outside the spawning season, the distribution of common bream was less obvious. Adult fish were more widely distributed within the Canal, indicating a tolerance for higher salinities. During the spawning season common bream seem to show an exceptional mobility between spawning and feeding habitats, which are denoted by different salinities.
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Not all carp are created equal: Impacts of broadband sound on common carp swimming behavior
Murchy, Kelsie; Vetter, Brooke J.; Brey, Marybeth; Amberg, Jon J.; Gaikowski, Mark; Mensinger, Allen F.
2016-01-01
Bighead carp (Hypophthalmichthys nobilis), silver carp (H. molitrix) (hereafter: bigheaded carps), and common carp (Cyprinus carpio) are invasive fish causing negative impacts throughout their North American range. To control their movements, non-physical barriers are being developed. Broadband sound (0.06 to 10 kHz) has shown potential as an acoustic deterrent for bigheaded carps, but the response of common carp to broadband sound has not been evaluated. Since common carp are ostariophysians, possessing Weberian ossicles similar to bigheaded carps, it is possible that sound can be used as an acoustical deterrent for all three species. Behavioral responses to a broadband sound were evaluated for common carp in an outdoor concrete pond. Common carp responded a median of 3.0 (1st Q: 1.0, 3rd Q: 6.0) consecutive times to the broadband sound which was lower than silver carp and bighead carp to the same stimulus. The current study shows that common carp demonstrate an inconsistent negative phonotaxis response to a broadband sound, and seem to habituate to the sound quickly.
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Ward, C; Lucas, M; Piris, J; Collier, J; Chapel, H
2008-09-01
Patients with common variable immunodeficiency disorders are monitored for liver function test abnormalities. A proportion of patients develop deranged liver function and some also develop hepatomegaly. We investigated the prevalence of abnormalities and types of liver disease, aiming to identify those at risk and determine outcomes. The local primary immunodeficiency database was searched for patients with a common variable immunodeficiency disorder and abnormal liver function and/or a liver biopsy. Patterns of liver dysfunction were determined and biopsies reviewed. A total of 47 of 108 patients had deranged liver function, most commonly raised alkaline phosphatase levels. Twenty-three patients had liver biopsies. Nodular regenerative hyperplasia was found in 13 of 16 with unexplained pathology. These patients were more likely to have other disease-related complications of common variable immunodeficiency disorders, in particular non-coeliac (gluten insensitive) lymphocytic enteropathy. However, five had no symptoms of liver disease and only one died of liver complications. Nodular regenerative hyperplasia is a common complication of common variable immunodeficiency disorders but was rarely complicated by portal hypertension.
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Charles J. Gatchell; Charles J. Gatchell
1990-01-01
Computer simulation was used to gang rip No. 1 and No. 2 Common red oak boards before and after removal of crook. While No. 1 Common produced slightly more total yield, the part yields were very similar. No. 1 Common was superior only in yielding 75-inch-long pieces. Either grade is an excellent choice for the furniture and cabinet industries.
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A Methodology to Improving Unity of Effort for Mission Partner Planning
2014-06-01
REPORT TYPE 3. DATES COVERED 00-00-2014 to 00-00-2014 4. TITLE AND SUBTITLE A Methodology to Improving Unity of Effort for Mission Partner... language , or better yet, use a common lexicon (common definitions and terms for greater understanding). One fundamental step toward developing...to attempt to develop strong relationships while learning to speak each other’s language , or better yet, use a common lexicon (common definitions and
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ERIC Educational Resources Information Center
Neem, Johann N.
2018-01-01
The Common Core does not advance democratic education. Far from it, the opening section of the language standards argues that the goal of public K-12 education is "college and career readiness." Only at the end of their introductory section do the Common Core's authors suggest that K-12 education has any goals beyond the economic:…
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Chemical and Common Burns in Children.
Yin, Shan
2017-05-01
Burns are a common cause of preventable morbidity and mortality in children. Thermal and chemical burns are the most common types of burns. Their clinical appearance can be similar and the treatment is largely similar. Thermal burns in children occur primarily after exposure to a hot surface or liquid, or contact with fire. Burns are typically classified based on the depth and total body surface area, and the severity and onset of the burn can also depend on the temperature and duration of contact. Chemical burns are caused by chemicals-most commonly acids and alkalis-that can damage the skin on contact. In children, the most common cause of chemical burns is from household products such as toilet bowl cleaners, drain cleaners, detergents, and bleaches. Mild chemical burns generally cause redness and pain and can look similar to other common rashes or skin infections, whereas severe chemical burns are more extreme and may cause redness, blistering, skin peeling, and swelling.
