Observations of Exoplanets with the Stratospheric Observatory for Infrared Astronomy (SOFIA)

NASA Astrophysics Data System (ADS)

Gehrz, R.; Becklin, E.

2010-10-01

The joint U.S. and German Stratospheric Observatory for Infrared Astronomy (SOFIA) is a 2.5-meter infrared airborne telescope in a Boeing 747-SP that will begin science flights in 2010. Flying in the stratosphere at altitudes as high as 45,000 feet, SOFIA will be used to conduct photometric, spectroscopic, and imaging observations at wavelengths from 0.3 microns to 1.9 millimeters with an average transmission of greater than 80 percent. SOFIA's first-generation instrument complement includes high speed photometers, broadband imagers, moderate resolution spectrographs capable of resolving broad features due to dust and large molecules, and high resolution spectrometers suitable for kinematic studies of molecular and atomic gas lines at km/s resolution. These and future instruments will give SOFIA the potential to make unique contributions to the characterization of the atmospheres of exoplanets that transit their parent stars. First-light images obtained on May 26, 2010 with the FORCAST imager will be shown. We will discuss several types of experiments that are being contemplated with respect to observations of exoplanets .

The Stratospheric Observatory for Infrared Astronomy (sofia)

NASA Astrophysics Data System (ADS)

Gehrz, R. D.; Becklin, E. E.

2012-06-01

The joint U.S. and German Stratospheric Observatory for Infrared Astronomy (SOFIA) is a 2.5- meter infrared airborne telescope in a Boeing 747-SP. SOFIA can conduct photometric, spectroscopic, and imaging observations at wavelengths from 0.3 microns to 1.6 millimeters. At SOFIA's maximum service ceiling of 45,000 feet, the average transmission at these wavelengths is greater than 80 percent. SOFIA flys out of the NASA Dryden Flight Research Center aircraft operations facility at Palmdale, CA and the SOFIA Science Mission Operations (SMO) Center is located at NASA Ames Research Center, Moffett Field, CA. SOFIA's first-generation instrument complement includes broadband imagers and spectrographs that can resolve spectral features due to dust and large molecules, and high resolution spectrometers facilitating kinematic studies of molecular and atomic gas lines at km/s resolution. More than 30 science flights of 10 hours length (take-off to landing) were conducted in the past year. About 100 eight to ten hour flights per year are planned by 2014, and the observatory will operate until the mid-2030's.

Broadband pulsed flow using piezoelectric microjets

NASA Astrophysics Data System (ADS)

Hogue, Joshua; Solomon, John; Hays, Michael; Alvi, Farrukh; Oates, William

2010-04-01

A piezohydraulic microjet design and experimental results are presented to demonstrate broadband active flow control for applications on various aircraft structures including impinging jets, rotor blades, cavity bays, etc. The microjet actuator includes a piezoelectric stack actuator and hydraulic circuit that is used to throttle a 400 μm diameter microjet using hydraulic amplification of the piezoelectric stack actuator. This system is shown to provide broadband pulsed flow actuation up to 800 Hz. Unsteady pressure measurements of the microjet's exit flow are coupled with high-speed phase imagery using micro-Schlieren techniques to quantify the flow field. These results are compared with in situ stack actuator displacements using strain gauge measurements.

Making structured metals transparent for ultrabroadband electromagnetic waves and acoustic waves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fan, Ren-Hao; Peng, Ru-Wen, E-mail: rwpeng@nju.edu.cn; Huang, Xian-Rong

2015-07-15

In this review, we present our recent work on making structured metals transparent for broadband electromagnetic waves and acoustic waves via excitation of surface waves. First, we theoretically show that one-dimensional metallic gratings can become transparent and completely antireflective for extremely broadband electromagnetic waves by relying on surface plasmons or spoof surface plasmons. Second, we experimentally demonstrate that metallic gratings with narrow slits are highly transparent for broadband terahertz waves at oblique incidence and high transmission efficiency is insensitive to the metal thickness. Further, we significantly develop oblique metal gratings transparent for broadband electromagnetic waves (including optical waves and terahertzmore » ones) under normal incidence. In the third, we find the principles of broadband transparency for structured metals can be extended from one-dimensional metallic gratings to two-dimensional cases. Moreover, similar phenomena are found in sonic artificially metallic structures, which present the transparency for broadband acoustic waves. These investigations provide guidelines to develop many novel materials and devices, such as transparent conducting panels, antireflective solar cells, and other broadband metamaterials and stealth technologies. - Highlights: • Making structured metals transparent for ultrabroadband electromagnetic waves. • Non-resonant excitation of surface plasmons or spoof surface plasmons. • Sonic artificially metallic structures transparent for broadband acoustic waves.« less

Proceedings of the Antenna Applications Symposium (1988) Volume 1

DTIC Science & Technology

1989-06-01

FIELD GROUP SUB-GROUP Antennas)p Microstrip, ,.Multibeam Antennas 6 Satellite Antennas. Reflector Array Antennas, ____________I____ Broadband Antennas...C. Sullivan and G. E. Evans 8. " Broadband MMIC T/R Module/Subarray Performance," D. Brubaker, 157 D. Scott, S. Ludvik, M. Lynch, H. II. Chung, W...34 S. Sanzgiri, 277 B. Powers, Jr., and J. Hart ib. " broadbanding Techniques for Microstrip Patch Antennas - A ’.93 kReview," K. C. Gupta * NUT INCLUDED

Smoke over haze: Comparative analysis of satellite, surface radiometer, and airborne in situ measurements of aerosol optical properties and radiative forcing over the eastern United States

NASA Astrophysics Data System (ADS)

Vant-Hull, Brian; Li, Zhanqing; Taubman, Brett F.; Levy, Robert; Marufu, Lackson; Chang, Fu-Lung; Doddridge, Bruce G.; Dickerson, Russell R.

2005-05-01

In July 2002 Canadian forest fires produced a major smoke episode that blanketed the east coast of the United States. Properties of the smoke aerosol were measured in situ from aircraft, complementing operational Aerosol Robotic Network (AERONET), and Moderate Resolution Imaging Spectroradiometer (MODIS) remotely sensed aerosol retrievals. This study compares single scattering albedo and phase function derived from the in situ measurements and AERONET retrievals in order to evaluate their consistency for application to satellite retrievals of optical depth and radiative forcing. These optical properties were combined with MODIS reflectance observations to calculate optical depth. The use of AERONET optical properties yielded optical depths 2-16% lower than those directly measured by AERONET. The use of in situ-derived optical properties resulted in optical depths 22-43% higher than AERONET measurements. These higher optical depths are attributed primarily to the higher absorption measured in situ, which is roughly twice that retrieved by AERONET. The resulting satellite retrieved optical depths were in turn used to calculate integrated radiative forcing at both the surface and top of atmosphere. Comparisons to surface (Surface Radiation Budget Network (SURFRAD) and ISIS) and to satellite (Clouds and Earth Radiant Energy System CERES) broadband radiometer measurements demonstrate that the use of optical properties derived from the aircraft measurements provided a better broadband forcing estimate (21% error) than those derived from AERONET (33% error). Thus AERONET-derived optical properties produced better fits to optical depth measurements, while in situ properties resulted in better fits to forcing measurements. These apparent inconsistencies underline the significant challenges facing the aerosol community in achieving column closure between narrow and broadband measurements and calculations.

Sweetwater, Texas Large N Experiment

NASA Astrophysics Data System (ADS)

Sumy, D. F.; Woodward, R.; Barklage, M.; Hollis, D.; Spriggs, N.; Gridley, J. M.; Parker, T.

2015-12-01

From 7 March to 30 April 2014, NodalSeismic, Nanometrics, and IRIS PASSCAL conducted a collaborative, spatially-dense seismic survey with several thousand nodal short-period geophones complemented by a backbone array of broadband sensors near Sweetwater, Texas. This pilot project demonstrates the efficacy of industry and academic partnerships, and leveraged a larger, commercial 3D survey to collect passive source seismic recordings to image the subsurface. This innovative deployment of a large-N mixed-mode array allows industry to explore array geometries and investigate the value of broadband recordings, while affording academics a dense wavefield imaging capability and an operational model for high volume instrument deployment. The broadband array consists of 25 continuously-recording stations from IRIS PASSCAL and Nanometrics, with an array design that maximized recording of horizontal-traveling seismic energy for surface wave analysis over the primary target area with sufficient offset for imaging objectives at depth. In addition, 2639 FairfieldNodal Zland nodes from NodalSeismic were deployed in three sub-arrays: the outlier, backbone, and active source arrays. The backbone array consisted of 292 nodes that covered the entire survey area, while the outlier array consisted of 25 continuously-recording nodes distributed at a ~3 km distance away from the survey perimeter. Both the backbone and outlier array provide valuable constraints for the passive source portion of the analysis. This project serves as a learning platform to develop best practices in the support of large-N arrays with joint industry and academic expertise. Here we investigate lessons learned from a facility perspective, and present examples of data from the various sensors and array geometries. We will explore first-order results from local and teleseismic earthquakes, and show visualizations of the data across the array. Data are archived at the IRIS DMC under stations codes XB and 1B.

Polymeric Packaging for Fully Implantable Wireless Neural Microsensors

PubMed Central

Aceros, Juan; Yin, Ming; Borton, David A.; Patterson, William R.; Bull, Christopher; Nurmikko, Arto V.

2014-01-01

We present polymeric packaging methods used for subcutaneous, fully implantable, broadband, and wireless neurosensors. A new tool for accelerated testing and characterization of biocompatible polymeric packaging materials and processes is described along with specialized test units to simulate our fully implantable neurosensor components, materials and fabrication processes. A brief description of the implantable systems is presented along with their current encapsulation methods based on polydimethylsiloxane (PDMS). Results from in-vivo testing of multiple implanted neurosensors in swine and non-human primates are presented. Finally, a novel augmenting polymer thin film material to complement the currently employed PDMS is introduced. This thin layer coating material is based on the Plasma Enhanced Chemical Vapor Deposition (PECVD) process of Hexamethyldisiloxane (HMDSO) and Oxygen (O2). PMID:23365999

STS-3/OSS-1 Plasma Diagnostics Package (PDP) measurements of Orbiter transmitter and subsystem electromagnetic interference

NASA Technical Reports Server (NTRS)

Shawhan, S. D.; Murphy, G.

1983-01-01

The plasma diagnostics package receiver system is described to identify the various antennas and to characterize the complement of receivers which cover the frequency range of 30 Hz to 800 Hz and S-band at 2200 + or - 300 MHz. Sample results are presented to show the variability of electromagnetic effects associated with the orbiter and the time variability of these effects. The electric field and magnetic field maximum and minimum field strength spectra observed during the mission at the pallet location are plotted. Values are also derived for the maximum UHF transmitter and S-band transmitter field strengths. Calibration data to convert from the survey plots to actual narrowband and broadband field strengths are listed.

Statistically Based Approach to Broadband Liner Design and Assessment

NASA Technical Reports Server (NTRS)

Jones, Michael G. (Inventor); Nark, Douglas M. (Inventor)

2016-01-01

A broadband liner design optimization includes utilizing in-duct attenuation predictions with a statistical fan source model to obtain optimum impedance spectra over a number of flow conditions for one or more liner locations in a bypass duct. The predicted optimum impedance information is then used with acoustic liner modeling tools to design liners having impedance spectra that most closely match the predicted optimum values. Design selection is based on an acceptance criterion that provides the ability to apply increasing weighting to specific frequencies and/or operating conditions. One or more broadband design approaches are utilized to produce a broadband liner that targets a full range of frequencies and operating conditions.

Broadband radiometer

DOEpatents

Cannon, Theodore W.

1994-01-01

A broadband radiometer including (a) an optical integrating sphere having a enerally spherical integrating chamber and an entry port for receiving light (e.g., having visible and ultraviolet fractions), (b) a first optical radiation detector for receiving light from the sphere and producing an electrical output signal corresponding to broadband radiation, (c) a second optical radiation detector for receiving light from the sphere and producing an electrical output signal corresponding to a predetermined wavelength fraction of the broadband radiation, and (d) an output for producing an electrical signal which is proportional to the difference between the two electrical output signals. The radiometer is very useful, for example, in measuring the absolute amount of ultraviolet light present in a given light sample.

Broadband radiometer

DOEpatents

Cannon, T.W.

1994-07-26

A broadband radiometer is disclosed including (a) an optical integrating sphere having generally spherical integrating chamber and an entry port for receiving light (e.g., having visible and ultraviolet fractions), (b) a first optical radiation detector for receiving light from the sphere and producing an electrical output signal corresponding to broadband radiation, (c) a second optical radiation detector for receiving light from the sphere and producing an electrical output signal corresponding to a predetermined wavelength fraction of the broadband radiation, and (d) an output for producing an electrical signal which is proportional to the difference between the two electrical output signals. The radiometer is very useful, for example, in measuring the absolute amount of ultraviolet light present in a given light sample. 8 figs.

On the Analysis of Wind-Induced Noise in Seismological Recordings

NASA Astrophysics Data System (ADS)

Lott, Friederike F.; Ritter, Joachim R. R.; Al-Qaryouti, Mahmoud; Corsmeier, Ulrich

2017-03-01

Atmospheric processes, ranging from microscale turbulence to severe storms on the synoptic scale, impact the continuous ground motion of the earth and have the potential to induce strong broad-band noise in seismological recordings. We designed a target-oriented experiment to quantify the influence of wind on ground motion velocity in the Dead Sea valley. For the period from March 2014 to February 2015, a seismological array, consisting of 15 three-component short-period and broad-band stations, was operated near Madaba, Jordan, complemented by one meteorological tower providing synchronized, continuous three-component measurements of wind speed. Results reveal a pronounced, predominantly linear increase of the logarithmic power of ground motion velocity with rising mean horizontal wind speed at all recording stations. Measurements in rough, mountainous terrain further identify a strong dependency of wind-induced noise on surface characteristics, such as topography and, therefore, demonstrate the necessity to consider wind direction as well. To assess the noise level of seismological recordings with respect to a dynamically changing wind field, we develop a methodology to account for the dependency of power spectral density of ground motion velocity on wind speed and wind direction for long, statistically significant periods. We further introduce the quantitative measure of the ground motion susceptibility to estimate the vulnerability of seismological recordings to the presence of wind.

7 CFR 1738.16 - Eligible entities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Eligible entities. 1738.16 Section 1738.16... Eligible entities. (a) RUS makes broadband loans to legally organized entities providing, or proposing to provide, broadband services in eligible rural communities. (1) Types of eligible entities include...

7 CFR 1738.16 - Eligible entities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 11 2011-01-01 2011-01-01 false Eligible entities. 1738.16 Section 1738.16... Eligible entities. (a) RUS makes broadband loans to legally organized entities providing, or proposing to provide, broadband services in eligible rural communities. (1) Types of eligible entities include...

77 FR 14340 - Proposed Information Collection; Comment Request; Broadband Technology Opportunities Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-09

... (PPRs) to capture quarterly and annual reports for each project type (Infrastructure, Public Computer... Information Collection; Comment Request; Broadband Technology Opportunities Program (BTOP) Quarterly and..., which included competitive grants to expand public computer center capacity and innovative programs to...

Broadband multiresonator quantum memory-interface.

PubMed

Moiseev, S A; Gerasimov, K I; Latypov, R R; Perminov, N S; Petrovnin, K V; Sherstyukov, O N

2018-03-05

In this paper we experimentally demonstrated a broadband scheme of the multiresonator quantum memory-interface. The microwave photonic scheme consists of the system of mini-resonators strongly interacting with a common broadband resonator coupled with the external waveguide. We have implemented the impedance matched quantum storage in this scheme via controllable tuning of the mini-resonator frequencies and coupling of the common resonator with the external waveguide. Proof-of-principal experiment has been demonstrated for broadband microwave pulses when the quantum efficiency of 16.3% was achieved at room temperature. By using the obtained experimental spectroscopic data, the dynamics of the signal retrieval has been simulated and promising results were found for high-Q mini-resonators in microwave and optical frequency ranges. The results pave the way for the experimental implementation of broadband quantum memory-interface with quite high efficiency η > 0.99 on the basis of modern technologies, including optical quantum memory at room temperature.

Cloud Properties of CERES-MODIS Edition 4 and CERES-VIIRS Edition 1

NASA Technical Reports Server (NTRS)

Sun-Mack, Sunny; Minnis, Patrick; Chang, Fu-Lung; Hong, Gang; Arduini, Robert; Chen, Yan; Trepte, Qing; Yost, Chris; Smith, Rita; Brown, Ricky;

Language Mapping in Multilingual Patients: Electrocorticography and Cortical Stimulation During Naming

PubMed Central

Cervenka, Mackenzie C.; Boatman-Reich, Dana F.; Ward, Julianna; Franaszczuk, Piotr J.; Crone, Nathan E.

2011-01-01

Multilingual patients pose a unique challenge when planning epilepsy surgery near language cortex because the cortical representations of each language may be distinct. These distinctions may not be evident with routine electrocortical stimulation mapping (ESM). Electrocorticography (ECoG) has recently been used to detect task-related spectral perturbations associated with functional brain activation. We hypothesized that using broadband high gamma augmentation (HGA, 60–150 Hz) as an index of cortical activation, ECoG would complement ESM in discriminating the cortical representations of first (L1) and second (L2) languages. We studied four adult patients for whom English was a second language, in whom subdural electrodes (a total of 358) were implanted to guide epilepsy surgery. Patients underwent ECoG recordings and ESM while performing the same visual object naming task in L1 and L2. In three of four patients, ECoG found sites activated during naming in one language but not the other. These language-specific sites were not identified using ESM. In addition, ECoG HGA was observed at more sites during L2 versus L1 naming in two patients, suggesting that L2 processing required additional cortical resources compared to L1 processing in these individuals. Post-operative language deficits were identified in three patients (one in L2 only). These deficits were predicted by ECoG spectral mapping but not by ESM. These results suggest that pre-surgical mapping should include evaluation of all utilized languages to avoid post-operative functional deficits. Finally, this study suggests that ECoG spectral mapping may potentially complement the results of ESM of language. PMID:21373361

Modified tandem gratings anastigmatic imaging spectrometer with oblique incidence for spectral broadband

NASA Astrophysics Data System (ADS)

Cui, Chengguang; Wang, Shurong; Huang, Yu; Xue, Qingsheng; Li, Bo; Yu, Lei

2015-09-01

A modified spectrometer with tandem gratings that exhibits high spectral resolution and imaging quality for solar observation, monitoring, and understanding of coastal ocean processes is presented in this study. Spectral broadband anastigmatic imaging condition, spectral resolution, and initial optical structure are obtained based on geometric aberration theory. Compared with conventional tandem gratings spectrometers, this modified design permits flexibility in selecting gratings. A detailed discussion of the optical design and optical performance of an ultraviolet spectrometer with tandem gratings is also included to explain the advantage of oblique incidence for spectral broadband.

Global Interoperability of Broadband Networks (GIBN): Project Overview

NASA Technical Reports Server (NTRS)

DePaula, Ramon P.

1998-01-01

Various issues associated with the Global Interoperability of Broadband Networks (GIBN) are presented in viewgraph form. Specific topics include GIBN principles, objectives and goals, and background. GIBN/NASA status, the Transpacific High Definition Video experiment, GIBN experiment selection criteria, satellite industry involvement, and current experiments associated with GIBN are also discussed.

Broadband nanoindentation of glassy polymers: Part II. Viscoplasticity

Treesearch

Joseph E. Jakes; Rod S. Lakes; Don S. Stone

2012-01-01

The relationship between hardness and flow stress in glassy polymers is examined. Materials studied include poly(methylmethacrylate), polystyrene, and polycarbonate. Properties are strongly rate dependent, so broadband nanoindentation creep (BNC) is used to measure hardness across a broad range of indentation strain rates (10-4 to 10 s

77 FR 39241 - Information Collection(s) Being Reviewed by the Federal Communications Commission, Comments...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-02

... Digital Literacy Training. Form Number: FCC Form 497; Low-Income Broadband Pilot Program Reporting Form... Board on Universal Service; Advancing Broadband Availability Through Digital Literacy Training, WC... ETCs to include plain, easy-to-understand language in all of their Lifeline marketing materials to...

47 CFR 27.1202 - Cable/BRS cross-ownership.

Code of Federal Regulations, 2010 CFR

2010-10-01

... MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27... modifications, assignments or transfers of control by cable operators of BRS stations shall include a showing... who holds or shares the power to vote such stock, to any person who has the sole power to sell such...

Enhancing the photon-extraction efficiency of site-controlled quantum dots by deterministically fabricated microlenses

NASA Astrophysics Data System (ADS)

Kaganskiy, Arsenty; Fischbach, Sarah; Strittmatter, André; Rodt, Sven; Heindel, Tobias; Reitzenstein, Stephan

2018-04-01

We report on the realization of scalable single-photon sources (SPSs) based on single site-controlled quantum dots (SCQDs) and deterministically fabricated microlenses. The fabrication process comprises the buried-stressor growth technique complemented with low-temperature in-situ electron-beam lithography for the integration of SCQDs into microlens structures with high yield and high alignment accuracy. The microlens-approach leads to a broadband enhancement of the photon-extraction efficiency of up to (21 ± 2)% and a high suppression of multi-photon events with g (2)(τ = 0) < 0.06 without background subtraction. The demonstrated combination of site-controlled growth of QDs and in-situ electron-beam lithography is relevant for arrays of efficient SPSs which, can be applied in photonic quantum circuits and advanced quantum computation schemes.

Optical coherence tomography in dermatology

NASA Astrophysics Data System (ADS)

Sattler, Elke; Kästle, Raphaela; Welzel, Julia

2013-06-01

Optical coherence tomography (OCT) is a noninvasive diagnostic method that offers a view into the superficial layers of the skin in vivo in real-time. An infrared broadband light source allows the investigation of skin architecture and changes up to a depth of 1 to 2 mm with a resolution between 15 and 3 μm, depending on the system used. Thus OCT enables evaluation of skin lesions, especially nonmelanoma skin cancers and inflammatory diseases, quantification of skin changes, visualization of parasitic infestations, and examination of other indications such as the investigation of nails. OCT provides a quick and useful diagnostic imaging technique for a number of clinical questions and is a valuable addition or complement to other noninvasive imaging tools such as dermoscopy, high-frequency ultrasound, and confocal laser scan microscopy.

Broadband Satellite Technologies and Markets Assessed

NASA Technical Reports Server (NTRS)

Wallett, Thomas M.

1999-01-01

The current usage of broadband (data rate greater than 64 kilobits per second (kbs)) for multimedia network computer applications is increasing, and the need for network communications technologies and systems to support this use is also growing. Satellite technology will likely be an important part of the National Information Infrastructure (NII) and the Global Information Infrastructure (GII) in the next decade. Several candidate communications technologies that may be used to carry a portion of the increased data traffic have been reviewed, and estimates of the future demand for satellite capacity have been made. A study was conducted by the NASA Lewis Research Center to assess the satellite addressable markets for broadband applications. This study effort included four specific milestones: (1) assess the changing nature of broadband applications and their usage, (2) assess broadband satellite and terrestrial technologies, (3) estimate the size of the global satellite addressable market from 2000 to 2010, and (4) identify how the impact of future technology developments could increase the utility of satellite-based transport to serve this market.

Bio-inspired heterogeneous composites for broadband vibration mitigation.

PubMed

Chen, Yanyu; Wang, Lifeng

2015-12-08

Structural biological materials have developed heterogeneous and hierarchical architectures that are responsible for the outstanding performance to provide protection against environmental threats including static and dynamic loading. Inspired by this observation, this research aims to develop new material and structural concepts for broadband vibration mitigation. The proposed composite materials possess a two-layered heterogeneous architecture where both layers consist of high-volume platelet-shape reinforcements and low-volume matrix, similar to the well-known "brick and mortar" microstructure of biological composites. Using finite element method, we numerically demonstrated that broadband wave attenuation zones can be achieved by tailoring the geometric features of the heterogeneous architecture. We reveal that the resulting broadband attenuation zones are gained by directly superimposing the attenuation zones in each constituent layer. This mechanism is further confirmed by the investigation into the phonon dispersion relation of each layer. Importantly, the broadband wave attenuation capability will be maintained when the mineral platelet orientation is locally manipulated, yet a contrast between the mineral platelet concentrations of the two constituent layers is essential. The findings of this work will provide new opportunities to design heterogeneous composites for broadband vibration mitigation and impact resistance under mechanically challenging environmental conditions.

Bio-inspired heterogeneous composites for broadband vibration mitigation

NASA Astrophysics Data System (ADS)

Chen, Yanyu; Wang, Lifeng

2015-12-01

Structural biological materials have developed heterogeneous and hierarchical architectures that are responsible for the outstanding performance to provide protection against environmental threats including static and dynamic loading. Inspired by this observation, this research aims to develop new material and structural concepts for broadband vibration mitigation. The proposed composite materials possess a two-layered heterogeneous architecture where both layers consist of high-volume platelet-shape reinforcements and low-volume matrix, similar to the well-known “brick and mortar” microstructure of biological composites. Using finite element method, we numerically demonstrated that broadband wave attenuation zones can be achieved by tailoring the geometric features of the heterogeneous architecture. We reveal that the resulting broadband attenuation zones are gained by directly superimposing the attenuation zones in each constituent layer. This mechanism is further confirmed by the investigation into the phonon dispersion relation of each layer. Importantly, the broadband wave attenuation capability will be maintained when the mineral platelet orientation is locally manipulated, yet a contrast between the mineral platelet concentrations of the two constituent layers is essential. The findings of this work will provide new opportunities to design heterogeneous composites for broadband vibration mitigation and impact resistance under mechanically challenging environmental conditions.

Broadband set-top box using MAP-CA processor

NASA Astrophysics Data System (ADS)

Bush, John E.; Lee, Woobin; Basoglu, Chris

2001-12-01

Advances in broadband access are expected to exert a profound impact in our everyday life. It will be the key to the digital convergence of communication, computer and consumer equipment. A common thread that facilitates this convergence comprises digital media and Internet. To address this market, Equator Technologies, Inc., is developing the Dolphin broadband set-top box reference platform using its MAP-CA Broadband Signal ProcessorT chip. The Dolphin reference platform is a universal media platform for display and presentation of digital contents on end-user entertainment systems. The objective of the Dolphin reference platform is to provide a complete set-top box system based on the MAP-CA processor. It includes all the necessary hardware and software components for the emerging broadcast and the broadband digital media market based on IP protocols. Such reference design requires a broadband Internet access and high-performance digital signal processing. By using the MAP-CA processor, the Dolphin reference platform is completely programmable, allowing various codecs to be implemented in software, such as MPEG-2, MPEG-4, H.263 and proprietary codecs. The software implementation also enables field upgrades to keep pace with evolving technology and industry demands.

VizieR Online Data Catalog: Circumstellar-interacting supernovae (Taddia+, 2015)

NASA Astrophysics Data System (ADS)

Taddia, F.; Sollerman, J.; Fremling, C.; Pastorello, A.; Leloudas, G.; Fransson, C.; Nyholm, A.; Stritzinger, M. D.; Ergon, M.; Roy, R.; Migotto, K.

2015-11-01

In Table 1 we report the list of 60 transients included in our sample. Thirty-five of them are SNe IIn, six are SNe Ibn, one is a SN Ia-CSM, 18 are SN IMs (if we also count SN 2009ip in the SN IMs, then we have 19 of these transients). With the NOT, long-slit spectra were obtained for the host galaxies of 13 SNe IIn, five SNe Ibn, one SN Ia-CSM, and 16 SN IMs (the derived metallicity for SN 2007sv was published in Tartaglia et al. 2015MNRAS.447..117T). The host galaxies observed at the NOT are marked with the letter "o" in the third column of Table 1. With the NOT, we also obtained broad-band R and narrow-band Hα images for the SNe IIn (except for SN 1995G) and Ibn. We complemented our observed sample with host galaxies whose metallicities (at the center of the galaxy or at the SN position) were already available in the literature (marked with the letter "l" in the third column of Table 1) or whose spectra were available in public archives (marked with the letter "a" in the third column of Table 1). (7 data files).

Cable Communications Revolution. Future: Broadband Communications, Local Origination.

ERIC Educational Resources Information Center

Peters, Robert W.

The revolution in two-way broadband communications envisioned for the future includes remote access to libraries, interactive educational programing, shopping at home, personal and property security, and many other services limited only by man's imagination and his ability to deliver the service at a price the consumer is willing and able to pay.…

47 CFR 90.1403 - Public safety broadband license conditions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... responsibilities of the Public Safety Broadband Licensee shall include the following: (1) Negotiation of the NSA... the 763-768 MHz and 793-798 MHz bands, within the technical and operational confines of the NSA. (4... equipment and applications. (5) Sole authority, which cannot be waived in the NSA, to approve, in...

47 CFR 90.1403 - Public safety broadband license conditions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... responsibilities of the Public Safety Broadband Licensee shall include the following: (1) Negotiation of the NSA... the 763-768 MHz and 793-798 MHz bands, within the technical and operational confines of the NSA. (4... equipment and applications. (5) Sole authority, which cannot be waived in the NSA, to approve, in...

47 CFR 90.1403 - Public safety broadband license conditions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... responsibilities of the Public Safety Broadband Licensee shall include the following: (1) Negotiation of the NSA... the 763-768 MHz and 793-798 MHz bands, within the technical and operational confines of the NSA. (4... equipment and applications. (5) Sole authority, which cannot be waived in the NSA, to approve, in...

Utilization of KSC Present Broadband Communications Data System for Digital Video Services

NASA Technical Reports Server (NTRS)

Andrawis, Alfred S.

2002-01-01

This report covers a visibility study of utilizing present KSC broadband communications data system (BCDS) for digital video services. Digital video services include compressed digital TV delivery and video-on-demand. Furthermore, the study examines the possibility of providing interactive video on demand to desktop personal computers via KSC computer network.

Broadband Access for Students at East Tennessee State University

ERIC Educational Resources Information Center

Sawyer, Thomas Scott

2013-01-01

The purpose of this study was to determine the availability of Internet access for students attending East Tennessee State University during the fall semester 2013. It has been unknown to what degree broadband access is available in the East Tennessee State University service area that includes counties in East Tennessee, Southwest Virginia, and…

Utilization of KSC Present Broadband Communications Data System For Digital Video Services

NASA Technical Reports Server (NTRS)

Andrawis, Alfred S.

2001-01-01

This report covers a visibility study of utilizing present KSC broadband communications data system (BCDS) for digital video services. Digital video services include compressed digital TV delivery and video-on-demand. Furthermore, the study examines the possibility of providing interactive video on demand to desktop personal computers via KSC computer network.

Complement Evasion Strategies of Viruses: An Overview

PubMed Central

Agrawal, Palak; Nawadkar, Renuka; Ojha, Hina; Kumar, Jitendra; Sahu, Arvind

2017-01-01

Being a major first line of immune defense, the complement system keeps a constant vigil against viruses. Its ability to recognize large panoply of viruses and virus-infected cells, and trigger the effector pathways, results in neutralization of viruses and killing of the infected cells. This selection pressure exerted by complement on viruses has made them evolve a multitude of countermeasures. These include targeting the recognition molecules for the avoidance of detection, targeting key enzymes and complexes of the complement pathways like C3 convertases and C5b-9 formation – either by encoding complement regulators or by recruiting membrane-bound and soluble host complement regulators, cleaving complement proteins by encoding protease, and inhibiting the synthesis of complement proteins. Additionally, viruses also exploit the complement system for their own benefit. For example, they use complement receptors as well as membrane regulators for cellular entry as well as their spread. Here, we provide an overview on the complement subversion mechanisms adopted by the members of various viral families including Poxviridae, Herpesviridae, Adenoviridae, Flaviviridae, Retroviridae, Picornaviridae, Astroviridae, Togaviridae, Orthomyxoviridae and Paramyxoviridae. PMID:28670306

Array Of Sensors Measures Broadband Radiation

NASA Technical Reports Server (NTRS)

Hoffman, James W.; Grush, Ronald G.

1994-01-01

Multiple broadband radiation sensors aimed at various portions of total field of view. All sensors mounted in supporting frame, serving as common heat sink and temperature reference. Each sensor includes heater winding and differential-temperature-sensing bridge circuit. Power in heater winding adjusted repeatedly in effort to balance bridge circuit. Intended to be used aboard satellite in orbit around Earth to measure total radiation emitted, at various viewing angles, by mosaic of "footprint" areas (each defined by its viewing angle) on surface of Earth. Modified versions of array useful for angle-resolved measurements of broadband radiation in laboratory and field settings on Earth.

Flexible, transparent and ultra-broadband photodetector based on large-area WSe2 film for wearable devices

NASA Astrophysics Data System (ADS)

Zheng, Zhaoqiang; Zhang, Tanmei; Yao, Jiandomg; Zhang, Yi; Xu, Jiarui; Yang, Guowei

2016-06-01

Although two-dimensional (2D) materials have attracted considerable research interest for use in the development of innovative wearable optoelectronic systems, the integrated optoelectronic performance of 2D materials photodetectors, including flexibility, transparency, broadband response and stability in air, remains quite low to date. Here, we demonstrate a flexible, transparent, high-stability and ultra-broadband photodetector made using large-area and highly-crystalline WSe2 films that were prepared by pulsed-laser deposition (PLD). Benefiting from the 2D physics of WSe2 films, this device exhibits excellent average transparency of 72% in the visible range and superior photoresponse characteristics, including an ultra-broadband detection spectral range from 370 to 1064 nm, reversible photoresponsivity approaching 0.92 A W-1, external quantum efficiency of up to 180% and a relatively fast response time of 0.9 s. The fabricated photodetector also demonstrates outstanding mechanical flexibility and durability in air. Also, because of the wide compatibility of the PLD-grown WSe2 film, we can fabricate various photodetectors on multiple flexible or rigid substrates, and all these devices will exhibit distinctive switching behavior and superior responsivity. These indicate a possible new strategy for the design and integration of flexible, transparent and broadband photodetectors based on large-area WSe2 films, with great potential for practical applications in the wearable optoelectronic devices.

Determination of Magnitude and Location of Earthquakes With Only Five Seconds of a Three Component Broadband Sensor Signal Located Near Bogota, Colombia Using Support Vector Machines

NASA Astrophysics Data System (ADS)

Ochoa Gutierrez, L. H.; Vargas Jiménez, C. A.; Niño Vasquez, L. F., Sr.

2017-12-01

Early warning generation for earthquakes that occur near the city of Bogotá-Colombia is extremely important. Using the information of a broadband and three component station, property of the Servicio Geológico Colombiano (SGC), called El Rosal, which is located very near the city, we developed a model based on support vector machines techniques (SVM), with a standardized polynomial kernel, using as descriptors or input data, seismic signal features, complemented by the hipocentral parameters calculated for each one of the reported events. The model was trained and evaluated by cross correlation and was used to predict, with only five seconds of signal, the magnitude and location of a seismic event. With the proposed model we calculated local magnitude with an accuracy of 0.19 units of magnitude, epicentral distance with an accuracy of about 11 k, depth with a precision of approximately 40 km and the azimuth of arrival with a precision of 45°. This research made a significant contribution for early warning generation for the country, in particular for the city of Bogotá. These models will be implemented in the future in the "Red Sismológica de la Sabana de Bogotá y sus Alrededores (RSSB)" which belongs to the Universidad Nacional de Colombia.

Networking seismological data exchange in Europe

NASA Astrophysics Data System (ADS)

Sleeman, Reinoud; van Eck, Torild; van den Hazel, Gert-Jan; Trani, Luca; Spinuso, Alessandro

2010-05-01

The mission of the ORFEUS Data Centre (ODC) is to collect and archive high-quality seismic broadband waveform data from European-Mediterranean organizations and to provide open access to this data for monitoring and research purposes by the scientific community. The core activity of the ODC is to run an automatic, sustainable system to achieve this mission. Our 4 key operations are: data exchange protocols, quality control procedures, data management and data services. All these activities at the ODC benefit from developments within the EC Infrastructure (I3) project NERIES (Network of Research Infrastructure for European Seismology). For the data acquisition the ODC uses different standard, real-time data exchange protocols (e.g. Antelope, SeedLink, Scream) to ensure a very high data availability from stations in the Virtual European Broadband Seismic Network (VEBSN), which currently exists of about 500 BB stations. Within the data services a number of tools (e.g. Wilber II, NetDC, BreqFast, AutoDRM and webforms) are in place to serve the scientific community. These are currently being complemented by webservices and an integrated portal. The data management part relies on a simple flat file structure and a MySQL data management system on which both ArcLink and the Generic Data Interface (GDI) operate. In this presentation we will present an overview of the different aspects concerning data acquisition, services and management at ODC.

Site selection for the future stations of the french permanent broadband network

NASA Astrophysics Data System (ADS)

Vergne, Jérôme; Charade, Olivier

2013-04-01

RESIF (REseau SIsmologique et géodésique Français) is a new French research infrastructure dedicated to the observation of earth deformation based on seismic and geodetic instruments mainly located in France. One of its major component, called RESIF-CLB (Construction Large Bande), is devoted to the evolution of the permanent seismic broadband network in metropolitan France with the objective to complement the 45 existing stations with ~155 new stations within the next eight years. This network will be used for various scientific objectives including deep structures imaging and national seismicity monitoring. The chosen network topology consists in a backbone of homogeneously distributed stations (long wavelength array) completed by additional stations in seismically active regions. Management of the RESIF-CLB project is carried out by the technical division of INSU (Institut National des Sciences de l'Univers) who will rely on eight regional observatories and the CEA-LDG for the construction and operation of the stations. To optimize the performance of the network, we put a strong emphasis on the standardization of the stations in term of vault types, scientific and technical instrumentation and operation procedures. We also set up a procedure for site selection requiring that every potential site has to be tested for at least 3 weeks with a minimalist installation. Analysis of the continuous ambient noise records is then included in a standardized report submitted to all committed partners for acceptance. During the last two years, about 60 potential new sites have been tested, spanning various places and environments. We present a review of the seismic noise measurements at these sites and discuss the influence of different types of noise sources depending on the frequency band of interest. For example, we show that regional population distribution can be used as a proxy to infer the noise level at frequencies higher than 1 Hz. Based on similar noise analyses at existing permanent sites, we also discuss the fair benefit of our site testing procedure for the estimation of the long period noise level once the station is settled.

System and method for detection of dispersed broadband signals

DOEpatents

Qian, S.; Dunham, M.E.

1999-06-08

A system and method for detecting the presence of dispersed broadband signals in real time are disclosed. The present invention utilizes a bank of matched filters for detecting the received dispersed broadband signals. Each matched filter uses a respective robust time template that has been designed to approximate the dispersed broadband signals of interest, and each time template varies across a spectrum of possible dispersed broadband signal time templates. The received dispersed broadband signal x(t) is received by each of the matched filters, and if one or more matches occurs, then the received data is determined to have signal data of interest. This signal data can then be analyzed and/or transmitted to Earth for analysis, as desired. The system and method of the present invention will prove extremely useful in many fields, including satellite communications, plasma physics, and interstellar research. The varying time templates used in the bank of matched filters are determined as follows. The robust time domain template is assumed to take the form w(t)=A(t)cos[l brace]2[phi](t)[r brace]. Since the instantaneous frequency f(t) is known to be equal to the derivative of the phase [phi](t), the trajectory of a joint time-frequency representation of x(t) is used as an approximation of [phi][prime](t). 10 figs.

System and method for detection of dispersed broadband signals

DOEpatents

Qian, Shie; Dunham, Mark E.

1999-06-08

A system and method for detecting the presence of dispersed broadband signals in real time. The present invention utilizes a bank of matched filters for detecting the received dispersed broadband signals. Each matched filter uses a respective robust time template that has been designed to approximate the dispersed broadband signals of interest, and each time template varies across a spectrum of possible dispersed broadband signal time templates. The received dispersed broadband signal x(t) is received by each of the matched filters, and if one or more matches occurs, then the received data is determined to have signal data of interest. This signal data can then be analyzed and/or transmitted to Earth for analysis, as desired. The system and method of the present invention will prove extremely useful in many fields, including satellite communications, plasma physics, and interstellar research. The varying time templates used in the bank of matched filters are determined as follows. The robust time domain template is assumed to take the form w(t)=A(t)cos{2.phi.(t)}. Since the instantaneous frequency f(t) is known to be equal to the derivative of the phase .phi.(t), the trajectory of a joint time-frequency representation of x(t) is used as an approximation of .phi.'(t).

Multi-wavelength Observations of the Enduring Type IIn Supernovae 2005ip and 2006jd1

NASA Technical Reports Server (NTRS)

Stritzinger, Maximilian; Taddia, Francesco; Fransson, Claes; Fox, Ori D.; Morrell, Nidia; Phillips, M. M.; Sollerman, Jesper; Anderson, J. P.; Bolft, Luis; Brown, Peter J.;

Broadband thermal optical limiter for the protection of eyes and sensors

NASA Astrophysics Data System (ADS)

Justus, Brian L.; Huston, Alan L.; Campillo, Anthony J.

1994-05-01

A broadband thermal optical limiter for protecting a light sensitive object from intense laser beams at all near ultraviolet, visible and near infrared wavelengths is disclosed. The broadband thermal optical limiter comprises: a sample cell containing a solution of broadband absorber material dissolved in a thermal solvent; and a first optical device for converging an incident laser beam into the sample cell. The sample cell is responsive to a converged incident laser beam below a predetermined intensity level for passing therethrough the converged incident laser beam below the predetermined intensity level. The sample cell is also responsive to a converged incident laser beam at or above a predetermined intensity level for thermally defocusing substantially all of the converged incident laser beam in different directions and passing therethrough only a remaining small portion of the converged incident laser beam at or above the predetermined intensity level. The broadband thermal optical limiter further includes a second optical device for focusing substantially all of the laser beam passing through the sample cell into the light sensitive object to be protected.

Device and method for generating a beam of acoustic energy from a borehole, and applications thereof

DOEpatents

Vu, Cung Khac; Sinha, Dipen N; Pantea, Cristian; Nihei, Kurt T; Schmitt, Denis P; Skelt, Christopher

2013-10-01

In some aspects of the invention, a method of generating a beam of acoustic energy in a borehole is disclosed. The method includes generating a first broad-band acoustic pulse at a first broad-band frequency range having a first central frequency and a first bandwidth spread; generating a second broad-band acoustic pulse at a second broad-band frequency range different than the first frequency range having a second central frequency and a second bandwidth spread, wherein the first acoustic pulse and second acoustic pulse are generated by at least one transducer arranged on a tool located within the borehole; and transmitting the first and the second broad-band acoustic pulses into an acoustically non-linear medium, wherein the composition of the non-linear medium produces a collimated pulse by a non-linear mixing of the first and second acoustic pulses, wherein the collimated pulse has a frequency equal to the difference in frequencies between the first central frequency and the second central frequency and a bandwidth spread equal to the sum of the first bandwidth spread and the second bandwidth spread.

High-power Broadband Organic THz Generator

PubMed Central

Jeong, Jae-Hyeok; Kang, Bong-Joo; Kim, Ji-Soo; Jazbinsek, Mojca; Lee, Seung-Heon; Lee, Seung-Chul; Baek, In-Hyung; Yun, Hoseop; Kim, Jongtaek; Lee, Yoon Sup; Lee, Jae-Hyeok; Kim, Jae-Ho; Rotermund, Fabian; Kwon, O-Pil

2013-01-01

The high-power broadband terahertz (THz) generator is an essential tool for a wide range of THz applications. Here, we present a novel highly efficient electro-optic quinolinium single crystal for THz wave generation. For obtaining intense and broadband THz waves by optical-to-THz frequency conversion, a quinolinium crystal was developed to fulfill all the requirements, which are in general extremely difficult to maintain simultaneously in a single medium, such as a large macroscopic electro-optic response and excellent crystal characteristics including a large crystal size with desired facets, good environmental stability, high optical quality, wide transparency range, and controllable crystal thickness. Compared to the benchmark inorganic and organic crystals, the new quinolinium crystal possesses excellent crystal properties and THz generation characteristics with broader THz spectral coverage and higher THz conversion efficiency at the technologically important pump wavelength of 800 nm. Therefore, the quinolinium crystal offers great potential for efficient and gap-free broadband THz wave generation. PMID:24220234

All-dielectric resonant cavity-enabled metals with broadband optical transparency

NASA Astrophysics Data System (ADS)

Liu, Zhengqi; Zhang, Houjiao; Liu, Xiaoshan; Pan, Pingping; Liu, Yi; Tang, Li; Liu, Guiqiang

2017-06-01

Metal films with broadband optical transparency are desirable in many optoelectronic devices, such as displays, smart windows, light-emitting diodes and infrared detectors. As bare metal is opaque to light, this issue of transparency attracts great scientific interest. In this work, we proposed and demonstrated a feasible and universal approach for achieving broadband optical transparent (BOT) metals by utilizing all-dielectric resonant cavities. Resonant dielectrics provide optical cavity modes and couple strongly with the surface plasmons of the metal film, and therefore produce a broadband near-unity optical transparent window. The relative enhancement factor (EF) of light transmission exceeds 3400% in comparison with that of pure metal film. Moreover, the transparent metal motif can be realized by other common metals including gold (Au), silver (Ag) and copper (Cu). These optical features together with the fully retained electric and mechanical properties of a natural metal suggest that it will have wide applications in optoelectronic devices.

High-power broadband organic THz generator.

PubMed

Jeong, Jae-Hyeok; Kang, Bong-Joo; Kim, Ji-Soo; Jazbinsek, Mojca; Lee, Seung-Heon; Lee, Seung-Chul; Baek, In-Hyung; Yun, Hoseop; Kim, Jongtaek; Lee, Yoon Sup; Lee, Jae-Hyeok; Kim, Jae-Ho; Rotermund, Fabian; Kwon, O-Pil

2013-11-13

The high-power broadband terahertz (THz) generator is an essential tool for a wide range of THz applications. Here, we present a novel highly efficient electro-optic quinolinium single crystal for THz wave generation. For obtaining intense and broadband THz waves by optical-to-THz frequency conversion, a quinolinium crystal was developed to fulfill all the requirements, which are in general extremely difficult to maintain simultaneously in a single medium, such as a large macroscopic electro-optic response and excellent crystal characteristics including a large crystal size with desired facets, good environmental stability, high optical quality, wide transparency range, and controllable crystal thickness. Compared to the benchmark inorganic and organic crystals, the new quinolinium crystal possesses excellent crystal properties and THz generation characteristics with broader THz spectral coverage and higher THz conversion efficiency at the technologically important pump wavelength of 800 nm. Therefore, the quinolinium crystal offers great potential for efficient and gap-free broadband THz wave generation.

A Selected Bibliography. A Survey of Technical Requirements for Broadband Cable Teleservices; Volume Seven.

ERIC Educational Resources Information Center

Holmberg, N.; And Others

A selected bibliography is presented in this last volume of the series. The citations included data from as long ago as 30 years, although the majority are of recent vintage. These publications are concerned with cable television (CATV) and broadband cable systems which offer or propose to offer various teleservices in addition to one-way…

The SCEC Broadband Platform: A Collaborative Open-Source Software Package for Strong Ground Motion Simulation and Validation

NASA Astrophysics Data System (ADS)

Silva, F.; Maechling, P. J.; Goulet, C. A.; Somerville, P.; Jordan, T. H.

2014-12-01

The Southern California Earthquake Center (SCEC) Broadband Platform is a collaborative software development project involving geoscientists, earthquake engineers, graduate students, and the SCEC Community Modeling Environment. The SCEC Broadband Platform (BBP) is open-source scientific software that can generate broadband (0-100Hz) ground motions for earthquakes, integrating complex scientific modules that implement rupture generation, low and high-frequency seismogram synthesis, non-linear site effects calculation, and visualization into a software system that supports easy on-demand computation of seismograms. The Broadband Platform operates in two primary modes: validation simulations and scenario simulations. In validation mode, the Platform runs earthquake rupture and wave propagation modeling software to calculate seismograms for a well-observed historical earthquake. Then, the BBP calculates a number of goodness of fit measurements that quantify how well the model-based broadband seismograms match the observed seismograms for a certain event. Based on these results, the Platform can be used to tune and validate different numerical modeling techniques. In scenario mode, the Broadband Platform can run simulations for hypothetical (scenario) earthquakes. In this mode, users input an earthquake description, a list of station names and locations, and a 1D velocity model for their region of interest, and the Broadband Platform software then calculates ground motions for the specified stations. Working in close collaboration with scientists and research engineers, the SCEC software development group continues to add new capabilities to the Broadband Platform and to release new versions as open-source scientific software distributions that can be compiled and run on many Linux computer systems. Our latest release includes 5 simulation methods, 7 simulation regions covering California, Japan, and Eastern North America, the ability to compare simulation results against GMPEs, and several new data products, such as map and distance-based goodness of fit plots. As the number and complexity of scenarios simulated using the Broadband Platform increases, we have added batching utilities to substantially improve support for running large-scale simulations on computing clusters.

Flux and polarization signals of spatially inhomogeneous gaseous exoplanets

NASA Astrophysics Data System (ADS)

Karalidi, T.; Stam, D. M.; Guirado, D.

2013-07-01

Aims: We present numerically calculated, disk-integrated, spectropolarimetric signals of starlight that is reflected by vertically and horizontally inhomogeneous gaseous exoplanets. We include various spatial features that are present on Solar System's gaseous planets: belts and zones, cyclonic spots, and polar hazes, to test whether such features leave traces in the disk-integrated fux and polarization signals. Methods: Broadband flux and polarization signals of starlight that is reflected by gaseous exoplanets are calculated using an efficient, adding-doubling radiative transfer code, that fully includes single and multiple scattering and polarization. The planetary model atmospheres are vertically inhomogeneous and can be horizontally inhomogeneous, and contain gas molecules and/or cloud and/or aerosol particles. Results: The broadband flux and polarization signals are sensitive to cloud top pressures, although in the presence of local pressure differences, such as in belts and clouds, the flux and polarization phase functions have similar shapes as those of horizontally homogeneous planets. Fitting flux phase functions of a planet with belts and zones using a horizontally homogeneous planet could theoretically yield cloud top pressures that differ by a few hundred mbar from those derived from fitting polarization phase functions. In practice, however, observational errors and uncertainties in cloud properties would make such a fit unreliable. A cyclonic spot like Jupiter's Great Red Spot, covering a few percent of the disk, located in equatorial regions, and rotating in and out of the observer's view yields a temporal variation of a few percent in the broadband flux and a few percent in the degree of polarization. Polar hazes leave strong traces in the polarization of reflected starlight in spatially resolved observations, especially seen at phase angles near 90°. Integrated across the planetary disk, polar hazes that cover only part of the planetary disk, change the broadband degree of polarization of the reflected light by a few percent. Such hazes have only small effects on locally reflected broadband fluxes and negligible effects on disk-integrated broadband fluxes. Conclusions: Deriving the presence of belts and zones in the atmospheres of gaseous exoplanets from broadband flux and polarization observations will be extremely difficult. Cyclonic spots could leave temporal changes in the broadband flux and polarization signals of a few percent. Polar hazes that cover a fraction of the planetary disk, and that are composed of small, Rayleigh scattering particles, change the broadband degree of polarization by at most a few percent.

Wide-angle, polarization-insensitive and broadband absorber based on eight-fold symmetric SRRs metamaterial

NASA Astrophysics Data System (ADS)

Wu, Dong; Liu, Yumin; Yu, Zhongyuan; Chen, Lei; Ma, Rui; Li, Yutong; Li, Ruifang; Ye, Han

2016-12-01

In this paper, we propose a novel three dimensional metamaterial design with eight-fold rotational symmetry that shows a polarization-insensitive, wide-angle and broadband perfect absorption in the microwave band. By simulation, the polarization-insensitive absorption is over 90% between 26.9 GHz to 32.9 GHz, and the broadband absorption remains a good absorption performance to a wide incident angles for both TE and TM polarizations. The magnetic field distribution are investigated to interpret the physical mechanism of broadband absorption. The broadband absorption is based on overlapping the multiple magnetic resonances at the neighboring frequencies by coupling effects of multiple metallic split-ring resonators (SRRs). Moreover, it is demonstrate that the designed structure can be extended to other frequencies by scale down the size of the unit cell, such as the visible frequencies. The simulated results show that the absorption of the smaller absorber is above 90% in the frequency range from 467 THz to 765 THz(392-642 nm), which include orange to purple light in visible region(400-760nm). The wide-angle and polarization-insensitive stabilities of the smaller absorber is also demonstrated at visible region. The proposed work provides a new design of realization of a polarization-insensitive, wide-angle and broadband absorber ranging different frequency bands, and such a structure has potential application in the fields of solar cell, imaging and detection.

Detailed Balance Limit of Efficiency of Broadband-Pumped Lasers.

PubMed

Nechayev, Sergey; Rotschild, Carmel

2017-09-13

Broadband light sources are a wide class of pumping schemes for lasers including LEDs, sunlight and flash lamps. Recently, efficient coupling of broadband light to high-quality micro-cavities has been demonstrated for on-chip applications and low-threshold solar-pumped lasers via cascade energy transfer. However, the conversion of incoherent to coherent light comes with an inherent price of reduced efficiency, which has yet to be assessed. In this paper, we derive the detailed balance limit of efficiency of broadband-pumped lasers and discuss how it is affected by the need to maintain a threshold population inversion and thermodynamically dictated minimal Stokes' shift. We show that lasers' slope efficiency is analogous to the nominal efficiency of solar cells, limited by thermalisation losses and additional unavoidable Stokes' shift. The lasers' power efficiency is analogous to the detailed balance limit of efficiency of solar cells, affected by the cavity mirrors and impedance matching factor, respectively. As an example we analyze the specific case of solar-pumped sensitized Nd 3+ :YAG-like lasers and define the conditions to reach their thermodynamic limit of efficiency. Our work establishes an upper theoretical limit for the efficiency of broadband-pumped lasers. Our general, yet flexible model also provides a way to incorporate other optical and thermodynamic losses and, hence, to estimate the efficiency of non-ideal broadband-pumped lasers.

Broadband Microwave Wireless Power Transfer for Weak-Signal and Multipath Environments

NASA Technical Reports Server (NTRS)

Barton, Richard J.

2014-01-01

In this paper, we study the potential benefits of using relatively broadband wireless power transmission WPT strategies in both weak-signal and multipath environments where traditional narrowband strategies can be very inefficient. The paper is primarily a theoretical and analytical treatment of the problem that attempts to derive results that are widely applicable to many different WPT applications, including space solar power SSP.

Femtosecond Broad-Band Sum Frequency Generation Spectroscopy: Measurements of Ethanol Fuel Cell Catalysis

DTIC Science & Technology

2012-12-03

The public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing...Washington Headquarters Services, Directorate for Information Operations and Reports , 1215 Jefferson Davis Highway, Suite 1204, Arlington VA, 22202-4302... REPORT Femtosecond Broad-Band Sum Frequency Generation Spectroscopy: Measurements of Ethanol Fuel Cell Catalysis 14. ABSTRACT 16. SECURITY

Forward flight effects on broadband shock associated noise of supersonic jets

NASA Technical Reports Server (NTRS)

Tam, Christopher K. W.

1989-01-01

The stochastic model theory of TAM (1987, 1989) for broadband shock associated noise was extended to include the effects of forward flight. The theory was applied to the forward flight simulation experiments of Norum and Shearin (1984, 1986, and 1988). Good agreement is found between calculated and measured far-field noise spectra over the flight Mach number range of 0.0 to 0.4.

The SCEC Broadband Platform: A Collaborative Open-Source Software Package for Strong Ground Motion Simulation and Validation

NASA Astrophysics Data System (ADS)

Silva, F.; Maechling, P. J.; Goulet, C.; Somerville, P.; Jordan, T. H.

2013-12-01

The Southern California Earthquake Center (SCEC) Broadband Platform is a collaborative software development project involving SCEC researchers, graduate students, and the SCEC Community Modeling Environment. The SCEC Broadband Platform is open-source scientific software that can generate broadband (0-100Hz) ground motions for earthquakes, integrating complex scientific modules that implement rupture generation, low and high-frequency seismogram synthesis, non-linear site effects calculation, and visualization into a software system that supports easy on-demand computation of seismograms. The Broadband Platform operates in two primary modes: validation simulations and scenario simulations. In validation mode, the Broadband Platform runs earthquake rupture and wave propagation modeling software to calculate seismograms of a historical earthquake for which observed strong ground motion data is available. Also in validation mode, the Broadband Platform calculates a number of goodness of fit measurements that quantify how well the model-based broadband seismograms match the observed seismograms for a certain event. Based on these results, the Platform can be used to tune and validate different numerical modeling techniques. During the past year, we have modified the software to enable the addition of a large number of historical events, and we are now adding validation simulation inputs and observational data for 23 historical events covering the Eastern and Western United States, Japan, Taiwan, Turkey, and Italy. In scenario mode, the Broadband Platform can run simulations for hypothetical (scenario) earthquakes. In this mode, users input an earthquake description, a list of station names and locations, and a 1D velocity model for their region of interest, and the Broadband Platform software then calculates ground motions for the specified stations. By establishing an interface between scientific modules with a common set of input and output files, the Broadband Platform facilitates the addition of new scientific methods, which are written by earth scientists in a number of languages such as C, C++, Fortran, and Python. The Broadband Platform's modular design also supports the reuse of existing software modules as building blocks to create new scientific methods. Additionally, the Platform implements a wrapper around each scientific module, converting input and output files to and from the specific formats required (or produced) by individual scientific codes. Working in close collaboration with scientists and research engineers, the SCEC software development group continues to add new capabilities to the Broadband Platform and to release new versions as open-source scientific software distributions that can be compiled and run on many Linux computer systems. Our latest release includes the addition of 3 new simulation methods and several new data products, such as map and distance-based goodness of fit plots. Finally, as the number and complexity of scenarios simulated using the Broadband Platform increase, we have added batching utilities to substantially improve support for running large-scale simulations on computing clusters.

