STS-28 Columbia, OV-102, lifts off from KSC Launch Complex LC Pad 39B

NASA Image and Video Library

1989-08-08

STS028-S-006 (8 Aug 1989) --- A low-angle view shows Columbia soaring toward space just after clearing the tower at Launch Pad 39-B for the STS-28 mission. The spacecraft renews flight after a period of three and a half years, this time with five crewmembers aboard. Onboard the spacecraft are Astronauts Brewster H. Shaw Jr., Richard N. Richards, David C. Leestma, James C. Adamson and Mark N. Brown. The last time Columbia was in space was in January of 1986.

Triggered-Lightning Interaction with a Lightning Protective System: Current Distribution and Electromagnetic Environment

NASA Technical Reports Server (NTRS)

Mata, C. T.; Rakov, V. A.; Mata, A. G.

2010-01-01

A new comprehensive lightning instrumentation system has been designed for Launch Complex 39B (LC3913) at the Kennedy Space Center, Florida. This new instrumentation system includes the synchronized recording of six high-speed video cameras; currents through the nine downconductors of the new lightning protection system for LC3913; four dH/dt, 3-axis measurement stations; and five dE/dt stations composed of two antennas each. A 20:1 scaled down model of the new Lightning Protection System (LPS) of LC39B was built at the International Center for Lightning Research and Testing, Camp Blanding, FL. This scaled down lightning protection system was instrumented with the transient recorders, digitizers, and sensors to be used in the final instrumentation installation at LC3913. The instrumentation used at the ICLRT is also a scaled-down instrumentation of the LC39B instrumentation. The scaled-down LPS was subjected to seven direct lightning strikes and six (four triggered and two natural nearby flashes) in 2010. The following measurements were acquired at the ICLRT: currents through the nine downconductors; two dl-/dt, 3-axis stations, one at the center of the LPS (underneath the catenary wires), and another 40 meters south from the center of the LPS; ten dE/dt stations, nine of them on the perimeter of the LPS and one at the center of the LPS (underneath the catenary wire system); and the incident current. Data from representative events are presented and analyzed in this paper.

Numerical Modeling of Propellant Boil-Off in a Cryogenic Storage Tank

NASA Technical Reports Server (NTRS)

Majumdar, A. K.; Steadman, T. E.; Maroney, J. L.; Sass, J. P.; Fesmire, J. E.

2007-01-01

A numerical model to predict boil-off of stored propellant in large spherical cryogenic tanks has been developed. Accurate prediction of tank boil-off rates for different thermal insulation systems was the goal of this collaboration effort. The Generalized Fluid System Simulation Program, integrating flow analysis and conjugate heat transfer for solving complex fluid system problems, was used to create the model. Calculation of tank boil-off rate requires simultaneous simulation of heat transfer processes among liquid propellant, vapor ullage space, and tank structure. The reference tank for the boil-off model was the 850,000 gallon liquid hydrogen tank at Launch Complex 39B (LC- 39B) at Kennedy Space Center, which is under study for future infrastructure improvements to support the Constellation program. The methodology employed in the numerical model was validated using a sub-scale model and tank. Experimental test data from a 1/15th scale version of the LC-39B tank using both liquid hydrogen and liquid nitrogen were used to anchor the analytical predictions of the sub-scale model. Favorable correlations between sub-scale model and experimental test data have provided confidence in full-scale tank boil-off predictions. These methods are now being used in the preliminary design for other cases including future launch vehicles

The Quality Control Algorithms Used in the Process of Creating the NASA Kennedy Space Center Lightning Protection System Towers Meteorological Database

NASA Technical Reports Server (NTRS)

Orcutt, John M.; Brenton, James C.

2016-01-01

The methodology and the results of the quality control (QC) process of the meteorological data from the Lightning Protection System (LPS) towers located at Kennedy Space Center (KSC) launch complex 39B (LC-39B) are documented in this paper. Meteorological data are used to design a launch vehicle, determine operational constraints, and to apply defined constraints on day-of-launch (DOL). In order to properly accomplish these tasks, a representative climatological database of meteorological records is needed because the database needs to represent the climate the vehicle will encounter. Numerous meteorological measurement towers exist at KSC; however, the engineering tasks need measurements at specific heights, some of which can only be provided by a few towers. Other than the LPS towers, Tower 313 is the only tower that provides observations up to 150 m. This tower is located approximately 3.5 km from LC-39B. In addition, data need to be QC'ed to remove erroneous reports that could pollute the results of an engineering analysis, mislead the development of operational constraints, or provide a false image of the atmosphere at the tower's location.

Summary of 2011 Direct and Nearby Lightning Strikes to Launch Complex 39B, Kennedy Space Center, Florida

NASA Technical Reports Server (NTRS)

Mata, C.T.; Mata, A.G.

2012-01-01

A Lightning Protection System (LPS) was designed and built at Launch Complex 39B (LC39B), at the Kennedy Space Center (KSC), Florida in 2009. This LPS was instrumented with comprehensive meteorological and lightning data acquisition systems that were deployed from late 2010 until mid 2011. The first direct strikes to the LPS were recorded in March of 2011, when a limited number of sensors had been activated. The lightning instrumentation system detected a total of 70 nearby strokes and 19 direct strokes to the LPS, 2 of the 19 direct strokes to the LPS had two simultaneous ground attachment points (in both instances one channel terminated on the LPS and the other on the nearby ground). Additionally, there are more unaccounted nearby strokes seen on video records for which limited data was acquired either due to the distance of the stroke or the settings of the data acquisition system. Instrumentation deployment chronological milestones, a summary of lightning strikes (direct and nearby), high speed video frames, downconductor currents, and dH/dt and dE/dt typical waveforms for direct and nearby strokes are presented.

Shuttle Atlantis travels to LC-39B for STS-76

NASA Technical Reports Server (NTRS)

1996-01-01

The Space Shuttle Atlantis completes the journey to Launch Pad 39B from the Vehicle Assembly Building. Atlantis is being prepared for a March 21 liftoff on Mission STS-76, which will be highlighted by the third docking between the U.S. Shuttle and the Russian Space Station Mir and the transfer of U.S. astronaut Shannon Lucid to the station for an extended stay.

Toxic effect and genotoxicity of the semisynthetic derivatives dillapiole ethyl ether and dillapiole n-butyl ether for control of Aedes albopictus (Diptera: Culicidae).

PubMed

da Fonseca Meireles, Sabrina; Domingos, Pedro Rauel Cândido; da Silva Pinto, Ana Cristina; Rafael, Míriam Silva

2016-09-01

Two derivatives of dillapiole, dillapiole ethyl ether (1KL39-B) and butyl ether-n dillapiole (1KL43-C), were studied for their toxicity and genotoxicity against Aedes albopictus, to help develop new strategies for the control of this potential vector of dengue and other arboviruses, because it is resistant to synthetic insecticides. Eggs and larvae exposed to different concentrations of 1KL39-B (25, 30, 50, 70, and 80μg/mL) and of 1KL43-C (12.5, 20, 25, 30 and 40μg/mL) exhibited toxicity and susceptibility, with 100% mortality. The LC50 was 55.86±1.57μg/mL for 1KL39-B and 25.60±1.24μg/mL for 1KL43-C, while the LC90 was 70.12μg/mL for 1KL39-B and 41.51μg/mL for 1KL43-C. The gradual decrease in oviposition of the females of the G1 to G4 generations was proportional to the increase in concentrations of these compounds, which could be related to the cumulative effect of cell anomalies in neuroblasts and oocytes (P<0.05), including micronuclei, budding, multinucleated cells and nuclear bridges. These findings showed that both 1KL39-B and 1KL43-C can serve as potential alternatives in the control of A. albopictus. Copyright © 2016. Published by Elsevier B.V.

Launch Complex 39 Observation Gantry Area (SWMU# 107) Annual Long-Term Monitoring Report (Year 1) Kennedy Space Center, Florida

NASA Technical Reports Server (NTRS)

Johnson, Jill W.; Towns, Crystal

2015-01-01

This document has been prepared by Geosyntec Consultants, Inc. (Geosyntec) to present and discuss the findings of the 2014 and 2015 Long-Term Monitoring (LTM) activities that were completed at the Launch Complex 39 (LC39) Observation Gantry Area (OGA) located at the John F. Kennedy Space Center (KSC), Florida (Site). The remainder of this report includes: (i) a description of the Site location; (ii) summary of Site background and previous investigations; (iii) description of field activities completed as part of the annual LTM program at the Site; (iv) groundwater flow evaluation; (v) presentation and discussion of field and analytical results; and (vi) conclusions and recommendations. Applicable KSC Remediation Team (KSCRT) Meeting minutes are included in Attachment A. This Annual LTM Letter Report was prepared by Geosyntec Consultants (Geosyntec) for NASA under contract number NNK12CA13B, Delivery Order NNK13CA39T project number PCN ENV2188.

Aerial view of STS-33 Discovery, OV-103, lifting off from KSC LC Pad 39B

NASA Image and Video Library

1989-11-22

STS033-S-001 (22 Nov 1989) --- Lighting up the entire launch complex, the Space Shuttle Discovery heads toward an earth-orbital mission, devoted to the Department of Defense. Launch occurred at 7:23:29.989 p.m. (EST), November 22, 1989. The photograph was taken by Astronaut Michael L. Coats in the Shuttle Training Aircraft (STA).

STS-34 Commander Williams in KSC O and C Bldg prepares for TCDT activities

NASA Technical Reports Server (NTRS)

1989-01-01

STS-34 Commander Donald E. Williams is assisted by technicians with donning his launch and entry suit (LES) in the Kennedy Space Center (KSC) Operations and Checkout (O and C) Building prior to leaving for Launch Complex (LC) Pad 39B during terminal countdown demonstration test (TCDT) activities. Williams also catches a few minutes of relaxation while reclining in his chair.

Vps33b pathogenic mutations preferentially affect VIPAS39/SPE-39-positive endosomes.

PubMed

Tornieri, Karine; Zlatic, Stephanie A; Mullin, Ariana P; Werner, Erica; Harrison, Robert; L'hernault, Steven W; Faundez, Victor

2013-12-20

Mutations in Vps33 isoforms cause pigment dilution in mice (Vps33a, buff) and Drosophila (car) and the neurogenic arthrogryposis, renal dysfunction and cholestasis syndrome in humans (ARC1, VPS33B). The later disease is also caused by mutations in VIPAS39, (Vps33b interacting protein, apical-basolateral polarity regulator, SPE-39 homolog; ARC2), a protein that interacts with the HOmotypic fusion and Protein Sorting (HOPS) complex, a tether necessary for endosome-lysosome traffic. These syndromes offer insight into fundamental endosome traffic processes unique to metazoans. However, the molecular and cellular mechanisms underlying these mutant phenotypes remain poorly understood. Here we investigate interactions of wild-type and disease-causing mutations in VIPAS39/SPE-39 and Vps33b by yeast two hybrid, immunoprecipitation and quantitative fluorescent microscopy. We find that although few mutations prevent interaction between VIPAS39/SPE-39 and Vps33b, some mutants fragment VIPAS39/SPE-39-positive endosomes, but all mutants alter the subcellular localization of Vps33b to VIPAS39/SPE-39-positive endosomes. Our data suggest that the ARC syndrome may result through impaired VIPAS39/SPE-39 and Vps33b-dependent endosomal maturation or fusion.

KSC-2012-1860

NASA Image and Video Library

2012-02-17

Launch Complex 39 Construction: Launch Complex 39 LC-39 was originally designed and built to launch American astronauts toward the moon. The complex stretches inland from the Atlantic Ocean across four miles of what, until 1963, was a land of intermittent marshes and sandy scrub growth. In less than four years, starting with 1963 and ending with 1966, it was transformed into an operational spaceport embodying a mobile concept: rockets and spacecraft are erected in one area and transported to a separate location for launch. A total of 153 vehicles have been launched from LC-39. Poster designed by Kennedy Space Center Graphics Department/Greg Lee. Credit: NASA

STS-28 Columbia, Orbiter Vehicle (OV) 102, lifts off from KSC LC Pad 39B

NASA Image and Video Library

1989-08-08

STS028-S-007 (8 Aug 1989) --- Columbia is pictured just prior to clearing the tower at Launch Pad 39-B. The spacecraft renews flight after a period of three and a half years, this time with five crewmembers aboard for STS-28. Onboard the spacecraft are Astronauts Brewster H. Shaw Jr., Richard N. Richards, David C. Leestma, James C. Adamson and Mark N. Brown. The last time Columbia was in space was in January of 1986.

KSC Aerial Photos SI

NASA Image and Video Library

2016-11-28

KSC Aerial Photos; 00;00;12;00-00;00;28;50 VAB 00;00;28;50 -00;02;11;55 Pad 39B 00;02;11;55 -00;02;31;13 Sand Dunes/Beach 00;02;31;13-00;03;41;33 Pad 39A SpaceX 00;03;41;33-00;04;41;45 LC-41 ULA 00;04;41;45-00;05;54;40 NASA KSC Headquarters 00;05;54;40-00;07;18;00 KSC Industrial Area; Center Contact - Gregory B. Harland (321) 867-2468

Aerial view of the newest bus stop to view Launch Pad 39B

NASA Technical Reports Server (NTRS)

1998-01-01

Tour buses unload passengers at a new stop on the KSC tour that allows visitors to view Pad LC-39B. The tour road runs parallel to the crawlerway (just out of sight) that is used to transport the Space Shuttle vehicles to the pad. The length of the crawlerway from the Vehicle Assembly Building to Pad B is 6,828 meters (22,440 ft); its width overall is 40 meters (130 ft); each lane is 12 meters (40ft) with a 15-meter (50ft) median. This view looks south.

Aerial view of Launch Complex 39

NASA Technical Reports Server (NTRS)

1998-01-01

In this aerial view looking south can be seen Launch Complex (LC) 39 area, where assembly, checkout and launch of the Space Shuttle Orbiter and its External Tank and twin Solid Rocket Boosters take place. Central to the complex is the tallest building at the center, the Vehicle Assembly Building (VAB). To the immediate left, from top to bottom, are the Orbiter Processing Facility (OPF) High Bay 3 and new engine shop (north side), OPF Modular Office Building, Thermal Protection System Facility, and a crawler-transporter (to its left). In front of the VAB are OPF 1 and OPF 2. At right is the Processing Control Center. West of OPF 3 is the Mobile Launch Platform. In the upper left corner is Launch Pad B; at the far right is the turn basin, with the Press Site located just below it to the right.

STS-87 Columbia rolls out to LC 39B in preparation for launch

NASA Technical Reports Server (NTRS)

1997-01-01

The orbiter Columbia, mated to its external tank and two solid rocket boosters, is prepared to roll out of Kennedy Space Centers (KSCs) Vehicle Assembly Building (VAB) to Pad 39-B. Columbia is scheduled to launch on Nov. 19 for STS-87 on a 16-day flight of the United States Microgravity Payload (USMP)-4 mission. This mission also features the deployment and retrieval of the Spartan-201 satellite and a spacewalk to demonstrate assembly and maintenance operations for future use on the International Space Station.

The Quality Control Algorithms Used in the Creation of NASA Kennedy Space Center Lightning Protection System Towers Meteorological Database

NASA Technical Reports Server (NTRS)

Orcutt, John M.; Brenton, James C.

2016-01-01

An accurate database of meteorological data is essential for designing any aerospace vehicle and for preparing launch commit criteria. Meteorological instrumentation were recently placed on the three Lightning Protection System (LPS) towers at Kennedy Space Center (KSC) launch complex 39B (LC-39B), which provide a unique meteorological dataset existing at the launch complex over an extensive altitude range. Data records of temperature, dew point, relative humidity, wind speed, and wind direction are produced at 40, 78, 116, and 139 m at each tower. The Marshall Space Flight Center Natural Environments Branch (EV44) received an archive that consists of one-minute averaged measurements for the period of record of January 2011 - April 2015. However, before the received database could be used EV44 needed to remove any erroneous data from within the database through a comprehensive quality control (QC) process. The QC process applied to the LPS towers' meteorological data is similar to other QC processes developed by EV44, which were used in the creation of meteorological databases for other towers at KSC. The QC process utilized in this study has been modified specifically for use with the LPS tower database. The QC process first includes a check of each individual sensor. This check includes removing any unrealistic data and checking the temporal consistency of each variable. Next, data from all three sensors at each height are checked against each other, checked against climatology, and checked for sensors that erroneously report a constant value. Then, a vertical consistency check of each variable at each tower is completed. Last, the upwind sensor at each level is selected to minimize the influence of the towers and other structures at LC-39B on the measurements. The selection process for the upwind sensor implemented a study of tower-induced turbulence. This paper describes in detail the QC process, QC results, and the attributes of the LPS towers meteorological database.

STS-34 Atlantis, Orbiter Vehicle (OV) 104, lifts off from KSC LC Pad 39B

NASA Image and Video Library

1989-10-18

STS034-S-025 (18 Oct 1989) --- The STS-34 Space Shuttle Atlantis lifts off from Launch Pad 39-B at 2:53:39:983 p.m. (EDT), marking the beginning of a five-day mission in space. Atlantis carries a crew of five and the spacecraft Galileo, along with a number of other scientific experiments. The Jupiter-bound probe will be deployed from Atlantis some six hours after launch. The journey to the giant planet is expected to take over six years. Crewmembers for the mission are astronauts Donald E. Williams, Michael J. McCulley, Shannon W. Lucid, Franklin R. Chang-Diaz and Ellen S. Baker. The scene was recorded with a 70mm camera.

KSC-2014-2101

NASA Image and Video Library

2014-04-14

CAPE CANAVERAL, Fla. -- At Kennedy Space Center's Launch Pad 39A, Gwynne Shotwell, president and chief operating officer of Space Exploration Technologies SpaceX of Hawthorne, Calif., announces that NASA has just signed a lease agreement with SpaceX for use and operation of Launch Complex 39A. SpaceX will use Launch Complex 39A for rockets such as the Falcon Heavy, currently under development. Both launch pad 39A and 39B were originally built for the Apollo/Saturn V rockets that launched American astronauts on their historic journeys to the moon and later modified to support the 30-year shuttle program. Pad 39B is now being modified by NASA to support the Space Launch System SLS rocket boosting the Orion spacecraft part of the agency’s plan to explore beyond low-Earth orbit. To learn more about Launch Pad 39A visit: http://www.nasa.gov/mission_pages/shuttle/launch/launch-complex39-toc.html Photo credit: NASA/Dan Casper

KSC-2014-2100

NASA Image and Video Library

2014-04-14

CAPE CANAVERAL, Fla. -- At Kennedy Space Center Launch Pad 39A, NASA Administrator Charlie Bolden announces that NASA has just signed a lease agreement with Space Exploration Technologies SpaceX of Hawthorne, Calif., for use and operation of Launch Complex 39A. SpaceX will use Launch Complex 39A for rockets such as the Falcon Heavy, currently under development. Both launch pad 39A and 39B were originally built for the Apollo/Saturn V rockets that launched American astronauts on their historic journeys to the moon and later modified to support the 30-year shuttle program. Pad 39B is now being modified by NASA to support the Space Launch System SLS rocket boosting the Orion spacecraft part of the agency’s plan to explore beyond low-Earth orbit. To learn more about Launch Pad 39A visit: http://www.nasa.gov/mission_pages/shuttle/launch/launch-complex39-toc.html Photo credit: NASA/Dan Casper

KSC-2014-2099

NASA Image and Video Library

2014-04-14

CAPE CANAVERAL, Fla. -- At Kennedy Space Center Launch Pad 39A, NASA Administrator Charlie Bolden announces that NASA has just signed a lease agreement with Space Exploration Technologies SpaceX of Hawthorne, Calif., for use and operation of Launch Complex 39A. SpaceX will use Launch Complex 39A for rockets such as the Falcon Heavy, currently under development. Both launch pad 39A and 39B were originally built for the Apollo/Saturn V rockets that launched American astronauts on their historic journeys to the moon and later modified to support the 30-year shuttle program. Pad 39B is now being modified by NASA to support the Space Launch System SLS rocket boosting the Orion spacecraft part of the agency’s plan to explore beyond low-Earth orbit. To learn more about Launch Pad 39A visit: http://www.nasa.gov/mission_pages/shuttle/launch/launch-complex39-toc.html Photo credit: NASA/Dan Casper

STS-57 Endeavour, Orbiter Vehicle (OV) 105, lifts off from KSC LC Pad 39B

NASA Image and Video Library

1993-06-21

STS057-S-053 (21 June 1993) --- The Space Shuttle Endeavour lifts off Launch Pad 39B as captured on film by an audio-activated camera positioned at the 270-feet level on the Rotating Service Structure (RSS) at Launch Pad 39B. STS-57 launch occurred at 9:07:22 a.m. (EDT), June 21, 1993. The mission represents the first flight of the commercially developed SpaceHab laboratory module and also will feature a retrieval of the European Retrievable Carrier (EURECA). Onboard for Endeavour's fourth flight are a crew of six NASA astronauts; Ronald J. Grabe, mission commander; Brian Duffy, pilot; G. David Low, payload commander; and Nancy J. Sherlock, Peter J. K. (Jeff) Wisoff and Janice E. Voss, all mission specialists. An earlier launch attempt was scrubbed due to unacceptable weather conditions both at the Kennedy Space Center (KSC) and the overseas contingency landing sites.

STS-112 Atlantis Launch from LC-39B

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- Space Shuttle Atlantis leaps from the steam and smoke billowing across Launch Pad 39B after an on-time liftoff of 3:46 p.m. EDT on mission STS-112. Along with a crew of six, Atlantis carries the S1 Integrated Truss Structure and the Crew and Equipment Translation Aid (CETA) Cart A. The CETA is the first of two human-powered carts that will ride along the ISS railway, providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss. [Photo courtesy of Scott Andrews

STS-112 Atlantis Launch from LC-39B

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. - -- Space Shuttle Atlantis races toward space just after liftoff from Launch Pad 39B on mission STS-112. Liftoff occurred on time at 3:46 p.m. EDT. Along with a crew of six, Atlantis carries the S1 Integrated Truss Structure and the Crew and Equipment Translation Aid (CETA) Cart A to the International Space Station (ISS). The CETA is the first of two human-powered carts that will ride along the ISS railway, providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss.

STS-49 Endeavour, Orbiter Vehicle (OV) 105, lifts off from KSC LC Pad 39B

NASA Image and Video Library

1992-05-07

STS049-S-251 (7 May 1992) --- The Space Shuttle Endeavour soars toward Earth orbit where a crew of seven NASA astronauts will spend at least a week. Endeavour, the newest orbiter in NASA's Space Shuttle fleet, lifted off from Pad 39B at 7:40 p.m. (EDT), May 7, 1992. A diamond shock effect can be seen beneath the three main engines. Onboard are astronauts Daniel C. Brandenstein, mission commander; Kevin P. Chilton, pilot; and Richard J. Hieb, Bruce E. Melnick, Pierre J. Thuot, Kathryn C. Thornton and Thomas D. Akers, all mission specialists.

STS-87 Mission Specialist Doi and his wife pose at LC 39B

NASA Technical Reports Server (NTRS)

1997-01-01

STS-87 Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan poses with his wife, Hitomi Doi, in front of Kennedy Space Center's Launch Pad 39B during final prelaunch activities leading up to the scheduled Nov. 19 liftoff. The other STS-87 crew members are Commander Kevin Kregel; Pilot Steven Lindsey; Mission Specialists Kalpana Chawla, Ph.D., and Winston Scott; and Payload Specialist Leonid Kadenyuk of the National Space Agency of Ukraine. STS-87 will be the fourth flight of the United States Microgravity Payload and the Spartan- 201 deployable satellite.

Air-to-air view of STS-26 Discovery, OV-103, launch from KSC

NASA Technical Reports Server (NTRS)

1988-01-01

Air-to-air view of STS-26 Discovery, Orbiter Vehicle (OV) 103, launch taken by T. Haydee Laguna, an airline passenger bound for Paradise Island in the Bahamas. She sent the photo of what she called 'the most beautiful sight this side of Heaven' to NASA along with a congratulatory letter. OV-103 is a small dot as it rises through the clouds from Kennedy Space Center Launch Complex (LC) pad 39B with a exhaust plume trailing behind it.

STS-28 Columbia, OV-102, lifts off from KSC Launch Complex (LC) Pad 39B

NASA Image and Video Library

1989-08-08

STS028-S-008 (8 Aug 1989) --- A side view shows Columbia clearing the launch tower during the STS-28 liftoff. Columbia renews spaceflight after a period of three and a half years, this time with five crewmembers aboard for a DOD-devoted mission. Onboard the spacecraft are Astronauts Brewster H. Shaw Jr., Richard N. Richards, David C. Leestma, James C. Adamson and Mark N. Brown. The last time Columbia was in space was in January of 1986.

Launch Complex 39A, SWMU 008, Operations, Maintenance, and Monitoring Report, Kennedy Space Center, FL

NASA Technical Reports Server (NTRS)

Wilson, Deborah M.

2016-01-01

This Operations, Maintenance, and Monitoring Report (OMMR) presents the findings, observations, and results from Year 1 operation of the air sparging (AS) groundwater interim measure (IM) for High-Concentration Plumes (HCPs) and Low-Concentration Plumes (LCPs) within the perimeter fence line at Launch Complex 39A (LC39A) located at Kennedy Space Center (KSC), Florida. The objective of the LC39A groundwater IM is to actively decrease concentrations of trichloroethene (TCE), cis-1,2-dichloroethene (cDCE), and vinyl chloride (VC) in groundwater in the HCP and LCP within the pad perimeter fence line via AS to levels less than Florida Department of Environmental Protection (FDEP) Groundwater Cleanup Target Levels (GCTLs). The objective was developed because LC39A is currently being leased to Space Exploration Technologies (SpaceX), and the original IM for monitored natural attenuation (MNA) over an extended period of time was not suitable for future planned site use.

STS-52 Columbia, OV-102, soars into the sky after liftoff from KSC LC Pad 39B

NASA Image and Video Library

1992-10-22

STS052-S-053 (22 Oct. 1992) --- This low-angle 35mm image shows the space shuttle Columbia on its way toward a ten-day Earth-orbital mission with a crew of five NASA astronauts and a Canadian payload specialist. Liftoff occurred at 1:09:39 p.m. (EDT), Oct. 22, from Kennedy Space Center?s (KSC) Launch Pad 39B. Crew members onboard are astronauts James D. Wetherbee, Michael A. Baker, Tamara E. Jernigan, Charles L. (Lacy) Veach and William M. Shepherd, along with payload specialist Steven G. MacLean. Payloads onboard include the Laser Geodynamic Satellite II (LAGEOS II), which will be deployed early in the mission, a series of Canadian experiments, and the United States Microgravity Payload-1 (USMP-1). Photo credit: NASA

KSC-2014-2103

NASA Image and Video Library

2014-04-14

CAPE CANAVERAL, Fla. -- At Kennedy Space Center's Launch Pad 39A, Gwynne Shotwell, president and chief operating officer of Space Exploration Technologies SpaceX of Hawthorne, Calif., speaks to members of the news media announcing that NASA has just signed a lease agreement with SpaceX for use and operation of Launch Complex 39A. SpaceX will use Launch Complex 39A for rockets such as the Falcon Heavy, currently under development. Both launch pad 39A and 39B were originally built for the Apollo/Saturn V rockets that launched American astronauts on their historic journeys to the moon and later modified to support the 30-year shuttle program. Pad 39B is now being modified by NASA to support the Space Launch System SLS rocket boosting the Orion spacecraft part of the agency’s plan to explore beyond low-Earth orbit. To learn more about Launch Pad 39A visit: http://www.nasa.gov/mission_pages/shuttle/launch/launch-complex39-toc.html Photo credit: NASA/Dan Casper

KSC-2014-2098

NASA Image and Video Library

2014-04-14

CAPE CANAVERAL, Fla. -- At Kennedy Space Center's Launch Pad 39A, center director Bob Cabana announces that NASA has just signed a lease agreement with Space Exploration Technologies SpaceX of Hawthorne, Calif., for use and operation of Launch Complex 39A. NASA Administrator Charlie Bolden, left, and Gwynne Shotwell, president and chief operating officer of SpaceX, look on. SpaceX will use Launch Complex 39A for rockets such as the Falcon Heavy, currently under development. Both launch pad 39A and 39B were originally built for the Apollo/Saturn V rockets that launched American astronauts on their historic journeys to the moon and later modified to support the 30-year shuttle program. Pad 39B is now being modified by NASA to support the Space Launch System SLS rocket boosting the Orion spacecraft part of the agency’s plan to explore beyond low-Earth orbit. To learn more about Launch Pad 39A visit: http://www.nasa.gov/mission_pages/shuttle/launch/launch-complex39-toc.html Photo credit: NASA/Dan Casper

KSC-2014-2102

NASA Image and Video Library

2014-04-14

CAPE CANAVERAL, Fla. -- At Kennedy Space Center's Launch Pad 39A, Gwynne Shotwell, president and chief operating officer of Space Exploration Technologies SpaceX of Hawthorne, Calif., announces that NASA has just signed a lease agreement with SpaceX for use and operation of Launch Complex 39A. NASA Administrator Charlie Bolden, left, and Kennedy Space Center Director Bob Cabana listen. SpaceX will use Launch Complex 39A for rockets such as the Falcon Heavy, currently under development. Both launch pad 39A and 39B were originally built for the Apollo/Saturn V rockets that launched American astronauts on their historic journeys to the moon and later modified to support the 30-year shuttle program. Pad 39B is now being modified by NASA to support the Space Launch System SLS rocket boosting the Orion spacecraft part of the agency’s plan to explore beyond low-Earth orbit. To learn more about Launch Pad 39A visit: http://www.nasa.gov/mission_pages/shuttle/launch/launch-complex39-toc.html Photo credit: NASA/Dan Casper

KSC-2014-2104

NASA Image and Video Library

2014-04-14

CAPE CANAVERAL, Fla. -- At Kennedy Space Center's Launch Pad 39A, from the left, NASA Administrator Charlie Bolden, Gwynne Shotwell, president and chief operating officer of Space Exploration Technologies SpaceX and Kennedy Space Center Director Bob Cabana pose in from the of the historic launch complex after announcing that NASA has just signed a lease agreement with SpaceX for use and operation of Launch Complex 39A. SpaceX will use Launch Complex 39A for rockets such as the Falcon Heavy, currently under development. Both launch pad 39A and 39B were originally built for the Apollo/Saturn V rockets that launched American astronauts on their historic journeys to the moon and later modified to support the 30-year shuttle program. Pad 39B is now being modified by NASA to support the Space Launch System SLS rocket boosting the Orion spacecraft part of the agency’s plan to explore beyond low-Earth orbit. To learn more about Launch Pad 39A visit: http://www.nasa.gov/mission_pages/shuttle/launch/launch-complex39-toc.html Photo credit: NASA/Dan Casper

STS-112 Atlantis Launch from LC-39B

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. - Looking like a star balanced on a stem of smoke, Space Shuttle Atlantis shoots through the clear blue sky after launch on mission STS-112, the 15th assembly flight to the International Space Station. Liftoff from Launch Pad 39B occurred at 3:46 p.m. EDT. Atlantis carries the S1 Integrated Truss Structure and the Crew and Equipment Translation Aid (CETA) Cart A. The CETA is the first of two human-powered carts that will ride along the ISS railway, providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss.

STS-112 Atlantis Launch from LC-39B

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. - -- Space Shuttle Atlantis leaves a billowingclouds of smoke and steam behind just after liftoff from Launch Pad 39B on mission STS-112. Liftoff occurred on time at 3:46 p.m. EDT. Along with a crew of six, Atlantis carries the S1 Integrated Truss Structure and the Crew and Equipment Translation Aid (CETA) Cart A to the International Space Station (ISS). The CETA is the first of two human-powered carts that will ride along the ISS railway, providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss.

Prevalence, severity, and impact on quality of life of restless leg syndrome in patients with liver cirrhosis in India.

PubMed

Goel, Amit; Jat, Shankar Lal; Sasi, Avani; Paliwal, Vimal Kumar; Aggarwal, Rakesh

2016-05-01

Restless leg syndrome (RLS) has recently been shown to be increased in patients with liver cirrhosis (LC). We prospectively studied the prevalence and severity of RLS, and the effect of its presence on the quality of life (QoL) in Indian patients with LC. Adult patients with stable LC (n = 121; 98 male; median age 47 [range 18-68] years; Child-Pugh class A/B/C 59/39/23), were prospectively enrolled along with a group of healthy, adult controls (n = 121; 84 male; median age 42 [19-70] years). Patients with recent (<4 weeks) worsening were excluded. The subjects underwent an initial screening for RLS, followed by a re-evaluation to confirm the diagnosis, using the International RLS Diagnostic Criteria, and assessment of its severity. All participants underwent QoL assessment. RLS was commoner in LC patients (8/121; 6.6 %) than in controls (1/121; p < 0.05; odds ratio = 8.5 [1.1-69.0]). Presence of RLS showed no association with specific gender (male 7/98, female 1/23), Child-Pugh class (A 5/59, B 1/39 and C 2/23) or cause of liver disease (alcohol 3/32, hepatitis B 1/18, hepatitis C 3/28, and cryptogenic 1/25). RLS severity was moderate (5), severe (2), or very severe (1). Though QoL scores were lower in patients with LC than in controls, those in patients with and without RLS were similar. RLS was commoner in patients with LC than in controls, but did not correlate with liver disease severity and did not adversely influence QoL in LC.

Operational Lessons Learned from the Ares I-X Flight Test

NASA Technical Reports Server (NTRS)

Davis, Stephan R.

2010-01-01

The Ares I-X flight test, launched in 2009, is the first test of the Ares I crew launch vehicle. This development flight test evaluated the flight dynamics, roll control, and separation events, but also provided early insights into logistical, stacking, launch, and recovery operations for Ares I. Operational lessons will be especially important for NASA as the agency makes the transition from the Space Shuttle to the Constellation Program, which is designed to be less labor-intensive. The mission team itself comprised only 700 individuals over the life of the project compared to the thousands involved in Shuttle and Apollo missions; while missions to and beyond low-Earth orbit obviously will require additional personnel, this lean approach will serve as a model for future Constellation missions. To prepare for Ares I-X, vehicle stacking and launch infrastructure had to be modified at Kennedy Space Center's Vehicle Assembly Building (VAB) as well as Launch Complex (LC) 39B. In the VAB, several platforms and other structures designed for the Shuttle s configuration had to be removed to accommodate the in-line, much taller Ares I-X. Vehicle preparation activities resulted in delays, but also in lessons learned for ground operations personnel, including hardware deliveries, cable routing, transferred work and custodial paperwork. Ares I-X also proved to be a resource challenge, as individuals and ground service equipment (GSE) supporting the mission also were required for Shuttle or Atlas V operations at LC 40/41 at Cape Canaveral Air Force Station. At LC 39B, several Shuttle-specific access arms were removed and others were added to accommodate the in-line Ares vehicle. Ground command, control, and communication (GC3) hardware was incorporated into the Mobile Launcher Platform (MLP). The lightning protection system at LC 39B was replaced by a trio of 600-foot-tall towers connected by a catenary wire to account for the much greater height of the vehicle. Like Shuttle, Ares I-X will be stacked on a MLP and rolled out to the pad on a Saturn-era crawler-transporter. While Ares I-X was only held in place by the four hold-down posts on its aft skirt during rollout, a new vehicle stabilization system (VSS) attached to the vertical service structure kept the vehicle from undue swaying prior to launch at the pad, LC 39B. Following the launch, the flight test vehicle first stage was recovered with the aid of new parachutes resized to accommodate the five-segment-long first stage, which had a much greater length and mass than the Shuttle s reusable solid rocket boosters. After splashdown, recovery divers exercised extra care when handling the first stage to ensure that the flight data recorders in the fifth segment simulator were not damaged by exposure to sea water. The data recovered from the Ares I-X flight test will be very valuable in verifying the predicted environments and models used to design the vehicle. Lessons learned from Ares I-X will be shared with the Ares Projects through written and verbal reports and through integration of mission team members into the Project workforce.

Water Flow Test at Launch Complex 39B

NASA Image and Video Library

2017-12-20

Water flowed during a test at Launch Complex 39B at NASA’s Kennedy Space Center in Florida. About 450,000 gallons of water flowed at high speed from a holding tank through new and modified piping and valves, the flame trench, flame deflector nozzles and mobile launcher interface risers during a wet flow test at Launch Complex 39B. At peak flow, the water reached about 100 feet in the air above the pad surface. The test was a milestone to confirm and baseline the performance of the Ignition Overpressure/Sound Suppression system. During launch of NASA's Space Launch System rocket and Orion spacecraft, the high-speed water flow will help protect the vehicle from the extreme acoustic and temperature environment during ignition and liftoff.

CCP Astronauts at LC 39A and SpaceX Recovery Ship

NASA Image and Video Library

2018-03-28

Commercial Crew Astronauts Bob Behnken , Eric Boe, Doug Hurley, and Suni Williams survey SpaceX's progress at Launch Complex 39 A. The survey helped ensure the was familiar with the launch complex and recovery ship prior to missions to station.

Improved parameters of seven Kepler giant companions characterized with SOPHIE and HARPS-N

NASA Astrophysics Data System (ADS)

Bonomo, A. S.; Sozzetti, A.; Santerne, A.; Deleuil, M.; Almenara, J.-M.; Bruno, G.; Díaz, R. F.; Hébrard, G.; Moutou, C.

2015-03-01

Radial-velocity observations of Kepler candidates obtained with the SOPHIE and HARPS-N spectrographs have permitted unveiling the nature of the five giant planets Kepler-41b, Kepler-43b, Kepler-44b, Kepler-74b, and Kepler-75b, the massive companion Kepler-39b, and the brown dwarf KOI-205b. These companions were previously characterized with long-cadence (LC) Kepler data. Here we aim at refining the parameters of these transiting systems by i) modelling the published radial velocities and Kepler short-cadence (SC) data that provide a much better sampling of the transits; ii) performing new spectral analyses of the SOPHIE and ESPaDOnS spectra, after improving our procedure for selecting and co-adding the SOPHIE spectra of faint stars (Kp ≳ 14); and iii) improving stellar rotation periods hence stellar age estimates through gyrochronology, when possible, by using all the available LC data up to quarter Q17. Posterior distributions of the system parameters were derived with a differential evolution Markov chain Monte Carlo approach. Our main results are as follows: a) Kepler-41b is significantly larger and less dense than previously found because a lower orbital inclination is favoured by SC data. This also affects the determination of the geometric albedo that is lower than previously derived: Ag< 0.135; b) Kepler-44b is moderately smaller and denser than reported in the discovery paper, as a consequence of the slightly shorter transit duration found with SC data; c) good agreement was achieved with published Kepler-43, Kepler-75, and KOI-205 system parameters, although the host stars Kepler-75 and KOI-205 were found to be slightly richer in metals and hotter, respectively; d) the previously reported non-zero eccentricities of Kepler-39b and Kepler-74b might be spurious. If their orbits were circular, the two companions would be smaller and denser than in the eccentric case. The radius of Kepler-39b is still larger than predicted by theoretical isochrones. Its parent star is hotter and richer in metals than previously determined. Tables 2-8 are available in electronic form at http://www.aanda.org

STS-26 crew during emergency egress exercise at LC 39 launch pad B

NASA Image and Video Library

1988-05-04

S88-40898 (4 May 1988) --- Astronauts, members of the orbiter close-out crew and fire and rescue personnel participate in a simulated emergency egress exercise near the slide wire termination point bunker at Launch Pad 39B. The simulated exercise was performed to familiarize personnel with evacuation routes as well as emergency equipment and procedures. Reasons for conducting the emergency exercises include the need to validate recent post-Challenger upgrades to the launch pad's emergency escape system and the new procedures developed in preparation for STS-26. (NOTE: The astronaut pictured and many of the others who participated in the exercises are not members of STS-26 prime crew).

