Sample records for complex 39a construction
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2012-02-17
Launch Complex 39 Construction: Launch Complex 39 LC-39 was originally designed and built to launch American astronauts toward the moon. The complex stretches inland from the Atlantic Ocean across four miles of what, until 1963, was a land of intermittent marshes and sandy scrub growth. In less than four years, starting with 1963 and ending with 1966, it was transformed into an operational spaceport embodying a mobile concept: rockets and spacecraft are erected in one area and transported to a separate location for launch. A total of 153 vehicles have been launched from LC-39. Poster designed by Kennedy Space Center Graphics Department/Greg Lee. Credit: NASA
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Flame Deflector Complete at Launch Complex 39B
2018-05-16
Construction is complete on the main flame deflector in the flame trench at Launch Complex 39B at NASA's Kennedy Space Center in Florida. The flame deflector will safely deflect the plume exhaust from NASA's Space Launch System rocket during launch. It will divert the rocket's exhaust, pressure and intense heat to the north at liftoff. The Exploration Ground Systems Program at Kennedy is refurbishing the pad to support the launch of the SLS rocket and Orion on Exploration Mission-1, and helping to transform the space center into a multi-user spaceport.
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54. VAL COUNTERWEIGHT CAR DURING CONSTRUCTION SHOWING CAR FRAME, WHEEL ...
54. VAL COUNTERWEIGHT CAR DURING CONSTRUCTION SHOWING CAR FRAME, WHEEL ASSEMBLIES AND METAL REINFORCING, December 19, 1947. (Original photograph in possession of Dave Willis, San Diego, California.) - Variable Angle Launcher Complex, Variable Angle Launcher, CA State Highway 39 at Morris Reservior, Azusa, Los Angeles County, CA
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NASA Technical Reports Server (NTRS)
2004-01-01
KENNEDY SPACE CENTER, FLA. Towers and girders are the current construction components on the Operations Support Building (OSB) II in the Launch Complex 39 Area. The new building, which replaces modular housing constructed more than 20 years ago, will house NASA and contractor support staff for shuttle operations. The new structure is projected to be ready in April 2005.
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NASA Technical Reports Server (NTRS)
2004-01-01
KENNEDY SPACE CENTER, FLA. Another phase of construction is shown on the Operations Support Building (OSB) II in the Launch Complex 39 Area. The new building, which replaces modular housing constructed more than 20 years ago, will house NASA and contractor support staff for shuttle operations. The new structure is projected to be ready in April 2005.
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NASA Technical Reports Server (NTRS)
2004-01-01
KENNEDY SPACE CENTER, FLA. Towers and girders are the current construction components on the Operations Support Building (OSB) II in the Launch Complex 39 Area. The new building, which replaces modular housing constructed more than 20 years ago, will house NASA and contractor support staff for shuttle operations. The new structure is projected to be ready in April 2005.
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NASA Technical Reports Server (NTRS)
2004-01-01
KENNEDY SPACE CENTER, FLA. Towers and girders are the current construction components on the Operations Support Building (OSB) II in the Launch Complex 39 Area. The new building, which replaces modular housing constructed more than 20 years ago, will house NASA and contractor support staff for shuttle operations. The new structure is projected to be ready in April 2005.
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Large Crawler Crane for new lightning protection system
2007-10-25
A large crawler crane arrives at the turn basin at the Launch Complex 39 Area on NASA's Kennedy Space Center. The crane with its 70-foot boom will be moved to Launch Pad 39B and used to construct a new lightning protection system for the Constellation Program and Ares/Orion launches. Pad B will be the site of the first Ares vehicle launch, including Ares I-X which is scheduled for April 2009.
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2012-04-17
CAPE CANAVERAL, Fla. – This aerial view over NASA’s Kennedy Space Center in Florida reveals a new road winding its way from Space Commerce Way, in the foreground, past the construction site for the new Exploration Park, to the Space Life Sciences Laboratory SLSL. At right is Kennedy’s Industrial Area. Spanning the background is the Atlantic Ocean. In the distance, the facilities in Launch Complex 39 are, from left, the Vehicle Assembly Building, Pad 39B, Pad 39A, and Space Launch Complex-41 on Cape Canaveral Air Force Station. The land was cleared for the first phase of construction following the park’s groundbreaking in June 2010. The park encompasses 60 acres just outside Kennedy’s security gates near the Kennedy Space Center Visitor Complex. Exploration Park is designed to be a strategically located complex, adjacent to the SLSL, for servicing diverse tenants and uses that will engage in activities to support the space-related activities of NASA, other government agencies and the U.S. commercial space industry, as well as attract new aerospace work to the Space Coast. Its nine sustainable, state-of-the-art buildings will include educational, office, research and laboratory, and high-bay facilities and provide 350,000-square feet of work space. Each building is expected to qualify for the U.S. Green Building Council’s Leadership in Environmental and Energy Design LEED certification. The SLSL will be the anchor facility for the park. Photo credit: NASA/Glenn Benson
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Large Crawler Crane for new lightning protection system
2007-10-25
A large crawler crane begins moving away from the turn basin at the Launch Complex 39 Area on NASA's Kennedy Space Center. The crane with its 70-foot boom will be moved to Launch Pad 39B and used to construct a new lightning protection system for the Constellation Program and Ares/Orion launches. Pad B will be the site of the first Ares vehicle launch, including Ares I-X which is scheduled for April 2009.
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2017-06-30
At NASA's Kennedy Space Center in Florida, cement is poured as part of a construction project to upgrade the turn basin wharf. The work includes driving multiple precast concrete piles to a depth of about 70 feet to accommodate arrival of the core stage for the agency's Space Launch System (SLS) rocket. When the stage for NASA's SLS departs the Michoud Assembly Facility in New Orleans, it will be shipped by the agency's modified barge to the Launch Complex 39 turn basin.
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2017-06-30
Across from the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida, cement trucks stand by to support a construction project to upgrade the turn basin wharf. The work includes driving multiple precast concrete piles to a depth of about 70 feet to accommodate arrival of the core stage for the agency's Space Launch System (SLS) rocket. When the stage for NASA's SLS departs the Michoud Assembly Facility in New Orleans, it will be shipped by the agency's modified barge to the Launch Complex 39 turn basin.
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2017-06-30
Across from the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida, cement is poured as part of a construction project to upgrade the turn basin wharf. The work includes driving multiple precast concrete piles to a depth of about 70 feet to accommodate arrival of the core stage for the agency's Space Launch System (SLS) rocket. When the stage for NASA's SLS departs the Michoud Assembly Facility in New Orleans, it will be shipped by the agency's modified barge to the Launch Complex 39 turn basin.
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2013-06-14
CAPE CANAVERAL, Fla. – At the Kennedy Space Center in Florida, a fitness trail is under construction in the Launch Complex 39 area just west of the Press Site. Designed in the shape of a space shuttle, the trail will provide an opportunity for employees at the spaceport to stay physically fit. Photo credit: NASA/Jim Grossmann
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2012-02-17
Industrial Area Construction: Located 5 miles south of Launch Complex 39, construction of the main buildings -- Operations and Checkout Building, Headquarters Building, and Central Instrumentation Facility – began in 1963. In 1992, the Space Station Processing Facility was designed and constructed for the pre-launch processing of International Space Station hardware that was flown on the space shuttle. Along with other facilities, the industrial area provides spacecraft assembly and checkout, crew training, computer and instrumentation equipment, hardware preflight testing and preparations, as well as administrative offices. Poster designed by Kennedy Space Center Graphics Department/Greg Lee. Credit: NASA
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Final Flame Trench Brick Installation at Launch Pad 39B
2017-05-09
A construction worker installs one of the final bricks on the north side of the flame trench at Launch Complex 39B at NASA's Kennedy Space Center in Florida. The walls of the flame trench are being upgraded to withstand the intense heat and fire at launch of NASA's Space Launch System rocket with Orion atop. About 96,000 heat-resistant bricks, in three different sizes, were secured to the walls using bonding mortar in combination with adhesive anchors. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to Pad 39B to support the launch of the SLS and Orion spacecraft for Exploration Mission-1 and NASA’s journey to Mars.
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Final Flame Trench Brick Installation at Launch Pad 39B
2017-05-09
A construction worker installs the final brick on the north side of the flame trench at Launch Complex 39B at NASA's Kennedy Space Center in Florida. The walls of the flame trench are being upgraded to withstand the intense heat and fire at launch of NASA's Space Launch System rocket with Orion atop. About 96,000 heat-resistant bricks, in three different sizes, were secured to the walls using bonding mortar in combination with adhesive anchors. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to Pad 39B to support the launch of the SLS and Orion spacecraft for Exploration Mission-1 and NASA’s journey to Mars.
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Ground Combat Training Squadron Complex Final Environmental Assessment
2011-08-01
Std Z39-18 FINAL FINDING OF NO SIGNIFICANT IMPACT FROM CONSTRUCTION OF THE GROUND COMBAT TRAINING SQUADRON COMPLEX AT EGLIN AIR FORCE BASE...of and Adjacent to the Triangle (EA Section 2.4.1, Page 2-10): This location was eliminated due to possibly unavoidable impacts to wetlands, which run...through part of this site. To eliminate any potential for impacts to wetlands, this alternative was dismissed. Training in an Area Northwest of
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Final Flame Trench Brick Installation at Launch Pad 39B
2017-05-09
Construction workers sign the final bricks after they were installed on the north side of the flame trench at Launch Complex 39B at NASA’s Kennedy Space Center in Florida. The walls of the flame trench are being upgraded to withstand the intense heat and fire at launch of NASA's Space Launch System rocket with Orion atop. About 96,000 heat-resistant bricks, in three different sizes, were secured to the walls using bonding mortar in combination with adhesive anchors. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to Pad 39B to support the launch of the SLS and Orion spacecraft for Exploration Mission-1 and NASA’s journey to Mars.
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Final Flame Trench Brick Installation at Launch Pad 39B
2017-05-09
Construction workers install the final bricks on the north side of the flame trench at Launch Complex 39B at NASA's Kennedy Space Center in Florida. The walls of the flame trench are being upgraded to withstand the intense heat and fire at launch of NASA's Space Launch System rocket with Orion atop. About 96,000 heat-resistant bricks, in three different sizes, were secured to the walls using bonding mortar in combination with adhesive anchors. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to Pad 39B to support the launch of the SLS and Orion spacecraft for Exploration Mission-1 and NASA’s journey to Mars.
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2017-06-14
Modifications are underway at the Launch Complex 39 turn basin wharf at NASA's Kennedy Space Center in Florida to prepare for the arrival of the agency's massive Space Launch System (SLS) core booster aboard the barge Pegasus. Construction workers with Southeast Cherokee Construction Inc. work to shore up the turn basin area. A crane will be used to lift up precast concrete poles and position them to be driven to a depth of about 70 feet into the bedrock below the water around the turn basin. The upgrades are necessary to accommodate the 300,000-pound core booster aboard the modified Pegasus barge. The Ground Systems Development and Operations Program is overseeing the upgrades to the turn basin wharf.
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Environmental Control Subsystem Development
NASA Technical Reports Server (NTRS)
Laidlaw, Jacob; Zelik, Jonathan
2017-01-01
Kennedy Space Center's Launch Pad 39B, part of Launch Complex 39, is currently undergoing construction to prepare it for NASA's Space Launch System missions. The Environmental Control Subsystem, which provides the vehicle with an air or nitrogen gas environment, required development of its local and remote display screens. The remote displays, developed by NASA contractors and previous interns, were developed without complete functionality; the remote displays were revised, adding functionality to over 90 displays. For the local displays, multiple test procedures were developed to assess the functionality of the screens, as well as verify requirements. One local display screen was also developed.
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2013-06-14
CAPE CANAVERAL, Fla. – At the Kennedy Space Center in Florida, a fitness trail is under construction in the Launch Complex 39 area across from the Vehicle Assembly Building and just west of the Press Site. This panoramic image shows that that trail is being designed in the shape of a space shuttle. The trail will provide an opportunity for employees at the spaceport to stay physically fit. Photo credit: NASA/Jim Grossmann
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2017-06-14
Modifications are underway at the Launch Complex 39 turn basin wharf at NASA's Kennedy Space Center in Florida to prepare for the arrival of the agency's massive Space Launch System (SLS) core stage aboard the barge Pegasus. Tammy Kelly, in the center, site manager, with Southeast Cherokee Construction Inc. talks with construction workers. A crane will be used to lift up precast concrete poles and position them to be driven to a depth of about 70 feet into the bedrock below the water around the turn basin. The upgrades are necessary to accommodate the increased weight of the core stage along with ground support and transportation equipment aboard the modified barge Pegasus. The Ground Systems Development and Operations Program is overseeing the upgrades to the turn basin wharf.
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2004-03-26
CAPE CANAVERAL, Fla. -- The 525-foot high Vehicle Assembly Building dominates the Launch Complex 39 Area. On the right is the Launch Control Center. To the left are the Orbiter Processing Facility Bays 1, 2 and 3. At lower left is the Operation Support Building at lower right is the construction area for Operations Support Building 2. Behind the VAB meanders the Banana Creek. Photo credit: NASA
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2010-11-24
CAPE CANAVERAL, Fla. -- Construction begins to wrap up at the Propellants North Administrative and Maintenance Facility in the Launch Complex 39 area of NASA's Kennedy Space Center in Florida. This is the facility's two-story administrative building, which will house managers, mechanics and technicians who fuel spacecraft at Kennedy. Next door is a single-story shop that will be used to store cryogenic fuel transfer equipment. The facility is striving to qualify for the U.S. Green Building Council’s Leadership in Energy and Environmental Design (LEED) Platinum certification, which is the highest of LEED ratings. The facility, set to be complete in December 2010, was designed for NASA by Jones Edmunds and Associates. H. W. Davis Construction is the construction contractor. Photo credit: NASA/Frankie Martin
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2010-11-24
CAPE CANAVERAL, Fla. -- Construction begins to wrap up at the Propellants North Administrative and Maintenance Facility in the Launch Complex 39 area of NASA's Kennedy Space Center in Florida. This is the facility's two-story administrative building, which will house managers, mechanics and technicians who fuel spacecraft at Kennedy. Next door is a single-story shop that will be used to store cryogenic fuel transfer equipment. The facility is striving to qualify for the U.S. Green Building Council’s Leadership in Energy and Environmental Design (LEED) Platinum certification, which is the highest of LEED ratings. The facility, set to be complete in December 2010, was designed for NASA by Jones Edmunds and Associates. H. W. Davis Construction is the construction contractor. Photo credit: NASA/Frankie Martin
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2010-11-24
CAPE CANAVERAL, Fla. -- Construction begins to wrap up at the Propellants North Administrative and Maintenance Facility in the Launch Complex 39 area of NASA's Kennedy Space Center in Florida. On the left is the facility's single-story shop, which will be used to store cryogenic fuel transfer equipment. On the right is a two-story administrative building that will house managers, mechanics and technicians who fuel spacecraft at Kennedy. The facility is striving to qualify for the U.S. Green Building Council’s Leadership in Energy and Environmental Design (LEED) Platinum certification, which is the highest of LEED ratings. The facility, set to be complete in December 2010, was designed for NASA by Jones Edmunds and Associates. H. W. Davis Construction is the construction contractor. Photo credit: NASA/Frankie Martin
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2009-05-18
serves as a didactic tool to understand the information required for the approach to coordinate free tracking and navigation problems. Observe that the...layout (left), and in the CN -Complex (right). These paths can be compared by using the algebraic topological tools covered in chapter 2. . . . 34 3.9...right). mathematical tools necessary to make our discussion formal; chapter 3 will present the construction of a simplicial representation called
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39. TUNNEL BORE UNDER CONSTRUCTION. VIEW SHOWS LIGHT CONSTRUCTION RAILWAY ...
39. TUNNEL BORE UNDER CONSTRUCTION. VIEW SHOWS LIGHT CONSTRUCTION RAILWAY FOR HAULING MUCK AND SPOIL - Zion-Mount Carmel Highway, Tunnel, Two miles east of Zion Canyon Scenic Drive, Springdale, Washington County, UT
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The Shock and Vibration Digest. Volume 16, Number 6
1984-06-01
formulation is emphasized. Tabarrok [5] used both fluid variables to construct dual variational principles; these can be used as the basis for...Metal Working and Forming 37 STRUCTURAL SYSTEMS 39 Buildings 39 Towers 39 Foundations 40 Harbors and Dams 40 Roads and Tracks 41 Construction ...under the fating. Assuming that the super-structure is composed of idertically constructed story-units and the soil behavior is characterized by a
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2009-02-12
CAPE CANAVERAL, Fla. – An aerial view of a mobile launcher platform that is parked in the Launch Complex 39 Area at NASA's Kennedy Space Center in Florida. The platform, which is a moveable base for the launch of space shuttle, is a two-story steel structure 25 feet high, 160 feet long and 135 feet wide. It is constructed of welded steel up to 6 inches thick. The platform rests on six 22-foot-tall pedestals. Photo credit: NASA/Kim Shiflett
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2009-02-12
CAPE CANAVERAL, Fla. – An aerial view of a mobile launcher platform that is parked in the Launch Complex 39 Area at NASA's Kennedy Space Center in Florida. The platform, which is a moveable base for the launch of space shuttle, is a two-story steel structure 25 feet high, 160 feet long and 135 feet wide. It is constructed of welded steel up to 6 inches thick. The platform rests on six 22-foot-tall pedestals. Photo credit: NASA/Kim Shiflett
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2009-02-12
CAPE CANAVERAL, Fla. – An aerial view of a mobile launcher platform that is parked in the Launch Complex 39 Area at NASA's Kennedy Space Center in Florida. The platform, which is a moveable base for the launch of space shuttle, is a two-story steel structure 25 feet high, 160 feet long and 135 feet wide. It is constructed of welded steel up to 6 inches thick. The platform rests on six 22-foot-tall pedestals. Photo credit: NASA/Kim Shiflett
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22 CFR 228.39 - Special source rules for construction and engineering services.
Code of Federal Regulations, 2010 CFR
2010-04-01
... engineering services. 228.39 Section 228.39 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT RULES ON... engineering services. Advanced developing countries, eligible under Geographic Code 941, which have attained a competitive capability in international markets for construction services or engineering services are not...
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22 CFR 228.39 - Special source rules for construction and engineering services.
Code of Federal Regulations, 2011 CFR
2011-04-01
... engineering services. 228.39 Section 228.39 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT RULES ON... engineering services. Advanced developing countries, eligible under Geographic Code 941, which have attained a competitive capability in international markets for construction services or engineering services are not...
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Adult Congenital Heart Disease Patients Experience Similar Symptoms of Disease Activity.
Cedars, Ari M; Stefanescu Schmidt, Ada; Broberg, Craig; Zaidi, Ali; Opotowsky, Alexander; Grewal, Jasmine; Kay, Joseph; Bhatt, Ami B; Novak, Eric; Spertus, John
2016-03-01
There is a lack of objective data on the symptoms characterizing disease activity among adults with congenital heart disease (ACHD). The purpose of this study was to elicit the most important symptoms from patients across the spectrum of ACHD and to examine whether reported symptoms were similar across the spectrum of ACHD as a foundation for creating a patient-reported outcome measure(s). We constructed a 39-item survey using input from physicians specializing in ACHD to assess the symptoms patients associate with disease activity. Patients (n=124) prospectively completed this survey, and the results were analyzed based on underlying anatomy and disease complexity. A confirmatory cohort of patients (n=40) was then recruited prospectively to confirm the validity of the initial data. When grouped based on underlying anatomy, significant differences in disease-related symptom rankings were found for only 6 of 39 symptoms. Six symptoms were identified which were of particular significance to patients, regardless of underlying anatomy. Patients with anatomy of great complexity experienced greater overall symptom severity than those with anatomy of low or moderate complexity, attributable exclusively to higher ranking of 5 symptoms. The second patient cohort had symptom experiences similar to those of the initial cohort, differing in only 5 of 39 symptoms. This study identified 6 symptoms relevant to patients across the spectrum of ACHD and remarkable homogeneity of patient experience, suggesting that a single disease-specific patient-reported outcome can be created for quality and outcome assessments. © 2016 American Heart Association, Inc.
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14 CFR 33.39 - Lubrication system.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Lubrication system. 33.39 Section 33.39... system. (a) The lubrication system of the engine must be designed and constructed so that it will... supply is in the engine. (b) The lubrication system of the engine must be designed and constructed to...
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DART Support for Hurricane Matthew
2016-10-18
A construction trailer damaged by Hurricane Matthew is seen in the Launch Complex 39 area at NASA's Kennedy Space Center in Florida. Assessments and repairs are in progress at various structures and facilities across the spaceport, part of the ongoing recovery from Hurricane Matthew, which passed to the east of Kennedy on Oct. 6 and 7, 2016. The center received some isolated roof damage, damaged support buildings, a few downed power lines, and limited water intrusion. Beach erosion also occurred, although the storm surge was less than expected.
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39 CFR 776.6 - Design requirements for construction.
Code of Federal Regulations, 2011 CFR
2011-07-01
... 39 Postal Service 1 2011-07-01 2011-07-01 false Design requirements for construction. 776.6 Section 776.6 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Floodplain Management § 776.6 Design requirements for construction. If structures impact, are located in, or support development in a...
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2017-06-14
Modifications are underway at the Launch Complex 39 turn basin wharf at NASA's Kennedy Space Center in Florida to prepare for the arrival of the agency's massive Space Launch System (SLS) core stage aboard the barge Pegasus. In the foreground is Tammy Kelly, site manager, with Southeast Cherokee Construction Inc. A crane will be used to lift up precast concrete poles and position them to be driven to a depth of about 70 feet into the bedrock below the water around the turn basin. The upgrades are necessary to accommodate the increased weight of the core stage along with ground support and transportation equipment aboard the modified barge Pegasus. The Ground Systems Development and Operations Program is overseeing the upgrades to the turn basin wharf.
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Construction bidding cost of KSC's space shuttle facilities
NASA Technical Reports Server (NTRS)
Brown, Joseph Andrew
1977-01-01
The bidding cost of the major Space Transportation System facilities constructed under the responsibility of the John F. Kennedy Space Center (KSC) is described and listed. These facilities and Ground Support Equipment (GSE) are necessary for the receiving, assembly, testing, and checkout of the Space Shuttle for launch and landing missions at KSC. The Shuttle launch configuration consists of the Orbiter, the External Tank, and the Solid Rocket Boosters (SRB). The reusable Orbiter and SRB's is the major factor in the program that will result in lowering space travel costs. The new facilities are the Landing Facility; Orbiter Processing Facility; Orbiter Approach and Landing Test Facility (Dryden Test Center, California); Orbiter Mating Devices; Sound Suppression Water System; and Emergency Power System for LC-39. Also, a major factor was to use as much Apollo facilities and hardware as possible to reduce the facilities cost. The alterations to existing Apollo facilities are the VAB modifications; Mobile Launcher Platforms; Launch Complex 39 Pads A and B (which includes a new concept - the Rotary Service Structure), which was featured in ENR, 3 Feb. 1977, 'Hinged Space Truss will Support Shuttle Cargo Room'; Launch Control Center mods; External Tank and SRB Processing and Storage; Fluid Test Complex mods; O&C Spacelab mods; Shuttle mods for Parachute Facility; SRB Recovery and Disassembly Facility at Hangar 'AF'; and an interesting GSE item - the SRB Dewatering Nozzle Plug Sets (Remote Controlled Submarine System) used to inspect and acquire for reuse of SRB's.
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39 CFR 776.6 - Design requirements for construction.
Code of Federal Regulations, 2010 CFR
2010-07-01
... 39 Postal Service 1 2010-07-01 2010-07-01 false Design requirements for construction. 776.6 Section 776.6 Postal Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Floodplain Management § 776.6 Design requirements for construction. If structures impact, are...
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2011-12-11
CAPE CANAVERAL, Fla. – Workers supervise the transporter carrying the high-fidelity space shuttle model that was on display at the NASA Kennedy Space Center Visitor Complex in Florida as it rolls onto NASA Causeway at the visitor complex on its way to NASA Kennedy Space Center's Launch Complex 39 turn basin. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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DART Support for Hurricane Matthew
2016-10-18
A construction trailer damaged by Hurricane Matthew is seen in front of the Mobile Launcher within the Launch Complex 39 area at NASA's Kennedy Space Center in Florida. Assessments and repairs are in progress at various structures and facilities across the spaceport, part of the ongoing recovery from Hurricane Matthew, which passed to the east of Kennedy on Oct. 6 and 7, 2016. The center received some isolated roof damage, damaged support buildings, a few downed power lines, and limited water intrusion. Beach erosion also occurred, although the storm surge was less than expected.
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2001-06-20
CAPE CANAVERAL, Fla. – An aerial view of Launch Complex 39 shows the south and west sides of the Vehicle Assembly Building. The curved roadway heading to the VAB leads to high bay 2, the Safe Haven facility constructed in 2000. Beyond it is the Orbiter Processing Facility, bays 1 and 2. The OPF bay 3 is farther still, closer to the VAB. Farther in the background are the waters of the Banana Creek in the Merritt Island National Wildlife Refuge. Photo credit: NASA
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Identity theft and consumers' reaction to preventive technological innovations.
Ainscough, Thomas L; Brody, Richard G; Trocchia, Philip J
2007-08-01
The use of identification technology by commercial entities has broad and, for some consumers, disturbing social implications. This two-phase study was done to specify consumers' concerns regarding various identification technologies which may be encountered in retail environments. From the qualitative findings, a 26-item survey was constructed to quantify identified areas of concern with 303 survey participants (147 women and 156 men), whose mean age category was 30 to 39 years. Using exploratory factor analysis (principal components with varimax rotation), five dimensions of consumers' concern emerged: privacy, ethics, health, humanity, and complexity.
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2014-04-14
CAPE CANAVERAL, Fla. -- At Kennedy Space Center's Launch Pad 39A, from the left, NASA Administrator Charlie Bolden, Gwynne Shotwell, president and chief operating officer of Space Exploration Technologies SpaceX and Kennedy Space Center Director Bob Cabana pose in from the of the historic launch complex after announcing that NASA has just signed a lease agreement with SpaceX for use and operation of Launch Complex 39A. SpaceX will use Launch Complex 39A for rockets such as the Falcon Heavy, currently under development. Both launch pad 39A and 39B were originally built for the Apollo/Saturn V rockets that launched American astronauts on their historic journeys to the moon and later modified to support the 30-year shuttle program. Pad 39B is now being modified by NASA to support the Space Launch System SLS rocket boosting the Orion spacecraft part of the agency’s plan to explore beyond low-Earth orbit. To learn more about Launch Pad 39A visit: http://www.nasa.gov/mission_pages/shuttle/launch/launch-complex39-toc.html Photo credit: NASA/Dan Casper
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2014-04-14
CAPE CANAVERAL, Fla. -- At Kennedy Space Center's Launch Pad 39A, Gwynne Shotwell, president and chief operating officer of Space Exploration Technologies SpaceX of Hawthorne, Calif., announces that NASA has just signed a lease agreement with SpaceX for use and operation of Launch Complex 39A. SpaceX will use Launch Complex 39A for rockets such as the Falcon Heavy, currently under development. Both launch pad 39A and 39B were originally built for the Apollo/Saturn V rockets that launched American astronauts on their historic journeys to the moon and later modified to support the 30-year shuttle program. Pad 39B is now being modified by NASA to support the Space Launch System SLS rocket boosting the Orion spacecraft part of the agency’s plan to explore beyond low-Earth orbit. To learn more about Launch Pad 39A visit: http://www.nasa.gov/mission_pages/shuttle/launch/launch-complex39-toc.html Photo credit: NASA/Dan Casper
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2014-04-14
CAPE CANAVERAL, Fla. -- At Kennedy Space Center Launch Pad 39A, NASA Administrator Charlie Bolden announces that NASA has just signed a lease agreement with Space Exploration Technologies SpaceX of Hawthorne, Calif., for use and operation of Launch Complex 39A. SpaceX will use Launch Complex 39A for rockets such as the Falcon Heavy, currently under development. Both launch pad 39A and 39B were originally built for the Apollo/Saturn V rockets that launched American astronauts on their historic journeys to the moon and later modified to support the 30-year shuttle program. Pad 39B is now being modified by NASA to support the Space Launch System SLS rocket boosting the Orion spacecraft part of the agency’s plan to explore beyond low-Earth orbit. To learn more about Launch Pad 39A visit: http://www.nasa.gov/mission_pages/shuttle/launch/launch-complex39-toc.html Photo credit: NASA/Dan Casper
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2014-04-14
CAPE CANAVERAL, Fla. -- At Kennedy Space Center Launch Pad 39A, NASA Administrator Charlie Bolden announces that NASA has just signed a lease agreement with Space Exploration Technologies SpaceX of Hawthorne, Calif., for use and operation of Launch Complex 39A. SpaceX will use Launch Complex 39A for rockets such as the Falcon Heavy, currently under development. Both launch pad 39A and 39B were originally built for the Apollo/Saturn V rockets that launched American astronauts on their historic journeys to the moon and later modified to support the 30-year shuttle program. Pad 39B is now being modified by NASA to support the Space Launch System SLS rocket boosting the Orion spacecraft part of the agency’s plan to explore beyond low-Earth orbit. To learn more about Launch Pad 39A visit: http://www.nasa.gov/mission_pages/shuttle/launch/launch-complex39-toc.html Photo credit: NASA/Dan Casper
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida rolls to a stop at Kennedy's Launch Complex 39 turn basin. In the background at left is the Operations Support Building II. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida backs toward its destination, Kennedy's Launch Complex 39 turn basin. The Vehicle Assembly Building across the street towers 525 feet above it. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-12
CAPE CANAVERAL, Fla. – Wheels are installed on the high-fidelity space shuttle model following its arrival at Kennedy's Launch Complex 39 turn basin in Florida. The model was on display at the NASA Kennedy Space Center Visitor Complex until recently. In the distance is the Operations Support Building I. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Jim Grossmann
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida backs through the Press Site parking lot toward Kennedy's Launch Complex 39 turn basin. Behind it, the Vehicle Assembly Building towers 525 feet into the sky. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida rolls through the parking lot leading to Kennedy's Launch Complex 39 turn basin. Behind it are the 525-foot-tall Vehicle Assembly Building and the Launch Control Center. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-12
CAPE CANAVERAL, Fla. – Wheels are installed on the high-fidelity space shuttle model following its arrival at Kennedy's Launch Complex 39 turn basin in Florida. The model was on display at the NASA Kennedy Space Center Visitor Complex until recently. Behind it is the 525-foot-tall Vehicle Assembly Building. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Jim Grossmann
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida approaches the 525-foot-tall Vehicle Assembly Building as it makes its way to Kennedy's Launch Complex 39 turn basin. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida turns into the parking lot leading to Kennedy's Launch Complex 39 turn basin. Behind it is the 525-foot-tall Vehicle Assembly Building. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida travels down Contractor Road on its way to Kennedy's Launch Complex 39 turn basin. In the distance is the 525-foot-tall Vehicle Assembly Building. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida rolls through the Press Site parking lot toward Kennedy's Launch Complex 39 turn basin. Behind it, the Vehicle Assembly Building towers 525 feet in the air. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida seems out of place when viewed across the water of Kennedy's Launch Complex 39 turn basin. The Vehicle Assembly Building across the street towers 525 feet above it. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida makes its way through the center to Kennedy's Launch Complex 39 turn basin. In the distance is the 525-foot-tall Vehicle Assembly Building. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida passes in front of the 525-foot-tall Vehicle Assembly Building as it makes its way to Kennedy's Launch Complex 39 turn basin. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida travels down Saturn Causeway as it makes its way to Kennedy's Launch Complex 39 turn basin. In the background is the Operations Support Building I. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – Support personnel pull the transporter from beneath the high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida following its delivery to Kennedy's Launch Complex 39 turn basin. Across the street is the 525-foot-tall Vehicle Assembly Building. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – Pedestals support the high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida following its delivery to Kennedy's Launch Complex 39 turn basin. Behind it, the Vehicle Assembly Building towers 525 feet in the air. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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Hung, Kuang-Chen; Lin, Meng-Liang; Hsu, Shih-Wei; Lee, Chuan-Chun; Huang, Ren-Yu; Wu, Tian-Shung; Chen, Shih-Shun
2018-06-15
Targeting cell cycle regulators has been a suggested mechanism for therapeutic cancer strategies. We report here that the bichalcone analog TSWU-CD4 induces S phase arrest of human cancer cells by inhibiting the formation of cyclin A-phospho (p)-cyclin-dependent kinase 2 (CDK2, threonine [Thr] 39) complexes, independent of mutant p53 expression. Ectopic expression of CDK2 (T39E), which mimics phosphorylation of the Thr 39 residue of CDK2, partially rescues the cells from TSWU-CD4-induced S phase arrest, whereas phosphorylation-deficient CDK2 (T39A) expression regulates cell growth with significant S phase arrest and enhances TSWU-CD4-triggered S phase arrest. Decreased histone deacetylase 3 (HDAC3) expression after TSWU-CD4 treatment was demonstrated, and TSWU-CD4 induced S phase arrest and inhibitory effects on cyclin A expression and CDK2 Thr 39 phosphorylation, while cyclin A-p-CDK2 (Thr 39) complex formation was suppressed by ectopic wild-type HDAC3 expression. The co-transfection of CDK2 (T39E) along with HDAC3 completely restored cyclin A expression, Thr 39-phosphorylated CDK2, cyclin A-p-CDK2 (Thr 39) complex formation, and the S phase population to normal levels. Protein kinase B (Akt) inactivation was required for TSWU-CD4-induced S phase cell cycle arrest, because constitutively active Akt1 blocks the induction of S phase arrest and the suppression of cyclin A and HDAC3 expression, CDK2 Thr 39 phosphorylation, and cyclin A-p-CDK2 (Thr 39) complex formation by TSWU-CD4. Taken together, our results indicate that TSWU-CD4 induces S phase arrest by inhibiting Akt-mediated HDAC3 expression and CDK2 Thr 39 phosphorylation to suppress the formation of cyclin A-p-CDK2 (Thr 39) complexes. Copyright © 2018 Elsevier B.V. All rights reserved.
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Photocopy of drawing. LAUNCH COMPLEX 39. NASA, John F. Kennedy ...
Photocopy of drawing. LAUNCH COMPLEX 39. NASA, John F. Kennedy Space Center, Florida. File Number 203-100, Urbahn-Roberts-Seelye-Moran, October, 1963. LCC FLOOR 3, LEVEL 38-0, AREA P. Sheet 29-39 - Cape Canaveral Air Force Station, Launch Complex 39, Launch Control Center, LCC Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL
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14 CFR 151.39 - Project eligibility.
Code of Federal Regulations, 2014 CFR
2014-01-01
... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Project eligibility. 151.39 Section 151.39... FEDERAL AID TO AIRPORTS Rules and Procedures for Airport Development Projects § 151.39 Project eligibility. (a) A project for construction or land acquisition may not be approved under subparts B and C unless...
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14 CFR 151.39 - Project eligibility.
Code of Federal Regulations, 2012 CFR
2012-01-01
... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Project eligibility. 151.39 Section 151.39... FEDERAL AID TO AIRPORTS Rules and Procedures for Airport Development Projects § 151.39 Project eligibility. (a) A project for construction or land acquisition may not be approved under subparts B and C unless...
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14 CFR 151.39 - Project eligibility.
Code of Federal Regulations, 2013 CFR
2013-01-01
... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Project eligibility. 151.39 Section 151.39... FEDERAL AID TO AIRPORTS Rules and Procedures for Airport Development Projects § 151.39 Project eligibility. (a) A project for construction or land acquisition may not be approved under subparts B and C unless...
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In the Making: Constructing In-School Pregnancy in Mozambique
ERIC Educational Resources Information Center
Salvi, Francesca
2018-01-01
This article examines current in-school pregnancy policy in Mozambique, Decree 39/GM/2003, discussing how it discursively constructs in-school pregnancy as a problem, thereby raising the need to regulate its occurrence. Decree 39/GM/2003 indicates that pregnant schoolgirls should be transferred to night courses in order to complete their…
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DART Support for Hurricane Matthew
2016-10-18
A damaged construction trailer and several pieces of associated debris, aftermath of Hurricane Matthew, are seen in front of the Mobile Launcher in the Launch Complex 39 area at NASA's Kennedy Space Center in Florida. Assessments and repairs are in progress at various structures and facilities across the spaceport, part of the ongoing recovery from Hurricane Matthew, which passed to the east of Kennedy on Oct. 6 and 7, 2016. The center received some isolated roof damage, damaged support buildings, a few downed power lines, and limited water intrusion. Beach erosion also occurred, although the storm surge was less than expected.
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DART Support for Hurricane Matthew
2016-10-18
A damaged construction trailer and several pieces of associated debris, aftermath of Hurricane Matthew, are seen near the Mobile Launcher in the Launch Complex 39 area at NASA's Kennedy Space Center in Florida. Assessments and repairs are in progress at various structures and facilities across the spaceport, part of the ongoing recovery from Hurricane Matthew, which passed to the east of Kennedy on Oct. 6 and 7, 2016. The center received some isolated roof damage, damaged support buildings, a few downed power lines, and limited water intrusion. Beach erosion also occurred, although the storm surge was less than expected.
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2011-02-08
CAPE CANAVERAL, Fla. -- NASA's Kennedy Space Center in Florida hosts a ribbon-cutting ceremony at a new 18,500-square-foot Electrical Maintenance Facility (EMF) officially opening for business. Addressing the attendees is NASA Construction of Facility Project Manager Nick Rivieccio. Located in Kennedy's Launch Complex 39 area, the EMF will provide new and renovated space for maintenance shops, offices, and equipment and material storage in support of the electrical maintenance functions for the center. The facility is projected to receive Gold certification under the U.S. Green Building Council’s Leadership in Energy and Environmental Design (LEED) rating system. Photo credit: NASA/ Troy Cryder
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2017-06-14
Modifications are underway at the Launch Complex 39 turn basin wharf at NASA's Kennedy Space Center in Florida to prepare for the arrival of the agency's massive Space Launch System (SLS) core stage aboard the barge Pegasus. A crane will be used to lift up precast concrete poles and position them to be driven to a depth of about 70 feet into the bedrock below the water around the turn basin. The upgrades are necessary to accommodate the 300,000-pound core booster aboard the modified Pegasus barge. The Ground Systems Development and Operations Program is overseeing the upgrades to the turn basin wharf.
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39. Photographic copy of original construction drawing, dated June 1911 ...
39. Photographic copy of original construction drawing, dated June 1911 (from paper-copy of aperture-card negative at Bureau of Reclamation, Pacific Northwest Regional Office, Boise, ID). SECOND FLOOR PLAN. - Boise Project, Boise Project Office, 214 Broadway, Boise, Ada County, ID
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2014-04-14
CAPE CANAVERAL, Fla. -- At Kennedy Space Center's Launch Pad 39A, Gwynne Shotwell, president and chief operating officer of Space Exploration Technologies SpaceX of Hawthorne, Calif., speaks to members of the news media announcing that NASA has just signed a lease agreement with SpaceX for use and operation of Launch Complex 39A. SpaceX will use Launch Complex 39A for rockets such as the Falcon Heavy, currently under development. Both launch pad 39A and 39B were originally built for the Apollo/Saturn V rockets that launched American astronauts on their historic journeys to the moon and later modified to support the 30-year shuttle program. Pad 39B is now being modified by NASA to support the Space Launch System SLS rocket boosting the Orion spacecraft part of the agency’s plan to explore beyond low-Earth orbit. To learn more about Launch Pad 39A visit: http://www.nasa.gov/mission_pages/shuttle/launch/launch-complex39-toc.html Photo credit: NASA/Dan Casper
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2014-04-14
CAPE CANAVERAL, Fla. -- At Kennedy Space Center's Launch Pad 39A, center director Bob Cabana announces that NASA has just signed a lease agreement with Space Exploration Technologies SpaceX of Hawthorne, Calif., for use and operation of Launch Complex 39A. NASA Administrator Charlie Bolden, left, and Gwynne Shotwell, president and chief operating officer of SpaceX, look on. SpaceX will use Launch Complex 39A for rockets such as the Falcon Heavy, currently under development. Both launch pad 39A and 39B were originally built for the Apollo/Saturn V rockets that launched American astronauts on their historic journeys to the moon and later modified to support the 30-year shuttle program. Pad 39B is now being modified by NASA to support the Space Launch System SLS rocket boosting the Orion spacecraft part of the agency’s plan to explore beyond low-Earth orbit. To learn more about Launch Pad 39A visit: http://www.nasa.gov/mission_pages/shuttle/launch/launch-complex39-toc.html Photo credit: NASA/Dan Casper
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2014-04-14
CAPE CANAVERAL, Fla. -- At Kennedy Space Center's Launch Pad 39A, Gwynne Shotwell, president and chief operating officer of Space Exploration Technologies SpaceX of Hawthorne, Calif., announces that NASA has just signed a lease agreement with SpaceX for use and operation of Launch Complex 39A. NASA Administrator Charlie Bolden, left, and Kennedy Space Center Director Bob Cabana listen. SpaceX will use Launch Complex 39A for rockets such as the Falcon Heavy, currently under development. Both launch pad 39A and 39B were originally built for the Apollo/Saturn V rockets that launched American astronauts on their historic journeys to the moon and later modified to support the 30-year shuttle program. Pad 39B is now being modified by NASA to support the Space Launch System SLS rocket boosting the Orion spacecraft part of the agency’s plan to explore beyond low-Earth orbit. To learn more about Launch Pad 39A visit: http://www.nasa.gov/mission_pages/shuttle/launch/launch-complex39-toc.html Photo credit: NASA/Dan Casper
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2001-06-20
KENNEDY SPACE CENTER, Fla. -- An aerial view of Launch Complex 39 shows the south and west sides of the Vehicle Assembly Building. The curved roadway heading to the VAB leads to the high bay 2, the Safe Haven facility constructed in 2000. The white building in the foreground is the Processing Control Center. Beyond it is the Orbiter Processing Facility, bays 1 and 2. The OPF bay 3 is farther still, closer to the VAB. Farther in the background are the waters of Banana Creek in the Merritt Island National Wildlife Refuge
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2017-06-14
Modifications are underway at the Launch Complex 39 turn basin wharf at NASA's Kennedy Space Center in Florida to prepare for the arrival of the agency's massive Space Launch System (SLS) core stage aboard the barge Pegasus. Precast concrete poles are being driven to a depth of about 70 feet into the bedrock below the water around the turn basin; later filled with concrete. The upgrades are necessary to accommodate the increased weight of the core stage along with ground support and transportation equipment aboard the modified barge Pegasus. The Ground Systems Development and Operations Program is overseeing the upgrades to the turn basin wharf.
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DART Support for Hurricane Matthew
2016-10-18
Damaged construction trailers and several pieces of associated debris, aftermath of Hurricane Matthew, are seen in front of the Mobile Launcher in the Launch Complex 39 area at NASA's Kennedy Space Center in Florida. Assessments and repairs are in progress at various structures and facilities across the spaceport, part of the ongoing recovery from Hurricane Matthew, which passed to the east of Kennedy on Oct. 6 and 7, 2016. The center received some isolated roof damage, damaged support buildings, a few downed power lines, and limited water intrusion. Beach erosion also occurred, although the storm surge was less than expected.
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2017-06-14
Modifications are underway at the Launch Complex 39 turn basin wharf at NASA's Kennedy Space Center in Florida to prepare for the arrival of the agency's massive Space Launch System (SLS) core stage aboard the barge Pegasus. Precast concrete poles are being driven to a depth of about 70 feet into the bedrock below the water around the turn basin. The upgrades are necessary to accommodate the increased weight of the core stage along with ground support and transportation equipment aboard the modified barge Pegasus. The Ground Systems Development and Operations Program is overseeing the upgrades to the turn basin wharf.
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14 CFR 33.39 - Lubrication system.
Code of Federal Regulations, 2011 CFR
2011-01-01
... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Lubrication system. 33.39 Section 33.39 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Design and Construction; Reciprocating Aircraft Engines § 33.39 Lubrication...
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14 CFR 33.39 - Lubrication system.
Code of Federal Regulations, 2010 CFR
2010-01-01
... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Lubrication system. 33.39 Section 33.39 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: AIRCRAFT ENGINES Design and Construction; Reciprocating Aircraft Engines § 33.39 Lubrication...
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39. From Final Construction Report on the Haleakala Road ProjectNR7, ...
39. From Final Construction Report on the Haleakala Road Project--NR-7, Hawaii National Park, Island of Maui, Territory of Hawaii, T.H., by Merel S. Sager, Resident Landscape Architect, April 16, 1935. COVERING CONSPICOUS ROCK FILLS WITH SOIL. - Haleakala National Park Roads, Pukalani, Maui County, HI
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Code of Federal Regulations, 2010 CFR
2010-01-01
... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Protection. 31.39 Section 31.39 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: MANNED FREE BALLOONS Design Construction § 31.39 Protection. Each part of the balloon must be...
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25 CFR 39.720 - Why are there different reporting requirements for transportation data?
Code of Federal Regulations, 2014 CFR
2014-04-01
... there different reporting requirements for transportation data? In order to construct an actual cost data base, residential and day schools must report data required by §§ 39.721 and 39.722. ... transportation data? 39.720 Section 39.720 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION...