Method and means of transmitting and receiving broad-band unipolar, ultrasonic pulses for ultrasonic inspection

DOEpatents

Thompson, D.O.; Hsu, D.K.

1993-12-14

The invention includes a means and method for transmitting and receiving broadband, unipolar, ultrasonic pulses for ultrasonic inspection. The method comprises generating a generally unipolar ultrasonic stress pulse from a low impedance voltage pulse transmitter along a low impedance electrical pathway to an ultrasonic transducer, and receiving the reflected echo of the pulse by the transducer, converting it to a voltage signal, and passing it through a high impedance electrical pathway to an output. The means utilizes electrical components according to the method. The means and method allow a single transducer to be used in a pulse/echo mode, and facilitates alternatingly transmitting and receiving the broadband, unipolar, ultrasonic pulses. 25 figures.

Method and means of transmitting and receiving broad-band unipolar, ultrasonic pulses for ultrasonic inspection

DOEpatents

Thompson, Donald O.; Hsu, David K.

1993-12-14

The invention includes a means and method for transmitting and receiving broadband, unipolar, ultrasonic pulses for ultrasonic inspection. The method comprises generating a generally unipolar ultrasonic stress pulse from a low impedance voltage pulse transmitter along a low impedance electrical pathway to an ultrasonic transducer, and receiving the reflected echo of the pulse by the transducer, converting it to a voltage signal, and passing it through a high impedance electrical pathway to an output. The means utilizes electrical components according to the method. The means and method allow a single transducer to be used in a pulse/echo mode, and facilitates alternatingly transmitting and receiving the broadband, unipolar, ultrasonic pulses.

THE PATHOPHYSIOLOGY OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION AND THE COMPLEMENT PATHWAY AS A THERAPEUTIC TARGET

PubMed Central

Schmidt-Erfurth, Ursula; van Lookeren Campagne, Menno; Henry, Erin C.; Brittain, Christopher

2017-01-01

Purpose: Geographic atrophy (GA) is an advanced, vision-threatening form of age-related macular degeneration (AMD) affecting approximately five million individuals worldwide. To date, there are no approved therapeutics for GA treatment; however, several are in clinical trials. This review focuses on the pathophysiology of GA, particularly the role of complement cascade dysregulation and emerging therapies targeting the complement cascade. Methods: Primary literature search on PubMed for GA, complement cascade in age-related macular degeneration. ClinicalTrials.gov was searched for natural history studies in GA and clinical trials of drugs targeting the complement cascade for GA. Results: Cumulative damage to the retina by aging, environmental stress, and other factors triggers inflammation via multiple pathways, including the complement cascade. When regulatory components in these pathways are compromised, as with several GA-linked genetic risk factors in the complement cascade, chronic inflammation can ultimately lead to the retinal cell death characteristic of GA. Complement inhibition has been identified as a key candidate for therapeutic intervention, and drugs targeting the complement pathway are currently in clinical trials. Conclusion: The complement cascade is a strategic target for GA therapy. Further research, including on natural history and genetics, is crucial to expand the understanding of GA pathophysiology and identify effective therapeutic targets. PMID:27902638

The Stratospheric Observatory for Infrared Astronomy (sofia)

NASA Astrophysics Data System (ADS)

Gehrz, R. D.; Becklin, E. E.

2010-06-01

The Stratospheric Observatory for Infrared Astronomy (SOFIA) is a joint U.S./German Project to develop and operate a 2.5-meter infrared airborne telescope in a Boeing 747-SP that flies in the stratosphere at altitudes as high as 45,000 feet and is capable of observations from 0.3 microns to 1.6 mm with an average transmission of greater than 80 percent. SOFIA will be staged out of the NASA Dryden Flight Research Center aircraft operations facility at Palmdale, CA and the SOFIA Science Mission Operations Center (SSMOC) will be located at NASA Ames Research Center, Moffett Field, CA. Open door test flights began in December of 2009. First science flights will begin in 2010, and the number of flights will ramp up annually with a flight rate of over 100 eight to ten hour flights per year expected by 2014. The observatory is expected to operate until the mid 2030's. We review the status of the SOFIA facility and its initial complement of eight focal plane instruments that include broadband imagers, moderate resolution spectrographs that will resolve broad features due to dust and large molecules, and high resolution spectrometers capable of studying the kinematics of molecular and atomic gas lines at km/s resolution.

Strong Broadband Terahertz Optical Activity through Control of the Blaschke Phase with Chiral Metasurfaces

NASA Astrophysics Data System (ADS)

Cole, Michael A.; Chen, Wen-chen; Liu, Mingkai; Kruk, Sergey S.; Padilla, Willie J.; Shadrivov, Ilya V.; Powell, David A.

2017-07-01

We demonstrate terahertz chiral metamaterials that achieve resonant transmission and strong optical activity. This response is realized in a metasurface coupled to its Babinet complement, with additional twist. Uniquely, the optical activity achieved in this type of metamaterial is weakly dispersive around the resonant transmission maxima, but it can be highly dispersive around the transmission minima. It has recently been shown that this unique optical activity response is closely related to zeros in the transmission spectra of circular polarizations through the Kramers-Kronig relations and strong resonant features in the optical activity spectrum corresponding to the Blaschke phase terms. Here we demonstrate how modifying the meta-atom geometry greatly affects the location and magnitude of these Blaschke phase terms. We study three different meta-atoms, which are variations on the simple cross structure. Their responses are measured using terahertz time-domain spectroscopy and analyzed via numerical simulations.

Impact of Azimuthally Controlled Fluidic Chevrons on Jet Noise

NASA Technical Reports Server (NTRS)

Henderson, Brenda S.; Norum, Thomas D.

2008-01-01

The impact of azimuthally controlled air injection on broadband shock noise and mixing noise for single and dual stream jets was investigated. The single stream experiments focused on noise reduction for low supersonic jet exhausts. Dual stream experiments included high subsonic core and fan conditions and supersonic fan conditions with transonic core conditions. For the dual stream experiments, air was injected into the core stream. Significant reductions in broadband shock noise were achieved in a single jet with an injection mass flow equal to 1.2% of the core mass flow. Injection near the pylon produced greater broadband shock noise reductions than injection at other locations around the nozzle periphery. Air injection into the core stream did not result in broadband shock noise reduction in dual stream jets. Fluidic injection resulted in some mixing noise reductions for both the single and dual stream jets. For subsonic fan and core conditions, the lowest noise levels were obtained when injecting on the side of the nozzle closest to the microphone axis.

Noise in any frequency range can enhance information transmission in a sensory neuron

NASA Astrophysics Data System (ADS)

Levin, Jacob E.

1997-05-01

The effect of noise on the neural encoding of broadband signals was investigated in the cricket cercal system, a mechanosensory system sensitive to small near-field air particle disturbances. Known air current stimuli were presented to the cricket through audio speakers in a controlled environment in a variety of background noise conditions. Spike trains from the second layer of neuronal processing, the primary sensory interneurons, were recorded with intracellular Electrodes and the performance of these neurons characterized with the tools of information theory. SNR, mutual information rates, and other measures of encoding accuracy were calculated for single frequency, narrowband, and broadband signals over the entire amplitude sensitivity range of the cells, in the presence of uncorrelated noise background also spanning the cells' frequency and amplitude sensitivity range. Significant enhancements of transmitted information through the addition of external noise were observed regardless of the frequency range of either the signal or noise waveforms, provided both were within the operating range of the cell. Considerable improvements in signal encoding were observed for almost an entire order of magnitude of near-threshold signal amplitudes. This included sinusoidal signals embedded in broadband white noise, broadband signals in broadband noise, and even broadband signals presented with narrowband noise in a completely non-overlapping frequency range. The noise related increases in mutual information rate for broadband signals were as high as 150%, and up to 600% increases in SNR were observed for sinusoidal signals. Additionally, it was shown that the amount of information about the signal carried, on average, by each spike was INCREASED for small signals when presented with noise—implying that added input noise can, in certain situations, actually improve the accuracy of the encoding process itself.

All electrical propagating spin wave spectroscopy with broadband wavevector capability

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ciubotaru, F., E-mail: Florin.Ciubotaru@imec.be; KU Leuven, Departement Electrotechniek; Devolder, T.

2016-07-04

We developed an all electrical experiment to perform the broadband phase-resolved spectroscopy of propagating spin waves in micrometer sized thin magnetic stripes. The magnetostatic surface spin waves are excited and detected by scaled down to 125 nm wide inductive antennas, which award ultra broadband wavevector capability. The wavevector selection can be done by applying an excitation frequency above the ferromagnetic resonance. Wavevector demultiplexing is done at the spin wave detector thanks to the rotation of the spin wave phase upon propagation. A simple model accounts for the main features of the apparatus transfer functions. Our approach opens an avenue for themore » all electrical study of wavevector-dependent spin wave properties including dispersion spectra or non-reciprocal propagation.« less

Development of an Autonomous Broadband Acoustic Scattering System for Remote Characterization of Zooplankton

DTIC Science & Technology

2009-01-01

measure of a backscatter at a single narrowband frequency, and some AUVs carry single-frequency sidescan sonars (and this technology has been adapted...monostatic Doppler sonar module. Key personnel for this project include: Andone Lavery as the PI for this project and who has overall responsibility...for the successful development, testing, and calibration of the broadband system. Gene Terray, who developed the original sonar Doppler sonar boards

Broadband Studies of Semsmic Sources at Regional and Teleseismic Distances Using Advanced Time Series Analysis Methods. Volume 1.

DTIC Science & Technology

1991-03-21

discussion of spectral factorability and motivations for broadband analysis, the report is subdivided into four main sections. In Section 1.0, we...estimates. The motivation for developing our multi-channel deconvolution method was to gain information about seismic sources, most notably, nuclear...with complex constraints for estimating the rupture history. Such methods (applied mostly to data sets that also include strong rmotion data), were

Omnidirectional, broadband light absorption using large-area, ultrathin lossy metallic film coatings

NASA Astrophysics Data System (ADS)

Li, Zhongyang; Palacios, Edgar; Butun, Serkan; Kocer, Hasan; Aydin, Koray

2015-10-01

Resonant absorbers based on nanostructured materials are promising for variety of applications including optical filters, thermophotovoltaics, thermal emitters, and hot-electron collection. One of the significant challenges for such micro/nanoscale featured medium or surface, however, is costly lithographic processes for structural patterning which restricted from industrial production of complex designs. Here, we demonstrate lithography-free, broadband, polarization-independent optical absorbers based on a three-layer ultrathin film composed of subwavelength chromium (Cr) and oxide film coatings. We have measured almost perfect absorption as high as 99.5% across the entire visible regime and beyond (400-800 nm). In addition to near-ideal absorption, our absorbers exhibit omnidirectional independence for incidence angle over ±60 degrees. Broadband absorbers introduced in this study perform better than nanostructured plasmonic absorber counterparts in terms of bandwidth, polarization and angle independence. Improvements of such “blackbody” samples based on uniform thin-film coatings is attributed to extremely low quality factor of asymmetric highly-lossy Fabry-Perot cavities. Such broadband absorber designs are ultrathin compared to carbon nanotube based black materials, and does not require lithographic processes. This demonstration redirects the broadband super absorber design to extreme simplicity, higher performance and cost effective manufacturing convenience for practical industrial production.

Exhaled breath profiling using broadband quantum cascade laser-based spectroscopy in healthy children and children with asthma and cystic fibrosis.

PubMed

van Mastrigt, E; Reyes-Reyes, A; Brand, K; Bhattacharya, N; Urbach, H P; Stubbs, A P; de Jongste, J C; Pijnenburg, M W

2016-04-08

Exhaled breath analysis is a potential non-invasive tool for diagnosing and monitoring airway diseases. Gas chromatography-mass spectrometry and electrochemical sensor arrays are the main techniques to detect volatile organic compounds (VOC) in exhaled breath. We developed a broadband quantum cascade laser spectroscopy technique for VOC detection and identification. The objective of this study was to assess the repeatability of exhaled breath profiling with broadband quantum cascade laser-based spectroscopy and to explore the clinical applicability by comparing exhaled breath samples from healthy children with those from children with asthma or cystic fibrosis (CF). Healthy children and children with stable asthma or stable CF, aged 6-18 years, were included. Two to four exhaled breath samples were collected in Tedlar bags and analyzed by quantum cascade laser spectroscopy to detect VOCs with an absorption profile in the wavenumber region between 832 and 1262.55 cm(-1). We included 35 healthy children, 39 children with asthma and 15 with CF. Exhaled breath VOC profiles showed poor repeatability (Spearman's rho  =  0.36 to 0.46) and agreement of the complete profiles. However, we were able to discriminate healthy children from children with stable asthma or stable CF and identified VOCs that were responsible for this discrimination. Broadband quantum cascade laser-based spectroscopy detected differences in VOC profiles in exhaled breath samples between healthy children and children with asthma or CF. The combination of a relatively easy and fast method and the possibility of molecule identification makes broadband quantum cascade laser-based spectroscopy attractive to investigate the diagnostic and prognostic potential of volatiles in exhaled breath.

The Central and Eastern U.S. Seismic Network: Legacy of USArray

NASA Astrophysics Data System (ADS)

Eakins, J. A.; Astiz, L.; Benz, H.; Busby, R. W.; Hafner, K.; Reyes, J. C.; Sharer, G.; Vernon, F.; Woodward, R.

2014-12-01

As the USArray Transportable Array entered the central and eastern United States, several Federal agencies (National Science Foundation, U.S. Geological Survey, U.S. Nuclear Regulatory Commission, and Department of Energy) recognized the unique opportunity to retain TA stations beyond the original timeline. The mission of the CEUSN is to produce data that enables researchers and Federal agencies alike to better understand the basic geologic questions, background earthquake rates and distribution, seismic hazard potential, and associated societal risks of this region. The selected long-term sub-array from Transportable Array (TA) stations includes nearly 200 sites, complemented by 100 broadband stations from the existing regional seismic networks to form the Central and Eastern United States Network (CEUSN). Multiple criteria for site selection were weighed by an inter-agency TA Station Selection (TASS) Working Group: seismic noise characteristics, data availability in real time, proximity to nuclear power plants, and homogeneous distribution throughout the region. The Array Network Facility (ANF) started collecting data for CEUSN network stations since late 2013, with all stations collected since May 2014. Regional seismic data streams are collected in real-time from the IRIS Data Management Center (DMC). TA stations selected to be part of CEUSN, retain the broadband sensor to which a 100 sps channel is added, the infrasound and environmental channels, and, at some stations, accelerometers are deployed. The upgraded sites become part of the N4 network for which ANF provides metadata and can issue remote commands to the station equipment. Stations still operated by TA, but planned for CEUSN, are included in the virtual network so all stations are currently available now. By the end of 2015, the remaining TA stations will be upgraded. Data quality control procedures developed for TA stations at ANF and at the DMC are currently performed on N4 data. However, teleseismic and regional events are only picked a few times a month to fulfill data quality checks on the data. The assembled CEUSN data sets can be requested from the DMC with the _CEUSN virtual network code. Acknowledgments to Seismic Regional Network Operators: C. Ammon, J. Ebel, D. Doser, R. Hermann, A. Holland, W-Y. Kim, C. Langston, T. Owens, and M. Withers.

Strategy for the deployment of a dense broadband temporary array in the Alps: lessons learnt from the CIFALPS experiment

NASA Astrophysics Data System (ADS)

Coralie, Aubert; Anne, Paul; Stefano, Solarino; Sandrine, Roussel; Simone, Salimbeni; Pierre, Zangelmi; Glenn, Cougoulat; Yinshuang, Ai; Weiwei, Xu; Yumei, He; Liang, Zhao

2013-04-01

The CIFALPS (China-Italy-France Alps seismic survey) experiment is a common project of IGGCAS (China), ISTerre (France) and INGV (Italy). It aims at getting new high-resolution passive seismic data on the crustal and upper mantle structure of the southwestern Alps. In this framework, we have installed a temporary broadband seismic array across the southwestern Alps from the Rhône valley (France) to the Po plain (Italy). The main sub-array of CIFALPS is a 350-km long roughly linear profile of 46 stations trending WSW-ENE from Bollène (France) to north of Alessandria (Italy). The average station spacing is 10 km in the outer parts of the belt, and it reduces to 5 km in the internal Alps. Nine additional temporary stations located ~40 km to the north and south of the main profile complement the permanent broadband networks to improve the 3-D constraints on the deep structures. Stations are equipped with Nanometrics Taurus data acquisition systems, and Trillium 120P/A, CMG3-ESP or CMG40T broadband sensors. The array was installed in the summer of 2012 and will be operated at least to April 2013. Because our schedule was tight, we had to achieve site selections in only 3-4 months in spite of strong constraints on site location related to short interstation spacing. Most sites are located in basements of buildings for security reasons and mains power supply. As most sensors are true broadband (90s or 120s), we put much effort on vault design to insure good thermal insulation and low noise at long periods. The vaults also had to be easily and rapidly built and they should be easily and totally removed at the end of the experiment. We used the PQLX software for quality control of our sites and vault design. The performances of our vaults are good for the vertical component with noise levels at 100s period in the range -185 dB (low noise model) to -165 dB. They are less good for horizontal components (noise level close to high noise model at periods > 20s) due to atmospheric pressure and temperature variations. Stations located outside buildings do not have better performances at 100s than stations located in basements. Two of our six stations installed outside buildings are prone to mass centering problems due to tilting of the concrete slab in soft soil. For state-of-health control and data transmission, we are testing 2G and 3G communication modems at 4 remote stations but with limited success. Database preparation and management benefitted from the expertise of engineers of the seismic datacenter of ISTerre. The experience gained on all technical aspects of a temporary experiment will provide valuable input for the preparation of the future AlpArray project.

Complement Activation in Inflammatory Skin Diseases

PubMed Central

Giang, Jenny; Seelen, Marc A. J.; van Doorn, Martijn B. A.; Rissmann, Robert; Prens, Errol P.; Damman, Jeffrey

2018-01-01

The complement system is a fundamental part of the innate immune system, playing a crucial role in host defense against various pathogens, such as bacteria, viruses, and fungi. Activation of complement results in production of several molecules mediating chemotaxis, opsonization, and mast cell degranulation, which can contribute to the elimination of pathogenic organisms and inflammation. Furthermore, the complement system also has regulating properties in inflammatory and immune responses. Complement activity in diseases is rather complex and may involve both aberrant expression of complement and genetic deficiencies of complement components or regulators. The skin represents an active immune organ with complex interactions between cellular components and various mediators. Complement involvement has been associated with several skin diseases, such as psoriasis, lupus erythematosus, cutaneous vasculitis, urticaria, and bullous dermatoses. Several triggers including auto-antibodies and micro-organisms can activate complement, while on the other hand complement deficiencies can contribute to impaired immune complex clearance, leading to disease. This review provides an overview of the role of complement in inflammatory skin diseases and discusses complement factors as potential new targets for therapeutic intervention. PMID:29713318

Out Flying the Eagle: China’s Drive for Domestic Economic Innovation and Its Impact on U.S.-China Relations

DTIC Science & Technology

2014-03-01

wind turbines from General Electric. China recognizes the issues with IPR but it is something that will take time to fix. It will be a significant...Large aircraft  Large-scale oil and gas exploration  Manned space, including lunar exploration  Next-generation broadband wireless ...circuits, and building an innovation system for China’s integrated circuit (IC) manufacturing industry. 3. New generation broadband wireless mobile

Broadband optical antireflection enhancement by integrating antireflective nanoislands with silicon nanoconical-frustum arrays.

PubMed

Park, Haesung; Shin, Dongheok; Kang, Gumin; Baek, Seunghwa; Kim, Kyoungsik; Padilla, Willie J

2011-12-22

Based on conventional colloidal nanosphere lithography, we experimentally demonstrate novel graded-index nanostructures for broadband optical antireflection enhancement including the near-ultraviolet (NUV) region by integrating residual polystyrene antireflective (AR) nanoislands coating arrays with silicon nano-conical-frustum arrays. This is a feasible optimized integration method of two major approaches for antireflective surfaces: quarter-wavelength AR coating and biomimetic moth's eye structure. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Broadband All-angle Negative Refraction by Optimized Phononic Crystals.

PubMed

Li, Yang Fan; Meng, Fei; Zhou, Shiwei; Lu, Ming-Hui; Huang, Xiaodong

2017-08-07

All-angle negative refraction (AANR) of phononic crystals and its frequency range are dependent on mechanical properties of constituent materials and their spatial distribution. So far, it is impossible to achieve the maximum operation frequency range of AANR theoretically. In this paper, we will present a numerical approach for designing a two-dimensional phononic crystal with broadband AANR without negative index. Through analyzing the mechanism of AANR, a topology optimization problem aiming at broadband AANR is established and solved by bi-directional evolutionary structural optimization method. The optimal steel/air phononic crystal exhibits a record AANR range over 20% and its refractive properties and focusing effects are further investigated. The results demonstrate the multifunctionality of a flat phononic slab including superlensing effect near upper AANR frequencies and self-collimation at lower AANR frequencies.

A broadband Soleil-Babinet compensator for ultrashort light pulses

NASA Astrophysics Data System (ADS)

Xu, Shixiang; Ma, Yingkun; Cai, Yi; Lu, Xiaowei; Zeng, Xuanke; Chen, Hongyi; Li, Jingzhen

2013-12-01

This letter reports a novel design for a broadband Soleil-Babinet compensator including two pairs of optical wedges plus one plate. According to our birefringent dispersion compensation model, we can eliminate the first-order birefringent phase retardation (BPR) dispersion by using three different birefringent crystals. Our results show a Soleil-Babinet compensator based on a MgF2/ADP/KDP combination can work from 0° to 360° phase compensation with the maximal residual BPR less than 6° within the spectral region from 0.65 to 0.95 μm. The residual BPR of the compensator increases monotonically with the spectral deviation from the designed central wavelength, so our compensator is very suitable to be used for broadband laser pulses with most of their energies around the central wavelengths.

47 CFR 27.1217 - Competitive bidding procedures for the Broadband Radio Service.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Broadband Radio Service. 27.1217 Section 27.1217 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1217 Competitive bidding procedures for the Broadband Radio...

47 CFR 27.1217 - Competitive bidding procedures for the Broadband Radio Service.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Broadband Radio Service. 27.1217 Section 27.1217 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1217 Competitive bidding procedures for the Broadband Radio...

47 CFR 27.1217 - Competitive bidding procedures for the Broadband Radio Service.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Broadband Radio Service. 27.1217 Section 27.1217 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1217 Competitive bidding procedures for the Broadband Radio...

47 CFR 27.1217 - Competitive bidding procedures for the Broadband Radio Service.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Broadband Radio Service. 27.1217 Section 27.1217 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1217 Competitive bidding procedures for the Broadband Radio...

The Complement System in Dialysis: A Forgotten Story?

PubMed Central

Poppelaars, Felix; Faria, Bernardo; Gaya da Costa, Mariana; Franssen, Casper F. M.; van Son, Willem J.; Berger, Stefan P.; Daha, Mohamed R.; Seelen, Marc A.

2018-01-01

Significant advances have lead to a greater understanding of the role of the complement system within nephrology. The success of the first clinically approved complement inhibitor has created renewed appreciation of complement-targeting therapeutics. Several clinical trials are currently underway to evaluate the therapeutic potential of complement inhibition in renal diseases and kidney transplantation. Although, complement has been known to be activated during dialysis for over four decades, this area of research has been neglected in recent years. Despite significant progress in biocompatibility of hemodialysis (HD) membranes and peritoneal dialysis (PD) fluids, complement activation remains an undesired effect and relevant issue. Short-term effects of complement activation include promoting inflammation and coagulation. In addition, long-term complications of dialysis, such as infection, fibrosis and cardiovascular events, are linked to the complement system. These results suggest that interventions targeting the complement system in dialysis could improve biocompatibility, dialysis efficacy, and long-term outcome. Combined with the clinical availability to safely target complement in patients, the question is not if we should inhibit complement in dialysis, but when and how. The purpose of this review is to summarize previous findings and provide a comprehensive overview of the role of the complement system in both HD and PD. PMID:29422906

Color discrimination with broadband photoreceptors.

PubMed

Schnaitmann, Christopher; Garbers, Christian; Wachtler, Thomas; Tanimoto, Hiromu

2013-12-02

Color vision is commonly assumed to rely on photoreceptors tuned to narrow spectral ranges. In the ommatidium of Drosophila, the four types of so-called inner photoreceptors express different narrow-band opsins. In contrast, the outer photoreceptors have a broadband spectral sensitivity and were thought to exclusively mediate achromatic vision. Using computational models and behavioral experiments, we demonstrate that the broadband outer photoreceptors contribute to color vision in Drosophila. The model of opponent processing that includes the opsin of the outer photoreceptors scored the best fit to wavelength discrimination data. To experimentally uncover the contribution of individual photoreceptor types, we restored phototransduction of targeted photoreceptor combinations in a blind mutant. Dichromatic flies with only broadband photoreceptors and one additional receptor type can discriminate different colors, indicating the existence of a specific output comparison of the outer and inner photoreceptors. Furthermore, blocking interneurons postsynaptic to the outer photoreceptors specifically impaired color but not intensity discrimination. Our findings show that receptors with a complex and broad spectral sensitivity can contribute to color vision and reveal that chromatic and achromatic circuits in the fly share common photoreceptors. Copyright © 2013 Elsevier Ltd. All rights reserved.

On the Solar Chromosphere Observed at the LIMB with Hinode

NASA Astrophysics Data System (ADS)

Judge, Philip G.; Carlsson, Mats

2010-08-01

Broadband images in the Ca II H line, from the Broadband Filter Imager (BFI) instrument on the Hinode spacecraft, show emission from spicules emerging from and visible right down to the observed limb. Surprisingly, little absorption of spicule light is seen along their lengths. We present formal solutions to the transfer equation for given (ad hoc) source functions, including a stratified chromosphere from which spicules emanate. The model parameters are broadly compatible with earlier studies of spicules. The visibility of Ca II spicules down to the limb in Hinode data seems to require that spicule emission be Doppler shifted relative to the stratified atmosphere, either by supersonic turbulent or organized spicular motion. The non-spicule component of the chromosphere is almost invisible in the broadband BFI data, but we predict that it will be clearly visible in high spectral resolution data. Broadband Ca II H limb images give the false impression that the chromosphere is dominated by spicules. Our analysis serves as a reminder that the absence of a signature can be as significant as its presence.

A multidisciplinary monitoring network at Mayon volcano, Philippines: A collaborative effort between PHIVOLCS and EOS

NASA Astrophysics Data System (ADS)

Schwandner, F. M.; Hidayat, D.; Laguerta, E. P.; Baloloy, A. V.; Valerio, R.; Vaquilar, R.; Arpa, M. C.; Marcial, S. S.; Novianti, M. L.

2012-04-01

Mount Mayon in Albay province (Philippines) is an openly-degassing basaltic-andesitic stratovolcano, located on the northern edge of the northwest-trending OAS graben. Its latest eruptions were in Aug-Sept 2006 and Dec 2009. Mayon's current status is PHIVOLCS' level 1 with low seismicity dominated mostly local and regional tectonic earthquakes and continuous emission of SO2 from its summit crater. A research collaboration between the Earth Observatory of Singapore-NTU and the Philippine Institute of Volcanology and Seismology (PHIVOLCS) was initiated in 2009, aimed at developing a multi-disciplinary monitoring network around Mayon. The network design comprises a network of co-located geophysical, geochemical, hydrological and meteorological sensors, in both radial and circular arrangements. Radially arranged stations are intended to capture and distinguish vertical conduit processes, while the circular station design (including existing PHIVOLCS stations in cooperation with JICA, Japan) is meant to distinguish locations and sector activity of subsurface events. Geophysical instrumentation from EOS currently includes 4 broadband seismographs (in addition to 3 existing broadbands and 3 short period instruments from PHIVOLCS & JICA), and 5 tiltmeters. Four continuous cGPS stations will be installed in 2012, complementing 5 existing PHIVOLCS stations. Stations are also designed to house a multi-sensor package of static subsurface soil CO2 monitoring stations, the first of which was installed in early 2012, and which include subsoil sensors for heat flux, temperature, and moisture, as well as meteorological stations (with sonic anemometers and contact rain gages). These latter sensors are all controlled from one control box per station. Meteorological stations will help us to validate tilt, gas permeability, and also know lahar initiation potential. Since early 2011, separate stations downwind of the two prevailing wind directions from the summit continuously monitor the SO2 plume during daylight (the first Asian NOVAC dual-channel mini-DOAS). One unused agricultural well and one boxed spring were equipped with multi-sensor probes, installed in spring and summer 2011, to detect bulk volumetric strain and changes in chemical composition in high-gain and low-gain mode. All stations are autonomous in terms of their power source (solar), and are designed to withstand typhoons, break-in attempts and direct/indirect lightning strikes. To telemeter the data from these instruments to the local PHIVOLCS observatory at Lignon Hill (Legazpi), we use spread-spectrum radios with our own repeater stations, GSM/GPRS radio modems, and 3G broadband Internet. High rate data including seismic and NOVAC SO2 data are transmitted via spread-spectrum radio, whereas tilt, ground CO2, meteorology, hydrology and soil parameters are transmitted via 3G and SMS. We designed a low-cost datalogger system, which has been operating since Jan 2011, performing continuous data acquisition with sampling rate of 20 minute/sample and transmitted through GSM network, for tilt data. The receiving station is the PHIVOLCS Lignon Hill Observatory (LHO), where an off-grid power system has been installed to ensure continuous operation of the monitoring computers and radios. Local pre-processing by observatory staff and local archiving ensures close to immediate availability of data products in times of crisis. The data are also forwarded via TCP/IP to servers at PHIVOLCS headquarters and at EOS. Network infrastructure and data flows will be completed in 2012.

First multi-wavelength campaign on the gamma-ray-loud active galaxy IC 310

NASA Astrophysics Data System (ADS)

Ahnen, M. L.; Ansoldi, S.; Antonelli, L. A.; Arcaro, C.; Babić, A.; Banerjee, B.; Bangale, P.; Barres de Almeida, U.; Barrio, J. A.; Becerra González, J.; Bednarek, W.; Bernardini, E.; Berti, A.; Biasuzzi, B.; Biland, A.; Blanch, O.; Bonnefoy, S.; Bonnoli, G.; Borracci, F.; Bretz, T.; Carosi, R.; Carosi, A.; Chatterjee, A.; Colin, P.; Colombo, E.; Contreras, J. L.; Cortina, J.; Covino, S.; Cumani, P.; Da Vela, P.; Dazzi, F.; De Angelis, A.; De Lotto, B.; de Oña Wilhelmi, E.; Di Pierro, F.; Doert, M.; Domínguez, A.; Dominis Prester, D.; Dorner, D.; Doro, M.; Einecke, S.; Eisenacher Glawion, D.; Elsaesser, D.; Engelkemeier, M.; Fallah Ramazani, V.; Fernández-Barral, A.; Fidalgo, D.; Fonseca, M. V.; Font, L.; Fruck, C.; Galindo, D.; García López, R. J.; Garczarczyk, M.; Gaug, M.; Giammaria, P.; Godinović, N.; Gora, D.; Guberman, D.; Hadasch, D.; Hahn, A.; Hassan, T.; Hayashida, M.; Herrera, J.; Hose, J.; Hrupec, D.; Hughes, G.; Idec, W.; Ishio, K.; Kodani, K.; Konno, Y.; Kubo, H.; Kushida, J.; Lelas, D.; Lindfors, E.; Lombardi, S.; Longo, F.; López, M.; Majumdar, P.; Makariev, M.; Mallot, K.; Maneva, G.; Manganaro, M.; Mannheim, K.; Maraschi, L.; Mariotti, M.; Martínez, M.; Mazin, D.; Menzel, U.; Mirzoyan, R.; Moralejo, A.; Moretti, E.; Nakajima, D.; Neustroev, V.; Niedzwiecki, A.; Nievas Rosillo, M.; Nilsson, K.; Nishijima, K.; Noda, K.; Nogués, L.; Nöthe, M.; Paiano, S.; Palacio, J.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Paredes-Fortuny, X.; Pedaletti, G.; Peresano, M.; Perri, L.; Persic, M.; Poutanen, J.; Prada Moroni, P. G.; Prandini, E.; Puljak, I.; Garcia, J. R.; Reichardt, I.; Rhode, W.; Ribó, M.; Rico, J.; Saito, T.; Satalecka, K.; Schroeder, S.; Schweizer, T.; Shore, S. N.; Sillanpää, A.; Sitarek, J.; Snidaric, I.; Sobczynska, D.; Stamerra, A.; Strzys, M.; Surić, T.; Takalo, L.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Tescaro, D.; Teshima, M.; Torres, D. F.; Torres-Albà, N.; Toyama, T.; Treves, A.; Vanzo, G.; Vazquez Acosta, M.; Vovk, I.; Ward, J. E.; Will, M.; Wu, M. H.; Krauß, F.; Schulz, R.; Kadler, M.; Wilms, J.; Ros, E.; Bach, U.; Beuchert, T.; Langejahn, M.; Wendel, C.; Gehrels, N.; Baumgartner, W. H.; Markwardt, C. B.; Müller, C.; Grinberg, V.; Hovatta, T.; Magill, J.

2017-07-01

Context. The extragalactic very-high-energy gamma-ray sky is rich in blazars. These are jetted active galactic nuclei that are viewed at a small angle to the line-of-sight. Only a handful of objects viewed at a larger angle are so far known to emit above 100 GeV. Multi-wavelength studies of such objects up to the highest energies provide new insights into the particle and radiation processes of active galactic nuclei. Aims: We aim to report the results from the first multi-wavelength campaign observing the TeV detected nucleus of the active galaxy IC 310, whose jet is observed at a moderate viewing angle of 10°-20°. Methods: The multi-instrument campaign was conducted between 2012 November and 2013 January, and involved observations with MAGIC, Fermi, INTEGRAL, Swift, OVRO, MOJAVE and EVN. These observations were complemented with archival data from the AllWISE and 2MASS catalogs. A one-zone synchrotron self-Compton model was applied to describe the broadband spectral energy distribution. Results: IC 310 showed an extraordinary TeV flare at the beginning of the campaign, followed by a low, but still detectable TeV flux. Compared to previous measurements in this energy range, the spectral shape was found to be steeper during the low emission state. Simultaneous observations in the soft X-ray band showed an enhanced energy flux state and a harder-when-brighter spectral shape behavior. No strong correlated flux variability was found in other frequency regimes. The broadband spectral energy distribution obtained from these observations supports the hypothesis of a double-hump structure. Conclusions: The harder-when-brighter trend in the X-ray and VHE emission, observed for the first time during this campaign, is consistent with the behavior expected from a synchrotron self-Compton scenario. The contemporaneous broadband spectral energy distribution is well described with a one-zone synchrotron self-Compton model using parameters that are comparable to those found for other gamma-ray-emitting misaligned blazars.

Combination of broadband diffuse optical spectroscopy with magnetic resonance imaging

NASA Astrophysics Data System (ADS)

Merritt, Sean Isaiah

Broadband diffuse optical spectroscopy (DOS) is an emerging optical technique used to measure absorption and scattering of bulk tissue non-invasively within the near-infrared (600--1050 nm). The ultimate aim of my advisors group is for broadband DOS to become an established medical diagnostic technique used clinically on various tissue types including breast, muscle and bone. The specific goal for my research is to use established magnetic resonance (MR) techniques for the purpose of continued development and validation of broadband DOS. The initial studies carried out were a validation of broadband DOS through a direct comparison with MRI. Both techniques are sensitive to signals produced by water and lipids in tissue. There is also sensitivity to blood flow, which MRI measures using exogenous contrast agents and broadband DOS is sensitive through measurement of total hemoglobin content (THC) and tissue oxygen saturation (StO2). These validation studies were compared initially in a rat tumor model in which both techniques were used simultaneously. A qualitative correlation was found between the MR images of water content and blood perfusion compared with the DOS water and THC values. A more quantitative comparison was made between measuring absolute water and lipid content in phantoms and in human tissue, which showed a strong correlation. The in vivo study also validated that broadband DOS was interrogating bone marrow in the tibia. The second half of this thesis is focused on developing new capabilities of broadband DOS and the MRI literature is used as a guide. When a water molecule hydrogen bonds to another molecule, the absorption spectrum in the near-infrared which is due to the vibrational overtone of the OH bond will change. The expected changes were observed in tissue and an algorithm was developed to fit for a tissue bound water parameter. Also, as tissue temperature changes, the fraction of water bound to other water molecules changes and can be used to fit for deep tissue temperature. Preliminary validation of these two techniques is carried out and there appears to be great potential for these methods.

Generation of Viable Mice from Induced Pluripotent Stem Cells (iPSCs) Through Tetraploid Complementation.

PubMed

Kang, Lan; Gao, Shaorong

2015-01-01

Tetraploid complementation assay is the most rigorous criteria for pluripotency characterization of pluripotent stem cells including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Pluripotent stem cells could complement the developmental deficiency of tetraploid embryos and thus support the full-term mice development. Here we describe the protocol for tetraploid complementation using iPSCs to produce viable all-iPSC mice.

Breaking down the complement system: a review and update on novel therapies.

PubMed

Reddy, Yuvaram N V; Siedlecki, Andrew M; Francis, Jean M

2017-03-01

The complement system represents one of the more primitive forms of innate immunity. It has increasingly been found to contribute to pathologies in the native and transplanted kidney. We provide a concise review of the physiology of the complement cascade, and discuss current and upcoming complement-based therapies. Current agents in clinical use either bind to complement components directly or prevent complement from binding to antibodies affixed to the endothelial surface. These include C1 esterase inhibitors, anti-C5 mAbs, anti-CD20 mAbs, and proteasome inhibitors. Treatment continues to show efficacy in the atypical hemolytic uremic syndrome and antibody-mediated rejection. Promising agents not currently available include CCX168, TP10, AMY-101, factor D inhibitors, coversin, and compstatin. Several new trials are targeting complement inhibition to treat antineutrophilic cystoplasmic antibody (ANCA)-associated vasculitis, C3 glomerulopathy, thrombotic microangiopathy, and IgA nephropathy. New agents for the treatment of the atypical hemolytic uremic syndrome are also in development. Complement-based therapies are being considered for targeted therapy in the atypical hemolytic uremic syndrome and antibody-mediated rejection, C3 glomerulopathy, and ANCA-associated vasculitis. A few agents are currently in use as orphan drugs. A number of other drugs are in clinical trials and, overall, are showing promising preliminary results.

New Spectral Model for Constraining Torus Covering Factors from Broadband X-Ray Spectra of Active Galactic Nuclei

NASA Astrophysics Data System (ADS)

Baloković, M.; Brightman, M.; Harrison, F. A.; Comastri, A.; Ricci, C.; Buchner, J.; Gandhi, P.; Farrah, D.; Stern, D.

2018-02-01

The basic unified model of active galactic nuclei (AGNs) invokes an anisotropic obscuring structure, usually referred to as a torus, to explain AGN obscuration as an angle-dependent effect. We present a new grid of X-ray spectral templates based on radiative transfer calculations in neutral gas in an approximately toroidal geometry, appropriate for CCD-resolution X-ray spectra (FWHM ≥ 130 eV). Fitting the templates to broadband X-ray spectra of AGNs provides constraints on two important geometrical parameters of the gas distribution around the supermassive black hole: the average column density and the covering factor. Compared to the currently available spectral templates, our model is more flexible, and capable of providing constraints on the main torus parameters in a wider range of AGNs. We demonstrate the application of this model using hard X-ray spectra from NuSTAR (3–79 keV) for four AGNs covering a variety of classifications: 3C 390.3, NGC 2110, IC 5063, and NGC 7582. This small set of examples was chosen to illustrate the range of possible torus configurations, from disk-like to sphere-like geometries with column densities below, as well as above, the Compton-thick threshold. This diversity of torus properties challenges the simple assumption of a standard geometrically and optically thick toroidal structure commonly invoked in the basic form of the unified model of AGNs. Finding broad consistency between our constraints and those from infrared modeling, we discuss how the approach from the X-ray band complements similar measurements of AGN structures at other wavelengths.

On-board processing satellite network architectures for broadband ISDN

NASA Technical Reports Server (NTRS)

Inukai, Thomas; Faris, Faris; Shyy, Dong-Jye

1992-01-01

Onboard baseband processing architectures for future satellite broadband integrated services digital networks (B-ISDN's) are addressed. To assess the feasibility of implementing satellite B-ISDN services, critical design issues, such as B-ISDN traffic characteristics, transmission link design, and a trade-off between onboard circuit and fast packet switching, are analyzed. Examples of the two types of switching mechanisms and potential onboard network control functions are presented. A sample network architecture is also included to illustrate a potential onboard processing system.

47 CFR 27.1305 - Shared wireless broadband network.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 2 2010-10-01 2010-10-01 false Shared wireless broadband network. 27.1305... broadband network. The Shared Wireless Broadband Network developed by the 700 MHz Public/Private Partnership must be designed to meet requirements associated with a nationwide, public safety broadband network. At...

47 CFR 90.1405 - Shared wireless broadband network.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Shared wireless broadband network. 90.1405... broadband network. The Shared Wireless Broadband Network developed by the 700 MHz Public/Private Partnership must be designed to meet requirements associated with a nationwide, public safety broadband network. At...

47 CFR 27.1305 - Shared wireless broadband network.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 2 2011-10-01 2011-10-01 false Shared wireless broadband network. 27.1305... broadband network. The Shared Wireless Broadband Network developed by the 700 MHz Public/Private Partnership must be designed to meet requirements associated with a nationwide, public safety broadband network. At...

47 CFR 90.1405 - Shared wireless broadband network.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Shared wireless broadband network. 90.1405... broadband network. The Shared Wireless Broadband Network developed by the 700 MHz Public/Private Partnership must be designed to meet requirements associated with a nationwide, public safety broadband network. At...

47 CFR 27.1305 - Shared wireless broadband network.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 2 2012-10-01 2012-10-01 false Shared wireless broadband network. 27.1305... broadband network. The Shared Wireless Broadband Network developed by the 700 MHz Public/Private Partnership must be designed to meet requirements associated with a nationwide, public safety broadband network. At...

47 CFR 90.1405 - Shared wireless broadband network.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 47 Telecommunication 5 2012-10-01 2012-10-01 false Shared wireless broadband network. 90.1405... broadband network. The Shared Wireless Broadband Network developed by the 700 MHz Public/Private Partnership must be designed to meet requirements associated with a nationwide, public safety broadband network. At...

78 FR 54241 - Proposed Information Collection; Comment Request; BroadbandMatch Web Site Tool

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-03

... Information Collection; Comment Request; BroadbandMatch Web Site Tool AGENCY: National Telecommunications and... goal of increased broadband deployment and use in the United States. The BroadbandMatch Web site began... empowering technology effectively. II. Method of Collection BroadbandMatch users access the Web site through...

46 CFR 252.31 - Wages of officers and crews.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Subsidy Rates § 252.31 Wages of officers and crews. (a) Definitions. When used in this part: (1) Base... the employment of the approved manning complement of the subsidized vessel, including payments... governmental assessments on crew payrolls. (4) Approved manning complement means the complement approved by the...

Broadband quantitative phase microscopy with extended field of view using off-axis interferometric multiplexing.

PubMed

Girshovitz, Pinhas; Frenklach, Irena; Shaked, Natan T

2015-11-01

We propose a new portable imaging configuration that can double the field of view (FOV) of existing off-axis interferometric imaging setups, including broadband off-axis interferometers. This configuration is attached at the output port of the off-axis interferometer and optically creates a multiplexed interferogram on the digital camera, which is composed of two off-axis interferograms with straight fringes at orthogonal directions. Each of these interferograms contains a different FOV of the imaged sample. Due to the separation of these two FOVs in the spatial-frequency domain, they can be fully reconstructed separately, while obtaining two complex wavefronts from the sample at once. Since the optically multiplexed off-axis interferogram is recorded by the camera in a single exposure, fast dynamics can be recorded with a doubled imaging area. We used this technique for quantitative phase microscopy of biological samples with extended FOV. We demonstrate attaching the proposed module to a diffractive phase microscopy interferometer, illuminated by a broadband light source. The biological samples used for the experimental demonstrations include microscopic diatom shells, cancer cells, and flowing blood cells.

Experimental investigation of an inversion technique for the determination of broadband duct mode amplitudes by the use of near-field sensor arrays.

PubMed

Castres, Fabrice O; Joseph, Phillip F

2007-08-01

This paper is an experimental investigation of an inverse technique for deducing the amplitudes of the modes radiated from a turbofan engine, including schemes for stablizing the solution. The detection of broadband modes generated by a laboratory-scaled fan inlet is performed using a near-field array of microphones arranged in a geodesic geometry. This array geometry is shown to allow a robust and accurate modal inversion. The sound power radiated from the fan inlet and the coherence function between different modal amplitudes are also presented. The knowledge of such modal content is useful in helping to characterize the source mechanisms of fan broadband noise generation, for determining the most appropriate mode distribution model for duct liner predictions, and for making sound power measurements of the radiated sound field.

76 FR 10295 - Implementing a Nationwide, Broadband, Interoperable Public Safety Network in the 700 MHz Band

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-24

... Docket 07-100; FCC 11-6] Implementing a Nationwide, Broadband, Interoperable Public Safety Network in the... framework for the nationwide public safety broadband network. This document considers and proposes... broadband networks operating in the 700 MHz band. This document addresses public safety broadband network...

Validation of Improved Broadband Shortwave and Longwave Fluxes Derived From GOES

NASA Technical Reports Server (NTRS)

Khaiyer, Mandana M.; Nordeen, Michele L.; Palikonda, Rabindra; Yi, Yuhong; Minnis, Patrick; Doelling, David R.

2009-01-01

Broadband (BB) shortwave (SW) and longwave (LW) fluxes at TOA (Top of Atmosphere) are crucial parameters in the study of climate and can be monitored over large portions of the Earth's surface using satellites. The VISST (Visible Infrared Solar Split-Window Technique) satellite retrieval algorithm facilitates derivation of these parameters from the Geostationery Operational Environmental Satellites (GOES). However, only narrowband (NB) fluxes are available from GOES, so this derivation requires use of narrowband-to-broadband (NB-BB) conversion coefficients. The accuracy of these coefficients affects the validity of the derived broadband (BB) fluxes. Most recently, NB-BB fits were re-derived using the NB fluxes from VISST/GOES data with BB fluxes observed by the CERES (Clouds and the Earth's Radiant Energy Budget) instrument aboard Terra, a sun-synchronous polar-orbiting satellite that crosses the equator at 10:30 LT. Subsequent comparison with ARM's (Atmospheric Radiation Measurement) BBHRP (Broadband Heating Rate Profile) BB fluxes revealed that while the derived broadband fluxes agreed well with CERES near the Terra overpass times, the accuracy of both LW and SW fluxes decreased farther away from the overpass times. Terra's orbit hampers the ability of the NB-BB fits to capture diurnal variability. To account for this in the LW, seasonal NB-BB fits are derived separately for day and night. Information from hourly SW BB fluxes from the Meteosat-8 Geostationary Earth Radiation Budget (GERB) is employed to include samples over the complete solar zenith angle (SZA) range sampled by Terra. The BB fluxes derived from these improved NB-BB fits are compared to BB fluxes computed with a radiative transfer model.

Usability of ocean-bottom seismograms for broadband waveform tomography

NASA Astrophysics Data System (ADS)

Eibl, Eva P. S.; Sigloch, Karin

2013-04-01

Recordings made by broadband seismometers on the ocean-bottom are generally noisier than recordings of land stations using the same sensor type. The primary reason is that oceanic recordings are more affected by microseismic noise, which originates in the oceans. A similar drawback applies to data from stations on oceanic islands. The frequency band between 0.05 Hz and 0.2 Hz is most affected by microseismic noise -- unfortunately a large overlap with the band that is most useful in highly-resolving body-wave tomography when using land stations. On the other hand, waveform inversion methods, unlike traditional ray theory, do not necessarily depend on the availability of clean, pulse-like broadband signals across the entire frequency range. For example in finite-frequency tomography, the method of our choice, modelling procedures permit the exclusion of unusable frequency bands on a case-by-case basis. Hence we investigate to what extent seismograms from the ocean-bottom and from island stations can be used for broadband waveform inversion of teleseismic P-waves, as compared to continental land stations. We have re-analyzed data from one of the largest onshore-offshore, broadband, long-term seismological experiment to date: the Hawaiian PLUME project (Wolfe et al. 2009, Laske 2009). The data quality was studied in eight overlapping frequency bands (dominant periods between 30.0 s and 2.7 s), for year-long records from 62 ocean-bottom stations (January 2005 - June 2007), complemented by seismograms from 74 regional island stations and 236 continental stations from four different networks on the Pacific-rim, recorded in the same time frame. P-wave seismograms from 103 earthquakes of moment magnitude 6.2 and above, recorded at epicentral distances of 32° to 85° to Hawaii were assessed in this study. The quality of the recorded data was evaluated by calculating the cross-correlation coefficient between the first 1.5 dominant periods of real and predicted waveforms, in eight frequency passbands and on the broadband waveform, after careful correction for source parameters and source time function (Sigloch and Nolet 2006). As expected, permanent continental stations were quieter than permanent island stations in the Pacific, (independent of frequency band), and island stations were quieter than ocean-bottom stations. Relative data quality for both types of oceanic stations is lowest for dominant periods between 11s and 3 s. We present statistics for the fraction of usable data, as a function of station type, frequency band, and sensor type. In the lowest frequency band 55%, 71% and 90% of the data recorded by the PLUME stations, island stations and land stations, respectively, can be used for seismic tomography. These values drop with increasing frequency, to a minimum of 12% for the island stations, 8% for OBS stations and 33% for the land stations. We also compare data quality by OBS sensor type (Nanometrics T-40, Nanometrics T-240, Güralp CMG-3T). We find that frequency bands around 2.7 s and between 20.0 to 30.0 s have low noise levels but have not been used for tomography by the project PIs. A multiple-frequency waveform inversion including these additional bands and wave paths, as well as a larger number of earthquakes (101 versus 97 and 59 used in the original studies by Wolfe et al. 2009 and Wolfe et al. 2011) should be able to improve the resolution of the velocity structure in the upper and lower mantle beneath the Hawaiian hotspot. References: Laske, G., Collins, J. A., Wolfe, C. J., Solomon, S. C., Detrick, R. S., Orcutt, J. A., Bercovici, D., Hauri, E. H. (2009). Probing the Hawaiian hotspot with new broadband ocean bottom instruments. Eos Trans. AGU, 90(41), 362-363. Sigloch, K., & Nolet, G. (2006). Measuring finite-frequency body-wave amplitudes and traveltimes. Geophysical Journal International, 167(1), 271-287, doi:10.1111/j.1365-246X.2006.03116.x Wolfe, C.J, Solomon, S.C., Laske G., Collins, J.A., Detrick, R.S., Orcutt, J.A., Bercovici, D., and Hauri, E.H. (2009) Mantle shear-wave velocity structure beneath the Hawaiian hot spot. Science (New York, N.Y.), 326(5958), 1388-1390. Wolfe, C.J, Solomon, S.C., Laske G., Collins, J.A., Detrick, R.S., Orcutt, J.A., Bercovici, D., and Hauri, E.H. (2011) Mantle P-wave velocity structure beneath the Hawaiian hotspot. Earth and Planetary Science Letters, 303(3-4), 267-280.

A CERES-like Cloud Property Climatology Using AVHRR Data

NASA Astrophysics Data System (ADS)

Minnis, P.; Bedka, K. M.; Yost, C. R.; Trepte, Q.; Bedka, S. T.; Sun-Mack, S.; Doelling, D.

2015-12-01

Clouds affect the climate system by modulating the radiation budget and distributing precipitation. Variations in cloud patterns and properties are expected to accompany changes in climate. The NASA Clouds and the Earth's Radiant Energy System (CERES) Project developed an end-to-end analysis system to measure broadband radiances from a radiometer and retrieve cloud properties from collocated high-resolution MODerate-resolution Imaging Spectroradiometer (MODIS) data to generate a long-term climate data record of clouds and clear-sky properties and top-of-atmosphere radiation budget. The first MODIS was not launched until 2000, so the current CERES record is only 15 years long at this point. The core of the algorithms used to retrieve the cloud properties from MODIS is based on the spectral complement of the Advanced Very High Resolution Radiometer (AVHRR), which has been aboard a string of satellites since 1978. The CERES cloud algorithms were adapted for application to AVHRR data and have been used to produce an ongoing CERES-like cloud property and surface temperature product that includes an initial narrowband-based radiation budget. This presentation will summarize this new product, which covers nearly 37 years, and its comparability with cloud parameters from CERES, CALIPSO, and other satellites. Examples of some applications of this dataset are given and the potential for generating a long-term radiation budget CDR is also discussed.

46 CFR 282.21 - Wages of officers and crew.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Definitions. When used in this part. (1) Base period. The first base period under the wage index system, as... employment of the approved manning complement of the subsidized vessel, including payments required by law to... assessments on crew payrolls. (4) Approved manning complement means the complement approved by the Board for...

Complement, a target for therapy in inflammatory and degenerative diseases.

PubMed

Morgan, B Paul; Harris, Claire L

2015-12-01

The complement system is a key innate immune defence against infection and an important driver of inflammation; however, these very properties can also cause harm. Inappropriate or uncontrolled activation of complement can cause local and/or systemic inflammation, tissue damage and disease. Complement provides numerous options for drug development as it is a proteolytic cascade that involves nine specific proteases, unique multimolecular activation and lytic complexes, an arsenal of natural inhibitors, and numerous receptors that bind to activation fragments. Drug design is facilitated by the increasingly detailed structural understanding of the molecules involved in the complement system. Only two anti-complement drugs are currently on the market, but many more are being developed for diseases that include infectious, inflammatory, degenerative, traumatic and neoplastic disorders. In this Review, we describe the history, current landscape and future directions for anti-complement therapies.

Mantle P wave travel time tomography of Eastern and Southern Africa: New images of mantle upwellings

NASA Astrophysics Data System (ADS)

Benoit, M. H.; Li, C.; van der Hilst, R.

2006-12-01

Much of Eastern Africa, including Ethiopia, Kenya, and Tanzania, has undergone extensive tectonism, including rifting, uplift, and volcanism during the Cenozoic. The cause of this tectonism is often attributed to the presence of one or more mantle upwellings, including starting thermal plumes and superplumes. Previous regional seismic studies and global tomographic models show conflicting results regarding the spatial and thermal characteristics of these upwellings. Additionally, there are questions concerning the extent to which the Archean and Proterozoic lithosphere has been altered by possible thermal upwellings in the mantle. To further constrain the mantle structure beneath Southern and Eastern Africa and to investigate the origin of the tectonism in Eastern Africa, we present preliminary results of a large-scale P wave travel time tomographic study of the region. We invert travel time measurements from the EHB database with travel time measurements taken from regional PASSCAL datasets including the Ethiopia Broadband Seismic Experiment (2000-2002); Kenya Broadband Seismic Experiment (2000-2002); Southern Africa Seismic Experiment (1997- 1999); Tanzania Broadband Seismic Experiment (1995-1997), and the Saudi Arabia PASSCAL Experiment (1995-1997). The tomographic inversion uses 3-D sensitivity kernels to combine different datasets and is parameterized with an irregular grid so that high spatial resolution can be obtained in areas of dense data coverage. It uses an adaptive least-squares context using the LSQR method with norm and gradient damping.

Multi-wavelength Observations of the Enduring Type IIn Supernovae 2005ip and 2006jd

NASA Astrophysics Data System (ADS)

Stritzinger, Maximilian; Taddia, Francesco; Fransson, Claes; Fox, Ori D.; Morrell, Nidia; Phillips, M. M.; Sollerman, Jesper; Anderson, J. P.; Boldt, Luis; Brown, Peter J.; Campillay, Abdo; Castellon, Sergio; Contreras, Carlos; Folatelli, Gastón; Habergham, S. M.; Hamuy, Mario; Hjorth, Jens; James, Phil A.; Krzeminski, Wojtek; Mattila, Seppo; Persson, Sven E.; Roth, Miguel

2012-09-01

We present an observational study of the Type IIn supernovae (SNe IIn) 2005ip and 2006jd. Broadband UV, optical, and near-IR photometry, and visual-wavelength spectroscopy of SN 2005ip complement and extend upon published observations to 6.5 years past discovery. Our observations of SN 2006jd extend from UV to mid-infrared wavelengths, and like SN 2005ip, are compared to reported X-ray measurements to understand the nature of the progenitor. Both objects display a number of similarities with the 1988Z-like subclass of SN IIn including (1) remarkably similar early- and late-phase optical spectra, (2) a variety of high-ionization coronal lines, (3) long-duration optical and near-IR emission, and (4) evidence of cold and warm dust components. However, diversity is apparent, including an unprecedented late-time r-band excess in SN 2006jd. The observed differences are attributed to differences between the mass-loss history of the progenitor stars. We conclude that the progenitor of SN 2006jd likely experienced a significant mass-loss event during its pre-SN evolution akin to the great 19th century eruption of η Carinae. Contrarily, as advocated by Smith et al., the circumstellar environment of SN 2005ip is found to be more consistent with a clumpy wind progenitor. This paper includes data gathered with the 6.5 m Magellan Telescopes, located at Las Campanas Observatory, Chile; the Gemini-North Telescope, Mauna Kea, USA (Gemini Program GN-2010B-Q-67, PI: Stritzinger); the ESO NTT, La Silla, Chile (Program 076.A-0156 and 078.D-0048, PI: Hamuy); and the INT and the NOT (Proposal number 45 - 004, PI: Taddia), La Palma, Spain.