19. VIEW FROM WEST BELOW THE DAMLEVEL Copy photograph of ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

19. VIEW FROM WEST BELOW THE DAM--LEVEL Copy photograph of photogrammetric plate LC-HAER-GS05-B-1971-1101L. - Mountain Dell Dam, Parley's Canyon, Northwest side of I-80, West of State Route 39, Salt Lake City, Salt Lake County, UT

STS-27 Atlantis, OV-104, terminal countdown demonstration test (TCDT) at KSC

NASA Technical Reports Server (NTRS)

1988-01-01

STS-27 Atlantis, Orbiter Vehicle (OV) 104, crewmembers participate in the terminal countdown demonstration test (TCDT) at the Kennedy Space Center (KSC). Commander Robert L. Gibson, waving to spectators and followed by Pilot Guy S. Gardner, Mission Specialist (MS) William M. Shepherd, MS Richard M. Mullane, and MS Jerry L. Ross, leads crew from the Operations and Checkout (O and C) Building to launch complex (LC) pad 39B. In the very back of the group and just exiting through doorway are Donald R. Puddy (left) and astronaut Daniel C. Brandenstein. Crewmembers are wearing launch and entry suits (LESs).

STS-87 Commander Kregel holds the crew patch in front of Columbia's entry hatch at LC 39B during TCD

NASA Technical Reports Server (NTRS)

1997-01-01

STS-87 Commander Kevin Kregel holds the crew patch in front of Columbia's entry hatch at Launch Pad 39B during Terminal Countdown Demonstration Test (TCDT) activities. The crew of the STS-87 mission is scheduled for launch Nov. 19 aboard the Space Shuttle Columbia. The TCDT is held at KSC prior to each Space Shuttle flight providing the crew of each mission opportunities to participate in simulated countdown activities. The TCDT ends with a mock launch countdown culminating in a simulated main engine cut-off. The crew also spends time undergoing emergency egress training exercises at the pad and has an opportunity to view and inspect the payloads in the orbiter's payload bay.

Preoperative intravenous parecoxib reduces length of stay on ambulatory laparoscopic cholecystectomy.

PubMed

Shuying, Li; Xiao, Wang; Peng, Liang; Tao, Zhu; Ziying, Lu; Liang, Zhao

2014-01-01

The complexity of pain after laparoscopic cholecystectomy (LC) needs multi-module analgesia. Opioids are widely used for perioperative pain but associated with numerous adverse effects. We investigated the effect of parecoxib administrated preoperatively and postoperatively for analgesia after ambulatory laparoscopic cholecystectomy. 120 patients scheduled for ambulatory LC with general anesthesia were randomly assigned to three groups: group A received 40 mg parecoxib injection 30-45 min before anesthesia induction and 4 ml saline injection when gallbladder was removed; group B received 4 ml saline injection 30-45 min before anesthesia induction and 40 mg parecoxib injection when gallbladder was removed; group C received 4 ml saline injection 30-45 min before anesthesia induction and the time when gallbladder was removed. We recorded the time achieve to modified Aldrete's score > 9 in the post-anesthesia care unit (PACU) and modified Post-Anesthetic Discharge Scoring System (PADSS) > 9 in ambulatory unit. The visual analog scale (VAS) was used to assess the degree of the postoperative pain in the first 24 h, and the numbers of patients who need additional analgesic and postoperative adverse effects were also recorded. Patients of group A had a shorter length of stay (LOS) in PACU compared to these of group B and group C (32.4 ± 7.2 min vs. 39.1 ± 10.4 min and 42.2 ± 7.6 min, P < 0.05). Patients of group A also had a shorter discharge time compared to these of group B and group C (148.4 ± 39.3 min vs. 187.9 ± 47.7 min and 223.4 ± 52.5 min, P < 0.05). Moreover, patients of group A experienced reduced pain intensity, less postoperative side effect, and less additional analgesic requirement. Preoperative administration of parecoxib for postoperative analgesia provided significant effect on reducing PACU length of stay (LOS) and discharge time, and improving patient outcome after ambulatory LC. Copyright © 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

View of the Apollo 10 space vehicle at Pad B, ready for launch

NASA Technical Reports Server (NTRS)

1969-01-01

Ground-level view at sunset of the Apollo 10 (Spacecraft 106/Lunar Module 4/Saturn 505) space vehicle at Pad B, Launch Complex 39, Kennedy Space Center. The Apollo 10 stack had just been positioned after being rolled out from the Vehicle Assemble Building (VAB) (34318); View of the Apollo 10 space vehicle (through palm trees and across water) on the way from the VAB to Pad B, Launch Complex 39. The Saturn V and its mobile launch tower are atop a crawler-transporter (34319).

Kennedy Space Center (KSC) Launch Complex 39 (LC-39) Gaseous Hydrogen (GH2) Vent Arm Behavior Prediction Model Review Technical Assessment Report

NASA Technical Reports Server (NTRS)

Wilson, Timmy R.; Beech, Geoffrey; Johnston, Ian

2009-01-01

The NESC Assessment Team reviewed a computer simulation of the LC-39 External Tank (ET) GH2 Vent Umbilical system developed by United Space Alliance (USA) for the Space Shuttle Program (SSP) and designated KSC Analytical Tool ID 451 (KSC AT-451). The team verified that the vent arm kinematics were correctly modeled, but noted that there were relevant system sensitivities. Also, the structural stiffness used in the math model varied somewhat from the analytic calculations. Results of the NESC assessment were communicated to the model developers.

Suppression of Akt-mediated HDAC3 expression and CDK2 T39 phosphorylation by a bichalcone analog contributes to S phase retardation of cancer cells.

PubMed

Hung, Kuang-Chen; Lin, Meng-Liang; Hsu, Shih-Wei; Lee, Chuan-Chun; Huang, Ren-Yu; Wu, Tian-Shung; Chen, Shih-Shun

2018-06-15

Targeting cell cycle regulators has been a suggested mechanism for therapeutic cancer strategies. We report here that the bichalcone analog TSWU-CD4 induces S phase arrest of human cancer cells by inhibiting the formation of cyclin A-phospho (p)-cyclin-dependent kinase 2 (CDK2, threonine [Thr] 39) complexes, independent of mutant p53 expression. Ectopic expression of CDK2 (T39E), which mimics phosphorylation of the Thr 39 residue of CDK2, partially rescues the cells from TSWU-CD4-induced S phase arrest, whereas phosphorylation-deficient CDK2 (T39A) expression regulates cell growth with significant S phase arrest and enhances TSWU-CD4-triggered S phase arrest. Decreased histone deacetylase 3 (HDAC3) expression after TSWU-CD4 treatment was demonstrated, and TSWU-CD4 induced S phase arrest and inhibitory effects on cyclin A expression and CDK2 Thr 39 phosphorylation, while cyclin A-p-CDK2 (Thr 39) complex formation was suppressed by ectopic wild-type HDAC3 expression. The co-transfection of CDK2 (T39E) along with HDAC3 completely restored cyclin A expression, Thr 39-phosphorylated CDK2, cyclin A-p-CDK2 (Thr 39) complex formation, and the S phase population to normal levels. Protein kinase B (Akt) inactivation was required for TSWU-CD4-induced S phase cell cycle arrest, because constitutively active Akt1 blocks the induction of S phase arrest and the suppression of cyclin A and HDAC3 expression, CDK2 Thr 39 phosphorylation, and cyclin A-p-CDK2 (Thr 39) complex formation by TSWU-CD4. Taken together, our results indicate that TSWU-CD4 induces S phase arrest by inhibiting Akt-mediated HDAC3 expression and CDK2 Thr 39 phosphorylation to suppress the formation of cyclin A-p-CDK2 (Thr 39) complexes. Copyright © 2018 Elsevier B.V. All rights reserved.

Floodlights illuminate view of Skylab 3 vehicle at Pad B, Launch Complex 39

NASA Image and Video Library

1973-07-20

S73-32568 (20 July 1973) --- Floodlights illuminate this nighttime view of the Skylab 3/Saturn 1B space vehicle at Pad B, Launch Complex 39, Kennedy Space Center, Florida, during prelaunch preparations. The reflection is the water adds to the scene. In addition to the Command/Service Module and its launch escapte system, the Skylab 3 space vehicle consists of the Saturn 1B first (S-1B) stage and the Saturn 1B second (S-IVB) stage. The crew for the scheduled 59-day Skylab 3 mission in Earth orbit will be astronauts Alan L. Bean, Owen K. Garriott and Jack R. Lousma. Skylab 3 was launched on July 28, 1973. Photo credit: NASA

STS-112 Atlantis Launch from LC-39B

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- Space Shuttle Atlantis roars into the clear blue sky from the billows of smoke below after launch on mission STS-112, the 15th assembly flight to the International Space Station. Liftoff from Launch Pad 39B occurred at 3:46 p.m. EDT. Atlantis carries the S1 Integrated Truss Structure and the Crew and Equipment Translation Aid (CETA) Cart A. The CETA is the first of two human-powered carts that will ride along the ISS railway, providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss. providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss to the Station.

STS-87 Mission Specialist Chawla is assisted with her launch and entry spacesuit at LC 39B during TC

NASA Technical Reports Server (NTRS)

1997-01-01

STS-87 Mission Specialist Kalpana Chawla, Ph.D., is assisted with her orange launch and entry spacesuit by NASA suit technicians at Launch Pad 39B during Terminal Countdown Demonstration Test (TCDT) activities. The crew of the STS-87 mission is scheduled for launch Nov. 19 aboard the Space Shuttle Columbia. The TCDT is held at KSC prior to each Space Shuttle flight providing the crew of each mission opportunities to participate in simulated countdown activities. The TCDT ends with a mock launch countdown culminating in a simulated main engine cut-off. The crew also spends time undergoing emergency egress training exercises at the pad and has an opportunity to view and inspect the payloads in the orbiter's payload bay.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stepanyuk, Galina A.; Serrano, Pedro; Peralta, Eigen

RNA-binding protein 39 (RBM39) is a splicing factor and a transcriptional co-activator of estrogen receptors and Jun/AP-1, and its function has been associated with malignant progression in a number of cancers. The C-terminal RRM domain of RBM39 belongs to the U2AF homology motif family (UHM), which mediate protein–protein interactions through a short tryptophan-containing peptide known as the UHM-ligand motif (ULM). Here, crystal and solution NMR structures of the RBM39-UHM domain, and the crystal structure of its complex with U2AF65-ULM, are reported. The RBM39–U2AF65 interaction was confirmed by co-immunoprecipitation from human cell extracts, by isothermal titration calorimetry and by NMR chemicalmore » shift perturbation experiments with the purified proteins. When compared with related complexes, such as U2AF35–U2AF65 and RBM39–SF3b155, the RBM39-UHM–U2AF65-ULM complex reveals both common and discriminating recognition elements in the UHM–ULM binding interface, providing a rationale for the known specificity of UHM–ULM interactions. This study therefore establishes a structural basis for specific UHM–ULM interactions by splicing factors such as U2AF35, U2AF65, RBM39 and SF3b155, and a platform for continued studies of intermolecular interactions governing disease-related alternative splicing in eukaryotic cells.« less

Rare view of two space shuttles on adjacent KSC Launch Complex (LC) 39 pads

NASA Technical Reports Server (NTRS)

1990-01-01

Rare view shows two space shuttles on adjacent Kennedy Space Center (KSC) Launch Complex (LC) 39 pads with the Rotating Service Structures (RSS) retracted. STS-35 Columbia, Orbiter Vehicle (OV) 102, is on Pad A (foreground) is being readied for a September 6 early morning launch, while its sister spaceship, Discovery, OV-103, is set to begin preparations for an October liftoff on Mission STS-41. View provided by KSC with alternate number KSC-90PC-1269. Also see S90-48650 for similar view with alternate KSC number KSC-90PC-1268.

Rare view of two space shuttles on adjacent KSC Launch Complex (LC) 39 pads

NASA Technical Reports Server (NTRS)

1990-01-01

Rare view shows two space shuttles on adjacent Kennedy Space Center (KSC) Launch Complex (LC) 39 pads with the Rotating Service Structures (RSS) retracted. STS-35 Columbia, Orbiter Vehicle (OV) 102, is on Pad A (foreground) and being readied for a September 6 early morning launch, while its sister spaceship, Discovery, OV-103, is prepared for an October liftoff on Mission STS-41. View provided by KSC with alternate number KSC-90PC-1268. Also see S90-48904 for a similar view with alternate KSC number KSC-90PC-1269.

STS-26 crewmembers leave KSC O&C Bldg on their way to the launch pad

NASA Image and Video Library

1988-09-29

STS-26 crewmembers, suited in launch and entry suits (LESs), leave the Kennedy Space Center (KSC) Operations and Checkout (O&C) Building on their way to the launch complex (LC) pad 39B where they will board Discovery, Orbiter Vehicle (OV) 103. Commander Frederick H. Hauck, waving to spectators, is followed by Pilot Richard O. Covey, Mission Specialist (MS) John M. Lounge, MS David C. Hilmers, and MS George D. Nelson. Others accompanying the crew are JSC Flight Crew Operations Directorate (FCOD) Director Donald R. Puddy, Astronaut Office Chief Daniel C. Brandenstein, and a Crew Training Officer Richard W. Nygren.

Final Flame Trench Brick Installation at Launch Pad 39B

NASA Image and Video Library

2017-05-09

The final brick was installed on the north side of the flame trench at Launch Complex 39B at NASA’s Kennedy Space Center in Florida. The walls of the flame trench are being upgraded to withstand the intense heat and fire at launch of NASA's Space Launch System rocket with Orion atop. About 96,000 heat-resistant bricks, in three different sizes, were secured to the walls using bonding mortar in combination with adhesive anchors. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to Pad 39B to support the launch of the SLS and Orion spacecraft for Exploration Mission-1 and NASA’s journey to Mars.

Final Flame Trench Brick Installation at Launch Pad 39B

NASA Image and Video Library

2017-05-09

Construction workers sign the final bricks after they were installed on the north side of the flame trench at Launch Complex 39B at NASA’s Kennedy Space Center in Florida. The walls of the flame trench are being upgraded to withstand the intense heat and fire at launch of NASA's Space Launch System rocket with Orion atop. About 96,000 heat-resistant bricks, in three different sizes, were secured to the walls using bonding mortar in combination with adhesive anchors. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to Pad 39B to support the launch of the SLS and Orion spacecraft for Exploration Mission-1 and NASA’s journey to Mars.

Final Flame Trench Brick Installation at Launch Pad 39B

NASA Image and Video Library

2017-05-09

A construction worker installs one of the final bricks on the north side of the flame trench at Launch Complex 39B at NASA's Kennedy Space Center in Florida. The walls of the flame trench are being upgraded to withstand the intense heat and fire at launch of NASA's Space Launch System rocket with Orion atop. About 96,000 heat-resistant bricks, in three different sizes, were secured to the walls using bonding mortar in combination with adhesive anchors. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to Pad 39B to support the launch of the SLS and Orion spacecraft for Exploration Mission-1 and NASA’s journey to Mars.

Final Flame Trench Brick Installation at Launch Pad 39B

NASA Image and Video Library

2017-05-09

A view looking up from the north side of the flame trench beneath the pad at Launch Complex 39B at NASA's Kennedy Space Center in Florida. The walls of the flame trench are being upgraded to withstand the intense heat and fire at launch of NASA's Space Launch System rocket with Orion atop. About 96,000 heat-resistant bricks, in three different sizes, were secured to the walls using bonding mortar in combination with adhesive anchors. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to Pad 39B to support the launch of the SLS and Orion spacecraft for Exploration Mission-1 and NASA’s journey to Mars.

Final Flame Trench Brick Installation at Launch Pad 39B

NASA Image and Video Library

2017-05-09

Preparations are underway to install the final brick on the north side of the flame trench at Launch Complex 39B at NASA's Kennedy Space Center in Florida. The walls of the flame trench are being upgraded to withstand the intense heat and fire at launch of NASA's Space Launch System rocket with Orion atop. About 96,000 heat-resistant bricks, in three different sizes, were secured to the walls using bonding mortar in combination with adhesive anchors. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to Pad 39B to support the launch of the SLS and Orion spacecraft for Exploration Mission-1 and NASA’s journey to Mars.

Final Flame Trench Brick Installation at Launch Pad 39B

NASA Image and Video Library

2017-05-09

A construction worker installs the final brick on the north side of the flame trench at Launch Complex 39B at NASA's Kennedy Space Center in Florida. The walls of the flame trench are being upgraded to withstand the intense heat and fire at launch of NASA's Space Launch System rocket with Orion atop. About 96,000 heat-resistant bricks, in three different sizes, were secured to the walls using bonding mortar in combination with adhesive anchors. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to Pad 39B to support the launch of the SLS and Orion spacecraft for Exploration Mission-1 and NASA’s journey to Mars.

Final Flame Trench Brick Installation at Launch Pad 39B

NASA Image and Video Library

2017-05-09

Construction workers install the final bricks on the north side of the flame trench at Launch Complex 39B at NASA's Kennedy Space Center in Florida. The walls of the flame trench are being upgraded to withstand the intense heat and fire at launch of NASA's Space Launch System rocket with Orion atop. About 96,000 heat-resistant bricks, in three different sizes, were secured to the walls using bonding mortar in combination with adhesive anchors. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to Pad 39B to support the launch of the SLS and Orion spacecraft for Exploration Mission-1 and NASA’s journey to Mars.

Epstein-Barr Virus (EBV) Latent Protein EBNA3A Directly Targets and Silences the STK39 Gene in B Cells Infected by EBV.

PubMed

Bazot, Quentin; Paschos, Kostas; Allday, Martin J

2018-04-01

Epstein-Barr virus (EBV) establishes latent infection in human B cells and is associated with a wide range of cancers. The EBV nuclear antigen 3 (EBNA3) family proteins are critical for B cell transformation and function as transcriptional regulators. It is well established that EBNA3A and EBNA3C cooperate in the regulation of cellular genes. Here, we demonstrate that the gene STK39 is repressed only by EBNA3A. This is the first example of a gene regulated only by EBNA3A in EBV-transformed lymphoblastoid cell lines (LCLs) without the help of EBNA3C. This was demonstrated using a variety of LCLs carrying either knockout, revertant, or conditional EBNA3 recombinants. Investigating the kinetics of EBNA3A-mediated changes in STK39 expression showed that STK39 becomes derepressed quickly after EBNA3A inactivation. This derepression is reversible as EBNA3A reactivation represses STK39 in the same cells expressing a conditional EBNA3A. STK39 is silenced shortly after primary B cell infection by EBV, and no STK39 -encoded protein (SPAK) is detected 3 weeks postinfection. Chromatin immunoprecipitation (ChIP) analysis indicates that EBNA3A directly binds to a regulatory region downstream of the STK39 transcription start site. For the first time, we demonstrated that the polycomb repressive complex 2 with the deposition of the repressive mark H3K27me3 is not only important for the maintenance of an EBNA3A target gene ( STK39 ) but is also essential for the initial establishment of its silencing. Finally, we showed that DNA methyltransferases are involved in the EBNA3A-mediated repression of STK39 IMPORTANCE EBV is well known for its ability to transform B lymphocytes to continuously proliferating lymphoblastoid cell lines. This is achieved in part by the reprogramming of cellular gene transcription by EBV transcription factors, including the EBNA3 proteins that play a crucial role in this process. In the present study, we found that EBNA3A epigenetically silences STK39 This is the first gene where EBNA3A has been found to exert its repressive role by itself, without needing its coregulators EBNA3B and EBNA3C. Furthermore, we demonstrated that the polycomb repressor complex is essential for EBNA3A-mediated repression of STK39 Findings in this study provide new insights into the regulation of cellular genes by the transcription factor EBNA3A. Copyright © 2018 Bazot et al.

Flame Deflector Complete at Launch Complex 39B

NASA Image and Video Library

2018-05-16

Construction is complete on the main flame deflector in the flame trench at Launch Complex 39B at NASA's Kennedy Space Center in Florida. The flame deflector will safely deflect the plume exhaust from NASA's Space Launch System rocket during launch. It will divert the rocket's exhaust, pressure and intense heat to the north at liftoff. The Exploration Ground Systems Program at Kennedy is refurbishing the pad to support the launch of the SLS rocket and Orion on Exploration Mission-1, and helping to transform the space center into a multi-user spaceport.

Final Flame Trench Brick Installation at Launch Pad 39B

NASA Image and Video Library

2017-05-09

A view of the north side of the flame trench at Launch Complex 39B at NASA's Kennedy Space Center in Florida. The final brick was installed in the flame trench, completing about a year's worth of work to upgrade the walls to withstand the intense heat and fire at launch of NASA's Space Launch System rocket with Orion atop. About 96,000 heat-resistant bricks, in three different sizes, were secured to the walls using bonding mortar in combination with adhesive anchors. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to Pad 39B to support the launch of the SLS and Orion spacecraft for Exploration Mission-1 and NASA’s journey to Mars.

Large Crawler Crane for new lightning protection system

NASA Image and Video Library

2007-10-25

A large crawler crane arrives at the turn basin at the Launch Complex 39 Area on NASA's Kennedy Space Center. The crane with its 70-foot boom will be moved to Launch Pad 39B and used to construct a new lightning protection system for the Constellation Program and Ares/Orion launches. Pad B will be the site of the first Ares vehicle launch, including Ares I-X which is scheduled for April 2009.

SPACEHAB module at LC-39B for STS-76

NASA Technical Reports Server (NTRS)

1996-01-01

At Launch Pad 39B, the SPACEHAB module has been installed in the payload bay of the Space Shuttle Atlantis, which was rolled out to the pad a day previously. Already located in the payload bay was the Orbiter Docking System (ODS), to which the SPACEHAB was connected via a tunnel. During the upcoming flight of Atlantis on Mission STS-76, the ODS will be docked to the Docking Module located on the Kristall module docking port on the Russian Space Station Mir. The SPACEHAB will be filled with Russian and U.S. logistics equipment for transfer to Mir. Also located in the mini-research laboratory is the European Space Agency's Biorack, which houses experiments to be conducted by the U.S. astronauts during the nine-day flight. Atlantis is scheduled to lift off on the third Shuttle-Mir docking mission on March 21.

STS-30 Atlantis, OV-104, lifts off from KSC LC Pad 39B

NASA Image and Video Library

1989-05-04

STS030-S-109 (4 May 1989) --- Moments after ignition, Space Shuttle Atlantis heads for a four-day mission in Earth-orbit with five astronaut crew members aboard. Onboard were astronauts David M. Walker, Ronald. J. Grabe, Norman E. Thagard, Mary L. Cleave and Mark C. Lee. Launch occurred at 2:46:58 p.m. (EDT), May 4, 1989.

STS-30 Atlantis, OV-104, lifts off from KSC LC Pad 39B

NASA Image and Video Library

1989-05-04

STS030-S-108 (4 May 1989) --- Backdropped against slight gray Florida skies, Space Shuttle Atlantis heads for a four-day mission in earth orbit with five astronaut crewmembers aboard. Onboard were astronauts David. M. Walker, Ronald J. Grabe, Norman E. Thagard, Mary L. Cleave and Mark C. Lee. Launch occurred at 2:46:58 P.M. (EDT), May 4, 1989.

Large Crawler Crane for new lightning protection system

NASA Image and Video Library

2007-10-25

A large crawler crane begins moving away from the turn basin at the Launch Complex 39 Area on NASA's Kennedy Space Center. The crane with its 70-foot boom will be moved to Launch Pad 39B and used to construct a new lightning protection system for the Constellation Program and Ares/Orion launches. Pad B will be the site of the first Ares vehicle launch, including Ares I-X which is scheduled for April 2009.

03pd2202

NASA Image and Video Library

2003-07-23

KENNEDY SPACE CENTER, FLA. – This aerial view shows Launch Complex 39 Area. At center is the 525-foot-tall Vehicle Assembly Building. On the horizon at the far left is Launch Pad 39B; to the right is Launch Pad 39A. The crawlerway can be seen stretching from the VAB toward Pad A. Waters of the Banana Creek and Banana River surround the pads. At center right is the Turn Basin.

KSC-03pd2202

NASA Image and Video Library

2003-07-23

CAPE CANAVERAL, Fla. -- This aerial view shows the Launch Complex 39 Area. At center is the 525-foot-tall Vehicle Assembly Building. On the horizon at the far left is Launch Pad 39B to the right is Launch Pad 39A. The crawlerway can be seen stretching from the VAB toward Pad A. Waters of the Banana Creek and Banana River surround the pads. At center right is the Turn Basin. Photo credit: NASA

STS-65 Columbia, OV-102, lifts off from KSC Launch Complex (LC) Pad 39A

NASA Technical Reports Server (NTRS)

1994-01-01

Columbia, Orbiter Vehicle (OV) 102, atop its external tank (ET) rises above the Kennedy Space Center (KSC) Launch Complex (LC) Pad 39A after liftoff at 12:43 pm Eastern Daylight Time (EDT). OV-102 starboard side and one of the two solid rocket boosters (SRBs) are visible in this launch view. The retracted rotating service structure (RSS) is nearly covered in the shuttle's exhaust at the left as OV-102 clears the fixed service structure (FSS) tower. The space shuttle main engines produce a diamond shock effect. Once in orbit, STS-65's six NASA astronauts and a Japanese Payload Specialist will begin two weeks of experimentation in support of the second International Microgravity Laboratory (IML-2) mission.

Endeavour, Orbiter Vehicle (OV) 105, roll out to KSC Launch Complex Pad 39B

NASA Image and Video Library

1992-03-13

S92-34862 (13 March 1992) --- An otter, surprised by the unexpected presence of the photographer, seems unaware of the Space Shuttle Endeavour rolling behind it to Launch Pad 39B. Endeavour is the newest orbiter in the Shuttle fleet. Still ahead for Endeavour (OV-105) is a Flight Readiness Firing of its three main engines, and the Terminal Countdown Demonstration Test with the flight crew. Endeavour's maiden voyage on NASA's mission STS-49 will occur in late spring.

STS-28 Columbia, OV-102, lifts off from KSC Launch Complex Pad 39B

NASA Image and Video Library

1989-08-08

STS028-S-004 (8 Aug. 1989) --- Framed by Florida vegetation, Space Shuttle Columbia soars toward space for the STS-28 mission from Launch Pad 39-B. The spacecraft renews flight after a period of three and a half years, this time with five crewmembers aboard. Onboard the spacecraft are astronauts Brewster H. Shaw Jr., Richard N. Richards, David C. Leestma, James C. Adamson and Mark N. Brown. The last time Columbia was in space was in January of 1986.

7 CFR 15b.39 - Education of institutionalized persons.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 1 2011-01-01 2011-01-01 false Education of institutionalized persons. 15b.39 Section... § 15b.39 Education of institutionalized persons. A recipient to which this subpart applies that operates...)(2), in its program or activity is provided an appropriate education, as defined in § 15b.22(b...

7 CFR 15b.39 - Education of institutionalized persons.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 1 2012-01-01 2012-01-01 false Education of institutionalized persons. 15b.39 Section... § 15b.39 Education of institutionalized persons. A recipient to which this subpart applies that operates...)(2), in its program or activity is provided an appropriate education, as defined in § 15b.22(b...

7 CFR 15b.39 - Education of institutionalized persons.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 1 2014-01-01 2014-01-01 false Education of institutionalized persons. 15b.39 Section... § 15b.39 Education of institutionalized persons. A recipient to which this subpart applies that operates...)(2), in its program or activity is provided an appropriate education, as defined in § 15b.22(b...

7 CFR 15b.39 - Education of institutionalized persons.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 1 2013-01-01 2013-01-01 false Education of institutionalized persons. 15b.39 Section... § 15b.39 Education of institutionalized persons. A recipient to which this subpart applies that operates...)(2), in its program or activity is provided an appropriate education, as defined in § 15b.22(b...

7 CFR 15b.39 - Education of institutionalized persons.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Education of institutionalized persons. 15b.39 Section... § 15b.39 Education of institutionalized persons. A recipient to which this subpart applies that operates...)(2), in its program or activity is provided an appropriate education, as defined in § 15b.22(b...

Membrane fractions active in poliovirus RNA replication contain VPg precursor polypeptides

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takegami, T.; Semler, B.L.; Anderson, C.W.

1983-01-01

The poliovirus specific polypeptide P3-9 is of special interest for studies of viral RNA replication because it contains a hydrophobic region and, separated by only seven amino acids from that region, the amino acid sequence of the genome-linked protein VPg. Membraneous complexes of poliovirus-infected HeLa cells that contain poliovirus RNA replicating proteins have been analyzed for the presence of P3-9 by immunoprecipitation. Incubation of a membrane fraction rich in P3-9 with proteinase leaves the C-terminal 69 amino acids of P3-9 intact, an observation suggesting that this portion is protected by its association with the cellular membrane. These studies have alsomore » revealed two hitherto undescribed viral polypeptides consisting of amino acid sequences of the P2 andf P3 regions of the polyprotein. Sequence analysis by stepwise Edman degradation show that these proteins are 3b/9 (M/sub r/77,000) and X/9 (M/sub r/50,000). 3b/9 and X/9 are membrane bound and are turned over rapidly and may be direct precursors to proteins P2-X and P3-9 of the RNA replication complex. P2-X, a polypeptide void of hydrophobic amino acid sequences but also found associated with membranes, is rapidly degraded when the membraneous complex is treated with trypsin. It is speculated that P2-X is associated with membranes by its affinity to the N-terminus of P3-9.« less

Crystallization of the rice immune receptor RGA5A_S with the rice blast fungus effector AVR1-CO39 prepared via mixture and tandem strategies.

PubMed

Guo, Liwei; Zhang, Yikun; Ma, Mengqi; Liu, Qiang; Zhang, Yanan; Peng, Youliang; Liu, Junfeng

2018-04-01

RGA5 is a component of the Pia resistance-protein pair (RGA4/RGA5) from Oryza sativa L. japonica. It acts as an immune receptor that directly recognizes the effector AVR1-CO39 from Magnaporthe oryzae via a C-terminal non-LRR domain (RGA5A_S). The interaction between RGA5A_S and AVR1-CO39 relieves the repression of RGA4, leading to effector-independent cell death. To determine the structure of the complex of RGA5A_S and AVR1-CO39 and to understand the details of this interaction, the complex was prepared by fusing the proteins together, by mixing them in vitro or by co-expressing them in one host cell. Samples purified via the first two strategies were crystallized under two different conditions. A mixture of AVR1-CO39 and RGA5A_S (complex I) crystallized in 1.1 M ammonium tartrate dibasic, 0.1 M sodium acetate-HCl pH 4.6, while crystals of the fusion complex RGA5A_S-TEV-AVR1-CO39 (complex II) were grown in 2 M NaCl. The crystal of complex I belonged to space group P3 1 21, with unit-cell parameters a = b = 66.2, c = 108.8 Å, α = β = 90, γ = 120°. The crystals diffracted to a Bragg spacing of 2.4 Å, and one molecule each of RGA5A_S and AVR1-CO39 were present in the asymmetric unit of the initial model. The crystal of complex II belonged to space group I4, with unit-cell parameters a = b = 137.4, c = 66.2 Å, α = β = γ = 90°. The crystals diffracted to a Bragg spacing of 2.72 Å, and there were two molecules of RGA5A_S and two molecules of AVR1-CO39 in the asymmetric unit of the initial model. Further structural characterization of the interaction between RGA5A_S and AVR1-CO39 will lead to a better understanding of the mechanism underlying effector recognition by R proteins.

Effect of High Protein Diet and Probiotic Lactobacillus casei Shirota Supplementation in Aflatoxin B1-Induced Rats

PubMed Central

Nurul Adilah, Z.; Liew, Winnie-Pui-Pui; Amin, I.

2018-01-01

Probiotic Lactobacillus casei Shirota (LcS) is a potential decontaminating agent of aflatoxin B1 (AFB1). However, few studies have investigated the influence of diet, especially a high protein (HP) diet, on the binding of AFB1 by probiotics. This research was conducted to determine the effect of HP diet on the ability of LcS to bind AFB1 and reduce aflatoxin M1 (AFM1) in AFB1-induced rats. Sprague Dawley rats were randomly divided into three groups: A (HP only), B (HP + 108 CFU LcS + 25 μg AFB1/kg BW), and C (HP + 25 μg AFB1/kg BW). Levels of AST and ALP were higher in all groups but other liver function's biomarkers were in the normal range, and the liver's histology showed no structural changes. The urea level of rats in group B (10.02 ± 0.73 mmol/l) was significantly lower (p < 0.05) than that of rats in group A (10.82 ± 0.26 mmol/l). The presence of carcinoma in the small intestine and colon was more obvious in group C than in group B. Moreover, rats in group B had significantly (p < 0.05) lower AFM1 concentration (0.39 ± 0.01 ng/ml) than rats in group C (5.22 ± 0.28 ng/ml). Through these findings, LcS supplementation with HP diet alleviated the adverse effects of AFB1 by preventing AFB1 absorption in the small intestine and reducing urinary AFM1.

Two alternatively spliced GPR39 transcripts in seabream: molecular cloning, genomic organization, and regulation of gene expression by metabolic signals.

PubMed

Zhang, Yong; Liu, Yun; Huang, Xigui; Liu, Xiaochun; Jiao, Baowei; Meng, Zining; Zhu, Pei; Li, Shuisheng; Lin, Haoran; Cheng, Christopher H K

2008-12-01

Two GPR39 transcripts, designated as sbGPR39-1a and sbGPR39-1b, were identified in black seabream (Acanthopagrus schlegeli). The deduced amino acid (aa) sequence of sbGPR39-1a contains 423 residues with seven putative transmembrane (TM) domains. On the other hand, sbGPR39-1b contains 284 aa residues with only five putative TM domains. Northern blot analysis confirmed the presence of two GPR39 transcripts in the seabream intestine, stomach, and liver. Apart from seabream, the presence of two GPR39 transcripts was also found to exist in a number of teleosts (zebrafish and pufferfish) and mammals (human and mouse). Analysis of the GPR39 gene structure in different species suggests that the two GPR39 transcripts are generated by alternative splicing. When the seabream receptors were expressed in cultured HEK293 cells, Zn(2)(+) could trigger sbGPR39-1a signaling through the serum response element pathway, but no such functionality could be detected for the sbGPR39-1b receptor. The two receptors were found to be differentially expressed in seabream tissues. sbGPR39-1a is predominantly expressed in the gastrointestinal tract. On the other hand, sbGPR39-1b is widely expressed in most central and peripheral tissues except muscle and ovary. The expression of sbGPR39-1a in the intestine and the expression of sbGPR39-1b in the hypothalamus were decreased significantly during food deprivation in seabream. On the contrary, the expression of the GH secretagogue receptors (sbGHSR-1a and sbGHSR-1b) was significantly increased in the hypothalamus of the food-deprived seabream. The reciprocal regulatory patterns of expression of these two genes suggest that both of them are involved in controlling the physiological response of the organism during starvation.

STK39, But Not BST1, HLA-DQB1, and SPPL2B Polymorphism, Is Associated With Han-Chinese Parkinson's Disease in Taiwan

PubMed Central

Chang, Kuo-Hsuan; Wu, Yih-Ru; Chen, Yi-Chun; Fung, Hon-Chung; Lee-Chen, Guey-Jen; Chen, Chiung-Mei

2015-01-01

Abstract Neuroinflammation is emerging as an important pathway involved in Parkinson's disease (PD) pathogenesis. Herein, we investigated the effect of 4 top PD-associated genetic variants in Caucasians listed on the top risk loci identified by meta-analysis of genome wide-association studies in PDGene database (http://www.pdgene.org/top_results), including serine threonine kinase 39 (STK39) rs1955337, bone marrow stromal cell antigen 1 (BST1) rs11724635, major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1) rs9275326, and signal peptide peptidase-like 2B (SPPL2B) rs62120679, by genotyping 596 Han-Chinese patients with PD and 597 age-matched control subjects. Compared with subjects with STK39 rs1955337 GG genotype, those with TT genotype had a 1.64-fold increased risk of PD (95% confidence interval: 1.13–2.39, P = 0.010). The recessive model also demonstrated an increased PD risk in TT genotype (odds ratio: 1.59, 95% confidence interval: 1.12–2.27) compared with the other genotypes (GT + GG). PD patients demonstrate a similar genotypic and allelic frequency in BST1 rs11724635, HLA-DQB1 rs9275326, and SPPL2B rs62120679 compared with controls. These findings suggested that the STK39 rs1955337 TT genotype is a risk factor for Han-Chinese patients with PD in Taiwan. The ethnic discrepancies of the other 3 genetic variants may indicate a distinct genetic background of neuroinflammation between PD patients in Han-Chinese and Caucasians. PMID:26469904

Novel HLA class I associations with HIV-1 control in a unique genetically admixed population.

PubMed

Valenzuela-Ponce, Humberto; Alva-Hernández, Selma; Garrido-Rodríguez, Daniela; Soto-Nava, Maribel; García-Téllez, Thalía; Escamilla-Gómez, Tania; García-Morales, Claudia; Quiroz-Morales, Verónica Sonia; Tapia-Trejo, Daniela; Del Arenal-Sánchez, Silvia; Prado-Galbarro, Francisco-Javier; Hernández-Juan, Ramón; Rodríguez-Aguirre, Edna; Murakami-Ogasawara, Akio; Mejía-Villatoro, Carlos; Escobar-Urias, Ingrid Y; Pinzón-Meza, Rodolfo; Pascale, Juan Miguel; Zaldivar, Yamitzel; Porras-Cortés, Guillermo; Quant-Durán, Carlos; Lorenzana, Ivette; Meza, Rita I; Palou, Elsa Y; Manzanero, Marvin; Cedillos, Rolando A; Aláez, Carmen; Brockman, Mark A; Harrigan, P Richard; Brumme, Chanson J; Brumme, Zabrina L; Ávila-Ríos, Santiago; Reyes-Terán, Gustavo

2018-04-17

Associations between HLA class I alleles and HIV progression in populations exhibiting Amerindian and Caucasian genetic admixture remain understudied. Using univariable and multivariable analyses we evaluated HLA associations with five HIV clinical parameters in 3,213 HIV clade B-infected, ART-naïve individuals from Mexico and Central America (MEX/CAM cohort). A Canadian cohort (HOMER, n = 1622) was used for comparison. As expected, HLA allele frequencies in MEX/CAM and HOMER differed markedly. In MEX/CAM, 13 HLA-A, 24 HLA-B, and 14 HLA-C alleles were significantly associated with at least one clinical parameter. These included previously described protective (e.g. B*27:05, B*57:01/02/03 and B*58:01) and risk (e.g. B*35:02) alleles, as well as novel ones (e.g. A*03:01, B*15:39 and B*39:02 identified as protective, and A*68:03/05, B*15:30, B*35:12/14, B*39:01/06, B*39:05~C*07:02, and B*40:01~C*03:04 identified as risk). Interestingly, both protective (e.g. B*39:02) and risk (e.g. B*39:01/05/06) subtypes were identified within the common and genetically diverse HLA-B*39 allele group, characteristic to Amerindian populations. While HLA-HIV associations identified in MEX and CAM separately were similar overall (Spearman's rho = 0.33, p = 0.03), region-specific associations were also noted. The identification of both canonical and novel HLA/HIV associations provides a first step towards improved understanding of HIV immune control among unique and understudied Mestizo populations.

STS-87 crew in LC-39B white room during TCDT

NASA Technical Reports Server (NTRS)

1997-01-01

The crew of the STS-87 mission, scheduled for launch Nov. 19 aboard the Space Shuttle Columbia from pad 39B at Kennedy Space Center (KSC), participates in the Terminal Countdown Demonstration Test (TCDT) at KSC. Standing, from left, Mission Specialist Winston Scott; Backup Payload Specialist Yaroslav Pustovyi, Ph.D., of the National Space Agency of Ukraine (NSAU); Payload Specialist Leonid Kadenyuk of NSAU; Pilot Steven Lindsey; Commander Kevin Kregel; Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan; and Mission Specialist Kalpana Chawla, Ph.D. The TCDT is held at KSC prior to each Space Shuttle flight providing the crew of each mission opportunities to participate in simulated countdown activities. The TCDT ends with a mock launch countdown culminating in a simulated main engine cut-off. The crew also spends time undergoing emergency egress training exercises at the pad and has an opportunity to view and inspect the payloads in the orbiter's payload bay.