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25 CFR 39.720 - Why are there different reporting requirements for transportation data?
Code of Federal Regulations, 2011 CFR
2011-04-01
... there different reporting requirements for transportation data? In order to construct an actual cost data base, residential and day schools must report data required by §§ 39.721 and 39.722. ... transportation data? 39.720 Section 39.720 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION...
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25 CFR 39.720 - Why are there different reporting requirements for transportation data?
Code of Federal Regulations, 2012 CFR
2012-04-01
... there different reporting requirements for transportation data? In order to construct an actual cost data base, residential and day schools must report data required by §§ 39.721 and 39.722. ... transportation data? 39.720 Section 39.720 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION...
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25 CFR 39.720 - Why are there different reporting requirements for transportation data?
Code of Federal Regulations, 2013 CFR
2013-04-01
... there different reporting requirements for transportation data? In order to construct an actual cost data base, residential and day schools must report data required by §§ 39.721 and 39.722. ... transportation data? 39.720 Section 39.720 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION...
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25 CFR 39.720 - Why are there different reporting requirements for transportation data?
Code of Federal Regulations, 2010 CFR
2010-04-01
... there different reporting requirements for transportation data? In order to construct an actual cost data base, residential and day schools must report data required by §§ 39.721 and 39.722. ... transportation data? 39.720 Section 39.720 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION...
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Structural Analysis of Lightning Protection System for New Launch Vehicle
NASA Technical Reports Server (NTRS)
Cope, Anne; Moore, Steve; Pruss, Richard
2008-01-01
This project includes the design and specification of a lightning protection system for Launch Complex 39 B (LC39B) at Kennedy Space Center, FL in support of the Constellation Program. The purpose of the lightning protection system is to protect the Crew Launch Vehicle (CLV) or Cargo Launch Vehicle (CaLV) and associated launch equipment from direct lightning strikes during launch processing and other activities prior to flight. The design includes a three-tower, overhead catenary wire system to protect the vehicle and equipment on LC39B as described in the study that preceded this design effort: KSC-DX-8234 "Study: Construct Lightning Protection System LC3 9B". The study was a collaborative effort between Reynolds, Smith, and Hills (RS&H) and ASRC Aerospace (ASRC), where ASRC was responsible for the theoretical design and risk analysis of the lightning protection system and RS&H was responsible for the development of the civil and structural components; the mechanical systems; the electrical and grounding systems; and the siting of the lightning protection system. The study determined that a triangular network of overhead catenary cables and down conductors supported by three triangular free-standing towers approximately 594 ft tall (each equipped with a man lift, ladder, electrical systems, and communications systems) would provide a level of lightning protection for the Constellation Program CLV and CaLV on Launch Pad 39B that exceeds the design requirements.
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Photocopy of drawing. LAUNCH COMPLEX 39. NASA, John F. Kennedy ...
Photocopy of drawing. LAUNCH COMPLEX 39. NASA, John F. Kennedy Space Center, Florida. File Number 203-100, Urbahn-Roberts-Seelye-Moran, October, 1963. LCC TRANSVERSE SECTIONS AA & BB. Sheet 29-45 - Cape Canaveral Air Force Station, Launch Complex 39, Launch Control Center, LCC Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL
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Photocopy of drawing. LAUNCH COMPLEX 39, CRAWLER TRANSPORTER. NASA, John ...
Photocopy of drawing. LAUNCH COMPLEX 39, CRAWLER TRANSPORTER. NASA, John F. Kennedy Space Center, Florida. Drawing 75M05760, KSC-Launch Support Equipment Engineering Division, January 1967. GENERAL ARRANGEMENT. Sheet 1 of 4 - Cape Canaveral Air Force Station, Launch Complex 39, Crawler Transporters, Launcher Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL
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NASA Technical Reports Server (NTRS)
2005-01-01
KENNEDY SPACE CENTER, FLA. At Launch Complex 39B, technicians construct a platform in Space Shuttle Discovery's payload bay to support an upcoming borescope inspection of the retract link assembly on the orbiter's main landing gear door. The inspection is a precautionary measure after a small crack was found in a retract link assembly on the right-hand main landing gear on orbiter Atlantis. An initial review of the closeout photos of the link assembly on Discovery did not reveal any cracks. Discovery is scheduled to return the Space Shuttle fleet to operational status on mission STS-114. This additional work does not impact the launch planning window of July 13-31.
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NASA Technical Reports Server (NTRS)
2005-01-01
KENNEDY SPACE CENTER, FLA. At Launch Complex 39B, technicians construct a platform in Space Shuttle Discovery's payload bay to support an upcoming borescope inspection of the retract link assembly on the orbiter's main landing gear door. The inspection is a precautionary measure after a small crack was found in a retract link assembly on the right-hand main landing gear on orbiter Atlantis. An initial review of the closeout photos of the link assembly on Discovery did not reveal any cracks. Discovery is scheduled to return the Space Shuttle fleet to operational status on mission STS-114. This additional work does not impact the launch planning window of July 13-31.
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NASA Technical Reports Server (NTRS)
2005-01-01
KENNEDY SPACE CENTER, FLA. At Launch Complex 39B, technicians construct a platform in Space Shuttle Discovery's payload bay to support an upcoming borescope inspection of the retract link assembly on the orbiter's main landing gear door. The inspection is a precautionary measure after a small crack was found in a retract link assembly on the right-hand main landing gear on orbiter Atlantis. An initial review of the closeout photos of the link assembly on Discovery did not reveal any cracks. Discovery is scheduled to return the Space Shuttle fleet to operational status on mission STS-114. This additional work does not impact the launch planning window of July 13-31.
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2010-09-20
CAPE CANAVERAL, Fla. - Workers of Superior Solar LLC in Longwood, Fla., begin to install more than 300 solar panels on the roof of the Propellants North Administrative and Maintenance Facility at NASA's Kennedy Space Center in Florida. Each panel, built in Sharp Corp.'s Memphis, Tenn., plant, will produce 235 watts of clean energy. The green facility in Kennedy's Launch Complex 39 area will have a two-story administrative building to house managers, mechanics and technicians who fuel spacecraft at Kennedy adjacent to a single-story shop to store cryogenic fuel transfer equipment. The facility is striving to qualify for the U.S. Green Building Council’s Leadership in Energy and Environmental Design (LEED) Platinum certification. If successful, it will be the first NASA facility to achieve this highest of LEED ratings after it is completed. The facility was designed for NASA by Jones Edmunds and Associates. H. W. Davis Construction is the construction contractor. Photo credit: NASA/Jim Grossmann
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2010-09-20
CAPE CANAVERAL, Fla. - Workers of Superior Solar LLC in Longwood, Fla., begin to install more than 300 solar panels on the roof of the Propellants North Administrative and Maintenance Facility at NASA's Kennedy Space Center in Florida. Each panel, built in Sharp Corp.'s Memphis, Tenn., plant, will produce 235 watts of clean energy. The green facility in Kennedy's Launch Complex 39 area will have a two-story administrative building to house managers, mechanics and technicians who fuel spacecraft at Kennedy adjacent to a single-story shop to store cryogenic fuel transfer equipment. The facility is striving to qualify for the U.S. Green Building Council’s Leadership in Energy and Environmental Design (LEED) Platinum certification. If successful, it will be the first NASA facility to achieve this highest of LEED ratings after it is completed. The facility was designed for NASA by Jones Edmunds and Associates. H. W. Davis Construction is the construction contractor. Photo credit: NASA/Jim Grossmann
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2010-09-20
CAPE CANAVERAL, Fla. - Workers of Superior Solar LLC in Longwood, Fla., prepare to install more than 300 solar panels on the roof of the Propellants North Administrative and Maintenance Facility at NASA's Kennedy Space Center in Florida. Each panel, built in Sharp Corp.'s Memphis, Tenn., plant, will produce 235 watts of clean energy. The green facility in Kennedy's Launch Complex 39 area will have a two-story administrative building to house managers, mechanics and technicians who fuel spacecraft at Kennedy adjacent to a single-story shop to store cryogenic fuel transfer equipment. The facility is striving to qualify for the U.S. Green Building Council’s Leadership in Energy and Environmental Design (LEED) Platinum certification. If successful, it will be the first NASA facility to achieve this highest of LEED ratings after it is completed. The facility was designed for NASA by Jones Edmunds and Associates. H. W. Davis Construction is the construction contractor. Photo credit: NASA/Jim Grossmann
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2010-09-20
CAPE CANAVERAL, Fla. - Workers of Superior Solar LLC in Longwood, Fla., begin to install more than 300 solar panels on the roof of the Propellants North Administrative and Maintenance Facility at NASA's Kennedy Space Center in Florida. Each panel, built in Sharp Corp.'s Memphis, Tenn., plant, will produce 235 watts of clean energy. The green facility in Kennedy's Launch Complex 39 area will have a two-story administrative building to house managers, mechanics and technicians who fuel spacecraft at Kennedy adjacent to a single-story shop to store cryogenic fuel transfer equipment. The facility is striving to qualify for the U.S. Green Building Council’s Leadership in Energy and Environmental Design (LEED) Platinum certification. If successful, it will be the first NASA facility to achieve this highest of LEED ratings after it is completed. The facility was designed for NASA by Jones Edmunds and Associates. H. W. Davis Construction is the construction contractor. Photo credit: NASA/Jim Grossmann
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Cape Canaveral Air Force Station, Launch Complex 39, Solid Rocket ...
Cape Canaveral Air Force Station, Launch Complex 39, Solid Rocket Booster Disassembly & Refurbishment Complex, Thrust Vector Control Deservicing Facility, Hangar Road, Cape Canaveral, Brevard County, FL
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model that was on display at the NASA Kennedy Space Center Visitor Complex in Florida travels northbound along Kennedy Parkway toward NASA Kennedy Space Center's Launch Complex 39 turn basin. It is standard procedure for large payloads and equipment to travel against the normal flow of traffic under the supervision of a move crew when being transported on or off center property. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – Support personnel pose for a group portrait with the high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida. The shuttle lingered momentarily in the parking lot entrance to its destination, Kennedy's Launch Complex 39 turn basin. Behind them are the 525-foot-tall Vehicle Assembly Building and the Launch Control Center (at right). The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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Kumari, Amrita; Koyama, Tetsuo; Hatano, Ken; Matsuoka, Koji
2016-10-01
A tetravalent GlcNAc pendant glycocluster was constructed with terminal biotin through C6 linker. To acquire the multivalent carbohydrate-protein interactions, we synthesized a glycopolymer of tetrameric structure using N-acetyl-d-glucosamine (GlcNAc) as the target carbohydrate by the use of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM) as coupling reagent, followed by biotin-avidin complexation leading to the formation of glycocluster of avidin-biotin-GlcNAc conjugate (ABG complex). The dynamic light scattering (DLS) system was implied for size detection and to check the binding affinity of GlcNAc conjugate with a WGA lectin we use fluorometric assay by means of specific excitation of tryptophan at λex 295nm and it was found to be very high Ka∼1.39×10(7) M(-1) in case of ABG complex as compared to GlcNAc only Ka∼1.01×10(4) M(-1) with the phenomenon proven to be due to glycocluster effect. Copyright © 2016 Elsevier Inc. All rights reserved.
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2011-12-12
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida has arrived at Kennedy's Launch Complex 39 turn basin and awaits preparation for the next leg of its journey. Across the street, the Vehicle Assembly Building towers 525 feet into the sky. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Jim Grossmann
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida arrives at Kennedy's Launch Complex 39 turn basin where it will be prepared for the next leg of its journey. Across the street, the Vehicle Assembly Building towers 525 feet into the sky. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – Support personnel plan the last leg of the move of the high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida to Kennedy's Launch Complex 39 turn basin. Across the street (at right) are the 525-foot-tall Vehicle Assembly Building and the Launch Control Center. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-12
CAPE CANAVERAL, Fla. – Wheels are installed on the high-fidelity space shuttle model following its arrival at Kennedy's Launch Complex 39 turn basin in Florida. The model was on display at the NASA Kennedy Space Center Visitor Complex until recently. In the distance, from left, are the Operations Support Building II, the Operations Support Building I, and the 525-foot-tall Vehicle Assembly Building. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Jim Grossmann
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2011-12-11
CAPE CANAVERAL, Fla. – Support personnel walk with the high-fidelity space shuttle model which was on display at the NASA Kennedy Space Center Visitor Complex in Florida as it rolls through the parking lot leading to Kennedy's Launch Complex 39 turn basin. Behind it are the 525-foot-tall Vehicle Assembly Building and the Launch Control Center. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2017-06-14
Modifications are underway at the Launch Complex 39 turn basin wharf at NASA's Kennedy Space Center in Florida to prepare for the arrival of the agency's massive Space Launch System (SLS) core stage aboard the barge Pegasus. Equipment is staged and a crane will be used to lift up precast concrete poles and position them to be driven to a depth of about 70 feet into the bedrock below the water around the turn basin. The upgrades are necessary to accommodate the increased weight of the core stage along with ground support and transportation equipment aboard the modified barge Pegasus. The Ground Systems Development and Operations Program is overseeing the upgrades to the turn basin wharf.
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2017-06-14
Modifications are underway at the Launch Complex 39 turn basin wharf at NASA's Kennedy Space Center in Florida to prepare for the arrival of the agency's massive Space Launch System (SLS) core stage aboard the barge Pegasus. A crane will be used to lift up precast concrete poles and position them to be driven to a depth of about 70 feet into the bedrock below the water around the turn basin. The upgrades are necessary to accommodate the increased weight of the core stage along with ground support and transportation equipment aboard the modified barge Pegasus. The Ground Systems Development and Operations Program is overseeing the upgrades to the turn basin wharf.
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46 CFR 162.050-39 - Measurement of oil content.
Code of Federal Regulations, 2010 CFR
2010-10-01
... 46 Shipping 6 2010-10-01 2010-10-01 false Measurement of oil content. 162.050-39 Section 162.050-39 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Pollution Prevention Equipment § 162.050-39...
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Photocopy of drawing. LAUNCH COMPLEX 39. NASA John F. Kennedy ...
Photocopy of drawing. LAUNCH COMPLEX 39. NASA John F. Kennedy Space Center, Florida. File Number 203-100, Urbahn-Roberts-Seelye-Moran, October 1963. VERTICAL ASSEMBLY BUILDING, LOW BAY, SECTIONS J-J, K-K, & L-L. Sheet 33-32 - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL
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Photocopy of drawing. LAUNCH COMPLEX 39. NASA, John F. Kennedy ...
Photocopy of drawing. LAUNCH COMPLEX 39. NASA, John F. Kennedy Space Center, Florida. File Number 203-100, Urbahn-Roberts-Seelye-Moran, October, 1963. VOLUME 29, LAUNCH CONTROL CENTER (LCC) TITLE AND LOCATION SHEET. Sheet 29-01 - Cape Canaveral Air Force Station, Launch Complex 39, Launch Control Center, LCC Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL
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2011-12-11
CAPE CANAVERAL, Fla. – A transporter carrying the high-fidelity space shuttle model that was on display at the NASA Kennedy Space Center Visitor Complex in Florida rolls along the NASA Causeway as it leaves the visitor complex on its way to NASA Kennedy Space Center's Launch Complex 39 turn basin. It is standard procedure for large payloads and equipment to travel against the normal flow of traffic under the supervision of a move crew when being transported on or off center property. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2014-06-11
CAPE CANAVERAL, Fla. -- Modifications continue on the Mobile Launcher, or ML, at the Mobile Launcher Park Site at NASA’s Kennedy Space Center in Florida. In a view looking down from the top of the ML is the base of the ML and various facilities in the Launch Complex 39 area. The ML is being modified and strengthened to accommodate the weight, size and thrust at launch of NASA's Space Launch System, or SLS, and Orion spacecraft. In 2013, the agency awarded a contract to J.P. Donovan Construction Inc. of Rockledge, Fla., to modify the ML, which is one of the key elements of ground support equipment that is being upgraded by the Ground Systems Development and Operations Program office at Kennedy. The existing 24-foot exhaust hole is being enlarged and strengthened for the larger, heavier SLS rocket. The ML will carry the SLS rocket and Orion spacecraft to Launch Pad 39B for its first mission, Exploration Mission-1, in 2017. Photo credit: NASA/Daniel Casper
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model that was on display at the NASA Kennedy Space Center Visitor Complex in Florida nears the intersection of NASA Causeway and Kennedy Parkway. It is standard procedure for large payloads and equipment to travel against the normal flow of traffic under the supervision of a move crew when being transported on or off center property. The model is being moved from the visitor complex to NASA Kennedy Space Center's Launch Complex 39 turn basin. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-02-08
CAPE CANAVERAL, Fla. -- A traditional ribbon-cutting ceremony takes place inside the new 18,500-square-foot Electrical Maintenance Facility (EMF) at NASA's Kennedy Space Center in Florida. From left are Kennedy Director of Operations Mike Benik, NASA Construction of Facility Project Manager Nick Rivieccio and Kennedy Center Director Bob Cabana. Located in Kennedy's Launch Complex 39 area, the EMF will provide new and renovated space for maintenance shops, offices, and equipment and material storage in support of the electrical maintenance functions for the center. The facility is projected to receive Gold certification under the U.S. Green Building Council’s Leadership in Energy and Environmental Design (LEED) rating system. Photo credit: NASA/ Troy Cryder
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Guo, Liwei; Zhang, Yikun; Ma, Mengqi; Liu, Qiang; Zhang, Yanan; Peng, Youliang; Liu, Junfeng
2018-04-01
RGA5 is a component of the Pia resistance-protein pair (RGA4/RGA5) from Oryza sativa L. japonica. It acts as an immune receptor that directly recognizes the effector AVR1-CO39 from Magnaporthe oryzae via a C-terminal non-LRR domain (RGA5A_S). The interaction between RGA5A_S and AVR1-CO39 relieves the repression of RGA4, leading to effector-independent cell death. To determine the structure of the complex of RGA5A_S and AVR1-CO39 and to understand the details of this interaction, the complex was prepared by fusing the proteins together, by mixing them in vitro or by co-expressing them in one host cell. Samples purified via the first two strategies were crystallized under two different conditions. A mixture of AVR1-CO39 and RGA5A_S (complex I) crystallized in 1.1 M ammonium tartrate dibasic, 0.1 M sodium acetate-HCl pH 4.6, while crystals of the fusion complex RGA5A_S-TEV-AVR1-CO39 (complex II) were grown in 2 M NaCl. The crystal of complex I belonged to space group P3 1 21, with unit-cell parameters a = b = 66.2, c = 108.8 Å, α = β = 90, γ = 120°. The crystals diffracted to a Bragg spacing of 2.4 Å, and one molecule each of RGA5A_S and AVR1-CO39 were present in the asymmetric unit of the initial model. The crystal of complex II belonged to space group I4, with unit-cell parameters a = b = 137.4, c = 66.2 Å, α = β = γ = 90°. The crystals diffracted to a Bragg spacing of 2.72 Å, and there were two molecules of RGA5A_S and two molecules of AVR1-CO39 in the asymmetric unit of the initial model. Further structural characterization of the interaction between RGA5A_S and AVR1-CO39 will lead to a better understanding of the mechanism underlying effector recognition by R proteins.
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2014-06-11
CAPE CANAVERAL, Fla. -- Modifications continue on the Mobile Launcher, or ML, at the Mobile Launcher Park Site at NASA’s Kennedy Space Center in Florida. In view from the top of the ML is the Vehicle Assembly Building, the Launch Control Center at left and various other facilities in the Launch Complex 39 area. The ML is being modified and strengthened to accommodate the weight, size and thrust at launch of NASA's Space Launch System, or SLS, and Orion spacecraft. In 2013, the agency awarded a contract to J.P. Donovan Construction Inc. of Rockledge, Fla., to modify the ML, which is one of the key elements of ground support equipment that is being upgraded by the Ground Systems Development and Operations Program office at Kennedy. The existing 24-foot exhaust hole is being enlarged and strengthened for the larger, heavier SLS rocket. The ML will carry the SLS rocket and Orion spacecraft to Launch Pad 39B for its first mission, Exploration Mission-1, in 2017. Photo credit: NASA/Daniel Casper
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2014-06-11
CAPE CANAVERAL, Fla. -- Modifications continue on the Mobile Launcher, or ML, at the Mobile Launcher Park Site at NASA’s Kennedy Space Center in Florida. In view from the top of the ML is the Vehicle Assembly Building, the Launch Control Center at left and various other facilities in the Launch Complex 39 area. The ML is being modified and strengthened to accommodate the weight, size and thrust at launch of NASA's Space Launch System, or SLS, and Orion spacecraft. In 2013, the agency awarded a contract to J.P. Donovan Construction Inc. of Rockledge, Fla., to modify the ML, which is one of the key elements of ground support equipment that is being upgraded by the Ground Systems Development and Operations Program office at Kennedy. The existing 24-foot exhaust hole is being enlarged and strengthened for the larger, heavier SLS rocket. The ML will carry the SLS rocket and Orion spacecraft to Launch Pad 39B for its first mission, Exploration Mission-1, in 2017. Photo credit: NASA/Daniel Casper
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Lin, Chi-Hung; Jarvis, Donald L
2013-05-10
Genetically transformed lepidopteran insect cell lines have biotechnological applications as constitutive recombinant protein production platforms and improved hosts for baculovirus-mediated recombinant protein production. Insect cell transformation is often accomplished with a DNA construct(s) encoding a foreign protein(s) under the transcriptional control of a baculovirus immediate early promoter, such as the ie1 promoter. However, the potential utility of increasingly stronger promoters from later baculovirus gene classes, such as delayed early (39K), late (p6.9), and very late (polh), has not been systematically assessed. Hence, we produced DNA constructs encoding secreted alkaline phosphatase (SEAP) under the transcriptional control of each of the four temporally distinct classes of baculovirus promoters, used them to transform insect cells, and compared the levels of SEAP RNA and protein production obtained before and after baculovirus infection. The ie1 construct was the only one that supported SEAP protein production by transformed insect cells prior to baculovirus infection, confirming that only immediate early promoters can be used to isolate transformed insect cells for constitutive recombinant protein production. However, baculovirus infection activated transgene expression by all four classes of baculovirus promoters. After infection, cells transformed with the very late (polh) and late (p6.9) promoter constructs produced the highest levels of SEAP RNA, but only low levels of SEAP protein. Conversely, cells transformed with the immediate early (ie1) and delayed early (39K) promoter constructs produced lower levels of RNA, but equal or higher levels of SEAP protein. Unexpectedly, the 39K promoter construct provided tightly regulated, baculovirus-inducible protein production at higher levels than the later promoter constructs. Thus, this study demonstrated the utility of the 39K promoter for insect cell engineering, particularly when one requires higher levels of effector protein production than obtained with ie1 and/or when constitutive transgene expression adversely impacts host cell fitness and/or genetic stability. Copyright © 2013 Elsevier B.V. All rights reserved.
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46 CFR 162.050-39 - Measurement of oil content.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 46 Shipping 6 2012-10-01 2012-10-01 false Measurement of oil content. 162.050-39 Section 162.050-39 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL ENGINEERING EQUIPMENT Pollution Prevention Equipment § 162.050-39 Measurement of oil content. The collection and...
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Code of Federal Regulations, 2012 CFR
2012-07-01
... STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection... facility actions located in a wetland: (1) New construction, owned or leased; or (2) Construction projects..., interpretation, or enjoyment of wetland resources; (2) Construction at existing postal facilities pursuant to the...
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Code of Federal Regulations, 2014 CFR
2014-07-01
... STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection... facility actions located in a wetland: (1) New construction, owned or leased; or (2) Construction projects..., interpretation, or enjoyment of wetland resources; (2) Construction at existing postal facilities pursuant to the...
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Code of Federal Regulations, 2011 CFR
2011-07-01
... STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection... facility actions located in a wetland: (1) New construction, owned or leased; or (2) Construction projects..., interpretation, or enjoyment of wetland resources; (2) Construction at existing postal facilities pursuant to the...
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Code of Federal Regulations, 2013 CFR
2013-07-01
... STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection... facility actions located in a wetland: (1) New construction, owned or leased; or (2) Construction projects..., interpretation, or enjoyment of wetland resources; (2) Construction at existing postal facilities pursuant to the...
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Proof Constructions and Evaluations
ERIC Educational Resources Information Center
Stylianides, Andreas J.; Stylianides, Gabriel J.
2009-01-01
In this article, we focus on a group of 39 prospective elementary (grades K-6) teachers who had rich experiences with proof, and we examine their ability to construct proofs and evaluate their own constructions. We claim that the combined "construction-evaluation" activity helps illuminate certain aspects of prospective teachers' and presumably…
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Rational Design of a Triple Reporter Gene for Multimodality Molecular Imaging
Hsieh, Ya-Ju; Ke, Chien-Chih; Yeh, Skye Hsin-Hsien; Lin, Chien-Feng; Chen, Fu-Du; Lin, Kang-Ping; Chen, Ran-Chou; Liu, Ren-Shyan
2014-01-01
Multimodality imaging using noncytotoxic triple fusion (TF) reporter genes is an important application for cell-based tracking, drug screening, and therapy. The firefly luciferase (fl), monomeric red fluorescence protein (mrfp), and truncated herpes simplex virus type 1 thymidine kinase SR39 mutant (ttksr39) were fused together to create TF reporter gene constructs with different order. The enzymatic activities of TF protein in vitro and in vivo were determined by luciferase reporter assay, H-FEAU cellular uptake experiment, bioluminescence imaging, and micropositron emission tomography (microPET). The TF construct expressed in H1299 cells possesses luciferase activity and red fluorescence. The tTKSR39 activity is preserved in TF protein and mediates high levels of H-FEAU accumulation and significant cell death from ganciclovir (GCV) prodrug activation. In living animals, the luciferase and tTKSR39 activities of TF protein have also been successfully validated by multimodality imaging systems. The red fluorescence signal is relatively weak for in vivo imaging but may expedite FACS-based selection of TF reporter expressing cells. We have developed an optimized triple fusion reporter construct DsRedm-fl-ttksr39 for more effective and sensitive in vivo animal imaging using fluorescence, bioluminescence, and PET imaging modalities, which may facilitate different fields of biomedical research and applications. PMID:24809057
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Perelman, Polina L; Pichler, Rudolf; Gaggl, Anna; Larkin, Denis M; Raudsepp, Terje; Alshanbari, Fahad; Holl, Heather M; Brooks, Samantha A; Burger, Pamela A; Periasamy, Kathiravan
2018-01-31
The availability of genomic resources including linkage information for camelids has been very limited. Here, we describe the construction of a set of two radiation hybrid (RH) panels (5000 RAD and 15000 RAD ) for the dromedary (Camelus dromedarius) as a permanent genetic resource for camel genome researchers worldwide. For the 5000 RAD panel, a total of 245 female camel-hamster radiation hybrid clones were collected, of which 186 were screened with 44 custom designed marker loci distributed throughout camel genome. The overall mean retention frequency (RF) of the final set of 93 hybrids was 47.7%. For the 15000 RAD panel, 238 male dromedary-hamster radiation hybrid clones were collected, of which 93 were tested using 44 PCR markers. The final set of 90 clones had a mean RF of 39.9%. This 15000 RAD panel is an important high-resolution complement to the main 5000 RAD panel and an indispensable tool for resolving complex genomic regions. This valuable genetic resource of dromedary RH panels is expected to be instrumental for constructing a high resolution camel genome map. Construction of the set of RH panels is essential step toward chromosome level reference quality genome assembly that is critical for advancing camelid genomics and the development of custom genomic tools.
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Construction of a 3-arcsecond digital elevation model for the Gulf of Maine
Twomey, Erin R.; Signell, Richard P.
2013-01-01
A system-wide description of the seafloor topography is a basic requirement for most coastal oceanographic studies. The necessary detail of the topography obviously varies with application, but for many uses, a nominal resolution of roughly 100 m is sufficient. Creating a digital bathymetric grid with this level of resolution can be a complex procedure due to a multiplicity of data sources, data coverages, datums and interpolation procedures. This report documents the procedures used to construct a 3-arcsecond (approximately 90-meter grid cell size) digital elevation model for the Gulf of Maine (71°30' to 63° W, 39°30' to 46° N). We obtained elevation and bathymetric data from a variety of American and Canadian sources, converted all data to the North American Datum of 1983 for horizontal coordinates and the North American Vertical Datum of 1988 for vertical coordinates, used a combination of automatic and manual techniques for quality control, and interpolated gaps using a surface-fitting routine.
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Code of Federal Regulations, 2010 CFR
2010-07-01
... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Hose conduit. 18.39 Section 18.39 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction and Design Requirements...
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CCP Astronauts at LC 39A and SpaceX Recovery Ship
2018-03-28
Commercial Crew Astronauts Bob Behnken , Eric Boe, Doug Hurley, and Suni Williams survey SpaceX's progress at Launch Complex 39 A. The survey helped ensure the was familiar with the launch complex and recovery ship prior to missions to station.
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CW Measurement System. Software System Maintenance Manual.
1982-04-02
37 2-7 Amplitude of Transformed Input Wave ............. 39 6-1 Flowchart of the IF-THEN-ELSE Construct ...... 99 6-2 Flowchart of FOR...Construct ................... 100 6-3 Flowchart of REPEAT Construct ................ 101 6-4 Flowchart of WHILE Construct ................. 102 6-5... Flowchart of CASEOF Construct ................ 103 6-6 Flowchart of PROCEDURE Construct ................ 104 6-7 Flowchart of PROGRAM Construct
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model that was on display at the NASA Kennedy Space Center Visitor Complex in Florida negotiates the turn from Kennedy Parkway onto Schwartz Road on its way toward NASA Kennedy Space Center's Launch Complex 39 turn basin. It is standard procedure for large payloads and equipment to travel against the normal flow of traffic under the supervision of a move crew when being transported on or off center property. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model that was on display at the NASA Kennedy Space Center Visitor Complex in Florida moves past the traffic signals onto Kennedy Parkway as it travels northbound toward NASA Kennedy Space Center's Launch Complex 39 turn basin. It is standard procedure for large payloads and equipment to travel against the normal flow of traffic under the supervision of a move crew when being transported on or off center property. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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Construct Validity of Neuropsychological Tests in Schizophrenia.
ERIC Educational Resources Information Center
Allen, Daniel N.; Aldarondo, Felito; Goldstein, Gerald; Huegel, Stephen G.; Gilbertson, Mark; van Kammen, Daniel P.
1998-01-01
The construct validity of neuropsychological tests in patients with schizophrenia was studied with 39 patients who were evaluated with a battery of six tests assessing attention, memory, and abstract reasoning abilities. Results support the construct validity of the neuropsychological tests in patients with schizophrenia. (SLD)
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Stepanyuk, Galina A.; Serrano, Pedro; Peralta, Eigen
RNA-binding protein 39 (RBM39) is a splicing factor and a transcriptional co-activator of estrogen receptors and Jun/AP-1, and its function has been associated with malignant progression in a number of cancers. The C-terminal RRM domain of RBM39 belongs to the U2AF homology motif family (UHM), which mediate protein–protein interactions through a short tryptophan-containing peptide known as the UHM-ligand motif (ULM). Here, crystal and solution NMR structures of the RBM39-UHM domain, and the crystal structure of its complex with U2AF65-ULM, are reported. The RBM39–U2AF65 interaction was confirmed by co-immunoprecipitation from human cell extracts, by isothermal titration calorimetry and by NMR chemicalmore » shift perturbation experiments with the purified proteins. When compared with related complexes, such as U2AF35–U2AF65 and RBM39–SF3b155, the RBM39-UHM–U2AF65-ULM complex reveals both common and discriminating recognition elements in the UHM–ULM binding interface, providing a rationale for the known specificity of UHM–ULM interactions. This study therefore establishes a structural basis for specific UHM–ULM interactions by splicing factors such as U2AF35, U2AF65, RBM39 and SF3b155, and a platform for continued studies of intermolecular interactions governing disease-related alternative splicing in eukaryotic cells.« less
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2011-12-11
CAPE CANAVERAL, Fla. – The transporter carrying the high-fidelity space shuttle model that was on display at the NASA Kennedy Space Center Visitor Complex in Florida makes a wide turn into the right-hand lane of the NASA Causeway as it leaves the visitor complex on its way to NASA Kennedy Space Center's Launch Complex 39 turn basin. It is standard procedure for large payloads and equipment to travel against the normal flow of traffic under the supervision of a move crew when being transported on or off center property. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model that was on display at the NASA Kennedy Space Center Visitor Complex in Florida negotiates the on-ramp at the intersection of NASA Causeway and Kennedy Parkway to gain entrance to the northbound roadways on the center. It is standard procedure for large payloads and equipment to travel against the normal flow of traffic under the supervision of a move crew when being transported on or off center property. The model is being moved from the visitor complex to NASA Kennedy Space Center's Launch Complex 39 turn basin. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model that was on display at the NASA Kennedy Space Center Visitor Complex in Florida arrives at the foot of the on-ramp at the intersection of NASA Causeway and Kennedy Parkway to gain entrance to the northbound roadways on the center. It is standard procedure for large payloads and equipment to travel against the normal flow of traffic under the supervision of a move crew when being transported on or off center property. The model is being moved from the visitor complex to NASA Kennedy Space Center's Launch Complex 39 turn basin. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model that was on display at the NASA Kennedy Space Center Visitor Complex in Florida moves along the on-ramp from NASA Causeway to Kennedy Parkway to gain entrance to the northbound roadways on the center. It is standard procedure for large payloads and equipment to travel against the normal flow of traffic under the supervision of a move crew when being transported on or off center property. The model is being moved from the visitor complex to NASA Kennedy Space Center's Launch Complex 39 turn basin. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model that was on display at the NASA Kennedy Space Center Visitor Complex in Florida uses the on-ramp at the intersection of NASA Causeway and Kennedy Parkway to gain entrance to the northbound roadways on the center. It is standard procedure for large payloads and equipment to travel against the normal flow of traffic under the supervision of a move crew when being transported on or off center property. The model is being moved from the visitor complex to NASA Kennedy Space Center's Launch Complex 39 turn basin. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model that was on display at the NASA Kennedy Space Center Visitor Complex in Florida monopolizes the on-ramp at the intersection of NASA Causeway and Kennedy Parkway to gain entrance to the northbound roadways on the center. It is standard procedure for large payloads and equipment to travel against the normal flow of traffic under the supervision of a move crew when being transported on or off center property. The model is being moved from the visitor complex to NASA Kennedy Space Center's Launch Complex 39 turn basin. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model that was on display at the NASA Kennedy Space Center Visitor Complex in Florida creeps along the on-ramp from NASA Causeway to Kennedy Parkway to gain entrance to the northbound roadways on the center. It is standard procedure for large payloads and equipment to travel against the normal flow of traffic under the supervision of a move crew when being transported on or off center property. The model is being moved from the visitor complex to NASA Kennedy Space Center's Launch Complex 39 turn basin. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – Once it has passed the security gate, the high-fidelity space shuttle model that was on display at the NASA Kennedy Space Center Visitor Complex in Florida changes lanes as it rolls onto the center. It is standard procedure for large payloads and equipment to travel against the normal flow of traffic under the supervision of a move crew when being transported on or off center property. The model is being moved from the visitor complex to NASA Kennedy Space Center's Launch Complex 39 turn basin. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-10-04
CAPE CANAVERAL, Fla. -- Members of the crawlerway system evaluation team pose for a group portrait in front of the Headquarters Building at NASA's Kennedy Space Center in Florida. The team received the Florida Project of the Year award from the American Society of Civil Engineers (ASCE). The Cape Canaveral branch of the ASCE nominated the team for its project, the Crawlerway Evaluation to Support a Heavy-Lift Program. The crawlerway is a 130-foot-wide, specialty-built roadway between Kennedy's Vehicle Assembly Building (VAB), where rockets and spacecraft are prepared for flight, and Launch Pad 39A and 39B. The team's more than two-year evaluation confirmed the crawlerway system would be able to support the weight of moving the agency's future heavy-lift rockets and potential commercial vehicles from the VAB to the launch pads. The award honors the team's outstanding engineering efforts in research, design, construction and management, recognizing the complexity of multi-agency coordination and cost-effective engineering advances. For more information on the American Society of Civil Engineers, visit: http://www.asce.org. Photo credit: NASA/Kim Shiflett
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A Review of Enterprise Architecture Use in Defence
2014-09-01
dictionary of terms; • architecture description language; • architectural information (pertaining both to specific projects and higher level...UNCLASSIFIED 59 Z39.19 2005 Monolingual Controlled Vocabularies, National Information Standards Organisation, Bethesda: NISO Press, 2005. BABOK 2009...togaf/ Z39.19 2005 ANSI/NISO Z39.19 – Guidelines for the Construction, Format, and Management of Monolingual Controlled Vocabularies, Bethesda: NISO
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Cape Canaveral Air Force Station, Launch Complex 39, The Solid ...
Cape Canaveral Air Force Station, Launch Complex 39, The Solid Rocket Booster Assembly and Refurbishment Facility Manufacturing Building, Southeast corner of Schwartz Road and Contractors Road, Cape Canaveral, Brevard County, FL
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Matos Gonçalves, Marta; Pinho, Maria Salomé; Simões, Mário R
2018-03-01
We aimed to analyze the construct and concurrent validity of the Rapid Visual Information Processing (RVP), Paired Associates Learning (PAL), Reaction Time (RTI), and Spatial Working Memory (SWM) tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB®). Inclusion criteria were checked in a first session. The CANTAB and additional pencil-and-paper tests were administered within 1 week. The participants (aged 69-96 years) were 137 Portuguese adults without neuropsychiatric diagnoses and 37 adults with mild-to-moderate Alzheimer's disease dementia. Comparisons were made between the CANTAB tests and between these tests and the Rey Complex Figure Test (RCFT), Verbal Fluency (VF) test, and some Wechsler Memory Scale-III and Wechsler Adult Intelligence Scale-III subtests. Most intra-test correlations were stronger than the CANTAB inter-test correlations. The RVP correlated more with VF animals (.44), the PAL with RCFT immediate recall (-.52), the RTI with RVP mean latency (.42), and the SWM with Spatial Span backward (-.39).
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2001-07-26
KENNEDY SPACE CENTER, FLA. -- Day in the Life page 2. Preparing the pad. Workers maintain Pad A at Kennedy Space Center’s Launch Complex 39. Robert Lust of IVEY Construction pauses on his way to install a safety handrail. This photograph was taken for a special color edition of Spaceport News designed to portray in photographs a single day at KSC, July 26, 2000. The special edition, published Aug. 25, 2000, was created to give readers a look at KSC’s diverse workforce and the critical roles workers play in the nation’s space program. Spaceport News is an official publication of the Kennedy Space Center and is published on alternate Fridays by the Public Affairs Office in the interest of KSC civil service and contractor employees
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45 CFR 63.39 - Religious worship or instruction.
Code of Federal Regulations, 2010 CFR
2010-10-01
... ADMINISTERED BY THE OFFICE OF THE ASSISTANT SECRETARY FOR PLANNING AND EVALUATION Special Provisions § 63.39... religious worship or instruction, or for the construction, operation, or maintenance of so much of any...
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Li, Bing; Liu, Luping; Li, Ying; Dong, Xin; Zhang, Haifeng; Chen, Huaigu; Zheng, Xiaobo; Zhang, Zhengguang
2017-05-01
Vesicle trafficking is an important event in eukaryotic organisms. Many proteins and lipids transported between different organelles or compartments are essential for survival. These processes are mediated by soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins, Rab-GTPases, and multisubunit tethering complexes such as class C core vacuole or endosome tethering and homotypic fusion or vacuole protein sorting (HOPS). Our previous study has demonstrated that FgVam7, which encodes a SNARE protein involving in vesicle trafficking, plays crucial roles in growth, asexual or sexual development, deoxynivalenol production, and pathogenicity in Fusarium graminearum. Here, the affinity purification approach was used to identify FgVam7-interacting proteins to explore its regulatory mechanisms during vesicle trafficking. The orthologs of yeast Vps39, a HOPS tethering complex subunit, and Sso1, a SNARE protein localized to the vacuole or endosome, were identified and selected for further characterization. In yeast two-hybrid and glutathione-S-transferase pull-down assays, FgVam7, FgVps39, and FgSso1 interacted with each other as a complex. The ∆Fgvps39 mutant generated by targeted deletion was significantly reduced in vegetative growth and asexual development. It failed to produce sexual spores and was defective in plant infection and deoxynivalenol production. Further cellular localization and cytological examinations suggested that FgVps39 is involved in vesicle trafficking from early or late endosomes to vacuoles in F. graminearum. Additionally, the ∆Fgvps39 mutant was defective in vacuole morphology and autophagy, and it was delayed in endocytosis. Our results demonstrate that FgVam7 interacts with FgVps39 and FgSso1 to form a unique complex, which is involved in vesicle trafficking and modulating the proper development of infection-related morphogenesis in F. graminearum.
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Credit WCT. Original 4"x5" black and white negative is housed ...
Credit WCT. Original 4"x5" black and white negative is housed in the JPL Archives, Pasadena, California. This view shows Building E-39 under construction. E-39 is an example of the typical reinforced concrete block construction of the E-30s and E-40s structures (JPL negative no. 381-2586, 13 December 1962) - Jet Propulsion Laboratory Edwards Facility, Propellant Curing Building, Edwards Air Force Base, Boron, Kern County, CA
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Code of Federal Regulations, 2014 CFR
2014-07-01
... selection, land acquisition, design and planning, earth moving, landscaping, construction, and provision of... cemetery. Improvement means the enhancement of a cemetery through landscaping, construction, or renovation of cemetery infrastructure, such as building expansion and upgrades to roads and irrigation systems...
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Code of Federal Regulations, 2013 CFR
2013-07-01
... selection, land acquisition, design and planning, earth moving, landscaping, construction, and provision of... cemetery. Improvement means the enhancement of a cemetery through landscaping, construction, or renovation of cemetery infrastructure, such as building expansion and upgrades to roads and irrigation systems...
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Code of Federal Regulations, 2012 CFR
2012-07-01
... selection, land acquisition, design and planning, earth moving, landscaping, construction, and provision of... cemetery. Improvement means the enhancement of a cemetery through landscaping, construction, or renovation of cemetery infrastructure, such as building expansion and upgrades to roads and irrigation systems...
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Development of a Laser Probe for Argon Isotope Studies.
NASA Astrophysics Data System (ADS)
McConville, Paul
Available from UMI in association with The British Library. The first objective of this study was to develop a laser outgassing facility for argon isotope studies. Apart from the laser and construction of the laser sample port, existing vacuum and mass spectrometer systems were used. Laser performance and optimum operating conditions were investigated. The second objective was test and evaluate the laser extraction technique by studies of simple geological samples. Previous laser ^{40} Ar-^{39}Ar dating studies by other workers had not systematically established the basis or characteristics of the method. Results from laser and complementary stepped heating studies of the ^{40}Ar-^ {39}Ar dating standard hornblende, hb3gr; a phlogopite sample from the Palabora (Phalaborwa) Complex; and biotites in a thin section of the Hamlet Bjerg granite from East Greenland, verified that: (1) Laser extraction reproduced within experimental error the stepped heating ^{40}Ar-^ {39}Ar and K-Ar ages of simple samples. (2) The precision of the technique i.e. the amount of sample required to give reliable ages, was limited in the present experiments largely by the level of the blanks and backgrounds to 10-100 ug samples. (3) Sample outgassing appeared to be limited to the order of 10 um outside the physical size of the laser pit, consistent with other estimates of the spatial definition in the literature. This could be understood by thermal diffusion and the length of the laser pulse. (4) The efficiency of the laser pulse in melting and outgassing mineral samples was shown to be dependent on silicate latent heats and mineral absorption at the laser wavelength. In addition, the ^{40} Ar-^{39}Ar age of the geologically significant Palabora Complex was determined as (2053 +/- 5) Ma. Excess argon led to a discrepancy between the laser and stepped heating ages of biotite and muscovite, (405 +/- 5) Ma, and laser ages of feldspars (510 +/- 20) Ma in the Hamlet Bjerg granite. This illustrated one advantage of in situ laser age determinations on mineral grains in thin section. (Abstract shortened by UMI.).
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2007-12-01
Ecology and Environment, Inc.FILE: \\\\Talbdl1\\gis\\DoverEA\\MAPS\\MXD\\FIG-1_DoverAFB_RegionalLocationMap.mxd DATE: August 03...7 "N 39° 7 "N © 2007 Ecology and Environment, Inc.FILE: \\\\Talbdl1\\GIS\\DoverEA\\MAPS\\MXD\\FIG-2_DoverAFB_ExistingProposed_SitePlans.mxd...34W 75°29"W 39° 8" N 39° 8" N 39° 7" N 39° 7" N 39° 6" N 39° 6" N © 2007 Ecology and Environment,
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Water Flow Test at Launch Complex 39B
2017-12-20
Water flowed during a test at Launch Complex 39B at NASA’s Kennedy Space Center in Florida. About 450,000 gallons of water flowed at high speed from a holding tank through new and modified piping and valves, the flame trench, flame deflector nozzles and mobile launcher interface risers during a wet flow test at Launch Complex 39B. At peak flow, the water reached about 100 feet in the air above the pad surface. The test was a milestone to confirm and baseline the performance of the Ignition Overpressure/Sound Suppression system. During launch of NASA's Space Launch System rocket and Orion spacecraft, the high-speed water flow will help protect the vehicle from the extreme acoustic and temperature environment during ignition and liftoff.