Identification of C3b-binding Small Molecule Complement Inhibitors Using Cheminformatics

PubMed Central

Garcia, Brandon L.; Skaff, D. Andrew; Chatterjee, Arindam; Hanning, Anders; Walker, John K.; Wyckoff, Gerald J.; Geisbrecht, Brian V.

2017-01-01

The complement system is an elegantly regulated biochemical cascade formed by the collective molecular recognition properties and proteolytic activities of over two dozen membrane-bound or serum proteins. Complement plays diverse roles in human physiology which include acting as a sentry against invading microorganisms, priming of the adaptive immune response, and removal of immune complexes. However, dysregulation of complement can serve as a trigger for a wide range of human diseases which include autoimmune, inflammatory, and degenerative conditions. Despite several potential advantages of modulating complement with small molecule inhibitors, small molecule drugs are highly underrepresented in the current complement-directed therapeutics pipeline. In this study we have employed a cheminformatics drug discovery approach based on the extensive structural and functional knowledge available for the central proteolytic fragment of the cascade, C3b. Using parallel in silico screening methodologies we identified 45 small molecules which putatively bind C3b near ligand-guided functional hot-spots. Surface plasmon resonance experiments resulted in the validation of seven dose-dependent C3b-binding compounds. Competition-based biochemical assays demonstrated the ability of several C3b-binding compounds to interfere with binding of the original C3b ligand which guided their discovery. In vitro assays of complement function identified a single complement inhibitory compound, termed cmp-5, and mechanistic studies of the cmp-5 inhibitory mode revealed it acts at the level of C5 activation. This study has led to the identification of a promising new class of C3b-binding small molecule complement inhibitors, and to our knowledge, provides the first demonstration of cheminformatics-based complement-directed drug discovery. PMID:28298523

The relationship investigation between factors affecting demand for broadband and the level of satisfaction among broadband customers in the South East Coast of Sabah, Malaysia

NASA Astrophysics Data System (ADS)

Hashim, S. H. A.; Hamid, F. A.; Kiram, J. J.; Sulaiman, J.

2017-09-01

This paper aims to investigate the relationship between factors that affecting the demand for broadband and the level of satisfaction. Previous researchers have found that the adoption of broadband is greatly influenced by many factors. Thus, in this study, a self-administered questionnaire was developed to obtain the factors affecting demand for broadband among broadband customers as well as their level of satisfaction. Pearson correlation, one-way analysis of variance (ANOVA) and t-test were used for statistical interpretation of the relationship. This study shows that there are better relationships between several factors over demand for broadband and satisfaction level.

Demonstration of Multi-Gbps Data Rates at Ka-Band Using Software-Defined Modem and Broadband High Power Amplifier for Space Communications

NASA Technical Reports Server (NTRS)

Simons, Rainee N.; Wintucky, Edwin G.; Landon, David G.; Sun, Jun Y.; Winn, James S.; Laraway, Stephen; McIntire, William K.; Metz, John L.; Smith, Francis J.

2011-01-01

The paper presents the first ever research and experimental results regarding the combination of a software-defined multi-Gbps modem and a broadband high power space amplifier when tested with an extended form of the industry standard DVB-S2 and LDPC rate 9/10 FEC codec. The modem supports waveforms including QPSK, 8-PSK, 16-APSK, 32-APSK, 64-APSK, and 128-QAM. The broadband high power amplifier is a space qualified traveling-wave tube (TWT), which has a passband greater than 3 GHz at 33 GHz, output power of 200 W and efficiency greater than 60 percent. The modem and the TWTA together enabled an unprecedented data rate at 20 Gbps with low BER of 10(exp -9). The presented results include a plot of the received waveform constellation, BER vs. E(sub b)/N(sub 0) and implementation loss for each of the modulation types tested. The above results when included in an RF link budget analysis show that NASA s payload data rate can be increased by at least an order of magnitude (greater than 10X) over current state-of-practice, limited only by the spacecraft EIRP, ground receiver G/T, range, and available spectrum or bandwidth.

[Renal risks of dietary complements: a forgotten cause].

PubMed

Dori, Olympia; Humbert, Antoine; Burnier, Michel; Teta, Daniel

2014-02-26

The use of dietary complements like vitamins, minerals, trace elements, proteins, aminoacids and plant-derived agents is prevalent in the general population, in order to promote health and treat diseases. Dietary complements are considered as safe natural products and are easily available without prescription. However, these can lead to severe renal toxicity, especially in cases of unknown pre-existing chronic kidney disease (CKD). In particular, Chinese herbs including aristolochic acid, high doses of vitamine C, creatine and protein complements may lead to acute and chronic renal failure, sometimes irreversible. Dietary complement toxicity should be suspected in any case of unexplained renal impairement. In the case of pre-existing CKD, the use of potentially nephrotoxic dietary complements should be screened for.

Novel dynamic tuning of broadband visible metamaterial perfect absorber using graphene

NASA Astrophysics Data System (ADS)

Jia, Xiuli; Wang, Xiaoou; Yuan, Chengxun; Meng, Qingxin; Zhou, Zhongxiang

2016-07-01

We present a novel dynamic tuning of a broadband visible metamaterial absorber consisting of a multilayer-graphene-embedded nano-cross elliptical hole (MGENCEH) structure. It has multiple effects, including excitation of surface plasmon polaritons and extraordinary optical transmission in the first two metal layers. A numerical simulation shows that the MGENCEH structure can realize broadband perfect absorption (BPA) from 5.85 × 1014 to 6.5 × 1014 Hz over a wide incident angle range for transverse magnetic polarized light if the chemical potential of graphene (uc) is tuned to 1.0 eV. Furthermore, it has high broadband absorption (above 96%) from 4.6 × 1014 to 6.6 × 1014 Hz and three areas of narrowband perfect absorption around 4.65 × 1014, 5.1 × 1014, and 5.6 × 1014 Hz. The changes in the absorption spectra as a function of uc can be classically explained by simply considering plasmons as damped harmonic oscillators. This BPA is broader than the result of Zhou et al. [Opt. Express 23, A413-A418 (2015)] and is particularly desirable for various potential applications such as solar energy absorbers.

A PDA study management tool (SMT) utilizing wireless broadband and full DICOM viewing capability

NASA Astrophysics Data System (ADS)

Documet, Jorge; Liu, Brent; Zhou, Zheng; Huang, H. K.; Documet, Luis

2007-03-01

During the last 4 years IPI (Image Processing and Informatics) Laboratory has been developing a web-based Study Management Tool (SMT) application that allows Radiologists, Film librarians and PACS-related (Picture Archiving and Communication System) users to dynamically and remotely perform Query/Retrieve operations in a PACS network. The users utilizing a regular PDA (Personal Digital Assistant) can remotely query a PACS archive to distribute any study to an existing DICOM (Digital Imaging and Communications in Medicine) node. This application which has proven to be convenient to manage the Study Workflow [1, 2] has been extended to include a DICOM viewing capability in the PDA. With this new feature, users can take a quick view of DICOM images providing them mobility and convenience at the same time. In addition, we are extending this application to Metropolitan-Area Wireless Broadband Networks. This feature requires Smart Phones that are capable of working as a PDA and have access to Broadband Wireless Services. With the extended application to wireless broadband technology and the preview of DICOM images, the Study Management Tool becomes an even more powerful tool for clinical workflow management.

Estimation of chromatic errors from broadband images for high contrast imaging

NASA Astrophysics Data System (ADS)

Sirbu, Dan; Belikov, Ruslan

2015-09-01

Usage of an internal coronagraph with an adaptive optical system for wavefront correction for direct imaging of exoplanets is currently being considered for many mission concepts, including as an instrument addition to the WFIRST-AFTA mission to follow the James Web Space Telescope. The main technical challenge associated with direct imaging of exoplanets with an internal coronagraph is to effectively control both the diffraction and scattered light from the star so that the dim planetary companion can be seen. For the deformable mirror (DM) to recover a dark hole region with sufficiently high contrast in the image plane, wavefront errors are usually estimated using probes on the DM. To date, most broadband lab demonstrations use narrowband filters to estimate the chromaticity of the wavefront error, but this reduces the photon flux per filter and requires a filter system. Here, we propose a method to estimate the chromaticity of wavefront errors using only a broadband image. This is achieved by using special DM probes that have sufficient chromatic diversity. As a case example, we simulate the retrieval of the spectrum of the central wavelength from broadband images for a simple shaped- pupil coronagraph with a conjugate DM and compute the resulting estimation error.

Amplitude modulation detection by human listeners in reverberant sound fields: Carrier bandwidth effects and binaural versus monaural comparison.

PubMed

Zahorik, Pavel; Kim, Duck O; Kuwada, Shigeyuki; Anderson, Paul W; Brandewie, Eugene; Collecchia, Regina; Srinivasan, Nirmal

2012-06-01

Previous work [Zahorik et al., POMA, 12, 050005 (2011)] has reported that for a broadband noise carrier signal in a simulated reverberant sound field, human sensitivity to amplitude modulation (AM) is higher than would be predicted based on the broadband acoustical modulation transfer function (MTF) of the listening environment. Interpretation of this result was complicated by the fact that acoustical MTFs of rooms are often quite different for different carrier frequency regions, and listeners may have selectively responded to advantageous carrier frequency regions where the effective acoustic modulation loss due to the room was less than indicated by a broadband acoustic MTF analysis. Here, AM sensitivity testing and acoustic MTF analyses were expanded to include narrowband noise carriers (1-octave and 1/3-octave bands centered at 4 kHz), as well as monaural and binaural listening conditions. Narrowband results were found to be consistent with broadband results: In a reverberant sound field, human AM sensitivity is higher than indicated by the acoustical MTFs. The effect was greatest for modulation frequencies above 32 Hz and was present whether the stimulation was monaural or binaural. These results are suggestive of mechanisms that functionally enhance modulation in reverberant listening.

Determination of a Unique Epitope Binding Site for a Complement-Lysis- Enhancing Monoclonal Antibody, 3D12, on the Galactose Adherence Lectin of Entamoeba histolytica, Using BIAcore.

DTIC Science & Technology

1992-05-01

COMPLEMENT-LYSIS-ENHANCING MONOCLONAL ANTIBODY, 3D12, ON THE GALACTOSE ADHERENCE LECTIN OF ENTAMOEBA HISTOLYTICA, USING BIAcore Sheila J. Wood...Binding 5. FUNDING NUMBERS Site for a Complement-Lysis-Enhancing Monoclonal Antibody, 3D12, on the Galactose Adherence Lectin of Entamoeba Hiiutolitica...Mechani sms of pathogenicity used by Entamoeba histolytica to invade the bloodstream and cause liver abscess, include complement mediated lysis

75 FR 27984 - Broadband Technology Opportunities Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-19

....: 0907141137-0222-10] RIN 0660-ZA28 Broadband Technology Opportunities Program AGENCY: National...; Reopening of Application Filing Window for Broadband Technology Opportunities Program Comprehensive... filing window for the Broadband Technology Opportunities Program (BTOP) that the agency established...

75 FR 3791 - Broadband Technology Opportunities Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-22

... Department of Agriculture Rural Utilities Service Broadband Technology Opportunities Program; Notices #0;#0... 0660-ZA28 Broadband Technology Opportunities Program AGENCY: National Telecommunications and... for the Broadband Technology Opportunities Program (BTOP or Program) that the agency established...

Handheld emissions detector (HED): overview and development

NASA Astrophysics Data System (ADS)

Valentino, George J.; Schimmel, David

2009-05-01

Nova Engineering, Cincinnati OH, a division of L-3 Communications (L-3 Nova), under the sponsorship of Program Manager Soldier Warrior (PM-SWAR), Fort Belvoir, VA, has developed a Soldier portable, light-weight, hand-held, geolocation sensor and processing system called the Handheld Emissions Detector (HED). The HED is a broadband custom receiver and processor that allows the user to easily sense, direction find, and locate a broad range of emitters in the user's surrounding area. Now in its second design iteration, the HED incorporates a set of COTS components that are complemented with L-3 Nova custom RF, power, digital, and mechanical components, plus custom embedded and application software. The HED user interfaces are designed to provide complex information in a readily-understandable form, thereby providing actionable results for operators. This paper provides, where possible, the top-level characteristics of the HED as well as the rationale behind its design philosophy along with its applications in both DOD and Commercial markets.

Simulation of Cascaded Longitudinal-Space-Charge Amplifier at the Fermilab Accelerator Science & Technology (Fast) Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halavanau, A.; Piot, P.

2015-12-01

Cascaded Longitudinal Space Charge Amplifiers (LSCA) have been proposed as a mechanism to generate density modulation over a board spectral range. The scheme has been recently demonstrated in the optical regime and has confirmed the production of broadband optical radiation. In this paper we investigate, via numerical simulations, the performance of a cascaded LSCA beamline at the Fermilab Accelerator Science & Technology (FAST) facility to produce broadband ultraviolet radiation. Our studies are carried out using elegant with included tree-based grid-less space charge algorithm.

Reflection spectra of etched FBGs under the influence of axial contraction and stress-induced index change.

PubMed

Yang, Hang-Zhou; Lim, Kok-Sing; Qiao, Xue-Guang; Chong, Wu-Yi; Cheong, Yew-Ken; Lim, Weng-Hong; Lim, Wei-Sin; Ahmad, Harith

2013-06-17

We present a new theoretical model for the broadband reflection spectra of etched FBGs which includes the effects of axial contraction and stress-induced index change. The reflection spectra of the etched FBGs with several different taper profiles are simulated based on the proposed model. In our observation, decaying exponential profile produces a broadband reflection spectrum with good uniformity over the range of 1540-1560 nm. An etched FBG with similar taper profile is fabricated and the experimental result shows good agreement with the theoretical model.

The Complement System and Adverse Pregnancy Outcomes

PubMed Central

Regal, Jean F.; Gilbert, Jeffrey S.; Burwick, Richard M.

2015-01-01

Adverse pregnancy outcomes significantly contribute to morbidity and mortality for mother and child, with lifelong health consequences for both. The innate and adaptive immune system must be regulated to insure survival of the feta allograft, and the complement system is no exception. An intact complement system optimizes placental development and function and is essential to maintain host defense and fetal survival. Complement regulation is apparent at the placental interface from early pregnancy with some degree of complement activation occurring normally throughout gestation. However, a number of pregnancy complications including early pregnancy loss, fetal growth restriction, hypertensive disorders of pregnancy and preterm birth are associated with excessive or misdirected complement activation, and are more frequent in women with inherited or acquired complement system disorders or complement gene mutations. Clinical studies employing complement biomarkers in plasma and urine implicate dysregulated complement activation in components of each of the adverse pregnancy outcomes. In addition, mechanistic studies in rat and mouse models of adverse pregnancy outcomes address the complement pathways or activation products of importance and allow critical analysis of the pathophysiology. Targeted complement therapeutics are already in use to control adverse pregnancy outcomes in select situations. A clearer understanding of the role of the complement system in both normal pregnancy and complicated or failed pregnancy will allow a rational approach to future therapeutic strategies for manipulating complement with the goal of mitigating adverse pregnancy outcomes, preserving host defense, and improving long term outcomes for both mother and child. PMID:25802092

Syntactic and Semantic Coordination in Finite Complement-Clause Constructions: A Diary-Based Case Study

ERIC Educational Resources Information Center

Köymen, Bahar; Lieven, Elena; Brandt, Silke

2016-01-01

This study investigates the coordination of matrix and subordinate clauses within finite complement-clause constructions. The data come from diary and audio recordings which include the utterances produced by an American English-speaking child, L, between the ages 1;08 and 3;05. We extracted all the finite complement-clause constructions that L…

On-board B-ISDN fast packet switching architectures. Phase 1: Study

NASA Technical Reports Server (NTRS)

Faris, Faris; Inukai, Thomas; Lee, Fred; Paul, Dilip; Shyy, Dong-Jye

1993-01-01

The broadband integrate services digital network (B-ISDN) is an emerging telecommunications technology that will meet most of the telecommunications networking needs in the mid-1990's to early next century. The satellite-based system is well positioned for providing B-ISDN service with its inherent capabilities of point-to-multipoint and broadcast transmission, virtually unlimited connectivity between any two points within a beam coverage, short deployment time of communications facility, flexible and dynamic reallocation of space segment capacity, and distance insensitive cost. On-board processing satellites, particularly in a multiple spot beam environment, will provide enhanced connectivity, better performance, optimized access and transmission link design, and lower user service cost. The following are described: the user and network aspects of broadband services; the current development status in broadband services; various satellite network architectures including system design issues; and various fast packet switch architectures and their detail designs.

Unbundling in Current Broadband and Next-Generation Ultra-Broadband Access Networks

NASA Astrophysics Data System (ADS)

Gaudino, Roberto; Giuliano, Romeo; Mazzenga, Franco; Valcarenghi, Luca; Vatalaro, Francesco

2014-05-01

This article overviews the methods that are currently under investigation for implementing multi-operator open-access/shared-access techniques in next-generation access ultra-broadband architectures, starting from the traditional "unbundling-of-the-local-loop" techniques implemented in legacy twisted-pair digital subscriber line access networks. A straightforward replication of these copper-based unbundling-of-the-local-loop techniques is usually not feasible on next-generation access networks, including fiber-to-the-home point-to-multipoint passive optical networks. To investigate this issue, the article first gives a concise description of traditional copper-based unbundling-of-the-local-loop solutions, then focalizes on both next-generation access hybrid fiber-copper digital subscriber line fiber-to-the-cabinet scenarios and on fiber to the home by accounting for the mix of regulatory and technological reasons driving the next-generation access migration path, focusing mostly on the European situation.

Ultra-wideband microwave absorber by connecting multiple absorption bands of two different-sized hyperbolic metamaterial waveguide arrays.

PubMed

Yin, Xiang; Long, Chang; Li, Junhao; Zhu, Hua; Chen, Lin; Guan, Jianguo; Li, Xun

2015-10-19

Microwave absorbers have important applications in various areas including stealth, camouflage, and antenna. Here, we have designed an ultra-broadband light absorber by integrating two different-sized tapered hyperbolic metamaterial (HMM) waveguides, each of which has wide but different absorption bands due to broadband slow-light response, into a unit cell. Both the numerical and experimental results demonstrate that in such a design strategy, the low absorption bands between high absorption bands with a single-sized tapered HMM waveguide array can be effectively eliminated, resulting in a largely expanded absorption bandwidth ranging from 2.3 to 40 GHz. The presented ultra-broadband light absorber is also insensitive to polarization and robust against incident angle. Our results offer a further step in developing practical artificial electromagnetic absorbers, which will impact a broad range of applications at microwave frequencies.

Toward multidomain integrated network management for ATM and SDH networks

NASA Astrophysics Data System (ADS)

Galis, Alex; Gantenbein, Dieter; Covaci, Stefan; Bianza, Carlo; Karayannis, Fotis; Mykoniatis, George

1996-12-01

ACTS Project AC080 MISA has embarked upon the task of realizing and validating via European field trials integrated end-to-end management of hybrid SDH and ATM networks in the framework of open network provision. This paper reflects the initial work of the project and gives an overview of the proposed MISA system architecture and initial design. We describe our understanding of the underlying enterprise model in the network management context, including the concept of the MISA Global Broadband Connectivity Management service. It supports Integrated Broadband Communication by defining an end-to-end broadband connection service in a multi-domain business environment. Its implementation by the MISA consortium within trials across Europe aims for an efficient management of network resources of the SDH and ATM infrastructure, considering optimum end-to-end quality of service and the needs of a number of telecommunication actors: customers, value-added service providers, and network providers.

Demonstrating Broadband Billion-to-One Contrast with the Visible Nulling Coronagraph

NASA Technical Reports Server (NTRS)

Hicks, Brian A.; Lyon, Richard G.; Petrone, Peter, III; Miller, Ian J.; Bolcar, Matthew R.; Clampin, Mark; Helmbrecht, Michael A.; Mallik, Udayan

2015-01-01

The key to broadband operation of the Visible Nulling Coronagraph (VNC) is achieving a condition of quasi- achromatic destructive interference between combined beams. Here we present efforts towards meeting this goal using Fresnel rhombs in each interferometric arm as orthogonally aligned half wave phase retarders. The milestone goal of the demonstration is to achieve 1 × 10-9 contrast at 2/D over a 40 nm bandpass centered at 633 nm. Rhombs have been designed and fabricated, and a multi-step approach to alignment using coarse positioners for each rhomb and pair has been developed to get within range of piezo stages used for fine positioning. The previously demonstrated narrowband VNC sensing and control approach that uses a segmented deformable mirror is being adapted to broadband to include fine positioning of the piezo-mounted rhombs, all demonstrated in a low-pressure environment.

Soft and broadband infrared metamaterial absorber based on gold nanorod/liquid crystal hybrid with tunable total absorption

PubMed Central

Su, Zhaoxian; Yin, Jianbo; Zhao, Xiaopeng

2015-01-01

We design a soft infrared metamaterial absorber based on gold nanorods dispersed in liquid crystal (LC) placed on a gold film and theoretically investigate its total absorption character. Because the nanorods align with the LC molecule, the gold nanorods/LC hybrid exhibits different permittivity as a function of tilt angle of LC. At a certain tilt angle, the absorber shows an omnidirectional total absorption effect. By changing the tilt angle of LC by an external electric field, the total absorption character can be adjusted. The total absorption character also depends on the concentration, geometric dimension of nanorods, and defect of nanorod arrangement in LC. When the LC contains different size of gold nanorods, a broadband absorption can be easily realized. The characteristics including flexibility, omnidirectional, broadband and tunablility make the infrared metamaterial absorber possess potential use in smart metamaterial devices. PMID:26576660

Introduction to the High-Rate GPS Network of Puerto Rico and the U.S. Virgin Islands

NASA Astrophysics Data System (ADS)

Wang, G.; Hillebrandt, C. V.; Martinez, J. M.; Huerfano, V.; Schellekens, J.

2008-12-01

The Puerto Rico Seismic Network at the University of Puerto Rico at Mayagüez is a regional earthquake and tsunami monitoring institute. One of its primary objective is to provide timely and reliable earthquake and tsunami information and warning to the state (Puerto Rico) and local governments, the US and British Virgin Islands, as well as to the general public. In the past five years, it has been expanding its operations for the establishment of a Caribbean Tsunami Warning Center. With funding of the Puerto Rico government and NOAA, it is operated 24 hours per day and 7 days per week. Broadband seismometers are generally unable to capture the full bandwidth of long period ground motions following very large earthquakes. As a result, it is difficult to rapidly estimate the true magnitudes of large earthquakes using only seismic data. High-rate GPS has been justified as a very useful tool in recording long-period and permanent earthquake ground motions. Estimation of the true magnitude (and therefore tsunami potential) of large earthquakes may be determined more accurately in a timely manner (minutes after the quake) using high rate GPS observations. With the major aim of improving the ability of the PRSN in rapidly and precisely monitoring large earthquakes, NSF funded a Major Research Instrumentation (MRI) project, Acquisition of 9 High-rate GPS Units for Developing a Broadband Earthquake Observation System in Puerto Rico and the U.S. Virgin Islands (EAR-0722540, August 1, 2007-July 31, 2009). The major purpose of this project is to build a high-rate GPS network in Puerto Rico and the U.S. Virgin Islands. The GPS network includes 3 campaign and 6 permanent GPS stations. These campaign stations were designed to use in emergency response after large earthquakes to get co-seismic and post-seismic displacement. These six permanent stations were designed to complement current seismic observation system of Puerto Rico and U.S. Virgin Islands. We have installed three permanent GPS stations in May, 2008. They locate in Arecibo Observatory, Bayamon Science Park, and Caja de Muertos Island. We will install the other three stations in October, 2008. They will be located in Mona, Culebra, and St. Thomas islands. All of these permanent GPS stations are colocated with seismic stations operated by the Puerto Rico Seismic Network and the Puerto Rico Strong Motion Program. They are also very-closely spaced to the Tide Gauge stations operated by PRSN and NOAA. Therefore they will also complement the tide gauge sea-level observation system to get accurate absolute sea-level changes after large earthquakes. The integrated velocitymeter-accelerometer- GPS earthquake observation system will advance knowledge of seismic wave propagation, the kinematics and dynamics of fault rupture process, pre-seismic, co-seismic and post-seismic deformation, and is also likely to be useful for improving building and critical structure designs. It will support earthquake and tsunami hazards research and mitigation in Puerto Rico and the surrounding region. High-rate GPS observations can also be used for real time tropospheric water vapor tomography which is useful for weather prediction, including improved hurricane track forecasting. Raw GPS data are freely available through the UNAVCO archive. As a result, a large number of researchers can potentially benefit from the data for research and applications ranging from neotectonics to atmospheric science to civil engineering.

Non-specific adsorption of complement proteins affects complement activation pathways of gold nanomaterials.

PubMed

Quach, Quang Huy; Kah, James Chen Yong

2017-04-01

The complement system is a key humoral component of innate immunity, serving as the first line of defense against intruders, including foreign synthetic nanomaterials. Although gold nanomaterials (AuNMs) are widely used in nanomedicine, their immunological response is not well understood. Using AuNMs of three shapes commonly used in biomedical applications: spherical gold nanoparticles, gold nanostars and gold nanorods, we demonstrated that AuNMs activated whole complement system, leading to the formation of SC5b-9 complex. All three complement pathways were simultaneously activated by all the AuNMs. Recognition molecules of the complement system interacted with all AuNMs in vitro, except for l-ficolin, but the correlation between these interactions and corresponding complement pathway activation was only observed in the classical and alternative pathways. We also observed the mediating role of complement activation in cellular uptake of all AuNMs by human U937 promonocytic cells, which expresses complement receptors. Taken together, our results highlighted the potential immunological challenges for clinical applications of AuNMs that were often overlooked.

Complement-Mediated Regulation of Metabolism and Basic Cellular Processes.

PubMed

Hess, Christoph; Kemper, Claudia

2016-08-16

Complement is well appreciated as a critical arm of innate immunity. It is required for the removal of invading pathogens and works by directly destroying them through the activation of innate and adaptive immune cells. However, complement activation and function is not confined to the extracellular space but also occurs within cells. Recent work indicates that complement activation regulates key metabolic pathways and thus can impact fundamental cellular processes, such as survival, proliferation, and autophagy. Newly identified functions of complement include a key role in shaping metabolic reprogramming, which underlies T cell effector differentiation, and a role as a nexus for interactions with other effector systems, in particular the inflammasome and Notch transcription-factor networks. This review focuses on the contributions of complement to basic processes of the cell, in particular the integration of complement with cellular metabolism and the potential implications in infection and other disease settings. Copyright © 2016 Elsevier Inc. All rights reserved.

75 FR 3820 - Broadband Initiatives Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-22

... DEPARTMENT OF AGRICULTURE Rural Utilities Service RIN 0572-ZA01 Broadband Initiatives Program... policy and application procedures for the second round of funding under the broadband initiatives (the... Act) for the Broadband Initiatives Program (BIP) which provides loans, grants, and loan/grant...

Using animal models to determine the significance of complement activation in Alzheimer's disease

PubMed Central

Loeffler, David A

2004-01-01

Complement inflammation is a major inflammatory mechanism whose function is to promote the removal of microorganisms and the processing of immune complexes. Numerous studies have provided evidence for an increase in this process in areas of pathology in the Alzheimer's disease (AD) brain. Because complement activation proteins have been demonstrated in vitro to exert both neuroprotective and neurotoxic effects, the significance of this process in the development and progression of AD is unclear. Studies in animal models of AD, in which brain complement activation can be experimentally altered, should be of value for clarifying this issue. However, surprisingly little is known about complement activation in the transgenic animal models that are popular for studying this disorder. An optimal animal model for studying the significance of complement activation on Alzheimer's – related neuropathology should have complete complement activation associated with senile plaques, neurofibrillary tangles (if present), and dystrophic neurites. Other desirable features include both classical and alternative pathway activation, increased neuronal synthesis of native complement proteins, and evidence for an increase in complement activation prior to the development of extensive pathology. In order to determine the suitability of different animal models for studying the role of complement activation in AD, the extent of complement activation and its association with neuropathology in these models must be understood. PMID:15479474

Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion.

PubMed

Hovingh, Elise S; van den Broek, Bryan; Jongerius, Ilse

2016-01-01

The human complement system plays an important role in the defense against invading pathogens, inflammation and homeostasis. Invading microbes, such as bacteria, directly activate the complement system resulting in the formation of chemoattractants and in effective labeling of the bacteria for phagocytosis. In addition, formation of the membrane attack complex is responsible for direct killing of Gram-negative bacteria. In turn, bacteria have evolved several ways to evade complement activation on their surface in order to be able to colonize and invade the human host. One important mechanism of bacterial escape is attraction of complement regulatory proteins to the microbial surface. These molecules are present in the human body for tight regulation of the complement system to prevent damage to host self-surfaces. Therefore, recruitment of complement regulatory proteins to the bacterial surface results in decreased complement activation on the microbial surface which favors bacterial survival. This review will discuss recent advances in understanding the binding of complement regulatory proteins to the bacterial surface at the molecular level. This includes, new insights that have become available concerning specific conserved motives on complement regulatory proteins that are favorable for microbial binding. Finally, complement evasion molecules are of high importance for vaccine development due to their dominant role in bacterial survival, high immunogenicity and homology as well as their presence on the bacterial surface. Here, the use of complement evasion molecules for vaccine development will be discussed.

Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion

PubMed Central

Hovingh, Elise S.; van den Broek, Bryan; Jongerius, Ilse

2016-01-01

The human complement system plays an important role in the defense against invading pathogens, inflammation and homeostasis. Invading microbes, such as bacteria, directly activate the complement system resulting in the formation of chemoattractants and in effective labeling of the bacteria for phagocytosis. In addition, formation of the membrane attack complex is responsible for direct killing of Gram-negative bacteria. In turn, bacteria have evolved several ways to evade complement activation on their surface in order to be able to colonize and invade the human host. One important mechanism of bacterial escape is attraction of complement regulatory proteins to the microbial surface. These molecules are present in the human body for tight regulation of the complement system to prevent damage to host self-surfaces. Therefore, recruitment of complement regulatory proteins to the bacterial surface results in decreased complement activation on the microbial surface which favors bacterial survival. This review will discuss recent advances in understanding the binding of complement regulatory proteins to the bacterial surface at the molecular level. This includes, new insights that have become available concerning specific conserved motives on complement regulatory proteins that are favorable for microbial binding. Finally, complement evasion molecules are of high importance for vaccine development due to their dominant role in bacterial survival, high immunogenicity and homology as well as their presence on the bacterial surface. Here, the use of complement evasion molecules for vaccine development will be discussed. PMID:28066340

Measurement and prediction of broadband noise from large horizontal axis wind turbine generators

NASA Technical Reports Server (NTRS)

Grosveld, F. W.; Shepherd, K. P.; Hubbard, H. H.

1995-01-01

A method is presented for predicting the broadband noise spectra of large wind turbine generators. It includes contributions from such noise sources as the inflow turbulence to the rotor, the interactions between the turbulent boundary layers on the blade surfaces with their trailing edges and the wake due to a blunt trailing edge. The method is partly empirical and is based on acoustic measurements of large wind turbines and airfoil models. Spectra are predicted for several large machines including the proposed MOD-5B. Measured data are presented for the MOD-2, the WTS-4, the MOD-OA, and the U.S. Windpower Inc. machines. Good agreement is shown between the predicted and measured far field noise spectra.

Complement in the Initiation and Evolution of Rheumatoid Arthritis

PubMed Central

Holers, V. Michael; Banda, Nirmal K.

2018-01-01

The complement system is a major component of the immune system and plays a central role in many protective immune processes, including circulating immune complex processing and clearance, recognition of foreign antigens, modulation of humoral and cellular immunity, removal of apoptotic and dead cells, and engagement of injury resolving and tissue regeneration processes. In stark contrast to these beneficial roles, however, inadequately controlled complement activation underlies the pathogenesis of human inflammatory and autoimmune diseases, including rheumatoid arthritis (RA) where the cartilage, bone, and synovium are targeted. Recent studies of this disease have demonstrated that the autoimmune response evolves over time in an asymptomatic preclinical phase that is associated with mucosal inflammation. Notably, experimental models of this disease have demonstrated that each of the three major complement activation pathways plays an important role in recognition of injured joint tissue, although the lectin and amplification pathways exhibit particularly impactful roles in the initiation and amplification of damage. Herein, we review the complement system and focus on its multi-factorial role in human patients with RA and experimental murine models. This understanding will be important to the successful integration of the emerging complement therapeutics pipeline into clinical care for patients with RA. PMID:29892280

New seismic instrumentation packaged for all terrestrial environments (including the quietest observatories!).

NASA Astrophysics Data System (ADS)

Parker, Tim; Devanney, Peter; Bainbridge, Geoff; Townsend, Bruce

2017-04-01

The march to make every type of seismometer, weak to strong motion, reliable and economically deployable in any terrestrial environment continues with the availability of three new sensors and seismic systems including ones with over 200dB of dynamic range. Until recently there were probably 100 pier type broadband sensors for every observatory type pier, not the types of deployments geoscientists are needing to advance science and monitoring capability. Deeper boreholes are now the recognized quieter environments for best observatory class instruments and these same instruments can now be deployed in direct burial environments which is unprecedented. The experiences of facilities in large deployments of broadband seismometers in continental scale rolling arrays proves the utility of packaging new sensors in corrosion resistant casings and designing in the robustness needed to work reliably in temporary deployments. Integrating digitizers and other sensors decreases deployment complexity, decreases acquisition and deployment costs, increases reliability and utility. We'll discuss the informed evolution of broadband pier instruments into the modern integrated field tools that enable economic densification of monitoring arrays along with supporting new ways to approach geoscience research in a field environment.

78 FR 45464 - Broadband Data Improvement Act; Eligible Entities Aggregate Form 477 Data

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... or mobile broadband service provider advertises broadband transmission speeds of at least three.... DATES: Effective August 28, 2013. FOR FURTHER INFORMATION CONTACT: Suzanne Yelen, Assistant Division... availability. Providers of terrestrial mobile wireless (TMW) broadband services must continue to submit their...

Networked Nation: Broadband in America, 2007

ERIC Educational Resources Information Center

National Telecommunications and Information Administration, 2008

2008-01-01

This report highlights the dramatic growth of broadband in the United States. The report shows that the Administration's technology, regulatory and fiscal policies have stimulated innovation and competition, and encouraged investment in the U.S. broadband market contributing to significantly increased accessibility of broadband services. The…

Rotational Variability of Earth's Polar Regions: Implications for Detecting Snowball Planets

NASA Astrophysics Data System (ADS)

Cowan, Nicolas B.; Robinson, Tyler; Livengood, Timothy A.; Deming, Drake; Agol, Eric; A'Hearn, Michael F.; Charbonneau, David; Lisse, Carey M.; Meadows, Victoria S.; Seager, Sara; Shields, Aomawa L.; Wellnitz, Dennis D.

2011-04-01

We have obtained the first time-resolved, disk-integrated observations of Earth's poles with the Deep Impact spacecraft as part of the EPOXI mission of opportunity. These data mimic what we will see when we point next-generation space telescopes at nearby exoplanets. We use principal component analysis (PCA) and rotational light curve inversion to characterize color inhomogeneities and map their spatial distribution from these unusual vantage points, as a complement to the equatorial views presented by Cowan et al. in 2009. We also perform the same PCA on a suite of simulated rotational multi-band light curves from NASA's Virtual Planetary Laboratory three-dimensional spectral Earth model. This numerical experiment allows us to understand what sorts of surface features PCA can robustly identify. We find that the EPOXI polar observations have similar broadband colors as the equatorial Earth, but with 20%-30% greater apparent albedo. This is because the polar observations are most sensitive to mid-latitudes, which tend to be more cloudy than the equatorial latitudes emphasized by the original EPOXI Earth observations. The cloudiness of the mid-latitudes also manifests itself in the form of increased variability at short wavelengths in the polar observations and as a dominant gray eigencolor in the south polar observation. We construct a simple reflectance model for a snowball Earth. By construction, our model has a higher Bond albedo than the modern Earth; its surface albedo is so high that Rayleigh scattering does not noticeably affect its spectrum. The rotational color variations occur at short wavelengths due to the large contrast between glacier ice and bare land in those wavebands. Thus, we find that both the broadband colors and diurnal color variations of such a planet would be easily distinguishable from the modern-day Earth, regardless of viewing angle.

Genetic control of the alternative pathway of complement in humans and age-related macular degeneration

PubMed Central

Hecker, Laura A.; Edwards, Albert O.; Ryu, Euijung; Tosakulwong, Nirubol; Baratz, Keith H.; Brown, William L.; Issa, Peter Charbel; Scholl, Hendrik P.; Pollok-Kopp, Beatrix; Schmid-Kubista, Katharina E.; Bailey, Kent R.; Oppermann, Martin

2010-01-01

Activation of the alternative pathway of complement is implicated in common neurodegenerative diseases including age-related macular degeneration (AMD). We explored the impact of common variation in genes encoding proteins of the alternative pathway on complement activation in human blood and in AMD. Genetic variation across the genes encoding complement factor H (CFH), factor B (CFB) and component 3 (C3) was determined. The influence of common haplotypes defining transcriptional and translational units on complement activation in blood was determined in a quantitative genomic association study. Individual haplotypes in CFH and CFB were associated with distinct and novel effects on plasma levels of precursors, regulators and activation products of the alternative pathway of complement in human blood. Further, genetic variation in CFH thought to influence cell surface regulation of complement did not alter plasma complement levels in human blood. Plasma markers of chronic activation (split-products Ba and C3d) and an activating enzyme (factor D) were elevated in AMD subjects. Most of the elevation in AMD was accounted for by the genetic variation controlling complement activation in human blood. Activation of the alternative pathway of complement in blood is under genetic control and increases with age. The genetic variation associated with increased activation of complement in human blood also increased the risk of AMD. Our data are consistent with a disease model in which genetic variation in the complement system increases the risk of AMD by a combination of systemic complement activation and abnormal regulation of complement activation in local tissues. PMID:19825847

Safety of High Speed Guided Ground Transportation Systems. Broadband Magnetic Fields : Their Possible Role in EMF Associated Bioeffects

DOT National Transportation Integrated Search

1993-08-01

This report reviews electric and magnetic field (EMF) exposures from electrical transportation systems, including : electrically powered rail and magnetic levitation (maglev). Material also covered includes research concerning : biological effects of...

75 FR 35989 - Facilitating the Provision of Fixed and Mobile Broadband Access, Educational and Other Advanced...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-24

...] Facilitating the Provision of Fixed and Mobile Broadband Access, Educational and Other Advanced Services in the...), clarifying the requirements necessary for Broadband Radio Service (BRS) and Educational Broadband Service (EBS) licensees to demonstrate substantial service and ensure that BRS licensees of new initial...

47 CFR 27.1250 - Transition of the 2150-2160/62 MHz band from the Broadband Radio Service to the Advanced Wireless...

Code of Federal Regulations, 2013 CFR

2013-10-01

... the Broadband Radio Service to the Advanced Wireless Service. 27.1250 Section 27.1250 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service Relocation Procedures for the...

47 CFR 27.1250 - Transition of the 2150-2160/62 MHz band from the Broadband Radio Service to the Advanced Wireless...

Code of Federal Regulations, 2012 CFR

2012-10-01

... the Broadband Radio Service to the Advanced Wireless Service. 27.1250 Section 27.1250 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service Relocation Procedures for the...

47 CFR 27.1250 - Transition of the 2150-2160/62 MHz band from the Broadband Radio Service to the Advanced Wireless...

Code of Federal Regulations, 2014 CFR

2014-10-01

... the Broadband Radio Service to the Advanced Wireless Service. 27.1250 Section 27.1250 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service Relocation Procedures for the...

The renaissance of complement therapeutics

PubMed Central

Ricklin, Daniel; Mastellos, Dimitrios C.; Reis, Edimara S.; Lambris, John D.

2018-01-01

The increasing number of clinical conditions that involve a pathological contribution from the complement system — many of which affect the kidneys — has spurred a regained interest in therapeutic options to modulate this host defence pathway. Molecular insight, technological advances, and the first decade of clinical experience with the complement-specific drug eculizumab, have contributed to a growing confidence in therapeutic complement inhibition. More than 20 candidate drugs that target various stages of the complement cascade are currently being evaluated in clinical trials, and additional agents are in preclinical development. Such diversity is clearly needed in view of the complex and distinct involvement of complement in a wide range of clinical conditions, including rare kidney disorders, transplant rejection and haemodialysis-induced inflammation. The existing drugs cannot be applied to all complement-driven diseases, and each indication has to be assessed individually. Alongside considerations concerning optimal points of intervention and economic factors, patient stratification will become essential to identify the best complement-specific therapy for each individual patient. This Review provides an overview of the therapeutic concepts, targets and candidate drugs, summarizes insights from clinical trials, and reflects on existing challenges for the development of complement therapeutics for kidney diseases and beyond. PMID:29199277

Complement in Non-Antibody-Mediated Kidney Diseases

PubMed Central

Angeletti, Andrea; Reyes-Bahamonde, Joselyn; Cravedi, Paolo; Campbell, Kirk N.

2017-01-01

The complement system is part of the innate immune response that plays important roles in protecting the host from foreign pathogens. The complement components and relative fragment deposition have long been recognized to be strongly involved also in the pathogenesis of autoantibody-related kidney glomerulopathies, leading to direct glomerular injury and recruitment of infiltrating inflammation pathways. More recently, unregulated complement activation has been shown to be associated with progression of non-antibody-mediated kidney diseases, including focal segmental glomerulosclerosis, C3 glomerular disease, thrombotic microangiopathies, or general fibrosis generation in progressive chronic kidney diseases. Some of the specific mechanisms associated with complement activation in these diseases were recently clarified, showing a dominant role of alternative activation pathway. Over the last decade, a growing number of anticomplement agents have been developed, and some of them are being approved for clinical use or already in use. Therefore, anticomplement therapies represent a realistic choice of therapeutic approaches for complement-related diseases. Herein, we review the complement system activation, regulatory mechanisms, their involvement in non-antibody-mediated glomerular diseases, and the recent advances in complement-targeting agents as potential therapeutic strategies. PMID:28748184

Colossal dielectric constants in single-crystalline and ceramic CaCu3Ti4O12 investigated by broadband dielectric spectroscopy

NASA Astrophysics Data System (ADS)

Krohns, S.; Lunkenheimer, P.; Ebbinghaus, S. G.; Loidl, A.

2008-04-01

In the present work, the authors report results of broadband dielectric spectroscopy on various samples of CaCu3Ti4O12 (CCTO), also including single-crystalline material, which so far was only rarely investigated. The measurements extend up to 1.3 GHz, covering more than nine frequency decades. We address the question of the origin of the colossal dielectric constants and of the relaxational behavior in this material, including the second relaxation reported in several recent works. For this purpose, the dependence of the temperature- and frequency-dependent dielectric properties on different tempering and surface treatments of the samples and on ac-field amplitude is investigated. Broadband spectra of a single crystal are analyzed by an equivalent circuit description by assuming two highly resistive layers in series to the bulk. Good fits could be achieved, including the second relaxation, which also shows up in single crystals. The temperature- and frequency-dependent intrinsic conductivity of CCTO is consistent with the variable range hopping model. The second relaxation is sensitive to surface treatment and, in contrast to the main relaxation, is also strongly affected by the applied ac voltage. Concerning the origin of the two insulating layers, we discuss a completely surface-related mechanism by assuming the formation of a metal-insulator diode and a combination of surface and internal barriers.

Chaos-assisted broadband momentum transformation in optical microresonators

NASA Astrophysics Data System (ADS)

Jiang, Xuefeng; Shao, Linbo; Zhang, Shu-Xin; Yi, Xu; Wiersig, Jan; Wang, Li; Gong, Qihuang; Lončar, Marko; Yang, Lan; Xiao, Yun-Feng

2017-10-01

The law of momentum conservation rules out many desired processes in optical microresonators. We report broadband momentum transformations of light in asymmetric whispering gallery microresonators. Assisted by chaotic motions, broadband light can travel between optical modes with different angular momenta within a few picoseconds. Efficient coupling from visible to near-infrared bands is demonstrated between a nanowaveguide and whispering gallery modes with quality factors exceeding 10 million. The broadband momentum transformation enhances the device conversion efficiency of the third-harmonic generation by greater than three orders of magnitude over the conventional evanescent-wave coupling. The observed broadband and fast momentum transformation could promote applications such as multicolor lasers, broadband memories, and multiwavelength optical networks.

Moment tensor inversions using strong motion waveforms of Taiwan TSMIP data, 1993–2009

USGS Publications Warehouse

Chang, Kaiwen; Chi, Wu-Cheng; Gung, Yuancheng; Dreger, Douglas; Lee, William H K.; Chiu, Hung-Chie

2011-01-01

Earthquake source parameters are important for earthquake studies and seismic hazard assessment. Moment tensors are among the most important earthquake source parameters, and are now routinely derived using modern broadband seismic networks around the world. Similar waveform inversion techniques can also apply to other available data, including strong-motion seismograms. Strong-motion waveforms are also broadband, and recorded in many regions since the 1980s. Thus, strong-motion data can be used to augment moment tensor catalogs with a much larger dataset than that available from the high-gain, broadband seismic networks. However, a systematic comparison between the moment tensors derived from strong motion waveforms and high-gain broadband waveforms has not been available. In this study, we inverted the source mechanisms of Taiwan earthquakes between 1993 and 2009 by using the regional moment tensor inversion method using digital data from several hundred stations in the Taiwan Strong Motion Instrumentation Program (TSMIP). By testing different velocity models and filter passbands, we were able to successfully derive moment tensor solutions for 107 earthquakes of Mw >= 4.8. The solutions for large events agree well with other available moment tensor catalogs derived from local and global broadband networks. However, for Mw = 5.0 or smaller events, we consistently over estimated the moment magnitudes by 0.5 to 1.0. We have tested accelerograms, and velocity waveforms integrated from accelerograms for the inversions, and found the results are similar. In addition, we used part of the catalogs to study important seismogenic structures in the area near Meishan Taiwan which was the site of a very damaging earthquake a century ago, and found that the structures were dominated by events with complex right-lateral strike-slip faulting during the recent decade. The procedures developed from this study may be applied to other strong-motion datasets to compliment or fill gaps in catalogs from regional broadband networks and teleseismic networks.

The NEPTUNE Canada Seismograph Network

NASA Astrophysics Data System (ADS)

Rogers, G. C.; Meldrum, R.; Baldwin, R.; Rosenberger, A.; Mulder, T.

2009-12-01

NEPTUNE Canada is the world’s first large regional cable-linked, multi-disciplinary scientific seafloor observatory. In the fall of 2007 an 800 kilometer ring of powered fibre optic cable was laid on the seafloor over the northern part of the Juan de Fuca plate and connected to a shore facility near Port Alberni on Vancouver Island. Five nodes were attached to the cable in the early in the summer of 2009 paving the way for junction boxes and scientific instruments installed in the late summer and fall. The NEPTUNE Canada Seismograph Network will consist initially of four broadband and four short period seismic systems. In the summer of 2009, three broadband OBS packages were deployed forming a large triangle with apexes at ODP 1027 in mid plate and two sites on the continental slope, ODP 889 and Barkley Canyon. In summer 2010 an additional broadband package will be installed on the Endeavour segment of the Juan de Fuca Ridge, and four short period instruments will be installed nearby forming a small array, 6 km in maximum dimension, to record earthquake activity in the vicinity of the many multidisciplinary ridge experiments. The broadband systems comprise a broadband seismometer and strong motion accelerometer in a surficially buried spherical titanium case, with a current meter, hydrophone and differential pressure gauge deployed nearby. The short period systems will include 3-component corehole seismometers on long term loan from the Monterey Bay Aquarium Research Institute (MBARI). All systems will have backup capacity for modest cable outages. The NEPTUNE Canada Seismograph Network relies heavily on knowledge gained from the previous seismographs temporarily deployed in the region by MBARI and the University of Washington and will re-occupy the broadband site and three short period sites at the ridge. NEPTUNE Canada seismic data will be archived by, and available from, both the Geological Survey of Canada and IRIS.

Turbulence Associated With Broadband Shock Noise in Hot Jets

NASA Technical Reports Server (NTRS)

Bridges, James E.; Wernet, Mark P.

2008-01-01

Time-Resolved Particle Image Velocimetry (TRPIV) has been applied to a series of jet flows to measure turbulence statistics associated with broadband shock associated noise (BBSN). Data were acquired in jets of Mach numbers 1.05, 1.185, and 1.4 at different temperatures. Both convergent and ideally expanded nozzles were tested, along with a convergent nozzle modified to minimize screech. Key findings include the effect of heat on shock structure and jet decay, the increase in turbulent velocity when screech is present, and the relative lack of spectral detail associated with the enhanced turbulence.

Wind turbine acoustics

NASA Technical Reports Server (NTRS)

Hubbard, Harvey H.; Shepherd, Kevin P.

1990-01-01

Available information on the physical characteristics of the noise generated by wind turbines is summarized, with example sound pressure time histories, narrow- and broadband frequency spectra, and noise radiation patterns. Reviewed are noise measurement standards, analysis technology, and a method of characterizing wind turbine noise. Prediction methods are given for both low-frequency rotational harmonics and broadband noise components. Also included are atmospheric propagation data showing the effects of distance and refraction by wind shear. Human perception thresholds, based on laboratory and field tests, are given. Building vibration analysis methods are summarized. The bibliography of this report lists technical publications on all aspects of wind turbine acoustics.

Optimization and photomodification of extremely broadband optical response of plasmonic core-shell obscurants.

PubMed

de Silva, Vashista C; Nyga, Piotr; Drachev, Vladimir P

2016-12-15

Plasmonic resonances of the metallic shells depend on their nanostructure and geometry of the core, which can be optimized for the broadband extinction normalized by mass. The fractal nanostructures can provide a broadband extinction. It allows as well for a laser photoburning of holes in the extinction spectra and consequently windows of transparency in a controlled manner. The studied core-shell microparticles synthesized using colloidal chemistry consist of gold fractal nanostructures grown on precipitated calcium carbonate (PCC) microparticles or silica (SiO 2 ) microspheres. The optimization includes different core sizes and shapes, and shell nanostructures. It shows that the rich surface of the PCC flakes is the best core for the fractal shells providing the highest mass normalized extinction over the extremely broad spectral range. The mass normalized extinction cross section up to 3m 2 /g has been demonstrated in the broad spectral range from the visible to mid-infrared. Essentially, the broadband response is a characteristic feature of each core-shell microparticle in contrast to a combination of several structures resonant at different wavelengths, for example nanorods with different aspect ratios. The photomodification at an IR wavelength makes the window of transparency at the longer wavelength side. Copyright © 2016 Elsevier Inc. All rights reserved.

Broadband light-emitting diode

DOEpatents

Fritz, Ian J.; Klem, John F.; Hafich, Michael J.

1998-01-01

A broadband light-emitting diode. The broadband light-emitting diode (LED) comprises a plurality of III-V compound semiconductor layers grown on a semiconductor substrate, with the semiconductor layers including a pair of cladding layers sandwiched about a strained-quantum-well active region having a plurality of different energy bandgaps for generating light in a wavelength range of about 1.3-2 .mu.m. In one embodiment of the present invention, the active region may comprise a first-grown quantum-well layer and a last-grown quantum-well layer that are oppositely strained; whereas in another embodiment of the invention, the active region is formed from a short-period superlattice structure (i.e. a pseudo alloy) comprising alternating thin layers of InGaAs and InGaAlAs. The use a short-period superlattice structure for the active region allows different layers within the active region to be simply and accurately grown by repetitively opening and closing one or more shutters in an MBE growth apparatus to repetitively switch between different growth states therein. The broadband LED may be formed as either a surface-emitting LED or as an edge-emitting LED for use in applications such as chemical sensing, fiber optic gyroscopes, wavelength-division-multiplexed (WDM) fiber-optic data links, and WDM fiber-optic sensor networks for automobiles and aircraft.

Broadband light-emitting diode

DOEpatents

Fritz, I.J.; Klem, J.F.; Hafich, M.J.

1998-07-14

A broadband light-emitting diode is disclosed. The broadband light-emitting diode (LED) comprises a plurality of III-V compound semiconductor layers grown on a semiconductor substrate, with the semiconductor layers including a pair of cladding layers sandwiched about a strained-quantum-well active region having a plurality of different energy bandgaps for generating light in a wavelength range of about 1.3--2 {micro}m. In one embodiment of the present invention, the active region may comprise a first-grown quantum-well layer and a last-grown quantum-well layer that are oppositely strained; whereas in another embodiment of the invention, the active region is formed from a short-period superlattice structure (i.e. a pseudo alloy) comprising alternating thin layers of InGaAs and InGaAlAs. The use a short-period superlattice structure for the active region allows different layers within the active region to be simply and accurately grown by repetitively opening and closing one or more shutters in an MBE growth apparatus to repetitively switch between different growth states therein. The broadband LED may be formed as either a surface-emitting LED or as an edge-emitting LED for use in applications such as chemical sensing, fiber optic gyroscopes, wavelength-divisionmultiplexed (WDM) fiber-optic data links, and WDM fiber-optic sensor networks for automobiles and aircraft. 10 figs.

The Evolution of South Korea's Broadband Convergence Network, 2004-2007

ERIC Educational Resources Information Center

Menon, Siddhartha Shankar

2010-01-01

Broadband holds a critical position in the progress of economic and social indicators by connecting consumers, businesses and governments. South Korea has consistently been the global leader in broadband deployment since 1999. In the last ten years the Korean government has pursued several strategies for its broadband policy. The purpose of this…

Evasion of Complement-Mediated Lysis and Complement C3 Deposition Are Regulated by Francisella tularensis Lipopolysaccharide O Antigen1

PubMed Central

Clay, Corey D.; Soni, Shilpa; Gunn, John S.; Schlesinger, Larry S.

2009-01-01

The bacterium Francisella tularensis (Ft) is a potential weapon of bioterrorism when aerosolized. Macrophage infection is necessary for disease progression and efficient phagocytosis by human macrophages requires serum opsonization by complement. Microbial complement activation leads to surface deposition of a highly regulated protein complex resulting in opsonization or membrane lysis. The nature of complement component C3 deposition, i.e., C3b (opsonization and lysis) or C3bi (opsonization only) fragment deposition, is central to the outcome of activation. In this study, we examine the mechanisms of Ft resistance to complement-mediated lysis, C3 component deposition on the Ft surface, and complement activation. Upon incubation in fresh nonimmune human serum, Schu S4 (Ft subsp. tularensis), Fn (Ft subsp. novicida), and LVS (Ft subsp. holarctica live vaccine strain) were resistant to complement-mediated lysis, but LVSG and LVSR (LVS strains altered in surface carbohydrate structures) were susceptible. C3 deposition, however, occurred on all strains. Complement-susceptible strains had markedly increased C3 fragment deposition, including the persistent presence of C3b compared with C3bi, which indicates that C3b inactivation results in survival of complement-resistant strains. C1q, an essential component of the classical activation pathway, was necessary for lysis of complement-susceptible strains and optimal C3 deposition on all strains. Finally, use of Francisella LPS mutants confirmed O Ag as a major regulator of complement resistance. These data provide evidence that pathogenic Francisella activate complement, but are resistant to complement-mediated lysis in part due to limited C3 deposition, rapid conversion of surface-bound C3b to C3bi, and the presence of LPS O Ag. PMID:18832715

Blood SC5b-9 complement levels increase at parturition during term and preterm labor.

PubMed

Segura-Cervantes, Enrique; Mancilla-Ramirez, Javier; Zurita, Luis; Paredes, Yuriria; Arredondo, José Luis; Galindo-Sevilla, Norma

2015-06-01

We explored the hypothesis that complement, an innate and adaptive immune effector, is active in the plasma of parturient women and is deposited on fetal membranes collected after delivery. A cross-sectional study was designed to evaluate complement activity at parturition. Pregnant women (n = 97) between 15 and 41 years of age were enrolled in a hospital protocol during the perinatal period to assess both SC5b-9 complement activity in blood and complement deposition on fetal membranes during parturition. Soluble SC5b-9 complement activity in plasma fractions was measured using a standard enzyme-linked immunosorbent assay (ELISA) that included specific anti-complement antibodies. Complement deposition on membranes was analyzed using immuno-dot blots and immunohistochemistry. Soluble SC5b-9 complement complex levels were increased in the plasma of women during term labor (TL; median 3361; range 1726-5670 ng/mL), preterm labor (PL; median 2958; range 1552-7092 ng/mL), and preterm premature rupture of membranes (PPROM; median 2272; range 167-6540 ng/mL) compared with pregnant women who were not in labor (P; median 1384; range 174-4570 ng/mL; P < 0.001, Kruskal-Wallis test). Active complement, as assessed by the C9 neo-antigen in C5b-9 complexes, was deposited on fetal membranes, with no difference between term and preterm delivery. The deposition of active complement on fetal membranes was confirmed by immunohistochemistry. Women who underwent non-labor-indicated Cesarean sections did not exhibit complement deposition. Soluble SC5b-9 complement complex levels increased in the plasma of women during parturition, and complement C5b-9 complexes were deposited on fetal membranes. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Complement in Lupus Nephritis: New Perspectives.