Replicas of the Santa Maria, Nina, Pinta sail by OV-105 on KSC LC Pad 39B

NASA Image and Video Library

1992-05-06

S92-39074 (6 May 1992) --- The centuries-old technology that built Christopher Columbus' three sailing ships passes within a half mile of the 20th-Century Space Shuttle Endeavour, in background, awaiting liftoff on Launch Pad 39B. The replicas of the Santa Maria, Nina, and Pinta wind-powered ships, managed by the Spain '92 Foundation, are on a tour to ports around the Gulf of Mexico and up the Atlantic Coast of the United States. Endeavour is set to lift off on its maiden voyage, STS-49, on May 7, 1992. Video footage of the two types of exploration vessels will be used by NASA for a variety of productions, including the annual Von Braun Exploration forum sponsored by NASA's Marshall Space Flight Center (MSFC), Huntsville, Alabama, in October, 1992. This year's theme is Exploration and the Evolution of Nations. 1992 is the 500th anniversary of Columbus' voyage to the New World.

STS-87 Payload installation in LC 39B PCR

NASA Technical Reports Server (NTRS)

1997-01-01

A payload canister, seen here half-open, containing the primary payloads for the STS-87 mission, is moved into the Payload Changeout Room at Pad 39B at Kennedy Space Center. The STS-87 payload includes the United States Microgravity Payload-4 (USMP- 4), seen here on two Multi-Purpose Experiment Support Structures in the center of the photo, and Spartan-201, wrapped in a protective covering directly above the USMP-4 experiments. Spartan-201 is a small retrievable satellite involved in research to study the interaction between the Sun and its wind of charged particles. USMP-4 is one of a series of missions designed to conduct scientific research aboard the Shuttle in the unique microgravity environment for extended periods of time. In the past, USMP missions have provided invaluable experience in the design of instruments needed for the International Space Station (ISS) and microgravity programs to follow in the 21st century. STS-87 is scheduled for launch Nov. 19.

STS-55 Columbia, OV-102, mated to ET and SRBs, heads to KSC LC during rollout

NASA Technical Reports Server (NTRS)

1993-01-01

German payload processing team members watch as STS-55 Columbia, Orbiter Vehicle (OV) 102, mated to the external tank (ET) and solid rocket boosters (SRBs), heads to Kennedy Space Center (KSC) Launch Complex (LC) Pad 39A. OV-102, the ET, and SRBs ride atop the mobile launch platform and the crawler transporter. A spectator in the foreground is wearing an STS-55 t-shirt. The German-managed Spacelab Deutsche 2 (SL-D2) and the Unique Support Structure (USS) are already integrated in OV-102's payload bay as it makes its way to LC Pad 39A. OV-102 is targeted for liftoff on Space Shuttle Mission STS-55 in late February. View provided by KSC with alternate KSC number KSC-93PC-283.

Mutations in RAB39B cause X-linked intellectual disability and early-onset Parkinson disease with α-synuclein pathology.

PubMed

Wilson, Gabrielle R; Sim, Joe C H; McLean, Catriona; Giannandrea, Maila; Galea, Charles A; Riseley, Jessica R; Stephenson, Sarah E M; Fitzpatrick, Elizabeth; Haas, Stefan A; Pope, Kate; Hogan, Kirk J; Gregg, Ronald G; Bromhead, Catherine J; Wargowski, David S; Lawrence, Christopher H; James, Paul A; Churchyard, Andrew; Gao, Yujing; Phelan, Dean G; Gillies, Greta; Salce, Nicholas; Stanford, Lynn; Marsh, Ashley P L; Mignogna, Maria L; Hayflick, Susan J; Leventer, Richard J; Delatycki, Martin B; Mellick, George D; Kalscheuer, Vera M; D'Adamo, Patrizia; Bahlo, Melanie; Amor, David J; Lockhart, Paul J

2014-12-04

Advances in understanding the etiology of Parkinson disease have been driven by the identification of causative mutations in families. Genetic analysis of an Australian family with three males displaying clinical features of early-onset parkinsonism and intellectual disability identified a ∼45 kb deletion resulting in the complete loss of RAB39B. We subsequently identified a missense mutation (c.503C>A [p.Thr168Lys]) in RAB39B in an unrelated Wisconsin kindred affected by a similar clinical phenotype. In silico and in vitro studies demonstrated that the mutation destabilized the protein, consistent with loss of function. In vitro small-hairpin-RNA-mediated knockdown of Rab39b resulted in a reduction in the density of α-synuclein immunoreactive puncta in dendritic processes of cultured neurons. In addition, in multiple cell models, we demonstrated that knockdown of Rab39b was associated with reduced steady-state levels of α-synuclein. Post mortem studies demonstrated that loss of RAB39B resulted in pathologically confirmed Parkinson disease. There was extensive dopaminergic neuron loss in the substantia nigra and widespread classic Lewy body pathology. Additional pathological features included cortical Lewy bodies, brain iron accumulation, tau immunoreactivity, and axonal spheroids. Overall, we have shown that loss-of-function mutations in RAB39B cause intellectual disability and pathologically confirmed early-onset Parkinson disease. The loss of RAB39B results in dysregulation of α-synuclein homeostasis and a spectrum of neuropathological features that implicate RAB39B in the pathogenesis of Parkinson disease and potentially other neurodegenerative disorders. Copyright © 2014 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

STS-28 Columbia, OV-102, crewmembers leave KSC O&C Bldg en route to LC Pad 39

NASA Image and Video Library

1989-08-08

STS028-S-002 (8 Aug 1989) --- The five astronaut crewmembers for STS-28 leave the Operations and Checkout (O&C) Building to board a transfer van en route to Launch Complex 39 for a date with Columbia. Left to right are Astronauts Mark N. Brown, James C. Adamson, David C. Leestma, Richard N. Richards and Brewster H. Shaw Jr.

KSC-2010-5868

NASA Image and Video Library

2010-12-17

CAPE CANAVERAL, Fla. -- Launch Complex 39 is seen across brackish water as the sun rises at NASA's Kennedy Space Center in Florida. On the left is Launch Pad 39B, which is being restructured for future use. On the right is Launch Pad 39A, where space shuttle Discovery is being prepared for a tanking test. Kennedy coexists with the Merritt Island National Wildlife Refuge, habitat to more than 310 species of birds, 25 mammals, 117 fish and 65 amphibians and reptiles. Photo credit: NASA/Frank Michaux

78 FR 62594 - 36(b)(1) Arms Sales Notification

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-22

... Consideration for Purchase: 5000 GBU-39/B Small Diameter Bombs (SDB) with BRU-61 carriage systems, 8 SDB Guided... Emirates has requested a possible sale of 5000 GBU-39/B Small Diameter Bombs (SDB) with BRU-61 carriage... environmental conditions. 5. The GBU-39/B Small Diameter Bomb (SDB) I weapon is a 250-lb class, all-up round...

KSC-2014-2615

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- A crawler-transporter rolls toward Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move Mobile Launcher Platform-2, or MLP-2, from the pad to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2622

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- A crawler-transporter carries Mobile Launcher Platform-2, or MLP-2, away from Launch Pad 39A at NASA's Kennedy Space Center in Florida. The MLP is being moved to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

Efficacy of essential oils from edible plants as insecticides against the house fly, Musca domestica L.

PubMed

Palacios, Sara M; Bertoni, Alberto; Rossi, Yanina; Santander, Rocío; Urzúa, Alejandro

2009-05-25

The compositions of 12 essential oils (EOs) obtained by hydrodistillation of edible fruits and herbs were analyzed by gas chromatography/mass spectroscopy (GC/MS). The insecticidal activity of each oil against the house fly Musca domestica was evaluated by placing flies in a glass jar with a screw cap that held a piece of EO-treated cotton yarn. The dose necessary to kill 50% of flies (LC(50)) in 30 min was determined at 26 +/- 1 degrees C. Twelve EOs and 17 individual terpenes were assayed against M. domestica, showing LC(50) values ranging from 3.9 to 85.2 and from 3.3 to >100 mg/dm(3), respectively. EO from Citrus sinensis was the most potent insecticide (LC(50 )= 3.9 mg/dm(3)), followed by EOs from C. aurantium (LC(50 )= 4.8 mg/dm(3)) and Eucalyptus cinerea (LC(50 )= 5.5 mg/dm(3)). According to GC/MS analysis, limonene (92.47%), linalool (1.43%), and b-myrcene (0.88%) were the principal components of C. sinensis EO. Limonene was also the principal constituent (94.07%) of C. aurantium, while 1,8-cineole (56.86%) was the major constituent of E. cinerea EO. 1,8-Cineole was most active against M. domestica (LC(50 )= 3.3 mg/dm(3)), while (4R)(+)-limonene, was moderately active (LC(50 )= 6.2 mg/dm(3)). Dimethyl 2,2-dichlorovinyl phosphate (DDVP) selected as a positive control, showed an LC(50) of 0.5 mg/dm(3). EOs from C. sinensis, C. aurantium, and E. cinerea show promise as natural insecticides against houseflies.

Prevalence and Toxin Characteristics of Bacillus thuringiensis Isolated from Organic Vegetables.

PubMed

Kim, Jung-Beom; Choi, Ok-Kyung; Kwon, Sun-Mok; Cho, Seung-Hak; Park, Byung-Jae; Jin, Na Young; Yu, Yong Man; Oh, Deog-Hwan

2017-08-28

The prevalence and toxin characteristics of Bacillus thuringiensis isolated from 39 organic vegetables were investigated. B. thuringiensis was detected in 30 out of the 39 organic vegetables (76.9%) with a mean value of 2.60 log CFU/g. Twenty-five out of the 30 B. thuringiensis isolates (83.3%) showed insecticidal toxicity against Spodoptera exigua . The hblCDA, nheABC , and entFM genes were found to be the major toxin genes, but the ces gene was not detected in any of the tested B. thuringiensis isolates. The hemolysin BL enterotoxin was detected in all 30 B. thuringiensis isolates (100%). The non-hemolytic enterotoxin complex was found in 27 out of 30 B. thuringiensis isolates (90.0%). The B. thuringiensis tested in this study had similar toxin gene characteristics to B. cereus , which possessed more than one toxin gene. B. thuringiensis could have the potential risk of foodborne illness based on the toxin genes and toxin-producing ability.

27 CFR 21.39 - Formula No. 6-B.

Code of Federal Regulations, 2012 CFR

2012-04-01

... OF THE TREASURY LIQUORS FORMULAS FOR DENATURED ALCOHOL AND RUM Specially Denatured Spirits Formulas and Authorized Uses § 21.39 Formula No. 6-B. (a) Formula. To every 100 gallons of alcohol add: One... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Formula No. 6-B. 21.39...

27 CFR 21.39 - Formula No. 6-B.

Code of Federal Regulations, 2014 CFR

2014-04-01

... OF THE TREASURY ALCOHOL FORMULAS FOR DENATURED ALCOHOL AND RUM Specially Denatured Spirits Formulas and Authorized Uses § 21.39 Formula No. 6-B. (a) Formula. To every 100 gallons of alcohol add: One... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Formula No. 6-B. 21.39...

27 CFR 21.39 - Formula No. 6-B.

Code of Federal Regulations, 2013 CFR

2013-04-01

... OF THE TREASURY ALCOHOL FORMULAS FOR DENATURED ALCOHOL AND RUM Specially Denatured Spirits Formulas and Authorized Uses § 21.39 Formula No. 6-B. (a) Formula. To every 100 gallons of alcohol add: One... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Formula No. 6-B. 21.39...

75 FR 68291 - Approval and Promulgation of State Implementation Plans; Texas; Revisions to Chapters 39, 55, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-05

... rest of 30 TAC 39.418 and the cross-referenced 30 TAC 39.411(b) from EPA's consideration on July 2... substance and context to these three subsections. Further, these three subsections fit numerically into the... 39.418 and the cross-referenced 30 TAC 39.411(b) are also contained in the July 2010 submission. Thus...

STS-95 Space Shuttle Discovery rollout to Launch Pad 39B

NASA Technical Reports Server (NTRS)

1998-01-01

Perched on the Mobile Launch Platform, in the early morning hours Space Shuttle Discovery approaches Launch Complex Pad 39B after a 6-hour, 4.2-mile trip from the Vehicle Assembly Building. At the launch pad, the orbiter, external tank and solid rocket boosters will undergo final preparations for the launch, scheduled to lift off Oct. 29. The mission includes research payloads such as the Spartan solar-observing deployable spacecraft, the Hubble Space Telescope Orbital Systems Test Platform, the International Extreme Ultraviolet Hitchhiker, as well as the SPACEHAB single module with experiments on space flight and the aging process.

Crystallization and preliminary crystallographic analysis of human Atg4B–LC3 complex

DOE Office of Scientific and Technical Information (OSTI.GOV)

Satoo, Kenji; Suzuki, Nobuo N.; Fujioka, Yuko

2007-02-01

Human Atg4B and LC3 were expressed, purified and crystallized as a complex. Diffraction data were collected to a resolution of 1.9 Å. The reversible modification of Atg8 with phosphatidylethanolamine (PE) is crucial for autophagy, the bulk degradation process of cytoplasmic components by the vacuolar/lysosomal system. Atg4 is a cysteine protease that is responsible for the processing and deconjugation of Atg8. Human Atg4B (HsAtg4B; a mammalian orthologue of yeast Atg4) and LC3 (a mammalian orthologue of yeast Atg8) were expressed and purified and two complexes, one consisting of HsAtg4B(1–354) and LC3(1–120) (complex I; the product complex) and the other consisting ofmore » HsAtg4B(1–354) and LC3(1–124) (complex II; the substrate complex), were crystallized using polyethylene glycol 3350 as a precipitant. In both complexes His280 of HsAtg4B was mutated to alanine. The crystals belong to the same space group P2{sub 1}2{sub 1}2{sub 1}, with unit-cell parameters a = 47.5, b = 91.8, c = 102.6 Å for complex I and a = 46.9, b = 90.9, c = 102.5 Å for complex II. Diffraction data were collected to a resolution of 1.9 Å from both crystals.« less

An Ambipolar BODIPY Derivative for a White Exciplex OLED and Cholesteric Liquid Crystal Laser toward Multifunctional Devices.

PubMed

Chapran, Marian; Angioni, Enrico; Findlay, Neil J; Breig, Benjamin; Cherpak, Vladyslav; Stakhira, Pavlo; Tuttle, Tell; Volyniuk, Dmytro; Grazulevicius, Juozas V; Nastishin, Yuriy A; Lavrentovich, Oleg D; Skabara, Peter J

2017-02-08

A new interface engineering method is demonstrated for the preparation of an efficient white organic light-emitting diode (WOLED) by embedding an ultrathin layer of the novel ambipolar red emissive compound 4,4-difluoro-2,6-di(4-hexylthiopen-2-yl)-1,3,5,7,8-pentamethyl-4-bora-3a,4a-diaza-s-indacene (bThBODIPY) in the exciplex formation region. The compound shows a hole and electron mobility of 3.3 × 10 -4 and 2 × 10 -4 cm 2 V -1 s -1 , respectively, at electric fields higher than 5.3 × 10 5 V cm -1 . The resulting WOLED exhibited a maximum luminance of 6579 cd m -2 with CIE 1931 color coordinates (0.39; 0.35). The bThBODIPY dye is also demonstrated to be an effective laser dye for a cholesteric liquid crystal (ChLC) laser. New construction of the ChLC laser, by which a flat capillary with an optically isotropic dye solution is sandwiched between two dye-free ChLC cells, provides photonic lasing at a wavelength well matched with that of a dye-doped planar ChLC cell.

46 CFR 39.20-9 - Tank barge liquid overfill protection-B/ALL.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Section 39.20-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS VAPOR CONTROL SYSTEMS Design and Equipment § 39.20-9 Tank barge liquid overfill protection—B/ALL. Each cargo tank of a tank...-57 and 501-12; and (iii) § 111.105-9 of this chapter. (b) An intrinsically safe overfill control...

46 CFR 39.20-9 - Tank barge liquid overfill protection-B/ALL.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Section 39.20-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS VAPOR CONTROL SYSTEMS Design and Equipment § 39.20-9 Tank barge liquid overfill protection—B/ALL. Each cargo tank of a tank...-57 and 501-12; and (iii) § 111.105-9 of this chapter. (b) An intrinsically safe overfill control...

46 CFR 39.20-9 - Tank barge liquid overfill protection-B/ALL.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 39.20-9 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS VAPOR CONTROL SYSTEMS Design and Equipment § 39.20-9 Tank barge liquid overfill protection—B/ALL. Each cargo tank of a tank...-57 and 501-12; and (iii) § 111.105-9 of this chapter. (b) An intrinsically safe overfill control...

Detection and quantification of new psychoactive substances (NPSs) within the evolved "legal high" product, NRG-2, using high performance liquid chromatography-amperometric detection (HPLC-AD).

PubMed

Zuway, Khaled Y; Smith, Jamie P; Foster, Christopher W; Kapur, Nikil; Banks, Craig E; Sutcliffe, Oliver B

2015-09-21

The global increase in the production and abuse of cathinone-derived New Psychoactive Substances (NPSs) has developed the requirement for rapid, selective and sensitive protocols for their separation and detection. Electrochemical sensing of these compounds has been demonstrated to be an effective method for the in-field detection of these substances, either in their pure form or in the presence of common adulterants, however, the technique is limited in its ability to discriminate between structurally related cathinone-derivatives (for example: (±)-4′-methylmethcathinone (4-MMC, 2a) and (±)-4′-methyl-N-ethylmethcathinone (4-MEC, 2b) when they are both present in a mixture. In this paper we demonstrate, for the first time, the combination of HPLC-UV with amperometric detection (HPLC-AD) for the qualitative and quantitative analysis of 4-MMC and 4-MEC using either a commercially available impinging jet (LC-FC-A) or custom-made iCell channel (LC-FC-B) flow-cell system incorporating embedded graphite screen-printed macroelectrodes. The protocol offers a cost-effective, reproducible and reliable sensor platform for the simultaneous HPLC-UV and amperometric detection of the target analytes. The two systems have similar limits of detection, in terms of amperometric detection [LC-FC-A: 14.66 μg mL(-1) (2a) and 9.35 μg mL(-1) (2b); LC-FC-B: 57.92 μg mL(-1) (2a) and 26.91 μg mL(-1) (2b)], to the previously reported oxidative electrochemical protocol [39.8 μg mL(-1) (2a) and 84.2 μg mL(-1) (2b)], for two synthetic cathinones, prevalent on the recreational drugs market. Though not as sensitive as standard HPLC-UV detection, both flow cells show a good agreement, between the quantitative electroanalytical data, thereby making them suitable for the detection and quantification of 4-MMC and 4-MEC, either in their pure form or within complex mixtures. Additionally, the simultaneous HPLC-UV and amperometric detection protocol detailed herein shows a marked improvement and advantage over previously reported electroanalytical methods, which were either unable to selectively discriminate between structurally related synthetic cathinones (e.g. 4-MMC and 4-MEC) or utilised harmful and restrictive materials in their design.

A High-Throughput Screening Method to Identify Potential Pesticides for Mosquito Control

DTIC Science & Technology

2009-01-01

receptor agonists 5 Imidacloprid Nicotinic acetylcholine receptor agonist/antagonists 4 Diazinon Acetylcholinesterase inhibitors (organophosphates) 1B...0.84) 1.50 Spinosad 3.9 101 (3.6 101Ð4.1 101) 6.3 101 (5.5 101Ð7.9 101) 7.82 (1.33) 2.95 Imidacloprid 3.7 101 (2.9 101Ð4.5 101...pesticides (pyridaben, hydramethylnon, imidacloprid , diazinon, and indoxacarb) were moder- ately active against Þrst-instar larvae,withLC50 values of

A New Comprehensive Lightning Instrumentation System for Pad 39B at the Kennedy Space Center, Florida

NASA Technical Reports Server (NTRS)

Mata, Carlos T.; Rakov, Vladimir A.; Mata, Angel G.; Bonilla Tatiana; Navedo, Emmanuel; Snyder, Gary P.

2010-01-01

A new comprehensive lightning instrumentation system has been designed for Launch Complex 39B at the Kennedy Space Center, Florida. This new instrumentation system includes the synchronized recording of six high-speed video cameras, currents through the nine downconductors of the new lightning protection system, four B-dot, 3-axis measurement stations, and five D-dot stations composed of two antennas each. The instrumentation system is composed of centralized transient recorders and digitizers that located close to the sensors in the field. The sensors and transient recorders communicate via optical fiber. The transient recorders are triggered by the B-dot sensors, the E-dot sensors, or the current through the downlead conductors. The high-speed cameras are triggered by the transient recorders when the latter perceives a qualified trigger.

DETAIL VIEW OF SRB/ET ACCESS PANELS, THROUGH VEHICLE ACCESS PLATFORMS ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL VIEW OF SRB/ET ACCESS PANELS, THROUGH VEHICLE ACCESS PLATFORMS E-NORTH, E-SOUTH, B-NORTH, AND B-SOUTH, HB-3, FACING NORTH - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

Complexity and Chaos - State-of-the-Art; List of Works, Experts, Organizations, Projects, Journals, Conferences and Tools

DTIC Science & Technology

2007-09-01

Adaptive Systems............................................. 64 3.9 Connectivity and Communication in Complex Adaptive Systems...450 3.10.6 Human Factors: Perception, Comprehension, Communication and Collaboration...288 B.9 Catastrophe, Conflict, Crisis

STS-87 crew in front of LC-39B during TCDT

NASA Technical Reports Server (NTRS)

1997-01-01

The crew of the STS-87 mission, scheduled for launch Nov. 19 aboard the Space Shuttle Columbia from Pad 39B at Kennedy Space Center (KSC), poses at the pad during a break in the Terminal Countdown Demonstration Test (TCDT) at KSC. Standing in front of the Shuttle Columbia are, from left, Commander Kevin Kregel; Mission Specialist Kalpana Chawla, Ph.D.; Pilot Steven Lindsey; Mission Specialist Takao Doi, Ph.D., of the National Space Development Agency of Japan; Backup Payload Specialist Yaroslav Pustovyi, Ph.D., of the National Space Agency of Ukraine (NSAU); Payload Specialist Leonid Kadenyuk of NSAU; and Mission Specialist Winston Scott. The TCDT is held at KSC prior to each Space Shuttle flight providing the crew of each mission opportunities to participate in simulated countdown activities. The TCDT ends with a mock launch countdown culminating in a simulated main engine cut-off. The crew also spends time undergoing emergency egress training exercises at the pad and has an opportunity to view and inspect the payloads in the orbiter's payload bay.

25 CFR 39.143 - What is a small high school?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false What is a small high school? 39.143 Section 39.143... PROGRAM Indian School Equalization Formula Small School Adjustment § 39.143 What is a small high school? For purposes of this part, a small high school: (a) Is accredited under 25 U.S.C. 2001(b); (b) Is...

25 CFR 39.143 - What is a small high school?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false What is a small high school? 39.143 Section 39.143... PROGRAM Indian School Equalization Formula Small School Adjustment § 39.143 What is a small high school? For purposes of this part, a small high school: (a) Is accredited under 25 U.S.C. 2001(b); (b) Is...

25 CFR 39.143 - What is a small high school?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 25 Indians 1 2013-04-01 2013-04-01 false What is a small high school? 39.143 Section 39.143... PROGRAM Indian School Equalization Formula Small School Adjustment § 39.143 What is a small high school? For purposes of this part, a small high school: (a) Is accredited under 25 U.S.C. 2001(b); (b) Is...

25 CFR 39.143 - What is a small high school?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 25 Indians 1 2012-04-01 2011-04-01 true What is a small high school? 39.143 Section 39.143 Indians... Indian School Equalization Formula Small School Adjustment § 39.143 What is a small high school? For purposes of this part, a small high school: (a) Is accredited under 25 U.S.C. 2001(b); (b) Is staffed with...

25 CFR 39.143 - What is a small high school?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 25 Indians 1 2014-04-01 2014-04-01 false What is a small high school? 39.143 Section 39.143... PROGRAM Indian School Equalization Formula Small School Adjustment § 39.143 What is a small high school? For purposes of this part, a small high school: (a) Is accredited under 25 U.S.C. 2001(b); (b) Is...

STS-65 Columbia, OV-102, lifts off from KSC LC Pad 39A

NASA Technical Reports Server (NTRS)

1994-01-01

Columbia, Orbiter Vehicle (OV) 102, begins its roll maneuver after clearing the fixed service structure (FSS) tower as it rises above Kennedy Space Center (KSC) Launch Complex (LC) Pad 39A. In the foreground of this horizontal scene is Florida brush and a waterway. Beyond the brush, the shuttle's exhaust cloud envelops the immediate launch pad area. Launch occurred at 12:43 pm Eastern Daylight Time (EDT). The glow of the space shuttle main engine (SSME) and solid rocket booster (SRB) firings is reflected in the nearby waterway. Once in Earth orbit, STS-65's six NASA astronauts and a Japanese Payload Specialist aboard OV-102 will begin two weeks of experimentation in support of the second International Microgravity Laboratory (IML-2).

STS-65 Columbia, OV-102, clears launch tower after liftoff from KSC LC 39A

NASA Technical Reports Server (NTRS)

1994-01-01

Columbia, Orbiter Vehicle (OV) 102, heads skyward after clearing the fixed service structure (FSS) tower at Kennedy Space Center (KSC) Launch Complex (LC) Pad 39A. Florida plant life appears in the foreground. The exhaust cloud produced by OV-102's solid rocket boosters (SRBs) covers the launch pad area with the exception of the sound suppression water system tower. OV-102's starboard side and the right SRB are visible from this angle. Launch occurred at 12:43 pm Eastern Daylight Time (EDT). Once in Earth orbit, STS-65's six NASA astronauts and a Japanese Payload Specialist aboard OV-102 will begin two weeks of experimentation in support of the second International Microgravity Laboratory (IML-2).

STS-65 Columbia, OV-102, rises above KSC LC Pad 39A during liftoff

NASA Technical Reports Server (NTRS)

1994-01-01

Columbia, Orbiter Vehicle (OV) 102, rises above Kennedy Space Center (KSC) Launch Complex (LC) Pad 39A after liftoff at 12:43 pm Eastern Daylight Time (EDT). An exhaust cloud covers the launch pad area and the glow of the space shuttle main engine (SSME) and solid rocket booster (SRB) firings is reflected in a nearby marsh as OV-102 atop its external tank (ET) heads toward Earth orbit. A small flock of birds is visible at the right. Once in Earth's orbit, STS-65's six NASA astronauts and a Japanese Payload Specialist aboard OV-102 will begin two weeks of experimentation in support of the second International Microgravity Laboratory (IML-2) mission.

STS-65 Columbia, OV-102, lifts off from KSC LC Pad 39A

NASA Image and Video Library

1994-07-08

Columbia, Orbiter Vehicle (OV) 102, begins its roll maneuver after clearing the fixed service structure (FSS) tower as it rises above Kennedy Space Center (KSC) Launch Complex (LC) Pad 39A. In the foreground of this horizontal scene is Florida brush and a waterway. Beyond the brush, the shuttle's exhaust cloud envelops the immediate launch pad area. Launch occurred at 12:43 pm Eastern Daylight Time (EDT). The glow of the space shuttle main engine (SSME) and solid rocket booster (SRB) firings is reflected in the nearby waterway. Once in Earth orbit, STS-65's six NASA astronauts and a Japanese Payload Specialist aboard OV-102 will begin two weeks of experimentation in support of the second International Microgravity Laboratory (IML-2).

STS-65 Columbia, OV-102, rises above KSC LC Pad 39A during liftoff

NASA Image and Video Library

1994-07-08

Columbia, Orbiter Vehicle (OV) 102, rises above Kennedy Space Center (KSC) Launch Complex (LC) Pad 39A after liftoff at 12:43 pm Eastern Daylight Time (EDT). An exhaust cloud covers the launch pad area and the glow of the space shuttle main engine (SSME) and solid rocket booster (SRB) firings is reflected in a nearby marsh as OV-102 atop its external tank (ET) heads toward Earth orbit. A small flock of birds is visible at the right. Once in Earth's orbit, STS-65's six NASA astronauts and a Japanese Payload Specialist aboard OV-102 will begin two weeks of experimentation in support of the second International Microgravity Laboratory (IML-2) mission.

STS-65 Columbia, OV-102, clears launch tower after liftoff from KSC LC 39A

NASA Image and Video Library

1994-07-08

Columbia, Orbiter Vehicle (OV) 102, heads skyward after clearing the fixed service structure (FSS) tower at Kennedy Space Center (KSC) Launch Complex (LC) Pad 39A. Florida plant life appears in the foreground. The exhaust cloud produced by OV-102's solid rocket boosters (SRBs) covers the launch pad area with the exception of the sound suppression water system tower. OV-102's starboard side and the right SRB are visible from this angle. Launch occurred at 12:43 pm Eastern Daylight Time (EDT). Once in Earth orbit, STS-65's six NASA astronauts and a Japanese Payload Specialist aboard OV-102 will begin two weeks of experimentation in support of the second International Microgravity Laboratory (IML-2).

75 FR 18446 - Airworthiness Directives; The Boeing Company Model 747-100, 747-100B, 747-100B SUD, 747-200B, 747...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-12

... assemblies in the ECS with burned Boeing Material Specification (BMS) 8-39 polyurethane foam insulation. This... duct assemblies in the ECS wrapped with BMS 8-39 polyurethane foam insulation, a material of which the... electrical arc from igniting the BMS 8-39 polyurethane foam insulation on the duct assemblies of the ECS...

FILMING OF 'CONTACT' AT LC39 PRESS SITE

NASA Technical Reports Server (NTRS)

1997-01-01

Warner Bros.' cast and crew are filming scenes for the movie 'Contact' at Kennedy Space Center's Launch Complex 39 Press Site on January 30. The screenplay for 'Contact' is based on the best- selling novel by the late astronomer Carl Sagan. The cast includes Jodie Foster, Matthew McConaughey, John Hurt, James Woods, Tom Skerritt, David Morse, William Fichtner, Rob Lowe and Angela Bassett. Described by Warner Bros. as a science fiction drama, 'Contact' will depict humankind's first encounter with evidence of extraterrestrial life.

FILMING OF 'CONTACT' AT LC39 PRESS SITE

NASA Technical Reports Server (NTRS)

1997-01-01

Warner Bros.' cast and crew are filming scenes for the movie 'Contact' at Kennedy Space Center's Launch Complex 39 Press Site on January 29. The screenplay for 'Contact' is based on the best- selling novel by the late astronomer Carl Sagan. The cast includes Jodie Foster, Matthew McConaughey, John Hurt, James Woods, Tom Skerritt, David Morse, William Fichtner, Rob Lowe and Angela Bassett. Described by Warner Bros. as a science fiction drama, 'Contact' will depict humankind's first encounter with evidence of extraterrestrial life.

39 CFR 3010.2 - Types of rate adjustments for market dominant products.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., authorized under 39 U.S.C. 3622(d)(1)(E), is based on exigent circumstances. (b) Upon the establishment of... adjustment, authorized under 39 U.S.C. 3622(d)(1)(D), is based on the statutory annual limitation. A Type 1-B rate adjustment, authorized under 39 U.S.C. 3622(d)(2)(C), is based on an exception to the annual...

KSC-2014-2617

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- A crawler-transporter begins its climb toward Mobile Launcher Platform-2, or MLP-2, on the hardstand at Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move the MLP to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2623

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- The flame trench comes into view on Launch Pad 39A as a crawler-transporter hauls Mobile Launcher Platform-2, or MLP-2, off the pad at NASA's Kennedy Space Center in Florida. The MLP is being moved to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2619

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- A crawler-transporter nears the Mobile Launcher Platform-2, or MLP-2, positioned over the flame trench at Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move the MLP to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2616

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- A crawler-transporter begins its climb to the hardstand at Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move Mobile Launcher Platform-2, or MLP-2, from the pad to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2618

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- A crawler-transporter creeps toward Mobile Launcher Platform-2, or MLP-2, on the hardstand at Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move the MLP to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2620

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- A crawler-transporter rolls under the Mobile Launcher Platform-2, or MLP-2, positioned over the flame trench at Launch Pad 39A at NASA's Kennedy Space Center in Florida. Operations are underway to move the MLP to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2624

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, Mobile Launcher Platform-2, or MLP-2, rolling away from Launch Pad 39A atop a crawler-transporter, was positioned over the pad's flame trench only moments before. The MLP is being moved to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2621

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, a truck sprays water along the crawlerway to reduce dust ahead of the crawler-transporter moving Mobile Launcher Platform-2, or MLP-2, from Launch Pad 39A to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2626

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, a truck sprays water along the crawlerway to reduce dust ahead of the crawler-transporter moving Mobile Launcher Platform-2, or MLP-2, from Launch Pad 39A, in the background, to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-2014-2627

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- The crawler-transporter transporting Mobile Launcher Platform-2, or MLP-2, from Launch Pad 39A creeps along the crawlerway toward the Vehicle Assembly Building, or VAB, at NASA's Kennedy Space Center in Florida. The MLP is being moved to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

KSC-04pd0659

NASA Image and Video Library

2004-03-26

CAPE CANAVERAL, Fla. -- This aerial photo shows the expanse of the Launch Complex 39 Area, bordered at the top by the Atlantic and a cloud-filled sky. At center right, towering above the surrounding sites, is the Vehicle Assembly Building. To the left is the Orbiter Processing Facility's Bay 3. In the foreground are OPF Bays 1 and 2. The two-lane crawlerway stretches from the VAB toward the coast, site of Launch Pad 39A, closest, and Launch Pad 39B, far left. Between the VAB and the ocean sprawl the Banana Creek and the Banana River. Photo credit: NASA

Simultaneous Determination of Total Vitamins B1, B2, B3, and B6 in Infant Formula and Related Nutritionals by Enzymatic Digestion and LC-MS/MS: Single-Laboratory Validation, First Action 2015.14.

PubMed

Salvati, Louis M; McClure, Sean C; Reddy, Todime M; Cellar, Nicholas A

2016-05-01

This method provides simultaneous determination of total vitamins B1, B2, B3, and B6 in infant formula and related nutritionals (adult and infant). The method was given First Action for vitamins B1, B2, and B6, but not B3, during the AOAC Annual Meeting in September 2015. The method uses acid phosphatase to dephosphorylate the phosphorylated vitamin forms. It then measures thiamine (vitamin B1); riboflavin (vitamin B2); nicotinamide and nicotinic acid (vitamin B3); and pyridoxine, pyridoxal, and pyridoxamine (vitamin B6) from digested sample extract by liquid chromatography-tandem mass spectrometry. A single-laboratory validation was performed on 14 matrixes provided by the AOAC Stakeholder Panel on Infant Formula and Adult Nutritionals (SPIFAN) to demonstrate method effectiveness. The method met requirements of the AOAC SPIFAN Standard Method Performance Requirement for each of the three vitamins, including average over-spike recovery of 99.6 ± 3.5%, average repeatability of 1.5 ± 0.8% relative standard deviation, and average intermediate precision of 3.9 ± 1.3% relative standard deviation.

75 FR 79988 - Airworthiness Directives; Eurocopter France Model AS350B, B1, B2, B3, BA, and EC130 B4 Helicopters

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-21

... Model AS350B, B1, B2, B3, BA, and EC130 B4 Helicopters AGENCY: Federal Aviation Administration (FAA..., 2009, for the Model AS350 B, BA, BB, B1, B2, and B3 helicopters (ASB 80.00.07); and ASB No. 80A003... authority delegated to me by the Administrator, the FAA proposes to amend 14 CFR part 39 as follows: PART 39...

STS-32 Columbia, OV-102, is positioned on the hard stand at KSC LC Pad 39A

NASA Image and Video Library

1989-11-28

S89-51983 (18 Nov 1989) --- Roll-out of the Space Shuttle Columbia is completed as the vehicle, atop the Mobile Launcher Platform, is positioned on the hard stand at Pad 39A. The approximately eight-hour journey from the Vehicle Assembly Building began at 2:32 a.m. EST. This marks the first time a Space Shuttle has been at Pad A at Launch Complex 39 since January 12, 1986, when Columbia was launched on mission 61C. Pad A will next be used for the launch of Columbia and a five person crew on the STS-32 mission, presently scheduled for no earlier than December 18, 1989.

Rare view of two space shuttles on adjacent KSC Launch Complex (LC) 39 pads

NASA Image and Video Library

1990-09-05

S90-48650 (5 Sept 1990) --- This rare view shows two space shuttles on adjacent pads at Launch Complex 39 with the Rotating Service Structures (RSR) retracted. Space Shuttle Columbia (foreground) is on Pad A where it awaits further processing for a September 6 early morning launch on STS-35. Discovery, its sister spacecraft, is set to begin preparations for an October liftoff on STS-41 when the Ulysses spacecraft is scheudled to be taxied into space. PLEASE NOTE: Following the taking of this photograph, STS-35 was postponed and STS-41's Discovery was successfully launched on Oct. 6.

Inhibition of the HDAC/Suv39/G9a pathway restores the expression of DNA damage-dependent major histocompatibility complex class I-related chain A and B in cancer cells.

PubMed

Nakajima, Nakako Izumi; Niimi, Atsuko; Isono, Mayu; Oike, Takahiro; Sato, Hiro; Nakano, Takashi; Shibata, Atsushi

2017-08-01

Immunotherapy is expected to be promising as a next generation cancer therapy. Immunoreceptors are often activated constitutively in cancer cells, however, such levels of ligand expression are not effectively recognized by the native immune system due to tumor microenvironmental adaptation. Studies have demonstrated that natural-killer group 2, member D (NKG2D), a major activating immunoreceptor, responds to DNA damage. The upregulation of major histocompatibility complex class I-related chain A and B (MICA/B) (members of NKG2D ligands) expression after DNA damage is associated with NK cell-mediated killing of cancer cells. However, the regulation of DNA damage-induced MICA/B expression has not been fully elucidated in the context of the types of cancer cell lines. In the present study, we found that MICA/B expression varied between cancer cell lines after DNA damage. Screening in terms of chromatin remodeling identified that inhibitors related to chromatin relaxation via post-translational modification on histone H3K9, i.e. HDAC, Suv39 or G9a inhibition, restored DNA damage-dependent MICA/B expression in insensitive cells. In addition, we revealed that the restored MICA/B expression was dependent on ATR as well as E2F1, a transcription factor. We further revealed that low‑dose treatment of an HDAC inhibitor was sufficient to restore MICA/B expression in insensitive cells. Finally, we demonstrated that HDAC inhibition restored DNA damage‑dependent cytotoxic NK activity against insensitive cells. Thus, the present study revealed that DNA damage‑dependent MICA/B expression in insensitive cancer cells can be restored by chromatin relaxation via the HDAC/Suv39/G9a pathway. Collectively, manipulation of chromatin status by therapeutic cancer drugs may potentiate the antitumor effect by enhancing immune activation following radiotherapy and DNA damage-associated chemotherapy.

Development of an AMS method to study oceanic circulation characteristics using cosmogenic 39Ar

USGS Publications Warehouse

Collon, P.H.; Bichler, M.; Caggiano, J.; Cecil, L.D.; El, Masri Y.; Golser, R.; Jiang, C.L.; Heinz, A.; Henderson, D.; Kutschera, W.; Lehmann, B.E.; Leleux, P.; Loosli, H.H.; Pardo, R.C.; Paul, M.; Rehm, K.E.; Schlosser, P.; Scott, R.H.; Smethie, W.M.; Vondrasek, R.

2004-01-01

Initial experiments at the ATLAS facility [Nucl. Instr. and Meth. B 92 (1994) 241] resulted in a clear detection of cosmogenic 39Ar signal at the natural level. The present paper summarizes the recent developments of 39Ar AMS measurements at ATLAS: the use of an electron cyclotron resonance (ECR) positive ion source equipped with a special quartz liner to reduce 39K background, the development of a gas handling system for small volume argon samples, the acceleration of 39Ar8+ ions to 232 MeV, and the final separation of 39Ar from 39K in a gas-filled spectrograph. The first successful AMS measurements of 39Ar in ocean water samples from the Southern Atlantic ventilation experiment (SAVE) are reported. Published by Elsevier B.V.