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Apollo 14 crew arrive at White Room atop Pad A, Launch Complex 39
NASA Technical Reports Server (NTRS)
1971-01-01
The three Apollo 14 astronauts arrive at the White Room atop Pad A, Launch Complex 39, during the Apollo 14 prelaunch countdown. Note identifying red bands on the sleeve and leg of Shepard. Standing in the center background is Astronaut Thomas P. Stafford, Chief of the Manned Spacecraft Center Astronaut Office.
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model that was on display at the NASA Kennedy Space Center Visitor Complex in Florida negotiates the turn from Kennedy Parkway onto Schwartz Road on its way toward NASA Kennedy Space Center's Launch Complex 39 turn basin. It is standard procedure for large payloads and equipment to travel against the normal flow of traffic under the supervision of a move crew when being transported on or off center property. The 525-foot-tall Vehicle Assembly Building peeps over the treetops, at right. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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2011-12-11
CAPE CANAVERAL, Fla. – The high-fidelity space shuttle model that was on display at the NASA Kennedy Space Center Visitor Complex in Florida travels along Schwartz Road on its way toward NASA Kennedy Space Center's Launch Complex 39 turn basin. It is standard procedure for large payloads and equipment to travel against the normal flow of traffic under the supervision of a move crew when being transported on or off center property. The Assembly and Refurbishment Facility, formerly used to process components of space shuttle solid rocket boosters, is in the background at right. The shuttle was part of a display at the visitor complex that also included an external tank and two solid rocket boosters that were used to show visitors the size of actual space shuttle components. The full-scale shuttle model is being transferred from Kennedy to Space Center Houston, NASA Johnson Space Center's visitor center. The model will stay at the turn basin for a few months until it is ready to be transported to Texas via barge. The move also helps clear the way for the Kennedy Space Center Visitor Complex to begin construction of a new facility next year to display space shuttle Atlantis in 2013. For more information about Space Center Houston, visit http://www.spacecenter.org. Photo credit: NASA/Dimitri Gerondidakis
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NASA Astrophysics Data System (ADS)
Zhizhimov, Oleg; Mazov, Nikolay; Skibin, Sergey
Questions concerned with construction and operation of the distributed information systems on the basis of ANSI/NISO Z39.50 Information Retrieval Protocol are discussed in the paper. The paper is based on authors' practice in developing ZooPARK server. Architecture of distributed information systems, questions of reliability of such systems, minimization of search time and administration are examined. Problems with developing of distributed information systems are also described.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Liu, Heli; Juo, Z. Sean; Shim, Ann Hye-Ryong
Repulsive signaling by Semaphorins and Plexins is crucial for the development and homeostasis of the nervous, immune, and cardiovascular systems. Sema7A acts as both an immune and a neural Semaphorin through PlexinC1, and A39R is a Sema7A mimic secreted by smallpox virus. We report the structures of Sema7A and A39R complexed with the Semaphorin-binding module of PlexinC1. Both structures show two PlexinC1 molecules symmetrically bridged by Semaphorin dimers, in which the Semaphorin and PlexinC1 {beta} propellers interact in an edge-on, orthogonal orientation. Both binding interfaces are dominated by the insertion of the Semaphorin's 4c-4d loop into a deep groove inmore » blade 3 of the PlexinC1 propeller. A39R appears to achieve Sema7A mimicry by preserving key Plexin-binding determinants seen in the mammalian Sema7A complex that have evolved to achieve higher affinity binding to the host-derived PlexinC1. The complex structures support a conserved Semaphorin-Plexin recognition mode and suggest that Plexins are activated by dimerization.« less
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NASA Technical Reports Server (NTRS)
Mata, Carlos T.; Hill, Jonathan D.; Mata, Angel G.; Cummins, Kenneth L.
2014-01-01
From May 2011 through July 2013, the lightning instrumentation at Launch Complex 39B (LC39B) at the Kennedy Space Center, Florida, has obtained high-speed video records and field change waveforms (dE/dt and three-axis dH/dt) for 54 negative polarity return strokes whose strike termination locations and times are known with accuracy of the order of 10 m or less and 1 µs, respectively. A total of 18 strokes terminated directly to the LC39B lighting protection system (LPS), which contains three 181 m towers in a triangular configuration, an overhead catenary wire system on insulating masts, and nine down conductors. An additional 9 strokes terminated on the 106 m lightning protection mast of Launch Complex 39A (LC39A), which is located about 2.7 km southeast of LC39B. The remaining 27 return strokes struck either on the ground or attached to low-elevation grounded objects within about 500 m of the LC39B LPS. Leader/return stroke sequences were imaged at 3200 frames/sec by a network of six Phantom V310 high-speed video cameras. Each of the three towers on LC39B had two high-speed cameras installed at the 147 m level with overlapping fields of view of the center of the pad. The locations of the strike points of 54 return strokes have been compared to time-correlated reports of the Cloud-to-Ground Lightning Surveillance System (CGLSS) and the National Lightning Detection Network (NLDN), and the results of this comparison will be presented and discussed.
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Bing, Feng; Zhao, Yu
2016-01-01
To screen the biomarkers having the ability to predict prognosis after chemotherapy for breast cancers. Three microarray data of breast cancer patients undergoing chemotherapy were collected from Gene Expression Omnibus database. After preprocessing, data in GSE41112 were analyzed using significance analysis of microarrays to screen the differentially expressed genes (DEGs). The DEGs were further analyzed by Differentially Coexpressed Genes and Links to construct a function module, the prognosis efficacy of which was verified by the other two datasets (GSE22226 and GSE58644) using Kaplan-Meier plots. The involved genes in function module were subjected to a univariate Cox regression analysis to confirm whether the expression of each prognostic gene was associated with survival. A total of 511 DEGs between breast cancer patients who received chemotherapy or not were obtained, consisting of 421 upregulated and 90 downregulated genes. Using the Differentially Coexpressed Genes and Links package, 1,244 differentially coexpressed genes (DCGs) were identified, among which 36 DCGs were regulated by the transcription factor complex NFY (NFYA, NFYB, NFYC). These 39 genes constructed a gene module to classify the samples in GSE22226 and GSE58644 into three subtypes and these subtypes exhibited significantly different survival rates. Furthermore, several genes of the 39 DCGs were shown to be significantly associated with good (such as CDC20) and poor (such as ARID4A) prognoses following chemotherapy. Our present study provided a serial of biomarkers for predicting the prognosis of chemotherapy or targets for development of alternative treatment (ie, CDC20 and ARID4A) in breast cancer patients.
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Fearnley, I M; Finel, M; Skehel, J M; Walker, J E
1991-01-01
The 39 kDa and 42 kDa subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria are nuclear-coded components of the hydrophobic protein fraction of the enzyme. Their amino acid sequences have been deduced from the sequences of overlapping cDNA clones. These clones were amplified from total bovine heart cDNA by means of the polymerase chain reaction, with the use of complex mixtures of oligonucleotide primers based upon fragments of protein sequence determined at the N-terminals of the proteins and at internal sites. The protein sequences of the 39 kDa and 42 kDa subunits are 345 and 320 amino acid residues long respectively, and their calculated molecular masses are 39,115 Da and 36,693 Da. Both proteins are predominantly hydrophilic, but each contains one or two hydrophobic segments that could possibly be folded into transmembrane alpha-helices. The bovine 39 kDa protein sequence is related to that of a 40 kDa subunit from complex I from Neurospora crassa mitochondria; otherwise, it is not related significantly to any known sequence, including redox proteins and two polypeptides involved in import of proteins into mitochondria, known as the mitochondrial processing peptidase and the processing-enhancing protein. Therefore the functions of the 39 kDa and 42 kDa subunits of complex I are unknown. The mitochondrial gene product, ND4, a hydrophobic component of complex I with an apparent molecular mass of about 39 kDa, has been identified in preparations of the enzyme. This subunit stains faintly with Coomassie Blue dye, and in many gel systems it is not resolved from the nuclearcoded 36 kDa subunit. Images Fig. 1. PMID:1832859
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SUN, LIJUN; HAO, YUEWEN; NIE, XIAOWEI; ZHANG, XUEXIN; YANG, GUANGXIAO; WANG, QUANYING
2012-01-01
The objective of this study was to investigate the effect of the PR39 recombinant adeno-associated virus (AAV) controlled by the hypoxia-responsive element (HRE) on gene therapy of ischemic heart disease. The minimal HRE was artificially synthesized and the AAV vector controlled by HRE was introduced with NT4-TAT-His-PR39 to investigate the expression of AAV-PR39 in hypoxic vascular endothelial cells (VEC) of human umbilical vein (CRL-1730 cell line) and the angiogenesis-promoting effect in pigs with acute myocardial infraction (AMI). The minimal HRE/CMV was designed and artificially synthesized using the PCR method and cloned with the T vector cloning method. The pSS-HRE-CMV-NT4-6His-PR39-PolyA-AAV plasmid was constructed. Using the calcium phosphate precipitation method, HEK-293 cells were co-transfected with three plasmids to produce the recombinant virus. An equal volume of pSS-HRE-CMV-NT4-6His-PR39-PolyAAAV and enterovirus (EV, blank virus) was transfected into CRL-1730 cell lines, respectively. The immunohistochemical method was used to assay the expression of 6xHis in CRL-1730 cell lines and the expression of PR39 under hypoxia. Eighteen AMI miniature pigs were randomized into the experimental group (HRE-AAV-PR39 group), control group 1 (physical saline group) and control group 2 (EV group). The area of ischemia was assessed with conventional MRI and myocardium perfusion MRI. Pigs were sacrificed at preset time-points to obtain samples of ischemic myocardium. Morphological and pathological data were collected. According to data in the literature and databases, the minimal HRE was designed and synthesized with the PCR method. A large number of HREs were connected to modified pSSHGAAV (pSSV9int-/XbaI) vector followed by insertion of the NT4-6His-PR39 gene segment and, thus, the recombinant plasmid pSS-HRE-CMV-NT4-6His-PR39-PolyA-AAV was successfully constructed. The expression of 6xHis in CRL-1730 cells under the regulation of HRE was assayed using the immunohistochemical method and results showed that the expression was positive in the experimental group. Myocardium perfusion MRI displayed that the infracted area significantly decreased under the action of pSS-HRE-CMV-NT4-PR39-PolyA-AAV. The artificial minimal HRE in CRL-1730 cells effectively and rapidly regulates the expression of the downstream gene NT4-TAT-His-PR39 of the CMV promoter. Recombinant pSS-HRE-CMV-NT4-PR39-Poly-AAAV promotes neoangiogenesis in the ischemic area, reduces the area of infarction and improves heart function. PMID:23226731
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Sun, Lijun; Hao, Yuewen; Nie, Xiaowei; Zhang, Xuexin; Yang, Guangxiao; Wang, Quanying
2012-11-01
The objective of this study was to investigate the effect of the PR39 recombinant adeno-associated virus (AAV) controlled by the hypoxia-responsive element (HRE) on gene therapy of ischemic heart disease. The minimal HRE was artificially synthesized and the AAV vector controlled by HRE was introduced with NT4-TAT-His-PR39 to investigate the expression of AAV-PR39 in hypoxic vascular endothelial cells (VEC) of human umbilical vein (CRL-1730 cell line) and the angiogenesis-promoting effect in pigs with acute myocardial infraction (AMI). The minimal HRE/CMV was designed and artificially synthesized using the PCR method and cloned with the T vector cloning method. The pSS-HRE-CMV-NT4-6His-PR39-PolyA-AAV plasmid was constructed. Using the calcium phosphate precipitation method, HEK-293 cells were co-transfected with three plasmids to produce the recombinant virus. An equal volume of pSS-HRE-CMV-NT4-6His-PR39-PolyAAAV and enterovirus (EV, blank virus) was transfected into CRL-1730 cell lines, respectively. The immunohistochemical method was used to assay the expression of 6xHis in CRL-1730 cell lines and the expression of PR39 under hypoxia. Eighteen AMI miniature pigs were randomized into the experimental group (HRE-AAV-PR39 group), control group 1 (physical saline group) and control group 2 (EV group). The area of ischemia was assessed with conventional MRI and myocardium perfusion MRI. Pigs were sacrificed at preset time-points to obtain samples of ischemic myocardium. Morphological and pathological data were collected. According to data in the literature and databases, the minimal HRE was designed and synthesized with the PCR method. A large number of HREs were connected to modified pSSHGAAV (pSSV9int-/XbaI) vector followed by insertion of the NT4-6His-PR39 gene segment and, thus, the recombinant plasmid pSS-HRE-CMV-NT4-6His-PR39-PolyA-AAV was successfully constructed. The expression of 6xHis in CRL-1730 cells under the regulation of HRE was assayed using the immunohistochemical method and results showed that the expression was positive in the experimental group. Myocardium perfusion MRI displayed that the infracted area significantly decreased under the action of pSS-HRE-CMV-NT4-PR39-PolyA-AAV. The artificial minimal HRE in CRL-1730 cells effectively and rapidly regulates the expression of the downstream gene NT4-TAT-His-PR39 of the CMV promoter. Recombinant pSS-HRE-CMV-NT4-PR39-Poly-AAAV promotes neoangiogenesis in the ischemic area, reduces the area of infarction and improves heart function.
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GaAs integrated circuits and heterojunction devices
NASA Astrophysics Data System (ADS)
Fowlis, Colin
1986-06-01
The state of the art of GaAs technology in the U.S. as it applies to digital and analog integrated circuits is examined. In a market projection, it is noted that whereas analog ICs now largely dominate the market, in 1994 they will amount to only 39 percent vs. 57 percent for digital ICs. The military segment of the market will remain the largest (42 percent in 1994 vs. 70 percent today). ICs using depletion-mode-only FETs can be constructed in various forms, the closest to production being BFL or buffered FET logic. Schottky diode FET logic - a lower power approach - can reach higher complexities and strong efforts are being made in this direction. Enhancement type devices appear essential to reach LSI and VLSI complexity, but process control is still very difficult; strong efforts are under way, both in the U.S. and in Japan. Heterojunction devices appear very promising, although structures are fairly complex, and special fabrication techniques, such as molecular beam epitaxy and MOCVD, are necessary. High-electron-mobility-transistor (HEMT) devices show significant performance advantages over MESFETs at low temperatures. Initial results of heterojunction bipolar transistor devices show promise for high speed A/D converter applications.
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2003-11-24
KENNEDY SPACE CENTER, FLA. - Smoke from a successful controlled burn near KSC’s Launch Complex 39 surrounds the Vehicle Assembly Building and spreads across the horizon. The water in the foreground is the Banana River.
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Discourse Analysis and Social Construction.
ERIC Educational Resources Information Center
Bazerman, Charles
1990-01-01
A brief review of social constructivism as a general movement and how it has been applied in particular to scientific knowledge precedes a review of investigations into the role language and linguistic activities have in the social construction of knowledge. A 39-citation unannotated bibliography is included. (CB)
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NASA Astrophysics Data System (ADS)
Sheth, Hetu; Pande, Kanchan; Vijayan, Anjali; Sharma, Kamal Kant; Cucciniello, Ciro
2017-07-01
The Sarnu-Dandali alkaline complex in Rajasthan, northwestern India, is considered to represent early, pre-flood basalt magmatism in the Deccan Traps province, based on a single 40Ar/39Ar age of 68.57 Ma. Rhyolites found in the complex are considered to be 750 Ma Malani basement. Our new 40Ar/39Ar ages of 88.9-86.8 Ma (for syenites, nephelinite, phonolite and rhyolite) and 66.3 ± 0.4 Ma (2σ, melanephelinite) provide clear evidence that whereas the complex has Deccan-age (66 Ma) components, it is dominantly an older (by 20 million years) alkaline complex, with rhyolites included. Basalt is also known to underlie the Early Cretaceous Sarnu Sandstone. Sarnu-Dandali is thus a periodically rejuvenated alkaline igneous centre, active twice in the Late Cretaceous and also earlier. Many such centres with recurrent continental alkaline magmatism (sometimes over hundreds of millions of years) are known worldwide. The 88.9-86.8 Ma 40Ar/39Ar ages for Sarnu-Dandali rocks fully overlap with those for the Indo-Madagascar flood basalt province formed during continental breakup between India (plus Seychelles) and Madagascar. Recent 40Ar/39Ar work on the Mundwara alkaline complex in Rajasthan, 120 km southeast of Sarnu-Dandali, has also shown polychronous emplacement (over ≥ 45 million years), and 84-80 Ma ages obtained from Mundwara also arguably represent post-breakup stages of the Indo-Madagascar flood basalt volcanism. Remnants of the Indo-Madagascar province are known from several localities in southern India but hitherto unknown from northwestern India 2000 km away. Additional equivalents buried under the vast Deccan Traps are highly likely.
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39. CALCINER CELL PLANS. TOGETHER WITH HAER ID33C37 ILLUSTRATES COMPLEXITY ...
39. CALCINER CELL PLANS. TOGETHER WITH HAER ID-33-C-37 ILLUSTRATES COMPLEXITY OF PIPING. INEEL DRAWING NUMBER 200-0633-00-287-106445. FLUOR NUMBER 5775-CPP-633-P-50 - Idaho National Engineering Laboratory, Old Waste Calcining Facility, Scoville, Butte County, ID
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2010-11-24
CAPE CANAVERAL, Fla. -- The finishing touches of the Propellants North Administrative and Maintenance Facility begin to take place at NASA's Kennedy Space Center in Florida. Inside the green facility is window glazing and framing from the iconic firing rooms of Kennedy's Launch Control Center (LCC). The windows are set at the same orientation and angle as they were in the LCC, looking out toward Launch Complex 39. The facility also features sustainable flooring made of polished concrete and laminated bamboo, as well as a high-efficiency roof and walls. This is the facility's two-story administrative building, which will house managers, mechanics and technicians who fuel spacecraft at Kennedy. Next door is a single-story shop that will be used to store cryogenic fuel transfer equipment. The facility is striving to qualify for the U.S. Green Building Council’s Leadership in Energy and Environmental Design (LEED) Platinum certification, which is the highest of LEED ratings. The facility, set to be complete in December 2010, was designed for NASA by Jones Edmunds and Associates. H. W. Davis Construction is the construction contractor. Photo credit: NASA/Frankie Martin
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2011-10-04
CAPE CANAVERAL, Fla. -- NASA managers at NASA's Kennedy Space Center in Florida show off the Florida Project of the Year trophies that the crawlerway system evaluation team received from the American Society of Civil Engineers (ASCE). From left are Michael Benik, director of Center Operations; Pepper Phillips, manager of the 21st Century Ground Systems Program Office; and Russell Romanella, associate director for Engineering and Technical Operations. The Cape Canaveral branch of the ASCE nominated the team for its project, the Crawlerway Evaluation to Support a Heavy-Lift Program. The crawlerway is a 130-foot-wide, specialty-built roadway between Kennedy's Vehicle Assembly Building (VAB), where rockets and spacecraft are prepared for flight, and Launch Pad 39A and 39B. The team's more than two-year evaluation confirmed the crawlerway system would be able to support the weight of moving the agency's future heavy-lift rockets and potential commercial vehicles from the VAB to the launch pads. The award honors the team's outstanding engineering efforts in research, design, construction and management, recognizing the complexity of multi-agency coordination and cost-effective engineering advances. For more information on the American Society of Civil Engineers, visit: http://www.asce.org. Photo credit: NASA/Kim Shiflett
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Young Children's Block Construction Activities: Findings from 3 Years of Observation.
ERIC Educational Resources Information Center
Hanline, Mary Frances; Milton, Sande; Phelps, Pamela
2001-01-01
A 3-year study explored the development of the complexity of block constructions of 65 preschool children. Results indicated that the complexity of block constructions increased with age, the time the child was involved with block construction activities had a positive effect on complexity, and gender did not influence block construction…
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An Estimate of the Vertical Variability of Temperature at KSC Launch Complex 39-B
NASA Technical Reports Server (NTRS)
Brenton, James
2017-01-01
The purpose of this analysis is to determine the vertical variability of the air temperature below 500 feet at Launch Complex (LC) 39-B at Kennedy Space Center (KSC). This analysis utilizes data from the LC39-B Lightning Protection System (LPS) Towers and the 500 foot Tower 313. The results of this analysis will be used to help evaluate the ambient air temperature Launch Commit Criteria (LCC) for the Exploration Mission 1 launch.
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NASA Astrophysics Data System (ADS)
Vijayan, Anjali; Pande, Kanchan; Sheth, Hetu; Kant Sharma, Kamal
2017-04-01
The Sarnu-Dandali alkaline complex in Rajasthan, northwestern India, is considered to represent early, pre-tholeiite magmatism in the Deccan Traps continental flood basalt (CFB) province, based on a single 40Ar/39Ar age of 68.57 Ma. Rhyolites found in the complex are considered to be 750 Ma Malani basement. Our new 40Ar/39Ar ages of 88.9-86.8 Ma (for syenites, nephelinite, phonolite and rhyolite) and 66.3 ± 0.4 Ma (2σ, melanephelinite) provide clear evidence that whereas the Sarnu-Dandali complex has Deccan-age components, it is dominantly an older (by ˜20 million years) alkaline complex, with rhyolites included. Sarnu-Dandali is thus an alkaline igneous center active at least twice in the Late Cretaceous, and also much before as suggested by a basalt flow underlying the Early Cretaceous Sarnu Sandstone. The 89-86 Ma 40Ar/39Ar ages fully overlap with those for the Indo-Madagascar CFB province formed during continental break-up between India (plus Seychelles) and Madagascar. Recent 40Ar/39Ar work has shown polychronous emplacement (over ≥ 45 million years) of the Mundwara alkaline complex in Rajasthan, 100 km from Sarnu-Dandali, and 84-80 Ma ages obtained from Mundwara also arguably represent late stages of the Indo-Madagascar CFB volcanism. Remnants of the Indo-Madagascar CFB province are known from several localities in southern India but hitherto unknown from northwestern India 2000 km away. Additional equivalents buried under the vast Deccan Traps are highly likely. We relate the Sarnu-Dandali and Mundwara complexes to decompression melting of ancient, subduction-fluxed, enriched mantle lithosphere due to periodic lithospheric extension during much of the Cretaceous, and hundreds of kilometers inland from the India-Madagascar and India-Seychelles rifted margins.
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Nighttime view of Apollo 9 space vehicle at Pad A, Launch Complex 39
1969-02-23
S69-25879 (23 Feb. 1969) --- Nighttime view of the 363-feet-high Apollo 9 space vehicle at Pad A, Launch Complex 39, Kennedy Space Center, during preparations for the scheduled 10-day Earth-orbital space mission. The crew of the Apollo 9 (Spacecraft 104/Lunar Module 3/Saturn 504) space flight will be astronauts James A. McDivitt, David R. Scott, and Russell L. Schweickart.
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Babot, Marion; Labarbuta, Paola; Birch, Amanda; Kee, Sara; Fuszard, Matthew; Botting, Catherine H.; Wittig, Ilka; Heide, Heinrich; Galkin, Alexander
2014-01-01
An intriguing feature of mitochondrial complex I from several species is the so-called A/D transition, whereby the idle enzyme spontaneously converts from the active (A) form to the de-active (D) form. The A/D transition plays an important role in tissue response to the lack of oxygen and hypoxic deactivation of the enzyme is one of the key regulatory events that occur in mitochondria during ischaemia. We demonstrate for the first time that the A/D conformational change of complex I does not affect the macromolecular organisation of supercomplexes in vitro as revealed by two types of native electrophoresis. Cysteine 39 of the mitochondrially-encoded ND3 subunit is known to become exposed upon de-activation. Here we show that even if complex I is a constituent of the I + III2 + IV (S1) supercomplex, cysteine 39 is accessible for chemical modification in only the D-form. Using lysine-specific fluorescent labelling and a DIGE-like approach we further identified two new subunits involved in structural rearrangements during the A/D transition: ND1 (MT-ND1) and 39 kDa (NDUFA9). These results clearly show that structural rearrangements during de-activation of complex I include several subunits located at the junction between hydrophilic and hydrophobic domains, in the region of the quinone binding site. De-activation of mitochondrial complex I results in concerted structural rearrangement of membrane subunits which leads to the disruption of the sealed quinone chamber required for catalytic turnover. PMID:24560811
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Polarization of seven MBM clouds at high Galactic latitude
NASA Astrophysics Data System (ADS)
Neha, S.; Maheswar, G.; Soam, A.; Lee, C. W.
2018-06-01
We made R-band polarization measurements of 234 stars towards the direction of the MBM 33-39 cloud complex. The distance of the MBM 33-39 complex was determined as 120 ± 10 pc using polarization results and near-infrared photometry from the 2MASS survey. The magnetic field geometry of the individual clouds inferred from our polarimetric results reveals that the field lines are in general consistent with the global magnetic field geometry of the region obtained from previous studies. This implies that the clouds in the complex are permeated by the interstellar magnetic field. Multi-wavelength polarization measurements of a few stars projected on to the complex suggest that the size of the dust grains in these clouds is similar to those found in the normal interstellar medium of the Milky Way. We studied a possible formation scenario of the MBM 33-39 complex by combining the polarization results from our study with those from the literature and by identifying the distribution of ionized, atomic and molecular (dust) components of material in the region.
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NASA Technical Reports Server (NTRS)
Wilson, Deborah M.
2016-01-01
This Operations, Maintenance, and Monitoring Report (OMMR) presents the findings, observations, and results from Year 1 operation of the air sparging (AS) groundwater interim measure (IM) for High-Concentration Plumes (HCPs) and Low-Concentration Plumes (LCPs) within the perimeter fence line at Launch Complex 39A (LC39A) located at Kennedy Space Center (KSC), Florida. The objective of the LC39A groundwater IM is to actively decrease concentrations of trichloroethene (TCE), cis-1,2-dichloroethene (cDCE), and vinyl chloride (VC) in groundwater in the HCP and LCP within the pad perimeter fence line via AS to levels less than Florida Department of Environmental Protection (FDEP) Groundwater Cleanup Target Levels (GCTLs). The objective was developed because LC39A is currently being leased to Space Exploration Technologies (SpaceX), and the original IM for monitored natural attenuation (MNA) over an extended period of time was not suitable for future planned site use.
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2013-11-19
CAPE CANAVERAL, Fla. -- At Launch Pad 39B at NASA’s Kennedy Space Center in Florida, all of the old crawler track panels have been removed from the surface and construction workers are repairing the concrete surface and catacomb roof below. At far left is the recently-constructed pad elevator. Launch Pad 39B is being refurbished to support NASA’s Space Launch System and other launch vehicles. The Ground Systems Development and Operations, or GSDO, Program office at Kennedy is leading the center’s transformation to safely handle a variety of rockets and spacecraft. For more information about GSDO, visit: http://go.nasa.gov/groundsystems. Photo credit: NASA/Kim Shiflett
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An Enhanced Z39.50 Gateway to the WorldWideWeb.
ERIC Educational Resources Information Center
Cunningham, David; Sloan, Stephen
1994-01-01
Describes how a university library uses the WorldWideWeb (WWW) to enable users to access resources mounted on a local Z39.50 server and to order prints from articles stored on a CD-ROM jukebox. The software used in the construction of the system, necessary modifications to the software, and software ordering information are covered. (KRN)
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Bing, Feng; Zhao, Yu
2016-01-01
Objective To screen the biomarkers having the ability to predict prognosis after chemotherapy for breast cancers. Methods Three microarray data of breast cancer patients undergoing chemotherapy were collected from Gene Expression Omnibus database. After preprocessing, data in GSE41112 were analyzed using significance analysis of microarrays to screen the differentially expressed genes (DEGs). The DEGs were further analyzed by Differentially Coexpressed Genes and Links to construct a function module, the prognosis efficacy of which was verified by the other two datasets (GSE22226 and GSE58644) using Kaplan–Meier plots. The involved genes in function module were subjected to a univariate Cox regression analysis to confirm whether the expression of each prognostic gene was associated with survival. Results A total of 511 DEGs between breast cancer patients who received chemotherapy or not were obtained, consisting of 421 upregulated and 90 downregulated genes. Using the Differentially Coexpressed Genes and Links package, 1,244 differentially coexpressed genes (DCGs) were identified, among which 36 DCGs were regulated by the transcription factor complex NFY (NFYA, NFYB, NFYC). These 39 genes constructed a gene module to classify the samples in GSE22226 and GSE58644 into three subtypes and these subtypes exhibited significantly different survival rates. Furthermore, several genes of the 39 DCGs were shown to be significantly associated with good (such as CDC20) and poor (such as ARID4A) prognoses following chemotherapy. Conclusion Our present study provided a serial of biomarkers for predicting the prognosis of chemotherapy or targets for development of alternative treatment (ie, CDC20 and ARID4A) in breast cancer patients. PMID:27217777
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NASA Technical Reports Server (NTRS)
Mata, Carlos T.; Mata, Angel G.
2012-01-01
A new Lightning Protection System (LPS) was designed and built at Launch Complex 39B (LC39B), at the Kennedy Space Center (KSC), Florida, which consists of a catenary wire system (at a height of about 181 meters above ground level) supported by three insulators installed atop three towers in a triangular configuration. Nine downconductors (each about 250 meters long) are connected to the catenary wire system. Each downconductor is connected to a 7.62-meter-radius circular counterpoise conductor with six equally spaced, 6-meter-long vertical grounding rods. Grounding requirements at LC39B call for all underground and aboveground metallic piping, enclosures, raceways, and cable trays, within 7.62 meters of the counterpoise, to be bonded to the counterpoise, which results in a complex interconnected grounding system, given the many metallic piping, raceways, and cable trays that run in multiple directions around LC39B. The complexity of this grounding system makes the fall-of-potential method, which uses multiple metallic rods or stakes, unsuitable for measuring the grounding impedances of the downconductors. To calculate the grounding impedance of the downconductors, an Earth Ground Clamp (EGC) (a stakeless device for measuring grounding impedance) and an Alternative Transient Program (ATP) model of the LPS are used. The EGC is used to measure the loop impedance plus the grounding impedance of each downconductor, and the ATP model is used to calculate the loop impedance of each downconductor circuit. The grounding resistance of the downconductors is then calculated by subtracting the ATP calculated loop impedances from the EGC measurements.
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Artesian Well Abandonment at Launch Complex 39A
NASA Technical Reports Server (NTRS)
Morgan, Lindsay; Johansen, Deda
2015-01-01
The artesian well tasked for abandonment was located on the LOX side (northwest area) of the launch complex. The exact date of well installation is unknown. The well was no longer in use at the time of the abandonment request, but was previously utilized under St. Johns River Water Management District (SJRWMD) consumptive use permit (No. 50054) for the Floridian Aquifer. The exact construction details of the LOX artesian well were also unknown; however, a similar-type artesian well was previously located on the LH2 side of the site, which was abandoned in 2012. Based on discussions with the NASA RPM and review of the LH2 artesian well abandonment completion report, the LH2 artesian well was reported to be an 8-inch diameter, 330-foot deep well. The NASA RPM communicated that the LOX artesian well was likely to be an 8-inch diameter, 380-foot deep well. This information was used for scoping, and was subsequently confirmed to be substantially accurate. No additional information could be found for the LOX artesian well using the NASA Remediation Information System (RIS).
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Membrane fractions active in poliovirus RNA replication contain VPg precursor polypeptides
DOE Office of Scientific and Technical Information (OSTI.GOV)
Takegami, T.; Semler, B.L.; Anderson, C.W.
1983-01-01
The poliovirus specific polypeptide P3-9 is of special interest for studies of viral RNA replication because it contains a hydrophobic region and, separated by only seven amino acids from that region, the amino acid sequence of the genome-linked protein VPg. Membraneous complexes of poliovirus-infected HeLa cells that contain poliovirus RNA replicating proteins have been analyzed for the presence of P3-9 by immunoprecipitation. Incubation of a membrane fraction rich in P3-9 with proteinase leaves the C-terminal 69 amino acids of P3-9 intact, an observation suggesting that this portion is protected by its association with the cellular membrane. These studies have alsomore » revealed two hitherto undescribed viral polypeptides consisting of amino acid sequences of the P2 andf P3 regions of the polyprotein. Sequence analysis by stepwise Edman degradation show that these proteins are 3b/9 (M/sub r/77,000) and X/9 (M/sub r/50,000). 3b/9 and X/9 are membrane bound and are turned over rapidly and may be direct precursors to proteins P2-X and P3-9 of the RNA replication complex. P2-X, a polypeptide void of hydrophobic amino acid sequences but also found associated with membranes, is rapidly degraded when the membraneous complex is treated with trypsin. It is speculated that P2-X is associated with membranes by its affinity to the N-terminus of P3-9.« less
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2014-05-20
CAPE CANAVERAL, Fla. -- A crawler-transporter rolls toward Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move Mobile Launcher Platform-2, or MLP-2, from the pad to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett
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2014-05-20
CAPE CANAVERAL, Fla. -- A crawler-transporter carries Mobile Launcher Platform-2, or MLP-2, away from Launch Pad 39A at NASA's Kennedy Space Center in Florida. The MLP is being moved to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett
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2009-01-02
CAPE CANAVERAL, Fla. – On Launch Pad 39B at NASA's Kennedy Space Center in Florida, a crane (at left) completes construction of one of the towers in the new lightning protection system for the Constellation Program and Ares/Orion launches. At right, another tower is being constructed. Each of the three new lightning towers will be 500 feet tall with an additional 100-foot fiberglass mast atop supporting a wire catenary system. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009. Photo credit: NASA/Troy Cryder
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Construction of a Virginia short-span bridge with the Strongwell 36-inch double-web I-beam.
DOT National Transportation Integrated Search
2005-01-01
The Route 601 Bridge in Sugar Grove, VA, spans 39 ft over Dickey Creek. The bridge is the first to use the Strongwell 36-in-deep fiber-reinforced polymer (FRP) double-web beam (DWB) in a vehicular bridge superstructure. Construction of the new bridge...
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ERIC Educational Resources Information Center
Ercikan, Kadriye; Oliveri, María Elena
2016-01-01
Assessing complex constructs such as those discussed under the umbrella of 21st century constructs highlights the need for a principled assessment design and validation approach. In our discussion, we made a case for three considerations: (a) taking construct complexity into account across various stages of assessment development such as the…
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Genomic anatomy of the Tyrp1 (brown) deletion complex
Smyth, Ian M.; Wilming, Laurens; Lee, Angela W.; Taylor, Martin S.; Gautier, Phillipe; Barlow, Karen; Wallis, Justine; Martin, Sancha; Glithero, Rebecca; Phillimore, Ben; Pelan, Sarah; Andrew, Rob; Holt, Karen; Taylor, Ruth; McLaren, Stuart; Burton, John; Bailey, Jonathon; Sims, Sarah; Squares, Jan; Plumb, Bob; Joy, Ann; Gibson, Richard; Gilbert, James; Hart, Elizabeth; Laird, Gavin; Loveland, Jane; Mudge, Jonathan; Steward, Charlie; Swarbreck, David; Harrow, Jennifer; North, Philip; Leaves, Nicholas; Greystrong, John; Coppola, Maria; Manjunath, Shilpa; Campbell, Mark; Smith, Mark; Strachan, Gregory; Tofts, Calli; Boal, Esther; Cobley, Victoria; Hunter, Giselle; Kimberley, Christopher; Thomas, Daniel; Cave-Berry, Lee; Weston, Paul; Botcherby, Marc R. M.; White, Sharon; Edgar, Ruth; Cross, Sally H.; Irvani, Marjan; Hummerich, Holger; Simpson, Eleanor H.; Johnson, Dabney; Hunsicker, Patricia R.; Little, Peter F. R.; Hubbard, Tim; Campbell, R. Duncan; Rogers, Jane; Jackson, Ian J.
2006-01-01
Chromosome deletions in the mouse have proven invaluable in the dissection of gene function. The brown deletion complex comprises >28 independent genome rearrangements, which have been used to identify several functional loci on chromosome 4 required for normal embryonic and postnatal development. We have constructed a 172-bacterial artificial chromosome contig that spans this 22-megabase (Mb) interval and have produced a contiguous, finished, and manually annotated sequence from these clones. The deletion complex is strikingly gene-poor, containing only 52 protein-coding genes (of which only 39 are supported by human homologues) and has several further notable genomic features, including several segments of >1 Mb, apparently devoid of a coding sequence. We have used sequence polymorphisms to finely map the deletion breakpoints and identify strong candidate genes for the known phenotypes that map to this region, including three lethal loci (l4Rn1, l4Rn2, and l4Rn3) and the fitness mutant brown-associated fitness (baf). We have also characterized misexpression of the basonuclin homologue, Bnc2, associated with the inversion-mediated coat color mutant white-based brown (Bw). This study provides a molecular insight into the basis of several characterized mouse mutants, which will allow further dissection of this region by targeted or chemical mutagenesis. PMID:16505357
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STS-26 Discovery, Orbiter Vehicle (OV) 103, at KSC LC pad 39B
1988-07-04
S88-42101 (15 July 1988) --- STS-26 Discovery, Orbiter Vehicle (OV) 103, awaits further processing at Kennedy Space Center (KSC) launch complex (LC) pad 39B. OV-103 arrived at LC pad 39B after a six-hour journey from the vehicle assembly building (VAB). The rotating service structure is retracted.
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NASA Astrophysics Data System (ADS)
Krechowicz, Maria
2017-10-01
Nowadays, one of the characteristic features of construction industry is an increased complexity of a growing number of projects. Almost each construction project is unique, has its project-specific purpose, its own project structural complexity, owner’s expectations, ground conditions unique to a certain location, and its own dynamics. Failure costs and costs resulting from unforeseen problems in complex construction projects are very high. Project complexity drivers pose many vulnerabilities to a successful completion of a number of projects. This paper discusses the process of effective risk management in complex construction projects in which renewable energy sources were used, on the example of the realization phase of the ENERGIS teaching-laboratory building, from the point of view of DORBUD S.A., its general contractor. This paper suggests a new approach to risk management for complex construction projects in which renewable energy sources were applied. The risk management process was divided into six stages: gathering information, identification of the top, critical project risks resulting from the project complexity, construction of the fault tree for each top, critical risks, logical analysis of the fault tree, quantitative risk assessment applying fuzzy logic and development of risk response strategy. A new methodology for the qualitative and quantitative risk assessment for top, critical risks in complex construction projects was developed. Risk assessment was carried out applying Fuzzy Fault Tree analysis on the example of one top critical risk. Application of the Fuzzy sets theory to the proposed model allowed to decrease uncertainty and eliminate problems with gaining the crisp values of the basic events probability, common during expert risk assessment with the objective to give the exact risk score of each unwanted event probability.
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Yang, Jihong; Li, Zheng; Fan, Xiaohui; Cheng, Yiyu
2014-09-22
The high incidence of complex diseases has become a worldwide threat to human health. Multiple targets and pathways are perturbed during the pathological process of complex diseases. Systematic investigation of complex relationship between drugs and diseases is necessary for new association discovery and drug repurposing. For this purpose, three causal networks were constructed herein for cardiovascular diseases, diabetes mellitus, and neoplasms, respectively. A causal inference-probabilistic matrix factorization (CI-PMF) approach was proposed to predict and classify drug-disease associations, and further used for drug-repositioning predictions. First, multilevel systematic relations between drugs and diseases were integrated from heterogeneous databases to construct causal networks connecting drug-target-pathway-gene-disease. Then, the association scores between drugs and diseases were assessed by evaluating a drug's effects on multiple targets and pathways. Furthermore, PMF models were learned based on known interactions, and associations were then classified into three types by trained models. Finally, therapeutic associations were predicted based upon the ranking of association scores and predicted association types. In terms of drug-disease association prediction, modified causal inference included in CI-PMF outperformed existing causal inference with a higher AUC (area under receiver operating characteristic curve) score and greater precision. Moreover, CI-PMF performed better than single modified causal inference in predicting therapeutic drug-disease associations. In the top 30% of predicted associations, 58.6% (136/232), 50.8% (31/61), and 39.8% (140/352) hit known therapeutic associations, while precisions obtained by the latter were only 10.2% (231/2264), 8.8% (36/411), and 9.7% (189/1948). Clinical verifications were further conducted for the top 100 newly predicted therapeutic associations. As a result, 21, 12, and 32 associations have been studied and many treatment effects of drugs on diseases were investigated for cardiovascular diseases, diabetes mellitus, and neoplasms, respectively. Related chains in causal networks were extracted for these 65 clinical-verified associations, and we further illustrated the therapeutic role of etodolac in breast cancer by inferred chains. Overall, CI-PMF is a useful approach for associating drugs with complex diseases and provides potential values for drug repositioning.
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39. HISTORIC VIEW LOOKING WEST AT THE TEST STAND WITH ...
39. HISTORIC VIEW LOOKING WEST AT THE TEST STAND WITH THE COLD CALIBRATION TOWER CONSTRUCTED TO THE LEFT OF THE ROCKET AND AN ACCESS PLATFORM BUILT TO REACH THE TOP OF THE ROCKET MORE EASILY. - Marshall Space Flight Center, Redstone Rocket (Missile) Test Stand, Dodd Road, Huntsville, Madison County, AL
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Gonzalez-Andrade, Martin; Rivera-Chavez, Jose; Sosa-Peinado, Alejandro; Figueroa, Mario; Rodriguez-Sotres, Rogelio; Mata, Rachel
2011-06-09
A novel, sensible, and specific fluorescent biosensor of human calmodulin (hCaM), namely hCaM L39C-mBBr/V91C-mBBr, was constructed. The biosensor was useful for detecting ligands with opposing fluorescent signals, calcium ions (Ca(2+)) and CaM inhibitors in solution. Thus, the device was successfully applied to analyze the allosteric effect of Ca(2+) on trifluoroperazine (TFP) binding to CaM (Ca(2+)K(d) = 0.24 μM ± 0.03 with a stoichiometry 4.10 ± 0.15; TFPK(d) ∼ 5.74-0.53 μM depending on the degree of saturation of Ca(2+), with a stoichiometry of 2:1). In addition, it was suitable for discovering additional xanthones (5, 6, and 8) with anti-CaM properties from the fungus Emericella 25379. The affinity of 1-5, 7, and 8 for the complex (Ca(2+))(4)-CaM was excellent because their experimental K(d)s were in the nM range (4-498 nM). Docking analysis predicted that 1-8 bind to CaM at sites I, III, and IV as does TFP.
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2018-05-02
The 2017 class of astronaut candidates are at United Launch Alliance's Space Launch Complex 41 at Cape Canaveral Air Force Station (CCAFS) in Florida for a familiarization tour. They also toured facilities at Kennedy Space Center, including the Neil Armstrong Operations and Checkout Building high bay; the Launch Control Center, Launch Complex 39B, the Vehicle Assembly Building, Boeing's Commercial Crew and Cargo Facility, and SpaceX's Launch Complex 39A. The candidates will spend about two years getting to know the space station systems and learning how to spacewalk, speak Russian, control the International Space Station's robotic arm and fly T-38s, before they're eligible to be assigned to a mission.
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Ar-40/Ar-39 ages and cosmic ray exposure ages of Apollo 14 samples.
NASA Technical Reports Server (NTRS)
Turner, G.; Huneke, J. C.; Podosek, F. A.; Wasserburg, G. J.
1971-01-01
We have used the Ar-40/Ar-39 dating technique on eight samples of Apollo 14 rocks (14053, 14310), breccia fragments (14321), and soil fragments (14001, 14167). The large basalt fragments give reasonable Ar-40/Ar-39 release patterns and yield well defined crystallization ages of 3.89-3.95 aeons. Correlation of the Ar-40/Ar-39 release patterns with Ar-39/Ar-37 patterns showed that the low temperature fractions with high radiogenic argon loss came from K-rich phases. A highly shocked sample and fragments included in the breccia yield complex release patterns with a low temperature peak. The total argon age of these fragments is 3.95 aeons. Cosmic ray exposure ages on these samples are obtained from the ratio of spallogenic Ar-38 to reactor induced Ar-37 and show a distinct grouping of low exposure ages of 26 m.y. correlated with Cone crater. Other samples have exposure ages of more than 260 m.y. and identify material with a more complex integrated cosmic age exposure history.
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38 CFR 39.60 - General requirements for site selection and construction of veterans cemeteries.
Code of Federal Regulations, 2014 CFR
2014-07-01
... Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) AID FOR THE ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF VETERANS CEMETERIES Establishment, Expansion, and Improvement... design and construction criteria and shall apply to all Establishment, Expansion, and Improvement...
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38 CFR 39.60 - General requirements for site selection and construction of veterans cemeteries.
Code of Federal Regulations, 2012 CFR
2012-07-01
... Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) AID FOR THE ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF VETERANS CEMETERIES Establishment, Expansion, and Improvement... design and construction criteria and shall apply to all Establishment, Expansion, and Improvement...
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38 CFR 39.60 - General requirements for site selection and construction of veterans cemeteries.
Code of Federal Regulations, 2013 CFR
2013-07-01
... Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) AID FOR THE ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF VETERANS CEMETERIES Establishment, Expansion, and Improvement... design and construction criteria and shall apply to all Establishment, Expansion, and Improvement...
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38 CFR 39.63 - Architectural design standards.
Code of Federal Regulations, 2014 CFR
2014-07-01
... 5000, Building Construction and Safety Code, and the 2002 edition of the National Electrical Code, NFPA... 5000, Building Construction and Safety Code. Where the adopted codes state conflicting requirements... the standards set forth in this section, all applicable local and State building codes and regulations...