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A Method for Analyzing Commonalities in Clinical Trial Target Populations
He, Zhe; Carini, Simona; Hao, Tianyong; Sim, Ida; Weng, Chunhua
2014-01-01
ClinicalTrials.gov presents great opportunities for analyzing commonalities in clinical trial target populations to facilitate knowledge reuse when designing eligibility criteria of future trials or to reveal potential systematic biases in selecting population subgroups for clinical research. Towards this goal, this paper presents a novel data resource for enabling such analyses. Our method includes two parts: (1) parsing and indexing eligibility criteria text; and (2) mining common eligibility features and attributes of common numeric features (e.g., A1c). We designed and built a database called “Commonalities in Target Populations of Clinical Trials” (COMPACT), which stores structured eligibility criteria and trial metadata in a readily computable format. We illustrate its use in an example analytic module called CONECT using COMPACT as the backend. Type 2 diabetes is used as an example to analyze commonalities in the target populations of 4,493 clinical trials on this disease. PMID:25954450
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Lu, Baiyi; Li, Maiquan; Yin, Ran
2016-07-29
Edible flowers contain numerous phytochemicals which contribute to their health benefits, and consumption of edible flowers has increased significantly in recent years. While many researchers have been conducted, no literature review of the health benefits of common edible flowers and their phytochemicals has been compiled. This review aimed to present the findings of research conducted from 2000 to 2015 on the species, traditional application, phytochemicals, health benefits, and the toxicology of common edible flowers. It was found in 15 species of common edible flowers that four flavonols, three flavones, four flavanols, three anthocyanins, three phenolic acids and their derivatives were common phytochemicals and they contributed to the health benefits such as anti-oxidant, anti-inflammatory, anti-cancer, anti-obesity, and neuroprotective effect. Toxicology studies have been conducted to evaluate the safety of common edible flowers and provide information on their dosages and usages.
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The Human Phenotype Ontology: Semantic Unification of Common and Rare Disease
Groza, Tudor; Köhler, Sebastian; Moldenhauer, Dawid; Vasilevsky, Nicole; Baynam, Gareth; Zemojtel, Tomasz; Schriml, Lynn Marie; Kibbe, Warren Alden; Schofield, Paul N.; Beck, Tim; Vasant, Drashtti; Brookes, Anthony J.; Zankl, Andreas; Washington, Nicole L.; Mungall, Christopher J.; Lewis, Suzanna E.; Haendel, Melissa A.; Parkinson, Helen; Robinson, Peter N.
2015-01-01
The Human Phenotype Ontology (HPO) is widely used in the rare disease community for differential diagnostics, phenotype-driven analysis of next-generation sequence-variation data, and translational research, but a comparable resource has not been available for common disease. Here, we have developed a concept-recognition procedure that analyzes the frequencies of HPO disease annotations as identified in over five million PubMed abstracts by employing an iterative procedure to optimize precision and recall of the identified terms. We derived disease models for 3,145 common human diseases comprising a total of 132,006 HPO annotations. The HPO now comprises over 250,000 phenotypic annotations for over 10,000 rare and common diseases and can be used for examining the phenotypic overlap among common diseases that share risk alleles, as well as between Mendelian diseases and common diseases linked by genomic location. The annotations, as well as the HPO itself, are freely available. PMID:26119816
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NASA Astrophysics Data System (ADS)
Puchala, Brian; Tarcea, Glenn; Marquis, Emmanuelle. A.; Hedstrom, Margaret; Jagadish, H. V.; Allison, John E.
2016-08-01
Accelerating the pace of materials discovery and development requires new approaches and means of collaborating and sharing information. To address this need, we are developing the Materials Commons, a collaboration platform and information repository for use by the structural materials community. The Materials Commons has been designed to be a continuous, seamless part of the scientific workflow process. Researchers upload the results of experiments and computations as they are performed, automatically where possible, along with the provenance information describing the experimental and computational processes. The Materials Commons website provides an easy-to-use interface for uploading and downloading data and data provenance, as well as for searching and sharing data. This paper provides an overview of the Materials Commons. Concepts are also outlined for integrating the Materials Commons with the broader Materials Information Infrastructure that is evolving to support the Materials Genome Initiative.
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Presentation of Class 1 designs for a family of commuter airplanes
NASA Technical Reports Server (NTRS)
Creighton, Tom; Dragush, George; Hendrich, Louis; Hensley, Doug; Morgan, Louise; Oxendine, Charles; Remen, John; Robinson, Terry; Russell, Mark; Swift, Jerry
1986-01-01
The Class 1 configuration designs of a family of commuter aircraft are presented. The proposed aircraft will have a capacity of from 25 to 100 passengers. They are to have the following common features: (1) 2 aft fuselage mounted engines; (2) a low wing; (3) a T-tail type empennage; and (4) a tricycle type landing gear. A family concept is introduced to achieve structural, systems and handling quality commonality throughout. Implementing commonality can substantially reduce manufacturing and production costs. By achieving common system designs, maintenance costs can be reduced by permitting airlines to stock a smaller inventory of spares. Therefore, the higher degree of commonality, the lower the direct operating and life cycle costs. The attempt to implement some of the commonality requirements has caused configuration design problems, i.e., the twin-body concept was introduced. Design data are compared to existing aircraft, and the extent of structural, systems and handling qualities achieved are reviewed.
