Sample records for common due date

  1. Single machine scheduling with slack due dates assignment

    NASA Astrophysics Data System (ADS)

    Liu, Weiguo; Hu, Xiangpei; Wang, Xuyin

    2017-04-01

    This paper considers a single machine scheduling problem in which each job is assigned an individual due date based on a common flow allowance (i.e. all jobs have slack due date). The goal is to find a sequence for jobs, together with a due date assignment, that minimizes a non-regular criterion comprising the total weighted absolute lateness value and common flow allowance cost, where the weight is a position-dependent weight. In order to solve this problem, an ? time algorithm is proposed. Some extensions of the problem are also shown.

  2. Scheduling Jobs and a Variable Maintenance on a Single Machine with Common Due-Date Assignment

    PubMed Central

    Wan, Long

    2014-01-01

    We investigate a common due-date assignment scheduling problem with a variable maintenance on a single machine. The goal is to minimize the total earliness, tardiness, and due-date cost. We derive some properties on an optimal solution for our problem. For a special case with identical jobs we propose an optimal polynomial time algorithm followed by a numerical example. PMID:25147861

  3. Heuristic methods for the single machine scheduling problem with different ready times and a common due date

    NASA Astrophysics Data System (ADS)

    Birgin, Ernesto G.; Ronconi, Débora P.

    2012-10-01

    The single machine scheduling problem with a common due date and non-identical ready times for the jobs is examined in this work. Performance is measured by the minimization of the weighted sum of earliness and tardiness penalties of the jobs. Since this problem is NP-hard, the application of constructive heuristics that exploit specific characteristics of the problem to improve their performance is investigated. The proposed approaches are examined through a computational comparative study on a set of 280 benchmark test problems with up to 1000 jobs.

  4. Collagen Fingerprinting: A New Screening Technique for Radiocarbon Dating Ancient Bone.

    PubMed

    Harvey, Virginia L; Egerton, Victoria M; Chamberlain, Andrew T; Manning, Phillip L; Buckley, Michael

    2016-01-01

    Collagen is the dominant organic component of bone and is intimately locked within the hydroxyapatite structure of this ubiquitous biomaterial that dominates archaeological and palaeontological assemblages. Radiocarbon analysis of extracted collagen is one of the most common approaches to dating bone from late Pleistocene or Holocene deposits, but dating is relatively expensive compared to other biochemical techniques. Numerous analytical methods have previously been investigated for the purpose of screening out samples that are unlikely to yield reliable dates including histological analysis, UV-stimulated fluorescence and, most commonly, the measurement of percentage nitrogen (%N) and ratio of carbon to nitrogen (C:N). Here we propose the use of collagen fingerprinting (also known as Zooarchaeology by Mass Spectrometry, or ZooMS, when applied to species identification) as an alternative screening method for radiocarbon dating, due to its ability to provide information on collagen presence and quality, alongside species identification. The method was tested on a series of sub-fossil bone specimens from cave systems on Cayman Brac (Cayman Islands), chosen due to the observable range in diagenetic alteration, and in particular, the extent of mineralisation. Six (14)C dates, of 18 initial attempts, were obtained from remains of extinct hutia, Capromys sp. (Rodentia; Capromyidae), recovered from five distinct caves on Cayman Brac, and ranging from 393 ± 25 to 1588 ± 26 radiocarbon years before present (yr BP). All of the bone samples that yielded radiocarbon dates generated excellent collagen fingerprints, and conversely those that gave poor fingerprints also failed dating. Additionally, two successfully fingerprinted bone samples were screened out from a set of 81. Both subsequently generated (14)C dates, demonstrating successful utilisation of ZooMS as an alternative screening mechanism to identify bone samples that are suitable for 1(4)C analysis.

  5. Collagen Fingerprinting: A New Screening Technique for Radiocarbon Dating Ancient Bone

    PubMed Central

    Harvey, Virginia L.; Egerton, Victoria M.; Chamberlain, Andrew T.; Manning, Phillip L.; Buckley, Michael

    2016-01-01

    Collagen is the dominant organic component of bone and is intimately locked within the hydroxyapatite structure of this ubiquitous biomaterial that dominates archaeological and palaeontological assemblages. Radiocarbon analysis of extracted collagen is one of the most common approaches to dating bone from late Pleistocene or Holocene deposits, but dating is relatively expensive compared to other biochemical techniques. Numerous analytical methods have previously been investigated for the purpose of screening out samples that are unlikely to yield reliable dates including histological analysis, UV-stimulated fluorescence and, most commonly, the measurement of percentage nitrogen (%N) and ratio of carbon to nitrogen (C:N). Here we propose the use of collagen fingerprinting (also known as Zooarchaeology by Mass Spectrometry, or ZooMS, when applied to species identification) as an alternative screening method for radiocarbon dating, due to its ability to provide information on collagen presence and quality, alongside species identification. The method was tested on a series of sub-fossil bone specimens from cave systems on Cayman Brac (Cayman Islands), chosen due to the observable range in diagenetic alteration, and in particular, the extent of mineralisation. Six 14C dates, of 18 initial attempts, were obtained from remains of extinct hutia, Capromys sp. (Rodentia; Capromyidae), recovered from five distinct caves on Cayman Brac, and ranging from 393 ± 25 to 1588 ± 26 radiocarbon years before present (yr BP). All of the bone samples that yielded radiocarbon dates generated excellent collagen fingerprints, and conversely those that gave poor fingerprints also failed dating. Additionally, two successfully fingerprinted bone samples were screened out from a set of 81. Both subsequently generated 14C dates, demonstrating successful utilisation of ZooMS as an alternative screening mechanism to identify bone samples that are suitable for 14C analysis. PMID:26938469

  6. Command and Control Options for Joint Logistics

    DTIC Science & Technology

    2011-03-24

    PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) 24-03-2011 2. REPORT TYPE Strategy Research Project 3. DATES...point due to excessive government spending.6 The result will most-assuredly be a tightening of pocketbooks , a call for efficiencies and a smaller...procedures and capabilities of Service component logistics processes to build the logistics common operating picture and associated actions. 8. Integrated

  7. Intra-grain Common Pb Correction and Detrital Apatite U-Pb Dating via LA-ICPMS Depth Profiling

    NASA Astrophysics Data System (ADS)

    Boyd, P. D.; Galster, F.; Stockli, D. F.

    2017-12-01

    Apatite is a common accessory phase in igneous and sedimentary rocks. While apatite is widely employed as a low-temperature thermochronometric tool, it has been increasingly utilized to constrain moderate temperature cooling histories by U-Pb dating. Apatite U-Pb is characterized by a thermal sensitivity window of 375-550°C. This unique temperature window recorded by the apatite U-Pb system, and the near-ubiquitous presence of apatite in igneous and clastic sedimentary rocks makes it a powerful tool able to illuminate mid-crustal tectono-thermal processes. However, as apatite incorporates only modest amounts of U and Th (1-10s of ppm) the significant amounts of non-radiogenic "common" Pb incorporated during its formation presents a major hurdle for apatite U-Pb dating. In bedrock samples common Pb in apatite can be corrected for by the measurement of Pb in a cogenetic mineral phase, such as feldspar, that does not incorporate U or from determination of a common Pb composition from multiple analyses in Tera-Wasserburg space. While these methods for common Pb correction in apatite can work for igneous samples, they cannot be applied to detrital apatite in sedimentary rocks with variable common Pb compositions. The obstacle of common Pb in apatite has hindered the application of detrital apatite U-Pb dating in provenance studies, despite the fact that it would be a powerful tool. This study presents a new method for the in situ correction of common Pb in apatite through the utilization of novel LA-ICP-MS depth profiling, which can recover U-Pb ratios at micron-scale spatial resolution during ablation of a grain. Due to the intra-grain U variability in apatite, a mixing line for a single grain can be generated in Tera-Wasserburg Concordia space. As a case study, apatite from a Variscan alpine granite were analyzed using both the single and multi-grain method, with both methods giving identical results. As a second case study the intra-grain method was then performed on detrital apatite from the Swiss Northern Alpine Foreland Basin, where the common Pb composition and age spectra of detrital apatite grains were elucidated. The novel intra-grain apatite method enables the correction for common Pb in detrital apatite, making it feasible to incorporate detrital apatite U-Pb dating in provenance and source-to-sink studies.

  8. New Robust Reference Materials for In Situ Single Grain Rutile U-Pb Geochronology and Method Refinements for Detrital Rutile Analysis by LA-MC-ICP-MS

    NASA Astrophysics Data System (ADS)

    Parrish, R. R.; Bracciali, L.; Condon, D. J.; Horstwood, M. S.; Najman, Y.

    2012-12-01

    While rutile (TiO2) occurs in the heavy mineral suite of detrital sediments and originates mainly in medium- to high-grade metamorphic and some igneous rocks, there are very few applications of U-Pb dating of rutile to provenance studies; this is due to an overreliance on zircon, low U content of rutile limiting measurement quality by in situ methods, a higher proportion of common Pb relative to zircon, and a lack of widely available good quality reference materials. We have addressed these issues and characterized two ~ 1.8 Ga rutile reference materials by SEM, trace elements, U-Pb ID-TIMS, and intra-grain and inter-grain U-Pb LA-MC-ICP-MS analysis using mixed faraday and multiple ion counting detectors with high sensitivity. We have assessed U-Pb discordance and in situ variations in relative common Pb and age and their bearing on the quality of the reference materials for in situ U-Pb dating. The rutiles (Sugluk-4 and PCA-S207) come from granulite facies belts of the Canadian Shield, namely the northern Cape Smith Belt of Quebec and the Snowbird Tectonic Zone (Sasatchewan). The ID-TIMS data are slightly discordant due to variable common Pb and limited Pb loss; the variation in 6 single grains of Sugluk-4, that we use as the primary reference material, is <1% in 206Pb/238U, and <2% for 207Pb/206Pb (95 % conf.); after common Pb correction these variations are <1%. The measured variations are smaller than in existing reference materials (i.e. R10) in current use. LA-ICP-MC-MS data (n ~ 500 for each) have a reproducibility of 206Pb/238U and 207Pb/206Pb of ~2-4% (at the 2S level), which is only modestly worse than long-term data for multiple zircon standards, this being due to the real variation in measured values arising from limited Pb loss, age variation, and common Pb variability [1]. We have applied our refined method to the provenance of rutile from drainages from British Columbia, Bhutan, and the Brahmaputra River of NE India (predominant rutile ages ~ 50, 15, and 2 Ma, respectively; Bracciali et al., this meeting). Our method successfully dates >75% of all rutile grains in a sediment; unsuccessful analyses are due to poor quality rutiles with massive common Pb and/or U contents < ~1ppm. While some analyses are therefore unusable, unlike zircon age zoning is rare to absent in rutile and there is little need to image grains to identify 'inheritance' to arrive at a correct interpretation of measured ages. Rutile has a ~ 500°C closure temperature and thus records mainly the time of cooling; it is therefore a sensitive recorder of metamorphic thermochronological information, and an excellent complement to detrital zircon analysis. There appears to be huge scope of in situ application of U-Pb dating to detrital rutile in provenance studies in the future. [1] Bracciali L., Parrish R.R., Condon D., Horstwood M.S.A., Najman,Y., Two new rutile reference materials for in situ U-Pb LA-MC-ICP-MS dating and applications to sedimentary provenance, submitted to Chem. Geol.

  9. Snežna jama (Slovenia): Interdisciplinary dating of cave sediments and implication for landscape evolution

    PubMed Central

    Häuselmann, Philipp; Mihevc, Andrej; Pruner, Petr; Horáček, Ivan; Čermák, Stanislav; Hercman, Helena; Sahy, Diana; Fiebig, Markus; Hajna, Nadja Zupan; Bosák, Pavel

    2015-01-01

    Caves are important markers of surface evolution, since they are, as a general rule, linked with ancient valley bottoms by their springs. However, caves can only be dated indirectly by means of the sediments they contain. If the sediment is older than common dating methods, one has to use multiple dating approaches in order to get meaningful results. U/Th dating, palaeomagnetic analysis of flowstone and sediment profiles, cosmogenic dating of quartz pebbles, and mammalian dating allowed a robust estimate of speleogenesis, sediment deposition, climatic change at the surface, and uplift history on the Periadriatic fault line during the Plio-Pleistocene. Our dates indicate that Snežna jama was formed in the (Upper) Miocene, received its sedimentary deposits during the Pliocene in a rather low-lying, hilly landscape, and became inactive due to uplift along the Periadriatic and Sava faults and climatic changes at the beginning of the Quaternary. Although it is only a single cave, the information contained within it makes it an important site of the Southern Alps. PMID:26516294

  10. Snežna jama (Slovenia): Interdisciplinary dating of cave sediments and implication for landscape evolution.

    PubMed

    Häuselmann, Philipp; Mihevc, Andrej; Pruner, Petr; Horáček, Ivan; Čermák, Stanislav; Hercman, Helena; Sahy, Diana; Fiebig, Markus; Hajna, Nadja Zupan; Bosák, Pavel

    2015-10-15

    Caves are important markers of surface evolution, since they are, as a general rule, linked with ancient valley bottoms by their springs. However, caves can only be dated indirectly by means of the sediments they contain. If the sediment is older than common dating methods, one has to use multiple dating approaches in order to get meaningful results. U/Th dating, palaeomagnetic analysis of flowstone and sediment profiles, cosmogenic dating of quartz pebbles, and mammalian dating allowed a robust estimate of speleogenesis, sediment deposition, climatic change at the surface, and uplift history on the Periadriatic fault line during the Plio-Pleistocene. Our dates indicate that Snežna jama was formed in the (Upper) Miocene, received its sedimentary deposits during the Pliocene in a rather low-lying, hilly landscape, and became inactive due to uplift along the Periadriatic and Sava faults and climatic changes at the beginning of the Quaternary. Although it is only a single cave, the information contained within it makes it an important site of the Southern Alps.

  11. Identification and characterization of gene-based SSR markers in date palm (Phoenix dactylifera L.).

    PubMed

    Zhao, Yongli; Williams, Roxanne; Prakash, C S; He, Guohao

    2012-12-15

    Date palm (Phoenix dactylifera L.) is an important tree in the Middle East and North Africa due to the nutritional value of its fruit. Molecular Breeding would accelerate genetic improvement of fruit tree through marker assisted selection. However, the lack of molecular markers in date palm restricts the application of molecular breeding. In this study, we analyzed 28,889 EST sequences from the date palm genome database to identify simple-sequence repeats (SSRs) and to develop gene-based markers, i.e. expressed sequence tag-SSRs (EST-SSRs). We identified 4,609 ESTs as containing SSRs, among which, trinucleotide motifs (69.7%) were the most common, followed by tetranucleotide (10.4%) and dinucleotide motifs (9.6%). The motif AG (85.7%) was most abundant in dinucleotides, while motifs AGG (26.8%), AAG (19.3%), and AGC (16.1%) were most common among trinucleotides. A total of 4,967 primer pairs were designed for EST-SSR markers from the computational data. In a follow up laboratory study, we tested a sample of 20 random selected primer pairs for amplification and polymorphism detection using genomic DNA from date palm cultivars. Nearly one-third of these primer pairs detected DNA polymorphism to differentiate the twelve date palm cultivars used. Functional categorization of EST sequences containing SSRs revealed that 3,108 (67.4%) of such ESTs had homology with known proteins. Date palm EST sequences exhibits a good resource for developing gene-based markers. These genic markers identified in our study may provide a valuable genetic and genomic tool for further genetic research and varietal development in date palm, such as diversity study, QTL mapping, and molecular breeding.

  12. Direct dating of Pleistocene stegodon from Timor Island, East Nusa Tenggara.

    PubMed

    Louys, Julien; Price, Gilbert J; O'Connor, Sue

    2016-01-01

    Stegodons are a commonly recovered extinct proboscidean (elephants and allies) from the Pleistocene record of Southeast Asian oceanic islands. Estimates on when stegodons arrived on individual islands and the timings of their extinctions are poorly constrained due to few reported direct geochronological analyses of their remains. Here we report on uranium-series dating of a stegodon tusk recovered from the Ainaro Gravels of Timor. The six dates obtained indicate the local presence of stegodons in Timor at or before 130 ka, significantly pre-dating the earliest evidence of humans on the island. On the basis of current data, we find no evidence for significant environmental changes or the presence of modern humans in the region during that time. Thus, we do not consider either of these factors to have contributed significantly to their extinction. In the absence of these, we propose that their extinction was possibly the result of long-term demographic and genetic declines associated with an isolated island population.

  13. Common Postmortem Computed Tomography Findings Following Atraumatic Death: Differentiation between Normal Postmortem Changes and Pathologic Lesions

    PubMed Central

    Gonoi, Wataru; Okuma, Hidemi; Shirota, Go; Shintani, Yukako; Abe, Hiroyuki; Takazawa, Yutaka; Fukayama, Masashi; Ohtomo, Kuni

    2015-01-01

    Computed tomography (CT) is widely used in postmortem investigations as an adjunct to the traditional autopsy in forensic medicine. To date, several studies have described postmortem CT findings as being caused by normal postmortem changes. However, on interpretation, postmortem CT findings that are seemingly due to normal postmortem changes initially, may not have been mere postmortem artifacts. In this pictorial essay, we describe the common postmortem CT findings in cases of atraumatic in-hospital death and describe the diagnostic pitfalls of normal postmortem changes that can mimic real pathologic lesions. PMID:26175579

  14. Dating Last Interglacial Coastal Systems Using New Feldspar Luminescence Technologies

    NASA Astrophysics Data System (ADS)

    Lamothe, M.

    2017-12-01

    The recent explosion in new luminescence dating technologies offers new opportunities to explore Quaternary marine coastal facies and landforms. However, tectonic and climatic processes controlling the development of Pleistocene coastal lithosomes are commonly obscured by their poorly constrained geological age. Luminescence dating of feldspar probes one order of magnitude deeper into geological time than radiocarbon and more than 5 times the current age range of quartz optically-stimulated luminescence, routinely used in luminescence dating. However, feldspar luminescence stimulated by infrared photons (eg IRSL) is hampered by anomalous fading. Successful correction methods developed by us over the last 15 years did produce sound chronologies but the fading-corrected ages carried large uncertainties. New approaches initiated by other laboratories, mainly in Europe, have isolated high temperature post-IRSL luminescence as this signal seems to be only slightly affected by fading. However, the gain in stability seems to be lessened due to bleachibility issues, generating age overestimations. We developed a novel protocol known as post-isothermal IRSL dating (Pit-IR) that focuses on a dual system of luminescence signals, probing low (50C) and medium (225C) temperature IRSL signals following isothermal treatments of various intensities. These protocols have been tested on Last interglacial coastal sediments in strikingly different GIA contexts along the Atlantic coastal areas of SE USA as well as from Morocco, Brazil and LIG sites in the Mediterranean basin. A systematic analysis of these results would suggest that a) falling-stages sequences are more commonly preserved as the OSL/IRSL ages are preferentially dating from the end of the MIS5e high stand and b) MIS5a marine sediments may be detectable away from areas generally thought to be affected by peripheral bulge collapse.

  15. Materialistic Desires or Childhood Adversities as Explanations for Girls' Trading Sex for Benefits.

    PubMed

    Song, Juyoung; Morash, Merry

    2016-01-01

    This study investigates whether high school and younger South Korean girls trade sex with middle-aged men for benefits due to cultural emphasis on materialism/consumerism, childhood adversities, or both. This form of prostitution, referred to as "compensated dating," is common in economically developed East Asian Countries, where there is debate about its causes. Purposeful sampling was used to select a diverse group of 25 girls who described involvement in compensated dating, and a life calendar method was used to guide the interview. The rich data were subjected to thematic analysis to show the nature of prostitution involvement, precursors, and motivations. Data analysis revealed that sole reliance on materialistic desire as an explanation of prostitution obscures the influence of peer pressure and family dysfunction. Findings suggest the need for social services rather than punitive responses to girls involved in compensated dating. © The Author(s) 2014.

  16. When you pass your due date

    MedlinePlus

    ... correctly. After all, a due date is not exact, but an estimate. Your due date is estimated ... in pregnancy. However: Many women cannot remember the exact day of their last period, which makes it ...

  17. 47 CFR 64.1604 - Effective date.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Effective date. 64.1604 Section 64.1604 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) MISCELLANEOUS RULES RELATING TO COMMON CARRIERS Calling Party Telephone Number; Privacy § 64.1604 Effective date. The...

  18. Gastrointestinal Side Effects of Antiarrhythmic Medications: A Review of Current Literature.

    PubMed

    Amjad, Waseem; Qureshi, Waqas; Farooq, Ali; Sohail, Umair; Khatoon, Salma; Pervaiz, Sarah; Narra, Pratyusha; Hasan, Syeda M; Ali, Farman; Ullah, Aman; Guttmann, Steven

    2017-09-03

    Antiarrhythmic drugs are commonly prescribed cardiac drugs. Due to their receptor mimicry with several of the gastrointestinal tract receptors, they can frequently lead to gastrointestinal side effects. These side effects are the most common reasons for discontinuation of these drugs by the patients. Knowledge of these side effects is important for clinicians that manage antiarrhythmic drugs. This review focuses on the gastrointestinal side effects of these drugs and provides a detailed up-to-date literature review of the side effects of these drugs. The review provides case reports reported in the literature as well as possible mechanisms that lead to gastrointestinal side effects.

  19. Capability of U-Pb dating of zircons from Quaternary tephra: Jemez Mountains, NM, and La Sal Mountains, UT, USA

    NASA Astrophysics Data System (ADS)

    Krautz, Jana; Hofmann, Mandy; Gärtner, Andreas; Linnemann, Ulf; Kleber, Arno

    2018-01-01

    Two Quaternary tephras derived from the Jemez Mountains, New Mexico - the Guaje and Tsankawi tephras - are difficult to distinguish due to their similar glass-shard chemical composition. Differences in bulk chemical composition are small as well. Here we examine the feasibility to assign an age to a distal tephra layer in the La Sal Mountains, Utah, by U-Pb dating of zircons and to correlate it with one of the two Jemez eruptions. We also dated original Jemez tephras for comparison. Even though the tephras are very young, we obtained reasonable age determinations using the youngest cluster of zircon grains overlapping in age at 2σ. Thereafter, the Guaje tephra is 1.513 ± 0.021 Myr old. The La Sal Mountains tephra is correlated with the Tsankawi tephra. Three samples yielded a common age range of 1.31-1.40 Myr. All ages are in slight disagreement with published age determinations obtained by 40Ar / 39Ar dating. These findings indicate that distal Jemez tephras can be distinguished by U-Pb dating. Furthermore, we encourage giving this method a try for age assignments even of Quaternary volcanic material.

  20. 43 CFR 4.905 - What if a due date falls on a day the Department or relevant office is not open for business?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false What if a due date falls on a day the... Appeals Concerning Federal Oil and Gas Royalties and Related Matters § 4.905 What if a due date falls on a day the Department or relevant office is not open for business? If a due date under this subpart falls...

  1. 43 CFR 4.905 - What if a due date falls on a day the Department or relevant office is not open for business?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false What if a due date falls on a day the... Appeals Concerning Federal Oil and Gas Royalties and Related Matters § 4.905 What if a due date falls on a day the Department or relevant office is not open for business? If a due date under this subpart falls...

  2. 43 CFR 4.905 - What if a due date falls on a day the Department or relevant office is not open for business?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 1 2011-10-01 2011-10-01 false What if a due date falls on a day the... Appeals Concerning Federal Oil and Gas Royalties and Related Matters § 4.905 What if a due date falls on a day the Department or relevant office is not open for business? If a due date under this subpart falls...

  3. 43 CFR 4.905 - What if a due date falls on a day the Department or relevant office is not open for business?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false What if a due date falls on a day the... Appeals Concerning Federal Oil and Gas Royalties and Related Matters § 4.905 What if a due date falls on a day the Department or relevant office is not open for business? If a due date under this subpart falls...

  4. 43 CFR 4.905 - What if a due date falls on a day the Department or relevant office is not open for business?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 1 2012-10-01 2011-10-01 true What if a due date falls on a day the... Appeals Concerning Federal Oil and Gas Royalties and Related Matters § 4.905 What if a due date falls on a day the Department or relevant office is not open for business? If a due date under this subpart falls...

  5. A recent review on phytochemical constituents and medicinal properties of kesum (Polygonum minus Huds.)

    PubMed Central

    Vikram, Paritala; Chiruvella, Kishore Kumar; Ripain, Ilfah Husna Abdullah; Arifullah, Mohammed

    2014-01-01

    Medicinal plants and herbal preparations are gaining renowned interest in scientific communities nowadays due to their reliable pharmacological actions and affordability to common people which makes them effective in control of various diseases. Polygonum minus (Polygonaceae) locally known as kesum is an aromatic plant commonly used in Malay delicacies. The plant is having potential applications due to its high volatile oil constituents in perfumes and powerful antioxidant activity. It has been used traditionally to treat various ailments including dandruff. The research has been carried out by various researchers using different in vitro and in vivo models for biological evaluations to support these claims. This review paper may help upcoming research activities on Polygonum minus by giving up to date information on the phytochemical constituents and medicinal properties of kesum to a possible extent with relevant data. PMID:25182942

  6. 40 CFR Table 1 to Subpart B of... - Section 112(j) Part 2 Application Due Dates

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CATEGORIES Requirements for Control Technology Determinations for Major Sources in Accordance With Clean Air...—Section 112(j) Part 2 Application Due Dates Due date MACT standard 10/30/03 Combustion Turbines.Lime...

  7. 40 CFR Table 1 to Subpart B of... - Section 112(j) Part 2 Application Due Dates

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... CATEGORIES Requirements for Control Technology Determinations for Major Sources in Accordance With Clean Air...—Section 112(j) Part 2 Application Due Dates Due date MACT standard 10/30/03 Combustion Turbines.Lime...

  8. 40 CFR Table 1 to Subpart B of... - Section 112(j) Part 2 Application Due Dates

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... CATEGORIES Requirements for Control Technology Determinations for Major Sources in Accordance With Clean Air...—Section 112(j) Part 2 Application Due Dates Due date MACT standard 10/30/03 Combustion Turbines.Lime...

  9. 40 CFR Table 1 to Subpart B of... - Section 112(j) Part 2 Application Due Dates

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... CATEGORIES Requirements for Control Technology Determinations for Major Sources in Accordance With Clean Air...—Section 112(j) Part 2 Application Due Dates Due date MACT standard 10/30/03 Combustion Turbines.Lime...

  10. Genome-wide expression profiling in leaves and roots of date palm (Phoenix dactylifera L.) exposed to salinity.

    PubMed

    Yaish, Mahmoud W; Patankar, Himanshu V; Assaha, Dekoum V M; Zheng, Yun; Al-Yahyai, Rashid; Sunkar, Ramanjulu

    2017-03-22

    Date palm, as one of the most important fruit crops in North African and West Asian countries including Oman, is facing serious growth problems due to salinity, arising from persistent use of saline water for irrigation. Although date palm is a relatively salt-tolerant plant species, its adaptive mechanisms to salt stress are largely unknown. In order to get an insight into molecular mechanisms of salt tolerance, RNA was profiled in leaves and roots of date palm seedlings subjected to NaCl for 10 days. Under salt stress, photosynthetic parameters were differentially affected; all gas exchange parameters were decreased but the quantum yield of PSII was unaffected while non-photochemical quenching was increased. Analyses of gene expression profiles revealed 2630 and 4687 genes were differentially expressed in leaves and roots, respectively, under salt stress. Of these, 194 genes were identified as commonly responding in both the tissue sources. Gene ontology (GO) analysis in leaves revealed enrichment of transcripts involved in metabolic pathways including photosynthesis, sucrose and starch metabolism, and oxidative phosphorylation, while in roots genes involved in membrane transport, phenylpropanoid biosynthesis, purine, thiamine, and tryptophan metabolism, and casparian strip development were enriched. Differentially expressed genes (DEGs) common to both tissues included the auxin responsive gene, GH3, a putative potassium transporter 8 and vacuolar membrane proton pump. Leaf and root tissues respond differentially to salinity stress and this study has revealed genes and pathways that are associated with responses to elevated NaCl levels and thus may play important roles in salt tolerance providing a foundation for functional characterization of salt stress-responsive genes in the date palm.

  11. Developmental Associations Between Adolescent Alcohol Use and Dating Aggression

    PubMed Central

    Reyes, H. Luz McNaughton; Foshee, Vangie A.; Bauer, Daniel J.; Ennett, Susan T.

    2012-01-01

    While numerous studies have established a link between alcohol use and partner violence in adulthood, little research has examined this relation during adolescence. The current study used multivariate growth models to examine relations between alcohol use and dating aggression across grades 8 through 12 controlling for shared risk factors (common causes) that predict both behaviors. Associations between trajectories of alcohol use and dating aggression were reduced substantially when common causes were controlled. Concurrent associations between the two behaviors were significant across nearly all grades but no evidence was found for prospective connections from prior alcohol use to subsequent dating aggression or vice versa. Findings suggest that prevention efforts should target common causes of alcohol use and dating aggression. PMID:23589667

  12. 45 CFR 304.25 - Treatment of expenditures; due date.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Treatment of expenditures; due date. 304.25 Section 304.25 Public Welfare Regulations Relating to Public Welfare OFFICE OF CHILD SUPPORT ENFORCEMENT... HUMAN SERVICES FEDERAL FINANCIAL PARTICIPATION § 304.25 Treatment of expenditures; due date. (a...

  13. 48 CFR 32.904 - Determining payment due dates.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... is subject to contract settlement actions (e.g., release of claims), acceptance is deemed to occur on...) Construction contracts. (1) The due date for making payments on construction contracts is as follows: (i) The... by the clause at 52.232-5, Payments Under Fixed-Price Construction Contracts. (ii) The due date for...

  14. Ion Channels in Glioblastoma

    PubMed Central

    Molenaar, Remco J.

    2011-01-01

    Glioblastoma is the most common primary brain tumor with the most dismal prognosis. It is characterized by extensive invasion, migration, and angiogenesis. Median survival is only 15 months due to this behavior, rendering focal surgical resection ineffective and adequate radiotherapy impossible. At this moment, several ion channels have been implicated in glioblastoma proliferation, migration, and invasion. This paper summarizes studies on potassium, sodium, chloride, and calcium channels of glioblastoma. It provides an up-to-date overview of the literature that could ultimately lead to new therapeutic targets. PMID:22389824

  15. Ion channels in glioblastoma.

    PubMed

    Molenaar, Remco J

    2011-01-01

    Glioblastoma is the most common primary brain tumor with the most dismal prognosis. It is characterized by extensive invasion, migration, and angiogenesis. Median survival is only 15 months due to this behavior, rendering focal surgical resection ineffective and adequate radiotherapy impossible. At this moment, several ion channels have been implicated in glioblastoma proliferation, migration, and invasion. This paper summarizes studies on potassium, sodium, chloride, and calcium channels of glioblastoma. It provides an up-to-date overview of the literature that could ultimately lead to new therapeutic targets.

  16. Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection.

    PubMed

    Ruiz, Joaquim

    2003-05-01

    Quinolones are broad-spectrum antibacterial agents, commonly used in both clinical and veterinary medicine. Their extensive use has resulted in bacteria rapidly developing resistance to these agents. Two mechanisms of quinolone resistance have been established to date: alterations in the targets of quinolones, and decreased accumulation due to impermeability of the membrane and/or an overexpression of efflux pump systems. Recently, mobile elements have also been described, carrying the qnr gene, which confers resistance to quinolones.

  17. Comparative study of neuropharmacological, analgesic properties and phenolic profile of Ajwah, Safawy and Sukkari cultivars of date palm (Phoenix dactylifera).

    PubMed

    Sheikh, Bassem Yousef; Zihad, S M Neamul Kabir; Sifat, Nazifa; Uddin, Shaikh J; Shilpi, Jamil A; Hamdi, Omer A A; Hossain, Hemayet; Rouf, Razina; Jahan, Ismet Ara

    2016-01-01

    In addition to the rich nutritional value, date palm is also used in various ethnobotanical practices for the treatment of various disease conditions. Present investigation was undertaken to examine the neuropharmacological and antinociceptive effect of the ethanol extract of three date cultivars growing in Saudi Arabia, namely Ajwah, Safawy and Sukkari. Neuropharmacological effect was observed by pentobarbitone induced sleeping time, open field, and hole board test. Antinociceptive activity was tested by acetic acid induced writhing and hot plate test. The date extracts were also subjected to HPLC analysis to detect the presence of common bioactive polyphenols. All the three date extracts extended the pentobarbitone induced sleeping time, reduced locomotor activity in open field test and reduced exploratory behaviour in hole board test in mice. The extracts also reduced acetic acid induced writhing and delayed response time in hot plate test. The activities were stronger for Ajwah than the other two date cultivars. HPLC analysis indicated the presence of trans -ferulic acid in all three cultivars, while (+)-catechin and (-)-epicatechin only in Ajwah and Safawy. The observed neuropharmacological and analgesic activity could be partly due to the presence of (+)-catechin, (-)-epicatechin and trans -ferulic acid, three important plant polyphenols well known for their neuroprotective activity and their ability to exert antioxidant activity on brain cells. Present investigation also supports the ethnobotanical use of date palm to provide ameliorating effects in pain and CNS disorders.

  18. Genital herpes.

    PubMed

    Garland, Suzanne M; Steben, Marc

    2014-10-01

    Genital herpes is a relatively common infection caused by herpes simplex virus (HSV) type one or two (HSV-1, HSV-2) respectively. It is acquired most commonly via sexual activity. More recently there has been an increase in infections due to HSV-1. Most new cases of genital HSV are not diagnosed due to HSV infections having short-lived signs and symptoms, or in many instances are asymptomatic. Hence many people infected with HSV are unaware that they have it. The risk of transmission to a partner is highest during outbreak periods, when there are visible lesions, although genital HSV can also be transmitted during asymptomatic periods. Use of condoms and antiviral medications assist in preventing transmission. Antiviral agents are effective in controlling clinical episodes, but do not eradicate infection, which remains latent for the life of a patient. Despite the surge in vaccine research, there is unfortunately no readily available preventative or therapeutic vaccine for HSV to date. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

  19. Ethnoveterinary health management practices using medicinal plants in South Asia - a review.

    PubMed

    Suroowan, Shanoo; Javeed, Faisal; Ahmad, Mushtaq; Zafar, Muhammad; Noor, Mehwish Jamil; Kayani, Sadaf; Javed, Ali; Mahomoodally, Mohamad Fawzi

    2017-06-01

    Animal rearing is the major occupation of most population of South Asian countries. Due to lack of resources and limited approach to modern medicine, most of the livestock raisers prefer to use plant-based traditional medicine also referred to as ethnoveterinary medicine (EVM). Indeed, the use of medicinal plants in South Asia dates back to several centuries with documented evidences. However, there is currently a dearth of documentation and compilation of use of medicinal plants for animal diseases in this part of the world. This review aims to provide an up-to-date compilation of common medicinal plants used for the treatment and/or management of common animal diseases in South Asian countries. Extensive literature search was conducted online and relevant data was retrieved from well-known scientific databases. A total of 276 plants belonging to 95 families have been documented to be in common use for managing 14 different categories of animal diseases. Solanaceae, Lamiaceae, Fabaceae, and Leguminosae were most common plant families in terms of their plant species used for EVM. Gastric diseases were commonly reported and accounted for 72 species of plants used for its treatment followed by the miscellaneous disorders category and skin diseases comprising of 65 and 39 plant species respectively. Herbs accounted for 46% of the total plant species, followed by trees (33%), and shrubs (18%). The EVM were applied through different routes of administration; oral administration accounted for 72% followed by topical application 27%, while burning of plant parts to create smoke around animals to repel insects was less common (1%). It is anticipated that the present review will stimulate further ethnoveterinary research among livestock disease management practices in South Asia.

  20. 78 FR 33690 - Common Crop Insurance Regulations; Pecan Crop Insurance Provisions; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ...-0008] RIN 0563-AC35 Common Crop Insurance Regulations; Pecan Crop Insurance Provisions; Correction... FR 13454-13460). The regulation pertains to the insurance of Pecans. DATES: Effective Date: June 5...: [[Page 33691

  1. Epidemiology and patterns of facial fractures due to road traffic accidents in Taiwan: A 15-year retrospective study.

    PubMed

    Yang, Cheng-San; Chen, Solomon Chih-Cheng; Yang, Yung-Cheng; Huang, Li-Chung; Guo, How-Ran; Yang, Hsin-Yi

    2017-10-03

    The facial region is a commonly fractured site, but the etiology varies widely by country and geographic region. To date, there are no population-based studies of facial fractures in Taiwan. We conducted a retrospective study of patients diagnosed with facial fracture and registered in the National Health Insurance Research Database of Taiwan between 1997 and 2011. The epidemiological characteristics of this cohort were analyzed, including the etiology, fracture site, associated injuries, and sex and age distributions. A total of 6,013 cases were identified that involved facial fractures. Most patients were male (69.8%), aged 18-29 years (35.8%), and had fractures caused by road traffic accidents (RTAs; 55.2%), particularly motorcycle accidents (31.5%). Falls increased in frequency with advancing age, reaching 23.9% among the elderly (age > 65 years). The most common sites of involvement were the malar and maxillary bones (54.0%), but nasal bone fractures were more common among those younger than 18 years. Most facial injuries in Taiwan occur in young males and typically result from RTAs, particularly involving motorcycles. However, with increasing age, there is an increase in the proportion of facial injuries due to falls.

  2. Date Palm (Phoenix dactylifera) Fruits as a Potential Cardioprotective Agent: The Role of Circulating Progenitor Cells

    PubMed Central

    Alhaider, Ibrahim A.; Mohamed, Maged E.; Ahmed, K. K. M.; Kumar, Arun H. S.

    2017-01-01

    Context: Date palms, along with their fruits’ dietary consumption, possess enormous medicinal and pharmacological activities manifested in their usage in a variety of ailments in the various traditional systems of medicine. In recent years, the identification of progenitor cells in the adult organ systems has opened an altogether new approach to therapeutics, due to the ability of these cells to repair the damaged cells/tissues. Hence, the concept of developing therapeutics, which can mobilize endogenous progenitor cells, following tissue injury, to enhance tissue repair process is clinically relevant. Objectives: The present study investigates the potential of date of palm fruit extracts in repairing tissue injury following myocardial infarction (MI) potentially by mobilizing circulating progenitor cells. Methods: Extracts of four different varieties of date palm fruits common in Saudi Arabia eastern provision were scrutinized for their total flavonoid, total phenolic, in vitro antioxidant capacity, as well as their effects on two different rodent MI models. Results: High concentrations of phenolic and flavonoid compounds were observed in date palm fruit extracts, which contributed to the promising antioxidant activities of these extracts and the observed high protective effect against various induced in vivo MI. The extracts showed ability to build up reserves and to mobilize circulating progenitor cells from bone marrow and peripheral circulation to the site of myocardial infraction. Conclusion: Date palm fruit extracts have the potential to mobilize endogenous circulating progenitor cells, which can promote tissue repair following ischemic injury. PMID:28928656

  3. Date Palm (Phoenix dactylifera) Fruits as a Potential Cardioprotective Agent: The Role of Circulating Progenitor Cells.

    PubMed

    Alhaider, Ibrahim A; Mohamed, Maged E; Ahmed, K K M; Kumar, Arun H S

    2017-01-01

    Context: Date palms, along with their fruits' dietary consumption, possess enormous medicinal and pharmacological activities manifested in their usage in a variety of ailments in the various traditional systems of medicine. In recent years, the identification of progenitor cells in the adult organ systems has opened an altogether new approach to therapeutics, due to the ability of these cells to repair the damaged cells/tissues. Hence, the concept of developing therapeutics, which can mobilize endogenous progenitor cells, following tissue injury, to enhance tissue repair process is clinically relevant. Objectives: The present study investigates the potential of date of palm fruit extracts in repairing tissue injury following myocardial infarction (MI) potentially by mobilizing circulating progenitor cells. Methods: Extracts of four different varieties of date palm fruits common in Saudi Arabia eastern provision were scrutinized for their total flavonoid, total phenolic, in vitro antioxidant capacity, as well as their effects on two different rodent MI models. Results: High concentrations of phenolic and flavonoid compounds were observed in date palm fruit extracts, which contributed to the promising antioxidant activities of these extracts and the observed high protective effect against various induced in vivo MI. The extracts showed ability to build up reserves and to mobilize circulating progenitor cells from bone marrow and peripheral circulation to the site of myocardial infraction. Conclusion: Date palm fruit extracts have the potential to mobilize endogenous circulating progenitor cells, which can promote tissue repair following ischemic injury.

  4. 26 CFR 1.6072-3 - Income tax due dates postponed in case of China Trade Act corporations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 13 2012-04-01 2012-04-01 false Income tax due dates postponed in case of China... and Other Documents § 1.6072-3 Income tax due dates postponed in case of China Trade Act corporations..., 1956, the income tax return of any corporation organized under the China Trade Act of 1922 (15 U.S.C...

  5. 26 CFR 1.6072-3 - Income tax due dates postponed in case of China Trade Act corporations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 13 2014-04-01 2014-04-01 false Income tax due dates postponed in case of China... and Other Documents § 1.6072-3 Income tax due dates postponed in case of China Trade Act corporations..., 1956, the income tax return of any corporation organized under the China Trade Act of 1922 (15 U.S.C...

  6. 26 CFR 1.6072-3 - Income tax due dates postponed in case of China Trade Act corporations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 13 2013-04-01 2013-04-01 false Income tax due dates postponed in case of China... and Other Documents § 1.6072-3 Income tax due dates postponed in case of China Trade Act corporations..., 1956, the income tax return of any corporation organized under the China Trade Act of 1922 (15 U.S.C...

  7. 26 CFR 1.6072-3 - Income tax due dates postponed in case of China Trade Act corporations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Income tax due dates postponed in case of China... Documents § 1.6072-3 Income tax due dates postponed in case of China Trade Act corporations. (a) With... tax return of any corporation organized under the China Trade Act of 1922 (15 U.S.C. ch. 4), as...

  8. 26 CFR 1.6072-3 - Income tax due dates postponed in case of China Trade Act corporations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 13 2011-04-01 2011-04-01 false Income tax due dates postponed in case of China... and Other Documents § 1.6072-3 Income tax due dates postponed in case of China Trade Act corporations..., 1956, the income tax return of any corporation organized under the China Trade Act of 1922 (15 U.S.C...

  9. Nickel-hydrogen CPV battery update

    NASA Technical Reports Server (NTRS)

    Jones, Kenneth R.; Zagrodnik, Jeffrey P.

    1993-01-01

    The multicell common pressure vessel (CPV) nickel hydrogen battery manufactured by Johnson Controls Battery Group, Inc. has completed full flight qualification, including random vibration at 19.5 g for two minutes in each axis, electrical characterization in a thermal vacuum chamber, and mass-spectroscopy vessel leak detection. A first launch is scheduled for late in 1992 or early 1993 by the Naval Research Laboratory (NRL). Specifics of the launch date are not available at this time due to the classified nature of the program. Release of orbital data for the battery is anticipated following the launch.

  10. Estimation of past intermittent methane seep activity using radiocarbon dating of Calyptogena shells in the eastern Nankai subduction zone

    NASA Astrophysics Data System (ADS)

    Yagasaki, K.; Ashi, J.; Yokoyama, Y.; Miyairi, Y.; Kuramoto, S.

    2013-12-01

    Radioisotope carbon dating samples from the deep ocean has always been a difficult phenomenon due to the carbon offset present. This research presents a way of utilizing such method to date shell samples in order to study past fault activities. The research presented will be based on the preliminary data collected thus far. The Nankai and the Tokai regions are common areas for cold seeps, where seepage of hydrogen sulfide and methane rich fluid occurs. These various substances encourage the growth of Calyptogena colonies to flourish at these sites. Cold seeps generally occur at tectonically active continental margins and are mostly ephemeral. This suggests that the cold seep events are possibly influenced by the tectonic activity during the plate divergence. In 1997, a submersible dive by Shinkai 2000 discovered an unusually large Calyptogena colony ranging over 200 m2 off Daini Tenryu Knoll. Majority of the shells were fossilized with few live shells remaining. It is assumed that past tectonic events in the region may have caused a high flux of methane fluid or gas to be released, making it possible to support such a vast scale colony to survive until their eventual death. Previous attempt to reconstruct the cold seep activity history through amino acid racemisation dating revealed two different age grouped shells. Further data using a different method is required to prove its reliability, as acid racemization dating technique can easily be affected by seawater temperature changes and microbial activity. This consequently alters the protein structure of the sample and its overall age. As 14C radioisotope dating is not affected by temperature change, it will provide additional information to the accuracy of the acid racemisation dating of the shell. However, the possibility of contamination is likely due to the shells incorporating older carbon from the sediments during their early stages of growth. The old carbon value can be calculated by subtracting the formerly alive shell age away from the fossilsed shell age. Preliminary results of radiocarbon dating indicate a distinct age gap of several hundred years between the formerly alive shells (~ 1126calAD -1276calAD) and the fossil shells (~ 671calAD - 797calAD).

  11. Polyphenol-Rich Dry Common Beans (Phaseolus vulgaris L.) and Their Health Benefits

    PubMed Central

    Ganesan, Kumar

    2017-01-01

    Polyphenols are plant metabolites with potent anti-oxidant properties, which help to reduce the effects of oxidative stress-induced dreaded diseases. The evidence demonstrated that dietary polyphenols are of emerging increasing scientific interest due to their role in the prevention of degenerative diseases in humans. Possible health beneficial effects of polyphenols are based on the human consumption and their bioavailability. Common beans (Phaseolus vulgaris L.) are a greater source of polyphenolic compounds with numerous health promoting properties. Polyphenol-rich dry common beans have potential effects on human health, and possess anti-oxidant, anti-diabetic, anti-obesity, anti-inflammatory and anti-mutagenic and anti-carcinogenic properties. Based on the studies, the current comprehensive review aims to provide up-to-date information on the nutritional compositions and health-promoting effect of polyphenol-rich common beans, which help to explore their therapeutic values for future clinical studies. Investigation of common beans and their impacts on human health were obtained from various library databases and electronic searches (Science Direct PubMed, and Google Scholar). PMID:29113066

  12. Abrupt climate changes during Termination III in Southern Europe

    PubMed Central

    Pérez-Mejías, Carlos; Moreno, Ana; Sancho, Carlos; Bartolomé, Miguel; Stoll, Heather; Cacho, Isabel; Cheng, Hai; Edwards, R. Lawrence

    2017-01-01

    The Late Quaternary glacial–interglacial transitions represent the highest amplitude climate changes over the last million years. Unraveling the sequence of events and feedbacks at Termination III (T-III), including potential abrupt climate reversals similar to those of the last Termination, has been particularly challenging due to the scarcity of well-dated records worldwide. Here, we present speleothem data from southern Europe covering the interval from 262.7 to 217.9 kyBP, including the transition from marine isotope stage (MIS) 8 to MIS 7e. High-resolution δ13C, δ18O, and Mg/Ca profiles reveal major millennial-scale changes in aridity manifested in changing water availability and vegetation productivity. uranium–thorium dates provide a solid chronology for two millennial-scale events (S8.1 and S8.2) which, compared with the last two terminations, has some common features with Heinrich 1 and Heinrich 2 in Termination I (T-I). PMID:28874530

  13. Abrupt climate changes during Termination III in Southern Europe.

    PubMed

    Pérez-Mejías, Carlos; Moreno, Ana; Sancho, Carlos; Bartolomé, Miguel; Stoll, Heather; Cacho, Isabel; Cheng, Hai; Edwards, R Lawrence

    2017-09-19

    The Late Quaternary glacial-interglacial transitions represent the highest amplitude climate changes over the last million years. Unraveling the sequence of events and feedbacks at Termination III (T-III), including potential abrupt climate reversals similar to those of the last Termination, has been particularly challenging due to the scarcity of well-dated records worldwide. Here, we present speleothem data from southern Europe covering the interval from 262.7 to 217.9 kyBP, including the transition from marine isotope stage (MIS) 8 to MIS 7e. High-resolution δ 13 C, δ 18 O, and Mg/Ca profiles reveal major millennial-scale changes in aridity manifested in changing water availability and vegetation productivity. uranium-thorium dates provide a solid chronology for two millennial-scale events (S8.1 and S8.2) which, compared with the last two terminations, has some common features with Heinrich 1 and Heinrich 2 in Termination I (T-I).

  14. Abrupt climate changes during Termination III in Southern Europe

    NASA Astrophysics Data System (ADS)

    Pérez-Mejías, Carlos; Moreno, Ana; Sancho, Carlos; Bartolomé, Miguel; Stoll, Heather; Cacho, Isabel; Cheng, Hai; Edwards, R. Lawrence

    2017-09-01

    The Late Quaternary glacial-interglacial transitions represent the highest amplitude climate changes over the last million years. Unraveling the sequence of events and feedbacks at Termination III (T-III), including potential abrupt climate reversals similar to those of the last Termination, has been particularly challenging due to the scarcity of well-dated records worldwide. Here, we present speleothem data from southern Europe covering the interval from 262.7 to 217.9 kyBP, including the transition from marine isotope stage (MIS) 8 to MIS 7e. High-resolution δ13C, δ18O, and Mg/Ca profiles reveal major millennial-scale changes in aridity manifested in changing water availability and vegetation productivity. uranium-thorium dates provide a solid chronology for two millennial-scale events (S8.1 and S8.2) which, compared with the last two terminations, has some common features with Heinrich 1 and Heinrich 2 in Termination I (T-I).

  15. Romantic relationship stages and social networking sites: uncertainty reduction strategies and perceived relational norms on facebook.

    PubMed

    Fox, Jesse; Anderegg, Courtney

    2014-11-01

    Due to their pervasiveness and unique affordances, social media play a distinct role in the development of modern romantic relationships. This study examines how a social networking site is used for information seeking about a potential or current romantic partner. In a survey, Facebook users (N=517) were presented with Facebook behaviors categorized as passive (e.g., reading a partner's profile), active (e.g., "friending" a common third party), or interactive (e.g., commenting on the partner's wall) uncertainty reduction strategies. Participants reported how normative they perceived these behaviors to be during four possible stages of relationship development (before meeting face-to-face, after meeting face-to-face, casual dating, and exclusive dating). Results indicated that as relationships progress, perceived norms for these behaviors change. Sex differences were also observed, as women perceived passive and interactive strategies as more normative than men during certain relationship stages.

  16. Optimization of Sugar Replacement with Date Syrup in Prebiotic Chocolate Milk Using Response Surface Methodology.

    PubMed

    Kazemalilou, Sahar; Alizadeh, Ainaz

    2017-01-01

    Chocolate milk is one of the most commonly used non-fermentative dairy products, which, due to high level of sucrose, could lead to diabetes and tooth decay among children. Therefore, it is important to replace sucrose with other types of sweeteners, especially, natural ones. In this research, response surface methodology (RSM) was used to optimize the ingredients formulation of prebiotic chocolate milk, date syrup as sweetener (4-10%w/w), inulin as prebiotic texturizer (0-0.5%w/w) and carrageenan as thickening agent (0-0.04%w/w) in the formulation of chocolate milk. The fitted models to predict the variables of selected responses such as pH, viscosity, total solid, sedimentation and overall acceptability of chocolate milk showed a high coefficient of determination. The independent effect of carrageenan was the most effective parameter which led to pH and sedimentation decrease but increased viscosity. Moreover, in most treatments, date syrup and inulin variables had significant effects which had a mutual impact. Optimization of the variables, based on the responses surface 3D plots showed that the sample containing 0.48% (w/w) of inulin, 0.04% (w/w) of carrageenan, and 10% of date syrup was selected as the optimum condition.

  17. Dating Middle Pleistocene loess using IRSL luminescence

    NASA Astrophysics Data System (ADS)

    Michel, L.

    2008-12-01

    Loess is a unique palaeoclimate proxy that has a relatively global distribution. A major issue in loess studies is their age, as most terrestrial sediments are outside the realm of isotopic dating methods. Luminescence dating of loess has been attempted with limited success as Optically Stimulated Luminescence (OSL) from the two common dosimeters used in luminescence, quartz and feldspar minerals, both yielded age underestimates. Quartz is limited by dose saturation and feldspar suffers from anomalous fading. Over the last decade, we have developed methods to deal with anomalous fading and hence correct Infrared Stimulated Luminescence (IRSL) ages from feldspar dominated samples. A method known as Dose Rate Correction (DRC) has been successfully applied to loess from the Western European Belt, for ages as old as the Middle Pleistocene. Ages using the same method have been obtained for loess in Alaska and the technique is now being extended to loess from Illinois and China. IRSL can also be used as a reliable telecorrelation tool as luminescence properties of loess are broadly similar, whatever the geological provenance. DRC corrected IRSL extends the applicability of luminescence to dating loess up to at least 500 ka. The limiting factor in the specific case of loess is dose saturation due to relatively high dose rate compared to the average terrestrial sediment radioactivity.

  18. 77 FR 47144 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-07

    ... Due to Extraordinary Market Volatility, To Extend the Effective Date of the Pilot Until February 4... extraordinary market volatility, to extend the effective date of the pilot by which such rule operates from the... individual securities due to extraordinary market volatility, to extend the effective date of the pilot by...