PubMed

Bao, Lihua; Cunningham, Patrick N; Quigg, Richard J

2015-09-01

Systemic lupus erythematosus (SLE) is an autoimmune disorder caused by loss of tolerance to self-antigens, the production of autoantibodies and deposition of complement-fixing immune complexes (ICs) in injured tissues. SLE is characterized by a wide range of clinical manifestations and targeted organs, with lupus nephritis being one of the most serious complications. The complement system consists of three pathways and is tightly controlled by a set of regulatory proteins to prevent injudicious complement activation on host tissue. The involvement of the complement system in the pathogenesis of SLE is well accepted; yet, its exact role is still not clear. Complement plays dual roles in the pathogenesis of SLE. On the one hand, the complement system appears to have protective features in that hereditary homozygous deficiencies of classical pathway components, such as C1q and C4, are associated with an increased risk for SLE. On the other hand, IC-mediated activation of complement in affected tissues is clearly evident in both experimental and human SLE along with pathological features that are logical consequences of complement activation. Studies in genetically altered mice have shown that lack of complement inhibitors, such as complement factor H (CFH) or decay-accelerating factor (DAF) accelerates the development of experimental lupus nephritis, while treatment with recombinant protein inhibitors, such as Crry-Ig, CR2-Crry, CR2-DAF and CR2-CFH, ameliorates the disease development. Complement-targeted drugs, including soluble complement receptor 1 (TP10), C1 esterase inhibitor and a monoclonal anti-C5 antibody (eculizumab), have been shown to inhibit complement safely, and are now being investigated in a variety of clinical conditions. SLE is an autoimmune disorder which targets multiple systems. Complement is centrally involved and plays dual roles in the pathogenesis of SLE. Studies from experimental lupus models and clinical trials support the use of complement-targeted therapy in the treatment of SLE.

First NuSTAR Observations of Mrk 501 within a Radio to TeV Multi-Instrument Campaign

DOE PAGES

Furniss, Amy

2015-10-08

We report on simultaneous broadband observations of the TeV-emitting blazar Markarian 501 between 2013 April 1 and August 10, including the first detailed characterization of the synchrotron peak with Swift and NuSTAR. During the campaign, the nearby BL Lac object was observed in both a quiescent and an elevated state. The broadband campaign includes observations with NuSTAR, MAGIC, VERITAS, the Fermi Large Area Telescope, Swift X-ray Telescope and UV Optical Telescope, various ground-based optical instruments, including the GASP-WEBT program, as well as radio observations by OVRO, Metsähovi, and the F-Gamma consortium. Some of the MAGIC observations were affected by amore » sand layer from the Saharan desert, and had to be corrected using event-by-event corrections derived with a Light Detection and Ranging (LIDAR) facility. This is the first time that LIDAR information is used to produce a physics result with Cherenkov Telescope data taken during adverse atmospheric conditions, and hence sets a precedent for the current and future ground-based gamma-ray instruments. The NuSTAR instrument provides unprecedented sensitivity in hard X-rays, showing the source to display a spectral energy distribution (SED) between 3 and 79 keV consistent with a log-parabolic spectrum and hard X-ray variability on hour timescales. None (of the four extended NuSTAR observations) show evidence of the onset of inverse-Compton emission at hard X-ray energies. We apply a single-zone equilibrium synchrotron self-Compton (SSC) model to five simultaneous broadband SEDs. We find that the SSC model can reproduce the observed broadband states through a decrease in the magnetic field strength coinciding with an increase in the luminosity and hardness of the relativistic leptons responsible for the high-energy emission.« less

FIRST NuSTAR OBSERVATIONS OF MRK 501 WITHIN A RADIO TO TeV MULTI-INSTRUMENT CAMPAIGN

DOE Office of Scientific and Technical Information (OSTI.GOV)

Furniss, A.; Noda, K.; Boggs, S.

2015-10-10

We report on simultaneous broadband observations of the TeV-emitting blazar Markarian 501 between 2013 April 1 and August 10, including the first detailed characterization of the synchrotron peak with Swift and NuSTAR. During the campaign, the nearby BL Lac object was observed in both a quiescent and an elevated state. The broadband campaign includes observations with NuSTAR, MAGIC, VERITAS, the Fermi Large Area Telescope, Swift X-ray Telescope and UV Optical Telescope, various ground-based optical instruments, including the GASP-WEBT program, as well as radio observations by OVRO, Metsähovi, and the F-Gamma consortium. Some of the MAGIC observations were affected by amore » sand layer from the Saharan desert, and had to be corrected using event-by-event corrections derived with a Light Detection and Ranging (LIDAR) facility. This is the first time that LIDAR information is used to produce a physics result with Cherenkov Telescope data taken during adverse atmospheric conditions, and hence sets a precedent for the current and future ground-based gamma-ray instruments. The NuSTAR instrument provides unprecedented sensitivity in hard X-rays, showing the source to display a spectral energy distribution (SED) between 3 and 79 keV consistent with a log-parabolic spectrum and hard X-ray variability on hour timescales. None (of the four extended NuSTAR observations) show evidence of the onset of inverse-Compton emission at hard X-ray energies. We apply a single-zone equilibrium synchrotron self-Compton (SSC) model to five simultaneous broadband SEDs. We find that the SSC model can reproduce the observed broadband states through a decrease in the magnetic field strength coinciding with an increase in the luminosity and hardness of the relativistic leptons responsible for the high-energy emission.« less

Local Earthquake P-wave Tomography at Mount St. Helens with the iMUSH Broadband Array

NASA Astrophysics Data System (ADS)

Ulberg, C. W.; Creager, K. C.; Moran, S. C.; Abers, G. A.; Crosbie, K.; Crosson, R. S.; Denlinger, R. P.; Thelen, W. A.; Hansen, S. M.; Schmandt, B.; Kiser, E.; Levander, A.; Bachmann, O.

2016-12-01

We deployed 70 broadband seismometers in the summer of 2014 to image the seismic velocity structure beneath Mount St. Helens (MSH), Washington, as part of the collaborative imaging Magma Under St. Helens (iMUSH) project. Our goal is to illuminate the MSH magmatic system by integrating all portions of the iMUSH experiment, including active- and passive-source tomography, ambient-noise tomography, seismicity, receiver functions, magnetotellurics, and petrology. The broadband array has a diameter of 100 km centered on MSH with an average station spacing of 10 km, and was deployed through summer 2016. It is augmented by dozens of permanent stations in the area. We determine P-wave arrival times and also incorporate picks from the permanent network. There were more than 250 local events during the first year of iMUSH broadband recording, which have provided over 11,000 high-quality arrival times. The iMUSH experiment included 23 active shots in 2014 that were recorded with good signal-to-noise ratios across the entire array. Direct raypaths from local earthquakes and active shots reach 15-20 km depth beneath MSH. We use the program struct3DP to iteratively invert travel times to obtain a 3-D seismic velocity model and relocate hypocenters. Travel times are computed using a 3-D eikonal-equation solver. We are expanding our analysis to include S-wave arrivals from local events. The preliminary 3-D model shows low P-wave speeds along the St. Helens seismic zone, striking NNW-SSE of MSH from near the surface to where we lose resolution at 15-20km depth. This seismic zone coincides with a sharp boundary in Moho reflectivity that has been interpreted as the eastern boundary of a serpentinized mantle wedge (Hansen et al, 2016, submitted). We speculate that the seismic zone and low wave speeds are related to fluids rising from the eastern boundary of the wedge.

Prediction of inflammatory responses induced by biomaterials in contact with human blood using protein fingerprint from plasma.

PubMed

Engberg, Anna E; Nilsson, Per H; Huang, Shan; Fromell, Karin; Hamad, Osama A; Mollnes, Tom Eirik; Rosengren-Holmberg, Jenny P; Sandholm, Kerstin; Teramura, Yuji; Nicholls, Ian A; Nilsson, Bo; Ekdahl, Kristina N

2015-01-01

Inappropriate complement activation is often responsible for incompatibility reactions that occur when biomaterials are used. Complement activation is therefore a criterion included in legislation regarding biomaterials testing. However, no consensus is yet available regarding appropriate complement-activation-related test parameters. We examined protein adsorption in plasma and complement activation/cytokine release in whole blood incubated with well-characterized polymers. Strong correlations were found between the ratio of C4 to its inhibitor C4BP and generation of 10 (mainly pro-inflammatory) cytokines, including IL-17, IFN-γ, and IL-6. The levels of complement activation products correlated weakly (C3a) or not at all (C5a, sC5b-9), confirming their poor predictive values. We have demonstrated a direct correlation between downstream biological effects and the proteins initially adhering to an artificial surface after contact with blood. Consequently, we propose the C4/C4BP ratio as a robust, predictor of biocompatibility with superior specificity and sensitivity over the current gold standard. Copyright © 2014 Elsevier Ltd. All rights reserved.

76 FR 51271 - Implementing a Nationwide, Broadband, Interoperable Public Safety Network in the 700 MHz Band

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-18

... Docket 07-100; FCC 11-6] Implementing a Nationwide, Broadband, Interoperable Public Safety Network in the... interoperable public safety broadband network. The establishment of a common air interface for 700 MHz public safety broadband networks will create a foundation for interoperability and provide a clear path for the...

Libraries Use Broadband Internet Service to Serve High Need Communities. Data Note. Number 1

ERIC Educational Resources Information Center

Pastore, Erica; Henderson, Everett

2009-01-01

America needs greater access to broadband Internet to spur economic growth, innovation, and job creation. To date, gains in household broadband take-up are not evenly distributed across all demographic groups or geographic areas. While from 2001 to 2007, the percentage of households in the United States with access to broadband Internet services…

A Comprehensive Review of Helicopter Noise Literature

DTIC Science & Technology

1975-06-01

Broadband Noise .... ........................ .0.0.0 13 Impulsive Noise .......... ........... ............... ... *. i Introduction... broadband noise is probably the turbulence in the flow seen by the rotor blades. Trhe prediction of rotor broadband noise based on rotor geometry amd...acoustic processes, but rely on generalization of existing test data. The recent impetus to study broadband noise is the result of reducing

ERBE and CERES broadband scanning radiometers

NASA Technical Reports Server (NTRS)

Weaver, William L.; Cooper, John E.

1990-01-01

Broadband scanning radiometers have been used extensively on earth-orbiting satellites to measure the Earth's outgoing radiation. The resulting estimates of longwave and shortwave fluxes have played an important role in helping to understand the Earth's radiant energy balance or budget. The Clouds and the Earth Radiant Energy System (CERES) experiment is expected to include instruments with three broadband scanning radiometers. The design of the CERES instrument will draw heavily from the flight-proven Earth Radiation Budget Experiment (ERBE) scanner instrument technology and will benefit from the several years of ERBE experience in mission operations and data processing. The discussion starts with a description of the scientific objectives of ERBE and CERES. The design and operational characteristics of the ERBE and CERES instrument are compared and the two ground-based data processing systems are compared. Finally, aspects of the CERES data processing which might be performed in near real-time aboard a spacecraft platform are discussed, and the types of algorithms and input data requirements for the onboard processing system are identified.

A Wide Band Absorbing Material Design Using Band-Pass Frequency Selective Surface

NASA Astrophysics Data System (ADS)

Xu, Yonggang; Xu, Qiang; Liu, Ting; Zheng, Dianliang; Zhou, Li

2018-03-01

Based on the high frequency advantage characteristics of the Fe based absorbing coating, a method for designing the structure of broadband absorbing structure by using frequency selective surface (FSS) is proposed. According to the transmission and reflection characteristic of the different size FSS structure, the frequency variation characteristic was simulated. Secondly, the genetic algorithm was used to optimize the high frequency broadband absorbing materials, including the single and double magnetic layer material. Finally, the absorbing characteristics in iron layer were analyzed as the band pass FSS structure was embedded, the results showed that the band-pass FSS had the influence on widening the absorbing frequency. As the FSS was set as the bottom layer, it was effective to achieve the good absorbing property in low frequency and the high frequency absorbing performance was not weakened, because the band-pass FSS led the low frequency absorption and the high frequency shielding effect. The results of this paper are of guiding significance for designing and manufacturing the broadband absorbing materials.

Progress on Broadband Access to the Internet and Use of Mobile Devices in the United States.

PubMed

Serrano, Katrina J; Thai, Chan L; Greenberg, Alexandra J; Blake, Kelly D; Moser, Richard P; Hesse, Bradford W

Healthy People 2020 (HP2020) aims to improve population health outcomes through several objectives, including health communication and health information technology. We used 7 administrations of the Health Information National Trends Survey to examine HP2020 goals toward access to the Internet through broadband and mobile devices (N = 34 080). We conducted descriptive analyses and obtained predicted marginals, also known as model-adjusted risks, to estimate the association between demographic characteristics and use of mobile devices. The HP2020 target (7.7% of the US population) for accessing the Internet through a cellular network was surpassed in 2014 (59.7%), but the HP2020 target (83.2%) for broadband access fell short (63.8%). Sex and age were associated with accessing the Internet through a cellular network throughout the years (Wald F test, P <.05). The increase in the percentage of people accessing the Internet through mobile devices presents an opportunity for technology-based health interventions that should be explored.

Progress on Broadband Access to the Internet and Use of Mobile Devices in the United States

PubMed Central

Thai, Chan L.; Greenberg, Alexandra J.; Blake, Kelly D.; Moser, Richard P.; Hesse, Bradford W.

2016-01-01

Healthy People 2020 (HP2020) aims to improve population health outcomes through several objectives, including health communication and health information technology. We used 7 administrations of the Health Information National Trends Survey to examine HP2020 goals toward access to the Internet through broadband and mobile devices (N = 34 080). We conducted descriptive analyses and obtained predicted marginals, also known as model-adjusted risks, to estimate the association between demographic characteristics and use of mobile devices. The HP2020 target (7.7% of the US population) for accessing the Internet through a cellular network was surpassed in 2014 (59.7%), but the HP2020 target (83.2%) for broadband access fell short (63.8%). Sex and age were associated with accessing the Internet through a cellular network throughout the years (Wald F test, P <.05). The increase in the percentage of people accessing the Internet through mobile devices presents an opportunity for technology-based health interventions that should be explored. PMID:28005473

Winds from Luminous Late-Type Stars: II. Broadband Frequency Distribution of Alfven Waves

NASA Technical Reports Server (NTRS)

Airapetian, V.; Carpenter, K. G.; Ofman, L.

2010-01-01

We present the numerical simulations of winds from evolved giant stars using a fully non-linear, time dependent 2.5-dimensional magnetohydrodynamic (MHD) code. This study extends our previous fully non-linear MHD wind simulations to include a broadband frequency spectrum of Alfven waves that drive winds from red giant stars. We calculated four Alfven wind models that cover the whole range of Alfven wave frequency spectrum to characterize the role of freely propagated and reflected Alfven waves in the gravitationally stratified atmosphere of a late-type giant star. Our simulations demonstrate that, unlike linear Alfven wave-driven wind models, a stellar wind model based on plasma acceleration due to broadband non-linear Alfven waves, can consistently reproduce the wide range of observed radial velocity profiles of the winds, their terminal velocities and the observed mass loss rates. Comparison of the calculated mass loss rates with the empirically determined mass loss rate for alpha Tau suggests an anisotropic and time-dependent nature of stellar winds from evolved giants.

Reference Interferometer Using a Semiconductor Laser/LED Reference Source in a Cryogenic Fourier-Transform Spectrometer

NASA Technical Reports Server (NTRS)

Martino, Anthony J.; Cornwell, Donald M.

1998-01-01

A combination of a single mode AlGaAs laser diode and broadband LED was used in a Michelson interferometer to provide reference signals in a Fourier transform spectrometer, the Composite Infrared Spectrometer, on the Cassini mission to Saturn. The narrowband light from the laser produced continuous fringes throughout the travel of the interferometer, which were used to control the velocity of the scan mechanism and to trigger data sampling. The broadband light from the LED produced a burst of fringes at zero path difference, which was used as a fixed position reference. The system, including the sources, the interferometer, and the detectors, was designed to work both at room temperature and instrument operating temperature of 170 Kelvin. One major challenge that was overcome was preservation, from room temperature to 170 K, of alignment sufficient for high modulation of fringes from the broadband source. Another was the shift of the source spectra about 30 nm toward shorter wavelengths upon cooldown.

Complement System Part II: Role in Immunity

PubMed Central

Merle, Nicolas S.; Noe, Remi; Halbwachs-Mecarelli, Lise; Fremeaux-Bacchi, Veronique; Roumenina, Lubka T.

2015-01-01

The complement system has been considered for a long time as a simple lytic cascade, aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it is well accepted that complement is a complex innate immune surveillance system, playing a key role in host homeostasis, inflammation, and in the defense against pathogens. This review discusses recent advances in the understanding of the role of complement in physiology and pathology. It starts with a description of complement contribution to the normal physiology (homeostasis) of a healthy organism, including the silent clearance of apoptotic cells and maintenance of cell survival. In pathology, complement can be a friend or a foe. It acts as a friend in the defense against pathogens, by inducing opsonization and a direct killing by C5b–9 membrane attack complex and by triggering inflammatory responses with the anaphylatoxins C3a and C5a. Opsonization plays also a major role in the mounting of an adaptive immune response, involving antigen presenting cells, T-, and B-lymphocytes. Nevertheless, it can be also an enemy, when pathogens hijack complement regulators to protect themselves from the immune system. Inadequate complement activation becomes a disease cause, as in atypical hemolytic uremic syndrome, C3 glomerulopathies, and systemic lupus erythematosus. Age-related macular degeneration and cancer will be described as examples showing that complement contributes to a large variety of conditions, far exceeding the classical examples of diseases associated with complement deficiencies. Finally, we discuss complement as a therapeutic target. PMID:26074922

Ambient seismic noise levels: A survey of the permanent and temporary seismographic networks in Morocco, North Africa

NASA Astrophysics Data System (ADS)

El Fellah, Y.; Khairy Abd Ed-Aal, A.; El Moudnib, L.; Mimoun, H.; Villasenor, A.; Gallart, J.; Thomas, C.; Elouai, D.; Mimoun, C.; Himmi, M.

2013-12-01

Abstract The results, of a conducted study carried out to analyze variations in ambient seismic noise levels at sites of the installed broadband stations in Morocco, North Africa, are obtained. The permanent and the temporary seismic stations installed in Morocco of the Scientific Institute ( IS, Rabat, Morocco), institute de Ciencias de la Tierra Jaume almera (ICTJA, Barcelona, Spain) and Institut für Geophysik (Munster, Germany) were used in this study. In this work, we used 23 broadband seismic stations installed in different structural domains covering all Morocco from south to north. The main purposes of the current study are: 1) to present a catalog of seismic background noise spectra for Morocco obtained from recently installed broadband stations, 2) to assess the effects of experimental temporary seismic vault construction, 3) to determine the time needed for noise at sites to stabilize, 4) to establish characteristics and origin of seismic noise at those sites. We calculated power spectral densities of background noise for each component of each broadband seismometer deployed in the different investigated sites and then compared them with the high-noise model and low-noise Model of Peterson (1993). All segments from day and night local time windows were included in the calculation without parsing out earthquakes. The obtained results of the current study could be used forthcoming to evaluate permanent station quality. Moreover, this study could be considered as a first step to develop new seismic noise models in North Africa not included in Peterson (1993). Keywords Background noise; Power spectral density; Model of Peterson; Scientific Institute; Institute de Ciencias de la Tierra Jaume almera; Institut für Geophysik

The SCEC Broadband Platform: Open-Source Software for Strong Ground Motion Simulation and Validation

NASA Astrophysics Data System (ADS)

Silva, F.; Goulet, C. A.; Maechling, P. J.; Callaghan, S.; Jordan, T. H.

2016-12-01

The Southern California Earthquake Center (SCEC) Broadband Platform (BBP) is a carefully integrated collection of open-source scientific software programs that can simulate broadband (0-100 Hz) ground motions for earthquakes at regional scales. The BBP can run earthquake rupture and wave propagation modeling software to simulate ground motions for well-observed historical earthquakes and to quantify how well the simulated broadband seismograms match the observed seismograms. The BBP can also run simulations for hypothetical earthquakes. In this case, users input an earthquake location and magnitude description, a list of station locations, and a 1D velocity model for the region of interest, and the BBP software then calculates ground motions for the specified stations. The BBP scientific software modules implement kinematic rupture generation, low- and high-frequency seismogram synthesis using wave propagation through 1D layered velocity structures, several ground motion intensity measure calculations, and various ground motion goodness-of-fit tools. These modules are integrated into a software system that provides user-defined, repeatable, calculation of ground-motion seismograms, using multiple alternative ground motion simulation methods, and software utilities to generate tables, plots, and maps. The BBP has been developed over the last five years in a collaborative project involving geoscientists, earthquake engineers, graduate students, and SCEC scientific software developers. The SCEC BBP software released in 2016 can be compiled and run on recent Linux and Mac OS X systems with GNU compilers. It includes five simulation methods, seven simulation regions covering California, Japan, and Eastern North America, and the ability to compare simulation results against empirical ground motion models (aka GMPEs). The latest version includes updated ground motion simulation methods, a suite of new validation metrics and a simplified command line user interface.

Human L-ficolin, a recognition molecule of the lectin activation pathway of complement, activates complement by binding to pneumolysin, the major toxin of Streptococcus pneumoniae.

PubMed

Ali, Youssif M; Kenawy, Hany I; Muhammad, Adnan; Sim, Robert B; Andrew, Peter W; Schwaeble, Wilhelm J

2013-01-01

The complement system is an essential component of the immune response, providing a critical line of defense against different pathogens including S. pneumoniae. Complement is activated via three distinct pathways: the classical (CP), the alternative (AP) and the lectin pathway (LP). The role of Pneumolysin (PLY), a bacterial toxin released by S. pneumoniae, in triggering complement activation has been studied in vitro. Our results demonstrate that in both human and mouse sera complement was activated via the CP, initiated by direct binding of even non-specific IgM and IgG3 to PLY. Absence of CP activity in C1q(-/-) mouse serum completely abolished any C3 deposition. However, C1q depleted human serum strongly opsonized PLY through abundant deposition of C3 activation products, indicating that the LP may have a vital role in activating the human complement system on PLY. We identified that human L-ficolin is the critical LP recognition molecule that drives LP activation on PLY, while all of the murine LP recognition components fail to bind and activate complement on PLY. This work elucidates the detailed interactions between PLY and complement and shows for the first time a specific role of the LP in PLY-mediated complement activation in human serum.

Human L-ficolin, a Recognition Molecule of the Lectin Activation Pathway of Complement, Activates Complement by Binding to Pneumolysin, the Major Toxin of Streptococcus pneumoniae

PubMed Central

Ali, Youssif M.; Kenawy, Hany I.; Muhammad, Adnan; Sim, Robert B.

2013-01-01

The complement system is an essential component of the immune response, providing a critical line of defense against different pathogens including S. pneumoniae. Complement is activated via three distinct pathways: the classical (CP), the alternative (AP) and the lectin pathway (LP). The role of Pneumolysin (PLY), a bacterial toxin released by S. pneumoniae, in triggering complement activation has been studied in vitro. Our results demonstrate that in both human and mouse sera complement was activated via the CP, initiated by direct binding of even non-specific IgM and IgG3 to PLY. Absence of CP activity in C1q−/− mouse serum completely abolished any C3 deposition. However, C1q depleted human serum strongly opsonized PLY through abundant deposition of C3 activation products, indicating that the LP may have a vital role in activating the human complement system on PLY. We identified that human L-ficolin is the critical LP recognition molecule that drives LP activation on PLY, while all of the murine LP recognition components fail to bind and activate complement on PLY. This work elucidates the detailed interactions between PLY and complement and shows for the first time a specific role of the LP in PLY-mediated complement activation in human serum. PMID:24349316

Progress and trends in complement therapeutics.

PubMed

Ricklin, Daniel; Lambris, John D

2013-01-01

The past few years have proven to be a highly successful and exciting period for the field of complement-directed drug discovery and development. Driven by promising experiences with the first marketed complement drugs, increased knowledge about the involvement of complement in health and disease, and improvements in structural and analytical techniques as well as animal models of disease, the field has seen a surge in creative approaches to therapeutically intervene at various stages of the cascade. An impressive panel of compounds that show promise in clinical trials is meanwhile being lined up in the pipelines of both small biotechnology and big pharmaceutical companies. Yet with this new focus on complement-targeted therapeutics, important questions concerning target selection, point and length of intervention, safety, and drug delivery emerge. In view of the diversity of the clinical disorders involving abnormal complement activity or regulation, which include both acute and chronic diseases and affect a wide range of organs, diverse yet specifically tailored therapeutic approaches may be needed to shift complement back into balance. This chapter highlights the key changes in the field that shape our current perception of complement-targeted drugs and provides a brief overview of recent strategies and emerging trends. Selected examples of complement-related diseases and inhibitor classes are highlighted to illustrate the diversity and creativity in field.

Progress and Trends in Complement Therapeutics.

PubMed

Ricklin, Daniel; Lambris, John D

2013-01-01

The past few years have proven to be a highly successful and exciting period for the field of complement-directed drug discovery and development. Driven by promising experiences with the first marketed complement drugs, increased knowledge about the involvement of complement in health and disease, and improvements in structural and analytical techniques as well as animal models of disease, the field has seen a surge in creative approaches to therapeutically intervene at various stages of the cascade. An impressive panel of compounds that show promise in clinical trials is meanwhile being lined up in the pipelines of both small biotechnology and big pharmaceutical companies. Yet with this new focus on complement-targeted therapeutics, important questions concerning target selection, point and length of intervention, safety, and drug delivery emerge. In view of the diversity of the clinical disorders involving abnormal complement activity or regulation, which include both acute and chronic diseases and affect a wide range of organs, diverse yet specifically tailored therapeutic approaches may be needed to shift complement back into balance. This chapter highlights the key changes in the field that shape our current perception of complement-targeted drugs and provides a brief overview of recent strategies and emerging trends. Selected examples of complement-related diseases and inhibitor classes are highlighted to illustrate the diversity and creativity in field.

SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis

PubMed Central

Ferreira, Viviana P.; Fazito Vale, Vladimir; Pangburn, Michael K.; Abdeladhim, Maha; Ferreira Mendes-Sousa, Antonio; Coutinho-Abreu, Iliano V.; Rasouli, Manoochehr; Brandt, Elizabeth A.; Meneses, Claudio; Lima, Kolyvan Ferreira; Nascimento Araújo, Ricardo; Horácio Pereira, Marcos; Kotsyfakis, Michalis; Oliveira, Fabiano; Kamhawi, Shaden; Ribeiro, Jose M. C.; Gontijo, Nelder F.; Collin, Nicolas; Valenzuela, Jesus G.

2016-01-01

Blood-feeding insects inject potent salivary components including complement inhibitors into their host’s skin to acquire a blood meal. Sand fly saliva was shown to inhibit the classical pathway of complement; however, the molecular identity of the inhibitor remains unknown. Here, we identified SALO as the classical pathway complement inhibitor. SALO, an 11 kDa protein, has no homology to proteins of any other organism apart from New World sand flies. rSALO anti-complement activity has the same chromatographic properties as the Lu. longipalpis salivary gland homogenate (SGH)counterparts and anti-rSALO antibodies blocked the classical pathway complement activity of rSALO and SGH. Both rSALO and SGH inhibited C4b deposition and cleavage of C4. rSALO, however, did not inhibit the protease activity of C1s nor the enzymatic activity of factor Xa, uPA, thrombin, kallikrein, trypsin and plasmin. Importantly, rSALO did not inhibit the alternative or the lectin pathway of complement. In conclusion our data shows that SALO is a specific classical pathway complement inhibitor present in the saliva of Lu. longipalpis. Importantly, due to its small size and specificity, SALO may offer a therapeutic alternative for complement classical pathway-mediated pathogenic effects in human diseases. PMID:26758086

The impact of cell culture equipment on energy loss.

PubMed

Davies, Lleucu B; Kiernan, Michael N; Bishop, Joanna C; Thornton, Catherine A; Morgan, Gareth

2014-01-01

Light energy of discrete wavelengths supplied via lasers and broadband intense pulsed light have been used therapeutically for many years. In vitro models complement clinical studies, especially for the elucidation of underlying mechanisms of action. Clarification that light energy reaches the cells is necessary when developing protocols for the treatment of cells using in vitro models. Few studies report on energy loss in cell culture equipment. The ability of energy from light with therapeutic potential to reach cells in culture needs to be determined; this includes determining the proportion of light energy lost within standard cell culture media and cell culture vessels. The energy absorption of cell culture media, with/without the pH indicator dye phenol red, and the loss of energy within different plastics and glassware used typically for in vitro cell culture were investigated using intense pulsed light and a yellow pulsed dye laser. Media containing phenol red have a distinctive absorption peak (560 nm) absent in phenol red-free media and restored by the addition of phenol red. For both light sources, energy loss was lowest in standard polystyrene tissue culture flasks or multi-well plates and highest in polypropylene vessels or glass tubes. The effects of phenol red-free media on the absorption of energy varied with the light source used. Phenol red-free media are the media of choice; polystyrene vessels with flat surfaces such as culture flasks or multi-well plates should be used in preference to polypropylene or glass vessels.

Changes in long-term eruption dynamics at Santiaguito, Guatemala: Observations from seismic data

NASA Astrophysics Data System (ADS)

Lamb, O. D.; Lavallée, Y.; De Angelis, S.; Lamur, A.; Hornby, A. J.; von Aulock, F. W.; Kendrick, J. E.; Chigna, G.; Rietbrock, A.

2016-12-01

Santiaguito (Guatemala) is an ideal laboratory for the study of the eruption dynamics of long-lived silicic eruptions. Here we present seismic observations of ash-and-gas explosions recorded between November 2014 and June 2016 during a multi-disciplinary experiment by the University of Liverpool. The instruments, deployed around the active dome complex between 0.5 to 7 km from the vent, included 5 broadband and 6 short-period seismometers, as well as 5 infrasound sensors. The geophysical data is complemented by thermal images, optical images from a UAV, and geochemical measurements of erupted material. Regular, small-to-moderate sized explosions from the El Caliente dome at Santiaguito have been common since at least the early 1970s. However, in 2015, a shift in character took place in terms of the regularity and magnitude of the explosions. Explosions became larger and less regular, and often accompanied by pyroclastic density currents. The larger explosions have caused a major morphological change at the vent, as a rubble-filled vent was replaced by a crater of 150 m depth. This shift in behaviour likely represents a change in the eruptive mechanism in the upper conduit beneath the Caliente vent, possibly triggered by processes at a greater depth in the volcanic system. This experiment represents a unique opportunity to use multi-disciplinary research to help understand the long-term eruptive dynamics of lava dome eruptions. Our observations may have implications for hazard assessment not only at Santiaguito, but at many other volcanic systems worldwide.

On the suitability of broadband attenuation measurement for characterizing contrast microbubbles.

PubMed

Chatterjee, Dhiman; Sarkar, Kausik; Jain, Pankaj; Schreppler, Nathan E

2005-06-01

Broadband attenuation measurement has been widely used for characterizing ultrasound contrast agents. Chen et al. (2002) recently suggested that broadband attenuation data depend on the center frequency of the broadband excitation pulse and, therefore, that they are not a reliable measure of the bubble behavior. We investigated the suitability of measurement of broadband attenuation as a characterizing tool using the contrast agent Definity as a test case. Analyzing the attenuation data obtained with three broadband unfocused transducers with different center frequencies (2.25, 3.5 and 5 MHz), we found that attenuation is independent of the transducer used and matches in the overlap regions of any two transducers. Attenuation does not depend on excitation pressure amplitude as long as the excitation amplitude remains below a critical value ( approximately 0.26 MPa), indicating that the measurement of broadband attenuation below critical excitation can, indeed, be used for characterization. Furthermore, the linear relationship of attenuation with concentrations of Definity is also investigated.

Near-Infrared photometry of BOs and Centaurs in support of Spitzer Space Telescope data

NASA Astrophysics Data System (ADS)

Pinilla-Alonso, Noemi; Emery, Josh P.; Trilling, David; Mommert, Michael

2014-08-01

We propose to measure near-infrared broadband colors of Centaurs and Kuiper Belt objects (KBOs). The proposed ground-based observations will complement 3.6 and 4.5 microns photometry of these bodies obtained with the Infrared Array Camera (IRAC) on the Spitzer Space Telescope. Extending reflectances past 2.5 micron with Spitzer enables sensitive searches for absorptions in the 3 to 5 micron region, where relevant species (e.g., complex organics, H2O, CO2, CH4, hydrated silicates) have their fundamental absorption bands. In order to assess the presence of absorptions, however, the Spitzer photometry must be tied to shorter wavelength near-infrared reflectances. Recently, Wright et al. (2012) combined IRAC/Spitzer and NIR colors for a sample of cold KBOs and showed how powerful this technique is detecting the presence of volatiles. In semester 2011B we obtained Gemini NIR data for 12 KBOs (results were presented in the DPS Meeting 2012 and part is included in the Master Dissertation of D. Wright, under the supervision of J.P. Emery). In semester 2011B and 2013A we obtained Gemini NIR data for 12 and 7 KBOs respectively (part of these results were presented in the DPS Meeting 2012 and part is included in the Master Dissertation of D. Wright, under the supervision of J.P. Emery). But our sample is not yet completed and we need more time to complete our study and cover a larger number of targets from our sample of Spitzer data. Approximately 54 objects in our sample that lack NIR colors are visible from GEMINI South in 2014B semester, we propose here to observe 16 of these objects.

Using the Freiburg Acuity and Contrast Test to measure visual performance in USAF personnel after PRK.

PubMed

Dennis, Richard J; Beer, Jeremy M A; Baldwin, J Bruce; Ivan, Douglas J; Lorusso, Frank J; Thompson, William T

2004-07-01

Photorefractive keratectomy (PRK) may be an alternative to spectacle and contact lens wear for United States Air Force (USAF) aircrew and may offer some distinct advantages in operational situations. However, any residual corneal haze or scar formation from PRK could exacerbate the disabling effects of a bright glare source on a complex visual task. The USAF recently completed a longitudinal clinical evaluation of the long-term effects of PRK on visual performance, including the experiment described herein. After baseline data were collected, 20 nonflying active duty USAF personnel underwent PRK. Visual performance was then measured at 6, 12, and 24 months after PRK. Visual acuity (VA) and contrast sensitivity (CS) data were collected by using the Freiburg Acuity and Contrast Test (FrACT), with the subject viewing half of the runs through a polycarbonate windscreen. Experimental runs were completed under 3 glare conditions: no glare source and with either a broadband or a green laser (532-nm) glare annulus (luminance approximately 6090 cd/m) surrounding the Landolt C stimulus. Systematic effects of PRK on VA relative to baseline were not identified. However, VA was almost 2 full Snellen lines worse with the laser glare source in place versus the broadband glare source. A significant drop-off was observed in CS performance after PRK under conditions of no glare and broadband glare; this was the case both with and without the windscreen. As with VA, laser glare disrupted CS performance significantly and more than broadband glare did. PRK does not appear to have affected VA, but the changes in CS might represent a true decline in visual performance. The greater disruptive effects from laser versus broadband glare may be a result of increased masking from coherent spatial noise (speckle) surrounding the laser stimulus.

Gain-assisted broadband ring cavity enhanced spectroscopy

NASA Astrophysics Data System (ADS)

Selim, Mahmoud A.; Adib, George A.; Sabry, Yasser M.; Khalil, Diaa

2017-02-01

Incoherent broadband cavity enhanced spectroscopy can significantly increase the effective path length of light-matter interaction to detect weak absorption lines over broad spectral range, for instance to detect gases in confined environments. Broadband cavity enhancement can be based on the decay time or the intensity drop technique. Decay time measurement is based on using tunable laser source that is expensive and suffers from long scan time. Intensity dependent measurement is usually reported based on broadband source using Fabry-Perot cavity, enabling short measurement time but suffers from the alignment tolerance of the cavity and the cavity insertion loss. In this work we overcome these challenges by using an alignment-free ring cavity made of an optical fiber loop and a directional coupler, while having a gain medium pumped below the lasing threshold to improve the finesse and reduce the insertion loss. Acetylene (C2H2) gas absorption is measured around 1535 nm wavelength using a semiconductor optical amplifier (SOA) gain medium. The system is analyzed for different ring resonator forward coupling coefficient and loses, including the 3-cm long gas cell insertion loss and fiber connector losses used in the experimental verification. The experimental results are obtained for a coupler ratio of 90/10 and a fiber length of 4 m. The broadband source is the amplified spontaneous emission of another SOA and the output is measured using a 70pm-resolution optical spectrum analyzer. The absorption depth and the effective interaction length are improved about an order of magnitude compared to the direct absorption of the gas cell. The presented technique provides an engineering method to improve the finesse and, consequently the effective length, while relaxing the technological constraints on the high reflectivity mirrors and free-space cavity alignment.

Going Digital in Rural America.

ERIC Educational Resources Information Center

Malecki, Edward J.

This paper examines the extent to which rural America is digital--has access to the Internet and to newer technologies such as wireless broadband--and discusses rural supply and demand for "going digital." Supply aspects include issues of both infrastructure and public policy. Demand aspects include entrepreneurs (business users) and…

Applications of geophysical methods to volcano monitoring

USGS Publications Warehouse

Wynn, Jeff; Dzurisin, Daniel; Finn, Carol A.; Kauahikaua, James P.; Lahusen, Richard G.

2006-01-01

The array of geophysical technologies used in volcano hazards studies - some developed originally only for volcano monitoring - ranges from satellite remote sensing including InSAR to leveling and EDM surveys, campaign and telemetered GPS networks, electronic tiltmeters and strainmeters, airborne magnetic and electromagnetic surveys, short-period and broadband seismic monitoring, even microphones tuned for infrasound. They include virtually every method used in resource exploration except large-scale seismic reflection. By “geophysical ” we include both active and passive methods as well as geodetic technologies. Volcano monitoring incorporates telemetry to handle high-bandwith cameras and broadband seismometers. Critical geophysical targets include the flux of magma in shallow reservoir and lava-tube systems, changes in active hydrothermal systems, volcanic edifice stability, and lahars. Since the eruption of Mount St. Helens in Washington State in 1980, and the eruption at Pu’u O’o in Hawai’i beginning in 1983 and still continuing, dramatic advances have occurred in monitoring technology such as “crisis GIS” and lahar modeling, InSAR interferograms, as well as gas emission geochemistry sampling, and hazards mapping and eruption predictions. The on-going eruption of Mount St. Helens has led to new monitoring technologies, including advances in broadband Wi-Fi and satellite telemetry as well as new instrumentation. Assessment of the gap between adequate monitoring and threat at the 169 potentially dangerous Holocene volcanoes shows where populations are dangerously exposed to volcanic catastrophes in the United States and its territories . This paper focuses primarily on Hawai’ian volcanoes and the northern Pacific and Cascades volcanoes. The US Geological Survey, the US National Park System, and the University of Utah cooperate in a program to monitor the huge Yellowstone volcanic system, and a separate observatory monitors the restive Long Valley caldera in collaboration with the US Forest Service. 

Optical 1's and 2's complement devices using lithium-niobate-based waveguide

NASA Astrophysics Data System (ADS)

Pal, Amrindra; Kumar, Santosh; Sharma, Sandeep

2016-12-01

Optical 1's and 2's complement devices are proposed with the help of lithium-niobate-based Mach-Zehnder interferometers. It has a powerful capability of switching an optical signal from one port to the other port with the help of an electrical control signal. The paper includes the optical conversion scheme using sets of optical switches. 2's complement is common in computer systems and is used in binary subtraction and logical manipulation. The operation of the circuits is studied theoretically and analyzed through numerical simulations. The truth table of these complement methods is verified with the beam propagation method and MATLAB® simulation results.

Broadband reflective liquid crystalline gels due to the ultraviolet light screening made by the liquid crystal

NASA Astrophysics Data System (ADS)

Relaix, Sabrina; Bourgerette, Christian; Mitov, Michel

2006-12-01

It is shown that the natural ultraviolet light absorbing properties of the liquid crystal constituent during the photoinduced elaboration of a liquid crystalline gel induce the broadening of the reflection bandwidth. The polymer component is then included in a resin by preserving its spatial distribution, and transmission electron microscopy investigations of cross sections show the existence of a structure gradient, which is at the origin of the broadening phenomenon. Such reflectors may be of interest for reflective polarizer-free displays or smart windows for the control of solar light for which a broadband reflection is required.

Pushing the Limits of Broadband and High-Frequency Metamaterial Silicon Antireflection Coatings

NASA Astrophysics Data System (ADS)

Coughlin, K. P.; McMahon, J. J.; Crowley, K. T.; Koopman, B. J.; Miller, K. H.; Simon, S. M.; Wollack, E. J.

2018-05-01

Broadband refractive optics realized from high-index materials provide compelling design solutions for the next generation of observatories for the cosmic microwave background and for sub-millimeter astronomy. In this paper, work is presented which extends the state of the art in silicon lenses with metamaterial antireflection coatings toward larger-bandwidth and higher-frequency operation. Examples presented include octave bandwidth coatings with less than 0.5% reflection, a prototype 4:1 bandwidth coating, and a coating optimized for 1.4 THz. For these coatings, the detailed design, fabrication and testing processes are described as well as the inherent performance trade-offs.

Wavelength tunable and broadband variable fiber-optic attenuators using liquid crystals

NASA Astrophysics Data System (ADS)

Khan, Sajjad A.; Riza, Nabeel A.

2005-05-01

Fiber-Optic Variable Optical Attenuators (VOAs) are demonstrated using Liquid Crystals (LC) for broadband as well as wavelength tunable applications. Attenuation is achieved by using a beam spoiling approach implemented via electrically reconfigurable non-pixelated no moving parts Nematic LC deflectors. The VOAs feature in-line architecture and polarization insensitive design without the use of bulky polarization splitting and combining optics. The proof-of-concept VOAs in the 1550 nm band demonstrate >30 dB attenuation ranges, low polarization dependent losses and low power consumption. Applications for these VOAs include agile wavelength tunable secure data communications networks and RF sensor systems.

Latest Trends in Home Networking Technologies

NASA Astrophysics Data System (ADS)

Tsutsui, Akihiro

Broadband access service, including FTTH, is now in widespread use in Japan. More than half of the households that have broadband Internet access construct local area networks (home networks) in their homes. In addition, information appliances such as personal computers, networked audio, and visual devices and game machines are connected to home networks, and many novel service applications are provided via the Internet. However, it is still difficult to install and incorporate these devices and services because networked devices have been developed in different communities. I briefly explain the current status of information appliances and home networking technologies and services and discuss some of the problems in this and their solutions.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jia, X. L.; Meng, Q. X.; Yuan, C. X.

The visible light broadband perfect absorbers based on the silver (Ag) nano elliptical disks and holes array are studied using finite difference time domain simulations. The semiconducting indium silicon dioxide thin film is introduced as the space layer in this sandwiched structure. Utilizing the asymmetrical geometry of the structures, polarization sensitivity for transverse electric wave (TE)/transverse magnetic wave (TM) and left circular polarization wave (LCP)/right circular polarization wave (RCP) of the broadband absorption are gained. The absorbers with Ag nano disks and holes array show several peaks absorbance of 100% by numerical simulation. These simple and flexible perfect absorbers aremore » particularly desirable for various potential applications including the solar energy absorber.« less

A new broadband square law detector. [microwave radiometers

NASA Technical Reports Server (NTRS)

Reid, M. S.; Gardner, R. A.; Stelzried, C. T.

1975-01-01

A broadband constant law detector was developed for precision power measurements, radio metric measurements, and other applications. It has a wide dynamic range and an accurate square law response. Other desirable characteristics, which are all included in a single compact unit, are: (1) high-level dc output with immunity to ground loop problems; (2) fast response times; (3) ability to insert known time constants; and (4) good thermal stability. The detector and its performance are described in detail. The detector can be operated in a programmable system with a ten-fold increase in accuracy. The use and performance of the detector in a noise-adding radiometer system is also discussed.

Nano-optomechanical transducer

DOEpatents

Rakich, Peter T; El-Kady, Ihab F; Olsson, Roy H; Su, Mehmet Fatih; Reinke, Charles; Camacho, Ryan; Wang, Zheng; Davids, Paul

2013-12-03

A nano-optomechanical transducer provides ultrabroadband coherent optomechanical transduction based on Mach-wave emission that uses enhanced photon-phonon coupling efficiencies by low impedance effective phononic medium, both electrostriction and radiation pressure to boost and tailor optomechanical forces, and highly dispersive electromagnetic modes that amplify both electrostriction and radiation pressure. The optomechanical transducer provides a large operating bandwidth and high efficiency while simultaneously having a small size and minimal power consumption, enabling a host of transformative phonon and signal processing capabilities. These capabilities include optomechanical transduction via pulsed phonon emission and up-conversion, broadband stimulated phonon emission and amplification, picosecond pulsed phonon lasers, broadband phononic modulators, and ultrahigh bandwidth true time delay and signal processing technologies.

New insights on the Gibraltar Arc geodynamics from SKS splitting: first contribution from the IberArray broad-band seismic network

NASA Astrophysics Data System (ADS)

Diaz Cusí, Jordi; Gallart, Josep; Villaseñor, Antonio

2010-05-01

The Rif-Betic region, comprising the Gibraltar Arc and the extensional Alboran basin and including the diffuse limit between the Eurasia and African plates, is complex and there is still not a commonly accepted hypothesis about the mechanism responsible for its formation, as models including lithospheric delamination, convective removal or subduction have been proposed. In this context, the knowledge about the presence and properties of upper mantle anisotropy from SKS splitting measurements can provide valuable information to constrain the different geodynamical models. The installation of new permanent and semi-permanent broadband stations in the region has allowed obtaining a first insight into the anisotropic properties (Buontempo et al, 2008) and evidenced the presence of geographical variations in the anisotropic parameters, even if the lack of data in the Northern part of Morocco did not allow to obtain a detailed image. We present here the first analysis of the data provided by the IberArray broad-band seismic network that will allow a significant improvement the coverage of this area. The IberArray broad-band seismic network was deployed over this region for about 18 months, beginning in summer/fall 2007 in the framework of the large-scale Topo-Iberia project. This portable array, formed by up to 55 new generation dataloggers equipped with broad-band seismometers, has covered the southern part of Iberia (35 stations) and northern Morocco (20 stations) in an approximately regular grid, with a nominal spacing of 60 km. Data from more than 35 permanent broadband stations maintained by different institutions operating in the region has also been integrated into the IberArray database. Events with epicentral distances between 85 and 120 degrees and magnitude greater than 6.0 are systematically extracted from the continuous dataset and SKS and SKKS phases are inspected for anisotropy using the SplitLab software. Processing of the whole dataset is still ongoing, but the available results, including those for the entire year 2008, significantly improve the spatial resolution of SKS measurements in this region. The inferred fast velocity directions (FVD) clearly show a spectacular rotation along the Gibraltar arc, following the curvature of the Rif-Betic chain, from roughly N65E beneath the Betics to close to N65W beneath the Rif chain. Stations located in the South and South-east edges of the array, show a distinct pattern, with FVD oriented NE-SW to E-W. The results for some sites suggest the presence of complex anisotropy features, probably including two anisotropic layers. The obtained FVD results are compatible with rollback / subduction models, while convective-removal and delamination models seem unlikely to be compatible with our results. The FVD variations along the Gibraltar arc could be explained by fossil anisotropy acquired during the Eocene Western Mediterranean subduction, while the change in FVD observed to the South and South-East of the Rif-Betic chain can be related to the imprint of a flow episode around the Alboran high velocity slab during its Miocene fragmentation from the Algerian slab.

Chaos-assisted broadband momentum transformation in optical microresonators.

PubMed

Jiang, Xuefeng; Shao, Linbo; Zhang, Shu-Xin; Yi, Xu; Wiersig, Jan; Wang, Li; Gong, Qihuang; Lončar, Marko; Yang, Lan; Xiao, Yun-Feng

2017-10-20

The law of momentum conservation rules out many desired processes in optical microresonators. We report broadband momentum transformations of light in asymmetric whispering gallery microresonators. Assisted by chaotic motions, broadband light can travel between optical modes with different angular momenta within a few picoseconds. Efficient coupling from visible to near-infrared bands is demonstrated between a nanowaveguide and whispering gallery modes with quality factors exceeding 10 million. The broadband momentum transformation enhances the device conversion efficiency of the third-harmonic generation by greater than three orders of magnitude over the conventional evanescent-wave coupling. The observed broadband and fast momentum transformation could promote applications such as multicolor lasers, broadband memories, and multiwavelength optical networks. Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Customer Churn Prediction for Broadband Internet Services

NASA Astrophysics Data System (ADS)

Huang, B. Q.; Kechadi, M.-T.; Buckley, B.

Although churn prediction has been an area of research in the voice branch of telecommunications services, more focused studies on the huge growth area of Broadband Internet services are limited. Therefore, this paper presents a new set of features for broadband Internet customer churn prediction, based on Henley segments, the broadband usage, dial types, the spend of dial-up, line-information, bill and payment information, account information. Then the four prediction techniques (Logistic Regressions, Decision Trees, Multilayer Perceptron Neural Networks and Support Vector Machines) are applied in customer churn, based on the new features. Finally, the evaluation of new features and a comparative analysis of the predictors are made for broadband customer churn prediction. The experimental results show that the new features with these four modelling techniques are efficient for customer churn prediction in the broadband service field.

Atlantic bottlenose dolphin (Tursiops truncatus) hearing threshold for brief broadband signals.

PubMed

Au, Whitlow W L; Lemonds, David W; Vlachos, Stephanie; Nachtigall, Paul E; Roitblat, Herbert L

2002-06-01

The hearing sensitivity of an Atlantic bottlenose dolphin (Tursiops truncatus) to both pure tones and broadband signals simulating echoes from a 7.62-cm water-filled sphere was measured. Pure tones with frequencies between 40 and 140 kHz in increments of 20 kHz were measured along with broadband thresholds using a stimulus with a center frequency of 97.3 kHz and 88.2 kHz. The pure-tone thresholds were compared with the broadband thresholds by converting the pure-tone threshold intensity to energy flux density. The results indicated that dolphins can detect broadband signals slightly better than a pure-tone signal. The broadband results suggest that an echolocating bottlenose dolphin should be able to detect a 7.62-cm diameter water-filled sphere out to a range of 178 m in a quiet environment.

Broadband Liner Optimization for the Source Diagnostic Test Fan

NASA Technical Reports Server (NTRS)

Nark, Douglas M.; Jones, Michael G.

2012-01-01

The broadband component of fan noise has grown in relevance with the utilization of increased bypass ratio and advanced fan designs. Thus, while the attenuation of fan tones remains paramount, the ability to simultaneously reduce broadband fan noise levels has become more appealing. This paper describes a broadband acoustic liner optimization study for the scale model Source Diagnostic Test fan. Specifically, in-duct attenuation predictions with a statistical fan source model are used to obtain optimum impedance spectra over a number of flow conditions for three liner locations in the bypass duct. The predicted optimum impedance information is then used with acoustic liner modeling tools to design liners aimed at producing impedance spectra that most closely match the predicted optimum values. Design selection is based on an acceptance criterion that provides the ability to apply increased weighting to specific frequencies and/or operating conditions. Typical tonal liner designs targeting single frequencies at one operating condition are first produced to provide baseline performance information. These are followed by multiple broadband design approaches culminating in a broadband liner targeting the full range of frequencies and operating conditions. The broadband liner is found to satisfy the optimum impedance objectives much better than the tonal liner designs. In addition, the broadband liner is found to provide better attenuation than the tonal designs over the full range of frequencies and operating conditions considered. Thus, the current study successfully establishes a process for the initial design and evaluation of novel broadband liner concepts for complex engine configurations.

Potential influences of complement factor H in autoimmune inflammatory and thrombotic disorders.

PubMed

Ferluga, Janez; Kouser, Lubna; Murugaiah, Valarmathy; Sim, Robert B; Kishore, Uday

2017-04-01

Complement system homeostasis is important for host self-protection and anti-microbial immune surveillance, and recent research indicates roles in tissue development and remodelling. Complement also appears to have several points of interaction with the blood coagulation system. Deficiency and altered function due to gene mutations and polymorphisms in complement effectors and regulators, including Factor H, have been associated with familial and sporadic autoimmune inflammatory - thrombotic disorders, in which autoantibodies play a part. These include systemic lupus erythematosus, rheumatoid arthritis, atypical haemolytic uremic syndrome, anti-phospholipid syndrome and age-related macular degeneration. Such diseases are generally complex - multigenic and heterogeneous in their symptoms and predisposition/susceptibility. They usually need to be triggered by vascular trauma, drugs or infection and non-complement genetic factors also play a part. Underlying events seem to include decline in peripheral regulatory T cells, dendritic cell, and B cell tolerance, associated with alterations in lymphoid organ microenvironment. Factor H is an abundant protein, synthesised in many cell types, and its reported binding to many different ligands, even if not of high affinity, may influence a large number of molecular interactions, together with the accepted role of Factor H within the complement system. Factor H is involved in mesenchymal stem cell mediated tolerance and also contributes to self-tolerance by augmenting iC3b production and opsonisation of apoptotic cells for their silent dendritic cell engulfment via complement receptor CR3, which mediates anti-inflammatory-tolerogenic effects in the apoptotic cell context. There may be co-operation with other phagocytic receptors, such as complement C1q receptors, and the Tim glycoprotein family, which specifically bind phosphatidylserine expressed on the apoptotic cell surface. Factor H is able to discriminate between self and nonself surfaces for self-protection and anti-microbe defence. Factor H, particularly as an abundant platelet protein, may also modulate blood coagulation, having an anti-thrombotic role. Here, we review a number of interaction pathways in coagulation and in immunity, together with associated diseases, and indicate where Factor H may be expected to exert an influence, based on reports of the diversity of ligands for Factor H. Copyright © 2017 Elsevier Ltd. All rights reserved.

Kupffer cell complement receptor clearance function and host defense.

PubMed

Loegering, D J

1986-01-01

Kupffer cells are well known to be important for normal host defense function. The development of methods to evaluate the in vivo function of specific receptors on Kupffer cells has made it possible to assess the role of these receptors in host defense. The rationale for studying complement receptors is based on the proposed important role of these receptors in host defense and on the observation that the hereditary deficiency of a complement receptor is associated with recurrent severe bacterial infections. The studies reviewed here demonstrate that forms of injury that are associated with depressed host defense including thermal injury, hemorrhagic shock, trauma, and surgery also cause a decrease in complement receptor clearance function. This decrease in Kupffer cell receptor clearance function was shown not to be the result of depressed hepatic blood flow or depletion of complement components. Complement receptor function was also depressed following the phagocytosis of particulates that are known to depress Kupffer cell host defense function. Endotoxemia and bacteremia also were associated with a depression of complement receptor function. Complement receptor function was experimentally depressed in uninjured animals by the phagocytosis of IgG-coated erythrocytes. There was a close association between the depression of complement receptor clearance function and increased susceptibility to the lethal effects of endotoxin and bacterial infection. These studies support the hypotheses that complement receptors on Kupffer cells are important for normal host defense and that depression of the function of these receptors impairs host defense.

47 CFR 27.1214 - EBS spectrum leasing arrangements and grandfathered leases.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and... included in the wireless system of which it is a part. A licensee under this paragraph which enters into a... EBS educational usage onto channels not authorized to it, but which are included in the wireless...

47 CFR 27.1214 - EBS spectrum leasing arrangements and grandfathered leases.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and... included in the wireless system of which it is a part. A licensee under this paragraph which enters into a... EBS educational usage onto channels not authorized to it, but which are included in the wireless...

47 CFR 27.1214 - EBS spectrum leasing arrangements and grandfathered leases.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and... included in the wireless system of which it is a part. A licensee under this paragraph which enters into a... EBS educational usage onto channels not authorized to it, but which are included in the wireless...

75 FR 6627 - Broadband Technology Opportunities Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-10

... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration [Docket No. 0907141137-0079-07] RIN 0660-ZA28 Broadband Technology Opportunities Program AGENCY: National... policy and application procedures for the Broadband Technology Opportunities Program (BTOP) established...

Quiescent complement in nonhuman primates during E coli Shiga toxin-induced hemolytic uremic syndrome and thrombotic microangiopathy.

PubMed

Lee, Benjamin C; Mayer, Chad L; Leibowitz, Caitlin S; Stearns-Kurosawa, D J; Kurosawa, Shinichiro

2013-08-01

Enterohemorrhagic Escherichia coli (EHEC) produce ribosome-inactivating Shiga toxins (Stx1, Stx2) responsible for development of hemolytic uremic syndrome (HUS) and acute kidney injury (AKI). Some patients show complement activation during EHEC infection, raising the possibility of therapeutic targeting of complement for relief. Our juvenile nonhuman primate (Papio baboons) models of endotoxin-free Stx challenge exhibit full spectrum HUS, including thrombocytopenia, hemolytic anemia, and AKI with glomerular thrombotic microangiopathy. There were no significant increases in soluble terminal complement complex (C5b-9) levels after challenge with lethal Stx1 (n = 6) or Stx2 (n = 5) in plasma samples from T0 to euthanasia at 49.5 to 128 hours post-challenge. d-dimer and cell injury markers (HMGB1, histones) confirmed coagulopathy and cell injury. Thus, complement activation is not required for the development of thrombotic microangiopathy and HUS induced by EHEC Shiga toxins in these preclinical models, and benefits or risks of complement inhibition should be studied further for this infection.

Rupture process of a multiple main shock sequence: analysis of teleseismic, local and field observations of the Tennant Creek, Australia, earthquakes of January 22, 1988

USGS Publications Warehouse

Choy, G.L.; Bowman, J.R.