STS-33 Discovery, OV-103, early morning liftoff from KSC LC Pad 39B

NASA Image and Video Library

1989-11-22

STS033-S-003 (22 Nov 1989) --- The Space Shuttle Discovery heads for Earth-orbit on the first post-Challenger nocturnal launch. Liftoff occurred at 7:23:29:989 p.m. (EST), November 22, 1989. This picture shows almost a full front view of the Space Shuttle Discovery, its two Solid Rocket Boosters (SRB) and the External Tank (ET). Onboard for the Department of the Defense (DOD) devoted mission were astronauts Frederick D. Gregory, John E. Blaha, F. Story Musgrave, Kathryn C. Thornton and Manley L. Carter.

Wet Flow Test at Launch Complex 39B

NASA Image and Video Library

2017-12-20

About 450,000 gallons of water flowed at high speed from a holding tank through new and modified piping and valves, the flame trench, flame deflector nozzles and mobile launcher interface risers during a wet flow test at Launch Pad 39B at NASA's Kennedy Space Center in Florida. At peak flow, the water reached about 100 feet in the air above the pad surface. The test was a milestone to confirm and baseline the performance of the Ignition Overpressure/Sound Suppression system. During launch of NASA's Space Launch System rocket and Orion spacecraft, the high-speed water flow will help protect the vehicle from the extreme acoustic and temperature environment during ignition and liftoff.

STS-80 Columbia, OV 102, liftoff from KSC Launch Pad 39B

NASA Image and Video Library

1996-11-19

STS080-S-007 (19 Nov. 1996) --- One of the nearest remote camera stations to Launch Pad B captured this profile image of space shuttle Columbia's liftoff from the Kennedy Space Center's (KSC) Launch Complex 39 at 2:55:47 p.m. (EST), November 19, 1996. Onboard are astronauts Kenneth D. Cockrell, mission commander; Kent V. Rominger, pilot; along with Story Musgrave, Tamara E. Jernigan and Thomas D. Jones, all mission specialists. The two primary payloads for STS-80 stowed in Columbia?s cargo bay for later deployment and testing are the Wake Shield Facility (WSF-3) and the Orbiting and Retrievable Far and Extreme Ultraviolet Spectrometer (ORFEUS) with its associated Shuttle Pallet Satellite (SPAS).

2017 ASCAN Tour of KSC

NASA Image and Video Library

2018-05-02

The 2017 class of astronaut candidates are at United Launch Alliance's Space Launch Complex 41 at Cape Canaveral Air Force Station (CCAFS) in Florida for a familiarization tour. They also toured facilities at Kennedy Space Center, including the Neil Armstrong Operations and Checkout Building high bay; the Launch Control Center, Launch Complex 39B, the Vehicle Assembly Building, Boeing's Commercial Crew and Cargo Facility, and SpaceX's Launch Complex 39A. The candidates will spend about two years getting to know the space station systems and learning how to spacewalk, speak Russian, control the International Space Station's robotic arm and fly T-38s, before they're eligible to be assigned to a mission.

STS-86 Crew Photo outside hatch in LC-39A White Room

NASA Technical Reports Server (NTRS)

1997-01-01

STS-86 crew members pose for a group photograph outside the hatch to the crew cabin of the Space Shuttle Atlantis at Launch Pad 39A. Kneeling in front, from left, are Mission Specialists Vladimir Georgievich Titov of the Russian Space Agency, David A. Wolf and Wendy B. Lawrence. Standing, from left, are Pilot Michael J. Bloomfield, Mission Specialist Scott E. Parazynski, Commander James D. Wetherbee, and Mission Specialist Jean-Loup J.M. Chretien of the French Space Agency, CNES. STS-86 will be the seventh docking of the Space Shuttle with the Russian Space Station Mir. During the docking, Wolf will transfer to the orbiting Russian station and become a member of the Mir 24 crew, replacing U.S. astronaut C. Michael Foale, who has been on the Mir since the last docking mission, STS-84, in May. Launch of Mission STS-86 aboard the Space Shuttle Atlantis is targeted for Sept. 25.

10 CFR 9.39 - Search and duplication provided without charge.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Search and duplication provided without charge. 9.39... § 9.39 Search and duplication provided without charge. (a) The NRC will search for agency records... the news media. (b) The NRC will search for agency records requested under § 9.23(b) without charges...

10 CFR 9.39 - Search and duplication provided without charge.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Search and duplication provided without charge. 9.39... § 9.39 Search and duplication provided without charge. (a) The NRC will search for agency records... the news media. (b) The NRC will search for agency records requested under § 9.23(b) without charges...

10 CFR 9.39 - Search and duplication provided without charge.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Search and duplication provided without charge. 9.39... § 9.39 Search and duplication provided without charge. (a) The NRC will search for agency records... the news media. (b) The NRC will search for agency records requested under § 9.23(b) without charges...

10 CFR 9.39 - Search and duplication provided without charge.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Search and duplication provided without charge. 9.39... § 9.39 Search and duplication provided without charge. (a) The NRC will search for agency records... the news media. (b) The NRC will search for agency records requested under § 9.23(b) without charges...

HST Hot-Jupiter Transmission Spectral Survey: Clear Skies for Cool Saturn WASP-39b

NASA Astrophysics Data System (ADS)

Fischer, Patrick D.; Knutson, Heather A.; Sing, David K.; Henry, Gregory W.; Williamson, Michael W.; Fortney, Jonathan J.; Burrows, Adam S.; Kataria, Tiffany; Nikolov, Nikolay; Showman, Adam P.; Ballester, Gilda E.; Désert, Jean-Michel; Aigrain, Suzanne; Deming, Drake; Lecavelier des Etangs, Alain; Vidal-Madjar, Alfred

2016-08-01

We present the Hubble Space Telescope (HST) Space Telescope Imaging Spectrograph (STIS) optical transmission spectroscopy of the cool Saturn-mass exoplanet WASP-39b from 0.29-1.025 μm, along with complementary transit observations from Spitzer IRAC at 3.6 and 4.5 μm. The low density and large atmospheric pressure scale height of WASP-39b make it particularly amenable to atmospheric characterization using this technique. We detect a Rayleigh scattering slope as well as sodium and potassium absorption features; this is the first exoplanet in which both alkali features are clearly detected with the extended wings predicted by cloud-free atmosphere models. The full transmission spectrum is well matched by a clear H2-dominated atmosphere, or one containing a weak contribution from haze, in good agreement with the preliminary reduction of these data presented in Sing et al. WASP-39b is predicted to have a pressure-temperature profile comparable to that of HD 189733b and WASP-6b, making it one of the coolest transiting gas giants observed in our HST STIS survey. Despite this similarity, WASP-39b appears to be largely cloud-free, while the transmission spectra of HD 189733b and WASP-6b both indicate the presence of high altitude clouds or hazes. These observations further emphasize the surprising diversity of cloudy and cloud-free gas giant planets in short-period orbits and the corresponding challenges associated with developing predictive cloud models for these atmospheres.

76 FR 63177 - Airworthiness Directives; Airbus Model A300 B2-1C, A300 B2-203, A300 B2K-3C, A300-B4-103, A300 B4...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-12

... available in the AD docket shortly after receipt. List of Subjects in 14 CFR Part 39 Air transportation... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011... B4-2C Airplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT...

KSC-2014-2625

NASA Image and Video Library

2014-05-20

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, Mobile Launcher Platform-2, or MLP-2, is glimpsed across the water as it departs Launch Pad 39A atop a crawler-transporter. A pad on Cape Canaveral Air Force Station is in view in the background. The MLP is being moved to a nearby park site in Launch Complex 39. The historic launch pad was the site from which numerous Apollo and space shuttle missions began and is beginning a new mission as a commercial launch site. NASA signed a property agreement with Space Exploration Technologies Corp., or SpaceX, of Hawthorne, California, on April 14 for use and occupancy of the seaside complex along Florida's central east coast. It will serve as a platform for SpaceX to support their commercial launch activities. For more information on Launch Pad 39A, visit http://www.nasa.gov/centers/kennedy/pdf/167416main_LC39-08.pdf. For learn more about the crawler-transporter, visit http://www.nasa.gov/centers/kennedy/pdf/167402main_crawlertransporters07.pdf. Photo credit: NASA/Kim Shiflett

Saturn 1B space vehicle for ASTP moves from VAB to launch complex

NASA Image and Video Library

1975-03-24

S75-24007 (24 March 1975) --- The Saturn 1B space vehicle for the Apollo-Soyuz Test Project mission, with its launch umbilical tower, rides atop a huge crawler-transporter as it moves slowly away from the Vehicle Assembly Building on its 4.24-mile journey to Pad B, Launch Complex 39, at NASA's Kennedy Space Center. The ASTP vehicle is composed of a Saturn 1B (first) stage, a Saturn IVB (second) stage, and a payload consisting of a Command/Service Module and a Docking Module. The joint U.S.-USSR ASTP docking mission in Earth orbit is scheduled for July 1975.

Amphotericin B lipid complex in the treatment of severe paracoccidioidomycosis: a case series.

PubMed

Peçanha, Paulo Mendes; de Souza, Stella; Falqueto, Aloísio; Grão-Veloso, Tânia Regina; Lírio, Ludmila Ventura; Ferreira, Carlos Urbano Gonçalves; Santos, Aline Rocha; Costa, Hélbia Garcia; de Souza, Lúcia Renata Meirelles; Tuon, Felipe Francisco

2016-10-01

Amphotericin B deoxycholate is the main option for intravenous (i.v.) treatment of severe paracoccidioidomycosis (PCM). This is the first report of amphotericin B lipid complex (ABLC) in the treatment of PCM. Among 28 patients, cure was achieved in all patients (100%) using ABLC. Mean and median daily doses of ABLC were 3.39 mg/kg/day and 3.35 mg/kg/day, respectively. ABLC may be a choice in the treatment of severe forms of PCM or when i.v. options are required. Copyright © 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

27 CFR 21.39 - Formula No. 6-B.

Code of Federal Regulations, 2010 CFR

2010-04-01

... chemicals. (2) Miscellaneous uses: 812.Product development and pilot plant uses (own use only). ... and Authorized Uses § 21.39 Formula No. 6-B. (a) Formula. To every 100 gallons of alcohol add: One-half gallon of pyridine bases. (b) Authorized uses. (1) As a raw material: 523.Miscellaneous ethyl...

27 CFR 21.39 - Formula No. 6-B.

Code of Federal Regulations, 2011 CFR

2011-04-01

... chemicals. (2) Miscellaneous uses: 812.Product development and pilot plant uses (own use only). ... and Authorized Uses § 21.39 Formula No. 6-B. (a) Formula. To every 100 gallons of alcohol add: One-half gallon of pyridine bases. (b) Authorized uses. (1) As a raw material: 523.Miscellaneous ethyl...

Construction bidding cost of KSC's space shuttle facilities

NASA Technical Reports Server (NTRS)

Brown, Joseph Andrew

1977-01-01

The bidding cost of the major Space Transportation System facilities constructed under the responsibility of the John F. Kennedy Space Center (KSC) is described and listed. These facilities and Ground Support Equipment (GSE) are necessary for the receiving, assembly, testing, and checkout of the Space Shuttle for launch and landing missions at KSC. The Shuttle launch configuration consists of the Orbiter, the External Tank, and the Solid Rocket Boosters (SRB). The reusable Orbiter and SRB's is the major factor in the program that will result in lowering space travel costs. The new facilities are the Landing Facility; Orbiter Processing Facility; Orbiter Approach and Landing Test Facility (Dryden Test Center, California); Orbiter Mating Devices; Sound Suppression Water System; and Emergency Power System for LC-39. Also, a major factor was to use as much Apollo facilities and hardware as possible to reduce the facilities cost. The alterations to existing Apollo facilities are the VAB modifications; Mobile Launcher Platforms; Launch Complex 39 Pads A and B (which includes a new concept - the Rotary Service Structure), which was featured in ENR, 3 Feb. 1977, 'Hinged Space Truss will Support Shuttle Cargo Room'; Launch Control Center mods; External Tank and SRB Processing and Storage; Fluid Test Complex mods; O&C Spacelab mods; Shuttle mods for Parachute Facility; SRB Recovery and Disassembly Facility at Hangar 'AF'; and an interesting GSE item - the SRB Dewatering Nozzle Plug Sets (Remote Controlled Submarine System) used to inspect and acquire for reuse of SRB's.

Air-to-air view of STS-32 Columbia, OV-102, launch

NASA Image and Video Library

1990-01-09

STS-32 Columbia, Orbiter Vehicle (OV) 102, pierces a layer of low lying clouds as it makes its ascent to Earth orbit for a 10-day mission. In this air-to-air view, OV-102 rides atop the external tank (ET) with flames created by solid rocket boosters (SRBs) appearing directly underneath it and a long plume of exhaust smoke trailing behind it and extending to Kennedy Space Center (KSC) Launch Complex (LC) Pad 39A below. OV-102 left KSC LC Pad 39A at 7:34:59:98 am Eastern Standard Time (EST) some 24 hours after dubious weather at the return-to-landing site (RTLS) had cancelled a scheduled launch. The photo was taken by astronaut Michael L. Coats, acting chief of the Astronaut Office, from the Shuttle Training Aircraft (STA).

48 CFR 52.247-39 - F.o.b. Inland Point, Country of Importation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false F.o.b. Inland Point... Provisions and Clauses 52.247-39 F.o.b. Inland Point, Country of Importation. As prescribed in 47.303-11(c), insert the following clause in solicitations and contracts when the delivery term is f.o.b. inland point...

Interaction between transposable phages: cip locus of prophage D3112, responsible for inhibition of integration and transposition of the related phage B39 of Pseudomonas aeruginosa

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gerasimov, V.A.; Yanenko, A.S.; Akhverdyan, V.Z.

1986-04-01

Bacteriophage D3112 forms two types of PA01 (D3112) lysogens: those that partially, or completely, limit the growth of the related heteroimmune phage B39. DNA/DNA hybridization has shown that the lysogens of the first type always contain one copy of prophage D3112 (monolysogens), and the lysogens of the second type contain two or more copies of prophage D3112. Limitation of the growth of phage B39 on PA01 (D3112) lysogens is associated with the functioning of the locus of prophage D3112, designated as cip (control of interaction of phages). Using deletion derivatives of plasmid RP4::D3112, the cip locus was mapped at anmore » interval of 1.3-2.45 kb of the D3112 genome. The expression of the cip locus occurs only if the D3112 genome is at the prophage state. The function of the Cip prophage of D3112 exerts an influence on early stages of development of phage B39, decreasing the efficiency of the integration and transposition processes of phage B39.« less

Water Deluge Test at Launch Complex 39B

NASA Image and Video Library

2018-05-24

About 450,000 gallons of water flow at high speed from a holding tank through new and modified piping and valves, the flame trench, flame deflector nozzles and mobile launcher interface risers during a wet flow test on May 24, 2018, at Launch Pad 39B at NASA's Kennedy Space Center in Florida. At peak flow, the water reached about 100 feet in the air above the pad surface. The test was performed by Exploration Ground Systems to confirm the performance of the Ignition Overpressure/Sound Suppression system. During launch of NASA's Space Launch System rocket and Orion spacecraft, the high-speed water flow will help protect the vehicle from the extreme acoustic and temperature environment during ignition and liftoff.

27 CFR 21.151 - List of denaturants authorized for denatured spirits.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Denatured Rum (S.D.R.) Acetaldehyde S.D.A. 29. Acetone, U.S.P S.D.A. 23-A, 23-H. Acetaldol C.D.A. 18. Almond... alcohol S.D.A. 39, 39-A, 39-B, 40, 40-A, 40-B, 40-C. Camphor, U.S.P S.D.A. 27, 27-A, 38-B. Caustic soda.... Formaldehyde solution, U.S.P S.D.A. 22, 38-C, 38-D. Gasoline C.D.A. 18, 19; S.D.A. 28-A. Gasoline, unleaded C.D...

27 CFR 21.151 - List of denaturants authorized for denatured spirits.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Denatured Rum (S.D.R.) Acetaldehyde S.D.A. 29. Acetone, U.S.P S.D.A. 23-A, 23-H. Acetaldol C.D.A. 18. Almond... alcohol S.D.A. 39, 39-A, 39-B, 40, 40-A, 40-B, 40-C. Camphor, U.S.P S.D.A. 27, 27-A, 38-B. Caustic soda.... Formaldehyde solution, U.S.P S.D.A. 22, 38-C, 38-D. Gasoline C.D.A. 18, 19; S.D.A. 28-A. Gasoline, unleaded C.D...

HST HOT-JUPITER TRANSMISSION SPECTRAL SURVEY: CLEAR SKIES FOR COOL SATURN WASP-39b

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fischer, Patrick D.; Knutson, Heather A.; Sing, David K.

We present the Hubble Space Telescope (HST) Space Telescope Imaging Spectrograph (STIS) optical transmission spectroscopy of the cool Saturn-mass exoplanet WASP-39b from 0.29-1.025 μ m, along with complementary transit observations from Spitzer IRAC at 3.6 and 4.5 μ m. The low density and large atmospheric pressure scale height of WASP-39b make it particularly amenable to atmospheric characterization using this technique. We detect a Rayleigh scattering slope as well as sodium and potassium absorption features; this is the first exoplanet in which both alkali features are clearly detected with the extended wings predicted by cloud-free atmosphere models. The full transmission spectrummore » is well matched by a clear H{sub 2}-dominated atmosphere, or one containing a weak contribution from haze, in good agreement with the preliminary reduction of these data presented in Sing et al. WASP-39b is predicted to have a pressure-temperature profile comparable to that of HD 189733b and WASP-6b, making it one of the coolest transiting gas giants observed in our HST STIS survey. Despite this similarity, WASP-39b appears to be largely cloud-free, while the transmission spectra of HD 189733b and WASP-6b both indicate the presence of high altitude clouds or hazes. These observations further emphasize the surprising diversity of cloudy and cloud-free gas giant planets in short-period orbits and the corresponding challenges associated with developing predictive cloud models for these atmospheres.« less

78 FR 6359 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

... related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015.5. Id. Attachment B. The..., authorizing the new product; Attachment B--a redacted copy of the contract; Attachment C--proposed changes to... POSTAL REGULATORY COMMISSION [Docket No. MC2013-34 and CP2013-45; Order No. 1635] New Postal...

77 FR 60725 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-04

... related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015.5. Id. Attachment B. The..., authorizing the new product; Attachment B--a redacted copy of the contract; Attachment C--proposed changes to... POSTAL REGULATORY COMMISSION [Docket Nos. MC2012-54 and CP2012-66; Order No. 1486] New Postal...

76 FR 39254 - Airworthiness Directives; Schweizer Aircraft Corporation (Schweizer) Model 269A, A-1, B, C, C-1...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-06

... Airworthiness Directives; Schweizer Aircraft Corporation (Schweizer) Model 269A, A-1, B, C, C-1, and TH-55... reviewed Schweizer Service Bulletins No. B-295 for Model 269A, A-1, B, and C helicopters, and No. C1B-032... citation for Part 39 continues to read as follows: Authority: 49 U.S.C. 106(g), 40113, 44701. Sec. 39.13...

GENERAL VIEW OF VEHICLE ACCESS PLATFORM BNORTH, HB3, FACING NORTH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF VEHICLE ACCESS PLATFORM B-NORTH, HB-3, FACING NORTH - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

GENERAL VIEW OF VEHICLE ACCESS PLATFORM BNORTH, HB3, FACING NORTHEAST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF VEHICLE ACCESS PLATFORM B-NORTH, HB-3, FACING NORTHEAST - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity*

PubMed Central

van der Kant, Rik; Jonker, Caspar T. H.; Wijdeven, Ruud H.; Bakker, Jeroen; Janssen, Lennert; Klumperman, Judith; Neefjes, Jacques

2015-01-01

Trafficking of cargo through the endosomal system depends on endosomal fusion events mediated by SNARE proteins, Rab-GTPases, and multisubunit tethering complexes. The CORVET and HOPS tethering complexes, respectively, regulate early and late endosomal tethering and have been characterized in detail in yeast where their sequential membrane targeting and assembly is well understood. Mammalian CORVET and HOPS subunits significantly differ from their yeast homologues, and novel proteins with high homology to CORVET/HOPS subunits have evolved. However, an analysis of the molecular interactions between these subunits in mammals is lacking. Here, we provide a detailed analysis of interactions within the mammalian CORVET and HOPS as well as an additional endosomal-targeting complex (VIPAS39-VPS33B) that does not exist in yeast. We show that core interactions within CORVET and HOPS are largely conserved but that the membrane-targeting module in HOPS has significantly changed to accommodate binding to mammalian-specific RAB7 interacting lysosomal protein (RILP). Arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome-associated mutations in VPS33B selectively disrupt recruitment to late endosomes by RILP or binding to its partner VIPAS39. Within the shared core of CORVET/HOPS, we find that VPS11 acts as a molecular switch that binds either CORVET-specific TGFBRAP1 or HOPS-specific VPS39/RILP thereby allowing selective targeting of these tethering complexes to early or late endosomes to time fusion events in the endo/lysosomal pathway. PMID:26463206

“W-X-M” transformations in isomerization of B{sub 39}{sup −} borospherenes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gao, Ting-Ting; Chen, Qiang; Mu, Yue-Wen

2016-06-15

The Stone-Wales transformation plays an important role in the isomerization of fullerenes and graphenic systems. The continuous conversions between neighboring six- and seven-membered rings in the borospherene (all-boron fullerene) B{sub 40} had been discovered (Martínez-Guajardo et al. Sci. Rep. 5, 11287 (2015)). In the first axially chiral borospherenes C{sub 3} B{sub 39}{sup −} and C{sub 2} B{sub 39}{sup −}, we identify three active boron atoms which are located at the center of three alternative sites involving five boron atoms denoted as “W”, “X”, and “M”, respectively. The concerted movements of these active boron atoms and their close neighbors between neighboringmore » six- and seven-membered rings define the “W-X-M” transformation of borospherenes. Extensive first-principles molecular dynamics simulations and quadratic synchronous transit transition-state searches indicate that, via three transition states (TS1, TS2, and TS3) and two intermediate species (M1 and M2), the three-step “W-X-M” transformations convert the C{sub 3} B{sub 39}{sup −} global minimum into its C{sub 2} isomer at room temperature (300 K) and vice versa. The maximum barriers are only 3.89 kcal/mol from C{sub 3} to C{sub 2} B{sub 39}{sup −} and 2.1 kcal/mol from C{sub 2} to C{sub 3} B{sub 39}{sup −}, rendering dynamic fluxionalities to these borospherenes. Therefore, the “W-X-M” transformation plays an important role in the borospherenes and borospherene-based nanostructures.« less

KSC Launch Pad Flame Trench Environment Assessment

NASA Technical Reports Server (NTRS)

Calle, Luz Marina; Hintze, Paul E.; Parlier, Christopher R.; Curran, Jerome P.; Kolody, Mark R.; Sampson, Jeffrey W.

2010-01-01

This report summarizes conditions in the Launch Complex 39 (LC-39) flame trenches during a Space Shuttle Launch, as they have been measured to date. Instrumentation of the flame trench has been carried out by NASA and United Space Alliance for four Shuttle launches. Measurements in the flame trench are planned to continue for the duration of the Shuttle Program. The assessment of the launch environment is intended to provide guidance in selecting appropriate test methods for refractory materials used in the flame trench and to provide data used to improve models of the launch environment in the flame trench.

FILMING OF 'CONTACT' AT LC39 PRESS SITE SEEN FROM VAB ROOF

NASA Technical Reports Server (NTRS)

1997-01-01

The filming of scenes for the movie 'Contact' by Warner Bros.' cast and crew at Kennedy Space Center's Launch Complex 39 Press Site on January 29 is captured by cameras on the roof of the Vehicle Assembly Building. The screenplay for 'Contact' is based on the best-selling novel by the late astronomer Carl Sagan. The cast includes Jodie Foster, Matthew McConaughey, John Hurt, James Woods, Tom Skerritt, David Morse, William Fichtner, Rob Lowe and Angela Bassett. Described by Warner Bros. as a science fiction drama, 'Contact' will depict humankind's first encounter with evidence of extraterrestrial life.

FILMING OF 'CONTACT' AT LC39 PRESS SITE WITH VAB IN BACKGROUND

NASA Technical Reports Server (NTRS)

1997-01-01

With the Vehicle Assembly Building looming in the background, Warner Bros.' cast and crew are filming scenes for the movie 'Contact' at Kennedy Space Center's Launch Complex 39 Press Site on January 29. The screenplay for 'Contact' is based on the best- selling novel by the late astronomer Carl Sagan. The cast includes Jodie Foster, Matthew McConaughey, John Hurt, James Woods, Tom Skerritt, David Morse, William Fichtner, Rob Lowe and Angela Bassett. Described by Warner Bros. as a science fiction drama, 'Contact' will depict humankind's first encounter with evidence of extraterrestrial life.

DIRECTOR/PRODUCER ROBERT ZEMECKIS DURING FILMING OF 'CONTACT' AT LC39 PRESS SITE

NASA Technical Reports Server (NTRS)

1997-01-01

Robert Zemeckis, director/producer, and other Warner Bros. crew members oversee the filming of scenes for the movie 'Contact' at Kennedy Space Center's Launch Complex 39 Press Site on January 30. The screenplay for 'Contact' is based on the best-selling novel by the late astronomer Carl Sagan. The cast includes Jodie Foster, Matthew McConaughey, John Hurt, James Woods, Tom Skerritt, David Morse, William Fichtner, Rob Lowe and Angela Bassett. Described by Warner Bros. as a science fiction drama, 'Contact' will depict humankind's first encounter with evidence of extraterrestrial life.

FILMING OF 'CONTACT' AT LC39 PRESS SITE WITH VAB IN BACKGROUND

NASA Technical Reports Server (NTRS)

1997-01-01

With the Vehicle Assembly Building looming in the background, Warner Bros.' cast and crew are filming scenes for the movie 'Contact' at Kennedy Space Center's Launch Complex 39 Press Site on January 30. The screenplay for 'Contact' is based on the best- selling novel by the late astronomer Carl Sagan. The cast includes Jodie Foster, Matthew McConaughey, John Hurt, James Woods, Tom Skerritt, David Morse, William Fichtner, Rob Lowe and Angela Bassett. Described by Warner Bros. as a science fiction drama, 'Contact' will depict humankind's first encounter with evidence of extraterrestrial life.

STS-112 Atlantis Launch from LC-39B

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. - A distant view creates a frame of leaves around the launch of Space Shuttle Atlantis on mission STS-112. Liftoff occurred on time at 3:46 p.m. EDT. Along with a crew of six, Atlantis carries the S1 Integrated Truss Structure and the Crew and Equipment Translation Aid (CETA) Cart A. The CETA is the first of two human-powered carts that will ride along the ISS railway, providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss and CETA Cart A.

STS-112 Atlantis Launch from LC-39B

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- The brilliance of the launch of Space Shuttle Atlantis is reflected in nearby waters. Liftoff of the Shuttle on mission STS-112 occurred on time at 3:46 p.m. EDT. Along with a crew of six, Atlantis carries the S1 Integrated Truss Structure and the Crew and Equipment Translation Aid (CETA) Cart A. The CETA is the first of two human-powered carts that will ride along the ISS railway, providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss.

STS-112 Atlantis Launch from LC-39B

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. - The afternoon sun casts a shadow on Space Shuttle Atlantis as it launches on its journey to the International Space Station. Liftoff occurred on time at 3:46 p.m. EDT. Along with a crew of six, Atlantis carries the S1 Integrated Truss Structure and the Crew and Equipment Translation Aid (CETA) Cart A. The CETA is the first of two human-powered carts that will ride along the ISS railway, providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss and CETA cart.

Down-regulation of CD73 on B cells of patients with viremic HIV correlates with B cell activation and disease progression.

PubMed

Kim, Eun-Seong; Ackermann, Christin; Tóth, Ilona; Dierks, Patrick; Eberhard, Johanna M; Wroblewski, Raluca; Scherg, Felix; Geyer, Matthias; Schmidt, Reinhold E; Beisel, Claudia; Bockhorn, Maximilian; Haag, Friedrich; van Lunzen, Jan; Schulze Zur Wiesch, Julian

2017-05-01

Recently, alterations of the T cell expression of the ectonucleotidases, CD39 and CD73, during HIV infection have been described. Here, peripheral ( n = 70) and lymph nodal B cells ( n = 10) of patients with HIV at different stages of disease as well as uninfected individuals were analyzed via multicolor flow cytometry with regard to expression of CD39 and CD73 and differentiation, proliferation, and exhaustion status. Patients with chronic, untreated HIV showed a significantly decreased frequency of CD73-expressing B cells ( P < 0.001) compared with healthy controls. Decreased frequencies of CD39 + CD73 + B cells in patients with HIV correlated with low CD4 + counts ( P < 0.0256) as well as increased proliferation and exhaustion status as determined by Ki-67 and programmed death-1 expression. Down-regulation of CD73 was observed in naive and memory B cells as determined by CD27 and CD21. Neither HIV elite controller patients nor antiretroviral therapy-treated patients had significantly lower CD39 and CD73 expression on B cells compared with healthy controls. Of importance, low CD73 + expression on B cells was associated with modulated in vitro B cell function. Further in vivo studies are warranted to evaluate the in vivo role of phenotypic loss of CD73 in B cell dysregulation in HIV. © Society for Leukocyte Biology.

Applied Computational Fluid Dynamics in Support of Aircraft/Store Compatibility and Weapons Integration -2007 Edition

DTIC Science & Technology

2007-06-01

CFD in the AFSEO The SBD, designated GBU - 39 /B, contains a 250 production environment include the requirement for rapid pound warhead, measures 6 feet...Take Off (RATO) Separation." ITEA Conference, Apr 2006. Figure 3. B-52/MOP Figure 1. GBU - 39 /B small diameter bomb computational model Figure 4. MOP

36 CFR 1193.39 - Prohibited reduction of accessibility, usability, and compatibility.

Code of Federal Regulations, 2010 CFR

2010-07-01

... accessibility, usability, and compatibility. 1193.39 Section 1193.39 Parks, Forests, and Public Property... Requirements for Accessibility and Usability § 1193.39 Prohibited reduction of accessibility, usability, and... accessibility, usability, or compatibility of telecommunications equipment or customer premises equipment. (b...

36 CFR 1193.39 - Prohibited reduction of accessibility, usability, and compatibility.

Code of Federal Regulations, 2011 CFR

2011-07-01

... accessibility, usability, and compatibility. 1193.39 Section 1193.39 Parks, Forests, and Public Property... Requirements for Accessibility and Usability § 1193.39 Prohibited reduction of accessibility, usability, and... accessibility, usability, or compatibility of telecommunications equipment or customer premises equipment. (b...

36 CFR 1193.39 - Prohibited reduction of accessibility, usability, and compatibility.

Code of Federal Regulations, 2014 CFR

2014-07-01

... accessibility, usability, and compatibility. 1193.39 Section 1193.39 Parks, Forests, and Public Property... Requirements for Accessibility and Usability § 1193.39 Prohibited reduction of accessibility, usability, and... accessibility, usability, or compatibility of telecommunications equipment or customer premises equipment. (b...

36 CFR 1193.39 - Prohibited reduction of accessibility, usability, and compatibility.

Code of Federal Regulations, 2012 CFR

2012-07-01

... accessibility, usability, and compatibility. 1193.39 Section 1193.39 Parks, Forests, and Public Property... Requirements for Accessibility and Usability § 1193.39 Prohibited reduction of accessibility, usability, and... accessibility, usability, or compatibility of telecommunications equipment or customer premises equipment. (b...

39 CFR 3010.13 - Proceedings for Type 1-A and Type 1-B rate adjustment filings.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Proceedings for Type 1-A and Type 1-B rate... (Type 1-A and 1-B Rate Adjustments) § 3010.13 Proceedings for Type 1-A and Type 1-B rate adjustment... include: (1) The general nature of the proceeding; (2) A reference to legal authority to which the...

Fluorescence 'turn-on' sensor for F- derived from vitamin B6 cofactor.

PubMed

Sharma, Darshna; Sahoo, Suban K; Chaudhary, Soma; Bera, Rati Kanta; Callan, John F

2013-07-07

A novel vitamin B6 Schiff base analog (L) was synthesized by combining vitamin B6 cofactor pyridoxal with 2-aminophenol. Receptor L displays a color change detectable by the naked-eye from yellow to red in the presence of fluoride and acetate due to the formation of hydrogen bonding host-guest complexes in 1 : 1 stoichiometry. Importantly, receptor L showed fluoride-selective 'turn-on' fluorescent response with a detection limit (3σ) of 7.39 × 10(-8) M.

Fourier-transform spectroscopy and deperturbation analysis of the spin-orbit coupled A{sup 1}Σ{sup +} and b{sup 3}Π states of KRb

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alps, K.; Kruzins, A.; Tamanis, M.

Fourier-transform A{sup 1}Σ{sup +} − b{sup 3}Π → X{sup 1}Σ{sup +} laser-induced fluorescence spectra were recorded for the natural mixture of {sup 39,41}K{sup 85,87}Rb isotopologues produced in a heatpipe oven. Overall 4200 rovibronic term values of the spin-orbit coupled A{sup 1}Σ{sup +} and b{sup 3}Π states were determined with an uncertainty of about 0.01 cm{sup −1} in the energy range [10 850, 14 200] cm{sup −1} covering rotational quantum numbers J′ ∈ [3, 280]. Direct deperturbation analysis of the A ∼ b complex performed within the framework of the A{sup 1}Σ{sup +} ∼ b{sup 3}Π{sub Ω=0,1,2} coupled-channel approach reproduced experimental data withmore » a standard deviation of 0.004 cm{sup −1}. Initial parameters of the internuclear potentials and spin-orbit coupling functions along with the relevant transition dipole moments were obtained by performing the quasi-relativistic electronic structure calculations. The mass-invariant molecular parameters obtained from the fit were used to predict energy and radiative properties of the A ∼ b complex for low J levels of {sup 39}K{sup 85}Rb as well as for {sup 41}K{sup 87}Rb isotopologues, allowing us to identify the most reasonable candidates for the stimulated Raman transitions between the initial uppermost vibrational levels of the a{sup 3}Σ{sup +} and X{sup 1}Σ{sup +} states, the intermediate levels of the A ∼ b complex, and the lowest absolute ground X{sup 1}Σ{sup +}(v = 0, J = 0) state.« less

N-acetylglucosamine-Mediated Expression of nagA and nagB in Streptococcus pneumoniae.

PubMed

Afzal, Muhammad; Shafeeq, Sulman; Manzoor, Irfan; Henriques-Normark, Birgitta; Kuipers, Oscar P

2016-01-01

In this study, we have explored the transcriptomic response of Streptococcus pneumoniae D39 to N-acetylglucosamine (NAG). Transcriptome comparison of S. pneumoniae D39 wild-type grown in chemically defined medium (CDM) in the presence of 0.5% NAG to that grown in the presence of 0.5% glucose revealed elevated expression of many genes/operons, including nagA, nagB, manLMN , and nanP . We have further confirmed the NAG-dependent expression of nagA, nagB, manLMN , and nanP by β-galactosidase assays. nagA, nagB and glmS are putatively regulated by a transcriptional regulator NagR. We predicted the operator site of NagR ( dre site) in P nagA , P nagB , and P glmS , which was further confirmed by mutating the predicted dre site in the respective promoters ( nagA, nagB , and glmS ). Growth comparison of Δ nagA , Δ nagB , and Δ glmS with the D39 wild-type demonstrates that nagA and nagB are essential for S. pneumoniae D39 to grow in the presence of NAG as a sole carbon source. Furthermore, deletion of ccpA shows that CcpA has no effect on the expression of nagA, nagB , and glmS in the presence of NAG in S . pneumoniae .

N-acetylglucosamine-Mediated Expression of nagA and nagB in Streptococcus pneumoniae

PubMed Central

Afzal, Muhammad; Shafeeq, Sulman; Manzoor, Irfan; Henriques-Normark, Birgitta; Kuipers, Oscar P.

2016-01-01

In this study, we have explored the transcriptomic response of Streptococcus pneumoniae D39 to N-acetylglucosamine (NAG). Transcriptome comparison of S. pneumoniae D39 wild-type grown in chemically defined medium (CDM) in the presence of 0.5% NAG to that grown in the presence of 0.5% glucose revealed elevated expression of many genes/operons, including nagA, nagB, manLMN, and nanP. We have further confirmed the NAG-dependent expression of nagA, nagB, manLMN, and nanP by β-galactosidase assays. nagA, nagB and glmS are putatively regulated by a transcriptional regulator NagR. We predicted the operator site of NagR (dre site) in PnagA, PnagB, and PglmS, which was further confirmed by mutating the predicted dre site in the respective promoters (nagA, nagB, and glmS). Growth comparison of ΔnagA, ΔnagB, and ΔglmS with the D39 wild-type demonstrates that nagA and nagB are essential for S. pneumoniae D39 to grow in the presence of NAG as a sole carbon source. Furthermore, deletion of ccpA shows that CcpA has no effect on the expression of nagA, nagB, and glmS in the presence of NAG in S. pneumoniae. PMID:27900287

STS-95 Space Shuttle Discovery rollout to Launch Pad 39B

NASA Technical Reports Server (NTRS)

1998-01-01

As daylight creeps over the horizon, STS-95 Space Shuttle Discovery, on the Mobile Launch Platform, arrives at Launch Complex Pad 39B after a 4.2-mile trip taking approximately 6 hours. At the left is the 'white room,' attached to the orbiter access arm. The white room is an environmental chamber that mates with the orbiter and holds six persons. At the launch pad, the orbiter, external tank and solid rocket boosters will undergo final preparations for the launch, scheduled to lift off Oct. 29. The mission includes research payloads such as the Spartan solar- observing deployable spacecraft, the Hubble Space Telescope Orbital Systems Test Platform, the International Extreme Ultraviolet Hitchhiker, as well as the SPACEHAB single module with experiments on space flight and the aging process.

Development of a Failure Theory for Concrete [Summary

DOT National Transportation Integrated Search

2012-01-01

Concrete has been in use for over 2,000 years, yet the behavior of this common, but complex, substance is not fully understood. This gap affects standard compressive strength testing (ASTM C 39), which does not account for structural effects caused b...

2017 ASCAN Tour of KSC

NASA Image and Video Library

2018-05-01

The 2017 class of astronaut candidates tour Boeing's Commercial Crew and Cargo Facility at NASA's Kennedy Space Center in Florida on May 1. They are at the center for a familiarization tour of facilities, including the Neil Armstrong Operations and Checkout Building high bay; the Launch Control Center, Launch Complex 39B, and the Vehicle Assembly Building. They also toured United Launch Alliance's Space Launch Complex 41 at Cape Canaveral Air Force Station, and SpaceX's Launch Complex 39A at Kennedy. The candidates will spend about two years getting to know the space station systems and learning how to spacewalk, speak Russian, control the International Space Station's robotic arm and fly T-38s, before they're eligible to be assigned to a mission.

2017 ASCAN Tour of KSC

NASA Image and Video Library

2018-05-01

The 2017 class of astronaut candidates arrive at Boeing's Commercial Crew and Cargo Facility at NASA's Kennedy Space Center in Florida on May 1. They are at the center for a familiarization tour of facilities, including the Neil Armstrong Operations and Checkout Building high bay; the Launch Control Center, Launch Complex 39B, and the Vehicle Assembly Building. They also toured United Launch Alliance's Space Launch Complex 41 at Cape Canaveral Air Force Station, and SpaceX's Launch Complex 39A at Kennedy. The candidates will spend about two years getting to know the space station systems and learning how to spacewalk, speak Russian, control the International Space Station's robotic arm and fly T-38s, before they're eligible to be assigned to a mission.

78 FR 62597 - 36(b)(1) Arms Sales Notification

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-22

... Block II missiles, 1000 GBU-39/B Small Diameter Bomb (SDB) with BRU-61 carriage systems, 40 CATM-84H... missiles, 1000 GBU-39/B Small Diameter Bombs (SDB), 40 CATM-84H Captive Air Training Missiles (CATM), 20... Small Diameter Bomb (SDB) I weapon is a 250-lb class, all-up round (AUR) that provides greater than 50nm...