  19. 75 FR 22159 - Major Portion Prices and Due Date for Additional Royalty Payments on Indian Gas Production in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ... of major portion prices for calendar year 2008. SUMMARY: Final regulations for valuing gas produced from Indian leases, published August 10, 1999, require MMS to determine major portion prices and notify... provides major portion prices for the 12 months of calendar year 2008. DATES: The due date to pay...

  20. 76 FR 13431 - Major Portion Prices and Due Date for Additional Royalty Payments on Indian Gas Production in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-11

    ...: Notice of major portion prices for calendar year 2009. SUMMARY: Final regulations for valuing gas produced from Indian leases, published August 10, 1999, require the Office of Natural Resources Revenue... calendar year 2009. DATES: The due date to pay additional royalties based on the major portion prices is...

  1. 75 FR 59057 - Common Crop Insurance Regulations, Cotton Crop Insurance Provisions and Macadamia Nut Crop...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ... Crop Insurance Regulations, Cotton Crop Insurance Provisions and Macadamia Nut Crop Insurance... cotton and macadamia nuts that published March 30, 2010. DATES: Effective Date: September 27, 2010. FOR... Common Crop Insurance Regulations, Basic Provisions and applicable Crop Provisions, including the Cotton...

  2. The Role of Perceptions in Dating Violence among Young Adolescents

    ERIC Educational Resources Information Center

    Prospero, Moises

    2006-01-01

    The high prevalence of dating violence and the severity of its aftermath warrant the collaboration between research and practice for the development of prevention and intervention programs. This study investigates young adolescents' perceptions of dating partner's behaviors in common dating situations and their behavioral reaction to these dating…

  3. 12 CFR 717.28 - Effective date, compliance date, and prospective application.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Effective date, compliance date, and prospective application. 717.28 Section 717.28 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION... eligibility information when such information is placed into a common database and is accessible by you. ...

  4. 12 CFR 717.28 - Effective date, compliance date, and prospective application.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Effective date, compliance date, and prospective application. 717.28 Section 717.28 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION... eligibility information when such information is placed into a common database and is accessible by you. ...

  5. 12 CFR 717.28 - Effective date, compliance date, and prospective application.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Effective date, compliance date, and prospective application. 717.28 Section 717.28 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION... eligibility information when such information is placed into a common database and is accessible by you. ...

  6. 12 CFR 717.28 - Effective date, compliance date, and prospective application.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Effective date, compliance date, and prospective application. 717.28 Section 717.28 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION... eligibility information when such information is placed into a common database and is accessible by you. ...

  7. 12 CFR 717.28 - Effective date, compliance date, and prospective application.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Effective date, compliance date, and prospective application. 717.28 Section 717.28 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION... eligibility information when such information is placed into a common database and is accessible by you. ...

  8. Plutonium age dating reloaded

    NASA Astrophysics Data System (ADS)

    Sturm, Monika; Richter, Stephan; Aregbe, Yetunde; Wellum, Roger; Mayer, Klaus; Prohaska, Thomas

    2014-05-01

    Although the age determination of plutonium is and has been a pillar of nuclear forensic investigations for many years, additional research in the field of plutonium age dating is still needed and leads to new insights as the present work shows: Plutonium is commonly dated with the help of the 241Pu/241Am chronometer using gamma spectrometry; in fewer cases the 240Pu/236U chronometer has been used. The age dating results of the 239Pu/235U chronometer and the 238Pu/234U chronometer are scarcely applied in addition to the 240Pu/236U chronometer, although their results can be obtained simultaneously from the same mass spectrometric experiments as the age dating result of latter. The reliability of the result can be tested when the results of different chronometers are compared. The 242Pu/238U chronometer is normally not evaluated at all due to its sensitivity to contamination with natural uranium. This apparent 'weakness' that renders the age dating results of the 242Pu/238U chronometer almost useless for nuclear forensic investigations, however turns out to be an advantage looked at from another perspective: the 242Pu/238U chronometer can be utilized as an indicator for uranium contamination of plutonium samples and even help to identify the nature of this contamination. To illustrate this the age dating results of all four Pu/U clocks mentioned above are discussed for one plutonium sample (NBS 946) that shows no signs of uranium contamination and for three additional plutonium samples. In case the 242Pu/238U chronometer results in an older 'age' than the other Pu/U chronometers, contamination with either a small amount of enriched or with natural or depleted uranium is for example possible. If the age dating result of the 239Pu/235U chronometer is also influenced the nature of the contamination can be identified; enriched uranium is in this latter case a likely cause for the missmatch of the age dating results of the Pu/U chronometers.

  9. Estimating Divergence Dates and Substitution Rates in the Drosophila Phylogeny

    PubMed Central

    Obbard, Darren J.; Maclennan, John; Kim, Kang-Wook; Rambaut, Andrew; O’Grady, Patrick M.; Jiggins, Francis M.

    2012-01-01

    An absolute timescale for evolution is essential if we are to associate evolutionary phenomena, such as adaptation or speciation, with potential causes, such as geological activity or climatic change. Timescales in most phylogenetic studies use geologically dated fossils or phylogeographic events as calibration points, but more recently, it has also become possible to use experimentally derived estimates of the mutation rate as a proxy for substitution rates. The large radiation of drosophilid taxa endemic to the Hawaiian islands has provided multiple calibration points for the Drosophila phylogeny, thanks to the "conveyor belt" process by which this archipelago forms and is colonized by species. However, published date estimates for key nodes in the Drosophila phylogeny vary widely, and many are based on simplistic models of colonization and coalescence or on estimates of island age that are not current. In this study, we use new sequence data from seven species of Hawaiian Drosophila to examine a range of explicit coalescent models and estimate substitution rates. We use these rates, along with a published experimentally determined mutation rate, to date key events in drosophilid evolution. Surprisingly, our estimate for the date for the most recent common ancestor of the genus Drosophila based on mutation rate (25–40 Ma) is closer to being compatible with independent fossil-derived dates (20–50 Ma) than are most of the Hawaiian-calibration models and also has smaller uncertainty. We find that Hawaiian-calibrated dates are extremely sensitive to model choice and give rise to point estimates that range between 26 and 192 Ma, depending on the details of the model. Potential problems with the Hawaiian calibration may arise from systematic variation in the molecular clock due to the long generation time of Hawaiian Drosophila compared with other Drosophila and/or uncertainty in linking island formation dates with colonization dates. As either source of error will bias estimates of divergence time, we suggest mutation rate estimates be used until better models are available. PMID:22683811

  10. Leaflet embolisation from Duromedics valves: a report of two cases.

    PubMed

    Kumar, N; Balasundaram, S; Rickard, M; al Halees, Z; Duran, C M

    1991-12-01

    Embolization of parts of mechanical valves has been reported since the inception of prosthetic valve implantation. We report here two cases of embolization of one hemileaflet of a Duromedic bileaflet prosthesis in the mitral position due to a pivot fracture. Both presented with moderately severe mitral regurgitation and pulmonary edema and were successfully managed by replacement of the malfunctioning prostheses. The embolised disc was located in the left common iliac artery by abdominal ultrasound and removed by an inguinal, retroperitoneal approach with low morbidity. Both patients left hospital and are doing well to-date.

  11. Hyper-temporal remote sensing for digital soil mapping: Characterizing soil-vegetation response to climatic variability

    USDA-ARS?s Scientific Manuscript database

    Indices derived from remotely-sensed imagery are commonly used to predict soil properties with digital soil mapping (DSM) techniques. The use of images from single dates or a small number of dates is most common for DSM; however, selection of the appropriate images is complicated by temporal variabi...

  12. High-Precision U-Pb Geochronology of Ice River Perovskite: A Possible Interlaboratory and Intertechnique EARTHTIME Standard

    NASA Astrophysics Data System (ADS)

    Burgess, S. D.; Bowring, S. A.; Heaman, L. M.

    2012-12-01

    Accurate and precise U-Pb geochronology of accessory phases other than zircon are required for dating some LIP basalts or determining the temporal patterns of kimberlite pipes, for example. Advances in precision and accuracy lead directly to an increase in the complexity of questions that can be posed. U-Pb geochronology of perovskite (CaTiO3) has been applied to silica-undersaturated basalts, carbonatites, alkaline igneous rocks, and kimberlites. Most published IDTIMS perovskite dates have 2-sigma precisions at the ~0.2% level for weighted mean 206Pb/238U dates, much less than possible with IDTIMS analyses of zircons, which limits the applicability of perovskite in high-precision applications. Precision on perovskite dates is lower than zircon because of common Pb, which in some cases can be up to 50% of the total Pb and must be corrected for and accurately partitioned between blank and initial. Relatively small changes in the composition of common Pb can result in inaccurate but precise dates. In many cases minerals with significant common Pb are corrected using Stacey and Kramers (1975) two stage Pb evolution model. This can be done without serious consequence to the final date for minerals with high U/Pb ratios. In the more common case where U/Pb ratios are relatively low and the proportion of common Pb is large, applying a model-derived Pb isotopic composition rather than measuring it directly can introduce percent-level inaccuracy to dates calculated with precisely known U/Pb ratios. Direct measurement of the common Pb composition can be done on a U-poor mineral that co-crystallized with perovskite; feldspar and clinopyroxene are commonly used. Clinopyroxene can contain significant in-grown radiogenic Pb and our experiments indicate that it is not eliminated by aggressive step-wise leaching. The U/Pb ratio in clinopyroxene is generally low (20 < mu < 50) but significant. Other workers (e.g. Kamo et al., 2003; Corfu and Dahlgren, 2008), have used two methods to determine the amount of ingrown Pb. First, by measuring the U/Pb ratio in clinopyroxene and assuming a crystallization age the amount of ingrown Pb can be calculated. Second, by assuming that perovskite and clinopyroxene (± other phases) are isochronous, the initial Pb isotopic composition can be calculated using the y-intercept on 206Pb/238U, 207Pb/235U, and 3-D isochron diagrams. To further develop a perovskite mineral standard for use in high-precision dating applications, we have focused on single grains/fragments of perovskite and multi-grain clinopyroxene fractions from a melteigite sample (IR90.3) within the Ice River complex, a zoned alkaline-ultramafic intrusion in southeastern British Columbia. Perovskite from this sample has variable measured 206Pb/204Pb (22-263), making this an ideal sample on which to test the sensitivity of the date on grains with variable amounts of radiogenic Pb to changes in common Pb composition. Using co-existing clinopyroxene for the initial common Pb composition by both direct measurement and by the isochron method allows us to calculate an accurate weighted-mean 206Pb/238U date on perovskite at the < 0.1% level, which overlaps within uncertainty for the two different methods. We recommend the Ice River 90.3 perovskite as a suitable EARTHTIME standard for interlaboratory and intertechnique comparison.

  13. Single Machine Scheduling and Due Date Assignment with Past-Sequence-Dependent Setup Time and Position-Dependent Processing Time

    PubMed Central

    Zhao, Chuan-Li; Hsu, Hua-Feng

    2014-01-01

    This paper considers single machine scheduling and due date assignment with setup time. The setup time is proportional to the length of the already processed jobs; that is, the setup time is past-sequence-dependent (p-s-d). It is assumed that a job's processing time depends on its position in a sequence. The objective functions include total earliness, the weighted number of tardy jobs, and the cost of due date assignment. We analyze these problems with two different due date assignment methods. We first consider the model with job-dependent position effects. For each case, by converting the problem to a series of assignment problems, we proved that the problems can be solved in O(n 4) time. For the model with job-independent position effects, we proved that the problems can be solved in O(n 3) time by providing a dynamic programming algorithm. PMID:25258727

  14. Single machine scheduling and due date assignment with past-sequence-dependent setup time and position-dependent processing time.

    PubMed

    Zhao, Chuan-Li; Hsu, Chou-Jung; Hsu, Hua-Feng

    2014-01-01

    This paper considers single machine scheduling and due date assignment with setup time. The setup time is proportional to the length of the already processed jobs; that is, the setup time is past-sequence-dependent (p-s-d). It is assumed that a job's processing time depends on its position in a sequence. The objective functions include total earliness, the weighted number of tardy jobs, and the cost of due date assignment. We analyze these problems with two different due date assignment methods. We first consider the model with job-dependent position effects. For each case, by converting the problem to a series of assignment problems, we proved that the problems can be solved in O(n(4)) time. For the model with job-independent position effects, we proved that the problems can be solved in O(n(3)) time by providing a dynamic programming algorithm.

  15. The distribution and most recent common ancestor of the 17q21 inversion in humans.

    PubMed

    Donnelly, Michael P; Paschou, Peristera; Grigorenko, Elena; Gurwitz, David; Mehdi, Syed Qasim; Kajuna, Sylvester L B; Barta, Csaba; Kungulilo, Selemani; Karoma, N J; Lu, Ru-Band; Zhukova, Olga V; Kim, Jong-Jin; Comas, David; Siniscalco, Marcello; New, Maria; Li, Peining; Li, Hui; Manolopoulos, Vangelis G; Speed, William C; Rajeevan, Haseena; Pakstis, Andrew J; Kidd, Judith R; Kidd, Kenneth K

    2010-02-12

    The polymorphic inversion on 17q21, sometimes called the microtubular associated protein tau (MAPT) inversion, is an approximately 900 kb inversion found primarily in Europeans and Southwest Asians. We have identified 21 SNPs that act as markers of the inverted, i.e., H2, haplotype. The inversion is found at the highest frequencies in Southwest Asia and Southern Europe (frequencies of approximately 30%); elsewhere in Europe, frequencies vary from < 5%, in Finns, to 28%, in Orcadians. The H2 inversion haplotype also occurs at low frequencies in Africa, Central Asia, East Asia, and the Americas, though the East Asian and Amerindian alleles may be due to recent gene flow from Europe. Molecular evolution analyses indicate that the H2 haplotype originally arose in Africa or Southwest Asia. Though the H2 inversion has many fixed differences across the approximately 900 kb, short tandem repeat polymorphism data indicate a very recent date for the most recent common ancestor, with dates ranging from 13,600 to 108,400 years, depending on assumptions and estimation methods. This estimate range is much more recent than the 3 million year age estimated by Stefansson et al. in 2005. Copyright (c) 2010 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

  16. A Phenomenological Investigation of Adolescent Dating Relationships and Dating Violence Counseling Interventions

    ERIC Educational Resources Information Center

    Hays, Danica G.; Michel, Rebecca E.; Cole, Rebekah F.; Emelianchik, Kelly; Forman, Julia; Lorelle, Sonya; McBride, Rebecca; Sikes, April

    2011-01-01

    Despite the prevalence of dating violence, incidences often go unreported due to a lack of awareness among students as to appropriate dating behaviors. This phenomenology investigated how adolescents conceptualize and experience dating relationships. We explored adolescent females' definitions of healthy and abusive relationships, experiences with…

  17. 77 FR 12825 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    .... Accession Number: 20120223-5087. Comments Due: 5 p.m. ET 3/6/12. Docket Numbers: RP12-397-000. Applicants.../2012. Filed Date: 2/24/12. Accession Number: 20120224-5000. Comments Due: 5 p.m. ET 3/7/12. Docket.... Filed Date: 2/23/12. Accession Number: 20120223-5115. Comments Due: 5 p.m. ET 3/1/12. Any person...

  18. 76 FR 19683 - Conservation Program Recipient Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-08

    ... regulation that has application or plan due dates after October 1, 2010. The Watershed Operations and Flood Prevention Program, Emergency Watersheds Protection Program, Healthy Forests Reserve Program, Agricultural Management Assistance Program, and the Conservation Stewardship Program have application or plan due dates...

  19. Genetic programming for evolving due-date assignment models in job shop environments.

    PubMed

    Nguyen, Su; Zhang, Mengjie; Johnston, Mark; Tan, Kay Chen

    2014-01-01

    Due-date assignment plays an important role in scheduling systems and strongly influences the delivery performance of job shops. Because of the stochastic and dynamic nature of job shops, the development of general due-date assignment models (DDAMs) is complicated. In this study, two genetic programming (GP) methods are proposed to evolve DDAMs for job shop environments. The experimental results show that the evolved DDAMs can make more accurate estimates than other existing dynamic DDAMs with promising reusability. In addition, the evolved operation-based DDAMs show better performance than the evolved DDAMs employing aggregate information of jobs and machines.

  20. Local temperatures predict breeding phenology but do not result in breeding synchrony among a community of resident cavity-nesting birds.

    PubMed

    Drake, Anna; Martin, Kathy

    2018-02-09

    Weather and ecological factors are known to influence breeding phenology and thus individual fitness. We predicted concordance between weather conditions and annual variation in phenology within a community of eight resident, cavity-nesting bird species over a 17-year period. We show that, although clutch initiation dates for six of our eight species are correlated with local daily maximum temperatures, this common driver does not produce a high degree of breeding synchrony due to species-specific responses to conditions during different periods of the preceding winter or spring. These "critical temperature periods" were positively associated with average lay date for each species, although the interval between critical periods and clutch initiation varied from 4-78 days. The ecological factors we examined (cavity availability and a food pulse) had an additional influence on timing in only one of our eight focal species. Our results have strong implications for understanding heterogeneous wildlife responses to climate change: divergent responses would be expected within communities where species respond to local conditions within different temporal windows, due to differing warming trends between winter and spring. Our system therefore indicates that climate change could alter relative breeding phenology among sympatric species in temperate ecosystems.

  1. 78 FR 45519 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-29

    ... Carthage Energy, LLC, et al. Filed Date: 7/22/13. Accession Number: 20130722-5091. Comments Due: 5 p.m. ET... Number: 20130719-5162. Comments Due: 5 p.m. ET 8/9/13. Docket Numbers: EG13-48-000. Applicants: Desert... Sunlight 300, LLC. Filed Date: 7/19/13. Accession Number: 20130719-5167. Comments Due: 5 p.m. ET 8/9/13...

  2. 78 FR 49741 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-15

    ...-5158. Comments Due: 5 p.m. ET 8/16/13. Docket Numbers: ER13-1865-001. Applicants: Tesoro Refining.../2013. Filed Date: 8/7/13. Accession Number: 20130807-5079. Comments Due: 5 p.m. ET 8/28/13. Docket... effective 7/30/2013. Filed Date: 8/6/13. Accession Number: 20130806-5195. Comments Due: 5 p.m. ET 8/27/13...

  3. 78 FR 30298 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... Number: 20130514-5082. Comments Due: 5 p.m. ET 6/4/13. Docket Numbers: ER13-1484-000. [[Page 30299.... 3555 to be effective 4/11/2013. Filed Date: 5/13/13. Accession Number: 20130513-5203. Comments Due: 5 p... be effective 4/10/2013. Filed Date: 5/14/13. Accession Number: 20130514-5016. Comments Due: 5 p.m. ET...

  4. A common and optimized age scale for Antarctic ice cores

    NASA Astrophysics Data System (ADS)

    Parrenin, F.; Veres, D.; Landais, A.; Bazin, L.; Lemieux-Dudon, B.; Toye Mahamadou Kele, H.; Wolff, E.; Martinerie, P.

    2012-04-01

    Dating ice cores is a complex problem because 1) there is a age shift between the gas bubbles and the surrounding ice 2) there are many different ice cores which can be synchronized with various proxies and 3) there are many methods to date the ice and the gas bubbles, each with advantages and drawbacks. These methods fall into the following categories: 1) Ice flow (for the ice) and firn densification modelling (for the gas bubbles); 2) Comparison of ice core proxies with insolation variations (so-called orbital tuning methods); 3) Comparison of ice core proxies with other well dated archives; 4) Identification of well-dated horizons, such as tephra layers or geomagnetic anomalies. Recently, an new dating tool has been developped (DATICE, Lemieux-Dudon et al., 2010), to take into account all the different dating information into account and produce a common and optimal chronology for ice cores with estimated confidence intervals. In this talk we will review the different dating information for Antarctic ice cores and show how the DATICE tool can be applied.

  5. Dating Relationships in Older Adulthood: A National Portrait

    PubMed Central

    Brown, Susan L.; Shinohara, Sayaka K.

    2013-01-01

    Dating in later life is likely common, especially as the proportion of older adults who are single continues to rise. Yet there are no recent national estimates of either the prevalence or factors associated with dating during older adulthood. Using data from the 2005-2006 National Social Life, Health, and Aging Project, a nationally representative sample of 3,005 individuals ages 57-85, the authors constructed a national portrait of older adult daters. Roughly 14% of singles were in a dating relationship. Dating was more common among men than women and declined with age. Compared to non-daters, daters were more socially advantaged. Daters were more likely to be college educated and had more assets, were in better health, and reported more social connectedness. This study underscores the importance of new research on partnering in later life, particularly with the aging of the U.S. population and the swelling ranks of older singles. PMID:24319296

  6. Facts about the Common Cold

    MedlinePlus

    ... each(function(i){ var city = $(this).find('city').text(); var state = $(this).find('state').text(); var date = $(this).find('date').text(); if ((city != "") && (state != "")){ var citystate = ' | ' + city + ', ' + state; } else ...

  7. Fluoroscopic studies of the upper gastrointestinal tract: techniques and indications.

    PubMed

    Sánchez-Carpintero de la Vega, M; García Villar, C

    Fluoroscopic studies of the gastrointestinal tract are becoming increasing less common due to the introduction of other imaging techniques such as computed tomography and magnetic resonance imaging and to the increased availability of endoscopy. Nevertheless, fluoroscopic studies of the gastrointestinal tract continue to appear in clinical guidelines and some of their indications are still valid. These studies are dynamic, operator-dependent examinations that require training to obtain the maximum diagnostic performance. This review aims to describe the technique and bring the indications for this imaging modality up to date. Copyright © 2016 SERAM. Publicado por Elsevier España, S.L.U. All rights reserved.

  8. Enterobius vermicularis infestation leading to Meckel's diverticulitis in an adolescent boy: An extremely rare presentation.

    PubMed

    Sharma, Manupriya; Kaul, Rashmi; Chander, Bal

    2018-01-01

    Enterobius vermicularis is an intestinal nematode commonly affecting children worldwide. Its transmission is by feco-oral route. Meckel's diverticulitis due to E. vermicularis infestation is an extremely rare presentation. An 11-year-old boy presented with acute abdomen. During surgery inflamed Meckel's diverticulum (M.D) was seen. Histopathology examination of specimen revealed E. vermicularis . Till date, only one case of E. vermicularis infestation of M.D is reported around five decades ago. This histopathological confirmation is extremely important as the required treatment (Mebendazole) of the infected case along with household contacts can prevent the spread of infection and may avoid surgery in known contacts.

  9. Mechanism of immune evasion in breast cancer

    PubMed Central

    Wang, Mozhi; Zhang, Changwang; Song, Yongxi; Wang, Zhenning; Wang, Yaojia; Luo, Fang; Xu, Yujie; Zhao, Yi; Wu, Zhonghua; Xu, Yingying

    2017-01-01

    Breast cancer (BC) is the most common malignant tumor among women, with high morbidity and mortality. Its onset, development, metastasis, and prognosis vary among individuals due to the interactions between tumors and host immunity. Many diverse mechanisms have been associated with BC, with immune evasion being the most widely studied to date. Tumor cells can escape from the body’s immune response, which targets abnormal components and foreign bodies, using different approaches including modification of surface antigens and modulation of the surrounding environment. In this review, we summarize the mechanisms and factors that impact the immunoediting process and analyze their functions in detail. PMID:28352189

  10. [Premature orgasm in the male].

    PubMed

    Köhn, F M

    2003-11-13

    To date, we have no uniform definition of ejaculatio praecox. In a qualitative approach, premature ejaculation is ascribed to a failure to control excitement. As causes, organic disorders and erectile dysfunction must be excluded. The majority of cases, however, are due to psychological or partnership problems. The history-taking should aim, in particular, to uncover possible anxiety in conjunction with premature orgasm, and also to establish the reactions of the partner. As therapy, medication (local anesthetics, antidepressive agents, PDE-5 inhibitors) and sexual-therapeutic measures are available. Since few sufferers take the initiative in seeking treatment, particular importance attaches to providing the public with information about the therapeutic options for treating this common disorder.

  11. 78 FR 25070 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-29

    ... Number: 20130419-5083 Comments Due: 5 p.m. ET 4/29/13 Docket Numbers: EC13-95-000 Applicants: AP Holdings... Status of CCI Roseton LLC. Filed Date: 4/18/13 Accession Number: 20130418-5223 Comments Due: 5 p.m. ET 5.... Filed Date: 4/18/13 Accession Number: 20130418-5186 Comments Due: 5 p.m. ET 5/9/13 Docket Numbers: ER13...

  12. Developing Q-methodology to explore staff views toward the use of technology in nurse education.

    PubMed

    Petit dit Dariel, Odessa; Wharrad, Heather; Windle, Richard

    2010-01-01

    Technology in education is moving quickly in terms of the hardware and software applications available, but also due to the expectations of an increasingly digitally competent student population. Academics have to rethink their pedagogy in relation to these changes. Nurse educators, in particular, must face the challenge of effectively integrating technology into what is essentially a hands-on, people-centred profession. To date, the factors most commonly cited as barriers to the adoption of e-learning by academics have focused on explicit and tangible ('hard') issues. Less frequently mentioned are the implicit and tacit ('soft') factors which are harder to identify. This article describes a pilot study using Q-methodology to explore the limitations of commonly used research methods in identifying how these hard and soft issues are prioritised by individuals, through the voices of nurse educators.

  13. Middle School Students' Aggressive Reactions to Dating Situations

    ERIC Educational Resources Information Center

    Prospero, Moises

    2006-01-01

    The present study investigated age differences in reactions to the perceptions of dating violence using both qualitative and quantitative research methods. Focus groups were conducted to develop age and culturally appropriate questionnaires for each age group (college and middle school). The questionnaires consisted of common dating scenarios that…

  14. 29 CFR 4003.5 - Non-timely request for review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Regulations Relating to Labor (Continued) PENSION BENEFIT GUARANTY CORPORATION GENERAL RULES FOR... for review is filed within 30 days after the date the aggrieved person, exercising due diligence at... reconsideration, or within 45 days after the date the aggrieved person, exercising due diligence at all relevant...

  15. Snowpack and variation in reproductive ecology of a montane ground-nesting passerine, Junco hyemalis

    USGS Publications Warehouse

    Smith, Kimberly G.; Andersen, Douglas C.

    1985-01-01

    Effects of snow depth and rate of snowmelt on reproduction of a montane ground-nesting passerine were examined in a 5-year study of Dark-eyed Juncos Junco hyemalis in northern Utah, USA. Distribution of clucth sizes differed significantly among years. Although most clutches contained four eggs, 3-egg clutches, due primarily to second nestings, were more common during a year of early snowmelt and 5-egg clutches were most common during two years of late snowmelt. Average clutch size was lowest in an early snowmelt year and average clutch size and date at which meadows became snow-free were significantly positively correlated. Average hatching date of 4-egg clutches was also significantly positively correlated with date at which meadows became snow-free demonstrating that most birds tracked the pattern of snowmelt. Early snowmelt may allow more pairs to attempt second nesting, but late-lying snow causes breeding to be delayed, allowing time for only one nesting attempt. During this delay, female juncos continue to feed and some may gain enough reserves to produce larger clutches, accounting for the increase in average clutch size in years of late snowmelt. Three female juncos examined in June 1982, a period of late snowmelt, had significantly more lipid reserves than did six males collected at the same time, suggesting that females are not physiologically stressed while awaiting snowmelt. By tracking snowmelt patterns, juncos synchronize production of young with peak summer insect abundance and potentially decrease risk of predation. Snow depth and rate of snowmelt are thus proximate environmental factors that may influence the reproductive ecology of ground-nesting passerines.

  16. X linked mental retardation: a clinical guide.

    PubMed

    Raymond, F L

    2006-03-01

    Mental retardation is more common in males than females in the population, assumed to be due to mutations on the X chromosome. The prevalence of the 24 genes identified to date is low and less common than expansions in FMR1, which cause Fragile X syndrome. Systematic screening of all other X linked genes in X linked families with mental retardation is currently not feasible in a clinical setting. The phenotypes of genes causing syndromic and non-syndromic mental retardation (NLGN3, NLGN4, RPS6KA3(RSK2), OPHN1, ATRX, SLC6A8, ARX, SYN1, AGTR2, MECP2, PQBP1, SMCX, and SLC16A2) are first discussed, as these may be the focus of more targeted mutation analysis. Secondly, the relative prevalence of genes causing only non-syndromic mental retardation (IL1RAPL1, TM4SF2, ZNF41, FTSJ1, DLG3, FACL4, PAK3, ARHGEF6, FMR2, and GDI) is summarised. Thirdly, the problem of recurrence risk where a molecular genetics diagnosis has not been made and what proportion of the male excess of mental retardation is due to monogenic disorders of the X chromosome are discussed.

  17. [Mechanisms and prevention of kitesurfing injuries].

    PubMed

    Petersen, W; Hansen, U; Zernial, O; Nickel, C; Prymka, M

    2002-09-01

    Aim of this study was to analyse the mechanisms of kitesurfing injuries. For this purpose we performed a survey among 72 kitesurfers in the north of Germany. 31 accidents have been registrated among all 72 athletes during the 2001 season. 3 additional accidents occurred where a windsurfer got injured. 5 athletes had medium injuries such as fractures, all remaining athletes presented with minor injuries, that did not require medical treatment. The incidence of medium kite injuries was 1/1000 hours; the incidence of minor kite injuries was 5/1000 hours. The most common injury mechanism was a direct trauma against things such as stones and boats lying on the beach. The most common situation in which the injury occurred was the lost of control about the kite on the beach or close to the beach due to technical mistakes of the surfer, oversized kites, or the wind conditions (onshore wind, overpower). Further injuries occurred due to collisions with windsurfers or sailing boats. Kitesurfing is a new rapidly growing sport. To date the risk potential of this new sport is unclear. The analysis of the injury mechanisms allows conclusion regarding the prevention of kitesurfing injuries.

  18. Multiple Contact Dates and SARS Incubation Periods

    PubMed Central

    2004-01-01

    Many severe acute respiratory syndrome (SARS) patients have multiple possible incubation periods due to multiple contact dates. Multiple contact dates cannot be used in standard statistical analytic techniques, however. I present a simple spreadsheet-based method that uses multiple contact dates to calculate the possible incubation periods of SARS. PMID:15030684

  19. 7 CFR 987.152 - Exemption from regulations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...-pitted dates which meet the grade requirements for DAC dates except for size, or damage due to cutting and pitting. Also, it may permit any handler to sell hand-layered dates in tin, wood, plastic, or...

  20. 7 CFR 987.152 - Exemption from regulations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...-pitted dates which meet the grade requirements for DAC dates except for size, or damage due to cutting and pitting. Also, it may permit any handler to sell hand-layered dates in tin, wood, plastic, or...

  1. 7 CFR 987.152 - Exemption from regulations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...-pitted dates which meet the grade requirements for DAC dates except for size, or damage due to cutting and pitting. Also, it may permit any handler to sell hand-layered dates in tin, wood, plastic, or...

  2. 7 CFR 987.152 - Exemption from regulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...-pitted dates which meet the grade requirements for DAC dates except for size, or damage due to cutting and pitting. Also, it may permit any handler to sell hand-layered dates in tin, wood, plastic, or...

  3. U-Th Burial Dates on Ostrich Eggshell

    NASA Astrophysics Data System (ADS)

    Sharp, W. D.; Fylstra, N. D.; Tryon, C. A.; Faith, J. T.; Peppe, D. J.

    2015-12-01

    Obtaining precise and accurate dates at archaeological sites beyond the range of radiocarbon dating is challenging but essential for understanding human origins. Eggshells of ratites (large flightless birds including ostrich, emu and others) are common in many archaeological sequences in Africa, Australia and elsewhere. Ancient eggshells are geochemically suitable for the U-Th technique (1), which has about ten times the range of radiocarbon dating (>500 rather than 50 ka), making eggshells attractive dating targets. Moreover, C and N isotopic studies of eggshell provide insights into paleovegetation and paleoprecipitation central to assessing past human-environment interactions (2,3). But until now, U-Th dates on ratite eggshell have not accounted for the secondary origin of essentially all of their U. We report a novel approach to U-Th dating of eggshell that explicitly accounts for secondary U uptake that begins with burial. Using ostrich eggshell (OES) from Pleistocene-Holocene east African sites, we have measured U and 232Th concentration profiles across OES by laser ablation ICP-MS. U commonly peaks at 10s to 100s of ppb and varies 10-fold or more across the ~2 mm thickness of OES, with gradients modulated by the layered structure of the eggshell. Common Th is high near the shell surfaces, but low in the middle "pallisade" layer of OES, making it optimal for U-Th dating. We determine U-Th ages along the U concentration gradient by solution ICP-MS analyses of two or more fractions of the pallisade layer. We then estimate OES burial dates using a simple model for diffusive uptake of uranium. Comparing such "U-Th burial dates" with radiocarbon dates for OES calcite from the same shells, we find good agreement in 7 out of 9 cases, consistent with rapid burial and confirming the accuracy of the approach. The remaining 2 eggshells have anomalous patterns of apparent ages that reveal they are unsuitable for U-Th dating, thereby providing reliability criteria innate to the U-Th data. The oldest OES we have analyzed yields a U-Th burial date of ~140 ka, indicating that U-Th burial dating of OES may be applicable throughout the Late Pleistocene. 1. Magee, J.W. et al. (2009) Quatern. Geochron. 4, 84-89. 2. Johnson, B.J. et al. (1998) Geochim. Cosmochim. Acta 62, 2451-2461. 3. Miller, G.H. et al. (2005) Science 309, 287-290.

  4. 24 CFR 206.111 - Due date of MIP.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES HOME EQUITY CONVERSION MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums § 206.111 Due date... of closing and as a condition to the endorsement of the mortgage for insurance. (b) Monthly MIP. Each...

  5. 24 CFR 206.111 - Due date of MIP.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES HOME EQUITY CONVERSION MORTGAGE INSURANCE Contract Rights and Obligations Mortgage Insurance Premiums § 206.111 Due date... of closing and as a condition to the endorsement of the mortgage for insurance. (b) Monthly MIP. Each...

  6. 25 CFR 700.463 - Requirements for applications.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... funding assistance. The preapplication shall be due by the closing date published by the Commission, and... funding cycle. Applications received after the due date will be considered for the next funding cycle, although the Commission, at its discretion, may select such a project for funding under the current cycle...

  7. 20 CFR 606.31 - Due dates for payment of interest. [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Due dates for payment of interest. [Reserved] 606.31 Section 606.31 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR TAX CREDITS UNDER THE FEDERAL UNEMPLOYMENT TAX ACT; ADVANCES UNDER TITLE XII OF THE SOCIAL SECURITY...

  8. Food Product Dating

    MedlinePlus

    ... the product will be of best quality. For example, sausage formulated with certain ingredients used to preserve ... phrases used on labels to describe quality dates. Examples of commonly used phrases: A "Best if Used ...

  9. Ashtabula Breakwater Common Tern (Sterna Hirundo) Nesting

    DTIC Science & Technology

    2016-05-01

    and competition by more aggressive gull species . These impacts have directly contributed to the species being listed as an Ohio endangered species ... species has been successfully accomplished both within the Great Lakes region (Karwowski et al. 1995, Riveredge Associates 2013) and in other regions...control number. 1. REPORT DATE MAY 2016 2. REPORT TYPE 3. DATES COVERED 00-00-2016 to 00-00-2016 4. TITLE AND SUBTITLE Ashtabula Breakwater Common

  10. Common Metrics for Human-Robot Interaction

    DTIC Science & Technology

    2006-03-01

    interaction spectrum. By doing so, we believe that: ( 1 ) our metrics are broadly applicable to a wide range of applications and ( 2 ) we can assess...currently valid OMB control number. 1 . REPORT DATE MAR 2006 2 . REPORT TYPE 3. DATES COVERED 00-00-2006 to 00-00-2006 4. TITLE AND SUBTITLE Common...disambiguate or increase confidence for perceptual inference [ 2 ]). 1 ) Passive Perception: Passive perception involves interpreting sensor data

  11. Glycemic indices, glycemic load and glycemic response for seventeen varieties of dates grown in Saudi Arabia.

    PubMed

    AlGeffari, Metab Ali; Almogbel, Ebtehal Solaiman; Alhomaidan, Homaidan Turki; El-Mergawi, Ragab; Barrimah, Issam Alsaed

    2016-01-01

    Dates are consumed worldwide, and are an important fruit for many individuals in Saudi Arabia. Currently, limited information is available on the glycemic indices of different date varieties. To determine the glycemic index (GI), glycemic load (GL) and glycemic response for 17 common date varieties in Saudi Arabia. Prospective clinical trial on healthy subjects. College of Medicine, Qassim University, Buraydah, Saudi Arabia. The available carbohydrate content of Tamer stage dates was determined using standard laboratory methods. Healthy subjects (ten males and nine females) received 50 g of glucose (on three separate occasions) and 50 g equivalent of available carbohydrates from the seventeen varieties of date (each once). The GI and GL were then calculated. GI, GL, and glycemic response. The mean (SEM) GI of the date samples was 55.2 (7.7) (range, 42.8-74.6). Sellaj and Maktoomi exhibited the highest GI (74.6 [10.1] and 71.0 [11.1]), respectively, whereas Shaqra, Sukkary, and Sag'ai had the lowest GI (42.8 [5.5], 43.4 [4.7] and 44.6 [6]), respectively. The GL of the date samples ranged from 8.5 to 24. Sellaj had a high GL (24), whereas Ajwah and Shaqra had a low GL (8.5 and 9.2). The analyses suggested no significant difference in GI between the date varieties. However, the GL values differed significantly between the 17 date varieties (P < .001). The results provide reliable GI and GL values for 17 common date varieties in Saudi Arabia. The identification of date varieties with lower glycemic responses may help lower the GI of the diet of both healthy and diabetic Saudi individuals. We used dates at the Tamer stage, which may not be translatable to all types of dates.

  12. Titanite chronology, thermometry, and speedometry of ultrahigh-temperature (UHT) calc-silicates from south Madagascar: U-Pb dates, Zr temperatures, and lengthscales of trace-element diffusion

    NASA Astrophysics Data System (ADS)

    Holder, R. M.; Hacker, B. R.

    2017-12-01

    Calc-silicate rocks are often overlooked as sources of pressure-temperature-time data in granulite-UHT metamorphic terranes due to the strong dependence of calc-silicate mineral assemblages on complex fluid compositions and a lack of thermodynamic data on common high-temperature calc-silicate minerals such as scapolite. In the Ediacaran-Cambrian UHT rocks of southern Madagascar, clinopyroxene-scapolite-feldspar-quartz-zircon-titanite calc-silicate rocks are wide-spread. U-Pb dates of 540-520 Ma from unaltered portions of titanite correspond to cooling of the rocks through upper-amphibolite facies and indicate UHT metamorphism occurred before 540 Ma. Zr concentrations in these domains preserve growth temperatures of 900-950 °C, consistent with peak temperatures calculated by pseudosection modeling of nearby osumilite-bearing gneisses. Younger U-Pb dates (510-490 Ma) correspond to fluid-mediated Pb loss from titanite grains, which occurred below their diffusive Pb-closure temperature, along fractures. The extent of fluid alteration is seen clearly in back-scattered electron images and Zr-, Al-, Fe-, Ce-, and Nb-concentration maps. Laser-ablation depth profiling of idioblastic titanite grains shows preserved Pb diffusion profiles at grain rims, but there is no evidence for Zr diffusion, indicating that it was effectively immobile even at UHT.

  13. 76 FR 2897 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-18

    ... Assignment, Contenancy and Common Facilities Agreement with Succession to be effective 10/14/2010. Filed Date... Energy LLC submits tariff filing per 35: Amendment to Market-Based Rate Tariff 01062011 to be effective 1... Succession to be effective 2/9/2011. Filed Date: 01/06/2011. Accession Number: 20110106-5096. Comment Date: 5...

  14. Students with No-Contact Orders against Abusive Classmates: Recommendations for Educators

    ERIC Educational Resources Information Center

    Mayes, Thomas A.

    2008-01-01

    Teen dating violence is a common and often overlooked problem in schools. The consequences of teen dating violence often include decreased academic achievement and increased risk for school failure. The law may provide relief for targets of teen dating violence, including granting orders of protection (no-contact orders) against their…

  15. 26 CFR 1.1033(h)-1 - Effective date.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Effective date. 1.1033(h)-1 Section 1.1033(h)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Common Nontaxable Exchanges § 1.1033(h)-1 Effective date. Except as provided otherwise in...

  16. 76 FR 77831 - 2012 Presidential Candidate Matching Fund Submission Dates and Post Date of Ineligibility Dates...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-14

    ... statement'') after their dates of ineligibility (``DOI''). Candidates are required to submit a NOCO... notified of their DOI by the Commission. A Candidate who has net outstanding campaign obligations post-DOI... each matching fund request submitted after the candidate's DOI. These statements are due just before...

  17. Date palm status and perspective in the United States

    USDA-ARS?s Scientific Manuscript database

    The date industry in the United States is small in comparison with that of many other date-producing countries. The US does not have any indigenous date palm (Phoneix dactylifera L) germplasm, so the industry developed using imported varieties in the early years of the 20th century. Due to its speci...

  18. 78 FR 28208 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...) to be effective 5/1/2013. Filed Date: 4/30/13. Accession Number: 20130430-5118. Comments Due: 5 p.m... Partners--2013 to be effective 5/1/2013. Filed Date: 4/30/13. Accession Number: 20130430-5125. Comments Due...

  19. 77 FR 1926 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-12

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... Auburndale Peaker Energy Center, LLC et al. Filed Date: 1/3/12. Accession Number: 20120103-5297. Comments Due..., et al. Filed Date: 1/3/12. Accession Number: 20120103-5294. Comments Due: 5 p.m. ET 3/5/12. Docket...

  20. 42 CFR 488.442 - Civil money penalties: Due date for payment of penalty.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Civil money penalties: Due date for payment of penalty. 488.442 Section 488.442 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... PROCEDURES Enforcement of Compliance for Long-Term Care Facilities with Deficiencies § 488.442 Civil money...

  1. 42 CFR 488.442 - Civil money penalties: Due date for payment of penalty.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Civil money penalties: Due date for payment of penalty. 488.442 Section 488.442 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... PROCEDURES Enforcement of Compliance for Long-Term Care Facilities with Deficiencies § 488.442 Civil money...

  2. 42 CFR 488.442 - Civil money penalties: Due date for payment of penalty.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Civil money penalties: Due date for payment of penalty. 488.442 Section 488.442 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... PROCEDURES Enforcement of Compliance for Long-Term Care Facilities with Deficiencies § 488.442 Civil money...

  3. 42 CFR 488.442 - Civil money penalties: Due date for payment of penalty.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Civil money penalties: Due date for payment of penalty. 488.442 Section 488.442 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... PROCEDURES Enforcement of Compliance for Long-Term Care Facilities with Deficiencies § 488.442 Civil money...

  4. 42 CFR 488.442 - Civil money penalties: Due date for payment of penalty.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Civil money penalties: Due date for payment of penalty. 488.442 Section 488.442 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF... PROCEDURES Enforcement of Compliance for Long-Term Care Facilities with Deficiencies § 488.442 Civil money...

  5. 77 FR 34034 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-08

    ... Report. Filed Date: 5/24/12. Accession Number: 20120524-5201. Comments Due: 5 p.m. ET 6/5/12. Docket Numbers: RP12-751-000. Applicants: Big Sandy Pipeline, LLC. Description: Negotiated Rates May 2012 Cleanup to be effective 6/ 25/2012. Filed Date: 5/25/12. Accession Number: 20120525-5030. Comments Due: 5 p.m...

  6. 78 FR 9983 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... Due to Extraordinary Market Volatility February 6, 2013. Pursuant to Section 19(b)(1) of the... securities due to extraordinary market volatility, to extend the effective date of the pilot by which such... initial date of operations of the Regulation NMS Plan to Address Extraordinary Market Volatility or...

  7. 34 CFR 682.405 - Loan rehabilitation agreement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... first required due date falls and ends with the ninth consecutive calendar month following that month... that begins with the month in which the first required due date falls and ends with the ninth... guaranty agency); and (3) A statement of the unpaid balance on all FFEL loans held by other holders. (iv...

  8. 21 CFR 1309.45 - Extension of registration pending final order.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... final order. In the event that an applicant for reregistration (who is doing business under a... before the date on which the existing registration is due to expire, and the Administrator has issued no order on the application on the date on which the existing registration is due to expire, the existing...

  9. Germination, genetics, and growth of an ancient date seed.

    PubMed

    Sallon, Sarah; Solowey, Elaine; Cohen, Yuval; Korchinsky, Raia; Egli, Markus; Woodhatch, Ivan; Simchoni, Orit; Kislev, Mordechai

    2008-06-13

    An ancient date seed (Phoenix dactylifera L.) excavated from Masada and radiocarbon-dated to the first century Common Era was germinated. Climatic conditions at the Dead Sea may have contributed to the longevity of this oldest, directly dated, viable seed. Growth and development of the seedling over 26 months was compatible with normal date seedlings propagated from modern seeds. Preliminary molecular characterization demonstrated high levels of genetic variation in comparison to modern, elite date cultivars currently growing in Israel. As a representative of an extinct date palm population, this seedling can provide insights into the historic date culture of the Dead Sea region. It also has importance for seed banking and conservation and may be of relevance to modern date palm cultivation.

  10. Challenges and Driving Forces for Business Plans in Biobanking.

    PubMed

    Macheiner, Tanja; Huppertz, Berthold; Bayer, Michaela; Sargsyan, Karine

    2017-04-01

    Due to increased utilization of biospecimens for research and emergence of new technologies, the availability and quality of biospecimens and their collection are coming more and more into focus. However, the long-term economic situation of biobanks is still mostly unclear. Also, the common sustainable utilization of various international biobanks is challenging due to local differences in sample processing, law and ethics. This article discusses possible strategies to achieve a sustainable utilization of biospecimens as part of the business plan of biobanks. The following questions were addressed as part of a business plan: (1) How can a biobank build up and maintain an up-to-date infrastructure? (2) What kind of funding can support the sustainability of a biobank? (3) Is there an international solution for informed consents to enable sample and data sharing? (4) How can a biobank react during economically unstable periods? (5) Which kind of biobanking research is innovative? (6) What kind of education could be most needful for knowledge transfer in biobanking? (7) Does an expiration date for a biobank make sense according to the period of funding? A strategy for optimal utilization begins with sharing of resources, infrastructure, and investments at the planning stage of a biobank, and continues to the transfer of knowledge and know-how by education. For clinical biobanks in particular, a long-term funding and cost recovery strategy is necessary for sustainable utilization.

  11. Choosing a calving date

    USDA-ARS?s Scientific Manuscript database

    Calving date affects cost and timing of production events. Due to the polyestrous nature of beef females, producers can choose a calving date that fits their production system and geographic region. Any time an entire production system is considered, decision making becomes complex. Any calving syst...

  12. 77 FR 28592 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-15

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... be effective 3/1/2012. Filed Date: 5/7/12. Accession Number: 20120507-5119. Comments Due: 5 p.m. ET 5... effective 6/1/2012. Filed Date: 5/8/12. Accession Number: 20120508-5039. Comments Due: 5 p.m. ET 5/29/12...

  13. 78 FR 8120 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... Hills Wind, LLC. Filed Date: 1/28/13. Accession Number: 20130128-5245. Comments Due: 5 p.m. ET 2/19/13... APDC, Inc., et al. Filed Date: 1/28/13. Accession Number: 20130128-5273. Comments Due: 5 p.m. ET 2/19...

  14. 25 CFR 171.100 - What are some of the terms I should know for this part?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...). Due date means the date printed on your bill, 30 days after which your bill becomes past due. Facility... supports irrigated agriculture, livestock, Carriage Agreements or other uses defined by laws, regulations... Indian Affairs within the United States Department of the Interior. Bill means our statement to you of...

  15. 25 CFR 171.100 - What are some of the terms I should know for this part?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...). Due date means the date printed on your bill, 30 days after which your bill becomes past due. Facility... supports irrigated agriculture, livestock, Carriage Agreements or other uses defined by laws, regulations... Indian Affairs within the United States Department of the Interior. Bill means our statement to you of...

  16. 25 CFR 171.100 - What are some of the terms I should know for this part?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...). Due date means the date printed on your bill, 30 days after which your bill becomes past due. Facility... supports irrigated agriculture, livestock, Carriage Agreements or other uses defined by laws, regulations... Indian Affairs within the United States Department of the Interior. Bill means our statement to you of...

  17. 77 FR 47140 - Self-Regulatory Organizations; NYSE MKT LLC; Notice of Filing and Immediate Effectiveness of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-07

    ... Extraordinary Market Volatility, To Extend the Effective Date of the Pilot, Until February 4, 2013 August 1...--Equities, which provides for trading pauses in individual securities due to extraordinary market volatility... securities due to extraordinary market volatility, to extend the effective date of the pilot by which such...

  18. 43 CFR 3830.24 - How do I make payments?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... or before the due date. (b) If you use a credit card— (1) On or before the due date, you must send or fax a written authorization, bearing your signature; or (2) You may authorize BLM to use your credit card by telephone if you can satisfactorily establish your identity. (c) You may send payments using a...

  19. 43 CFR 3830.24 - How do I make payments?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... or before the due date. (b) If you use a credit card— (1) On or before the due date, you must send or fax a written authorization, bearing your signature; or (2) You may authorize BLM to use your credit card by telephone if you can satisfactorily establish your identity. (c) You may send payments using a...

  20. 43 CFR 3830.24 - How do I make payments?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... or before the due date. (b) If you use a credit card— (1) On or before the due date, you must send or fax a written authorization, bearing your signature; or (2) You may authorize BLM to use your credit card by telephone if you can satisfactorily establish your identity. (c) You may send payments using a...

  1. 43 CFR 3830.24 - How do I make payments?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... or before the due date. (b) If you use a credit card— (1) On or before the due date, you must send or fax a written authorization, bearing your signature; or (2) You may authorize BLM to use your credit card by telephone if you can satisfactorily establish your identity. (c) You may send payments using a...

  2. 40 CFR Table 1 to Subpart B of... - Section 112(j) Part 2 Application Due Dates

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Section 112(j) Part 2 Application Due Dates 1 Table 1 to Subpart B of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... CATEGORIES Requirements for Control Technology Determinations for Major Sources in Accordance With Clean Air...

  3. Late Pleistocene Megafaunal Extinction Consistent With YDB Impact Hypothesis at Younger Dryas Onset

    NASA Astrophysics Data System (ADS)

    Kennett, J. P.; Kennett, D. J.

    2008-12-01

    At least 35 mammal and 19 bird genera became extinct across North America near the end of the Pleistocene. Modern increases in stratigraphic and dating resolution suggest that this extinction occurred relatively rapidly near 12.9 ka (11 radiocarbon kyrs). Within the context of a long-standing debate about its cause, Firestone et al., (2007) proposed that this extinction resulted from an extraterrestrial (ET) impact over North America at 12.9 ka. This hypothesis predicts that the extinction of most of these animals should have occurred abruptly at 12.9 ka. To test this hypothesis, we have critically examined radiocarbon ages and the extinction stratigraphy of these taxa. From a large data pool, we selected only radiocarbon dates with low error margins with a preference for directly dated biological materials (e.g., bone, dung, etc.) and modern chemical purification techniques. A relatively small number of acceptable dates indicate that at least 16 animal genera and several other species became extinct close to 12.9 ka. These taxa include the most common animals of the late Pleistocene such as horses, camels, and mammoths. Also, the remains of extinct taxa are reportedly found up to, but not above, the base of a widely distributed carbon-rich layer called the black mat. This stratum forms an abrupt, major biostratigraphic boundary at the Younger Dryas onset (12.9 ka), which also contains multiple ET markers comprising the impact layer (the YDB). Surviving animal populations were abruptly reduced at the YDB (e.g., Bison), with major range restrictions and apparent evolutionary bottlenecks. The abruptness of this major extinction is inconsistent with the hypotheses of human overkill and climatic change. We argue that extinction ages older than 12.9 ka for many less common species result from the Signor-Lipps effect, but the impact hypothesis predicts that as new dates are acquired, they will approach ever closer to 12.9 ka. The megafaunal extinction is strongly associated with abrupt and major vegetation changes, abrupt cooling, and widespread biomass burning at the onset of the Younger Dryas over North America. The stratigraphic and chronologic data are consistent with megafaunal extinction being caused by continental-scale ecosystem disruption due to an ET impact.

  4. Constraining recent Shiveluch volcano eruptions (Kamchatka, Russia) by means of dendrochronology

    NASA Astrophysics Data System (ADS)

    Solomina, O.; Pavlova, I.; Curtis, A.; Jacoby, G.; Ponomareva, V.; Pevzner, M.