1990-01-01

On January 22, 1988, three large intraplate earthquakes (with MS 6.3, 6.4 and 6.7) occurred within a 12-hour period near Tennant Creek, Australia. Broadband displacement and velocity records of body waves from teleseismically recorded data are analyzed to determine source mechanisms, depths, and complexity of rupture of each of the three main shocks. Hypocenters of an additional 150 foreshocks and aftershocks constrained by local arrival time data and field observations of surface rupture are used to complement the source characteristics of the main shocks. The interpretation of the combined data sets suggests that the overall rupture process involved unusually complicated stress release. Rupture characteristics suggest that substantial slow slip occurred on each of the three fault interfaces that was not accompanied by major energy release. Variation of focal depth and the strong increase of moment and radiated energy with each main shock imply that lateral variations of strength were more important than vertical gradients of shear stress in controlling the progression of rupture. -from Authors

The AlpArray Seismic Network: status and operation

NASA Astrophysics Data System (ADS)

Hetényi, György; Molinari, Irene; Clinton, John; Kissling, Edi

2017-04-01

The AlpArray initiative (http://www.alparray.ethz.ch) is a large-scale European collaboration to study the entire Alpine orogen at high resolution and in 3D with a large variety of geoscientific methods. The core element of the initiative is an extensive and dense broadband seismological network, the AlpArray Seismic Network (AASN). Over 300 temporary stations complement the permanent seismological stations to ensure homogeneous coverage of the greater Alpine area. The AASN has officially started operation in January 2016 and is now complete on land. It is operated in a joint effort by a number of institutions from Austria, Bosnia-Herzegovina, Croatia, Czech Republic, France, Germany, Hungary, Italy, Slovakia and Switzerland. In the Ligurian Sea, a 32-station OBS campaign is planned from June 2017 until March 2018. This will complete the coverage of the greater Alpine area at an unprecedented resolution. In this poster we present the actual status of the deployment, the effort undertaken by the contributing groups, station performance, best practices, data management as well as often encountered challenges, and provide a meeting and discussion point during the conference.

Radio Observations of Elongated Pulsar Wind Nebulae

NASA Astrophysics Data System (ADS)

Ng, Stephen C.-Y.

2015-08-01

The majority of pulsars' rotational energy is carried away by relativistic winds, which are energetic particles accelerated in the magnetosphere. The confinement of the winds by the ambient medium result in synchrotron bubbles with broad-band emission, which are commonly referred to as pulsar wind nebulae (PWNe). Due to long synchrotron cooling time, a radio PWN reflects the integrated history of the system, complementing information obtained from the X-ray and higher energy bands. In addition, radio polarization measurements can offer a powerful probe of the PWN magnetic field structure. Altogether these can reveal the physical conditions and evolutionary history of a system.I report on preliminary results from high-resolution radio observations of PWNe associated with G327.1-1.1, PSRs J1015-5719, B1509-58, and J1549-4848 taken with the Australia Telescope Compact Array (ATCA). Their magnetic field structure and multiwavelength comparison with other observations are discussed.This work is supported by a ECS grant of the Hong Kong Government under HKU 709713P. The Australia Telescope is funded by the Commonwealth of Australia for operation as a National Facility managed by CSIRO.

Quantification of fatigue cracking in CT specimens with passive and active piezoelectric sensing

NASA Astrophysics Data System (ADS)

Yu, Jianguo; Ziehl, Paul; Zarate, Boris; Caicedo, Juan; Yu, Lingyu; Giurgiutiu, Victor; Metrovich, Brian; Matta, Fabio

2010-04-01

Monitoring of fatigue cracks in steel bridges is of interest to bridge owners and agencies. Monitoring of fatigue cracks has been attempted with acoustic emission using either resonant or broadband sensors. One drawback of passive sensing is that the data is limited to that caused by growing cracks. In this work, passive emission was complemented with active sensing (piezoelectric wafer active sensors) for enhanced detection capabilities. Passive and active sensing methods were described for fatigue crack monitoring on specialized compact tension specimens. The characteristics of acoustic emission were obtained to understand the correlation of acoustic emission behavior and crack growth. Crack and noise induced signals were interpreted through Swansong II Filter and waveform-based approaches, which are appropriate for data interpretation of field tests. Upon detection of crack extension, active sensing was activated to measure the crack size. Model updating techniques were employed to minimize the difference between the numerical results and experimental data. The long term objective of this research is to develop an in-service prognostic system to monitor structural health and to assess the remaining fatigue life.

Internet Effects in Times of Political Crisis

PubMed Central

Baccini, Leonardo; Sudulich, Laura; Wall, Matthew

2016-01-01

This paper evaluates the influence of online news consumption on attitudes toward the European Union in a context of protracted economic crisis. Using data from the 2011 Irish National Election Study, we combine location-specific information on broadband availability with respondent geo-location data, which facilitates causal inference about the effects of online news consumption via instrumental variable models. Results show that Irish citizens who source political information online are more prone to blame the EU for the poor state of the economy than those who do not. There is evidence of preference reinforcement among those with negative predispositions toward the EU, but not among pro-EU citizens. We complement this analysis with a study of voting behavior in the European Fiscal Compact Referendum, employing a similar methodological approach. The results from this second survey confirm the anti-EU influence of online news consumption among Irish citizens, although evidence suggests a pro-EU effect among voters who browsed the website of the politically neutral Irish Referendum Commission. Our paper contributes to the literature on public opinion, the EU, and political attitudes in times of crisis. PMID:27274571

75 FR 10464 - Broadband Technology Opportunities Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-08

... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration [Docket Number 0907141137-0119-08] RIN 0660-ZA28 Broadband Technology Opportunities Program AGENCY: National... Infrastructure (CCI) projects under the Broadband Technology Opportunities Program (BTOP) is extended until 5:00...

75 FR 14131 - Broadband Technology Opportunities Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-24

... DEPARTMENT OF COMMERCE National Telecommunications and Information Administration [Docket Number: 0907141137-0154-09] RIN 0660-ZA28 Broadband Technology Opportunities Program AGENCY: National... under the Broadband Technology Opportunities Program (BTOP) is extended until 10 p.m. Eastern Daylight...

A mixed-modem approach to data isolation on a broadband local area network

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crutcher, R.I.; Ewing, P.D.

1988-01-01

Data isolation is required to broadband networks to prevent unauthorized access to the sensitive data of other users. Isolation can be obtained by using equipment from more than one manufacturer to introduce incompatibility between nonassociated users. This paper develops the basis for isolation and postulates that four layers of isolation will exist when the proper equipment is chosen. An experimental broadband local area network (LAN) was constructed to verify isolation. This independent network allowed variations in operating conditions without causing interference in normal broadband operations. The measured results indicate that a broadband LAN can transmit data of varying sensitivity levelsmore » without compromising data security. When combined with certain administrative restrictions, the mixed-modem technique provides a cost-effective method of sharing a broadband network while maintaining isolation of data having different sensitivities. 5 refs., 2 figs.« less

A mixed-modem solution for sensitive data segregation on a broadband network

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crutcher, R.I.; Ewing, P.D.

1988-01-01

Data isolation is required in broadband networks to prevent unauthorized access to the sensitive data of other users. Isolation can be obtained by using equipment from different manufacturers to introduce incompatibility between nonassociated users. This paper develops the basis for isolation and postulates that four layers of ioslation will exist when the proper equipment is chosen. An experimental broadband local area network (LAN) was constructed to verify isolation. This independent test system allowed variations to network operating conditions without causing interference to normal broadband operations. The measured results indicate that a broadband LAN can transmit data of varying sensitivity levelsmore » without compromising data security. When combined with the proper administrative restrictions, the mixed-modem technique provides a cost-effective method of sharing a broadband network while maintaining isolation of data having different sensitivities. 6 refs., 3 figs.« less

A study of rotor broadband noise mechanisms and helicopter tail rotor noise

NASA Technical Reports Server (NTRS)

Chou, Shau-Tak Rudy

1990-01-01

The rotor broadband noise mechanisms considered are the following: (1) lift fluctuation due to turbulence ingestion; (2) boundary layer/trailing edge interaction; (3) tip vortex formation; and (4) turbulent vortex shedding from blunt trailing edge. Predictions show good agreement with available experimental data. The study shows that inflow turbulence is the most important broadband noise source for typical helicopters' main rotors at low- and mid-frequencies. Due to the size difference, isolated helicopter tail rotor broadband noise is not important compared to the much louder main rotor broadband noise. However, the inflow turbulence noise from a tail rotor can be very significant because it is operating in a highly turbulent environment, ingesting wakes from upstream components of the helicopter. The study indicates that the main rotor turbulent wake is the most important source of tail rotor broadband noise. The harmonic noise due to ingestion of main rotor tip vortices is studied.

Compact Infrared Spectrometers

NASA Technical Reports Server (NTRS)

Mouroulis, Pantazis

2009-01-01

Concentric spectrometer forms are advantageous for constructing a variety of systems spanning the entire visible to infrared range. Spectrometer examples are given, including broadband or high resolution forms. Some issues associated with the Dyson catadioptric type are also discussed.

Targeting the complement system for the management of retinal inflammatory and degenerative diseases.

PubMed

Xu, Heping; Chen, Mei

2016-09-15

The retina, an immune privileged tissue, has specialized immune defense mechanisms against noxious insults that may exist in diseases such as age-related macular degeneration (AMD), diabetic retinopathy (DR), uveoretinitis and glaucoma. The defense system consists of retinal innate immune cells (including microglia, perivascular macrophages, and a small population of dendritic cells) and the complement system. Under normal aging conditions, retinal innate immune cells and the complement system undergo a low-grade activation (parainflammation) which is important for retinal homeostasis. In disease states such as AMD and DR, the parainflammatory response is dysregulated and develops into detrimental chronic inflammation. Complement activation in the retina is an important part of chronic inflammation and may contribute to retinal pathology in these disease states. Here, we review the evidence that supports the role of uncontrolled or dysregulated complement activation in various retinal degenerative and angiogenic conditions. We also discuss current strategies that are used to develop complement-based therapies for retinal diseases such as AMD. The potential benefits of complement inhibition in DR, uveoretinitis and glaucoma are also discussed, as well as the need for further research to better understand the mechanisms of complement-mediated retinal damage in these disease states. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

High power broadband millimeter wave TWTs

NASA Astrophysics Data System (ADS)

James, Bill G.

1999-05-01

In the early 1980's the requirement for high power broadband millimeter wave sources encouraged the development of microwave vacuum device amplifiers for radar and communication systems. Many government funded programs were implemented for the development of high power broadband millimeter wave amplifiers that would meet the needs of the high power community. The tube design capable of meeting these goals was the slow wave coupled cavity traveling wave device, which had a proven technology base at the lower frequencies (X Band). However scaling this technology to the millimeter frequencies had severe shortcomings in both thermal and manufacturing design. These shortcomings were overcome with the development of the Ladder Circuit technology. In conjunction with the circuit development high power electron beam systems had to be developed for the generation of high rf powers. These beam systems had to be capable of many megawatts of beam power density and high current densities. The cathode technology required to be capable of operating at current densities of 10 amperes per square centimeter at long pulse lengths and high duty cycle. Since the introduction of the Ladder Circuit technology a number of high power broadband millimeter wave amplifiers have been developed using this technology, and have been deployed in operating radar and communication systems. Broadband millimeter wave sources have been manufactured in the frequency range from 27 GHz to 100 GHz with power levels ranging from 100 watts to 50 kilowatts. Today the power levels achieved by these devices are nearing the limits of this technology; therefore to gain a significant increase in power at the millimeter wave frequencies other technologies will have to be considered particularly fast wave devices. This paper will briefly review the ladder circuit technology and present the designs of a number of broadband high power devices developed at Ka and W band. The discussion will include the beam systems employed in these devices which are the highest power density linear beams generated to date. In conclusion the limits of the power generating capability of this technology will be presented.

High Power Broadband Millimeter Wave TWTs

NASA Astrophysics Data System (ADS)

James, Bill G.

1998-04-01

In the early 1980's the requirement for high power broadband millimeter wave sources encouraged the development of microwave vacuum device amplifiers for radar and communication systems. Many government funded programs were implemented for the development of high power broadband millimeter wave amplifiers that would meet the needs of the high power community. The tube design capable of meeting these goals was the slow wave coupled cavity traveling wave device, which had a proven technology base at the lower frequencies (X Band). However scaling this technology to the millimeter frequencies had severe shortcomings in both thermal and manufacturing design. These shortcomings were overcome with the development of the Ladder Circuit technology. In conjunction with the circuit development high power electron beam systems had to be developed for the generation of high rf powers. These beam systems had to be capable of many megawatts of beam power density and high current densities. The cathode technology required to be capable of operating at current densities of 10 amperes per square centimeter at long pulse lengths and high duty cycle. Since the introduction of the Ladder Circuit technology a number of high power broadband millimeter wave amplifiers have been developed and deployed in operating radar and communication systems. Broadband millimeter wave sources have been manufactured in the frequency range from 27 GHz to 100 GHz with power levels ranging from 100 watts CW to 10 kilowatts Peak at W band over a 2 GHz bandwidth. Also a 50 kW peak power and 10 kW average power device at Ka band with 2 GHz bandwidth has been developed. Today the power levels achieved by these devices are nearing the limits of this technology; therefore to gain a significant increase in power at the millimeter wave frequencies, other technologies will have to be considered, particularly fast wave devices. This paper will briefly review the ladder circuit technology and present the designs of a number of broadband high power devices developed at Ka and W band. The discussion will include the beam systems employed in these devices which are the highest power density linear beams generated to date. In conclusion the limits of the power generating capability of this technology will be presented.

Characteristics of a Broadband Dye Laser Using Pyrromethene and Rhodamine Dyes

NASA Technical Reports Server (NTRS)

Tedder, Sarah A.; Danehy, Paul M.; Wheeler, Jeffrey L.

2011-01-01

A broadband dye laser pumped by a frequency-doubled Nd:YAG laser with a full-width half-maximum (FWHM) from 592 to 610 nm was created for the use in a dual-pump broadband CARS system called WIDECARS. The desired broadband dye laser was generated with a mixture of Pyrromethene dyes as an oscillator gain medium and a spectral selective optic in the oscillator cavity. A mixture of Rhodamine dyes were used in the amplifier dye cell. To create this laser a study was performed to characterize the spectral behavior of broadband dye lasers created with Rhodamine dyes 590, 610, and 640, Pyrromethene dyes 597 and 650 as well as mixture of these dyes.

Evaluation of introduction scenarios for a broadband access network

NASA Astrophysics Data System (ADS)

Bocker, Geert-Jan; Cuthbert, Laurie; Gobbi, Roberta; Inch, Robert; Sara, Lini

1995-02-01

The provision of broadband services at a reasonable cost to residential and small business customers is one of the major challenges facing operators. The introduction of cost-effective systems considering the existing infrastructure is an important study. Within the RACE project 2024 Broadband Access Facilities, the economic and evolution aspects of different introduction scenarios of a broadband access system suitable for providing these services are investigated. This paper presents the final results of this study.

Broadband optical equalizer using fault tolerant digital micromirrors.

PubMed

Riza, Nabeel; Mughal, M Junaid

2003-06-30

For the first time, the design and demonstration of a near continuous spectral processing mode broadband equalizer is described using the earlier proposed macro-pixel spatial approach for multiwavelength fiber-optic attenuation in combination with a high spectral resolution broadband transmissive volume Bragg grating. The demonstrated design features low loss and low polarization dependent loss with broadband operation. Such an analog mode spectral processor can impact optical applications ranging from test and instrumentation to dynamic alloptical networks.

Metropolitan area networks: a corner stone in the broadband era

NASA Astrophysics Data System (ADS)

Ghanem, Adel

1991-02-01

Deployment of Broadband ISDN is being influenced by both a market pull and a technology push. New broadband service opportunities exist in the business and residential sectors of the market place. It is envisioned that some customers will need connections directly to broadband switches because of the high bandwidth needed for their applications. At the same time Metropolitan Area Network (MAN) systems will serve those customers with bandwidth requirements less than or equal to 150 Mbps. A given MAN will have a geographical domain to serve where it will carry out the switching tasks within this domain. While MANs couldbe designed using differentarchitecturalconcepts the setofservices expected tobeprovidedby MANs could be equivalent to thelist ofservices thatwillbe supported by the targetbroadband network. This paperpositions MANs as a major building block for Broadband networks. It also examines the evolution process ofMANs as a needed step to assure the successful deployment of these new broadband services. 2. BISDN - OVERVIEW Broadband ISDN (BISDN) is being driven into existence by both a market pull as well as a technology push. Opportunities for new valueadded services are the prime market pull for future broadband networks. These services opportunities extend beyond simple voice and low speed data applications and cover both the residential and the business sectors of the market. It is noted for instance that business customers have growing needs for sophisticated telecommunication vehicles to support their

Smoke Exposure Causes Endoplasmic Reticulum Stress and Lipid Accumulation in Retinal Pigment Epithelium through Oxidative Stress and Complement Activation*

PubMed Central

Kunchithapautham, Kannan; Atkinson, Carl; Rohrer, Bärbel

2014-01-01

Age-related macular degeneration (AMD) is a complex disease caused by genetic and environmental factors, including genetic variants in complement components and smoking. Smoke exposure leads to oxidative stress, complement activation, endoplasmic reticulum (ER) stress, and lipid dysregulation, which have all been proposed to be associated with AMD pathogenesis. Here we examine the effects of smoke exposure on the retinal pigment epithelium (RPE). Mice were exposed to cigarette smoke or filtered air for 6 months. RPE cells grown as stable monolayers were exposed to 5% cigarette smoke extract (CSE). Effects of smoke were determined by biochemical, molecular, and histological measures. Effects of the alternative pathway (AP) of complement and complement C3a anaphylatoxin receptor signaling were analyzed using knock-out mice or specific inhibitors. ER stress markers were elevated after smoke exposure in RPE of intact mice, which was eliminated in AP-deficient mice. To examine this relationship further, RPE monolayers were exposed to CSE. Short term smoke exposure resulted in production and release of complement C3, the generation of C3a, oxidative stress, complement activation on the cell membrane, and ER stress. Long term exposure to CSE resulted in lipid accumulation, and secretion. All measures were reversed by blocking C3a complement receptor (C3aR), alternative complement pathway signaling, and antioxidant therapy. Taken together, our results provide clear evidence that smoke exposure results in oxidative stress and complement activation via the AP, resulting in ER stress-mediated lipid accumulation, and further suggesting that oxidative stress and complement act synergistically in the pathogenesis of AMD. PMID:24711457

47 CFR 27.1203 - EBS programming requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27... Broadband Service stations are intended primarily through video, data, or voice transmissions to further the... endeavors; (2) Transmission of material directly related to the administrative activities of the licensee...

Broadband Pillbox Antennas.

DTIC Science & Technology

1984-09-21

Identify by block number) - FIELD GROUP SUB-GROUP Double layer pillbox antennas Triple layer pillbox antenna The possibility of designing very broadband... Design .................... 1 Broadband Feed De gn ........................................... 2 Ex mental Simulation of Double Layer Pillbox...5 REFERENCES ................................................... 6 APPENDIX - COAXIAL TO WAVEGUIDE JUNCTION DESIGN

Protective immune responses against West Nile virus are primed by distinct complement activation pathways.

PubMed

Mehlhop, Erin; Diamond, Michael S

2006-05-15

West Nile virus (WNV) causes a severe infection of the central nervous system in several vertebrate animals including humans. Prior studies have shown that complement plays a critical role in controlling WNV infection in complement (C) 3(-/-) and complement receptor 1/2(-/-) mice. Here, we dissect the contributions of the individual complement activation pathways to the protection from WNV disease. Genetic deficiencies in C1q, C4, factor B, or factor D all resulted in increased mortality in mice, suggesting that all activation pathways function together to limit WNV spread. In the absence of alternative pathway complement activation, WNV disseminated into the central nervous system at earlier times and was associated with reduced CD8+ T cell responses yet near normal anti-WNV antibody profiles. Animals lacking the classical and lectin pathways had deficits in both B and T cell responses to WNV. Finally, and somewhat surprisingly, C1q was required for productive infection in the spleen but not for development of adaptive immune responses after WNV infection. Our results suggest that individual pathways of complement activation control WNV infection by priming adaptive immune responses through distinct mechanisms.

Update on hemolytic uremic syndrome: Diagnostic and therapeutic recommendations

PubMed Central

Salvadori, Maurizio; Bertoni, Elisabetta

2013-01-01

Hemolytic uremic syndrome (HUS) is a rare disease. In this work the authors review the recent findings on HUS, considering the different etiologic and pathogenetic classifications. New findings in genetics and, in particular, mutations of genes that encode the complement-regulatory proteins have improved our understanding of atypical HUS. Similarly, the complement proteins are clearly involved in all types of thrombotic microangiopathy: typical HUS, atypical HUS and thrombotic thrombocytopenic purpura (TTP). Furthermore, several secondary HUS appear to be related to abnormalities in complement genes in predisposed patients. The authors highlight the therapeutic aspects of this rare disease, examining both “traditional therapy” (including plasma therapy, kidney and kidney-liver transplantation) and “new therapies”. The latter include anti-Shiga-toxin antibodies and anti-C5 monoclonal antibody “eculizumab”. Eculizumab has been recently launched for the treatment of the atypical HUS, but it appears to be effective in the treatment of typical HUS and in TTP. Future therapies are in phases I and II. They include anti-C5 antibodies, which are more purified, less immunogenic and absorbed orally and, anti-C3 antibodies, which are more powerful, but potentially less safe. Additionally, infusions of recombinant complement-regulatory proteins are a potential future therapy. PMID:24255888

Intercomparison of measurements of NO2 concentrations in the atmosphere simulation chamber SAPHIR during the NO3Comp campaign

NASA Astrophysics Data System (ADS)

Fuchs, H.; Ball, S. M.; Bohn, B.; Brauers, T.; Cohen, R. C.; Dorn, H.-P.; Dubé, W. P.; Fry, J. L.; Häseler, R.; Heitmann, U.; Jones, R. L.; Kleffmann, J.; Mentel, T. F.; Müsgen, P.; Rohrer, F.; Rollins, A. W.; Ruth, A. A.; Kiendler-Scharr, A.; Schlosser, E.; Shillings, A. J. L.; Tillmann, R.; Varma, R. M.; Venables, D. S.; Villena Tapia, G.; Wahner, A.; Wegener, R.; Wooldridge, P. J.; Brown, S. S.

2010-01-01

NO2 concentrations were measured by various instruments during the NO3Comp campaign at the atmosphere simulation chamber SAPHIR at Forschungszentrum Jülich, Germany, in June 2007. Analytical methods included photolytic conversion with chemiluminescence (PC-CLD), broadband cavity ring-down spectroscopy (BBCRDS), pulsed cavity ring-down spectroscopy (CRDS), incoherent broadband cavity-enhanced absorption spectroscopy (IBBCEAS), and laser-induced fluorescence (LIF). All broadband absorption spectrometers were optimized for the detection of the main target species of the campaign, NO3, but were also capable of detecting NO2 simultaneously with reduced sensitivity. NO2 mixing ratios in the chamber were within a range characteristic of polluted, urban conditions, with a maximum mixing ratio of approximately 75 ppbv. The overall agreement between measurements of all instruments was excellent. Linear fits of the combined data sets resulted in slopes that differ from unity only within the stated uncertainty of each instrument. Possible interferences from species such as water vapor and ozone were negligible under the experimental conditions.

Intercomparison of measurements of NO2 concentrations in the atmosphere simulation chamber SAPHIR during the NO3Comp campaign

NASA Astrophysics Data System (ADS)

Fuchs, H.; Ball, S. M.; Bohn, B.; Brauers, T.; Cohen, R. C.; Dorn, H.-P.; Dubé, W. P.; Fry, J. L.; Häseler, R.; Heitmann, U.; Jones, R. L.; Kleffmann, J.; Mentel, T. F.; Müsgen, P.; Rohrer, F.; Rollins, A. W.; Ruth, A. A.; Kiendler-Scharr, A.; Schlosser, E.; Shillings, A. J. L.; Tillmann, R.; Varma, R. M.; Venables, D. S.; Villena Tapia, G.; Wahner, A.; Wegener, R.; Wooldridge, P. J.; Brown, S. S.

2009-10-01

NO2 concentrations were measured by various instruments during the NO3Comp campaign at the atmosphere simulation chamber SAPHIR at Forschungszentrum Jülich, Germany, in June 2007. Analytic methods included photolytic conversion with chemiluminescence (PC-CLD), broadband cavity ring-down spectroscopy (BBCRDS), pulsed cavity ring-down spectroscopy (CRDS), incoherent broadband cavity-enhanced absorption spectroscopy (IBBCEAS), and laser-induced fluorescence (LIF). All broadband absorption spectrometers were optimized for the detection of the main target species of the campaign, NO2, but were also capable of detecting NO2 simultaneously with reduced sensitivity. NO2 mixing ratios in the chamber were within a range characteristic of polluted, urban conditions, with a maximum mixing ratio of approximately 75 ppbv. The overall agreement between measurements of all instruments was excellent. Linear fits of the combined data sets resulted in slopes that differ from unity only within the stated uncertainty of each instrument. Possible interferences from species such as water vapor and ozone were negligible under the experimental conditions.

VizieR Online Data Catalog: z=4.5 and z=5.7 LAEs properties with Spitzer (Finkelstein+, 2015)

NASA Astrophysics Data System (ADS)

Finkelstein, K. D.; Finkelstein, S. L.; Tilvi, V.; Malhotra, S.; Rhoads, J. E.; Grogin, N. A.; Pirzkal, N.; Dey, A.; Jannuzi, B. T.; Mobasher, B.; Pakzad, S.; Salmon, B.; Wang, J.

2017-10-01

The LAEs targeted by the Spitzer survey were discovered by the Large Area Lyman Alpha (LALA) Survey (Rhoads et al. 2000ApJ...545L..85R), which includes the Bootes field and has accompanying deep broadband imaging in B, V, R, I, and z' bands taken with the MOSAIC camera on the 4 m Mayall telescope at the Kitt Peak National Observatory. To select the z=4.5 and 5.7 LAE candidates the following criteria were used: (1) a secure detection (>5σ) in the narrowband filter; (2) a strong narrowband excess, i.e., the flux density in the narrowband should exceed that in the broadband at the 4σ level, this is done by requiring a narrowband-broadband color <-0.75 mag; and (3) no flux at wavelengths shorter than the expected Lyman break. The last condition implies that at z=4.5, sources are undetected in the B-band, while for z=5.7 sources, they are undetected in both the B-band and V-band. (5 data files).

A broadband metamaterial absorber based on multi-layer graphene in the terahertz region

NASA Astrophysics Data System (ADS)

Fu, Pan; Liu, Fei; Ren, Guang Jun; Su, Fei; Li, Dong; Yao, Jian Quan

2018-06-01

A broadband metamaterial absorber, composed of the periodic graphene pattern on SiO2 dielectric with the double layer graphene films inserted in it and all of them backed by metal plan, is proposed and investigated. The simulation results reveal that the wide absorption band can be flexibly tuned between the low-frequency band and the high-frequency band by adjusting graphene's Fermi level. The absorption can achieve 90% in 5.50-7.10 THz, with Fermi level of graphene is 0.3 eV, while in 6.98-9.10 THz with Fermi level 0.6 eV. Furthermore, the proposed structure can be switched from reflection (>81%) to absorption (>90%) over the whole operation band, when the Fermi level of graphene varies from 0 to 0.6 eV. Besides, the proposed absorber is insensitive to the polarization and can work over a wide range of incident angle. Compared with the previous broadband absorber, our graphene based wideband terahertz absorber can enable a wide application of high performance terahertz devices, including sensors, imaging devices and electro-optic switches.

Sound-localization experiments with barn owls in virtual space: influence of broadband interaural level different on head-turning behavior.

PubMed

Poganiatz, I; Wagner, H

2001-04-01

Interaural level differences play an important role for elevational sound localization in barn owls. The changes of this cue with sound location are complex and frequency dependent. We exploited the opportunities offered by the virtual space technique to investigate the behavioral relevance of the overall interaural level difference by fixing this parameter in virtual stimuli to a constant value or introducing additional broadband level differences to normal virtual stimuli. Frequency-specific monaural cues in the stimuli were not manipulated. We observed an influence of the broadband interaural level differences on elevational, but not on azimuthal sound localization. Since results obtained with our manipulations explained only part of the variance in elevational turning angle, we conclude that frequency-specific cues are also important. The behavioral consequences of changes of the overall interaural level difference in a virtual sound depended on the combined interaural time difference contained in the stimulus, indicating an indirect influence of temporal cues on elevational sound localization as well. Thus, elevational sound localization is influenced by a combination of many spatial cues including frequency-dependent and temporal features.

Cylinder and metal grating polarization beam splitter

NASA Astrophysics Data System (ADS)

Yang, Junbo; Xu, Suzhi

2017-08-01

We propose a novel and compact metal grating polarization beam splitter (PBS) based on its different reflected and transmitted orders. The metal grating exhibits a broadband high reflectivity and polarization dependence. The rigorous coupled wave analysis is used to calculate the reflectivity and the transmitting spectra and optimize the structure parameters to realize the broadband PBS. The finite-element method is used to calculate the field distribution. The characteristics of the broadband high reflectivity, transmitting and the polarization dependence are investigated including wavelength, period, refractive index and the radius of circle grating. When grating period d = 400 nm, incident wavelength λ = 441 nm, incident angle θ = 60° and radius of circle d/5, then the zeroth reflection order R0 = 0.35 and the transmission zeroth order T0 = 0.08 for TE polarization, however, T0 = 0.34 and R0 = 0.01 for TM mode. The simple fabrication method involves only single etch step and good compatibility with complementary metal oxide semiconductor technology. PBS designed here is particularly suited for optical communication and optical information processing.

Quantitative imaging of single-shot liquid distributions in sprays using broadband flash x-ray radiography

DOE Office of Scientific and Technical Information (OSTI.GOV)

Halls, B. R.; Roy, S.; Gord, J. R.

Flash x-ray radiography is used to capture quantitative, two-dimensional line-of-sight averaged, single-shot liquid distribution measurements in impinging jet sprays. The accuracy of utilizing broadband x-ray radiation from compact flash tube sources is investigated for a range of conditions by comparing the data with radiographic high-speed measurements from a narrowband, high-intensity synchrotron x-ray facility at the Advanced Photon Source (APS) of Argonne National Laboratory. The path length of the liquid jets is varied to evaluate the effects of energy dependent x-ray attenuation, also known as spectral beam hardening. The spatial liquid distributions from flash x-ray and synchrotron-based radiography are compared, alongmore » with spectral characteristics using Taylor’s hypothesis. The results indicate that quantitative, single-shot imaging of liquid distributions can be achieved using broadband x-ray sources with nanosecond temporal resolution. Practical considerations for optimizing the imaging system performance are discussed, including the coupled effects of x-ray bandwidth, contrast, sensitivity, spatial resolution, temporal resolution, and spectral beam hardening.« less

Sound source localization identification accuracy: Envelope dependencies.

PubMed

Yost, William A

2017-07-01

Sound source localization accuracy as measured in an identification procedure in a front azimuth sound field was studied for click trains, modulated noises, and a modulated tonal carrier. Sound source localization accuracy was determined as a function of the number of clicks in a 64 Hz click train and click rate for a 500 ms duration click train. The clicks were either broadband or high-pass filtered. Sound source localization accuracy was also measured for a single broadband filtered click and compared to a similar broadband filtered, short-duration noise. Sound source localization accuracy was determined as a function of sinusoidal amplitude modulation and the "transposed" process of modulation of filtered noises and a 4 kHz tone. Different rates (16 to 512 Hz) of modulation (including unmodulated conditions) were used. Providing modulation for filtered click stimuli, filtered noises, and the 4 kHz tone had, at most, a very small effect on sound source localization accuracy. These data suggest that amplitude modulation, while providing information about interaural time differences in headphone studies, does not have much influence on sound source localization accuracy in a sound field.

Establishment of a broadband radiometric ground station on the South African east coast

NASA Astrophysics Data System (ADS)

Brooks, Michael J.; Roberts, Lance W.

2009-08-01

A radiometric monitoring program for solar irradiance has been initiated on the Howard College campus of the University of KwaZulu-Natal (UKZN) in Durban, South Africa. This paper describes the establishment of the broadband ground station which employs conventional radiometers and a new type of pyranometer shadow band. The ZEBRA (Zonal Exposure to Broadband RAdiation) band consists of a perforated metal strip that permits the separation of direct normal and diffuse irradiance from global data with a single pyranometer. In this paper a time-based model of the new band's shading mask is described. The model is derived from a ray tracing exercise that accounts for ZEBRA geometry and solar position throughout a generic 365-day year. The UKZN facility lies at 29.9° South latitude and is part of a larger test initiative for the new shadow band that includes the NREL Solar Radiation Research Laboratory in Colorado. Data from northern and southern hemisphere test sites are to be used to characterize performance of the band under a range of conditions and for comparison with output from the newly developed model.

Broadband radiometric LED measurements

NASA Astrophysics Data System (ADS)

Eppeldauer, G. P.; Cooksey, C. C.; Yoon, H. W.; Hanssen, L. M.; Podobedov, V. B.; Vest, R. E.; Arp, U.; Miller, C. C.

2016-09-01

At present, broadband radiometric LED measurements with uniform and low-uncertainty results are not available. Currently, either complicated and expensive spectral radiometric measurements or broadband photometric LED measurements are used. The broadband photometric measurements are based on the CIE standardized V(λ) function, which cannot be used in the UV range and leads to large errors when blue or red LEDs are measured in its wings, where the realization is always poor. Reference irradiance meters with spectrally constant response and high-intensity LED irradiance sources were developed here to implement the previously suggested broadband radiometric LED measurement procedure [1, 2]. Using a detector with spectrally constant response, the broadband radiometric quantities of any LEDs or LED groups can be simply measured with low uncertainty without using any source standard. The spectral flatness of filtered-Si detectors and low-noise pyroelectric radiometers are compared. Examples are given for integrated irradiance measurement of UV and blue LED sources using the here introduced reference (standard) pyroelectric irradiance meters. For validation, the broadband measured integrated irradiance of several LED-365 sources were compared with the spectrally determined integrated irradiance derived from an FEL spectral irradiance lamp-standard. Integrated responsivity transfer from the reference irradiance meter to transfer standard and field UV irradiance meters is discussed.

BREAD: a European coordination action for broadband for all

NASA Astrophysics Data System (ADS)

Van Daele, P.

2006-10-01

The BREAD - co-ordination action, funded by the European Commission through the Framework 6 Programme (FP6) aims at developing a multi-disciplinary approach for the realization of the 'Broadband for All' concept within Europe, bringing together societal, economic, regulatory and technological disciplines and presenting information from regional "success stories" of actual deployment. The EU objective of achieving "Broadband for All" will not be reached by solely a 'technology push' strategy but will need this multi-disciplinary approach and sharing of views and knowledge to develop new strategies and good practice recommendations in the area of 'Broadband for All'. As a co-ordination action the project wants to unite all players active in the field of the end-to-end broadband provisioning for all. It performs a multi-technological analysis of the current and evolving situation, starting from the roadmap information generated by different projects and IST instruments which focus on specific technological domains. The BREAD consortium simultaneously studies the techno-economic, societal and regulatory aspects of this "Broadband for All" concept. It tries to identify the impact of the EU regulatory framework on the successful implementation of new broadband communication services.

Binaural Simulation Experiments in the NASA Langley Structural Acoustics Loads and Transmission Facility

NASA Technical Reports Server (NTRS)

Grosveld, Ferdinand W.; Silcox, Richard (Technical Monitor)

2001-01-01

A location and positioning system was developed and implemented in the anechoic chamber of the Structural Acoustics Loads and Transmission (SALT) facility to accurately determine the coordinates of points in three-dimensional space. Transfer functions were measured between a shaker source at two different panel locations and the vibrational response distributed over the panel surface using a scanning laser vibrometer. The binaural simulation test matrix included test runs for several locations of the measuring microphones, various attitudes of the mannequin, two locations of the shaker excitation and three different shaker inputs including pulse, broadband random, and pseudo-random. Transfer functions, auto spectra, and coherence functions were acquired for the pseudo-random excitation. Time histories were acquired for the pulse and broadband random input to the shaker. The tests were repeated with a reflective surface installed. Binary data files were converted to universal format and archived on compact disk.

The outflow structure of GW170817 from late-time broad-band observations

NASA Astrophysics Data System (ADS)

Troja, E.; Piro, L.; Ryan, G.; van Eerten, H.; Ricci, R.; Wieringa, M. H.; Lotti, S.; Sakamoto, T.; Cenko, S. B.

2018-07-01

We present our broad-band study of GW170817 from radio to hard X-rays, including NuSTAR and Chandra observations up to 165 d after the merger, and a multimessenger analysis including LIGO constraints. The data are compared with predictions from a wide range of models, providing the first detailed comparison between non-trivial cocoon and jet models. Homogeneous and power-law shaped jets, as well as simple cocoon models are ruled out by the data, while both a Gaussian shaped jet and a cocoon with energy injection can describe the current data set for a reasonable range of physical parameters, consistent with the typical values derived from short GRB afterglows. We propose that these models can be unambiguously discriminated by future observations measuring the post-peak behaviour, with Fν ∝ t˜-1.0 for the cocoon and Fν∝ t˜-2.5 for the jet model.

The outflow structure of GW170817 from late time broadband observations

NASA Astrophysics Data System (ADS)

Troja, E.; Piro, L.; Ryan, G.; van Eerten, H.; Ricci, R.; Wieringa, M.; Lotti, S.; Sakamoto, T.; Cenko, S. B.

2018-04-01

We present our broadband study of GW170817 from radio to hard X-rays, including NuSTAR and Chandra observations up to 165 days after the merger, and a multi-messenger analysis including LIGO constraints. The data are compared with predictions from a wide range of models, providing the first detailed comparison between non-trivial cocoon and jet models. Homogeneous and power-law shaped jets, as well as simple cocoon models are ruled out by the data, while both a Gaussian shaped jet and a cocoon with energy injection can describe the current dataset for a reasonable range of physical parameters, consistent with the typical values derived from short GRB afterglows. We propose that these models can be unambiguously discriminated by future observations measuring the post-peak behaviour, with Fν∝t˜-1.0 for the cocoon and Fν∝t˜-2.5 for the jet model.

76 FR 56295 - Schools and Libraries Universal Service Support Mechanism and a National Broadband Plan for Our...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-13

... other individuals on social networking Web sites and in chat rooms, and regarding cyberbullying... appropriate online behavior, including interacting with other individuals on social networking Web sites and... behavior, including interacting with other individuals on social networking Web sites and in chat rooms and...

A novel factor H-Fc chimeric immunotherapeutic molecule against Neisseria gonorrhoeae

PubMed Central

Shaughnessy, Jutamas; Gulati, Sunita; Agarwal, Sarika; Unemo, Magnus; Ohnishi, Makoto; Su, Xia-Hong; Monks, Brian G.; Visintin, Alberto; Madico, Guillermo; Lewis, Lisa A.; Golenbock, Douglas T.; Reed, George W.; Rice, Peter A.; Ram, Sanjay

2015-01-01

Neisseria gonorrhoeae (Ng), the causative agent of the sexually transmitted infection gonorrhea, has developed resistance to almost every conventional antibiotic. There is an urgent need to develop novel therapies against gonorrhea. Many pathogens, including Ng, bind the complement inhibitor factor H (FH) to evade complement-dependent killing. Sialylation of gonococcal lipooligosaccharide, as occurs in vivo, augments binding of human FH through its domains 18-20 (FH18-20). We explored the utility of fusing FH18-20 with IgG Fc (FH18-20/Fc) to create a novel anti-infective immunotherapeutic. FH18-20 also binds to select host glycosaminoglycans to limit unwanted complement activation on host cells. To identify mutation(s) in FH18-20 that eliminated complement activation on host cells, yet maintained binding to Ng, we created four mutations in domains 19 or 20 described in atypical hemolytic uremic syndrome that prevented binding of mutated fH to human erythrocytes. One of the mutant proteins (D to G at position 1119 in domain 19; FHD1119G/Fc) facilitated complement-dependent killing of gonococci similar to unmodified FH18-20/Fc, but unlike FH18-20/Fc, did not lyse human erythrocytes. FHD1119G/Fc bound to all (100%) of 15 sialylated clinical Ng isolates tested (including three contemporary ceftriaxone-resistant strains), mediated complement-dependent killing of 10/15 (67%) strains and enhanced C3 deposition (≥10-fold above baseline levels) on each of the five isolates not directly killed by complement. FHD1119G/Fc facilitated opsonophagocytic killing of a serum-resistant strain by human polymorphonuclear neutrophils. FHD1119G/Fc administered intravaginally significantly reduced the duration and burden of gonococcal infection in the mouse vaginal colonization model. FHD1119G/Fc represents a novel immunotherapeutic against multidrug-resistant Ng. PMID:26773149

Variants in Complement Factor H and Complement Factor H-Related Protein Genes, CFHR3 and CFHR1, Affect Complement Activation in IgA Nephropathy.

PubMed

Zhu, Li; Zhai, Ya-Ling; Wang, Feng-Mei; Hou, Ping; Lv, Ji-Cheng; Xu, Da-Min; Shi, Su-Fang; Liu, Li-Jun; Yu, Feng; Zhao, Ming-Hui; Novak, Jan; Gharavi, Ali G; Zhang, Hong

2015-05-01

Complement activation is common in patients with IgA nephropathy (IgAN) and associated with disease severity. Our recent genome-wide association study of IgAN identified susceptibility loci on 1q32 containing the complement regulatory protein-encoding genes CFH and CFHR1-5, with rs6677604 in CFH as the top single-nucleotide polymorphism and CFHR3-1 deletion (CFHR3-1∆) as the top signal for copy number variation. In this study, to explore the clinical effects of variation in CFH, CFHR3, and CFHR1 on IgAN susceptibility and progression, we enrolled two populations. Group 1 included 1178 subjects with IgAN and available genome-wide association study data. Group 2 included 365 subjects with IgAN and available clinical follow-up data. In group 1, rs6677604 was associated with mesangial C3 deposition by genotype-phenotype correlation analysis. In group 2, we detected a linkage between the rs6677604-A allele and CFHR3-1∆ and found that the rs6677604-A allele was associated with higher serum levels of CFH and lower levels of the complement activation split product C3a. Furthermore, CFH levels were positively associated with circulating C3 levels and negatively associated with mesangial C3 deposition. Moreover, serum levels of the pathogenic galactose-deficient glycoform of IgA1 were also associated with the degree of mesangial C3 deposition in patients with IgAN. Our findings suggest that genetic variants in CFH, CFHR3, and CFHR1 affect complement activation and thereby, predispose patients to develop IgAN. Copyright © 2015 by the American Society of Nephrology.

47 CFR 27.1200 - Change to BRS and EBS.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1200 Change to BRS and EBS... Multichannel Multipoint Distribution Service (MMDS) shall be reassigned to the Broadband Radio Service (BRS...

47 CFR 27.1200 - Change to BRS and EBS.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1200 Change to BRS and EBS... Multichannel Multipoint Distribution Service (MMDS) shall be reassigned to the Broadband Radio Service (BRS...

47 CFR 27.1200 - Change to BRS and EBS.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1200 Change to BRS and EBS... Multichannel Multipoint Distribution Service (MMDS) shall be reassigned to the Broadband Radio Service (BRS...

47 CFR 27.1200 - Change to BRS and EBS.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1200 Change to BRS and EBS... Multichannel Multipoint Distribution Service (MMDS) shall be reassigned to the Broadband Radio Service (BRS...

47 CFR 27.1200 - Change to BRS and EBS.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Broadband Radio Service and Educational Broadband Service § 27.1200 Change to BRS and EBS... Multichannel Multipoint Distribution Service (MMDS) shall be reassigned to the Broadband Radio Service (BRS...

Dielectric Loaded Broadband Gyro-TWT System

DTIC Science & Technology

1993-12-31

A•wov•] f~ •ubic re] ease ;a AD-A277 889 -4 LLV t Final Report 01 Jan 92 - 31 Dec 93 DIELECTRIC LOADED BROADBAND GYRO- TWT SYSTEM Professor N. C...Loaded Broadband Gyro- TWT System" CONTRACT / GRANT NO.: F49620-92-J-O 175 CONTRACT / GRANT VALUE: $89,816 Acce’son For CONTRACT / GRANT PERIOD OF... Broadband Dielectric-Loaded Gyro- TWT Amplifier," submitted for publication to Physics Review Letters, October, 1993. A. Gover, F.V. Hartemann, G.P. Le

Refinements to the Graves and Pitarka (2010) Broadband Ground-Motion Simulation Method

DOE PAGES

Graves, Robert; Pitarka, Arben

2014-12-17

This brief article describes refinements to the Graves and Pitarka (2010) broadband ground-motion simulation methodology (GP2010 hereafter) that have been implemented in version 14.3 of the Southern California Earthquake Center (SCEC) Broadband Platform (BBP). The updated version of our method on the current SCEC BBP is referred to as GP14.3. Here, our simulation technique is a hybrid approach that combines low- and high-frequency motions computed with different methods into a single broadband response.

Mapping photometric metallicities in the Galactic halo using broadband photometry

NASA Astrophysics Data System (ADS)

Hebenstreit, Samuel David; Nidever, David L.; Munn, Jeffrey A.; Majewski, Steven R.

2018-06-01

An important objective of modern Astrophysics is to trace the history of galaxies and the dynamics of their formations. The outer regions of the Milky Way, including the Galactic halo, could potentially elucidate the evolutionary history of our galaxy. In this study, we make use of extensive DDO51 photometry combined with SDSS broadband photometry to select giant stars reaching to 90 kpc. Photometric metallicities, calibrated by overlapping spectroscopic data (SDSS, APOGEE and LAMOST), and distances are calculated for all giant stars. Using these metallicities and distances, we construct metallicity distribution functions (MDFs) from these stars. We study the MDFs for information pertaining to the accretion history of the Milky Way.

UBVRI PHOTOMETRIC STANDARD STARS AROUND THE CELESTIAL EQUATOR: UPDATES AND ADDITIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Landolt, Arlo U.

2009-05-15

New broadband UBVRI photoelectric observations on the Johnson-Kron-Cousins photometric system have been made of 202 stars around the sky, and centered at the celestial equator. These stars constitute both an update of and additions to a previously published list of equatorial photometric standard stars. The list is capable of providing, for both celestial hemispheres, an internally consistent homogeneous broadband standard photometric system around the sky. When these new measurements are included with those previously published by Landolt (1992), the entire list of standard stars in this paper encompasses the magnitude range 8.90 < V < 16.30, and the color indexmore » range -0.35 < (B - V) < +2.30.« less

Broadband parametric amplifiers based on nonlinear kinetic inductance artificial transmission lines

NASA Astrophysics Data System (ADS)

Chaudhuri, S.; Li, D.; Irwin, K. D.; Bockstiegel, C.; Hubmayr, J.; Ullom, J. N.; Vissers, M. R.; Gao, J.

2017-04-01

We present broadband parametric amplifiers based on the kinetic inductance of superconducting NbTiN thin films in an artificial (lumped-element) transmission line architecture. We demonstrate two amplifier designs implementing different phase matching techniques: periodic impedance loading and resonator phase shifters placed periodically along the transmission line. Our design offers several advantages over previous CPW-based amplifiers, including intrinsic 50 Ω characteristic impedance, natural suppression of higher pump harmonics, lower required pump power, and shorter total trace length. Experimental realizations of both versions of the amplifiers are demonstrated. With a transmission line length of 20 cm, we have achieved gains of 15 dB over several GHz of bandwidth.

Group refractive index reconstruction with broadband interferometric confocal microscopy

PubMed Central

Marks, Daniel L.; Schlachter, Simon C.; Zysk, Adam M.; Boppart, Stephen A.

2010-01-01

We propose a novel method of measuring the group refractive index of biological tissues at the micrometer scale. The technique utilizes a broadband confocal microscope embedded into a Mach–Zehnder interferometer, with which spectral interferograms are measured as the sample is translated through the focus of the beam. The method does not require phase unwrapping and is insensitive to vibrations in the sample and reference arms. High measurement stability is achieved because a single spectral interferogram contains all the information necessary to compute the optical path delay of the beam transmitted through the sample. Included are a physical framework defining the forward problem, linear solutions to the inverse problem, and simulated images of biologically relevant phantoms. PMID:18451922

Strong terahertz field generation, detection, and application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Ki-Yong

2016-05-22

This report describes the generation and detection of high-power, broadband terahertz (THz) radiation with using femtosecond terawatt (TW) laser systems. In particular, this focuses on two-color laser mixing in gases as a scalable THz source, addressing both microscopic and macroscopic effects governing its output THz yield and radiation profile. This also includes the characterization of extremely broad THz spectra extending from microwaves to infrared frequencies. Experimentally, my group has generated high-energy (tens of microjoule), intense (>8 MV/cm), and broadband (0.01~60 THz) THz radiation in two-color laser mixing in air. Such an intense THz field can be utilized to study THz-drivenmore » extremely nonlinear phenomena in a university laboratory.« less

Strong terahertz field generation, detection, and application

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Ki-Yong

2016-05-15

This report describes the generation and detection of high-power, broadband terahertz (THz) radiation with using femtosecond terawatt (TW) laser systems. In particular, this focuses on two-color laser mixing in gases as a scalable THz source, addressing both microscopic and macroscopic effects governing its output THz yield and radiation profile. This also includes the characterization of extremely broad THz spectra extending from microwaves to infrared frequencies. Experimentally, my group has generated high-energy (tens of microjoule), intense (>8 MV/cm), and broadband (0.01~60 THz) THz radiation in two-color laser mixing in air. Such an intense THz field can be utilized to study THz-drivenmore » extremely nonlinear phenomena in a university laboratory.« less

Guidelines for Standardized Testing of Broadband Seismometers and Accelerometers

USGS Publications Warehouse

Hutt, Charles R.; Evans, John R.; Followill, Fred; Nigbor, Robert L.; Wielandt, Erhard

2010-01-01

Testing and specification of seismic and earthquake-engineering sensors and recorders has been marked by significant variations in procedures and selected parameters. These variations cause difficulty in comparing such specifications and test results. In July 1989, and again in May 2005, the U.S. Geological Survey hosted international pub-lic/private workshops with the goal of defining widely accepted guidelines for the testing of seismological inertial sensors, seismometers, and accelerometers. The Proceedings of the 2005 workshop have been published and include as appendix 6 the report of the 1989 workshop. This document represents a collation and rationalization of a single set of formal guidelines for testing and specifying broadband seismometers and accelerometers.

A survey of the broadband shock associated noise prediction methods

NASA Technical Reports Server (NTRS)

Kim, Chan M.; Krejsa, Eugene A.; Khavaran, Abbas

1992-01-01

Several different prediction methods to estimate the broadband shock associated noise of a supersonic jet are introduced and compared with experimental data at various test conditions. The nozzle geometries considered for comparison include a convergent and a convergent-divergent nozzle, both axisymmetric. Capabilities and limitations of prediction methods in incorporating the two nozzle geometries, flight effect, and temperature effect are discussed. Predicted noise field shows the best agreement for a convergent nozzle geometry under static conditions. Predicted results for nozzles in flight show larger discrepancies from data and more dependable flight data are required for further comparison. Qualitative effects of jet temperature, as observed in experiment, are reproduced in predicted results.

Complement in Action: An Analysis of Patent Trends from 1976 Through 2011.

PubMed

Yang, Kun; Deangelis, Robert A; Reed, Janet E; Ricklin, Daniel; Lambris, John D

2013-01-01

Complement is an essential part of the innate immune response. It interacts with diverse endogenous pathways and contributes to the maintenance of homeostasis, the modulation of adaptive immune responses, and the development of various pathologies. The potential usefulness, in both research and clinical settings, of compounds that detect or modulate complement activity has resulted in thousands of publications on complement-related innovations in fields such as drug discovery, disease diagnosis and treatment, and immunoassays, among others. This study highlights the distribution and publication trends of patents related to the complement system that were granted by the United States Patent and Trademark Office from 1976 to the present day. A comparison to complement-related documents published by the World Intellectual Property Organization is also included. Statistical analyses revealed increasing diversity in complement-related research interests over time. More than half of the patents were found to focus on the discovery of inhibitors; interest in various inhibitor classes exhibited a remarkable transformation from chemical compounds early on to proteins and antibodies in more recent years. Among clinical applications, complement proteins and their modulators have been extensively patented for the diagnosis and treatment of eye diseases (especially age-related macular degeneration), graft rejection, cancer, sepsis, and a variety of other inflammatory and immune diseases. All of the patents discussed in this chapter, as well as those from other databases, are available from our newly constructed complement patent database: www.innateimmunity.us/patent .

Complement in action: an analysis of patent trends from 1976 through 2011.

PubMed

Yang, Kun; DeAngelis, Robert A; Reed, Janet E; Ricklin, Daniel; Lambris, John D

2013-01-01

Complement is an essential part of the innate immune response. It interacts with diverse endogenous pathways and contributes to the maintenance of homeostasis, the modulation of adaptive immune responses, and the development of various pathologies. The potential usefulness, in both research and clinical settings, of compounds that detect or modulate complement activity has resulted in thousands of publications on complement-related innovations in fields such as drug discovery, disease diagnosis and treatment, and immunoassays, among others. This study highlights the distribution and publication trends of patents related to the complement system that were granted by the United States Patent and Trademark Office from 1976 to the present day. A comparison to complement-related documents published by the World Intellectual Property Organization is also included. Statistical analyses revealed increasing diversity in complement-related research interests over time. More than half of the patents were found to focus on the discovery of inhibitors; interest in various inhibitor classes exhibited a remarkable transformation from chemical compounds early on to proteins and antibodies in more recent years. Among clinical applications, complement proteins and their modulators have been extensively patented for the diagnosis and treatment of eye diseases (especially age-related macular degeneration), graft rejection, cancer, sepsis, and a variety of other inflammatory and immune diseases. All of the patents discussed in this chapter, as well as those from other databases, are available from our newly constructed complement patent database: www.innateimmunity.us/patent.

Molecular mechanisms of inflammation and tissue injury after major trauma-is complement the "bad guy"?

PubMed Central

2011-01-01

Trauma represents the leading cause of death among young people in industrialized countries. Recent clinical and experimental studies have brought increasing evidence for activation of the innate immune system in contributing to the pathogenesis of trauma-induced sequelae and adverse outcome. As the "first line of defense", the complement system represents a potent effector arm of innate immunity, and has been implicated in mediating the early posttraumatic inflammatory response. Despite its generic beneficial functions, including pathogen elimination and immediate response to danger signals, complement activation may exert detrimental effects after trauma, in terms of mounting an "innocent bystander" attack on host tissue. Posttraumatic ischemia/reperfusion injuries represent the classic entity of complement-mediated tissue damage, adding to the "antigenic load" by exacerbation of local and systemic inflammation and release of toxic mediators. These pathophysiological sequelae have been shown to sustain the systemic inflammatory response syndrome after major trauma, and can ultimately contribute to remote organ injury and death. Numerous experimental models have been designed in recent years with the aim of mimicking the inflammatory reaction after trauma and to allow the testing of new pharmacological approaches, including the emergent concept of site-targeted complement inhibition. The present review provides an overview on the current understanding of the cellular and molecular mechanisms of complement activation after major trauma, with an emphasis of emerging therapeutic concepts which may provide the rationale for a "bench-to-bedside" approach in the design of future pharmacological strategies. PMID:22129197

Land ECVs from QA4ECV using an optimal estimation framework

NASA Astrophysics Data System (ADS)

Muller, Jan-Peter; Kharbouche, Said; Lewis, Philip; Danne, Olaf; Blessing, Simon; Giering, Ralf; Gobron, Nadine; Lanconelli, Christian; Govaerts, Yves; Schulz, Joerg; Doutriaux-Boucher, Marie; Lattanzio, Alessio; Aoun, Youva

2017-04-01

In the ESA-DUE GlobAlbedo project (http://www.GlobAlbedo.org), a 15 year record of land surface albedo was generated from the European VEGETATION & MERIS sensors using optimal estimation. This was based on 3 broadbands (0.4-0.7, 0.7-3, 0.4-3µm) and fused data at level-2 after converting from spectral narrowband to these 3 broadbands with surface BRFs. A 10 year long record of land surface albedo climatology was generated from Collection 5 of the MODIS BRDF product for these same broadbands. This was employed as an a priori estimate for an optimal estimation based retrieval of land surface albedo when there were insufficient samples from the European sensors. This so-called MODIS prior was derived at 1km from the 500m MOD43A1,2 BRDF inputs every 8 days using the QA bits and the method described in the GlobAlbedo ATBD which is available from the website (http://www.globalbedo.org/docs/GlobAlbedo_Albedo_ATBD_V4.12.pdf). In the ESA-STSE WACMOS-ET project, FastOpt generated fapar & LAI based on this GlobAlbedo BRDF with associated per pixel uncertainty using the TIP framework. In the successor EU-FP7-QA4ECV* project, we have developed a 33 year record (1981-2014) of Earth surface spectral and broadband albedo (i.e. including the ocean and sea-ice) using optimal estimation for the land and where available, relevant sensors for "instantaneous" retrievals over the poles (Kharbouche & Muller, this conference). This requires the longest possible land surface spectral and broadband BRDF record that can only be supplied by a 16 year of MODIS Collection 6 BRDFs at 500m but produced on a daily basis. The CEMS Big Data computer at RAL was used to generate 7 spectral bands and 3 broadband BRDF with and without snow and snow_only. We will discuss the progress made since the start of the QA4ECV project on the production of a new fused land surface BRDF/albedo spectral and broadband CDR product based on four European sensors: MERIS, (A)ATSR(2), VEGETATION, PROBA-V and two US sensors: MISR & MODIS. For the European sensors, an uniform atmospheric correction scheme has been employed to generate spectral BRF products and these have all been mapped into MODIS spectral bands whilst the US sensors have employed their own level-2 BRF retrieval schemes with associated uncertainty information. Progress is also demonstrated on the use of TIP for fapar/LAI retrieval from the broadband BRDFs as well as fapar from AVHRR based on retrievals from MERIS and OLCI. In parallel, work has taken place at two of our partners on the production of a new geostationary broadband BRF and associated albedo and their fusion with AVHRR-LTDR for a 33 year record. QA4ECV has received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 607405

Broadband athermal waveguides and devices for datacom and telecom applications

NASA Astrophysics Data System (ADS)

He, Liuqing; Guo, Yuhao; Han, Zhaohong; Wada, Kazumi; Kimerling, Lionel C.; Michel, Jurgen; Agarwal, Anuradha M.; Li, Guifang; Zhang, Lin

2018-02-01

The high temperature sensitivity of silicon material limits the applications of silicon-based micro-ring resonators in integrated photonics. To realize a low but broadband temperature-dependence-wavelength-shift (TDWS) micro-ring resonator, designing a broadband athermal waveguide becomes a significant task. In this work, we propose a broadband athermal waveguide which shows a low effective thermos-optical coefficient (TOC) of +/-1×10-6/K at 1400 nm to 1700 nm. The proposed waveguide shows low-loss performance of 0.01 dB/cm and stable broadband-athermal ability when it's applied in micro-ring resonators, and the optical loss of micro-ring resonator with a radius of 100 μm using this waveguide is 0.02 dB/cm.