39 CFR 320.8 - Suspension for international remailing.

Code of Federal Regulations, 2014 CFR

2014-07-01

... international remailing applies to the carriage by Carrier B and by Carrier C. Example (2). The bills addressed... of 39 U.S.C. 601(a)(1) through (6) and § 310.2(b)(1) through (6) of this chapter is suspended on all... are carried by Carrier B to New York where they are delivered to Carrier C for carriage to Europe...

39 CFR 320.8 - Suspension for international remailing.

Code of Federal Regulations, 2010 CFR

2010-07-01

... international remailing applies to the carriage by Carrier B and by Carrier C. Example (2). The bills addressed... of 39 U.S.C. 601(a)(1) through (6) and § 310.2(b)(1) through (6) of this chapter is suspended on all... are carried by Carrier B to New York where they are delivered to Carrier C for carriage to Europe...

39 CFR 320.8 - Suspension for international remailing.

Code of Federal Regulations, 2013 CFR

2013-07-01

... international remailing applies to the carriage by Carrier B and by Carrier C. Example (2). The bills addressed... of 39 U.S.C. 601(a)(1) through (6) and § 310.2(b)(1) through (6) of this chapter is suspended on all... are carried by Carrier B to New York where they are delivered to Carrier C for carriage to Europe...

39 CFR 320.8 - Suspension for international remailing.

Code of Federal Regulations, 2012 CFR

2012-07-01

... international remailing applies to the carriage by Carrier B and by Carrier C. Example (2). The bills addressed... of 39 U.S.C. 601(a)(1) through (6) and § 310.2(b)(1) through (6) of this chapter is suspended on all... are carried by Carrier B to New York where they are delivered to Carrier C for carriage to Europe...

39 CFR 320.8 - Suspension for international remailing.

Code of Federal Regulations, 2011 CFR

2011-07-01

... international remailing applies to the carriage by Carrier B and by Carrier C. Example (2). The bills addressed... of 39 U.S.C. 601(a)(1) through (6) and § 310.2(b)(1) through (6) of this chapter is suspended on all... are carried by Carrier B to New York where they are delivered to Carrier C for carriage to Europe...

38 CFR 39.9 - Hearings.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Hearings. 39.9 Section 39... General Provisions § 39.9 Hearings. (a) No application for a grant under this part shall be disapproved until the applicant has been afforded an opportunity for a hearing. (b) Whenever a hearing is requested...

10 CFR 39.67 - Radiation surveys.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Radiation surveys. 39.67 Section 39.67 Energy NUCLEAR... Requirements § 39.67 Radiation surveys. (a) The licensee shall make radiation surveys, including but not limited to the surveys required under paragraphs (b) through (e) of this section, of each area where...

10 CFR 39.67 - Radiation surveys.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Radiation surveys. 39.67 Section 39.67 Energy NUCLEAR... Requirements § 39.67 Radiation surveys. (a) The licensee shall make radiation surveys, including but not limited to the surveys required under paragraphs (b) through (e) of this section, of each area where...

10 CFR 39.67 - Radiation surveys.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Radiation surveys. 39.67 Section 39.67 Energy NUCLEAR... Requirements § 39.67 Radiation surveys. (a) The licensee shall make radiation surveys, including but not limited to the surveys required under paragraphs (b) through (e) of this section, of each area where...

10 CFR 39.67 - Radiation surveys.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Radiation surveys. 39.67 Section 39.67 Energy NUCLEAR... Requirements § 39.67 Radiation surveys. (a) The licensee shall make radiation surveys, including but not limited to the surveys required under paragraphs (b) through (e) of this section, of each area where...

10 CFR 39.67 - Radiation surveys.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Radiation surveys. 39.67 Section 39.67 Energy NUCLEAR... Requirements § 39.67 Radiation surveys. (a) The licensee shall make radiation surveys, including but not limited to the surveys required under paragraphs (b) through (e) of this section, of each area where...

36 CFR § 1193.39 - Prohibited reduction of accessibility, usability, and compatibility.

Code of Federal Regulations, 2013 CFR

2013-07-01

... accessibility, usability, and compatibility. § 1193.39 Section § 1193.39 Parks, Forests, and Public Property... Requirements for Accessibility and Usability § 1193.39 Prohibited reduction of accessibility, usability, and... accessibility, usability, or compatibility of telecommunications equipment or customer premises equipment. (b...

14 CFR 151.39 - Project eligibility.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Project eligibility. 151.39 Section 151.39... FEDERAL AID TO AIRPORTS Rules and Procedures for Airport Development Projects § 151.39 Project eligibility. (a) A project for construction or land acquisition may not be approved under subparts B and C unless...

14 CFR 151.39 - Project eligibility.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Project eligibility. 151.39 Section 151.39... FEDERAL AID TO AIRPORTS Rules and Procedures for Airport Development Projects § 151.39 Project eligibility. (a) A project for construction or land acquisition may not be approved under subparts B and C unless...

14 CFR 151.39 - Project eligibility.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Project eligibility. 151.39 Section 151.39... FEDERAL AID TO AIRPORTS Rules and Procedures for Airport Development Projects § 151.39 Project eligibility. (a) A project for construction or land acquisition may not be approved under subparts B and C unless...

STS-81 CREW DURING SAFETY EQUIPMENT DEMONSTRATION AT LC 39B DURING TCDT

NASA Technical Reports Server (NTRS)

1996-01-01

The STS-81 crew gets a description of safety equipment and emergency egress routes on Launch Pad 39B during Terminal Countdown Demonstration Test (TCDT) exercises for that mission. They are (from left): Mission Specialists Marsha S. Ivins, J.M. 'Jerry' Linenger and Peter J. K. 'Jeff' Wisoff; Mission Commander Michael A. Baker; Mission Specialist John M. Grunsfeld; and Pilot Brent W. Jett, Jr. STS-81 is the fifth Shuttle-Mir docking mission and will feature the transfer of Linenger to Mir to replace astronaut John Blaha, who has been on the orbital laboratory since Sept. 19 after arrival there during the STS-79 mission. During STS-81, Shuttle and Mir crews will conduct risk mitigation, human life science, microgravity and materials processing experiments that will provide data for the design, development and operation of the International Space Station. The primary payload is the SPACEHAB-DM double module will provide space for more than 2,000 pounds of hardware, food and water that will be transferred into the Russian space station during five days of docking operations during the 10-day mission. The SPACEHAB will also be used to return experiment samples from the Mir to Earth for analysis and for microgravity experiments during the mission.

STS-55 Columbia, Orbiter Vehicle (OV) 102, SSME abort at KSC LC Pad 39A

NASA Image and Video Library

1993-03-22

S93-31601 (March 1993) --- The second Space Shuttle launch attempt of 1993 comes to an abrupt halt when one of the three main engines on the orbiter Columbia shuts down at T -3 seconds, resulting in an on-the-pad abort of Mission STS-55. This was the first time in the post-Challenger era that a main engine shutdown has halted a Shuttle launch countdown, and only the third time in the history of the program. In 1984, STS-41D was scrubbed at T -4 seconds when the orbiter General Purpose Computer detected an anomaly in a main engine, and in 1985, STS-51F was halted at T -3 seconds due to a main engine malfunction that caused shutdown of all three engines. Columbia had been scheduled to lift off from Launch Pad 39B is the Space Shuttle Discovery, undergoing preparations for lift off on Mission STS-56.

75 FR 38007 - Airworthiness Directives; The Boeing Company Model 747-100, 747-100B, 747-100B SUD, 747-200B, 747...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-01

... the environmental control system (ECS). This AD results from reports of duct assemblies in the ECS... assemblies in the ECS wrapped with BMS 8-39 polyurethane foam insulation, a material of which the fire... igniting the BMS 8-39 polyurethane foam insulation on the duct assemblies of the ECS, which could propagate...

The RNA helicase DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation.

PubMed

Nakata, Daisuke; Nakao, Shoichi; Nakayama, Kazuhide; Araki, Shinsuke; Nakayama, Yusuke; Aparicio, Samuel; Hara, Takahito; Nakanishi, Atsushi

2017-01-29

Mounting evidence suggests that constitutively active androgen receptor (AR) splice variants, typified by AR-V7, are associated with poor prognosis and resistance to androgen deprivation therapy in prostate cancer patients. However, mechanisms governing the generation of AR splice variants are not fully understood. In this study, we aimed to investigate the dynamics of AR splice variant generation using the JDCaP prostate cancer model that expresses AR splice variants under androgen depletion. Microarray analysis of JDCaP xenografts before and after expression of AR splice variants suggested that dysregulation of RNA processing pathways is likely involved in AR splice variant generation. To explore factors contributing to generation of AR-V7 mRNA, we conducted a focused RNA interference screen in AR-V7-positive JDCaP-hr cells using an shRNA library targeting spliceosome-related genes. This screen identified DDX39B as a regulator of AR-V7 mRNA expression. Simultaneous knockdown of DDX39B and its paralog DDX39A drastically and selectively downregulated AR-V7 mRNA expression in multiple AR-V7-positive prostate cancer cell lines. DDX39B was upregulated in relapsed JDCaP xenografts expressing AR splice variants, suggesting its role in expression of AR splice variants. Taken together, our findings offer insight into the mechanisms of AR splice variant generation and identify DDX39 as a potential drug target for the treatment of AR splice variant-positive prostate cancer. Copyright © 2016 Elsevier Inc. All rights reserved.

STS-28 Columbia, OV-102, crewmembers leave KSC O&C Bldg en route to LC Pad 39

NASA Image and Video Library

1989-08-08

STS028-S-001 (8 Aug 1989) --- The five astronaut crewmembers for STS-28 leave the operations and checkout building to board a transfer van en route to Launch Complex 39 for a date with Columbia. Front to back are Brewster H. Shaw Jr., Richard N. Richards, David C. Leestma, James C. Adamson and Mark N. Brown. At the rear of the line are Astronaut Michael L. Coats, acting chief of the astronaut office; and Donald R. Puddy, director of flight crew operations at JSC. Coats later flew a NASA Shuttle training aircraft for pre-launch and launch monitoring activities.

MORIARTY, ZEMECKIS, BURGESS AND OTHERS DURING FILMING OF 'CONTACT' AT LC39 PRESS SITE

NASA Technical Reports Server (NTRS)

1997-01-01

From left, Bruce Moriarty, first assistant director; Robert Zemeckis, director/producer; Don Burgess, director of photography; and other Warner Bros. crew members oversee the filming of scenes for the movie 'Contact' at Kennedy Space Center's Launch Complex 39 Press Site on January 29. The screenplay for 'Contact' is based on the best-selling novel by the late astronomer Carl Sagan. The cast includes Jodie Foster, Matthew McConaughey, John Hurt, James Woods, Tom Skerritt, David Morse, William Fichtner, Rob Lowe and Angela Bassett. Described by Warner Bros. as a science fiction drama, 'Contact' will depict humankind's first encounter with evidence of extraterrestrial life.

Stuttgart, Germany. Revised Uniform Summary of Surface Weather Observations (RUSSWO)

DTIC Science & Technology

1988-07-01

4rREVISED UNIFORM SUMMARY OF SURFACE WEATHER OBSERVATIONS STUTTGART GERMANY MSC # 107380 N 48 41 K 009 13 ELEV 1300 FT EDOC PARTS A - F HOURS SUMMARIZED 0000...1 .. L. b I.E 725O0 14.2 24.A 26.4 32.3 32.1 33.6 34.2 36.7 37.7 9.2 39.c 39.5 39.7 𔄃.e 40. 1 I. . GE 6’ UC 1 14.4 25.3 27.0 30.6 32.8 34. 2 34*. 37.4...28.9 30.1 33.8 35.8 36.7 37.3 39.1 39.6 40.0 40.2 60.5 60.6 60.7 41.1 1.9 6E 8- uC l7.9 3L. b 31 .9 35.838 V.. 39. 139 . 7- 6’.6 - 42. 1-62. 7 42.9 4

Payload/GSE/data system interface: Users guide for the VPF (Vertical Processing Facility)

NASA Technical Reports Server (NTRS)

1993-01-01

Payload/GSE/data system interface users guide for the Vertical Processing Facility is presented. The purpose of the document is three fold. First, the simulated Payload and Ground Support Equipment (GSE) Data System Interface, which is also known as the payload T-0 (T-Zero) System is described. This simulated system is located with the Cargo Integration Test Equipment (CITE) in the Vertical Processing Facility (VPF) that is located in the KSC Industrial Area. The actual Payload T-0 System consists of the Orbiter, Mobile Launch Platforms (MLPs), and Launch Complex (LC) 39A and B. This is referred to as the Pad Payload T-0 System (Refer to KSC-DL-116 for Pad Payload T-0 System description). Secondly, information is provided to the payload customer of differences between this simulated system and the actual system. Thirdly, a reference guide of the VPF Payload T-0 System for both KSC and payload customer personnel is provided.

Urban Joint Fire Support: Air Force Fixed-Wing and Army Field Artillery Precision Munitions Capabilities for Urban Operations

DTIC Science & Technology

2007-06-15

of 2006, the GBU - 39 /B Small Diameter Bomb (SDB) was first employed by Air Force aircraft (Weisgerber 2006). This newly developed munition was...Vertical, Limited horizontal 500# Impact, Delay ≤ 3m GBU-38 JDAM GPS/INS Vertical, Horizontal 500# Proximity, Impact, Delay ~10m GBU - 39 /B...between 5 to 15 nautical miles, though LGB maximum employment range may be further limited by the need to acquire and lase the target. The GBU - 39 offers

T Cell Allorecognition via Molecular Mimicry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Macdonald, Whitney A.; Chen, Zhenjun; Gras, Stephanie

T cells often alloreact with foreign human leukocyte antigens (HLA). Here we showed the LC13 T cell receptor (TCR), selected for recognition on self-HLA-B*0801 bound to a viral peptide, alloreacts with B44 allotypes (HLA-B*4402 and HLA-B*4405) bound to two different allopeptides. Despite extensive polymorphism between HLA-B*0801, HLA-B*4402, and HLA-B*4405 and the disparate sequences of the viral and allopeptides, the LC13 TCR engaged these peptide-HLA (pHLA) complexes identically, accommodating mimicry of the viral peptide by the allopeptide. The viral and allopeptides adopted similar conformations only after TCR ligation, revealing an induced-fit mechanism of molecular mimicry. The LC13 T cells did notmore » alloreact against HLA-B*4403, and the single residue polymorphism between HLA-B*4402 and HLA-B*4403 affected the plasticity of the allopeptide, revealing that molecular mimicry was associated with TCR specificity. Accordingly, molecular mimicry that is HLA and peptide dependent is a mechanism for human T cell alloreactivity between disparate cognate and allogeneic pHLA complexes.« less

10 CFR 39.55 - Tritium neutron generator target sources.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Tritium neutron generator target sources. 39.55 Section 39... Equipment § 39.55 Tritium neutron generator target sources. (a) Use of a tritium neutron generator target....77. (b) Use of a tritium neutron generator target source, containing quantities exceeding 1,110 GBg...

10 CFR 39.55 - Tritium neutron generator target sources.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Tritium neutron generator target sources. 39.55 Section 39... Equipment § 39.55 Tritium neutron generator target sources. (a) Use of a tritium neutron generator target....77. (b) Use of a tritium neutron generator target source, containing quantities exceeding 1,110 GBg...

45 CFR 233.39 - Age.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 45 Public Welfare 2 2014-10-01 2012-10-01 true Age. 233.39 Section 233.39 Public Welfare... FINANCIAL ASSISTANCE PROGRAMS § 233.39 Age. (a) Condition for plan approval. A State plan under title I or XVI of the Social Security Act may not impose any age requirement of more than 65 years. (b) Federal...

45 CFR 233.39 - Age.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 2 2011-10-01 2011-10-01 false Age. 233.39 Section 233.39 Public Welfare... FINANCIAL ASSISTANCE PROGRAMS § 233.39 Age. (a) Condition for plan approval. A State plan under title I or XVI of the Social Security Act may not impose any age requirement of more than 65 years. (b) Federal...

45 CFR 233.39 - Age.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 2 2013-10-01 2012-10-01 true Age. 233.39 Section 233.39 Public Welfare... FINANCIAL ASSISTANCE PROGRAMS § 233.39 Age. (a) Condition for plan approval. A State plan under title I or XVI of the Social Security Act may not impose any age requirement of more than 65 years. (b) Federal...

45 CFR 233.39 - Age.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 2 2012-10-01 2012-10-01 false Age. 233.39 Section 233.39 Public Welfare... FINANCIAL ASSISTANCE PROGRAMS § 233.39 Age. (a) Condition for plan approval. A State plan under title I or XVI of the Social Security Act may not impose any age requirement of more than 65 years. (b) Federal...

10 CFR 39.55 - Tritium neutron generator target sources.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Tritium neutron generator target sources. 39.55 Section 39... Equipment § 39.55 Tritium neutron generator target sources. (a) Use of a tritium neutron generator target....77. (b) Use of a tritium neutron generator target source, containing quantities exceeding 1,110 GBg...

10 CFR 39.55 - Tritium neutron generator target sources.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 1 2013-01-01 2013-01-01 false Tritium neutron generator target sources. 39.55 Section 39... Equipment § 39.55 Tritium neutron generator target sources. (a) Use of a tritium neutron generator target....77. (b) Use of a tritium neutron generator target source, containing quantities exceeding 1,110 GBg...

10 CFR 39.55 - Tritium neutron generator target sources.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 1 2012-01-01 2012-01-01 false Tritium neutron generator target sources. 39.55 Section 39... Equipment § 39.55 Tritium neutron generator target sources. (a) Use of a tritium neutron generator target....77. (b) Use of a tritium neutron generator target source, containing quantities exceeding 1,110 GBg...

A New Lightning Instrumentation System for Pad 39B at the Kennedy Space Center Florida

NASA Technical Reports Server (NTRS)

Mata, C. T.; Rakov, V. A.

2011-01-01

This viewgraph presentation describes a new lightning instrumentation system for pad 39B at Kennedy Space Center Florida. The contents include: 1) Background; 2) Instrumentation; 3) Meteorological Instrumentation; and 4) Lessons learned. A presentation of the data acquired at Camp Blanding is also shown.

Astronaut Jean-Francois Clervoy in white room on launch pad 39B

NASA Technical Reports Server (NTRS)

1994-01-01

In the white room at Launch Pad 39B, STS-66 mission specialist Jean-Francois Clervoy is assisted with his partial pressure launch/entry suit by close-out crew members Travis Thompson and Danny Wyatt (background) before entering the Space Shuttle Atlantis for its November 3 launch.

77 FR 304 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-04

... POSTAL REGULATORY COMMISSION [Docket Nos. MC2012-3 and CP2012-7; Order No. 1072] New Postal Product AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a... proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015.5. Id. Attachment B. The instant contract...

Identification of proteomic signatures associated with lung cancer and COPD.

PubMed

Pastor, M D; Nogal, A; Molina-Pinelo, S; Meléndez, R; Salinas, A; González De la Peña, M; Martín-Juan, J; Corral, J; García-Carbonero, R; Carnero, A; Paz-Ares, L

2013-08-26

Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) commonly coexist in smokers, and the presence of COPD increases the risk of developing LC. The aim of this study was to identify distinct proteomic profiles able to discriminate these two pathological entities. Protein content was assessed in the bronchoalveolar lavage (BAL) of 60 patients classified in four groups: COPD, COPD and LC, LC without COPD, and control with neither COPD nor LC. Proteins were separated into spots by bidimensional polyacrylamide gel electrophoresis (2D-PAGE) and examined by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF/TOF). A total of 40 proteins were differentially expressed in the LC and/or COPD groups as compared with the control group. Distinct protein profiles were identified and validated for each pathological entity (LC and COPD). The main networks involved were related to inflammatory signalling, free radical scavenging and oxidative stress response, and glycolysis and gluconeogenesis pathways. The most relevant signalling link between LC and COPD was through the NF-κB pathway. In conclusion, the protein profiles identified contribute to elucidate the underlying pathogenic pathways of both diseases, and provide new tools of potential use as biomarkers for the early diagnosis of LC. Sequence coverage. The protein sequence coverage (95%) was estimated for specific proteins by the percentage of matching amino acids from the identified peptides having confidence greater than or equal to 95% divided by the total number of amino acids in the sequence. Ingenuity Pathways Analysis. Mapping of our proteins onto biological pathways and disease networks demonstrated that 22 proteins were linked to inflammatory signalling (p-value: 1.35 10(-08)-1.42 10(-02)), 15 proteins were associated with free radical scavenging and oxidative stress response (p-value: 4.93 10(-11)-1.27 10(-02)), and 9 proteins were related with glycolysis and gluconeogenesis pathways (p-value: 7.39 10(-09)-1.58 10(-02)). Copyright © 2013 Elsevier B.V. All rights reserved.

GPR39 (zinc receptor) knockout mice exhibit depression-like behavior and CREB/BDNF down-regulation in the hippocampus.

PubMed

Młyniec, Katarzyna; Budziszewska, Bogusława; Holst, Birgitte; Ostachowicz, Beata; Nowak, Gabriel

2014-10-31

Zinc may act as a neurotransmitter in the central nervous system by activation of the GPR39 metabotropic receptors. In the present study, we investigated whether GPR39 knockout would cause depressive-like and/or anxiety-like behavior, as measured by the forced swim test, tail suspension test, and light/dark test. We also investigated whether lack of GPR39 would change levels of cAMP response element-binding protein (CREB),brain-derived neurotrophic factor (BDNF) and tropomyosin related kinase B (TrkB) protein in the hippocampus and frontal cortex of GPR39 knockout mice subjected to the forced swim test, as measured by Western-blot analysis. In this study, GPR39 knockout mice showed an increased immobility time in both the forced swim test and tail suspension test, indicating depressive-like behavior and displayed anxiety-like phenotype. GPR39 knockout mice had lower CREB and BDNF levels in the hippocampus, but not in the frontal cortex, which indicates region specificity for the impaired CREB/BDNF pathway (which is important in antidepressant response) in the absence of GPR39. There were no changes in TrkB protein in either structure. In the present study, we also investigated activity in the hypothalamus-pituitary-adrenal axis under both zinc- and GPR39-deficient conditions. Zinc-deficient mice had higher serum corticosterone levels and lower glucocorticoid receptor levels in the hippocampus and frontal cortex. There were no changes in the GPR39 knockout mice in comparison with the wild-type control mice, which does not support a role of GPR39 in hypothalamus-pituitary-adrenal axis regulation. The results of this study indicate the involvement of the GPR39 Zn(2+)-sensing receptor in the pathophysiology of depression with component of anxiety. © The Author 2015. Published by Oxford University Press on behalf of CINP.

STS-112 Atlantis Launch from LC-39B

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- The brilliance of the launch of Space Shuttle Atlantis is reflected in nearby waters. Liftoff of the Shuttle on mission STS-112 occurred on time at 3:46 p.m. EDT. Along with a crew of six, Atlantis carries the S1 Integrated Truss Structure and the Crew and Equipment Translation Aid (CETA) Cart A. The CETA is the first of two human-powered carts that will ride along the ISS railway, providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss. [Photo courtesy of Scott Andrews

STS-112 Atlantis Launch from LC-39B

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- Twin columns of white flames from the solid rocket boosters propel Space Shuttle Atlantis toward space after an on-time liftoff of 3:46 p.m. EDT on mission STS-112. Along with a crew of six, Atlantis carries the S1 Integrated Truss Structure and the Crew and Equipment Translation Aid (CETA) Cart A. The CETA is the first of two human-powered carts that will ride along the ISS railway, providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss. [Photo courtesy of Scott Andrews

STS-112 Atlantis Launch from LC-39B

NASA Technical Reports Server (NTRS)

2002-01-01

KENNEDY SPACE CENTER, FLA. -- Rising clouds of smoke and steam appear to surround Space Shuttle Atlantis as it hurtles toward space on mission STS-112. Liftoff occurred on time at 3:46 p.m. EDT. Along with a crew of six, Atlantis carries the S1 Integrated Truss Structure and the Crew and Equipment Translation Aid (CETA) Cart A. The CETA is the first of two human-powered carts that will ride along the ISS railway, providing mobile work platforms for future spacewalking astronauts. On the 11-day mission, three spacewalks are planned to attach the S1 truss. [Photo courtesy of Scott Andrews

Stallion Site, San Marcial, New Mexico. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A, C through F.

DTIC Science & Technology

1975-02-21

3.9 S AA* .. aL __ LL J.2 WNW aL ..2. 6. . a _ L. mVm . -IAi . 1i.-4 L 1 TOMA NIU Of OUATIONS 6 USAFOAC Pm045 (OL.A) PUviOU WmfiO op Ums porn . ANS...a0l4 2i- ; lC i S 14 1 420 1 2* 2 4 As 3K sil .il ,4 , 3 2 h 33 | ’J sUtil il t l I I ! li Ito: a 84/32 bL "..., Iop .ha , erol Boy . L_- I"’SOW ,(4 I 01

STS-33 Discovery, OV-103, early morning liftoff from KSC LC Pad 39B

NASA Image and Video Library

1989-11-22

STS033-S-002 (22 Nov 1989) --- The Space Shuttle Discovery heads for Earth orbit on the first post-Challenger nocturnal launch. Liftoff occurred at 7:23:29:989 p.m. (EST), November 22, 1989. This picture shows a side view of Discovery, one of its two solid rocket boosters (SRB) and the external tank. It represents a good example of the "diamond shock" effect, in the plume from the main engine, associated with Shuttle launches. Onboard for the DOD-devoted mission were Astronauts Frederick D. Gregory, John E. Blaha, F. Story Musgrave, Kathryn C. Thornton and Manley L. Carter.

Evidence for a Structure-Mapping Theory of Analogy and Metaphor

DTIC Science & Technology

1986-12-01

Results: Mean Number of Peiae B1 0~ T2 > B2 n~ Ti Bl n~ T2 = .038 B2 n~ TI .025 NS B > T B= .16 T=l. CA NS Bl >B2 BI .58 B2 =.58 NS T2 > Ti T2 .49 T1 .50...NS B > T B = .63 T = .59 F. B1 > B2 B1 = .37 B2 = .28 NS T2 > T1 T2 = .23 Ti = .39 NS I Bl > T1 B = .37 T1 = .39 NS T2 > B2 T2 =.23 B2 .28 NS a...iption Ti = N in top half of target description T2 = N in bottom half of target description B1 A3 T2 = N in both top half of base and I bcttom half

Classical autophagy proteins LC3B and ATG4B facilitate melanosome movement on cytoskeletal tracks.

PubMed

Ramkumar, Amrita; Murthy, Divya; Raja, Desingu Ayyappa; Singh, Archana; Krishnan, Anusha; Khanna, Sangeeta; Vats, Archana; Thukral, Lipi; Sharma, Pushkar; Sivasubbu, Sridhar; Rani, Rajni; Natarajan, Vivek T; Gokhale, Rajesh S

2017-08-03

Macroautophagy/autophagy is a dynamic and inducible catabolic process that responds to a variety of hormonal and environmental cues. Recent studies highlight the interplay of this central pathway in a variety of pathophysiological diseases. Although defective autophagy is implicated in melanocyte proliferation and pigmentary disorders, the mechanistic relationship between the 2 pathways has not been elucidated. In this study, we show that autophagic proteins LC3B and ATG4B mediate melanosome trafficking on cytoskeletal tracks. While studying melanogenesis, we observed spatial segregation of LC3B-labeled melanosomes with preferential absence at the dendritic ends of melanocytes. This LC3B labeling of melanosomes did not impact the steady-state levels of these organelles but instead facilitated their intracellular positioning. Melanosomes primarily traverse on microtubule and actin cytoskeletal tracks and our studies reveal that LC3B enables the assembly of microtubule translocon complex. At the microtubule-actin crossover junction, ATG4B detaches LC3B from melanosomal membranes by enzymatic delipidation. Further, by live-imaging we show that melanosomes transferred to keratinocytes lack melanocyte-specific LC3B. Our study thus elucidates a new role for autophagy proteins in directing melanosome movement and reveal the unconventional use of these proteins in cellular trafficking pathways. Such crosstalk between the central cellular function and housekeeping pathway may be a crucial mechanism to balance melanocyte bioenergetics and homeostasis.

E1-Like Activating Enzyme Atg7 Is Preferentially Sequestered into p62 Aggregates via Its Interaction with LC3-I

PubMed Central

Gao, Wentao; Chen, Zhixia; Wang, Wei; Stang, Michael T.

2013-01-01

p62 is constitutively degraded by autophagy via its interaction with LC3. However, the interaction of p62 with LC3 species in the context of the LC3 lipidation process is not specified. Further, the p62-mediated protein aggregation’s effect on autophagy is unclear. We systemically analyzed the interactions of p62 with all known Atg proteins involved in LC3 lipidation. We find that p62 does not interact with LC3 at the stages when it is being processed by Atg4B or when it is complexed or conjugated with Atg3. p62 does interact with LC3-I and LC3-I:Atg7 complex and is preferentially recruited by LC3-II species under autophagic stimulation. Given that Atg4B, Atg3 and LC3-Atg3 are indispensable for LC3-II conversion, our study reveals a protective mechanism for Atg4B, Atg3 and LC3-Atg3 conjugate from being inappropriately sequestered into p62 aggregates. Our findings imply that p62 could potentially impair autophagy by negatively affecting LC3 lipidation and contribute to the development of protein aggregate diseases. PMID:24023838

E1-like activating enzyme Atg7 is preferentially sequestered into p62 aggregates via its interaction with LC3-I.

PubMed

Gao, Wentao; Chen, Zhixia; Wang, Wei; Stang, Michael T

2013-01-01

p62 is constitutively degraded by autophagy via its interaction with LC3. However, the interaction of p62 with LC3 species in the context of the LC3 lipidation process is not specified. Further, the p62-mediated protein aggregation's effect on autophagy is unclear. We systemically analyzed the interactions of p62 with all known Atg proteins involved in LC3 lipidation. We find that p62 does not interact with LC3 at the stages when it is being processed by Atg4B or when it is complexed or conjugated with Atg3. p62 does interact with LC3-I and LC3-I:Atg7 complex and is preferentially recruited by LC3-II species under autophagic stimulation. Given that Atg4B, Atg3 and LC3-Atg3 are indispensable for LC3-II conversion, our study reveals a protective mechanism for Atg4B, Atg3 and LC3-Atg3 conjugate from being inappropriately sequestered into p62 aggregates. Our findings imply that p62 could potentially impair autophagy by negatively affecting LC3 lipidation and contribute to the development of protein aggregate diseases.

KSC-04pd0664

NASA Image and Video Library

2004-03-26

CAPE CANAVERAL, Fla. -- This aerial photo shows the expanse of the Launch Complex 39 Area, bordered on the east by the Atlantic Ocean and cloud-filled sky. At center right, towering above the surrounding sites, is the Vehicle Assembly Building. To the left, or north, is the Orbiter Processing Facility’s Bay 3. On the western side are OPF Bays 1 and 2. In the lower right corner is the Operations Support Building. The two-lane crawlerway stretches from the VAB toward the coast, site of Launch Pad 39A, closest, and Launch Pad 39B, far left. Between the VAB and the ocean sprawl the Banana Creek and the Banana River. The turn basin, at right, allows delivery of external tanks that are offloaded close to and transported to the VAB. Photo credit: NASA

Detail view of the vertical stabilizer of the Orbiter Discovery ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Detail view of the vertical stabilizer of the Orbiter Discovery as it sits at Launch Complex 39 A at Kennedy Space Center being prepared for its launch. - Space Transportation System, Orbiter Discovery (OV-103), Lyndon B. Johnson Space Center, 2101 NASA Parkway, Houston, Harris County, TX

78 FR 30940 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-23

... POSTAL REGULATORY COMMISSION [Docket Nos. MC2013-50 and CP2013-63; Order No. 1719] New Postal... contemporaneously filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract...

77 FR 70489 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-26

... POSTAL REGULATORY COMMISSION [Docket No. MC2013-18 and CP2013-17; Order No. 1544] New Postal... redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015.5. Id...' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract; Attachment C...

77 FR 47885 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-10

... POSTAL REGULATORY COMMISSION [Docket Nos. MC2012-36 and CP2012-44; Order No. 1422] New Postal... new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015.5. Id. Attachment B. The instant contract has... attachments as follows: Attachment A--a redacted copy of Governors' Decision No. 11-6, authorizing the new...

78 FR 43245 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-19

... POSTAL REGULATORY COMMISSION [Docket Nos. MC2013-55 and CP2013-73; Order No. 1777] New Postal... contemporaneously filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract...

77 FR 70491 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-26

... POSTAL REGULATORY COMMISSION [Docket No. MC2013-17 and CP2013-16; Order No. 1543] New Postal... redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015.5. Id...' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract; Attachment C...

78 FR 36795 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-19

... POSTAL REGULATORY COMMISSION [Docket Nos. MC2013-52 and CP2013-66; Order No. 1747] New Postal... contemporaneously filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract...

77 FR 70488 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-26

... POSTAL REGULATORY COMMISSION [Docket No. MC2013-20 and CP2013-19; Order No.1546] New Postal... filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract...

78 FR 79025 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-27

... POSTAL REGULATORY COMMISSION [Docket Nos. MC2014-13 and CP2014-17; Order No. 1920] New Postal... redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015.5. Id...' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract; Attachment C...

78 FR 65014 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-30

... POSTAL REGULATORY COMMISSION [Docket No. MC2014-3 and CP2014-3; Order No. 1860] New Postal Product... filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract...

78 FR 79022 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-27

... POSTAL REGULATORY COMMISSION [Docket Nos. MC2014-12 and CP2014-16; Order No. 1919] New Postal... proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015.5. Id. Attachment B. The instant contract... attachments as follows: Attachment A--a redacted copy of Governors' Decision No. 11-6, authorizing the new...

77 FR 70490 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-26

... POSTAL REGULATORY COMMISSION [Docket No. MC2013-19 and CP2013-18; Order No. 1545] New Postal... redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015.5. Id...' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract; Attachment C...

Unmanned Aircraft Systems for Logistics Applications

DTIC Science & Technology

2011-01-01

Jane’s Air-Launched Weapons, “ GBU - 39 /B Small Diameter Bomb (SDB) and SDB II (United States),” June 5, 2009. As of September 11, 2009: http...www.janes.com/articles/Janes-Air-Launched-Weapons/ GBU - 39 -B-Small- Diameter-Bomb-SDB-and-SDB-II-United-States.html [subscription required] Jane’s Electro

75 FR 11422 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-11

... Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by reference, Safety. Adoption of... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY...

75 FR 61348 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-05

... CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by reference, Safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY...

76 FR 38065 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-29

.... Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY: Federal Aviation Administration (FAA... Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by reference, Safety. The Proposed... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011...

75 FR 31324 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-03

.... Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY: Federal Aviation Administration (FAA... Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by reference, Safety. The Proposed... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010...

77 FR 42778 - Product List Change

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-20

... proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015.5. Id. Attachment B. The instant contract... POSTAL REGULATORY COMMISSION [Docket Nos. MC2012-34 and CP2012-42; Order No. 1405] Product List... recently-filed Postal Service request to add Parcel Select Contract 5 to the competitive product list. This...

77 FR 42779 - Product List Change

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-20

... proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015.5. Id. Attachment B. The instant contract... POSTAL REGULATORY COMMISSION [Docket Nos. MC2012-33 and CP2012-41; Order No. 1404] Product List... recently-filed Postal Service request to add Parcel Select Contract 4 to the competitive product list. This...

77 FR 42515 - Product List Change

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-19

... redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015.5. Id...' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract; Attachment C... POSTAL REGULATORY COMMISSION [Docket Nos. MC2012-32 and CP2012-40; Order No. 1403] Product List...

25 CFR 39.105 - Are additional funds available for special education?

Code of Federal Regulations, 2011 CFR

2011-04-01

... with Disabilities Education Act (IDEA). To obtain part B funds, the school must submit an application to OIEP. IDEA funds are available only if the school demonstrates that funds reserved under § 39.104...) The Bureau will facilitate the delivery of IDEA part B funding by: (1) Providing technical assistance...

77 FR 65589 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-29

... contemporaneously filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket Nos. MC2013-10 and CP2013-10; Order No. 1513] New Postal...

78 FR 55125 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-09

... contemporaneously filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket No. MC2013-58 and CP2013-79; Order No. 1825] New Postal...

78 FR 6358 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

... contemporaneously filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket No. MC2013-35 and CP2013-46; Order No. 1636] New Postal...

77 FR 66191 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-02

... redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015.5. Id...' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract; Attachment C... POSTAL REGULATORY COMMISSION [Docket No. MC2013-12 and CP2013-12; Order No. 1520] New Postal...

78 FR 6359 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

... contemporaneously filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket No. MC2013-33 and CP2013-44; Order No. 1634] New Postal...

77 FR 65588 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-29

... filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket Nos. MC2013-11 and CP2013-11; Order No. 1514] New Postal...

78 FR 4173 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-18

... contemporaneously filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket No. MC2013-32 and CP2013-41; Order No. 1622] New Postal...

77 FR 65590 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-29

... contemporaneously filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket Nos. MC2013-9 and CP2013-9; Order No. 1512] New Postal...

78 FR 4174 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-18

... contemporaneously filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket No. MC2013-31 and CP2013-40; Order No. 1621] New Postal...

77 FR 76093 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-26

... redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015.5. Id... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket Nos. MC2013-23 and CP2013-31; Order No. 1585] New Postal...

78 FR 8597 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-06

... contemporaneously filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket No. MC2013-36 and CP2013-47; Order No. 1644] New Postal...

78 FR 8598 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-06

... contemporaneously filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket No. MC2013-37 and CP2013-48; Order No. 1645] New Postal...

77 FR 65588 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-29

... filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket Nos. MC2013-8 and CP2013-8; Order No. 1511] New Postal...

77 FR 76570 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-28

... filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket No. MC2013-26 and CP2013-34; Order No. 1590] New Postal...

77 FR 76092 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-26

... contemporaneously filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket Nos. MC2013-21 and CP2013-29; Order No. 1583] New Postal...

77 FR 76571 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-28

... filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket No. MC2013-25 and CP2013-33; Order No. 1589] New Postal...

77 FR 76094 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-26

... redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015.5. Id...' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract; Attachment C... POSTAL REGULATORY COMMISSION [Docket Nos. MC2013-22 and CP2013-30; Order No. 1584] New Postal...

77 FR 66192 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-02

... contemporaneously filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket No. MC2013-13 and CP2013-13; Order No. 1521] New Postal...

39 CFR 3050.25 - Volume and revenue data.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 39 Postal Service 1 2011-07-01 2011-07-01 false Volume and revenue data. 3050.25 Section 3050.25 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL PERIODIC REPORTING § 3050.25 Volume and revenue data. (a) The items in paragraphs (b) through (e) of this section shall be provided. (b) The Revenue...

75 FR 71353 - Airworthiness Directives; Mitsubishi Heavy Industries, Ltd. Various Models MU-2B Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-23

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009-1076; Directorate Identifier 2009-CE-019-AD; Amendment 39-16296; AD 2010-10-17] RIN 2120-AA64 Airworthiness Directives; Mitsubishi Heavy Industries, Ltd. Various Models MU-2B Airplanes AGENCY: Federal...

Membrane-associated precursor to poliovirus VPg identified by immunoprecipitation with antibodies directed against a synthetic heptapeptide

DOE Office of Scientific and Technical Information (OSTI.GOV)

Semelr, B.L.; Anderson, C.W.; Hanecak, R.