    2008-10-01

    Shiveluch (N 56°38´, E 161°19´; elevation: active dome ~2500 m, summit of Old Shiveluch 3283 m) is one of the most active volcanoes in Kamchatka. The eruptions of Shiveluch commonly result in major environmental damage caused by debris avalanches, hot pyroclastic flows, tephra falls and lahars. Constraining these events in time and space is important for the understanding and prediction of these natural hazards. The last major eruption of Shiveluch occurred in 2005; earlier ones, dated by instrumental, historical, 14C and tephrochronological methods, occurred in the last millennium around AD 1030, 1430, 1650, 1739, 1790 1810, 1854, 1879 1883, 1897 1898, 1905, 1927 1929, 1944 1950, and 1964. A lava dome has been growing in the 1964 crater since 1980, occasionally producing tephra falls and pyroclastic flows. Several Shiveluch eruptions (~AD 1050, 1650, 1854, 1964) may have been climatically effective and are probably recorded in the Greenland ice cores. Previously, most dates for eruptions before AD 1854 were obtained by tephrochronology and constrained by radiocarbon dating with an accuracy of several decades or centuries. In this paper we report tree-ring dates for a recent pyroclastic flow in Baidarnaia valley. Though the wood buried in these deposits is carbonized, fragile and poorly preserved, we were able to measure ring-width using standard tree-ring equipment or photographs and to cross-date these samples against the regional Kamchatka larch ring-width chronology. The dates of the outer rings indicate the date of the eruptions. In the Baidarnaia valley the eruption occurred shortly after AD 1756, but not later than AD 1758. This date coincides with the decrease of ring-width in trees growing near Shiveluch volcano in 1758 1763 in comparison with the control "non-volcanic" chronology. The pyroclastic flow in Kamenskaia valley, although similar in appearance to the one in Baidarnaia valley, definitively yielded a different age. Due to the age limit of the reference chronology (AD 1632 2005) and its short overlap with the sample chronology in Kamenskaia valley the dates of these deposits are very preliminary. The deposits probably date back to approximately AD 1649 or a few years later. This date is in close agreement with the previously obtained radiocarbon date of these sediments to AD 1641(1652)1663. Our data agree well with the tephrochronological findings, and further constrain the chronology of volcanic events in this remote area.

  5. Effects of egg size, parental quality and hatch-date on growth and survival of Common Tern Sterna hirundo chicks

    USGS Publications Warehouse

    Arnold, J.M.; Hatch, J.J.; Nisbet, I.C.T.

    2006-01-01

    We examined the relative contributions of egg size, parental quality and hatch-date to growth and survival of second-hatched chicks (those chicks making the greatest contribution to differences in productivity among pairs) by exchanging clutches among nests of Common Terns Sterna hirundo matched for lay-date (range 13 May to 9 June). The mass of a second-laid egg in an exchanged clutch ranged from 17.70 to 23.80 g. Growth and survival were studied during three periods: early (days 0-3), middle (days 3-12) and late (days 12-25). Both egg mass and hatch-date were important predictors of hatchling mass (positive relationships), although there was no seasonal trend in egg mass. During the middle period, hatch-date was a significant predictor of mass gain and survival (inverse relationships). After controlling for hatch-date, other indices of parental quality made only small contributions to chick mass gain and survival. Our results suggest that although breeding early generally leads to greater overall survival of chicks, several important interactions among egg 'quality', parental quality and early laying may affect breeding success under specific conditions. ?? 2006 British Ornithologists' Union.

  6. Assessment of rat optic nerve damage due to microbeam radiation therapy in the treatment of glioblastomas.

    PubMed

    Mohamed, A; Worobec, S; Schultke, E

    2008-01-01

    Glioblastomas are the most common and aggressive subtype of human primary brain tumors. Due to their uncontrolled cellular proliferation, intense invasion, and lack of apoptosis, they are extremely difficult to treat. Currently, different approaches such as surgery, chemotherapy and radiation therapy have been employed as possible treatments however thus far; these treatments are not curative. Currently, microbeam radiation therapy (MRT) is being trialed in animal models of malignant brain tumors (rats) to aid in treatment. Some of the protocols tested have been shown to significantly increase survival rates. However, due to the high x-ray doses uses in MRT, the surrounding tissue of the targeted Glioblastomas may be irreversibly damaged. In previous studies, lens damage and clouding of the cornea have been observed in microbeam exposed eyes. However, to date no studies have assessed optic nerve damage. Therefore, this study examines the potential rat optic nerve damage following exposure to microbeam radiation therapy in the treatment of Glioblastomas. Although there appears to be no significant damage to the optic nerve, slight inflammation was observed within the extra ocular muscle.

  7. ESR dating pleistocene barnacles from BC and Maine: a new method for tracking sea level change.

    PubMed

    Blackwell, Bonnie A B; Gong, J J J; Skinner, Anne R; Blais-Stevens, Andrée; Nelson, Robert E; Blickstein, Joel I B

    2010-02-01

    Barnacles have never been successfully dated by electron spin resonance (ESR). Living mainly in the intertidal zone, barnacles die when sea level changes cause their permanent exposure. Thus, dating the barnacles dates past sea level changes. From this, we can measure apparent sea level changes that occur due to ocean volume changes, crustal isostasy, and tectonics. ESR can date aragonitic mollusc shells ranging in age from 5 ka to at least 500 ka. By modifying the standard ESR method for molluscs to chemically dissolve 20 microm from off the shells, six barnacle samples from Norridgewock, Maine, and Khyex River, British Columbia, were tested for suitability for ESR dating. Due to Mn2+ interference peaks, the four Maine barnacle samples were not datable by ESR. Two barnacles from BC, which lacked Mn2+ interference, yielded a mean ESR age of 15.1 +/- 1.0 ka. These ages agree well with 14C dates on the barnacles themselves and wood in the overlying glaciomarine sediment. Although stability tests to calculate the mean dating signal lifetime and more ESR calibration tests against other barnacles of known age are needed to ensure the method's accuracy, ESR can indeed date Balanus, and thus, sea level changes.

  8. Metabolomics in amyotrophic lateral sclerosis: how far can it take us?

    PubMed

    Blasco, H; Patin, F; Madji Hounoum, B; Gordon, P H; Vourc'h, P; Andres, C R; Corcia, P

    2016-03-01

    Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease. Alongside identification of aetiologies, development of biomarkers is a foremost research priority. Metabolomics is one promising approach that is being utilized in the search for diagnosis and prognosis markers. Our aim is to provide an overview of the principal research in metabolomics applied to ALS. References were identified using PubMed with the terms 'metabolomics' or 'metabolomic' and 'ALS' or 'amyotrophic lateral sclerosis' or 'MND' or 'motor neuron disorders'. To date, nine articles have reported metabolomics research in patients and a few additional studies examined disease physiology and drug effects in patients or models. Metabolomics contribute to a better understanding of ALS pathophysiology but, to date, no biomarker has been validated for diagnosis, principally due to the heterogeneity of the disease and the absence of applied standardized methodology for biomarker discovery. A consensus on best metabolomics methodology as well as systematic independent validation will be an important accomplishment on the path to identifying the long-awaited biomarkers for ALS and to improve clinical trial designs. © 2016 EAN.

  9. Gene Therapy for Color Blindness.

    PubMed

    Hassall, Mark M; Barnard, Alun R; MacLaren, Robert E

    2017-12-01

    Achromatopsia is a rare congenital cause of vision loss due to isolated cone photoreceptor dysfunction. The most common underlying genetic mutations are autosomal recessive changes in CNGA3 , CNGB3 , GNAT2 , PDE6H , PDE6C , or ATF6 . Animal models of Cnga3 , Cngb3 , and Gnat2 have been rescued using AAV gene therapy; showing partial restoration of cone electrophysiology and integration of this new photopic vision in reflexive and behavioral visual tests. Three gene therapy phase I/II trials are currently being conducted in human patients in the USA, the UK, and Germany. This review details the AAV gene therapy treatments of achromatopsia to date. We also present novel data showing rescue of a Cnga3 -/- mouse model using an rAAV.CBA.CNGA3 vector. We conclude by synthesizing the implications of this animal work for ongoing human trials, particularly, the challenge of restoring integrated cone retinofugal pathways in an adult visual system. The evidence to date suggests that gene therapy for achromatopsia will need to be applied early in childhood to be effective.

  10. Identification of the date-rape drug GHB and its precursor GBL by Raman spectroscopy.

    PubMed

    Brewster, Victoria L; Edwards, Howell G M; Hargreaves, Michael D; Munshi, Tasnim

    2009-01-01

    Gamma hydroxybutyric acid (GHB), also known as 'liquid ecstasy', has recently become associated with drug-facilitated sexual assaults, known colloquially as 'date rape', due to the ability of the drug to cause loss of consciousness. The drug is commonly found 'spiked' into alcoholic beverages, as alcohol increases its sedative effects. Gamma hydroxybutyric acid and the corresponding lactone gamma-butyrolactone (GBL) will reach an equilibrium in solution which favours the lactone in basic conditions and GHB in acidic conditions (less than pH 4). Therefore, we have studied both GHB and GBL, as a mildly acidic beverage 'spiked' with GHB will contain both GHB and GBL. We report the analysis of GHB as a sodium salt and GBL, its precursor, using bench-top and portable Raman spectroscopy. It has been demonstrated that we are able to detect GHB and GBL in a variety of containers including colourless and amber glass vials, plastic vials and polythene bags. We have also demonstrated the ability to detect both GBL and GHB in a range of liquid matrices simulating 'spiked' beverages. (c) 2009 John Wiley & Sons, Ltd.

  11. A French hernia in Dubai: A case report.

    PubMed

    Al Abboudi, Yousif H; Busharar, Hajer A; Alozaibi, Labib S; Shah, Asnin; Ahmed, Rafya

    2018-05-31

    De Garengeot hernia was first described in 1731. It is rare type of hernia and there is no established mode of treatment for it to date. This work has been reported in line with the SCARE criteria (Agha et al., 2016). We present a case of a 72 years old male with a non-reducible right inguinal swelling diagnosed to be a femoral hernia with congested appendix within. There are less than 100 cases like this reported to date in the literature. Acute appendicitis within the femoral hernia is not a common problem to cross paths with. Prompt early treatment is recommended and directed at repairing the hernia after appendectomy. The method of treatment is controversial and not well established due to the scarcity of cases but open repair without mesh is the preferred approach. De Garengeot hernia is a rare hernia to encounter. Imaging modalities are a major tool in early diagnosis and early prompt surgery is crucial in preventing major complications that may lead to unnecessary morbidity and mortality. Copyright © 2018. Published by Elsevier Ltd.

  12. 78 FR 23766 - Proposed Data Collections Submitted for Extension of Public Comment Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-22

    ... (HHS), is reopening the comment period, thus amending the due date for responses to its Request for Public Comments, published in Vol. 78, No. 29, of the Federal Register on February 12, 2013. The due date... proposed project or to obtain a copy of the data collection plans and instruments, call 404-639-7570 or...

  13. When the Due Date Is Not the "Do" Date!

    ERIC Educational Resources Information Center

    Mastrianni, Theresa M.

    2015-01-01

    Our students consistently hand in assignments late, or complete them at the last minute. Why is it that they know about assignments all term long yet only begin them the night before the assignment is due? Based on a career-focused learning community at Kingsborough Community College of the City University of New York, this article looks at ways…

  14. Exploring the Possibility for a Common System for Joint Aeromedical Standards

    DTIC Science & Technology

    2011-01-01

    CRoSSRoAdS MJM 2011 13( 2 ): 82-9282 Copyright © 2011 by MJM *To whom correspondence should be addressed: Dr. Justin Woodson LTC, MC, SFS, US Army...Vol. 13 No. 2 Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of information is estimated to...REPORT DATE 2011 2 . REPORT TYPE 3. DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE Exploring The Possibility For A Common System

  15. An evaluation of complementary approaches to elucidate fundamental interfacial phenomena driving adhesion of energetic materials

    DOE PAGES

    Hoss, Darby J.; Knepper, Robert; Hotchkiss, Peter J.; ...

    2016-03-23

    In this study, cohesive Hamaker constants of solid materials are measured via optical and dielectric properties (i.e., Lifshitz theory), inverse gas chromatography (IGC), and contact angle measurements. To date, however, a comparison across these measurement techniques for common energetic materials has not been reported. This has been due to the inability of the community to produce samples of energetic materials that are readily compatible with contact angle measurements. Here we overcome this limitation by using physical vapor deposition to produce thin films of five common energetic materials, and the contact angle measurement approach is applied to estimate the cohesive Hamakermore » constants and surface energy components of the materials. The cohesive Hamaker constants range from 85 zJ to 135 zJ across the different films. When these Hamaker constants are compared to prior work using Lifshitz theory and nonpolar probe IGC, the relative magnitudes can be ordered as follows: contact angle > Lifshitz > IGC. Furthermore, the dispersive surface energy components estimated here are in good agreement with those estimated by IGC. Due to these results, researchers and technologists will now have access to a comprehensive database of adhesion constants which describe the behavior of these energetic materials over a range of settings.« less

  16. 75 FR 32343 - Debt Collection and Administrative Offset for Monies Due the Federal Government

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-08

    ... clarify 31 CFR 901.9(b)(1), which specifies that ``[i]nterest shall accrue from the date of delinquency... penalty of 6 percent on any delinquent debt that is more than 90 days from the date of delinquency that it... penalty would accrue from the date of delinquency through the date MMS refers the debt to Treasury. It is...

  17. Dating and eating. Beliefs about dating foods among university students.

    PubMed

    Amiraian, Dana E; Sobal, Jeffery

    2009-10-01

    Dating is an important courtship activity in the U.S., and food consumption is part of dating events. Students use dating scripts to guide decisions and behaviors on dates, and perform scripts on dates to construct positive impression management. This study examined how students conceptualized dating foods. A questionnaire was administered in one large university class, and data from 301 students were analyzed. Students were asked to name three dating foods, three foods that are not dating foods, what makes foods dating foods, and what makes foods not dating foods. Findings revealed that both common and uncommon foods were named as dating and not dating foods. Alcoholic beverages were sometimes named as dating foods. Women often named feminine foods (considered appropriate for females) as dating foods, but men were not more likely to name masculine foods (considered appropriate for males) as dating foods. Neat and easy-to-eat foods were often named as dating foods, while pungent foods and foods causing bad breath were named as not dating foods. These findings support the conception that dating scripts guide thinking about food choices to enhance impression management. Dating food choices are important for current health and as potential precursors for long-term eating relationships like marriage.

  18. Vaccines for the common cold.

    PubMed

    Simancas-Racines, Daniel; Franco, Juan Va; Guerra, Claudia V; Felix, Maria L; Hidalgo, Ricardo; Martinez-Zapata, Maria José

    2017-05-18

    The common cold is a spontaneously remitting infection of the upper respiratory tract, characterised by a runny nose, nasal congestion, sneezing, cough, malaise, sore throat, and fever (usually < 37.8º C). The widespread morbidity caused by the common cold worldwide is related to its ubiquitousness rather than its severity. The development of vaccines for the common cold has been difficult because of antigenic variability of the common cold virus and the indistinguishable multiple other viruses and even bacteria acting as infective agents. There is uncertainty regarding the efficacy and safety of interventions for preventing the common cold in healthy people. This is an update of a Cochrane review first published in 2011 and previously updated in 2013. To assess the clinical effectiveness and safety of vaccines for preventing the common cold in healthy people. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (September 2016), MEDLINE (1948 to September 2016), Embase (1974 to September 2016), CINAHL (1981 to September 2016), and LILACS (1982 to September 2016). We also searched three trials registers for ongoing studies and four websites for additional trials (February 2017). We included no language or date restrictions. Randomised controlled trials (RCTs) of any virus vaccines compared with placebo to prevent the common cold in healthy people. Two review authors independently evaluated methodological quality and extracted trial data. We resolved disagreements by discussion or by consulting a third review author. We found no additional RCTs for inclusion in this update. This review includes one RCT dating from the 1960s with an overall high risk of bias. The RCT included 2307 healthy participants, all of whom were included in analyses. This trial compared the effect of an adenovirus vaccine against placebo. No statistically significant difference in common cold incidence was found: there were 13 (1.14%) events in 1139 participants in the vaccines group and 14 (1.19%) events in 1168 participants in the placebo group (risk ratio 0.95, 95% confidence interval 0.45 to 2.02; P = 0.90). No adverse events related to the live vaccine were reported. The quality of the evidence was low due to limitations in methodological quality and a wide 95% confidence interval. This Cochrane Review was based on one study with low-quality evidence. We found no conclusive results to support the use of vaccines for preventing the common cold in healthy people compared with placebo. We identified a need for well-designed, adequately powered RCTs to investigate vaccines for the common cold in healthy people. Any future trials on medical treatments for preventing the common cold should assess a variety of virus vaccines for this condition. Outcome measures should include common cold incidence, vaccine safety, and mortality related to the vaccine.

  19. Identity, Intimacy, Status and Sex Dating Goals as Correlates of Goal-Consistent Behavior and Satisfaction in Australian Youth

    ERIC Educational Resources Information Center

    Kelly, Marguerite; Zimmer-Gembeck, Melanie J.; Boislard-P., Marie-Aude

    2012-01-01

    The most common dating goals of adolescents are identity, intimacy, status and sex. In this study of Australian youth (16-30 years, N = 208), dating goals were expected to explain goal-consistent behavior in each domain. Also, goals coupled with consistent behavior were expected to be associated with greater satisfaction in each domain. Age,…

  20. Sleep-Wake Cycle and Daytime Sleepiness in the Myotonic Dystrophies

    PubMed Central

    Romigi, A.; Albanese, M.; Liguori, C.; Placidi, F.; Marciani, M. G.; Massa, R.

    2013-01-01

    Myotonic dystrophy is the most common type of muscular dystrophy in adults and is characterized by progressive myopathy, myotonia, and multiorgan involvement. Two genetically distinct entities have been identified, myotonic dystrophy type 1 (DM1 or Steinert's Disease) and myotonic dystrophy type 2 (DM2). Myotonic dystrophies are strongly associated with sleep dysfunction. Sleep disturbances in DM1 are common and include sleep-disordered breathing (SDB), periodic limb movements (PLMS), central hypersomnia, and REM sleep dysregulation (high REM density and narcoleptic-like phenotype). Interestingly, drowsiness in DM1 seems to be due to a central dysfunction of sleep-wake regulation more than SDB. To date, little is known regarding the occurrence of sleep disorders in DM2. SDB (obstructive and central apnoea), REM sleep without atonia, and restless legs syndrome have been described. Further polysomnographic, controlled studies are strongly needed, particularly in DM2, in order to clarify the role of sleep disorders in the myotonic dystrophies. PMID:26316996

  1. New methodology for dynamic lot dispatching

    NASA Astrophysics Data System (ADS)

    Tai, Wei-Herng; Wang, Jiann-Kwang; Lin, Kuo-Cheng; Hsu, Yi-Chin

    1994-09-01

    This paper presents a new dynamic dispatching rule to improve delivery. The dynamic dispatching rule named `SLACK and OTD (on time delivery)' is developed for focusing on due date and target cycle time under the environment of IC manufacturing. This idea uses traditional SLACK policy to control long term due date and new OTD policy to reflect the short term stage queue time. Through the fuzzy theory, these two policies are combined as the dispatching controller to define the lot priority in the entire production line. Besides, the system would automatically update the lot priority according to the current line situation. Since the wafer dispatching used to be controlled by critical ratio that indicates the low customer satisfaction. And the overall slack time in the front end of the process is greater compared to that in the rear end of the process which reveals that the machines in the rear end are overloaded by rush orders. When SLACK and OTD are used the due date control has been gradually improved. The wafer with either a long stage queue time or urgent due date will be pushed through the overall production line instead of jammed in the front end. A demand pull system is also developed to satisfy not only due date but also the quantity of monthly demand. The SLACK and OTD rule has been implemented in Taiwan Semiconductor Manufacturing Company for eight months with beneficial results. In order to clearly monitor the SLACK and OTD policy, a method called box chart is generated to simulate the entire production system. From the box chart, we can not only monitor the result of decision policy but display the production situation on the density figure. The production cycle time and delivery situation can also be investigated.

  2. Associations between birth at, or after, 41 weeks gestation and perinatal encephalopathy: a cohort study

    PubMed Central

    Yau, Christopher; Winter, Cathy; Draycott, Timothy; Rasmussen, Finn

    2018-01-01

    Background Preterm birth causes long-term problems, even for infants born 1 or 2 weeks early. However, less is known about infants born after their due date and over a quarter of infants are born over 1 week late, and many still remain undelivered after 2 weeks. The aim of this work is to quantify the risks of infants developing encephalopathy when birth occurs after the due date, and if other proposed risk factors modify this relationship. Methods The dataset contain information on 4 036 346 infants born in Sweden between 1973 and 2012. Exposure was defined as birth 7, or more, days after the infants’ due date. The primary outcome was the development of neonatal encephalopathy (defined as seizures, encephalopathy or brain injury caused by asphyxia or with unspecified cause). Covariates were selected as presumed confounders a priori. Results 28.4% infants were born 1 or more weeks after their due date. An infant’s risk of being born with encephalopathy was higher in the post 41 weeks group in the unadjusted (OR 1.40 (95% CI 1.32 to 1.49)) and final model (OR 1.38 (95% CI 1.29 to 1.47)), with the relative odds of encephalopathy increasing by an estimated 20% per week after the due date, and modified by maternal age (P=0.022). Conclusions Singleton infants born at, or after, 41 weeks gestation have lower Apgar scores and higher risk of developing encephalopathy in the newborn period, and the association appeared more marked in older mothers. These data could be useful if provided to women as part of their decision-making. PMID:29637179

  3. 78 FR 19475 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-01

    ... Succession to be effective 3/21/2013. Filed Date: 3/21/13. Accession Number: 20130321-5055. Comments Due: 5 p.... Description: Notice of Succession to be effective 3/21/2013. Filed Date: 3/21/13. Accession Number: 20130321..., LLC. Description: Notice of Succession to be effective 3/21/2013. Filed Date: 3/21/13. Accession...

  4. 77 FR 38734 - Defense Federal Acquisition Regulation Supplement; Acquisition of Tents and Other Temporary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ... Structures (DFARS Case 2012-D015) AGENCY: Defense Acquisition Regulations System, Department of Defense (DoD... structures. DATES: Effective date: June 29, 2012. Comment date: Comments are due by August 28, 2012..., when acquiring tents and other temporary structures, regardless of whether purchased by DoD or by...

  5. 77 FR 37396 - Combined Notice of Filings #2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ... Lynch Commodities, Inc. Filed Date: 6/13/12. Accession Number: 20120613-5053. Comments Due: 5 p.m. ET 7..., Inc. Description: 6-13-12 Schedule 20 Compliance to be effective 5/15/ 2012. Filed Date: 6/13/12...: Casselman Windpower LLC. Description: Tariff Revisions to be effective 6/14/2012. Filed Date: 6/13/12...

  6. Bioethanol production from renewable sources as alternative valorization of waste of starting dates in south Algeria

    NASA Astrophysics Data System (ADS)

    Mehani, Insaf; Bouchekima, Bachir

    2018-05-01

    The necessary reduction and progressive consumption of fossil fuels, whose scarcity is inevitable, involves mobilizing a set of alternatives. Renewable energy, including bio energy is an alternative to the depletion of fossil fuels and a way to fight against the harmful effects of pollution that undergoes the environment. In Algeria, the conditioning units of dates generate significant quantities of waste arising from sorting deviations. This biomass, until then considered as a waste with high impact on the environment can be transformed into high value added product. It is possible to develop common dates of low commercial value, and put on the local and international market a new generation of products with high added values such as bio ethanol. Besides its use in chemical synthesis, bio ethanol can be blended with gasoline to produce a clean fuel while improving the octane. The objective of the present work is to study the feasibility and productivity of generating bio ethanol in laboratory from the transformation of common date using anaerobic fermentation and distillation processes. After an alcoholic fermentation of the substrate of the date using bakery yeast at 30°C for 72 h, the distilled and rectified date juice generated the highest ethanol 88° with acceptable productions.

  7. Primary thyroid leiomyosarcoma: a case report and review of the literature

    PubMed Central

    CANU, G.L.; BULLA, J.S.; LAI, M.L.; MEDAS, F.; BAGHINO, G.; ERDAS, E.; MARIOTTI, S.

    2018-01-01

    Primary thyroid leiomyosarcoma (LMS) is an extremely rare tumor. We report a case of a 47-year-old male with a rapidly growing neck mass and disfagia. Preoperative investigations were diagnostic of anaplastic carcinoma. Total thyroidectomy with partial esophagectomy and dissection of right infrahyoid muscles was performed. Through histolological and immunohistochemical evaluations a primary thyroid high-grade LMS was diagnosed. At 2 months of follow-up a local recurrence was detected and consequently the patient was submitted to chemotherapy with partial response. He is still alive 9 months after surgery. Diagnosis of primary thyroid LMS is difficult due to its similarity to other more common thyroid tumors. To date, there is no standard therapy and prognosis is poor. PMID:29549682

  8. Primary thyroid leiomyosarcoma: a case report and review of the literature.

    PubMed

    Canu, G L; Bulla, J S; Lai, M L; Medas, F; Baghino, G; Erdas, E; Mariotti, S; Calò, P G

    2018-01-01

    Primary thyroid leiomyosarcoma (LMS) is an extremely rare tumor. We report a case of a 47-year-old male with a rapidly growing neck mass and disfagia. Preoperative investigations were diagnostic of anaplastic carcinoma. Total thyroidectomy with partial esophagectomy and dissection of right infrahyoid muscles was performed. Through histolological and immunohistochemical evaluations a primary thyroid high-grade LMS was diagnosed. At 2 months of follow-up a local recurrence was detected and consequently the patient was submitted to chemotherapy with partial response. He is still alive 9 months after surgery. Diagnosis of primary thyroid LMS is difficult due to its similarity to other more common thyroid tumors. To date, there is no standard therapy and prognosis is poor.

  9. Measuring the impostor phenomenon: a comparison of Clance's IP Scale and Harvey's I-P Scale.

    PubMed

    Holmes, S W; Kertay, L; Adamson, L B; Holland, C L; Clance, P R

    1993-02-01

    Many of the discrepancies reported to date in empirical investigations of the impostor phenomenon (IP) may be due in part to (a) the use of different methods for identifying individuals suffering from this syndrome (impostors), (b) the common use of a median split procedure to classify subjects and (c) the fact that subjects in many studies were drawn from impostor-prone samples. In this study, we compared the scores of independently identified impostors and nonimpostors on two instruments designed to measure the IP: Harvey's I-P Scale and Clance's IP Scale. The results suggest that Clance's scale may be the more sensitive and reliable instrument. Cutoff score suggestions for both instruments are offered.

  10. Noise Reduction Technologies for Turbofan Engines

    NASA Technical Reports Server (NTRS)

    Huff, Dennis L.

    2007-01-01

    Significant progress continues to be made with noise reduction for turbofan engines. NASA has conducted and sponsored research aimed at reducing noise from commercial aircraft. Since it takes many years for technologies to be developed and implemented, it is important to have aggressive technology goals that lead the target entry into service dates. Engine noise is one of the major contributors to the overall sound levels as aircraft operate near airports. Turbofan engines are commonly used on commercial transports due to their advantage for higher performance and lower noise. The noise reduction comes from combinations of changes to the engine cycle parameters and low noise design features. In this paper, an overview of major accomplishments from recent NASA research programs for engine noise will be given.

  11. Left ventricular ejection fraction may not be useful as an end point of thrombolytic therapy comparative trials.

    PubMed

    Califf, R M; Harrelson-Woodlief, L; Topol, E J

    1990-11-01

    In the era of comparative and adjunctive trials in reperfusion therapy, the need to develop alternative end points for mortality reduction is clear. Left ventricular ejection fraction, which has been commonly used as a surrogate, is problematic due to missing values, technically inadequate studies, and lack of correlation with mortality results in controlled reperfusion trials performed to date. In this paper, we present a composite clinical end point that includes, in order, severity of adverse outcome death, hemorrhagic stroke, nonhemorrhagic stroke, poor ejection fraction (less than 30%), reinfarction, heart failure, and pulmonary edema. Such a composite index may be useful to detect true therapeutic benefit in reperfusion trials without necessitating greater than 20-30,000 patient enrollment.

  12. Viral hepatitis vaccination during pregnancy.

    PubMed

    Zhao, Yueyuan; Jin, Hui; Zhang, Xuefeng; Wang, Bei; Liu, Pei

    2016-04-02

    Viral hepatitis is a serious global public health problem. It is also a common cause of jaundice and gestational complications in pregnant women. Moreover, infected mothers can transmit the virus to their fetus or neonate, which may increase disease burden and decrease quality of life. To date, commercial vaccines have been developed for hepatitis A, B, and E and are available to the general population. The Advisory Committee on Immunization Practices currently accepts emergency vaccination against hepatitis A and B during pregnancy due to benefits that overweight the potential risks. While there are limited data from trials with limited numbers of samples that suggest the efficacy or safety of hepatitis B and E vaccines in pregnant women, additional data are necessary to provide evidence of vaccination during pregnancy.

  13. Active microbial biofilms in deep poor porous continental subsurface rocks.

    PubMed

    Escudero, Cristina; Vera, Mario; Oggerin, Monike; Amils, Ricardo

    2018-01-24

    Deep continental subsurface is defined as oligotrophic environments where microorganisms present a very low metabolic rate. To date, due to the energetic cost of production and maintenance of biofilms, their existence has not been considered in poor porous subsurface rocks. We applied fluorescence in situ hybridization techniques and confocal laser scanning microscopy in samples from a continental deep drilling project to analyze the prokaryotic diversity and distribution and the possible existence of biofilms. Our results show the existence of natural microbial biofilms at all checked depths of the Iberian Pyrite Belt (IPB) subsurface and the co-occurrence of bacteria and archaea in this environment. This observation suggests that multi-species biofilms may be a common and widespread lifestyle in subsurface environments.

  14. First in vivo traumatic brain injury imaging via magnetic particle imaging

    NASA Astrophysics Data System (ADS)

    Orendorff, Ryan; Peck, Austin J.; Zheng, Bo; Shirazi, Shawn N.; Ferguson, R. Matthew; Khandhar, Amit P.; Kemp, Scott J.; Goodwill, Patrick; Krishnan, Kannan M.; Brooks, George A.; Kaufer, Daniela; Conolly, Steven

    2017-05-01

    Emergency room visits due to traumatic brain injury (TBI) is common, but classifying the severity of the injury remains an open challenge. Some subjective methods such as the Glasgow Coma Scale attempt to classify traumatic brain injuries, as well as some imaging based modalities such as computed tomography and magnetic resonance imaging. However, to date it is still difficult to detect and monitor mild to moderate injuries. In this report, we demonstrate that the magnetic particle imaging (MPI) modality can be applied to imaging TBI events with excellent contrast. MPI can monitor injected iron nanoparticles over long time scales without signal loss, allowing researchers and clinicians to monitor the change in blood pools as the wound heals.

  15. An Integer Batch Scheduling Model for a Single Machine with Simultaneous Learning and Deterioration Effects to Minimize Total Actual Flow Time

    NASA Astrophysics Data System (ADS)

    Yusriski, R.; Sukoyo; Samadhi, T. M. A. A.; Halim, A. H.

    2016-02-01

    In the manufacturing industry, several identical parts can be processed in batches, and setup time is needed between two consecutive batches. Since the processing times of batches are not always fixed during a scheduling period due to learning and deterioration effects, this research deals with batch scheduling problems with simultaneous learning and deterioration effects. The objective is to minimize total actual flow time, defined as a time interval between the arrival of all parts at the shop and their common due date. The decision variables are the number of batches, integer batch sizes, and the sequence of the resulting batches. This research proposes a heuristic algorithm based on the Lagrange Relaxation. The effectiveness of the proposed algorithm is determined by comparing the resulting solutions of the algorithm to the respective optimal solution obtained from the enumeration method. Numerical experience results show that the average of difference among the solutions is 0.05%.

  16. Molecular dynamics simulation of potentiometric sensor response: the effect of biomolecules, surface morphology and surface charge.

    PubMed

    Lowe, B M; Skylaris, C-K; Green, N G; Shibuta, Y; Sakata, T

    2018-05-10

    The silica-water interface is critical to many modern technologies in chemical engineering and biosensing. One technology used commonly in biosensors, the potentiometric sensor, operates by measuring the changes in electric potential due to changes in the interfacial electric field. Predictive modelling of this response caused by surface binding of biomolecules remains highly challenging. In this work, through the most extensive molecular dynamics simulation of the silica-water interfacial potential and electric field to date, we report a novel prediction and explanation of the effects of nano-morphology on sensor response. Amorphous silica demonstrated a larger potentiometric response than an equivalent crystalline silica model due to increased sodium adsorption, in agreement with experiments showing improved sensor response with nano-texturing. We provide proof-of-concept that molecular dynamics can be used as a complementary tool for potentiometric biosensor response prediction. Effects that are conventionally neglected, such as surface morphology, water polarisation, biomolecule dynamics and finite-size effects, are explicitly modelled.

  17. Identical twins with mature cystic teratomas treated with laparoscopic surgery: Two case reports.

    PubMed

    Mabuchi, Yasushi; Ota, Nami; Kobayashi, Aya; Tanizaki, Yuko; Minami, Sawako; Ino, Kazuhiko

    2017-02-01

    Mature cystic teratomas are the most common among all ovarian neoplasms, representing 30-40% of the cases. However, to the best of our knowledge, there have been only two reports of mature cystic teratomas occurring in identical twins to date. We herein report a case of identical twins with mature cystic teratomas who were treated with laparoscopic surgery. A 32-year-old woman was referred to our hospital due to a tumor in the right ovary. The patient underwent laparoscopic resection of the ovarian tumor and the pathological diagnosis was benign mature cystic teratoma. Two years later, the identical twin of the abovementioned patient was referred to our hospital also due to a right ovarian tumor. The patient underwent laparoscopic resection of the ovarian tumor and the pathological diagnosis was benign mature cystic teratoma. Therefore, for early diagnosis, it may be important to consider the possibility of mature cystic teratoma in the identical twin of a patient, even in the absence of symptoms.

  18. Genetic Causes of Recurrent Pregnancy Loss.

    PubMed

    Page, Jessica M; Silver, Robert M

    2016-09-01

    Pregnancy loss is one of the most common obstetric complications, affecting over 30% of conceptions. A considerable proportion of losses are due to genetic abnormalities. Indeed, over 50% of early pregnancy losses have been associated with chromosomal abnormalities. Most are due to de novo nondisjunctional events but balanced parental translocations are responsible for a small but important percentage of genetic abnormalities in couples with recurrent pregnancy loss. In the past, assessment of genetic abnormalities was limited to karyotype performed on placental or fetal tissue. However, advances in molecular genetic technology now provide rich genetic information about additional genetic causes of and risk factors for pregnancy loss. In addition, the use of preimplantation genetic testing in couples undergoing in vitro fertilization has the potential to decrease the risk of pregnancy loss from genetic abnormalities. To date, efficacy is uncertain but considerable potential remains. This chapter will review what is known about genetic causes of recurrent pregnancy loss with a focus on novel causes and potential treatments. Remaining knowledge gaps will be highlighted.

  19. A Framework for Classifying and Resolving Semantic Conflicts Using the Enhanced Entity-Relationship Model

    DTIC Science & Technology

    1992-09-01

    rank, social security number, and date of birth, sex , race, etc. It also keeps data on marital status, number of dependents, and whether a member’s...specification as listed in the appendix. OPINS stores similar common personnel information to that in the ADMI database, such as name, rank, sex , etc.. The...34+ NAME (comp) "+ DATE..OF-.BIRTH (comp) "+ SEX "+ BACE-MIHNIC "+ ETHNIC..GROUP "+ PAYýENTRY-.BASE..DATE (comp) "+ SERVICE "+ MOS (comp) "+ DATE-OF

  20. Continuous monitoring of seasonal phenological development by BBCH code

    NASA Astrophysics Data System (ADS)

    Cornelius, Christine; Estrella, Nicole; Menzel, Annette

    2010-05-01

    Phenology, the science of recurrent seasonal natural events, is a proxy for changes in ecosystems due to recent global climate change. Phenological studies mostly deal with data considering the beginning of different development stages e.g. budburst or the beginning of flowering. Just few studies focus on the end of phenological stages, such as the end of flowering or seed dispersal. Information about the entire development cycle of plants, including data of the end of stages, are received by observing plants according to the extended BBCH-scale (MEIER 1997). The scale is a standardized growth stage key which allows a less labor intensive, weekly observation rhythm. Every week frequencies of all occurring phenological stages are noted. These frequencies then constitute the basis to interpolate the development of each phenological stage, even though it was not being seen during field work. Due to the lack of studies using this kind of key for observations over the entire development cycle there is no common methodology to analyze the data. So our objective was to find a method of analysis, with which onset dates as well as endpoints of each development stage could be defined. Three different methods of analysis were compared. Results show that there is no significant difference in onset dates of phenological stages between all methods tested. However, the method of pooled pre/post stage development seems to be most suitable for climate change studies, followed by the method of cumulative stage development and the method of weighted plant development.

  1. U-series dating of impure carbonates: An isochron technique using total-sample dissolution

    USGS Publications Warehouse

    Bischoff, J.L.; Fitzpatrick, J.A.

    1991-01-01

    U-series dating is a well-established technique for age determination of Late Quaternary carbonates. Materials of sufficient purity for nominal dating, however, are not as common as materials with mechanically inseparable aluminosilicate detritus. Detritus contaminates the sample with extraneous Th. We propose that correction for contamination is best accomplished with the isochron technique using total sample dissolution (TSD). Experiments were conducted on artificial mixtures of natural detritus and carbonate and on an impure carbonate of known age. Results show that significant and unpredictable transfer of radionuclides occur from the detritus to the leachate in commonly used selective leaching procedures. The effects of correcting via leachate-residue pairs and isochron plots were assessed. Isochrons using TSD gave best results, followed by isochron plots of leachates only. ?? 1991.

  2. 76 FR 34903 - Revisions to Framework Adjustment 45 to the Northeast Multispecies Fishery Management Plan and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ... Management Plan and Sector Annual Catch Entitlements; Updated Annual Catch Limits for Sectors and the Common... (ACLs) for common pool vessels (common pool sub-ACLs), ACLs for sector vessels (sector sub-ACLs), and... number of participants electing to fish in either sectors or the common pool fishery in FY 2011. DATES...

  3. 75 FR 29459 - Fisheries of the Northeastern United States; Northeast Multispecies Fishery; Revisions to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-26

    ... Catch Entitlements: Updated Annual Catch Limits for Sectors and the Common Pool for Fishing Year 2010... fishing year (FY) 2010 specification of annual catch limits (ACLs) for common pool vessels (common pool... fish in the common pool for FY 2010. DATES: Effective May 21, 2010 through April 30, 2011. FOR FURTHER...

  4. Taking Stock of Behavioral Measures of Adolescent Dating Violence

    PubMed Central

    SMITH, JACLYN; MULFORD, CARRIE; LATZMAN, NATASHA E.; THARP, ANDRA TETEN; NIOLON, PHYLLIS HOLDITCH; BLACHMAN-DEMNER, DARA

    2018-01-01

    The past 2 decades have witnessed an increase in dating violence awareness and research. As the field evolves, it is critical to examine the definition and measurement of adolescent dating violence. This article summarizes the behavioral measures of adolescent dating violence used in the field. Based on a review of the literature and federally funded studies, we identified 48 different measures. The most commonly used measures were the Conflict Tactics Scale–2, the Safe Dates Scale, and the Conflict in Adolescent Dating Relationship Inventory, which all examine aspects of psychological, physical, and sexual violence. Researchers also adapted or created their own measures. This article concludes with a discussion of developments for consideration as the field moves forward. PMID:29606849

  5. 78 FR 20901 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-08

    ... Marketing Inc. submits Category Seller Clarification to be effective 3/29/2013. Filed Date: 3/29/13... submits Cost- Based Tariffs Compliance Filing to be effective 4/1/2013. Filed Date: 3/29/13. Accession... to be effective N/A. Filed Date: 3/29/13. Accession Number: 20130329-5223. Comments Due: 5 p.m. ET 4...

  6. Effects of incubation temperatures on embryonic and larval survival in rainbow trout, Oncorhynchus mykiss

    USDA-ARS?s Scientific Manuscript database

    Incubation temperature is commonly used by hatcheries to manipulate hatch date in salmonids including rainbow trout (Oncorhynchus mykiss). Target dates for hatching often change during the incubation period and require a sudden adjustment in temperature. Although there are many studies charac...

  7. 77 FR 66361 - Reserve Requirements of Depository Institutions: Reserves Simplification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-05

    ... simplifications related to the administration of reserve requirements: 1. Create a common two-week maintenance... earlier than it would implement the common maintenance period and the penalty-free band. The Board... effective July 12, 2012. The Board announced January 24, 2013, as the implementation date for the common two...

  8. QTLs for heading date and plant height under multiple environments in rice.

    PubMed

    Han, Zhongmin; Hu, Wei; Tan, Cong; Xing, Yongzhong

    2017-02-01

    Both heading date and plant height are important traits related to grain yield in rice. In this study, a recombinant inbred lines (RILs) population was used to map quantitative trait loci (QTLs) for both traits under 3 long-day (LD) environments and 1 short-day (SD) environment. A total of eight QTLs for heading date and three QTLs for plant height were detected by composite interval mapping under LD conditions. Additional one QTL for heading date and three QTLs for plant height were identified by Two-QTL model under LD conditions. Among them, major QTLs qHd7.1, qHd7.2 and qHd8 for heading date, and qPh1 and qPh7.1 for plant height were commonly detected. qHd7.1 and qHd7.2 were mapped to small regions of less than 1 cM. Genome position comparison of previously cloned genes with QTLs detected in this study revealed that qHd5 and qPh3.1 were two novel QTLs. The alleles of these QTLs increasing trait values were dispersed in both parents, which well explained the transgressive segregation observed in this population. In addition, the interaction between qHd7.1 and qHd8 was detected under all LD conditions. Multiple-QTL model analysis revealed that all QTLs and their interactions explained over 80% of heading date variation and 50% of plant height variation. Two heading date QTLs were detected under SD condition. Of them, qHd10 were commonly identified under LD condition. The difference in QTL detection between LD and SD conditions indicated most heading date QTLs are sensitive to photoperiod. These findings will benefit breeding design for heading date and plant height in rice.

  9. Use of infrared camera to understand bats' access to date palm sap: implications for preventing Nipah virus transmission.

    PubMed

    Khan, M Salah Uddin; Hossain, Jahangir; Gurley, Emily S; Nahar, Nazmun; Sultana, Rebeca; Luby, Stephen P

    2010-12-01

    Pteropus bats are commonly infected with Nipah virus, but show no signs of illness. Human Nipah outbreaks in Bangladesh coincide with the date palm sap harvesting season. In epidemiologic studies, drinking raw date palm sap is a risk factor for human Nipah infection. We conducted a study to evaluate bats' access to date palm sap. We mounted infrared cameras that silently captured images upon detection of motion on date palm trees from 5:00 pm to 6:00 am. Additionally, we placed two locally used preventative techniques, bamboo skirts and lime (CaCO₃) smeared on date palm trees to assess their effectiveness in preventing bats access to sap. Out of 20 camera-nights of observations, 14 identified 132 visits of bats around the tree, 91 to the shaved surface of the tree where the sap flow originates, 4 at the stream of sap moving toward the collection pot, and no bats at the tap or on the collection pots; the remaining 6 camera-nights recorded no visits. Of the preventative techniques, the bamboo skirt placed for four camera-nights prevented bats access to sap. This study confirmed that bats commonly visited date palm trees and physically contacted the sap collected for human consumption. This is further evidence that date palm sap is an important link between Nipah virus in bats and Nipah virus in humans. Efforts that prevent bat access to the shaved surface and the sap stream of the tree could reduce Nipah spillovers to the human population.

  10. Bayesian integration of radioisotope dating (210Pb, 137Cs, 241Am, 14C) and an 18-20th century mining history of Brotherswater, English Lake District

    NASA Astrophysics Data System (ADS)

    Schillereff, Daniel; Chiverrell, Richard; Macdonald, Neil; Hooke, Janet; Welsh, Katharine; Piliposyan, Gayane; Appleby, Peter

    2014-05-01

    Lake sediment records are often a useful tool for investigating landscape evolution as geomorphic changes in the catchment are reflected by altered sediment properties in the material transported through the watershed and deposited at the lake bed. Recent research at Brotherswater, an upland waterbody in the Lake District, northwest England, has focused on reconstructing historical floods from their sedimentary signatures and calculating long-term sediment and carbon budgets from fourteen sediment cores extracted from across the basin. Developing accurate chronological control is essential for these tasks. One sediment core (BW11-2; 3.5 m length) from the central basin has been dated using artificial radionuclide measurements (210Pb, 137Cs, 241Am) for the uppermost sediments and radiocarbon (14C) for lower sediments. The core appears to span the past 1500 years, however a number of problems have arisen. We present our explanations for these errors, the independent chronological techniques used to generate an accurate age-depth model for this core and methods for its transferral to the other 13 cores extracted from the basin. Two distinct 137Cs markers, corresponding to the 1986 Chernobyl disaster and 1960s weapons testing, confirm the 210Pb profile for sediment deposition since ~1950, but calculations prior to this appear erroneous, possibly due to a hiatus in the sediment record. We used high-resolution geochemical profiles (measured by XRF) to cross-correlate with a second 210Pb-dated chronology from a more distal location, which returned more sensible results. Unfortunately, the longer 14C sequence exhibits two age-reversals (radiocarbon dates that are too old). We believe the uppermost two dates are erroneous, due to a shift in inflow location as a flood prevention method ~1900 A.D., dated using information from historical maps. The lower age-reversal coincides with greater supply of terrigenous material to the lake (increased Zr, K, Ti concentrations), pointing to a hillslope clearance event. A widespread concurrent hillslope gullying phase in northwest England triggering enhanced soil erosion is thus the most likely explanation, as the presence of old carbon is a known issue for lakes in the region at this time. Applying a Bayesian age-depth modelling protocol is able to account for these age-reversals with some success. However, the greatest uncertainty in the model occurs across the 1700 -1900 A.D. time window as the radiocarbon percentages offer multiple age solutions due to fluctuating atmospheric 14C concentrations from fossil fuel emissions. We address this issue by incorporating into the model geochemical markers in the sediment core related to local point-source Pb mining of known-age; the most-likely age-depth curve is subsequently much more definitively resolved. Usefully, these mining-derived chronological markers bridge the temporal gap between artificial radionuclide and conventional radiocarbon dating which is a common problem in palaeolimnology. These distinctive geochemical mining profiles (Pb, Zn, Cu) have been mapped across all cores, enabling precise core correlation and confident transferral of the age-depth model, and reveal highly spatially variable sediment accumulation rates. This has enabled more accurate sediment and carbon budgets to be calculated and some insight into palaeoflood frequency to be obtained from the Brotherswater sediment sequence.

  11. Quantifying Damage at Multiple Loading Rates to Kevlar KM2 Fibers Due to Weaving and Finishing

    DTIC Science & Technology

    2013-06-01

    ARL-TR-6465 June 2013 Approved for public release; distribution is unlimited. NOTICES...ARL-TR-6465 June 2013 Quantifying Damage at Multiple Loading Rates to Kevlar KM2 Fibers Due to Weaving and Finishing Brett D. Sanborn...OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) June 2013 2. REPORT TYPE Final 3. DATES

  12. Divergence times in Caenorhabditis and Drosophila inferred from direct estimates of the neutral mutation rate.

    PubMed

    Cutter, Asher D

    2008-04-01

    Accurate inference of the dates of common ancestry among species forms a central problem in understanding the evolutionary history of organisms. Molecular estimates of divergence time rely on the molecular evolutionary prediction that neutral mutations and substitutions occur at the same constant rate in genomes of related species. This underlies the notion of a molecular clock. Most implementations of this idea depend on paleontological calibration to infer dates of common ancestry, but taxa with poor fossil records must rely on external, potentially inappropriate, calibration with distantly related species. The classic biological models Caenorhabditis and Drosophila are examples of such problem taxa. Here, I illustrate internal calibration in these groups with direct estimates of the mutation rate from contemporary populations that are corrected for interfering effects of selection on the assumption of neutrality of substitutions. Divergence times are inferred among 6 species each of Caenorhabditis and Drosophila, based on thousands of orthologous groups of genes. I propose that the 2 closest known species of Caenorhabditis shared a common ancestor <24 MYA (Caenorhabditis briggsae and Caenorhabditis sp. 5) and that Caenorhabditis elegans diverged from its closest known relatives <30 MYA, assuming that these species pass through at least 6 generations per year; these estimates are much more recent than reported previously with molecular clock calibrations from non-nematode phyla. Dates inferred for the common ancestor of Drosophila melanogaster and Drosophila simulans are roughly concordant with previous studies. These revised dates have important implications for rates of genome evolution and the origin of self-fertilization in Caenorhabditis.

  13. Solving the Martian meteorite age conundrum using micro-baddeleyite and launch-generated zircon.

    PubMed

    Moser, D E; Chamberlain, K R; Tait, K T; Schmitt, A K; Darling, J R; Barker, I R; Hyde, B C

    2013-07-25

    Invaluable records of planetary dynamics and evolution can be recovered from the geochemical systematics of single meteorites. However, the interpreted ages of the ejected igneous crust of Mars differ by up to four billion years, a conundrum due in part to the difficulty of using geochemistry alone to distinguish between the ages of formation and the ages of the impact events that launched debris towards Earth. Here we solve the conundrum by combining in situ electron-beam nanostructural analyses and U-Pb (uranium-lead) isotopic measurements of the resistant micromineral baddeleyite (ZrO2) and host igneous minerals in the highly shock-metamorphosed shergottite Northwest Africa 5298 (ref. 8), which is a basaltic Martian meteorite. We establish that the micro-baddeleyite grains pre-date the launch event because they are shocked, cogenetic with host igneous minerals, and preserve primary igneous growth zoning. The grains least affected by shock disturbance, and which are rich in radiogenic Pb, date the basalt crystallization near the Martian surface to 187 ± 33 million years before present. Primitive, non-radiogenic Pb isotope compositions of the host minerals, common to most shergottites, do not help us to date the meteorite, instead indicating a magma source region that was fractionated more than four billion years ago to form a persistent reservoir so far unique to Mars. Local impact melting during ejection from Mars less than 22 ± 2 million years ago caused the growth of unshocked, launch-generated zircon and the partial disturbance of baddeleyite dates. We can thus confirm the presence of ancient, non-convecting mantle beneath young volcanic Mars, place an upper bound on the interplanetary travel time of the ejected Martian crust, and validate a new approach to the geochronology of the inner Solar System.

  14. 76 FR 4201 - Common Crop Insurance Regulations, Macadamia Nut Crop Insurance Provisions; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... Insurance Regulations, Macadamia Nut Crop Insurance Provisions; Correction AGENCY: Federal Crop Insurance... pertinent, related to the insurance of macadamia nuts. DATES: Effective Date: January 25, 2011. FOR FURTHER... Nut Crop Insurance Provisions to specify the correct crop year to which it was applicable. It was...

  15. Psychological Abuse Perpetration in College Dating Relationships: Contributions of Gender, Stress, and Adult Attachment Orientations

    ERIC Educational Resources Information Center

    Gormley, Barbara; Lopez, Frederick G.

    2010-01-01

    This study investigated whether gender, stressful problems common among college students, and adult attachment orientations (anxiety and avoidance) contributed to self-reported perpetration of psychological abuse in dating relationships among 127 college students. College men's stress levels were the strongest predictor of perpetration of…

  16. 76 FR 22058 - Reducing Regulatory Burden; Retrospective Review Under Executive Order 13563

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-20

    ... program data that is common across agencies to be collected once and utilized or redistributed to agency... operating costs by sharing similar data across participating agencies. DATES: Comments and information are... simplify and standardize, to the extent practical, acreage reporting processes, program dates, and data...

  17. In situ LA-ICPMS U–Pb dating of cassiterite without a known-age matrix-matched reference material: Examples from worldwide tin deposits spanning the Proterozoic to the Tertiary

    USGS Publications Warehouse

    Neymark, Leonid; Holm-Denoma, Christopher S.; Moscati, Richard J.