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38 CFR 39.63 - Architectural design standards.
Code of Federal Regulations, 2012 CFR
2012-07-01
... 5000, Building Construction and Safety Code, and the 2002 edition of the National Electrical Code, NFPA... 5000, Building Construction and Safety Code. Where the adopted codes state conflicting requirements... the standards set forth in this section, all applicable local and State building codes and regulations...
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38 CFR 39.63 - Architectural design standards.
Code of Federal Regulations, 2013 CFR
2013-07-01
... 5000, Building Construction and Safety Code, and the 2002 edition of the National Electrical Code, NFPA... 5000, Building Construction and Safety Code. Where the adopted codes state conflicting requirements... the standards set forth in this section, all applicable local and State building codes and regulations...
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2009-01-02
CAPE CANAVERAL, Fla. – On Launch Pad 39B at NASA's Kennedy Space Center in Florida, a crane completes construction of one of the towers in the new lightning protection system for the Constellation Program and Ares/Orion launches. Other towers are being constructed at left and behind the service structures on the pad. Each of the three new lightning towers will be 500 feet tall with an additional 100-foot fiberglass mast atop supporting a wire catenary system. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009. Photo credit: NASA/Troy Cryder
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Chidgey, Jack W.; Linhartová, Markéta; Komenda, Josef; Jackson, Philip J.; Dickman, Mark J.; Canniffe, Daniel P.; Koník, Peter; Pilný, Jan; Hunter, C. Neil; Sobotka, Roman
2014-01-01
Macromolecular membrane assemblies of chlorophyll-protein complexes efficiently harvest and trap light energy for photosynthesis. To investigate the delivery of chlorophylls to the newly synthesized photosystem apoproteins, a terminal enzyme of chlorophyll biosynthesis, chlorophyll synthase (ChlG), was tagged in the cyanobacterium Synechocystis PCC 6803 (Synechocystis) and used as bait in pull-down experiments. We retrieved an enzymatically active complex comprising ChlG and the high-light-inducible protein HliD, which associates with the Ycf39 protein, a putative assembly factor for photosystem II, and with the YidC/Alb3 insertase. 2D electrophoresis and immunoblotting also provided evidence for the presence of SecY and ribosome subunits. The isolated complex contained chlorophyll, chlorophyllide, and carotenoid pigments. Deletion of hliD elevated the level of the ChlG substrate, chlorophyllide, more than 6-fold; HliD is apparently required for assembly of FLAG-ChlG into larger complexes with other proteins such as Ycf39. These data reveal a link between chlorophyll biosynthesis and the Sec/YidC-dependent cotranslational insertion of nascent photosystem polypeptides into membranes. We expect that this close physical linkage coordinates the arrival of pigments and nascent apoproteins to produce photosynthetic pigment-protein complexes with minimal risk of accumulating phototoxic unbound chlorophylls. PMID:24681617
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Trinh, Vu B; Foster, Alex J; Fairclough, Robert H
2014-05-01
We have designed a 39 amino acid peptide mimic of the conformation-dependent main immunogenic region (MIR) of the Torpedo acetylcholine receptor (TAChR) that joins three discontinuous segments of the Torpedo α-subunit, α(1-12), α(65-79), and α(110 - 115) with two GS linkers: This 39MIR-mimic was expressed in E. coli as a fusion protein with an intein-chitin-binding domain (IChBD) to permit affinity collection on chitin beads. Six MIR-directed monoclonal antibodies (mAbs) bind to this complex and five agonist/antagonist site directed mAbs do not. The complex of MIR-directed mAb-132A with 39MIR has a Kd of (2.11±0.11)×10(-10)M, which is smaller than (7.13±1.20)×10(-10)M for the complex of mAb-132A with α(1-161) and about the same as 3.4×10(-10)M for that of mAb-132A with TAChR. Additionally, the 39MIR-IChBD adsorbs all MIR-directed antibodies (Abs) from an experimental autoimmune myasthenia gravis (EAMG) rat serum. Hence, the 39MIR-mimic has the potential to inactivate or remove pathogenic Torpedo MIR-directed Abs from EAMG sera and to direct a magic bullet to the memory B-cells that produce those pathogenic Abs. The hope is to use this as a guide to produce a mimic of the human MIR on the way to an antigen specific therapeutic agent to treat MG. Copyright © 2014 Elsevier Ltd. All rights reserved.
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Manithody, Chandrashekhara; Yang, Likui; Rezaie, Alireza R
2012-03-27
Recent results have indicated that factor Xa (FXa) cleaves protease-activated receptor 2 (PAR-2) to elicit protective intracellular signaling responses in endothelial cells. In this study, we investigated the molecular determinants of the specificity of FXa interaction with PAR-2 by monitoring the cleavage of PAR-2 by FXa in endothelial cells transiently transfected with a PAR-2 cleavage reporter construct in which the extracellular domain of the receptor was fused to cDNA encoding for alkaline phosphatase. Comparison of the cleavage efficiency of PAR-2 by a series of FXa mutants containing mutations in different surface loops indicated that the acidic residues of 39-loop (Glu-36, Glu-37, and Glu-39) and the basic residues of 60-loop (Lys-62 and Arg-63), 148-loop (Arg-143, Arg-150, and Arg-154), and 162-helix (Arg-165 and Lys-169) contribute to the specificity of receptor recognition by FXa on endothelial cells. This was evidenced by significantly reduced activity of mutants toward PAR-2 expressed on transfected cells. The extent of loss in the PAR-2 cleavage activity of FXa mutants correlated with the extent of loss in their PAR-2-dependent intracellular signaling activity. Further characterization of FXa mutants indicated that, with the exception of basic residues of 162-helix, which play a role in the recognition specificity of the prothrombinase complex, none of the surface loop residues under study makes a significant contribution to the activity of FXa in the prothrombinase complex. These results provide new insight into mechanisms through which FXa specifically interacts with its macromolecular substrates in the clotting and signaling pathways.
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Constructing lightning towers for the Constellation Program and
2007-11-09
On Launch Pad 39B at NASA's Kennedy Space Center, the crane crawler puts a piling into place to be pounded into the ground to help construct lightning towers for the Constellation Program and Ares/Orion launches. Pad B will be the site of the first Ares vehicle launch, including Ares I-X which is scheduled for April 2009.
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Constructing lightning towers for the Constellation Program and
2007-11-09
On Launch Pad 39B at NASA's Kennedy Space Center, the crane crawler lifts a piling into place to be pounded into the ground to help construct lightning towers for the Constellation Program and Ares/Orion launches. Pad B will be the site of the first Ares vehicle launch, including Ares I-X which is scheduled for April 2009.
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1989-10-05
Financial Deficits—Causes, Solutions 36 INDUSTRY Airplane Production Reaches 13,000 [XINHUA] 39 Article Reports on Henan’s Industry , Reform...HENAN RIBAO 12 Aug] 39 Jilin Reports 40 Years’ Industrial Development [Changchun Radio] 42 Industrial Belt Taking Shape in Yangtze River Delta...XINHUA] 43 Tangshan Becomes Major Industrial Center [XINHUA] 44 CONSTRUCTION Per Capita Living Space ’Increases’ [XINHUA] 44 Shanghai
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2014-05-20
CAPE CANAVERAL, Fla. -- A crawler-transporter begins its climb toward Mobile Launcher Platform-2, or MLP-2, on the hardstand at Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move the MLP to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett
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2014-05-20
CAPE CANAVERAL, Fla. -- The flame trench comes into view on Launch Pad 39A as a crawler-transporter hauls Mobile Launcher Platform-2, or MLP-2, off the pad at NASA's Kennedy Space Center in Florida. The MLP is being moved to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett
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2014-05-20
CAPE CANAVERAL, Fla. -- A crawler-transporter nears the Mobile Launcher Platform-2, or MLP-2, positioned over the flame trench at Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move the MLP to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett
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2014-05-20
CAPE CANAVERAL, Fla. -- A crawler-transporter begins its climb to the hardstand at Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move Mobile Launcher Platform-2, or MLP-2, from the pad to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett
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2014-05-20
CAPE CANAVERAL, Fla. -- A crawler-transporter creeps toward Mobile Launcher Platform-2, or MLP-2, on the hardstand at Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move the MLP to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett
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2014-05-20
CAPE CANAVERAL, Fla. -- A crawler-transporter rolls under the Mobile Launcher Platform-2, or MLP-2, positioned over the flame trench at Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move the MLP to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett
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2014-05-20
CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, Mobile Launcher Platform-2, or MLP-2, rolling away from Launch Pad 39A atop a crawler-transporter, was positioned over the pad's flame trench only moments before. The MLP is being moved to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett
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2014-05-20
CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, a truck sprays water along the crawlerway to reduce dust ahead of the crawler-transporter moving Mobile Launcher Platform-2, or MLP-2, from Launch Pad 39A to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett
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2014-05-20
CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, a truck sprays water along the crawlerway to reduce dust ahead of the crawler-transporter moving Mobile Launcher Platform-2, or MLP-2, from Launch Pad 39A, in the background, to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett
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The development of an energy-independent personnel neutron dosimeter using CR-39
DOE Office of Scientific and Technical Information (OSTI.GOV)
Doremus, S.W.
The addition of specialized (n,{alpha}) radiators to a standard polyethylene/CR-39 (PE/CR-39) neutron dosimetry system was evaluated for improved response to low energy neutrons. Specialized radiators consisting of poly(vinyl alcohol) complexed with boron (natural and enriched boron-10) and poly(acrylic acid) complexed with lithium (enriched lithium-6) were evaluated. The complexion of boron with poly(vinyl alcohol) was accomplished by incorporation or surface coating. The complexion of lithium with poly(acrylic acid) was exclusively performed by incorporation. The dosimeter was designed such that the specialized radiator was in contact with the CR-39 detector (i.e., the specialized radiator was sandwiched between the CR-39 detector and polyethylenemore » radiator). The neutron response of this dosimetry system was investigated using {sup 252}Cf (moderated and bare) spontaneous fission neutrons. Detectors were chemically etched and then read with a Nikon OPTIPHOT microscope. The mean response (tracks {center dot} field{sup {minus}1}) of detectors treated with specialized (n,{alpha}) radiators were evaluated against PE/CR-39 controls. The results of this investigation demonstrate that PE/CR-39 dosimeters equipped with specialized (n,{alpha}) radiators have a noticeable response to low energy neutrons that in many instances is significantly greater than that of the controls. The addition of specialized radiators to this dosimetry system did not effect (diminish) its response to fast neutrons.« less
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2014-05-20
CAPE CANAVERAL, Fla. -- The crawler-transporter transporting Mobile Launcher Platform-2, or MLP-2, from Launch Pad 39A creeps along the crawlerway toward the Vehicle Assembly Building, or VAB, at NASA's Kennedy Space Center in Florida. The MLP is being moved to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett
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Vibro-Acoustic Analysis of NASA's Space Shuttle Launch Pad 39A Flame Trench Wall
NASA Technical Reports Server (NTRS)
Margasahayam, Ravi N.
2009-01-01
A vital element to NASA's manned space flight launch operations is the Kennedy Space Center Launch Complex 39's launch pads A and B. Originally designed and constructed In the 1960s for the Saturn V rockets used for the Apollo missions, these pads were modified above grade to support Space Shuttle missions. But below grade, each of the pad's original walls (including a 42 feet deep, 58 feet wide, and 450 feet long tunnel designed to deflect flames and exhaust gases, the flame trench) remained unchanged. On May 31, 2008 during the launch of STS-124, over 3500 of the. 22000 interlocking refractory bricks that lined east wall of the flame trench, protecting the pad structure were liberated from pad 39A. The STS-124 launch anomaly spawned an agency-wide initiative to determine the failure root cause, to assess the impact of debris on vehicle and ground support equipment safety, and to prescribe corrective action. The investigation encompassed radar imaging, infrared video review, debris transport mechanism analysis using computational fluid dynamics, destructive testing, and non-destructive evaluation, including vibroacoustic analysis, in order to validate the corrective action. The primary focus of this paper is on the analytic approach, including static, modal, and vibro-acoustic analysis, required to certify the corrective action, and ensure Integrity and operational reliability for future launches. Due to the absence of instrumentation (including pressure transducers, acoustic pressure sensors, and accelerometers) in the flame trench, defining an accurate acoustic signature of the launch environment during shuttle main engine/solid rocket booster Ignition and vehicle ascent posed a significant challenge. Details of the analysis, including the derivation of launch environments, the finite element approach taken, and analysistest/ launch data correlation are discussed. Data obtained from the recent launch of STS-126 from Pad 39A was instrumental in validating the design analysis philosophies outlined in this paper.
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Ergotamine-induced complex rectovaginal fistula. Report of a case.
Pfeifer, J; Reissman, P; Wexner, S D
1995-11-01
This report stresses the importance of local complications caused by ergotamine abuse for the treatment of migraine headaches. We present an unusual case of a complex rectovaginal fistula (RVF) caused by long-term ergotamine suppository abuse. A 39-year-old female was referred after she had undergone a transverse colostomy for temporary fecal diversion. Evaluation, including proctoscopy, gastrograffin enema, vaginogram, and pelvic computerized tomography revealed a RVF 6 cm proximal to the dentate line with distal rectal stricture. Surgical intervention included take down of the transverse colostomy with reanastomosis, proctectomy with excision of the fistula, creation of a colonic "J-pouch" with a coloanal anastomosis, and construction of a temporary loop ileostomy. The patient had an uneventful recovery, and her ileostomy was closed three months later. Pathologic examination of the surgical specimen failed to reveal any specific etiology of the RVF. However, her ten-year use of up to five ergotamine suppositories per day for migraine treatment is associated with a local ischemic effect. Pathophysiology of this rare cause of RVF and the surgical procedure are discussed. If evidence of any side effects of ergotamine suppositories is seen, early discontinuation of the drug should be considered to avoid complications such as RVF and/or strictures.
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STS-27 Atlantis, Orbiter Vehicle (OV) 104, at KSC Launch Complex (LC) pad 39B
NASA Technical Reports Server (NTRS)
1988-01-01
STS-27 Atlantis, Orbiter Vehicle (OV) 104, sits atop the mobile launcher platform at Kennedy Space Center (KSC) Launch Complex (LC) pad 39B. Profile of OV-104 mounted on external tank and flanked by solid rocket boosters (SRBs) is obscured by a flock of seagulls in the foreground. The fixed service structure (FSS) with rotating service structure (RSS) retracted appears in the background. Water resevoir is visible at the base of the launch pad concrete structure.
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2003-07-23
KENNEDY SPACE CENTER, FLA. – This aerial view shows Launch Complex 39 Area. At center is the 525-foot-tall Vehicle Assembly Building. On the horizon at the far left is Launch Pad 39B; to the right is Launch Pad 39A. The crawlerway can be seen stretching from the VAB toward Pad A. Waters of the Banana Creek and Banana River surround the pads. At center right is the Turn Basin.
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2003-07-23
CAPE CANAVERAL, Fla. -- This aerial view shows the Launch Complex 39 Area. At center is the 525-foot-tall Vehicle Assembly Building. On the horizon at the far left is Launch Pad 39B to the right is Launch Pad 39A. The crawlerway can be seen stretching from the VAB toward Pad A. Waters of the Banana Creek and Banana River surround the pads. At center right is the Turn Basin. Photo credit: NASA
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Constructing lightning towers for the Constellation Program and
2007-11-09
On Launch Pad 39B at NASA's Kennedy Space Center, the crane crawler lifts a piling off a truck. The piling will be pounded into the ground to help construct lightning towers for the Constellation Program and Ares/Orion launches. Pad B will be the site of the first Ares vehicle launch, including Ares I-X which is scheduled for April 2009.
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Project Sedan, On-Site Radiological Safety Report
1962-10-23
construction site between U2a & 95 U3a Complete construction area average 100 7/12/62 1530 Outside Bunker 2-300 50 7/12/62 1532 Inside Bunker 2-330 4 39...Analysis of Weather and Surface Radiation Data SC 202F Long Range Blast Propagation REECO 203F On-Site Rad-Safe AEC/ USBM 204F Structural Survey of
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Zhu, Yongxia; Wei, Wei; Ye, Tinghong; Liu, Zhihao; Liu, Li; Luo, Yong; Zhang, Lidan; Gao, Chao; Wang, Ningyu; Yu, Luoting
2016-01-01
Cancer is still a major public health issue worldwide, and new therapeutics with anti-tumor activity are still urgently needed. The anti-tumor activity of TH-39, which shows potent anti-proliferative activity against K562 cells with an IC50 of 0.78 µM, was investigated using immunoblot, co-immunoprecipitation, the MTT assay, and flow cytometry. Mechanistically, TH-39 may disrupt the interaction between Hec1 and Nek2 in K562 cells. Moreover, TH-39 inhibited cell proliferation in a concentration- and time-dependent manner by influencing the morphology of K562 cells and inducing G0/G1 phase arrest. G0/G1 phase arrest was associated with down-regulation of CDK2-cyclin E complex and CDK4/6-cyclin D complex activities. Furthermore, TH-39 also induced cell apoptosis, which was associated with activation of caspase-3, down-regulation of Bcl-2 expression and up-regulation of Bax. TH-39 could also decrease mitochondrial membrane potential (Δψm) and increase reactive oxygen species (ROS) accumulation in K562 cells. The results indicated that TH-39 might induce apoptosis via the ROS-mitochondrial apoptotic pathway. This study highlights the potential therapeutic efficacy of the anti-cancer compound TH-39 in treatment-resistant chronic myeloid leukemia. © 2016 The Author(s) Published by S. Karger AG, Basel.
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Nassriya Water Treatment Plant Nassriya, Iraq. Sustainment Assessment
2008-04-28
Progress During Construction 8 Status of the WTP at Time of Turnover 11 Site Assessment 13 Continuing Problems for the Nassriya WTP 27...Future Plans for the Nassriya WTP 35 Conclusions 37 Recommendations 38 Management Comments 39 Evaluation of Management Comments 39...Appendices A. Scope and Methodology 40 B. FluorAmec’s Organizational Structure for the Nassriya WTP 41 C. FluorAmec’s Nassriya WTP Staffing Plan 42 D
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European Science Notes. Volume 39, Number 8.
1985-08-01
electrophysiological 370 -- , * * ESN 39-8 (1985) slower increment of the speed to the end mus which occurs immediately after the phase . The initial jump is... curve and that removal appears to simple constructions, ease of modula- correspond more closely with the melt tion, and efficient discharge excita- phase ...separate experimental condi- (uncued condition). On some trials the tions. Figure 2 shows the curves for light actually appeared in a location the four
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NASA Astrophysics Data System (ADS)
Pande, Kanchan; Cucciniello, Ciro; Sheth, Hetu; Vijayan, Anjali; Sharma, Kamal Kant; Purohit, Ritesh; Jagadeesan, K. C.; Shinde, Sapna
2017-07-01
The Mundwara alkaline plutonic complex (Rajasthan, north-western India) is considered a part of the Late Cretaceous-Palaeogene Deccan Traps flood basalt province, based on geochronological data (mainly 40Ar/39Ar, on whole rocks, biotite and hornblende). We have studied the petrology and mineral chemistry of some Mundwara mafic rocks containing mica and amphibole. Geothermobarometry indicates emplacement of the complex at middle to upper crustal levels. We have obtained new 40Ar/39Ar ages of 80-84 Ma on biotite separates from mafic rocks and 102-110 Ma on whole-rock nepheline syenites. There is no evidence for excess 40Ar. The combined results show that some of the constituent intrusions of the Mundwara complex are of Deccan age, but others are older and unrelated to the Deccan Traps. The Mundwara alkaline complex is thus polychronous and similar to many alkaline complexes around the world that show recurrent magmatism, sometimes over hundreds of millions of years. The primary biotite and amphibole in Mundwara mafic rocks indicate hydrous parental magmas, derived from hydrated mantle peridotite at relatively low temperatures, thus ruling out a mantle plume. This hydration and metasomatism of the Rajasthan lithospheric mantle may have occurred during Jurassic subduction under Gondwanaland, or Precambrian subduction events. Low-degree decompression melting of this old, enriched lithospheric mantle, due to periodic diffuse lithospheric extension, gradually built the Mundwara complex from the Early Cretaceous to Palaeogene time.
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The (FHCl)- molecular anion - Structural aspects, global surface, and vibrational eigenspectrum
NASA Technical Reports Server (NTRS)
Klepeis, Neil E.; East, Allan L. L.; Csaszar, Attila G.; Allen, Wesley D.; Lee, Timothy J.; Schwenke, David W.
1993-01-01
State of the art ab initio electronic structure methods have been used to investigate the (FHCl)- molecular anion. It is proposed that the geometric structure and binding energies of the complex are r(e)(H-F) = 0.963 +/- 0.003 A, R(e)(H-Cl) = 1.925 +/- 0.015 A, and D0(HF + Cl(-)) = 21.8 +/- 0.4 kcal/mol. A Morokuma decomposition of the ion-molecular bonding give the following electrostatic, polarization, exchange repulsion, dispersion, and charge-transfer plus higher-order mixing components of the vibrationless complexation energy: -27.3, -5.2, +18.3, -4.5, and -5.0 kcal/mol, respectively. A couples cluster single and doubles global surface is constructed from 208 and 228 energy points for linear and bent configurations, respectively, these being fit to rms errors of only 3.9 and 9.3/cm, respectively, below 8000/cm. Converged J = 0 and J = 1 variational eigenstates of the (FHCl)- surface to near the HF + Cl(-) dissociation threshold are determined. The fundamental vibrational frequencies are found to be nu1 = 247/cm, nu2 = 876/cm, and nu3 = 2884/cm. The complete vibrational eigenspectrum is analyzed.
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APOLLO XII - LAUNCH DAY ACTIVITIES - LAUNCH COMPLEX 39A - KSC
1969-11-14
S69-58880 (14 Nov. 1969) --- Astronaut Alan L. Bean, Apollo 12 lunar module pilot, suits up in the Kennedy Space Center's (KSC) Manned Spacecraft Operations Building during the Apollo 12 prelaunch countdown. Minutes later astronauts Bean; Charles Conrad Jr., commander; and Richard F. Gordon Jr., command module pilot, rode a special transport van over to Pad A, Launch Complex 39, where their spacecraft awaited. The Apollo 12 liftoff occurred at 11:22 a.m. (EST), Nov. 14, 1969. Apollo 12 is the United States' second lunar landing mission.
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1987-12-01
embody the distinctive characteristics of a type, period, or method of construction, or that represent the work of a master, or that possess high...e Tl -’J. 39.1 37miA o= -0 38cvq 39 47am 0 0 . Unit 11 17N, 38E Unrt 12 I7N 39E Drsn by A ProjectAv. paint t WACe 0 Vh.wtewre sherd * 3u1t4oR 10-6...tape and transit method but because of the vegetation it was not possible to place the shovel tests at completely systematic intervals. Their location
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2009-01-02
CAPE CANAVERAL, Fla. – On Launch Pad 39B at NASA's Kennedy Space Center in Florida, a crane places the 100-foot fiberglass mast atop the new lightning tower constructed on the pad. The towers are part of the new lightning protection system for the Constellation Program and Ares/Orion launches. At left of the service structures is another tower under construction. Each of the three new lightning towers will be 500 feet tall with the additional 100-foot fiberglass mast atop supporting a wire catenary system. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009. Photo credit: NASA/Kim Shiflett
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NASA Technical Reports Server (NTRS)
Johnson, Jill W.; Towns, Crystal
2015-01-01
This document has been prepared by Geosyntec Consultants, Inc. (Geosyntec) to present and discuss the findings of the 2014 and 2015 Long-Term Monitoring (LTM) activities that were completed at the Launch Complex 39 (LC39) Observation Gantry Area (OGA) located at the John F. Kennedy Space Center (KSC), Florida (Site). The remainder of this report includes: (i) a description of the Site location; (ii) summary of Site background and previous investigations; (iii) description of field activities completed as part of the annual LTM program at the Site; (iv) groundwater flow evaluation; (v) presentation and discussion of field and analytical results; and (vi) conclusions and recommendations. Applicable KSC Remediation Team (KSCRT) Meeting minutes are included in Attachment A. This Annual LTM Letter Report was prepared by Geosyntec Consultants (Geosyntec) for NASA under contract number NNK12CA13B, Delivery Order NNK13CA39T project number PCN ENV2188.
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NASA Technical Reports Server (NTRS)
Mata, Carlos T.; Mata, Angel G.; Rakov, V. A.; Nag, A.; Saul, Jon
2012-01-01
A new comprehensive lightning instrumentation system has been designed for Launch Complex 39B (LC39B) at the Kennedy Space Center, Florida. This new instrumentation system includes six synchronized high-speed video cameras, current sensors installed on the nine downcouductors of the new lightning protection system (LPS) for LC39B; four dH/dt, 3-axis measurement stations; and five dE/dt stations composed of two antennas each. The LPS received 8 direct lightning strikes (a total of 19 strokes) from March 31 through December 31, 2011. The measured peak currents and locations are compared to those reported by the CGLSS 11 and the NLDN. Results of comparison are presented and analyzed in this paper.
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2009-12-11
CAPE CANAVERAL, Fla. - Construction of the Propellants North Administrative and Maintenance Facility begins in Launch Complex 39 at NASA's Kennedy Space Center in Florida. The facility will have a two-story administrative building to house managers, mechanics and technicians who fuel spacecraft at Kennedy adjacent to an 1,800-square-foot single-story shop to store cryogenic fuel transfer equipment. The new facility will feature high-efficiency roofs and walls, “Cool Dry Quiet” air conditioning with energy recovery technology, efficient lighting, and other sustainable features. The facility is striving to qualify for the U.S. Green Building Council’s Leadership in Energy and Environmental Design, or LEED, Platinum certification. If successful, Propellants North will be the first Kennedy facility to achieve this highest of LEED ratings after it is completed in the summer of 2010. The facility was designed for NASA by Jones Edmunds and Associates. Photo credit: NASA/Jim Grossmann
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Vps33b pathogenic mutations preferentially affect VIPAS39/SPE-39-positive endosomes.
Tornieri, Karine; Zlatic, Stephanie A; Mullin, Ariana P; Werner, Erica; Harrison, Robert; L'hernault, Steven W; Faundez, Victor
2013-12-20
Mutations in Vps33 isoforms cause pigment dilution in mice (Vps33a, buff) and Drosophila (car) and the neurogenic arthrogryposis, renal dysfunction and cholestasis syndrome in humans (ARC1, VPS33B). The later disease is also caused by mutations in VIPAS39, (Vps33b interacting protein, apical-basolateral polarity regulator, SPE-39 homolog; ARC2), a protein that interacts with the HOmotypic fusion and Protein Sorting (HOPS) complex, a tether necessary for endosome-lysosome traffic. These syndromes offer insight into fundamental endosome traffic processes unique to metazoans. However, the molecular and cellular mechanisms underlying these mutant phenotypes remain poorly understood. Here we investigate interactions of wild-type and disease-causing mutations in VIPAS39/SPE-39 and Vps33b by yeast two hybrid, immunoprecipitation and quantitative fluorescent microscopy. We find that although few mutations prevent interaction between VIPAS39/SPE-39 and Vps33b, some mutants fragment VIPAS39/SPE-39-positive endosomes, but all mutants alter the subcellular localization of Vps33b to VIPAS39/SPE-39-positive endosomes. Our data suggest that the ARC syndrome may result through impaired VIPAS39/SPE-39 and Vps33b-dependent endosomal maturation or fusion.
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Kuo, Yu-Chi; Chan, Jomei; Wu, Yu-Ping; Bernard, Jeffrey R; Liao, Yi-Hung
2017-01-01
The purpose of this study was to investigate the effects of 4-weeks expiratory muscle strength training (EMST) on the maximum expiratory pressure (PEmax) and quality of life (QoL) in patients with Parkinson disease (PD). Thirteen outpatients diagnosed with PD participated in this study, and were assigned into either a 5DE training group (5DE group; n = 4; 75% PEmax for 5-d/wk), 3DE training group (3DE group; n = 5; 75% PEmax for 3-d/wk) and control group (3DC group; n = 4; 0% PEmax for 3-d/wk) by matching their Hoehn and Yahr scale, genders, and age. The PEmax and Parkinson disease questionnaire-39 item (PDQ-39) were evaluated pre- and post-intervention. The posttest PEmax of the 5DE was significantly higher than that of the 3DC (P < 0.05). Moreover, 5DE and 3DE but not 3DC significantly increased PEmax after training. There were no differences in the overall quality of life in PD patients measured by PDQ-39 among three groups, but the 5DE group significantly improved the mobility constructs of PDQ-39 compared with 3DC (P < 0.05). Both 5 d/wk and 3 d/wk of EMST effectively enhance respiratory muscle strength and improve mobility construct measured by PDQ-39 in patients with PD.
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Kozłowska, Małgorzata; Tarczewska, Aneta; Jakób, Michał; Bystranowska, Dominika; Taube, Michał; Kozak, Maciej; Czarnocki-Cieciura, Mariusz; Dziembowski, Andrzej; Orłowski, Marek; Tkocz, Katarzyna; Ożyhar, Andrzej
2017-01-01
Nucleoplasmins are a nuclear chaperone family defined by the presence of a highly conserved N-terminal core domain. X-ray crystallographic studies of isolated nucleoplasmin core domains revealed a β-propeller structure consisting of a set of five monomers that together form a stable pentamer. Recent studies on isolated N-terminal domains from Drosophila 39-kDa FK506-binding protein (FKBP39) and from other chromatin-associated proteins showed analogous, nucleoplasmin-like (NPL) pentameric structures. Here, we report that the NPL domain of the full-length FKBP39 does not form pentameric complexes. Multi-angle light scattering (MALS) and sedimentation equilibrium ultracentrifugation (SE AUC) analyses of the molecular mass of the full-length protein indicated that FKBP39 forms homotetrameric complexes. Molecular models reconstructed from small-angle X-ray scattering (SAXS) revealed that the NPL domain forms a stable, tetrameric core and that FK506-binding domains are linked to it by intrinsically disordered, flexible chains that form tentacle-like segments. Analyses of full-length FKBP39 and its isolated NPL domain suggested that the distal regions of the polypeptide chain influence and determine the quaternary conformation of the nucleoplasmin-like protein. These results provide new insights regarding the conserved structure of nucleoplasmin core domains and provide a potential explanation for the importance of the tetrameric structural organization of full-length nucleoplasmins. PMID:28074868
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What's Worth Talking about? Meaning-Making in Toddler-Initiated Co-Narratives in Preschool
ERIC Educational Resources Information Center
Odegaard, Elin Eriksen
2006-01-01
To elaborate narratives, toddlers are dependent on adult co-construction. Both children and teachers make meaning and learn together. This article examines what themes toddlers introduce in mealtime conversations in preschool. The object of analysis is 39 toddler-initiated co-narratives constructed by toddlers and teachers in 15 videotaped meals…
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Constructing lightning towers for the Constellation Program and
2007-11-09
On Launch Pad 39B at NASA's Kennedy Space Center, pilings are being pounded into the ground to help construct lightning towers for the Constellation Program and Ares/Orion launches. Pad B will be the site of the first Ares vehicle launch, including Ares I-X which is scheduled for April 2009.
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Constructing lightning towers for the Constellation Program and
2007-11-09
On Launch Pad 39B at NASA's Kennedy Space Center, workers measure the piling being pounded into the ground to help construct lightning towers for the Constellation Program and Ares/Orion launches. Pad B will be the site of the first Ares vehicle launch, including Ares I-X which is scheduled for April 2009.
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ERIC Educational Resources Information Center
Ghadi, Ibrahim; Alwi, Nor Hayati; Bakar, Kamariah Abu; Talib, Othman
2012-01-01
This research aims to evaluate the psychology properties of the construct validity for the Critical Thinking Disposition (CTD) instrument. The CTD instrument consists of 39 Likert-type items measuring seven dispositions, namely analyticity, open-mind, truth-seeking, systematicity, self-confidence inquisitiveness and maturity. The study involves…
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Adhesion Testing of Firebricks from Launch Pad 39A Flame Trench after STS-124
NASA Technical Reports Server (NTRS)
Hintze, Paul E.; Curran, Jerome P.
2009-01-01
Adhesion testing was performed on the firebricks in the flame trench of Launch Complex 39A to determine the strength of the epoxy/firebrick bond to the backing concrete wall. The testing used an Elcometer 110 pneumatic adhesion tensile testing instrument (PATTI).
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38 CFR 39.31 - Preapplication requirements.
Code of Federal Regulations, 2013 CFR
2013-07-01
... documentation, as needed). (4) A design concept describing the major features of the project including the... space, or functional layout; and it will not enter into a construction contract for the project or...
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38 CFR 39.31 - Preapplication requirements.
Code of Federal Regulations, 2012 CFR
2012-07-01
... documentation, as needed). (4) A design concept describing the major features of the project including the... space, or functional layout; and it will not enter into a construction contract for the project or...
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2018-05-01
The 2017 class of astronaut candidates tour Boeing's Commercial Crew and Cargo Facility at NASA's Kennedy Space Center in Florida on May 1. They are at the center for a familiarization tour of facilities, including the Neil Armstrong Operations and Checkout Building high bay; the Launch Control Center, Launch Complex 39B, and the Vehicle Assembly Building. They also toured United Launch Alliance's Space Launch Complex 41 at Cape Canaveral Air Force Station, and SpaceX's Launch Complex 39A at Kennedy. The candidates will spend about two years getting to know the space station systems and learning how to spacewalk, speak Russian, control the International Space Station's robotic arm and fly T-38s, before they're eligible to be assigned to a mission.
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2018-05-01
The 2017 class of astronaut candidates arrive at Boeing's Commercial Crew and Cargo Facility at NASA's Kennedy Space Center in Florida on May 1. They are at the center for a familiarization tour of facilities, including the Neil Armstrong Operations and Checkout Building high bay; the Launch Control Center, Launch Complex 39B, and the Vehicle Assembly Building. They also toured United Launch Alliance's Space Launch Complex 41 at Cape Canaveral Air Force Station, and SpaceX's Launch Complex 39A at Kennedy. The candidates will spend about two years getting to know the space station systems and learning how to spacewalk, speak Russian, control the International Space Station's robotic arm and fly T-38s, before they're eligible to be assigned to a mission.
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View of the Apollo 10 space vehicle at Pad B, ready for launch
NASA Technical Reports Server (NTRS)
1969-01-01
Ground-level view at sunset of the Apollo 10 (Spacecraft 106/Lunar Module 4/Saturn 505) space vehicle at Pad B, Launch Complex 39, Kennedy Space Center. The Apollo 10 stack had just been positioned after being rolled out from the Vehicle Assemble Building (VAB) (34318); View of the Apollo 10 space vehicle (through palm trees and across water) on the way from the VAB to Pad B, Launch Complex 39. The Saturn V and its mobile launch tower are atop a crawler-transporter (34319).
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38 CFR 39.31 - Preapplication requirements.
Code of Federal Regulations, 2011 CFR
2011-07-01
...) A design concept describing the major features of the project including the number and types of... project, use of space, or functional layout; and it will not enter into a construction contract for the...
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2014-05-20
CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, Mobile Launcher Platform-2, or MLP-2, is glimpsed across the water as it departs Launch Pad 39A atop a crawler-transporter. A pad on Cape Canaveral Air Force Station is in view in the background. The MLP is being moved to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett
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15 CFR 930.39 - Content of a consistency determination.
Code of Federal Regulations, 2010 CFR
2010-01-01
... and construction of access road, connecting pipeline, support buildings, and the effects of the associated facilities (e.g., erosion, wetlands, beach access impacts), must all be consistent to the maximum...
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2016-09-01
Military Construction Decisions Report to Congressional Requesters September 2016 GAO-16-853 United States Government Accountability Office...ANALYSIS COMPLEX DOD Partially Used Best Practices for Analyzing Alternatives and Should Do So Fully for Future Military Construction Decisions What...a set of AOA best practices for military construction decisions. Without guidance for using AOA best practices during certain military construction
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39. Perimeter acquisition radar building room #504, techinal maintenance and ...
39. Perimeter acquisition radar building room #504, techinal maintenance and repair center (TMRC) and tactical support equipment (TSE) storage area; storage-travel wave tubes - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Building, Limited Access Area, between Limited Access Patrol Road & Service Road A, Nekoma, Cavalier County, ND
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Code of Federal Regulations, 2010 CFR
2010-07-01
... trails, or boardwalks, including signs, the primary purposes of which are public education... Architectural Barriers Act or postal accessibility standards; (3) Any facility construction project deemed...
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Management of colorectal emergencies: percutaneous abscess drainage.
Brusciano, L; Maffettone, V; Napolitano, V; Izzo, G; Rossetti, G; Izzo, D; Russo, F; Russo, G; del Genio, G; del Genio, A
2004-01-01
Pelvic abscesses represent the most frequent complications of colorectal surgery. Percutaneous CT or US guided drainage can be an alternative to surgical drainage that is associated to a significant mortality rate. In the current study results of PAD, performed in 39 patients with pelvic or abdominopelvic abscesses were reviewed in order to evaluate reliability of such procedure. Major part of the collections 33/39 (85%) developed after resective colorectal surgery, and 20/39 (51%) were associated to anastomotic fistula; 22/39 (56%) were poorly defined; 16/39 (41%) were multiloculated; 16/39 (41%) had a stool contamination, 23/39 (58%) were greater than 10 cm; 14/39 (35%) were multiple. Thirty-five patients (89.7%) healed, despite high number of complex abscesses and complete resolution of sepsis was achieved in 5.1 +/- 2.9 days. CT proved to be the most reliable tool in assessing distinctive features of collections as well as in identifying the best route for drainage. Adequate size of the catheter was essential to get an effective drainage. In particular, large sized catheter (> 20 Fr) had to be used to drain collections associated to anastomotic fistulas with stool contamination. In four elderly neoplastic patients with chronic illnesses (10%), only a single small sized catheter could be positioned, because of patients poor compliance and PAD was inaffective. Nevertheless even those patients got a partial resolution of the sepsis and their general conditions markedly improved, so that they were able to underwent successful surgical drainage. In conclusion PAD is a safe and reliable tool that can be employed as an alternative to surgical drainage at least as first measure, even if complex pelvic abscesses are found.
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Commerical Crew Astronauts Visit Launch Complex 39A
2018-03-27
Commercial Crew Program astronauts, from the left, Suni Williams, Eric Boe, Bob Behnken and Doug Hurley take in the view from the top of Launch Complex 39A at Kennedy Space Center. The astronauts toured the pad for an up-close look at modifications that are in work for the SpaceX Crew Dragon flight tests. Tower modifications included l removal of the space shuttle era rotating service structure. Future integration of the crew access arm will allow for safe crew entry for launch and exit from the spacecraft in the unlikely event a pad abort is required.
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Commerical Crew Astronauts Visit Launch Complex 39A
2018-03-27
Commercial Crew Program astronauts, from the left Doug Hurley, Eric Boe, Bob Behnken and Suni Williams, pose just outside Launch Complex 39A at NASA's Kennedy Space Center in Florida. The astronauts toured the pad for an up-close look at modifications that are in work for the SpaceX Crew Dragon flight tests. The tower modifications included removal of the space shuttle era rotating service structure. Future integration of the crew access arm will allow for safe crew entry for launch and exit from the spacecraft in the unlikely event a pad abort is required.
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Rare view of two space shuttles on adjacent KSC Launch Complex (LC) 39 pads
NASA Technical Reports Server (NTRS)
1990-01-01
Rare view shows two space shuttles on adjacent Kennedy Space Center (KSC) Launch Complex (LC) 39 pads with the Rotating Service Structures (RSS) retracted. STS-35 Columbia, Orbiter Vehicle (OV) 102, is on Pad A (foreground) and being readied for a September 6 early morning launch, while its sister spaceship, Discovery, OV-103, is prepared for an October liftoff on Mission STS-41. View provided by KSC with alternate number KSC-90PC-1268. Also see S90-48904 for a similar view with alternate KSC number KSC-90PC-1269.
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Identifying behaviour patterns of construction safety using system archetypes.
Guo, Brian H W; Yiu, Tak Wing; González, Vicente A
2015-07-01
Construction safety management involves complex issues (e.g., different trades, multi-organizational project structure, constantly changing work environment, and transient workforce). Systems thinking is widely considered as an effective approach to understanding and managing the complexity. This paper aims to better understand dynamic complexity of construction safety management by exploring archetypes of construction safety. To achieve this, this paper adopted the ground theory method (GTM) and 22 interviews were conducted with participants in various positions (government safety inspector, client, health and safety manager, safety consultant, safety auditor, and safety researcher). Eight archetypes were emerged from the collected data: (1) safety regulations, (2) incentive programs, (3) procurement and safety, (4) safety management in small businesses (5) production and safety, (6) workers' conflicting goals, (7) blame on workers, and (8) reactive and proactive learning. These archetypes capture the interactions between a wide range of factors within various hierarchical levels and subsystems. As a free-standing tool, they advance the understanding of dynamic complexity of construction safety management and provide systemic insights into dealing with the complexity. They also can facilitate system dynamics modelling of construction safety process. Copyright © 2015 Elsevier Ltd. All rights reserved.
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New Literacies and Multimediacy: The Immersive Universe of "The 39 Clues"
ERIC Educational Resources Information Center
Sekeres, Diane Carver; Watson, Christopher
2011-01-01
"The 39 Clues" (2009) is a multimedia series produced by Scholastic for readers 7-14 years old that includes printed texts released periodically; trading cards also published periodically in print and virtually; and a complex, intriguing, and entertaining website. To fully experience the multimedia series, the publishers expect that readers can…
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2010-12-17
CAPE CANAVERAL, Fla. -- Launch Complex 39 is seen across brackish water as the sun rises at NASA's Kennedy Space Center in Florida. On the left is Launch Pad 39B, which is being restructured for future use. On the right is Launch Pad 39A, where space shuttle Discovery is being prepared for a tanking test. Kennedy coexists with the Merritt Island National Wildlife Refuge, habitat to more than 310 species of birds, 25 mammals, 117 fish and 65 amphibians and reptiles. Photo credit: NASA/Frank Michaux
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Rare view of two space shuttles on adjacent KSC Launch Complex (LC) 39 pads
NASA Technical Reports Server (NTRS)
1990-01-01
Rare view shows two space shuttles on adjacent Kennedy Space Center (KSC) Launch Complex (LC) 39 pads with the Rotating Service Structures (RSS) retracted. STS-35 Columbia, Orbiter Vehicle (OV) 102, is on Pad A (foreground) is being readied for a September 6 early morning launch, while its sister spaceship, Discovery, OV-103, is set to begin preparations for an October liftoff on Mission STS-41. View provided by KSC with alternate number KSC-90PC-1269. Also see S90-48650 for similar view with alternate KSC number KSC-90PC-1268.
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NASA Technical Reports Server (NTRS)
Mata, Carlos T.; Rakov, V. A.; Mata, Angel G.
2010-01-01
A new Lightning Protection System (LPS) was designed and built at Launch Complex 39B (LC39B), at the Kennedy Space Center (KSC), Florida, which consists of a catenary wire system (at a height of about 181 meters above ground level) supported by three insulators installed atop three towers in a triangular configuration. A total of nine downconductors (each about 250 meters long, on average) are connected to the catenary wire system. Each of the nine downconductors is connected to a 7.62-meter radius circular counterpoise conductor with six equally spaced 6-meter long vertical grounding rods. Grounding requirements at LC39B call for all underground and above ground metallic piping, enclosures, raceways, and cable trays, within 7.62 meters of the counterpoise, to be bounded to the counterpoise, which results in a complex interconnected grounding system, given the many metallic piping, raceways, and cable trays that run in multiple direction around LC39B. The complexity of this grounding system makes the fall of potential method, which uses multiple metallic rods or stakes, unsuitable for measuring the grounding impedances of the downconductors. To calculate the downconductors grounding impedance, an Earth Ground Clamp (a stakeless grounding resistance measuring device) and a LPS Alternative Transient Program (ATP) model are used. The Earth Ground Clamp is used to measure the loop impedance plus the grounding impedance of each downconductor and the ATP model is used to calculate the loop impedance of each downconductor circuit. The grounding impedance of the downconductors is then calculated by subtracting the ATP calculated loop impedances from the Earth Ground Clamp measurements.
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NASA Astrophysics Data System (ADS)
Ryabkov, A. V.; Stafeeva, N. A.; Ivanov, V. A.; Zakuraev, A. F.
2018-05-01
A complex construction consisting of a universal floating pontoon road for laying pipelines in automatic mode on its body all year round and in any weather for Siberia and the Far North has been designed. A new method is proposed for the construction of pipelines on pontoon modules, which are made of composite materials. Pontoons made of composite materials for bedding pipelines with track-forming guides for automated wheeled transport, pipelayer, are designed. The proposed system eliminates the construction of a road along the route, ensures the buoyancy and smoothness of the self-propelled automated stacker in the form of a "centipede", which has a number of significant advantages in the construction and operation of the entire complex in the swamp and watered areas without overburden.
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Electronic construction collaboration system -- final phase : [tech transfer summary].
DOT National Transportation Integrated Search
2014-07-01
Construction projects have been growing more complex in terms of : project team composition, design aspects, and construction processes. : To help manage the shop/working drawings and requests for information : (RFIs) for its large, complex projects,...
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Prediction of cassava protein interactome based on interolog method.