1982-02-01

A synthetic heptapeptide corresponding to the C-terminal sequence of the poliovirus genome protein (VPg) has been linked to bovine serum albumin and used to raise antibodies in rabbits. These antibodies precipitate not only VPg but also at least two more virus-specific polypeptides. The smaller polypeptide, denoted P3-9 (12,000 daltons), has been mapped by Edman degradation and by fragmentation with cyanogen bromide and determined to be the N-terminal cleavage product of polypeptide P3-1b, a precursor to the RNA polymerase. P3-9 contains the sequence of the basic protein VPg (22 amino acids) at its C terminus. As predicted by the known RNAmore » sequence of poliovirus, P3-9 also contains a hydrophobic region of 22 amino acids preceding VPg, an observation suggesting that P3-9 may be membrane-associated. This was confirmed by fractionation of infected cells in the presence or absence of detergent. We speculate that P3-9 may be the donor of VPg to RNA chains in the membrane-bound RNA replication complex.« less

Environmental Control Subsystem Development

NASA Technical Reports Server (NTRS)

Laidlaw, Jacob; Zelik, Jonathan

2017-01-01

Kennedy Space Center's Launch Pad 39B, part of Launch Complex 39, is currently undergoing construction to prepare it for NASA's Space Launch System missions. The Environmental Control Subsystem, which provides the vehicle with an air or nitrogen gas environment, required development of its local and remote display screens. The remote displays, developed by NASA contractors and previous interns, were developed without complete functionality; the remote displays were revised, adding functionality to over 90 displays. For the local displays, multiple test procedures were developed to assess the functionality of the screens, as well as verify requirements. One local display screen was also developed.

Pad 39B Flame Trench Upgrades and modifications

NASA Image and Video Library

2016-03-03

Upgrades and modifications continue to the flame trench at Launch Pad 39B at NASA’s Kennedy Space Center in Florida. Pad B is being refurbished to support the launch of NASA’s Space Launch System rocket. The Ground Systems Development and Operations (GSDO) Program at Kennedy is helping transform the space center into a multi-user spaceport and prepare for Exploration Mission-1, deep-space missions, and the journey to Mars.

Fourier-transform spectroscopy and coupled-channels deperturbation treatment of the A1Σ+-b3Π complex of KCs

NASA Astrophysics Data System (ADS)

Kruzins, A.; Klincare, I.; Nikolayeva, O.; Tamanis, M.; Ferber, R.; Pazyuk, E. A.; Stolyarov, A. V.

2010-04-01

The laser-induced fluorescence (LIF) A1Σ+-b3Π→X1Σ+ spectra of the KCs molecule were recorded in a near infrared region by a Fourier-transform spectrometer with a resolution of 0.03 cm-1. Overall more than 200 collisionally enhanced LIF spectra were rotationally assigned to K39Cs133 and K41Cs133 isotopomers yielding more than 3400 rovibronic term values of the strongly mixed singlet A1Σ+ and triplet b3Π states with the uncertainty of 0.003-0.01 cm-1. Experimental data massive starts from the lowest vibrational level vA=0 of the singlet and nonuniformly covers the energy range E∈[10040,13250] cm-1 with rotational quantum numbers J'∈[7,225]. Besides the dominating regular A1Σ+-b3ΠΩ=0 interactions, the weak local heterogeneous A1Σ+-b3ΠΩ=1 perturbations have been discovered and analyzed. Coupled-channels deperturbation analysis of the experimental K39Cs133 e-parity term values of the A1Σ+-b3ΠΩ=0,1,2 complex was accomplished in the framework of the phenomenological 4×4 Hamiltonian accounting implicitly for regular interactions with the remote 1Π and 3Σ+ states. The diabatic potential energy curves of the A1Σ+ and b3Π states, as well as relevant spin-orbit coupling matrix elements, were defined analytically with the expanded Morse oscillators model. The obtained parameters reproduce 95% of experimental data field of the K39Cs133 isotopomer with a standard deviation of 0.004 cm-1, which is consistent with the uncertainty of the experiment. Reliability of the derived parameters was confirmed by a good agreement between the predicted and experimental term values of the K41Cs133 isotopomer. The calculated relative intensity distributions in A-b→X LIF progressions are also consistent with their experimental counterparts. The deperturbation model was applied for simulation of a pump-dump optical cycle a3Σ+→A1Σ+-b3Π→X1Σ+ proposed for transformation of ultracold KCs molecules to their absolute ground state vX=0;JX=0.

Army Command and Control Study - 82 (ACCS-82). Volume I. Executive Summary and Study Report.

DTIC Science & Technology

1979-09-30

36H 7.9 .409 7.9 .409 Sul -rOTAL iuo.4 .904 .946 .9Y4 1.u53 1.079 4 10.6 42.1 045 4.1 .183 4.9 219 4 .4 .196 5.5 .245 6.5 .290 25 .154 2.6 .160 4.1 .252...100.0 b 39.4 (1) 44.1 .044 3.9 .173 3.9 .173 6.4 .214 7.1 .315 7.4 .328 (2) b5.9 .056 0.5 .19? 3.2 .180 b. .2yu 6.5 .36b 6.8 .382 SUl -7OTAL 100.0 100.0...PLANNERS + 162.6 - + 18.0 + 180.6 CORPS RIO -AFFILIA- TION + 89.2 - + 10.4 + 99.6 DIV R/O-AFFILIATION + 446.1 - + 52.1 + 498.2 INSTALLATION MOB + 624.5

17 CFR 39.27 - Legal risk considerations.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false Legal risk considerations. 39... CLEARING ORGANIZATIONS Compliance with Core Principles § 39.27 Legal risk considerations. (a) Legal... by the appropriate foreign licensing authority. (b) Legal framework. A derivatives clearing...

View of Mission Control on first day of ASTP docking in Earth orbit

NASA Technical Reports Server (NTRS)

1975-01-01

An overall view of the Mission Operations Control Room in the Mission Control Center, bldg 30, JSC, on the first day of the Apollo Soyuz Test Project (ASTP) docking in Earth orbit. This photograph was taken shortly before the American ASTP launch from the Kennedy Space Center. The television monitor in the center background shows the ASTP Apollo-Saturn 1B space vehicle on Pad B at KSC's Launch Complex 39.

A sensitive LC-MS/MS method for the quantification of urinary 8-iso-prostaglandin F2α (8-iso-PGF2α) including pediatric reference interval.

PubMed

Xiao, Yi; Fu, Xiaowei; Pattengale, Paul; Dien Bard, Jennifer; Xu, Yan-Kang; O'Gorman, Maurice R

2016-09-01

Oxidative stress has been implicated in numerous diseases, including arthritis, atherosclerosis, Alzheimer's disease, cancer, diabetes, hypertension, and inflammation. 8-iso-prostaglandin F2α, a member of the F2 isoprostane family, has been well-accepted as a valuable biomarker for the assessment of oxidative stress. We report the development and validation of an ultra-sensitive LC-MS/MS assay for urinary 8-iso-PGF2α measurements in pediatric population. The assay was linear from 0.024 to 20nmol/l (R(2)=0.99). Recoveries were above 85% and matrix effects were below 5%. The variability was determined at nmol/l concentration: the intra-day variability (%CV) ranged from 3.9% to 4.5% (n=20); and the inter-day variability ranged from 4.3% to 5.7% (n=20). The accuracy of our laboratory developed test was evaluated with a clinical reference laboratory (n=39), and a correlation coefficient of 0.9257 was observed. Reference interval were established to be <0.5ng/mg creatinine in a group of pediatric population (2months-18years, n=123). The precision of the assay will allow for accurate assessment of oxidative stress, and is acceptable for patient testing, particularly in pediatric population. Copyright © 2016 Elsevier B.V. All rights reserved.

41. Photocopy of engineering drawing. LC17B LONG TANK DELTA UPBUILD ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

41. Photocopy of engineering drawing. LC-17B LONG TANK DELTA UPBUILD UMBILICAL MAST: ELEVATIONS AND DETAILS, MECHANICAL, APRIL 1969 - Cape Canaveral Air Station, Launch Complex 17, Facility 28402, East end of Lighthouse Road, Cape Canaveral, Brevard County, FL

Activation of MyD88 Signaling upon Staphylococcal Enterotoxin Binding to MHC Class II Molecules

DTIC Science & Technology

2011-01-20

TCCTGTGGCATCCACGA- AACT-39; Reverse 59-GAAGCATTTGCGGTGGACGAT-39), TNF-a (Forward 59- CGG GAC GTG GAG CTG GCC GAG G- AG-39; Reverse 59-CAC CAG CTG GTT...Biol Chem 273: 12203–12209. 38. Gray P, Dunne A, Brikos C, Jefferies CA, Doyle SL, et al. (2006) MyD88 adapter-like (Mal) is phosphorylated by Bruton’s...stimulate nuclear translocation of PKC in B lymphocytes. Nature 327: 629–632. 42. Barr TA, Brown S, Mastroeni P, Gray D (2009) B cell intrinsic MyD88

Crystallization and preliminary X-ray diffraction analysis of the CRISPR-Cas RNA-silencing Cmr complex.

PubMed

Osawa, Takuo; Inanaga, Hideko; Numata, Tomoyuki

2015-06-01

Clustered regularly interspaced short palindromic repeat (CRISPR)-derived RNA (crRNA) and CRISPR-associated (Cas) proteins constitute a prokaryotic adaptive immune system (CRISPR-Cas system) that targets and degrades invading genetic elements. The type III-B CRISPR-Cas Cmr complex, composed of the six Cas proteins (Cmr1-Cmr6) and a crRNA, captures and cleaves RNA complementary to the crRNA guide sequence. Here, a Cmr1-deficient functional Cmr (CmrΔ1) complex composed of Pyrococcus furiosus Cmr2-Cmr3, Archaeoglobus fulgidus Cmr4-Cmr5-Cmr6 and the 39-mer P. furiosus 7.01-crRNA was prepared. The CmrΔ1 complex was cocrystallized with single-stranded DNA (ssDNA) complementary to the crRNA guide by the vapour-diffusion method. The crystals diffracted to 2.1 Å resolution using synchrotron radiation at the Photon Factory. The crystals belonged to the triclinic space group P1, with unit-cell parameters a = 75.5, b = 76.2, c = 139.2 Å, α = 90.3, β = 104.8, γ = 118.6°. The asymmetric unit of the crystals is expected to contain one CmrΔ1-ssDNA complex, with a Matthews coefficient of 2.03 Å(3) Da(-1) and a solvent content of 39.5%.

41 CFR 101-39.202 - Contractor authorized services.

Code of Federal Regulations, 2010 CFR

2010-07-01

... VEHICLES 39-INTERAGENCY FLEET MANAGEMENT SYSTEMS 39.2-GSA Interagency Fleet Management System Services... related GSA Interagency Fleet Management System (IFMS) services solely for official purposes. (b) To the... -leased equipment which is not controlled by a GSA IFMS fleet management center, or for authorized...

The wheat transcription factor, TabHLH39, improves tolerance to multiple abiotic stressors in transgenic plants.

PubMed

Zhai, Yiqian; Zhang, Lichao; Xia, Chuan; Fu, Silu; Zhao, Guangyao; Jia, Jizeng; Kong, Xiuying

2016-05-13

Although bHLH transcription factors play important roles regulating plant development and abiotic stress response and tolerance, few functional studies have been performed in wheat. In this study, we isolated and characterized a bHLH gene, TabHLH39, from wheat. The TabHLH39 gene is located on wheat chromosome 5DL, and the protein localized to the nucleus and activated transcription. TabHLH39 showed variable expression in roots, stems, leaves, glumes, pistils and stamens and was induced by polyethylene glycol, salt and cold treatments. Further analysis revealed that TabHLH39 overexpression in Arabidopsis significantly enhanced tolerance to drought, salt and freezing stress during the seedling stage, which was also demonstrated by enhanced abiotic stress-response gene expression and changes to several physiological indices. Therefore, TabHLH39 has potential in transgenic breeding applications to improve abiotic stress tolerance in crops. Copyright © 2016 Elsevier Inc. All rights reserved.

Temporal Association of HLA-B*81:01- and HLA-B*39:10-Mediated HIV-1 p24 Sequence Evolution with Disease Progression

PubMed Central

Ntale, R. S.; Chopera, D. R.; Ngandu, N. K.; Assis de Rosa, D.; Zembe, L.; Gamieldien, H.; Mlotshwa, M.; Werner, L.; Woodman, Z.; Mlisana, K.; Abdool Karim, S.; Gray, C. M.

2012-01-01

HLA-B*81:01 and HLA-B*39:10 alleles have been associated with viremic control in HIV-1 subtype C infection. Both alleles restrict the TL9 epitope in p24 Gag, and cytotoxic-T-lymphocyte (CTL)-mediated escape mutations in this epitope have been associated with an in vitro fitness cost to the virus. We investigated the timing and impact of mutations in the TL9 epitope on disease progression in five B*81:01- and two B*39:10-positive subtype C-infected individuals. Whereas both B*39:10 participants sampled at 2 months postinfection had viruses with mutations in the TL9 epitope, in three of the five (3/5) B*81:01 participants, TL9 escape mutations were only detected 10 months after infection, taking an additional 10 to 15 months to reach fixation. In the two remaining B*81:01 individuals, one carried a TL9 escape variant at 2 weeks postinfection, whereas no escape mutations were detected in the virus from the other participant for up to 33 months postinfection, despite CTL targeting of the epitope. In all participants, escape mutations in TL9 were linked to coevolving residues in the region of Gag known to be associated with host tropism. Late escape in TL9, together with coevolution of putative compensatory mutations, coincided with a spontaneous increase in viral loads in two individuals who were otherwise controlling the infection. These results provide in vivo evidence of the detrimental impact of B*81:01-mediated viral evolution, in a single Gag p24 epitope, on the control of viremia. PMID:22933291

Design, synthesis, and characterization of a 39 amino acid peptide mimic of the main immunogenic region of the Torpedo acetylcholine receptor.

PubMed

Trinh, Vu B; Foster, Alex J; Fairclough, Robert H

2014-05-01

We have designed a 39 amino acid peptide mimic of the conformation-dependent main immunogenic region (MIR) of the Torpedo acetylcholine receptor (TAChR) that joins three discontinuous segments of the Torpedo α-subunit, α(1-12), α(65-79), and α(110 - 115) with two GS linkers: This 39MIR-mimic was expressed in E. coli as a fusion protein with an intein-chitin-binding domain (IChBD) to permit affinity collection on chitin beads. Six MIR-directed monoclonal antibodies (mAbs) bind to this complex and five agonist/antagonist site directed mAbs do not. The complex of MIR-directed mAb-132A with 39MIR has a Kd of (2.11±0.11)×10(-10)M, which is smaller than (7.13±1.20)×10(-10)M for the complex of mAb-132A with α(1-161) and about the same as 3.4×10(-10)M for that of mAb-132A with TAChR. Additionally, the 39MIR-IChBD adsorbs all MIR-directed antibodies (Abs) from an experimental autoimmune myasthenia gravis (EAMG) rat serum. Hence, the 39MIR-mimic has the potential to inactivate or remove pathogenic Torpedo MIR-directed Abs from EAMG sera and to direct a magic bullet to the memory B-cells that produce those pathogenic Abs. The hope is to use this as a guide to produce a mimic of the human MIR on the way to an antigen specific therapeutic agent to treat MG. Copyright © 2014 Elsevier Ltd. All rights reserved.

77 FR 305 - New Postal Product

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-04

... POSTAL REGULATORY COMMISSION [Docket Nos. MC2012-4 and CP2012-8; Order No. 1073] New Postal...), as well as a new GEPS-NPR 3 model contract and accompanying financial model that differ from the GEPS... to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015.5. Id. Attachment B. The...

75 FR 25788 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-10

.... Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY: Federal Aviation Administration (FAA.... List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010...

75 FR 37708 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-30

.... List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY...

75 FR 64636 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-20

... docket. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY...

75 FR 63054 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-14

.... List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY...

76 FR 8605 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 and 440...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-15

... after receipt. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 and 440) Airplanes AGENCY...

75 FR 22521 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-29

... after receipt. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY...

75 FR 17086 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B19 (Regional Jet Series 100 & 440...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-05

.... Model CL-600-2B19 (Regional Jet Series 100 & 440) Airplanes AGENCY: Federal Aviation Administration (FAA... the AD docket. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010...

77 FR 63899 - New Postal Product; Negotiated Service Agreement

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-17

... redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015.5. Id...' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract; Attachment C... POSTAL REGULATORY COMMISSION [Docket Nos. MC2013-2 and CP2013-2; Order No. 1493] New Postal...

77 FR 65232 - New Postal Product and Related Negotiated Service Agreement

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-25

... filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015... Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy of the contract... POSTAL REGULATORY COMMISSION [Docket Nos. MC2013-7 and CP2013-7; Order No. 1507] New Postal...

77 FR 65231 - New Postal Product and Related Negotiated Service Agreement

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-25

... filed a redacted contract related to the proposed new product under 39 U.S.C. 3632(b)(3) and 39 CFR 3015... redacted copy of Governors' Decision No. 11-6, authorizing the new product; Attachment B--a redacted copy... POSTAL REGULATORY COMMISSION [Docket Nos. MC2013-6 and CP2013-6; Order No. 1506] New Postal...

75 FR 32266 - Airworthiness Directives; Airbus Model A300 Series Airplanes; Airbus Model A300 B4-600, B4-600R...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... after receipt. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Transportation (DOT). ACTION: Final rule. SUMMARY: We are adopting a new airworthiness directive (AD) for the...

76 FR 39248 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-06

... after receipt. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Final rule...

STS-108 Endeavour Launch from Pad 39-B

NASA Technical Reports Server (NTRS)

2001-01-01

STS-108 Endeavour Launch from Pad 39-B KSC-01PD-1788 KENNEDY SPACE CENTER, Fla. -- A pool of water near Launch Pad 39B turns crimson from the reflection of flames at the launch of Space Shuttle Endeavour on mission STS-109. The second attempt in two days, liftoff occurred at 5:19:28 p.m. EST (10:19.28 GMT). Endeavour will dock with the International Space Station on Dec. 7. STS-108 is the final Shuttle mission of 2001and the 107th Shuttle flight overall. It is the 12th flight to the Space Station. Landing of the orbiter at KSC's Shuttle Landing Facility is targeted for 1:05 p.m. EST (6:05 p.m. GMT) Dec. 16.

Crew Launch Vehicle Mobile Launcher Solid Rocket Motor Plume Induced Environment

NASA Technical Reports Server (NTRS)

Vu, Bruce T.; Sulyma, Peter

2008-01-01

The plume-induced environment created by the Ares 1 first stage, five-segment reusable solid rocket motor (RSRMV) will impose high heating rates and impact pressures on Launch Complex 39. The extremes of these environments pose a potential threat to weaken or even cause structural components to fail if insufficiently designed. Therefore the ability to accurately predict these environments is critical to assist in specifying structural design requirements to insure overall structural integrity and flight safety. This paper presents the predicted thermal and pressure environments induced by the launch of the Crew Launch Vehicle (CLV) from Launch Complex (LC) 39. Once the environments are predicted, a follow-on thermal analysis is required to determine the surface temperature response and the degradation rate of the materials. An example of structures responding to the plume-induced environment will be provided.

STS-90 M.S. Williams with the CSA waves to family and friends near Pad 39B

NASA Technical Reports Server (NTRS)

1998-01-01

STS-90 Mission Specialist Dafydd (Dave) Williams, M.D., with the Canadian Space Agency speaks with friends and family members near Launch Pad 39B, from which he and the rest of the seven-member crew are scheduled to launch aboard Columbia on May 16 at 2:19 p.m. EDT. The astronauts are under strict health stabilization guidelines to protect them from close contact with persons who do not have health stabilization clearance. This is the 25th flight of Columbia and the 90th mission flown since the start of the Space Shuttle program. STS-90 is a nearly 17-day life sciences research flight that will focus on the most complex and least understood part of the human body -- the nervous system. Neurolab will examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body.

STS-90 M.S. Kathryn Hire waves to family and friends near Pad 39B

NASA Technical Reports Server (NTRS)

1998-01-01

STS-90 Mission Specialist Kathryn (Kay) Hire waves to friends and family members near Launch Pad 39B, from which she and the rest of the seven-member crew are scheduled to launch aboard Columbia on May 16 at 2:19 p.m. EDT. The astronauts are under strict health stabilization guidelines to protect them from close contact with persons who do not have health stabilization clearance. This is the 25th flight of Columbia and the 90th mission flown since the start of the Space Shuttle program. STS- 90 is a nearly 17-day life sciences research flight that will focus on the most complex and least understood part of the human body -- the nervous system. Neurolab will examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body.

7 CFR 2902.39 - Floor strippers.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 15 2011-01-01 2011-01-01 false Floor strippers. 2902.39 Section 2902.39 Agriculture Regulations of the Department of Agriculture (Continued) OFFICE OF ENERGY POLICY AND NEW USES, DEPARTMENT OF... mechanical assistance. (b) Minimum biobased content. The preferred procurement product must have a minimum...

40. Photocopy of engineering drawing. LC17B LONG TANK DELTA UPBUILD ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

40. Photocopy of engineering drawing. LC-17B LONG TANK DELTA UPBUILD LAUNCH DECK: NEW PLATE AT LAUNCH MOUNT AREA-STRUCTURAL, APRIL 1969. - Cape Canaveral Air Station, Launch Complex 17, Facility 28402, East end of Lighthouse Road, Cape Canaveral, Brevard County, FL

Center Planning and Development: Multi-User Spaceport Initiatives

NASA Technical Reports Server (NTRS)

Kennedy, Christopher John

2015-01-01

The Vehicle Assembly building at NASAs Kennedy Space Center has been used since 1966 to vertically assemble every launch vehicle, since the Apollo Program, launched from Launch Complex 39 (LC-39). After the cancellation of the Constellation Program in 2010 and the retirement of the Space Shuttle Program in 2011, the VAB faced an uncertain future. As the Space Launch System (SLS) gained a foothold as the future of American spaceflight to deep space, NASA was only using a portion of the VABs initial potential. With three high bays connected to the Crawler Way transportation system, the potential exists for up to three rockets to be simultaneously processed for launch. The Kennedy Space Center (KSC) Master plan, supported by the Center Planning and Development (CPD) Directorate, is guiding Kennedy toward a 21st century multi-user spaceport. This concept will maintain Kennedy as the United States premier gateway to space and provide multi-user operations through partnerships with the commercial aerospace industry. Commercial aerospace companies, now tasked with transporting cargo and, in the future, astronauts to the International Space Station (ISS) via the Commercial Resupply Service (CRS) and Commercial Crew Program (CCP), are a rapidly growing industry with increasing capabilities to make launch operations more economical for both private companies and the government. Commercial operations to Low Earth Orbit allow the government to focus on travel to farther destinations through the SLS Program. With LC-39B designated as a multi-use launch pad, companies seeking to use it will require an integration facility to assemble, integrate, and test their launch vehicle. An Announcement for Proposals (AFP) was released in June, beginning the process of finding a non-NASA user for High Bay 2 (HB2) and the Mobile Launcher Platforms (MLPs). An Industry Day, a business meeting and tour for interested companies and organizations, was also arranged to identify and answer any additional questions posed by potential proposers. After amending the AFP and posting additional material for potential users to consider, proposals are being accepted until July 31, at which point they will be evaluated to determine the proposer which best meets the objectives of the government. By identifying VAB HB2 as available and seeking proposals from the commercial sector for VAB HB2 and MLP use, Center Planning and Development is ensuring Kennedy Space Centers relevance in the evolving launch industry of the 21st century.

39 CFR 3001.5 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... § 3001.5 Definitions. (a) Act means title 39, United States Code, as amended. (b) Postal Service means... 39 Postal Service 1 2013-07-01 2013-07-01 false Definitions. 3001.5 Section 3001.5 Postal Service... post office. (n) Commission meeting means the deliberations of at least three Commissioners where such...

38 CFR 39.12 - Hearings.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Hearings. 39.12 Section... Requirements and Procedures § 39.12 Hearings. (a) No application for a grant to establish, expand, or improve a... hearing. (b) Whenever a hearing is requested under this section, notice of the hearing, procedure for the...

39 CFR 3050.43 - Information on program performance.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) through (3) of this section at the same time that the President submits an annual budget to Congress: (b... 39 U.S.C. 2803; and (3) The program performance reports required by 39 U.S.C. 2804. (c) Section 3050.10 does not apply to the reports referenced in this section. ...

14 CFR 431.39 - Mission rules, procedures, contingency plans, and checklists.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Mission rules, procedures, contingency plans, and checklists. 431.39 Section 431.39 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION... safe conduct of mission operations during nominal and non-nominal vehicle flight. (b) Mission rules...

14 CFR 431.39 - Mission rules, procedures, contingency plans, and checklists.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Mission rules, procedures, contingency plans, and checklists. 431.39 Section 431.39 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION... safe conduct of mission operations during nominal and non-nominal vehicle flight. (b) Mission rules...

22 CFR 213.39 - Exceptions to mandatory transfer.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Exceptions to mandatory transfer. 213.39 Section 213.39 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT CLAIMS COLLECTION Mandatory Transfer... Exceptions to mandatory transfer. USAID is not required to transfer a debt to FMS pursuant to § 213.37(b...

22 CFR 213.39 - Exceptions to mandatory transfer.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Exceptions to mandatory transfer. 213.39 Section 213.39 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT CLAIMS COLLECTION Mandatory Transfer... Exceptions to mandatory transfer. USAID is not required to transfer a debt to FMS pursuant to § 213.37(b...

14 CFR 47.39 - Effective date of registration.

Code of Federal Regulations, 2010 CFR

2010-01-01

... § 47.33 or § 47.35. (b) An aircraft last previously registered in a foreign country is registered under... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Effective date of registration. 47.39 Section 47.39 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT...

Fast Ferroelectric Spatial Light Modulators for Adaptive Optics Applications

DTIC Science & Technology

1999-02-10

distribution unlimited J3TIC QUALITY INSPECTED 2 ^mn 039 18/09 󈨥 12:51 ®071 355 5348 N.R.C.C. LONDON B REPORT DOCUMENTATION PAGE Form...fragment 39. This hindrance has the same nature as it was described by R.B.Meyer et al [8] and is related with the monoclinic surrounding near the...preferable than the state ( b ). The dipolar moments 16, attached to the chiral fragment 39 will have the transverse component along the normal to inclination

Woodpecker Preventative measures at Launch Pad 39B

NASA Technical Reports Server (NTRS)

1995-01-01

Technicians at Launch Pad 39B take steps to prevent further damage from woodpeckers to the Space Shuttle Discovery, set to lift off July 13 on Mission STS-70. Installing balloons with scary eyes, such as these two near the external tank, are just one of the measures being taken to keep woodpeckers away since Discovery's second rollout to Pad B. Discovery had to be rolled back once to the Vehicle Assembly Building to repair woodpecker holes made in the insulation covering the external tank.

76 FR 67051 - Airworthiness Directives; Bell Helicopter Textron, Inc. Model 204B, 205A, 205A-1, 205B, 210, 212...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-31

...-1041; Directorate Identifier 2010-SW-109-AD; Amendment 39-16821; AD 2010-26-52] RIN 2120-AA64... docket number FAA-2011-1041 and Directorate Identifier 2010-SW-109-AD at the beginning of your comments...-52 Bell Helicopter Textron, Inc.: Amendment 39-16821; Docket No. FAA-2011-1041; Directorate...

HLA class I and class II haplotypes in admixed families from several regions of Mexico.

PubMed

Barquera, Rodrigo; Zúñiga, Joaquín; Hernández-Díaz, Raquel; Acuña-Alonzo, Victor; Montoya-Gama, Karla; Moscoso, Juan; Torres-García, Diana; García-Salas, Claudia; Silva, Beatriz; Cruz-Robles, David; Arnaiz-Villena, Antonio; Vargas-Alarcón, Gilberto; Granados, Julio

2008-02-01

We studied HLA class I and class II alleles in 191 Mexican families (381 non-related individuals) to directly obtain the HLA-A/B/DRB1/DQB1 haplotypes and their linkage disequilibrium (LD). The most frequent HLA haplotypes observed were: A*02-B*39-DRB1*04-DQB1*0302, A*02-B*35-DRB1*04-DQB1*0302, A*68-B*39-DRB1*04-DQB1*0302, A*02-B*35-DRB1*08-DQB1*04, A*33-B*1402-DRB1*01-DQB1*05, and A*24-B*35-DRB1*04-DQB1*0302. The four most common haplotypes found by our study involve those previously reported in Amerindian populations. LD analysis of HLA-A-B and HLA-B-DRB1 loci showed significant associations between A29(19)-B44(12), A33(19)-B65(14), A1-B8, A26(19)-B44(12), A24(9)-B61(40), B65(14)-DR1, B8-DR17(3), B44(12)-DR7, B7-DR15(2), and B39(16)-DR4. Also, all DRB1-DQB1 associations showed significant LD values. Admixture estimations using a trihybrid model showed that Mexicans from the State of Sinaloa (Northern Mexico) have a greater proportion of European genetic component compared with Mexicans from the Central area of Mexico, who have a greater percentage of Amerindian genes. Our results are important for future comparative genetic studies of different Mexican ethnic groups with special relevance to disease association and transplantation studies.

STS-32 MS Dunbar looks on as technicians prepare LES equipment in white room

NASA Technical Reports Server (NTRS)

1990-01-01

STS-32 Mission Specialist (MS) Bonnie J. Dunbar, wearing launch and entry suit (LES), looks on as technicians prepare LES equipment in the white room on the orbiter access arm at Kennedy Space Center (KSC) Launch Complex (LC) Pad 39A before entering Columbia, Orbiter Vehicle (OV) 102. In the background, a technician looks through OV-102 side hatch.

View of Apollo 15 space vehicle on way from VAB to Pad A, Launch Complex 39

NASA Image and Video Library

1971-05-11

S71-33781 (11 May 1971) --- High angle view showing the Apollo 15 (Spacecraft 112/Lunar Module 10/Saturn 510) space vehicle on the way from the Vehicle Assembly Building (VAB) to Pad A, Launch Complex 39, Kennedy Space Center (KSC). The Saturn V stack and its mobile launch tower are atop a huge crawler-transporter. Apollo 15 is scheduled as the fourth manned lunar landing mission by the National Aeronautics and Space Administration (NASA). The crew men will be astronauts David R. Scott, commander; Alfred M. Worden, command module pilot; and James B. Irwin, lunar module pilot. While astronauts Scott and Irwin descend in the Lunar Module (LM) to explore the moon, astronaut Worden will remain with the Command and Service Modules (CSM) in lunar orbit.

SKYLAB IV - LAUNCH

NASA Image and Video Library

1973-11-27

S73-37285 (16 Nov. 1973) --- The Skylab 4/Saturn 1B space vehicle is launched from Pad B, Launch Complex 39, Kennedy Space Center, Florida, at 9:01:23 a.m. (EST), Friday, Nov. 16, 1973. Skylab 4 is the third and last of three scheduled manned Skylab missions. Aboard the Skylab 4 Command/Service Module were astronauts Gerald P. Carr, Edward G. Gibson and William R. Pogue. In addition to the CSM and its launch escape system, the Skylab 4 space vehicle consisted of the Saturn 1B first (S-1B) stage and the Saturn 1B second (S-IVB) stage. (The Skylab 1/Saturn V unmanned space vehicle with the space station payload was launched from Pad A on May 14, 1973). Photo credit: NASA

SKYLAB IV - LAUNCH

NASA Image and Video Library

1973-11-27

S73-37286 (16 Nov. 1973) --- The Skylab 4/Saturn 1B space vehicle is launched from Pad B, Launch Complex 39, Kennedy Space Center, Florida, at 9:01:23 a.m. (EST), Friday, Nov. 16, 1973. Skylab 4 is the third and last of three scheduled manned Skylab missions. Aboard the Skylab 4 Command/Service Module were astronauts Gerald P. Carr, Edward G. Gibson and William R. Pogue. In addition to the CSM and its launch escape system, the Skylab 4 space vehicle consisted of the Saturn 1B first (S-1B) stage and the Saturn 1B second (S-IVB) stage. (The Skylab 1/Saturn V unmanned space vehicle with the space station payload was launched from Pad A on May 14, 1973). Photo credit: NASA

Assessment of density functional methods for the study of olefin metathesis catalysed by ruthenium alkylidene complexes

NASA Astrophysics Data System (ADS)

Śliwa, Paweł; Handzlik, Jarosław

2010-06-01

Performance of 31 DFT methods in thermochemistry of olefin metathesis involving the model catalyst (PH 3) 2(Cl) 2Ru dbnd CH 2 is studied using the CCSD(T) reference energies. The best methods are M06, ωB97X-D and PBE0, followed by MPW1B95, LC-ωPBE, M05-2X and B1B95. Among 20 functionals tested in reproduction of experimental PCy 3 dissociation energy for the Grubbs catalyst (H 2IMes)(PCy 3)(Cl) 2Ru dbnd CHPh, the M06-class and M05-2X methods are most accurate. ωB97X-D overestimates the dissociation energy, whereas MPW1B95, LC-ωPBE, PBE0 and B1B95 underestimate it, similarly to other methods, which give larger errors. LC-ωPBE, B1B95, MPW1B95 and PBE0 provide the best geometries.

The preS deletion of hepatitis B virus (HBV) is associated with liver fibrosis progression in patients with chronic HBV infection.

PubMed

Li, Fan; Li, Xiaodong; Yan, Tao; Liu, Yan; Cheng, Yongqian; Xu, Zhihui; Shao, Qing; Liao, Hao; Huang, Pengyu; Li, Jin; Chen, Guo-Feng; Xu, Dongping

2018-03-01

Limited data are available regarding the association of hepatitis B virus (HBV) mutations with liver fibrosis in HBV infection. The study aimed to clarify whether HBV preS deletion mutation is associated with liver fibrosis progression. A total of 469 patients were enrolled, including 324 with chronic hepatitis B (CHB), 28 with HBV-related compensated liver cirrhosis (LC), and 117 with HBV-related decompensated LC. All CHB and compensated LC patients received liver biopsy. Fibrosis grade was assessed using METAVIR score. HBV preS deletion was determined by direct sequencing and verified by clonal sequencing. Overall preS deletion was detected in 12.6% (59/469) patients, specifically, in 7.51% (13/173), 10.60% (16/151), and 20.69% (30/145) of patients with no-to-mild liver fibrosis (F0-1), moderate-to-severe liver fibrosis (F2-3), and cirrhosis (F4), respectively (p < 0.01). Patients with preS-deleted HBV had lower serum HBV DNA and albumin levels compared to patients with wild-type HBV. The median length of preS deletion was 39-base pairs (bp) (3-204 bp) and the deletion most frequently emerged in preS2 initial region. Multivariate analysis identified the preS2 deletion rather than preS1 deletion to be an independent risk factor of significant fibrosis, i.e., METAVIR F ≥ 2 (p = 0.007). In addition, preS-deleted viral sequences were detected in the pool of intrahepatic HBV covalently closed circular DNA. HBV preS deletion is positively associated with liver fibrosis progression in chronic HBV-infected patients. HBV preS2 deletion may serve as a warning indicator for liver fibrosis progression.

14 CFR 33.39 - Lubrication system.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Lubrication system. 33.39 Section 33.39... system. (a) The lubrication system of the engine must be designed and constructed so that it will... supply is in the engine. (b) The lubrication system of the engine must be designed and constructed to...

39 CFR 3001.5 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 39 Postal Service 1 2014-07-01 2014-07-01 false Definitions. 3001.5 Section 3001.5 Postal Service... § 3001.5 Definitions. Link to an amendment published at 79 FR 33406, June 10, 2014. (a) Act means title 39, United States Code, as amended. (b) Postal Service means the U.S. Postal Service established by...

78 FR 18314 - Foreign-Trade Zone (FTZ) 39-Dallas-Fort Worth, Texas; Notification of Proposed Production...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-26

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-25-2013] Foreign-Trade Zone (FTZ) 39--Dallas-Fort Worth, Texas; Notification of Proposed Production Activity; CSI Calendering, Inc. (Rubber Coated Textile Fabric); Arlington, Texas The Dallas/Fort Worth International Airport Board, grantee of FTZ 39...

78 FR 41911 - Foreign-Trade Zone 39-Dallas-Fort Worth, Texas; CSI Calendering, Inc. (Rubber Coated Textile...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-12

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-25-2013] Foreign-Trade Zone 39--Dallas-Fort Worth, Texas; CSI Calendering, Inc. (Rubber Coated Textile Fabric); Arlington, Texas On March 4, 2013, the Dallas/Fort Worth International Airport Board, grantee of FTZ 39, submitted a notification of...

25 CFR 39.105 - Are additional funds available for special education?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Are additional funds available for special education? 39... additional funds available for special education? (a) Schools may supplement the 15 percent base academic funding reserved under § 39.104 for special education with funds available under part B of the Individuals...

KSC00pp1301

NASA Image and Video Library

2000-09-12

KENNEDY SPACE CENTER, Fla. -- This aerial photo captures Launch Pads 39B (left) and 39A (right). Space Shuttle Discovery waits on pad 39A for launch on mission STS-92 Oct. 5, 2000. The ball-shaped structures at left of the pads are storage tanks of the cryogenic liquid propellants for the orbiter’s main engines

KSC-00pp1301

NASA Image and Video Library

2000-09-12

KENNEDY SPACE CENTER, Fla. -- This aerial photo captures Launch Pads 39B (left) and 39A (right). Space Shuttle Discovery waits on pad 39A for launch on mission STS-92 Oct. 5, 2000. The ball-shaped structures at left of the pads are storage tanks of the cryogenic liquid propellants for the orbiter’s main engines

39 CFR 3020.52 - Supporting justification.

Code of Federal Regulations, 2010 CFR

2010-07-01

...(b), taking into account the factors of 39 U.S.C. 3622(c); (c) Explain why, as to competitive... 39 U.S.C. 3633. (d) Verify that the change does not classify as competitive a product over which the Postal Service exercises sufficient market power that it can, without risk of losing a significant level...

25 CFR 39.500 - What emergency and contingency funds are available?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false What emergency and contingency funds are available? 39... SCHOOL EQUALIZATION PROGRAM Contingency Fund § 39.500 What emergency and contingency funds are available... unforeseen contingencies affecting educational programs; (b) Can carry over to the next fiscal year a maximum...

The effect of cellular isolation and cryopreservation on the expression of markers identifying subsets of regulatory T cells.

PubMed

Zhang, Weiying; Nilles, Tricia L; Johnson, Jacquett R; Margolick, Joseph B

2016-04-01

The role of CD4(+) regulatory T cells (Tregs) and their subsets during HIV infection is controversial. Cryopreserved peripheral blood mononuclear cells (PBMC) are an important source for assessing number and function of Tregs. However, it is unknown if PBMC isolation and cryopreservation affect the expression of CD120b and CD39, markers that identify specific subsets of Tregs. HIV-uninfected (HIV-) and -infected (HIV+) men were randomly selected from the Multicenter AIDS Cohort Study (MACS). Percentages of CD120b(+) and CD39(+) Tregs measured by flow cytometry in whole blood and in corresponding fresh and cryopreserved PBMC were compared. Percentages of CD120b(+) Tregs were significantly lower in a) fresh PBMC relative to whole blood, and b) freshly thawed frozen PBMC relative to fresh PBMC when the recovery of viable cryopreserved cells was low. When present, low expression of CD120b in frozen PBMC was reversible by 4h of in vitro culture. In contrast, expression of CD39 on Tregs was not affected by isolation and/or cryopreservation of PBMC, or by relative recovery of cryopreserved PBMC. These findings were unaffected by the HIV status of the donor. The data suggest that percentages of CD120b(+) Tregs and CD39(+) Tregs can be validly measured in either whole blood or PBMC (fresh and frozen) in HIV- and HIV+ men. However, for measurement of CD120b(+) Tregs one type of sample should be used consistently within a given study, and thawed frozen cells may require in vitro culture if recovery of viable cells is low. Copyright © 2016 Elsevier B.V. All rights reserved.

34 CFR 222.40 - How does a local educational agency select a local contribution rate based on generally...

Code of Federal Regulations, 2014 CFR

2014-07-01

... LEAs exclusive of significantly impacted LEAs described in § 222.39(b)(1)) that matches the factor or... these factors, if it were not excluded as significantly impacted in § 222.39(b)(1). Example. An LEA..., size, location, or a combination of these factors, (that is, in the case of the significantly impacted...