    2018-01-01

    Cassiterite (SnO2), a main ore mineral in tin deposits, is suitable for U–Pb isotopic dating because of its relatively high U/Pb ratios and typically low common Pb. We report a LA-ICPMS analytical procedure for U–Pb dating of this mineral with no need for an independently dated matrix-matched cassiterite standard. LA-ICPMS U-Th-Pb data were acquired while using NIST 612 glass as a primary non-matrix-matched standard. Raw data are reduced using a combination of Iolite™ and other off-line data reduction methods. Cassiterite is extremely difficult to digest, so traditional approaches in LA-ICPMS U-Pb geochronology that utilize well-characterized matrix-matched reference materials (e.g., age values determined by ID-TIMS) cannot be easily implemented. We propose a new approach for in situ LA-ICPMS dating of cassiterite, which benefits from the unique chemistry of cassiterite with extremely low Th concentrations (Th/U ratio of 10−4 or lower) in some cassiterite samples. Accordingly, it is assumed that 208Pb measured in cassiterite is mostly of non-radiogenic origin—it was initially incorporated in cassiterite during mineral formation, and can be used as a proxy for common Pb. Using 208Pb as a common Pb proxy instead of 204Pb is preferred as 204Pb is much less abundant and is also compromised by 204Hg interference during the LA-ICPMS analyses.Our procedure relies on 208Pb/206Pb vs 207Pb/206Pb (Pb-Pb) and Tera-Wasserburg 207Pb/206Pb vs 238U/206Pb (U-Pb) isochron dates that are calculated for a ~1.54 Ga low-Th cassiterite reference material with varying amounts of common Pb that we assume remained a closed U-Pb system. The difference between the NIST 612 glass normalized biased U-Pb date and the Pb-Pb age of the reference material is used to calculate a correction factor (F) for instrumental U-Pb fractionation. The correction factor (F) is then applied to measured U/Pb ratios and Tera-Wasserburg isochron dates are obtained for the unknown cassiterite analyzed in the same analytical session. This allows for U-Pb dating of cassiterite of any age with no need for an independently dated matrix-matched reference material, nor assumptions about the isotopic composition of common Pb.Results for cassiterite from tin deposits in Bolivia, Brazil, China, Russia, Saudi Arabia, South Africa, Spain, and the United Kingdom, with ages ranging from ~20 Ma to ~2060 Ma, demonstrate the applicability of this approach across a broad range of geologic time. These ages are in good agreement with published geochronology of the host rocks associated with the tin deposits and with previously published U-Pb ages of some cassiterites from the same deposits. Thus, our in situ LA-ICPMS methodology verifies the use of cassiterite as a reliable U-Pb mineral-geochronometer with the advantages of fast and relatively low cost in situ analyses with moderate spatial resolution.

  18. Identification of Reference Genes for Quantitative Real-Time PCR in Date Palm (Phoenix dactylifera L.) Subjected to Drought and Salinity.

    PubMed

    V Patankar, Himanshu; M Assaha, Dekoum V; Al-Yahyai, Rashid; Sunkar, Ramanjulu; Yaish, Mahmoud W

    2016-01-01

    Date palm is an important crop plant in the arid and semi-arid regions supporting human population in the Middle East and North Africa. These areas have been largely affected by drought and salinity due to insufficient rainfall and improper irrigation practices. Date palm is a relatively salt- and drought-tolerant plant and more recently efforts have been directed to identifying genes and pathways that confer stress tolerance in this species. Quantitative real-time PCR (qPCR) is a promising technique for the analysis of stress-induced differential gene expression, which involves the use of stable reference genes for normalizing gene expression. In an attempt to find the best reference genes for date palm's drought and salinity research, we evaluated the stability of 12 most commonly used reference genes using the geNorm, NormFinder, BestKeeper statistical algorithms and the comparative ΔCT method. The comprehensive results revealed that HEAT SHOCK PROTEIN (HSP), UBIQUITIN (UBQ) and YTH domain-containing family protein (YT521) were stable in drought-stressed leaves whereas GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (GAPDH), ACTIN and TUBULIN were stable in drought-stressed roots. On the other hand, SMALL SUBUNIT RIBOSOMAL RNA (25S), YT521 and 18S ribosomal RNA (18S); and UBQ, ACTIN and ELONGATION FACTOR 1-ALPHA (eEF1a) were stable in leaves and roots, respectively, under salt stress. The stability of these reference genes was verified by using the abiotic stress-responsive CYTOSOLIC Cu/Zn SUPEROXIDE DISMUTASE (Cyt-Cu/Zn SOD), an ABA RECEPTOR, and a PROLINE TRANSPORTER 2 (PRO) genes. A combination of top 2 or 3 stable reference genes were found to be suitable for normalization of the target gene expression and will facilitate gene expression analysis studies aimed at identifying functional genes associated with drought and salinity tolerance in date palm.

  19. Snooping and Sexting: Digital Media as a Context for Dating Aggression and Abuse Among College Students.

    PubMed

    Reed, Lauren A; Tolman, Richard M; Ward, L Monique

    2016-11-01

    Digital dating abuse (DDA) is a pattern of behaviors that control, pressure, or threaten a dating partner using a cell phone or the Internet. A survey of 365 college students was conducted, finding that digital monitoring behaviors were especially common. There were no gender differences in number of DDA behaviors experienced, but women reported more negative hypothetical reactions to sexual messaging than men. DDA was associated with measures of physical, sexual, and psychological dating violence. Results suggest that digital media are a context for potentially harmful dating behaviors, and the experience of DDA may differ by gender for sexual behaviors. © The Author(s) 2016.

  20. 76 FR 20422 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... Extraordinary Market Volatility, To Extend the Effective Date of the Pilot Until the Earlier of August 11, 2011 or the Date on Which a Limit Up/Limit Down Mechanism To Address Extraordinary Market Volatility, if... due to extraordinary market volatility, to extend the effective date of the pilot by which such rule...

  1. 76 FR 20418 - Self-Regulatory Organizations; NYSE Amex LLC; Notice of Filing and Immediate Effectiveness of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... Volatility, To Extend the Effective Date of the Pilot Until the Earlier of August 11, 2011 or the Date on Which a Limit Up/Limit Down Mechanism To Address Extraordinary Market Volatility, If Adopted, Applies... due to extraordinary market volatility, to extend the effective date of the pilot by which such rule...

  2. 77 FR 22337 - Privacy Act of 1974; Amendment to an Existing System of Records, Inventory Management System Also...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ... or before this period which would result in a contrary determination. Comments Due Date: May 14, 2012... of whether or not the family is or has participated in the Family Self-sufficiency (FSS) program..., middle initial, date of birth, age on effective date of action, sex, relationship to head of household...

  3. 78 FR 16261 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-14

    ... succession to be effective 1/ 1/2013. Filed Date: 3/4/13. Accession Number: 20130304-5097. Comments Due: 5 p..., Inc. submits supplement to January 30, 2013 Application for Market Based Authority. Filed Date: 2/20...

  4. 76 FR 72210 - Notice of Proposed Information Collection: Comment Request Congressional Earmark Grants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-22

    ...-Special Project (EDI-SP) and Neighborhood Initiative (NI) grants. DATES: Comments Due Date: January 23... Neighborhood Initiative (NI) grantees. The agency has used the application, semi-annual reports and close-out...

  5. 78 FR 76759 - Fisheries of the Northeastern United States; Northeast Multispecies Fishery; Trimester Closure...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ... Fishery; Trimester Closure for the Common Pool Fishery AGENCY: National Marine Fisheries Service (NMFS... Trimester 3, from January 1, 2014, through April 30, 2014, to common pool vessels, because the Trimester 3... intended to prevent the overharvest of the common pool's allocation of GOM haddock. DATES: The closure of...

  6. 77 FR 14697 - Fisheries of the Northeastern United States; Northeast Multispecies Fishery; Trip Limit...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-13

    ... Fishery; Trip Limit Adjustments for the Common Pool Fishery AGENCY: National Marine Fisheries Service...) multispecies common pool vessels for the remainder of the 2011 fishing year (FY), through April 30, 2012. This... catch of these stocks to approach their pertinent common pool sub-annual catch limits (sub-ACLs). DATES...

  7. A solitary polypoid gastric metastasis 20 years after renal cell carcinoma: an event to be considered, and a brief review of the literature.

    PubMed

    Onorati, M; Petracco, G; Uboldi, P; Redaelli, D G; Romagnoli, S; Albertoni, M; Di Nuovo, F

    2013-08-01

    The incidence of gastric metastasis is 2.6%. Although all primary neoplasms can metastasize to the stomach, most originate from melanoma or breast and lung cancer. Their most common endoscopic appearance is a "volcano-like" polypoid mass covered by normal mucosa that may show a central ulceration. Renal cell carcinoma, clear cell type, is known to spread hematogenously, and isolated metastasis to the stomach is a rare event. In this report, we describe a gastric recurrence of RCC, clear-cell type, in a 80-year-old patient who had undergone nephrectomy 20 years before. We also performed a brief review of the literature to update the number of cases described to date. Metastatic involvement of the stomach should be suspected in any patient with a previous history of renal cell carcinoma, clear cell type, presenting with gastrointestinal symptoms, even if many years after nephrectomy. The peculiarity of our case is due to the very late presentation of the gastric metastasis. Only two cases of very late gastric metastases from RCC, clear cell type, have been described in the literature, to date.

  8. Is there a Lyme-like disease in Australia? Summary of the findings to date.

    PubMed

    Chalada, Melissa Judith; Stenos, John; Bradbury, Richard Stewart

    2016-12-01

    Lyme Borreliosis is a common tick-borne disease of the northern hemisphere caused by the spirochaetes of the Borrelia burgdorferi sensu lato ( B. burgdorferi s. l.) complex. It results in multi-organ disease with arthritic, cardiac, neurological and dermatological manifestations. In the last twenty-five years there have been over 500 reports of an Australian Lyme-like syndrome in the scientific literature. However, the diagnoses of Lyme Borreliosis made in these cases have been primarily by clinical presentation and laboratory results of tentative reliability and the true cause of these illnesses remains unknown. A number of animals have been introduced to Australia that may act as B. burgdorferi s. l. reservoirs in Lyme-endemic countries, and there are some Australian Ixodes spp. and Haemaphysalis spp. ticks whose geographical distribution matches that of the Australian Lyme-like cases. Four published studies have searched for Borrelia in Australian ticks, with contradicting results. The cause of the potential Lyme-like disease in Australia remains to be defined. The evidence to date as to whether these illnesses are caused by a Borrelia species, another tick borne pathogen or are due to a novel or unrelated aetiology is summarised in this review.

  9. Characterization and microbial analysis of first recorded observation of Conicera similis Haliday (Diptera: Phoridae) in forensic decomposition study in Romania.

    PubMed

    Iancu, Lavinia; Junkins, Emily N; Purcarea, Cristina

    2018-05-03

    The identification of necrophagous insect diversity and dynamics has forensic significance for postmortem interval estimation specific to burial. Few studies regarding the necrophagous entomofauna from buried remains have been performed to date. In contrast to the exposed carcasses, the accessibility of soil to insects is limited due to burial depth and is dependent on soil type. This study highlights the colonization behavior of Conicera similis (Haliday 1833) (Diptera: Phoridae) during carcass decomposition, a previously unobserved taxon in Romania. Adult and larvae specimens were collected from rat (Rattus norvegicus) carcasses buried at 40 cm depth in an urban park environment in June 2016 during active decomposition and their presence and activity period was correlated with the environmental parameters variation. Bacterial diversity from C. similis female adult and larvae specimens was determined via 16S rRNA gene Illumina sequencing to further characterize these commonly encountered and forensically important necrophagous insects. This report signals the easternmost geographical location in Europe (Bucharest, Romania) of C. similis to date. Copyright © 2018 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

  10. Improving 14C dating precision in dynamic, brackish waters by one order of magnitude: 87Sr/86Sr isotopes as a quantitative proxy for 14C reservoir age.

    NASA Astrophysics Data System (ADS)

    Lougheed, B.; Davies, G.; Filipsson, H. L.; van der Lubbe, J.; Snowball, I.

    2016-12-01

    Accurate geochronologies are crucial for reconstructing the sensitivity of brackish and estuarine environments to external impacts. A common geochronological method used for such studies is radiocarbon (14C) dating, but its application in brackish environments is severely limited by an inability to quantify spatiotemporal variations in 14C reservoir age, or R(t), due to dynamic interplay between river runoff and marine water in these environments. Additionally, old carbon effects and species-specific behavioural processes also influence 14C ages. Using the world's largest brackish water body (the estuarine Baltic Sea) as a test-bed, combined with a comprehensive approach that objectively excludes both old carbon and species-specific effects, we demonstrate that it is possible to use 87Sr/86Sr ratios to quantify R(t) in ubiquitous mollusc shell material, leading to an almost one order of magnitude increase in Baltic Sea 14C geochronological precision over the current state-of-the-art. We propose that this novel proxy method can be developed for other brackish water bodies worldwide, thereby improving geochronological control in these climate sensitive, near-coastal environments.

  11. Tafenoquine and its potential in the treatment and relapse prevention of Plasmodium vivax malaria: the evidence to date.

    PubMed

    Ebstie, Yehenew A; Abay, Solomon M; Tadesse, Wondmagegn T; Ejigu, Dawit A

    2016-01-01

    Despite declining global malaria incidence, the disease continues to be a threat to people living in endemic regions. In 2015, an estimated 214 million new malaria cases and 438,000 deaths due to malaria were recorded. Plasmodium vivax is the second most common cause of malaria next to Plasmodium falciparum. Vivax malaria is prevalent especially in Southeast Asia and the Horn of Africa, with enormous challenges in controlling the disease. Some of the challenges faced by vivax malaria-endemic countries include limited access to effective drugs treating liver stages of the parasite (schizonts and hypnozoites), emergence/spread of drug resistance, and misperception of vivax malaria as nonlethal. Primaquine, the only 8-aminoquinoline derivative approved by the US Food and Drug Administration, is intended to clear intrahepatic hypnozoites of P. vivax (radical cure). However, poor adherence to a prolonged treatment course, drug-induced hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency, and the emergence of resistance make it imperative to look for alternative drugs. Therefore, this review focuses on data accrued to date on tafenoquine and gives insight on the potential role of the drug in preventing relapse and radical cure of patients with vivax malaria.

  12. Capturing pair-wise epistatic effects associated with three agronomic traits in barley.

    PubMed

    Xu, Yi; Wu, Yajun; Wu, Jixiang

    2018-04-01

    Genetic association mapping has been widely applied to determine genetic markers favorably associated with a trait of interest and provide information for marker-assisted selection. Many association mapping studies commonly focus on main effects due to intolerable computing intensity. This study aims to select several sets of DNA markers with potential epistasis to maximize genetic variations of some key agronomic traits in barley. By doing so, we integrated a MDR (multifactor dimensionality reduction) method with a forward variable selection approach. This integrated approach was used to determine single nucleotide polymorphism pairs with epistasis effects associated with three agronomic traits: heading date, plant height, and grain yield in barley from the barley Coordinated Agricultural Project. Our results showed that four, seven, and five SNP pairs accounted for 51.06, 45.66 and 40.42% for heading date, plant height, and grain yield, respectively with epistasis being considered, while corresponding contributions to these three traits were 45.32, 31.39, 31.31%, respectively without epistasis being included. The results suggested that epistasis model was more effective than non-epistasis model in this study and can be more preferred for other applications.

  13. ADST, Version Description Document for the BDS-D M1 1.0.0

    DTIC Science & Technology

    1992-12-22

    1.1 date: 1992/10/01 23:32:59; author: crn-adst; state: Exp; Initial Version RCS file: ./common/include/cig- f /RCS/if...eh~eff.h,v Working file: if...libsrc/libfifo/RCS/ f -enqueue.c,v working file: f_enqueue.c head: 1.1 description: ITO - 6.6.1 baseline revision 1.1 date: 1992/10/01 23:43:13; author...crn-adst; state: Exp; Initial Version RCS file: ./common/libsrc/libfifo/RCS/ f -init.c,v working file: f -init.c head: 1.1 description: ITO - 6.6.1

  14. Challenges for geochronologies in permafrost environments: the case of Bol'shoy Lyakhovsky, Siberian Arctic

    NASA Astrophysics Data System (ADS)

    Wetterich, Sebastian; Fuchs, Margret; Schwamborn, Georg; Schirrmeister, Lutz

    2015-04-01

    Ice-bearing Quaternary deposits in permafrost environments comprise valuable archives of paleoenvironmental and palaeo-landscape dynamics over several glacial-interglacial cycles. Information on past conditions manifest in the mineralogical, organic and ice inventories. The characteristic ground ice abundance of permafrost evolves largely due to water supply by precipitation and surface run-off, while air, and consequently near-surface, temperatures control to which depth deposits freeze or thaw. This has several consequences on the continuity of permafrost sequences. Permafrost preservation or degradation depends basically on (1) climatic conditions during formation, (2) their decoupling from the active layer depth and (3) past relief conditions. In this context, warmer interstadial and interglacial periods promote permafrost degradation by ground ice melt and subsequent surface subsidence. Such processes are commonly named as thermokarst that forms basins and valleys within older deposits and creates new accumulation areas. Shifts between periglacial accumulation and erosion frequently cause gaps in permafrost sequences. This complicates geochronological interpretations as representatives of consecutive Quaternary periods may be found at laterally different positions and altitudes. Additionally, they may comprise differing sediment properties as a consequence of paleo-relief and related process dynamic. With this contribution, we discuss the challenges for establishing Quaternary geochronologies of arctic permafrost sequences using the example of Bol'shoy Lyakhovsky Island (New Siberian Archipelago). The island exposes sequences at its southern coast that are among the oldest dated Quaternary terrestrial permafrost deposits. Various proxies for paleo environmental reconstruction unravel at least three generations of cold- and warm-stage deposition ranging from the Holocene to the Eemian (MIS 5e) Interglacial, and potentially beyond that. However, the stratigraphic context is ambiguous due to the vertical discontinuity and potential hiatuses, especially for units older than the MIS 3 Interstadial. For example, stadial conditions of the MIS 4 and the MIS 6(?) are recorded in sediment units locally named as Kuchchugui Suite. The floodplain sediments are dated by AMS radiocarbon to < 53 ka BP and to 57 - 79 ka by IRSL. The lithostratigraphic context of other sites suggests Kuchchugui-like floodplain deposits that pre-date the Eemian Interglacial but remain without numerical ages so far. Despite the use of different dating methods to obtain permafrost formation ages there are still obvious discrepancies when comparing geochronological results from different physical methods. One main problem is that dating methods are generally not well established on frozen material and refer to differing permafrost components. Some of the challenges are related to unknown influences of freeze-thaw processes on chemical and physical parameters relevant for the chosen dating technique. Here, we cannot give the ultimate answer, but rather aim to highlight and discuss the advantages and drawbacks of the different dating techniques applied in our study area, including AMS radiocarbon, luminescence and radioisotope Th/U methods.

  15. Gun muzzle flash detection using a CMOS single photon avalanche diode

    NASA Astrophysics Data System (ADS)

    Merhav, Tomer; Savuskan, Vitali; Nemirovsky, Yael

    2013-10-01

    Si based sensors, in particular CMOS Image sensors, have revolutionized low cost imaging systems but to date have hardly been considered as possible candidates for gun muzzle flash detection, due to performance limitations, and low SNR in the visible spectrum. In this study, a CMOS Single Photon Avalanche Diode (SPAD) module is used to record and sample muzzle flash events in the visible spectrum, from representative weapons, common on the modern battlefield. SPADs possess two crucial properties for muzzle flash imaging - Namely, very high photon detection sensitivity, coupled with a unique ability to convert the optical signal to a digital signal at the source pixel, thus practically eliminating readout noise. This enables high sampling frequencies in the kilohertz range without SNR degradation, in contrast to regular CMOS image sensors. To date, the SPAD has not been utilized for flash detection in an uncontrolled environment, such as gun muzzle flash detection. Gun propellant manufacturers use alkali salts to suppress secondary flashes ignited during the muzzle flash event. Common alkali salts are compounds based on Potassium or Sodium, with spectral emission lines around 769nm and 589nm, respectively. A narrow band filter around the Potassium emission doublet is used in this study to favor the muzzle flash signal over solar radiation. This research will demonstrate the SPAD's ability to accurately sample and reconstruct the temporal behavior of the muzzle flash in the visible wavelength under the specified imaging conditions. The reconstructed signal is clearly distinguishable from background clutter, through exploitation of flash temporal characteristics.

  16. Molecular characterisation of four double-flowered mutants of Silene dioica representing four centuries of variation

    PubMed Central

    Ingle, Elizabeth K. S.; Gilmartin, Philip M.

    2015-01-01

    Records of double-flowered Silene dioica date from the late sixteenth century and four named varieties are grown today, as previously, for their horticultural interest. Although double-flowered mutants have been characterized in several plants, their study in dioecious species is of particular interest due to influences of the homeotic mutation on the different floral whorl configurations in males and females. We have analysed four double-flowered varieties of Silene dioica: Flore Pleno and Rosea Plena date back to the seventeenth and nineteenth centuries, Thelma Kay and Firefly were recognized in the latter part of the twentieth and early twenty-first centuries. We have analysed the floral structure of the four varieties, which have distinct floral architectures. Based on Y chromosome-specific PCR analysis we show that Firefly is male and that the other three varieties are female: Random Amplification of Polymorphic DNA (RAPD) analyses suggested a common origin for the three female varieties. The double-flowered phenotype in all four varieties is caused by mutation of the C-function MADS-box transcription factor gene SDM1. We show that Firefly carries a unique 44bp insertion into SDM1, revealing an independent origin for this variety. Comparative analysis of SDM1 cDNA and genomic sequences in Flore Pleno, Rosea Plena and Thelma Kay shows that all three are caused by the same 7bp insertion within SDM1 and therefore share a common origin. The three alleles also differ by several single nucleotide polymorphisms, which represent somatic mutations accumulated over four centuries of asexual propagation. PMID:25878355

  17. Soccer-related Facial Trauma: Multicenter Experience in 2 Brazilian University Hospitals

    PubMed Central

    Dini, Gal M.; Pereira, Max D.; Gurgel, Augusto; Bastos, Endrigo O.; Nagarkar, Purushottam; Gemperli, Rolf; Ferreira, Lydia M.

    2014-01-01

    Background: Soccer is the most popular sport in Brazil and a high incidence of related trauma is reported. Maxillofacial trauma can be quite common, sometimes requiring prolonged hospitalization and invasive procedures. To characterize soccer-related facial fractures needing surgery in 2 major Brazilian Centers. Methods: A retrospective review of trauma medical records from the Plastic Surgery Divisions at the Universidade Federal de São Paulo–Escola Paulista de Medicina and the Hospital das Clinicas–Universidade de São Paulo was carried out to identify patients who underwent invasive surgical procedures due to acute soccer-related facial fractures. Data points reviewed included gender, date of injury, type of fracture, date of surgery, and procedure performed. Results: A total of 45 patients (31 from Escola Paulista de Medicina and 14 from Universidade de São Paulo) underwent surgical procedures to address facial fractures between March 2000 and September 2013. Forty-four patients were men, and mean age was 28 years. The fracture patterns seen were nasal bones (16 patients, 35%), orbitozygomatic (16 patients, 35%), mandibular (7 patients, 16%), orbital (6 patients, 13%), frontal (1 patient, 2%), and naso-orbito-ethmoid (1 patient, 2%). Mechanisms of injury included collisions with another player (n = 39) and being struck by the ball (n = 6). Conclusions: Although it is less common than orthopedic injuries, soccer players do sustain maxillofacial trauma. Knowledge of its frequency is important to first responders, nurses, and physicians who have initial contact with patients. Missed diagnosis or delayed treatment can lead to facial deformities and functional problems in the physiological actions of breathing, vision, and chewing. PMID:25289361

  18. In situ SIMS U-Pb dating of hydrothermal rutile: reliable age for the Zhesang Carlin-type gold deposit in the golden triangle region, SW China

    NASA Astrophysics Data System (ADS)

    Pi, Qiaohui; Hu, Ruizhong; Xiong, Bin; Li, Qiuli; Zhong, Richen

    2017-12-01

    The contiguous region between Guangxi, Guizhou, and Yunnan, commonly referred to as the Golden Triangle region in SW China, hosts many Carlin-type gold deposits. Previously, the ages of the gold mineralization in this region have not been well constrained due to the lack of suitable minerals for radiometric dating. This paper reports the first SIMS U-Pb age of hydrothermal rutile crystals for the Zhesang Carlin-type gold deposit in the region. The hydrothermal U-bearing rutile associated with gold-bearing sulfides in the deposit yields an U-Pb age of 213.6 ± 5.4 Ma, which is within the range of the previously reported arsenopyrite Re-Os isochron ages (204 ± 19 to 235 ± 33 Ma) for three other Carlin-type gold deposits in the region. Our new and more precise rutile U-Pb age confirms that the gold mineralization was contemporaneous with the Triassic W-Sn mineralization and associated granitic magmatism in the surrounding regions. Based on the temporal correlation, we postulate that coeval granitic plutons may be present at greater depths in the Golden Triangle region and that the formation of the Carlin-type gold deposits is probably linked to the coeval granitic magmatism in the region. This study clearly demonstrates that in situ rutile U-Pb dating is a robust tool for the geochronogical study of hydrothermal deposits that contain hydrothermal rutile.

  19. Charting novel allergens from date palm pollen (Phoenix sylvestris) using homology driven proteomics.

    PubMed

    Saha, Bodhisattwa; Bhattacharya, Swati Gupta

    2017-08-08

    Pollen grains from Phoenix sylvestris (date palm), a commonly cultivated tree in India has been found to cause severe allergic diseases in an increasing percentage of hypersensitive individuals. To unearth its allergenic components, pollen protein were profiled by two-dimensional gel electrophoresis followed by immunoblotting with date palm pollen sensitive patient sera. Allergens were identified by MALDI-TOF/TOF employing a layered proteomic approach combining conventional database dependent search and manual de novo sequencing followed by homology-based search as Phoenix sylvestris is unsequenced. Derivatization of tryptic peptides by acetylation has been demonstrated to differentiate the 'b' from the 'y' ions facilitating efficient de novo sequencing. Ten allergenic proteins were identified, out of which six showed homology with known allergens while others were reported for the first time. Amongst these, isoflavone reductase, beta-conglycinin, S-adenosyl methionine synthase, 1, 4 glucan synthase and beta-galactosidase were commonly reported as allergens from coconut pollen and presumably responsible for cross-reactivity. One of the allergens had IgE binding epitope recognized by its glycan moiety. The allergenic potency of date palm pollen has been demonstrated using in vitro tests. The identified allergens can be used to develop vaccines for immunotherapy against date palm pollen allergy. Identification of allergenic proteins from sources harboring them is essential in developing therapeutic interventions. This is the first comprehensive study on the identification of allergens from Phoenix sylvestris (date palm) pollen, one of the major aeroallergens in India using a proteomic approach. Proteomic methods are being increasingly used to identify allergens. However, since many of these proteins arise from species which are un-sequenced, it becomes difficult to interpret those using conventional proteomics. Date palm being an unsequenced species, the IgE-reactive proteins have been identified using a stratified proteomic workflow incorporating manual de novo sequencing and homology-based proteomics. This study also gives an insight into the presence of glycan nature of the IgE binding epitopes. Five proteins have been found to be common with coconut pollen allergens and presumably responsible for cross-reactivity. These can be used in diagnostics to differentiate patient cohorts allergic to both coconut and date palm pollen from true date palm pollen allergic subjects. This would also determine better specific immunotherapy regimes between the two cohorts. The allergens identified herein have potential towards vaccine development in date palm pollen allergy as well as in enriching the existing catalogue of allergenic proteins. Copyright © 2017. Published by Elsevier B.V.

  20. 77 FR 27220 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-09

    ... Succession to be effective 7/1/ 2012. Filed Date: 5/1/12. Accession Number: 20120501-5319. Comments Due: 5 p... LLC Market Based Rate Tariff to be effective 6/4/2012. Filed Date: 5/1/12. Accession Number: 20120501...

  1. 77 FR 10763 - Notice of Submission of Proposed Information Collection to OMB; Manufactured Housing Dispute...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-23

    ... party or agency, and to act as neutrals, mediators, and arbitrators. DATES: Comments Due Date: March 26... possibly contact the submitting party or agency, and to act as neutrals, mediators, and arbitrators...

  2. 77 FR 1478 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-10

    ... PSA to be effective 12/17/2010. Filed Date: 12/2/11. Accession Number: 20111202-5194. Comments Due: 5.... Description: 20111202 TexLa Restated PSA to be effective 12/17/ 2010. Filed Date: 12/2/11. Accession Number...

  3. 77 FR 27381 - Financial Crimes Enforcement Network: Customer Due Diligence Requirements for Financial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ...-AB15 Financial Crimes Enforcement Network: Customer Due Diligence Requirements for Financial... concerning customer due diligence requirements for financial institutions. DATES: Written comments on the... customer due diligence requirements for financial institutions.\\1\\ FinCEN received several comments on the...

  4. 75 FR 8044 - Summer Undergraduate Research Program Extension of Due Date for Proposals

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ...: Due to extreme weather conditions in the Mid-Atlantic United States, NIST is extending the deadline.... Eastern Time, Tuesday, February 16, 2010. Due to extreme weather conditions and associated power outages...

  5. Breaking up is hard to do: how teens end violent dating relationships.

    PubMed

    Martsolf, Donna S; Draucker, Claire Burke; Brandau, Melvina

    2013-01-01

    Dating violence affects nearly 30% of teens and is associated with numerous negative health outcomes. Teens do not tend to use adult or peer assistance to end violent dating relationships, and little is known about how they manage to end them. The purpose of this study was to determine the common ways in which teens end violent dating relationships. Grounded theory methods were used to analyze transcribed interviews conducted with a community sample of 83 young adults who had experienced dating violence as teens. Participants described six ways of ending violent dating relationships: deciding enough is enough; becoming interested in someone else; being on again, off again; fading away; deciding it's best for us both; and moving away. Professionals working with teens can present the six ways of breaking up as a tool to initiate discussion about the issues involved in ending violent dating relationships.

  6. Clinical profile of a Mediterranean population sensitised to date palm pollen (Phoenix dactylifera). A retrospective study.

    PubMed

    Huertas, A J; López-Sáez, M P; Carnés, J

    2011-01-01

    Date palm pollen allergy is frequently associated with polysensitisation. Observational studies have suggested that date-palm-sensitised individuals could be included in a distinct group of polysensitised patients. The objectives of the study were to analyse the clinical characteristics of a group of patients diagnosed of date-palm pollen allergy and to compare them with pollen allergic patients without date-palm sensitisation. Forty-eight palm-pollen sensitised individuals were classified as Group A. A control group of 48 patients sensitised to pollens but without palm-pollen allergy were included as Group B. All individuals were skin prick tested with a common battery of aeroallergens. Information about age, sex, family history of atopy, respiratory symptoms, food allergy and sensitisation to other pollens were considered variables of the study. Specific IgE and the allergogram to date-palm pollen were determined in a subgroup of Group A. Significant differences in the family history of atopy and number of sensitisations were observed. Both parameters were significantly higher in Group A. Group A showed high prevalence of asthma and higher level of sensitisation to foods (p < 0.05). Significant differences were obtained for sensitisation to epithelia and pollens. Pho d 2 was the most commonly recognised allergen (83.3%) in the palm-pollen allergic group. Date-palm pollen allergic patients constitute a homogeneous group characterised for showing bronchial asthma, sensitisation to food allergens and polysensitisation. These results suggest that the reasons for sensitisation to date-palm pollen remain to be elucidated, but could relate to the existence of as yet non-identified pan-allergens. Copyright © 2010 SEICAP. Published by Elsevier Espana. All rights reserved.

  7. 76 FR 41676 - Retail Foreign Exchange Transactions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ... with persons who are not ``eligible contract participants'' (commonly referred to as ``retail forex... temporary Rule 15b12-1T to allow a registered broker-dealer to engage in a retail forex business until July... forex transactions. DATES: Effective Date: Rule 15b12-1T is effective on July 15, 2011 and will remain...

  8. Expanding the network of crossdated tree-ring chronologies for Sequoia sempervirens

    Treesearch

    Allyson L. Carroll; Stephen C. Sillett; Ethan J. Coonen; Benjamin G. Iberle

    2017-01-01

    Crossdated tree-ring chronologies for the Arcata Community Forest (ACF) and Muir Woods National Monument (Muir Woods) expand the spatial coverage of dated coast redwood (Sequoia sempervirens (D. Don) Endl.) series. Crossdating relies on the common pattern of ring-width variation among tree populations, and dated chronologies have many applications...

  9. Induction motor control

    NASA Technical Reports Server (NTRS)

    Hansen, Irving G.

    1990-01-01

    Electromechanical actuators developed to date have commonly utilized permanent magnet (PM) synchronous motors. More recently switched reluctance (SR) motors have been advocated due to their robust characteristics. Implications of work which utilizes induction motors and advanced control techniques are discussed. When induction motors are operated from an energy source capable of controlling voltages and frequencies independently, drive characteristics are obtained which are superior to either PM or SR motors. By synthesizing the machine frequency from a high frequency carrier (nominally 20 kHz), high efficiencies, low distortion, and rapid torque response are available. At this time multiple horsepower machine drives were demonstrated, and work is on-going to develop a 20 hp average, 40 hp peak class of aerospace actuators. This effort is based upon high frequency power distribution and management techniques developed by NASA for Space Station Freedom.

  10. Induction motor control

    NASA Technical Reports Server (NTRS)

    Hansen, Irving G.

    1990-01-01

    Electromechanical actuators developed to date have commonly ultilized permanent magnet (PM) synchronous motors. More recently switched reluctance (SR) motors have been advocated due to their robust characteristics. Implications of work which utilized induction motors and advanced control techniques are discussed. When induction motors are operated from an energy source capable of controlling voltages and frequencies independently, drive characteristics are obtained which are superior to either PM or SR motors. By synthesizing the machine frequency from a high-frequency carrier (nominally 20 kHz), high efficiencies, low distortion, and rapid torque response are available. At this time multiple horsepower machine drives were demonstrated, and work is on-going to develop a 20 hp average, 40 hp peak class of aerospace actuators. This effort is based upon high-frequency power distribution and management techniques developed by NASA for Space Station Freedom.

  11. Volcanology and mineral deposits

    USGS Publications Warehouse

    Lipman, P.W.

    1990-01-01

    In contrast, old volcanic regions, which host many of the world's major hydrothermal-vein, porphyry, and massive-sulfide ore deposits, have been studied mainly by economic geologists, regional stratigraphers, and structural geologists who have limited familiarity with the complexities of volcanic processes. Such "dead" volcanoes, ranging in age from a few million million years (tertiary) to a few billion years (Precambrian), are commonly incompletely and discontinuously preserved due to rapid erosion of originally high-standing volcanic edifices. They can be difficult to date reliably, especially in terms of the time scales of individual volcanic events, and are variably hydrothermally altered-impeding high-resolution petrologic and geochemical studies. Many volcanologists, geochemists, and geophysicists who work on active volcanoes accordingly have been reluctant to become involved in studies of such less tractable rocks. 

  12. Viral hepatitis vaccination during pregnancy

    PubMed Central

    Zhao, Yueyuan; Jin, Hui; Zhang, Xuefeng; Wang, Bei; Liu, Pei

    2016-01-01

    Abstract Viral hepatitis is a serious global public health problem. It is also a common cause of jaundice and gestational complications in pregnant women. Moreover, infected mothers can transmit the virus to their fetus or neonate, which may increase disease burden and decrease quality of life. To date, commercial vaccines have been developed for hepatitis A, B, and E and are available to the general population. The Advisory Committee on Immunization Practices currently accepts emergency vaccination against hepatitis A and B during pregnancy due to benefits that overweight the potential risks. While there are limited data from trials with limited numbers of samples that suggest the efficacy or safety of hepatitis B and E vaccines in pregnant women, additional data are necessary to provide evidence of vaccination during pregnancy. PMID:26833263

  13. Gender Role Attitudes and Male Adolescent Dating Violence Perpetration: Normative Beliefs as Moderators.

    PubMed

    Reyes, H Luz McNaughton; Foshee, Vangie A; Niolon, Phyllis Holditch; Reidy, Dennis E; Hall, Jeffrey E

    2016-02-01

    Commonly used dating violence prevention programs assume that promotion of more egalitarian gender role attitudes will prevent dating violence perpetration. Empirical research examining this assumption, however, is limited and inconsistent. The current study examined the longitudinal association between gender role attitudes and physical dating violence perpetration among adolescent boys (n = 577; 14 % Black, 5 % other race/ethnicity) and examined whether injunctive (i.e., acceptance of dating violence) and descriptive (i.e., beliefs about dating violence prevalence) normative beliefs moderated the association. As expected, the findings suggest that traditional gender role attitudes at T1 were associated with increased risk for dating violence perpetration 18 months later (T2) among boys who reported high, but not low, acceptance of dating violence (injunctive normative beliefs) at T1. Descriptive norms did not moderate the effect of gender role attitudes on dating violence perpetration. The results suggest that injunctive norms and gender role attitudes work synergistically to increase risk for dating violence perpetration among boys; as such, simultaneously targeting both of these constructs may be an effective prevention approach.

  14. A Longitudinal Investigation of Heavy Drinking and Physical Dating Violence in Men and Women

    PubMed Central

    Stappenbeck, Cynthia A.; Fromme, Kim

    2010-01-01

    Examinations of heavy drinking and dating violence have typically focused on either female victimization or male perpetration; yet recent findings indicate that mutual aggression is the most common pattern of dating violence. The current study investigated the relation between heavy drinking and dating violence for both men and women. Participants (N = 2,247) completed surveys that assessed their heavy drinking and dating violence frequency across the first three years of college. Findings indicated that heavy drinking and dating violence were both relatively stable across time for men and women, but the relation between heavy drinking and dating violence differed by gender. For men, heavy drinking and dating violence were concurrently associated during their freshman year (Year 1), whereas for women heavy drinking during sophomore year (Year 2) predicted dating violence in their junior year (Year 3). In addition to providing educational material on healthy relationships and conflict resolution techniques, intervention efforts should target both heavy drinking and dating violence for men during or prior to their freshman year of college, whereas women may primarily benefit from efforts to reduce their heavy drinking. PMID:20079971

  15. Gender Role Attitudes and Male Adolescent Dating Violence Perpetration: Normative Beliefs as Moderators

    PubMed Central

    Reyes, H. Luz McNaughton; Foshee, Vangie A.; Niolon, Phyllis Holditch; Reidy, Dennis E.; Hall, Jeffrey E.

    2015-01-01

    Commonly used dating violence prevention programs assume that promotion of more egalitarian gender role attitudes will prevent dating violence perpetration. Empirical research examining this assumption, however, is limited and inconsistent. The current study examined the longitudinal association between gender role attitudes and physical dating violence perpetration among adolescent boys (n=577; 14% Black, 5% other race/ethnicity) and examined whether injunctive (i.e., acceptance of dating violence) and descriptive (i.e., beliefs about dating violence prevalence) normative beliefs moderated the association. As expected, the findings suggest that traditional gender role attitudes at T1 were associated with increased risk for dating violence perpetration 18 months later (T2) among boys who reported high, but not low, acceptance of dating violence (injunctive normative beliefs) at T1. Descriptive norms did not moderate the effect of gender role attitudes on dating violence perpetration. The results suggest that injunctive norms and gender role attitudes work synergistically to increase risk for dating violence perpetration among boys; as such, simultaneously targeting both of these constructs may be an effective prevention approach. PMID:25831994

  16. 76 FR 36564 - Notice of Submission of Proposed Information Collection to OMB; HOPE VI Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-22

    ... to manage the grants that are awarded. DATES: Comments Due Date: July 22, 2011. ADDRESSES: Interested... funds in accordance with the HOPE VI program authorizing statute, and to manage the grants that are...

  17. U-Pb Dating of Zircons and Phosphates in Lunar Meteorites, Acapulcoites and Angrites

    NASA Technical Reports Server (NTRS)

    Zhou, Q.; Zeigler, R. A.; Yin, Q. Z.; Korotev, R. L.; Joliff, B. L.; Amelin, Y.; Marti, K.; Wu, F. Y.; Li, X. H.; Li, Q. L.; hide

    2012-01-01

    Zircon U-Pb geochronology has made a great contribution to the timing of magmatism in the early Solar System [1-3]. Ca phosphates are another group of common accessory minerals in meteorites with great potential for U-Pb geochronology. Compared to zircons, the lower closure temperatures of the U-Pb system for apatite and merrillite (the most common phosphates in achondrites) makes them susceptible to resetting during thermal metamorphism. The different closure temperatures of the U-Pb system for zircon and apatite provide us an opportunity to discover the evolutionary history of meteoritic parent bodies, such as the crystallization ages of magmatism, as well as later impact events and thermal metamorphism. We have developed techniques using the Cameca IMS-1280 ion microprobe to date both zircon and phosphate grains in meteorites. Here we report U-Pb dating results for zircons and phosphates from lunar meteorites Dhofar 1442 and SaU 169. To test and verify the reliability of the newly developed phosphate dating technique, two additional meteorites, Acapulco, obtained from Acapulco consortium, and angrite NWA 4590 were also selected for this study as both have precisely known phosphate U-Pb ages by TIMS [4,5]. Both meteorites are from very fast cooled parent bodies with no sign of resetting [4,5], satisfying a necessity for precise dating.

  18. Common Rule Revisions: The Saga Continues

    EPA Science Inventory

    The Common Rule regulations that govern human subjects research were revised in 2017, after a 6-year rulemaking process. Changes were made in many areas, including informed consent, continuing review, exemptions and multi-site research, with an effective date of January 2018 (cur...

  19. 78 FR 34928 - Revisions to Framework Adjustment 50 to the Northeast Multispecies Fishery Management Plan and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-11

    ... Management Plan and Sector Annual Catch Entitlements; Updated Annual Catch Limits for Sectors and the Common... either sectors or the common pool fishery. DATES: Effective June 10, 2013, through April 30, 2014. FOR... to vessels not enrolled in a sector (referred to as the common pool). This allocation is also...

  20. Cyber dating abuse: prevalence, context, and relationship with offline dating aggression.

    PubMed

    Borrajo, E; Gámez-Guadix, M; Calvete, E

    2015-04-01

    The use of information and communication technologies (ICT) as tools to intimidate, harass, and control the partner has been, so far, little studied in the literature. The aim of this study was to determine the extension and sex differences of victimization of cyber dating abuse, as well as the context in which it occurs, and its relationship with offline psychological and physical aggressions. The sample consisted of 433 college students ages 18 to 30 years. The results showed that over 50% of the participants had been victims of some type of cyber dating abuse in the last six months. The most common behavior was the use of ICT to control the partner. Also, victims of cyber dating abuse were victimized repeatedly, an average of 23 times in the last six months. The data also showed that cyber dating abuse appear usually in a context of jealousy. Finally, the results revealed a significant relationship between cyber dating abuse and offline psychological dating aggressions. Limitations and future lines of research are discussed.

  1. An Up-to-date Approach to a Patient with a Suspected Autoinflammatory Disease

    PubMed Central

    Lidar, Merav; Giat, Eitan

    2017-01-01

    Autoinflammatory diseases (AID) are characterized by seemingly unprovoked self-limited attacks of fever and systemic inflammation potentially leading to amyloidosis. Familial Mediterranean fever (FMF) is the most common AID and therefore the most studied. Besides FMF, the other main hereditary AID are tumor necrosis factor-associated periodic fever syndrome (TRAPS), mevalonate kinase deficiency (MKD), and cryopyrin-associated periodic fever syndrome (CAPS). These hereditary diseases result from a mutant gene that is involved in the regulation of inflammation, resulting in a characteristic clinical phenotype. The differential diagnosis of AID can be challenging due to a wide overlap in clinical manifestations. Moreover, a considerable proportion of patients present with autoinflammatory symptoms but without a pathogenetic variant on genetic analysis. Furthermore, non-hereditary AID, such as the periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome, which is the most common AID in children worldwide, must be excluded in certain circumstances. Herein we shall review the main AID and describe a practical approach to diagnosis in a patient with a clinical suspicion of AID. PMID:28178435

  2. Experimental spinal cord trauma: a review of mechanically induced spinal cord injury in rat models.

    PubMed

    Abdullahi, Dauda; Annuar, Azlina Ahmad; Mohamad, Masro; Aziz, Izzuddin; Sanusi, Junedah

    2017-01-01

    It has been shown that animal spinal cord compression (using methods such as clips, balloons, spinal cord strapping, or calibrated forceps) mimics the persistent spinal canal occlusion that is common in human spinal cord injury (SCI). These methods can be used to investigate the effects of compression or to know the optimal timing of decompression (as duration of compression can affect the outcome of pathology) in acute SCI. Compression models involve prolonged cord compression and are distinct from contusion models, which apply only transient force to inflict an acute injury to the spinal cord. While the use of forceps to compress the spinal cord is a common choice due to it being inexpensive, it has not been critically assessed against the other methods to determine whether it is the best method to use. To date, there is no available review specifically focused on the current compression methods of inducing SCI in rats; thus, we performed a systematic and comprehensive publication search to identify studies on experimental spinalization in rat models, and this review discusses the advantages and limitations of each method.

  3. Development of a reliable extraction and quantification method for glucosinolates in Moringa oleifera.

    PubMed

    Förster, Nadja; Ulrichs, Christian; Schreiner, Monika; Müller, Carsten T; Mewis, Inga

    2015-01-01

    Glucosinolates are the characteristic secondary metabolites of plants in the order Brassicales. To date the common DIN extraction 'desulfo glucosinolates' method remains the common procedure for determination and quantification of glucosinolates. However, the desulfation step in the extraction of glucosinolates from Moringa oleifera leaves resulted in complete conversion and degradation of the naturally occurring glucosinolates in this plant. Therefore, a method for extraction of intact Moringa glucosinolates was developed and no conversion and degradation of the different rhamnopyranosyloxy-benzyl glucosinolates was found. Buffered eluents (0.1 M ammonium acetate) were necessary to stabilize 4-α-rhamnopyranosyloxy-benzyl glucosinolate (Rhamno-Benzyl-GS) and acetyl-4-α-rhamnopyranosyloxy-benzyl glucosinolate isomers (Ac-Isomers-GS) during HPLC analysis. Due to the instability of intact Moringa glucosinolates at room temperature and during the purification process of single glucosinolates, influences of different storage (room temperature, frozen, thawing and refreezing) and buffer conditions on glucosinolate conversion were analysed. Conversion and degradations processes were especially determined for the Ac-Isomers-GS III. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. Hepatitis A

    PubMed Central

    Maynard, James E.

    1976-01-01

    Hepatitis A is a disease of worldwide distribution which occurs in endemic and epidemic form and is transmitted primarily by person-to-person contact through the fecal-oral route. Common source epidemics due to contamination of food are relatively common, and water-borne epidemics have been described less frequently. The presumed etiologic agent of hepatitis A has now been visualized by immune electron microscopic (IEM) techniques in early acute-illness-phase stools of humans with hepatitis A as well as in chimpanzees experimentally infected with material known to contain hepatitis A virus. In addition, several new serologic tests for the detection of antibody against hepatitis A virus have been described. These include complement fixation and immune adherence techniques. Current data suggest that hepatitis A is caused by a single viral agent lacking the morphologic heterogeneity of hepatitis B viral components and that there may be relative antigenic homogeneity between strains of virus recovered from various parts of the world. Serologic studies to date also indicate that hepatitis A virus is not a major contributing cause in post-transfusion hepatitis. ImagesFIG. 2 PMID:183390

  5. Polysaccharides from marine macroalga, Padina gymnospora improve the nonspecific and specific immune responses of Cyprinus carpio and protect it from different pathogens.

    PubMed

    Rajendran, Priyatharsini; Subramani, Parasuraman Aiya; Michael, Dinakaran

    2016-11-01

    Immunostimulation by plant-derived compounds presents a fascinating alternative to vaccines and antibiotics in aquaculture. Fish farmers are longing for immunostimulants that activate both specific and nonspecific immune responses of fish and protect fishes from all possible infections. In this study, we observed that polysaccharide fraction from marine macroalga, Padina gymnospora stimulated the immune response of common carp Cyprinus carpio (Filed for patent, Indian patent no. 201641027311 dated:10-Aug-2016). Our results indicate that fish fed with polysaccharides as feed supplement improved all the immune parameters tested which include serum lysozyme, myeloperoxidase activities and antibody response. Further, polysaccharide fraction protected the fish from its common bacterial pathogens namely Aeromonas hydrophila and Edwardsiella tarda with relative percent survival (RPS) values of 80 and 60 respectively. Gene expression studies, indicate that the immunostimulation by P. gymnospora might be at least in part due to the upregulation of the cytokine interleukin-1β (IL-1β) and antimicrobial peptide lysozyme-C. Copyright © 2016 Elsevier Ltd. All rights reserved.

  6. Reducing Delay in Diagnosis: Multistage Recommendation Tracking.

    PubMed

    Wandtke, Ben; Gallagher, Sarah

    2017-11-01

    The purpose of this study was to determine whether a multistage tracking system could improve communication between health care providers, reducing the risk of delay in diagnosis related to inconsistent communication and tracking of radiology follow-up recommendations. Unconditional recommendations for imaging follow-up of all diagnostic imaging modalities excluding mammography (n = 589) were entered into a database and tracked through a multistage tracking system for 13 months. Tracking interventions were performed for patients for whom completion of recommended follow-up imaging could not be identified 1 month after the recommendation due date. Postintervention compliance with the follow-up recommendation required examination completion or clinical closure (i.e., biopsy, limited life expectancy or death, or subspecialist referral). Baseline radiology information system checks performed 1 month after the recommendation due date revealed timely completion of 43.1% of recommended imaging studies at our institution before intervention. Three separate tracking interventions were studied, showing effectiveness between 29.0% and 57.8%. The multistage tracking system increased the examination completion rate to 70.5% (a 52% increase) and reduced the rate of unknown follow-up compliance and the associated risk of delay in diagnosis to 13.9% (a 74% decrease). Examinations completed after tracking intervention generated revenue of 4.1 times greater than the labor cost. Performing sequential radiology recommendation tracking interventions can substantially reduce the rate of unknown follow-up compliance and add value to the health system. Unknown follow-up compliance is a risk factor for delay in diagnosis, a form of preventable medical error commonly identified in malpractice claims involving radiologists and office-based practitioners.

  7. Investigating the Usefulness of Cosmogenic in situ 14C for the Dating of Alluvial Fan Surfaces

    NASA Astrophysics Data System (ADS)

    Goehring, B. M.; Blisniuk, K.; Moon, S.

    2017-12-01

    Accurate and unambiguous constraints on the age of alluvial fan surfaces remain one of the ultimate achievements for the application of cosmogenic nuclides exposure dating. Information on the age of a fan is not only useful for understanding the rate of sediment transfer from adjacent hillslopes, but also the displacement of an alluvial fan surface and their incised channels represent one of the clearest markers of long-term (102 - 104 years) slip along faults in many regions. Common nuclides such as 10Be, 26Al, and 36Cl, which are often applied to dating alluvial fans, are hampered by inheritance due to their long half-life as nuclides accumulate during exhumation and transport. Here, we present results from a systematic study investigating the usefulness of the cosmogenic nuclide carbon-14 (14C) from the Ash Wash Fan of the Anza Borrego Desert, California, which is well-dated with both 10Be of amalgamated boulder surfaces and U-series ages from pedogenic carbonates. We sampled individual boulders from multiple fan channel bars, rather than an amalgamation of many boulders from a single fan channel bar. Our new14C results yield a median ± half-interquartile age of 4.7 ± 0.8 ka (n = 4, 1 outlier removed). These results are in excellent agreement with the existing U-series and new p-IR-IRSL chronology (5.2 ± 0.3 ka and 5.5 ± 0.8 ka, respectively), but slightly younger than the previously published 10Be amalgamation date of 7.0 ± 1.0 ka. In contrast, 10Be exposure dates of the same boulder in our study yield a median ± half-interquartile age of 10.9 ± 2.6 ka, which we interpret to be the result of insufficient burial time during transport and/or erosion of the boulder to remove accumulated 10Be. Our results suggest that 14C may be a viable chronometer of alluvial fan surfaces less than ca. 25 ka. Finally, inspired by approaches in the burial dating community, we will also explore the possibility of a paired nuclide isochron approach. Measured 14C and 10Be concentrations display a strong correlation (r2 = 0.9), suggesting there may be gains to be made using a paired nuclide approach; we will explore this relationship further in the presentation.

  8. 75 FR 7599 - Notice of Public Hearing; Passenger Vessel Financial Responsibility

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-22

    ... FEDERAL MARITIME COMMISSION Notice of Public Hearing; Passenger Vessel Financial Responsibility AGENCY: Federal Maritime Commission. ACTION: Public hearing; extension of time to file requests to appear... testimony concerning the Commission's Passenger Vessel Financial Responsibility Program. DATES: The due date...

  9. 24 CFR 578.103 - Recordkeeping requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... different Continuum of Care due to imminent threat of further domestic violence, dating violence, sexual... must retain: (i) Documentation of the original incidence of domestic violence, dating violence, sexual assault, or stalking, only if the original violence is not already documented in the program participant's...

  10. 24 CFR 578.103 - Recordkeeping requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... different Continuum of Care due to imminent threat of further domestic violence, dating violence, sexual... must retain: (i) Documentation of the original incidence of domestic violence, dating violence, sexual assault, or stalking, only if the original violence is not already documented in the program participant's...