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Risk factors for common mental disorders in women. Population-based longitudinal study.
Patel, Vikram; Kirkwood, Betty R; Pednekar, Sulochana; Weiss, Helen; Mabey, David
2006-12-01
The determinants of common mental disorders in women have not been described in longitudinal studies from a low-income country. Population-based cohort study of 2494 women aged 18 to 50 years, in India. The Revised Clinical Interview Schedule was used for the detection of common mental disorders. There were 39 incident cases of common mental disorder in 2166 participants eligible for analysis (12-month rate 1.8%, 95% CI 1.3-2.4%). The following baseline factors were independently associated with the risk for common mental disorder: poverty (low income and having difficulty making ends meet); being married as compared with being single; use of tobacco; experiencing abnormal vaginal discharge; reporting a chronic physical illness; and having higher psychological symptom scores at baseline. Programmes to reduce the burden of common mental disorder in women should target poorer women, women with chronic physical illness and who have gynaecological symptoms, and women who use tobacco.
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A reconfigurable common spare for co-located direct television broadcasting satellites
NASA Astrophysics Data System (ADS)
Roederer, A.; Fromm, H.-H.; Berretta, G.
1984-10-01
Spare spacecraft are needed to assure continuous operation in broadcasting services provided with the aid of satellites. The present investigation is concerned with the employment of a common spare approach in which two or three countries share one or several spare spacecraft that can support or temporarily replace any of the prime satellites. Such common spares would have to be reconfigurable to adapt their antenna coverage and polarization, as well as their operating frequencies and possibly their RF output power, to the corresponding parameters assigned to the country to be served. The considered concept is discussed, taking into account questions related to system and transponder, a repointable antenna with a few feed horns, a fixed antenna (apart from fine pointing) with more feeds, and a reconfigurable broadcast payload for a common spare. A common spare for France, Germany, and Italy is considered along with a common spare for the United Kingdom and Spain.
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[Common mental disorders and self-esteem in pregnancy: prevalence and associated factors].
Silva, Ricardo Azevedo da; Ores, Liliane da Costa; Mondin, Thaíse Campos; Rizzo, Raquel Nolasco; Moraes, Inácia Gomes da Silva; Jansen, Karen; Pinheiro, Ricardo Tavares
2010-09-01
The aim of this study was to assess the prevalence of common mental disorders and the association with self-esteem and other factors in pregnant women. A nested cross-sectional study was performed in a cohort of pregnant women treated in the public health system in Pelotas, Rio Grande do Sul State, Brazil. The Self-Reporting Questionnaire (SRQ-20) was used to screen for common mental disorders and the Rosenberg's Self-Esteem Scale for self-esteem. The sample consisted of 1,267 pregnant women with a mean age of 25 years (SD = 6.53). Mean self-esteem was 9.3 points (SD = 4.76), and prevalence of common mental disorders was 41.4%. Lower self-esteem was associated with higher odds of common mental disorders (p < 0.001). There was a significant association between higher prevalence of common mental disorders and low self-esteem.