7 CFR 1738.11 - Availability of broadband service.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Availability of broadband service. 1738.11 Section 1738.11 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL BROADBAND ACCESS LOANS AND LOAN GUARANTEES Loan Purposes and Basic Policies...

Funding Public Computing Centers: Balancing Broadband Availability and Expected Demand

ERIC Educational Resources Information Center

Jayakar, Krishna; Park, Eun-A

2012-01-01

The National Broadband Plan (NBP) recently announced by the Federal Communication Commission visualizes a significantly enhanced commitment to public computing centers (PCCs) as an element of the Commission's plans for promoting broadband availability. In parallel, the National Telecommunications and Information Administration (NTIA) has…

Fan Noise Source Diagnostic Test Computation of Rotor Wake Turbulence Noise

NASA Technical Reports Server (NTRS)

Nallasamy, M.; Envia, E.; Thorp, S. A.; Shabbir, A.

2002-01-01

An important source mechanism of fan broadband noise is the interaction of rotor wake turbulence with the fan outlet guide vanes. A broadband noise model that utilizes computed rotor flow turbulence from a RANS code is used to predict fan broadband noise spectra. The noise model is employed to examine the broadband noise characteristics of the 22-inch Source Diagnostic Test fan rig for which broadband noise data were obtained in wind tunnel tests at the NASA Glenn Research Center. A 9-case matrix of three outlet guide vane configurations at three representative fan tip speeds are considered. For all cases inlet and exhaust acoustic power spectra are computed and compared with the measured spectra where possible. In general, the acoustic power levels and shape of the predicted spectra are in good agreement with the measured data. The predicted spectra show the experimentally observed trends with fan tip speed, vane count, and vane sweep. The results also demonstrate the validity of using CFD-based turbulence information for fan broadband noise calculations.

A Graphical Teaching Tool for Understanding Two's Complement.

ERIC Educational Resources Information Center

Luck, Carlos L.

As part of the Electrical Engineering program at the Univesity of Southern Maine, students are typically introduced to Two's Complement algebra and representation, a method to include negative numbers in the binary representation of integers that is widely used in microprocessors and related digital systems. The traditional, procedural method to…

21 CFR 866.4100 - Complement reagent.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Complement reagent. 866.4100 Section 866.4100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL... naturally occurring serum protein from any warm-blooded animal such as guinea pigs, that may be included as...

21 CFR 866.4100 - Complement reagent.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Complement reagent. 866.4100 Section 866.4100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL... naturally occurring serum protein from any warm-blooded animal such as guinea pigs, that may be included as...

21 CFR 866.4100 - Complement reagent.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Complement reagent. 866.4100 Section 866.4100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL... naturally occurring serum protein from any warm-blooded animal such as guinea pigs, that may be included as...

21 CFR 866.4100 - Complement reagent.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Complement reagent. 866.4100 Section 866.4100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL... naturally occurring serum protein from any warm-blooded animal such as guinea pigs, that may be included as...

Characteristics of broadband slow earthquakes explained by a Brownian model

NASA Astrophysics Data System (ADS)

Ide, S.; Takeo, A.

2017-12-01

Brownian slow earthquake (BSE) model (Ide, 2008; 2010) is a stochastic model for the temporal change of seismic moment release by slow earthquakes, which can be considered as a broadband phenomena including tectonic tremors, low frequency earthquakes, and very low frequency (VLF) earthquakes in the seismological frequency range, and slow slip events in geodetic range. Although the concept of broadband slow earthquake may not have been widely accepted, most of recent observations are consistent with this concept. Then, we review the characteristics of slow earthquakes and how they are explained by BSE model. In BSE model, the characteristic size of slow earthquake source is represented by a random variable, changed by a Gaussian fluctuation added at every time step. The model also includes a time constant, which divides the model behavior into short- and long-time regimes. In nature, the time constant corresponds to the spatial limit of tremor/SSE zone. In the long-time regime, the seismic moment rate is constant, which explains the moment-duration scaling law (Ide et al., 2007). For a shorter duration, the moment rate increases with size, as often observed for VLF earthquakes (Ide et al., 2008). The ratio between seismic energy and seismic moment is constant, as shown in Japan, Cascadia, and Mexico (Maury et al., 2017). The moment rate spectrum has a section of -1 slope, limited by two frequencies corresponding to the above time constant and the time increment of the stochastic process. Such broadband spectra have been observed for slow earthquakes near the trench axis (Kaneko et al., 2017). This spectrum also explains why we can obtain VLF signals by stacking broadband seismograms relative to tremor occurrence (e.g., Takeo et al., 2010; Ide and Yabe, 2014). The fluctuation in BSE model can be non-Gaussian, as far as the variance is finite, as supported by the central limit theorem. Recent observations suggest that tremors and LFEs are spatially characteristic, rather than random (Rubin and Armbruster, 2013; Bostock et al., 2015). Since even spatially characteristic source must be activated randomly in time, moment release from these sources are compatible to the fluctuation in BSE model. Therefore, BSE model contains the model of Gomberg et al. (2016), which suggests that the cluster of LFEs makes VLF signals, as a special case.

Innate Immune Mechanisms in Transplant Allograft Vasculopathy

PubMed Central

Jane-wit, D; Fang, C; Goldstein, DR

2016-01-01

Purpose of Review Allograft vasculopathy (AV) is the leading cause of late allograft loss following solid organ transplantation. Ischemia reperfusion injury (IRI) and donor specific antibody (DSA)-induced complement activation confer heightened risk for AV via numerous innate immune mechanisms including MyD88, HMGB1, and complement induced non-canonical NF-kB signaling. Recent Findings The role of MyD88, a signal adaptor downstream of the toll-like receptors (TLR), has been defined in an experimental heart transplant model, which demonstrated that recipient MyD88 enhanced AV. Importantly, triggering receptor on myeloid receptor 1(Trem1), a MyD88 amplifying signal, was present in rejecting human cardiac transplant biopsies and enhanced the development of AV in mice. HMGB1, a nuclear protein that activates TLRs, also enhanced the development of AV. Complement activation elicits assembly of membrane attack complexes (MAC) on endothelial cells which activate non-canonical NF-kB signaling, a novel complement effector pathway that induces pro-inflammatory genes and potentiates endothelial cell mediated alloimmune T cell activation, processes which enhance AV. Summary Innate immune mediators including HMGB1, MyD88, and non-canonical NFκB signaling via complement activation contribute to AV. These pathways represent potential therapeutic targets to reduce AV after solid organ transplantation. PMID:27077602

Antimicrobial Peptides and Complement in Neonatal Hypoxia-Ischemia Induced Brain Damage

PubMed Central

Rocha-Ferreira, Eridan; Hristova, Mariya

2015-01-01

Hypoxic-ischemic encephalopathy (HIE) is a clinical condition in the neonate, resulting from oxygen deprivation around the time of birth. HIE affects 1–5/1000 live births worldwide and is associated with the development of neurological deficits, including cerebral palsy, epilepsy, and cognitive disabilities. Even though the brain is considered as an immune-privileged site, it has innate and adaptive immune response and can produce complement (C) components and antimicrobial peptides (AMPs). Dysregulation of cerebral expression of AMPs and C can exacerbate or ameliorate the inflammatory response within the brain. Brain ischemia triggers a prolonged inflammatory response affecting the progression of injury and secondary energy failure and involves both innate and adaptive immune systems, including immune-competent and non-competent cells. Following injury to the central nervous system (CNS), including neonatal hypoxia-ischemia (HI), resident microglia, and astroglia are the main cells providing immune defense to the brain in a stimulus-dependent manner. They can express and secrete pro-inflammatory cytokines and therefore trigger prolonged inflammation, resulting in neurodegeneration. Microglial cells express and release a wide range of inflammation-associated molecules including several components of the complement system. Complement activation following neonatal HI injury has been reported to contribute to neurodegeneration. Astrocytes can significantly affect the immune response of the CNS under pathological conditions through production and release of pro-inflammatory cytokines and immunomodulatory AMPs. Astrocytes express β-defensins, which can chemoattract and promote maturation of dendritic cells (DC), and can also limit inflammation by controlling the viability of these same DC. This review will focus on the balance of complement components and AMPs within the CNS following neonatal HI injury and the effect of that balance on the subsequent brain damage. PMID:25729383

Cyclosporine Induces Endothelial Cell Release of Complement-Activating Microparticles

PubMed Central

Renner, Brandon; Klawitter, Jelena; Goldberg, Ryan; McCullough, James W.; Ferreira, Viviana P.; Cooper, James E.; Christians, Uwe

2013-01-01

Defective control of the alternative pathway of complement is an important risk factor for several renal diseases, including atypical hemolytic uremic syndrome. Infections, drugs, pregnancy, and hemodynamic insults can trigger episodes of atypical hemolytic uremic syndrome in susceptible patients. Although the mechanisms linking these clinical events with disease flares are unknown, recent work has revealed that each of these clinical conditions causes cells to release microparticles. We hypothesized that microparticles released from injured endothelial cells promote intrarenal complement activation. Calcineurin inhibitors cause vascular and renal injury and can trigger hemolytic uremic syndrome. Here, we show that endothelial cells exposed to cyclosporine in vitro and in vivo release microparticles that activate the alternative pathway of complement. Cyclosporine-induced microparticles caused injury to bystander endothelial cells and are associated with complement-mediated injury of the kidneys and vasculature in cyclosporine-treated mice. Cyclosporine-induced microparticles did not bind factor H, an alternative pathway regulatory protein present in plasma, explaining their complement-activating phenotype. Finally, we found that in renal transplant patients, the number of endothelial microparticles in plasma increases 2 weeks after starting tacrolimus, and treatment with tacrolimus associated with increased C3 deposition on endothelial microparticles in the plasma of some patients. These results suggest that injury-associated release of endothelial microparticles is an important mechanism by which systemic insults trigger intravascular complement activation and complement-dependent renal diseases. PMID:24092930

Complement activation by carbon nanotubes and its influence on the phagocytosis and cytokine response by macrophages.

PubMed

Pondman, Kirsten M; Sobik, Martin; Nayak, Annapurna; Tsolaki, Anthony G; Jäkel, Anne; Flahaut, Emmanuel; Hampel, Silke; Ten Haken, Bennie; Sim, Robert B; Kishore, Uday

2014-08-01

Carbon nanotubes (CNTs) have promised a range of applications in biomedicine. Although influenced by the dispersants used, CNTs are recognized by the innate immune system, predominantly by the classical pathway of the complement system. Here, we confirm that complement activation by the CNT used continues up to C3 and C5, indicating that the entire complement system is activated including the formation of membrane-attack complexes. Using recombinant forms of the globular regions of human C1q (gC1q) as inhibitors of CNT-mediated classical pathway activation, we show that C1q, the first recognition subcomponent of the classical pathway, binds CNTs via the gC1q domain. Complement opsonisation of CNTs significantly enhances their uptake by U937 cells, with concomitant downregulation of pro-inflammatory cytokines and up-regulation of anti-inflammatory cytokines in both U937 cells and human monocytes. We propose that CNT-mediated complement activation may cause recruitment of cellular infiltration, followed by phagocytosis without inducing a pro-inflammatory immune response. This study highlights the importance of the complement system in response to carbon nanontube administration, suggesting that the ensuing complement activation may cause recruitment of cellular infiltration, followed by phagocytosis without inducing a pro-inflammatory immune response. Copyright © 2014 Elsevier Inc. All rights reserved.

Complement factor H in host defense and immune evasion.

PubMed

Parente, Raffaella; Clark, Simon J; Inforzato, Antonio; Day, Anthony J

2017-05-01

Complement is the major humoral component of the innate immune system. It recognizes pathogen- and damage-associated molecular patterns, and initiates the immune response in coordination with innate and adaptive immunity. When activated, the complement system unleashes powerful cytotoxic and inflammatory mechanisms, and thus its tight control is crucial to prevent damage to host tissues and allow restoration of immune homeostasis. Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations and polymorphisms that affect recognition of self by factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical haemolytic uremic syndrome. In addition, pathogens (i.e., non-self) and cancer cells (i.e., altered-self) can hijack factor H to evade the immune response. Here we review recent (and not so recent) literature on the structure and function of factor H, including the emerging roles of this protein in the pathophysiology of infectious diseases and cancer.

78 FR 14920 - Earth Stations Aboard Aircraft Communicating With Fixed-Satellite Service Geostationary-Orbit...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-08

... broadband services, including Internet access, to passengers and flight crews aboard commercial airliners... available for download over the Internet at http://hraunfoss.fcc.gov/edocs_public/attachmatch/FCC-12-161A1...

75 FR 25185 - Broadband Initiatives Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-07

..., excluding desktop or laptop computers, computer hardware and software (including anti-virus, anti-spyware, and other security software), audio or video equipment, computer network components... 10 desktop or laptop computers and individual workstations to be located within the rural library...

75 FR 28781 - Proposed Information Collection; Comment Request; Broadband Subscription and Usage Supplement to...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-24

... Information Collection; Comment Request; Broadband Subscription and Usage Supplement to the Census Bureau's Current Population Survey AGENCY: National Telecommunications and Information Administration. ACTION... Population Survey (CPS) in order to gather reliable data on broadband (also known as high-speed Internet) use...

75 FR 56057 - Proposed Information Collection; Comment Request; Broadband Technology Opportunities Program Post...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-15

... Information Collection; Comment Request; Broadband Technology Opportunities Program Post-Award Quarterly and... (Recovery Act) establishes and provides $4.7 billion for the Broadband Technology Opportunities Program... million will be made available for competitive grants to expand public computer center capacity; at least...

77 FR 36903 - Accelerating Broadband Infrastructure Deployment

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-20

... coordination with the Chief Performance Officer (CPO). (b) The Working Group shall be composed of: (i) a... broadband infrastructure. Sec. 2. Broadband Deployment on Federal Property Working Group. (a) In order to... Property Working Group (Working Group), to be co-chaired by representatives designated by the Administrator...

47 CFR 1.9047 - Special provisions relating to leases of educational broadband service spectrum.

Code of Federal Regulations, 2014 CFR

2014-10-01

... educational broadband service spectrum. 1.9047 Section 1.9047 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Grants by Random Selection Spectrum Leasing General Policies and Procedures § 1.9047 Special provisions relating to leases of educational broadband service spectrum...

47 CFR 1.9047 - Special provisions relating to leases of educational broadband service spectrum.

Code of Federal Regulations, 2010 CFR

2010-10-01

... educational broadband service spectrum. 1.9047 Section 1.9047 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Spectrum Leasing General Policies and Procedures § 1.9047 Special provisions relating to leases of educational broadband service spectrum. Licensees in the Educational...

47 CFR 1.9047 - Special provisions relating to leases of educational broadband service spectrum.

Code of Federal Regulations, 2011 CFR

2011-10-01

... educational broadband service spectrum. 1.9047 Section 1.9047 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Spectrum Leasing General Policies and Procedures § 1.9047 Special provisions relating to leases of educational broadband service spectrum. Licensees in the Educational...

47 CFR 1.9047 - Special provisions relating to leases of educational broadband service spectrum.

Code of Federal Regulations, 2013 CFR

2013-10-01

... educational broadband service spectrum. 1.9047 Section 1.9047 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Grants by Random Selection Spectrum Leasing General Policies and Procedures § 1.9047 Special provisions relating to leases of educational broadband service spectrum...

47 CFR 1.9047 - Special provisions relating to leases of educational broadband service spectrum.

Code of Federal Regulations, 2012 CFR

2012-10-01

... educational broadband service spectrum. 1.9047 Section 1.9047 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Grants by Random Selection Spectrum Leasing General Policies and Procedures § 1.9047 Special provisions relating to leases of educational broadband service spectrum...

Anti-complementary constituents of Houttuynia cordata and their targets in complement activation cascade.

PubMed

Jiang, Yun; Lu, Yan; Zhang, Yun-Yi; Chen, Dao-Feng

2014-01-01

Activity-guided fractionation for complement inhibitors led to the isolation of 23 known compounds from Houttuynia cordata Thunb. Seven flavonoids, two alkaloids, one coumarin and two phenols showed anti-complementary activity. Preliminary inhibitory mechanism of four flavonoids, including quercitrin, afzelin, isoquercitrin and quercetin in the complement activation cascade were examined for the first time. The results indicated that the target components of flavonols are different from those of flavonosides, and the glycoside moieties may be necessary to block C3 and C4 components.

Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics.

PubMed

Garcia, Brandon L; Skaff, D Andrew; Chatterjee, Arindam; Hanning, Anders; Walker, John K; Wyckoff, Gerald J; Geisbrecht, Brian V

2017-05-01

The complement system is an elegantly regulated biochemical cascade formed by the collective molecular recognition properties and proteolytic activities of more than two dozen membrane-bound or serum proteins. Complement plays diverse roles in human physiology, such as acting as a sentry against invading microorganisms, priming of the adaptive immune response, and removal of immune complexes. However, dysregulation of complement can serve as a trigger for a wide range of human diseases, which include autoimmune, inflammatory, and degenerative conditions. Despite several potential advantages of modulating complement with small-molecule inhibitors, small-molecule drugs are highly underrepresented in the current complement-directed therapeutics pipeline. In this study, we have employed a cheminformatics drug discovery approach based on the extensive structural and functional knowledge available for the central proteolytic fragment of the cascade, C3b. Using parallel in silico screening methodologies, we identified 45 small molecules that putatively bind C3b near ligand-guided functional hot spots. Surface plasmon resonance experiments resulted in the validation of seven dose-dependent C3b-binding compounds. Competition-based biochemical assays demonstrated the ability of several C3b-binding compounds to interfere with binding of the original C3b ligand that guided their discovery. In vitro assays of complement function identified a single complement inhibitory compound, termed cmp-5, and mechanistic studies of the cmp-5 inhibitory mode revealed it acts at the level of C5 activation. This study has led to the identification of a promising new class of C3b-binding small-molecule complement inhibitors and, to our knowledge, provides the first demonstration of cheminformatics-based, complement-directed drug discovery. Copyright © 2017 by The American Association of Immunologists, Inc.

Complement Evasion by Pathogenic Leptospira.

PubMed

Fraga, Tatiana Rodrigues; Isaac, Lourdes; Barbosa, Angela Silva

2016-01-01

Leptospirosis is a neglected infectious disease caused by spirochetes from the genus Leptospira . Pathogenic microorganisms, notably those which reach the blood circulation such as Leptospira , have evolved multiple strategies to escape the host complement system, which is important for innate and acquired immunity. Leptospira avoid complement-mediated killing through: (i) recruitment of host complement regulators; (ii) acquisition of host proteases that cleave complement proteins on the bacterial surface; and, (iii) secretion of proteases that inactivate complement proteins in the Leptospira surroundings. The recruitment of host soluble complement regulatory proteins includes the acquisition of Factor H (FH) and FH-like-1 (alternative pathway), C4b-binding protein (C4BP) (classical and lectin pathways), and vitronectin (Vn) (terminal pathway). Once bound to the leptospiral surface, FH and C4BP retain cofactor activity of Factor I in the cleavage of C3b and C4b, respectively. Vn acquisition by leptospires may result in terminal pathway inhibition by blocking C9 polymerization. The second evasion mechanism lies in plasminogen (PLG) binding to the leptospiral surface. In the presence of host activators, PLG is converted to enzymatically active plasmin, which is able to degrade C3b, C4b, and C5 at the surface of the pathogen. A third strategy used by leptospires to escape from complement system is the active secretion of proteases. Pathogenic, but not saprophytic leptospires, are able to secrete metalloproteases that cleave C3 (central complement molecule), Factor B (alternative pathway), and C4 and C2 (classical and lectin pathways). The purpose of this review is to fully explore these complement evasion mechanisms, which act together to favor Leptospira survival and multiplication in the host.

Complement Evasion by Pathogenic Leptospira

PubMed Central

Fraga, Tatiana Rodrigues; Isaac, Lourdes; Barbosa, Angela Silva

2016-01-01

Leptospirosis is a neglected infectious disease caused by spirochetes from the genus Leptospira. Pathogenic microorganisms, notably those which reach the blood circulation such as Leptospira, have evolved multiple strategies to escape the host complement system, which is important for innate and acquired immunity. Leptospira avoid complement-mediated killing through: (i) recruitment of host complement regulators; (ii) acquisition of host proteases that cleave complement proteins on the bacterial surface; and, (iii) secretion of proteases that inactivate complement proteins in the Leptospira surroundings. The recruitment of host soluble complement regulatory proteins includes the acquisition of Factor H (FH) and FH-like-1 (alternative pathway), C4b-binding protein (C4BP) (classical and lectin pathways), and vitronectin (Vn) (terminal pathway). Once bound to the leptospiral surface, FH and C4BP retain cofactor activity of Factor I in the cleavage of C3b and C4b, respectively. Vn acquisition by leptospires may result in terminal pathway inhibition by blocking C9 polymerization. The second evasion mechanism lies in plasminogen (PLG) binding to the leptospiral surface. In the presence of host activators, PLG is converted to enzymatically active plasmin, which is able to degrade C3b, C4b, and C5 at the surface of the pathogen. A third strategy used by leptospires to escape from complement system is the active secretion of proteases. Pathogenic, but not saprophytic leptospires, are able to secrete metalloproteases that cleave C3 (central complement molecule), Factor B (alternative pathway), and C4 and C2 (classical and lectin pathways). The purpose of this review is to fully explore these complement evasion mechanisms, which act together to favor Leptospira survival and multiplication in the host. PMID:28066433

Temperature-sensitive Mutants of Sindbis Virus: Biochemical Correlates of Complementation

PubMed Central

Burge, Boyce W.; Pfefferkorn, E. R.

1967-01-01

Temperature-sensitive mutants of Sindbis virus fail to grow at a temperature that permits growth of the wild type, but when certain pairs of these mutants, mixed together, infect cells at that temperature, viral growth (i.e., complementation) occurs. The yield from this complementation, however, is of the same order of magnitude as the infectivity in the inoculum. Since in animal virus infections the protein components of the virion probably enter the cell with the viral nucleic acid, it was necessary to demonstrate that the observed complementation required synthesis of new viral protein and nucleic acid rather than some sort of rearrangement of the structural components of the inoculum. To demonstrate that complementation does require new biosynthesis, three biochemical events of normal virus growth have been observed during complementation and correlated with the efficiency of viral growth seen in complementation. These events include: (i) entrance of parental viral ribonucleic acid (RNA) into a double-stranded form; (ii) subsequent synthesis of viral RNA; and (iii) synthesis and subsequent incorporation of viral protein(s) into cell membranes where they were detected by hemadsorption. Although the infecting single-stranded RNA genome of the wild type was converted to a ribonuclease-resistant form, the genome of a mutant (ts-11) incapable of RNA synthesis at a nonpermissive temperature was not so converted. However, during complementation with another mutant also defective in viral RNA synthesis, some of the RNA of mutant ts-11 was converted to a ribonuclease-resistant form, and total synthesis of virus-specific RNA was markedly enhanced. The virus-specific alteration of the cell surface, detected by hemadsorption, was also extensively increased during complementation. These observations support the view that complementation between temperature-sensitive mutants and replication of wild-type virus are similar processes. PMID:5630228

7 CFR 1738.19 - Facilities financed.

Code of Federal Regulations, 2010 CFR

2010-01-01

... broadband loans to finance broadband facilities leased under the terms of a capital lease as defined in... under the terms of an operating lease as defined in generally accepted accounting principles. (c) RUS... applicant. (e) RUS will not make a broadband loan to finance the following items: (1) Customer terminal...

Implementation of a Broadband Cable System on a University Campus.

ERIC Educational Resources Information Center

Rhoadarmer, Michael

1995-01-01

Discusses broadband communications; broadband coaxial cable and its utility in the media center; basic electronics of radio signals (radio frequency, radio band, bandwidth, MHz, skimming, decibels, sloped amplifiers); engineering basics (insertion loss, splitter, tap, and three beats); and factors to consider before designing a campus broadband…

75 FR 33303 - Comment Sought on Measurement of Mobile Broadband Network Performance and Coverage

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-11

...; DA 10-988] Comment Sought on Measurement of Mobile Broadband Network Performance and Coverage AGENCY... broadband services. The Bureau seeks comment on whether and how to pursue a measurement program for mobile... and coverage, and continue to work with measurement companies, application designers, device...

47 CFR 90.18 - Public Safety 700 MHz Nationwide Broadband Network.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Network. 90.18 Section 90.18 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... 700 MHz Nationwide Broadband Network. The 763-768/793-798 MHz band is dedicated to a broadband public..., pursuant to a Network Sharing Agreement and such other agreements as the Commission may require. The...

47 CFR 90.18 - Public Safety 700 MHz Nationwide Broadband Network.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Network. 90.18 Section 90.18 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... 700 MHz Nationwide Broadband Network. The 763-768/793-798 MHz band is dedicated to a broadband public..., pursuant to a Network Sharing Agreement and such other agreements as the Commission may require. The...

Experimental broadband absorption enhancement in silicon nanohole structures with optimized complex unit cells.

PubMed

Lin, Chenxi; Martínez, Luis Javier; Povinelli, Michelle L

2013-09-09

We design silicon membranes with nanohole structures with optimized complex unit cells that maximize broadband absorption. We fabricate the optimized design and measure the optical absorption. We demonstrate an experimental broadband absorption about 3.5 times higher than an equally-thick thin film.

Municipal Broadband in Wilson, North Carolina: A Study

ERIC Educational Resources Information Center

O'Boyle, Timothy

2012-01-01

Relatively little empirical attention has been paid to the political economy of publicly-retailed fiber-optic broadband internet service. To address this gap in the literature, this dissertation examines the history, dynamics and trends in the municipal broadband movement. In specific, Wilson, North Carolina's Greenlight service is examined in…

Broadband Helps Bridge the Achievement Gap

ERIC Educational Resources Information Center

Simmons, Jamal

2013-01-01

In education, technology is giving new meaning to the phrase "equal opportunity." Teachers and students in schools across America--urban, rural, wealthy, and impoverished--are gaining access to online learning and all of its benefits through broadband technology. What is broadband? According to the Federal Communications Commission (FCC), it is…

76 FR 7207 - Notice of Public Information Collection Being Reviewed by the Federal Communications Commission...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-09

... Docket No. 07-52, FCC 10-201, require all providers of broadband Internet access service to publicly... of their broadband Internet access services sufficient for consumers to make informed choices... Network Management Practices, Preserving the Open Internet and Broadband Industry Practices, Report and...

75 FR 48235 - Rural Health Care Universal Service Support Mechanism

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-09

... references to recognized broadband mapping studies, such as NTIA's national broadband map, State or local... network area. In addition to referencing such NTIA or State broadband mapping studies, the applicant would... network design studies (but not in excess of the cap identified below); (2) engineering, materials and...

Security for Telecommuting and Broadband Communications: Recommendations of the National Institute of Standards and Technology

NASA Astrophysics Data System (ADS)

Kuhn, D. R.; Tracy, Miles C.; Frankel, Sheila E.

2002-08-01

This document is intended to assist those responsible - users, system administrators, and management - for telecommuting security, by providing introductory information about broadband communication security and policy, security of home office systems, and considerations for system administrators in the central office. It addresses concepts relating to the selection, deployment, and management of broadband communications for a telecommuting user. This document is not intended to provide a mandatory framework for telecommuting or home office broadband communication environments, but rather to present suggested approaches to the topic.

Broadband infrared beam splitter for spaceborne interferometric infrared sounder.

PubMed

Yu, Tianyan; Liu, Dingquan; Qin, Yang

2014-10-01

A broadband infrared beam splitter (BS) on ZnSe substrate used for the spaceborne interferometric infrared sounder (SIIRS) is studied in the spectral range of 4.44-15 μm. Both broadband antireflection coating and broadband beam-splitter coating in this BS are designed and tested. To optimize the optical properties and the stability of the BS, suitable infrared materials were selected, and improved deposition techniques were applied. The designed structures matched experimental data well, and the properties of the BS met the application specification of SIIRS.

Meta-atom cluster acoustic metamaterial with broadband negative effective mass density

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Huaijun; Zhai, Shilong; Ding, Changlin

2014-02-07

We design a resonant meta-atom cluster, via which a two-dimensional (2D) acoustic metamaterial (AM) with broadband negative effective mass density from 1560 Hz to 5580 Hz is fabricated. Experimental results confirm that there is only weak interaction among the meta-atoms in the cluster. And then the meta-atoms in the cluster independently resonate, resulting in the cluster becoming equivalent to a broadband resonance unit. Extracted effective refractive indices from reflection and transmission measurements of the 2D AM appear to be negative from 1500 Hz to 5480 Hz. The broadband negative refraction has also been demonstrated by our further experiments. We expectmore » that this meta-atom cluster AM will significantly contribute to the design of broadband negative effective mass density AM.« less

Characteristics of a broadband dye laser using Pyrromethene and Rhodamine dyes.

PubMed

Tedder, Sarah A; Wheeler, Jeffrey L; Danehy, Paul M

2011-02-20

A broadband dye laser pumped by a frequency-doubled Nd:YAG laser with a full width at half-maximum from 592 to 610 nm was created for the use in a dual-pump broadband coherent anti-Stokes Raman spectroscopy (CARS) system called width increased dual-pump enhanced CARS (WIDECARS). The desired broadband dye laser was generated with a mixture of Pyrromethene dyes as an oscillator gain medium and a spectral selective optic in the oscillator cavity. A mixture of Rhodamine dyes was used in the amplifier dye cell. To create this laser, a study was performed to characterize the spectral behavior of broadband dye lasers created with Rhodamine dyes 590, 610, and 640 and Pyrromethene dyes 597 and 650, as well as mixtures of these dyes.

Broadband Radiometric LED Measurements

PubMed Central

Eppeldauer, G. P.; Cooksey, C. C.; Yoon, H. W.; Hanssen, L. M.; Podobedov, V. B.; Vest, R. E.; Arp, U.; Miller, C. C.

2017-01-01

At present, broadband radiometric measurements of LEDs with uniform and low-uncertainty results are not available. Currently, either complicated and expensive spectral radiometric measurements or broadband photometric LED measurements are used. The broadband photometric measurements are based on the CIE standardized V(λ) function, which cannot be used in the UV range and leads to large errors when blue or red LEDs are measured in its wings, where the realization is always poor. Reference irradiance meters with spectrally constant response and high-intensity LED irradiance sources were developed here to implement the previously suggested broadband radiometric LED measurement procedure [1, 2]. Using a detector with spectrally constant response, the broadband radiometric quantities of any LEDs or LED groups can be simply measured with low uncertainty without using any source standard. The spectral flatness of filtered-Si detectors and low-noise pyroelectric radiometers are compared. Examples are given for integrated irradiance measurement of UV and blue LED sources using the here introduced reference (standard) pyroelectric irradiance meters. For validation, the broadband measured integrated irradiance of several LED-365 sources were compared with the spectrally determined integrated irradiance derived from an FEL spectral irradiance lamp-standard. Integrated responsivity transfer from the reference irradiance meter to transfer standard and field UV irradiance meters is discussed. PMID:28649167

Broadband Radiometric LED Measurements.

PubMed

Eppeldauer, G P; Cooksey, C C; Yoon, H W; Hanssen, L M; Podobedov, V B; Vest, R E; Arp, U; Miller, C C

2016-01-01

At present, broadband radiometric measurements of LEDs with uniform and low-uncertainty results are not available. Currently, either complicated and expensive spectral radiometric measurements or broadband photometric LED measurements are used. The broadband photometric measurements are based on the CIE standardized V(λ) function, which cannot be used in the UV range and leads to large errors when blue or red LEDs are measured in its wings, where the realization is always poor. Reference irradiance meters with spectrally constant response and high-intensity LED irradiance sources were developed here to implement the previously suggested broadband radiometric LED measurement procedure [1, 2]. Using a detector with spectrally constant response, the broadband radiometric quantities of any LEDs or LED groups can be simply measured with low uncertainty without using any source standard. The spectral flatness of filtered-Si detectors and low-noise pyroelectric radiometers are compared. Examples are given for integrated irradiance measurement of UV and blue LED sources using the here introduced reference (standard) pyroelectric irradiance meters. For validation, the broadband measured integrated irradiance of several LED-365 sources were compared with the spectrally determined integrated irradiance derived from an FEL spectral irradiance lamp-standard. Integrated responsivity transfer from the reference irradiance meter to transfer standard and field UV irradiance meters is discussed.

Unraveling the Structure and Dynamics of the Borborema Province, NE Brazil, With Broadband Seismology

NASA Astrophysics Data System (ADS)

Julià, J.; Bastow, I. D.; Nascimento, R.; Nascimento, A. F.; Rocha, M. P.; Ferreira, J. M.; Fuck, R. A.

2012-04-01

The Borborema Province of NE Brazil comprises the northeasternmost corner of the Brazilian shield and can be regarded as a tectonic collage of basement rocks of Paleoproterozoic age. One of the most intriguing features of the Province concerns its Cenozoic magmatism and uplift. Cenozoic activity is arranged along the north-south trending Macau-Queimadas alignment (MQA) and consists of small-volume, alkaline magmatism with Ar-Ar dates that range between 50 and 7 Ma. The Cenozoic magmatism does not display a clear age progression and is coeval with the uplift of the Borborema Plateau, with average elevations around 400 m and peak altitudes over 1000 m. Recent geochronological studies have shown that small-scale convection at a cratonic edge might provide a plausible explanation for the origin of the Cenozoic magmatism, and gravity surveys have proposed that mafic underplating of the Borboreman crust could be responsible for the uplift. Preliminary seismic results obtained at temporary broadband stations, however, do not support the proposed uplift mechanism. Receiver functions have shown that bulk Vp/Vs ratios increase dramatically from 1.71 to 1.81 across the MQA and that no corresponding increase in crustal thickness is observed. Moreover, velocity-depth profiles from the joint inversion of receiver functions and dispersion velocities reveal that low-velocity zones, rather than mafic underplate, might be present. The seismic observations, nonetheless, are based on just a small number of scattered observations in the Province and tomographic images at lithospheric and sublithospheric depths are lacking. The deep structure of the Province is now being investigated through a temporary seismic experiment funded under the Instituto de Ciência e Tecnologia de Estudos Tectônicos of the National Council for Scientific and Technological Development (CNPq, Brazil). The experiment consists of a backbone seismic network of 20 broadband stations evenly spread throughout the Province complemented by a similar number of short-period stations. The combined network has an aperture of ~400 km in the NE direction, ~600 km in the NS direction, and an average inter-station spacing of ~100 km, and it will be recording continuously for ~2 years. Tomographic images based on fundamental model surface-waves dispersion as well as P- and S-wave travel-times, along with detailed crustal-velocity models, are now being developed under this effort. We expect that the new results, in combination with refined findings for the Borboreman crust, will shed light on the origin of the Cenozoic volcanism and uplift mechanism for the Borborema Province.

Modernization of the Slovenian National Seismic Network

NASA Astrophysics Data System (ADS)

Vidrih, R.; Godec, M.; Gosar, A.; Sincic, P.; Tasic, I.; Zivcic, M.

2003-04-01

The Environmental Agency of the Republic of Slovenia, the Seismology Office is responsible for the fast and reliable information about earthquakes, originating in the area of Slovenia and nearby. In the year 2000 the project Modernization of the Slovenian National Seismic Network started. The purpose of a modernized seismic network is to enable fast and accurate automatic location of earthquakes, to determine earthquake parameters and to collect data of local, regional and global earthquakes. The modernized network will be finished in the year 2004 and will consist of 25 Q730 remote broadband data loggers based seismic station subsystems transmitting in real-time data to the Data Center in Ljubljana, where the Seismology Office is located. The remote broadband station subsystems include 16 surface broadband seismometers CMG-40T, 5 broadband seismometers CMG-40T with strong motion accelerographs EpiSensor, 4 borehole broadband seismometers CMG-40T, all with accurate timing provided by GPS receivers. The seismic network will cover the entire Slovenian territory, involving an area of 20,256 km2. The network is planned in this way; more seismic stations will be around bigger urban centres and in regions with greater vulnerability (NW Slovenia, Krsko Brezice region). By the end of the year 2002, three old seismic stations were modernized and ten new seismic stations were built. All seismic stations transmit data to UNIX-based computers running Antelope system software. The data is transmitted in real time using TCP/IP protocols over the Goverment Wide Area Network . Real-time data is also exchanged with seismic networks in the neighbouring countries, where the data are collected from the seismic stations, close to the Slovenian border. A typical seismic station consists of the seismic shaft with the sensor and the data acquisition system and, the service shaft with communication equipment (modem, router) and power supply with a battery box. which provides energy in case of mains failure. The data acquisition systems are recording continuous time-series sampled at 200 sps, 20 sps and 1sps.

Derivation of Improved Surface and TOA Broadband Fluxes Using CERES-derived Narrowband-to-Broadband Coefficients

NASA Technical Reports Server (NTRS)

Khaiyer, Mandana M.; Doelling, David R.; Chan, Pui K.; Nordeen, MIchele L.; Palikonda, Rabindra; Yi, Yuhong; Minnis, Patrick

2006-01-01

Satellites can provide global coverage of a number of climatically important radiative parameters, including broadband (BB) shortwave (SW) and longwave (LW) fluxes at the top of the atmosphere (TOA) and surface. These parameters can be estimated from narrowband (NB) Geostationary Operational Environmental Satellite (GOES) data, but their accuracy is highly dependent on the validity of the narrowband-to-broadband (NB-BB) conversion formulas that are used to convert the NB fluxes to broadband values. The formula coefficients have historically been derived by regressing matched polarorbiting satellite BB fluxes or radiances with their NB counterparts from GOES (e.g., Minnis et al., 1984). More recently, the coefficients have been based on matched Earth Radiation Budget Experiment (ERBE) and GOES-6 data (Minnis and Smith, 1998). The Clouds and the Earth's Radiant Energy Budget (CERES see Wielicki et al. 1998)) project has recently developed much improved Angular Distribution Models (ADM; Loeb et al., 2003) and has higher resolution data compared to ERBE. A limited set of coefficients was also derived from matched GOES-8 and CERES data taken on Topical Rainfall Measuring Mission (TRMM) satellite (Chakrapani et al., 2003; Doelling et al., 2003). The NB-BB coefficients derived from CERES and the GOES suite should yield more accurate BB fluxes than from ERBE, but are limited spatially and seasonally. With CERES data taken from Terra and Aqua, it is now possible to derive more reliable NB-BB coefficients for any given area. Better TOA fluxes should translate to improved surface radiation fluxes derived using various algorithms. As part of an ongoing effort to provide accurate BB flux estimates for the Atmospheric Radiation Measurement (ARM) Program, this paper documents the derivation of new NB-BB coefficients for the ARM Southern Great Plains (SGP) domain and for the Darwin region of the Tropical Western Pacific (DTWP) domain.

Cloud Macro- and Microphysical Properties Derived from GOES over the ARM SGP Domain

NASA Technical Reports Server (NTRS)

Minnis, P.; Smith, W. L., Jr.; Young, D. F.

2001-01-01

Cloud macrophysical properties like fractional coverage and height Z(sub c) and microphysical parameters such as cloud liquid water path (LWP), effective droplet radius r(sub e), and cloud phase, are key factors affecting both the radiation budget and the hydrological cycle. Satellite data have been used to complement surface observations from Atmospheric Radiation Measurements (ARM) by providing additional spatial coverage and top-of-atmosphere boundary conditions of these key parameters. Since 1994, the Geostationary Operational Environmental Satellite (GOES) has been used for deriving at each half-hour over the ARM Southern Great Plains (SGP) domain: cloud amounts, altitudes, temperatures, and optical depths as well as broadband shortwave (SW) albedo and outgoing longwave radiation at the top of the atmosphere. A new operational algorithm has been implemented to increase the number of value-added products to include cloud particle phase and effective size (r(sub e) or effective ice diameter D(sub e)) as well as LWP and ice water path. Similar analyses have been performed on the data from the Visible Infrared Scanner (VIRS) on the Tropical Rainfall Measuring Mission satellite as part of the Clouds and Earth's Radiant Energy System project. This larger suite of cloud properties will enhance our knowledge of cloud processes and further constrain the mesoscale and single column models using ARM data as a validation/initialization resource. This paper presents the results of applying this new algorithm to GOES-8 data taken during 1998 and 2000. The global VIRS results are compared to the GOES SGP results to provide appropriate context and to test consistency.

Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy (ATOM).

PubMed

Tang, Anson H L; Lai, Queenie T K; Chung, Bob M F; Lee, Kelvin C M; Mok, Aaron T Y; Yip, G K; Shum, Anderson H C; Wong, Kenneth K Y; Tsia, Kevin K

2017-06-28

Scaling the number of measurable parameters, which allows for multidimensional data analysis and thus higher-confidence statistical results, has been the main trend in the advanced development of flow cytometry. Notably, adding high-resolution imaging capabilities allows for the complex morphological analysis of cellular/sub-cellular structures. This is not possible with standard flow cytometers. However, it is valuable for advancing our knowledge of cellular functions and can benefit life science research, clinical diagnostics, and environmental monitoring. Incorporating imaging capabilities into flow cytometry compromises the assay throughput, primarily due to the limitations on speed and sensitivity in the camera technologies. To overcome this speed or throughput challenge facing imaging flow cytometry while preserving the image quality, asymmetric-detection time-stretch optical microscopy (ATOM) has been demonstrated to enable high-contrast, single-cell imaging with sub-cellular resolution, at an imaging throughput as high as 100,000 cells/s. Based on the imaging concept of conventional time-stretch imaging, which relies on all-optical image encoding and retrieval through the use of ultrafast broadband laser pulses, ATOM further advances imaging performance by enhancing the image contrast of unlabeled/unstained cells. This is achieved by accessing the phase-gradient information of the cells, which is spectrally encoded into single-shot broadband pulses. Hence, ATOM is particularly advantageous in high-throughput measurements of single-cell morphology and texture - information indicative of cell types, states, and even functions. Ultimately, this could become a powerful imaging flow cytometry platform for the biophysical phenotyping of cells, complementing the current state-of-the-art biochemical-marker-based cellular assay. This work describes a protocol to establish the key modules of an ATOM system (from optical frontend to data processing and visualization backend), as well as the workflow of imaging flow cytometry based on ATOM, using human cells and micro-algae as the examples.

Source characterization for an explosion during the 2009 eruption of Redoubt Volcano from very-long-period seismic waves

USGS Publications Warehouse

Haney, Matthew M.; Chouet, Bernard A.; Dawson, Phillip B.; Power, John A.

2013-01-01

The 2009 eruption of Redoubt produced several very-long-period (VLP) signals associated with explosions. We invert for the source location and mechanism of an explosion at Redoubt volcano using waveform methods applied to broadband recordings. Such characterization of the source carries information on the geometry of the conduit and the physics of the explosion process. Inversions are carried out assuming the volcanic source can be modeled as a point source, with mechanisms described by a) a set of 3 orthogonal forces, b) a moment tensor consisting of force couples, and c) both forces and moment tensor components. We find that the source of the VLP seismic waves during the explosion is well-described by either a combined moment/force source located northeast of the crater and at an elevation of 1.6 km ASL or a moment source at an elevation of 800 m to the southwest of the crater. The moment tensors for the solutions with moment and force and moment-only share similar characteristics. The source time functions for both moment tensors begin with inflation (pressurization) and execute two cycles of deflation-reinflation (depressurization–repressurization). Although the moment/force source provides a better fit to the data, we find that owing to the limited coverage of the broadband stations at Redoubt the moment-only source is the more robust and reliable solution. Based on the moment-only solution, we estimate a volume change of 19,000 m3 and a pressure change of 7 MPa in a dominant sill and an out-of-phase volume change of 5000 m3 and pressure change of 1.8 MPa in a subdominant dike at the source location. These results shed new light on the magmatic plumbing system beneath Redoubt and complement previous studies on Vulcanian explosions at other volcanoes.

Dual-cone double-helical downhole logging device

DOEpatents

Yu, Jiunn S.

1984-01-01

A broadband downhole logging device includes a double-helix coil wrapped over a dielectric support and surrounded by a dielectric shield. The device may also include a second coil longitudinally aligned with a first coil and enclosed within the same shield for measuring magnetic permeability of downhole formations and six additional coils for accurately determining downhole parameters.

77 FR 51048 - United States et al. v. Verizon Communications Inc. et al.; Proposed Final Judgment and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-23

... offerings for their customers who want a bundle including such services. Although the agreements permit the... retail outlets selling two competing quad-play offerings: one including Verizon Wireless services and a..., video, and broadband FiOS services, and over 90% of FiOS customers subscribe to some form of bundle...

Air Force and Army Corps of Engineers Improperly Managed the Award of Contracts for the Blue Devil Block 2 Persistent Surveillance System

DTIC Science & Technology

2013-09-19

environments. This can include the development of new and/or improved analytical and numerical models, rapid data-processing techniques, and new subsurface ... imaging techniques that include active and passive sensor modalities in a variety of rural and urban terrains. Of particular interest is the broadband

Complement Activation: An Emerging Player in the Pathogenesis of Cardiovascular Disease

PubMed Central

Carter, Angela M.

2012-01-01

A wealth of evidence indicates a fundamental role for inflammation in the pathogenesis of cardiovascular disease (CVD), contributing to the development and progression of atherosclerotic lesion formation, plaque rupture, and thrombosis. An increasing body of evidence supports a functional role for complement activation in the pathogenesis of CVD through pleiotropic effects on endothelial and haematopoietic cell function and haemostasis. Prospective and case control studies have reported strong relationships between several complement components and cardiovascular outcomes, and in vitro studies and animal models support a functional effect. Complement activation, in particular, generation of C5a and C5b-9, influences many processes involved in the development and progression of atherosclerosis, including promotion of endothelial cell activation, leukocyte infiltration into the extracellular matrix, stimulation of cytokine release from vascular smooth muscle cells, and promotion of plaque rupture. Complement activation also influences thrombosis, involving components of the mannose-binding lectin pathway, and C5b-9 in particular, through activation of platelets, promotion of fibrin formation, and impairment of fibrinolysis. The participation of the complement system in inflammation and thrombosis is consistent with the physiological role of the complement system as a rapid effector system conferring protection following vessel injury. However, in the context of CVD, these same processes contribute to development of atherosclerosis, plaque rupture, and thrombosis. PMID:24278688

Campus Nets for the Nineties.

ERIC Educational Resources Information Center

Neff, Raymond K.

1994-01-01

Describes present and future plans for the campuswide communications network at Case Western Reserve University (Ohio). Highlights include upgrading from baseband to broadband technologies; ATM (Asynchronous Transfer Mode)-based networks that allow simultaneous voice, video, and data transmission; strategic planning goals; implications for…

Digital Collections, Digital Libraries & the Digitization of Cultural Heritage Information.

ERIC Educational Resources Information Center

Lynch, Clifford

2002-01-01

Discusses digital collections and digital libraries. Topics include broadband availability; digital rights protection; content, both non-profit and commercial; digitization of cultural content; sustainability; metadata harvesting protocol; infrastructure; authorship; linking multiple resources; data mining; digitization of reference works;…

Relations between Mental Verb and False Belief Understanding in Cantonese-Speaking Children

ERIC Educational Resources Information Center

Cheung, Him; Chen, Hsuan-Chih; Yeung, William

2009-01-01

Previous research has shown that linguistic forms that codify mental contents bear a specific relation with children's false belief understanding. These forms include mental verbs and their following complements, yet the two have not been considered separately. The current study examined the roles of mental verb semantics and the complement syntax…

The Lectin Pathway of Complement and Rheumatic Heart Disease

PubMed Central

Beltrame, Marcia Holsbach; Catarino, Sandra Jeremias; Goeldner, Isabela; Boldt, Angelica Beate Winter; de Messias-Reason, Iara José

2014-01-01

The innate immune system is the first line of host defense against infection and is comprised of humoral and cellular mechanisms that recognize potential pathogens within minutes or hours of entry. The effector components of innate immunity include epithelial barriers, phagocytes, and natural killer cells, as well as cytokines and the complement system. Complement plays an important role in the immediate response against microorganisms, including Streptococcus sp. The lectin pathway is one of three pathways by which the complement system can be activated. This pathway is initiated by the binding of mannose-binding lectin (MBL), collectin 11 (CL-K1), and ficolins (Ficolin-1, Ficolin-2, and Ficolin-3) to microbial surface oligosaccharides and acetylated residues, respectively. Upon binding to target molecules, MBL, CL-K1, and ficolins form complexes with MBL-associated serine proteases 1 and 2 (MASP-1 and MASP-2), which cleave C4 and C2 forming the C3 convertase (C4b2a). Subsequent activation of complement cascade leads to opsonization, phagocytosis, and lysis of target microorganisms through the formation of the membrane-attack complex. In addition, activation of complement may induce several inflammatory effects, such as expression of adhesion molecules, chemotaxis and activation of leukocytes, release of reactive oxygen species, and secretion of cytokines and chemokines. In this chapter, we review the general aspects of the structure, function, and genetic polymorphism of lectin-pathway components and discuss most recent understanding on the role of the lectin pathway in the predisposition and clinical progression of Rheumatic Fever. PMID:25654073

77 FR 30423 - Innovation in the Broadcast Television Bands: Allocations, Channel Sharing and Improvements to...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-23

... uses. This action serves to further address the nation's growing demand for wireless broadband services... keeps pace with the global wireless revolution. At the same time, the approach helps preserve broadcast... National Broadband Plan to repurpose spectrum from the U/V bands for new wireless broadband uses through...

Silicon graphene waveguide tunable broadband microwave photonics phase shifter.

PubMed

Capmany, José; Domenech, David; Muñoz, Pascual

2014-04-07

We propose the use of silicon graphene waveguides to implement a tunable broadband microwave photonics phase shifter based on integrated ring cavities. Numerical computation results show the feasibility for broadband operation over 40 GHz bandwidth and full 360° radiofrequency phase-shift with a modest voltage excursion of 0.12 volt.

First Time Facilitator's Experience: Designing and Facilitating an Action Learning Programme in China

ERIC Educational Resources Information Center

Wang, Jinshuai; Bloodworth, Mike

2016-01-01

This paper describes an action learning programme with China Unicom Broadband Limited (CUBO) to support its vision of transforming to become a world-leading broadband communications and information service provider. 64 Department directors and supervisors were invited to take part in the "China Unicom Broadband Online Phoenix Action Learning…

77 FR 3635 - Connect America Fund; A National Broadband Plan for Our Future; Establishing Just and Reasonable...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-25

...-208; Report No. 2945] Connect America Fund; A National Broadband Plan for Our Future; Establishing Just and Reasonable Rates for Local Exchange Carriers; High-Cost Universal Service Support et al... applicability. Subject: Connect America Fund: A National Broadband Plan for Our Future; Establishing Just and...

Recovery Act Investments in Broadband: Leveraging Federal Dollars to Create Jobs and Connect America

ERIC Educational Resources Information Center

Executive Office of the President, 2009

2009-01-01

Broadband touches nearly every aspect of the U.S. economy, providing Americans with unprecedented opportunities in employment, education, health care, entrepreneurship, and civic participation. For millions of Americans without adequate access to broadband, however, the possibility of falling behind in the knowledge-based economy is real.…

76 FR 37779 - Rural Broadband Access Loans and Loan Guarantees Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-28

... DEPARTMENT OF AGRICULTURE Rural Utilities Service Rural Broadband Access Loans and Loan Guarantees... of $325,663,157 in loan funds for the Rural Broadband Access Loans and Loan Guarantees Program for... identifying a definite funding amount. The maximum amount of a loan under this authority will be $75 million...

Not all carp are created equal: Impacts of broadband sound on common carp swimming behavior

USGS Publications Warehouse

Murchy, Kelsie; Vetter, Brooke J.; Brey, Marybeth; Amberg, Jon J.; Gaikowski, Mark; Mensinger, Allen F.

2016-01-01

Bighead carp (Hypophthalmichthys nobilis), silver carp (H. molitrix) (hereafter: bigheaded carps), and common carp (Cyprinus carpio) are invasive fish causing negative impacts throughout their North American range. To control their movements, non-physical barriers are being developed. Broadband sound (0.06 to 10 kHz) has shown potential as an acoustic deterrent for bigheaded carps, but the response of common carp to broadband sound has not been evaluated. Since common carp are ostariophysians, possessing Weberian ossicles similar to bigheaded carps, it is possible that sound can be used as an acoustical deterrent for all three species. Behavioral responses to a broadband sound were evaluated for common carp in an outdoor concrete pond. Common carp responded a median of 3.0 (1st Q: 1.0, 3rd Q: 6.0) consecutive times to the broadband sound which was lower than silver carp and bighead carp to the same stimulus. The current study shows that common carp demonstrate an inconsistent negative phonotaxis response to a broadband sound, and seem to habituate to the sound quickly.

The Prediction of Scattered Broadband Shock-Associated Noise

NASA Technical Reports Server (NTRS)

Miller, Steven A. E.

2015-01-01

A mathematical model is developed for the prediction of scattered broadband shock-associated noise. Model arguments are dependent on the vector Green's function of the linearized Euler equations, steady Reynolds-averaged Navier-Stokes solutions, and the two-point cross-correlation of the equivalent source. The equivalent source is dependent on steady Reynolds-averaged Navier-Stokes solutions of the jet flow, that capture the nozzle geometry and airframe surface. Contours of the time-averaged streamwise velocity component and turbulent kinetic energy are examined with varying airframe position relative to the nozzle exit. Propagation effects are incorporated by approximating the vector Green's function of the linearized Euler equations. This approximation involves the use of ray theory and an assumption that broadband shock-associated noise is relatively unaffected by the refraction of the jet shear layer. A non-dimensional parameter is proposed that quantifies the changes of the broadband shock-associated noise source with varying jet operating condition and airframe position. Scattered broadband shock-associated noise possesses a second set of broadband lobes that are due to the effect of scattering. Presented predictions demonstrate relatively good agreement compared to a wide variety of measurements.

Broadband and efficient plasmonic control in the near-infrared and visible via strong interference of surface plasmon polaritons.

PubMed

Gan, C H; Nash, G R

2013-11-01

Broadband and tunable control of surface plasmon polaritons in the near-infrared and visible spectrum is demonstrated theoretically and numerically with a pair of phased nanoslits. We establish, with simulations supported by a coupled wave model, that by dividing the incident power equally between two input channels, the maximum plasmon intensity deliverable to either side of the nanoslit pair is twice that for an isolated slit. For a broadband source, a compact device with nanoslit separation of the order of a tenth of the wavelength is shown to steer nearly all the generated plasmons to one side for the same phase delay, thereby achieving a broadband unidirectional plasmon launcher. The reported effect can be applied to the design of ultra-broadband and efficient tunable plasmonic devices.

Neural networks using broadband spectral discriminators reduces illumination required for broccoli identification in weedy fields

NASA Astrophysics Data System (ADS)

Hahn, Federico

1996-03-01

Statistical discriminative analysis and neural networks were used to prove that crop/weed/soil discrimination by optical reflectance was feasible. The wavelengths selected as inputs on those neural networks were ten nanometers width, reducing the total collected radiation for the sensor. Spectral data collected from several farms having different weed populations were introduced to discriminant analysis. The best discriminant wavelengths were used to build a wavelength histogram which selected the three best spectral broadbands for broccoli/weed/soil discrimination. The broadbands were analyzed using a new single broadband discriminator index named the discriminative integration index, DII, and the DII values obtained were used to train a neural network. This paper introduces the index concept, its results and its use for minimizing artificial lightning requirements with broadband spectral measurements for broccoli/weed/soil discrimination.

Control of broadband optically generated ultrasound pulses using binary amplitude holograms.

PubMed

Brown, Michael D; Jaros, Jiri; Cox, Ben T; Treeby, Bradley E

2016-04-01

In this work, the use of binary amplitude holography is investigated as a mechanism to focus broadband acoustic pulses generated by high peak-power pulsed lasers. Two algorithms are described for the calculation of the binary holograms; one using ray-tracing, and one using an optimization based on direct binary search. It is shown using numerical simulations that when a binary amplitude hologram is excited by a train of laser pulses at its design frequency, the acoustic field can be focused at a pre-determined distribution of points, including single and multiple focal points, and line and square foci. The numerical results are validated by acoustic field measurements from binary amplitude holograms, excited by a high peak-power laser.

Multilayer optical dielectric coating

DOEpatents

Emmett, John L.

1990-01-01

A highly damage resistant, multilayer, optical reflective coating includes alternating layers of doped and undoped dielectric material. The doping levels are low enough that there are no distinct interfaces between the doped and undoped layers so that the coating has properties nearly identical to the undoped material. The coating is fabricated at high temperature with plasma-assisted chemical vapor deposition techniques to eliminate defects, reduce energy-absorption sites, and maintain proper chemical stoichiometry. A number of differently-doped layer pairs, each layer having a thickness equal to one-quarter of a predetermined wavelength in the material are combined to form a narrowband reflective coating for a predetermined wavelength. Broadband reflectors are made by using a number of narrowband reflectors, each covering a portion of the broadband.