  11. Frequency & specificity of RBC alloantibodies in patients due for surgery in Iran.

    PubMed

    Reyhaneh, Khademi; Ahmad, Gharehbaghian; Gharib, Karimi; Vida, Vafaiyan; Raheleh, Khademi; Mehdi, Tabrizi Namini

    2013-01-01

    Red blood cell alloimmunization is common in patients receiving multiple blood transfusions. Since the probability of repeat transfusion increases with longer life expectancy, it is important to study to which extent alloimmunized patients with a history of transfusion are prone to form alloantibodies after transfusion events. The aim of this study was to retrospectively analyze the alloimmunization against RBCs among transfused patients who were to undergo elective surgery in Tehran, Iran. A total of 3092 occasionally transfused patients, who were to undergo elective surgery, in four hospitals in Tehran were included in the study. For patients with alloantibodies, the data about sex, date of birth, history of transfusion, surgery, abortion and alloantibody specificity were collected. Clinically significant alloantibodies were found in 30 patients. The presence of positive antibodies in the patients for whom cross-match had been done was one per cent. Most of them had surgery history or transfusion record during the preceding year. The three most frequent alloantibodies were anti-K (23.53%), anti- E (20.59%) and anti-c (17.56%). The most common clinically significant alloantibodies identified in men and women were anti-K and anti-E, respectively. The most common causes of alloimmunization for men were surgery history and transfusion record and for women pregnancy.

  12. Due Date Assignment in a Dynamic Job Shop with the Orthogonal Kernel Least Squares Algorithm

    NASA Astrophysics Data System (ADS)

    Yang, D. H.; Hu, L.; Qian, Y.

    2017-06-01

    Meeting due dates is a key goal in the manufacturing industries. This paper proposes a method for due date assignment (DDA) by using the Orthogonal Kernel Least Squares Algorithm (OKLSA). A simulation model is built to imitate the production process of a highly dynamic job shop. Several factors describing job characteristics and system state are extracted as attributes to predict job flow-times. A number of experiments under conditions of varying dispatching rules and 90% shop utilization level have been carried out to evaluate the effectiveness of OKLSA applied for DDA. The prediction performance of OKLSA is compared with those of five conventional DDA models and back-propagation neural network (BPNN). The experimental results indicate that OKLSA is statistically superior to other DDA models in terms of mean absolute lateness and root mean squares lateness in most cases. The only exception occurs when the shortest processing time rule is used for dispatching jobs, the difference between OKLSA and BPNN is not statistically significant.

  13. LHD1, an allele of DTH8/Ghd8, controls late heading date in common wild rice (Oryza rufipogon).

    PubMed

    Dai, Xiaodong; Ding, Younian; Tan, Lubin; Fu, Yongcai; Liu, Fengxia; Zhu, Zuofeng; Sun, Xianyou; Sun, Xuewen; Gu, Ping; Cai, Hongwei; Sun, Chuanqing

    2012-10-01

    Flowering at suitable time is very important for plants to adapt to complicated environments and produce their seeds successfully for reproduction. In rice (Oryza rufipogon Griff.) photoperiod regulation is one of the important factors for controlling heading date. Common wild rice, the ancestor of cultivated rice, exhibits a late heading date and a more sensitive photoperiodic response than cultivated rice. Here, through map-based cloning, we identified a major quantitative trait loci (QTL) LHD1 (Late Heading Date 1), an allele of DTH8/Ghd8, which controls the late heading date of wild rice and encodes a putative HAP3/NF-YB/CBF-A subunit of the CCAAT-box-binding transcription factor. Sequence analysis revealed that several variants in the coding region of LHD1 were correlated with a late heading date, and a further complementary study successfully rescued the phenotype. These results suggest that a functional site for LHD1 could be among those variants present in the coding region. We also found that LHD1 could down-regulate the expression of several floral transition activators such as Ehd1, Hd3a and RFT1 under long-day conditions, but not under short-day conditions. This indicates that LHD1 may delay flowering by repressing the expression of Ehd1, Hd3a and RFT1 under long-day conditions. © 2012 Institute of Botany, Chinese Academy of Sciences.

  14. Performance by heifers grazing sod-seeded cool-season annuals seeded on different dates using two tillage intensities

    USDA-ARS?s Scientific Manuscript database

    A total of 120 Gelbvieh x Angus crossbred heifers (552'2.5 lb initial BW) grazed pastures of common bermudagrass [Cynodon dactylon (L.) Pers.] overseeded with wheat (Triticum aestivum L.) and annual ryegrass (Lolium multiflorum Lam.) for a 3-year study to compare the effect of seeding dates and till...

  15. 77 FR 73089 - Cambria Investment Management, L.P. and Cambria ETF Trust; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-07

    ... Investing Fund's Advisory Group will not control (individually or in the aggregate) a Fund within the... group of investment companies as the series to acquire Shares. DATES: Filing Dates: The application was... Fund will (a) be advised by Cambria or an entity controlling, controlled by, or under common control...

  16. 26 CFR 1.338-2 - Nomenclature and definitions; mechanics of the section 338 election.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... purchase of stock under section 338(a)(2), a reference to new target with respect to its own deemed... target is the common parent on the acquisition date. (17) Target; old target; new target. Target is the... before the close of target's acquisition date. New target refers to target for subsequent periods. (18...

  17. 26 CFR 1.338-2 - Nomenclature and definitions; mechanics of the section 338 election.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... purchase of stock under section 338(a)(2), a reference to new target with respect to its own deemed... target is the common parent on the acquisition date. (17) Target; old target; new target. Target is the... before the close of target's acquisition date. New target refers to target for subsequent periods. (18...

  18. The Impact of Intimate Partner Violence on Decisions to Leave Dating Relationships: A Test of the Investment Model

    ERIC Educational Resources Information Center

    Rhatigan, Deborah L.; Street, Amy E.

    2005-01-01

    This study explored the impact of violence exposure on investment-model constructs within a sample of college women involved in heterosexual dating relationships. Results generally supported the "common sense" hypothesis, suggesting that violence negatively impacts satisfaction for and commitment to one's relationship and is positively associated…

  19. Using a Domestic and Sexual Violence Prevention Advocate to Implement a Dating Violence Prevention Program with Athletes

    ERIC Educational Resources Information Center

    Jaime, M. C. D.; Stocking, M.; Freire, K.; Perkinson, L.; Ciaravino, S.; Miller, E.

    2016-01-01

    "Coaching Boys into Men" is an evidence-based dating violence prevention program for coaches to implement with male athletes. A common adaptation of this program is delivery by domestic violence and sexual violence prevention advocates instead of coaches. We explored how this implementer adaptation may influence athlete uptake of program…

  20. Screening men for prostate and colorectal cancer in the United States: does practice reflect the evidence?

    PubMed

    Sirovich, Brenda E; Schwartz, Lisa M; Woloshin, Steven

    2003-03-19

    The debate about the efficacy of prostate-specific antigen (PSA) screening for prostate cancer has received substantial attention in the medical literature and the media, but the extent to which men are actually screened is unknown. If practice were evidence-based, PSA screening would be less common among men than colorectal cancer screening, a preventive service of broad acceptance and proven efficacy. To compare the prevalences of PSA and colorectal cancer screening among US men. The 2001 Behavioral Risk Factor Surveillance System, an annual population-based telephone survey of US adults conducted by the Centers for Disease Control and Prevention, was used to gather data on a representative sample of men aged 40 years or older from all 50 states and the District of Columbia (n = 49 315). Proportions of men ever screened and up to date on screening for prostate cancer (with PSA testing) and colorectal cancer (with fecal occult blood testing, flexible sigmoidoscopy, or colonoscopy). Overall, men are more likely to report having ever been screened for prostate cancer than for colorectal cancer; 75% of those aged 50 years or older have had a PSA test vs 63% for any colorectal cancer test (risk ratio [RR], 1.20; 95% confidence interval [CI], 1.18-1.21). Up-to-date PSA screening is also more common than colorectal cancer screening for men of all ages. Among men aged 50 to 69 years (those for whom there is the greatest consensus in favor of screening), 54% reported an up-to-date PSA screen, while 45% reported up-to-date testing for colorectal cancer (RR, 1.19; 95% CI, 1.16-1.21). In state-level analyses of this age group, men were significantly more likely to be up to date on prostate cancer screening compared with colorectal cancer screening in 27 states, while up-to-date colorectal cancer screening was more common in only 1 state. Among men in the United States, prostate cancer screening is more common than colorectal cancer screening. Physicians should ensure that men who choose to be screened for cancer are aware of the known mortality benefit of colorectal cancer screening and the uncertain benefits of screening for prostate cancer.

  1. Cough: an unmet clinical need

    PubMed Central

    Dicpinigaitis, Peter V

    2011-01-01

    Cough is among the most common complaints for which patients worldwide seek medical attention. Thus, the evaluation and treatment of cough result in tremendous financial expenditure and consumption of health care resources. Yet, despite the clinical significance of cough, research efforts aimed at improving diagnostic capabilities and developing more effective therapeutic agents have been, to date, disappointing in their limited scope and outcomes. Acute cough due to the common cold represents the most common type of cough. Currently, available medications for the symptomatic management of acute cough are inadequate due to lack of proven efficacy and/or their association with undesirable or intolerable side effects at anti-tussive doses. Subacute cough, often representing a prolonged post-viral response, is typically refractory to standard anti-tussive therapy. Few clinical trials have evaluated therapeutic options for subacute cough. Diagnostic challenges facing the clinician in the management of chronic cough include the determination of whether symptoms of upper airway cough syndrome (formerly, postnasal drip syndrome) or gastro-oesophageal reflux disease are indeed the underlying cause of cough. Chronic, refractory unexplained (formerly, idiopathic) cough must be distinguished from cough that has not been fully evaluated and treated according to current guideline recommendations. Eagerly awaited are new safe and effective anti-tussive agents for use when cough suppression is desired, regardless of underlying aetiology of cough, as well as practical, validated ambulatory cough counters to aid clinical assessment and future research in the field of cough. LINKED ARTICLES This article is part of a themed issue on Respiratory Pharmacology. To view the other articles in this issue visit http://dx.doi.org/10.1111/bph.2011.163.issue-1 PMID:21198555

  2. UPb ages of zircon rims: A new analytical method using the air-abrasion technique

    USGS Publications Warehouse

    Aleinikoff, J.N.; Winegarden, D.L.; Walter, M.

    1990-01-01

    We present a new technique for directly dating, by conventional techniques, the rims of zircons. Several circumstances, such as a xenocrystic or inherited component in igneous zircon and metamorphic overgrowths on igneous cores, can result in grains with physically distinct age components. Pneumatic abrasion has been previously shown by Krogh to remove overgrowths and damaged areas of zircon, leaving more resistant and isotopically less disturbed parts available for analysis. A new abrader design, which is capable of very gently grinding only tips and interfacial edges of even needle-like grains, permits easy collection of abraded material for dating. Five examples demonstrate the utility of the "dust-collecting" technique, including two studies that compare conventional, ion microprobe and abrader data. Common Pb may be strongly concentrated in the outermost zones of many zircons and this Pb is not easily removed by leaching (even in weak HF). Thus, the benefit of removing only the outermost zones (and avoiding mixing of age components) is somewhat compromised by the much higher common Pb contents which result in less precise age determinations. A very brief abrasion to remove the high common Pb zones prior to collection of material for dating is selected. ?? 1990.

  3. The State of State Standards--and the Common Core--in 2010

    ERIC Educational Resources Information Center

    Carmichael, Sheila Byrd; Martino, Gabrielle; Porter-Magee, Kathleen; Wilson, W. Stephen

    2010-01-01

    This review of state English language arts (ELA) and mathematics standards is the latest in a series of Fordham evaluations dating back to 1997. It comes at a critical juncture, as states across the land consider adoption of the Common Core State Standards. These are the authors' major findings: (1) Based on their criteria, the Common Core…

  4. 77 FR 37816 - Revisions to Framework Adjustment 47 to the Northeast Multispecies Fishery Management Plan and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-25

    ... Management Plan and Sector Annual Catch Entitlements; Updated Annual Catch Limits for Sectors and the Common... either sectors or the common pool fishery. DATES: Effective June 22, 2012, through April 30, 2013. FOR... for GOM cod on May 1, 2012 (77 FR 25623), consistent with the Council's request. The common pool and...

  5. The Common Good and Citizenship Education in England: A Moral Enterprise?

    ERIC Educational Resources Information Center

    Peterson, Andrew

    2011-01-01

    The notion of the common good has been cited as a key constituent of citizenship education in England, within which the development of a concern for the common good represents a key disposition. The term has, however, received little critical attention to date within the discourse of the subject, either in terms of its theoretical basis or its…

  6. Spectrum of sodium hypochlorite toxicity in man—also a concern for nephrologists

    PubMed Central

    Peck, Brandon; Workeneh, Biruh; Kadikoy, Huseyin; Patel, Samir J.

    2011-01-01

    Sodium hypochlorite (NaOCl) is the active ingredient in household bleach and is a very common chemical. It has been used in medical and commercial situations dating back to the 18th century for its disinfectant properties, including topical use in medicine as an antiseptic. For this indication, NaOCl is a proven and safe chemical. However, exposure of NaOCl beyond topical use, whether it is intentional or accidental, is associated with significant risks due to its strong oxidizing properties. Potentially damaging scenarios include ingestion, inhalation, deposition into tissue or injection into the bloodstream. All of these scenarios can lead to significant morbidity and even mortality. In this review, we examine the toxicity associated with NaOCl exposure and analyze potential mechanisms of injury, placing special emphasis on the potential for renal toxicity. Due to the extreme ease of access to household bleach products and its use in medicine, it is important for the clinician to understand the potential damage that can occur in NaOCl exposures so that complications can be prevented before they arise. PMID:25949487

  7. Descriptive epidemiology of veterinary events in flat racing Thoroughbreds in Great Britain (2000 to 2013).

    PubMed

    Rosanowski, S M; Chang, Y M; Stirk, A J; Verheyen, K L P

    2017-05-01

    To date, no large scale studies have reported race-day events requiring veterinary attention in British Thoroughbreds racing on the flat. Quantifying and describing common injuries and health conditions affecting racehorses will enable targeted risk factor analysis aimed at reducing their occurrence. To describe the type and incidence of race-day veterinary events experienced by Thoroughbred racehorses participating in flat racing in the UK. Retrospective cohort study (2000 to 2013). Veterinary events recorded by race-day veterinarians were retrieved and linked to race start data. Race-day veterinary events were described by type, location and anatomical structure(s) affected and whether the outcome was fatal or not. Incidence per 1000 starts was calculated, both overall and by year. Stratified incidence rates were calculated for selected event categories by specific course- and horse-level variables. There were 7993 events experienced by 6727 horses, with an incidence of 9.37 events per 1000 starts. Soft tissue injuries other than tendon and ligament injuries were the most commonly occurring veterinary events (24.1%), followed by gait observations (21.2%) and respiratory conditions (21.2%). In total, 13.8% of events were bone injuries. The incidence of fatality (n = 628) was 0.76 per 1000 starts. Most (485/628, 77.2%) fatal events were bone injuries, 64 were due to cardiac conditions and 54 due to tendon and ligament injuries. All-weather tracks had a higher incidence of veterinary events and fatalities than turf tracks. Firmer (turf) or faster (all-weather) going were associated with a higher incidence of all veterinary events. Events were based on presumptive, rather than definitive, veterinary diagnosis. The most common events experienced by racehorses on race-day were relatively minor and not career-ending. Although more severe bone, joint, tendon and ligament injuries were less common, they had a greater impact on whether the outcome of the event was fatal. © 2016 EVJ Ltd.

  8. A Methodology to Improving Unity of Effort for Mission Partner Planning

    DTIC Science & Technology

    2014-06-01

    REPORT TYPE 3. DATES COVERED 00-00-2014 to 00-00-2014 4. TITLE AND SUBTITLE A Methodology to Improving Unity of Effort for Mission Partner... language , or better yet, use a common lexicon (common definitions and terms for greater understanding). One fundamental step toward developing...to attempt to develop strong relationships while learning to speak each other’s language , or better yet, use a common lexicon (common definitions and

  9. Radiocarbon dating of terrestrial carbonates

    USGS Publications Warehouse

    Pigati, Jeffrey S.; Rink, W. Jack; Thompson, Jeroen

    2014-01-01

    Terrestrial carbonates encompass a wide range of materials that potentially could be used for radiocarbon (14C) dating. Biogenic carbonates, including shells and tests of terrestrial and aquatic gastropods, bivalves, ostracodes, and foraminifera, are preserved in a variety of late Quaternary deposits and may be suitable for 14C dating. Primary calcareous deposits (marls, tufa, speleothems) and secondary carbonates (rhizoliths, fracture fill, soil carbonate) may also be targeted for dating when conditions are favorable. This chapter discusses issues that are commonly encountered in 14C dating of terrestrial carbonates, including isotopic disequilibrium and open-system behavior, as well as methods used to determine the reliability of ages derived from these materials. Recent methodological advancements that may improve the accuracy and precision of 14C ages of terrestrial carbonates are also highlighted.

  10. Improving Access to Eye Care: Teleophthalmology in Alberta, Canada

    PubMed Central

    Ng, ManCho; Nathoo, Nawaaz; Rudnisky, Chris J.; Tennant, Matthew T. S.

    2009-01-01

    Backround Diabetic retinopathy in Alberta and throughout Canada is common, with a prevalence up to 40% in people with diabetes. Unfortunately, due to travel distance, time, and expense, a third of patients with diabetes do not receive annual dilated eye examinations by ophthalmologists, despite universal health care access. In an effort to improve access, a teleophthalmology program was developed to overcome barriers to eye care. Prior to clinical implementation, teleophthalmology technology was clinically validated for the identification of treatable levels of diabetic retinopathy. Method Patients undergoing a teleophthalmology assessment underwent stereoscopic digital retinal photographs following pupillary dilation. Digital images were then packaged into an encrypted password-protected compressed file for uploading onto a secure server. Images were digitally unpackaged for review as a stereoscopic digital slide show and graded with a modified Early Treatment Diabetic Retinopathy Study algorithm. Reports were then generated automatically as a PDF file and sent back to the referring physician. Results Teleophthalmology programs in Alberta have assessed more than 5500 patients (9016 visits) to date. Nine hundred thirty patients have been referred for additional testing or treatment. Approximately 2% of teleophthalmology assessments have required referral for in-person examination due to ungradable image sets, most commonly due to cataract, corneal drying, or asteroid hyalosis. Conclusions In Alberta and throughout Canada, many patients with diabetes do not receive an annual dilated eye examination. Teleophthalmology is beneficial because patients can be assessed within their own communities. This decreases the time to treatment, allows treated patients to be followed remotely, and prevents unnecessary referrals. Health care costs may be reduced by the introduction of comprehensive teleophthalmology examinations by enabling testing and treatment to be planned prior to the patient's first visit. PMID:20144360

  11. Improving access to eye care: teleophthalmology in Alberta, Canada.

    PubMed

    Ng, Mancho; Nathoo, Nawaaz; Rudnisky, Chris J; Tennant, Matthew T S

    2009-03-01

    Diabetic retinopathy in Alberta and throughout Canada is common, with a prevalence up to 40% in people with diabetes. Unfortunately, due to travel distance, time, and expense, a third of patients with diabetes do not receive annual dilated eye examinations by ophthalmologists, despite universal health care access. In an effort to improve access, a teleophthalmology program was developed to overcome barriers to eye care. Prior to clinical implementation, teleophthalmology technology was clinically validated for the identification of treatable levels of diabetic retinopathy. Patients undergoing a teleophthalmology assessment underwent stereoscopic digital retinal photographs following pupillary dilation. Digital images were then packaged into an encrypted password-protected compressed file for uploading onto a secure server. Images were digitally unpackaged for review as a stereoscopic digital slide show and graded with a modified Early Treatment Diabetic Retinopathy Study algorithm. Reports were then generated automatically as a PDF file and sent back to the referring physician. Teleophthalmology programs in Alberta have assessed more than 5500 patients (9016 visits) to date. Nine hundred thirty patients have been referred for additional testing or treatment. Approximately 2% of teleophthalmology assessments have required referral for in-person examination due to ungradable image sets, most commonly due to cataract, corneal drying, or asteroid hyalosis. In Alberta and throughout Canada, many patients with diabetes do not receive an annual dilated eye examination. Teleophthalmology is beneficial because patients can be assessed within their own communities. This decreases the time to treatment, allows treated patients to be followed remotely, and prevents unnecessary referrals. Health care costs may be reduced by the introduction of comprehensive teleophthalmology examinations by enabling testing and treatment to be planned prior to the patient's first visit. (c) 2009 Diabetes Technology Society.

  12. A Protection Motivation Theory application to date rape education.

    PubMed

    Singh, Shweta; Orwat, John; Grossman, Susan

    2011-12-01

    Date rape risk communication is a key component of education-based Date Rape Prevention Programs, common across colleges. In such programs, risk assessment in date rape is approached cautiously in order to avoid a tone of "victim blaming." Since it is important in the assessment of any risk to understand the surrounding social context of the risky situation and the individual's unique relationship with that social context, this study examines Protection Motivation Theory as it applies to handling the risk of date rape without victim blaming. The paper links individual personality and social contexts with risk communication. The study sample comprised 367 undergraduate women enrolled in a large Southern Public University. The study examines the relationships between dating activity, social competency, and type of information provided with the dependents variables of date rape related protection behavior (intent), belief, and knowledge. A factorial multiple analysis of covariance analysis found that the dependent variables had a significant relationship with aspects of social competency and dating activity. The exposure to varying information about date rape was not significantly related to the dependent variables of date rape-related protection behavior (intent), belief, and knowledge. The identification of social competency and dating activity status as protective factors in this study makes a significant contribution to the practice and research efforts in date rape education.

  13. Methods for using argon-39 to age-date groundwater using ultra-low-background proportional counting

    DOE PAGES

    Mace, Emily; Aalseth, Craig; Brandenberger, Jill; ...

    2016-12-21

    Argon-39 can be used as a tracer for age-dating glaciers, oceans, and more recently, groundwater. With a half-life of 269 years, 39Ar fills an intermediate age range gap (50–1,000 years) not currently covered by other common groundwater tracers. Therefore, adding this tracer to the data suite for groundwater studies provides an important tool for improving our understanding of groundwater systems. Lastly, we present the methods employed for arriving at an age-date for a given sample of argon degassed from groundwater.

  14. Methods for using argon-39 to age-date groundwater using ultra-low-background proportional counting

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mace, Emily; Aalseth, Craig; Brandenberger, Jill

    Argon-39 can be used as a tracer for age-dating glaciers, oceans, and more recently, groundwater. With a half-life of 269 years, 39Ar fills an intermediate age range gap (50-1,000 years) not currently covered by other common groundwater tracers. Therefore, adding this tracer to the data suite for groundwater studies provides an important tool for improving our understanding of groundwater systems. We present the methods employed for arriving at an age-date for a given sample of argon degassed from groundwater.

  15. Methods for using argon-39 to age-date groundwater using ultra-low-background proportional counting

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mace, Emily; Aalseth, Craig; Brandenberger, Jill

    Argon-39 can be used as a tracer for age-dating glaciers, oceans, and more recently, groundwater. With a half-life of 269 years, 39Ar fills an intermediate age range gap (50–1,000 years) not currently covered by other common groundwater tracers. Therefore, adding this tracer to the data suite for groundwater studies provides an important tool for improving our understanding of groundwater systems. Lastly, we present the methods employed for arriving at an age-date for a given sample of argon degassed from groundwater.

  16. 78 FR 19476 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-01

    .... Applicants: Vineland Energy LLC. Description: Vineland Energy LLC submits Triennial Market Based Rate Update... January 29, 2013 notice of succession. Filed Date: 3/19/13. Accession Number: 20130319-5083. Comments Due... Wholesale Market Participation Agreement No. 2404. Filed Date: 3/25/13. Accession Number: 20130325-5070...

  17. 77 FR 38474 - Amendment of Class E Airspace; Livingston, MT

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-28

    ... (IFR) operations at the airport. Also, the geographic coordinates of the airport are updated at the request of National Aeronautical Navigation Services. DATES: Effective date, 0901 UTC, September 20, 2012... necessary due to the decommissioning of the Livingston TACAN. Also, the geographic coordinates of the...

  18. 20 CFR 725.608 - Interest.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... simple annual interest, computed from the date on which the benefits were due. The interest shall be... payment of retroactive benefits, the beneficiary shall also be entitled to simple annual interest on such... entitled to simple annual interest computed from the date upon which the beneficiary's right to additional...

  19. 77 FR 53194 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-31

    ... Market Based Tariff filings. Filed Date: 8/17/12. Accession Number: 20120817-5103. Comments Due: 5 p.m..., 2012 Application for market-based rate authorization. Filed Date: 8/17/12. Accession Number: 20120817... Wholesale, LLC. Description: Amendment to Application for Market-Based Rate Authority of Energy Alternatives...

  20. CRISPR/Cas9: A Practical Approach in Date Palm Genome Editing

    PubMed Central

    Sattar, Muhammad N.; Iqbal, Zafar; Tahir, Muhammad N.; Shahid, Muhammad S.; Khurshid, Muhammad; Al-Khateeb, Abdullatif A.; Al-Khateeb, Suliman A.

    2017-01-01

    The genetic modifications through breeding of crop plants have long been used to improve the yield and quality. However, precise genome editing (GE) could be a very useful supplementary tool for improvement of crop plants by targeted genome modifications. Various GE techniques including ZFNs (zinc finger nucleases), TALENs (transcription activator-like effector nucleases), and most recently clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 (CRISPR-associated protein 9)-based approaches have been successfully employed for various crop plants including fruit trees. CRISPR/Cas9-based approaches hold great potential in GE due to their simplicity, competency, and versatility over other GE techniques. However, to the best of our knowledge no such genetic improvement has ever been developed in date palm—an important fruit crop in Oasis agriculture. The applications of CRISPR/Cas9 can be a challenging task in date palm GE due to its large and complex genome, high rate of heterozygosity and outcrossing, in vitro regeneration and screening of mutants, high frequency of single-nucleotide polymorphism in the genome and ultimately genetic instability. In this review, we addressed the potential application of CRISPR/Cas9-based approaches in date palm GE to improve the sustainable date palm production. The availability of the date palm whole genome sequence has made it feasible to use CRISPR/Cas9 GE approach for genetic improvement in this species. Moreover, the future prospects of GE application in date palm are also addressed in this review. PMID:28878801

  1. CRISPR/Cas9: A Practical Approach in Date Palm Genome Editing.

    PubMed

    Sattar, Muhammad N; Iqbal, Zafar; Tahir, Muhammad N; Shahid, Muhammad S; Khurshid, Muhammad; Al-Khateeb, Abdullatif A; Al-Khateeb, Suliman A

    2017-01-01

    The genetic modifications through breeding of crop plants have long been used to improve the yield and quality. However, precise genome editing (GE) could be a very useful supplementary tool for improvement of crop plants by targeted genome modifications. Various GE techniques including ZFNs (zinc finger nucleases), TALENs (transcription activator-like effector nucleases), and most recently clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 (CRISPR-associated protein 9)-based approaches have been successfully employed for various crop plants including fruit trees. CRISPR/Cas9-based approaches hold great potential in GE due to their simplicity, competency, and versatility over other GE techniques. However, to the best of our knowledge no such genetic improvement has ever been developed in date palm-an important fruit crop in Oasis agriculture. The applications of CRISPR/Cas9 can be a challenging task in date palm GE due to its large and complex genome, high rate of heterozygosity and outcrossing, in vitro regeneration and screening of mutants, high frequency of single-nucleotide polymorphism in the genome and ultimately genetic instability. In this review, we addressed the potential application of CRISPR/Cas9-based approaches in date palm GE to improve the sustainable date palm production. The availability of the date palm whole genome sequence has made it feasible to use CRISPR/Cas9 GE approach for genetic improvement in this species. Moreover, the future prospects of GE application in date palm are also addressed in this review.

  2. Self-Help Service Center Management System User’s Manual: Version 2.1

    DTIC Science & Technology

    1991-06-01

    tools and other equipment loaned to customers. Temporary nonconsumable items, such as lawn mowers , must be returned by a certain due date a’nd time...function to process the return of lawn mowers . 3. A capability to identify the status of and/or process the return of a single borrowed item. This would be...IiR Qty Due Date Time 00000035 LAWN MOWER T I 1 03/09/90 18:00 Message Box ILocation Available: 10 Aisle: Authorized for item. I Row: Bin: Enter T for

  3. The Relationship between Balancing Reactions and Reaction Lifetimes: A Consideration of the Potassium-Argon Radiometric Method for Dating Minerals

    ERIC Educational Resources Information Center

    Howard, William A.

    2005-01-01

    A detailed examination of a commonly accepted practice in geology offers an example of how to stimulate critical thinking, teaches students how to read reactions, and challenges students to formulate better experiments for determining mineral ages more accurately. A demonstration of a Potassium-Argon radiometric method for dating minerals is…

  4. A map of single nucleotide polymorphisms of the date palm (Phoenix dactylifera) based on whole genome sequencing of 62 varieties

    USDA-ARS?s Scientific Manuscript database

    Date palm is one of the few crop species that thrive in arid environments and are the most significant fruit crop in the Middle East and North Africa, but lacks genomic resources that can accelerate breeding efforts. Here, we present the first comprehensive catalogue of ~12 million common single nuc...

  5. 78 FR 44028 - Review of Foreign Ownership Policies for Common Carrier and Aeronautical Radio Licensees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... Foreign Ownership Policies for Common Carrier and Aeronautical Radio Licensees AGENCY: Federal... route and aeronautical fixed radio station licensees. DATES: Effective on August 9, 2013. FOR FURTHER... following corrections are made: Subpart F--Wireless Radio Services Applications and Proceedings [Corrected...

  6. Problems in archaeomagnetic reference curves elaboration in the prehistoric past.

    NASA Astrophysics Data System (ADS)

    Avramova, M.; Kovacheva, M.; Boyadziev, Y.

    2012-04-01

    Most important task of archaeomagnetic studies is the construction of the geomagnetic field secular variations in the past for a given territory. The obtained reference curves would be precise only when a large number of well-dated archaeological sites from different time periods are included as input data. Sofia Palaeomagnetic laboratory is the first one in the Balkans to accumulate a large number of data spanning the time interval of 3000 BP to 8000 BP. Many archaeological sites in Bulgaria are multilevel settlements with clear stratigraphy. Commonly the prehistoric sites are dated according to the relative chronology, the type of archaeological artifacts found and 14C dates, the latter being not always available. The biggest difficulty is that usually the radiocarbon dates are not well constrained, often contradictory to the vertical stratigraphy. The transformation of conventional 14C dates to absolute dates BC depends a lot on which part of dendrochronological calibration curve are they related. Besides, multiple dating intervals are often obtained and the calibrated intervals are usually very large (from 100 to 300 and more years). However, when archaeological discoveries of multilevel prehistoric sites are combined with archaeomagnetic investigations the corresponding archaeomagnetic profiles can be obtained. Currently we have archaeomagnetic data for fifteen prehistoric multilevel sites - two of them are Neolithic, nine - Eneolithic and four are from the Bronze Age. The next step is to juxtapose these stratigraphic profiles with the absolute scale of time having in mind that not all sites and layers have 14C dates. Thanks to abundance of 14C dates for most of Bulgarian prehistoric sites, multilayer sites connected with the absolute chronology exist and can be used as reference profiles. The time frames of each horizon for such reference site are based on series of 14C dates (not single measurements), the analysis of the thickness of layers, type of material dated (perennial or annual) and cultural features. An example for such reference profile is the multilevel site Yunatzite from the Early Bronze Age. The comparison of archaeomagnetic profile Yunatzite with another archaeomagnetically studied Early Bronze Age multilevel site Djadovo shows very good agreement. Comparisons of other archaeomagnetic profiles available for Bulgaria related to the same epoch or sub-epoch will be presented. The expected correspondence can help the refinement of chronology of sites having only stratigraphic profiles. In our opinion the observed discrepancies between the local PSVCs for a given geographical region might be due mainly to the above described difficulties for elaboration of these curves in the prehistory. The further refinement and updating of existing archaeomagnetic databases will help considerably the elaboration of the newest geomagnetic field models. Acknowledgement: A partial financial support is from the Project "The archaeomagnetism - a key for solving fundamental problems in geophysics and archaeology", granted from the Bulgarian National Science Fund.

  7. [Pathophysiology of myopia: nature versus nurture].

    PubMed

    Cassagne, M; Malecaze, F; Soler, V

    2014-05-01

    Myopia is the most frequent refractive disorder in the world. It has become a real Public Health problem, due to its frequency and to high myopia-related blinding complications. Myopic progression depends on genetic and environmental factors. Genetic studies have identified more than forty candidate genes that take part in pathophysiological pathways, from retinal phototransduction to axial lengthening via scleral remodelling. Environmental factors also influence scleral remodelling by way of visual perception. In the case of predominant attention to near tasks, a physiological feedback loop leads to axial growth. This phenomenon, called active emmetropization, is particularly obvious in animal models and in some human populations. To date, research has failed to identify a molecule common to all the implicated metabolic pathways which could be a target for an effective preventive treatment against myopic progression. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  8. Measuring use of electronic health record functionality using system audit information.

    PubMed

    Bowes, Watson A

    2010-01-01

    Meaningful and efficient methods for measuring Electronic Health Record (EHR) adoption and functional usage patterns have recently become important for hospitals, clinics, and health care networks in the United State due to recent government initiatives to increase EHR use. To date, surveys have been the method of choice to measure EHR adoption. This paper describes another method for measuring EHR adoption which capitalizes on audit logs, which are often common components of modern EHRs. An Audit Data Mart is described which identified EHR functionality within 836 Departments, within 22 Hospitals and 170 clinics at Intermountain Healthcare, a large integrated delivery system. The Audit Data Mart successfully identified important and differing EHR functional usage patterns. These patterns were useful in strategic planning, tracking EHR implementations, and will likely be utilized to assist in documentation of "Meaningful Use" of EHR functionality.

  9. Healthy mental ageing.

    PubMed

    Flicker, Leon; Lautenschlager, Nicola T; Almeida, Osvaldo P

    2006-09-01

    Healthy mental ageing may be defined as the absence of the common disabling mental health problems of older people, especially cognitive decline and depression, accompanied by the perception of a positive quality of life. Older people are particularly prone to negative effects on mental health due to poor physical health. Modifiable aspects of lifestyle have been shown to be associated with healthy mental ageing. These include increased physical activity, intellectual stimulation (including education), avoidance of smoking and various aspects of diet. There is reasonably strong evidence that the treatment of hypertension will decrease the risk of cognitive impairment, and moderate alcohol intake may also have some benefits on cognition. These modifiable lifestyle factors may benefit from deliberate individual and population health promotion strategies to maximize mental health in old age, although to date intervention trials have not been performed to support the evidence obtained from observational studies.

  10. New analytic results for speciation times in neutral models.

    PubMed

    Gernhard, Tanja

    2008-05-01

    In this paper, we investigate the standard Yule model, and a recently studied model of speciation and extinction, the "critical branching process." We develop an analytic way-as opposed to the common simulation approach-for calculating the speciation times in a reconstructed phylogenetic tree. Simple expressions for the density and the moments of the speciation times are obtained. Methods for dating a speciation event become valuable, if for the reconstructed phylogenetic trees, no time scale is available. A missing time scale could be due to supertree methods, morphological data, or molecular data which violates the molecular clock. Our analytic approach is, in particular, useful for the model with extinction, since simulations of birth-death processes which are conditioned on obtaining n extant species today are quite delicate. Further, simulations are very time consuming for big n under both models.

  11. Identifying the Basal Angiosperm Node in Chloroplast GenomePhylogenies: Sampling One's Way Out of the Felsenstein Zone

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Leebens-Mack, Jim; Raubeson, Linda A.; Cui, Liying

    2005-05-27

    While there has been strong support for Amborella and Nymphaeales (water lilies) as branching from basal-most nodes in the angiosperm phylogeny, this hypothesis has recently been challenged by phylogenetic analyses of 61 protein-coding genes extracted from the chloroplast genome sequences of Amborella, Nymphaea and 12 other available land plant chloroplast genomes. These character-rich analyses placed the monocots, represented by three grasses (Poaceae), as sister to all other extant angiosperm lineages. We have extracted protein-coding regions from draft sequences for six additional chloroplast genomes to test whether this surprising result could be an artifact of long-branch attraction due to limited taxonmore » sampling. The added taxa include three monocots (Acorus, Yucca and Typha), a water lily (Nuphar), a ranunculid(Ranunculus), and a gymnosperm (Ginkgo). Phylogenetic analyses of the expanded DNA and protein datasets together with microstructural characters (indels) provided unambiguous support for Amborella and the Nymphaeales as branching from the basal-most nodes in the angiospermphylogeny. However, their relative positions proved to be dependent on method of analysis, with parsimony favoring Amborella as sister to all other angiosperms, and maximum likelihood and neighbor-joining methods favoring an Amborella + Nympheales clade as sister. The maximum likelihood phylogeny supported the later hypothesis, but the likelihood for the former hypothesis was not significantly different. Parametric bootstrap analysis, single gene phylogenies, estimated divergence dates and conflicting in del characters all help to illuminate the nature of the conflict in resolution of the most basal nodes in the angiospermphylogeny. Molecular dating analyses provided median age estimates of 161 mya for the most recent common ancestor of all extant angiosperms and 145 mya for the most recent common ancestor of monocots, magnoliids andeudicots. Whereas long sequences reduce variance in branch lengths and molecular dating estimates, the impact of improved taxon sampling on the rooting of the angiosperm phylogeny together with the results of parametric bootstrap analyses demonstrate how long-branch attraction can mislead genome-scale phylogenetic analyses.« less

  12. Burying Dogs in Ancient Cis-Baikal, Siberia: Temporal Trends and Relationships with Human Diet and Subsistence Practices

    PubMed Central

    Losey, Robert J.; Garvie-Lok, Sandra; Leonard, Jennifer A.; Katzenberg, M. Anne; Germonpré, Mietje; Nomokonova, Tatiana; Sablin, Mikhail V.; Goriunova, Olga I.; Berdnikova, Natalia E.; Savel’ev, Nikolai A.

    2013-01-01

    The first objective of this study is to examine temporal patterns in ancient dog burials in the Lake Baikal region of Eastern Siberia. The second objective is to determine if the practice of dog burial here can be correlated with patterns in human subsistence practices, in particular a reliance on terrestrial mammals. Direct radiocarbon dating of a suite of the region’s dog remains indicates that these animals were given burial only during periods in which human burials were common. Dog burials of any kind were most common during the Early Neolithic (∼7–8000 B.P.), and rare during all other time periods. Further, only foraging groups seem to have buried canids in this region, as pastoralist habitation sites and cemeteries generally lack dog interments, with the exception of sacrificed animals. Stable carbon and nitrogen isotope data indicate that dogs were only buried where and when human diets were relatively rich in aquatic foods, which here most likely included river and lake fish and Baikal seal (Phoca sibirica). Generally, human and dog diets appear to have been similar across the study subregions, and this is important for interpreting their radiocarbon dates, and comparing them to those obtained on the region’s human remains, both of which likely carry a freshwater old carbon bias. Slight offsets were observed in the isotope values of dogs and humans in our samples, particularly where both have diets rich in aquatic fauna. This may result from dietary differences between people and their dogs, perhaps due to consuming fish of different sizes, or even different tissues from the same aquatic fauna. This paper also provides a first glimpse of the DNA of ancient canids in Northeast Asia. PMID:23696851

  13. Age and origin of two common MLH1 mutations predisposing to hereditary colon cancer.

    PubMed

    Moisio, A L; Sistonen, P; Weissenbach, J; de la Chapelle, A; Peltomäki, P

    1996-12-01

    Two mutations in the DNA mismatch repair gene MLH1, referred to as mutations 1 and 2, are frequent among Finnish kindreds with hereditary nonpolyposis colorectal cancer (HNPCC). In order to assess the ages and origins of these mutations, we constructed a map of 15 microsatellite markers around MLH1 and used this information in haplotype analyses of 19 kindreds with mutation 1 and 6 kindreds with mutation 2. All kindreds with mutation 1 showed a single allele for the intragenic marker D3S1611 that was not observed on any unaffected chromosome. They also shared portions of a haplotype of 4-15 markers encompassing 2.0-19.0 cM around MLH1. All kindreds with mutation 2 shared another allele for D3S1611 and a conserved haplotype of 5-14 markers spanning 2.0-15.0 cM around MLH1. The degree of haplotype conservation was used to estimate the ages of these two mutations. While some recessive disease genes have been estimated to have existed and spread for as long as thousands of generations worldwide and hundreds of generations in the Finnish population, our analyses suggest that the spread of mutation 1 started 16-43 generations (400-1,075 years) ago and that of mutation 2 some 5-21 generations (125-525 years) ago. These datings are compatible with our genealogical results identifying a common ancestor born in the 16th and 18th century, respectively. Overall, our results indicate that all Finnish kindreds studied to date showing either mutation 1 or mutation 2 are due to single ancestral founding mutations relatively recent in origin in the population. Alternatively, the mutations arose elsewhere earlier and were introduced in Finland more recently.

  14. Preoperative chemoradiation with paclitaxel-carboplatin or with fluorouracil-oxaliplatin-folinic acid (FOLFOX) for resectable esophageal and junctional cancer: the PROTECT-1402, randomized phase 2 trial.

    PubMed

    Messager, Mathieu; Mirabel, Xavier; Tresch, Emmanuelle; Paumier, Amaury; Vendrely, Véronique; Dahan, Laetitia; Glehen, Olivier; Vasseur, Frederique; Lacornerie, Thomas; Piessen, Guillaume; El Hajbi, Farid; Robb, William B; Clisant, Stéphanie; Kramar, Andrew; Mariette, Christophe; Adenis, Antoine

    2016-05-18

    Often curative treatment for locally advanced resectable esophageal or gastro-esophageal junctional cancer consists of concurrent neoadjuvant radiotherapy and chemotherapy followed by surgery. Currently, one of the most commonly used chemotherapy regimens in this setting is a combination of a fluoropyrimidin and of a platinum analogue. Due to the promising results of the recent CROSS trial, another regimen combining paclitaxel and carboplatin is also widely used by European and American centers. No clinical study has shown the superiority of one treatment over the other. The objective of this Phase II study is to clarify clinical practice by comparing these two chemotherapy treatments. Our aim is to evaluate, in operable esophageal and gastro-esophageal junctional cancer, the complete resection rate and severe postoperative morbidity rate associated with these two neoadjuvant chemotherapeutic regimens (carboplatin-paclitaxel or fluorouracil-oxaliplatin-folinic acid) when each is combined with the radiation regime utilized in the CROSS trial. PROTECT is a prospective, randomized, multicenter, open arms, phase II trial. Eligible patients will have a histologically confirmed adenocarcinoma or squamous cell carcinoma and be treated with neoadjuvant radiochemotherapy followed by surgery for stage IIB or stage III resectable esophageal cancer. A total of 106 patients will be randomized to receive either 3 cycles of FOLFOX combined to concurrent radiotherapy (41.4 Grays) or carboplatin and paclitaxel with the same radiation regimen, using a 1:1 allocation ratio. This ongoing trial offers the unique opportunity to compare two standards of chemotherapy delivered with a common regimen of preoperative radiation, in the setting of operable locally advanced esophageal or gastro-esophageal junctional tumors. NCT02359968 (ClinicalTrials.gov) (registration date: 9 FEB 2015), EudraCT: 2014-000649-62 (registration date: 10 FEB 2014).

  15. 7 CFR 3560.452 - Monetary and non-monetary defaults.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... requirements, including requirements imposed on a borrower through a workout agreement developed in accordance... agreement, workout agreement, or other agreement remains due more than 30 days after the due date. (c...

  16. 7 CFR 3560.452 - Monetary and non-monetary defaults.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... requirements, including requirements imposed on a borrower through a workout agreement developed in accordance... agreement, workout agreement, or other agreement remains due more than 30 days after the due date. (c...

  17. Comparative Chromosome Map and Heterochromatin Features of the Gray Whale Karyotype (Cetacea).

    PubMed

    Kulemzina, Anastasia I; Proskuryakova, Anastasia A; Beklemisheva, Violetta R; Lemskaya, Natalia A; Perelman, Polina L; Graphodatsky, Alexander S

    2016-01-01

    Cetacean karyotypes possess exceptionally stable diploid numbers and highly conserved chromosomes. To date, only toothed whales (Odontoceti) have been analyzed by comparative chromosome painting. Here, we studied the karyotype of a representative of baleen whales, the gray whale (Eschrichtius robustus, Mysticeti), by Zoo-FISH with dromedary camel and human chromosome-specific probes. We confirmed a high degree of karyotype conservation and found an identical order of syntenic segments in both branches of cetaceans. Yet, whale chromosomes harbor variable heterochromatic regions constituting up to a third of the genome due to the presence of several types of repeats. To investigate the cause of this variability, several classes of repeated DNA sequences were mapped onto chromosomes of whale species from both Mysticeti and Odontoceti. We uncovered extensive intrapopulation variability in the size of heterochromatic blocks present in homologous chromosomes among 3 individuals of the gray whale by 2-step differential chromosome staining. We show that some of the heteromorphisms observed in the gray whale karyotype are due to distinct amplification of a complex of common cetacean repeat and heavy satellite repeat on homologous autosomes. Furthermore, we demonstrate localization of the telomeric repeat in the heterochromatin of both gray and pilot whale (Globicephala melas, Odontoceti). Heterochromatic blocks in the pilot whale represent a composite of telomeric and common repeats, while heavy satellite repeat is lacking in the toothed whale consistent with previous studies. © 2016 S. Karger AG, Basel.

  18. The use of luminescence for dating young volcanic eruptions

    NASA Astrophysics Data System (ADS)

    Schmidt, Christoph; Schaarschmidt, Maria; Kolb, Thomas; Richter, Daniel; Tchouankoue, Jean Pierre; Zöller, Ludwig

    2017-04-01

    Reliable chronologies of volcanic eruptions are vital for hazard analysis, but dating of Holocene and Late Pleistocene volcanism poses a major challenge. Established techniques such as 40Ar/39Ar are often problematic due to the long half-life of 40K or the absence of datable materials. In this context, luminescence dating methods are an alternative since they are applicable to Earth's most common minerals and to a range of different datable events. Luminescence signal resetting during volcanic activity can be caused by heat (lava, contact to lava), light (disintegration of ejecta) or (temperature-assisted) pressure in the course of phreatomagmatic explosions. While volcanogenic minerals assembling basalt or other volcanic rocks are less suitable for luminescence dating due to so-called anomalous fading, the signal of volcanogenically heated or fragmented country rock actually relates to the time of eruption as well and further provides reproducible results. This contribution aims to illustrate the potential of this latter approach by presenting two case studies. The first refers to two Late Pleistocene scoria cones in the Westeifel Volcanic Field (WEVF), Germany, of which the Wartgesberg locality was dated by 40Ar/39Ar and 14C, while the closeby Facher Höhe is chronologically poorly constrained (Mertz et al. 2015; pers comm. Luise Eichhorn, 2016). The former locality allows testing the accuracy of various luminescence techniques (thermoluminescence, TL, optically stimulated luminescence, OSL, infrared stimulated luminescence, IRSL) applied to quartz and feldspar against independent age control. The other study site is the monogenetic Lake Nyos Maar as part of the Cameroon Volcanic Line, having killed 1,700 people in 1986 following the release of large amounts of CO2. Previous dating efforts of the last explosive activity are inconsistent and yielded age estimates ranging from 400 a (14C) to >350 ka (K-Ar) (Aka et al. 2008). Our results demonstrate that multiple luminescence methods (TL, OSL) yield equally valid age estimates averaging to 33.6 ± 2.4 ka for the Wartgesberg site, in good agreement with 40Ar/39Ar and 14C results. The Facher Höhe, however, is much younger than previously expected with an average TL age of 15.5 ± 1.1 ka. This southeastern part of the WEVF thus hosts many of the most recent eruption sites, which has important implications for studying the causes of Eifel volcanism but also for assessing future eruption locations. Preliminary findings suggest that the phreatomagmatic explosion of the Nyos Maar was capable of completely resetting the inherited luminescence signal and indicate a significant overestimation by K-Ar. References Aka, F.T., Yokoyama, T., Kusakabe, M., Nakamura, E., Tanyileke, G., Ateba, B., Ngako, V., Nnange, J., Hell, J., 2008. U-series dating of Lake Nyos maar basalts, Cameroon (West Africa): Implications for potential hazards on the Lake Nyos dam. Journal of Volcanology and Geothermal Research 176, 212-224. Mertz, D.F., Löhnertz, W., Nomade, S., Pereira, A., Prelevic, D., Renne, P.R., 2015. Temporal-spatial evolution of low-SiO2 volcanism in the Pleistocene West Eifel volcanic field (West Germany) and relationship to upwelling asthenosphere. Journal of Geodynamics 88, 59-79.

  19. Hunting for eruption ages in accessory minerals

    NASA Astrophysics Data System (ADS)

    Vazquez, J. A.

    2012-12-01

    A primary goal in geochronology is to provide precise and accurate ages for tephras that serve as chronostratigraphic markers for constraining the timing and rates of volcanism, sedimentation, climate change, and catastrophic events in Earth history. Zircon remains the most versatile accessory mineral for dating silicic tephras due to its common preservation in distal pyroclastic deposits, as well as the robustness of its U-Pb and U-series systems even after host materials have been hydrothermally altered or weathered. Countless studies document that zircon may be complexly zoned in age due to inheritance, contamination, recycling of antecrysts, protracted crystallization in long-lived magma reservoirs, or any combination of these. Other accessory minerals such as allanite or chevkinite can retain similar records of protracted crystallization. If the goal is to date the durations of magmatic crystallization, differentiation, and/or magma residence, then these protracted chronologies within and between accessory minerals are a blessing. However, if the goal is to date the timing of eruption with high precision, i.e., absolute ages with millennial-scale uncertainties, then this age zoning is a curse. Observations from ion microprobe 238U-230Th dating of Pleistocene zircon and allanite provide insight into the record of near-eruption crystallization in accessory minerals and serve as a guide for high-precision whole-crystal dating. Although imprecise relative to conventional techniques, ion probe analysis allows high-spatial resolution 238U-230Th dating that can document multi-millennial age distributions at the crystal scale. Analysis of unpolished rims and continuous depth profiling of zircon from small and large volume eruptions (e.g., Coso, Mono Craters, Yellowstone) reveals that the final several micrometers of crystallization often yield ages that are indistinguishable from associated eruption ages from the 40Ar/39Ar or (U-Th)/He methods. Using this approach, we have derived relatively precise (± ~ 5%, 2σ) U-Th isochron ages from the unpolished rims of pumice-derived allanite and zircon from late Pleistocene Wilson Creek Formation tephras in eastern California, whose ages are controversial and have been difficult to resolve via 40Ar/39Ar and radiocarbon dating. Allanite and zircon rims from Ashes 7-19 in the lower portion of Wilson Creek sediments yield stratigraphically consistent ages of ca. 27 ka to ca. 62 ka, with a minority of crystals identifiable as xenocrysts from early Mono Craters rhyolites. Model ages for the interiors of allanite crystals are mostly < 10 k.y. older than their rims. Tephra deposited during the geomagnetic excursion debated to be either the Mono Lake or Laschamp event yields a rim isochron age of ca. 41 ka. This age is indistinguishable from an independent age of 41 ka derived at the latter excursion's type locality in France (Singer et al., 2009) as well as from age-models for deep-sea sediments. The results are in excellent agreement with a previously determined chronology derived from magnetostratigraphy (Zimmerman et al., 2006). Refs: Singer et al., 2009, EPSL 286: 80-88; Zimmerman et al., 2006, EPSL 252: 94-106

  20. A 3D high resolution ex vivo white matter atlas of the common squirrel monkey (saimiri sciureus) based on diffusion tensor imaging

    NASA Astrophysics Data System (ADS)

    Gao, Yurui; Parvathaneni, Prasanna; Schilling, Kurt G.; Wang, Feng; Stepniewska, Iwona; Xu, Zhoubing; Choe, Ann S.; Ding, Zhaohua; Gore, John C.; Chen, Li min; Landman, Bennett A.; Anderson, Adam W.

    2016-03-01

    Modern magnetic resonance imaging (MRI) brain atlases are high quality 3-D volumes with specific structures labeled in the volume. Atlases are essential in providing a common space for interpretation of results across studies, for anatomical education, and providing quantitative image-based navigation. Extensive work has been devoted to atlas construction for humans, macaque, and several non-primate species (e.g., rat). One notable gap in the literature is the common squirrel monkey - for which the primary published atlases date from the 1960's. The common squirrel monkey has been used extensively as surrogate for humans in biomedical studies, given its anatomical neuro-system similarities and practical considerations. This work describes the continued development of a multi-modal MRI atlas for the common squirrel monkey, for which a structural imaging space and gray matter parcels have been previously constructed. This study adds white matter tracts to the atlas. The new atlas includes 49 white matter (WM) tracts, defined using diffusion tensor imaging (DTI) in three animals and combines these data to define the anatomical locations of these tracks in a standardized coordinate system compatible with previous development. An anatomist reviewed the resulting tracts and the inter-animal reproducibility (i.e., the Dice index of each WM parcel across animals in common space) was assessed. The Dice indices range from 0.05 to 0.80 due to differences of local registration quality and the variation of WM tract position across individuals. However, the combined WM labels from the 3 animals represent the general locations of WM parcels, adding basic connectivity information to the atlas.