Thanasomboon, Ratana; Kalapanulak, Saowalak; Netrphan, Supatcharee; Saithong, Treenut
2017-12-08
Cassava is a starchy root crop whose role in food security becomes more significant nowadays. Together with the industrial uses for versatile purposes, demand for cassava starch is continuously growing. However, in-depth study to uncover the mystery of cellular regulation, especially the interaction between proteins, is lacking. To reduce the knowledge gap in protein-protein interaction (PPI), genome-scale PPI network of cassava was constructed using interolog-based method (MePPI-In, available at http://bml.sbi.kmutt.ac.th/ppi ). The network was constructed from the information of seven template plants. The MePPI-In included 90,173 interactions from 7,209 proteins. At least, 39 percent of the total predictions were found with supports from gene/protein expression data, while further co-expression analysis yielded 16 highly promising PPIs. In addition, domain-domain interaction information was employed to increase reliability of the network and guide the search for more groups of promising PPIs. Moreover, the topology and functional content of MePPI-In was similar to the networks of Arabidopsis and rice. The potential contribution of MePPI-In for various applications, such as protein-complex formation and prediction of protein function, was discussed and exemplified. The insights provided by our MePPI-In would hopefully enable us to pursue precise trait improvement in cassava.
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Jacobi bundles and the BFV-complex
NASA Astrophysics Data System (ADS)
Lê, Hông Vân; Tortorella, Alfonso G.; Vitagliano, Luca
2017-11-01
We extend the construction of the BFV-complex of a coisotropic submanifold from the Poisson setting to the Jacobi setting. In particular, our construction applies in the contact and l.c.s. settings. The BFV-complex of a coisotropic submanifold S controls the coisotropic deformation problem of S under both Hamiltonian and Jacobi equivalence.
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NASA Technical Reports Server (NTRS)
Mata, C. T.; Mata, A. G.; Rakov, V. A.; Nag, A.; Saul, J.
2012-01-01
A new comprehensive lightning instrumentation system has been designed for Launch Complex 39B (LC39B) at the Kennedy Space Center, Florida. This new instrumentation system includes seven synchronized high-speed video cameras, current sensors installed on the nine downconductors of the new lightning protection system (LPS) for LC39B; four dH/dt, 3-axis measurement stations; and five dE/dt stations composed of two antennas each. The LPS received 8 direct lightning strikes (a total of 19 strokes) from March 31 through December 31 2011. The measured peak currents and locations are compared to those reported by the Cloud-to-Ground Lightning Surveillance System (CGLSS II) and the National Lightning Detection Network (NLDN). Results of comparison are presented and analyzed in this paper.
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Sorrel, Amy Lynn
2014-07-01
As governments and employers look for ways to curb growing health care costs, and as patients bear a higher share of their medical bills, policymakers in Texas and beyond increasingly target physicians in their efforts to unveil health care prices. They couch such "price transparency" as a way to help patients make more informed health care decisions. But Texas Medical Association's Board of Trustees member Gary W. Floyd, MD, of Fort Worth, cautions that for a complex health care payment system, coupled with individual patients' complex needs, coming up with a so-called "sticker price" is not as simple as it seems.
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NASA Technical Reports Server (NTRS)
Price, P. B.
1978-01-01
The feasibility of the design, construction, launch and retrieval of a hinged 15 ft by 110 ft the platform containing an array of interleaved CR-39 and Lexan track-recording detectors to be placed into circular orbit by space shuttle is assessed. The total weight of the detector assembly plus supporting structure and accessories is 32,000 pounds. The modular construction permits as little as one fourth of the payload to be exposed at one time. The CR-39 detector has sensitivity adequate to detect and study cosmic rays ranging from minimum ionizing iron-group nuclei to the heaviest elements. The detectors will survive a one year exposure to trapped protons without losing their high resolution. Advantages include low cost, huge collecting power (approximately 150 sq m) as well as the high resolution previously attainable only with electronic detectors.
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van der Kant, Rik; Jonker, Caspar T. H.; Wijdeven, Ruud H.; Bakker, Jeroen; Janssen, Lennert; Klumperman, Judith; Neefjes, Jacques
2015-01-01
Trafficking of cargo through the endosomal system depends on endosomal fusion events mediated by SNARE proteins, Rab-GTPases, and multisubunit tethering complexes. The CORVET and HOPS tethering complexes, respectively, regulate early and late endosomal tethering and have been characterized in detail in yeast where their sequential membrane targeting and assembly is well understood. Mammalian CORVET and HOPS subunits significantly differ from their yeast homologues, and novel proteins with high homology to CORVET/HOPS subunits have evolved. However, an analysis of the molecular interactions between these subunits in mammals is lacking. Here, we provide a detailed analysis of interactions within the mammalian CORVET and HOPS as well as an additional endosomal-targeting complex (VIPAS39-VPS33B) that does not exist in yeast. We show that core interactions within CORVET and HOPS are largely conserved but that the membrane-targeting module in HOPS has significantly changed to accommodate binding to mammalian-specific RAB7 interacting lysosomal protein (RILP). Arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome-associated mutations in VPS33B selectively disrupt recruitment to late endosomes by RILP or binding to its partner VIPAS39. Within the shared core of CORVET/HOPS, we find that VPS11 acts as a molecular switch that binds either CORVET-specific TGFBRAP1 or HOPS-specific VPS39/RILP thereby allowing selective targeting of these tethering complexes to early or late endosomes to time fusion events in the endo/lysosomal pathway. PMID:26463206
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Payload Bay Canister being transported to Pad 39A for a fit chec
2007-01-22
This payload canister is being transported to Launch Pad 39A for a "fit check." At a later date, the canister will be used to transport to the pad the S3/S4 solar arrays that are the payload for mission STS-117. The mission will launch on Space Shuttle Atlantis for the 21st flight to the International Space Station, and the crew of six will continue the construction of station with the installation of the arrays. The launch of Atlantis is targeted for March 16.
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2008-12-19
CAPE CANAVERAL, Fla. -- On Launch Pad 39B at NASA's Kennedy Space Center in Florida, one of the new lightning towers is under construction. The towers will hold catenary wires as part of the new lightning protection system for the Constellation Program and Ares/Orion launches. Pad 39B will be the site of the first Ares vehicle launch, including Ares I-X test flight that is targeted for July 2009. Photo credit: NASA/Tim Jacobs
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Richardson, Miles; Hunt, Thomas E; Richardson, Cassandra
2014-12-01
This paper presents a methodology to control construction task complexity and examined the relationships between construction performance and spatial and mathematical abilities in children. The study included three groups of children (N = 96); ages 7-8, 10-11, and 13-14 years. Each group constructed seven pre-specified objects. The study replicated and extended previous findings that indicated that the extent of component symmetry and variety, and the number of components for each object and available for selection, significantly predicted construction task difficulty. Results showed that this methodology is a valid and reliable technique for assessing and predicting construction play task difficulty. Furthermore, construction play performance predicted mathematical attainment independently of spatial ability.
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Liu, Jingkuang; Gong, Enqin; Wang, Dong; Lai, XiaoHong; Zhu, Jian
2018-05-21
With the spread of the concept of sustainable development, people have gained awareness about the problem of massive illegal dumping of construction waste. In this research, a questionnaire survey was carried out in the USA and China. The results indicated the following. (1) Workers in both the countries had positive minimisation attitudes, and the attitude of Chinese construction workers was not significantly different from that of American construction workers. Furthermore, their average values were 3.9 and 4.07, respectively. (2) Business owners had a poor understanding of the obligations that should be fulfilled by contractors and construction workers, which greatly reduced (a) construction workers' and contractors' motivation to implement waste minimisation management and (b) the benefit-driven effect. (3) In terms of perceived behavioural control, Chinese construction workers had poorer minimisation technologies and knowledge than American construction workers, and it was very difficult for them to implement construction waste minimisation. The research conclusions and relevant suggestions may be used to improve the construction waste minimisation behaviour and awareness of Chinese people and promote China's construction waste minimisation management.
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2014-04-11
CAPE CANAVERAL, Fla. - Construction of an exercise pad is underway beside the new fitness trail next to the Space Station Processing Facility at NASA's Kennedy Space Center in Florida. The one-mile-long track will provide employees with a safe place off Kennedy's roadways to walk or run. The more than 6 tons of green waste removed to create the trail's footprint will be mulched and used for cover at Kennedy's landfill. Approximately 1,594 tons of crawler fines -- ground-up crawler rock removed from the crawlerway in the Launch Complex 39 area -- was used for the foundation of the trail. Fitness equipment has been ordered and will be installed on a concrete slab at the trail's west end. After the equipment has been installed, the slab will be coated to provide a rubberized exercise pad. At Kennedy Space Center, the health and safety of every employee is paramount. To learn more about Kennedy, visit http://www.nasa.gov/kennedy. Photo credit: NASA/Frankie Martin
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NASA Technical Reports Server (NTRS)
Joyner, James J., Sr.
2014-01-01
Develop Survivability vs Time Model as a decision-evaluation tool to assess various emergency egress methods used at Launch Complex 39B (LC 39B) and in the Vehicle Assembly Building (VAB) on NASAs Kennedy Space Center. For each hazard scenario, develop probability distributions to address statistical uncertainty resulting in survivability plots over time and composite survivability plots encompassing multiple hazard scenarios.
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Early and Late Alkali Igneous Pulses and a High-3He Plume Origin for the Deccan Flood Basalts.
Basu, A R; Renne, P R; Dasgupta, D K; Teichmann, F; Poreda, R J
1993-08-13
Several alkalic igneous complexes of nephelinite-carbonatite affinities occur in extensional zones around a region of high heat flow and positive gravity anomaly within the continental flood basalt (CFB) province of Deccan, India. Biotites from two of the complexes yield (40)Ar/(39)Ar dates of 68.53 +/- 0.16 and 68.57 +/- 0.08 million years. Biotite from a third complex, which intrudes the flood basalts, yields an (40)Ar/(39)Ar date of 64.96 +/- 0.1 1 million years. The complexes thus represent early and late magmatism with respect to the main pulse of CFB volcanism 65 million years ago. Rocks from the older complexes show a (3)He/(4)He ratio of 14.0 times the air ratio, an initial (87)Sr/(86)Sr ratio of 0.70483, and other geochemical characteristics similar to ocean island basalts; the later alkalic pulse shows isotopic evidence of crustal contamination. The data document 3.5 million years of incubation of a primitive, high-(3)He mantle plume before the rapid eruption of the Deccan CFB.
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Rare view of two space shuttles on adjacent KSC Launch Complex (LC) 39 pads
1990-09-05
S90-48650 (5 Sept 1990) --- This rare view shows two space shuttles on adjacent pads at Launch Complex 39 with the Rotating Service Structures (RSR) retracted. Space Shuttle Columbia (foreground) is on Pad A where it awaits further processing for a September 6 early morning launch on STS-35. Discovery, its sister spacecraft, is set to begin preparations for an October liftoff on STS-41 when the Ulysses spacecraft is scheudled to be taxied into space. PLEASE NOTE: Following the taking of this photograph, STS-35 was postponed and STS-41's Discovery was successfully launched on Oct. 6.
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Sisson, V.B.; Ave Lallemant, H.G.; Ostos, M.; Blythe, A.E.; Snee, L.W.; Copeland, Peter; Wright, J.E.; Donelick, R.A.; Guth, L.R.
2005-01-01
The margin of northern Venezuela is a complex zone representing the orogenic events from basement formation to subsequent subduction and exhumation during transpressional collision. This boundary zone has six east-west-trending belts that each record a different segment of its development. This geologic complexity requires radiometric ages to unravel, and we herein provide 48 new ages including U-Pb (4), Rb-Sr (2), 40Ar/39Ar (24), zircon and apatite fission-track (17), and 14C (1) ages to constrain the evolution of three of these belts. These three belts are the Cordillera de la Costa, Caucagua-El Tinaco, and Serran??a del Interior belts. In the Cordillera de la Costa belt, U-Pb geochronologic data indicate portions of the basement igneous and metaigneous rocks formed in the Cambro-Ordovician (513-471 Ma). New 40Ar/39Ar data from Margarita Island indicate that some of the subduction complex was rapidly cooled and exhumed, whereas other portions indicate slower cooling. This contrasts with new 40Ar/39Ar data from the Puerto Cabello. ?? 2005 Geological Society of America.
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Le, Duc-Hau
2015-01-01
Protein complexes formed by non-covalent interaction among proteins play important roles in cellular functions. Computational and purification methods have been used to identify many protein complexes and their cellular functions. However, their roles in terms of causing disease have not been well discovered yet. There exist only a few studies for the identification of disease-associated protein complexes. However, they mostly utilize complicated heterogeneous networks which are constructed based on an out-of-date database of phenotype similarity network collected from literature. In addition, they only apply for diseases for which tissue-specific data exist. In this study, we propose a method to identify novel disease-protein complex associations. First, we introduce a framework to construct functional similarity protein complex networks where two protein complexes are functionally connected by either shared protein elements, shared annotating GO terms or based on protein interactions between elements in each protein complex. Second, we propose a simple but effective neighborhood-based algorithm, which yields a local similarity measure, to rank disease candidate protein complexes. Comparing the predictive performance of our proposed algorithm with that of two state-of-the-art network propagation algorithms including one we used in our previous study, we found that it performed statistically significantly better than that of these two algorithms for all the constructed functional similarity protein complex networks. In addition, it ran about 32 times faster than these two algorithms. Moreover, our proposed method always achieved high performance in terms of AUC values irrespective of the ways to construct the functional similarity protein complex networks and the used algorithms. The performance of our method was also higher than that reported in some existing methods which were based on complicated heterogeneous networks. Finally, we also tested our method with prostate cancer and selected the top 100 highly ranked candidate protein complexes. Interestingly, 69 of them were evidenced since at least one of their protein elements are known to be associated with prostate cancer. Our proposed method, including the framework to construct functional similarity protein complex networks and the neighborhood-based algorithm on these networks, could be used for identification of novel disease-protein complex associations.
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Yokozaki, H; Tahara, H; Oue, N; Tahara, E
2000-01-01
A new transcription variant of hepatocyte growth factor/scatter factor (HGF/SF) was cloned from human gastric cancer cell line HSC-39. Northern blot analysis of eight human gastric cancer cell lines (TMK-1, MKN-1, MKN-7, MKN-28, MKN-45, MKN-74, KATO-III and HSC-39) demonstrated that HSC-39 cells expressed a 1.3 kb abnormal HGF/SF transcript. Screening of 1 x 10(6) colonies of cDNA library from HSC-39 constructed in pAP3neo mammalian expression vector selected four positive clones containing HGF/SF transcript. Among them, two contained a 1.3 kbp insert detecting the identical transcript to that obtained with HGF/SF probe by Northern blotting. Deoxynucleotide sequencing of the 1.3 kbp insert revealed that it was composed of a part of HGF/SF cDNA from exon 14 to exon 18, corresponding to the whole sequence of HGF/SF light chain, with 5' 75 nucleotides unrelated to any sequence involved in HGF/SF.
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Computer Implementation of the Bounding Surface Plasticity Model for Cohesive Soils.
1983-12-01
Contract # DACA 39-79-M-0059), the Civil Engineering Laboratory, Naval Construction Battalion Center (Re: Orders N62583-80-M-R478, N62583-81-M- R320, N62#74...correspondinga a expression in the equation of "Modification 5" (Section 1) is treated in a similar fashion. In general, this arbitrary action does not...Contract # DACA 39-79-M-0059), April 1980. 3. Dafalias, Y.F., L.R. Herrmann and J.S. DeNatale, "Prediction of the Response of the Natural Clays X and Y
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2009-01-26
CAPE CANAVERAL, Fla. – On Launch Pad 39B at NASA's Kennedy Space Center in Florida, a crane begins lifting a 100-foot fiberglass lightning mast to place it on top of one of the 500-foot towers being constructed for the Constellation Program and Ares/Orion launches. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009.
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2009-01-26
CAPE CANAVERAL, Fla. – On Launch Pad 39B at NASA's Kennedy Space Center in Florida, a crane begins lifting a 100-foot fiberglass lightning mast to place it on top of one of the 500-foot towers being constructed for the Constellation Program and Ares/Orion launches. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009.
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2009-01-26
CAPE CANAVERAL, Fla. – On Launch Pad 39B at NASA's Kennedy Space Center in Florida, a crane lifts a 100-foot fiberglass lightning mast that will be placed on top of one of the 500-foot towers being constructed for the Constellation Program and Ares/Orion launches. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009.
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2009-01-26
CAPE CANAVERAL, Fla. – On Launch Pad 39B at NASA's Kennedy Space Center in Florida, a crane lifts a 100-foot fiberglass lightning mast alongside the 500-foot tower where it will be installed. The tower is one of three being constructed for the Constellation Program and Ares/Orion launches. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009.
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2009-01-26
CAPE CANAVERAL, Fla. – On Launch Pad 39B at NASA's Kennedy Space Center in Florida, a crane places a 100-foot fiberglass lightning mast on top of the 500-foot tower. The tower is one of three being constructed for the Constellation Program and Ares/Orion launches. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009. Photo credit: NASA/Jack Pfaller
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2009-01-26
CAPE CANAVERAL, Fla. – On Launch Pad 39B at NASA's Kennedy Space Center in Florida, a crane holds a 100-foot fiberglass lightning mast that will be placed on top of one of the 500-foot towers being constructed for the Constellation Program and Ares/Orion launches. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009.
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2009-01-26
CAPE CANAVERAL, Fla. – On Launch Pad 39B at NASA's Kennedy Space Center in Florida, a crane places a 100-foot fiberglass lightning mast on top of the 500-foot tower. The tower is one of three being constructed for the Constellation Program and Ares/Orion launches. Another tower is seen at right. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009.
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Pedicle screw versus hybrid posterior instrumentation for dystrophic neurofibromatosis scoliosis.
Wang, Jr-Yi; Lai, Po-Liang; Chen, Wen-Jer; Niu, Chi-Chien; Tsai, Tsung-Ting; Chen, Lih-Huei
2017-06-01
Surgical management of severe rigid dystrophic neurofibromatosis (NF) scoliosis is technically demanding and produces varying results. In the current study, we reviewed 9 patients who were treated with combined anterior and posterior fusion using different types of instrumentation (i.e., pedicle screw, hybrid, and all-hook constructs) at our institute.Between September 2001 and July 2010 at our institute, 9 patients received anterior release/fusion and posterior fusion with different types of instrumentation, including a pedicle screw construct (n = 5), a hybrid construct (n = 3), and an all-hook construct (n = 1). We compared the pedicle screw group with the hybrid group to analyze differences in preoperative curve angle, immediate postoperative curve reduction, and latest follow-up curve angle.The mean follow-up period was 9.5 ± 2.9 years. The average age at surgery was 10.3 ± 3.9 years. The average preoperative scoliosis curve was 61.3 ± 13.8°, and the average preoperative kyphosis curve was 39.8 ± 19.7°. The average postoperative scoliosis and kyphosis curves were 29.7 ± 10.7° and 21.0 ± 13.5°, respectively. The most recent follow-up scoliosis and kyphosis curves were 43.4 ± 17.3° and 29.4 ± 18.9°, respectively. There was no significant difference in the correction angle (either coronal or sagittal), and there was no significant difference in the loss of sagittal correction between the pedicle screw construct group and the hybrid construct group. However, the patients who received pedicle screw constructs had significantly less loss of coronal correction (P < .05). Two patients with posterior instrumentation, one with an all-hook construct and the other with a hybrid construct, required surgical revision because of progression of deformity.It is difficult to intraoperatively correct dystrophic deformity and to maintain this correction after surgery. Combined anterior release/fusion and posterior fusion using either a pedicle screw construct or a hybrid construct provide similar curve corrections both sagittally and coronally. After long-term follow-up, sagittal correction was maintained with both constructs. However, patients treated with posterior instrumentation using pedicle screw constructs had significantly less loss of coronal correction.
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Pedicle screw versus hybrid posterior instrumentation for dystrophic neurofibromatosis scoliosis
Wang, Jr-Yi; Lai, Po-Liang; Chen, Wen-Jer; Niu, Chi-Chien; Tsai, Tsung-Ting; Chen, Lih-Huei
2017-01-01
Abstract Surgical management of severe rigid dystrophic neurofibromatosis (NF) scoliosis is technically demanding and produces varying results. In the current study, we reviewed 9 patients who were treated with combined anterior and posterior fusion using different types of instrumentation (i.e., pedicle screw, hybrid, and all-hook constructs) at our institute. Between September 2001 and July 2010 at our institute, 9 patients received anterior release/fusion and posterior fusion with different types of instrumentation, including a pedicle screw construct (n = 5), a hybrid construct (n = 3), and an all-hook construct (n = 1). We compared the pedicle screw group with the hybrid group to analyze differences in preoperative curve angle, immediate postoperative curve reduction, and latest follow-up curve angle. The mean follow-up period was 9.5 ± 2.9 years. The average age at surgery was 10.3 ± 3.9 years. The average preoperative scoliosis curve was 61.3 ± 13.8°, and the average preoperative kyphosis curve was 39.8 ± 19.7°. The average postoperative scoliosis and kyphosis curves were 29.7 ± 10.7° and 21.0 ± 13.5°, respectively. The most recent follow-up scoliosis and kyphosis curves were 43.4 ± 17.3° and 29.4 ± 18.9°, respectively. There was no significant difference in the correction angle (either coronal or sagittal), and there was no significant difference in the loss of sagittal correction between the pedicle screw construct group and the hybrid construct group. However, the patients who received pedicle screw constructs had significantly less loss of coronal correction (P < .05). Two patients with posterior instrumentation, one with an all-hook construct and the other with a hybrid construct, required surgical revision because of progression of deformity. It is difficult to intraoperatively correct dystrophic deformity and to maintain this correction after surgery. Combined anterior release/fusion and posterior fusion using either a pedicle screw construct or a hybrid construct provide similar curve corrections both sagittally and coronally. After long-term follow-up, sagittal correction was maintained with both constructs. However, patients treated with posterior instrumentation using pedicle screw constructs had significantly less loss of coronal correction. PMID:28562548
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Active Cdk5 Immunoprecipitation and Kinase Assay
Bankston, Andrew N.; Ku, Li; Feng, Yue
2017-01-01
Cdk5 activity is regulated by the amounts of two activator proteins, p35 and p39 (Tsai et al., 1994; Zheng et al., 1998; Humbert et al., 2000). The p35-Cdk5 and p39-Cdk5 complexes have differing sensitivity to salt and detergent concentrations (Hisanaga and Saito, 2003; Sato et al., 2007; Yamada et al., 2007; Asada et al., 2008). Cdk5 activation can be directly measured by immunoprecipitation of Cdk5 with its bound activator, followed by a Cdk5 kinase assay. In this protocol, buffers for cell lysis and immunoprecipitation are intended to preserve both p35- and p39-Cdk5 complexes to assess total Cdk5 activity. Cells are lysed and protein concentration is determined in the post-nuclear supernatant. Cdk5 is immunoprecipitated from equal amounts of total protein between experimental groups. Washes are then performed to remove extraneous proteins and equilibrate the Cdk5-activator complexes in the kinase buffer. Cdk5 is then incubated with histone H1, a well-established in vitro target of Cdk5, and [γ-32P]ATP. Reactions are resolved by SDS-PAGE and transferred to membranes for visualization of H1 phosphorylation and immunoblot of immunoprecipitated Cdk5 levels. We have used this assay to establish p39 as the primary activator for Cdk5 in the oligodendroglial lineage. However, this assay is amenable to other cell lineages or tissues with appropriate adjustments made to lysis conditions. PMID:28868329
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Biofabricated constructs as tissue models: a short review.
Costa, Pedro F
2015-04-01
Biofabrication is currently able to provide reliable models for studying the development of cells and tissues into multiple environments. As the complexity of biofabricated constructs is becoming increasingly higher their ability to closely mimic native tissues and organs is also increasing. Various biofabrication technologies currently allow to precisely build cell/tissue constructs at multiple dimension ranges with great accuracy. Such technologies are also able to assemble together multiple types of cells and/or materials and generate constructs closely mimicking various types of tissues. Furthermore, the high degree of automation involved in these technologies enables the study of large arrays of testing conditions within increasingly smaller and automated devices both in vitro and in vivo. Despite not yet being able to generate constructs similar to complex tissues and organs, biofabrication is rapidly evolving in that direction. One major hurdle to be overcome in order for such level of complex detail to be achieved is the ability to generate complex vascular structures within biofabricated constructs. This review describes several of the most relevant technologies and methodologies currently utilized within biofabrication and provides as well a brief overview of their current and future potential applications.
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Tricolor microcavity OLEDs based on P-nc-Si:H films as the complex anodes
NASA Astrophysics Data System (ADS)
Yang, Li; Xingyuan, Liu; Chunya, Wu; Zhiguo, Meng; Yi, Wang; Shaozhen, Xiong
2009-06-01
A P+-nc-Si:H film (boron-doped nc-Si:H thin film) was used as a complex anode of an OLED. As an ideal candidate for the composite anode, the P+-nc-Si:H thin film has a good conductivity with a high work function (~ 5.7 eV) and outstanding optical properties of high reflectivity, transmission, and a very low absorption. As a result, the combination of the relatively high reflectivity of a P+-nc-Si:H film/ITO complex anode with the very high reflectivity of an Al cathode could form a micro-cavity structure with a certain Q to improve the efficiency of the OLED fabricated on it. An RGB pixel generated by microcavity OLEDs is beneficial for both the reduction of the light loss and the improvement of the color purity and the efficiency. The small molecule Alq would be useful for the emitting light layer (EML) of the MOLED, and the P+-nc-Si film would be used as a complex anode of the MOLED, whose configuration can be constructed as Glass/LTO/P+-nc-Si:H/ITO/MoO3/NPB/Alq/LiF/Al. By adjusting the thickness of the organic layer NPB/Alq, the optical length of the microcavity and the REB colors of the device can be obtained. The peak wavelengths of an OLED are located at 486, 550, and 608 nm, respectively. The CIE coordinates are (0.21, 0.45), (0.33, 0.63), and (0.54, 0.54), and the full widths at half maximum (FWHM) are 35, 32, and 39 nm for red, green, and blue, respectively.
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39. VIEW LOOKING NORTH INTO THE REAR OF THE BUILDING ...
39. VIEW LOOKING NORTH INTO THE REAR OF THE BUILDING COMPLEX AND SERVICE COURT. (NOTE: HISTORIC JAPANESE FALSE CYPRESS AND HINOKI FALSE CYPRESS IN CENTER; FRAMING FOR BLUEPRINT PRODUCTION EVIDENT ON SECOND STORY OF OFFICE WING TO LEFT). - Fairsted, 99 Warren Street, Brookline, Norfolk County, MA
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Assessing problem-solving skills in construction education with the virtual construction simulator
NASA Astrophysics Data System (ADS)
Castronovo, Fadi
The ability to solve complex problems is an essential skill that a construction and project manager must possess when entering the architectural, engineering, and construction industry. Such ability requires a mixture of problem-solving skills, ranging from lower to higher order thinking skills, composed of cognitive and metacognitive processes. These skills include the ability to develop and evaluate construction plans and manage the execution of such plans. However, in a typical construction program, introducing students to such complex problems can be a challenge, and most commonly the learner is presented with only part of a complex problem. To support this challenge, the traditional methodology of delivering design, engineering, and construction instruction has been going through a technological revolution, due to the rise of computer-based technology. For example, in construction classrooms, and other disciplines, simulations and educational games are being utilized to support the development of problem-solving skills. Previous engineering education research has illustrated the high potential that simulations and educational games have in engaging in lower and higher order thinking skills. Such research illustrated their capacity to support the development of problem-solving skills. This research presents evidence supporting the theory that educational simulation games can help with the learning and retention of transferable problem-solving skills, which are necessary to solve complex construction problems. The educational simulation game employed in this study is the Virtual Construction Simulator (VCS). The VCS is a game developed to provide students in an engaging learning activity that simulates the planning and managing phases of a construction project. Assessment of the third iteration of the VCS(3) game has shown pedagogical value in promoting students' motivation and a basic understanding of construction concepts. To further evaluate the benefits on problem-solving skills, a new version of the VCS(4) was developed, with new building modules and assessment framework. The design and development of the VCS4 leveraged research in educational psychology, multimedia learning, human-computer interaction, and Building Information Modeling. In this dissertation the researcher aimed to evaluate the pedagogical value of the VCS4 in fostering problem-solving skills. To answer the research questions, a crossover repeated measures quasi-experiment was designed to assess the educational gains that the VCS can provide to construction education. A group of 34 students, attending a fourth-year construction course at a university in the United States was chosen to participate in the experiment. The three learning modules of the VCS were used, which challenged the students to plan and manage the construction process of a wooden pavilion, the steel erection of a dormitory, and the concrete placement of the same dormitory. Based on the results the researcher was able to provide evidence supporting the hypothesis that the chosen sample of construction students were able to gain and retain problem-solving skills necessary to solve complex construction simulation problems, no matter what the sequence with which these modules were played. In conclusion, the presented results provide evidence supporting the theory that educational simulation games can help the learning and retention of transferable problem-solving skills, which are necessary to solve complex construction problems.
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2011-01-20
CAPE CANAVERAL, Fla. -- NASA's Kennedy Space Center in Florida hosts a ribbon-cutting ceremony for the space agency's most environmentally friendly facility, the Propellants North Administrative and Maintenance Facility in Kennedy's Launch Complex 39 area. From left, are Mike Benik, director of Kennedy's Center Operations; James Wright, deputy assistant administrator for the Office of Strategic Infrastructure at NASA Headquarters; Bob Cabana, Kennedy's center director; Ward Davis, president of HW Davis Construction Inc.; and Rick Ferreira, chief operating officer of Jones Edmunds and Associates Inc. Propellants North consists of two buildings, one to store cryogenic fuel transfer equipment and one to house personnel who support fueling spacecraft. The recently rebuilt buildings will be NASA's first carbon neutral facility, which means it will produce enough energy on site from renewable sources to offset what it requires to operate. The facility also will reach for the U.S. Green Building Council's Leadership in Environmental and Energy Design (LEED) Platinum status, which is the highest LEED rating. Photo credit: NASA/Kim Shiflett
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2006-03-24
KENNEDY SPACE CENTER, FLA. -- With the ribbon-cutting ceremony, the new Operations Support Building II is officially in business. Participating in the event are (left to right) Aris Garcia, vice president of the architecture firm Wolfgang Alvarez; Mark Nappi, associate program manager of Ground Operations for United Space Alliance; Donald Minderman, NASA project manager; Scott Kerr, director of Engineering Development at Kennedy; Bill Parsons, deputy director of Kennedy Space Center; Miguel Morales, with NASA Engineering Development; Mike Wetmore, director of Shuttle Processing; and Tim Clancy, president of the construction firm Clancy & Theys. The Operations Support Building II is an Agency safety and health initiative project to replace 198,466 square feet of substandard modular housing and trailers in the Launch Complex 39 area at Kennedy Space Center. The five-story building, which sits south of the Vehicle Assembly Building and faces the launch pads, includes 960 office spaces, 16 training rooms, computer and multimedia conference rooms, a Mission Conference Center with an observation deck, technical libraries, an Exchange store, storage, break areas, and parking. Photo credit: NASA/George Shelton
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7 CFR 1753.39 - Closeout documents.
Code of Federal Regulations, 2010 CFR
2010-01-01
..., 1400 Independence Ave., SW., Washington, DC 20250-1522. (d) Grounding system audit. A grounding system audit shall be performed and found acceptable for equipment provided under Form 525 and 545 Contracts... AGRICULTURE TELECOMMUNICATIONS SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Purchase and Installation of...
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75 FR 34004 - State Cemetery Grants
Federal Register 2010, 2011, 2012, 2013, 2014
2010-06-16
... architectural design codes that apply to grant applicants, we decided to update those references in a separate.... 39.63 Architectural design standards. Subpart C--Operation and Maintenance Projects Grant... acquisition, design and planning, earth moving, landscaping, construction, and provision of initial operating...
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An Approximately 4.35 Ga Ar-Ar Age for GRA 8 and the Complex Chronology of its Parent Body
NASA Technical Reports Server (NTRS)
Park, J.; Nyquist, Laurence E.; Bogard, D. D.; Garrison, D. H.; Shih, C.-Y.; Reese, Y. D.
2010-01-01
GRA06128 and GRA06129 (hereafter GRA 8 and GRA 9) are partial melts of a parent body of approximately chondritic composition. We reported a conventional Sm-147-Nd-143 isochron age of 4.559+/-0.096 Ga and a 146 Sm-142Nd model age of 4.549+/-0.036 for combined data for the two rocks. Plagioclase plus whole rock and leachate (approx.phosphate) samples gave a secondary Sm-147-Nd-143 age of 3.4+/-0.4 Ga. An Ar-39-Ar-40 age of 4.460+/-0.028 Ga was interpreted as dating metamorphism in GRA 9. We report Ar-39-Ar-40 ages in the range approx.4344-4366 Ma for GRA 8, establishing similar but different Ar-39-Ar-40 ages for the two rocks, consistent with their different Sr-isotopic systematics, and discuss these ages in the context of the complex sequence of events that affected these samples.
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An Approximately 4.35 Ga Ar-Ar Age for GRA 8 and the Complex Chronology of its Parent Body
NASA Technical Reports Server (NTRS)
Park, J.; Nyquist, L. E.; Bogard, D. D.; Garrison, D. H.; Shih, C.-Y.; Reese, Y. D.
2010-01-01
GRA06128 and GRA06129 (hereafter GRA 8 and GRA 9) are partial melts of a parent body of approximately chondritic composition. We reported a conventional SM-147Sm-ND_143 isochron age of 4.559 +/-.096 Ga and a SM-146-142Nd model age of 4.549 +/- 0.036 for combined data for the two rocks. Plagioclase plus whole rock and leachate (approximately phosphate) samples gave a secondary SM-147-ND-143 age of 3.4 +/-0.4 Ga. An Ar-39-Ar-40 age of 4.460+/-0.028 Ga was interpreted by as dating metamorphism in GRA 9. We report Ar-39-Ar-40 ages in the range approximately 4344-4366 Ma for GRA 8, establishing similar but different Ar-39-Ar-40 ages for the two rocks, consistent with their different Sr-istopic systematics, and discuss these ages in the context of the complex sequence of events that affected these samples
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Planning and evaluation parameters for offshore complexes
NASA Technical Reports Server (NTRS)
Sincoff, M. Z. (Editor); Dajani, J. S. (Editor)
1976-01-01
Issues are presented for consideration in the planning and design of offshore artificial complexes. The construction of such complexes, their social, economic, and ecological impacts, and the legal-political-institutional environments within which their development could occur, are discussed. Planning, design, and construction of near-shore complexes located off the Mid-Atlantic coast of the United States is emphasized.
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Constructing a Reference Event List for ARCESS
1993-08-25
4/5/91 12:12:421 2.32 HK3 EXP F 24 17743 4/10/91 12:25:08.5 2.26 HK3 EXP F 26 20049 4/26/91 12-39:523 2.32 HK3 EXP F 27 20449 4/30/91 12:3^:46.5... 20449 4/30/91 12:34:46.5 69.3087 30.8716 3.44 F 29 24872 5/31/91 12:39:13.9 69.4000 30.7861 2.41 F 30 25681 6/5/91 12:30:59.7 69.3319 30.9285 2.28
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2013-06-12
CAPE CANAVERAL, Fla. – At Launch Pad 39B at NASA’s Kennedy Space Center in Florida, crawler track panels have been removed from the surface and construction workers are repairing the concrete surface and catacomb roof below. Launch Pad 39B is being refurbished to support NASA’s Space Launch System and other launch vehicles. The Ground Systems Development and Operations, or GSDO, Program office at Kennedy is leading the center’s transformation to safely handle a variety of rockets and spacecraft. For more information about GSDO, visit: http://go.nasa.gov/groundsystems. Photo credit: NASA/Jim Grossman
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Aerial view of Launch Complex 39
NASA Technical Reports Server (NTRS)
1998-01-01
In this aerial view looking south can be seen Launch Complex (LC) 39 area, where assembly, checkout and launch of the Space Shuttle Orbiter and its External Tank and twin Solid Rocket Boosters take place. Central to the complex is the tallest building at the center, the Vehicle Assembly Building (VAB). To the immediate left, from top to bottom, are the Orbiter Processing Facility (OPF) High Bay 3 and new engine shop (north side), OPF Modular Office Building, Thermal Protection System Facility, and a crawler-transporter (to its left). In front of the VAB are OPF 1 and OPF 2. At right is the Processing Control Center. West of OPF 3 is the Mobile Launch Platform. In the upper left corner is Launch Pad B; at the far right is the turn basin, with the Press Site located just below it to the right.
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Dissociative complexity: Antecedents and clinical correlates of a new construct.
Briere, John; Dietrich, Anne; Semple, Randye J
2016-09-01
To the extent that dissociation is a multidimensional phenomenon, and given a growing literature on complex posttraumatic outcomes, we hypothesized a new construct: dissociative complexity (DC). DC is defined as the tendency to simultaneously endorse multiple, relatively independent dissociative dimensions into their clinical ranges, and therefore represents the overall breadth or complexity of an individual's dissociative response. DC was evaluated in general population and prison participants using the Multiscale Dissociation Inventory (MDI; Briere, 2002). DC was higher among prisoners and women, and, as hypothesized, was associated with cumulative trauma and serious comorbidities (suicidality and substance abuse), even when controlling for generally elevated dissociation. DC appears to be a meaningful clinical construct that is phenomenologically and empirically different from a unidimensional index of dissociative severity. DC may serve as a clinical marker for multiple trauma exposures, complex dissociative outcomes, and risk of problematic comorbidities. (PsycINFO Database Record (c) 2016 APA, all rights reserved).
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Lindenburg, Laurens H; Malisauskas, Mantas; Sips, Tari; van Oppen, Lisanne; Wijnands, Sjors P W; van de Graaf, Stan F J; Merkx, Maarten
2014-10-14
The introduction of weak, hydrophobic interactions between fluorescent protein domains (FPs) can substantially increase the dynamic range (DR) of Förster resonance energy transfer (FRET)-based sensor systems. Here we report a comprehensive thermodynamic characterization of the stability of a range of self-associating FRET pairs. A new method is introduced that allows direct quantification of the stability of weak FP interactions by monitoring intramolecular complex formation as a function of urea concentration. The commonly used S208F mutation stabilized intramolecular FP complex formation by 2.0 kCal/mol when studied in an enhanced cyan FP (ECFP)-linker-enhanced yellow FP (EYFP) fusion protein, whereas a significantly weaker interaction was observed for the homologous Cerulean/Citrine FRET pair (ΔG0(o-c) = 0.62 kCal/mol). The latter effect could be attributed to two mutations in Cerulean (Y145A and H148D) that destabilize complex formation with Citrine. Systematic analysis of the contribution of residues 125 and 127 at the dimerization interface in mOrange.linker.mCherry fusion proteins yielded a toolbox of new mOrange-mCherry combinations that allowed tuning of their intramolecular interaction from very weak (ΔG0(o-c) = .0.39 kCal/mol) to relatively stable (ΔG0(o-c) = 2.2 kCal/mol). The effects of these mutations were also studied by monitoring homodimerization of mCherry variants using fluorescence anisotropy. These mutations affected intramolecular and intermolecular domain interactions similarly, although FP interactions were found to be stronger in the latter. The knowledge thus obtained allowed successful construction of a red-shifted variant of the bile acid FRET sensor BAS-1 by replacement of the self-associating Cerulean-Citrine pair by mOrange.mCherry variants with a similar intramolecular affinity. Our findings thus allow a better understanding of the subtle but important role of intramolecular domain interactions in current FRET sensors and help guide the construction of new sensors using modular design strategies.
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Craig Adair; David B. McKeever
2009-01-01
The construction of new single family, multifamily, and manufactured housing is an important market for wood products in both the United States and Canada. Annual wood products consumption is dependent on many factors, including the number of new units started, the size of units started, architectural characteristics, and consumer preferences. In 2006, about 39 percent...
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COMPETING IN THE SOCIAL BATTLESPACE: INFLUENCING THE THREE DOMAINS
2017-06-01
Legacy (Knopf Doubleday Publishing Group, 2009), 33. 39 Norman Polmar and Kenneth J. Moore, Cold War Submarines: The Design and Construction of U.S...and shot Brown six times in the back, killing him. Michael Brown would lay four hours on the pavement as additional police officers and...Cornell University Press. Polmar, Norman, and Kenneth J. Moore. Cold War Submarines: The Design and Construction of U.S. and Soviet Submarines
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39 CFR 776.9 - Review procedures.
Code of Federal Regulations, 2012 CFR
2012-07-01
... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending site(s) could require construction in a wetland, public notice must be provided. (b) Finding of no practicable...
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39 CFR 776.9 - Review procedures.
Code of Federal Regulations, 2010 CFR
2010-07-01
... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending site(s) could require construction in a wetland, public notice must be provided. (b) Finding of no practicable...
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39 CFR 776.9 - Review procedures.
Code of Federal Regulations, 2013 CFR
2013-07-01
... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending site(s) could require construction in a wetland, public notice must be provided. (b) Finding of no practicable...
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39 CFR 776.9 - Review procedures.
Code of Federal Regulations, 2011 CFR
2011-07-01
... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending site(s) could require construction in a wetland, public notice must be provided. (b) Finding of no practicable...
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39 CFR 776.9 - Review procedures.
Code of Federal Regulations, 2014 CFR
2014-07-01
... Service UNITED STATES POSTAL SERVICE ENVIRONMENTAL REGULATIONS FLOODPLAIN AND WETLAND PROCEDURES Wetlands Protection § 776.9 Review procedures. (a) Early public notice. If a facility action at the contending site(s) could require construction in a wetland, public notice must be provided. (b) Finding of no practicable...
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2004-03-26
CAPE CANAVERAL, Fla. -- This aerial photo shows the expanse of the Launch Complex 39 Area, bordered at the top by the Atlantic and a cloud-filled sky. At center right, towering above the surrounding sites, is the Vehicle Assembly Building. To the left is the Orbiter Processing Facility's Bay 3. In the foreground are OPF Bays 1 and 2. The two-lane crawlerway stretches from the VAB toward the coast, site of Launch Pad 39A, closest, and Launch Pad 39B, far left. Between the VAB and the ocean sprawl the Banana Creek and the Banana River. Photo credit: NASA
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Representation of complex probabilities and complex Gibbs sampling
NASA Astrophysics Data System (ADS)
Salcedo, Lorenzo Luis
2018-03-01
Complex weights appear in Physics which are beyond a straightforward importance sampling treatment, as required in Monte Carlo calculations. This is the wellknown sign problem. The complex Langevin approach amounts to effectively construct a positive distribution on the complexified manifold reproducing the expectation values of the observables through their analytical extension. Here we discuss the direct construction of such positive distributions paying attention to their localization on the complexified manifold. Explicit localized representations are obtained for complex probabilities defined on Abelian and non Abelian groups. The viability and performance of a complex version of the heat bath method, based on such representations, is analyzed.
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Development and validation of a mass casualty conceptual model.
Culley, Joan M; Effken, Judith A
2010-03-01
To develop and validate a conceptual model that provides a framework for the development and evaluation of information systems for mass casualty events. The model was designed based on extant literature and existing theoretical models. A purposeful sample of 18 experts validated the model. Open-ended questions, as well as a 7-point Likert scale, were used to measure expert consensus on the importance of each construct and its relationship in the model and the usefulness of the model to future research. Computer-mediated applications were used to facilitate a modified Delphi technique through which a panel of experts provided validation for the conceptual model. Rounds of questions continued until consensus was reached, as measured by an interquartile range (no more than 1 scale point for each item); stability (change in the distribution of responses less than 15% between rounds); and percent agreement (70% or greater) for indicator questions. Two rounds of the Delphi process were needed to satisfy the criteria for consensus or stability related to the constructs, relationships, and indicators in the model. The panel reached consensus or sufficient stability to retain all 10 constructs, 9 relationships, and 39 of 44 indicators. Experts viewed the model as useful (mean of 5.3 on a 7-point scale). Validation of the model provides the first step in understanding the context in which mass casualty events take place and identifying variables that impact outcomes of care. This study provides a foundation for understanding the complexity of mass casualty care, the roles that nurses play in mass casualty events, and factors that must be considered in designing and evaluating information-communication systems to support effective triage under these conditions.