Broadband parametric amplifiers based on nonlinear kinetic inductance artificial transmission lines

DOE PAGES

Chaudhuri, S.; Li, D.; Irwin, K. D.; ...

2017-04-10

Here, we present broadband parametric amplifiers based on the kinetic inductance of superconducting NbTiN thin films in an artificial (lumped-element) transmission line architecture. We demonstrate two amplifier designs implementing different phase matching techniques: periodic impedance loading and resonator phase shifters placed periodically along the transmission line. Our design offers several advantages over previous CPW-based amplifiers, including intrinsic 50 Ω characteristic impedance, natural suppression of higher pump harmonics, lower required pump power, and shorter total trace length. Experimental realizations of both versions of the amplifiers are demonstrated. In conclusion, with a transmission line length of 20 cm, we have achieved gainsmore » of 15 dB over several GHz of bandwidth.« less

Broadband parametric amplifiers based on nonlinear kinetic inductance artificial transmission lines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chaudhuri, S.; Li, D.; Irwin, K. D.

Here, we present broadband parametric amplifiers based on the kinetic inductance of superconducting NbTiN thin films in an artificial (lumped-element) transmission line architecture. We demonstrate two amplifier designs implementing different phase matching techniques: periodic impedance loading and resonator phase shifters placed periodically along the transmission line. Our design offers several advantages over previous CPW-based amplifiers, including intrinsic 50 Ω characteristic impedance, natural suppression of higher pump harmonics, lower required pump power, and shorter total trace length. Experimental realizations of both versions of the amplifiers are demonstrated. In conclusion, with a transmission line length of 20 cm, we have achieved gainsmore » of 15 dB over several GHz of bandwidth.« less

New Broadband LIDAR for Greenhouse Carbon Dioxide Gas Sensing in the Earth's Atmosphere

NASA Technical Reports Server (NTRS)

Georgieva, Elena; Heaps, William S.; Huang,Wen

2011-01-01

We present demonstration of a novel broadband lidar technique capable of dealing with the atmospherically induced variations in CO2 absorption using a Fabry-Perot based detector and a broadband laser. The Fabry-Perot solid etalon in the receiver part is tuned to match the wavelength of several CO2 absorption lines simultaneously. The broadband technique tremendously reduces the requirement for source wavelength stability, instead putting this responsibility on the Fabry- Perot based receiver. The instrument technology we are developing has a clear pathway to space and realistic potential to become a robust, low risk space measurement system.

UHB Engine Fan Broadband Noise Reduction Study

NASA Technical Reports Server (NTRS)

Gliebe, Philip R.; Ho, Patrick Y.; Mani, Ramani

1995-01-01

A study has been completed to quantify the contribution of fan broadband noise to advanced high bypass turbofan engine system noise levels. The result suggests that reducing fan broadband noise can produce 3 to 4 EPNdB in engine system noise reduction, once the fan tones are eliminated. Further, in conjunction with the elimination of fan tones and an increase in bypass ratio, a potential reduction of 7 to 10 EPNdB in system noise can be achieved. In addition, an initial assessment of engine broadband noise source mechanisms has been made, concluding that the dominant source of fan broadband noise is the interaction of incident inlet boundary layer turbulence with the fan rotor. This source has two contributors, i.e., unsteady life dipole response and steady loading quadrupole response. The quadrupole contribution was found to be the most important component, suggesting that broadband noise reduction can be achieved by the reduction of steady loading field-turbulence field quadrupole interaction. Finally, for a controlled experimental quantification and verification, the study recommends that further broadband noise tests be done on a simulated engine rig, such as the GE Aircraft Engine Universal Propulsion Simulator, rather than testing on an engine statically in an outdoor arena The rig should be capable of generating forward and aft propagating fan noise, and it needs to be tested in a large freejet or a wind tunnel.

Pyrolysis of Helical Coordination Polymers for Metal-Sulfide-Based Helices with Broadband Chiroptical Activity.

PubMed

Hirai, Kenji; Yeom, Bongjun; Sada, Kazuki

2017-06-27

Fabrication of chiroptical materials with broadband response in the visible light region is vital to fully realize their potential applications. One way to achieve broadband chiroptical activity is to fabricate chiral nanostructures from materials that exhibit broadband absorption in the visible light region. However, the compounds used for chiroptical materials have predominantly been limited to materials with narrowband spectral response. Here, we synthesize Ag 2 S-based nanohelices derived from helical coordination polymers. The right- and left-handed coordination helices used as precursors are prepared from l- and d-glutathione with Ag + and a small amount of Cu 2+ . The pyrolysis of the coordination helices yields right- and left-handed helices of Cu 0.12 Ag 1.94 S/C, which exhibit chiroptical activity spanning the entire visible light region. Finite element method simulations substantiate that the broadband chiroptical activity is attributed to synergistic broadband light absorption and light scattering. Furthermore, another series of Cu 0.10 Ag 1.90 S/C nanohelices are synthesized by choosing the l- or d-Glu-Cys as starting materials. The pitch length of nanohelicies is controlled by changing the peptides, which alters their chiroptical properties. The pyrolysis of coordination helices enables one to fabricate helical Ag 2 S-based materials that enable broadband chiroptical activity but have not been explored owing to the lack of synthetic routes.

Broadband Photometric Reverberation Mapping Analysis on SDSS-RM and Stripe 82 Quasars

NASA Astrophysics Data System (ADS)

Zhang, Haowen; Yang, Qian; Wu, Xuebing; Shen, Yue

2018-01-01

We extended the broadband photometric reverberation mapping (PRM) code, JAVELIN and test the availability to get broad line region (BLR) time delays that are consistent with spectroscopic reverberation mapping (SRM) projects. Broadband light curves of SDSS-RM quasars produced by convolution with system transmission curve were used in the test. We find that under similar sampling conditions (evenly and frequently sampled), the key factor determining whether the broadband PRM code can yield lags consistent with spectroscopic projects is the flux ratio of line to the reference continuum, which is in line with the findings in Zu et al. (2016). We further find a crucial line-to-continuum flux ratio, above which the mean of the ratios between the lags from PRM and SRM becomes closer to unity, and the scatter is pronouncedly reduced. Based on this flux ratio criteria, we selected some of the quasars from Hernitschek et al. (2015) and carry out broadband PRM on this subset. The performance of damped random walking (DRW) model and power-law (PL) structure function model on broadband PRM are compared using mock light curves with high, even cadences and low, uneven ones, respectively. We find that DRW model performs better in carrying out broadband PRM than PL model both for high and low cadence light curves with other data qualities similar to SDSS-RM quasars.

UHB engine fan broadband noise reduction study

NASA Astrophysics Data System (ADS)

Gliebe, Philip R.; Ho, Patrick Y.; Mani, Ramani

1995-06-01

A study has been completed to quantify the contribution of fan broadband noise to advanced high bypass turbofan engine system noise levels. The result suggests that reducing fan broadband noise can produce 3 to 4 EPNdB in engine system noise reduction, once the fan tones are eliminated. Further, in conjunction with the elimination of fan tones and an increase in bypass ratio, a potential reduction of 7 to 10 EPNdB in system noise can be achieved. In addition, an initial assessment of engine broadband noise source mechanisms has been made, concluding that the dominant source of fan broadband noise is the interaction of incident inlet boundary layer turbulence with the fan rotor. This source has two contributors, i.e., unsteady life dipole response and steady loading quadrupole response. The quadrupole contribution was found to be the most important component, suggesting that broadband noise reduction can be achieved by the reduction of steady loading field-turbulence field quadrupole interaction. Finally, for a controlled experimental quantification and verification, the study recommends that further broadband noise tests be done on a simulated engine rig, such as the GE Aircraft Engine Universal Propulsion Simulator, rather than testing on an engine statically in an outdoor arena The rig should be capable of generating forward and aft propagating fan noise, and it needs to be tested in a large freejet or a wind tunnel.

How to Choose a Media Retrieval System.

ERIC Educational Resources Information Center

Huber, Joe

1995-01-01

Provides guidelines for schools choosing a media retrieval system. Topics include broadband, baseband, coaxial cable, or fiber optic decisions; the control network; selecting scheduling software; presentation software; device control; control from the classroom; and a comparison of systems offered by five companies. (LRW)

47 CFR 90.1301 - Scope.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Wireless Broadband Services in the 3650-3700 MHz Band § 90.1301 Scope. This subpart sets out the regulations governing wireless operations in the 3650-3700 MHz band. It includes licensing...

47 CFR 90.1301 - Scope.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Wireless Broadband Services in the 3650-3700 MHz Band § 90.1301 Scope. This subpart sets out the regulations governing wireless operations in the 3650-3700 MHz band. It includes licensing...

47 CFR 90.1301 - Scope.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Wireless Broadband Services in the 3650-3700 MHz Band § 90.1301 Scope. This subpart sets out the regulations governing wireless operations in the 3650-3700 MHz band. It includes licensing...

47 CFR 90.1301 - Scope.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PRIVATE LAND MOBILE RADIO SERVICES Wireless Broadband Services in the 3650-3700 MHz Band § 90.1301 Scope. This subpart sets out the regulations governing wireless operations in the 3650-3700 MHz band. It includes licensing...

Miniature Incandescent Lamps as Fiber-Optic Light Sources

NASA Technical Reports Server (NTRS)

Tuma, Margaret; Collura, Joe; Helvajian, Henry; Pocha, Michael; Meyer, Glenn; McConaghy, Charles F.; Olsen, Barry L.

2008-01-01

Miniature incandescent lamps of a special type have been invented to satisfy a need for compact, rapid-response, rugged, broadband, power-efficient, fiber-optic-coupled light sources for diverse purposes that could include calibrating spectrometers, interrogating optical sensors, spot illumination, and spot heating.

Potential markets for advanced satellite communications

NASA Astrophysics Data System (ADS)

Adamson, Steven; Roberts, David; Schubert, Leroy; Smith, Brian; Sogegian, Robert; Walters, Daniel

1993-09-01

This report identifies trends in the volume and type of traffic offered to the U.S. domestic communications infrastructure and extrapolates these trends through the year 2011. To describe how telecommunications service providers are adapting to the identified trends, this report assesses the status, plans, and capacity of the domestic communications infrastructure. Cable, satellite, and radio components of the infrastructure are examined separately. The report also assesses the following major applications making use of the infrastructure: (1) Broadband services, including Broadband Integrated Services Digital Network (BISDN), Switched Multimegabit Data Service (SMDS), and frame relay; (2) mobile services, including voice, location, and paging; (3) Very Small Aperture Terminals (VSAT), including mesh VSAT; and (4) Direct Broadcast Satellite (DBS) for audio and video. The report associates satellite implementation of specific applications with market segments appropriate to their features and capabilities. The volume and dollar value of these market segments are estimated. For the satellite applications able to address the needs of significant market segments, the report also examines the potential of each satellite-based application to capture business from alternative technologies.

Tutorial: Integrated-photonic switching structures

NASA Astrophysics Data System (ADS)

Soref, Richard

2018-02-01

Recent developments in waveguided 2 × 2 and N × M photonic switches are reviewed, including both broadband and narrowband resonant devices for the Si, InP, and AlN platforms. Practical actuation of switches by electro-optical and thermo-optical techniques is discussed. Present datacom-and-computing applications are reviewed, and potential applications are proposed for chip-scale photonic and optoelectronic integrated switching networks. Potential is found in the reconfigurable, programmable "mesh" switches that enable a promising group of applications in new areas beyond those in data centers and cloud servers. Many important matrix switches use gated semiconductor optical amplifiers. The family of broadband, directional-coupler 2 × 2 switches featuring two or three side-coupled waveguides deserves future experimentation, including devices that employ phase-change materials. The newer 2 × 2 resonant switches include standing-wave resonators, different from the micro-ring traveling-wave resonators. The resonant devices comprise nanobeam interferometers, complex-Bragg interferometers, and asymmetric contra-directional couplers. Although the fast, resonant devices offer ultralow switching energy, ˜1 fJ/bit, they have limitations. They require several trade-offs when deployed, but they do have practical application.

Potential markets for advanced satellite communications

NASA Technical Reports Server (NTRS)

Adamson, Steven; Roberts, David; Schubert, Leroy; Smith, Brian; Sogegian, Robert; Walters, Daniel

1993-01-01

This report identifies trends in the volume and type of traffic offered to the U.S. domestic communications infrastructure and extrapolates these trends through the year 2011. To describe how telecommunications service providers are adapting to the identified trends, this report assesses the status, plans, and capacity of the domestic communications infrastructure. Cable, satellite, and radio components of the infrastructure are examined separately. The report also assesses the following major applications making use of the infrastructure: (1) Broadband services, including Broadband Integrated Services Digital Network (BISDN), Switched Multimegabit Data Service (SMDS), and frame relay; (2) mobile services, including voice, location, and paging; (3) Very Small Aperture Terminals (VSAT), including mesh VSAT; and (4) Direct Broadcast Satellite (DBS) for audio and video. The report associates satellite implementation of specific applications with market segments appropriate to their features and capabilities. The volume and dollar value of these market segments are estimated. For the satellite applications able to address the needs of significant market segments, the report also examines the potential of each satellite-based application to capture business from alternative technologies.

Evaluation of arctic broadband surface radiation measurements

NASA Astrophysics Data System (ADS)

Matsui, N.; Long, C. N.; Augustine, J.; Halliwell, D.; Uttal, T.; Longenecker, D.; Nievergall, O.; Wendell, J.; Albee, R.

2011-08-01

The Arctic is a challenging environment for making in-situ radiation measurements. A standard suite of radiation sensors is typically designed to measure the total, direct and diffuse components of incoming and outgoing broadband shortwave (SW) and broadband thermal infrared, or longwave (LW) radiation. Enhancements can include various sensors for measuring irradiance in various narrower bandwidths. Many solar radiation/thermal infrared flux sensors utilize protective glass domes and some are mounted on complex mechanical platforms (solar trackers) that rotate sensors and shading devices that track the sun. High quality measurements require striking a balance between locating sensors in a pristine undisturbed location free of artificial blockage (such as buildings and towers) and providing accessibility to allow operators to clean and maintain the instruments. Three significant sources of erroneous data include solar tracker malfunctions, rime/frost/snow deposition on the instruments and operational problems due to limited operator access in extreme weather conditions. In this study, a comparison is made between the global and component sum (direct [vertical component] + diffuse) shortwave measurements. The difference between these two quantities (that theoretically should be zero) is used to illustrate the magnitude and seasonality of radiation flux measurement problems. The problem of rime/frost/snow deposition is investigated in more detail for one case study utilizing both shortwave and longwave measurements. Solutions to these operational problems are proposed that utilize measurement redundancy, more sophisticated heating and ventilation strategies and a more systematic program of operational support and subsequent data quality protocols.

ACTS broadband aeronautical experiment

NASA Technical Reports Server (NTRS)

Abbe, Brian S.; Jedrey, Thomas C.; Estabrook, Polly; Agan, Martin J.

1993-01-01

In the last decade, the demand for reliable data, voice, and video satellite communication links between aircraft and ground to improve air traffic control, airline management, and to meet the growing demand for passenger communications has increased significantly. It is expected that in the near future, the spectrum required for aeronautical communication services will grow significantly beyond that currently available at L-band. In anticipation of this, JPL is developing an experimental broadband aeronautical satellite communications system that will utilize NASA's Advanced Communications Technology Satellite (ACTS) as a satellite of opportunity and the technology developed under JPL's ACTS Mobile Terminal (AMT) Task to evaluate the feasibility of using K/Ka-band for these applications. The application of K/Ka-band for aeronautical satellite communications at cruise altitudes is particularly promising for several reasons: (1) the minimal amount of signal attenuation due to rain; (2) the reduced drag due to the smaller K/Ka-band antennas (as compared to the current L-band systems); and (3) the large amount of available bandwidth. The increased bandwidth available at these frequencies is expected to lead to significantly improved passenger communications - including full-duplex compressed video and multiple channel voice. A description of the proposed broadband experimental system will be presented including: (1) applications of K/Ka-band aeronautical satellite technology to U.S. industry; (2) the experiment objectives; (3) the experiment set-up; (4) experimental equipment description; and (5) industrial participation in the experiment and the benefits.

The Broadband Quandary for Rural America. The Main Street Economist: Commentary on the Rural Economy.

ERIC Educational Resources Information Center

Staihr, Brian

High speed data services known as broadband have the potential to make rural areas less isolated and improve the rural quality of life, but physical barriers, sparse population density, and few markets present significant obstacles to their deployment in rural areas. Broadband applications such as e-commerce, distance education, and telemedicine…

The Feasibility and Value of Broadband Communications in Rural Areas. A Preliminary Evaluation, April 1976.

ERIC Educational Resources Information Center

Mills, William; And Others

The study was conducted to determine the feasibility and value of using broadband communications (transmission of many television, voice and/or data signals through a single system) to provide public services for rural areas. Applications of broadband communications to rural areas were divided into public services (health, education, law…

76 FR 40817 - Implementation of Section 224 of the Act; A National Broadband Plan for Our Future

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-12

...-50] Implementation of Section 224 of the Act; A National Broadband Plan for Our Future AGENCY... information collection requirements. The Office of Management and Budget (OMB) gave approval for these..., Implementation of Section 224 of the Act; A National Broadband Plan for Our Future. DATES: The final rules...

Exploring Geographic Disparities in Broadband Access and Use in Rural Southern Illinois: Who's Being Left behind?

ERIC Educational Resources Information Center

Oyana, Tonny J.

2011-01-01

Recent literature about broadband telecommunications reveals two major areas that are not only globally gaining prominence, but are also demanding urgent attention from a research perspective. One of the key areas is related to the need to spatially evaluate the availability and deployment of broadband services, especially among urban versus rural…

Beyond the Glow: Children's Broadband Access, Digital Learning Initiatives, and Academic Achievement in Rural Florida

ERIC Educational Resources Information Center

Mardis, Marcia

2016-01-01

Approximately 26 million Americans have no access to broadband's social and economic benefits. A persistent level of non-adoption stems from adults' lack of perceived need or benefit. Florida's unique move to all digital instructional materials and required online learning by 2015 may make home broadband essential for maintaining a learning…

Community-Based Broadband Solutions: The Benefits of Competition and Choice for Community Development and Highspeed Internet Access

ERIC Educational Resources Information Center

Executive Office of the President, 2015

2015-01-01

Affordable, reliable access to high speed broadband is critical to U.S. economic growth and competitiveness. Upgrading to higher-speed broadband lets consumers use the Internet in new ways, increases the productivity of American individuals and businesses, and drives innovation throughout the digital ecosystem. As this report describes, while the…

Western Cape Subject Advisors' Perception of Their Preparedness for Connected Classrooms

ERIC Educational Resources Information Center

Chigona, Agnes

2017-01-01

In South Africa, the Western Cape government (WCG)'s current broadband strategy aims to ensure that all schools will be connected to broadband service within a reasonable time-frame. According to the WCG integration of ICTs and the broadband will remove the digital divide and enhance curriculum delivery in schools. To achieve this, sensible…

Landing Gear Door Liners for Airframe Noise Reduction

NASA Technical Reports Server (NTRS)

Jones, Michael G. (Inventor); Howerton, Brian M. (Inventor); Van De Ven, Thomas (Inventor)

2014-01-01

A landing gear door for retractable landing gear of aircraft includes an acoustic liner. The acoustic liner includes one or more internal cavities or chambers having one or more openings that inhibit the generation of sound at the surface and/or absorb sound generated during operation of the aircraft. The landing gear door may include a plurality of internal chambers having different geometries to thereby absorb broadband noise.

Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody.

PubMed

Winkler, Mark T; Bushey, Ryan T; Gottlin, Elizabeth B; Campa, Michael J; Guadalupe, Eross S; Volkheimer, Alicia D; Weinberg, J Brice; Patz, Edward F

2017-01-01

Rituximab therapy for B cell chronic lymphocytic leukemia (B-CLL) has met with mixed success. Among several factors to which resistance can be attributed is failure to activate complement dependent cytotoxicity (CDC) due to protective complement regulatory proteins, including the soluble regulator complement factor H (CFH). We hypothesized that rituximab killing of non-responsive B-CLL cells could be augmented by a novel human monoclonal antibody against CFH. The B cells from 11 patients with B-CLL were tested ex vivo in CDC assays with combinations of CFH monoclonal antibody, rituximab, and a negative control antibody. CDC of rituximab non-responsive malignant B cells from CLL patients could in some cases be augmented by the CFH monoclonal antibody. Antibody-mediated cytotoxicity of cells was dependent upon functional complement. In one case where B-CLL cells were refractory to CDC by the combination of rituximab plus CFH monoclonal antibody, additionally neutralizing the membrane complement regulatory protein CD59 allowed CDC to occur. Inhibiting CDC regulatory proteins such as CFH holds promise for overcoming resistance to rituximab therapy in B-CLL.

Further Development and Assessment of a Broadband Liner Optimization Process

NASA Technical Reports Server (NTRS)

Nark, Douglas M.; Jones, Michael G.; Sutliff, Daniel L.

2016-01-01

The utilization of advanced fan designs (including higher bypass ratios) and shorter engine nacelles has highlighted a need for increased fan noise reduction over a broader frequency range. Thus, improved broadband liner designs must account for these constraints and, where applicable, take advantage of advanced manufacturing techniques that have opened new possibilities for novel configurations. This work focuses on the use of an established broadband acoustic liner optimization process to design a variable-depth, multi-degree of freedom liner for a high speed fan. Specifically, in-duct attenuation predictions with a statistical source model are used to obtain optimum impedance spectra over the conditions of interest. The predicted optimum impedance information is then used with acoustic liner modeling tools to design a liner aimed at producing impedance spectra that most closely match the predicted optimum values. The multi-degree of freedom design is carried through design, fabrication, and testing. In-duct attenuation predictions compare well with measured data and the multi-degree of freedom liner is shown to outperform a more conventional liner over a range of flow conditions. These promising results provide further confidence in the design tool, as well as the enhancements made to the overall design process.

Broadband photodetector based on carbon nanotube thin film/single layer graphene Schottky junction

NASA Astrophysics Data System (ADS)

Zhang, Teng-Fei; Li, Zhi-Peng; Wang, Jiu-Zhen; Kong, Wei-Yu; Wu, Guo-An; Zheng, Yu-Zhen; Zhao, Yuan-Wei; Yao, En-Xu; Zhuang, Nai-Xi; Luo, Lin-Bao

2016-12-01

In this study, we present a broadband nano-photodetector based on single-layer graphene (SLG)-carbon nanotube thin film (CNTF) Schottky junction. It was found that the as-fabricated device exhibited obvious sensitivity to a wide range of illumination, with peak sensitivity at 600 and 920 nm. In addition, the SLG-CNTF device had a fast response speed (τr = 68 μs, τf = 78 μs) and good reproducibility in a wide range of switching frequencies (50-5400 Hz). The on-off ratio, responsivity, and detectivity of the device were estimated to be 1 × 102, 209 mAW-1 and 4.87 × 1010 cm Hz1/2 W-1, respectively. What is more, other device parameters including linear performance θ and linear dynamic range (LDR) were calculated to be 0.99 and 58.8 dB, respectively, which were relatively better than other carbon nanotube based devices. The totality of the above study signifies that the present SLG-CNTF Schottky junction broadband nano-photodetector may have promising application in future nano-optoelectronic devices and systems.

Design principles for morphologies of antireflection patterns for solar absorbing applications.

PubMed

Moon, Yoon-Jong; Na, Jin-Young; Kim, Sun-Kyung

2015-07-01

Two-dimensional surface texturing is a widespread technology for imparting broadband antireflection, yet its design rules are not completely understood. The dependence of the reflectance spectrum of a periodically patterned glass film on various structural parameters (e.g., pitch, height, shape, and fill factor) has been investigated by means of full-vectorial numerical simulations. An average weighted reflectivity accounting for the AM1.5G solar spectrum (λ=300-1000  nm) was sinusoidally modulated by a rod pattern's height, and was minimized for pitches of 400-600 nm. When a rationally optimized cone pattern was used, the average weighted reflectivity was less than 0.5%, for incident angles of up to 40° off normal. The broadband antireflection of a cone pattern was reproduced well by a graded refractive index film model corresponding to its geometry, with the addition of a diffraction effect resulting from its periodicity. The broadband antireflection ability of optimized cone patterns is not limited to the glass material, but rather is generically applicable to other semiconductor materials, including Si and GaAs. The design rules developed herein represent a key step in the development of light-absorbing devices, such as solar cells.

HERA Broadband Feed Design for Low-Frequency Radio Astronomy

NASA Astrophysics Data System (ADS)

Garza, Sierra; Trung, Vincent; Ewall-Wice, Aaron Michael; Li, Jianshu; Hewitt, Jacqueline; Riley, Daniel; Bradley, Richard F.; Makhija, Krishna

2018-01-01

As part of the Hydrogen Epoch of Reionization Array (HERA) project, we are designing a broadband low-frequency radio feed to extend the bandwidth from 100-200 MHz to 50-220 MHz. By extending the lower-limit to 50 MHz, we hope to detect the signatures of the first black holes heating the hydrogen gas in the intergalactic medium.The isolation of a very faint signal from vastly brighter foregrounds sets strict requirements on antenna spectral smoothness, polarization purity, forward gain, and internal reflections. We are currently working to meet these requirements with a broad-band sinuous antenna feed suspended over the 14-m parabolic HERA dish, using a combination of measurements and simulations to verify the performance of our design.A sinuous feed has been designed and simulated with Computer Simulation Technology (CST) software. We will present the construction of a prototype sinuous antenna and measurements of its reflection coefficient, S11, including laboratory characterization of baluns. Our measurements agree well with the CST simulations of the antenna’s performance, giving us confidence in our ability to model the feed and ensure that it meets the requirements of a 21cm cosmology measurement.

Broadband spectral fitting of blazars using XSPEC

NASA Astrophysics Data System (ADS)

Sahayanathan, Sunder; Sinha, Atreyee; Misra, Ranjeev

2018-03-01

The broadband spectral energy distribution (SED) of blazars is generally interpreted as radiation arising from synchrotron and inverse Compton mechanisms. Traditionally, the underlying source parameters responsible for these emission processes, like particle energy density, magnetic field, etc., are obtained through simple visual reproduction of the observed fluxes. However, this procedure is incapable of providing confidence ranges for the estimated parameters. In this work, we propose an efficient algorithm to perform a statistical fit of the observed broadband spectrum of blazars using different emission models. Moreover, we use the observable quantities as the fit parameters, rather than the direct source parameters which govern the resultant SED. This significantly improves the convergence time and eliminates the uncertainty regarding initial guess parameters. This approach also has an added advantage of identifying the degenerate parameters, which can be removed by including more observable information and/or additional constraints. A computer code developed based on this algorithm is implemented as a user-defined routine in the standard X-ray spectral fitting package, XSPEC. Further, we demonstrate the efficacy of the algorithm by fitting the well sampled SED of blazar 3C 279 during its gamma ray flare in 2014.

RXTE Observations of the 1A 1118-61 in an Outburst, and the Discovery of a Cyclotron Line

NASA Technical Reports Server (NTRS)

Doroshenko, V.; Suchy, S.; Santangelo, A; Staubert, R.; Kreykenbohm, I.; Rothschild, R.; Pottschmidt, K.; Wilms, J.

2010-01-01

We present the analysis of RXTE monitoring data obtained during the January 2009 outburst of the hard X-ray transient IA 1118-61. Using these observations the broadband (3.5-120 keV) spectrum of the source was measured for the first time ever. We have found that the broadband continuum spectrum of the source is similar to other accreting pulsars and is well described by several conventionally used phenomenological models. We have discovered that regardless of the applied continuum model, a prominent broad absorption feature at approx. 55 keV is observed. We interpret this feature as a Cyclotron Resonance Scattering Feature (CRSF). The observed CRSF energy is one of the highest known and corresponds to a magnetic field of B approx. 4.8 x 10(exp 12) G in the scattering region. Furthermore, our data suggests an iron emission line presence, which was not reported previously for lA 1118-61 as well. Timing properties of the source, including a strong spin-up, were found to be similar to those observed by CGRO/BATSE during the previous outburst, however the broadband capabilities of RXTE reveal a more complicated energy dependency of the pulse-profile.

Broadband photodetector based on carbon nanotube thin film/single layer graphene Schottky junction

PubMed Central

Zhang, Teng-Fei; Li, Zhi-Peng; Wang, Jiu-Zhen; Kong, Wei-Yu; Wu, Guo-An; Zheng, Yu-Zhen; Zhao, Yuan-Wei; Yao, En-Xu; Zhuang, Nai-Xi; Luo, Lin-Bao

2016-01-01

In this study, we present a broadband nano-photodetector based on single-layer graphene (SLG)-carbon nanotube thin film (CNTF) Schottky junction. It was found that the as-fabricated device exhibited obvious sensitivity to a wide range of illumination, with peak sensitivity at 600 and 920 nm. In addition, the SLG-CNTF device had a fast response speed (τr = 68 μs, τf = 78 μs) and good reproducibility in a wide range of switching frequencies (50–5400 Hz). The on-off ratio, responsivity, and detectivity of the device were estimated to be 1 × 102, 209 mAW−1 and 4.87 × 1010 cm Hz1/2 W−1, respectively. What is more, other device parameters including linear performance θ and linear dynamic range (LDR) were calculated to be 0.99 and 58.8 dB, respectively, which were relatively better than other carbon nanotube based devices. The totality of the above study signifies that the present SLG-CNTF Schottky junction broadband nano-photodetector may have promising application in future nano-optoelectronic devices and systems. PMID:27929053

Secure and interoperable communication infrastructures for PPDR organisations

NASA Astrophysics Data System (ADS)

Müller, Wilmuth; Marques, Hugo; Pereira, Luis; Rodriguez, Jonathan; Brouwer, Frank; Bouwers, Bert; Politis, Ilias; Lykourgiotis, Asimakis; Ladas, Alexandros; Adigun, Olayinka; Jelenc, David

2016-05-01

The growing number of events affecting public safety and security (PS&S) on a regional scale with potential to grow up to large scale cross border disasters puts an increased pressure on agencies and organisation responsible for PS&S. In order to respond timely and in an adequate manner to such events, Public Protection and Disaster Relief (PPDR) organisations need to cooperate, align their procedures and activities, share the needed information and be interoperable. Existing PPDR/PMR technologies such as TETRA, TETRAPOL or P25, do not currently provide broadband capability nor is expected such technologies to be upgraded in the future. This presents a major limitation in supporting new services and information flows. Furthermore, there is no known standard that addresses interoperability of these technologies. In this contribution the design of a next generation communication infrastructure for PPDR organisations which fulfills the requirements of secure and seamless end-to-end communication and interoperable information exchange within the deployed communication networks is presented. Based on Enterprise Architecture of PPDR organisations, a next generation PPDR network that is backward compatible with legacy communication technologies is designed and implemented, capable of providing security, privacy, seamless mobility, QoS and reliability support for mission-critical Private Mobile Radio (PMR) voice and broadband data services. The designed solution provides a robust, reliable, and secure mobile broadband communications system for a wide variety of PMR applications and services on PPDR broadband networks, including the ability of inter-system, interagency and cross-border operations with emphasis on interoperability between users in PMR and LTE.

Multidisciplinary Observations of Subduction (MOOS) Experiment in South-Central Alaska

NASA Astrophysics Data System (ADS)

Christensen, D.; Abers, G.; Freymueller, J.

2008-12-01

Seismic and geodetic data are being collected in the Kenai Peninsula and surrounding area of south central Alaska as part of the PASSCAL experiment MOOS. A total of 34 broadband seismic stations were deployed between the summers of 2007 and 2008. Seventeen of these stations continue to operate for an additional year and are scheduled to be removed in the summer of 2009. Numerous GPS campaign sites have and will be visited during the same time period. The MOOS seismic deployment provides coverage across the interplate coupled zone and adjacent transition zone in the shallow parts of the Alaskan subduction zone. It is a southern extension of an earlier broadband deployment BEAAR (Broadband Experiment Across the Alaska Range) to the north. When integrated with the previous BEAAR experiment, these data will allow high-resolution broadband imaging along a 600 km long transect over the Alaska subduction zone, at 10-15 km station spacing. The MOOS deployment allows us to test several hypotheses relating to the postulated subduction of the Yakutat Block and the nature of the coupled zone which ruptured in the great 1964 earthquake. The seismic and geodetic stations cover an area that includes part of the 1964 main asperity and the adjacent, less coupled, region to the southwest. Data gathered from this experiment will shed light on the nature of this boundary from both a geodetic and seismic (or earth structure) perspective. Shallow seismicity recorded by this network greatly improves the catalog of events in this area and helps to delineate active features in the subduction complex. Preliminary results from this project will be presented.

Defining the Complement Biomarker Profile of C3 Glomerulopathy

PubMed Central

Zhang, Yuzhou; Nester, Carla M.; Martin, Bertha; Skjoedt, Mikkel-Ole; Meyer, Nicole C.; Shao, Dingwu; Borsa, Nicolò; Palarasah, Yaseelan

2014-01-01

Background and objectives C3 glomerulopathy (C3G) applies to a group of renal diseases defined by a specific renal biopsy finding: a dominant pattern of C3 fragment deposition on immunofluorescence. The primary pathogenic mechanism involves abnormal control of the alternative complement pathway, although a full description of the disease spectrum remains to be determined. This study sought to validate and define the association of complement dysregulation with C3G and to determine whether specific complement pathway abnormalities could inform disease definition. Design, setting, participants, & measurements This study included 34 patients with C3G (17 with C3 glomerulonephritis [C3GN] and 17 with dense deposit disease [DDD]) diagnosed between 2008 and 2013 selected from the C3G Registry. Control samples (n=100) were recruited from regional blood drives. Nineteen complement biomarkers were assayed on all samples. Results were compared between C3G disease categories and with normal controls. Results Assessment of the alternative complement pathway showed that compared with controls, patients with C3G had lower levels of serum C3 (P<0.001 for both DDD and C3GN) and factor B (P<0.001 for both DDD and C3GN) as well as higher levels of complement breakdown products including C3d (P<0.001 for both DDD and C3GN) and Bb (P<0.001 for both DDD and C3GN). A comparison of terminal complement pathway proteins showed that although C5 levels were significantly suppressed (P<0.001 for both DDD and C3GN) its breakdown product C5a was significantly higher only in patients with C3GN (P<0.05). Of the other terminal pathway components (C6–C9), the only significant difference was in C7 levels between patients with C3GN and controls (P<0.01). Soluble C5b-9 was elevated in both diseases but only the difference between patients with C3GN and controls reached statistical significance (P<0.001). Levels of C3 nephritic factor activity were qualitatively higher in patients with DDD compared with patients with C3GN. Conclusions Complement biomarkers are significantly abnormal in patients with C3G compared with controls. These data substantiate the link between complement dysregulation and C3G and identify C3G interdisease differences. PMID:25341722

Complement Activation Alters Platelet Function

DTIC Science & Technology

2015-12-01

haemostatic and coagulation properties of platelets. 15. SUBJECT TERMS Platelets, Complement, Trauma, Tissue Damage 16. SECURITY CLASSIFICATION... coagulation , there is mounting evidence that they may also be important in the development and progression of inflammatory processes (Coppinger et al...receptor-ligand interactions and/or through exposure to cytokines including IL-6, other acute-phase reactants, and pro- coagulant factors such as thrombin

Aspects of the Acquisition of Object Control and ECM-Type Verbs in European Portuguese

ERIC Educational Resources Information Center

Santos, Ana Lúcia; Gonçalves, Anabela; Hyams, Nina

2016-01-01

We investigate the acquisition of sentential complementation under causative, perception, and object control verbs in European Portuguese, a language rich in complement types, including the typologically marked inflected infinitives. We tested 58 children between 3 and 5 years of age and 24 adults on a sentence completion task. The results support…

Broadband/Wideband Magnetoelectric Response

DOE PAGES

Park, Chee-Sung; Priya, Shashank

2012-01-01

A broadband/wideband magnetoelectric (ME) composite offers new opportunities for sensing wide ranges of both DC and AC magnetic fields. The broadband/wideband behavior is characterized by flat ME response over a given AC frequency range and DC magnetic bias. The structure proposed in this study operates in the longitudinal-transversal (L-T) mode. In this paper, we provide information on (i) how to design broadband/wideband ME sensors and (ii) how to control the magnitude of ME response over a desired frequency and DC bias regime. A systematic study was conducted to identify the factors affecting the broadband/wideband behavior by developing experimental models andmore » validating them against the predictions made through finite element modeling. A working prototype of the sensor with flat bands for both DC and AC magnetic field conditions was successfully obtained. These results are quite promising for practical applications such as current probe, low-frequency magnetic field sensing, and ME energy harvester.« less

Broadband and broadangle SPP antennas based on plasmonic crystals with linear chirp.

PubMed

Bouillard, J-S; Vilain, S; Dickson, W; Wurtz, G A; Zayats, A V

2012-01-01

Plasmonic technology relies on the coupling of light to surface electromagnetic modes on smooth or structured metal surfaces. While some applications utilise the resonant nature of surface polaritons, others require broadband characteristics. We demonstrate unidirectional and broadband plasmonic antennas with large acceptance angles based on chirped plasmonic gratings. Near-field optical measurements have been used to visualise the excitation of surface plasmon polaritons by such aperiodic structures. These weakly aperiodic plasmonic crystals allow the formation of a trapped rainbow-type effect in a two-dimensional geometry as surface polaritons of different frequencies are coherently excited in different locations over the plasmonic structure. Both the crystal's finite size and the finite lifetime of plasmonic states are crucial for the generation of broadband surface plasmon polaritons. This approach presents new opportunities for building unidirectional, broadband and broad-angle plasmonic couplers for sensing purposes, information processing, photovoltaic applications and shaping and manipulating ultrashort optical pulses.

Evaluation of the annoyance due to helicopter rotor noise

NASA Technical Reports Server (NTRS)

Sternfeld, H., Jr.; Doyle, L. B.

1978-01-01

A program was conducted in which 25 test subjects adjusted the levels of various helicopter rotor spectra until the combination of the harmonic noise and a broadband background noise was judged equally annoying as a higher level of the same broadband noise spectrum. The subjective measure of added harmonic noise was equated to the difference in the two levels of broadband noise. The test participants also made subjective evaluations of the rotor noise signatures which they created. The test stimuli consisted of three degrees of rotor impulsiveness, each presented at four blade passage rates. Each of these 12 harmonic sounds was combined with three broadband spectra and was adjusted to match the annoyance of three different sound pressure levels of broadband noise. Analysis of variance indicated that the important variables were level and impulsiveness. Regression analyses indicated that inclusion of crest factor improved correlation between the subjective measures and various objective or physical measures.

Broadband and broadangle SPP antennas based on plasmonic crystals with linear chirp

PubMed Central

Bouillard, J.-S; Vilain, S.; Dickson, W.; Wurtz, G. A.; Zayats, A. V.

2012-01-01

Plasmonic technology relies on the coupling of light to surface electromagnetic modes on smooth or structured metal surfaces. While some applications utilise the resonant nature of surface polaritons, others require broadband characteristics. We demonstrate unidirectional and broadband plasmonic antennas with large acceptance angles based on chirped plasmonic gratings. Near-field optical measurements have been used to visualise the excitation of surface plasmon polaritons by such aperiodic structures. These weakly aperiodic plasmonic crystals allow the formation of a trapped rainbow-type effect in a two-dimensional geometry as surface polaritons of different frequencies are coherently excited in different locations over the plasmonic structure. Both the crystal's finite size and the finite lifetime of plasmonic states are crucial for the generation of broadband surface plasmon polaritons. This approach presents new opportunities for building unidirectional, broadband and broad-angle plasmonic couplers for sensing purposes, information processing, photovoltaic applications and shaping and manipulating ultrashort optical pulses. PMID:23170197

Making structured metals transparency for broadband and wide-incidence-angle electromagnetic waves

NASA Astrophysics Data System (ADS)

Fan, Renhao; Peng, Ruwen; Huang, Xianrong; Wang, Mu

2014-03-01

Very recently, we have demonstrated that one-dimensional metallic gratings can become transparent and completely antireflective for extremely broadband electromagnetic (EM) waves under oblique incidence. However, the oblique-incidence geometry, is inconvenient for the technological applications. To overcome this drawback, here we instead use oblique metal gratings with optimal tilt angles to achieve normal-incidence broadband transparence for EM waves. Further we use two-dimensional periodic metallic cuboids to achieve broadband and broad-angle high transmission and antireflection. By introducing such metallic cuboids arrays into silicon solar cells, we find that high performance of light trapping in the cells can be obtained with a significant enhancement of the ultimate quantum efficiency. The structured metals, which achieve broadband and broad-angle high transmission for EM waves, may have many other potential applications, such as transparent conducting panels, white-beam polarizers, and stealth objects.

Anti-complement activities of human breast-milk.

PubMed

Ogundele, M O

1999-08-01

It has long been observed that the human milk possesses significant anti-inflammatory properties, while simultaneously protecting the infant against many intestinal and respiratory pathogens. There is, however, a paucity of information on the degree and extent of this anti-inflammatory activity. In the present study, the inhibitory effects of different fractions of human milk on serum complement activity were analysed. Colostrum and milk samples from healthy voluntary lactating donors at different postpartum ages were obtained and pooled normal human serum was used as source of complement in a modified CH50 assay. Inherent complement activity in human milk was also investigated by measuring the deposition of an activated C3 fragment on a serum-sensitive bacteria, and by haemolytic assays. Most whole- and defatted-milk samples consistently showed a dose-dependent inhibition of the serum complement activity. This inhibition was greater in mature milk compared to transitional milk samples. It was enhanced by inactivation of milk complement, and diminished by centrifugation of milk samples, which partly removed fat and larger protein components including casein micelles. Inherent complement activity in human milk was also demonstrated by haemolysis of sensitised sheep erythrocytes and deposition of C3 fragments on solid-phase bacteria. These activities were highest in the colostrum and gradually decreased as lactation proceeded. Several natural components abundant in the fluid phase of the human breast-milk have been shown to be inhibitors of complement activation in vitro. Their physiological significance probably reside in their ability to prevent inflammatory-induced tissue damage of the delicate immature gastrointestinal tract of the new-born as well as the mammary gland itself, which may arise from ongoing complement activation.

A comprehensive strategy for the subtyping of patients with Fanconi anaemia: conclusions from the Spanish Fanconi Anemia Research Network.

PubMed

Antonio Casado, José; Callén, Elsa; Jacome, Ariana; Río, Paula; Castella, Maria; Lobitz, Stephan; Ferro, Teresa; Muñoz, Arturo; Sevilla, Julián; Cantalejo, Angeles; Cela, Elena; Cervera, José; Sánchez-Calero, Jesús; Badell, Isabel; Estella, Jesús; Dasí, Angeles; Olivé, Teresa; José Ortega, Juan; Rodriguez-Villa, Antonia; Tapia, María; Molinés, Antonio; Madero, Luis; Segovia, José C; Neveling, Kornelia; Kalb, Reinhard; Schindler, Detlev; Hanenberg, Helmut; Surrallés, Jordi; Bueren, Juan A

2007-04-01

Fanconi anaemia is a heterogeneous genetic disease, where 12 complementation groups have been already described. Identifying the complementation group in patients with Fanconi anaemia constitutes a direct procedure to confirm the diagnosis of the disease and is required for the recruitment of these patients in gene therapy trials. To determine the subtype of Fanconi anaemia patients in Spain, a Mediterranean country with a relatively high population (23%) of Fanconi anaemia patients belonging to the gypsy race. Most patients could be subtyped by retroviral complementation approaches in peripheral blood T cells, although some mosaic patients were subtyped in cultured skin fibroblasts. Other approaches, mainly based on western blot analysis and generation of nuclear RAD51 and FANCJ foci, were required for the subtyping of a minor number of patients. From a total of 125 patients included in the Registry of Fanconi Anaemia, samples from 102 patients were available for subtyping analyses. In 89 cases the subtype could be determined and in 8 cases exclusions of common complementation groups were made. Compared with other international studies, a skewed distribution of complementation groups was observed in Spain, where 80% of the families belonged to the Fanconi anaemia group A (FA-A) complementation group. The high proportion of gypsy patients, all of them FA-A, and the absence of patients with FA-C account for this characteristic distribution of complementation groups.

Advanced spectral processing of broadband light using acousto-optic devices with arbitrary transmission functions.

PubMed

Molchanov, Vladimir Ya; Yushkov, Konstantin B

2014-06-30

In the paper, we developed a dispersive method for transmission function synthesis of collinear and quasi-collinear acousto-optic tunable filters. General theoretical consideration was performed, and modelling was made for broadband and narrowband signals. Experimental results on spectral shaping of femtosecond laser emission were obtained. Binary spectral encoding of broadband emission was demonstrated.

Performance of Complex Spreading MIMO Systems With Interference

DTIC Science & Technology

2011-06-01

14 III. PERFORMANCE ANALYSIS OF DS -PSK MISO ...............................................15 A. SYSTEM DESCRIPTION...15 Figure 9. BER of DS PSK system for broadband jamming and diversity L=1. ..............20 Figure 10. BER of DS PSK system for...broadband jamming and diversity L=2. .............21 Figure 11. BER of DS PSK system for broadband jamming and diversity L=3. ..............22 Figure 12

Perceived Benefits and Barriers to the Use of High-Speed Broadband in Ireland's Second-Level Schools

ERIC Educational Resources Information Center

Coyne, Bryan; Devitt, Niamh; Lyons, Seán; McCoy, Selina

2015-01-01

As part of Ireland's National Digital Strategy, high-speed broadband is being rolled out to all second-level schools to support greater use of information and communication technology (ICT) in education. This programme signals a move from slow and unreliable broadband connections for many schools to a guaranteed high-speed connection with…

76 FR 32901 - The Provision of Fixed and Mobile Broadband Access, Educational and Other Advanced Services in...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-07

....5 megahertz from the channel edge, where (P) is the transmitter power measured in watts. 5.5... broadband applications. Another standard for wireless broadband technology is Long Term Evolution (LTE... refinements of WiMAX and LTE, which are known as WiMAX 2 (based on the 802.16m standard and LTE- Advanced...

Broadband nanophotonic wireless links and networks using on-chip integrated plasmonic antennas.

PubMed

Yang, Yuanqing; Li, Qiang; Qiu, Min

2016-01-19

Owing to their high capacity and flexibility, broadband wireless communications have been widely employed in radio and microwave regimes, playing indispensable roles in our daily life. Their optical analogs, however, have not been demonstrated at the nanoscale. In this paper, by exploiting plasmonic nanoantennas, we demonstrate the complete design of broadband wireless links and networks in the realm of nanophotonics. With a 100-fold enhancement in power transfer superior to previous designs as well as an ultrawide bandwidth that covers the entire telecommunication wavelength range, such broadband nanolinks and networks are expected to pave the way for future optical integrated nanocircuits.

Digital Collections, Digital Libraries and the Digitization of Cultural Heritage Information.

ERIC Educational Resources Information Center

Lynch, Clifford

2002-01-01

Discusses the development of digital collections and digital libraries. Topics include digitization of cultural heritage information; broadband issues; lack of compelling content; training issues; types of materials being digitized; sustainability; digital preservation; infrastructure; digital images; data mining; and future possibilities for…

Fiber Optics: Deregulate and Deploy.

ERIC Educational Resources Information Center

Suwinski, Jan H.

1993-01-01

Describes fiber optic technology, explains its use in education and commercial settings, and recommends regulations and legislation that will speed its use to create broadband information networks. Topics discussed include distance learning; interactive video; costs; and the roles of policy makers, lawmakers, public advocacy groups, and consumers.…

A Theoretical Foundation for Understanding Clergy-Perpetrated Sexual Abuse

ERIC Educational Resources Information Center

Fogler, Jason M.; Shipherd, Jillian C.; Rowe, Erin; Jensen, Jennifer; Clarke, Stephanie

2008-01-01

Incorporating elements from broadband theories of psychological adaptation to extreme adversity, including Summit's (1983) Child Sexual Abuse Accommodation Syndrome, Finkelhor and Browne's (1986) Traumagenic Dynamics Model of sexual abuse, and Pyszczynski and colleagues' (1997) Terror Management Theory, this paper proposes a unified theoretical…

Enhancing Image Processing Performance for PCID in a Heterogeneous Network of Multi-core Processors

DTIC Science & Technology

2009-09-01

TFLOPS of Playstation 3 (PS3) nodes with IBM Cell Broadband Engine multi-cores and 15 dual-quad Xeon head nodes. The interconnect fabric includes... 4   3. INFORMATION MANAGEMENT FOR PARALLELIZATION AND...STREAMING............................................................. 7  4 . RESULTS

Investigation of broadband digital predistortion for broadband radio over fiber transmission systems

NASA Astrophysics Data System (ADS)

Zhang, Xiupu; Liu, Taijun; Shen, Dongya

2016-12-01

In future broadband cloud radio access networks (C-RAN), front-haul transmission systems play a significant role in performance and cost of C-RAN. Broadband and high linearity radio over fiber (RoF) transmission systems are considered a promising solution for the front-haul. Digital linearization is one possible solution for RoF front-haul. In this paper, we investigate RF domain digital predistortion (DPD) linearization for broadband RoF front-haul. The implemented DPD is first investigated in 2.4 GHz WiFi over fiber transmission systems at 36 Mb/s, and more than 8-dB and 5.6-dB improvements of error vector magnitude (EVM) are achieved in back to back (BTB) and after 10 km single mode fiber (SMF) transmission. Further, both WiFi and ultra wide band (UWB) wireless signals are transmitted together, in which the DPD has linearization bandwidth of 2.4 GHz. It is shown that the implemented DPD leads to EVM improvements of 4.5-dB (BTB) and 3.1-dB (10 km SMF) for the WiFi signal, and 4.6-dB (BTB) and 4-dB (10 km SMF) for the broadband UWB signal.

Broadband low-frequency sound isolation by lightweight adaptive metamaterials

NASA Astrophysics Data System (ADS)

Liao, Yunhong; Chen, Yangyang; Huang, Guoliang; Zhou, Xiaoming

2018-03-01

Blocking broadband low-frequency airborne noises is highly desirable in lots of engineering applications, while it is extremely difficult to be realized with lightweight materials and/or structures. Recently, a new class of lightweight adaptive metamaterials with hybrid shunting circuits has been proposed, demonstrating super broadband structure-borne bandgaps. In this study, we aim at examining their potentials in broadband sound isolation by establishing an analytical model that rigorously combines the piezoelectric dynamic couplings between adaptive metamaterials and acoustics. Sound transmission loss of the adaptive metamaterial is investigated with respect to both the frequency and angular spectrum to demonstrate their sound-insulation effects. We find that efficient sound isolation can indeed be pursued in the broadband bi-spectrum for not only the case of the small resonator's periodicity where only one mode relevant to the mass-spring resonance exists, but also for the large-periodicity scenario, so that the total weight can be even lighter, in which the multiple plate-resonator coupling modes appear. In the latter case, the negative spring stiffness provided by the piezoelectric stack has been utilized to suppress the resonance-induced high acoustic transmission. Such kinds of adaptive metamaterials could open a new approach for broadband noise isolation with extremely lightweight structures.

Sonic spectrometer and treatment system

DOEpatents

Slomka, B.J.

1997-06-03

A novel system and method is developed for treating an object with sonic waveforms. A traveling broad-band sonic waveform containing a broad-band of sonic frequencies is radiated at the object. A traveling reflected sonic waveform containing sonic frequencies reflected by the object is received in response to the traveling broad-band sonic waveform. A traveling transmitted sonic waveform containing sonic frequencies transmitted through the object is also received in response to the traveling broad-band sonic waveform. In a resonance mode, the frequency spectra of the broad-band and reflected sonic waveforms is analyzed so as to select one or more sonic frequencies that cause the object to resonate. An electrical resonance treatment sonic waveform containing the sonic frequencies that cause the object to resonate is then radiated at the object so as to treat the object. In an absorption mode, the frequency spectra of the electrical broad-band, reflected, and transmitted sonic waveforms is compared so as to select one or more sonic frequencies that are absorbed by the object. An electrical absorption treatment sonic waveform containing the sonic frequencies that are absorbed by the object is then radiated at the object so as to treat the object. 1 fig.

Sonic spectrometer and treatment system

DOEpatents

Slomka, Bogdan J.

1997-06-03

A novel system and method for treating an object with sonic waveforms. A traveling broad-band sonic waveform containing a broad-band of sonic frequencies is radiated at the object. A traveling reflected sonic waveform containing sonic frequencies reflected by the object is received in response to the traveling broad-band sonic waveform. A traveling transmitted sonic waveform containing sonic frequencies transmitted through the object is also received in response to the traveling broad-band sonic waveform. In a resonance mode, the frequency spectra of the broad-band and reflected sonic waveforms is analyzed so as to select one or more sonic frequencies that cause the object to resonate. An electrical resonance treatment sonic waveform containing the sonic frequencies that cause the object to resonate is then radiated at the object so as to treat the object. In an absorption mode, the frequency spectra of the electrical broad-band, reflected, and transmitted sonic waveforms is compared so as to select one or more sonic frequencies that are absorbed by the object. An electrical absorption treatment sonic waveform containing the sonic frequencies that are absorbed by the object is then radiated at the object so as to treat the object.

Methods and apparatus for vertical coupling from dielectric waveguides

DOEpatents

Yaacobi, Ami; Cordova, Brad Gilbert

2014-06-17

A frequency-chirped nano-antenna provides efficient sub-wavelength vertical emission from a dielectric waveguide. In one example, this nano-antenna includes a set of plasmonic dipoles on the opposite side of a SiYV.sub.4 waveguide from a ground plane. The resulting structure, which is less than half a wavelength long, emits a broadband beam (e.g., >300 nm) that can be coupled into an optical fiber. In some embodiments, a diffractive optical element with unevenly shaped regions of high- and low-index dielectric material collimates the broadband beam for higher coupling efficiency. In some cases, a negative lens element between the nano-antenna and the diffractive optical element accelerates the emitted beam's divergence (and improves coupling efficiency), allowing for more compact packaging. Like the diffractive optical element, the negative lens element includes unevenly shaped regions of high- and low-index dielectric material that can be designed to compensate for aberrations in the beam emitted by the nano-antenna.

Modeling NDT piezoelectric ultrasonic transmitters.

PubMed

San Emeterio, J L; Ramos, A; Sanz, P T; Ruíz, A; Azbaid, A

2004-04-01

Ultrasonic NDT applications are frequently based on the spike excitation of piezoelectric transducers by means of efficient pulsers which usually include a power switching device (e.g. SCR or MOS-FET) and some rectifier components. In this paper we present an approximate frequency domain electro-acoustic model for pulsed piezoelectric ultrasonic transmitters which, by integrating partial models of the different stages (driving electronics, tuning/matching networks and broadband piezoelectric transducer), allows the computation of the emission transfer function and output force temporal waveform. An approximate frequency domain model is used for the evaluation of the electrical driving pulse from the spike generator. Tuning circuits, interconnecting cable and mechanical impedance matching layers are modeled by means of transmission lines and the classical quadripole approach. The KLM model is used for the piezoelectric transducer. In addition, a PSPICE scheme is used for an alternative simulation of the broadband driving spike, including the accurate evaluation of non-linear driving effects. Several examples illustrate the capabilities of the specifically developed software.

Internet Effects in Times of Political Crisis: Online Newsgathering and Attitudes toward the European Union.

PubMed

Baccini, Leonardo; Sudulich, Laura; Wall, Matthew

2016-01-01

This paper evaluates the influence of online news consumption on attitudes toward the European Union in a context of protracted economic crisis. Using data from the 2011 Irish National Election Study, we combine location-specific information on broadband availability with respondent geo-location data, which facilitates causal inference about the effects of online news consumption via instrumental variable models. Results show that Irish citizens who source political information online are more prone to blame the EU for the poor state of the economy than those who do not. There is evidence of preference reinforcement among those with negative predispositions toward the EU, but not among pro-EU citizens. We complement this analysis with a study of voting behavior in the European Fiscal Compact Referendum, employing a similar methodological approach. The results from this second survey confirm the anti-EU influence of online news consumption among Irish citizens, although evidence suggests a pro-EU effect among voters who browsed the website of the politically neutral Irish Referendum Commission. Our paper contributes to the literature on public opinion, the EU, and political attitudes in times of crisis.

TeleMEDiana: telesurgery and telemedicine by satellite and the Internet

NASA Astrophysics Data System (ADS)

Dobrosavljevic, Sneja; Welter, Roger

2002-08-01

The rapid development of technology and its integration into the spectrum of medical care are creating a pressing need for healthcare professionals to continuously update their knowledge and skills. In view of these needs the European Association of Visceral Surgery (AECV) which had been a platform for medical congresses in Luxembourg (1988, 1992, 1995, 1998) has developed TeleMEDiana a new broadband communication service introducing standards of excellence in Continuous Medical Education.TeleMEDiana broadcast a daily program with pedagogically enhanced video content in a number of therapeutic areas to MD's, professors and students in hospitals, universities and research centers. The educational programs are provided by leading European hospitals which have joined the TeleMEDiana Scientific Network TSN. The scientific integrity is certified by an international committee composed of recognized pioneers. Committed to deliver high resolution video streaming, TeleMEDiana has set up and successfully tested a new platform built on secure and cost-efficient satellite operator SES-ASTRA complemented by the Internet and can deliver programs to any workplace equipped with satellite dishes and high-quality set-top boxes. Telemediana offers herewith an optimal collaboration and dissemination platform to decisive players involved in Continuing Medical Education.

Dynamic biophotonics: female squid exhibit sexually dimorphic tunable leucophores and iridocytes.