  1. A 3D high resolution ex vivo white matter atlas of the common squirrel monkey (Saimiri sciureus) based on diffusion tensor imaging

    PubMed Central

    Gao, Yurui; Parvathaneni, Prasanna; Schilling, Kurt G.; Wang, Feng; Stepniewska, Iwona; Xu, Zhoubing; Choe, Ann S.; Ding, Zhaohua; Gore, John C.; Chen, Li Min; Landman, Bennett A.; Anderson, Adam W.

    2016-01-01

    Modern magnetic resonance imaging (MRI) brain atlases are high quality 3-D volumes with specific structures labeled in the volume. Atlases are essential in providing a common space for interpretation of results across studies, for anatomical education, and providing quantitative image-based navigation. Extensive work has been devoted to atlas construction for humans, macaque, and several non-primate species (e.g., rat). One notable gap in the literature is the common squirrel monkey – for which the primary published atlases date from the 1960’s. The common squirrel monkey has been used extensively as surrogate for humans in biomedical studies, given its anatomical neuro-system similarities and practical considerations. This work describes the continued development of a multi-modal MRI atlas for the common squirrel monkey, for which a structural imaging space and gray matter parcels have been previously constructed. This study adds white matter tracts to the atlas. The new atlas includes 49 white matter (WM) tracts, defined using diffusion tensor imaging (DTI) in three animals and combines these data to define the anatomical locations of these tracks in a standardized coordinate system compatible with previous development. An anatomist reviewed the resulting tracts and the inter-animal reproducibility (i.e., the Dice index of each WM parcel across animals in common space) was assessed. The Dice indices range from 0.05 to 0.80 due to differences of local registration quality and the variation of WM tract position across individuals. However, the combined WM labels from the 3 animals represent the general locations of WM parcels, adding basic connectivity information to the atlas. PMID:27064328

  2. A 3D high resolution ex vivo white matter atlas of the common squirrel monkey (Saimiri sciureus) based on diffusion tensor imaging.

    PubMed

    Gao, Yurui; Parvathaneni, Prasanna; Schilling, Kurt G; Wang, Feng; Stepniewska, Iwona; Xu, Zhoubing; Choe, Ann S; Ding, Zhaohua; Gore, John C; Chen, Li Min; Landman, Bennett A; Anderson, Adam W

    2016-02-27

    Modern magnetic resonance imaging (MRI) brain atlases are high quality 3-D volumes with specific structures labeled in the volume. Atlases are essential in providing a common space for interpretation of results across studies, for anatomical education, and providing quantitative image-based navigation. Extensive work has been devoted to atlas construction for humans, macaque, and several non-primate species (e.g., rat). One notable gap in the literature is the common squirrel monkey - for which the primary published atlases date from the 1960's. The common squirrel monkey has been used extensively as surrogate for humans in biomedical studies, given its anatomical neuro-system similarities and practical considerations. This work describes the continued development of a multi-modal MRI atlas for the common squirrel monkey, for which a structural imaging space and gray matter parcels have been previously constructed. This study adds white matter tracts to the atlas. The new atlas includes 49 white matter (WM) tracts, defined using diffusion tensor imaging (DTI) in three animals and combines these data to define the anatomical locations of these tracks in a standardized coordinate system compatible with previous development. An anatomist reviewed the resulting tracts and the inter-animal reproducibility (i.e., the Dice index of each WM parcel across animals in common space) was assessed. The Dice indices range from 0.05 to 0.80 due to differences of local registration quality and the variation of WM tract position across individuals. However, the combined WM labels from the 3 animals represent the general locations of WM parcels, adding basic connectivity information to the atlas.

  3. 77 FR 12578 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-01

    ...-000. Applicants: Kawailoa Wind, LLC. Description: Notice of Self-Certification of Exempt Wholesale Generation Status of Kawailoa Wind, LLC. Filed Date: 2/21/12. Accession Number: 20120221-5272. Comments Due... Annual Adjustment to Traffic Light Costs to be effective 2/1/2012. Filed Date: 2/22/12. Accession Number...

  4. Science Newsletters

    ERIC Educational Resources Information Center

    Nall, Melissa

    2005-01-01

    Having students write and publish their own newsletters is a great way to integrate reading and writing, infuse technology, and build home/school relationships. These newsletters can be used to keep parents informed of what is being taught in class, important test dates, homework and project due dates, and any other information you'd like to…

  5. 77 FR 61776 - Notice of Submission of Proposed Information Collection to OMB Housing Counseling Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-11

    ... to evaluate grantees' performance. This collection of information includes renewal of various HUD... activities, client financial leverage data, and agency profile information. DATES: Comments Due Date... of information is necessary for the proper performance of the functions of the agency, including...

  6. 77 FR 57103 - Notice of Submission of Proposed Information Collection to OMB Housing Counseling Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... to evaluate grantees' performance. This collection of information includes renewal of various HUD... activities, client financial leverage data, and agency profile information. DATES: Comments Due Date: October... of information is necessary for the proper performance of the functions of the agency, including...

  7. 77 FR 35705 - Notice of Submission of Proposed Information Collection to OMB Request for Termination of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-14

    ... Proposed Information Collection to OMB Request for Termination of Multifamily Mortgage Insurance AGENCY... mutually agree to terminate the HUD multifamily mortgage insurance. DATES: Comments Due Date: July 16, 2012... following information: Title of Proposal: Request for Termination of Multifamily Mortgage Insurance. OMB...

  8. 76 FR 67470 - Notice of Submission of Proposed Information Collection to OMB; Energy Innovation Fund...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-01

    ... Proposed Information Collection to OMB; Energy Innovation Fund--Multifamily Energy Pilot Program AGENCY... proposals for increasing the energy efficiency of Multifamily Housing. DATES: Comments Due Date: December 1... following information: Title of Proposal: Energy Innovation Fund--Multifamily Energy Pilot Program. OMB...

  9. 25 CFR 11.1008 - Date of hearing.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... children's court shall set a date for the hearing which shall not be more than 15 days after the children's... motion of the presenting officer by reason of the unavailability of material evidence or witnesses and the children's court finds the presenting officer has exercised due diligence to obtain the material...

  10. 25 CFR 11.1008 - Date of hearing.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... children's court shall set a date for the hearing which shall not be more than 15 days after the children's... motion of the presenting officer by reason of the unavailability of material evidence or witnesses and the children's court finds the presenting officer has exercised due diligence to obtain the material...

  11. 25 CFR 11.1008 - Date of hearing.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... children's court shall set a date for the hearing which shall not be more than 15 days after the children's... motion of the presenting officer by reason of the unavailability of material evidence or witnesses and the children's court finds the presenting officer has exercised due diligence to obtain the material...

  12. 25 CFR 11.1008 - Date of hearing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... children's court shall set a date for the hearing which shall not be more than 15 days after the children's... motion of the presenting officer by reason of the unavailability of material evidence or witnesses and the children's court finds the presenting officer has exercised due diligence to obtain the material...

  13. 77 FR 20378 - Combined Notice of Filings #2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-04

    ... Generator Status of Ensign Wind, LLC. Filed Date: 3/27/12. Accession Number: 20120327-5056. Comments Due: 5... of Self-Certification of Exempt Wholesale Generator Status of Tuscola Bay Wind, LLC. Filed Date: 3/27.... Applicants: Minco Wind III, LLC. Description: Notice of Self-Certification of Exempt Wholesale Generator...

  14. 75 FR 17942 - Public Housing Contracting With Resident-Owned Businesses/Application Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-08

    ... Reduction Act. The Department is soliciting public comments on the subject proposal. Public Housing Agencies... contract award itself under the Department's procurement requirements. DATES: Comments Due Date: May 10... INFORMATION: This notice informs the public that the Department of Housing and Urban Development has submitted...

  15. 77 FR 19657 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-02

    ... Power Supply Cooperative, Inc. Filed Date: 3/16/12. Accession Number: 20120316-5102. Comments Due: 5 p.m... their Application for Approval under Section 203 of the Federal Power Act and Request for Expedited... Filing, Oklahoma Municipal Power Authority Letter Agreement to be effective N/A. Filed Date: 3/20/12...

  16. 77 FR 3278 - Notice of Proposed Information Collection: Multifamily Supplemental Information to Application...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-23

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5607-N-01] Notice of Proposed... the Assistant Secretary for Housing--Federal Housing Commissioner, HUD. ACTION: Notice. SUMMARY: The... public comments on the subject proposal. DATES: Comments Due Date: March 23, 2012. ADDRESSES: Interested...

  17. 75 FR 59284 - Notice of Submission of Proposed Information Collection to OMB; Financial Standards for Housing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ... (PHAs) could purchase insurance coverage without regard to competitive selection procedures, if the insurance was purchased from a nonprofit insurance entity owned and controlled by PHAs approved HUD, in... staff have certain levels of experience. DATES: Comments Due Date: October 27, 2010. ADDRESSES...

  18. Defense Acquisition Research Journal. Volume 19, Number 1, Issue 61, January 2012

    DTIC Science & Technology

    2012-01-01

    format (author-date-page number form of citation) as outlined in the Publication Manual of the American Psycho- logical Association ( 6th Edition ). For all...other style questions, please refer to the Chicago Manual of Style (15th Edition ). Contributors are encouraged to seek the advice of a reference...theme editions . Please consult the DAU home page for current themes being solicited. See print schedule below. 2012 Due Date Publication Date July 1

  19. Searching for missing heritability: Designing rare variant association studies

    PubMed Central

    Zuk, Or; Schaffner, Stephen F.; Samocha, Kaitlin; Do, Ron; Hechter, Eliana; Kathiresan, Sekar; Daly, Mark J.; Neale, Benjamin M.; Sunyaev, Shamil R.; Lander, Eric S.

    2014-01-01

    Genetic studies have revealed thousands of loci predisposing to hundreds of human diseases and traits, revealing important biological pathways and defining novel therapeutic hypotheses. However, the genes discovered to date typically explain less than half of the apparent heritability. Because efforts have largely focused on common genetic variants, one hypothesis is that much of the missing heritability is due to rare genetic variants. Studies of common variants are typically referred to as genomewide association studies, whereas studies of rare variants are often simply called sequencing studies. Because they are actually closely related, we use the terms common variant association study (CVAS) and rare variant association study (RVAS). In this paper, we outline the similarities and differences between RVAS and CVAS and describe a conceptual framework for the design of RVAS. We apply the framework to address key questions about the sample sizes needed to detect association, the relative merits of testing disruptive alleles vs. missense alleles, frequency thresholds for filtering alleles, the value of predictors of the functional impact of missense alleles, the potential utility of isolated populations, the value of gene-set analysis, and the utility of de novo mutations. The optimal design depends critically on the selection coefficient against deleterious alleles and thus varies across genes. The analysis shows that common variant and rare variant studies require similarly large sample collections. In particular, a well-powered RVAS should involve discovery sets with at least 25,000 cases, together with a substantial replication set. PMID:24443550

  20. Frailty and sarcopenia: The potential role of an aged immune system.

    PubMed

    Wilson, Daisy; Jackson, Thomas; Sapey, Elizabeth; Lord, Janet M

    2017-07-01

    Frailty is a common negative consequence of ageing. Sarcopenia, the syndrome of loss of muscle mass, quality and strength, is more common in older adults and has been considered a precursor syndrome or the physical manifestation of frailty. The pathophysiology of both syndromes is incompletely described with multiple causes, inter-relationships and complex pathways proposed. Age-associated changes to the immune system (both immunesenescence, the decline in immune function with ageing, and inflammageing, a state of chronic inflammation) have been suggested as contributors to sarcopenia and frailty but a direct causative role remains to be established. Frailty, sarcopenia and immunesenescence are commonly described in older adults but are not ubiquitous to ageing. There is evidence that all three conditions are reversible and all three appear to share common inflammatory drivers. It is unclear whether frailty, sarcopenia and immunesenescence are separate entities that co-occur due to coincidental or potentially confounding factors, or whether they are more intimately linked by the same underlying cellular mechanisms. This review explores these possibilities focusing on innate immunity, and in particular associations with neutrophil dysfunction, inflammation and known mechanisms described to date. Furthermore, we consider whether the age-related decline in immune cell function (such as neutrophil migration), increased inflammation and the dysregulation of the phosphoinositide 3-kinase (PI3K)-Akt pathway in neutrophils could contribute pathogenically to sarcopenia and frailty. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  1. Comparing Characteristics of Highly Circulated Titles for Demand-Driven Collection Development.

    ERIC Educational Resources Information Center

    Britten, William A; Webster, Judith D.

    1992-01-01

    Describes methodology for analyzing MARC (machine-readable cataloging) records of highly circulating titles to document common characteristics for collection development purposes. Application of the methodology in a university library is discussed, and data are presented on commonality of subject heading, author, language, and imprint date for…

  2. Compositional and sensory characteristics of three native sun-dried date (Phoenix dactylifera L.) varieties grown in Oman.

    PubMed

    Al-Farsi, Mohamed; Alasalvar, Cesarettin; Morris, Anne; Baron, Mark; Shahidi, Fereidoon

    2005-09-21

    Three native sun-dried date varieties grown in Oman, namely, Fard, Khasab, and Khalas, were examined for their proximate composition, sugars, dietary fiber, minerals, and organic acids as well as sensory characteristics. The study was conducted on sun-dried dates due to their higher consumption compared with fresh dates. All results are expressed as mean value +/- standard deveiation (n = 3) on a fresh weight basis except for sensory analysis. Date varieties were found to be low in fat and protein, but rich in sugars, dietary fiber, and minerals. They were found to be a good source of energy (278-301 kcal/100 g), due to the high sugar content. Total sugar content ranged from 56.1 to 62.2 g/100 g, being lowest in Khasab and highest in Khalas. Total dietary fiber content of dates varied from 6.26 to 8.44 g/100 g, of which 84-94% was insoluble fiber. Twelve minerals were studied in dates, among which the major minerals were potassium, calcium, magnesium, and phosphorus. Date varieties were also found to be an excellent source of selenium (ranging from 0.36 to 0.53 mg/100 g). Six organic acids were positively identified, among which malic acid predominated in all varieties. Differences (p < 0.05) in the contents of dietary fiber, organic acids, and certain minerals were observed among the three date varieties examined. Descriptive sensory analysis showed that among the nine sensory attributes studied, only the attributes color and desirability were rated as being of significantly (p < 0.01) higher intensity in Fard than in Khasab, whereas flesh firmness was lower (p < 0.01). Thus, these results suggest that although all three dates serve as a good source of vital nutrients, the Khalas variety, which is considered as premium quality, had significantly higher contents of sugar and selenium and a significantly higher energy value than the other varieties studied.

  3. Sharing Rare Attitudes Attracts.

    PubMed

    Alves, Hans

    2018-04-01

    People like others who share their attitudes. Online dating platforms as well as other social media platforms regularly rely on the social bonding power of their users' shared attitudes. However, little is known about moderating variables. In the present work, I argue that sharing rare compared with sharing common attitudes should evoke stronger interpersonal attraction among people. In five studies, I tested this prediction for the case of shared interests from different domains. I found converging evidence that people's rare compared with their common interests are especially potent to elicit interpersonal attraction. I discuss the current framework's theoretical implications for impression formation and impression management as well as its practical implications for improving online dating services.

  4. Tafenoquine and its potential in the treatment and relapse prevention of Plasmodium vivax malaria: the evidence to date

    PubMed Central

    Ebstie, Yehenew A; Abay, Solomon M; Tadesse, Wondmagegn T; Ejigu, Dawit A

    2016-01-01

    Despite declining global malaria incidence, the disease continues to be a threat to people living in endemic regions. In 2015, an estimated 214 million new malaria cases and 438,000 deaths due to malaria were recorded. Plasmodium vivax is the second most common cause of malaria next to Plasmodium falciparum. Vivax malaria is prevalent especially in Southeast Asia and the Horn of Africa, with enormous challenges in controlling the disease. Some of the challenges faced by vivax malaria-endemic countries include limited access to effective drugs treating liver stages of the parasite (schizonts and hypnozoites), emergence/spread of drug resistance, and misperception of vivax malaria as nonlethal. Primaquine, the only 8-aminoquinoline derivative approved by the US Food and Drug Administration, is intended to clear intrahepatic hypnozoites of P. vivax (radical cure). However, poor adherence to a prolonged treatment course, drug-induced hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency, and the emergence of resistance make it imperative to look for alternative drugs. Therefore, this review focuses on data accrued to date on tafenoquine and gives insight on the potential role of the drug in preventing relapse and radical cure of patients with vivax malaria. PMID:27528800

  5. Maintenance Downtime

    Atmospheric Science Data Center

    2013-07-10

    ... will be unavailable March 5, 2013 8:00 am to 5:00 pm due to database maintenance. Date(s):  Tuesday, March 5, 2013 ... will be unavailable March 5, 2013 8:00 am to 5:00 pm due to database maintenance. ...

  6. Communicating/Muting Date Rape: A Co-Cultural Theoretical Analysis of Communication Factors Related to Rape Culture on a College Campus

    ERIC Educational Resources Information Center

    Burnett, Ann; Mattern, Jody L.; Herakova, Liliana L.; Kahl, David H., Jr.; Tobola, Cloy; Bornsen, Susan E.

    2009-01-01

    Previous studies suggest that college campuses foster a rape culture in which date rape (most commonly, rape of women) is an accepted part of campus activity (Buchwald, Fletcher, & Roth, 1993; Sanday, 2007). In focus groups at a Midwestern university, researchers asked students about rape as they experienced it or knew about it on campus. The…

  7. Drought-caused delay in nesting of Sonoran Desert birds and its facilitation of parasite- and predator-mediated variation in reproductive success

    USGS Publications Warehouse

    McCreedy, Chris; van Riper, Charles

    2015-01-01

    As our understanding of climate change has increased, so has our awareness of the impacts of these changes on biotic systems. Climate models are nearly unanimous in their predictions for increased drought frequency in southwestern North America, and delays in nest initiation due to drought may influence nesting success and productivity for many Sonoran Desert bird species. In southeastern California and western Arizona in 2004–2009, we found negative correlations for 13 of 13 species between nest initiation date and rainfall accumulation during the preceding 4-month winter rainy season. Nesting was delayed more than 3 weeks for some species during extreme droughts in 2006 and 2007. During 2004–2009, we found a significant negative effect of nest initiation date on nest survival probability (β̂ = −0.031 ± 0.005 SE, P < 0.001) for the four species of greatest sample size. To investigate the role of nesting delay in nesting success and productivity, in 2010 we conducted a manipulative experiment with Black-tailed Gnatcatchers (Polioptila melanura; BTGN) and Verdins (Auriparus flaviceps; VERD). Following a wet winter, we delayed clutch initiation dates for treatment pairs to match first-egg dates that we observed during droughts in 2006 and 2007. Nest initiation date had a significant negative effect on nest survival of both species (BTGN: β̂ = −1.18 ± 0.27 SE, P < 0.001; VERD: β̂ = −2.33 ± 0.51 SE, P = 0.003). Treatment pairs were unable to overcome the lost period of high productivity in March and early April, and had lower productivity than control pairs over the entire breeding season. As nest predation and Brown-headed Cowbird (Molothrus ater) parasitism were the most common causes of nest failure, we conclude that the impacts of climate change–caused drought on annual reproductive output in the Sonoran Desert will be further compounded by parasitism and predation for Black-tailed Gnatcatchers and by predation for Verdins.

  8. Biogeographic Dating of Speciation Times Using Paleogeographically Informed Processes

    PubMed Central

    Landis, Michael J.

    2017-01-01

    Abstract Standard models of molecular evolution cannot estimate absolute speciation times alone, and require external calibrations to do so, such as fossils. Because fossil calibration methods rely on the incomplete fossil record, a great number of nodes in the tree of life cannot be dated precisely. However, many major paleogeographical events are dated, and since biogeographic processes depend on paleogeographical conditions, biogeographic dating may be used as an alternative or complementary method to fossil dating. I demonstrate how a time-stratified biogeographic stochastic process may be used to estimate absolute divergence times by conditioning on dated paleogeographical events. Informed by the current paleogeographical literature, I construct an empirical dispersal graph using 25 areas and 26 epochs for the past 540 Ma of Earth’s history. Simulations indicate biogeographic dating performs well so long as paleogeography imposes constraint on biogeographic character evolution. To gauge whether biogeographic dating may be of practical use, I analyzed the well-studied turtle clade (Testudines) to assess how well biogeographic dating fares when compared to fossil-calibrated dating estimates reported in the literature. Fossil-free biogeographic dating estimated the age of the most recent common ancestor of extant turtles to be from the Late Triassic, which is consistent with fossil-based estimates. Dating precision improves further when including a root node fossil calibration. The described model, paleogeographical dispersal graph, and analysis scripts are available for use with RevBayes. PMID:27155009

  9. Production of functional pita bread using date seed powder.

    PubMed

    Platat, Carine; Habib, Hosam M; Hashim, Isameldin Bashir; Kamal, Hina; AlMaqbali, Fatima; Souka, Usama; Ibrahim, Wissam H

    2015-10-01

    Functional foods represent a novel approach to prevent diet-related diseases. Due to its excellent nutritional and antioxidant properties, date seed was used to develop functional pita bread. Flour was replaced by 5, 10, 15 and 20 % date seed powder. Regular and whole wheat pita breads were the references. Results clearly showed that date seed powder containing bread contained comparable dietary fibers levels as in whole wheat bread and higher levels of flavonoids and phenolics. Date seed powder containing breads were particularly rich in flavan-3-ols whereas reference breads did not contain any of them and only a limited amount of other phenolic compounds. They also exhibited a much higher antioxidant capacity. Additionally, compared to regular bread, acrylamide level was significantly lower in 5 % date seed powder containing bread, and lower in all date seed powder containing breads compared to whole wheat bread. Date seed powder supplemented bread appears as a promising functional ingredient to prevent chronic diseases.

  10. Double the dates and go for Bayes - Impacts of model choice, dating density and quality on chronologies

    NASA Astrophysics Data System (ADS)

    Blaauw, Maarten; Christen, J. Andrés; Bennett, K. D.; Reimer, Paula J.

    2018-05-01

    Reliable chronologies are essential for most Quaternary studies, but little is known about how age-depth model choice, as well as dating density and quality, affect the precision and accuracy of chronologies. A meta-analysis suggests that most existing late-Quaternary studies contain fewer than one date per millennium, and provide millennial-scale precision at best. We use existing and simulated sediment cores to estimate what dating density and quality are required to obtain accurate chronologies at a desired precision. For many sites, a doubling in dating density would significantly improve chronologies and thus their value for reconstructing and interpreting past environmental changes. Commonly used classical age-depth models stop becoming more precise after a minimum dating density is reached, but the precision of Bayesian age-depth models which take advantage of chronological ordering continues to improve with more dates. Our simulations show that classical age-depth models severely underestimate uncertainty and are inaccurate at low dating densities, and also perform poorly at high dating densities. On the other hand, Bayesian age-depth models provide more realistic precision estimates, including at low to average dating densities, and are much more robust against dating scatter and outliers. Indeed, Bayesian age-depth models outperform classical ones at all tested dating densities, qualities and time-scales. We recommend that chronologies should be produced using Bayesian age-depth models taking into account chronological ordering and based on a minimum of 2 dates per millennium.

  11. Studying and Dating Indian Ocean Tsunamis by Using Benthic Foraminifera in the Sediment Stratigraphy of South Andaman Islands, India

    NASA Astrophysics Data System (ADS)

    Johnson, F. C.

    2015-12-01

    We analyzed the foraminifera and dated them to identify the sea level fluctuations in the coastal sediment stratigraphy of Andaman Islands. Our recent paleotsunami investigations are specially focused on unusual large magnitude earthquake and tsunamis in the south coast of Andaman. Our detailed study on the foraminifers preserved in the near sub surface stratigraphy and AMS ages show a strong signature of the tsunami event very much similar to the modern tsunami of December 2004. We found that foraminifer is an ideal geological key to bracket paleotsunami events. The AMS ages of these foraminifers supports the ages given by corals of Sumatra with a small error bar. The recent research approach to identify the ruptures and tsunami based on the corals of south Sumatra suggests a large time span of 1000 years for such mega events. Our foraminiferal archives obtained from 10g soil samples from the 2.5m deep Holocene stratigraphy suggests four seismic predecessors similar to the 2004 event with ~Mw9 with huge rupture. Huge foraminiferal population in the sedimentary stratigraphy is an indicative of sea level changes and the signatures of abrasion in the foraminifer's test (180µm) indicate strong wave surges and bead load transport during tsunami events. Spontaneous death of organisms due to tsunami waves gives an exact time frame with a narrow age limit than the charcoal. Sediment stratigraphy of south Andaman had such changes in each millennium. Sediment stratigraphy sections shows the huge population and assemblages and the AMS dates of this foraminifera in south Andaman shows four mega events. This kind of fossil assemblages are commonly associated with the sea regression and transgressions in the geological time scale. Tamil 'Sangam literatures' one of the oldest literature available in Indian main land and the corals ages from Sumatra are also emphasizes the predecessors of such unusual large magnitude earthquakes and tsunamis in the Indian Ocean. All these signatures are indicators of sea level fluctuations associated with tsunamis due to large magnitude Earthquakes (~Mw9).

  12. The best marker for guiding the clinical management of patients with raised intracranial pressure-the RAP index or the mean pulse amplitude?

    PubMed

    Hall, Allan; O'Kane, Roddy

    2016-10-01

    Raised intracranial pressure is a common problem in a variety of neurosurgical conditions including traumatic brain injury, hydrocephalus and intracranial haemorrhage. The clinical management of these patients is guided by a variety of haemodynamic, biochemical and clinical factors. However to date there is no single parameter that is used to guide clinical management of patients with raised intracranial pressure (ICP). However, the role of ICP indices, specifically the mean pulse amplitude (AMP) and RAP index [correlation coefficient (R) between AMP amplitude (A) and mean ICP pressure (P); index of compensatory reserve], as an indicator of true ICP has been investigated. Whilst the RAP index has been used both as a descriptor of neurological deterioration in TBI patients and as a way of characterising the compensatory reserve in hydrocephalus, more recent studies have highlighted the limitation of the RAP index due to the influence that baseline effect errors have on the mean ICP, which is used in the calculation of the RAP index. These studies have suggested that the ICP mean pulse amplitude may be a more accurate marker of true intracranial pressure due to the fact that it is uninfluenced by the mean ICP and, therefore, the AMP may be a more reliable marker than the RAP index for guiding the clinical management of patients with raised ICP. Although further investigation needs to be undertaken in order to fully assess the role of ICP indices in guiding the clinical management of patients with raised ICP, the studies undertaken to date provide an insight into the potential role of ICP indices to treat raised ICP proactively rather than reactively and therefore help prevent or minimise secondary brain injury.

  13. Time since death and decay rate constants of Norway spruce and European larch deadwood in subalpine forests determined using dendrochronology and radiocarbon dating

    NASA Astrophysics Data System (ADS)

    Petrillo, M.; Cherubini, P.; Fravolini, G.; Ascher, J.; Schärer, M.; Synal, H.-A.; Bertoldi, D.; Camin, F.; Larcher, R.; Egli, M.

    2015-09-01

    Due to the large size and highly heterogeneous spatial distribution of deadwood, the time scales involved in the coarse woody debris (CWD) decay of Picea abies (L.) Karst. and Larix decidua Mill. in Alpine forests have been poorly investigated and are largely unknown. We investigated the CWD decay dynamics in an Alpine valley in Italy using the five-decay class system commonly employed for forest surveys, based on a macromorphological and visual assessment. For the decay classes 1 to 3, most of the dendrochronological samples were cross-dated to assess the time that had elapsed since tree death, but for decay classes 4 and 5 (poorly preserved tree rings) and some others not having enough tree rings, radiocarbon dating was used. In addition, density, cellulose and lignin data were measured for the dated CWD. The decay rate constants for spruce and larch were estimated on the basis of the density loss using a single negative exponential model. In the decay classes 1 to 3, the ages of the CWD were similar varying between 1 and 54 years for spruce and 3 and 40 years for larch with no significant differences between the classes; classes 1-3 are therefore not indicative for deadwood age. We found, however, distinct tree species-specific differences in decay classes 4 and 5, with larch CWD reaching an average age of 210 years in class 5 and spruce only 77 years. The mean CWD rate constants were 0.012 to 0.018 yr-1 for spruce and 0.005 to 0.012 yr-1 for larch. Cellulose and lignin time trends half-lives (using a multiple-exponential model) could be derived on the basis of the ages of the CWD. The half-lives for cellulose were 21 yr for spruce and 50 yr for larch. The half-life of lignin is considerably higher and may be more than 100 years in larch CWD.

  14. Unraveling the Alteration History of Serpentinites and Associated Ultramafic Rocks from the Kampos HPLT Subduction Complex, Syros, Greece

    NASA Astrophysics Data System (ADS)

    Cooperdock, E. H. G.; Stockli, D. F.

    2016-12-01

    Serpentinization, hydration of peridotite, has a profound effect on fundamental tectonic and petrologic processes such as deformation of the lithosphere, bulk rheology, fluid-mobile element cycling and deep earth carbon cycling. Though numerous studies have investigated the petrology, structure and geochemistry of serpentinites, the absolute chronology of serpentinization remains elusive due to a lack of accessory minerals that can be dated using established geochronological techniques. Magnetite forms as a common secondary mineral in serpentinites from the fluid-induced breakdown reaction of primary peridotite minerals. Magnetite (U-Th)/He chronometry provides the potential to directly date the cooling of exhumed ultramafic bodies and the low-temperature fluid alteration of serpentinites. We present the first application of magnetite (U-Th)/He chronometry to date stages of alteration in ultramafic rocks from the Kampos mélange belt, a high-pressure low-temperature (HP-LT) subduction complex that experienced exhumation in the Miocene on the island of Syros, Greece. Two generations of magnetite are distinguishable by grain size, magnetite trace element geochemistry and (U-Th)/He age. Large magnetite grains (mm) from a chlorite schist and a serpentinite schist have distinct geochemical signatures indicative of formation during blackwall-related fluid alteration and record Mid-Miocene exhumation-related cooling ages, similar to zircon (U-Th)/He ages from northern Syros. Smaller grains (µm) from the serpentinite schist lack blackwall-related fluid signatures and record post-exhumation mineral formation associated with widespread high-angle Pliocene normal faulting. These results reveal evidence for multiple episodes of fluid-rock alteration, which has implications for the cooling history and local geochemical exchanges of this HP-LT terrane. Given the fundamental impact of serpentinizaton on a vast array of tectonic, petrological, and geochemical processes, the ability to differentiate and date these alteration events can be used to address significant questions related to serpentinization in exhumed subduction complexes, continental margins, or obducted ophiolites.

  15. Acoustical detection of early instar Rhynchophorus ferrugineus (Coleoptera: Curculionidae) in Canary Island date palm Phoenix canariensis (Arecales: Arecaceae)

    USDA-ARS?s Scientific Manuscript database

    The red palm weevil (RPW), Rhynchophorus ferrugineus (Olivier), is of international concern due to destructive larval feeding within palm trees. Originating from tropical Asia, RPW has spread throughout the eastern hemisphere where it has become a significant economic pest to the ornamental and date...

  16. 78 FR 40135 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... effective 6/1/2013. Filed Date: 6/20/13. Accession Number: 20130620-5139. Comments Due: 5 p.m. ET 7/11/13... Electric Power Cooperative, Inc. NITSA and NOA to be effective 6/1/2013. Filed Date: 6/21/13. Accession...

  17. 77 FR 48511 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... effective 9/1/2012. Filed Date: 8/6/12. Accession Number: 20120806-5135. Comments Due: 5 p.m. ET 8/27/12...: EAI Marketing Agreement Refile to be effective 10/1/ 2012. Filed Date: 8/6/12. Accession Number...

  18. 78 FR 73854 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-09

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... effective 1/24/2014. Filed Date: 11/25/13. Accession Number: 20131125-5196. Comments Due: 5 p.m. ET 12/16/13... Generator, SA No. 2036 to be effective 11/1/2013. Filed Date: 11/26/13. Accession Number: 20131126-5125...

  19. 78 FR 69406 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-19

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... Marketplace. Filed Date: 11/1/13. Accession Number: 20131101-5148. Comments Due: 5 p.m. ET 11/22/13. Docket..., Springfield, MO NITSA and NOA Notice of Cancell to be effective 10/1/2013. Filed Date: 11/7/13. Accession...

  20. 78 FR 5435 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... CCI Roseton LLC. Filed Date: 1/16/13. Accession Number: 20130116-5132. Comments Due: 5 p.m. ET 2/6/13... Status of NRG Power Marketing LLC, et al. Filed Date: 1/14/13. Accession Number: 20130114-5241. Comments...

  1. 78 FR 15361 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-11

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... Regarding Operational Penalties for 2012. Filed Date: 3/1/13. Accession Number: 20130301-5102. Comments Due.... Description: 2013-02-28 SA 2507 Interstate-ITC E&P Agreement to be effective 3/1/2013. Filed Date: 2/28/13...

  2. 75 FR 44006 - Notice of Submission of Proposed Information Collection to OMB, HUD-Owned Real Estate-Sales...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ... Proposed Information Collection to OMB, HUD-Owned Real Estate--Sales Contracts and Addenda (HUD Programs... sales contracts and addenda in conjunction with offers to purchase HUD-owned property. The sales... paint hazards in HUD sales of pre-1978 construction. DATES: Comments Due Date: August 26, 2010...

  3. 40 CFR 63.152 - General reporting and continuous records.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... submitted semiannually no later than 60 calendar days after the end of each 6-month period. The first report... and shall cover the 6-month period beginning on the date the Notification of Compliance Status is due... quarterly. The first semiannual period is the 6-month period starting the date the Notification of...

  4. 40 CFR 63.152 - General reporting and continuous records.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... submitted semiannually no later than 60 calendar days after the end of each 6-month period. The first report... and shall cover the 6-month period beginning on the date the Notification of Compliance Status is due... quarterly. The first semiannual period is the 6-month period starting the date the Notification of...

  5. 40 CFR 63.152 - General reporting and continuous records.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... submitted semiannually no later than 60 calendar days after the end of each 6-month period. The first report... and shall cover the 6-month period beginning on the date the Notification of Compliance Status is due... quarterly. The first semiannual period is the 6-month period starting the date the Notification of...

  6. 40 CFR 63.152 - General reporting and continuous records.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... submitted semiannually no later than 60 calendar days after the end of each 6-month period. The first report... and shall cover the 6-month period beginning on the date the Notification of Compliance Status is due... quarterly. The first semiannual period is the 6-month period starting the date the Notification of...

  7. 40 CFR 63.152 - General reporting and continuous records.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... submitted semiannually no later than 60 calendar days after the end of each 6-month period. The first report... and shall cover the 6-month period beginning on the date the Notification of Compliance Status is due... quarterly. The first semiannual period is the 6-month period starting the date the Notification of...

  8. 7 CFR 762.124 - Interest rates, terms, charges, and fees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... economic reverses. (2) The final maturity date for each loan cannot exceed 7 years from the date of the... farm, or recover from a disaster or an economical reversal. (2) Loans with balloon installments must... payment comes due based on the expected financial condition of the operation, the depreciated value of the...

  9. 7 CFR 762.124 - Interest rates, terms, charges, and fees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... economic reverses. (2) The final maturity date for each loan cannot exceed 7 years from the date of the... farm, or recover from a disaster or an economical reversal. (2) Loans with balloon installments must... payment comes due based on the expected financial condition of the operation, the depreciated value of the...

  10. 7 CFR 762.124 - Interest rates, terms, charges, and fees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... economic reverses. (2) The final maturity date for each loan cannot exceed 7 years from the date of the... farm, or recover from a disaster or an economical reversal. (2) Loans with balloon installments must... payment comes due based on the expected financial condition of the operation, the depreciated value of the...

  11. 77 FR 33206 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ... Reliability Standard CIP- 006--Cyber Security--Physical Security of Critical Cyber Assets. Filed Date: 5/23/12... Company, LLC. Description: Certificate of Concurrence to be effective 7/12/2012. Filed Date: 5/24/12.... Comments Due: 5 p.m. ET 6/14/12. Docket Numbers: ER12-1845-000. Applicants: AEP Texas North Company...

  12. 75 FR 21017 - Notice of Proposed Information Collection for Public Comment: Notice of Funding Availability for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-22

    ... Research Grant Program AGENCY: Office of the Assistant Secretary for Public Development and Research, HUD... Act. The Department is soliciting public comments on the subject proposal. DATES: Comment Due Date: June 21, 2010. ADDRESSES: Interested persons are invited to submit comments regarding this proposal...

  13. 78 FR 8508 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ..., Inc. for an order pursuant to Section 203 of the Federal Power Act. Filed Date: 1/18/13 Accession... Applicants: Lea Power Partners, LLC, Waterside Power, LLC Description: Notice of change in status of Lea Power Partners, LLC, et al. Filed Date: 1/18/13 Accession Number: 20130118-5260 Comments Due: 5 p.m. ET...

  14. 13 CFR 120.465 - Civil penalty for late submission of required reports.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... must submit complete reports by the due dates described in the regulations or as directed in writing by... SBA Supervised Lender in writing of the amount of civil penalties imposed either upon receiving the... amount to SBA within 30 days of the date of SBA's written demand. (d) Identification during examination...

  15. 13 CFR 120.465 - Civil penalty for late submission of required reports.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... must submit complete reports by the due dates described in the regulations or as directed in writing by... SBA Supervised Lender in writing of the amount of civil penalties imposed either upon receiving the... amount to SBA within 30 days of the date of SBA's written demand. (d) Identification during examination...

  16. 13 CFR 120.465 - Civil penalty for late submission of required reports.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... must submit complete reports by the due dates described in the regulations or as directed in writing by... SBA Supervised Lender in writing of the amount of civil penalties imposed either upon receiving the... amount to SBA within 30 days of the date of SBA's written demand. (d) Identification during examination...

  17. 13 CFR 120.465 - Civil penalty for late submission of required reports.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... must submit complete reports by the due dates described in the regulations or as directed in writing by... SBA Supervised Lender in writing of the amount of civil penalties imposed either upon receiving the... amount to SBA within 30 days of the date of SBA's written demand. (d) Identification during examination...

  18. 78 FR 55091 - Fair Housing Initiatives Program-Fiscal Year 2013 Application and Award Policies and Procedures...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-09

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5733-N-01] Fair Housing Initiatives... for the Fair Housing Initiatives Program during Fiscal Year (FY) 2013. DATES: Comment Due Date... funding and grant administration under the Fair Housing Initiatives Program (FHIP), HUD invites comments...

  19. 77 FR 56197 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-12

    ... Transmission Northwest LLC. Description: Revising Creditworthiness Language to be effective 10/ 1/2012. Filed...-12 to be effective 10/1/2012. Filed Date: 8/31/12. Accession Number: 20120831-5051. Comments Due: 5 p.... Description: Fuel Filing on 8-31-12 to be effective 10/1/2012. Filed Date: 8/31/12. Accession Number: 20120831...

  20. 77 FR 62506 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ...), LLC. Filed Date: 8/20/12. Accession Number: 20120820-5043. Comments Due: 5 p.m. ET 10/24/12. Docket Numbers: ER12-1007-001. Applicants: AP Gas & Electric (NY), LLC. Description: Notification of Non-Material Change-in-Status of AP Gas & Electric (NY), LLC. Filed Date: 10/3/12. Accession Number: 20121003-5042...

  1. Supporting Success and Safety in Relationships. Autism at-a-Glance

    ERIC Educational Resources Information Center

    Szidon, K.; Hedges, S.

    2015-01-01

    Like other teens, many teens on the autism spectrum desire friendships and romantic partners. Due to challenges with social communication, some teens with Autism Spectrum Disorder (ASD) may have limited experience dating and could benefit from explicitly learning skills associated with successful and safe dating experiences. Teens with ASD may…

  2. 75 FR 79012 - Notice of Proposed Information Collection for Public Comment for the Family Unification Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... Information Collection for Public Comment for the Family Unification Program (FUP) AGENCY: Office of the Assistant Secretary for Public and Indian Housing, HUD. ACTION: Notice. SUMMARY: The proposed information... Department is soliciting public comments on the subject proposal. DATES: Comments Due Date: February 15, 2011...

  3. 76 FR 66315 - Notice of Proposed Information Collection for Public Comment for the Family Unification Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-26

    ... Information Collection for Public Comment for the Family Unification Program (FUP) AGENCY: Office of the Assistant Secretary for Public and Indian Housing, HUD. ACTION: Notice. SUMMARY: The proposed information... Department is soliciting public comments on the subject proposal. DATES: Comments Due Date: December 27, 2011...

  4. 48 CFR 33.208 - Interest on claims.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... otherwise would be due, if that date is later, until the date of payment. (b) Simple interest on claims... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Interest on claims. 33.208... REQUIREMENTS PROTESTS, DISPUTES, AND APPEALS Disputes and Appeals 33.208 Interest on claims. (a) The Government...

  5. 78 FR 77140 - Customs Brokers User Fee Payment for 2014

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-20

    ... Payment for 2014 AGENCY: U.S. Customs and Border Protection, Department of Homeland Security. ACTION..., association, or corporation, is due by February 21, 2014. U.S. Customs and Border Protection announces this date of payment for 2014 in accordance with the Tax Reform Act of 1986. DATES: Payment of the 2014...

  6. 38 CFR 9.5 - Payment of proceeds.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., discounted to the date of his or her death at the same rate used for inclusion of interest in the computation... remain unpaid will be discounted to the date of payment at the same rate used for inclusion of interest... is extended due to total disability converts the group insurance to an individual policy which is...

  7. 77 FR 10487 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... 203 of the Federal Power Act of American Electric Power Service Corporation. Filed Date: 2/10/12.../10/12. Accession Number: 20120210-5053. Comments Due: 5 p.m. ET 3/27/12. Docket Numbers: EC12-71-000... Power Act of American Electric Power Service Corporation. Filed Date: 2/10/12. Accession Number...

  8. 78 FR 67344 - Sunshine Act Meeting; New Time and Date of Proceeding

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... DEFENSE NUCLEAR FACILITIES SAFETY BOARD Sunshine Act Meeting; New Time and Date of Proceeding AGENCY: Defense Nuclear Facilities Safety Board. ACTION: Notice of Public Meeting and Hearing; New Time... the postponement in the Federal Register due to the shutdown. The Board has now decided on a new time...

  9. 75 FR 65643 - Notice of Proposed Information Collection for Public Comment: Survey of Market Absorption of New...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-26

    ... at [email protected] or to Robert R. Callis, U.S. Census Bureau, Social, Economic and Housing... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5382-N-16] Notice of Proposed... subject proposal. DATES: Comments Due Date: December 27, 2010. ADDRESSES: Interested persons are invited...

  10. 77 FR 13656 - Call for Papers: National Symposium on Moving Target Research

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ... of moving target. There will be an accompanying poster session open for researchers and companies... dates/time 18:00 EDT): Draft Papers due April 2, 2012 Notification April 20, 2012 Poster abstracts due...

  11. Stochastic scheduling on a repairable manufacturing system

    NASA Astrophysics Data System (ADS)

    Li, Wei; Cao, Jinhua

    1995-08-01

    In this paper, we consider some stochastic scheduling problems with a set of stochastic jobs on a manufacturing system with a single machine that is subject to multiple breakdowns and repairs. When the machine processing a job fails, the job processing must restart some time later when the machine is repaired. For this typical manufacturing system, we find the optimal policies that minimize the following objective functions: (1) the weighed sum of the completion times; (2) the weighed number of late jobs having constant due dates; (3) the weighted number of late jobs having random due dates exponentially distributed, which generalize some previous results.

  12. Longitudinal relationships between individual and class norms supporting dating violence and perpetration of dating violence.

    PubMed

    Taylor, Katherine A; Sullivan, Terri N; Farrell, Albert D

    2015-03-01

    Dating violence is commonly perpetrated in adolescence, making it imperative to understand risk factors in order to inform prevention efforts. Although individual norms supporting dating violence are strongly related to its perpetration, few studies have examined their longitudinal impact. Moreover, the influence of class norms (i.e., norms for students in the same grade, cohort, and school) supporting dating violence on perpetration has rarely been studied. The current study examined longitudinal relationships between individual and class norms supporting dating violence and perpetration of physical and psychological dating violence. Participants were two cohorts of sixth graders from 37 schools who were in dating relationships at Wave 1 and 6 months later at Wave 2 (N = 2,022; 43% female; 52% African American, 21% Latino/a, 20% White, and 7% other). The analyses used a multilevel approach, with students represented at Level 1 and classes (n = 74) at Level 2. The models tested direct effects of Wave 1 individual and class norms supporting dating violence on subsequent changes in perpetration of dating violence at Wave 2 and the extent to which gender moderated these relationships. The findings indicated that greater individual norms supporting male dating violence predicted greater change in perpetration of physical and psychological dating violence and greater individual norms supporting female dating violence predicted greater change in perpetration of psychological dating violence. Greater class norms supporting male dating violence predicted greater change in perpetration of physical dating violence; whereas greater class norms supporting female dating violence predicted less change in perpetration of physical dating violence. These findings highlight the need to address norms in early adolescence.

  13. Mold-Ripened Soft Cheeses Fortified with Date Palm Fruit Product as Functional Dairy Products.

    PubMed

    Al-Otaibi, Mutlag M; Haddadin, Jamal S; Haddadin, Malik S Y

    2016-01-01

    Date fruit based products are gaining popularity among the consumers in almost all date growing countries due to its added nutritional value. Therefore, novel products were developed by combining two types of foods i.e., soft ripened cheeses and date fruit syrups or date powder. This study is the first to report the surface mold-ripened cheese production with date syrup and date powder. Model cheeses were prepared from pasteurized milk inoculated with Streptococcus thermophilus, Penicillium camemberti and Geotrichum candidum. Date syrup-1, date syrup-2, date powder or the date mixture were added at the stage of curdling. Based on the kinetic growth of the microbial groups in all the treatments, there was no change in the growth of these in various date palm product. On the contrary It may be said that addition of the date fruit product supports their growth. After 35 days, the amounts of total poly phenols were 128.3 ± 1.01, 81.8 ± 1.11, 33.5 ± 2.19, 156.23 ± 1.27 mg GAE/100 g in the cheeses support with date syrup-1, date syrup-2, date powder or the date mixture, respectively. Antioxidant activity of date fruits ranged from 80.13 IC50 (date syrup-2) to 82.23 IC50 (date syrup-1). Based on the chemical characteristics and sensory analysis, the study results showed the potential for innovative application of date products for developing new functional dairy products as an ideal medium for the delivery of biological active compounds with beneficial health effects over.

  14. REAR VIEW OF THE HOUSE FROM ACROSS THE COMMON AREA ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    REAR VIEW OF THE HOUSE FROM ACROSS THE COMMON AREA WITH AN ADJACENT HOUSE VISIBLE ON THE RIGHT - Camp H.M. Smith and Navy Public Works Center Manana Title VII (Capehart) Housing, Three-Bedroom Single-Family Type 7, Birch Circle, Elm Drive, Elm Circle, and Date Drive, Pearl City, Honolulu County, HI

  15. Unidimensional and Multidimensional Models for Item Response Theory.

    ERIC Educational Resources Information Center

    McDonald, Roderick P.

    This paper provides an up-to-date review of the relationship between item response theory (IRT) and (nonlinear) common factor theory and draws out of this relationship some implications for current and future research in IRT. Nonlinear common factor analysis yields a natural embodiment of the weak principle of local independence in appropriate…

  16. Engaging Educators: Common Core State Standards Implementation

    ERIC Educational Resources Information Center

    Achieve, Inc., 2011

    2011-01-01

    To date, 44 states and the District of Columbia have adopted the Common Core State Standards (CCSS). Achieve has prepared this planning document to help all states in the American Diploma Project Network (ADP) and the Partnership for Assessment of Readiness for College and Careers (PARCC) consortium engage educators in the essential work of…

  17. Soft Tissue Phantoms for Realistic Needle Insertion: A Comparative Study.

    PubMed

    Leibinger, Alexander; Forte, Antonio E; Tan, Zhengchu; Oldfield, Matthew J; Beyrau, Frank; Dini, Daniele; Rodriguez Y Baena, Ferdinando

    2016-08-01

    Phantoms are common substitutes for soft tissues in biomechanical research and are usually tuned to match tissue properties using standard testing protocols at small strains. However, the response due to complex tool-tissue interactions can differ depending on the phantom and no comprehensive comparative study has been published to date, which could aid researchers to select suitable materials. In this work, gelatin, a common phantom in literature, and a composite hydrogel developed at Imperial College, were matched for mechanical stiffness to porcine brain, and the interactions during needle insertions within them were analyzed. Specifically, we examined insertion forces for brain and the phantoms; we also measured displacements and strains within the phantoms via a laser-based image correlation technique in combination with fluorescent beads. It is shown that the insertion forces for gelatin and brain agree closely, but that the composite hydrogel better mimics the viscous nature of soft tissue. Both materials match different characteristics of brain, but neither of them is a perfect substitute. Thus, when selecting a phantom material, both the soft tissue properties and the complex tool-tissue interactions arising during tissue manipulation should be taken into consideration. These conclusions are presented in tabular form to aid future selection.

  18. University of Washington Clinical Neutron Facility: Report on 26 Years of Operation

    NASA Astrophysics Data System (ADS)

    Laramore, George E.; Emery, Robert; Reid, David; Banerian, Stefani; Kalet, Ira; Jacky, Jonathan; Risler, Ruedi

    2011-12-01

    Particle radiotherapy facilities are highly capital intensive and must operate over decades to recoup the original investment. We describe the successful, long-term operation of a neutron radiotherapy center at the University of Washington, which has been operating continuously since September 1984. To date, 2836 patients have received neutron radiotherapy. The mission of the facility has also evolved to include the production of unique radioisotopes that cannot be made with the low-energy cyclotrons more commonly found in nuclear medicine departments. The facility is also used for neutron damage testing for industrial devices. In this paper, we describe the challenges of operating such a facility over an extended time period, including a planned maintenance and upgrade program serving diverse user groups, and summarize the major clinical results in terms of tumor control and normal tissue toxicity. Over time, the mix of patients being treated has shifted from common tumors such as prostate cancer, lung cancer, and squamous cell tumors of the head and neck to the rarer tumors such as salivary gland tumors and sarcomas due to the results of clinical trials. Current indications for neutron radiotherapy are described and neutron tolerance doses for a range of normal tissues presented.

  19. Classification of Sporting Activities Using Smartphone Accelerometers

    PubMed Central

    Mitchell, Edmond; Monaghan, David; O'Connor, Noel E.

    2013-01-01

    In this paper we present a framework that allows for the automatic identification of sporting activities using commonly available smartphones. We extract discriminative informational features from smartphone accelerometers using the Discrete Wavelet Transform (DWT). Despite the poor quality of their accelerometers, smartphones were used as capture devices due to their prevalence in today's society. Successful classification on this basis potentially makes the technology accessible to both elite and non-elite athletes. Extracted features are used to train different categories of classifiers. No one classifier family has a reportable direct advantage in activity classification problems to date; thus we examine classifiers from each of the most widely used classifier families. We investigate three classification approaches; a commonly used SVM-based approach, an optimized classification model and a fusion of classifiers. We also investigate the effect of changing several of the DWT input parameters, including mother wavelets, window lengths and DWT decomposition levels. During the course of this work we created a challenging sports activity analysis dataset, comprised of soccer and field-hockey activities. The average maximum F-measure accuracy of 87% was achieved using a fusion of classifiers, which was 6% better than a single classifier model and 23% better than a standard SVM approach. PMID:23604031

  20. 34 CFR 682.507 - Due diligence in collecting a loan.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of this section, the borrower's delinquency begins on the day after the due date of an installment... knowledge, the delinquency begins 30 days after the day the lender receives notice that the borrower has... the due diligence procedures in § 682.411 in collecting a Federal GSL loan. (b) Initial delinquency...