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A Principal Component Analysis of 39 Scientific Impact Measures
Bollen, Johan; Van de Sompel, Herbert
2009-01-01
Background The impact of scientific publications has traditionally been expressed in terms of citation counts. However, scientific activity has moved online over the past decade. To better capture scientific impact in the digital era, a variety of new impact measures has been proposed on the basis of social network analysis and usage log data. Here we investigate how these new measures relate to each other, and how accurately and completely they express scientific impact. Methodology We performed a principal component analysis of the rankings produced by 39 existing and proposed measures of scholarly impact that were calculated on the basis of both citation and usage log data. Conclusions Our results indicate that the notion of scientific impact is a multi-dimensional construct that can not be adequately measured by any single indicator, although some measures are more suitable than others. The commonly used citation Impact Factor is not positioned at the core of this construct, but at its periphery, and should thus be used with caution. PMID:19562078
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2015-01-01
Immunoassays have been translated into microfluidic device formats, but significant challenges relating to upstream sample processing still limit their applications. Here, stimuli-responsive polymer–antibody conjugates are utilized in a microfluidic immunoassay to enable rapid biomarker purification and enrichment as well as sensitive detection. The conjugates were constructed by covalently grafting poly(N-isopropylacrylamide) (PNIPAAm), a thermally responsive polymer, to the lysine residues of anti-prostate specific antigen (PSA) Immunoglobulin G (IgG) using carbodiimide chemistry via the polymer end-carboxylate. The antibody-PNIPAAm (capture) conjugates and antibody-alkaline phosphatase (detection) conjugates formed sandwich immunocomplexes via PSA binding in 50% human plasma. The complexes were loaded into a recirculating poly(dimethylsiloxane) microreactor, equipped with micropumps and transverse flow features, for subsequent separation, enrichment, and quantification. The immunocomplexes were captured by heating the solution to 39 °C, mixed over the transverse features for 2 min, and washed with warm buffer. In one approach, the assay utilized immunocomplex solution that was contained in an 80 nL microreactor, which was loaded with solution at room temperature and subsequently heated to 39 °C. The assay took 25 min and resulted in 37 pM PSA limit of detection (LOD), which is comparable to a plate ELISA employing the same antibody pair. In another approach, the microreactor was preheated to 39 °C, and immunocomplex solution was flowed through the reactor, mixed, and washed. When the specimen volume was increased to 7.5 μL by repeating the capture process three times, the higher specimen volume led to immunocomplex enrichment within the microreactor. The resulting assay LOD was 0.5 pM, which is 2 orders of magnitude lower than the plate ELISA. Both approaches generate antigen specific signal over a clinically significant range. The sample processing capabilities and subsequent utility in a biomarker assay demonstrate the opportunity for stimuli-responsive polymer–protein conjugates in novel diagnostic technologies. PMID:25405605
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1987-01-01
AND HYDROLOGIC DATA FOR OBSERVATION WELLS IN THE REELFOOT LAKE AREA, TENNESSEE AND KENTUCKY ($3 1 .cz Prepared in cooperation with the...Observation Wells in The Reelfoot Lake Area, Tennessee and Kentucky 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d...Prescribed by ANSI Std Z39-18 CONSTRUCTION, GEOLOGIC, AND HYDROLOGIC DATA FOR OBSERVATION WELLS IN THE REELFOOT LAKE AREA, TENNESSEE AND KENTUCKY Michael
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Self-assembled nanoscale DNA-porphyrin complex for artificial light harvesting.
Woller, Jakob G; Hannestad, Jonas K; Albinsson, Bo
2013-02-20
Mimicking green plants' and bacteria's extraordinary ability to absorb a vast number of photons and harness their energy is a longstanding goal in artificial photosynthesis. Resonance energy transfer among donor dyes has been shown to play a crucial role on the overall transfer of energy in the natural systems. Here, we present artificial, self-assembled, light-harvesting complexes consisting of DNA scaffolds, intercalated YO-PRO-1 (YO) donor dyes and a porphyrin acceptor anchored to a lipid bilayer, conceptually mimicking the natural light-harvesting systems. A model system consisting of 39-mer duplex DNA in a linear wire configuration with the porphyrin attached in the middle of the wire is primarily investigated. Utilizing intercalated donor fluorophores to sensitize the excitation of the porphyrin acceptor, we obtain an effective absorption coefficient 12 times larger than for direct excitation of the porphyrin. On the basis of steady-state and time-resolved emission measurements and Markov chain simulations, we show that YO-to-YO resonance energy transfer substantially contributes to the overall flow of energy to the porphyrin. This increase is explained through energy migration along the wire allowing the excited state energy to transfer to positions closer to the porphyrin. The versatility of DNA as a structural material is demonstrated through the construction of a more complex, hexagonal, light-harvesting scaffold yielding further increase in the effective absorption coefficient. Our results show that, by using DNA as a scaffold, we are able to arrange chromophores on a nanometer scale and in this way facilitate the assembly of efficient light-harvesting systems.
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2014-12-01
MA January 2015 3 There are no existing underground stormwater drains in the area of the new Vandenberg Gate Complex. The addition of... stormwater management systems that utilize the pervious landscape, vegetative filtration, sediment removal, infiltration via bioswales, deep sump...Airmen Dormitory construction, a base-wide stormwater standard requires redevelopment projects to reduce stormwater rate and volume by 10% over the
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2007-09-01
Adaptive Systems............................................. 64 3.9 Connectivity and Communication in Complex Adaptive Systems...450 3.10.6 Human Factors: Perception, Comprehension, Communication and Collaboration...288 B.9 Catastrophe, Conflict, Crisis
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Methods of erection of high-rise buildings
NASA Astrophysics Data System (ADS)
Cherednichenko, Nadezhda; Oleinik, Pavel
2018-03-01
The article contains the factors determining the choice of methods for organizing the construction and production of construction and installation work for the construction of high-rise buildings. There are also indicated specific features of their underground parts, characterized by powerful slab-pile foundations, large volumes of earthworks, reinforced bases and foundations for assembly cranes. The work cycle is considered when using reinforced concrete, steel and combined skeletons of high-rise buildings; the areas of application of flow, separate and complex methods are being disclosed. The main conditions for the erection of high-rise buildings and their components are singled out: the choice of formwork systems, delivery and lifting of concrete mixes, installation of reinforcement, the formation of lifting and transporting and auxiliary equipment. The article prescribes the reserves of reduction in the duration of construction due to the creation of: complex mechanized technologies for the efficient construction of foundations in various soil conditions, including in the heaving, swelling, hindered, subsidence, bulk, water-saturated forms; complex mechanized technologies for the erection of monolithic reinforced concrete structures, taking into account the winter conditions of production and the use of mobile concrete-laying complexes and new generation machines; modular formwork systems, distinguished by their versatility, ease, simplicity in operation suitable for complex high-rise construction; more perfect methodology and the development of a set of progressive organizational and technological solutions that ensure a rational relationship between the processes of production and their maximum overlap in time and space.
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Examining the Challenging Hindrances facing in the Construction Projects: South India’s Perspective
NASA Astrophysics Data System (ADS)
Subramanyam, K.; Haridharan, M. K.
2017-07-01
Developing countries like India require a huge infrastructure to facilitate needs of the people. Construction industry provides several opportunities to the individuals. Construction manager work is to supervise and organize the construction activities in construction projects. Now a day construction manager facing challenges. This paper aimed to study the challenges facing by the construction manager in the perception of construction professionals. 39 variables were taken from the literature review which found to be severe impact on construction managers’ performance. Construction manager, project manager and site engineers are the respondents for this survey. Using SPSS, regression analysis was done and recognized significant challenges. These challenges were classified into 5 domains. In management challenges, resource availability and allocation, risks and uncertainties existing in the project onsite, top management support and cost constraints are the most significant variables. In skills requirement of a construction manager challenges, technical skills required to learn and adapt new technology in the project, decision making and planning according to the situation in site are the most significant variables. In performance challenges, implementation of tasks according to the plan is the important variable whereas in onsite challenges, manage project risks, develop project policies and procedures are the most important.
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Xu, Jiancong; Crowley, Michael F; Smith, Jeremy C
2009-01-01
The organization and assembly of the cellulosome, an extracellular multienzyme complex produced by anaerobic bacteria, is mediated by the high-affinity interaction of cohesin domains from scaffolding proteins with dockerins of cellulosomal enzymes. We have performed molecular dynamics simulations and free energy calculations on both the wild type (WT) and D39N mutant of the C. thermocellum Type I cohesin-dockerin complex in aqueous solution. The D39N mutation has been experimentally demonstrated to disrupt cohesin-dockerin binding. The present MD simulations indicate that the substitution triggers significant protein flexibility and causes a major change of the hydrogen-bonding network in the recognition strips—the conserved loop regions previously proposed to be involved in binding—through electrostatic and salt-bridge interactions between β-strands 3 and 5 of the cohesin and α-helix 3 of the dockerin. The mutation-induced subtle disturbance in the local hydrogen-bond network is accompanied by conformational rearrangements of the protein side chains and bound water molecules. Additional free energy perturbation calculations of the D39N mutation provide differences in the cohesin-dockerin binding energy, thus offering a direct, quantitative comparison with experiments. The underlying molecular mechanism of cohesin-dockerin complexation is further investigated through the free energy profile, that is, potential of mean force (PMF) calculations of WT cohesin-dockerin complex. The PMF shows a high-free energy barrier against the dissociation and reveals a stepwise pattern involving both the central β-sheet interface and its adjacent solvent-exposed loop/turn regions clustered at both ends of the β-barrel structure. PMID:19384997
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Trudeau, Natacha; Sutton, Ann; Dagenais, Emmanuelle; de Broeck, Sophie; Morford, Jill
2007-10-01
This study investigated the impact of syntactic complexity and task demands on construction of utterances using picture communication symbols by participants from 3 age groups with no communication disorders. Participants were 30 children (7;0 [years;months] to 8;11), 30 teenagers (12;0 to 13;11), and 30 adults (18 years and above). All participants constructed graphic symbol utterances to describe photographs presented with spoken French stimuli. Stimuli included simple and complex (object relative and subject relative) utterances describing the photographs, which were presented either 1 at a time (neutral condition) or in an array of 4 (contrast condition). Simple utterances lead to more uniform response patterns than complex utterances. Among complex utterances, subject relative sentences appeared more difficult to convey. Increasing the need for message clarity (i.e., contrast condition) elicited changes in the production of graphic symbol sequences for complex propositions. The effects of syntactic complexity and task demands were more pronounced for children. Graphic symbol utterance construction appears to involve more than simply transferring spoken language skills. One possible explanation is that this type of task requires higher levels of metalinguistic ability. Clinical implications and directions for further research are discussed.
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Hong, Jun; Wang, Wei; Huang, Kun; Yang, Wei-Yun; Zhao, Ying-Xue; Xiao, Bao-Lin; Gao, Yun-Fei; Moosavi-Movahedi, Zainab; Ghourchian, Hedayatollah; Moosavi-Movahedi, Ali Akbar
2012-01-01
A nano-cluster with highly efficient peroxide activity was constructed based on nafion (NF) and cytochrome c (Cyt c). UV-Vis spectrometry and transmission electron microscopy (TEM) methods were utilized for characterization of the nano-structured enzyme or artificial peroxidase (AP). The nano-cluster was composed of a Chain-Ball structure, with an average ball size of about 40 nm. The Michaelis-Menten (K(m)) and catalytic rate (k(cat)) constants of the AP were determined to be 2.5 ± 0.4 µM and 0.069 ± 0.001 s(-1), respectively, in 50 mM PBS at pH 7.0. The catalytic efficiency of the AP was evaluated to be 0.028 ± 0.005 µM(-1) s(-1), which was 39 ± 5% as efficient as the native horseradish peroxidase (HRP). The AP was also immobilized on a functional multi-wall carbon nanotube (MWNCTs)-gold colloid nanoparticles (AuNPs) nano-complex modified glassy carbon (GC) electrode. The cyclic voltammetry of AP on the nano complex modified GC electrode showed a pair of well-defined redox peaks with a formal potential (E°') of -45 ± 2 mV (vs. Ag/AgCl) at a scan rate of 0.05 V/s. The heterogeneous electron transfer rate constant (k(s)) was evaluated to be 0.65 s(-1). The surface concentration of electroactive AP on GC electrode (Γ) was 7 × 10(-10) mol cm(-2). The apparent Michaelis-Menten constant (K(m)(app)) was 0.23 nM.
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Choi, Kimyung; Shim, Joohyun; Ko, Nayoung; Eom, Heejong; Kim, Jiho; Lee, Jeong-Woong; Jin, Dong-Il; Kim, Hyunil
2017-04-01
Production of transgenic pigs for use as xenotransplant donors is a solution to the severe shortage of human organs for transplantation. The first barrier to successful xenotransplantation is hyperacute rejection, a rapid, massive humoral immune response directed against the pig carbohydrate GGTA1 epitope. Platelet activation, adherence, and clumping, all major features of thrombotic microangiopathy, are inevitable results of immune-mediated transplant rejection. Human CD39 rapidly hydrolyzes ATP and ADP to AMP; AMP is hydrolyzed by ecto-5'-nucleotidase (CD73) to adenosine, an anti-thrombotic and cardiovascular protective mediator. In this study, we developed a vector-based strategy for ablation of GGTA1 function and concurrent expression of human CD39 (hCD39). An hCD39 expression cassette was constructed to target exon 4 of GGTA1. We established heterozygous GGTA1 knock-out cell lines expressing hCD39 from pig ear fibroblasts for somatic cell nuclear transfer (SCNT). We also described production of heterozygous GGTA1 knock-out piglets expressing hCD39 and analyzed expression and function of the transgene. Human CD39 was expressed in heart, kidney and aorta. Human CD39 knock-in heterozygous ear fibroblast from transgenic cloned pigs, but not in non-transgenic pig's cells. Expression of GGTA1 gene was lower in the knock-in heterozygous ear fibroblast from transgenic pigs compared to the non-transgenic pig's cell. The peripheral blood mononuclear cells (PBMC) from the transgenic pigs were more resistant to lysis by pooled complement-preserved normal human serum than that from wild type (WT) pig. Accordingly, GGTA1 mutated piglets expressing hCD39 will provide a new organ source for xenotransplantation research.
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Presentation Media, Information Complexity, and Learning Outcomes
ERIC Educational Resources Information Center
Andres, Hayward P.; Petersen, Candice
2002-01-01
Cognitive processing limitations restrict the number of complex information items held and processed in human working memory. To overcome such limitations, a verbal working memory channel is used to construct an if-then proposition representation of facts and a visual working memory channel is used to construct a visual imagery of geometric…
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Assessment and monitoring practices of Australian fitness professionals.
Bennie, Jason A; Wiesner, Glen H; van Uffelen, Jannique G Z; Harvey, Jack T; Craike, Melinda J; Biddle, Stuart J H
2018-04-01
Assessment and monitoring of client health and fitness is a key part of fitness professionals' practices. However, little is known about prevalence of this practice. This study describes the assessment/monitoring practices of a large sample of Australian fitness professionals. Cross-sectional. In 2014, 1206 fitness professionals completed an online survey. Respondents reported their frequency (4 point-scale: [1] 'never' to [4] 'always') of assessment/monitoring of eight health and fitness constructs (e.g. body composition, aerobic fitness). This was classified as: (i) 'high' ('always' assessing/monitoring ≥5 constructs); (ii) 'medium' (1-4 constructs); (iii) 'low' (0 constructs). Classifications are reported by demographic and fitness industry characteristics. The odds of being classified as a 'high assessor/monitor' according to social ecological correlates were examined using a multiple-factor logistic regression model. Mean age of respondents was 39.3 (±11.6) years and 71.6% were female. A total of 15.8% (95% CI: 13.7%-17.9%) were classified as a 'high' assessor/monitor. Constructs with the largest proportion of being 'always' assessed were body composition (47.7%; 95% CI: 45.0%-50.1%) and aerobic fitness (42.5%; 95% CI: 39.6%-45.3%). Those with the lowest proportion of being 'always' assessed were balance (24.0%; 95% CI: 24.7%-26.5%) and mental health (20.2%; 95% CI: 18.1%-29.6%). A perceived lack of client interest and fitness professionals not considering assessing their responsibility were associated with lower odds of being classified as a 'high assessor/monitor'. Most fitness professionals do not routinely assess/monitor client fitness and health. Key factors limiting client health assessment and monitoring include a perceived lack of client interest and professionals not considering this their role. Copyright © 2017. Published by Elsevier Ltd.
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STS-28 Columbia, OV-102, crewmembers leave KSC O&C Bldg en route to LC Pad 39
1989-08-08
STS028-S-002 (8 Aug 1989) --- The five astronaut crewmembers for STS-28 leave the Operations and Checkout (O&C) Building to board a transfer van en route to Launch Complex 39 for a date with Columbia. Left to right are Astronauts Mark N. Brown, James C. Adamson, David C. Leestma, Richard N. Richards and Brewster H. Shaw Jr.
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2009-01-26
CAPE CANAVERAL, Fla. – On Launch Pad 39B at NASA's Kennedy Space Center in Florida, a crane places a 100-foot fiberglass lightning mast on top of the 500-foot tower. The tower is one of three being constructed for the Constellation Program and Ares/Orion launches. Another tower is seen at right. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009. Photo credit: NASA/Jack Pfaller
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STS-29 Discovery, Orbiter Vehicle (OV) 103, roll out to KSC LC Pad 39B
NASA Technical Reports Server (NTRS)
1989-01-01
In the early morning hours, STS-29 Discovery, Orbiter Vehicle (OV) 103, mated to the external tank (ET) and solid rocket boosters (SRBs) is rolled out to Kennedy Space Center (KSC) Launch Complex (LC) Pad 39B atop the mobile launcher platform. Trees, shrubs, and a light mist surround the mobile launcher platform as it makes its way to LC Pad 39B. OV-103 will fly on Mission STS-29 scheduled for launch in mid-March. View provided by KSC with alternate KSC number KSC-89PC-50.
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NASA Technical Reports Server (NTRS)
Wilson, Timmy R.; Beech, Geoffrey; Johnston, Ian
2009-01-01
The NESC Assessment Team reviewed a computer simulation of the LC-39 External Tank (ET) GH2 Vent Umbilical system developed by United Space Alliance (USA) for the Space Shuttle Program (SSP) and designated KSC Analytical Tool ID 451 (KSC AT-451). The team verified that the vent arm kinematics were correctly modeled, but noted that there were relevant system sensitivities. Also, the structural stiffness used in the math model varied somewhat from the analytic calculations. Results of the NESC assessment were communicated to the model developers.
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Jealousy Graphs: Structure and Complexity of Decentralized Stable Matching
2013-01-01
REPORT Jealousy Graphs: Structure and Complexity of Decentralized Stable Matching 14. ABSTRACT 16. SECURITY CLASSIFICATION OF: The stable matching...Franceschetti 858-822-2284 3. DATES COVERED (From - To) Standard Form 298 (Rev 8/98) Prescribed by ANSI Std. Z39.18 - Jealousy Graphs: Structure and...market. Using this structure, we are able to provide a ner analysis of the complexity of a subclass of decentralized matching markets. Jealousy
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2009-06-01
AUTOMATED GEOSPATIAL TOOLS : AGILITY IN COMPLEX PLANNING Primary Topic: Track 5 – Experimentation and Analysis Walter A. Powell [STUDENT] - GMU...TITLE AND SUBTITLE Results of an Experimental Exploration of Advanced Automated Geospatial Tools : Agility in Complex Planning 5a. CONTRACT NUMBER...Std Z39-18 Abstract Typically, the development of tools and systems for the military is requirement driven; systems are developed to meet
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STS-65 Columbia, OV-102, lifts off from KSC Launch Complex (LC) Pad 39A
NASA Technical Reports Server (NTRS)
1994-01-01
Columbia, Orbiter Vehicle (OV) 102, atop its external tank (ET) rises above the Kennedy Space Center (KSC) Launch Complex (LC) Pad 39A after liftoff at 12:43 pm Eastern Daylight Time (EDT). OV-102 starboard side and one of the two solid rocket boosters (SRBs) are visible in this launch view. The retracted rotating service structure (RSS) is nearly covered in the shuttle's exhaust at the left as OV-102 clears the fixed service structure (FSS) tower. The space shuttle main engines produce a diamond shock effect. Once in orbit, STS-65's six NASA astronauts and a Japanese Payload Specialist will begin two weeks of experimentation in support of the second International Microgravity Laboratory (IML-2) mission.
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Genomics dataset on unclassified published organism (patent US 7547531).
Khan Shawan, Mohammad Mahfuz Ali; Hasan, Md Ashraful; Hossain, Md Mozammel; Hasan, Md Mahmudul; Parvin, Afroza; Akter, Salina; Uddin, Kazi Rasel; Banik, Subrata; Morshed, Mahbubul; Rahman, Md Nazibur; Rahman, S M Badier
2016-12-01
Nucleotide (DNA) sequence analysis provides important clues regarding the characteristics and taxonomic position of an organism. With the intention that, DNA sequence analysis is very crucial to learn about hierarchical classification of that particular organism. This dataset (patent US 7547531) is chosen to simplify all the complex raw data buried in undisclosed DNA sequences which help to open doors for new collaborations. In this data, a total of 48 unidentified DNA sequences from patent US 7547531 were selected and their complete sequences were retrieved from NCBI BioSample database. Quick response (QR) code of those DNA sequences was constructed by DNA BarID tool. QR code is useful for the identification and comparison of isolates with other organisms. AT/GC content of the DNA sequences was determined using ENDMEMO GC Content Calculator, which indicates their stability at different temperature. The highest GC content was observed in GP445188 (62.5%) which was followed by GP445198 (61.8%) and GP445189 (59.44%), while lowest was in GP445178 (24.39%). In addition, New England BioLabs (NEB) database was used to identify cleavage code indicating the 5, 3 and blunt end and enzyme code indicating the methylation site of the DNA sequences was also shown. These data will be helpful for the construction of the organisms' hierarchical classification, determination of their phylogenetic and taxonomic position and revelation of their molecular characteristics.
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Thermal Imaging for Inspection of Large Cryogenic Tanks
NASA Technical Reports Server (NTRS)
Arens, Ellen
2012-01-01
The end of the Shuttle Program provides an opportunity to evaluate and possibly refurbish launch support infrastructure at the Kennedy Space Center in support of future launch vehicles. One major infrastructure element needing attention is the cryogenic fuel and oxidizer system and specifically the cryogenic fuel ground storage tanks located at Launch Complex 39. These tanks were constructed in 1965 and served both the Apollo and Shuttle Programs and will be used to support future launch programs. However, they have received only external inspection and minimal refurbishment over the years as there were no operational issues that warranted the significant time and schedule disruption required to drain and refurbish the tanks while the launch programs were ongoing. Now, during the break between programs, the health of the tanks is being evaluated and refurbishment is being performed as necessary to maintain their fitness for future launch programs. Thermography was used as one part of the inspection and analysis of the tanks. This paper will describe the conclusions derived from the thermal images to evaluate anomalous regions in the tanks, confirm structural integrity of components within the annular region, and evaluate the effectiveness of thermal imaging to detect large insulation voids in tanks prior to filling with cryogenic fluid. The use of thermal imaging as a tool to inspect unfilled tanks will be important if the construction of additional storage tanks is required to fuel new launch vehicles.
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Evaluation of various hot mix asphalt pavement thicknesses over rubblized concrete pavement.
DOT National Transportation Integrated Search
2011-07-01
In 1999, the Wisconsin DOT constructed two test sections as part of a rubblized PCC pavement project on I-39 to evaluate whether : increased HMA thickness could extend the pavement system's service life. Design thicknesses of the control and test sec...
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19. CONSTRUCTION PROGRESS PHOTO SHOWING (TYPICALLY COMPLEX) WASTE HOLDING CELL ...
19. CONSTRUCTION PROGRESS PHOTO SHOWING (TYPICALLY COMPLEX) WASTE HOLDING CELL PIPING. INEEL PHOTO NUMBER NRTS-59-3212. - Idaho National Engineering Laboratory, Old Waste Calcining Facility, Scoville, Butte County, ID
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DOT National Transportation Integrated Search
2004-01-01
Accelerated Construction Technology Transfer (ACTT) is a strategic process that uses various innovative techniques, strategies, and technologies to minimize actual construction time, while enhancing quality and safety on today's large, complex multip...
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SpaceX CRS-10 Post Launch News Conference
2017-02-19
In the Press Site auditorium of NASA's Kennedy Space Center in Florida, Jessica Jensen, Dragon mission manager for SpaceX, speaks to the news media at a post-launch news conference following the liftoff of SpaceX CRS-10, a commercial resupply services mission to the International Space Station. SpaceX CRS-10 lifted off atop a Falcon 9 rocket from Kennedy's Launch Complex 39A at 9:39 a.m. EST.
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SpaceX CRS-10 Post Launch News Conference
2017-02-19
In the Press Site auditorium of NASA's Kennedy Space Center in Florida, William Spetch, deputy manager of the International Space Station Transportation Office, speaks to the news media at a post-launch news conference following the liftoff of SpaceX CRS-10, a commercial resupply services mission to the International Space Station. SpaceX CRS-10 lifted off atop a Falcon 9 rocket from Kennedy's Launch Complex 39A at 9:39 a.m. EST.
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Report of CEC Study Committee on Construction Management.
ERIC Educational Resources Information Center
Consulting Engineers Council of the U.S., Washington, DC.
Changing times place new demands on those involved in the implementation of construction projects. Within a relatively few years, the size and complexity of projects has grown substantially. Environmental and other public and social considerations are increasingly significant. With growing complexity, the requirements for effective project…
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NASA Astrophysics Data System (ADS)
Jurčo, Branislav
2012-12-01
Let g be a simplicial Lie algebra with Moore complex Ng of length k. Let G be the simplicial Lie group integrating g, such that each Gn is simply connected. We use the 1-jet of the classifying space W¯ G to construct, starting from g, a Lie k-algebra L. The so constructed Lie k-algebra L is actually a differential graded Lie algebra. The differential and the brackets are explicitly described in terms (of a part) of the corresponding k-hypercrossed complex structure of Ng. The result can be seen as a geometric interpretation of Quillen's (purely algebraic) construction of the adjunction between simplicial Lie algebras and dg-Lie algebras.
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ERIC Educational Resources Information Center
Révész, Andrea; Sachs, Rebecca; Hama, Mika
2014-01-01
This investigation examined two techniques that may help learners focus on second language (L2) constructions when recasts are provided during meaning-based communicative activities: altering the cognitive complexity of tasks and manipulating the input frequency distributions of target constructions. We first independently assessed the validity of…
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Effects of organizational complexity and resources on construction site risk.
Forteza, Francisco J; Carretero-Gómez, Jose M; Sesé, Albert
2017-09-01
Our research is aimed at studying the relationship between risk level and organizational complexity and resources on constructions sites. Our general hypothesis is that site complexity increases risk, whereas more resources of the structure decrease risk. A Structural Equation Model (SEM) approach was adopted to validate our theoretical model. To develop our study, 957 building sites in Spain were visited and assessed in 2003-2009. All needed data were obtained using a specific tool developed by the authors to assess site risk, structure and resources (Construction Sites Risk Assessment Tool, or CONSRAT). This tool operationalizes the variables to fit our model, specifically, via a site risk index (SRI) and 10 organizational variables. Our random sample is composed largely of small building sites with general high levels of risk, moderate complexity, and low resources on site. The model obtained adequate fit, and results showed empirical evidence that the factors of complexity and resources can be considered predictors of site risk level. Consequently, these results can help companies, managers of construction and regulators to identify which organizational aspects should be improved to prevent risks on sites and consequently accidents. Copyright © 2017 National Safety Council and Elsevier Ltd. All rights reserved.
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A Review of Battle Damage Prediction and Vulnerability Reduction Methods
2010-10-01
monolithic constructions. Bahei-El-Din and Dvorak [38] showed that the use of a polyurethane or polyurea interlayer used in a sandwich plate in...sandwich plates reinforced with polyurethane/ polyurea interlayers under blast loads. Journal of Sandwich Structures and Materials 9 (3) 261–281. 39
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STS-98 Destiny in Atlantis's payload bay
NASA Technical Reports Server (NTRS)
2001-01-01
KENNEDY SPACE CENTER, Fla. -- At Launch Pad 39A, the U.S. Laboratory Destiny waits in Atlantis'''s payload bay for closure of the payload bay doors. Destiny, a key element in the construction of the International Space Station, is 28 feet long and weighs 16 tons. This research and command-and-control center is the most sophisticated and versatile space laboratory ever built. It will ultimately house a total of 23 experiment racks for crew support and scientific research. Destiny will be launched Feb. 7 on STS-98, the seventh construction flight to the ISS.
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Variable-Delay Polarization Modulators for Cryogenic Millimeter-Wave Applications
NASA Technical Reports Server (NTRS)
Chuss, D. T.; Eimer, J. R.; Fixsen, D. J.; Hinderks, J.; Kogut, A. J.; Lazear, J.; Mirel, P.; Switzer, E.; Voellmer, G. M.; Wollack, E. J..
2014-01-01
We describe the design, construction, and initial validation of the variable-delay polarization modulator (VPM) designed for the PIPER cosmic microwave background polarimeter. The VPM modulates between linear and circular polarization by introducing a variable phase delay between orthogonal linear polarizations. Each VPM has a diameter of 39 cm and is engineered to operate in a cryogenic environment (1.5 K). We describe the mechanical design and performance of the kinematic double-blade flexure and drive mechanism along with the construction of the high precision wire grid polarizers.
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2000-10-31
KENNEDY SPACE CENTER, Fla. -- Space Shuttle Endeavour inches its way to Launch Pad 39B via the crawlerway that leads from the Vehicle Assembly Building. The Shuttle is on the Mobile Launcher Platform (MLP) which is atop the crawler-transporter, moving on four double-tracked crawlers. The maximum speed of the loaded transporter is 1 mph. To the left and right of the Space Shuttle can be seen both launch pads, 39B and 39A respectively. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections
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2000-10-31
KENNEDY SPACE CENTER, Fla. -- Space Shuttle Endeavour inches its way to Launch Pad 39B via the crawlerway that leads from the Vehicle Assembly Building. The Shuttle is on the Mobile Launcher Platform (MLP) which is atop the crawler-transporter, moving on four double-tracked crawlers. The maximum speed of the loaded transporter is 1 mph. To the left and right of the Space Shuttle can be seen both launch pads, 39B and 39A respectively. Endeavour is scheduled to be launched Nov. 30 at 10:01 p.m. EST on mission STS-97, the sixth construction flight to the International Space Station. Its payload includes the P6 Integrated Truss Structure and a photovoltaic (PV) module, with giant solar arrays that will provide power to the Station. The mission includes two spacewalks to complete the solar array connections
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Relationship between clock and star drawing and the degree of hepatic encephalopathy.
Edwin, Natasha; Peter, John Victor; John, George; Eapen, C E; Graham, Petra L
2011-09-01
PURPOSE OF THE STUDY Current hepatic encephalopathy grading tools are limited because of complexity or subjectivity. The degree of constructional apraxia could serve as a simple, objective and reproducible tool to grade encephalopathy. STUDY DESIGN In this cross-sectional study of patients with chronic liver disease, the degree of constructional apraxia was judged by their ability to copy a star and clock face and compared with conventional encephalopathy grading by the West Haven Criteria (WHC) and the Porto Systemic Encephalopathy Index (PSEI). Three blinded observers independently graded the figures. Sensitivity, specificity and positive predictive value (PPV) of clock and star scores (score 0 implying no encephalopathy and >0 hepatic encephalopathy) were assessed against conventional scoring systems (WHC grade >0 or PSEI ≥0.33 indicating encephalopathy). Mosaic and box plots were generated to assess if the degree of constructional apraxia correlated with the severity of encephalopathy. RESULTS 71 patients were studied between October 2008 and July 2009; 11 (15.4%) had WHC grade 0, 32 (45%) grade 1, and 28 (39.4%) grades 2 and 3 encephalopathy. The sensitivity, specificity and PPV of the clock drawing for the diagnosis of encephalopathy was 85%, 80%, and 96%, respectively, and 77%, 70%, and 94%, respectively, for the star drawing. Box plots and intervals on mean PSEI showed an increasing relationship between clock/star scores and PSEI. There was substantial agreement between WHC and clock (weighted κ 0.61) and star scores (weighted κ 0.71). Inter-observer reliability was at least 0.70 for star and at least 0.79 for the clock score. CONCLUSION Clock and star drawing may serve as reproducible, inexpensive bedside tools for diagnosing and grading the severity of hepatic encephalopathy.
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Bazot, Quentin; Paschos, Kostas; Allday, Martin J
2018-04-01
Epstein-Barr virus (EBV) establishes latent infection in human B cells and is associated with a wide range of cancers. The EBV nuclear antigen 3 (EBNA3) family proteins are critical for B cell transformation and function as transcriptional regulators. It is well established that EBNA3A and EBNA3C cooperate in the regulation of cellular genes. Here, we demonstrate that the gene STK39 is repressed only by EBNA3A. This is the first example of a gene regulated only by EBNA3A in EBV-transformed lymphoblastoid cell lines (LCLs) without the help of EBNA3C. This was demonstrated using a variety of LCLs carrying either knockout, revertant, or conditional EBNA3 recombinants. Investigating the kinetics of EBNA3A-mediated changes in STK39 expression showed that STK39 becomes derepressed quickly after EBNA3A inactivation. This derepression is reversible as EBNA3A reactivation represses STK39 in the same cells expressing a conditional EBNA3A. STK39 is silenced shortly after primary B cell infection by EBV, and no STK39 -encoded protein (SPAK) is detected 3 weeks postinfection. Chromatin immunoprecipitation (ChIP) analysis indicates that EBNA3A directly binds to a regulatory region downstream of the STK39 transcription start site. For the first time, we demonstrated that the polycomb repressive complex 2 with the deposition of the repressive mark H3K27me3 is not only important for the maintenance of an EBNA3A target gene ( STK39 ) but is also essential for the initial establishment of its silencing. Finally, we showed that DNA methyltransferases are involved in the EBNA3A-mediated repression of STK39 IMPORTANCE EBV is well known for its ability to transform B lymphocytes to continuously proliferating lymphoblastoid cell lines. This is achieved in part by the reprogramming of cellular gene transcription by EBV transcription factors, including the EBNA3 proteins that play a crucial role in this process. In the present study, we found that EBNA3A epigenetically silences STK39 This is the first gene where EBNA3A has been found to exert its repressive role by itself, without needing its coregulators EBNA3B and EBNA3C. Furthermore, we demonstrated that the polycomb repressor complex is essential for EBNA3A-mediated repression of STK39 Findings in this study provide new insights into the regulation of cellular genes by the transcription factor EBNA3A. Copyright © 2018 Bazot et al.
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MiniCORVET is a Vps8-containing early endosomal tether in Drosophila.
Lőrincz, Péter; Lakatos, Zsolt; Varga, Ágnes; Maruzs, Tamás; Simon-Vecsei, Zsófia; Darula, Zsuzsanna; Benkő, Péter; Csordás, Gábor; Lippai, Mónika; Andó, István; Hegedűs, Krisztina; Medzihradszky, Katalin F; Takáts, Szabolcs; Juhász, Gábor
2016-06-02
Yeast studies identified two heterohexameric tethering complexes, which consist of 4 shared (Vps11, Vps16, Vps18 and Vps33) and 2 specific subunits: Vps3 and Vps8 (CORVET) versus Vps39 and Vps41 (HOPS). CORVET is an early and HOPS is a late endosomal tether. The function of HOPS is well known in animal cells, while CORVET is poorly characterized. Here we show that Drosophila Vps8 is highly expressed in hemocytes and nephrocytes, and localizes to early endosomes despite the lack of a clear Vps3 homolog. We find that Vps8 forms a complex and acts together with Vps16A, Dor/Vps18 and Car/Vps33A, and loss of any of these proteins leads to fragmentation of endosomes. Surprisingly, Vps11 deletion causes enlargement of endosomes, similar to loss of the HOPS-specific subunits Vps39 and Lt/Vps41. We thus identify a 4 subunit-containing miniCORVET complex as an unconventional early endosomal tether in Drosophila.
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Dowel bar retrofit performance in Wisconsin.
DOT National Transportation Integrated Search
2010-05-01
In 1999, WisDOT constructed test sections on I-39 to evaluate the dowel bar retrofit (DBR) rehabilitation technique for faulted concrete pavement slabs. Two years later, mortar deterioration and debonding were noted in the dowel slots. In response to...
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Chen, Yang; Ren, Xiaofeng; Zhang, Guo-Qiang; Xu, Rong
2013-01-01
Visual information is a crucial aspect of medical knowledge. Building a comprehensive medical image base, in the spirit of the Unified Medical Language System (UMLS), would greatly benefit patient education and self-care. However, collection and annotation of such a large-scale image base is challenging. To combine visual object detection techniques with medical ontology to automatically mine web photos and retrieve a large number of disease manifestation images with minimal manual labeling effort. As a proof of concept, we first learnt five organ detectors on three detection scales for eyes, ears, lips, hands, and feet. Given a disease, we used information from the UMLS to select affected body parts, ran the pretrained organ detectors on web images, and combined the detection outputs to retrieve disease images. Compared with a supervised image retrieval approach that requires training images for every disease, our ontology-guided approach exploits shared visual information of body parts across diseases. In retrieving 2220 web images of 32 diseases, we reduced manual labeling effort to 15.6% while improving the average precision by 3.9% from 77.7% to 81.6%. For 40.6% of the diseases, we improved the precision by 10%. The results confirm the concept that the web is a feasible source for automatic disease image retrieval for health image database construction. Our approach requires a small amount of manual effort to collect complex disease images, and to annotate them by standard medical ontology terms.
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Methner, Katharina; Mulch, Andreas; Teyssier, Christian; Wells, Michael L.; Cosca, Michael A.; Gottardi, Raphael; Gebelin, Aude; Chamberlain, C. Page
2015-01-01
Metamorphic core complexes (MCCs) in the North American Cordillera reflect the effects of lithospheric extension and contribute to crustal adjustments both during and after a protracted subduction history along the Pacific plate margin. While the Miocene-to-recent history of most MCCs in the Great Basin, including the Raft River-Albion-Grouse Creek MCC, is well documented, early Cenozoic tectonic fabrics are commonly severely overprinted. We present stable isotope, geochronological (40Ar/39Ar), and microstructural data from the Raft River detachment shear zone. Hydrogen isotope ratios of syntectonic white mica (δ2Hms) from mylonitic quartzite within the shear zone are very low (−90‰ to −154‰, Vienna SMOW) and result from multiphase synkinematic interaction with surface-derived fluids. 40Ar/39Ar geochronology reveals Eocene (re)crystallization of white mica with δ2Hms ≥ −154‰ in quartzite mylonite of the western segment of the detachment system. These δ2Hms values are distinctively lower than in localities farther east (δ2Hms ≥ −125‰), where 40Ar/39Ar geochronological data indicate Miocene (18–15 Ma) extensional shearing and mylonitic fabric formation. These data indicate that very low δ2H surface-derived fluids penetrated the brittle-ductile transition as early as the mid-Eocene during a first phase of exhumation along a detachment rooted to the east. In the eastern part of the core complex, prominent top-to-the-east ductile shearing, mid-Miocene 40Ar/39Ar ages, and higher δ2H values of recrystallized white mica, indicate Miocene structural and isotopic overprinting of Eocene fabrics.
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Novel strategies to construct complex synthetic vectors to produce DNA molecular weight standards.
Chen, Zhe; Wu, Jianbing; Li, Xiaojuan; Ye, Chunjiang; Wenxing, He
2009-05-01
DNA molecular weight standards (DNA markers, nucleic acid ladders) are commonly used in molecular biology laboratories as references to estimate the size of various DNA samples in electrophoresis process. One method of DNA marker production is digestion of synthetic vectors harboring multiple DNA fragments of known sizes by restriction enzymes. In this article, we described three novel strategies-sequential DNA fragment ligation, screening of ligation products by polymerase chain reaction (PCR) with end primers, and "small fragment accumulation"-for constructing complex synthetic vectors and minimizing the mass differences between DNA fragments produced from restrictive digestion of synthetic vectors. The strategy could be applied to construct various complex synthetic vectors to produce any type of low-range DNA markers, usually available commercially. In addition, the strategy is useful for single-step ligation of multiple DNA fragments for construction of complex synthetic vectors and other applications in molecular biology field.
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2003-08-18
KENNEDY SPACE CENTER, FLA. - Joe Bartoszek, NASA, is a member of the research team conducting underwater acoustic research in the Launch Complex 39 turn basin near Launch Pad 39A. Several government agencies, including NASA, NOAA, the Navy, the Coast Guard, and the Florida Fish and Wildlife Commission are involved in the testing. The research involves demonstrations of passive and active sensor technologies, with applications in fields ranging from marine biological research to homeland security. The work is also serving as a pilot project to assess the cooperation between the agencies involved. Equipment under development includes a passive acoustic monitor developed by NASA’s Jet Propulsion Laboratory, and mobile robotic sensors from the Navy’s Mobile Diving and Salvage Unit.
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Large-scale systems: Complexity, stability, reliability
NASA Technical Reports Server (NTRS)
Siljak, D. D.
1975-01-01
After showing that a complex dynamic system with a competitive structure has highly reliable stability, a class of noncompetitive dynamic systems for which competitive models can be constructed is defined. It is shown that such a construction is possible in the context of the hierarchic stability analysis. The scheme is based on the comparison principle and vector Liapunov functions.
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STS-30 Atlantis, OV-104, at KSC LC Pad 39B atop mobile launcher platform
NASA Technical Reports Server (NTRS)
1989-01-01
STS-30 Atlantis, Orbiter Vehicle (OV) 104, arrives at Kennedy Space Center (KSC) Launch Complex (LC) Pad 39B atop mobile launcher platform. The fixed service structure (FSS) towers above OV-104, its external tank (ET), and its solid rocket boosters (SRBs). The rotating service structure (RSS) is retracted. The launch tower catwalks are also retracted.
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STS-32 Columbia, OV-102, is positioned on the hard stand at KSC LC Pad 39A
1989-11-28
S89-51983 (18 Nov 1989) --- Roll-out of the Space Shuttle Columbia is completed as the vehicle, atop the Mobile Launcher Platform, is positioned on the hard stand at Pad 39A. The approximately eight-hour journey from the Vehicle Assembly Building began at 2:32 a.m. EST. This marks the first time a Space Shuttle has been at Pad A at Launch Complex 39 since January 12, 1986, when Columbia was launched on mission 61C. Pad A will next be used for the launch of Columbia and a five person crew on the STS-32 mission, presently scheduled for no earlier than December 18, 1989.
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STS-98 Atlantis rolls out to Pad 39A for the second time
NASA Technical Reports Server (NTRS)
2001-01-01
KENNEDY SPACE CENTER, Fla. -- Under wispy white clouds, Space Shuttle Atlantis slowly moves toward the Rotating and Fixed Service Structures on Launch Pad 39A. The 80-foot-tall white lighting mast is seen atop the FSS. Atlantis will fly on mission STS-98, the seventh construction flight to the International Space Station, carrying the U.S. Laboratory, named Destiny. The lab will have five system racks already installed inside the module. After delivery of electronics in the lab, electrically powered attitude control for Control Moment Gyroscopes will be activated. Atlantis is scheduled for launch no earlier than Jan. 19, 2001, with a crew of five.
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The method of selecting an integrated development territory for the high-rise unique constructions
NASA Astrophysics Data System (ADS)
Sheina, Svetlana; Shevtsova, Elina; Sukhinin, Alexander; Priss, Elena
2018-03-01
On the basis of data provided by the Department of architecture and urban planning of the city of Rostov-on-don, the problem of the choice of the territory for complex development that will be in priority for the construction of high-rise and unique buildings is solved. The objective of the study was the development of a methodology for selection of the area and the implementation of the proposed method on the example of evaluation of four-territories complex development. The developed method along with standard indicators of complex evaluation considers additional indicators that assess the territory from the position of high-rise unique building. The final result of the study is the rankings of the functional priority areas that takes into account the construction of both residential and public and business objects of unique high-rise construction. The use of the developed methodology will allow investors and customers to assess the investment attractiveness of the future unique construction project on the proposed site.
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Hörmeyer, Ina; Renner, Gregor
2013-09-01
For individuals with complex communication needs, one of the most frequent communicative strategies is the co-construction of meaning with familiar partners. This preliminary single-case study gives insight into a special sequential pattern of co-construction processes - the search sequence - particularly in relation to the processes of confirming and denying meanings proposed by familiar interaction partners. Five different conversations between an adult with cerebral palsy and complex communication needs and two familiar co-participants were videotaped and analyzed using the methodology of conversation analysis (CA). The study revealed that confirmations and denials are not simply two alternative actions, but that several possibilities to realize confirmations and denials exist that differ in their frequency and that have different consequences for the sequential context. This study of confirmations and denials demonstrates that co-construction processes are more complex than have previously been documented.
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2003-08-18
KENNEDY SPACE CENTER, FLA. - Researchers utilize several types of watercraft to conduct underwater acoustic research in the Launch Complex 39 turn basin near Launch Pad 39A. Several government agencies, including NASA, NOAA, the Navy, the Coast Guard, and the Florida Fish and Wildlife Commission are involved in the testing. The research involves demonstrations of passive and active sensor technologies, with applications in fields ranging from marine biological research to homeland security. The work is also serving as a pilot project to assess the cooperation between the agencies involved. Equipment under development includes a passive acoustic monitor developed by NASA’s Jet Propulsion Laboratory, and mobile robotic sensors from the Navy’s Mobile Diving and Salvage Unit.