34 CFR 222.40 - How does a local educational agency select a local contribution rate based on generally...

Code of Federal Regulations, 2012 CFR

2012-07-01

... LEAs exclusive of significantly impacted LEAs described in § 222.39(b)(1)) that matches the factor or... these factors, if it were not excluded as significantly impacted in § 222.39(b)(1). Example. An LEA..., size, location, or a combination of these factors, (that is, in the case of the significantly impacted...

34 CFR 222.40 - How does a local educational agency select a local contribution rate based on generally...

Code of Federal Regulations, 2011 CFR

2011-07-01

... LEAs exclusive of significantly impacted LEAs described in § 222.39(b)(1)) that matches the factor or... these factors, if it were not excluded as significantly impacted in § 222.39(b)(1). Example. An LEA..., size, location, or a combination of these factors, (that is, in the case of the significantly impacted...

34 CFR 222.40 - How does a local educational agency select a local contribution rate based on generally...

Code of Federal Regulations, 2013 CFR

2013-07-01

... LEAs exclusive of significantly impacted LEAs described in § 222.39(b)(1)) that matches the factor or... these factors, if it were not excluded as significantly impacted in § 222.39(b)(1). Example. An LEA..., size, location, or a combination of these factors, (that is, in the case of the significantly impacted...

KENNEDY SPACE CENTER, FLA. - STS-81 Mission Specialist Jeff Wisoff prepares to enter the Space Shuttle Atlantis at Launch Pad 39B with help from White Room closeout crew members Danny Wyatt (center) and Al Rochford.

NASA Image and Video Library

1997-01-12

KENNEDY SPACE CENTER, FLA. - STS-81 Mission Specialist Jeff Wisoff prepares to enter the Space Shuttle Atlantis at Launch Pad 39B with help from White Room closeout crew members Danny Wyatt (center) and Al Rochford.

KSC-2010-5649

NASA Image and Video Library

2010-11-11

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, Launch Pad 39B is seen from Launch Pad 39A. Pad B is morphing to support a commercial space program with multiple customers, multiple providers and multiple systems that will take Americans to the International Space Station and other low Earth orbit destinations. For information on NASA's future plans, visit www.nasa.gov. Photo credit: NASA/Jack Pfaller

Strength anomaly in B2 FeAl single crystals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoshimi, K.; Hanada, S.; Yoo, M.H.

1994-12-31

Strength and deformation microstructure of B2 Fe-39 and 48%Al single crystals (composition given in atomic percent), which were fully annealed to remove frozen-in vacancies, have been investigated at temperatures between room temperature and 1073K. The hardness of as-homogenized Fe-48Al is higher than that of as-homogenized Fe-39Al while after additional annealing at 698K the hardness of Fe-48Al becomes lower than that of Fe-39Al. Fe-39Al single crystals slowly cooled after homogenizing at a high temperature were deformed in compression as a function of temperature and crystal orientation. A peak of yield strength appears around 0.5T{sub m} (T{sub m} = melting temperature). Themore » orientation dependence of the critical resolved shear stress does not obey Schmid`s law even at room temperature and is quite different from that of b.c.c. metals and B2 intermetallics at low temperatures. At the peak temperature slip transition from <111>-type to <001>-type is found to occur macroscopically and microscopically, while it is observed in TEM that some of the [111] dislocations decompose into [101] and [010] on the (1096I) plane below the peak temperature. The physical sources for the positive temperature dependence of yield stress of B2 FeAl are discussed based on the obtained results.« less

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.

PubMed

Sellier, Chantal; Campanari, Maria-Letizia; Julie Corbier, Camille; Gaucherot, Angeline; Kolb-Cheynel, Isabelle; Oulad-Abdelghani, Mustapha; Ruffenach, Frank; Page, Adeline; Ciura, Sorana; Kabashi, Edor; Charlet-Berguerand, Nicolas

2016-06-15

An intronic expansion of GGGGCC repeats within the C9ORF72 gene is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD). Ataxin-2 with intermediate length of polyglutamine expansions (Ataxin-2 Q30x) is a genetic modifier of the disease. Here, we found that C9ORF72 forms a complex with the WDR41 and SMCR8 proteins to act as a GDP/GTP exchange factor for RAB8a and RAB39b and to thereby control autophagic flux. Depletion of C9orf72 in neurons partly impairs autophagy and leads to accumulation of aggregates of TDP-43 and P62 proteins, which are histopathological hallmarks of ALS-FTD SMCR8 is phosphorylated by TBK1 and depletion of TBK1 can be rescued by phosphomimetic mutants of SMCR8 or by constitutively active RAB39b, suggesting that TBK1, SMCR8, C9ORF72, and RAB39b belong to a common pathway regulating autophagy. While depletion of C9ORF72 only has a partial deleterious effect on neuron survival, it synergizes with Ataxin-2 Q30x toxicity to induce motor neuron dysfunction and neuronal cell death. These results indicate that partial loss of function of C9ORF72 is not deleterious by itself but synergizes with Ataxin-2 toxicity, suggesting a double-hit pathological mechanism in ALS-FTD. © 2016 The Authors.

Canadian Snowbirds fly over KSC

NASA Image and Video Library

2018-05-09

The Canadian Forces Snowbirds fly in Concorde formation over Launch Complex 39B and the Space Coast shoreline at NASA’s Kennedy Space Center in Florida. The Snowbirds, Canada’s air demonstration team, carried out a practice flight over Kennedy and nearby Cape Canaveral Air Force Station in Florida on Wednesday, May 9, 2018, between their scheduled U.S. air shows.

STS-91: Flight Crew Meets with Family and Friends at Launch Complex 39A

NASA Technical Reports Server (NTRS)

1998-01-01

The crew (Commander Charles J. Precourt, Pilot Dominic L. Pudwill Gorie, Mission Specialists Wendy B. Lawrence, Franklin R. Chang-Diaz, Janet L. Kavandi and Valery Victorovitch Ryumin) take time from their busy schedule to chat with friends and family, at a distance. They also pose for group and single pictures.

Portrait - Apollo 10 - MSC

NASA Image and Video Library

1969-05-15

S69-34385 (13 May 1969) --- These three astronauts are the prime crew of the Apollo 10 lunar orbit mission. Left to right, are Eugene A. Cernan, lunar module pilot; John W. Young, command module pilot; and Thomas P. Stafford, commander. In the background is the Apollo 10 space vehicle on Pad B, Launch Complex 39, Kennedy Space Center, Florida.

HATS-39b, HATS-40b, HATS-41b, and HATS-42b: three inflated hot Jupiters and a super-Jupiter transiting F stars

NASA Astrophysics Data System (ADS)

Bento, J.; Hartman, J. D.; Bakos, G. Á.; Bhatti, W.; Csubry, Z.; Penev, K.; Bayliss, D.; de Val-Borro, M.; Zhou, G.; Brahm, R.; Espinoza, N.; Rabus, M.; Jordán, A.; Suc, V.; Ciceri, S.; Sarkis, P.; Henning, T.; Mancini, L.; Tinney, C. G.; Wright, D. J.; Durkan, S.; Tan, T. G.; Lázár, J.; Papp, I.; Sári, P.

2018-07-01

We report the discovery of four transiting hot Jupiters from the HATSouth survey: HATS-39b, HATS-40b, HATS-41b, and HATS-42b. These discoveries add to the growing number of transiting planets orbiting moderately bright (12.5 ≲ V ≲ 13.7) F dwarf stars on short (2-5 d) periods. The planets have similar radii, ranging from 1.33^{+0.29}_{-0.20} RJ for HATS-41b to 1.58^{+0.16}_{-0.12} RJ for HATS-40b. Their masses and bulk densities, however, span more than an order of magnitude. HATS-39b has a mass of 0.63 ± 0.13 MJ, and an inflated radius of 1.57 ± 0.12 RJ, making it a good target for future transmission spectroscopic studies. HATS-41b is a very massive 9.7 ± 1.6 MJ planet and one of only a few hot Jupiters found to date with a mass over 5 MJ. This planet orbits the highest metallicity star ([Fe/H] = 0.470 ± 0.010) known to host a transiting planet and is also likely on an eccentric orbit. The high mass, coupled with a relatively young age (1.34^{+0.31}_{-0.51} Gyr) for the host star, is a factor that may explain why this planet's orbit has not yet circularized.

Mutations in the Small GTPase Gene RAB39B Are Responsible for X-linked Mental Retardation Associated with Autism, Epilepsy, and Macrocephaly

PubMed Central

Giannandrea, Maila; Bianchi, Veronica; Mignogna, Maria Lidia; Sirri, Alessandra; Carrabino, Salvatore; D'Elia, Errico; Vecellio, Matteo; Russo, Silvia; Cogliati, Francesca; Larizza, Lidia; Ropers, Hans-Hilger; Tzschach, Andreas; Kalscheuer, Vera; Oehl-Jaschkowitz, Barbara; Skinner, Cindy; Schwartz, Charles E.; Gecz, Jozef; Van Esch, Hilde; Raynaud, Martine; Chelly, Jamel; de Brouwer, Arjan P.M.; Toniolo, Daniela; D'Adamo, Patrizia

2010-01-01

Human Mental Retardation (MR) is a common and highly heterogeneous pediatric disorder affecting around 3% of the general population; at least 215 X-linked MR (XLMR) conditions have been described, and mutations have been identified in 83 different genes, encoding proteins with a variety of function, such as chromatin remodeling, synaptic function, and intracellular trafficking. The small GTPases of the RAB family, which play an essential role in intracellular vesicular trafficking, have been shown to be involved in MR. We report here the identification of mutations in the small GTPase RAB39B gene in two male patients. One mutation in family X (D-23) introduced a stop codon seven amino acids after the start codon (c.21C > A; p.Y7X). A second mutation, in the MRX72 family, altered the 5′ splice site (c.215+1G > A) and normal splicing. Neither instance produced a protein. Mutations segregate with the disease in the families, and in some family members intellectual disabilities were associated with autism spectrum disorder, epileptic seizures, and macrocephaly. We show that RAB39B, a novel RAB GTPase of unknown function, is a neuronal-specific protein that is localized to the Golgi compartment. Its downregulation leads to an alteration in the number and morphology of neurite growth cones and a significant reduction in presynaptic buttons, suggesting that RAB39B is required for synapse formation and maintenance. Our results demonstrate developmental and functional neuronal alteration as a consequence of downregulation of RAB39B and emphasize the critical role of vesicular trafficking in the development of neurons and human intellectual abilities. PMID:20159109

KSC-04pd0660

NASA Image and Video Library

2004-03-26

CAPE CANAVERAL, Fla. -- This aerial photo shows the expanse of the Launch Complex 39 Area, bordered on the east by the Atlantic Ocean and cloud-filled sky. At center right, towering above the surrounding sites, is the Vehicle Assembly Building. To the left, or north, is the Orbiter Processing Facility’s Bay 3. On the western side are OPF Bays 1 and 2. South, near the roadway, is the Operations Support Building. The two-lane crawlerway stretches from the VAB toward the coast, site of Launch Pad 39A, closest, and Launch Pad 39B, far left. Between the VAB and the ocean sprawl the Banana Creek and the Banana River. The turn basin, at right, allows delivery of external tanks that are offloaded close to and transported to the VAB. At the western end of the Turn Basin sits the press mound, home of the NASA KSC News Center. Photo credit: NASA

CD39 improves survival in microbial sepsis by attenuating systemic inflammation

PubMed Central

Csóka, Balázs; Németh, Zoltán H.; Törő, Gábor; Koscsó, Balázs; Kókai, Endre; Robson, Simon C.; Enjyoji, Keiichi; Rolandelli, Rolando H.; Erdélyi, Katalin; Pacher, Pál; Haskó, György

2015-01-01

Sepsis remains the leading cause of morbidity and mortality in critically ill patients. Excessive inflammation is a major cause of organ failure and mortality in sepsis. Ectonucleoside triphosphate diphosphohydrolase 1, ENTPDase1 (CD39) is a cell surface nucleotide-metabolizing enzyme, which degrades the extracellular purines ATP and ADP, thereby regulating purinergic receptor signaling. Although the role of purinergic receptor signaling in regulating inflammation and sepsis has been addressed previously, the role of CD39 in regulating the host’s response to sepsis is unknown. We found that the CD39 mimic apyrase (250 U/kg) decreased and knockout or pharmacologic blockade with sodium polyoxotungstate (5 mg/kg; IC50 ≈ 10 μM) of CD39 increased mortality of mice with polymicrobial sepsis induced by cecal ligation and puncture. CD39 decreased inflammation, organ damage, immune cell apoptosis, and bacterial load. Use of bone marrow chimeric mice revealed that CD39 expression on myeloid cells decreases inflammation in septic mice. CD39 expression is upregulated during sepsis in mice, as well as in both murine and human macrophages stimulated with Escherichia coli. Moreover, E. coli increases CD39 promoter activity in macrophages. Altogether, these data indicate CD39 as an evolutionarily conserved inducible protective pathway during sepsis. We propose CD39 as a novel therapeutic target in the management of sepsis.—Csóka, B., Németh, Z. H., Törő, G., Koscsó, B., Kókai, E., Robson, S. C., Enjyoji, K., Rolandelli, R. H., Erdélyi, K., Pacher, P., Haskó, G. CD39 improves survival in microbial sepsis by attenuating systemic inflammation. PMID:25318479

Epidemiology of Tick-Borne Borreliosis in Morocco

PubMed Central

Diatta, Georges; Souidi, Yassine; Granjon, Laurent; Arnathau, Céline; Durand, Patrick; Chauvancy, Gilles; Mané, Youssouph; Sarih, M'hammed; Belghyti, Driss; Renaud, François; Trape, Jean-François

2012-01-01

Background The presence in Morocco of Argasid ticks of the Ornithodoros erraticus complex, the vector of tick-borne relapsing fever (TBRF) in North Africa, has been known since 1919, but the disease is rarely diagnosed and few epidemiological data are available. Methodology/Principal Findings Between 2006 and 2011, we investigated the presence of Ornithodoros ticks in rodent burrows in 34 sites distributed across Morocco. We also collected small mammals in 10 sites and we investigated TBRF in febrile patients in Kenitra district. The prevalence of Borrelia infections was assessed by nested PCR amplification in ticks and the brain tissue of small mammals, and by evaluation of thick blood films in patients. A high proportion of burrows were infested with ticks of the O. erraticus complex in all regions of Morocco, with a mean of 39.5% for the whole country. Borrelia infections were found in 39/382 (10.2%) of the ticks and 12/140 (8.6%) of the rodents and insectivores studied by PCR amplification, and 102 patients tested positive by thick blood film. Five small mammalian species were found infected: Dipodillus campestris, Meriones shawi, Gerbillus hoogstrali, Gerbillus occiduus and Atelerix algirus. Three Borrelia species were identified in ticks and/or rodents: B. hispanica, B. crocidurae and B. merionesi. Conclusions/Significance Tick populations belonging to O. erraticus complex are widely distributed in Morocco and a high proportion of ticks and small mammals are infected by Borrelia species. Although rarely diagnosed, TBRF may be a common cause of morbidity in all regions of Morocco. PMID:23029574

Identification of a Linked Set of Genes in Serpulina hyodysenteriae (B204) Predicted To Encode Closely Related 39-Kilodalton Extracytoplasmic Proteins

PubMed Central

Gabe, Jeffrey D.; Dragon, Elizabeth; Chang, Ray-Jen; McCaman, Michael T.

1998-01-01

A tandem pair of nearly identical genes from Serpulina hyodysenteriae (B204) were cloned and sequenced. The full open reading frame of one gene and the partial open reading frame of the neighboring gene appear to encode secreted proteins which are homologous to, yet distinct from, the 39-kDa extracytoplasmic protein purified from the membrane fraction of S. hyodysenteriae. We have designated these newly identified genes vspA and vspB (for variable surface protein). PMID:9440540

Electron Paramagnetic Resonance Spectroscopy of Vanadium (IV) Complexes and Related Species.

DTIC Science & Technology

1980-07-27

Extensive near infrared (4000-650cm " ) investigations on VOCl 2 complexes have been made by many workers [21,39,43-49]. However the far infrared ...to facilitate the assignment of cation and ligand bacds. 4.2.1.2 Near Infrared Spectroscopy There are three principal reasons for measuriiio the... near infrared spectra of the co!;,plexes: (a) To establish the purity of the complex (b) To establish the bondi ng mode of the 1 i ( nd (c) To establish

25 CFR 39.411 - How will the auditor report its findings?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false How will the auditor report its findings? 39.411 Section... EQUALIZATION PROGRAM Accountability § 39.411 How will the auditor report its findings? (a) The auditor selected... to the findings, where submitted, in the final audit report. (b) The auditor must submit a final...

49 CFR 39.5 - To whom do the provisions of this part apply?

Code of Federal Regulations, 2010 CFR

2010-10-01

... affect commerce and that provides specified public transportation; (b) If you are the PVO of a foreign... 49 Transportation 1 2010-10-01 2010-10-01 false To whom do the provisions of this part apply? 39.5 Section 39.5 Transportation Office of the Secretary of Transportation TRANSPORTATION FOR INDIVIDUALS WITH...

9 CFR 201.39 - Payment to be made to consignor or shipper by market agencies; exceptions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... shipper by market agencies; exceptions. 201.39 Section 201.39 Animals and Animal Products GRAIN INSPECTION... shipper by market agencies; exceptions. (a) No market agency shall, except as provided in paragraph (b) of... from the Secretary or a court of competent jurisdiction, unless (1) such market agency has reason to...

10 CFR 1.39 - Office of the Chief Human Capital Officer.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 1 2014-01-01 2014-01-01 false Office of the Chief Human Capital Officer. 1.39 Section 1... Headquarters Staff Offices § 1.39 Office of the Chief Human Capital Officer. The Office of the Chief Human... effective organization, utilization, and development of the agency's human resources; (b) Provides labor...

25 CFR 39.411 - How will the auditor report its findings?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false How will the auditor report its findings? 39.411 Section... EQUALIZATION PROGRAM Accountability § 39.411 How will the auditor report its findings? (a) The auditor selected... to the findings, where submitted, in the final audit report. (b) The auditor must submit a final...

7 CFR 1230.39 - Powers and duties of the Delegate Body.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 10 2011-01-01 2011-01-01 false Powers and duties of the Delegate Body. 1230.39... Order National Pork Producers Delegate Body § 1230.39 Powers and duties of the Delegate Body. The Delegate Body shall have the following powers and duties: (a) To meet annually; (b) To recommend the rate...

34 CFR 222.39 - How does a State educational agency identify generally comparable local educational agencies for...

Code of Federal Regulations, 2010 CFR

2010-07-01

..., DEPARTMENT OF EDUCATION IMPACT AID PROGRAMS Payments for Federally Connected Children Under Section 8003(b... 34 Education 1 2010-07-01 2010-07-01 false How does a State educational agency identify generally comparable local educational agencies for local contribution rate purposes? 222.39 Section 222.39 Education...

34 CFR Appendix E to Part 300 - Index for IDEA-Part B Regulations (34 CFR Part 300)

Code of Federal Regulations, 2013 CFR

2013-07-01

....152(c)(3). COMPLAINT(S): STATE COMPLAINT PROCEDURES (Q-Z) • See also §§ 300.151 through 300.153 • Time...). • Scientifically based research 300.35. • Secondary school 300.36. • Secretary 300.38. • Serious bodily injury 300... education 300.39(a). • Specially designed instruction 300.39(b)(3). • Specific learning disability 300.8(c...

34 CFR Appendix E to Part 300 - Index for IDEA-Part B Regulations (34 CFR Part 300)

Code of Federal Regulations, 2014 CFR

2014-07-01

....152(c)(3). COMPLAINT(S): STATE COMPLAINT PROCEDURES (Q-Z) • See also §§ 300.151 through 300.153 • Time...). • Scientifically based research 300.35. • Secondary school 300.36. • Secretary 300.38. • Serious bodily injury 300... education 300.39(a). • Specially designed instruction 300.39(b)(3). • Specific learning disability 300.8(c...

34 CFR Appendix E to Part 300 - Index for IDEA-Part B Regulations (34 CFR Part 300)

Code of Federal Regulations, 2012 CFR

2012-07-01

....152(c)(3). COMPLAINT(S): STATE COMPLAINT PROCEDURES (Q-Z) • See also §§ 300.151 through 300.153 • Time...). • Scientifically based research 300.35. • Secondary school 300.36. • Secretary 300.38. • Serious bodily injury 300... education 300.39(a). • Specially designed instruction 300.39(b)(3). • Specific learning disability 300.8(c...

KSC-2010-5660

NASA Image and Video Library

2010-11-12

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, two rainbows appear between Launch Pad 39B and Launch Pad 39A. Pad B, seen here, is morphing to support a commercial space program with multiple customers, multiple providers and multiple systems that will take Americans to the International Space Station and other low Earth orbit destinations. For information on NASA's future plans, visit www.nasa.gov. Photo credit: NASA/Troy Cryder

Arabidopsis TAF15b Localizes to RNA Processing Bodies and Contributes to snc1-Mediated Autoimmunity.

PubMed

Dong, Oliver X; Meteignier, Louis-Valentin; Plourde, Melodie B; Ahmed, Bulbul; Wang, Ming; Jensen, Cassandra; Jin, Hailing; Moffett, Peter; Li, Xin; Germain, Hugo

2016-04-01

In both animals and plants, messenger (m)RNA export has been shown to contribute to immune response regulation. The Arabidopsis nuclear protein MOS11, along with the nucleoporins MOS3/Nup96/SAR3 and Nup160/SAR1 are components of the mRNA export machinery and contribute to immunity mediated by nucleotide binding leucine-rich repeat immune receptors (NLR). The human MOS11 ortholog CIP29 is part of a small protein complex with three additional members: the RNA helicase DDX39, ALY, and TAF15b. We systematically assessed the biological roles of the Arabidopsis homologs of these proteins in toll interleukin 1 receptor-type NLR (TNL)-mediated immunity using reverse genetics. Although mutations in ALY and DDX39 did not result in obvious defects, taf15b mutation partially suppressed the autoimmune phenotypes of a gain-of-function TNL mutant, snc1. An additive effect on snc1 suppression was observed in mos11-1 taf15b snc1 triple mutant plants, suggesting that MOS11 and TAF15b have independent functions. TAF15b-GFP fusion protein, which fully complemented taf15b mutant phenotypes, localized to nuclei similarly to MOS11. However, it was also targeted to cytosolic granules identified as processing bodies. In addition, we observed no change in SNC1 mRNA levels, whereas less SNC1 protein accumulated in taf15b mutant, suggesting that TAF15b contributes to SNC1 homeostasis through posttranscriptional mechanisms. In summary, this study highlights the importance of posttranscriptional RNA processing mediated by TAF15b in the regulation of TNL-mediated immunity.

25. Photocopy of engineering drawing. LC17B LONG TANK DELTA UPBUILD: ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

25. Photocopy of engineering drawing. LC-17B LONG TANK DELTA UPBUILD: MOBILE SERVICE TOWER, WEATHER CURTAINS SECTION 1 AND PLANS LEVELS 4 & 4A, 3, 2X, & 1A-ARCHITECTURAL, APRIL 1969. - Cape Canaveral Air Station, Launch Complex 17, Facility 28417, East end of Lighthouse Road, Cape Canaveral, Brevard County, FL

View of Apollo 15 space vehicle leaving VAB to Pad A, Launch Complex 39

NASA Image and Video Library

1971-05-11

S71-33786 (11 May 1971) --- The 363-feet tall Apollo (Spacecraft 112/Lunar Module 10/Saturn 510) space vehicle which leaves the Vehicle Assembly Building (VAB) to Pad A, Launch Complex 39, Kennedy Space Center (KSC). The Saturn V stack and its mobile launch tower are atop a huge crawler-transporter. Apollo 15 is scheduled as the fourth manned lunar landing mission by the National Aeronautics and Space Administration (NASA) and is scheduled to lift off on July 26, 1971. The crew men will be astronauts David R. Scott, commander; Alfred M. Worden, command module pilot; and James B. Irwin, lunar module pilot. While astronaut Scott and Irwin will descend in the Lunar Module (LM) to explore the moon, astronaut Worden will remain with the Command and Service Modules (CSM) in lunar orbit.

KSC-04pd2138

NASA Image and Video Library

2004-10-15

KENNEDY SPACE CENTER, FLA. - A closeup of some of the new crawler shoes that arrived from Minnesota. The new shoes were manufactured by ME Global in Duluth. The CT transports the Mobile Launcher Platform, with the assembled Space Shuttle aboard, between the refurbishment area, the VAB and Launch Complex Pads 39A and 39B. The crawlers have 456 shoes, 57 per belt (8 belts in all). Each shoe weighs 2,200 pounds. The original shoes were manufactured for the Apollo Program. Cracks appeared in the shoes in recent years spurring a need for replacement. The new manufacturer, in Duluth, Minn., has improved the design for Return to Flight and use through the balance of the Space Shuttle Program.

KSC-99pp0432

NASA Image and Video Library

1999-04-23

KENNEDY SPACE CENTER, Fla. -- Reflected in the turn basin at Launch Complex 39 Area, the Space Shuttle Discovery stands atop the crawler-transporter, which carries its cargo at 1 mph to Launch Pad 39B. The vehicle takes about five hours to cover the journey from the Vehicle Assembly Building to the launch pad. Liftoff of Discovery on mission STS-96 is targeted for May 20 at 9:32 a.m. EDT. STS-96 is a logistics and resupply mission for the International Space Station, carrying such payloads as a Russian crane, the Strela; a U.S.-built crane; the Spacehab Oceaneering Space System Box (SHOSS), a logistics items carrier; and STARSHINE, a student-led experiment

The STS-90 crew wave to family and friends in front of Launch Pad 39B

NASA Technical Reports Server (NTRS)

1998-01-01

The STS-90 crew wave to friends and family members near Launch Pad 39B, from which they are scheduled to launch aboard Columbia on May 16 at 2:19 p.m. EDT. The crew include, left to right, Mission Specialist Richard Linnehan, D.V.M., Commander Richard Searfoss, Pilot Scott Altman, Payload Specialists James Pawelczyk, Ph.D., and Jay Buckey, M.D., and Mission Specialists Dafydd (Dave) Williams, M.D., with the Canadian Space Agency, and Kathryn (Kay) Hire. The Space Shuttle Columbia is seen in the background, protected by its Rotating Service Structure. This is the 25th flight of Columbia and the 90th mission flown since the start of the Space Shuttle program. STS-90 is a nearly 17-day life sciences research flight that will focus on the most complex and least understood part of the human body -- the nervous system. Neurolab will examine the effects of spaceflight on the brain, spinal cord, peripheral nerves and sensory organs in the human body.

39 CFR 320.5 - Suspension for certain international-ocean carrier-related documents.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 39 Postal Service 1 2013-07-01 2013-07-01 false Suspension for certain international-ocean carrier...-ocean carrier-related documents. The operation of 39 U.S.C. 601(a) (1) through (6) and § 310.2(b) (1) through (6) of this chapter is suspended on all post routes for documents, sent by a shipper or an ocean...

39 CFR 320.5 - Suspension for certain international-ocean carrier-related documents.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 39 Postal Service 1 2014-07-01 2014-07-01 false Suspension for certain international-ocean carrier...-ocean carrier-related documents. The operation of 39 U.S.C. 601(a) (1) through (6) and § 310.2(b) (1) through (6) of this chapter is suspended on all post routes for documents, sent by a shipper or an ocean...

39 CFR 320.5 - Suspension for certain international-ocean carrier-related documents.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Suspension for certain international-ocean carrier...-ocean carrier-related documents. The operation of 39 U.S.C. 601(a) (1) through (6) and § 310.2(b) (1) through (6) of this chapter is suspended on all post routes for documents, sent by a shipper or an ocean...

39 CFR 320.5 - Suspension for certain international-ocean carrier-related documents.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 39 Postal Service 1 2011-07-01 2011-07-01 false Suspension for certain international-ocean carrier...-ocean carrier-related documents. The operation of 39 U.S.C. 601(a) (1) through (6) and § 310.2(b) (1) through (6) of this chapter is suspended on all post routes for documents, sent by a shipper or an ocean...

39 CFR 320.5 - Suspension for certain international-ocean carrier-related documents.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 39 Postal Service 1 2012-07-01 2012-07-01 false Suspension for certain international-ocean carrier...-ocean carrier-related documents. The operation of 39 U.S.C. 601(a) (1) through (6) and § 310.2(b) (1) through (6) of this chapter is suspended on all post routes for documents, sent by a shipper or an ocean...

25 CFR 39.807 - How will the Student Unit Value be adjusted annually?

Code of Federal Regulations, 2011 CFR

2011-04-01

... Labor. (b) If the student unit value amount is not fully funded, the schools will receive their pro rata... 25 Indians 1 2011-04-01 2011-04-01 false How will the Student Unit Value be adjusted annually? 39.807 Section 39.807 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR EDUCATION THE INDIAN...

KEA-144: Final Results of the Ground Operations Demonstration Unit for Liquid Hydrogen (GODU-LH2) Project

NASA Technical Reports Server (NTRS)

Notardonato, William; Fesmire, James; Swanger, Adam; Jumper, Kevin; Johnson, Wesley; Tomsik, Thomas

2017-01-01

GODU-LH2 system has successfully met all test objectives at the 33%, 67%, and 100% tank fill level. Complete control over the state of the fluid has been demonstrated using Integrated Refrigeration and Storage (IRAS). Almost any desired point along the H2saturation curve can essentially be "dialed in" and maintained indefinitely. System can also be used to produce densified hydrogen in large quantities to the triple point. Exploring multiple technology infusion paths. Studying implementation of IRAS technology into new LH2sphere for EM-2 at LC39B. Technical interchange also occurring with STMD, LSP, ULA, DoE, KIST, Kawasaki, Shell Oil, SpaceX, US Coast Guard, and Virgin Galactic.

49 CFR 173.304a - Additional requirements for shipment of liquefied compressed gases in specification cylinders.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., carbon bisulfide (disulfide), ethyl chloride, ethylene oxide, nickel carbonyl, spirits of nitroglycerin...; DOT-3B400; DOT-4AA480; DOT-4B400; DOT-4BA400; DOT-4BW400; DOT-3E1800; DOT-39; DOT-3AL400. Carbon...; DOT-3T1800; DOT-3HT2000; DOT-39; DOT-3AL1800. Carbon dioxide, refrigerated liquid (see paragraph (e...

49 CFR 173.304a - Additional requirements for shipment of liquefied compressed gases in specification cylinders.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., carbon bisulfide (disulfide), ethyl chloride, ethylene oxide, nickel carbonyl, spirits of nitroglycerin...; DOT-3B400; DOT-4AA480; DOT-4B400; DOT-4BA400; DOT-4BW400; DOT-3E1800; DOT-39; DOT-3AL400. Carbon...; DOT-3T1800; DOT-3HT2000; DOT-39; DOT-3AL1800. Carbon dioxide, refrigerated liquid (see paragraph (e...

KSC-08pd4106

NASA Image and Video Library

2008-12-19

CAPE CANAVERAL, Fla. -- On Launch Pad 39B at NASA's Kennedy Space Center in Florida, one of the new lightning towers is under construction. The towers will hold catenary wires as part of the new lightning protection system for the Constellation Program and Ares/Orion launches. Pad 39B will be the site of the first Ares vehicle launch, including Ares I-X test flight that is targeted for July 2009. Photo credit: NASA/Tim Jacobs

VLT FORS2 COMPARATIVE TRANSMISSION SPECTROSCOPY: DETECTION OF Na IN THE ATMOSPHERE OF WASP-39b FROM THE GROUND

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nikolov, Nikolay; Sing, David K.; Evans, Thomas M.

2016-12-01

We present transmission spectroscopy of the warm Saturn-mass exoplanet WASP-39b made with the Very Large Telescope FOcal Reducer and Spectrograph (FORS2) across the wavelength range 411–810 nm. The transit depth is measured with a typical precision of 240 parts per million (ppm) in wavelength bins of 10 nm on a V  = 12.1 mag star. We detect the sodium absorption feature (3.2 σ ) and find evidence of potassium. The ground-based transmission spectrum is consistent with Hubble Space Telescope ( HST ) optical spectroscopy, supporting the interpretation that WASP-39b has a largely clear atmosphere. Our results demonstrate the great potential of the recently upgraded FORS2 spectrograph formore » optical transmission spectroscopy, with which we obtained HST -quality light curves from the ground.« less

The STS-103 crew address family and friends at Pad 39B

NASA Technical Reports Server (NTRS)

1999-01-01

The STS-103 crew address family and friends at Launch Pad 39B. From left to right are Pilot Scott J. Kelly, Commander Curtis L. Brown Jr., and Mission Specialists C. Michael Foale (Ph.D.), John M. Grunsfeld (Ph.D.), Jean-Frangois Clervoy of France , Claude Nicollier of Switzerland and Steven L. Smith. Nicollier and Clervoy are with the European Space Agency. In the background is Space Shuttle Discovery, alongside the lighted Fixed Service Structure. The STS-103 mission, to service the Hubble Space Telescope, is scheduled for launch Dec. 17 at 8:47 p.m. EST from Launch Pad 39B. Mission objectives include replacing gyroscopes and an old computer, installing another solid state recorder, and replacing damaged insulation in the telescope. The mission is expected to last about 8 days and 21 hours. Discovery is expected to land at KSC Sunday, Dec. 26, at about 6:25 p.m. EST.

Interaural attenuation for Sennheiser HDA 200 circumaural earphones.

PubMed

Brännström, K Jonas; Lantz, Johannes

2010-06-01

Interaural attenuation (IA) was evaluated for pure tones (frequency range 125 to 16000 Hz) using Sennheiser HDA 200 circumaural earphones and Telephonics TDH-39P earphones in nine unilaterally deaf subjects. Audiometry was conducted in 1-dB steps using the manual ascending technique in accordance with ISO 8253-1. For all subjects and for all tested frequencies, the lowest IA value for HDA 200 was 42 dB. The present IA values for TDH-39P earphones closely resemble previously reported data. The findings show that the HDA 200 earphones provide more IA than the TDH-39P, especially at lower frequencies (

Acute toxicity of fire-control chemicals, nitrogenous chemicals, and surfactants to rainbow trout

USGS Publications Warehouse

Buhl, Kevin J.; Hamilton, Steven J.

2000-01-01

Laboratory studies were conducted to determine the acute toxicity of three ammonia-based fire retardants (Fire-Trol LCA-F, Fire-Trol LCM-R, and Phos-Chek 259F), five surfactant-based fire-suppressant foams (FireFoam 103B, FireFoam 104, Fire Quench, ForExpan S, and Pyrocap B-136), three nitrogenous chemicals (ammonia, nitrate, and nitrite), and two anionic surfactants (linear alkylbenzene sulfonate [LAS] and sodium dodecyl sulfate [SDS]) to juvenile rainbow trout Oncorhynchus mykiss in soft water. The descending rank order of toxicity (96-h concentration lethal to 50% of test organisms [96-h LC50]) for the fire retardants was as follows: Phos-Chek 259F (168 mg/L) > Fire-Trol LCA-F (942 mg/L) = Fire-Trol LCM-R (1,141 mg/L). The descending rank order of toxicity for the foams was as follows: FireFoam 103B (12.2 mg/L) = FireFoam 104 (13.0 mg/L) > ForExpan S (21.8 mg/L) > Fire Quench (39.0 mg/L) > Pyrocap B-136 [156 mg/L). Except for Pyrocap B-136, the foams were more toxic than the fire retardants. Un-ionized ammonia (NH3; 0.125 mg/L as N) was about six times more toxic than nitrite (0.79 mg/L NO2-N) and about 13,300 times more toxic than nitrate (1,658 mg/L NO3-N). Linear alkylbenzene sulfonate (5.0 mg/L) was about five times more toxic than SDS (24.9 mg/L). Estimated total ammonia and NH3 concentrations at the 96-h LC50s of the fire retardants indicated that ammonia was the primary toxic component in these formulations. Based on estimated anionic surfactant concentrations at the 96-h LC50s of the foams and reference surfactants, LAS was intermediate in toxicity and SDS was less toxic to rainbow trout when compared with the foams. Comparisons of recommended application concentrations to the test results indicate that accidental inputs of these chemicals into streams require substantial dilutions (100-1,750-fold to reach concentrations nonlethal to rainbow trout.

Properties of Refractory Concrete in Tension and Compression

NASA Technical Reports Server (NTRS)

Sampson, Jeffrey

2009-01-01

Refractory concrete on the LC-39A Flame Deflector has been damaged during multiple Space Shuttle launches (e.g. STS-124, STS-126, STS-119, and STS-125, STS-127). These events have prompted a better understanding of the system via an analytical model of the Flame Deflector assembly to include the Fondu Fyre refractory concrete. This model requires test data inputs of the refractory concrete's mechanical properties, which include stress versus strain curves in tension and compression, modulus of elasticity, and Poisson's ratio. Sections of Fondu Fyre refractory concrete removed from the LC-39A Flame Deflector were provided for this testing.

Characterization of hemizygous deletions in Citrus using array-Comparative Genomic Hybridization and microsynteny comparisons with the poplar genome

PubMed Central

Ríos, Gabino; Naranjo, Miguel A; Iglesias, Domingo J; Ruiz-Rivero, Omar; Geraud, Marion; Usach, Antonio; Talón, Manuel

2008-01-01

Background Many fruit-tree species, including relevant Citrus spp varieties exhibit a reproductive biology that impairs breeding and strongly constrains genetic improvements. In citrus, juvenility increases the generation time while sexual sterility, inbreeding depression and self-incompatibility prevent the production of homozygous cultivars. Genomic technology may provide citrus researchers with a new set of tools to address these various restrictions. In this work, we report a valuable genomics-based protocol for the structural analysis of deletion mutations on an heterozygous background. Results Two independent fast neutron mutants of self-incompatible clementine (Citrus clementina Hort. Ex Tan. cv. Clemenules) were the subject of the study. Both mutants, named 39B3 and 39E7, were expected to carry DNA deletions in hemizygous dosage. Array-based Comparative Genomic Hybridization (array-CGH) using a Citrus cDNA microarray allowed the identification of underrepresented genes in these two mutants. Subsequent comparison of citrus deleted genes with annotated plant genomes, especially poplar, made possible to predict the presence of a large deletion in 39B3 of about 700 kb and at least two deletions of approximately 100 and 500 kb in 39E7. The deletion in 39B3 was further characterized by PCR on available Citrus BACs, which helped us to build a partial physical map of the deletion. Among the deleted genes, ClpC-like gene coding for a putative subunit of a multifunctional chloroplastic protease involved in the regulation of chlorophyll b synthesis was directly related to the mutated phenotype since the mutant showed a reduced chlorophyll a/b ratio in green tissues. Conclusion In this work, we report the use of array-CGH for the successful identification of genes included in a hemizygous deletion induced by fast neutron irradiation on Citrus clementina. The study of gene content and order into the 39B3 deletion also led to the unexpected conclusion that microsynteny and local gene colinearity in this species were higher with Populus trichocarpa than with the phylogenetically closer Arabidopsis thaliana. This work corroborates the potential of Citrus genomic resources to assist mutagenesis-based approaches for functional genetics, structural studies and comparative genomics, and hence to facilitate citrus variety improvement. PMID:18691431

Rock magnetic and paleomagnetic study of the Keurusselkä impact structure, central Finland

NASA Astrophysics Data System (ADS)

Raiskila, Selen; Salminen, Johanna; Elbra, Tiiu; Pesonen, Lauri J.