  1. Vapor Intrusion Assessment and Mitigation 2012

    DTIC Science & Technology

    2012-03-26

    1 Geosyntec 0 consultants Vapor Intrusion Assessment and Mitigation 2012 Robert Ettinger, M.S., P.E., Todd McAiary, M.Sc., P.Eng., P.G...REPORT DATE 26 MAR 2012 2. REPORT TYPE 3. DATES COVERED 00-00-2012 to 00-00-2012 4. TITLE AND SUBTITLE Vapor Intrusion Assessment and...Updates • Typical Assessment Approaches and Common Challenges • Methods to Distinguish Background Sources (McHugh) • Significance • Compound

  2. Information Management: Army Information Management

    DTIC Science & Technology

    2002-05-31

    user’s Internet needs in one location. Portals commonly provide services such as e -mail, online chat forums, searching, content, newsfeeds and others. Web...The revision dated 31 May 2002-- o Includes new policy on Army knowledge management, Army Knowledge Online, e - mail, Web site management, the use of...Web portals , and Web site. o The revision dated 15 February 2000-- o Replaces the title ’The Army Information Resources Management Program’ with the

  3. Risks of all-cause and site-specific fractures among hospitalized patients with COPD

    PubMed Central

    Liao, Kuang-Ming; Liang, Fu-Wen; Li, Chung-Yi

    2016-01-01

    Abstract Patients with chronic obstructive pulmonary disease (COPD) have a high prevalence of osteoporosis. The clinical sequel of osteoporosis is fracture. Patients with COPD who experience a fracture also have increased morbidity and mortality. Currently, the types of all-cause and site-specific fracture among patients with COPD are unknown. Thus, we elucidated the all-cause and site-specific fractures among patients with COPD. A retrospective, population-based, cohort study was conducted utilizing the Taiwan Longitudinal Health Insurance Database. Patients with COPD were defined as those who were hospitalized with an International Classification of Diseases, Ninth Revision, Clinical Modification code of 490 to 492 or 496 between 2001 and 2011. The index date was set as the date of discharge. The study patients were followed from the index date to the date when they sought care for any type of fracture, date of death, date of health insurance policy termination, or the last day of 2013. The types of fracture analyzed in this study included vertebral, rib, humeral, radial and ulnar/wrist, pelvic, femoral, and tibial and fibular fractures. The cohort consisted of 11,312 patients with COPD. Among these patients, 1944 experienced fractures. The most common site-specific fractures were vertebral, femoral, rib, and forearm fractures (radius, ulna, and wrist) at 32.4%, 31%, 12%, and 11.8%, respectively. The adjusted hazard ratios of fracture were 1.71 [95% confidence interval (95% CI) = 1.56–1.87] for female patient with COPD and 1.50 (95% CI = 1.39–1.52) for patients with osteoporosis after covariate adjustment. Vertebral and hip fractures are common among patients with COPD, especially among males with COPD. Many comorbidities contribute to the high risk of fracture among patients with COPD. PMID:27749576

  4. Risks of all-cause and site-specific fractures among hospitalized patients with COPD.

    PubMed

    Liao, Kuang-Ming; Liang, Fu-Wen; Li, Chung-Yi

    2016-10-01

    Patients with chronic obstructive pulmonary disease (COPD) have a high prevalence of osteoporosis. The clinical sequel of osteoporosis is fracture. Patients with COPD who experience a fracture also have increased morbidity and mortality. Currently, the types of all-cause and site-specific fracture among patients with COPD are unknown. Thus, we elucidated the all-cause and site-specific fractures among patients with COPD.A retrospective, population-based, cohort study was conducted utilizing the Taiwan Longitudinal Health Insurance Database.Patients with COPD were defined as those who were hospitalized with an International Classification of Diseases, Ninth Revision, Clinical Modification code of 490 to 492 or 496 between 2001 and 2011. The index date was set as the date of discharge. The study patients were followed from the index date to the date when they sought care for any type of fracture, date of death, date of health insurance policy termination, or the last day of 2013. The types of fracture analyzed in this study included vertebral, rib, humeral, radial and ulnar/wrist, pelvic, femoral, and tibial and fibular fractures.The cohort consisted of 11,312 patients with COPD. Among these patients, 1944 experienced fractures. The most common site-specific fractures were vertebral, femoral, rib, and forearm fractures (radius, ulna, and wrist) at 32.4%, 31%, 12%, and 11.8%, respectively. The adjusted hazard ratios of fracture were 1.71 [95% confidence interval (95% CI) = 1.56-1.87] for female patient with COPD and 1.50 (95% CI = 1.39-1.52) for patients with osteoporosis after covariate adjustment.Vertebral and hip fractures are common among patients with COPD, especially among males with COPD. Many comorbidities contribute to the high risk of fracture among patients with COPD.

  5. Hybrid Metaheuristics for Solving a Fuzzy Single Batch-Processing Machine Scheduling Problem

    PubMed Central

    Molla-Alizadeh-Zavardehi, S.; Tavakkoli-Moghaddam, R.; Lotfi, F. Hosseinzadeh

    2014-01-01

    This paper deals with a problem of minimizing total weighted tardiness of jobs in a real-world single batch-processing machine (SBPM) scheduling in the presence of fuzzy due date. In this paper, first a fuzzy mixed integer linear programming model is developed. Then, due to the complexity of the problem, which is NP-hard, we design two hybrid metaheuristics called GA-VNS and VNS-SA applying the advantages of genetic algorithm (GA), variable neighborhood search (VNS), and simulated annealing (SA) frameworks. Besides, we propose three fuzzy earliest due date heuristics to solve the given problem. Through computational experiments with several random test problems, a robust calibration is applied on the parameters. Finally, computational results on different-scale test problems are presented to compare the proposed algorithms. PMID:24883359

  6. Amazon rain-forest fires.

    PubMed

    Sanford, R L; Saldarriaga, J; Clark, K E; Uhl, C; Herrera, R

    1985-01-04

    Charcoal is common in the soils of mature rain forests within 75 kilometers of San Carlos de Rio Negro in the north central Amazon Basin. Carbon-14 dates of soil charcoal from this region indicate that numerous fires have occurred since the mid-Holocene epoch. Charcoal is most common in tierra firme forest Oxisols and Ultisols and less common in caatinga and igapo forest soils. Climatic changes or human activities, or both, have caused rain-forest fires.

  7. A Pilot Study of Common Bile Duct Reconstruction with CorMatrix Extracellular Matrix in Swine (Sus scrofa)

    DTIC Science & Technology

    2015-02-06

    additional pages if necessary.) PROTOCOL#: FDG20140008A DATE: 6 February 2015 PROTOCOL TITLE: A Pilot Study of Common Bile Duct Reconstruction with...obstruction or bile peritonitis. This was reported to the IACUC chair. 9. REDUCTION, REFINEMENT, OR REPLACEMENT OF ANIMAL USE; REPLACEMENT...benefit the DoD/USAF? We developed a porcine model of common bile duct injury and interposition grafting, gained experience managing these patients

  8. Can Single Crystal (U-Th)/He Zircon Ages from Nördlinger Ries Suevite be Linked to Impact-Related Shock Effects?

    NASA Astrophysics Data System (ADS)

    van Soest, M. C.; Cooper, F. J.; Wartho, J.; Hodges, K.; Buchner, E.; Schmieder, M.; Koeberl, C.

    2010-12-01

    Dating of impact-related material is difficult especially when pristine impact melt is unavailable. In the absence of such melts, most geochronometers in shocked basement or melt-poor impact rocks yield only partially reset or non-reset ages. In such cases, application of the low closure temperature apatite and zircon (U-Th)/He geochronometers can be successful, since impact-related physical and thermal shock should reset the He systematics in both minerals in most materials affected by the impact. For a proof of concept study on the well-studied Ries impact structure, we (U-Th)/He dated apatites (14.08 ± 0.26 Ma 2σ, n = 5) and zircons (14.26 ± 0.31 Ma 2σ, n = 10) from two Aumühle quarry suevite samples and one Polsingen quarry impact melt rock, which was dated at 14.37 ± 0.30 Ma (2σ) using Ar-Ar stepwise heating of recrystallized K-feldspar melt (Buchner et al., 2010). The (U-Th)/He ages agree well with the 14.37 Ma age, but are slightly younger than the suggested age of 14.59 ± 0.20 Ma (2σ - based on recent, post 1995, Ar-Ar data, Buchner et al., 2010) for the impact structure. However, among the 27 zircons dated, 6 were partially reset (>16Ma), and 11 zircons yielded younger dates (<13.5 Ma).The younger dates are problematic for successful (U-Th)/He dating of impact structures of unknown age, as they would be identified incorrectly as the age of the impact event. The cause for these younger dates may be: a) partial He loss due to a post-impact thermal event, which at Ries is unlikely as there is no geological evidence for such an event; b) compromised He retention due to metamictization by progressive radiation damage; or c) compromised He retention due to impact shock-related effects. The latter two causes can produce similar visual effects on zircon and the He loss mechanism is also similar, i.e. changes in the zircon crystal structure on a micro scale. However, the effects of these processes on zircon have been documented extensively by non-destructive analytical methods such as Raman spectroscopy, single crystal XRD, and SEM. These techniques have provided a means to distinguish shock from radiation damage effects, based on the presence of the high pressure zircon polymorph reidite, at shock levels >20 GPa (Wittmann et al., 2006). In order to establish if these effects can be identified in individual zircons before undertaking (U-Th)/He dating, and thus if these analytical methods can be used to pre-select suitable zircons for dating, 30 Ries zircons have been picked, based on euhedral shape and size, from two suevite samples for non-destructive geochemical and crystal structure studies prior to (U-Th)/He dating. Initial results from Raman spectroscopy indicate reidite is present in >80% of the grains, providing clear evidence for shock, while other grains show extensive amorphization likely due to extreme shock or radiation damage. References: Buchner et al. (2010) MAPS 45, 5: 662-674; Wittman et al. (2006) MAPS 41, 3: 433-454.

  9. Dating Violence among High-Risk Young Women: A Systematic Review Using Quantitative and Qualitative Methods

    PubMed Central

    Joly, Lauren E.; Connolly, Jennifer

    2016-01-01

    Our systematic review identified 21 quantitative articles and eight qualitative articles addressing dating violence among high risk young women. The groups of high-risk young women in this review include street-involved, justice-involved, pregnant or parenting, involved with Child Protective Services, and youth diagnosed with a mental health issue. Our meta-analysis of the quantitative articles indicated that 34% (CI = 0.24–0.45) of high-risk young women report that they have been victims of physical dating violence and 45% (CI = 0.31–0.61) of these young women report perpetrating physical dating violence. Significant moderator variables included questionnaire and timeframe. Meta-synthesis of the qualitative studies revealed that high-risk young women report perpetrating dating violence to gain power and respect, whereas women report becoming victims of dating violence due to increased vulnerability. PMID:26840336

  10. Temperature, Sowing and Harvest Dates, and Yield of Maize in the Southwestern US

    NASA Astrophysics Data System (ADS)

    Kafatos, M.; Stack, D.; Myoung, B.; Kim, S. H.; Kim, J.

    2014-12-01

    Since sowing date of maize is sensitive to climate variability and changes, it is of a practical importance to examine how sowing dates affect maize yields in various temperature regimes in the southwestern US. A 21-year (1991-2011) simulation of maize yield using Agricultural Production Systems sIMulator (APSIM) with observed meteorological forcing, shows that earlier sowing dates are favorable for higher yields primarily by increasing the length of growing season in cold mountaineous regions. In these regions, warmer conditions in the sowing period tend to advance the sowing date and then enhance yield. Over low-elevation warm regions, yields are less correlated with sowing dates and the length of growing season, perhaps because growing season temperatures are high enough for fast growth. Instead, in the warm regions, maize yields are sensitive to temperature variations during the late growing season due to adverse effects of extreme high temperature events on maize development.

  11. Beyond assembly bias: exploring secondary halo biases for cluster-size haloes

    NASA Astrophysics Data System (ADS)

    Mao, Yao-Yuan; Zentner, Andrew R.; Wechsler, Risa H.

    2018-03-01

    Secondary halo bias, commonly known as `assembly bias', is the dependence of halo clustering on a halo property other than mass. This prediction of the Λ Cold Dark Matter cosmology is essential to modelling the galaxy distribution to high precision and interpreting clustering measurements. As the name suggests, different manifestations of secondary halo bias have been thought to originate from halo assembly histories. We show conclusively that this is incorrect for cluster-size haloes. We present an up-to-date summary of secondary halo biases of high-mass haloes due to various halo properties including concentration, spin, several proxies of assembly history, and subhalo properties. While concentration, spin, and the abundance and radial distribution of subhaloes exhibit significant secondary biases, properties that directly quantify halo assembly history do not. In fact, the entire assembly histories of haloes in pairs are nearly identical to those of isolated haloes. In general, a global correlation between two halo properties does not predict whether or not these two properties exhibit similar secondary biases. For example, assembly history and concentration (or subhalo abundance) are correlated for both paired and isolated haloes, but follow slightly different conditional distributions in these two cases. This results in a secondary halo bias due to concentration (or subhalo abundance), despite the lack of assembly bias in the strict sense for cluster-size haloes. Due to this complexity, caution must be exercised in using any one halo property as a proxy to study the secondary bias due to another property.

  12. UAIS Unruptured Aneurysms Italian Study (Dedicated to Massimo Collice).

    PubMed

    Maira, Giulio; Mannino, Stefano; D'Aliberti, Giuseppe; Albanese, Alessio; Sabatino, Giovanni; Delfini, Roberto; Tomasello, Francesco; Alafaci, Concetta; Marchese, Enrico

    2018-02-23

    Unruptured intracranial aneurysms (UIAs) are increasingly identified and are an important health-care burden; in the past they were commonly treated by surgical clipping, but nowadays endovascular coil embolization is increasingly employed as an alternative. The Unruptured Aneurysms Italian Study (UAIS) is a multicentric cooperative prospective study aimed to delineate the "State of the Art" of UIAs treatment in Italy. 51 Italian Neurosurgical and Neuroradiological Units, representatives of all 20 Italian regions are involved in the Study. UAIS started on June 2003 and ended on July 2007. 1138 patients were collected by that date, but 181 were ruled-out due to severe violation of the protocol; 957 had complete data and could be statistically evaluated. UAIS demonstrates that the treatment of UAs, as performed in Italy as a Nation, is effective in improving long-term outcome vs natural history, particularly in aneurysms larger than 7 mm.

  13. Selectively starving cancer cells through dietary manipulation: methods and clinical implications.

    PubMed

    Simone, Brittany A; Champ, Colin E; Rosenberg, Anne L; Berger, Adam C; Monti, Daniel A; Dicker, Adam P; Simone, Nicole L

    2013-07-01

    As the link between obesity and metabolic syndrome and cancer becomes clearer, the need to determine the optimal way to incorporate dietary manipulation in the treatment of cancer patients becomes increasingly important. Metabolic-based therapies, such as caloric restriction, intermittent fasting and a ketogenic diet, have the ability to decrease the incidence of spontaneous tumors and slow the growth of primary tumors, and may have an effect on distant metastases in animal models. Despite the abundance of preclinical data demonstrating the benefit of dietary modification for cancer, to date there are few clinical trials targeting diet as an intervention for cancer patients. We hypothesize that this may be due, in part, to the fact that several different types of diet modification exist with no clear recommendations regarding the optimal method. This article will delineate three commonly used methods of dietary manipulation to assess the potential of each as a regimen for cancer therapy.

  14. [Addison's disease].

    PubMed

    Quinkler, M

    2012-09-01

    The clinical signs and symptoms of primary adrenal insufficiency are unspecific often causing a delayed diagnosis or even misdiagnosis. In the diagnostic work-up the short synacthen test is regarded as the gold standard. Hydrocortisone and fludrocortisone are the preferred therapy for Addison's disease. The management and surveillance of therapy requires experience and several aspects need to be followed to prevent side effects which might occur due to overtreatment or undertreatment. Very important aspects in therapy are the repeated teaching of the patient and relatives, the issuing of an emergency steroid card and the prescription of a glucocorticoid emergency set. Acute adrenal failure (adrenal crisis), which might be the first manifestation of adrenal insufficiency, is a life-threatening situation requiring immediate glucocorticoid administration and fluid substitution. The most common causes for an adrenal crisis are gastrointestinal infections and fever and discontinuation of glucocorticoid therapy. This article gives an up-to-date overview of diagnostic and therapeutic aspects of Addison's disease.

  15. Chytrid fungus parasitizing the wild amphibian Leptodactylus ocellatus (Anura: Leptodactylidae) in Argentina.

    PubMed

    Herrera, Raúl A; Steciow, Mónica M; Natale, Guillermo S

    2005-05-20

    The present contribution is the first report of parasitosis by a chytrid fungus in wild anuran amphibians in Argentina, as well as the first case of amphibian mortality documented to date in Argentina. We report the presence of the chytrid fungus in dead adult Leptodactylus ocellatus. It has been suggested that chytridiomycosis is the main cause of death in several amphibian populations worldwide. Our study demonstrates that chytridiomycosis afflicts L. ocellatus, a common widespread amphibian species, and is the first report of chytridiomycosis in the Argentinian lowlands. The occurrence at this latitude would indicate an extended distribution of this fungus in wildlife populations. It is also the first report of amphibian mortality due to chytrid fungus in our country. It is noteworthy that the site of collection is situated very close to sea level in a temperate climate zone and that this represents the southern most record for South American wild amphibians.

  16. Complex Greenland outlet glacier flow captured

    PubMed Central

    Aschwanden, Andy; Fahnestock, Mark A.; Truffer, Martin

    2016-01-01

    The Greenland Ice Sheet is losing mass at an accelerating rate due to increased surface melt and flow acceleration in outlet glaciers. Quantifying future dynamic contributions to sea level requires accurate portrayal of outlet glaciers in ice sheet simulations, but to date poor knowledge of subglacial topography and limited model resolution have prevented reproduction of complex spatial patterns of outlet flow. Here we combine a high-resolution ice-sheet model coupled to uniformly applied models of subglacial hydrology and basal sliding, and a new subglacial topography data set to simulate the flow of the Greenland Ice Sheet. Flow patterns of many outlet glaciers are well captured, illustrating fundamental commonalities in outlet glacier flow and highlighting the importance of efforts to map subglacial topography. Success in reproducing present day flow patterns shows the potential for prognostic modelling of ice sheets without the need for spatially varying parameters with uncertain time evolution. PMID:26830316

  17. Fibroma of the vulva: a case report.

    PubMed

    Berlin, Melvin; Berlin, Scott

    2007-06-01

    It is rare to see large vulvar growths that are not trauma related in young women. The largest vulvar mass recorded dates back to 1851. Fibroma of the vulva is not common but, if not seen early and removed, can be emotionally draining for the patient. A large vulvar mass was found in an 18-year-old woman and was expeditiously excised. The patient was emotionally withdrawn and would not participate in any school or social activities. She would carry moist paper towels with her to prevent maceration of the lower abdomen and lesion wall. An extraordinary physical finding can embarrass and alter a patient's demeanor and should be addressed without delay. The emotional condition of our patient prior to surgery consisted of depression and emotional stress due to the large vulvar mass. Following surgery the patient was comfortable, and her demeanor is now excellent.

  18. Mechanical design of a low concentration ratio solar array for a space station application

    NASA Technical Reports Server (NTRS)

    Biss, M. S.; Hsu, L.

    1983-01-01

    This paper describes a preliminary study and conceptual design of a low concentration ratio solar array for a space station application with approximately a 100 kW power requirement. The baseline design calls for a multiple series of inverted, truncated, pyramidal optical elements with a geometric concentration ratio (GCR) of 6. It also calls for low life cycle cost, simple on-orbit maintainability, 1984 technology readiness date, and gallium arsenide (GaAs) of silicon (Si) solar cell interchangeability. Due to the large area needed to produce the amount of power required for the baseline space station, a symmetrical wing design, making maximum use of the commonality of parts approach, was taken. This paper will describe the mechanical and structural design of a mass-producible solar array that is very easy to tailor to the needs of the individual user requirement.

  19. Selenium nanoparticles inhibit Staphylococcus aureus growth

    PubMed Central

    Tran, Phong A; Webster, Thomas J

    2011-01-01

    Staphylococcus aureus is a key bacterium commonly found in numerous infections. S. aureus infections are difficult to treat due to their biofilm formation and documented antibiotic resistance. While selenium has been used for a wide range of applications including anticancer applications, the effects of selenium nanoparticles on microorganisms remain largely unknown to date. The objective of this in vitro study was thus to examine the growth of S. aureus in the presence of selenium nanoparticles. Results of this study provided the first evidence of strongly inhibited growth of S. aureus in the presence of selenium nanoparticles after 3, 4, and 5 hours at 7.8, 15.5, and 31 μg/mL. The percentage of live bacteria also decreased in the presence of selenium nanoparticles. Therefore, this study suggests that selenium nanoparticles may be used to effectively prevent and treat S. aureus infections and thus should be further studied for such applications. PMID:21845045

  20. Panvascular Disease in Familial Hypercholesterolaemia Treated with Endovascular Simultaneous Bilateral Carotid Stenting.

    PubMed

    Alurkar, Anand; Karanam, Lakshmi Sudha Prasanna; Shah, Shripal; Mare, Pandurang

    2016-10-01

    Familial Hypercholesterolaemia (FH) is a monogenic autosomal dominant disorder affecting 1 in 500 individuals. We report a case of 32-year-old female with FH, previously not on any treatment, who presented with recurrent bilateral Middle Cerebral Artery (MCA) territory strokes and dyspnoea on exertion due to severe panvascualar disease involving descending aorta, innominate, subclavian, common carotid, internal carotid and coronary vessels. Her complete clinical work up was done and was started on lipid lowering drug treatment and low calorie diet. She underwent simultaneous bilateral carotid stenting followed by coronary artery bypass surgery at a later date. In the present scenario we want to emphasize the importance of early detection and treatment of individuals with FH, failing of which results in premature and accelerated atherosclerosis causing multisystemic vascular disease with significant morbidity and mortality. Screening of first degree relatives is important owing to the autosomal dominant inheritance pattern of the FH.

  1. Panvascular Disease in Familial Hypercholesterolaemia Treated with Endovascular Simultaneous Bilateral Carotid Stenting

    PubMed Central

    Alurkar, Anand; Shah, Shripal; Mare, Pandurang

    2016-01-01

    Familial Hypercholesterolaemia (FH) is a monogenic autosomal dominant disorder affecting 1 in 500 individuals. We report a case of 32-year-old female with FH, previously not on any treatment, who presented with recurrent bilateral Middle Cerebral Artery (MCA) territory strokes and dyspnoea on exertion due to severe panvascualar disease involving descending aorta, innominate, subclavian, common carotid, internal carotid and coronary vessels. Her complete clinical work up was done and was started on lipid lowering drug treatment and low calorie diet. She underwent simultaneous bilateral carotid stenting followed by coronary artery bypass surgery at a later date. In the present scenario we want to emphasize the importance of early detection and treatment of individuals with FH, failing of which results in premature and accelerated atherosclerosis causing multisystemic vascular disease with significant morbidity and mortality. Screening of first degree relatives is important owing to the autosomal dominant inheritance pattern of the FH. PMID:27891422

  2. Intensive Care Management of Patients with Cirrhosis.

    PubMed

    Olson, Jody C

    2018-06-01

    Cirrhosis is a major worldwide health problem which results in a high level of morbidity and mortality. Patients with cirrhosis who require intensive care support have high mortality rates of near 50%. The goal of this review is to address the management of common complications of cirrhosis in the ICU. Recent epidemiological studies have shown an increase in hospitalizations due to advanced liver disease with an associated increase in intensive care utilization. Given an increasing burden on the healthcare system, it is imperative that we strive to improve our management cirrhotic patients in the intensive care unit. Large studies evaluating the management of patients in the intensive care setting are lacking. To date, most recommendations are based on extrapolation of data from studies in cirrhosis outside of the ICU or by applying general critical care principles which may or may not be appropriate for the critically ill cirrhotic patient. Future research is required to answer important management questions.

  3. An integer batch scheduling model considering learning, forgetting, and deterioration effects for a single machine to minimize total inventory holding cost

    NASA Astrophysics Data System (ADS)

    Yusriski, R.; Sukoyo; Samadhi, T. M. A. A.; Halim, A. H.

    2018-03-01

    This research deals with a single machine batch scheduling model considering the influenced of learning, forgetting, and machine deterioration effects. The objective of the model is to minimize total inventory holding cost, and the decision variables are the number of batches (N), batch sizes (Q[i], i = 1, 2, .., N) and the sequence of processing the resulting batches. The parts to be processed are received at the right time and the right quantities, and all completed parts must be delivered at a common due date. We propose a heuristic procedure based on the Lagrange method to solve the problem. The effectiveness of the procedure is evaluated by comparing the resulting solution to the optimal solution obtained from the enumeration procedure using the integer composition technique and shows that the average effectiveness is 94%.

  4. A new analysis of the effects of the Asian crisis of 1997 on emergent markets

    NASA Astrophysics Data System (ADS)

    Mariani, M. C.; Liu, Y.

    2007-07-01

    This work is devoted to the study of the Asian crisis of 1997, and its consequences on emerging markets. We have done so by means of a phase transition model. We have analyzed the crashes on leading indices of Hong Kong (HSI), Turkey (XU100), Mexico (MMX), Brazil (BOVESPA) and Argentina (MERVAL). We were able to obtain optimum values for the critical date, corresponding to the most probable date of the crash. The estimation of the critical date was excellent except for the MERVAL index; this improvement is due to a previous analysis of the parameters involved. We only used data from before the true crash date in order to obtain the predicted critical date. This article's conclusions are largely obtained via ad hoc empirical methods.

  5. Microcalli Induction in Protoplasts Isolated from Embryogenic Callus of Date Palm.

    PubMed

    Titouh, Khayreddine; Boufis, Nazim; Khelifi, Lakhdar

    2017-01-01

    Date palm (Phoenix dactylifera L.) production is severely hampered due to several pests and diseases. Biotechnological tools such as protoplast fusion appear as an alternative to ensure rapid genetic improvement and multiplication of this species. However, establishment of an effective system of plant regeneration from protoplasts culture is a prerequisite for date palm somatic hybridization. In this chapter, we describe an effective protocol to induce microcalli in protoplasts isolated from nodular callus of important Algerian date palm cultivars. In this protocol, the main factors influencing the isolation (i.e., enzymatic solution, mannitol concentration, duration, and mode of maceration) of protoplasts from the calli of Algerian date palm cultivars were optimized. Purified protoplasts were cultured on a semisolid medium supplemented with a hormonal balance of auxin and cytokinin to obtain microcalli formation.

  6. 2 CFR 25.200 - Requirements for program announcements, regulations, and application instructions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Requirements for program announcements... on or after the effective date of this part; or (2) Has application or plan due dates after October 1... application or plan; (2) Maintain an active CCR registration with current information at all times during...

  7. 2 CFR 25.200 - Requirements for program announcements, regulations, and application instructions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Requirements for program announcements...) Is issued on or after the effective date of this part; or (2) Has application or plan due dates after... an application or plan; (2) Maintain an active CCR registration with current information at all times...

  8. 77 FR 16218 - Combined Notice of Filings #2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice...: Original Service Agreement No. 3246; Queue No. W1-119 to be effective 2/14/2012. Filed Date: 3/13/12... effective 2/14/2012. Filed Date: 3/13/12. Accession Number: 20120313-5026. Comments Due: 5 p.m. ET 4/3/12...

  9. 2 CFR 25.200 - Requirements for program announcements, regulations, and application instructions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Requirements for program announcements...) Is issued on or after the effective date of this part; or (2) Has application or plan due dates after... an application or plan; (2) Maintain an active CCR registration with current information at all times...

  10. 2 CFR 25.200 - Requirements for program announcements, regulations, and application instructions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Requirements for program announcements...) Is issued on or after the effective date of this part; or (2) Has application or plan due dates after... an application or plan; (2) Maintain an active CCR registration with current information at all times...

  11. 76 FR 25365 - Notice of Submission of Proposed Information Collection to OMB; County Data Record Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-04

    ... the ownership, rights and interests of land parcels and HUD is specifically interested in parcel data related to tax assessment, property sale, easement, lien, land use and condition. DATES: Comments Due Date... the ownership, rights and interests of land parcels and HUD is specifically interested in parcel data...

  12. 77 FR 73493 - Notice of Proposed Information Collection: Comment Request Family Self-Sufficiency Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-10

    .... DATES: Comments Due Date: February 8, 2013. ADDRESSES: Interested persons are invited to submit comments... model is needed because participant self-selection into FSS limits the ability to know whether program.... Tracking survey sample 3,000 1 Maximum of 1 hour over 3,000 hours. the tracking period, mainly to update...

  13. 77 FR 47156 - Self-Regulatory Organizations; New York Stock Exchange LLC; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-07

    ... to Extraordinary Market Volatility, To Extend the Effective Date of the Pilot Until February 4, 2013... provides for trading pauses in individual securities due to extraordinary market volatility, to extend the... extraordinary market volatility, to extend the effective date of the pilot by which such rule operates from the...

  14. 38 CFR 21.3047 - Extended period of eligibility due to physical or mental disability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Extended period of... Dependents' Educational Assistance Under 38 U.S.C. Chapter 35 Eligibility and Entitlement § 21.3047 Extended... surviving spouse shall elect the commencing date of an extended period of eligibility. The date chosen— (1...

  15. 38 CFR 21.3047 - Extended period of eligibility due to physical or mental disability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Extended period of... Dependents' Educational Assistance Under 38 U.S.C. Chapter 35 Eligibility and Entitlement § 21.3047 Extended... surviving spouse shall elect the commencing date of an extended period of eligibility. The date chosen— (1...

  16. 38 CFR 21.3047 - Extended period of eligibility due to physical or mental disability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Extended period of... Dependents' Educational Assistance Under 38 U.S.C. Chapter 35 Eligibility and Entitlement § 21.3047 Extended... surviving spouse shall elect the commencing date of an extended period of eligibility. The date chosen— (1...

  17. 78 FR 20908 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-08

    .... Description: UGI Storage Compliance Filing TL-96 to be effective 4/ 1/2013. Filed Date: 3/28/13. Accession... Eastern Pipe Line Company, LP. Description: Flow Through of Cash-Out Revenues filed on 3-28-13. Filed Date: 3/28/13. Accession Number: 20130328-5022. Comments Due: 5 p.m. ET 4/9/13. Docket Numbers: RP13-726...

  18. 78 FR 70066 - 60-Day Notice of Proposed Information Collection: FHA Stakeholder Feedback for the New FHA Single...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-22

    ... interested parties on the proposed collection of information. The purpose of this notice is to allow for 60 days of public comment. DATES: Comments Due Date: January 21, 2014. ADDRESSES: Interested persons are... simple, more directive language Aligning the flow of the handbook to the lender/mortgage process. Without...

  19. 77 FR 26029 - Privacy Act of 1974; Notice of a New System of Records, Department of Housing and Urban...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-02

    ... are received during or before this period which would result in a contrary determination. Comments Due... participation, other change of unit, Family Self Sufficiency/Welfare-to-Work (FSS/WTW) addendum only, annual... initial, date of birth, age on effective date of action, sex, relationship to head of household...

  20. 78 FR 26636 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-07

    ...: 20130429-5050. Comments Due: 5 p.m. ET 5/13/13. Docket Numbers: RP13-823-000. Applicants: CenterPoint... Operational Purchases and Sales Report for 12 Months Ending December 31, 2012. Filed Date: 4/29/13. Accession... Purchases and Sales of Gas Report for 12 Months Ending December 31, 2013. Filed Date: 4/29/13. Accession...

  1. 75 FR 45145 - Notice of Submission of Proposed Information Collection to OMB Final Endorsement of Credit...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-02

    ... requirement described below has been submitted to the Office of Management and Budget (OMB) for review, as... mortgagee/lender submits information to indicate the schedule of advances made on the project and the final advance to be disbursed immediately upon final endorsement. DATES: Comments Due Date: September 1, 2010...

  2. 78 FR 59013 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... be effective 9/18/2013. Filed Date: 9/18/13 Accession Number: 20130918-5042 Comments Due: 5 p.m. ET 10/9/13 Docket Numbers: ER10-2870-003 Applicants: TransCanada Power Marketing Ltd. Description: TransCanada Power Marketing Market Based Rate Tariff to be effective 9/18/2013. Filed Date: 9/18/13 Accession...

  3. 76 FR 13656 - Notice of Submission of Proposed Information Collection to OMB Economic Opportunities for Low and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ... Proposed Information Collection to OMB Economic Opportunities for Low and Very Low Income Persons AGENCY... and the use of businesses that employ low-income persons. DATES: Comments Due Date: April 13, 2011... following information: Title of Proposal: Economic Opportunities for Low and Very Low Income Persons. OMB...

  4. 76 FR 30182 - Notice of Submission of Proposed Information Collection to OMB Section 5(h) Homeownership Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-24

    ... Its Proposed Use: Public Housing Agencies (PHAs) maintain sales and financial records of their plan... comments on the subject proposal. Public Housing Agencies (PHAs) maintain sales and financial records of their plan. Residents may apply to PHAs to purchase units. DATES: Comments Due Date: June 23, 2011...

  5. 17 CFR 204.4 - Demand for payment-notice.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Demand for payment-notice. 204... TO DEBT COLLECTION Administrative Offset § 204.4 Demand for payment—notice. (a) Before offset is made... the debt; (2) The date when payment is due (not less than thirty days from the date of mailing or hand...

  6. Sharpening the U-Th Chronometer: Progress and Outlook

    NASA Astrophysics Data System (ADS)

    McLean, N. M.; Condon, D. J.; Henderson, G. M.; Richards, D. A.; Noble, S.; Mason, A.

    2013-12-01

    Uranium is incorporated into a variety of natural materials when they form, including carbonates like speleothems and corals. The two most abundant naturally occurring uranium isotopes, 238U and 235U, decay to 206Pb and 207Pb over long timescales with half-lives of 4.5 and 0.7 billion years respectively, but transition through several intermediate daughter isotopes with shorter half-lives first. Fractionation between these daughter isotopes, including 234U, 230Th, and 231Pa, and their parent isotopes, followed by their time-dependent return to secular equilibrium over the course of up to ~800 kyr, forms the basis for U-series geochronology, and allows speleothems and corals to be precisely dated. These carbonates often additionally incorporate chemical and isotopic signatures (e.g., trace elements, δ18O and δ13C) from the environment in which they form, and thus are some of the best dated paleoclimate archives, offering clues about past and future conditions for life on Earth. Over the past decade, the analytical precision of U-series isotope measurements has improved dramatically, largely due to the steadily increasing sensitivity of multiple-collector inductively coupled plasma mass spectrometry (MC-ICP-MS). Analytical uncertainties in U-Th dates now approach or are better than 0.1% (2σ), for instance ×100 years for a speleothem or coral that is 130 kyr old (Cheng et al., 2013). However, the accuracy of U-series dates also depends on the accuracy of tracer calibrations, reference solutions and data reduction protocols, which has not kept pace in many laboratories. This means that dates measured in different labs, while impressively precise, may not be directly comparable. To address issues of inter-laboratory bias and improve the accuracy and inter-comparability of U-Th dates, we have instigated work in three related directions. First, we report on the mixing of three synthetic U-Th age solutions, created by combining high-purity mono-isotopic solutions to mimic the isotopic composition of commonly analyzed materials. These age solutions will form the basis for an inter-laboratory comparison and serve as international reference materials for assessing long-term reproducibility. Second is the creation of several U-Th gravimetric solutions, which can be used to calibrate the mixed 229Th-236U×233U tracers used in the community without having to rely on materials assumed to be in secular equilibrium. Tracers calibrated against these solutions, and therefore U-Th dates measured with these tracers, will be fully metrologically traceable. Finally, we report progress on and important considerations in developing data reduction and uncertainty propagation protocols for calculating U-Th dates and constructing and interpreting U-Th age models. Reference: Cheng et al. (2013) EPSL 371-372, 82-91

  7. A new look on Imperial Porphyry: a famous ancient dimension stone from the Eastern Desert of Egypt—petrogenesis and cultural relevance

    NASA Astrophysics Data System (ADS)

    Abu El-Enen, Mahrous M.; Lorenz, Joachim; Ali, Kamal A.; von Seckendorff, Volker; Okrusch, Martin; Schüssler, Ulrich; Brätz, Helene; Schmitt, Ralf-Thomas

    2018-03-01

    Imperial Porphyry, a famous dimension stone of spectacular purple color, was quarried in the Mons Porphyrites area north of Jabal Dokhan in the Eastern Desert of Egypt, from the beginning of the first until the middle of the fifth century AD. During this period, the valuable material was processed as decorative stone and was used for objects of art, reserved exclusively for the Imperial court of the Roman Empire. Later on, only antique spoils of smaller or bigger size have been re-used for these purposes. The Imperial Porphyry is a porphyritic rock of trachyandesitic to dacitic composition that occurs in the uppermost levels of shallow subvolcanic sill-like intrusions, forming a member of the Dokhan Volcanic Suite. Its purple color is mainly due to dispersed flakes of hematite, resulting from hydrothermal alteration of a dark green Common Porphyry of similar composition, underlying the Imperial Porphyry. Both, the Common Porphyry and the purple Imperial Porphyry', are extensively exposed in the Roman quarries. Contacts between Common and Imperial Porphyry are irregular and gradational. In both rock types, intrusive breccias are frequent, indicating a complex intrusion history. U-Th-Pb zircon geochronology on two samples of Imperial Porphyry and one sample of the Common Porphyry yielded an age range of 609-600 Ma, thus confirming earlier results of radiometric dating. Geochemical evidence indicates that both the Imperial and the Common Porphyry are of medium- to high-K calc-alkaline affinity. The magmas have formed by partial melting of a subduction-modified upper mantle. The subsequent intrusion took place within a highly extended terrane (HET).

  8. ADMultiImg: a novel missing modality transfer learning based CAD system for diagnosis of MCI due to AD using incomplete multi-modality imaging data

    NASA Astrophysics Data System (ADS)

    Liu, Xiaonan; Chen, Kewei; Wu, Teresa; Weidman, David; Lure, Fleming; Li, Jing

    2018-02-01

    Alzheimer's Disease (AD) is the most common cause of dementia and currently has no cure. Treatments targeting early stages of AD such as Mild Cognitive Impairment (MCI) may be most effective to deaccelerate AD, thus attracting increasing attention. However, MCI has substantial heterogeneity in that it can be caused by various underlying conditions, not only AD. To detect MCI due to AD, NIA-AA published updated consensus criteria in 2011, in which the use of multi-modality images was highlighted as one of the most promising methods. It is of great interest to develop a CAD system based on automatic, quantitative analysis of multi-modality images and machine learning algorithms to help physicians more adequately diagnose MCI due to AD. The challenge, however, is that multi-modality images are not universally available for many patients due to cost, access, safety, and lack of consent. We developed a novel Missing Modality Transfer Learning (MMTL) algorithm capable of utilizing whatever imaging modalities are available for an MCI patient to diagnose the patient's likelihood of MCI due to AD. Furthermore, we integrated MMTL with radiomics steps including image processing, feature extraction, and feature screening, and a post-processing for uncertainty quantification (UQ), and developed a CAD system called "ADMultiImg" to assist clinical diagnosis of MCI due to AD using multi-modality images together with patient demographic and genetic information. Tested on ADNI date, our system can generate a diagnosis with high accuracy even for patients with only partially available image modalities (AUC=0.94), and therefore may have broad clinical utility.

  9. Justice and Due Process.

    ERIC Educational Resources Information Center

    McKinney-Browning, Mabel C.

    1981-01-01

    Presents a directory of educational materials in the areas of justice and due process. Materials are listed in three categories--films, books, and project-created materials. For each entry, information is presented on title, author, publisher or developer, publication date, price, and annotation. (DB)

  10. 77 FR 45346 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    .../20/12. Accession Number: 20120720-5000. Comments Due: 5 p.m. ET 8/10/12. Docket Numbers: ER12-1586...-1586 to be effective 4/30/2012. Filed Date: 7/20/12. Accession Number: 20120720-5002. Comments Due: 5 p...

  11. 25 CFR 162.546 - What requirements for due diligence must a WSR lease include?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Leases § 162.546 What requirements for due... lessee to: (1) Commence installation of energy facilities within 2 years after the effective date of the...

  12. 25 CFR 162.546 - What requirements for due diligence must a WSR lease include?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... WATER LEASES AND PERMITS Wind and Solar Resource Leases Wsr Leases § 162.546 What requirements for due... lessee to: (1) Commence installation of energy facilities within 2 years after the effective date of the...

  13. Evidence of a prolonged drought ca. 4200 yr BP correlated with prehistoric settlement abandonment from the Gueldaman GLD1 Cave, N-Algeria

    NASA Astrophysics Data System (ADS)

    Ruan, J.; Kherbouche, F.; Genty, D.; Blamart, D.; Cheng, H.; Dewilde, F.; Hachi, S.; Edwards, L. R.; Régnier, E.; Michelot, J.-L.

    2015-07-01

    Middle Holocene cultures have been widely studied round the E-Mediterranean basin in the last 30 years and past cultural activities have been commonly linked with regional climate changes. However, in many cases such linkage is equivocal, in part due to existing climatic evidence that has been derived from areas outside the distribution of ancient settlements, leading to uncertainty from complex spatial heterogeneity in both climate and demography. A few high-resolution well-dated paleoclimate records were recently established using speleothems in the Central and E-Mediterranean basin, however, the scarcity of such records in the western part of the Mediterranean prevents us from correlating past climate evolutions across the basin and deciphering climate-culture relation at fine time scales. Here we report the first decadal-resolved Mid-Holocene climate proxy records from the W-Mediterranean basin based on the stable carbon and oxygen isotopes analyses of two U/Th dated stalagmites from the Gueldaman GLD1 Cave in N-Algeria. Comparison of our records with those from Italy and Israel reveals synchronous (multi) centennial dry phases centered at ca. 5600, ca. 5200 and ca. 4200 yr BP across the Mediterranean basin. New calibrated radiocarbon dating constrains reasonably well the age of rich anthropogenic deposits (e.g., faunal remains, pottery, charcoal) excavated inside the cave, which allows the comparison between in situ evidence of human occupation and of climate change. This approach shows that the timing of a prolonged drought at ca. 4400-3800 yr BP blankets the onset of cave abandonment shortly after ca. 4403 cal yr BP, supporting the hypothesis that a climate anomaly may have played a role in this cultural disruption.

  14. Evidence of a prolonged drought ca. 4200 yr BP correlated with prehistoric settlement abandonment from the Gueldaman GLD1 Cave, Northern Algeria

    NASA Astrophysics Data System (ADS)

    Ruan, J.; Kherbouche, F.; Genty, D.; Blamart, D.; Cheng, H.; Dewilde, F.; Hachi, S.; Edwards, R. L.; Régnier, E.; Michelot, J.-L.

    2016-01-01

    Middle Holocene cultures have been widely studied around the Eastern-Mediterranean basin in the last 30 years and past cultural activities have been commonly linked with regional climate changes. However, in many cases such linkage is equivocal, in part due to existing climatic evidence that has been derived from areas outside the distribution of ancient settlements, leading to uncertainty from complex spatial heterogeneity in both climate and demography. A few high-resolution well-dated paleoclimate records were recently established using speleothems in the Central and Eastern-Mediterranean basin, however, the scarcity of such records in the western part of the Mediterranean prevents us from correlating past climate evolutions across the basin and deciphering climate-culture relation at fine timescales. Here we report the first decadal-resolved Mid-Holocene climate proxy records from the Western-Mediterranean basin based on the stable carbon and oxygen isotopes analyses of two U/Th dated stalagmites from the Gueldaman GLD1 Cave in Northern Algeria. Comparison of our records with those from Italy and Israel reveals synchronous (multi) centennial dry phases centered at ca. 5600, ca. 5200 and ca. 4200 yr BP across the Mediterranean basin. New calibrated radiocarbon dating constrains reasonably well the age of rich anthropogenic deposits (e.g., faunal remains, pottery, charcoal) excavated inside the cave, which allows the comparison between in situ evidence of human occupation and of climate change. This approach shows that the timing of a prolonged drought at ca. 4400-3800 yr BP blankets the onset of cave abandonment shortly after ca. 4403 cal yr BP, supporting the hypothesis that a climate anomaly may have played a role in this cultural disruption.

  15. Combined structural analysis and dating of authigenic/synkinematic illite: A step towards unravelling brittle faulting processes in time and space

    NASA Astrophysics Data System (ADS)

    Viola, Giulio

    2017-04-01

    Faulting accommodates momentous deformation and its style reflects the complex interplay of often transient processes such as friction, fluid flow and rheological changes within generally dilatant systems. Brittle faults are thus unique archives of the stress state and the physical and chemical conditions at the time of both initial strain localization and subsequent slip(s) during structural reactivation. Opening those archives, however, may be challenging due to the commonly convoluted (if not even chaotic) nature of brittle fault architectures and fault rocks. This is because, once formed, faults are extremely sensitive to variations in stress field and environmental conditions and are prone to readily slip in a variety of conditions, also in regions affected by only weak, far-field stresses. The detailed, multi-scalar structural analysis of faults and of fault rocks has to be the starting point for any study aiming at reconstructing the complex framework of brittle deformation. However, considering that present-day exposures of faults only represent the end result of the faults' often protracted and heterogeneous histories, the obtained structural and mechanical results have to be integrated over the life span of the studied fault system. Dating of synkinematic illite/muscovite to constrain the time-integrated evolution of faults is therefore the natural addition to detailed structural studies. By means of selected examples it will be demonstrated how careful structural analysis integrated with illite characterization and K-Ar dating allows the high-resolution reconstruction of brittle deformation histories and, in turn, multiple constraints to be placed on strain localization, deformation mechanisms, fluid flow, mineral alteration and authigenesis within actively deforming brittle fault rocks. Complex and long brittle histories can thus be reconstructed and untangled in any tectonic setting.

  16. CUMMULATIVE EFFECTS OF ADMINISTRATION MIXTURES OF “ANTIANDROGENS” IN RATS: A NEW FRAMEWORK BASED UPON COMMON SYSTEMS RATHER THAN COMMON MECHANISMS

    EPA Science Inventory

    Since humans and wildlife are exposed to more than one chemical at a time, concern has arisen about the effects of complex mixtures on reproduction and development. To date, different regulatory groups have not yet developed consistent approaches to conducting assessments of the ...

  17. 76 FR 16858 - Proposed Information Collection (Statement of Marital Relationship); Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... validity of a common law marriage. DATES: Written comments and recommendations on the proposed collection.... VA uses the information collected to determine whether a common law marriage was valid under the law of the place where the parties resided at the time of the marriage or under the law of the place...

  18. Evidence for the Buried "Pre-Noachian" Crust Pre-Dating the Oldest Observed Surface Units on Mars

    NASA Technical Reports Server (NTRS)

    Frey, H. V.; Frey, E. L.; Hartmann, W. K.; Tanaka, K. L. T.

    2003-01-01

    MOLA gridded data shows clear evidence for Quasi-Circular Depressions not visible on images in Early Noachian (EN) terrain units on Mars. We suggest these are buried impact basins that pre-date the superimposed craters whose high density makes these EN units the oldest visible at the surface of Mars. There is crust older than the oldest visible terrain units on Mars, and these EN units cannot date from 4.6 BYA. These and other Noa-chian units have similar total (visible + buried) crater retention ages, suggesting a common "pre-Noachian" crustal age OR crater saturation beyond which we cannot see.

  19. Evidence for Buried "Pre-Noachian" Crust Pre-Dating the Oldest Observed Surface Units on Mars

    NASA Technical Reports Server (NTRS)

    Frey, H. V.; Frey, E. L.; Hartmann, W. K.; Tanaka, K. L. T.

    2004-01-01

    MOLA gridded data shows clear evidence for Quasi-Circular Depressions not visible on images in Early Noachian (EN) terrain units on Mars. We suggest these are buried impact basins that pre-date the superimposed craters whose high density makes these EN units the oldest visible at the surface of Mars. There is crust older than the oldest visible terrain units on Mars, and these EN units cannot date from 4.6 BYA. These and other Noachian units have similar total (visible + buried) crater retention ages, suggesting a common "pre-Noachian" crustal age OR crater saturation beyond which we cannot see.

  20. 77 FR 5005 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... Due: 5 p.m. ET 1/31/12. Docket Numbers: RP12-322-000. Applicants: Gulf Crossing Pipeline Company LLC.../2011. Filed Date: 1/17/12. Accession Number: 20120117-5211. Comments Due: 5 p.m. ET 1/30/12. Docket.... Accession Number: 20120119-5105. Comments Due: 5 p.m. ET 1/31/12. Docket Numbers: RP12-319-000. Applicants...

  1. 78 FR 716 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-04

    ...: 20121227-5139. Comments Due: 5 p.m. ET 1/8/13. Docket Numbers: RP13-417-000. Applicants: Florida Gas... Date: 12/28/12. Accession Number: 20121228-5045. Comments Due: 5 p.m. ET 1/9/13. Docket Numbers: RP13.... Comments Due: 5 p.m. ET 1/9/13. Docket Numbers: RP13-419-000. Applicants: Midwestern Gas Transmission...

  2. 77 FR 34377 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... Number: 20120601-5160. Comments Due: 5 p.m. ET 6/13/12. Docket Numbers: RP12-783-000. Applicants: ANR... Number: 20120601-5176. Comments Due: 5 p.m. ET 6/13/12. Docket Numbers: RP12-784-000. Applicants: Elba.... Filed Date: 6/1/12. Accession Number: 20120601-5183. Comments Due: 5 p.m. ET 6/13/12. Docket Numbers...

  3. Adolescent Perceptions of Dating Violence: A Qualitative Study.

    PubMed

    Taylor, Sarah; Calkins, Carrie A; Xia, Yan; Dalla, Rochelle L

    2017-08-01

    Scholars have identified dating violence as a public health issue among adolescents. Yet, minimal research has detailed adolescents' perceptions of dating violence, specifically gender differences in perceptions. Research suggests that in order for dating violence prevention and intervention to be effective, services need to be delivered in a manner that is understood by adolescents. Therefore, this study used a qualitative phenomenology study to investigate adolescents' perceptions of dating violence, including gender differences in adolescents' perceptions. Thirty adolescents between the ages of 14 and 19 from a Midwest public high school participated in focus groups. Focus group participants were asked semistructured interview questions regarding the definition of dating violence, risk and protective factors for dating violence, support for victims and perpetrators, and prevention efforts. Data were analyzed using qualitative content analysis methods, and common themes were identified. Adolescents' language revealed gender differences in perceptions toward dating violence. Males perceive dating violence through action, perpetration, and physical consequences. Females discuss dating violence by relating to the victim and the victim's emotions. Although gender differences existed in participants' perceptions, both males and females explained that dating violence is more often perpetrated by females, despite the view from society that males are more likely to perpetrate dating violence. Findings suggest that schools, practitioners, and policy makers are not meeting the needs of adolescents in regard to dating violence prevention and intervention. Prevention and intervention efforts could be improved by delivering education and services using language that adolescents find relevant. Findings also suggest that adolescents may benefit from prevention and intervention with gender specific components.

  4. Considerations for successful cosmogenic 3He dating in accessory phases

    NASA Astrophysics Data System (ADS)

    Amidon, W. H.; Farley, K. A.; Rood, D. H.

    2008-12-01

    We have been working to develop cosmogenic 3He dating of phases other than the commonly dated olivine and pyroxene, especially apatite and zircon. Recent work by Dunai et al. underscores that cosmogenic 3He dating is complicated by 3He production via 6Li(n,α) 3H --> 3He. The reacting thermal neutrons can be produced from three distinct sources; nucleogenic processes (3Henuc), muon interactions (3Hemu), and by high-energy "cosmogenic" neutrons (3Hecn). Accurate cosmogenic 3He dating requires determination of the relative fractions of Li-derived and spallation derived 3He. An important complication for the fine-grained phases we are investigating is that both spallation and the 6Li reaction eject high energy particles, with consequences for redistribution of 3He among phases in a rock. Although shielded samples can be used to estimate 3Henuc, they do not conatin the 3Hecn component produced in the near surface. To calculate this component, we propose a procedure in which the bulk rock chemistry, helium closure age, 3He concentration, grain size and Li content of the target mineral are measured in a shielded sample. The average Li content of the adjacent minerals can then be calculated, which in turn allows calculation of the 3Hecn component in surface exposed samples of the same lithology. If identical grain sizes are used in the shielded and surface exposed samples, then "effective" Li can be calculated directly from the shielded sample, and it may not be necessary to measure Li at all. To help validate our theoretical understanding of Li-3He production, and to constrain the geologic contexts in which cosmogenic 3He dating with zircon and apatite is likely to be successful, results are presented from four different field locations. For example, results from ~18 Ky old moraines in the Sierra Nevada show that the combination of low Li contents and high closure ages (>50 My) creates a small 3Hecn component (2%) but a large 3Henuc component (40-70%) for zircon and apatite. In contrast the combination of high Li contents and a young closure age (0.6 My) in rhyolite from the Coso volcanic field leads to a large 3Hecn component (30%) and small 3Henuc component (5%) in zircon. Analysis of samples from a variety of lithologies shows that zircon and apatite tend to be low in Li (1-10 ppm), but are vulnerable to implantation of 3He from adjacent minerals due to their small grain size, especially from minerals like biotite and hornblende. This point is well illustrated by data from both the Sierra Nevada and Coso examples, in which there is a strong correlation between grain size and 3He concentration for zircons due to implantation. In contrast, very large zircons (150>125 um width) obtained from shielded samples of the Shoshone Falls rhyolite (SW Idaho) do not contain a significant implanted component. Thus, successful 3He dating of accessory phases requires low Li content (<10 ppm) in the target mineral and either 1) low Li in adjacent minerals, or 2) the use of large grain sizes (>100 um). In high-Li cases, the fraction of 3Henuc is minimized in samples with young helium closure ages or longer duration of exposure. However because the 3Hecn/3Hespall ratio is fixed for a given Li content, longer exposure will not reduce the fraction of 3Hecn.

  5. Variability common to first leaf dates and snowpack in the western conterminous United States

    USGS Publications Warehouse

    McCabe, Gregory J.; Betancourt, Julio L.; Pederson, Gregory T.; Schwartz, Mark D.