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The human motor neuron pools receive a dominant slow‐varying common synaptic input
Negro, Francesco; Yavuz, Utku Şükrü
2016-01-01
Key points Motor neurons in a pool receive both common and independent synaptic inputs, although the proportion and role of their common synaptic input is debated.Classic correlation techniques between motor unit spike trains do not measure the absolute proportion of common input and have limitations as a result of the non‐linearity of motor neurons.We propose a method that for the first time allows an accurate quantification of the absolute proportion of low frequency common synaptic input (<5 Hz) to motor neurons in humans.We applied the proposed method to three human muscles and determined experimentally that they receive a similar large amount (>60%) of common input, irrespective of their different functional and control properties.These results increase our knowledge about the role of common and independent input to motor neurons in force control. Abstract Motor neurons receive both common and independent synaptic inputs. This observation is classically based on the presence of a significant correlation between pairs of motor unit spike trains. The functional significance of different relative proportions of common input across muscles, individuals and conditions is still debated. One of the limitations in our understanding of correlated input to motor neurons is that it has not been possible so far to quantify the absolute proportion of common input with respect to the total synaptic input received by the motor neurons. Indeed, correlation measures of pairs of output spike trains only allow for relative comparisons. In the present study, we report for the first time an approach for measuring the proportion of common input in the low frequency bandwidth (<5 Hz) to a motor neuron pool in humans. This estimate is based on a phenomenological model and the theoretical fitting of the experimental values of coherence between the permutations of groups of motor unit spike trains. We demonstrate the validity of this theoretical estimate with several simulations. Moreover, we applied this method to three human muscles: the abductor digiti minimi, tibialis anterior and vastus medialis. Despite these muscles having different functional roles and control properties, as confirmed by the results of the present study, we estimate that their motor pools receive a similar and large (>60%) proportion of common low frequency oscillations with respect to their total synaptic input. These results suggest that the central nervous system provides a large amount of common input to motor neuron pools, in a similar way to that for muscles with different functional and control properties. PMID:27151459
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Yoshihara, Shigemi; Fukuda, Hironobu; Abe, Toshio; Nishida, Mitsuhiro; Yamada, Yumi; Kanno, Noriko; Arisaka, Osamu
2012-09-01
Virus infection is an important risk factor for aggravation of childhood asthma. The objective of this study was to examine the effect of drugs on aggravation of asthma induced by a common cold. Asthma control was examined in a survey of 1,014 Japanese pediatric patients with bronchial asthma. The occurrence of common cold, asthma control, and drugs used for asthma control were investigated using a modified Childhood Asthma Control Test (C-ACT) for patients aged <4 years old and 4 to 11 years old, and an Asthma Control Test (ACT) for patients aged 12 to 15 years old. The status of asthma control did not differ among the age groups. The prevalence of common cold and aggravation of asthma were significantly higher in patients aged <4 years old. Control of asthma following common cold-induced aggravation was significantly less effective in patients aged <4 years old compared to those aged ≥4 years old. In patients aged <4 years old with a common cold, asthma control was significantly more effective for those treated with leukotriene receptor antagonists (LTRAs) compared to treatment without LTRAs. Asthma control did not differ between patients who did or did not take inhaled corticosteroids or long-acting β2 stimulants. These findings showed a high prevalence of common cold in younger patients with childhood asthma and indicated that common cold can induce aggravation of asthma. LTRAs are useful for long-term asthma control in very young patients who develop an asthma attack due to a common cold.
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Hey, Jody
2010-01-01
The divergence of bonobos and three subspecies of the common chimpanzee was examined under a multipopulation isolation-with-migration (IM) model with data from 73 loci drawn from the literature. A benefit of having a full multipopulation model, relative to conducting multiple pairwise analyses between sampled populations, is that a full model can reveal historical gene flow involving ancestral populations. An example of this was found in which gene flow is indicated between the western common chimpanzee subspecies and the ancestor of the central and the eastern common chimpanzee subspecies. The results of a full analysis on all four populations are strongly consistent with analyses on pairs of populations and generally similar to results from previous studies. The basal split between bonobos and common chimpanzees was estimated at 0.93 Ma (0.68–1.54 Ma, 95% highest posterior density interval), with the split among the ancestor of three common chimpanzee populations at 0.46 Ma (0.35–0.65), and the most recent split between central and eastern common chimpanzee populations at 0.093 Ma (0.041–0.157). Population size estimates mostly fell in the range from 5,000 to 10,000 individuals. The exceptions are the size of the ancestor of the common chimpanzee and the bonobo, at 17,000 (8,000–28,000) individuals, and the central common chimpanzee and its immediate ancestor with the eastern common chimpanzee, which have effective size estimates at 27,000 (16,000–44,000) and 32,000 (19,000–54,000) individuals, respectively. PMID:19955478
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Hey, Jody
2010-04-01
The divergence of bonobos and three subspecies of the common chimpanzee was examined under a multipopulation isolation-with-migration (IM) model with data from 73 loci drawn from the literature. A benefit of having a full multipopulation model, relative to conducting multiple pairwise analyses between sampled populations, is that a full model can reveal historical gene flow involving ancestral populations. An example of this was found in which gene flow is indicated between the western common chimpanzee subspecies and the ancestor of the central and the eastern common chimpanzee subspecies. The results of a full analysis on all four populations are strongly consistent with analyses on pairs of populations and generally similar to results from previous studies. The basal split between bonobos and common chimpanzees was estimated at 0.93 Ma (0.68-1.54 Ma, 95% highest posterior density interval), with the split among the ancestor of three common chimpanzee populations at 0.46 Ma (0.35-0.65), and the most recent split between central and eastern common chimpanzee populations at 0.093 Ma (0.041-0.157). Population size estimates mostly fell in the range from 5,000 to 10,000 individuals. The exceptions are the size of the ancestor of the common chimpanzee and the bonobo, at 17,000 (8,000-28,000) individuals, and the central common chimpanzee and its immediate ancestor with the eastern common chimpanzee, which have effective size estimates at 27,000 (16,000-44,000) and 32,000 (19,000-54,000) individuals, respectively.