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2009-12-11
CAPE CANAVERAL, Fla. - Concrete is poured into the trenches that will provide the foundation for the walls of the Propellants North Administrative and Maintenance Facility in Launch Complex 39 at NASA's Kennedy Space Center in Florida. A tilt-up construction method is being used to erect a THERMOMASS concrete wall insulation system for the facility's walls. The facility will have a two-story administrative building to house managers, mechanics and technicians who fuel spacecraft at Kennedy adjacent to an 1,800-square-foot single-story shop to store cryogenic fuel transfer equipment. The new facility will feature high-efficiency roofs and walls, “Cool Dry Quiet” air conditioning with energy recovery technology, efficient lighting, and other sustainable features. The facility is striving to qualify for the U.S. Green Building Council’s Leadership in Energy and Environmental Design, or LEED, Platinum certification. If successful, Propellants North will be the first Kennedy facility to achieve this highest of LEED ratings after it is completed in the summer of 2010. The facility was designed for NASA by Jones Edmunds and Associates. Photo credit: NASA/Jim Grossmann
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Osawa, Takuo; Inanaga, Hideko; Numata, Tomoyuki
2015-06-01
Clustered regularly interspaced short palindromic repeat (CRISPR)-derived RNA (crRNA) and CRISPR-associated (Cas) proteins constitute a prokaryotic adaptive immune system (CRISPR-Cas system) that targets and degrades invading genetic elements. The type III-B CRISPR-Cas Cmr complex, composed of the six Cas proteins (Cmr1-Cmr6) and a crRNA, captures and cleaves RNA complementary to the crRNA guide sequence. Here, a Cmr1-deficient functional Cmr (CmrΔ1) complex composed of Pyrococcus furiosus Cmr2-Cmr3, Archaeoglobus fulgidus Cmr4-Cmr5-Cmr6 and the 39-mer P. furiosus 7.01-crRNA was prepared. The CmrΔ1 complex was cocrystallized with single-stranded DNA (ssDNA) complementary to the crRNA guide by the vapour-diffusion method. The crystals diffracted to 2.1 Å resolution using synchrotron radiation at the Photon Factory. The crystals belonged to the triclinic space group P1, with unit-cell parameters a = 75.5, b = 76.2, c = 139.2 Å, α = 90.3, β = 104.8, γ = 118.6°. The asymmetric unit of the crystals is expected to contain one CmrΔ1-ssDNA complex, with a Matthews coefficient of 2.03 Å(3) Da(-1) and a solvent content of 39.5%.
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Willson, T A; Nagley, P
1987-09-01
This work concerns a biochemical genetic study of subunit 9 of the mitochondrial ATPase complex of Saccharomyces cerevisiae. Subunit 9, encoded by the mitochondrial oli1 gene, contains a hydrophilic loop connecting two transmembrane stems. In one particular oli1 mit- mutant 2422, the substitution of a positively charged amino acid in this loop (Arg39----Met) renders the ATPase complex non-functional. A series of 20 revertants, selected for their ability to grow on nonfermentable substrates, has been isolated from mutant 2422. The results of DNA sequence analysis of the oli1 gene in each revertant have led to the recognition of three groups of revertants. Class I revertants have undergone a same-site reversion event: the mutant Met39 is replaced either by arginine (as in wild-type) or lysine. Class II revertants maintain the mutant Met39 residue, but have undergone a second-site reversion event (Asn35----Lys). Two revertants showing an oligomycin-resistant phenotype carry this same second-site reversion in the loop region together with a further amino acid substitution in either of the two membrane-spanning segments of subunit 9 (either Gly23----Ser or Leu53----Phe). Class III revertants contain subunit 9 with the original mutant 2422 sequence, and additionally carry a recessive nuclear suppressor, demonstrated to represent a single gene. The results on the revertants in classes I and II indicate that there is a strict requirement for a positively charged residue in the hydrophilic loop close to the boundary of the lipid bilayer. The precise location of this positive charge is less stringent; in functional ATPase complexes it can be found at either residue 39 or 35. This charged residue is possibly required to interact with some other component of the mitochondrial ATPase complex. These findings, together with hydropathy plots of subunit 9 polypeptides from normal, mutant and revertant strains, led to the conclusion that the hydrophilic loop in normal subunit 9 extends further than previously suggested, with the boundary of the N-terminal membrane-embedded stem lying at residue 34. The possibility is raised that the observed suppression of the 2422 mutant phenotype in class III revertants is manifested through an accommodating change in a nuclear-encoded subunit of the ATPase complex.
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NASA Astrophysics Data System (ADS)
Ng, L. S.; Tan, L. W.; Seow, T. W.
2017-11-01
The effectiveness of the implementation of construction waste reduction through 3R reflects the sustainability in construction waste management. Weak implementation of construction waste reduction through 3R among contractors will lead to unsustainable construction waste management. Increase in construction waste on landfills is critical especially on islands where land is very limited for solid waste disposal. This aim of this paper is to investigate current practice of construction waste reduction through 3R practice among contractors in Penang, Malaysia. The findings reported herein is based on feedbacks from 143 construction contractors of grade CIDB G7, G6 and G5 in Penang and experts from Penang Local Authority, CIDB in Penang and its Headquarters, National Solid Waste Management Department, and Headquarters of Solid Waste and Public Cleansing Management Corporation. Interviews and questionnaire surveys have been found that 3R practice is not mandatory in construction waste management in Penang. Only 39.8% construction contractors practiced 3R in managing their waste. Therefore, 3R practices should be emphasized in construction industry. Reducing wastes through 3R practices in construction industry is a way forward towards sustainable construction waste management especially in expanding the lifetime of landfill.
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Construction continues on the RLV complex at the Shuttle Landing Facility
NASA Technical Reports Server (NTRS)
1999-01-01
At the construction site of the Reusable Launch Vehicle (RLV) complex at KSC, a worker takes a measurement. Located near the Shuttle Landing Facility, the complex will include facilities for related ground support equipment and administrative/ technical support. It will be available to accommodate the Space Shuttle; the X-34 RLV technology demonstrator; the L-1011 carrier aircraft for Pegasus and X-34; and other RLV and X-vehicle programs. The complex is jointly funded by the Spaceport Florida Authority, NASA's Space Shuttle Program and KSC. The facility will be operational in early 2000.
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2010-01-07
CAPE CANAVERAL, Fla. - In Launch Complex 39 at NASA's Kennedy Space Center in Florida, a team of construction workers ensures that the walls of the Propellants North Administrative and Maintenance Facility are installed properly. A tilt-up construction method is being used to erect a THERMOMASS concrete wall insulation system for the facility's walls. In this approach, the exterior layer of concrete for the wall panels is poured and leveled on the building's footprint. Then, prefabricated, predrilled insulation sheets are arranged on top of the unhardened concrete, and connectors, designed to hold the sandwiched layers of concrete and insulation secure, are inserted through the predrilled holes. Next, the structural wythe is poured. Once cured, these panels are lifted upright to form the building's envelope. The facility will have a two-story administrative building to house managers, mechanics and technicians who fuel spacecraft at Kennedy adjacent to an 1,800-square-foot single-story shop to store cryogenic fuel transfer equipment. The new facility will feature high-efficiency roofs and walls, “Cool Dry Quiet” air conditioning with energy recovery technology, efficient lighting, and other sustainable features. The facility is striving to qualify for the U.S. Green Building Council’s Leadership in Energy and Environmental Design, or LEED, Platinum certification. If successful, Propellants North will be the first Kennedy facility to achieve this highest of LEED ratings after it is completed in the summer of 2010. The facility was designed for NASA by Jones Edmunds and Associates. Photo credit: NASA/Jim Grossmann
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2010-01-07
CAPE CANAVERAL, Fla. - In Launch Complex 39 at NASA's Kennedy Space Center in Florida, steady progress is made by a team of construction workers to erect the walls of the Propellants North Administrative and Maintenance Facility. A tilt-up construction method is being used to erect a THERMOMASS concrete wall insulation system for the facility's walls. In this approach, the exterior layer of concrete for the wall panels is poured and leveled on the building's footprint. Then, prefabricated, predrilled insulation sheets are arranged on top of the unhardened concrete, and connectors, designed to hold the sandwiched layers of concrete and insulation secure, are inserted through the predrilled holes. Next, the structural wythe is poured. Once cured, these panels are lifted upright to form the building's envelope. The facility will have a two-story administrative building to house managers, mechanics and technicians who fuel spacecraft at Kennedy adjacent to an 1,800-square-foot single-story shop to store cryogenic fuel transfer equipment. The new facility will feature high-efficiency roofs and walls, “Cool Dry Quiet” air conditioning with energy recovery technology, efficient lighting, and other sustainable features. The facility is striving to qualify for the U.S. Green Building Council’s Leadership in Energy and Environmental Design, or LEED, Platinum certification. If successful, Propellants North will be the first Kennedy facility to achieve this highest of LEED ratings after it is completed in the summer of 2010. The facility was designed for NASA by Jones Edmunds and Associates. Photo credit: NASA/Jim Grossmann
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Karan, Abraar; Amado, Vanda; Vitorino, Pio; Kulber, David; Taela, Atanasio; DeUgarte, Daniel A
2015-11-01
Pediatric burn injuries are one of the leading causes of preventable morbidity and mortality in Sub-Saharan Africa. Research on the complex system of social, economic and cultural factors contributing to burn injuries in this setting is much needed. We conducted a prospective questionnaire-based analysis of pediatric burn patients presenting to the Hospital Central de Maputo. A total of 39 patients were included in the study. Interviews were conducted with the children's caretakers by two trained medical students at the Eduardo Mondlane Medical School in Maputo with the aid of local nursing staff. Most burns occurred from scald wounds (26/39) particularly from bathwater, followed by fire burns (11/39). Burns occurred more frequently in the afternoon (16/39) and evening (16/39). Over one quarter of burns (9/33) occurred in the absence of a caretaker. One-third (12/36) of participants attempted to treat the burn at home prior to bringing the child into the hospital, and roughly two-thirds (24/37) reported using traditional remedies for burn care. The average household had just 2 rooms for an average of 5 family members. Most burns were second degree (25/37). Prevention efforts in this setting are much needed and can be implemented taking complex cultural and social factors into account. Education regarding regulation of water temperature for baths is important, given the prevalence of scald burns. Moreover, the introduction of low-cost, safer cooking technology can help mitigate inhalation injury and reduce fire burns. Additionally, burn care systems must be integrated with local traditional medical interventions to respect local cultural medicinal practices.
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View of Apollo 15 space vehicle on way from VAB to Pad A, Launch Complex 39
1971-05-11
S71-33781 (11 May 1971) --- High angle view showing the Apollo 15 (Spacecraft 112/Lunar Module 10/Saturn 510) space vehicle on the way from the Vehicle Assembly Building (VAB) to Pad A, Launch Complex 39, Kennedy Space Center (KSC). The Saturn V stack and its mobile launch tower are atop a huge crawler-transporter. Apollo 15 is scheduled as the fourth manned lunar landing mission by the National Aeronautics and Space Administration (NASA). The crew men will be astronauts David R. Scott, commander; Alfred M. Worden, command module pilot; and James B. Irwin, lunar module pilot. While astronauts Scott and Irwin descend in the Lunar Module (LM) to explore the moon, astronaut Worden will remain with the Command and Service Modules (CSM) in lunar orbit.
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Pad 39B Flame Trench Brick Work
2016-10-26
A construction worker with J.P. Donovan of Rockledge, Florida, checks to make sure new heat-resistant bricks attached to the north side of the flame trench are level at Launch Pad 39B at NASA’s Kennedy Space Center in Florida. The Pad B flame trench is being refurbished to support the launch of NASA’s Space Launch System rocket. The Ground Systems Development and Operations (GSDO) Program at Kennedy is helping transform the space center into a multi-user spaceport and prepare for Exploration Mission 1, deep space missions, and NASA's Journey to Mars. For more information about GSDO, visit: http://www.nasa.gov/groundsystems.
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2009-01-02
CAPE CANAVERAL, Fla. – On Launch Pad 39B at NASA's Kennedy Space Center in Florida, a crane completes construction of one of the towers in the new lightning protection system for the Constellation Program and Ares/Orion launches. Each of the three new lightning towers will be 500 feet tall with an additional 100-foot fiberglass mast atop supporting a wire catenary system. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009. Photo credit: NASA/Troy Cryder
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2009-01-22
CAPE CANAVERAL, Fla. – Progress is being made on construction of the new lightning towers on Launch Pad 39B at NASA's Kennedy Space Center in Florida. New sections are being added with the help of a giant crane. Three new lightning towers on the pad will be 500 feet tall with an additional 100-foot fiberglass mast atop supporting a wire catenary system. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Photo credit: NASA/Kim Shiflett
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STS-102 crew meets with media at Launch Pad 39B during TCDT
NASA Technical Reports Server (NTRS)
2001-01-01
KENNEDY SPACE CENTER, Fla. -- STS-102 Commander James Wetherbee talks about the mission during a media event at the slidewire basket landing near Launch Pad 39B. He and other crew members are at KSC for Terminal Countdown Demonstration Test activities, which also include a simulated launch countdown. STS-102 is the eighth construction flight to the International Space Station, with Space Shuttle Discovery carrying the Multi-Purpose Logistics Module Leonardo. Discovery will also be transporting the Expedition Two crew to the Space Station, to replace Expedition One, who will return to Earth with Discovery. Launch on mission STS-102 is scheduled for March 8.
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2009-01-26
CAPE CANAVERAL, Fla. – Construction of the towers on Launch Pad 39B at NASA's Kennedy Space Center in Florida continues on the new lightning protection system for the Constellation Program and Ares/Orion launches. Here, a 100-foot fiberglass lightning mast is being prepared to be lifted on top of one of the 500-foot towers. The mast will support a wire catenary system. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009.
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ERIC Educational Resources Information Center
Inoue, Chihiro
2016-01-01
The constructs of complexity, accuracy and fluency (CAF) have been used extensively to investigate learner performance on second language tasks. However, a serious concern is that the variables used to measure these constructs are sometimes used conventionally without any empirical justification. It is crucial for researchers to understand how…
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NASA Astrophysics Data System (ADS)
Khundjua, A. G.; Ptitsin, A. G.; Brovkina, E. A.
2018-01-01
The internal structure of experimentally observed self-accommodation complexes of martensite crystals, which is determined by the system of twinning planes, is studied in this work. The direct correlation of the construction type of the complexes with the subgroups of the austenite lattice symmetry group is shown.
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STS-27 Atlantis, OV-104, lifts off from KSC Launch Complex (LC) Pad 39B
1988-12-02
STS027-S-005 (Dec 2, 1988) --- Space Shuttle Atlantis is launched from Kennedy Space Center's (KSC) Pad 39-B at 9:30 a.m. EST, on a Department of Defense (DOD) dedicated mission. This is the third mission for the orbiter Atlantis. Crew members are: Commander Robert L. "Hoot" Gibson; Pilot Guy S. Gardner; and Mission Specialists Jerry L. Ross, William M. Shepherd and Richard M. (Mike) Mullane.
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High Spatial Resolution 40Ar/39Ar Geochronology of Lunar Impact Melt Rocks
NASA Astrophysics Data System (ADS)
Mercer, Cameron Mark
Impact cratering has played a key role in the evolution of the solid surfaces of Solar System bodies. While much of Earth’s impact record has been erased, its Moon preserves an extensive history of bombardment. Quantifying the timing of lunar impact events is crucial to understanding how impacts have shaped the evolution of early Earth, and provides the basis for estimating the ages of other cratered surfaces in the Solar System. Many lunar impact melt rocks are complex mixtures of glassy and crystalline “melt” materials and inherited clasts of pre-impact minerals and rocks. If analyzed in bulk, these samples can yield complicated incremental release 40Ar/39Ar spectra, making it challenging to uniquely interpret impact ages. Here, I have used a combination of high-spatial resolution 40Ar/39Ar geochronology and thermal-kinetic modeling to gain new insights into the impact histories recorded by such lunar samples. To compare my data to those of previous studies, I developed a software tool to account for differences in the decay, isotopic, and monitor age parameters used for different published 40Ar/39Ar datasets. Using an ultraviolet laser ablation microprobe (UVLAMP) system I selectively dated melt and clast components of impact melt rocks collected during the Apollo 16 and 17 missions. UVLAMP 40Ar/39Ar data for samples 77135, 60315, 61015, and 63355 show evidence of open-system behavior, and provide new insights into how to interpret some complexities of published incremental heating 40Ar/39Ar spectra. Samples 77115, 63525, 63549, and 65015 have relatively simple thermal histories, and UVLAMP 40Ar/39Ar data for the melt components of these rocks indicate the timing of impact events—spanning hundreds of millions of years—that influenced the Apollo 16 and 17 sites. My modeling and UVLAMP 40Ar/39Ar data for sample 73217 indicate that some impact melt rocks can quantitatively retain evidence for multiple melt-producing impact events, and imply that such polygenetic rocks should be regarded as high-value sampling opportunities during future exploration missions to cratered planetary surfaces. Collectively, my results complement previous incremental heating 40Ar/39Ar studies, and support interpretations that the Moon experienced a prolonged period of heavy bombardment early in its history.
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Complex network construction based on user group attention sequence
NASA Astrophysics Data System (ADS)
Zhang, Gaowei; Xu, Lingyu; Wang, Lei
2018-04-01
In the traditional complex network construction, it is often to use the similarity between nodes, build the weight of the network, and finally build the network. However, this approach tends to focus only on the coupling between nodes, while ignoring the information transfer between nodes and the transfer of directionality. In the network public opinion space, based on the set of stock series that the network groups pay attention to within a certain period of time, we vectorize the different stocks and build a complex network.
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2009-12-11
CAPE CANAVERAL, Fla. - Construction of the walls for the Propellants North Administrative and Maintenance Facility begins in Launch Complex 39 at NASA's Kennedy Space Center in Florida. A tilt-up construction method is being used to erect a THERMOMASS concrete wall insulation system for the facility's walls. In this approach, the exterior layer of concrete for the wall panels is poured and leveled on the building's footprint. Then, prefabricated, predrilled insulation sheets are arranged on top of the unhardened concrete, and connectors, designed to hold the sandwiched layers of concrete and insulation secure, are inserted through the predrilled holes. Next, the structural wythe is poured. Once cured, these panels are lifted upright to form the building's envelope. The facility will have a two-story administrative building to house managers, mechanics and technicians who fuel spacecraft at Kennedy adjacent to an 1,800-square-foot single-story shop to store cryogenic fuel transfer equipment. The new facility will feature high-efficiency roofs and walls, “Cool Dry Quiet” air conditioning with energy recovery technology, efficient lighting, and other sustainable features. The facility is striving to qualify for the U.S. Green Building Council’s Leadership in Energy and Environmental Design, or LEED, Platinum certification. If successful, Propellants North will be the first Kennedy facility to achieve this highest of LEED ratings after it is completed in the summer of 2010. The facility was designed for NASA by Jones Edmunds and Associates. Photo credit: NASA/Jim Grossmann
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2014-06-11
CAPE CANAVERAL, Fla. -- Modifications continue on the Mobile Launcher, or ML, at the Mobile Launcher Park Site at NASA’s Kennedy Space Center in Florida. In view from the top of the ML is the crawlerway that leads to Launch Pads 39A and 39B. The ML is being modified and strengthened to accommodate the weight, size and thrust at launch of NASA's Space Launch System, or SLS, and Orion spacecraft. In 2013, the agency awarded a contract to J.P. Donovan Construction Inc. of Rockledge, Fla., to modify the ML, which is one of the key elements of ground support equipment that is being upgraded by the Ground Systems Development and Operations Program office at Kennedy. The existing 24-foot exhaust hole is being enlarged and strengthened for the larger, heavier SLS rocket. The ML will carry the SLS rocket and Orion spacecraft to Launch Pad 39B for its first mission, Exploration Mission-1, in 2017. Photo credit: NASA/Daniel Casper
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SpaceX CRS-10 Post Launch News Conference
2017-02-19
In the Press Site auditorium of NASA's Kennedy Space Center in Florida, Pam Underwood, manager of the Operations Integration Division of the Federal Aviation Administration Office of Commercial Space Transportation, speaks to the news media at a post-launch news conference following the liftoff of SpaceX CRS-10, a commercial resupply services mission to the International Space Station. SpaceX CRS-10 lifted off atop a Falcon 9 rocket from Kennedy's Launch Complex 39A at 9:39 a.m. EST.
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17. Photocopy of a photograph (original in the Collection of ...
17. Photocopy of a photograph (original in the Collection of the Salt Lake City Engineer's Office)--ca. 1925--GENERAL VIEW OF DOWNSTREAM SIDE OF DAM FOLLOWING COMPLETION OF CONSTRUCTION - Mountain Dell Dam, Parley's Canyon, Northwest side of I-80, West of State Route 39, Salt Lake City, Salt Lake County, UT
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10 CFR 39.15 - Agreement with well owner or operator.
Code of Federal Regulations, 2010 CFR
2010-01-01
... sealed source becomes lodged in the well, a reasonable effort will be made to recover it. (2) A person... identification plaque, constructed of long lasting material such as stainless steel, brass, bronze, or monel... appropriate; (E) The well name and well identification number(s) or other designation; (F) An identification...
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10 CFR 39.15 - Agreement with well owner or operator.
Code of Federal Regulations, 2011 CFR
2011-01-01
... sealed source becomes lodged in the well, a reasonable effort will be made to recover it. (2) A person... identification plaque, constructed of long lasting material such as stainless steel, brass, bronze, or monel... appropriate; (E) The well name and well identification number(s) or other designation; (F) An identification...
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Fogarty, Laurel; Creanza, Nicole
2017-12-05
Niche construction is a process through which organisms alter their environments and, in doing so, influence or change the selective pressures to which they are subject. 'Cultural niche construction' refers specifically to the effect of cultural traits on the selective environments of other biological or cultural traits and may be especially important in human evolution. In addition, the relationship between population size and cultural accumulation has been the subject of extensive debate, in part because anthropological studies have demonstrated a significant association between population size and toolkit complexity in only a subset of studied cultures. Here, we review the role of cultural innovation in constructing human evolutionary niches and introduce a new model to describe the accumulation of human cultural traits that incorporates the effects of cultural niche construction. We consider the results of this model in light of available data on human toolkit sizes across populations to help elucidate the important differences between food-gathering societies and food-producing societies, in which niche construction may be a more potent force. These results support the idea that a population's relationship with its environment, represented here by cultural niche construction, should be considered alongside population size in studies of cultural complexity.This article is part of the themed issue 'Process and pattern in innovations from cells to societies'. © 2017 The Author(s).
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High precision ages from the Torres del Paine Intrusion, Chile
NASA Astrophysics Data System (ADS)
Michel, J.; Baumgartner, L.; Cosca, M.; Ovtcharova, M.; Putlitz, B.; Schaltegger, U.
2006-12-01
The upper crustal bimodal Torres del Paine Intrusion, southern Chile, consists of the lower Paine-Mafic- Complex and the upper Paine-Granite. Geochronologically this bimodal complex is not well studied except for a few existing data from Halpern (1973) and Sanchez (2006). The aim of this study is to supplement the existing data and to constrain the age relations between the major magmatic pulses by applying high precision U-Pb dating on accessory zircons and 40Ar/39Ar-laser-step-heating-ages on biotites from the Torres del Paine Intrusion. The magmatic rocks from mafic complex are fine to medium-grained and vary in composition from quartz- monzonites to granodiorites and gabbros. Coarse-grained olivine gabbros have intruded these rocks in the west. The granitic body is represented by a peraluminous, biotite-orthoclase-granite and a more evolved leucocratic granite in the outer parts towards the host-rock. Field observations suggest a feeder-zone for the granite in the west and that the granite postdates the mafic complex. Two granite samples of the outermost margins in the Northeast and South were analyzed. The zircons were dated by precise isotope-dilution U-Pb techniques of chemically abraded single grains. The data are concordant within the analytical error and define weighted mean 206/238U ages of 12.59 ± 0.03 Ma and 12.58 ± 0.01 Ma for the two samples respectively. A 40Ar/39Ar-age for the second sample yield a date of 12.37 ± 0.11 Ma. Three 40Ar/39Ar -ages of biotites were obtained for rocks belonging to the mafic complex. A hbl-bio- granodiorite from the central part, approximately 150 m below the subhorizontal contact with the granite, gives an age of 12.81 ± 0.11 Ma. A hbl-bio-granodiorite and an olivine-gabbro west of the feeder-zone date at 12.42 ± 0.14 Ma and 12.49 ± 0.11 Ma, respectively. The obtained older age of 12.81 Ma for the granodiorite in the central part is consistent with structural relationships of brittle fracturing of the mafic complex by the granite and we conclude that some parts of the mafic complex were emplaced before the granite. The well defined 206/238U-age for zircons and the slightly younger 40Ar/39Ar -ages for biotites of both rock suites show that emplacement and cooling of the Torres del Paine Intrusion took place in a relatively short time-frame. Halpern, 1973, Geological Society of America Bulletin, 84/7: 2407-2422. Sanchez et.al., 2006. V SSAGI, Punta del Este, April 2006.
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Probabilistic Survivability Versus Time Modeling
NASA Technical Reports Server (NTRS)
Joyner, James J., Sr.
2016-01-01
This presentation documents Kennedy Space Center's Independent Assessment work completed on three assessments for the Ground Systems Development and Operations (GSDO) Program to assist the Chief Safety and Mission Assurance Officer during key programmatic reviews and provided the GSDO Program with analyses of how egress time affects the likelihood of astronaut and ground worker survival during an emergency. For each assessment, a team developed probability distributions for hazard scenarios to address statistical uncertainty, resulting in survivability plots over time. The first assessment developed a mathematical model of probabilistic survivability versus time to reach a safe location using an ideal Emergency Egress System at Launch Complex 39B (LC-39B); the second used the first model to evaluate and compare various egress systems under consideration at LC-39B. The third used a modified LC-39B model to determine if a specific hazard decreased survivability more rapidly than other events during flight hardware processing in Kennedy's Vehicle Assembly Building.
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NASA Astrophysics Data System (ADS)
Beliakov, Sergei
2018-03-01
Investment projects of high-rise construction have a number of features that determine specific risks and additional opportunities that require analysis and accounting in the formation of an effective project concept. The most significant features of high-rise construction include long construction time, complexity of technical and technological solutions, complexity of decisions on the organization of construction and operation, high cost of construction and operation, complexity in determining the ratio of areas designed to accommodate different functional areas, when organizing and coordinating the operation of the facility, with internal zoning. Taking into account the specificity of high-rise construction, among the factors determining the effectiveness of projects, it is advisable to consider as key factors: organizational, technological and investment factors. Within the framework of the article, the author singled out key particular functions for each group of factors under consideration, and also developed a system of principles for the formation of an effective concept of multifunctional high-rise construction investment projects, including the principle of logistic efficiency, the principle of optimal functional zoning, the principle of efficiency of equipment use, the principle of optimizing technological processes, the principle maximization of income, the principle of fund management, the principle of risk management . The model of formation of an effective concept of investment projects of multifunctional high-rise construction developed by the author can contribute to the development of methodological tools in the field of managing the implementation of high-rise construction projects, taking into account their specificity in the current economic conditions.
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ERIC Educational Resources Information Center
Turvey, Keith
2012-01-01
This article argues that to understand how new technologies and media can become co-agents in the process of pedagogical change, we first need to understand teachers' complex relationship with new technologies and media in both their personal and their professional lives. A conceptual framework is delineated for constructing a complex narrative…
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Gambarte Tudela, Julian; Capmany, Anahi; Romao, Maryse; Quintero, Cristian; Miserey-Lenkei, Stephanie; Raposo, Graca; Goud, Bruno; Damiani, Maria Teresa
2015-08-15
Given their obligate intracellular lifestyle, Chlamydia trachomatis ensure that they have access to multiple host sources of essential lipids by interfering with vesicular transport. These bacteria hijack Rab6-, Rab11- and Rab14-controlled trafficking pathways to acquire sphingomyelin from the Golgi complex. Another important source of sphingolipids, phospholipids and cholesterol are multivesicular bodies (MVBs). Despite their participation in chlamydial inclusion development and bacterial replication, the molecular mechanisms mediating the interaction between MVBs and chlamydial inclusions remain unknown. In the present study, we demonstrate that Rab39a labels a subset of late endocytic vesicles - mainly MVBs - that move along microtubules. Moreover, Rab39a is actively recruited to chlamydial inclusions throughout the pathogen life cycle by a bacterial-driven process that depends on the Rab39a GTP- or GDP-binding state. Interestingly, Rab39a participates in the delivery of MVBs and host sphingolipids to maturing chlamydial inclusions, thereby promoting inclusion growth and bacterial development. Taken together, our findings indicate that Rab39a favours chlamydial replication and infectivity. This is the first report showing that a late endocytic Rab GTPase is involved in chlamydial infection development. © 2015. Published by The Company of Biologists Ltd.
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2001-01-03
KENNEDY SPACE CENTER, FLA. -- In the Payload Changeout Room at Launch Pad 39A, a technician works switches on the Payload Ground-Handling Mechanism hook instrumentation unit that will move the U.S. Lab Destiny out of the payload canister and into the PCR. Destiny will then be transferred to the payload bay of Atlantis for mission STS-98. Destiny, a key element in the construction of the International Space Station is designed for space science experiments. STS-98 is the seventh construction flight to the ISS. Launch of STS-98 is scheduled for Jan. 19 at 2:11 a.m. EST
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Photocopy of drawing. VEHICLE ASSEMBLY BUILDING MODIFICATIONS. NASA John F. ...
Photocopy of drawing. VEHICLE ASSEMBLY BUILDING MODIFICATIONS. NASA John F. Kennedy Space Center, Florida. File Number 79K05424, Seelye Stevenson Value & Knecht, March 1975. HIGH BAY 3, EXTENSIBLE WORK PLATFORM D, MAIN FLOOR PLAN, ARCHITECTURAL. Sheet 39 of 207 - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL
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STS-30 Atlantis, OV-104, on the mobile launcher platform heads to KSC LC pad
NASA Technical Reports Server (NTRS)
1989-01-01
STS-30 Atlantis, Orbiter Vehicle (OV) 104, riding atop the mobile launcher platform and the crawler transporter approaches Kennedy Space Center (KSC) Launch Complex (LC) pad 39B. This backlit view highlights OV-104's profile, the external tank (ET), and one of the two solid rocket boosters (SRBs) as it moves up LC pad 39B incline.
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ERIC Educational Resources Information Center
Odell, John H.
A school construction guide offers key personnel in school development projects information on the complex task of master planning and construction of schools in Australia. This chapter of the guide provides advice on the various types of construction that may be used, the materials available, and some elementary aspects of the services required…
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ERIC Educational Resources Information Center
Theakston, Anna L.; Coates, Anna; Holler, Judith
2014-01-01
Gesture is an important precursor of children's early language development, for example, in the transition to multiword speech and as a predictor of later language abilities. However, it is unclear whether gestural input can influence children's comprehension of complex grammatical constructions. In Study 1, 3- (M = 3 years 5 months) and…
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Pad 39B Flame Trench Brick Work
2016-10-26
Progress continues on the new flame trench at Launch Pad 39B at NASA's Kennedy Space Center in Florida. Construction workers with J.P. Donovan of Rockledge, Florida, prepare new heat-resistant bricks for installation on the north side of the flame trench. The Pad B flame trench is being refurbished to support the launch of NASA’s Space Launch System rocket. The Ground Systems Development and Operations (GSDO) Program at Kennedy is helping transform the space center into a multi-user spaceport and prepare for Exploration Mission 1, deep space missions, and NASA's Journey to Mars. For more information about GSDO, visit: http://www.nasa.gov/groundsystems.
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2013-11-19
CAPE CANAVERAL, Fla. -- At Launch Pad 39B at NASA’s Kennedy Space Center in Florida, construction workers continue to remove the bricks from the flame trench walls that are below and between the left and right crawlerway tracks. The space shuttle-era flame trench deflector has been completely removed. Launch Pad 39B is being refurbished to support NASA’s Space Launch System and other launch vehicles. The Ground Systems Development and Operations, or GSDO, Program office at Kennedy is leading the center’s transformation to safely handle a variety of rockets and spacecraft. For more information about GSDO, visit: http://go.nasa.gov/groundsystems. Photo credit: NASA/Kim Shiflett
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2013-11-19
CAPE CANAVERAL, Fla. -- At Launch Pad 39B at NASA’s Kennedy Space Center in Florida, construction workers continue to remove the bricks from the flame trench walls that are below and between the left and right crawlerway tracks. The space shuttle-era flame trench deflector has been completely removed. Launch Pad 39B is being refurbished to support NASA’s Space Launch System and other launch vehicles. The Ground Systems Development and Operations, or GSDO, Program office at Kennedy is leading the center’s transformation to safely handle a variety of rockets and spacecraft. For more information about GSDO, visit: http://go.nasa.gov/groundsystems. Photo credit: NASA/Kim Shiflett
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2013-11-19
CAPE CANAVERAL, Fla. -- At Launch Pad 39B at NASA’s Kennedy Space Center in Florida, construction workers continue to remove the bricks from the flame trench walls that are below and between the left and right crawlerway tracks. The space shuttle-era flame trench deflector has been completely removed. Launch Pad 39B is being refurbished to support NASA’s Space Launch System and other launch vehicles. The Ground Systems Development and Operations, or GSDO, Program office at Kennedy is leading the center’s transformation to safely handle a variety of rockets and spacecraft. For more information about GSDO, visit: http://go.nasa.gov/groundsystems. Photo credit: NASA/Kim Shiflett
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Pad 39B Flame Trench Brick Work
2016-10-26
Progress continues on the new flame trench at Launch Pad 39B at NASA's Kennedy Space Center in Florida. Construction workers with J.P. Donovan of Rockledge, Florida, attach new heat-resistant bricks on the north side of the flame trench. The Pad B flame trench is being refurbished to support the launch of NASA’s Space Launch System rocket. The Ground Systems Development and Operations (GSDO) Program at Kennedy is helping transform the space center into a multi-user spaceport and prepare for Exploration Mission 1, deep space missions, and NASA's Journey to Mars. For more information about GSDO, visit: http://www.nasa.gov/groundsystems.
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2013-11-19
CAPE CANAVERAL, Fla. -- At Launch Pad 39B at NASA’s Kennedy Space Center in Florida, construction workers continue to remove the bricks from the flame trench walls that are below and between the left and right crawlerway tracks. The space shuttle-era flame trench deflector has been completely removed. Launch Pad 39B is being refurbished to support NASA’s Space Launch System and other launch vehicles. The Ground Systems Development and Operations, or GSDO, Program office at Kennedy is leading the center’s transformation to safely handle a variety of rockets and spacecraft. For more information about GSDO, visit: http://go.nasa.gov/groundsystems. Photo credit: NASA/Kim Shiflett
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2013-11-19
CAPE CANAVERAL, Fla. -- At Launch Pad 39B at NASA’s Kennedy Space Center in Florida, all of the old crawler track panels have been removed from the surface and construction workers are repairing the concrete surface and catacomb roof below. New crawler track panels will be installed. Launch Pad 39B is being refurbished to support NASA’s Space Launch System and other launch vehicles. The Ground Systems Development and Operations, or GSDO, Program office at Kennedy is leading the center’s transformation to safely handle a variety of rockets and spacecraft. For more information about GSDO, visit: http://go.nasa.gov/groundsystems. Photo credit: NASA/Kim Shiflett
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2013-11-19
CAPE CANAVERAL, Fla. -- At Launch Pad 39B at NASA’s Kennedy Space Center in Florida, all of the old crawler track panels have been removed from the surface and construction workers are repairing the concrete surface and catacomb roof below. New crawler track panels will be installed. Launch Pad 39B is being refurbished to support NASA’s Space Launch System and other launch vehicles. The Ground Systems Development and Operations, or GSDO, Program office at Kennedy is leading the center’s transformation to safely handle a variety of rockets and spacecraft. For more information about GSDO, visit: http://go.nasa.gov/groundsystems. Photo credit: NASA/Kim Shiflett
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2009-01-26
CAPE CANAVERAL, Fla. – In the rosy dawn light, construction of the towers on Launch Pad 39B at NASA's Kennedy Space Center in Florida continues on the new lightning protection system for the Constellation Program and Ares/Orion launches. Each of the three new lightning towers will be 500 feet tall with an additional 100-foot fiberglass mast atop supporting a wire catenary system. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009.
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2009-01-26
CAPE CANAVERAL, Fla. – In the rosy dawn light, construction of the towers on Launch Pad 39B at NASA's Kennedy Space Center in Florida continues on the new lightning protection system for the Constellation Program and Ares/Orion launches. Each of the three new lightning towers will be 500 feet tall with an additional 100-foot fiberglass mast atop supporting a wire catenary system. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009.
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NASA Astrophysics Data System (ADS)
Telichenko, Valeriy; Malykha, Galina; Dorogan, Igor
2017-10-01
The article is devoted to the organization of construction of nuclear medicine facilities in Russia. The article describes the main methods of nuclear medical diagnostics, as well as the peculiarities of nuclear medicine facilities that determine the need for application of specific methods for organizing and managing the construction, methods of requirements management in the organization of construction of nuclear medicine facilities. Sustainable development of the transport of radioactive isotopes from the place of production to places of consumption is very important for the safety of the population. The requirements management system is an important and necessary component in organizing the construction of complex facilities, such as nuclear medicine facilities. The author developed and proposed a requirements management system for the design, construction and operation of a nuclear medicine facility, which provides for a cyclic sequence of actions. This system allows reducing the consumption of resources including material and energy during construction and operation of complex objects.
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STS-98 Destiny in Atlantis's payload bay
NASA Technical Reports Server (NTRS)
2001-01-01
KENNEDY SPACE CENTER, Fla. -- The U.S. Laboratory Destiny rests once again in Atlantis'''s payload bay, at Launch Pad 39A. Closing of the payload bay doors is imminent. Destiny, a key element in the construction of the International Space Station, is 28 feet long and weighs 16 tons. This research and command-and-control center is the most sophisticated and versatile space laboratory ever built. It will ultimately house a total of 23 experiment racks for crew support and scientific research. Destiny will be launched Feb. 7 on STS-98, the seventh construction flight to the ISS.
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2011-01-01
Background Evolution of the Brassica species has been recursively affected by polyploidy events, and comparison to their relative, Arabidopsis thaliana, provides means to explore their genomic complexity. Results A genome-wide physical map of a rapid-cycling strain of B. oleracea was constructed by integrating high-information-content fingerprinting (HICF) of Bacterial Artificial Chromosome (BAC) clones with hybridization to sequence-tagged probes. Using 2907 contigs of two or more BACs, we performed several lines of comparative genomic analysis. Interspecific DNA synteny is much better preserved in euchromatin than heterochromatin, showing the qualitative difference in evolution of these respective genomic domains. About 67% of contigs can be aligned to the Arabidopsis genome, with 96.5% corresponding to euchromatic regions, and 3.5% (shown to contain repetitive sequences) to pericentromeric regions. Overgo probe hybridization data showed that contigs aligned to Arabidopsis euchromatin contain ~80% of low-copy-number genes, while genes with high copy number are much more frequently associated with pericentromeric regions. We identified 39 interchromosomal breakpoints during the diversification of B. oleracea and Arabidopsis thaliana, a relatively high level of genomic change since their divergence. Comparison of the B. oleracea physical map with Arabidopsis and other available eudicot genomes showed appreciable 'shadowing' produced by more ancient polyploidies, resulting in a web of relatedness among contigs which increased genomic complexity. Conclusions A high-resolution genetically-anchored physical map sheds light on Brassica genome organization and advances positional cloning of specific genes, and may help to validate genome sequence assembly and alignment to chromosomes. All the physical mapping data is freely shared at a WebFPC site (http://lulu.pgml.uga.edu/fpc/WebAGCoL/brassica/WebFPC/; Temporarily password-protected: account: pgml; password: 123qwe123. PMID:21955929
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STS-28 Columbia, OV-102, lifts off from KSC Launch Complex Pad 39B
1989-08-08
STS028-S-004 (8 Aug. 1989) --- Framed by Florida vegetation, Space Shuttle Columbia soars toward space for the STS-28 mission from Launch Pad 39-B. The spacecraft renews flight after a period of three and a half years, this time with five crewmembers aboard. Onboard the spacecraft are astronauts Brewster H. Shaw Jr., Richard N. Richards, David C. Leestma, James C. Adamson and Mark N. Brown. The last time Columbia was in space was in January of 1986.
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NASA Technical Reports Server (NTRS)
2003-01-01
KENNEDY SPACE CENTER, FLA. Smoke from a successful controlled burn near KSCs Launch Complex 39 surrounds the Vehicle Assembly Building and spreads across the horizon. The water in the foreground is the Banana River.
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49 CFR 178.65 - Specification 39 non-reusable (non-refillable) cylinders.
Code of Federal Regulations, 2013 CFR
2013-10-01
...) Material; steel or aluminum. The cylinder must be constructed of either steel or aluminum conforming to the following requirements: (1) Steel. (i) The steel analysis must conform to the following: Ladle analysis... percent .05 .06 (ii) For a cylinder made of seamless steel tubing with integrally formed ends, hot drawn...
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49 CFR 178.65 - Specification 39 non-reusable (non-refillable) cylinders.
Code of Federal Regulations, 2010 CFR
2010-10-01
...) Material; steel or aluminum. The cylinder must be constructed of either steel or aluminum conforming to the following requirements: (1) Steel. (i) The steel analysis must conform to the following: Ladle analysis... percent .05 .06 (ii) For a cylinder made of seamless steel tubing with integrally formed ends, hot drawn...
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49 CFR 178.65 - Specification 39 non-reusable (non-refillable) cylinders.
Code of Federal Regulations, 2014 CFR
2014-10-01
...) Material; steel or aluminum. The cylinder must be constructed of either steel or aluminum conforming to the following requirements: (1) Steel. (i) The steel analysis must conform to the following: Ladle analysis... percent .05 .06 (ii) For a cylinder made of seamless steel tubing with integrally formed ends, hot drawn...
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49 CFR 178.65 - Specification 39 non-reusable (non-refillable) cylinders.
Code of Federal Regulations, 2012 CFR
2012-10-01
...) Material; steel or aluminum. The cylinder must be constructed of either steel or aluminum conforming to the following requirements: (1) Steel. (i) The steel analysis must conform to the following: Ladle analysis... percent .05 .06 (ii) For a cylinder made of seamless steel tubing with integrally formed ends, hot drawn...
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ERIC Educational Resources Information Center
Albinet, Cedric T.; Boucard, Geoffroy; Bouquet, Cedric; Audiffren, Michel
2012-01-01
The processing-speedtheory and the prefrontal-executivetheory are competing theories of cognitive aging. Here we used a theoretically and methodologically-driven framework to investigate the relationships among measures classically used to assess these two theoretical constructs. Twenty-eight young adults (18-32 years) and 39 healthy older adults…
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NASA Astrophysics Data System (ADS)
Kirillova, Ariadna; Prytkova, Oksana O.
2018-03-01
The article is devoted to the features of the formation of the organizational and economic model of the construction of a socio-commercial multifunctional complex for high-rise construction. Authors have given examples of high-altitude multifunctional complexes in Moscow, analyzed the advantages and disadvantages in the implementation of multifunctional complexes, stressed the need for a holistic strategic approach, allowing to take into account the prospects for the development of the city and the creation of a comfortable living environment. Based on the analysis of multifunctional complexes features, a matrix of SWOT analysis was compiled. For the development of cities and improving the quality of life of the population, it is proposed to implement a new type of multifunctional complexes of a joint social and commercial direction, including, along with the implementation of office areas - schools, polyclinics, various sports facilities and cultural and leisure centers (theatrical, dance, studio, etc.). The approach proposed in the article for developing the model is based on a comparative evaluation of the multifunctional complex project of a social and commercial direction implemented at the expense of public-private partnership in the form of a concession agreement and a commercial multifunctional complex being built at the expense of the investor. It has been proved by calculations that the obtained indicators satisfy the conditions of expediency of the proposed organizational-economic model and the project of the social and commercial multifunctional complex is effective.
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DETAIL VIEW OF COMPUTER PANELS, ROOM 8A Cape Canaveral ...
DETAIL VIEW OF COMPUTER PANELS, ROOM 8A - Cape Canaveral Air Force Station, Launch Complex 39, Mobile Launcher Platforms, Launcher Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL
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Aerial views of construction on the RLV hangar at the Shuttle Landing Facility
NASA Technical Reports Server (NTRS)
1999-01-01
Looking southwest, this view shows ongoing construction of a multi-purpose hangar, which is part of the $8 million Reusable Launch Vehicle (RLV) Support Complex at Kennedy Space Center. Edging the construction is Sharkey Road, which parallels the landing strip of the Shuttle Landing Facility nearby. The RLV complex will include facilities for related ground support equipment and administrative/ technical support. It will be available to accommodate the Space Shuttle; the X-34 RLV technology demonstrator; the L-1011 carrier aircraft for Pegasus and X-34; and other RLV and X-vehicle programs. The complex is jointly funded by the Spaceport Florida Authority, NASA's Space Shuttle Program and KSC. The facility will be operational in early 2000.
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NASA Astrophysics Data System (ADS)
Park, Jin-Young; Lee, Dong-Eun; Kim, Byung-Soo
2017-10-01
Due to the increasing concern about climate change, efforts to reduce environmental load are continuously being made in construction industry, and LCA (life cycle assessment) is being presented as an effective method to assess environmental load. Since LCA requires information on construction quantity used for environmental load estimation, however, it is not being utilized in the environmental review in the early design phase where it is difficult to obtain such information. In this study, computation system for construction quantity based on standard cross section of road drainage facilities was developed to compute construction quantity required for LCA using only information available in the early design phase to develop and verify the effectiveness of a model that can perform environmental load estimation. The result showed that it is an effective model that can be used in the early design phase as it revealed a 13.39% mean absolute error rate.