    2013-01-01

    Singular value decomposition is used to identify the common variability in first leaf dates (FLDs) and 1 April snow water equivalent (SWE) for the western United States during the period 1900–2012. Results indicate two modes of joint variability that explain 57% of the variability in FLD and 69% of the variability in SWE. The first mode of joint variability is related to widespread late winter–spring warming or cooling across the entire west. The second mode can be described as a north–south dipole in temperature for FLD, as well as in cool season temperature and precipitation for SWE, that is closely correlated to the El Niño–Southern Oscillation. Additionally, both modes of variability indicate a relation with the Pacific–North American atmospheric pattern. These results indicate that there is a substantial amount of common variance in FLD and SWE that is related to large-scale modes of climate variability.

  6. Chilling and Drought Stresses in Crop Plants: Implications, Cross Talk, and Potential Management Opportunities

    PubMed Central

    Hussain, Hafiz A.; Hussain, Saddam; Khaliq, Abdul; Ashraf, Umair; Anjum, Shakeel A.; Men, Shengnan; Wang, Longchang

    2018-01-01

    Plants face a combination of different abiotic stresses under field conditions which are lethal to plant growth and production. Simultaneous occurrence of chilling and drought stresses in plants due to the drastic and rapid global climate changes, can alter the morphological, physiological and molecular responses. Both these stresses adversely affect the plant growth and yields due to physical damages, physiological and biochemical disruptions, and molecular changes. In general, the co-occurrence of chilling and drought combination is even worse for crop production rather than an individual stress condition. Plants attain various common and different physiological and molecular protective approaches for tolerance under chilling and drought stresses. Nevertheless, plant responses to a combination of chilling and drought stresses are unique from those to individual stress. In the present review, we summarized the recent evidence on plant responses to chilling and drought stresses on shared as well as unique basis and tried to find a common thread potentially underlying these responses. We addressed the possible cross talk between plant responses to these stresses and discussed the potential management strategies for regulating the mechanisms of plant tolerance to drought and/or chilling stresses. To date, various novel approaches have been tested in minimizing the negative effects of combine stresses. Despite of the main improvements there is still a big room for improvement in combination of drought and chilling tolerance. Thus, future researches particularly using biotechnological and molecular approaches should be carried out to develop genetically engineered plants with enhanced tolerance against these stress factors. PMID:29692787

  7. Foundational Methane Propulsion Related Technology Efforts, and Challenges for Applications to Human Exploration Beyond Earth Orbit

    NASA Technical Reports Server (NTRS)

    Brown, Thomas; Klem, Mark; McRight, Patrick

    2016-01-01

    Current interest in human exploration beyond earth orbit is driving requirements for high performance, long duration space transportation capabilities. Continued advancement in photovoltaic power systems and investments in high performance electric propulsion promise to enable solar electric options for cargo delivery and pre-deployment of operational architecture elements. However, higher thrust options are required for human in-space transportation as well as planetary descent and ascent functions. While high thrust requirements for interplanetary transportation may be provided by chemical or nuclear thermal propulsion systems, planetary descent and ascent systems are limited to chemical solutions due to their higher thrust to weight and potential planetary protection concerns. Liquid hydrogen fueled systems provide high specific impulse, but pose challenges due to low propellant density and the thermal issues of long term propellant storage. Liquid methane fueled propulsion is a promising compromise with lower specific impulse, higher bulk propellant density and compatibility with proposed in-situ propellant production concepts. Additionally, some architecture studies have identified the potential for commonality between interplanetary and descent/ascent propulsion solutions using liquid methane (LCH4) and liquid oxygen (LOX) propellants. These commonalities may lead to reduced overall development costs and more affordable exploration architectures. With this increased interest, it is critical to understand the current state of LOX/LCH4 propulsion technology and the remaining challenges to its application to beyond earth orbit human exploration. This paper provides a survey of NASA's past and current methane propulsion related technology efforts, assesses the accomplishments to date, and examines the remaining risks associated with full scale development.

  8. Progress in the development of immunoanalytical methods incorporating recombinant antibodies to small molecular weight biotoxins.

    PubMed

    Kavanagh, Owen; Elliott, Christopher T; Campbell, Katrina

    2015-04-01

    Rapid immunoanalytical screening of food and environmental samples for small molecular weight (hapten) biotoxin contaminations requires the production of antibody reagents that possess the requisite sensitivity and specificity. To date animal-derived polyclonal (pAb) and monoclonal (mAb) antibodies have provided the binding element of the majority of these assays but recombinant antibodies (rAb) isolated from in vitro combinatorial phage display libraries are an exciting alternative due to (1) circumventing the need for experimental animals, (2) speed of production in commonly used in vitro expression systems and (3) subsequent molecular enhancement of binder performance. Short chain variable fragments (scFv) have been the most commonly employed rAb reagents for hapten biotoxin detection over the last two decades but antibody binding fragments (Fab) and single domain antibodies (sdAb) are increasing in popularity due to increased expression efficiency of functional binders and superior resistance to solvents. rAb-based immunochromatographic assays and surface plasmon resonance (SPR) biosensors have been reported to detect sub-regulatory levels of fungal (mycotoxins), marine (phycotoxins) and aquatic biotoxins in a wide range of food and environmental matrices, however this technology has yet to surpass the performances of the equivalent mAb- and pAb-based formats. As such the full potential of rAb technology in hapten biotoxin detection has yet to be achieved, but in time the inherent advantages of engineered rAb are set to provide the next generation of ultra-high performing binder reagents for the rapid and specific detection of hapten biotoxins.

  9. 78 FR 27298 - Proposed Collection; Comment Request for Regulation Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... Foreign Tax Credit; Notification and Adjustment Due to Foreign Tax Redeterminations. DATES: [email protected] . SUPPLEMENTARY INFORMATION: Title: Foreign Tax Credit; Notification and Adjustment Due to Foreign Tax Redeterminations. OMB Number: 1545-1056. Regulation Project Number: REG-209020-86 (formerly...

  10. Radiocarbon dating late Quaternary loess deposits using small terrestrial gastropod shells

    USGS Publications Warehouse

    Pigati, Jeff S.; McGeehin, John P.; Muhs, Daniel R.; Bettis, E. Arthur

    2013-01-01

    Constraining the ages and mass accumulation rates of late Quaternary loess deposits is often difficult because of the paucity of organic material typically available for 14C dating and the inherent limitations of luminescence techniques. Radiocarbon dating of small terrestrial gastropod shells may provide an alternative to these methods as fossil shells are common in loess and contain ∼12% carbon by weight. Terrestrial gastropod assemblages in loess have been used extensively to reconstruct past environmental conditions but have been largely ignored for dating purposes. Here, we present the results of a multi-faceted approach to understanding the potential for using small terrestrial gastropod shells to date loess deposits in North America. First, we compare highly resolved 14C ages of well-preserved wood and gastropod shells (Succineidae) recovered from a Holocene loess section in Alaska. Radiocarbon ages derived from the shells are nearly identical to wood and plant macrofossil ages throughout the section, which suggests that the shells behaved as closed systems with respect to carbon for at least the last 10 ka (thousands of calibrated 14C years before present). Second, we apply 14C dating of gastropod shells to late Pleistocene loess deposits in the Great Plains using stratigraphy and independent chronologies for comparison. The new shell ages require less interpretation than humic acid radiocarbon ages that are commonly used in loess studies, provide additional stratigraphic coverage to previous dating efforts, and are in correct stratigraphic order more often than their luminescence counterparts. Third, we show that Succineidae shells recovered from historic loess in the Matanuska River Valley, Alaska captured the 20th century 14C bomb spike, which suggests that the shells can be used to date late Holocene and historic-aged loess. Finally, results from Nebraska and western Iowa suggest that, similar to other materials, shell ages approaching ∼40 ka should be viewed with caution as they may reflect trace amounts of contamination. In sum, our results show that small terrestrial gastropod shells, especially from the Succineidae family, provide reliable ages for late Quaternary loess deposits in North America.

  11. Return to work of workers without a permanent employment contract, sick-listed due to a common mental disorder: design of a randomised controlled trial.

    PubMed

    Lammerts, Lieke; Vermeulen, Sylvia J; Schaafsma, Frederieke G; van Mechelen, Willem; Anema, Johannes R

    2014-06-12

    Workers without a permanent employment contract represent a vulnerable group within the working population. Mental disorders are a major cause of sickness absence within this group. Common mental disorders are stress-related, depressive and anxiety disorders. To date, little attention has been paid to effective return to work interventions for this type of sick-listed workers. Therefore, a participatory supportive return to work program has been developed. It combines elements of a participatory return to work program, integrated care and direct placement in a competitive job.The objective of this paper is to describe the design of a randomised controlled trial to evaluate the cost-effectiveness of this program compared to care as usual. The cost-effectiveness of the participatory supportive return to work program will be examined in a randomised controlled trial with a follow-up of twelve months.The program strongly involves the sick-listed worker in the identification of obstacles for return to work and possible solutions, resulting in a consensus based action plan. This plan will be used as a starting point for the search of suitable competitive employment with support of a rehabilitation agency. During this process the insurance physician of the sick-listed worker contacts other caregivers to promote integrated care.Workers eligible to participate in this study have no permanent employment contract, have applied for a sickness benefit at the Dutch Social Security Agency and are sick-listed between two and fourteen weeks due to mental health problems.The primary outcome measure is the duration until first sustainable return to work in a competitive job. Outcomes are measured at baseline and after three, six, nine and twelve months. If the participatory supportive return to work program proves to be cost-effective, the social security system, the sick-listed worker and society as a whole will benefit. A cost-effective return to work program will lead to a reduction of costs related to sickness absence. For the sick-listed worker a cost-effective program results in earlier sustainable return to work, which can be associated with both social and health benefits. The trial registration number and date is NTR3563, August 7, 2012.

  12. Return to work of workers without a permanent employment contract, sick-listed due to a common mental disorder: design of a randomised controlled trial

    PubMed Central

    2014-01-01

    Background Workers without a permanent employment contract represent a vulnerable group within the working population. Mental disorders are a major cause of sickness absence within this group. Common mental disorders are stress-related, depressive and anxiety disorders. To date, little attention has been paid to effective return to work interventions for this type of sick-listed workers. Therefore, a participatory supportive return to work program has been developed. It combines elements of a participatory return to work program, integrated care and direct placement in a competitive job. The objective of this paper is to describe the design of a randomised controlled trial to evaluate the cost-effectiveness of this program compared to care as usual. Methods/Design The cost-effectiveness of the participatory supportive return to work program will be examined in a randomised controlled trial with a follow-up of twelve months. The program strongly involves the sick-listed worker in the identification of obstacles for return to work and possible solutions, resulting in a consensus based action plan. This plan will be used as a starting point for the search of suitable competitive employment with support of a rehabilitation agency. During this process the insurance physician of the sick-listed worker contacts other caregivers to promote integrated care. Workers eligible to participate in this study have no permanent employment contract, have applied for a sickness benefit at the Dutch Social Security Agency and are sick-listed between two and fourteen weeks due to mental health problems. The primary outcome measure is the duration until first sustainable return to work in a competitive job. Outcomes are measured at baseline and after three, six, nine and twelve months. Discussion If the participatory supportive return to work program proves to be cost-effective, the social security system, the sick-listed worker and society as a whole will benefit. A cost-effective return to work program will lead to a reduction of costs related to sickness absence. For the sick-listed worker a cost-effective program results in earlier sustainable return to work, which can be associated with both social and health benefits. Trial registration The trial registration number and date is NTR3563, August 7, 2012. PMID:24919561

  13. 40 CFR Table 8 to Subpart Ppp of... - Routine Reports Required by This Subpart

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-month period. See § 63.1439(e)(6)(i) for the due date for this report. § 63.1439(e)(6)(iii) Quarterly... months prior to compliance date.New affected sources: with the application for approval of construction... end of each quarter. § 63.506(e)(7)(i) Storage Vessels Notification of Inspection At least 30 days...

  14. 40 CFR Table 8 to Subpart Ppp of... - Routine Reports Required by This Subpart

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-month period. See § 63.1439(e)(6)(i) for the due date for this report. § 63.1439(e)(6)(iii) Quarterly... months prior to compliance date.New affected sources: with the application for approval of construction... end of each quarter. § 63.506(e)(7)(i) Storage Vessels Notification of Inspection At least 30 days...

  15. 76 FR 36318 - Safety Zone; Waterway Closure, Morgan City-Port Allen Route From Mile Marker 0 to Port Allen Lock

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-22

    ... to hazards associated with rising flood water. DATES: Effective Date: this rule is effective in the..., vessels and tows from the hazards associated with rising flood water on the Morgan City-Port Allen Route... system, vessels and tows from destruction, loss or injury due to the hazards associated with rising flood...

  16. 17 CFR 204.4 - Demand for payment-notice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., a written notice will be sent to the debtor. This notice will include: (1) The type and amount of the debt; (2) The date when payment is due (not less than thirty days from the date of mailing or hand... of the debtor to enter into a written agreement with the agency to repay the debt in some other way...

  17. 78 FR 12306 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-22

    ... effective 4/1/2017. Filed Date: 2/12/13. Accession Number: 20130212-5025. Comments Due: 5 p.m. e.t. 2/25/13... Secretary [FR Doc. 2013-04076 Filed 2-21-13; 8:45 am] BILLING CODE 6717-01-P .... Description: Duke Energy Carolinas 4-1-2013 Neg Rate to be effective 4/1/2013. Filed Date: 2/12/13. Accession...

  18. 78 FR 8638 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... Change To Delay the Operative Date of Rule 11.20A Regarding Market-Wide Circuit Breakers Due to... the market- wide circuit breakers on a pilot basis for a period scheduled to start on February 4, 2013... changed to April 8, 2013. The proposal would delay the operative date of the market-wide circuit breaker...

  19. Dating furniture and coopered vessels without waney edge - Reconstructing historical wood-working in Austria with the help of dendrochronology.

    PubMed

    Klein, Andrea; Nemestothy, Sebastian; Kadnar, Julia; Grabner, Michael

    In the present study, 208 furniture and 168 coopered vessels from three Austrian museums were examined. Dendrochronology was used to date objects and to extract further information such as the necessary time for seasoning, wood loss through wood-working and methods of construction. In most cases sampling was done by sanding the cross section and making digital photographs using a picture frame and measuring digitally. The dendrochronological dates of the sampled furniture range between 1524 and 1937. The group of furniture includes cupboards, chests, tables, benches, commodes and beds. In many cases furniture was artfully painted and sometimes even shows a painted year. With the help of dendrochronology it was proved that some objects had been painted for some time after construction, or had been over-painted. Most furniture, however, was painted immediately after completion. In this case, the seasoning and storage time of the boards and the wood loss due to shaping can be verified. As an average value, 14 years have passed between the dendrochronological date of the outermost ring and the painting. The time span includes time of seasoning and storage and the rings lost by wood-working. This leads, on the one hand to a short storage time of less than 10 years and on the other hand to very little wood loss due to manufacturing. Those boards being less shaped turned out to be back panels of cupboards, therefore they are recommended to be sampled for dating. Coopered vessels were dated between 1612 and 1940. There was evidence that staves were split and not sawn in many cases. The staves were often split out of the outermost part of the tree and hardly any wood was worked away which was proved by the close dendrochronological dates of the single staves of a vessel. Since there is a short time of storage and only little wood loss through wood-working, dating of objects without a waney edge becomes reasonable.

  20. Uranium series, volcanic rocks

    USGS Publications Warehouse

    Vazquez, Jorge A.

    2014-01-01

    Application of U-series dating to volcanic rocks provides unique and valuable information about the absolute timing of crystallization and differentiation of magmas prior to eruption. The 238U–230Th and 230Th-226Ra methods are the most commonly employed for dating the crystallization of mafic to silicic magmas that erupt at volcanoes. Dates derived from the U–Th and Ra–Th methods reflect crystallization because diffusion of these elements at magmatic temperatures is sluggish (Cherniak 2010) and diffusive re-equilibration is insignificant over the timescales (less than or equal to 10^5 years) typically associated with pre-eruptive storage of nearly all magma compositions (Cooper and Reid 2008). Other dating methods based on elements that diffuse rapidly at magmatic temperatures, such as the 40Ar/39Ar and (U–Th)/He methods, yield dates for the cooling of magma at the time of eruption. Disequilibrium of some short-lived daughters of the uranium series such as 210Po may be fractionated by saturation of a volatile phase and can be employed to date magmatic gas loss that is synchronous with volcanic eruption (e.g., Rubin et al. 1994).

  1. Biogeographic Dating of Speciation Times Using Paleogeographically Informed Processes.

    PubMed

    Landis, Michael J

    2017-03-01

    Standard models of molecular evolution cannot estimate absolute speciation times alone, and require external calibrations to do so, such as fossils. Because fossil calibration methods rely on the incomplete fossil record, a great number of nodes in the tree of life cannot be dated precisely. However, many major paleogeographical events are dated, and since biogeographic processes depend on paleogeographical conditions, biogeographic dating may be used as an alternative or complementary method to fossil dating. I demonstrate how a time-stratified biogeographic stochastic process may be used to estimate absolute divergence times by conditioning on dated paleogeographical events. Informed by the current paleogeographical literature, I construct an empirical dispersal graph using 25 areas and 26 epochs for the past 540 Ma of Earth's history. Simulations indicate biogeographic dating performs well so long as paleogeography imposes constraint on biogeographic character evolution. To gauge whether biogeographic dating may be of practical use, I analyzed the well-studied turtle clade (Testudines) to assess how well biogeographic dating fares when compared to fossil-calibrated dating estimates reported in the literature. Fossil-free biogeographic dating estimated the age of the most recent common ancestor of extant turtles to be from the Late Triassic, which is consistent with fossil-based estimates. Dating precision improves further when including a root node fossil calibration. The described model, paleogeographical dispersal graph, and analysis scripts are available for use with RevBayes. © The Author(s) 2016. Published by Oxford University Press, on behalf of the Society of Systematic Biologists. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  2. Genetic diversity of the haemagglutinin (HA) of human influenza a (H1N1) virus in montenegro: Focus on its origin and evolution.

    PubMed

    Mugosa, Boban; Vujosevic, Danijela; Ciccozzi, Massimo; Valli, Maria Beatrice; Capobianchi, Maria Rosaria; Lo Presti, Alessandra; Cella, Eleonora; Giovanetti, Marta; Lai, Alessia; Angeletti, Silvia; Scarpa, Fabio; Terzić, Dragica; Vratnica, Zoran

    2016-11-01

    In 2009 an influenza A epidemic caused by a swine origin H1N1strain, unusual in human hosts, has been described. The present research is aimed to perform the first phylogenetic investigation on the influenza virus A (H1N1) strains circulating in Montenegro, from December 1, 2009, when the first case of death due to H1N1 was confirmed, and the epidemic began causing a total of four fatalities. The phylogenetic analysis of the strains circulating showed the absence of a pure Montenegrin cluster, suggesting the occurrence of multiple re-introductions in that population from different areas till as far as the early 2010. The time to most recent common ancestor (TMRCA) for the complete dataset has been dated in early 2008, pre-dating the first Montenegrin identification of H1N1 infection. These data suggest that virus was spreading undetected, may be as a consequence of unidentified infections in returning travelers. Anyhow, the estimated TMRCA of Montenegrin strains is fully consistent to that found in different areas. Compatibly with the time coverage of the study period here analyzed, molecular dynamic of Montenegrin strains follows similar trend as in other countries. J. Med. Virol. 88:1905-1913, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  3. Transoceanic Dispersal and Plate Tectonics Shaped Global Cockroach Distributions: Evidence from Mitochondrial Phylogenomics.

    PubMed

    Bourguignon, Thomas; Tang, Qian; Ho, Simon Y W; Juna, Frantisek; Wang, Zongqing; Arab, Daej A; Cameron, Stephen L; Walker, James; Rentz, David; Evans, Theodore A; Lo, Nathan

    2018-04-01

    Following the acceptance of plate tectonics theory in the latter half of the 20th century, vicariance became the dominant explanation for the distributions of many plant and animal groups. In recent years, however, molecular-clock analyses have challenged a number of well-accepted hypotheses of vicariance. As a widespread group of insects with a fossil record dating back 300 My, cockroaches provide an ideal model for testing hypotheses of vicariance through plate tectonics versus transoceanic dispersal. However, their evolutionary history remains poorly understood, in part due to unresolved relationships among the nine recognized families. Here, we present a phylogenetic estimate of all extant cockroach families, as well as a timescale for their evolution, based on the complete mitochondrial genomes of 119 cockroach species. Divergence dating analyses indicated that the last common ancestor of all extant cockroaches appeared ∼235 Ma, ∼95 My prior to the appearance of fossils that can be assigned to extant families, and before the breakup of Pangaea began. We reconstructed the geographic ranges of ancestral cockroaches and found tentative support for vicariance through plate tectonics within and between several major lineages. We also found evidence of transoceanic dispersal in lineages found across the Australian, Indo-Malayan, African, and Madagascan regions. Our analyses provide evidence that both vicariance and dispersal have played important roles in shaping the distribution and diversity of these insects.

  4. 76 FR 6555 - Loan Guaranty Revised Loan Modification Procedures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... due date for payments. Modifications usually adjust the terms of the loan agreement by: capitalizing delinquent interest, advances, or other amounts due; extending the repayment terms; changing the interest... guaranteed housing loans in default. Specifically, changes are made to requirements related to maximum...

  5. Investigation assessing the publicly available evidence supporting postmarketing withdrawals, revocations and suspensions of marketing authorisations in the EU since 2012

    PubMed Central

    Lynn, Elizabeth; Shakir, Saad

    2018-01-01

    Objectives To assess the sources of publicly available evidence supporting withdrawal, revocation or suspension of marketing authorisations (‘regulatory actions’) due to safety reasons in the EU since 2012 and to investigate the time taken since initial marketing authorisation to reach these regulatory decisions. Setting This investigation examined the sources of evidence supporting 18 identified prescription medicinal products which underwent regulatory action due to safety reasons within the EU in the period 1 July 2012 to 31 December 2016. Results Eighteen single or combined active substances (‘medicinal products’) withdrawn, revoked or suspended within the EU for safety reasons between 2012 and 2016 met the inclusion criteria. Case reports were most commonly cited, supporting 94.4% of regulatory actions (n=17), followed by randomised controlled trial, meta-analyses, animal and in vitro, ex vivo or in silico study designs, each cited in 72.2% of regulatory actions (n=13). Epidemiological study designs were least commonly cited (n=8, 44.4%). Multiple sources of evidence contributed to 94.4% of regulatory decisions (n=17). Death was the most common adverse drug reaction leading to regulatory action (n=5; 27.8%), with four of these related to medication error or overdose. Median (IQR) time taken to reach a decision from the start of regulatory review was found to be 204.5 days (143, 535 days) and decreased across the study period. Duration of marketing prior to regulatory action, from the medicinal product’s authorisation date, increased across the period 2012–2016. Conclusions The sources of evidence supporting pharmacovigilance regulatory activities appear to have changed since implementation of Directive 2010/84/EU and Regulation (EU) No. 1235/2010. This, together with a small improvement in regulatory efficiency, suggests progress towards more rapid regulatory decisions based on more robust evidence. Future research should continue to monitor sources of evidence supporting regulatory decisions and the time taken to reach these decisions over time. PMID:29362275

  6. A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vrba, Lukas; Garbe, James C.; Stampfer, Martha R.

    Immortality is an essential characteristic of human carcinoma cells. We recently developed an efficient, reproducible method that immortalizes human mammary epithelial cells (HMEC) in the absence of gross genomic changes by targeting 2 critical senescence barriers. Consistent transcriptomic changes associated with immortality were identified using microarray analysis of isogenic normal finite pre-stasis, abnormal finite post-stasis, and immortal HMECs from 4 individuals. A total of 277 genes consistently changed in cells that transitioned from post-stasis to immortal. Gene ontology analysis of affected genes revealed biological processes significantly altered in the immortalization process. These immortalization-associated changes showed striking similarity to the genemore » expression changes seen in The Cancer Genome Atlas (TCGA) clinical breast cancer data. The most dramatic change in gene expression seen during the immortalization step was the downregulation of an unnamed, incompletely annotated transcript that we called MORT, for mortality, since its expression was closely associated with the mortal, finite lifespan phenotype. We show here that MORT (ZNF667-AS1) is expressed in all normal finite lifespan human cells examined to date and is lost in immortalized HMEC. MORT gene silencing at the mortal/immortal boundary was due to DNA hypermethylation of its CpG island promoter. This epigenetic silencing is also seen in human breast cancer cell lines and in a majority of human breast tumor tissues. The functional importance of DNA hypermethylation in MORT gene silencing is supported by the ability of 5-aza-2'- deoxycytidine to reactivate MORT expression. Analysis of TCGA data revealed deregulation of MORT expression due to DNA hypermethylation in 15 out of the 17 most common human cancers. In conclusion, the epigenetic silencing of MORT in a large majority of the common human cancers suggests a potential fundamental role in cellular immortalization during human carcinogenesis.« less

  7. A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers

    DOE PAGES

    Vrba, Lukas; Garbe, James C.; Stampfer, Martha R.; ...

    2015-10-19

    Immortality is an essential characteristic of human carcinoma cells. We recently developed an efficient, reproducible method that immortalizes human mammary epithelial cells (HMEC) in the absence of gross genomic changes by targeting 2 critical senescence barriers. Consistent transcriptomic changes associated with immortality were identified using microarray analysis of isogenic normal finite pre-stasis, abnormal finite post-stasis, and immortal HMECs from 4 individuals. A total of 277 genes consistently changed in cells that transitioned from post-stasis to immortal. Gene ontology analysis of affected genes revealed biological processes significantly altered in the immortalization process. These immortalization-associated changes showed striking similarity to the genemore » expression changes seen in The Cancer Genome Atlas (TCGA) clinical breast cancer data. The most dramatic change in gene expression seen during the immortalization step was the downregulation of an unnamed, incompletely annotated transcript that we called MORT, for mortality, since its expression was closely associated with the mortal, finite lifespan phenotype. We show here that MORT (ZNF667-AS1) is expressed in all normal finite lifespan human cells examined to date and is lost in immortalized HMEC. MORT gene silencing at the mortal/immortal boundary was due to DNA hypermethylation of its CpG island promoter. This epigenetic silencing is also seen in human breast cancer cell lines and in a majority of human breast tumor tissues. The functional importance of DNA hypermethylation in MORT gene silencing is supported by the ability of 5-aza-2'- deoxycytidine to reactivate MORT expression. Analysis of TCGA data revealed deregulation of MORT expression due to DNA hypermethylation in 15 out of the 17 most common human cancers. In conclusion, the epigenetic silencing of MORT in a large majority of the common human cancers suggests a potential fundamental role in cellular immortalization during human carcinogenesis.« less

  8. 77 FR 60976 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-05

    .... Comments Due: 5 p.m. ET 10/10/12. Docket Numbers: RP12-1103-000. Applicants: Dominion Transmission, Inc...: 20120927-5025. Comments Due: 5 p.m. ET 10/9/12. Docket Numbers: RP12-1072-000. Applicants: Golden Triangle... effective 12/1/2012. Filed Date: 9/27/12. Accession Number: 20120927-5032. Comments Due: 5 p.m. ET 10/9/12...

  9. 77 FR 14358 - Combined Notice of Filings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-09

    ...: 3/1/12. Accession Number: 20120301-5204. Comments Due: 5 p.m. ET 3/13/12. Docket Numbers: RP12-467.... Accession Number: 20120301-5078. Comments Due: 5 p.m. ET 3/13/12. Docket Numbers: RP12-451-000. Applicants.../1/2012. Filed Date: 3/1/12. Accession Number: 20120301-5079. Comments Due: 5 p.m. ET 3/13/12. Docket...

  10. 77 FR 20813 - Combined Notice of Filings #2

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-06

    .... Comments Due: 5 p.m. ET 4/20/12. Docket Numbers: ER12-1397-000. Applicants: PJM Interconnection, L.L.C.... Comments Due: 5 p.m. ET 4/10/12. Take notice that the Commission received the following electric rate.../2012. Filed Date: 3/30/12. Accession Number: 20120330-5363. Comments Due: 5 p.m. ET 4/20/12. Docket...

  11. Spatiotemporal Variation in Avian Migration Phenology: Citizen Science Reveals Effects of Climate Change

    PubMed Central

    Hurlbert, Allen H.; Liang, Zhongfei

    2012-01-01

    A growing number of studies have documented shifts in avian migratory phenology in response to climate change, and yet there is a large amount of unexplained variation in the magnitude of those responses across species and geographic regions. We use a database of citizen science bird observations to explore spatiotemporal variation in mean arrival dates across an unprecedented geographic extent for 18 common species in North America over the past decade, relating arrival dates to mean minimum spring temperature. Across all species and geographic locations, species shifted arrival dates 0.8 days earlier for every °C of warming of spring temperature, but it was common for some species in some locations to shift as much as 3–6 days earlier per °C. Species that advanced arrival dates the earliest in response to warming were those that migrate more slowly, short distance migrants, and species with broader climatic niches. These three variables explained 63% of the interspecific variation in phenological response. We also identify a latitudinal gradient in the average strength of phenological response, with species shifting arrival earlier at southern latitudes than northern latitudes for the same degree of warming. This observation is consistent with the idea that species must be more phenologically sensitive in less seasonal environments to maintain the same degree of precision in phenological timing. PMID:22384050

  12. Targeting Common but Complex Proteoglycans on Breast Cancer Cells and Stem Cells Using Evolutionary Refined Malaria Proteins

    DTIC Science & Technology

    2015-11-01

    AWARD NUMBER: W81XWH-13-1-0139 TITLE: Targeting Common but Complex Proteoglycans on Breast Cancer Cells and Stem Cells Using Evolutionary Refined...DATES COVERED 15Aug2013 - 14Aug2015 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER W81XWH-13-1-0139 Targeting Common but Complex Proteoglycans on...outbreaks in epidemic regions of the world. Prior to this application we discovered that human breast cancer cells express this same carbohydrate

  13. Exploring the relationship between child physical abuse and adult dating violence using a causal inference approach in an emerging adult population in South Korea.

    PubMed

    Jennings, Wesley G; Park, MiRang; Richards, Tara N; Tomsich, Elizabeth; Gover, Angela; Powers, Ráchael A

    2014-12-01

    Child maltreatment is one of the most commonly examined risk factors for violence in dating relationships. Often referred to as the intergenerational transmission of violence or cycle of violence, a fair amount of research suggests that experiencing abuse during childhood significantly increases the likelihood of involvement in violent relationships later, but these conclusions are primarily based on correlational research designs. Furthermore, the majority of research linking childhood maltreatment and dating violence has focused on samples of young people from the United States. Considering these limitations, the current study uses a rigorous, propensity score matching approach to estimate the causal effect of experiencing child physical abuse on adult dating violence among a large sample of South Korean emerging adults. Results indicate that the link between child physical abuse and adult dating violence is spurious rather than causal. Study limitations and implications are discussed. Copyright © 2014 Elsevier Ltd. All rights reserved.

  14. The influence of storage duration on the setting time of type 1 alginate impression material

    NASA Astrophysics Data System (ADS)

    Rahmadina, A.; Triaminingsih, S.; Irawan, B.

    2017-08-01

    Alginate is one of the most commonly used dental impression materials; however, its setting time is subject to change depending on storage conditions and duration. This creates problems because consumer carelessness can affect alginate shelf life and quality. In the present study, the setting times of two groups of type I alginate with different expiry dates was tested. The first group consisted of 11 alginate specimens that had not yet passed the expiry date, and the second group consisted of alginates that had passed the expiry date. The alginate powder was mixed with distilled water, poured into a metal ring, and tested with a polished rod of poly-methyl methacrylate. Statistical analysis showed a significant difference (p<0.05) between the setting times of the alginate that had not passed the expiry date (157 ± 3 seconds) and alginate that had passed the expiry date (144 ± 2 seconds). These findings indicate that storage duration can affect alginate setting time.

  15. Investigation of the irradiation history of the Iranian dates and pistachio nuts using thermoluminescence technique

    NASA Astrophysics Data System (ADS)

    Sharifzadeh, M.; Sohrabpour, M.

    1993-07-01

    Three different varieties of Iranian fresh dates and five types of raw and salted pistachio nuts have been tested for identification of irradiation histories. Doses of 2.5, 5, 7.5 and 10 kGy from a gamma cell Gc-220 have been administrated to the samples under investigation. TL response versus dose for date and for pistachio nuts have been obtained. The effect of added ingredients such as salt in pistachio nuts, and moisture in date samples on the TL response have been studied. The fading of TL intensity of the irradiated dates and pistachio nuts have also been measured. Based on the latter results, it appears possible to identify the irradiated dates (10 kGy), within (1-2) months post-irradiation. In the salted pistachio nuts, the salt itself gives a very significant and distinguishable response. In the unsalted case, however, the difference between the irradiated and unirradiated samples seem difficult to detect due to partial overlapping of the respective responses.

  16. 38 CFR 76.3 - Application and certification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... provide certification of the veteran's participation in training or competition sponsored by the USP or... certification must specify whether the payment is due for training, competition, or residence, and the dates of the training, competition, or residence for which payment is due. The Office of Management and Budget...

  17. 7 CFR 1951.223 - Reamortization.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... delinquent amount. Accrued interest will be at the rate currently reflected in Finance Office records. (1... government's interest will remain adequately protected if the security position will be affected. (3) Notes...; and (E) The interest rate. (iii) A payment will be due on the next scheduled due date. Deferment of...

  18. 78 FR 1276 - FY 2012 Annual Compliance Report

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... POSTAL REGULATORY COMMISSION [Docket No. ACR2012; Order No. 1609] FY 2012 Annual Compliance Report... Compliance Report on the costs, revenues, rates, and quality of service associated with its products in... Compliance Report. DATES: Comments are due: February 1, 2013. Reply Comments are due: February 15, 2013...

  19. Is 137Cs Dating Becoming Obsolete in North America?

    NASA Astrophysics Data System (ADS)

    Drexler, J. Z.; Fuller, C.; Salas, A.

    2016-12-01

    Dating of wetland sediments and peat is routinely carried out using 137Cs and 210Pb analysis. Unlike 210Pb, 137Cs is an anthropogenic radionuclide with a history of fallout from nuclear weapons testing. 137Cs is used as a single time marker; its peak is coincident with the height of atmospheric nuclear testing in 1963/4. During its use in the 1970s-90s, 137Cs peaks were usually highly distinct in wetland sediments (e.g., see 137Cs peaks from Louisiana marshes in Feijtel et al., 1988). This enabled its use as a check for dates assigned to a profile by 210Pb and other methods. However, recently, the efficacy of 137Cs dating in North America has deteriorated. In this presentation, we will provide specific examples of 137Cs as well as 210Pb dating in wetland sediments/peats we collected between 2005 and 2015 in Maine, California, Virginia, North Carolina, South Carolina, and Washington. Two main reasons exist for this decline. First, 137Cs activities in our recent cores are 30-40 % of the original activities in 1963/4 due to decay of the original 137Cs in situ (half-life = 30.17 years) and no major new sources. This manifests in lower signal to noise ratio, with some peaks barely recognizable above the noise. Second, 137Cs peaks are much less distinct due to 137Cs migration through time independent of substrate (or sediment) particles. Migration of peaks has resulted in estimated accretion rates being systematically lower or higher than those derived from 210Pb dating. These issues with 137Cs dating have important implications because 137Cs is used with 210Pb dating or even alone to determine rates of recent wetland carbon accumulation. Such rates are required to enter wetland restoration projects into carbon markets and to document IPCC mandated reductions in carbon pollution. Our analysis shows that, although dating by 137Cs alone has always been highly tenuous, now it is especially contraindicated and should be disallowed for the purposes of carbon accounting.

  20. Clinical Investigation Program Report.

    DTIC Science & Technology

    1983-10-01

    metastatic to liver. (0) H-83-63. Double-blind, randomized parallel comparison of two different dosage regimens of naproxen sodium in patients with...different dosage regimens of naproxen sodium in patients with bone pain due to m etastatic cancer. Start Date: May 83 Est Comp Date: Indefinite Principal...Investigator: Facility: LTC D Gandara, MD LAMC CPT R Mansour, MD D ept/Svc: Associate Investigators: Hematology-Oncology Key Words: naproxen sodium

  1. 75 FR 3488 - Notice of Public Meetings for the National Park Service Alaska Region's Subsistence Resource...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ... scheduled at the call of the Chair. Should this meeting be postponed due to inclement weather or lack of a... inclement weather, or lack of a quorum, the alternate meeting dates are Saturday, March 6, 2010, from 7 p.m... meeting locations and dates may need to be changed based on lack of quorum, inclement weather or local...

  2. Dezhurov works with electronic equipment in Zvezda during Expedition Three

    NASA Image and Video Library

    2001-08-01

    ISS003-E-5486 (August 2001) --- Cosmonaut Vladimir Dezhurov of Rosaviakosmos, Expedition Three flight engineer, works on electronic equipment behind a panel in the Zvezda Service Module. Please note: The date identifiers on some frames are not accurate due to a technical problem with one of the Expedition Three cameras. When a specific date is given in the text or description portion, it is correct.

  3. Dezhurov works with electronic equipment in Zvezda during Expedition Three

    NASA Image and Video Library

    2001-08-01

    ISS003-E-5489 (August 2001) --- Cosmonaut Vladimir Dezhurov of Rosaviakosmos, Expedition Three flight engineer, works on electronic equipment behind a panel in the Zvezda Service Module. Please note: The date identifiers on some frames are not accurate due to a technical problem with one of the Expedition Three cameras. When a specific date is given in the text or description portion, it is correct.

  4. Luminescence quartz dating of lime mortars. A first research approach.

    PubMed

    Zacharias, N; Mauz, B; Michael, C T

    2002-01-01

    Lime mortars mixed with sand are well suited for connecting structural materials, like stones and bricks, due to the mechanical properties this material exhibits. Their extensive use in architectural and decorative works during the last 4000 years motivated the introduction of the 'Luminescence clock' for age determination of mortars. The same principles as for quartz optically stimulated luminescence (OSL) dating of sediments were applied for age estimation of a mortar fragment removed from a Byzantine church monument dated by archaeological means to 1050-1100 years ago (the first half of the 10th century). The OSL from the quartz was monitored under blue light stimulation and UV detection, using a single-aliquot-regenerative-dose protocol. The quartz-OSL dating of the mortar resulted in 870 +/- 230 a. TL polymineral fine grain dating was also performed on a brick fragment which was connected to the mortar, resulting in a TL age of 1095 +/- 190 a.

  5. Winter precipitation effect in a mid-latitude temperature-limited environment: the case of common juniper at high elevation in the Alps

    NASA Astrophysics Data System (ADS)

    Pellizzari, Elena; Pividori, Mario; Carrer, Marco

    2014-10-01

    Common juniper (Juniperus communis L.) is by far the most widespread conifer in the world. However, tree-ring research dealing with this species is still scarce, mainly due to the difficulty in crossdating associated with the irregular stem shape with strip-bark growth form in older individuals and the high number of missing and wedging rings. Given that many different species of the same genus have been successfully used in tree-ring investigations and proved to be reliable climate proxies, this study aims to (i) test the possibility to successfully apply dendrochronological techniques on common juniper growing above the treeline and (ii) verify the climate sensitivity of the species with special regard to winter precipitation, a climatic factor that generally does not affect tree-ring growth in all Alpine high-elevation tree species. Almost 90 samples have been collected in three sites in the central and eastern Alps, all between 2100 and 2400 m in elevation. Despite cross-dating difficulties, we were able to build a reliable chronology for each site, each spanning over 200 years. Climate-growth relationships computed over the last century highlight that juniper growth is mainly controlled by the amount of winter precipitation. The high variability of the climate-growth associations among sites, corresponds well to the low spatial dependence of this meteorological factor. Fairly long chronologies and the presence of a significant precipitation signal open up the possibility to reconstruct past winter precipitation.

  6. Evolutionary stability in continuous nonlinear public goods games.

    PubMed

    Molina, Chai; Earn, David J D

    2017-01-01

    We investigate a type of public goods games played in groups of individuals who choose how much to contribute towards the production of a common good, at a cost to themselves. In these games, the common good is produced based on the sum of contributions from all group members, then equally distributed among them. In applications, the dependence of the common good on the total contribution is often nonlinear (e.g., exhibiting synergy or diminishing returns). To date, most theoretical and experimental studies have addressed scenarios in which the set of possible contributions is discrete. However, in many real-world situations, contributions are continuous (e.g., individuals volunteering their time). The "n-player snowdrift games" that we analyze involve continuously varying contributions. We establish under what conditions populations of contributing (or "cooperating") individuals can evolve and persist. Previous work on snowdrift games, using adaptive dynamics, has found that what we term an "equally cooperative" strategy is locally convergently and evolutionarily stable. Using static evolutionary game theory, we find conditions under which this strategy is actually globally evolutionarily stable. All these results refer to stability to invasion by a single mutant. We broaden the scope of existing stability results by showing that the equally cooperative strategy is locally stable to potentially large population perturbations, i.e., allowing for the possibility that mutants make up a non-negligible proportion of the population (due, for example, to genetic drift, environmental variability or dispersal).

  7. Detection of Ophiocordyceps sinensis and Its Common Adulterates Using Species-Specific Primers

    PubMed Central

    Liu, Yang; Wang, Xiao-yue; Gao, Zi-tong; Han, Jian-ping; Xiang, Li

    2017-01-01

    Ophiocordyceps sinensis is a fungus that infects Hepialidae caterpillars, mummifying the larvae and producing characteristic fruiting bodies (stromata) that are processed into one of the most valued traditional Chinese medicines (TCM). The product commands a very high price due to a high demand but a very limited supply. Adulteration with other fungi is a common problem and there is a need to test preparation for the presence of the correct fungus. In the current study, a PCR-based approach for the identification of O. sinensis based on a segment of the internal transcribed spacer (ITS) region was developed. The segments is 146-bp in size and is likely to be amplified even in materials where processing led to DNA fragmentation. Primer development was based on the alignment of sequence data generated from a total of 89 samples of O. sinensis and potential adulterants as well as sequences date from 41 Ophiocordyceps species and 26 Cordyceps species available in GenBank. Tests with primer pair, DCF4/DCR4, demonstrated generation of an amplicon from DNA extracted from O. sinensis stromata, but not from extracts derived from adulterants. Species-specific primer pairs were also developed and tested for detection of the common adulterants, Cordyceps gunnii, Cordyceps cicadae, Cordyceps militaris, Cordyceps liangshanensis and Ophiocordyceps nutans. The collection of primers developed in the present study will be useful for the authentication of preparation claiming to only contain O. sinensis and for the detection of fungi used as adulterants in these preparations. PMID:28680424

  8. Modeling stimulus variation in three common implicit attitude tasks.

    PubMed

    Wolsiefer, Katie; Westfall, Jacob; Judd, Charles M

    2017-08-01

    We explored the consequences of ignoring the sampling variation due to stimuli in the domain of implicit attitudes. A large literature in psycholinguistics has examined the statistical treatment of random stimulus materials, but the recommendations from this literature have not been applied to the social psychological literature on implicit attitudes. This is partly because of inherent complications in applying crossed random-effect models to some of the most common implicit attitude tasks, and partly because no work to date has demonstrated that random stimulus variation is in fact consequential in implicit attitude measurement. We addressed this problem by laying out statistically appropriate and practically feasible crossed random-effect models for three of the most commonly used implicit attitude measures-the Implicit Association Test, affect misattribution procedure, and evaluative priming task-and then applying these models to large datasets (average N = 3,206) that assess participants' implicit attitudes toward race, politics, and self-esteem. We showed that the test statistics from the traditional analyses are substantially (about 60 %) inflated relative to the more-appropriate analyses that incorporate stimulus variation. Because all three tasks used the same stimulus words and faces, we could also meaningfully compare the relative contributions of stimulus variation across the tasks. In an appendix, we give syntax in R, SAS, and SPSS for fitting the recommended crossed random-effects models to data from all three tasks, as well as instructions on how to structure the data file.

  9. Matrix effects for elemental fractionation within ICPMS: applications for U-Th-Pb geochronology

    NASA Astrophysics Data System (ADS)

    Chen, W.

    2016-12-01

    Recent development in instruments provides significant technical supports for daily, quick, money saving geochemical analyses. Laser ablation ICPMS stands out due to these reasons, especially for the U-Th-Pb isotopic dating. Matrix-matched external standardization is by far the most common approach used in U-Th-Pb dating via LA-ICPMS. However, matrix-effects between standard and sample for in-situ dating have shown to be both significant and insignificant. It remains mysterious whether a well matrix-matched standard is needed for U-Th-Pb dating by LA-ICPMS. This study provides an experimental framework for the understanding of matrix effects induced elemental fractionation for U-Th-Pb associated with ICPMS. A preliminary study on the influence of varied U, Th and Pb amounts on their fractionations has been carried out. Experimental data show that different U, Th and Pb contents result in varied 238U/206Pb and 232Th/208Pb ratios. The fractionations of U/Pb and Th/Pb increase with the increasing contents (1 ppb to 100 ppb) with a strong positive anomaly at 10 ppb. Matrixes representing minerals frequently used in dating have been investigated for the influences on U/Pb and Th/Pb fractionations, which suggest a complicated effect. Little fractionations observed between mineral pairs (e.g., monazite and apatite; zircon and perovskite; rutile and perovskite; xenotime and baddeleyite), whereas large fractionations identified for other minerals (e.g., zircon and baddeleyite; monazite and sphene; rutile and baddeleyite). Single element matrix (i.e., Si, P, Ca, Zr, Ti) has been studied to identify their effects on the fractionations. U/Pb ratio increases with the increasing Si and P contents, whereas it decreases for Zr, Ca and Ti. Th/Pb ratio increases with increasing Si contents, decreases for P and Zr, and increases first then decreases for Ca and Ti. Above all, different matrix and U, Th and Pb amounts show distinct U/Pb and Th/Pb fractionations within ICPMS. The minerals with matrix indicating similar fractionations in ICPMS can be used as suitable reference standards for each other with proper laser ablation settings via LA-ICPMS. Moreover, matched U, Th and Pb contents should be considered when using a matrix-matched standard in laser ablation analysis.

  10. Chemical abrasion-SIMS (CA-SIMS) U-Pb dating of zircon from the late Eocene Caetano caldera, Nevada

    USGS Publications Warehouse

    Watts, Kathryn E.; Coble, Matthew A.; Vazquez, Jorge A.; Henry, Christopher D.; Colgan, Joseph P.; John, David A.

    2016-01-01

    Zircon geochronology is a critical tool for establishing geologic ages and time scales of processes in the Earth's crust. However, for zircons compromised by open system behavior, achieving robust dates can be difficult. Chemical abrasion (CA) is a routine step prior to thermal ionization mass spectrometry (TIMS) dating of zircon to remove radiation-damaged parts of grains that may have experienced open system behavior and loss of radiogenic Pb. While this technique has been shown to improve the accuracy and precision of TIMS dating, its application to high-spatial resolution dating methods, such as secondary ion mass spectrometry (SIMS), is relatively uncommon. In our efforts to U-Pb date zircons from the late Eocene Caetano caldera by SIMS (SHRIMP-RG: sensitive high resolution ion microprobe, reverse geometry), some grains yielded anomalously young U-Pb ages that implicated Pb-loss and motivated us to investigate with a comparative CA and non-CA dating study. We present CA and non-CA 206Pb/238U ages and trace elements determined by SHRIMP-RG for zircons from three Caetano samples (Caetano Tuff, Redrock Canyon porphyry, and a silicic ring-fracture intrusion) and for R33 and TEMORA-2 reference zircons. We find that non-CA Caetano zircons have weighted mean or bimodal U-Pb ages that are 2–4% younger than CA zircons for the same samples. CA Caetano zircons have mean U-Pb ages that are 0.4–0.6 Myr older than the 40Ar/39Ar sanidine eruption age (34.00 ± 0.03 Ma; error-weighted mean, 2σ), whereas non-CA zircons have ages that are 0.7–1.3 Myr younger. U-Pb ages do not correlate with U (~ 100–800 ppm), Th (~ 50–300 ppm) or any other measured zircon trace elements (Y, Hf, REE), and CA and non-CA Caetano zircons define identical trace element ranges. No statistically significant difference in U-Pb age is observed for CA versus non-CA R33 or TEMORA-2 zircons. Optical profiler measurements of ion microprobe pits demonstrate consistent depths of ~ 1.6 μm for CA and non-CA Caetano, R33 and TEMORA-2 zircons, and do not indicate variations in secondary ion sputtering rates due to chemical or structural changes from the CA treatment. Our new data underscore the potential for cryptic Pb-loss to go unrecognized in other geologically young magmatic centers that do not have zircons with high U, statistically discordant isotope ratios, high common Pb, or metamict textures.

  11. Journalists’ Privilege: Overview of the Law and 109th Congress Legislation

    DTIC Science & Technology

    2006-10-03

    control number. 1. REPORT DATE 03 OCT 2006 2. REPORT TYPE N/A 3. DATES COVERED - 4. TITLE AND SUBTITLE Journalists Privilege: Overview of the...City of New York, The Federal Common Law of Journalists ’ Privilege: A Position Paper (2005) at 4-5 [http://www.abcny.org/pdf/ report /White%20paper...706. 10 These statutes are set forth in CRS Report RL32806, Journalists ’ Privilege to Withhold Information in Judicial and Other Proceedings: State

  12. Flightless birds: when did the dodo become extinct?

    PubMed

    Roberts, David L; Solow, Andrew R

    2003-11-20

    The extinction of the dodo (Raphus cucullatus L.; Fig. 1) is commonly dated to the last confirmed sighting in 1662, reported by Volkert Evertsz on an islet off Mauritius. By this time, the dodo had become extremely rare - the previous sighting having been 24 years earlier - but the species probably persisted unseen beyond this date. Here we use a statistical method to establish the actual extinction time of the dodo as 1690, almost 30 years after its most recent sighting.

  13. Flightless birds: When did the dodo become extinct?

    NASA Astrophysics Data System (ADS)

    Roberts, David L.; Solow, Andrew R.

    2003-11-01

    The extinction of the dodo (Raphus cucullatus L.; Fig. 1) is commonly dated to the last confirmed sighting in 1662, reported by Volkert Evertsz on an islet off Mauritius. By this time, the dodo had become extremely rare - the previous sighting having been 24 years earlier - but the species probably persisted unseen beyond this date. Here we use a statistical method to establish the actual extinction time of the dodo as 1690, almost 30 years after its most recent sighting.

  14. 78 FR 35072 - Proposed Revision to Strategies and Guidance to Address Loss of Large Areas of the Plant Due to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-11

    ... Address Loss of Large Areas of the Plant Due to Explosions and Fires AGENCY: Nuclear Regulatory Commission... Standard Review Plan (SRP), Section 19.4 ``Strategies and Guidance to Address Loss of Large Areas of the... review of the subject of loss-of-large areas of the plant due to explosions and fires. DATES: Submit...

  15. 78 FR 23760 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-22

    ... that the Commission received the following electric corporate filings: Docket Numbers: EC13-90-000...: 20130411-5136. Comments Due: 5 p.m. ET 5/2/13. Docket Numbers: EC13-91-000. Applicants: Florida Power... of Florida Power & Light Company. Filed Date: 4/12/13. Accession Number: 20130412-5169. Comments Due...

  16. 40 CFR 65.5 - Reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... comply with this part, and who are not operating the regulated source under an approved title V permit... submitted as part of a title V permit application or amendment. (2) Due date. The owner or operator shall... after the Initial Compliance Status Report is due. (3) Overlap with title V reports. Information...

  17. 78 FR 38708 - Combined Notice of Filings #1

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-27

    ...-5061. Comments Due: 5 p.m. ET 6/27/13. Docket Numbers: EC13-119-000. Applicants: Longview Fibre Paper... Longview Fibre Paper and Packaging, Inc. Filed Date: 6/14/13. Accession Number: 20130614-5190. Comments Due... Independent System Operator, Inc. Description: Midcontinent Independent System Operator, Inc. submits 06-14...

  18. 7 CFR 1412.1 - Applicability, statutory changes, interest, and contract provisions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., oats, upland cotton, rice, peanuts, soybeans, sunflower seed, rapeseed, canola, safflower, flaxseed, mustard seed, crambe, sesame seed, pulse crops, and other designated oilseeds as determined and announced... contract. Also, if any refund comes due to CCC under this part, interest will be due from the date of the...

  19. 7 CFR 1412.1 - Applicability, statutory changes, interest, and contract provisions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., oats, upland cotton, rice, peanuts, soybeans, sunflower seed, rapeseed, canola, safflower, flaxseed, mustard seed, crambe, sesame seed, pulse crops, and other designated oilseeds as determined and announced... contract. Also, if any refund comes due to CCC under this part, interest will be due from the date of the...

  20. 7 CFR 1412.1 - Applicability, statutory changes, interest, and contract provisions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., oats, upland cotton, rice, peanuts, soybeans, sunflower seed, rapeseed, canola, safflower, flaxseed, mustard seed, crambe, sesame seed, pulse crops, and other designated oilseeds as determined and announced... contract. Also, if any refund comes due to CCC under this part, interest will be due from the date of the...

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