PubMed

DeMartini, Daniel G; Ghoshal, Amitabh; Pandolfi, Erica; Weaver, Aaron T; Baum, Mary; Morse, Daniel E

2013-10-01

Loliginid squid use tunable multilayer reflectors to modulate the optical properties of their skin for camouflage and communication. Contained inside specialized cells called iridocytes, these photonic structures have been a model for investigations into bio-inspired adaptive optics. Here, we describe two distinct sexually dimorphic tunable biophotonic features in the commercially important species Doryteuthis opalescens: bright stripes of rainbow iridescence on the mantle just beneath each fin attachment and a bright white stripe centered on the dorsal surface of the mantle between the fins. Both of these cellular features are unique to the female; positioned in the same location as the conspicuously bright white testis in the male, they are completely switchable, transitioning between transparency and high reflectivity. The sexual dimorphism, location and tunability of these features suggest that they may function in mating or reproduction. These features provide advantageous new models for investigation of adaptive biophotonics. The intensely reflective cells of the iridescent stripes provide a greater signal-to-noise ratio than the adaptive iridocytes studied thus far, while the cells constituting the white stripe are adaptive leucophores--unique biological tunable broadband scatterers containing Mie-scattering organelles activated by acetylcholine, and a unique complement of reflectin proteins.

Adding the missing piece: Spitzer imaging of the HSC-Deep/PFS fields

NASA Astrophysics Data System (ADS)

Sajina, Anna; Bezanson, Rachel; Capak, Peter; Egami, Eiichi; Fan, Xiaohui; Farrah, Duncan; Greene, Jenny; Goulding, Andy; Lacy, Mark; Lin, Yen-Ting; Liu, Xin; Marchesini, Danilo; Moutard, Thibaud; Ono, Yoshiaki; Ouchi, Masami; Sawicki, Marcin; Strauss, Michael; Surace, Jason; Whitaker, Katherine

2018-05-01

We propose to observe a total of 7sq.deg. to complete the Spitzer-IRAC coverage of the HSC-Deep survey fields. These fields are the sites of the PrimeFocusSpectrograph (PFS) galaxy evolution survey which will provide spectra of wide wavelength range and resolution for almost all M* galaxies at z 0.7-1.7, and extend out to z 7 for targeted samples. Our fields already have deep broadband and narrowband photometry in 12 bands spanning from u through K and a wealth of other ancillary data. We propose completing the matching depth IRAC observations in the extended COSMOS, ELAIS-N1 and Deep2-3 fields. By complementing existing Spitzer coverage, this program will lead to an unprecedended in spectro-photometric coverage dataset across a total of 15 sq.deg. This dataset will have significant legacy value as it samples a large enough cosmic volume to be representative of the full range of environments, but also doing so with sufficient information content per galaxy to confidently derive stellar population characteristics. This enables detailed studies of the growth and quenching of galaxies and their supermassive black holes in the context of a galaxy's local and large scale environment.

Simultaneous broadband laser ranging and photonic Doppler velocimetry for dynamic compression experiments

DOE Office of Scientific and Technical Information (OSTI.GOV)

La Lone, B. M., E-mail: lalonebm@nv.doe.gov; Marshall, B. R.; Miller, E. K.

2015-02-15

A diagnostic was developed to simultaneously measure both the distance and velocity of rapidly moving surfaces in dynamic compression experiments, specifically non-planar experiments where integrating the velocity in one direction does not always give the material position accurately. The diagnostic is constructed mainly from fiber-optic telecommunications components. The distance measurement is based on a technique described by Xia and Zhang [Opt. Express 18, 4118 (2010)], which determines the target distance every 20 ns and is independent of the target speed. We have extended the full range of the diagnostic to several centimeters to allow its use in dynamic experiments, andmore » we multiplexed it with a photonic Doppler velocimetry (PDV) system so that distance and velocity histories can be measured simultaneously using one fiber-optic probe. The diagnostic was demonstrated on a spinning square cylinder to show how integrating a PDV record can give an incorrect surface position and how the ranging diagnostic described here obtains it directly. The diagnostic was also tested on an explosive experiment where copper fragments and surface ejecta were identified in both the distance and velocity signals. We show how the distance measurements complement the velocity data. Potential applications are discussed.« less

An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure.

PubMed

Hallam, Dean; Collin, Joseph; Bojic, Sanja; Chichagova, Valeria; Buskin, Adriana; Xu, Yaobo; Lafage, Lucia; Otten, Elsje G; Anyfantis, George; Mellough, Carla; Przyborski, Stefan; Alharthi, Sameer; Korolchuk, Viktor; Lotery, Andrew; Saretzki, Gabriele; McKibbin, Martin; Armstrong, Lyle; Steel, David; Kavanagh, David; Lako, Majlinda

2017-11-01

Age-related macular degeneration (AMD) is the most common cause of blindness, accounting for 8.7% of all blindness globally. Vision loss is caused ultimately by apoptosis of the retinal pigment epithelium (RPE) and overlying photoreceptors. Treatments are evolving for the wet form of the disease; however, these do not exist for the dry form. Complement factor H polymorphism in exon 9 (Y402H) has shown a strong association with susceptibility to AMD resulting in complement activation, recruitment of phagocytes, RPE damage, and visual decline. We have derived and characterized induced pluripotent stem cell (iPSC) lines from two subjects without AMD and low-risk genotype and two patients with advanced AMD and high-risk genotype and generated RPE cells that show local secretion of several proteins involved in the complement pathway including factor H, factor I, and factor H-like protein 1. The iPSC RPE cells derived from high-risk patients mimic several key features of AMD including increased inflammation and cellular stress, accumulation of lipid droplets, impaired autophagy, and deposition of "drüsen"-like deposits. The low- and high-risk RPE cells respond differently to intermittent exposure to UV light, which leads to an improvement in cellular and functional phenotype only in the high-risk AMD-RPE cells. Taken together, our data indicate that the patient specific iPSC model provides a robust platform for understanding the role of complement activation in AMD, evaluating new therapies based on complement modulation and drug testing. Stem Cells 2017;35:2305-2320. © 2017 The Authors Stem Cells published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.

Coupling complement regulators to immunoglobulin domains generates effective anti-complement reagents with extended half-life in vivo

PubMed Central

HARRIS, C L; WILLIAMS, A S; LINTON, S M; MORGAN, B P

2002-01-01

Complement activation and subsequent generation of inflammatory molecules and membrane attack complex contributes to the pathology of a number of inflammatory and degenerative diseases, including arthritis, glomerulonephritis and demyelination. Agents that specifically inhibit complement activation might prove beneficial in the treatment of these diseases. Soluble recombinant forms of the naturally occurring membrane complement regulatory proteins (CRP) have been exploited for this purpose. We have undertaken to design better therapeutics based on CRP. Here we describe the generation of soluble, recombinant CRP comprising rat decay accelerating factor (DAF) or rat CD59 expressed as Fc fusion proteins, antibody-like molecules comprising two CRP moieties in place of the antibody Fab arms (CRP-Ig). Reagents bearing DAF on each arm (DAF-Ig), CD59 on each arm (CD59-Ig) and a hybrid reagent containing both DAF and CD59 were generated. All three reagents inhibited C activation in vitro. Compared with soluble CRP lacking Fc domains, activity was reduced, but was fully restored by enzymatic release of the regulator from the Ig moiety, implicating steric constraints in reducing functional activity. In vivo studies showed that DAF-Ig, when compared to soluble DAF, had a much extended half-life in the circulation in rats and concomitantly caused a sustained reduction in plasma complement activity. When given intra-articularly to rats in a model of arthritis, DAF-Ig significantly reduced severity of disease. The data demonstrate the potential of CRP-Ig as reagents for sustained therapy of inflammatory disorders, including arthritis, but emphasize the need for careful design of fusion proteins to retain function. PMID:12165074

Complement inhibition decreases early fibrogenic events in the lung of septic baboons.

PubMed

Silasi-Mansat, Robert; Zhu, Hua; Georgescu, Constantin; Popescu, Narcis; Keshari, Ravi S; Peer, Glenn; Lupu, Cristina; Taylor, Fletcher B; Pereira, Heloise Anne; Kinasewitz, Gary; Lambris, John D; Lupu, Florea

2015-11-01

Acute respiratory distress syndrome (ARDS) induced by severe sepsis can trigger persistent inflammation and fibrosis. We have shown that experimental sepsis in baboons recapitulates ARDS progression in humans, including chronic inflammation and long-lasting fibrosis in the lung. Complement activation products may contribute to the fibroproliferative response, suggesting that complement inhibitors are potential therapeutic agents. We have been suggested that treatment of septic baboons with compstatin, a C3 convertase inhibitor protects against ARDS-induced fibroproliferation. Baboons challenged with 10(9) cfu/kg (LD50) live E. coli by intravenous infusion were treated or not with compstatin at the time of challenge or 5 hrs thereafter. Changes in the fibroproliferative response at 24 hrs post-challenge were analysed at both transcript and protein levels. Gene expression analysis showed that sepsis induced fibrotic responses in the lung as early as 24 hrs post-bacterial challenge. Immunochemical and biochemical analysis revealed enhanced collagen synthesis, induction of profibrotic factors and increased cell recruitment and proliferation. Specific inhibition of complement with compstatin down-regulated sepsis-induced fibrosis genes, including transforming growth factor-beta (TGF-β), connective tissue growth factor (CTGF), tissue inhibitor of metalloproteinase 1 (TIMP1), various collagens and chemokines responsible for fibrocyte recruitment (e.g. chemokine (C-C motif) ligand 2 (CCL2) and 12 (CCL12)). Compstatin decreased the accumulation of myofibroblasts and proliferating cells, reduced the production of fibrosis mediators (TGF-β, phospho-Smad-2 and CTGF) and inhibited collagen deposition. Our data demonstrate that complement inhibition effectively attenuates collagen deposition and fibrotic responses in the lung after severe sepsis. Inhibiting complement could prove an attractive strategy for preventing sepsis-induced fibrosis of the lung. © 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

Analysis of volcano-related seismicity to constrain the magmatic plumbing system beneath Fogo, Cape Verde, by (multi-)array techniques

NASA Astrophysics Data System (ADS)

Dietrich, Carola; Wölbern, Ingo; Faria, Bruno; Rümpker, Georg

2017-04-01

Fogo is the only island of the Cape Verde archipelago with regular occurring volcanic eruptions since its discovery in the 15th century. The volcanism of the archipelago originates from a mantle plume beneath an almost stationary tectonic plate. With an eruption interval of approximately 20 years, Fogo belongs to the most active oceanic volcanoes. The latest eruption started in November 2014 and ceased in February 2015. This study aims to characterize and investigate the seismic activity and the magmatic plumbing system of Fogo, which is believed to be related to a magmatic source close to the neighboring island of Brava. According to previous studies, using conventional seismic network configurations, most of the seismic activity occurs offshore. Therefore, seismological array techniques represent powerful tools in investigating earthquakes and other volcano-related events located outside of the networks. Another advantage in the use of seismic arrays is their possibility to detect events of relatively small magnitude and to locate seismic signals without a clear onset of phases, such as volcanic tremors. Since October 2015 we have been operating a test array on Fogo as part of a pilot study. This array consists of 10 seismic stations, distributed in a circular shape with an aperture of 700 m. The stations are equipped with Omnirecs CUBE dataloggers, and either 4.5 Hz geophones (7 stations) or Trillium-Compact broad-band seismometers (3 stations). In January 2016 we installed three additional broad-band stations distributed across the island of Fogo to improve the capabilities for event localization. The data of the pilot study is dominated by seismic activity around Brava, but also exhibit tremors and hybrid events of unknown origin within the caldera of Fogo volcano. The preliminary analysis of these events includes the characterization and localization of the different event types using seismic array processing in combination with conventional localization methods. In the beginning of August 2016, a "seismic crisis" occurred on the island of Brava which led to the evacuation of a village. The seismic activity recorded by our instruments on Fogo exhibits more than 40 earthquakes during this time. Locations and magnitudes of these events will be presented. In January 2017 the pilot project discussed here will be complemented by three additional seismic arrays (two on Fogo, one on Brava) to improve seismic event localization and structural imaging based on scattered seismic phases by using multi-array techniques. Initial recordings from the new arrays are expected to be available by April 2017.

Complementing the Australian Primary School Health and Physical Education (HPE) Curriculum: Exploring Children's HPE Learning Experiences within Varying School Ground Equipment Contexts

ERIC Educational Resources Information Center

Hyndman, Brendon; Mahony, Linda; Te Ava, Aue; Smith, Sue; Nutton, Georgie

2017-01-01

This paper unearths how primary school children experience and can complement the Australian HPE curriculum within three unique school ground equipment scenarios that include an "empty", "loose parts" and a "traditional" school ground context. Using direct observation, 490 scans were undertaken of the school grounds…

FAST copper for broadband access

NASA Astrophysics Data System (ADS)

Chiang, Mung; Huang, Jianwei; Cendrillon, Raphael; Tan, Chee Wei; Xu, Dahai

2006-10-01

FAST Copper is a multi-year, U.S. NSF funded project that started in 2004, and is jointly pursued by the research groups of Mung Chiang at Princeton University, John Cioffi at Stanford University, and Alexader Fraser at Fraser Research Lab, and in collaboration with several industrial partners including AT&T. The goal of the FAST Copper Project is to provide ubiquitous, 100 Mbps, fiber/DSL broadband access to everyone in the U.S. with a phone line. This goal will be achieved through two threads of research: dynamic and joint optimization of resources in Frequency, Amplitude, Space, and Time (thus the name 'FAST') to overcome the attenuation and crosstalk bottlenecks, and the integration of communication, networking, computation, modeling, and distributed information management and control for the multi-user twisted pair network.

Chacterization of Teleseismic Earthquakes Observed on an Ice Shelf

NASA Astrophysics Data System (ADS)

Baker, M. G.; Aster, R. C.; Anthony, R. E.; Wiens, D.; Nyblade, A.; Bromirski, P. D.; Stephen, R. A.; Gerstoft, P.

2016-12-01

Broadband seismographs deployed atop large tabular icebergs and ice shelves record a rich superposition of atmospheric, oceanic, and solid earth signals. We characterize these signals, including body and surface wave arrivals from approximately 200 global earthquakes, using a 34-station broadband array spanning the Ross Ice Shelf, Antarctica. Teleseismic earthquake arrivals are essential for constructing models of crustal and upper mantle structure, and observations on the ice shelf are key to resolving the structure of the underlying West Antarctic Rift System. To test the plausibility of passive imaging in this unique environment, we examine seasonal and spatial dependence of signal-to-noise ratios of body wave arrivals and the impact of ice shelf dynamics on surface wave dispersion. We also note unusual phase mechanics arising from the floating platform geometry.

Investigation of the validity of quasilinear theory for electron Landau damping in a tokamak using a broad-band wave effect

DOE PAGES

Lee, Jungpyo; Bonoli, Paul; Wright, John

2011-01-01

The quasilinear diffusion coefficient assuming a constant magnetic field along the electron orbit is widely used to describe electron Landau damping of waves in a tokamak where the magnitude of the magnetic field varies on a flux surface. To understand the impact of violating the constant magnetic field assumption, we introduce the effect of a broad-bandwidth wave spectrum which has been used in the past to validate quasilinear theory for the fast decorrelation process between resonances. By the reevaluation of the diffusion coefficient through the level of the phase integral for the tokamak geometry with the broad-band wave effect included,more » we identify the three acceptable errors for the use of the quasilinear diffusion coefficient.« less

Modal expansions for infrasound propagation and their implications for ground-to-ground propagation.

PubMed

Waxler, Roger; Assink, Jelle; Velea, Doru

2017-02-01

The use of expansions in vertical eigenmodes for long range infrasound propagation modeling in the effective sound speed approximation is investigated. The question of convergence of such expansions is related to the maximum elevation angles that are required. Including atmospheric attenuation leads to a non-self-adjoint vertical eigenvalue problem. The use of leading order perturbation theory for the modal attenuation is compared to the results of numerical solutions to the non-self-adjoint eigenvalue problem and conditions under which the perturbative result is expected to be valid are obtained. Modal expansions are obtained in the frequency domain; broadband signals must be modeled through Fourier reconstruction. Such broadband signal reconstruction is investigated and the relation between bandwidth, wavetrain duration, and frequency sampling is discussed.

Optimal design of similariton fiber lasers without gain-bandwidth limitation.

PubMed

Li, Xingliang; Zhang, Shumin; Yang, Zhenjun

2017-07-24

We have numerically investigated broadband high-energy similariton fiber lasers, demonstrated that the self-similar evolution of pulses can locate in a segment of photonic crystal fiber without gain-bandwidth limitation. The effects of various parameters, including the cavity length, the spectral filter bandwidth, the pump power, the length of the photonic crystal fiber and the output coupling ratio have also been studied in detail. Using the optimal parameters, a single pulse with spectral width of 186.6 nm, pulse energy of 23.8 nJ, dechirped pulse duration of 22.5 fs and dechirped pulse peak power of 1.26 MW was obtained. We believe that this detailed analysis of the behaviour of pulses in the similariton regime may have major implications in the development of broadband high-energy fiber lasers.

The Evolution of the Policy Objectives of South Korea's Broadband Convergence Network from 2004 to 2007

ERIC Educational Resources Information Center

Menon, Siddhartha

2011-01-01

The purpose of this study is to explore the South Korean government's policy objectives for the Broadband Convergence Network (BcN) between 2004 and 2007. The BcN is envisioned as conduit for broadband content and applications. This paper uses generativity as a conceptual framework to determine whether the objectives for the BcN, based on a…

Broadband and High power Reactive Jamming Resilient Wireless Communication

DTIC Science & Technology

2017-10-21

Broadband and High -power Reactive Jamming Resilient Wireless Communication The views, opinions and/or findings contained in this report are those of... available in extremely hostile environments, where FHSS and DSSS are completely defeated by a broadband and high -power reactive jammer. b. Wireless...SECURITY CLASSIFICATION OF: 1. REPORT DATE (DD-MM-YYYY) 4. TITLE AND SUBTITLE 13. SUPPLEMENTARY NOTES 12. DISTRIBUTION AVAILIBILITY STATEMENT 6. AUTHORS

Advanced Telecommunications in Rural America: The Challenge of Bringing Broadband Service to All Americans.

ERIC Educational Resources Information Center

National Telecommunications and Information Administration (DOC), Washington, DC.

This report, in response to a request by 10 U.S. Senators examines the status of broadband deployment in the United States. The rate of deployment of broadband services will be key to future economic growth, particularly in rural areas far from urban and world markets. This report finds that rural areas, especially remote areas outside of towns,…

Telecommunications Policy Research Conference. Future of the Telecommunications Network Section. Papers.

ERIC Educational Resources Information Center

Telecommunications Policy Research Conference, Inc., Washington, DC.

The paper for which an abstract is presented here, "Future Network Architectures" (Anthony Rutowski), discussed innovations in processing/switching and transmission technologies, including the development of new broadband optical transfer modes using label and position multiplexing techniques. It is suggested that future network…

Network Policy and Economic Doctrines

ERIC Educational Resources Information Center

Atkinson, Robert D.

2010-01-01

For many years, debates over telecommunications network policy were marked by a relative lack of partisan and ideological conflict. In the last decade, this has changed markedly. Today, debates over a whole set of issues, including broadband competition, net neutrality, copyright, privacy, and others, have become more contentious. These…

75 FR 26958 - Public Information Collections Approved by The Office of Management and Budget (OMB)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-13

.../29/2010. OMB Expiration Date: 09/30/2010. Title: Spectrum Dashboard Customer Feedback. Form No.: N/A... uses, including nationwide broadband deployment. The Commission will use the Spectrum Dashboard... the Spectrum Dashboard (e.g., individuals, licensees, manufacturers, entrepreneurs, industry analysts...

Signal Processing Methods for Liquid Rocket Engine Combustion Stability Assessments

NASA Technical Reports Server (NTRS)

Kenny, R. Jeremy; Lee, Erik; Hulka, James R.; Casiano, Matthew

2011-01-01

The J2X Gas Generator engine design specifications include dynamic, spontaneous, and broadband combustion stability requirements. These requirements are verified empirically based high frequency chamber pressure measurements and analyses. Dynamic stability is determined with the dynamic pressure response due to an artificial perturbation of the combustion chamber pressure (bomb testing), and spontaneous and broadband stability are determined from the dynamic pressure responses during steady operation starting at specified power levels. J2X Workhorse Gas Generator testing included bomb tests with multiple hardware configurations and operating conditions, including a configuration used explicitly for engine verification test series. This work covers signal processing techniques developed at Marshall Space Flight Center (MSFC) to help assess engine design stability requirements. Dynamic stability assessments were performed following both the CPIA 655 guidelines and a MSFC in-house developed statistical-based approach. The statistical approach was developed to better verify when the dynamic pressure amplitudes corresponding to a particular frequency returned back to pre-bomb characteristics. This was accomplished by first determining the statistical characteristics of the pre-bomb dynamic levels. The pre-bomb statistical characterization provided 95% coverage bounds; these bounds were used as a quantitative measure to determine when the post-bomb signal returned to pre-bomb conditions. The time for post-bomb levels to acceptably return to pre-bomb levels was compared to the dominant frequency-dependent time recommended by CPIA 655. Results for multiple test configurations, including stable and unstable configurations, were reviewed. Spontaneous stability was assessed using two processes: 1) characterization of the ratio of the peak response amplitudes to the excited chamber acoustic mode amplitudes and 2) characterization of the variability of the peak response's frequency over the test duration. This characterization process assists in evaluating the discreteness of a signal as well as the stability of the chamber response. Broadband stability was assessed using a running root-mean-square evaluation. These techniques were also employed, in a comparative analysis, on available Fastrac data, and these results are presented here.

Broadband, Common-path, Interferometric Wavefront Sensor

NASA Technical Reports Server (NTRS)

Wallace, James Kent (Inventor)

2015-01-01

Hybrid sensors comprising Shack-Hartmann Wavefront Sensor (S-HWFS) and Zernike Wavefront Sensor (Z-WFS) capabilities are presented. The hybrid sensor includes a Z-WFS optically arranged in-line with a S-HWFS such that the combined wavefront sensor operates across a wide dynamic range and noise conditions. The Z-WFS may include the ability to introduce a dynamic phase shift in both transmissive and reflective modes.

Why Broadband Internet Should Not Be the Priority for Developing Countries

NASA Astrophysics Data System (ADS)

Noam, Eli

With broadband Internet connectivity progressing, the focus of attention has shifted to those left behind. The shorthand word for this concern is the classic “digital divide.” Underlying virtually every discussion about a gap in broadband penetrations is the implicit assumption that overcoming such a divide is a priority (Meschi et al., 2004; Crandall et al., 2007). But maybe we first should pause for a moment and understand the implications of ending this divide. If we do that, we might end up changing our perspective on Internet policy in an important way: away from a focus on broadband Internet connectivity, and towards universal connectivity and the creation of E-transactions, E-commerce, and E-content.

A Theoretical Basis for the Scaling Law of Broadband Shock Noise Intensity in Supersonic Jets

NASA Technical Reports Server (NTRS)

Kandula, Max

2011-01-01

A theoretical basis for the scaling of broadband shock noise intensity In supersonic jets was formulated considering linear shock-shear wave interaction. Modeling of broadband shock noise with the aid of shock-turbulence interaction with special reference to linear theories is briefly reviewed. An hypothesis has been postulated that the peak angle of incidence (closer to the critical angle) for the shear wave primarily governs the generation of sound in the interaction process with the noise generation contribution from off-peak incident angles being relatively unimportant. The proposed hypothesis satisfactorily explains the well-known scaling law for the broadband shock-associated noise in supersonic jets.

Broadband infrared absorbers with stacked double chromium ring resonators

DOE PAGES

Deng, Huixu; Stan, Liliana; Czaplewski, David A.; ...

2017-10-31

A broadband absorber in the infrared wavelength range from 1 μm up to 5 μm is designed and demonstrated with stacked double chromium ring resonators on a reflective chromium mirror. The near-perfect broadband absorption is realized by combining the multilayer impedance match in the short wavelength range and the double plasmonic resonances in the long wavelength range, which is illustrated with an equivalent circuit model for the impedance analysis. The broadband absorber is proved to be angle-insensitive and polarization-independent due to the geometrical symmetry. Lastly, the thermal analysis for heat generation and temperature distributions inside the absorber structure is alsomore » investigated.« less

Broadband wavelength conversion in hydrogenated amorphous silicon waveguide with silicon nitride layer

NASA Astrophysics Data System (ADS)

Wang, Jiang; Li, Yongfang; Wang, Zhaolu; Han, Jing; Huang, Nan; Liu, Hongjun

2018-01-01

Broadband wavelength conversion based on degenerate four-wave mixing is theoretically investigated in a hydrogenated amorphous silicon (a-Si:H) waveguide with silicon nitride inter-cladding layer (a-Si:HN). We have found that enhancement of the non-linear effect of a-Si:H waveguide nitride intermediate layer facilitates broadband wavelength conversion. Conversion bandwidth of 490 nm and conversion efficiency of 11.4 dB were achieved in a numerical simulation of a 4 mm-long a-Si:HN waveguide under 1.55 μm continuous wave pumping. This broadband continuous-wave wavelength converter has potential applications in photonic networks, a type of readily manufactured low-cost highly integrated optical circuits.

Nonphasematched broadband THz amplification and reshaping in a dispersive chi(3) medium.

PubMed

Koys, Martin; Noskovicova, Eva; Velic, Dusan; Lorenc, Dusan

2017-06-12

We theoretically investigate non-phasematched broadband THz amplification in dispersive chi(3) media. A short 100 fs pump pulse is interacting with a temporally matched second harmonic pulse and a weak THz signal through the four wave mixing process and a significant broadband THz amplification and reshaping is observed. The pulse evolution dynamics is explored by numerically solving a set of generalized Nonlinear Schroedinger equations. The influence of incident pulse chirp, pulse duration and the role of wavelength, THz seed frequency and losses are evaluated separately. It is found that a careful choice of incident parameters can provide a broadband THz output and/or a significant increase of THz peak power.

Non-Foster Circuits for High Performance Antennas: Advantages and Practical Limitations

NASA Astrophysics Data System (ADS)

Jacob, Minu Mariam

The demand for miniaturized, broadband communication systems has created a need for electrically small, broadband antennas. However, all passive electrically small antennas have a fundamental gain-bandwidth limitation related to their electrical size, as first described by Wheeler and Chu. This limitation can be overcome using active non-Foster circuits (negative inductors and/or negative capacitors), which can deliver a broadband input match with active matching techniques, or can help reduce phase dispersion using negative delay effects. This thesis will illustrate the advantages of non-Foster circuits in obtaining broadband small antennas, in addition to examining their practical limitations due to noise in receive applications, and nonlinearity in transmit applications.

Broadband infrared absorbers with stacked double chromium ring resonators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deng, Huixu; Stan, Liliana; Czaplewski, David A.

A broadband absorber in the infrared wavelength range from 1 μm up to 5 μm is designed and demonstrated with stacked double chromium ring resonators on a reflective chromium mirror. The near-perfect broadband absorption is realized by combining the multilayer impedance match in the short wavelength range and the double plasmonic resonances in the long wavelength range, which is illustrated with an equivalent circuit model for the impedance analysis. The broadband absorber is proved to be angle-insensitive and polarization-independent due to the geometrical symmetry. Lastly, the thermal analysis for heat generation and temperature distributions inside the absorber structure is alsomore » investigated.« less

Standardization of Broadband UV Measurements for 365 nm LED Sources

PubMed Central

Eppeldauer, George P.

2012-01-01

Broadband UV measurements are evaluated when UV-A irradiance meters measure optical radiation from 365 nm UV sources. The CIE standardized rectangular-shape UV-A function can be realized only with large spectral mismatch errors. The spectral power-distribution of the 365 nm excitation source is not standardized. Accordingly, the readings made with different types of UV meters, even if they measure the same UV source, can be very different. Available UV detectors and UV meters were measured and evaluated for spectral responsivity. The spectral product of the source-distribution and the meter’s spectral-responsivity were calculated for different combinations to estimate broad-band signal-measurement errors. Standardization of both the UV source-distribution and the meter spectral-responsivity is recommended here to perform uniform broad-band measurements with low uncertainty. It is shown what spectral responsivity function(s) is needed for new and existing UV irradiance meters to perform low-uncertainty broadband 365 nm measurements. PMID:26900516

A complementation assay for in vivo protein structure/function analysis in Physcomitrella patens (Funariaceae)

DOE PAGES

Scavuzzo-Duggan, Tess R.; Chaves, Arielle M.; Roberts, Alison W.

2015-07-14

Here, a method for rapid in vivo functional analysis of engineered proteins was developed using Physcomitrella patens. A complementation assay was designed for testing structure/function relationships in cellulose synthase (CESA) proteins. The components of the assay include (1) construction of test vectors that drive expression of epitope-tagged PpCESA5 carrying engineered mutations, (2) transformation of a ppcesa5 knockout line that fails to produce gametophores with test and control vectors, (3) scoring the stable transformants for gametophore production, (4) statistical analysis comparing complementation rates for test vectors to positive and negative control vectors, and (5) analysis of transgenic protein expression by Westernmore » blotting. The assay distinguished mutations that generate fully functional, nonfunctional, and partially functional proteins. In conclusion, compared with existing methods for in vivo testing of protein function, this complementation assay provides a rapid method for investigating protein structure/function relationships in plants.« less

Broadband Circularly Polarized Patch Antenna and Method

DTIC Science & Technology

2016-09-16

300152 1 of 14 BROADBAND CIRCULARLY POLARIZED PATCH ANTENNA AND METHOD STATEMENT OF GOVERNMENT INTEREST [0001] The invention described herein may...present invention provides a method and apparatus for a broadband circularly polarized patch antenna . (2) Description of the Prior Art [0004] A...patch antenna , also referred to as a microstrip antenna , is a type of radio antenna with a low profile that can be mounted on a flat surface. The

Development of an Autonomous Broadband Acoustic Scattering System for Remote Characterization of Zooplankton

DTIC Science & Technology

2008-01-01

backscatter at a single narrowband frequency, and some AUVs carry single-frequency sidescan sonars (and this technology has been adapted for gliders), the...broadband acoustic scattering system by adapting existing technology that has been recently developed at WHOI for a monostatic Doppler sonar module...broadband acoustic backscattering system: 1) Modifications to the monostatic Doppler sonar module, recently developed at WHOI for turbulence studies

Broadband Impedance Microscopy for Research on Complex Quantum Materials

DTIC Science & Technology

2016-02-08

function in various materials. Figure 2. Sensitivity limit of the broadband impedance microscope (BIM). Figure 3. Preliminary BIM data on YMnO3...2 Statement of the Problem The objective of this DURIP award is to construct a broadband impedance microscope (BIM) for frequency-dependent...platforms and specialized cantilever probes [1] in the PI’s lab, the BIM can now simultaneously obtain microscopic (10 – 100 nm) and quasi- spectroscopic

A photo-excited broadband to dual-band tunable terahertz prefect metamaterial polarization converter

NASA Astrophysics Data System (ADS)

Zhu, Jianfeng; Yang, Yang; Li, Shufang

2018-04-01

A new and simple design of photo-excited broadband to dual-band tunable terahertz (THz) metamaterial cross polarization converter is proposed in this paper. The tunable converter is a sandwich structure with the center-cut cross-shaped metallic patterned structure as a resonator, the middle dielectric layer as a spacer and the bottom metallic film as the ground. The conductivity of the photoconductive semiconductor (Silicon) filled in the gap of the cross-shaped metallic resonator can be tuned by the incident pump power, leading to an easy modulation of the electromagnetic response of the proposed converter. The results show that the proposed cross-polarization converter can be tuned from a broadband with polarization conversion ratio (PCR) beyond 95% (1.86-2.94 THz) to dual frequency bands (fl = 1 . 46 THz &fh = 2 . 9 THz). The conversion peaks can reach 99.9% for the broadband and, 99.5% (fl) and 99.7% (fh) for the dual-band, respectively. Most importantly, numerical simulations demonstrate that the broadband/dual-band polarization conversion mechanism of the converter originates from the localized surface plasmon modes, which make the design simple and different from previous designs. With these good features, the proposed broadband to dual-band tunable polarization converter is expected to be used in widespread applications.

A comprehensive strategy for the subtyping of patients with Fanconi anaemia: conclusions from the Spanish Fanconi Anemia Research Network

PubMed Central

Casado, José Antonio; Callén, Elsa; Jacome, Ariana; Río, Paula; Castella, Maria; Lobitz, Stephan; Ferro, Teresa; Muñoz, Arturo; Sevilla, Julián; Cantalejo, Ángeles; Cela, Elena; Cervera, José; Sánchez‐Calero, Jesús; Badell, Isabel; Estella, Jesús; Dasí, Ángeles; Olivé, Teresa; Ortega, Juan José; Rodriguez‐Villa, Antonia; Tapia, María; Molinés, Antonio; Madero, Luis; Segovia, José C; Neveling, Kornelia; Kalb, Reinhard; Schindler, Detlev; Hanenberg, Helmut; Surrallés, Jordi; Bueren, Juan A

2007-01-01

Background Fanconi anaemia is a heterogeneous genetic disease, where 12 complementation groups have been already described. Identifying the complementation group in patients with Fanconi anaemia constitutes a direct procedure to confirm the diagnosis of the disease and is required for the recruitment of these patients in gene therapy trials. Objective To determine the subtype of Fanconi anaemia patients in Spain, a Mediterranean country with a relatively high population (23%) of Fanconi anaemia patients belonging to the gypsy race. Methods Most patients could be subtyped by retroviral complementation approaches in peripheral blood T cells, although some mosaic patients were subtyped in cultured skin fibroblasts. Other approaches, mainly based on western blot analysis and generation of nuclear RAD51 and FANCJ foci, were required for the subtyping of a minor number of patients. Results and conclusions From a total of 125 patients included in the Registry of Fanconi Anaemia, samples from 102 patients were available for subtyping analyses. In 89 cases the subtype could be determined and in 8 cases exclusions of common complementation groups were made. Compared with other international studies, a skewed distribution of complementation groups was observed in Spain, where 80% of the families belonged to the Fanconi anaemia group A (FA‐A) complementation group. The high proportion of gypsy patients, all of them FA‐A, and the absence of patients with FA‐C account for this characteristic distribution of complementation groups. PMID:17105750

Invited Article: An active terahertz polarization converter employing vanadium dioxide and a metal wire grating in total internal reflection geometry

NASA Astrophysics Data System (ADS)

Liu, Xudong; Chen, Xuequan; Parrott, Edward P. J.; Han, Chunrui; Humbert, Georges; Crunteanu, Aurelian; Pickwell-MacPherson, Emma

2018-05-01

Active broadband terahertz (THz) polarization manipulation devices are challenging to realize, but also of great demand in broadband terahertz systems. Vanadium dioxide (VO2) shows a promising phase transition for active control of THz waves and provides broadband polarization characteristics when integrated within grating-type structures. We creatively combine a VO2-based grating structure with a total internal reflection (TIR) geometry providing a novel interaction mechanism between the electromagnetic waves and the device, to realize a powerful active broadband THz polarization-controlling device. The device is based on a Si-substrate coated with a VO2 layer and a metal grating structure on top, attached to a prism for generating the TIR condition on the Si-VO2-grating interface. The grating is connected to electrodes for electrically switching the VO2 between its insulating and conducting phases. By properly selecting the incident angle of the THz waves, the grating direction, and the incident polarization state, we first achieved a broadband intensity modulator under a fused silica prism with an average modulation depth of 99.75% in the 0.2-1.1 THz region. Additionally, we realized an active ultra-broadband quarter-wave converter under a Si prism that can be switched between a 45° linear rotator and a quarter wave converter in the 0.8-1.5 THz region. This is the first demonstration of an active quarter-wave converter with ultra-broad bandwidth performance. Our work shows a highly flexible and multifunctional polarization-controlling device for broadband THz applications.

Turbulence Measurements and Computations for the Predication of Broadband Noise in High Bypass Ratio Fans

NASA Technical Reports Server (NTRS)

Devenport, William J.; Ragab, Saad A.

2000-01-01

Work was performed under this grant with a view to providing the experimental and computational results needed to improve the prediction of broadband stator noise in large bypass ratio aircraft engines. The central hypothesis of our study was that a large fraction of this noise was generated by the fan tip leakage vortices. More specifically, that these vortices are a significant component of the fan wake turbulence and they contain turbulent eddies of a type that can produce significant broadband noise. To test this hypothesis we originally proposed experimental work and computations with the following objectives: (1) to build a large scale two-dimensional cascade with a tip gap and a stationary endwall that, as far as possible, simulates the fan tip geometry, (2) to build a moving endwall for use with the large scale cascade, (3) to measure, in detail, the turbulence structure and spectrum generated by the blade wake and tip leakage vortex, for both endwall configurations, (4) to use the CFD to compute the flow and turbulence distributions for both the experimental configurations and the ADP fan, (5) to provide the experimental and CFD results for the cascades and the physical understanding gained from their study as a basis for improving the broadband noise prediction method. In large part these objectives have been achieved. The most important achievements and findings of our experimental and computational efforts are summarized below. The bibliography at the end of this report includes a list of all publications produced to date under this project. Note that this list is necessarily incomplete the task of publication (particularly in journal papers) continues.

Acoustic Environment of Admiralty Inlet: Broadband Noise Measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu, Jinshan; Deng, Zhiqun; Martinez, Jayson J.

2011-09-30

Admiralty Inlet has been selected as a potential tidal energy site. It is located near shipping lanes, is a highly variable acoustic environment, and is frequented by the highly endangered southern resident killer whale (SRKW). Resolving environmental impacts is the first step to receiving approval to deploy tidal turbines at Admiralty Inlet. Of particular concern is the potential for blade strike or other negative interactions between the SRKW and the tidal turbine. A variety of technologies including passive and active monitoring systems are being considered as potential tools to determine the presence of SRKW in the vicinity of the turbines.more » Broadband noise level measurements are critical for the determination of design and operation specifications of all marine and hydrokinetic energy capture technologies. Acoustic environment data at the proposed site was acquired at different depths using a cabled vertical line array (VLA) with four calibrated hydrophones. The sound pressure level (SPL) power spectrum density was estimated based on the fast Fourier transform. This study describes the first broadband SPL measurements for this site at different depths with frequency ranging from 10 kHz to 480 kHz in combination with other information. To understand the SPL caused by this bedload transport, three different pressure sensors with temperature and conductivity were also assembled on the VLA to measure the conditions at the hydrophone deployment depth. The broadband SPL levels at frequency ranges of 3 kHz to 7 kHz as a function of depth were estimated. Only the hydrophone at an average depth of 40 m showed the strong dependence of SPL with distance from the bottom, which was possibly caused by the cobbles shifting on the seabed. Automatic Identification System data were also studied to understand the SPL measurements.« less

Telehealth on advanced networks.

PubMed

Wilson, Laurence S; Stevenson, Duncan R; Cregan, Patrick

2010-01-01

We address advanced Internet for complex telehealth applications by reviewing four hospital-based broadband telehealth projects and identifying common threads. These projects were conducted in Australia under a 6-year research project on broadband Internet applications. Each project addressed specific clinical needs and its development was guided by the clinicians involved. Each project was trialed in the field and evaluated against the initial requirements. The four projects covered remote management of a resuscitation team in a district hospital, remote guidance and interpretation of echocardiography, virtual-reality-based instructor-student surgical training, and postoperative outpatient consultations following pediatric surgery. Each was characterized by a high level of interpersonal communication, a high level of clinical expertise, and multiple participants. Each made use of multiple high-quality video and audio links and shared real-time access to clinical data. Four common threads were observed. Each application provided a high level of usability and task focus because the design and use of broadband capability was aimed directly to meet the clinicians' needs. Each used the media quality available over broadband to convey words, gestures, body movements, and facial expressions to support communication and a sense of presence among the participants. Each required a complex information space shared among the participants, including real-time access to stored patient data and real-time interactive access to the patients themselves. Finally, each application supported the social and organizational aspects of their healthcare focus, creating and maintaining relationships between the various participants, and this was done by placing the telehealth application into a wider functioning clinical context. These findings provide evidence for a significantly enhanced role for appropriate telemedicine systems running on advanced networks, in a wider range of clinical applications, more deeply integrated into healthcare systems.

The SCEC Broadband Platform: Open-Source Software for Strong Ground Motion Simulation and Validation

NASA Astrophysics Data System (ADS)

Goulet, C.; Silva, F.; Maechling, P. J.; Callaghan, S.; Jordan, T. H.

2015-12-01

The Southern California Earthquake Center (SCEC) Broadband Platform (BBP) is a carefully integrated collection of open-source scientific software programs that can simulate broadband (0-100Hz) ground motions for earthquakes at regional scales. The BBP scientific software modules implement kinematic rupture generation, low and high-frequency seismogram synthesis using wave propagation through 1D layered velocity structures, seismogram ground motion amplitude calculations, and goodness of fit measurements. These modules are integrated into a software system that provides user-defined, repeatable, calculation of ground motion seismograms, using multiple alternative ground motion simulation methods, and software utilities that can generate plots, charts, and maps. The BBP has been developed over the last five years in a collaborative scientific, engineering, and software development project involving geoscientists, earthquake engineers, graduate students, and SCEC scientific software developers. The BBP can run earthquake rupture and wave propagation modeling software to simulate ground motions for well-observed historical earthquakes and to quantify how well the simulated broadband seismograms match the observed seismograms. The BBP can also run simulations for hypothetical earthquakes. In this case, users input an earthquake location and magnitude description, a list of station locations, and a 1D velocity model for the region of interest, and the BBP software then calculates ground motions for the specified stations. The SCEC BBP software released in 2015 can be compiled and run on recent Linux systems with GNU compilers. It includes 5 simulation methods, 7 simulation regions covering California, Japan, and Eastern North America, the ability to compare simulation results against GMPEs, updated ground motion simulation methods, and a simplified command line user interface.

Intracranial spectral amplitude dynamics of perceptual suppression in fronto-insular, occipito-temporal, and primary visual cortex

PubMed Central

Vidal, Juan R.; Perrone-Bertolotti, Marcela; Kahane, Philippe; Lachaux, Jean-Philippe

2015-01-01

If conscious perception requires global information integration across active distant brain networks, how does the loss of conscious perception affect neural processing in these distant networks? Pioneering studies on perceptual suppression (PS) described specific local neural network responses in primary visual cortex, thalamus and lateral prefrontal cortex of the macaque brain. Yet the neural effects of PS have rarely been studied with intracerebral recordings outside these cortices and simultaneously across distant brain areas. Here, we combined (1) a novel experimental paradigm in which we produced a similar perceptual disappearance and also re-appearance by using visual adaptation with transient contrast changes, with (2) electrophysiological observations from human intracranial electrodes sampling wide brain areas. We focused on broadband high-frequency (50–150 Hz, i.e., gamma) and low-frequency (8–24 Hz) neural activity amplitude modulations related to target visibility and invisibility. We report that low-frequency amplitude modulations reflected stimulus visibility in a larger ensemble of recording sites as compared to broadband gamma responses, across distinct brain regions including occipital, temporal and frontal cortices. Moreover, the dynamics of the broadband gamma response distinguished stimulus visibility from stimulus invisibility earlier in anterior insula and inferior frontal gyrus than in temporal regions, suggesting a possible role of fronto-insular cortices in top–down processing for conscious perception. Finally, we report that in primary visual cortex only low-frequency amplitude modulations correlated directly with perceptual status. Interestingly, in this sensory area broadband gamma was not modulated during PS but became positively modulated after 300 ms when stimuli were rendered visible again, suggesting that local networks could be ignited by top–down influences during conscious perception. PMID:25642199

Estimation of chromatic errors from broadband images for high contrast imaging: sensitivity analysis

NASA Astrophysics Data System (ADS)

Sirbu, Dan; Belikov, Ruslan

2016-01-01

Many concepts have been proposed to enable direct imaging of planets around nearby stars, and which would enable spectroscopic observations of their atmospheric observations and the potential discovery of biomarkers. The main technical challenge associated with direct imaging of exoplanets is to effectively control both the diffraction and scattered light from the star so that the dim planetary companion can be seen. Usage of an internal coronagraph with an adaptive optical system for wavefront correction is one of the most mature methods and is being developed as an instrument addition to the WFIRST-AFTA space mission. In addition, such instruments as GPI and SPHERE are already being used on the ground and are yielding spectra of giant planets. For the deformable mirror (DM) to recover a dark hole region with sufficiently high contrast in the image plane, mid-spatial frequency wavefront errors must be estimated. To date, most broadband lab demonstrations use narrowband filters to obtain an estimate of the the chromaticity of the wavefront error and this can result in usage of a large percentage of the total integration time. Previously, we have proposed a method to estimate the chromaticity of wavefront errors using only broadband images; we have demonstrated that under idealized conditions wavefront errors can be estimated from images composed of discrete wavelengths. This is achieved by using DM probes with sufficient spatially-localized chromatic diversity. Here we report on the results of a study of the performance of this method with respect to realistic broadband images including noise. Additionally, we study optimal probe patterns that enable reduction of the number of probes used and compare the integration time with narrowband and IFS estimation methods.

A Broadband IR Compact High Resolution Spectrometer (BIRCHES) for a Lunar Water Distribution (LWaDi) Cubesat Mission

NASA Astrophysics Data System (ADS)

Clark, Pamela E.; Macdowall, Robert J.; Reuter, Dennis; Mauk, Robin

2014-11-01

We are in the process of developing the BIRCH (Broadband IR for Cubesats with High Resolution) Spectrometer for characterization of a range of deep space targets. BIRCH is the first extremely compact Broadband IR spectrometer with high spectral resolution designed to measure water type and component distribution for a science-driven cubesat mission, such as the lunar orbital mission LWaDi (Lunar Water Distribution) designed to determine the systematics of lunar water and volatiles as a function of time of day, latitude, and terrain. The development of cubesat form factor instruments, such as BIRCH, capable of providing high priority science goals identified in the decadal survey is critical to achieve low cost planetary exploration promised by the cubesat paradigm by exploring volatile systems via orbiting or landed packages. On the Moon, as well as Mercury, Mars, and the asteroids, the source, distribution, and role of volatiles is a question of major importance, and has implications for formation processes, including interior structure, differentiation, and the origin of life in the early solar system. The form and distribution of water has implications for human exploration, resource exploitation, and sample curation. Recent lunar missions gave unanticipated evidence for the water from NIR instruments not optimized for finding it. Our instrument includes a compact broadband HgCdTe detector with a linear variable filter and a compact cryocooler (for operation below 140K) attached to a compact optical system with 2 off-axis parabolic mirrors and variable field stop operating below 240K. Its 10 nm or better resolution and longer wavelength upper range (1.3 to 3.7 microns) are necessary to identify and separate features associated with water type (adsorbed, bound, ice) and components. Its 4-sided adjustable iris at the field stop enables a constant spot size (10 x 10 km) regardless of altitude. BIRCH will be able to provide systematic and extensive enough information to understand water’s life cycle, temporal and spatial distribution and interactions as a function of lunar cycles, characteristic features, and regolith composition.

Hyperbolic-cosine waveguide tapers and oversize rectangular waveguide for reduced broadband insertion loss in W-band electron paramagnetic resonance spectroscopy. II. Broadband characterization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sidabras, Jason W.; Anderson, James R.; Mainali, Laxman

Experimental results have been reported on an oversize rectangular waveguide assembly operating nominally at 94 GHz. It was formed using commercially available WR28 waveguide as well as a pair of specially designed tapers with a hyperbolic-cosine shape from WR28 to WR10 waveguide [R. R. Mett et al., Rev. Sci. Instrum. 82, 074704 (2011)]. The oversize section reduces broadband insertion loss for an Electron Paramagnetic Resonance (EPR) probe placed in a 3.36 T magnet. Hyperbolic-cosine tapers minimize reflection of the main mode and the excitation of unwanted propagating waveguide modes. Oversize waveguide is distinguished from corrugated waveguide, overmoded waveguide, or quasi-opticmore » techniques by minimal coupling to higher-order modes. Only the TE{sub 10} mode of the parent WR10 waveguide is propagated. In the present work, a new oversize assembly with a gradual 90° twist was implemented. Microwave power measurements show that the twisted oversize waveguide assembly reduces the power loss in the observe and pump arms of a W-band bridge by an average of 2.35 dB and 2.41 dB, respectively, over a measured 1.25 GHz bandwidth relative to a straight length of WR10 waveguide. Network analyzer measurements confirm a decrease in insertion loss of 2.37 dB over a 4 GHz bandwidth and show minimal amplitude distortion of approximately 0.15 dB. Continuous wave EPR experiments confirm these results. The measured phase variations of the twisted oversize waveguide assembly, relative to an ideal distortionless transmission line, are reduced by a factor of two compared to a straight length of WR10 waveguide. Oversize waveguide with proper transitions is demonstrated as an effective way to increase incident power and the return signal for broadband EPR experiments. Detailed performance characteristics, including continuous wave experiment using 1 μM 2,2,6,6-tetramethylpiperidine-1-oxyl in aqueous solution, provided here serve as a benchmark for other broadband low-loss probes in millimeter-wave EPR bridges.« less

Prediction of broadband ground-motion time histories: Hybrid low/high-frequency method with correlated random source parameters

USGS Publications Warehouse

Liu, P.; Archuleta, R.J.; Hartzell, S.H.

2006-01-01

We present a new method for calculating broadband time histories of ground motion based on a hybrid low-frequency/high-frequency approach with correlated source parameters. Using a finite-difference method we calculate low- frequency synthetics (< ∼1 Hz) in a 3D velocity structure. We also compute broadband synthetics in a 1D velocity model using a frequency-wavenumber method. The low frequencies from the 3D calculation are combined with the high frequencies from the 1D calculation by using matched filtering at a crossover frequency of 1 Hz. The source description, common to both the 1D and 3D synthetics, is based on correlated random distributions for the slip amplitude, rupture velocity, and rise time on the fault. This source description allows for the specification of source parameters independent of any a priori inversion results. In our broadband modeling we include correlation between slip amplitude, rupture velocity, and rise time, as suggested by dynamic fault modeling. The method of using correlated random source parameters is flexible and can be easily modified to adjust to our changing understanding of earthquake ruptures. A realistic attenuation model is common to both the 3D and 1D calculations that form the low- and high-frequency components of the broadband synthetics. The value of Q is a function of the local shear-wave velocity. To produce more accurate high-frequency amplitudes and durations, the 1D synthetics are corrected with a randomized, frequency-dependent radiation pattern. The 1D synthetics are further corrected for local site and nonlinear soil effects by using a 1D nonlinear propagation code and generic velocity structure appropriate for the site’s National Earthquake Hazards Reduction Program (NEHRP) site classification. The entire procedure is validated by comparison with the 1994 Northridge, California, strong ground motion data set. The bias and error found here for response spectral acceleration are similar to the best results that have been published by others for the Northridge rupture.

Multi-Parameter GEOSCOPE Land Stations and Ocean Bottom Observatories

NASA Astrophysics Data System (ADS)

Stutzmann, E.; Roult, G.; Montagner, J.; Karczewski, J.; Geoscope Group,.

2002-12-01

Since the mid-eighties, the number of high quality broadband stations installed over the world has increased in a spectacular way and these stations cover now most of the emerged lands, with a higher concentration in the northern hemisphere between the latitudes 0 and 60N. The GEOSCOPE program has been the first global network of 3-component broadband seismic stations and has contributed to the elaboration of the FDSN. The 25 broadband GEOSCOPE stations fulfill the FDSN criteria, the data are stored in data-centers at the IPGP and IRIS DMC and are accessible through the netdc procedure (email to netdc@ipgp.jussieu.fr) or via the web. GEOSCOPE data have contributed to the major progresses of our knowledge of the earth interior. The earthquake CMT are now determined in a routine manner and the temporal history of the seismic source is accessible for the largest earthquakes. The geographical distribution of GEOSCOPE stations, specially in the southern hemisphere, has also played an important role in improving the resolution of global tomographic models. Recent P-wave models give high resolution images of subducted slabs whereas recent S-wave models have enable to discover the two super-swells. The evolution of the GEOSCOPE program is now focused on the installation of multi-parameter stations including 3-component broadband seismic sensors, pressure gauge, thermometer and GPS receivers. These stations will enable to decrease the seismic noise, and -among others- to better characterize the background free oscillations of the earth. The seismic station earth coverage is limited by the presence of oceans and the next step is the installation of ocean bottom broadband stations. For this purpose, in 1992, a first temporary station sismobs/OFM has been working for 2 weeks, along the mid atlantic ridge. In 1997, an international multi-parameter station, MOISE has been operating during 3 months in the Monterey Bay. The further step is the installation of the station NERO in a ODP hole along the Ninety East Ridge in collaboration with IFREMER and JAMSTEC. The location of this station has been decided by the ION program and the station will be operating for at least 2 years.

Ultra-broadband infrared pump-probe spectroscopy using synchrotron radiation and a tuneable pump.

PubMed

Carroll, Lee; Friedli, Peter; Lerch, Philippe; Schneider, Jörg; Treyer, Daniel; Hunziker, Stephan; Stutz, Stefan; Sigg, Hans

2011-06-01

Synchrotron infrared sources have become popular mainly because of their excellent broadband brilliance, which enables spectroscopically resolved spatial-mapping of stationary objects at the diffraction limit. In this article we focus on an often-neglected further advantage of such sources - their unique time-structure - to bring such broadband spectroscopy to the time domain, for studying dynamic phenomenon down to the 100 ps limit. We describe the ultra-broadband (12.5 to 1.1 μm) Fourier transform pump-probe setup, for condensed matter transmission- and reflection-spectroscopy, installed at the X01DC infrared beam-line of the Swiss Light Source (SLS). The optical pump consists of a widely tuneable 100 ps 1 kHz laser system, covering 94% of the 16 to 1.1 μm range. A thorough description of the system is given, including (i) the vector-modulator providing purely electronic tuning of the pump-probe overlap up to 1 ms with sub-ps time resolution, (ii) the 500 MHz data acquisition system interfaced with the experimental physics and industrial control system (EPICS) based SLS control system for consecutive pulse sampling, and (iii) the step-scan time-slice Fourier transform scheme for simultaneous recording of the dual-channel pumped, un-pumped, and difference spectra. The typical signal/noise ratio of a single interferogram in a 100 ps time slice is 300 (measured during one single 140 s TopUp period). This signal/noise ratio is comparable to that of existing gated Globar pump-probe Fourier transform spectroscopy, but brings up to four orders of magnitude better time resolution. To showcase the utility of broadband pump-probe spectroscopy, we investigate a Ge-on-Si material system similar to that in which optically pumped direct-gap lasing was recently reported. We show that the mid-infrared reflection-spectra can be used to determine the optically injected carrier density, while the mid- and near-infrared transmission-spectra can be used to separate the strong pump-induced absorption and inversion processes present at the direct-gap energy. © 2011 American Institute of Physics

The ADN project : an integrated seismic monitoring of the northern Ecuadorian subduction

NASA Astrophysics Data System (ADS)

Nocquet, Jean-Mathieu; Yepes, Hugo; Vallee, Martin; Mothes, Patricia; Regnier, Marc; Segovia, Monica; Font, Yvonne; Vaca, Sandro; Bethoux, Nicole; Ramos, Cristina

2010-05-01

The subduction of the Nazca plate beneath South America has caused one of the largest megathrust earthquake sequence during the XXth century with three M>7.7 earthquakes that followed the great 1906 (Mw = 8.8) event. Better understanding the processes leading to the occurrence of large subduction earthquakes requires to monitor the ground motion over a large range of frequencies. We present a new network (ADN) developed under a collaboration between the IRD-GeoAzur (Nice, France) and the IG-EPN (Quito, Ecuador). Each station of the ADN network includes a GPS recording at 5 Hz, an accelerometer and a broadband seismometer. CGPS data will quantify the secular deformation induced by elastic locking along the subduction interface, enabling a detailed modelling of the coupling distribution. CGPS will be used to monitor any transient deformation induced by Episodic Slip Event along the subduction, together with broadband seismometers that can detect any tremors or seismic signatures that may accompany them. In case of any significant earthquake, 5 Hz GPS and accelerometer will provide near field data for earthquake source detailed study. Finally, the broadband seismometers will be used for study of the microseismicity and structure of the subduction zone. The network includes 9 stations, operating since 2008 and covering the coastal area from latitude 1.5°S to the Colombian border. In this poster, we will present preliminary assessment of the data, first hypocenters location, magnitude and focal mechanism determination, as well as results about an episodic slip event detected in winter 2008.

Deep Seismic Structure of the Texas-Gulf of Mexico Passive Margin

NASA Astrophysics Data System (ADS)

Pulliam, J.; Gurrola, H.

2013-12-01

The Texas-Gulf of Mexico region has witnessed a wide range of tectonic processes, including deformation due to orogeny, continental collision and rifting. Artifacts of these processes are likely to remain at lithospheric depths beneath the region but, until recently, the tools needed to examine structures at mantle depths were not available. With the passage of the EarthScope's USArray stations and the completion of a targeted broadband deployment, new images of the region's lithosphere have emerged. These images reveal lithospheric-scale anomalies that correlate strongly with surface features, such as a large fast anomaly that corresponds to the southern extent of the Laurentia (or 'Great Plains') craton and a large slow anomaly associated with the Southern Oklahoma Aulacogen. Other features that would not have been expected based on surface tectonics include a slow layer that we interpret to be a shear zone at the base of the cratonic root and the transitional continental lithosphere, and a zone that is bounded at its top and bottom by discontinuities and high levels of seismic anisotropy. Additionally a high velocity body underlying the Gulf Coast Plains may mark delaminating lower crust. If true it provides indirect evidence that active rifting best describes the process that led to the opening of the Gulf of Mexico. These new results are based upon the analysis of 326 USArray broadband seismic stations and a 23-station broadband deployment across Texas' passive margin, from Matagorda Island, a barrier island in the Gulf of Mexico, to Johnson City, TX, on the relatively undisturbed Proterozoic crust of central Texas.