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Bon, S; Méflah, K; Musset, F; Grassi, J; Massoulié, J
1987-12-01
An immunoglobulin M (IgM) monoclonal antibody (mAb Elec-39), obtained against asymmetric acetylcholinesterase (AChE) from Electrophorus electric organs, also reacts with a fraction of globular AChE (amphiphilic G2 form) from Torpedo electric organs. This antibody does not react with asymmetric AChE from Torpedo electric organs or with the enzyme from other tissues of Electrophorus or Torpedo. The corresponding epitope is removed by endoglycosidase F, showing that it is a carbohydrate. The subsets of Torpedo G2 that react or do not react with Elec-39 (Elec-39+ and Elec-39-) differ in their electrophoretic mobility under nondenaturing conditions; the Elec-39+ component also binds the lectins from Pisum sativum and Lens culinaris. Whereas the Elec-39- component is present at the earliest developmental stages examined, an Elec-39+ component becomes distinguishable only around the 70-mm stage. Its proportion increases progressively, but later than the rapid accumulation of the total G2 form. In immunoblots, mAb Elec-39 recognizes a number of proteins other than AChE from various tissues of several species. The specificity of Elec-39 resembles that of a family of anti-carbohydrate antibodies that includes HNK-1, L2, NC-1, NSP-4, as well as IgMs that occur in human neuropathies. Although some human neuropathy IgMs that recognize the myelin-associated glycoprotein did not react with Elec-39+ AChE, mAbs HNK-1, NC-1, and NSP-4 showed the same selectivity as Elec-39 for Torpedo G2 AChE, but differed in the formation of immune complexes.
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Final Flame Trench Brick Installation at Launch Pad 39B
2017-05-09
A view looking up from the north side of the flame trench beneath the pad at Launch Complex 39B at NASA's Kennedy Space Center in Florida. The walls of the flame trench are being upgraded to withstand the intense heat and fire at launch of NASA's Space Launch System rocket with Orion atop. About 96,000 heat-resistant bricks, in three different sizes, were secured to the walls using bonding mortar in combination with adhesive anchors. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to Pad 39B to support the launch of the SLS and Orion spacecraft for Exploration Mission-1 and NASA’s journey to Mars.
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46 CFR 98.30-6 - Lifting a portable tank.
Code of Federal Regulations, 2012 CFR
2012-10-01
... 46 Shipping 4 2012-10-01 2012-10-01 false Lifting a portable tank. 98.30-6 Section 98.30-6... CONSTRUCTION, ARRANGEMENT, AND OTHER PROVISIONS FOR CERTAIN DANGEROUS CARGOES IN BULK Portable Tanks § 98.30-6 Lifting a portable tank. No person may lift a portable tank with another portable tank. [CGD 73-172, 39 FR...
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Martí, Sergio; Andrés, Juan; Moliner, Vicent; Silla, Estanislao; Tuñón, Iñaki; Bertrán, Juan
2008-01-01
The Diels-Alder reaction is one of the most important and versatile transformations available to organic chemists for the construction of complex natural products, therapeutics agents, and synthetic materials. Given the lack of efficient enzymes capable of catalyzing this kind of reaction, it is of interest to ask whether a biological catalyst could be designed from an antibody-combining site. In the present work, a theoretical study of the different behavior of a germline catalytic antibody (CA) and its matured form, 39 A-11, that catalyze a Diels-Alder reaction has been carried out. A free-energy perturbation technique based on a hybrid quantum-mechanics/molecular-mechanics scheme, together with internal energy minimizations, has allowed free-energy profiles to be obtained for both CAs. The profiles show a smaller barrier for the matured form, which is in agreement with the experimental observation. Free-energy profiles were obtained with this methodology, thereby avoiding the much more demanding two-dimensional calculations of the energy surfaces that are normally required to study this kind of reaction. Structural analysis and energy evaluations of substrate-protein interactions have been performed from averaged structures, which allows understanding of how the single mutations carried out during the maturation process can be responsible for the observed fourfold enhancement of the catalytic rate constant. The conclusion is that the mutation effect in this studied germline CA produces a complex indirect effect through coupled movements of the backbone of the protein and the substrate.
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NASA Astrophysics Data System (ADS)
Kurbah, Sunshine D.; Syiemlieh, Ibanphylla; Lal, Ram A.
2018-03-01
Dioxido-vanadium(V) complex has been synthesized in good yield, the complex was characterized by IR, UV-visible and 1H NMR spectroscopy. Single crystal X-ray crystallography techniques were used to assign the structure of the complex. Complex crystallized with monoclinic P21/c space group with cell parameters a (Å) = 39.516(5), b (Å) = 6.2571(11), c (Å) = 17.424(2), α (°) = 90, β (°) = 102.668(12) and γ (°) = 90. The hydrazone ligand is coordinate to metal ion in tridentate fashion through -ONO- donor atoms forming a distorted square pyramidal geometry around the metal ion.
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39 CFR 776.1 - Purpose and policy.
Code of Federal Regulations, 2010 CFR
2010-07-01
... Orders 11990, Protection of Wetlands, and 11988, Floodplain Management, and are adopted pursuant to the... in the Executive Orders. (b) The Postal Service intends to exercise leadership in the acquisition and management of real property, construction of facilities, and disposal of real property, located in...
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NASA Astrophysics Data System (ADS)
Vasilieva, V. N.
2017-11-01
The article deals with the solution of problems in AutoCAD offered at the All-Russian student Olympiads at the section of “Computer graphics” that are not typical for the students of construction specialties. The students are provided with the opportunity to study the algorithm for solving original tasks of high complexity. The article shows how the unknown parameter underlying the construction can be determined using a parametric drawing with geometric constraints and dimensional dependencies. To optimize the mark-up operation, the use of the command for projecting the points and lines of different types onto bodies and surfaces in different directions is shown. For the construction of a spring with a different pitch of turns, the paper describes the creation of a block from a part of the helix and its scaling when inserted into a model with unequal coefficients along the axes. The advantage of the NURBS surface and the application of the “body-surface-surface-NURBS-body” conversion are reflected to enhance the capabilities of both solid and surface modeling. The article’s material introduces construction students into the method of constructing complex models in AutoCAD that are not similar to typical training assignments.
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Kumar, Manoj; Reja, Shahi Imam; Bhalla, Vandana
2012-12-07
A chemosensor 3 based on the N,N-dimethylaminocinnamaldehyde has been synthesized which shows fluorescence turn-on response with Hg(2+) ions, and the in situ prepared 3-Hg(2+) complex has been used for detection of picric acid via electrostatic interaction and construction of a combinatorial logic circuit with NOR and INHIBIT logic functions.
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View of Apollo 15 space vehicle leaving VAB to Pad A, Launch Complex 39
1971-05-11
S71-33786 (11 May 1971) --- The 363-feet tall Apollo (Spacecraft 112/Lunar Module 10/Saturn 510) space vehicle which leaves the Vehicle Assembly Building (VAB) to Pad A, Launch Complex 39, Kennedy Space Center (KSC). The Saturn V stack and its mobile launch tower are atop a huge crawler-transporter. Apollo 15 is scheduled as the fourth manned lunar landing mission by the National Aeronautics and Space Administration (NASA) and is scheduled to lift off on July 26, 1971. The crew men will be astronauts David R. Scott, commander; Alfred M. Worden, command module pilot; and James B. Irwin, lunar module pilot. While astronaut Scott and Irwin will descend in the Lunar Module (LM) to explore the moon, astronaut Worden will remain with the Command and Service Modules (CSM) in lunar orbit.
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Customizable 3D Printed ‘Plug and Play’ Millifluidic Devices for Programmable Fluidics
Tsuda, Soichiro; Jaffery, Hussain; Doran, David; Hezwani, Mohammad; Robbins, Phillip J.; Yoshida, Mari; Cronin, Leroy
2015-01-01
Three dimensional (3D) printing is actively sought after in recent years as a promising novel technology to construct complex objects, which scope spans from nano- to over millimeter scale. Previously we utilized Fused deposition modeling (FDM)-based 3D printer to construct complex 3D chemical fluidic systems, and here we demonstrate the construction of 3D milli-fluidic structures for programmable liquid handling and control of biological samples. Basic fluidic operation devices, such as water-in-oil (W/O) droplet generators for producing compartmentalized mono-disperse droplets, sensor-integrated chamber for online monitoring of cellular growth, are presented. In addition, chemical surface treatment techniques are used to construct valve-based flow selector for liquid flow control and inter-connectable modular devices for networking fluidic parts. As such this work paves the way for complex operations, such as mixing, flow control, and monitoring of reaction / cell culture progress can be carried out by constructing both passive and active components in 3D printed structures, which designs can be shared online so that anyone with 3D printers can reproduce them by themselves. PMID:26558389
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Speijer, Dave
2011-05-01
Recently, constructive neutral evolution has been touted as an important concept for the understanding of the emergence of cellular complexity. It has been invoked to help explain the development and retention of, amongst others, RNA splicing, RNA editing and ribosomal and mitochondrial respiratory chain complexity. The theory originated as a welcome explanation of isolated small scale cellular idiosyncrasies and as a reaction to 'overselectionism'. Here I contend, that in its extended form, it has major conceptual problems, can not explain observed patterns of complex processes, is too easily dismissive of alternative selectionist models, underestimates the creative force of complexity as such, and--if seen as a major evolutionary mechanism for all organisms--could stifle further thought regarding the evolution of highly complex biological processes. Copyright © 2011 WILEY Periodicals, Inc.
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2003-08-18
KENNEDY SPACE CENTER, FLA. - Justin Manley, of the National Oceanic and Atmospheric Administration, is a member of the research team conducting underwater acoustic research in the Launch Complex 39 turn basin near Launch Pad 39A. Several government agencies, including NASA, NOAA, the Navy, the Coast Guard, and the Florida Fish and Wildlife Commission are involved in the testing. The research involves demonstrations of passive and active sensor technologies, with applications in fields ranging from marine biological research to homeland security. The work is also serving as a pilot project to assess the cooperation between the agencies involved. Equipment under development includes a passive acoustic monitor developed by NASA’s Jet Propulsion Laboratory, and mobile robotic sensors from the Navy’s Mobile Diving and Salvage Unit.
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NASA Technical Reports Server (NTRS)
Mata, C.T.; Mata, A.G.
2012-01-01
A Lightning Protection System (LPS) was designed and built at Launch Complex 39B (LC39B), at the Kennedy Space Center (KSC), Florida in 2009. This LPS was instrumented with comprehensive meteorological and lightning data acquisition systems that were deployed from late 2010 until mid 2011. The first direct strikes to the LPS were recorded in March of 2011, when a limited number of sensors had been activated. The lightning instrumentation system detected a total of 70 nearby strokes and 19 direct strokes to the LPS, 2 of the 19 direct strokes to the LPS had two simultaneous ground attachment points (in both instances one channel terminated on the LPS and the other on the nearby ground). Additionally, there are more unaccounted nearby strokes seen on video records for which limited data was acquired either due to the distance of the stroke or the settings of the data acquisition system. Instrumentation deployment chronological milestones, a summary of lightning strikes (direct and nearby), high speed video frames, downconductor currents, and dH/dt and dE/dt typical waveforms for direct and nearby strokes are presented.
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MiniCORVET is a Vps8-containing early endosomal tether in Drosophila
Lőrincz, Péter; Lakatos, Zsolt; Varga, Ágnes; Maruzs, Tamás; Simon-Vecsei, Zsófia; Darula, Zsuzsanna; Benkő, Péter; Csordás, Gábor; Lippai, Mónika; Andó, István; Hegedűs, Krisztina; Medzihradszky, Katalin F; Takáts, Szabolcs; Juhász, Gábor
2016-01-01
Yeast studies identified two heterohexameric tethering complexes, which consist of 4 shared (Vps11, Vps16, Vps18 and Vps33) and 2 specific subunits: Vps3 and Vps8 (CORVET) versus Vps39 and Vps41 (HOPS). CORVET is an early and HOPS is a late endosomal tether. The function of HOPS is well known in animal cells, while CORVET is poorly characterized. Here we show that Drosophila Vps8 is highly expressed in hemocytes and nephrocytes, and localizes to early endosomes despite the lack of a clear Vps3 homolog. We find that Vps8 forms a complex and acts together with Vps16A, Dor/Vps18 and Car/Vps33A, and loss of any of these proteins leads to fragmentation of endosomes. Surprisingly, Vps11 deletion causes enlargement of endosomes, similar to loss of the HOPS-specific subunits Vps39 and Lt/Vps41. We thus identify a 4 subunit-containing miniCORVET complex as an unconventional early endosomal tether in Drosophila. DOI: http://dx.doi.org/10.7554/eLife.14226.001 PMID:27253064
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Karan, Abraar; Amado, Vanda; Vitorino, Pio; Kulber, David; Taela, Atanasio; DeUgarte, Daniel
2015-01-01
Background Pediatric burn injuries are one of the leading causes of preventable morbidity and mortality in Sub-Saharan Africa. Research on the complex system of social, economic and cultural factors contributing to burn injuries in this setting is much needed. Methods We conducted a prospective questionnaire-based analysis of pediatric burn patients presenting to the Hospital Central de Maputo. A total of 39 patients were included in the study. Interviews were conducted with the children’s caretakers by two trained medical students at the Eduardo Mondlane Medical School in Maputo with the aid of local nursing staff. Results Most burns occurred from scald wounds (26/39) particularly from bathwater, followed by fire burns (11/39). Burns occurred more frequently in the afternoon (16/39) and evening (16/39). Over one quarter of burns (9/33) occurred in the absence of a caretaker. One third (12/36) of participants attempted to treat the burn at home prior to bringing the child in to the hospital, and roughly two-thirds (24/37) reported using traditional remedies for burn care. The average household had just 2 rooms for an average of 5 family members. Most burns were grade II (25/37). Conclusions Prevention efforts in this setting are much needed and can be implemented taking complex cultural and social factors into account. Education regarding regulation of water temperature for baths is important, given the prevalence of scald burns. Moreover, the introduction of low-cost, safer cooking technology can help mitigate inhalation injury and reduce fire burns. Additionally, burn care systems must be integrated with local traditional medical interventions to respect local cultural medicinal practices. PMID:26280740
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Kaminska, Izabela; Bohlen, Johann; Mackowski, Sebastian; Tinnefeld, Philip; Acuna, Guillermo P
2018-02-27
In this contribution, we fabricate hybrid constructs based on a natural light-harvesting complex, peridinin-chlorophyll a-protein, coupled to dimer optical antennas self-assembled with the help of the DNA origami technique. This approach enables controlled positioning of individual complexes at the hotspot of the optical antennas based on large, colloidal gold and silver nanoparticles. Our approach allows us to selectively excite the different pigments present in the harvesting complex, reaching a fluorescence enhancement of 500-fold. This work expands the range of self-assembled functional hybrid constructs for harvesting sunlight and can be further developed for other pigment-proteins and proteins.
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Designing Hyperchaotic Cat Maps With Any Desired Number of Positive Lyapunov Exponents.
Hua, Zhongyun; Yi, Shuang; Zhou, Yicong; Li, Chengqing; Wu, Yue
2018-02-01
Generating chaotic maps with expected dynamics of users is a challenging topic. Utilizing the inherent relation between the Lyapunov exponents (LEs) of the Cat map and its associated Cat matrix, this paper proposes a simple but efficient method to construct an -dimensional ( -D) hyperchaotic Cat map (HCM) with any desired number of positive LEs. The method first generates two basic -D Cat matrices iteratively and then constructs the final -D Cat matrix by performing similarity transformation on one basic -D Cat matrix by the other. Given any number of positive LEs, it can generate an -D HCM with desired hyperchaotic complexity. Two illustrative examples of -D HCMs were constructed to show the effectiveness of the proposed method, and to verify the inherent relation between the LEs and Cat matrix. Theoretical analysis proves that the parameter space of the generated HCM is very large. Performance evaluations show that, compared with existing methods, the proposed method can construct -D HCMs with lower computation complexity and their outputs demonstrate strong randomness and complex ergodicity.
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Electron Paramagnetic Resonance Spectroscopy of Vanadium (IV) Complexes and Related Species.
1980-07-27
Extensive near infrared (4000-650cm " ) investigations on VOCl 2 complexes have been made by many workers [21,39,43-49]. However the far infrared ...to facilitate the assignment of cation and ligand bacds. 4.2.1.2 Near Infrared Spectroscopy There are three principal reasons for measuriiio the... near infrared spectra of the co!;,plexes: (a) To establish the purity of the complex (b) To establish the bondi ng mode of the 1 i ( nd (c) To establish
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Endeavour, Orbiter Vehicle (OV) 105, roll out to KSC Launch Complex Pad 39B
1992-03-13
S92-34862 (13 March 1992) --- An otter, surprised by the unexpected presence of the photographer, seems unaware of the Space Shuttle Endeavour rolling behind it to Launch Pad 39B. Endeavour is the newest orbiter in the Shuttle fleet. Still ahead for Endeavour (OV-105) is a Flight Readiness Firing of its three main engines, and the Terminal Countdown Demonstration Test with the flight crew. Endeavour's maiden voyage on NASA's mission STS-49 will occur in late spring.
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FILMING OF 'CONTACT' AT LC39 PRESS SITE
NASA Technical Reports Server (NTRS)
1997-01-01
Warner Bros.' cast and crew are filming scenes for the movie 'Contact' at Kennedy Space Center's Launch Complex 39 Press Site on January 30. The screenplay for 'Contact' is based on the best- selling novel by the late astronomer Carl Sagan. The cast includes Jodie Foster, Matthew McConaughey, John Hurt, James Woods, Tom Skerritt, David Morse, William Fichtner, Rob Lowe and Angela Bassett. Described by Warner Bros. as a science fiction drama, 'Contact' will depict humankind's first encounter with evidence of extraterrestrial life.
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FILMING OF 'CONTACT' AT LC39 PRESS SITE
NASA Technical Reports Server (NTRS)
1997-01-01
Warner Bros.' cast and crew are filming scenes for the movie 'Contact' at Kennedy Space Center's Launch Complex 39 Press Site on January 29. The screenplay for 'Contact' is based on the best- selling novel by the late astronomer Carl Sagan. The cast includes Jodie Foster, Matthew McConaughey, John Hurt, James Woods, Tom Skerritt, David Morse, William Fichtner, Rob Lowe and Angela Bassett. Described by Warner Bros. as a science fiction drama, 'Contact' will depict humankind's first encounter with evidence of extraterrestrial life.
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Semelr, B.L.; Anderson, C.W.; Hanecak, R.
1982-02-01
A synthetic heptapeptide corresponding to the C-terminal sequence of the poliovirus genome protein (VPg) has been linked to bovine serum albumin and used to raise antibodies in rabbits. These antibodies precipitate not only VPg but also at least two more virus-specific polypeptides. The smaller polypeptide, denoted P3-9 (12,000 daltons), has been mapped by Edman degradation and by fragmentation with cyanogen bromide and determined to be the N-terminal cleavage product of polypeptide P3-1b, a precursor to the RNA polymerase. P3-9 contains the sequence of the basic protein VPg (22 amino acids) at its C terminus. As predicted by the known RNAmore » sequence of poliovirus, P3-9 also contains a hydrophobic region of 22 amino acids preceding VPg, an observation suggesting that P3-9 may be membrane-associated. This was confirmed by fractionation of infected cells in the presence or absence of detergent. We speculate that P3-9 may be the donor of VPg to RNA chains in the membrane-bound RNA replication complex.« less
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2009-09-25
Construction of the A-3 Test Stand approaches another milestone with delivery and installation of water, isopropyl alcohol (IPA) and liquid oxygen (LOX) tanks. The three LOX tanks shown on the left and the two IPA tanks shown on the right are all 35,000 gallons each. The four water tanks in the center are 39,000 gallons each.
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Aspects of the evolution of the West Antarctic margin of Gondwanaland
DOE Office of Scientific and Technical Information (OSTI.GOV)
Grunow, A.M.
1989-01-01
A combination of paleomagnetism, structural field mapping, microprobe analysis, microfabric analysis and {sup 40}Ar/{sup 39}Ar geochronology was used to elucidate the history of the West Antarctic crustal block and the evolution of subduction complexes along the Scotia Ridge. West Antarctica is composed of four crustal blocks whose relationship to East Antarctica and to each other throughout the Phanerozoic is not well known. These blocks are: the Ellsworth-Whitmore Mountains (EWM); the Antarctic Peninsula (AP); Thurston Island (TI); Marie Byrd Land (MBL). Paleomagnetic sampling and analysis were conducted on rocks from the EWM and TI blocks in the hope of constraining themore » motion of these blocks and the opening history of the Weddell Sea. The paleomagnetic results suggest that the AP, EWM, and TI blocks have moved relative to East Antarctica prior to the mid-Cretaceous and that the main opening of the Weddell Sea was between the Early and mid-Cretaceous. Detailed field mapping was conducted on the subduction complexes of the Scotia Metamorphic Complex (SMC) on Smith Island and Elephant Island (Antarctica). Polyphase ductile deformation characterizes the Smith Island and Elephant Island tectonites. Microprobe analyses indicate that the blue amphiboles from both areas are primary crossite. Pressure-temperature estimates for Smith Island blueschist metamorphism are {approximately}350 C at 6-7 kbars. The {sup 40}Ar/{sup 39}Ar geochronology indicates a complex thermal evolution for the SMC. The north to south increase in intensity of deformation and metamorphism on Elephant Island corresponds to decrease in {sup 40}Ar/{sup 39}Ar age. Uplift of the Smith Island blueschists occurred since 47 Ma while most of the uplift on Elephant Island occurred since {approximately}102 Ma.« less
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Crew Launch Vehicle Mobile Launcher Solid Rocket Motor Plume Induced Environment
NASA Technical Reports Server (NTRS)
Vu, Bruce T.; Sulyma, Peter
2008-01-01
The plume-induced environment created by the Ares 1 first stage, five-segment reusable solid rocket motor (RSRMV) will impose high heating rates and impact pressures on Launch Complex 39. The extremes of these environments pose a potential threat to weaken or even cause structural components to fail if insufficiently designed. Therefore the ability to accurately predict these environments is critical to assist in specifying structural design requirements to insure overall structural integrity and flight safety. This paper presents the predicted thermal and pressure environments induced by the launch of the Crew Launch Vehicle (CLV) from Launch Complex (LC) 39. Once the environments are predicted, a follow-on thermal analysis is required to determine the surface temperature response and the degradation rate of the materials. An example of structures responding to the plume-induced environment will be provided.
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NASA Technical Reports Server (NTRS)
Koller, A. M., Jr.; Knott, W. M.
1985-01-01
Near field and far field environmental monitoring activities extending from the first launch of the Space Shuttle at the Kennedy Space Center have provided a database from which conclusions can now be drawn for short term, acute effects of launch and, to a lesser degree, long term cumulative effects on the natural environment. Data for the first 15 launches of the Space Shuttle from Kennedy Space Center Pad 39A are analyzed for statistical significance and reduced to graphical presentations of individual and collective disposition isopleths, summarization of observed environmental impacts (e.g., vegetation damage, fish kills), and supporting data from specialized experiments and laboratory analyses. Conclusions are drawn with regard to the near field environment at Pad A, the effects on the lagoonal complex, and the relationships of these data and conclusions to upcoming operations at Complex 39 Pad B where the environment is significantly different. The paper concludes with a subjective evaluation of the likely impacts at Vandenberg Space Launch Complex 6 for the first Shuttle launch next year.
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STS-102 Pilot Kelly talks to media at Launch Pad 39B during TCDT
NASA Technical Reports Server (NTRS)
2001-01-01
KENNEDY SPACE CENTER, Fla. -- STS-102 Pilot James Kelly answers a question from the media during an interview session at the slidewire basket landing near Launch Pad 39B. He and other crew members are at KSC for Terminal Countdown Demonstration Test activities, which also include a simulated launch countdown. STS-102 is the eighth construction flight to the International Space Station, with Space Shuttle Discovery carrying the Multi-Purpose Logistics Module Leonardo. Discovery will also be transporting the Expedition Two crew to the Space Station, to replace Expedition One, who will return to Earth with Discovery. Launch on mission STS-102 is scheduled for March 8.
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STS-102 MS Richards talks to media at Launch Pad 39B during TCDT
NASA Technical Reports Server (NTRS)
2001-01-01
KENNEDY SPACE CENTER, Fla. -- STS-102 Mission Specialist Paul Richards answers a question from the media during an interview session at the slidewire basket landing near Launch Pad 39B. He and other crew members are at KSC for Terminal Countdown Demonstration Test activities, which also include a simulated launch countdown. STS-102 is the eighth construction flight to the International Space Station, with Space Shuttle Discovery carrying the Multi-Purpose Logistics Module Leonardo. Discovery will also be transporting the Expedition Two crew to the Space Station, to replace Expedition One, who will return to Earth with Discovery. Launch on mission STS-102 is scheduled for March 8.
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STS-102 MS Thomas talks to media at Launch Pad 39B during TCDT
NASA Technical Reports Server (NTRS)
2001-01-01
KENNEDY SPACE CENTER, Fla. -- STS-102 Mission Specialist Andrew Thomas answers a question from the media during an interview session at the slidewire basket landing near Launch Pad 39B. He and other crew members are at KSC for Terminal Countdown Demonstration Test activities, which also include a simulated launch countdown. STS-102 is the eighth construction flight to the International Space Station, with Space Shuttle Discovery carrying the Multi-Purpose Logistics Module Leonardo. Discovery will also be transporting the Expedition Two crew to the Space Station, to replace Expedition One, who will return to Earth with Discovery. Launch on mission STS-102 is scheduled for March 8.
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2009-01-22
CAPE CANAVERAL, Fla. – Brilliant beams of sunlight bounce off the new lightning tower under construction on Launch Pad 39B at NASA's Kennedy Space Center in Florida. New sections are being added with the help of a giant crane (at right). Three new lightning towers on the pad will be 500 feet tall with an additional 100-foot fiberglass mast atop supporting a wire catenary system. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Photo credit: NASA/Kim Shiflett
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2000-07-28
KENNEDY SPACE CENTER, FLA. -- During a visit to KSC, NASCAR race driver Jeff Gordon (left) looks at a tile in the Tile Shop in the Launch Complex 39 area. Former KSC launch director Bob Sieck (far right) looks on
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2000-07-28
KENNEDY SPACE CENTER, FLA. -- During a visit to KSC, NASCAR race driver Jeff Gordon (left) looks at a tile in the Tile Shop in the Launch Complex 39 area. Former KSC launch director Bob Sieck (far right) looks on
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A Study of Ship Acquisition Cost Estimating in the Naval Sea Systems Command. Appendices
1977-10-01
Shipbuilding Is A Heovy Fabrication Industry Pro- ducing Small Numbers Of Expensive, Complex Units Of Output PAGE A-2 (1) Due to its heavy ...estimate future ship construction costs. - A-l 1. SHIPBUILDING IS A HEAVY FABRICATION INDUSTRY PRODUCING SMALL NUMBERS OF EXPENSIVE, COMPLEX...extensively in production line industries such as automotive products and the airframe industry. (1) Due To Its Heavy Construction Orientation
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Perspectives of construction robots
NASA Astrophysics Data System (ADS)
Stepanov, M. A.; Gridchin, A. M.
2018-03-01
This article is an overview of construction robots features, based on formulating the list of requirements for different types of construction robots in relation to different types of construction works.. It describes a variety of construction works and ways to construct new or to adapt existing robot designs for a construction process. Also, it shows the prospects of AI-controlled machines, implementation of automated control systems and networks on construction sites. In the end, different ways to develop and improve, including ecological aspect, the construction process through the wide robotization, creating of data communication networks and, in perspective, establishing of fully AI-controlled construction complex are formulated.
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Pydna: a simulation and documentation tool for DNA assembly strategies using python.
Pereira, Filipa; Azevedo, Flávio; Carvalho, Ângela; Ribeiro, Gabriela F; Budde, Mark W; Johansson, Björn
2015-05-02
Recent advances in synthetic biology have provided tools to efficiently construct complex DNA molecules which are an important part of many molecular biology and biotechnology projects. The planning of such constructs has traditionally been done manually using a DNA sequence editor which becomes error-prone as scale and complexity of the construction increase. A human-readable formal description of cloning and assembly strategies, which also allows for automatic computer simulation and verification, would therefore be a valuable tool. We have developed pydna, an extensible, free and open source Python library for simulating basic molecular biology DNA unit operations such as restriction digestion, ligation, PCR, primer design, Gibson assembly and homologous recombination. A cloning strategy expressed as a pydna script provides a description that is complete, unambiguous and stable. Execution of the script automatically yields the sequence of the final molecule(s) and that of any intermediate constructs. Pydna has been designed to be understandable for biologists with limited programming skills by providing interfaces that are semantically similar to the description of molecular biology unit operations found in literature. Pydna simplifies both the planning and sharing of cloning strategies and is especially useful for complex or combinatorial DNA molecule construction. An important difference compared to existing tools with similar goals is the use of Python instead of a specifically constructed language, providing a simulation environment that is more flexible and extensible by the user.
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ERIC Educational Resources Information Center
Rodriguez, Walter; Opdenbosh, Augusto; Santamaria, Juan Carlos
2006-01-01
Visual information is vital in planning and managing construction operations, particularly, where there is complex terrain topography and salvage operations with limited accessibility and visibility. From visually-assessing site operations and preventing equipment collisions to simulating material handling activities to supervising remotes sites…
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Final Flame Trench Brick Installation at Launch Pad 39B
2017-05-09
A view of the north side of the flame trench at Launch Complex 39B at NASA's Kennedy Space Center in Florida. The final brick was installed in the flame trench, completing about a year's worth of work to upgrade the walls to withstand the intense heat and fire at launch of NASA's Space Launch System rocket with Orion atop. About 96,000 heat-resistant bricks, in three different sizes, were secured to the walls using bonding mortar in combination with adhesive anchors. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to Pad 39B to support the launch of the SLS and Orion spacecraft for Exploration Mission-1 and NASA’s journey to Mars.
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38 CFR 39.60 - General requirements for site selection and construction of veterans cemeteries.
Code of Federal Regulations, 2011 CFR
2011-07-01
... Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) AID TO STATES FOR ESTABLISHMENT, EXPANSION, AND IMPROVEMENT, OR OPERATION AND MAINTENANCE, OF VETERANS CEMETERIES Establishment, Expansion, and Improvement... criteria and shall apply to all Establishment, Expansion, and Improvement Projects for which Federal...
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38 CFR 39.15 - Amount of grant.
Code of Federal Regulations, 2010 CFR
2010-07-01
... STATES FOR ESTABLISHMENT, EXPANSION, AND IMPROVEMENT OF VETERANS' CEMETERIES (Eff. until 7-16-10) Award... grant, the cost of equipment necessary for the operation of the State cemetery. This may include the... operation of the State cemetery, but only if: (i) Included in the construction contract; (ii) Installed...
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DOE Office of Scientific and Technical Information (OSTI.GOV)
Dallmeyer, R.D.
1989-03-01
Hornblende concentrates prepared from cuttings from two deep test wells penetrating the complex display internally concordant {sup 40}Ar/{sup 39}Ar incremental-release spectra defining plateau ages of 510.8 {plus minus} 1.1 Ma and 513.1 {plus minus} 1.8 Ma, which are interpreted to date post-metamorphic cooling through temperatures required for intracrystalline argon retention. The Kasila Group constitutes the western segment of the Rokelide orogen in Sierra Leone. Four hornblende concentrations prepared for amphibolite within the Kasila Group yield {sup 40}Ar/{sup 39}Ar plateau ages of 505.0 {plus minus} 5.2, 508.2 {plus minus} 2.1, 510.5 {plus minus} 2.6, and 546.1 {plus minus} 6.8 Ma. Theymore » are interpreted to date post-metamorphic cooling through appropriate argon closure temperature following a ca. 550-560 Ma, Pan-African II phase of tectonothermal activity. A biotite concentrate from paragneiss within the Kasila Group displays an internally concordant {sup 40}/Ar{sup 39}Ar release spectrum defining a plateau age of 524.7 {plus minus} 1.3 Ma, which likely reflects slight contamination with extraneous (excess) argon. Muscovite from the Marampa Group yields a {sup 40}Ar/{sup 39}Ar plateau age of 561.1 {plus minus} 2.3 Ma, which is interpreted to date cooling through appropriate argon closure temperatures. Although these temperatures are generally considered to be lower than those for hornblenede, the muscovite records an older cooling age, suggesting that the Marampa Group experienced slightly earlier post-metamorphic uplift and cooling relative to the Kasila Group. Lithologic comparison combined with similarities in post-metamorphic thermal evolution suggest that the St. Lucie Metamorphic Complex originated within the Rockelide orogen. This and other lithotectonic elements of the Suwannee terrane appear to represent a fragment of Gondwana which accreted to Laurentia during late Paleozoic amalgamation of Pangea.« less
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Floodlights illuminate view of Skylab 3 vehicle at Pad B, Launch Complex 39
1973-07-20
S73-32568 (20 July 1973) --- Floodlights illuminate this nighttime view of the Skylab 3/Saturn 1B space vehicle at Pad B, Launch Complex 39, Kennedy Space Center, Florida, during prelaunch preparations. The reflection is the water adds to the scene. In addition to the Command/Service Module and its launch escapte system, the Skylab 3 space vehicle consists of the Saturn 1B first (S-1B) stage and the Saturn 1B second (S-IVB) stage. The crew for the scheduled 59-day Skylab 3 mission in Earth orbit will be astronauts Alan L. Bean, Owen K. Garriott and Jack R. Lousma. Skylab 3 was launched on July 28, 1973. Photo credit: NASA
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Li, Zhigang; Shi, Zhongping; Li, Xin
2014-05-01
Several fermentations with consecutively feeding of acetate/butyrate were conducted in a 7 L fermentor and the results indicated that exogenous acetate/butyrate enhanced solvents productivities by 47.1% and 39.2% respectively, and changed butyrate/acetate ratios greatly. Then extracellular butyrate/acetate ratios were utilized for calculation of acids rates and the results revealed that acetate and butyrate formation pathways were almost blocked by corresponding acids feeding. In addition, models for acetate/butyrate feeding fermentations were constructed by graph theory based on calculation results and relevant reports. Solvents concentrations and butanol/acetone ratios of these fermentations were also calculated and the results of models calculation matched fermentation data accurately which demonstrated that models were constructed in a reasonable way. Copyright © 2014 Elsevier Ltd. All rights reserved.
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ERIC Educational Resources Information Center
Jackson, Douglas N.
The term "conative" is used to describe constructs that span both motivational and volitional aspects of human behavior, distinguished from constructs that emphasize cognition and affection. Among the conative constructs are achievement strivings, beliefs about self-esteem and self-efficacy, interests and attitudes about learning,…
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Hudson, Christopher D.; Huxley, Jonathan N.; Green, Martin J.
2014-01-01
The ever-growing volume of data routinely collected and stored in everyday life presents researchers with a number of opportunities to gain insight and make predictions. This study aimed to demonstrate the usefulness in a specific clinical context of a simulation-based technique called probabilistic sensitivity analysis (PSA) in interpreting the results of a discrete time survival model based on a large dataset of routinely collected dairy herd management data. Data from 12,515 dairy cows (from 39 herds) were used to construct a multilevel discrete time survival model in which the outcome was the probability of a cow becoming pregnant during a given two day period of risk, and presence or absence of a recorded lameness event during various time frames relative to the risk period amongst the potential explanatory variables. A separate simulation model was then constructed to evaluate the wider clinical implications of the model results (i.e. the potential for a herd’s incidence rate of lameness to influence its overall reproductive performance) using PSA. Although the discrete time survival analysis revealed some relatively large associations between lameness events and risk of pregnancy (for example, occurrence of a lameness case within 14 days of a risk period was associated with a 25% reduction in the risk of the cow becoming pregnant during that risk period), PSA revealed that, when viewed in the context of a realistic clinical situation, a herd’s lameness incidence rate is highly unlikely to influence its overall reproductive performance to a meaningful extent in the vast majority of situations. Construction of a simulation model within a PSA framework proved to be a very useful additional step to aid contextualisation of the results from a discrete time survival model, especially where the research is designed to guide on-farm management decisions at population (i.e. herd) rather than individual level. PMID:25101997
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Hudson, Christopher D; Huxley, Jonathan N; Green, Martin J
2014-01-01
The ever-growing volume of data routinely collected and stored in everyday life presents researchers with a number of opportunities to gain insight and make predictions. This study aimed to demonstrate the usefulness in a specific clinical context of a simulation-based technique called probabilistic sensitivity analysis (PSA) in interpreting the results of a discrete time survival model based on a large dataset of routinely collected dairy herd management data. Data from 12,515 dairy cows (from 39 herds) were used to construct a multilevel discrete time survival model in which the outcome was the probability of a cow becoming pregnant during a given two day period of risk, and presence or absence of a recorded lameness event during various time frames relative to the risk period amongst the potential explanatory variables. A separate simulation model was then constructed to evaluate the wider clinical implications of the model results (i.e. the potential for a herd's incidence rate of lameness to influence its overall reproductive performance) using PSA. Although the discrete time survival analysis revealed some relatively large associations between lameness events and risk of pregnancy (for example, occurrence of a lameness case within 14 days of a risk period was associated with a 25% reduction in the risk of the cow becoming pregnant during that risk period), PSA revealed that, when viewed in the context of a realistic clinical situation, a herd's lameness incidence rate is highly unlikely to influence its overall reproductive performance to a meaningful extent in the vast majority of situations. Construction of a simulation model within a PSA framework proved to be a very useful additional step to aid contextualisation of the results from a discrete time survival model, especially where the research is designed to guide on-farm management decisions at population (i.e. herd) rather than individual level.
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NASA Astrophysics Data System (ADS)
Siddiqui, Talha S.
Magnetic resonance imaging (MRI) is a non-invasive method for imaging and diagnosing tissue damage, organ function and the vascular system. Magnevist(TM) a complex of diethylenetriaminepentaacetic acid (DTPA) and Gd3+ is a clinically approved contrast agent for MRI. A derivative of DTPA was formed by the addition of two cysteine groups (DTPA-L-Cys) through amide linkage. The Gd complex of this ligand bonds with the silver surfaces through the cysteine thiols. GdDTPA-L-Cys was bound to ˜10nm diameter Ag nanoparticles for use as a multifunctional MRI contrast agent. The ligand and complex were characterized by 1H and 13C NMR, ESI-MS and IR spectroscopy. The silver construct was characterized by TEM, TGA and UV-Vis absorption spectra. The per metal complex r1 relaxivity of GdDTPA-L-Cys{Ag} greater than that of Magnavist(TM) with the same molarity for both compounds. The synthesis of a DTPA derivative is described that allows it to bind to silver or gold nanoparticles through a single thiol linkage (DTPASH). The resulting Gd complex, GdDTPASH, was bound to Ag nanoparticles to create a single monolayer on the surface. The construct was further stabilized in buffered solution with the addition of a thiolated PEG chain. The highly stabilized nanoparticle construct delivers a high payload of Gd compelex and is an effective T1 brightening agent. The production of this type of construct opens the way for engineered multimodal MRI contrast agents.
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2011-12-19
CAPE CANAVERAL, Fla. -- A brown pelican stands sentinel on a piling in the turn basin at NASA Kennedy Space Center's Launch Complex 39. Launch Pad 39A is visible in the background. The center shares a boundary with the Merritt Island National Wildlife Refuge, consisting of 140,000 acres. The refuge provides a wide variety of habitats -- coastal dunes, saltwater estuaries and marshes, freshwater impoundments, scrub, pine flatwoods, and hardwood hammocks -- that provide sanctuary for more than 1,500 species of plants and animals, including about 331 species of birds. Photo credit: NASA/Jim Grossmann
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Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer.
Dennis, Sarah Grace; Trusk, Thomas; Richards, Dylan; Jia, Jia; Tan, Yu; Mei, Ying; Fann, Stephen; Markwald, Roger; Yost, Michael
2015-09-22
Tissue engineering has centralized its focus on the construction of replacements for non-functional or damaged tissue. The utilization of three-dimensional bioprinting in tissue engineering has generated new methods for the printing of cells and matrix to fabricate biomimetic tissue constructs. The solid freeform fabrication (SFF) method developed for three-dimensional bioprinting uses an additive manufacturing approach by depositing droplets of cells and hydrogels in a layer-by-layer fashion. Bioprinting fabrication is dependent on the specific placement of biological materials into three-dimensional architectures, and the printed constructs should closely mimic the complex organization of cells and extracellular matrices in native tissue. This paper highlights the use of the Palmetto Printer, a Cartesian bioprinter, as well as the process of producing spatially organized, viable constructs while simultaneously allowing control of environmental factors. This methodology utilizes computer-aided design and computer-aided manufacturing to produce these specific and complex geometries. Finally, this approach allows for the reproducible production of fabricated constructs optimized by controllable printing parameters.
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Construction continues on RLV Support Complex at SLF
NASA Technical Reports Server (NTRS)
1999-01-01
An aerial view reveals (foreground) the ongoing construction of an $8 million Reusable Launch Vehicle (RLV) Support Complex at Kennedy Space Center. At left is a multi-purpose hangar and at right a building for related ground support equipment and administrative/ technical support. In the background is the Vehicle Assembly Building. The road at right is the tow-way. The RLV complex will be available to accommodate the Space Shuttle; the X-34 RLV technology demonstrator; the L-1011 carrier aircraft for Pegasus and X-34; and other RLV and X-vehicle programs. The complex is jointly funded by the Spaceport Florida Authority, NASA's Space Shuttle Program and KSC. The facility will be operational in early 2000.
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2017-02-19
A SpaceX Falcon 9 rocket lifts off from Launch Complex 39A at NASA's Kenney Space Center in Florida. This is the company's 10th commercial resupply services mission to the International Space Station. Liftoff was at 9:39 a.m. EST from the historic launch site now operated by SpaceX under a property agreement with NASA. The Dragon spacecraft will deliver about 5,500 pounds of supplies to the space station, including the Stratospheric Aerosol and Gas Experiment (SAGE) III instrument to further study ozone in the atmosphere.
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ERIC Educational Resources Information Center
Nikolaeva, Sardana
2013-01-01
The South African coloured identity is a profoundly complex construction that, on the one hand, is interpreted as an ambiguous and "in-between" identity and, on the other hand, its own ambiguity and complexity provides multiple means and strategies of production and articulation within various contexts. This dissertation seeks to examine…
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González Montoro, Ayelén; Auffarth, Kathrin; Hönscher, Carina; Bohnert, Maria; Becker, Thomas; Warscheid, Bettina; Reggiori, Fulvio; van der Laan, Martin; Fröhlich, Florian; Ungermann, Christian
2018-06-04
The extensive subcellular network of membrane contact sites plays central roles in organelle biogenesis and communication, yet the precise contributions of the involved machineries remain largely enigmatic. The yeast vacuole forms a membrane contact site with mitochondria, called vacuolar and mitochondrial patch (vCLAMP). Formation of vCLAMPs involves the vacuolar Rab GTPase Ypt7 and the Ypt7-interacting Vps39 subunit of the HOPS tethering complex. Here, we uncover the general preprotein translocase of the outer membrane (TOM) subunit Tom40 as the direct binding partner of Vps39 on mitochondria. We identify Vps39 mutants defective in TOM binding, but functional for HOPS. Cells that cannot form vCLAMPs show reduced growth under stress conditions and impaired survival upon starvation. Unexpectedly, our mutant analysis revealed the existence of two functionally independent vacuole-mitochondria MCSs: one formed by the Ypt7-Vps39-Tom40 tether and a second one by Vps13-Mcp1, which is redundant with ER-mitochondrial contacts formed by ERMES. Copyright © 2018 Elsevier Inc. All rights reserved.
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Forsythe, Alex; Street, Nichola; Helmy, Mai
2017-08-01
Differences between norm ratings collected when participants are asked to consider more than one picture characteristic are contrasted with the traditional methodological approaches of collecting ratings separately for image constructs. We present data that suggest that reporting normative data, based on methodological procedures that ask participants to consider multiple image constructs simultaneously, could potentially confounded norm data. We provide data for two new image constructs, beauty and the extent to which participants encountered the stimuli in their everyday lives. Analysis of this data suggests that familiarity and encounter are tapping different image constructs. The extent to which an observer encounters an object predicts human judgments of visual complexity. Encountering an image was also found to be an important predictor of beauty, but familiarity with that image was not. Taken together, these results suggest that continuing to collect complexity measures from human judgments is a pointless exercise. Automated measures are more reliable and valid measures, which are demonstrated here as predicting human preferences.
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Steel Erection Safety. Module SH-39. Safety and Health.
ERIC Educational Resources Information Center
Center for Occupational Research and Development, Inc., Waco, TX.
This student module on steel erection safety is one of 50 modules concerned with job safety and health. This module identifies typical jobsite hazards encountered by steel erectors, as well as providing safe job procedures for general and specific construction activities. Following the introduction, 11 objectives (each keyed to a page in the text)…
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Equal Opportunity in the Classroom: Test Construction in a Diversity-Sensitive Environment.
ERIC Educational Resources Information Center
Ghorpade, Jai; Lackritz, James R.
1998-01-01
Two multiple-choice tests and one essay test were taken by 231 students (50/50 male/female, 192 White, 39 East Asian, Black, Mexican American, or Middle Eastern). Multiple-choice tests showed no significant differences in equal employment opportunity terms; women and men scored about the same on essays, but minority students had significantly…