2011-11-01

There are 31 proven impact structures in Fennoscandia—one of the most densely crater-populated areas of the Earth. The recently discovered Keurusselkä impact structure (62°08' N, 24°37' E) is located within the Central Finland Granitoid Complex, which formed 1890-1860 Ma ago during the Svecofennian orogeny. It is a deeply eroded complex crater that yields in situ shatter cones with evidence of shock metamorphism, e.g., planar deformation features in quartz. New petrophysical and rock magnetic results of shocked and unshocked target rocks of various lithologies combined with paleomagnetic studies are presented. The suggested central uplift with shatter cones is characterized by increased magnetization and susceptibility. The presence of magnetite and pyrrhotite was observed as carriers for the remanent magnetization. Four different remanent magnetization directions were isolated: (1) a characteristic Svecofennian target rock component A with a mean direction of D = 334.8°, I = 45.6°, α95 = 14.9° yielding a pole (Plat = 51.1°, Plon = 241.9°, A95 = 15.1°), (2) component B, D = 42.4°, I = 64.1°, α95 = 8.4° yielding a pole (Plat = 61.0°, Plon = 129.1°, A95 = 10.6°), (3) component C (D = 159.5°, I = 65.4°, α95 = 10.7°) yielding a pole (Plat = 21.0°, Plon = 39.3°, A95 = 15.6°), and (4) component E (D = 275.5°, I = 62.0°, α95 = 14.4°) yielding a pole (Plat = 39.7°, Plon = 314.3°, A95 = 19.7°). Components C and E are considered much younger, possibly Neoproterozoic overprints, compared with the components A and B. The pole of component B corresponds with the 1120 Ma pole of Salla diabase dyke and is in agreement with the 40Ar/39Ar age of 1140 Ma from a pseudotachylitic breccia vein in a central part of the structure. Therefore, component B could be related to the impact, and thus represent the impact age.

48 CFR 39.201 - Scope of subpart.

Code of Federal Regulations, 2014 CFR

2014-10-01

... CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Electronic and Information Technology 39.201 Scope of... the Architectural and Transportation Barriers Compliance Board Electronic and Information Technology (EIT) Accessibility Standards (36 CFR part 1194). (b) Further information on section 508 is available...

48 CFR 39.201 - Scope of subpart.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Electronic and Information Technology 39.201 Scope of... the Architectural and Transportation Barriers Compliance Board Electronic and Information Technology (EIT) Accessibility Standards (36 CFR part 1194). (b) Further information on section 508 is available...

48 CFR 39.201 - Scope of subpart.

Code of Federal Regulations, 2011 CFR

2011-10-01

... CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Electronic and Information Technology 39.201 Scope of... the Architectural and Transportation Barriers Compliance Board Electronic and Information Technology (EIT) Accessibility Standards (36 CFR part 1194). (b) Further information on section 508 is available...

48 CFR 39.201 - Scope of subpart.

Code of Federal Regulations, 2013 CFR

2013-10-01

... CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Electronic and Information Technology 39.201 Scope of... the Architectural and Transportation Barriers Compliance Board Electronic and Information Technology (EIT) Accessibility Standards (36 CFR part 1194). (b) Further information on section 508 is available...

48 CFR 39.201 - Scope of subpart.

Code of Federal Regulations, 2012 CFR

2012-10-01

... CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Electronic and Information Technology 39.201 Scope of... the Architectural and Transportation Barriers Compliance Board Electronic and Information Technology (EIT) Accessibility Standards (36 CFR part 1194). (b) Further information on section 508 is available...

41 CFR 101-39.001 - Authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET... establishing fleet management systems to serve the needs of executive agencies; and (b) provide for the establishment, maintenance, and operation (including servicing and storage) of fleet management systems for...

Publications - PDF 98-39 | Alaska Division of Geological & Geophysical

Science.gov Websites

content DGGS PDF 98-39 Publication Details Title: Rock geochemistry from the Manley mining district ., Bundtzen, T.K., Newberry, R.J., Dover, J.H., and Blodgett, R.B., 1998, Rock geochemistry from the Manley

NAVAIR Hexavalent Chromium Minimization Status

DTIC Science & Technology

2010-11-01

NAVAIR  Hexavalent  Chromium Minimization Status  SERDP/ESTCP Symposium 2010 Cr6+ Session Bill C Nickerson AIR 4.3.4 Report Documentation Page Form...COVERED 00-00-2010 to 00-00-2010 4. TITLE AND SUBTITLE NAVAIR Hexavalent Chromium Minimization Status 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c...ANSI Std Z39-18 Minimizing Hexavalent Chromium Use in DoD Operations Technical Session No. 2B C-39 NAVAIR NON-CHROMATE MATERIALS STATUS MR

Fasting triggers hypothermia, and ambient temperature modulates its depth in Japanese quail Coturnix japonica.

PubMed

Ben-Hamo, Miriam; Pinshow, Berry; McCue, Marshall D; McWilliams, Scott R; Bauchinger, Ulf

2010-05-01

We tested three hypotheses regarding the cues that elicit facultative hypothermia in Japanese quail (Coturnix japonica): H(1)) Ambient temperature (T(a)), alone, influences the onset and depth of hypothermia; H(2)) Fasting, alone, influences the onset and depth of hypothermia; H(3)) T(a) acts synergistically with fasting to shape the use of hypothermia. Eight quail were maintained within their thermoneutral zone (TNZ) at 32.6+/-0.2 degrees C, and eight below their lower critical temperature (T(lc)) at 12.7+/-3.0 degrees C. All quail entered hypothermia upon food deprivation, even quail kept within their TNZ. Body temperature (T(b)) decreased more (38.36+/-0.53 degrees C vs. 39.57+/-0.57 degrees C), body mass (m(b)) loss was greater (21.0+/-7.20 g vs.12.8+/-2.62g), and the energy saved by using hypothermia was greater (25.18-45.01% vs. 7.98-28.06%) in low the T(a) treatment than in TNZ treatment. Interestingly, the depth of hypothermia was positively correlated with m(b) loss in the low T(a) treatment, but not in TNZ treatment. Our data support H(3), that both thermoregulatory costs and body energy reserves are proximate cues for entry into hypothermia in quail. This outcome is not surprising below the T(lc). However, the quail kept at their TNZ also responded to food deprivation by entering hypothermia with no apparent dependence on m(b) loss. Therefore inputs, other than thermoregulatory costs and body condition, must serve as cues to enter hypothermia. Consequently, we address the role that tissue sparing may play in the physiological 'decision' to employ hypothermia. Copyright 2009 Elsevier Inc. All rights reserved.

Anti-parasitic effects of Leptomycin B isolated from Streptomyces sp. CJK17 on marine fish ciliate Cryptocaryon irritans.

PubMed

Yin, Fei; Sun, Peng; Tang, Baojun; Gong, Hui; Ke, Qiaozhen; Li, Anxing

2016-02-15

The present study was conducted aiming to evaluate the in vitro and in vivo anti-parasitic efficacy of an isolated compound against the ciliate Cryptocaryon irritans. The compound was previously isolated from fermentation products of Streptomyces sp. CJK17 and designated as SFrD. Toxicity of the compound SFrD against the fish hosts (Larimichthys crocea) was also tested and its chemical structure was elucidated. The obtained results showed that the compound has potent anti-parasitic efficacy with the 10 min-, 1 h-, 2 h-, 3 h- and 4 h-LC50 (95% Confidence Intervals) of 6.8 (6.5-7.1), 3.9 (2.8-5.0), 3.3 (2.6-4.0), 2.7 (2.3-3.1) and 2.5 (2.2-2.8) mg L(-1) against theronts of C. irritans and the 6h-LC50 (95% CI) of 3.0 (2.8-3.2) mg L(-1) against the tomonts, respectively. Exposure of the compound SFrD remarkably reduced the mortality of fish infected with C. Irritans, from 100% in the control group to 61.7% and 38.3% in groups of 3.1 mg L(-1) and 6.3 mg L(-1), respectively. In the test of exposing fish to 40 mg L(-1) compound SFrD for 24h, no visible effects were observed affecting the normal behavior or any macroscopic changes. By spectrum analysis (EI-MS, (1)H NMR and (13)C NMR), the compound SFrD was identified as Leptomycin B. This study firstly demonstrated that Leptomycin B has potent anti-parasitic efficacy against ciliates in cultured marine fish. Copyright © 2015 Elsevier B.V. All rights reserved.

Systematic Analysis of Intracellular-targeting Antimicrobial Peptides, Bactenecin 7, Hybrid of Pleurocidin and Dermaseptin, Proline–Arginine-rich Peptide, and Lactoferricin B, by Using Escherichia coli Proteome Microarrays*

PubMed Central

Ho, Yu-Hsuan; Shah, Pramod; Chen, Yi-Wen; Chen, Chien-Sheng

2016-01-01

Antimicrobial peptides (AMPs) act either through membrane lysis or by attacking intracellular targets. Intracellular targeting AMPs are a resource for antimicrobial agent development. Several AMPs have been identified as intracellular targeting peptides; however, the intracellular targets of many of these peptides remain unknown. In the present study, we used an Escherichia coli proteome microarray to systematically identify the protein targets of three intracellular targeting AMPs: bactenecin 7 (Bac7), a hybrid of pleurocidin and dermaseptin (P-Der), and proline-arginine-rich peptide (PR-39). In addition, we also included the data of lactoferricin B (LfcinB) from our previous study for a more comprehensive analysis. We analyzed the unique protein hits of each AMP in the Kyoto Encyclopedia of Genes and Genomes. The results indicated that Bac7 targets purine metabolism and histidine kinase, LfcinB attacks the transcription-related activities and several cellular carbohydrate biosynthetic processes, P-Der affects several catabolic processes of small molecules, and PR-39 preferentially recognizes proteins involved in RNA- and folate-metabolism-related cellular processes. Moreover, both Bac7 and LfcinB target purine metabolism, whereas LfcinB and PR-39 target lipopolysaccharide biosynthesis. This suggested that LfcinB and Bac7 as well as LfcinB and PR-39 have a synergistic effect on antimicrobial activity, which was validated through antimicrobial assays. Furthermore, common hits of all four AMPs indicated that all of them target arginine decarboxylase, which is a crucial enzyme for Escherichia coli survival in extremely acidic environments. Thus, these AMPs may display greater inhibition to bacterial growth in extremely acidic environments. We have also confirmed this finding in bacterial growth inhibition assays. In conclusion, this comprehensive identification and systematic analysis of intracellular targeting AMPs reveals crucial insights into the intracellular mechanisms of the action of AMPs. PMID:26902206

Systematic Analysis of Intracellular-targeting Antimicrobial Peptides, Bactenecin 7, Hybrid of Pleurocidin and Dermaseptin, Proline-Arginine-rich Peptide, and Lactoferricin B, by Using Escherichia coli Proteome Microarrays.

PubMed

Ho, Yu-Hsuan; Shah, Pramod; Chen, Yi-Wen; Chen, Chien-Sheng

2016-06-01

Antimicrobial peptides (AMPs) act either through membrane lysis or by attacking intracellular targets. Intracellular targeting AMPs are a resource for antimicrobial agent development. Several AMPs have been identified as intracellular targeting peptides; however, the intracellular targets of many of these peptides remain unknown. In the present study, we used an Escherichia coli proteome microarray to systematically identify the protein targets of three intracellular targeting AMPs: bactenecin 7 (Bac7), a hybrid of pleurocidin and dermaseptin (P-Der), and proline-arginine-rich peptide (PR-39). In addition, we also included the data of lactoferricin B (LfcinB) from our previous study for a more comprehensive analysis. We analyzed the unique protein hits of each AMP in the Kyoto Encyclopedia of Genes and Genomes. The results indicated that Bac7 targets purine metabolism and histidine kinase, LfcinB attacks the transcription-related activities and several cellular carbohydrate biosynthetic processes, P-Der affects several catabolic processes of small molecules, and PR-39 preferentially recognizes proteins involved in RNA- and folate-metabolism-related cellular processes. Moreover, both Bac7 and LfcinB target purine metabolism, whereas LfcinB and PR-39 target lipopolysaccharide biosynthesis. This suggested that LfcinB and Bac7 as well as LfcinB and PR-39 have a synergistic effect on antimicrobial activity, which was validated through antimicrobial assays. Furthermore, common hits of all four AMPs indicated that all of them target arginine decarboxylase, which is a crucial enzyme for Escherichia coli survival in extremely acidic environments. Thus, these AMPs may display greater inhibition to bacterial growth in extremely acidic environments. We have also confirmed this finding in bacterial growth inhibition assays. In conclusion, this comprehensive identification and systematic analysis of intracellular targeting AMPs reveals crucial insights into the intracellular mechanisms of the action of AMPs. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Functional interaction between nonreceptor tyrosine kinase c-Abl and SR-Rich protein RBM39

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mai, Sanyue; Qu, Xiuhua; Li, Ping

RBM39, also known as splicing factor HCC1.4, acts as a transcriptional coactivator for the steroid nuclear receptors JUN/AP-1, ESR1/ER-α and ESR2/ER-β. RBM39 is involved in the regulation of the transcriptional responses of these steroid nuclear receptors and promotes transcriptional initiation. In this paper, we report that RBM39 interacts with the nonreceptor tyrosine kinase c-Abl. Both the Src homology (SH) 2 and SH3 domains of c-Abl interact with RBM39. The major tyrosine phosphorylation sites on RBM39 that are phosphorylated by c-Abl are Y95 and Y99, as demonstrated by liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) and mutational analysis. c-Abl wasmore » shown boost the transcriptional coactivation activity of RBM39 for ERα and PRβ in a tyrosine kinase-dependent manner. The results suggest that mammalian c-Abl plays an important role in steroid hormone receptor-mediated transcription by regulating RBM39. - Highlights: • c-Abl interacts with RBM39. • RBM39 is phosphorylated by c-Abl. • c-Abl regulates transcriptional coactivation activity of RBM39 on the ERα and PRβ.« less

SKYLAB (SL)-III - LAUNCH - KSC

NASA Image and Video Library

1973-08-17

S73-32570 (28 July 1973) --- The Skylab 3/Saturn 1B space vehicle is launched from Pad B, Launch Complex 39, Kennedy Space Center, Florida, at 7:11 a.m. (EDT), Saturday, July 28, 1973. Skylab 3 is the second of three scheduled Skylab manned missions. Aboard the Skylab 3 Command/Service Module were astronauts Alan L. Bean, Owen K. Garriott and Jack R. Lousma. The Skylab 3 CSM later docked with the Skylab space station cluster in Earth orbit. In addition to the CSM and its launch escape system, the Skylab 3 space vehicle consisted of the Saturn 1B first (S-1B) stage and the Saturn 1B second (S-1VB) stage. (The Skylab 1/Saturn V space vehicle with the space station payload was launched from Pad A on May 14, 1973). Photo credit: NASA

41 CFR 101-39.003 - Financing.

Code of Federal Regulations, 2010 CFR

2010-07-01

... FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET..., and operation of fleet management systems. (b) When an agency other than GSA operates an interagency fleet management system, the financing and accounting methods shall be developed by GSA in cooperation...

Photocopy of drawing. VAB HB2 & 4 ET HOLDING CELLS, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of drawing. VAB HB-2 & 4 ET HOLDING CELLS, UPGRADE TO CHECKOUT CELLS. NASA John F. Kennedy Space Center, Florida. File Number 79K33180, Reynolds, Smith & Hill, February 1991. H.B.-2, PLANS AT LEVELS 4,5,&6. Sheet 7 - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

Photocopy of drawing. VAB HB2 & 4 ET HOLDING CELLS, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of drawing. VAB HB-2 & 4 ET HOLDING CELLS, UPGRADE TO CHECKOUT CELLS. NASA John F. Kennedy Space Center, Florida. File Number 79K33180, Reynolds, Smith & Hill, February 1991. H.B.-2, PLANS AT LEVELS 1,2,&3. Sheet 6 - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

Photocopy of drawing. VAB HB2 & 4 ET HOLDING CELLS, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of drawing. VAB HB-2 & 4 ET HOLDING CELLS, UPGRADE TO CHECKOUT CELLS. NASA John F. Kennedy Space Center, Florida. File Number 79K33180, Reynolds, Smith & Hill, February 1991. H.B.-2, PLANS AT LEVELS 7,8,&9. Sheet 8 - Cape Canaveral Air Force Station, Launch Complex 39, Vehicle Assembly Building, VAB Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

APOLLO 9 - PRELAUNCH (CDDT) - KSC

NASA Image and Video Library

1969-02-20

S69-27089 (11 March 1969) --- Overall view of Pad B, Launch Complex 39, Kennedy Space Center, showing the Apollo 10 (Spacecraft 106/Lunar Module-4/Saturn 505) space vehicle during a Countdown Demonstration Test. The Apollo 10 flight is scheduled as a lunar orbit mission. The Apollo 10 crew will be astronauts Thomas P. Stafford, commander; John W. Young, command module pilot; and Eugene A. Cernan, lunar module pilot.

Programmer’s Manual to Accompany the Yugoslav Dilemma (A Computer Simulation)

DTIC Science & Technology

1984-02-01

1 9505 QB = 1 9510 ON a OB + 39: IF ON )OL THEN ON OL 9515 0 a 0 1 9516 IF PEEK (16384 + OB) a 141 THEN PRINT :QB a 0B + 1: GOTO 9510 9520 FOR 02 a...APPLEWRITER INTO APPLESOFT CHARACTER STRINGS. 9500 PRINT D4s"BLOADTEXT.M"QI",AI4000":GL PEEK (43616) + PEEK (43617) ’ 256 - 1 9505 0B a I 9510 ON m 0B + 39...13.01 a 910 + INT ( RND (1) 8): GOSUB 9505 :A$ OSS COTO A 3190 3180 01 VAL (A$I):T% a QU% GOSUB 9505 -0T% = OU% 3190 GOSUB 9700ŔT% - 0 3191 B$(0) a OS

KSC-04pd2134

NASA Image and Video Library

2004-10-15

KENNEDY SPACE CENTER, FLA. - A tractor-trailer arrives at the Crawler Transporter (CT) area with a new shipment of crawler shoes. The new shoes were manufactured by ME Global in Duluth, Minn. The CT transports the Mobile Launcher Platform, with the assembled Space Shuttle aboard, between the refurbishment area, the VAB and Launch Complex Pads 39A and 39B. The crawlers have 456 shoes, 57 per belt (8 belts in all). Each shoe weighs 2,200 pounds. The original shoes were manufactured for the Apollo Program. Cracks appeared in the shoes in recent years spurring a need for replacement. The new manufacturer, in Duluth, Minn., has improved the design for Return to Flight and use through the balance of the Space Shuttle Program.

KSC-04pd2137

NASA Image and Video Library

2004-10-15

KENNEDY SPACE CENTER, FLA. - In the Crawler Transporter (CT) area, a worker places another load of new crawler shoes on the ground. The new shoes were manufactured by ME Global in Duluth, Minn. The CT transports the Mobile Launcher Platform, with the assembled Space Shuttle aboard, between the refurbishment area, the VAB and Launch Complex Pads 39A and 39B. The crawlers have 456 shoes, 57 per belt (8 belts in all). Each shoe weighs 2,200 pounds. The original shoes were manufactured for the Apollo Program. Cracks appeared in the shoes in recent years spurring a need for replacement. The new manufacturer, in Duluth, Minn., has improved the design for Return to Flight and use through the balance of the Space Shuttle Program.

η(4) -HBCC-σ,π-Borataallyl Complexes of Ruthenium Comprising an Agostic Interaction.

PubMed

Saha, Koushik; Joseph, Benson; Ramalakshmi, Rongala; Anju, R S; Varghese, Babu; Ghosh, Sundargopal

2016-06-01

Thermolysis of [Cp*Ru(PPh2 (CH2 )PPh2 )BH2 (L2 )] 1 (Cp*=η(5) -C5 Me5 ; L=C7 H4 NS2 ), with terminal alkynes led to the formation of η(4) -σ,π-borataallyl complexes [Cp*Ru(μ-H)B{R-C=CH2 }(L)2 ] (2 a-c) and η(2) -vinylborane complexes [Cp*Ru(R-C=CH2 )BH(L)2 ] (3 a-c) (2 a, 3 a: R=Ph; 2 b, 3 b: R=COOCH3 ; 2 c, 3 c: R=p-CH3 -C6 H4 ; L=C7 H4 NS2 ) through hydroboration reaction. Ruthenium and the HBCC unit of the vinylborane moiety in 2 a-c are linked by a unique η(4) -interaction. Conversions of 1 into 3 a-c proceed through the formation of intermediates 2 a-c. Furthermore, in an attempt to expand the library of these novel complexes, chemistry of σ-borane complex [Cp*RuCO(μ-H)BH2 L] 4 (L=C7 H4 NS2 ) was investigated with both internal and terminal alkynes. Interestingly, under photolytic conditions, 4 reacts with methyl propiolate to generate the η(4) -σ,π-borataallyl complexes [Cp*Ru(μ-H)BH{R-C=CH2 }(L)] 5 and [Cp*Ru(μ-H)BH{HC=CH-R}(L)] 6 (R=COOCH3 ; L=C7 H4 NS2 ) by Markovnikov and anti-Markovnikov hydroboration. In an extension, photolysis of 4 in the presence of dimethyl acetylenedicarboxylate yielded η(4) -σ,π-borataallyl complex [Cp*Ru(μ-H)BH{R-C=CH-R}(L)] 7 (R=COOCH3 ; L=C7 H4 NS2 ). An agostic interaction was also found to be present in 2 a-c and 5-7, which is rare among the borataallyl complexes. All the new compounds have been characterized in solution by IR, (1) H, (11) B, (13) C NMR spectroscopy, mass spectrometry and the structural types were unequivocally established by crystallographic analysis of 2 b, 3 a-c and 5-7. DFT calculations were performed to evaluate possible bonding and electronic structures of the new compounds. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Catalog of Space Shuttle Earth Observations Handheld Photography. Space Transportation System 39 (STS-39) Mission Dates: April 28 Through May 6, 1991

DTIC Science & Technology

1991-10-01

Albuquerque, NM 87131 Telephone: (505) 277-3622 Media Services Branch Still Photography Library NASA Lyndon B. Johnson Space Center P.O. Box 58425...organizations similarly equipped are the NASA Ames Research Center, California; the Library of Congress; the University of California at Santa Barbara; the Lunar...219 (M.S. 240-6) NASA Ames Research Center Moffett Field, CA 94305 (415) 604-6252 U.S. GOVERNMENT - LIBRARY OF CONGRESS Geography & Map Division Rm. B

Crawler Transporter 2 Trek

NASA Image and Video Library

2016-03-23

NASA’s upgraded crawler-transporter 2 (CT-2) begins its trek from the Vehicle Assembly Building (VAB) at the agency’s Kennedy Space Center in Florida to Launch Pad 39B to test recently completed upgrades and modifications for NASA’s journey to Mars. The Ground Systems Development and Operations Program at Kennedy oversaw upgrades to the crawler in the VAB. The crawler will carry the mobile launcher with Orion atop the Space Launch System rocket to Pad 39B for Exploration Mission-1, scheduled for 2018.

Crawler Transporter 2 Trek

NASA Image and Video Library

2016-03-23

NASA’s upgraded crawler-transporter 2 (CT-2) has exited the Vehicle Assembly Building (VAB) at the agency’s Kennedy Space Center in Florida for its trek along the crawlerway to Launch Pad 39B to test recently completed upgrades and modifications for NASA’s journey to Mars. The Ground Systems Development and Operations Program at Kennedy oversaw upgrades to the crawler in the VAB. The crawler will carry the mobile launcher with Orion atop the Space Launch System rocket to Pad 39B for Exploration Mission-1, scheduled for 2018.

Crawler Transporter 2 Trek

NASA Image and Video Library

2016-03-23

NASA’s upgraded crawler-transporter 2 (CT-2) travels along the crawlerway from the Vehicle Assembly Building (VAB) at the agency’s Kennedy Space Center in Florida on its trek to Launch Pad 39B to test recently completed upgrades and modifications for NASA’s journey to Mars. The Ground Systems Development and Operations Program at Kennedy oversaw upgrades to the crawler in the VAB. The crawler will carry the mobile launcher with Orion atop the Space Launch System rocket to Pad 39B for Exploration Mission-1, scheduled for 2018.

Crawler Transporter 2 Trek

NASA Image and Video Library

2016-03-23

NASA’s upgraded crawler-transporter 2 (CT-2) travels along the crawlerway during its trek to Launch Pad 39B at the agency’s Kennedy Space Center in Florida, to test recently completed upgrades and modifications for NASA’s journey to Mars. The Ground Systems Development and Operations Program at Kennedy oversaw upgrades to the crawler in the Vehicle Assembly Building. The crawler will carry the mobile launcher with Orion atop the Space Launch System rocket to Pad 39B for Exploration Mission-1, scheduled for 2018.

Endeavour on way to Pad 39B for STS-77

NASA Technical Reports Server (NTRS)

1996-01-01

A road sign points the way to Launch Pad 39B, the final earthly destination for the Space Shuttle Endeavour and its steppingstone into space. Endeavour began the slow journey from the Vehicle Assembly Building at about 10 a.m., April 16, perched atop the mobile launcher platform and carried by the crawler-transporter. Upcoming activities at the pad to prepare Endeavour for flight on Mission STS-77 include installation of the payloads in the orbiter's payload bay.

Pad 39B Flame Trench Brick Work

NASA Image and Video Library

2016-10-26

Progress continues on the new flame trench at Launch Pad 39B at NASA's Kennedy Space Center in Florida. Construction workers with J.P. Donovan of Rockledge, Florida, prepare new heat-resistant bricks for installation on the north side of the flame trench. The Pad B flame trench is being refurbished to support the launch of NASA’s Space Launch System rocket. The Ground Systems Development and Operations (GSDO) Program at Kennedy is helping transform the space center into a multi-user spaceport and prepare for Exploration Mission 1, deep space missions, and NASA's Journey to Mars. For more information about GSDO, visit: http://www.nasa.gov/groundsystems.

Pad 39B Flame Trench Brick Work

NASA Image and Video Library

2016-10-26

Progress continues on the new flame trench at Launch Pad 39B at NASA's Kennedy Space Center in Florida. Construction workers with J.P. Donovan of Rockledge, Florida, attach new heat-resistant bricks on the north side of the flame trench. The Pad B flame trench is being refurbished to support the launch of NASA’s Space Launch System rocket. The Ground Systems Development and Operations (GSDO) Program at Kennedy is helping transform the space center into a multi-user spaceport and prepare for Exploration Mission 1, deep space missions, and NASA's Journey to Mars. For more information about GSDO, visit: http://www.nasa.gov/groundsystems.

Pad 39B Flame Trench Brick Work

NASA Image and Video Library

2016-10-26

A construction worker with J.P. Donovan of Rockledge, Florida, checks to make sure new heat-resistant bricks attached to the north side of the flame trench are level at Launch Pad 39B at NASA’s Kennedy Space Center in Florida. The Pad B flame trench is being refurbished to support the launch of NASA’s Space Launch System rocket. The Ground Systems Development and Operations (GSDO) Program at Kennedy is helping transform the space center into a multi-user spaceport and prepare for Exploration Mission 1, deep space missions, and NASA's Journey to Mars. For more information about GSDO, visit: http://www.nasa.gov/groundsystems.

WILDLIFE - ALLIGATOR STROLLS FROM TURN BASIN TO LC 39 PRESS SITE GRANDSTAND

NASA Technical Reports Server (NTRS)

1985-01-01

A 12-foot alligator worked his way up from the turn basin at Press Site 39 to the grandstand seats. The toothy reptile was later wrangled by wildlife trappers who relocated him to a less populated area on KSC. The alligator is one of approximately 4,000 on KSC/Merritt Island National Wildlife Refuge.

41 CFR 101-39.403 - Investigation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... FEDERAL PROPERTY MANAGEMENT REGULATIONS AVIATION, TRANSPORTATION, AND MOTOR VEHICLES 39-INTERAGENCY FLEET... Interagency Fleet Management System (IFMS) vehicle shall be investigated and a report furnished to the manager of the GSA IFMS fleet management center which issued the vehicle. (b) The agency employing the...

Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site

PubMed Central

West, Anthony P; Schamber, Michael; Gazumyan, Anna; Golijanin, Jovana; Seaman, Michael S; Fätkenheuer, Gerd; Klein, Florian; Nussenzweig, Michel C; Bjorkman, Pamela J

2016-01-01

HIV-1 vaccine design is informed by structural studies elucidating mechanisms by which broadly neutralizing antibodies (bNAbs) recognize and/or accommodate N-glycans on the trimeric envelope glycoprotein (Env). Variability in high-mannose and complex-type Env glycoforms leads to heterogeneity that usually precludes visualization of the native glycan shield. We present 3.5-Å- and 3.9-Å-resolution crystal structures of the HIV-1 Env trimer with fully processed and native glycosylation, revealing a glycan shield of high-mannose and complex-type N-glycans, which we used to define complete epitopes of two bNAbs. Env trimer was complexed with 10-1074 (against the V3-loop) and IOMA, a new CD4-binding site (CD4bs) antibody. Although IOMA derives from VH1-2*02, the germline gene of CD4bs-targeting VRC01-class bNAbs, its light chain lacks the short CDRL3 that defines VRC01-class bNAbs. Thus IOMA resembles 8ANC131-class/VH1-46–derived CD4bs bNAbs, which have normal-length CDRL3s. The existence of bNAbs that combine features of VRC01-class and 8ANC131-class antibodies has implications for immunization strategies targeting VRC01-like bNAbs. PMID:27617431

NADH-ubiquinone oxidoreductase activity in the kinetoplasts of the plant trypanosomatid Phytomonas serpens.

PubMed

González-Halphen, Diego; Maslov, Dmitri A

2004-03-01

NADH-ubiquinone oxidoreductase activity is present in mitochondrial lysates of Phytomonas serpens. Rotenone at 2-10 microM inhibited the activity 50-75%, indicating that it belongs to respiratory complex I. The activity was also inhibited 50-60% in the presence of 10-30 nM atovaquone suggesting that inhibition of complex I represents a likely mechanism of the known antileishmanial activity of this drug. The complex was partially purified by chromatography on DEAE-Sepharose CL-6B and gel-filtration on Sepharose CL-2B. The NADH:ubiquinone oxidoreductase activity in this preparation was completely inactivated by 20 nM atovaquone. The partially purified complex was present in a low amount and its subunits could not be discerned by staining with Coomassie. However, one of its components, a homologue of the 39 kDa subunit of the bovine complex I, was identified immunochemically in the original lysate and in the partially purified material.

Human Follicular Lymphoma CD39+-Infiltrating T Cells Contribute to Adenosine-Mediated T Cell Hyporesponsiveness1

PubMed Central

Hilchey, Shannon P.; Kobie, James J.; Cochran, Mathew R.; Secor-Socha, Shelley; Wang, Jyh-Chiang E.; Hyrien, Ollivier; Burack, W. Richard; Mosmann, Tim R.; Quataert, Sally A.; Bernstein, Steven H.

2010-01-01

Our previous work has demonstrated that human follicular lymphoma (FL) infiltrating T cells are anergic, in part due to suppression by regulatory T cells. In this study, we identify pericellular adenosine, interacting with T cell-associated G protein-coupled A2A/B adenosine receptors (AR), as contributing to FL T cell hyporesponsiveness. In a subset of FL patient samples, treatment of lymph node mononuclear cells (LNMC) with specific A2A/B AR antagonists results in an increase in IFN-γ or IL-2 secretion upon anti-CD3/CD28 Ab stimulation, as compared with that seen without inhibitors. In contrast, treatment with an A1 AR antagonist had no effect on cytokine secretion. As the rate limiting step for adenosine generation from pericellular ATP is the ecto-ATPase CD39, we next show that inhibition of CD39 activity using the inhibitor ARL 67156 partially overcomes T cell hyporesponsiveness in a subset of patient samples. Phenotypic characterization of LNMC demonstrates populations of CD39-expressing CD4+ and CD8+ T cells, which are overrepresented in FL as compared with that seen in normal or reactive nodes, or normal peripheral blood. Thirty percent of the FL CD4+CD39+ T cells coexpress CD25high and FOXP3 (consistent with regulatory T cells). Finally, FL or normal LNMC hydrolyze ATP in vitro, in a dose- and time-dependent fashion, with the rate of ATP consumption being associated with the degree of CD39+ T cell infiltration. Together, these results support the finding that the ATP-ectonucleotidase-adenosine system mediates T cell anergy in a human tumor. In addition, these studies suggest that the A2A/B AR as well as CD39 are novel pharmacological targets for augmenting cancer immunotherapy. PMID:19864600

STS-57 Endeavour, OV-105, framed by Florida vegetation, lifts off from KSC LC

NASA Image and Video Library

1993-06-21

STS057-S-055 (21 June 1993) --- Framed by a variety of flora types, the Space Shuttle Endeavour lifts off Launch Pad 39B to begin the STS-57 mission. Launch occurred at 9:07:22 a.m. (EDT), June 21, 1993. The mission represents the first flight of the commercially developed SPACEHAB laboratory module and also will feature a retrieval of the European Retrievable Carrier (EURECA). Onboard for Endeavour's fourth flight are a crew of six - Ronald J. Grabe, mission commander; Brian Duffy, pilot; G. David Low, payload commander; and Nancy J. Sherlock, Peter J.K. (Jeff) Wisoff and Janice E. Voss, all mission specialists. An earlier launch attempt was scrubbed due to unacceptable weather conditions both at KSC and the overseas contingency landing sites.

39 CFR 222.3 - Other delegation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 39 Postal Service 1 2011-07-01 2011-07-01 false Other delegation. 222.3 Section 222.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION DELEGATIONS OF AUTHORITY § 222.3 Other delegation. (a) Documentation. All delegations of authority must be officially documented. (b...

39 CFR 222.3 - Other delegation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Other delegation. 222.3 Section 222.3 Postal Service UNITED STATES POSTAL SERVICE ORGANIZATION AND ADMINISTRATION DELEGATIONS OF AUTHORITY § 222.3 Other delegation. (a) Documentation. All delegations of authority must be officially documented. (b...

18 CFR 35.39 - Affiliate restrictions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Sales of Electric Energy, Capacity and Ancillary Services at Market-Based Rates § 35.39 Affiliate... authority, the conditions provided in this section, including the restriction on affiliate sales of electric... the Seller's market-based rate tariff. (b) Restriction on affiliate sales of electric energy or...

39. Historic American Buildings Survey John O. Brostrup, Photographer August ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

39. Historic American Buildings Survey John O. Brostrup, Photographer August 13, 1936 1:30 P. M. DETAIL OF SOUTH WALL-CENTRAL ROOM OF BASEMENT-UNIT B-BEFORE CHALKING. - General John Mason House, Analostan Island or Theodore Roosevelt Island, Washington, District of Columbia, DC

17 CFR Appendix B to Part 39 - Subpart C Election Form

Code of Federal Regulations, 2014 CFR

2014-04-01

... Commission's regulations. EXHIBIT F—RISK MANAGEMENT Attach, as Exhibit F, documents that demonstrate compliance with the risk management requirements set forth in § 39.36 of the Commission's regulations... identifiable location the derivatives clearing organization's responses to the Disclosure Framework for...

A sustainable on-line CapLC method for quantifying antifouling agents like irgarol-1051 and diuron in water samples: Estimation of the carbon footprint.

PubMed

Pla-Tolós, J; Serra-Mora, P; Hakobyan, L; Molins-Legua, C; Moliner-Martinez, Y; Campins-Falcó, P

2016-11-01

In this work, in-tube solid phase microextraction (in-tube SPME) coupled to capillary LC (CapLC) with diode array detection has been reported, for on-line extraction and enrichment of booster biocides (irgarol-1051 and diuron) included in Water Frame Directive 2013/39/UE (WFD). The analytical performance has been successfully demonstrated. Furthermore, in the present work, the environmental friendliness of the procedure has been quantified by means of the implementation of the carbon footprint calculation of the analytical procedure and the comparison with other methodologies previously reported. Under the optimum conditions, the method presents good linearity over the range assayed, 0.05-10μg/L for irgarol-1051 and 0.7-10μg/L for diuron. The LODs were 0.015μg/L and 0.2μg/L for irgarol-1051 and diuron, respectively. Precision was also satisfactory (relative standard deviation, RSD<3.5%). The proposed methodology was applied to monitor water samples, taking into account the EQS standards for these compounds. The carbon footprint values for the proposed procedure consolidate the operational efficiency (analytical and environmental performance) of in-tube SPME-CapLC-DAD, in general, and in particular for determining irgarol-1051 and diuron in water samples. Copyright © 2016 Elsevier B.V. All rights reserved.

Precise K-Ar, 40Ar/39Ar, Rb-Sr and U/Pb mineral ages from the 27.5 Ma fish canyon tuff reference standard

USGS Publications Warehouse

Lanphere, M.A.; Baadsgaard, H.

2001-01-01

The accuracy of ages measured using the 40Ar/39Ar technique is affected by uncertainties in the age of radiation fluence-monitor minerals. At present, there is lack of agreement about the ages of certain minerals used as fluence monitors. The accuracy of the age of a standard may be improved if the age can be measured using different decay schemes. This has been done by measuring ages on minerals from the Oligocene Fish Canyon Tuff (FCT) using the K-Ar, 40Ar/39Ar. Rb-Sr and U/Pb methods. K-Ar and 40Ar/39Ar total fusion ages of sanidine, biotite and hornblende yielded a mean age of 27.57 ?? 0.36 Ma. The weighted mean 40Ar/39Ar plateau age of sanidine and biotite is 27.57 ?? 0.18 Ma. A biotite-feldspar Rb-Sr isochron yielded an age of 27.44 ?? 0.16 Ma. The U-Pb data for zircon are complex because of the presence of Precambrian zircons and inheritance of radiogenic Pb. Zircons with 207Pb/235U < 0.4 yielded a discordia line with a lower concordia intercept of 27.52 ?? 0.09 Ma. Evaluation of the combined data suggests that the best age for FCT is 27.51 Ma. Published by Elsevier Science B.V.

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photocopy of drawing. MODIFICATIONS TO CONVERT ML NO. 3 TO MOBILE LAUNCHER PLATFORM NO. 1. NASA, John F. Kennedy Space Center, Florida. Drawing 79K04401, Reynolds, Smith and Hills, March, 1975. GENERAL ARRANGEMENT, MLP NO. 1, PLAN – DECK B. Sheet A14 - Cape Canaveral Air Force Station, Launch Complex 39, Mobile Launcher Platforms, Launcher Road, East of Kennedy Parkway North, Cape Canaveral, Brevard County, FL

Saturn Apollo Program

NASA Image and Video Library

1973-05-01

SA-206 lifts off from Kennedy Space Center's launch complex 39B, in Florida, on May 25, 1973, for the first manned Skylab mission (SL-2) with astronauts Pete Conrad, Joseph Kerwin, and Paul Weitz. The Saturn IB, developed under the direction of the Marshall Space Flight Center (MSFC), launched five manned Earth-orbital missions between 1968 and 1975: Apollo 7, Skylab 2, Skylab 3, Skylab 4, and the Apollo-Soyuz Test Project (ASTP).

The DnaK Chaperone Uses Different Mechanisms To Promote and Inhibit Replication of Vibrio cholerae Chromosome 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jha, Jyoti K.; Li, Mi; Ghirlando, Rodolfo

Replication of Vibrio cholerae chromosome 2 (Chr2) depends on molecular chaperone DnaK to facilitate binding of the initiator (RctB) to the replication origin. The binding occurs at two kinds of site, 12-mers and 39-mers, which promote and inhibit replication, respectively. Here we show that DnaK employs different mechanisms to enhance the two kinds of binding. We found that mutations inrctBthat reduce DnaK binding also reduce 12-mer binding and initiation. The initiation defect is suppressed by second-site mutations that increase 12-mer binding only marginally. Instead, they reduce replication inhibitory mechanisms: RctB dimerization and 39-mer binding. One suppressing change was in amore » dimerization domain which is folded similarly to the initiator of an iteron plasmid—the presumed progenitor of Chr2. In plasmids, DnaK promotes initiation by reducing dimerization. A different mutation was in the 39-mer binding domain of RctB and inactivated it, indicating an alternative suppression mechanism. Paradoxically, although DnaK increases 39-mer binding, the increase was also achieved by inactivating the DnaK binding site of RctB. This result suggests that the site inhibits the 39-mer binding domain (via autoinhibition) when prevented from binding DnaK. Taken together, our results reveal an important feature of the transition from plasmid to chromosome: the Chr2 initiator retains the plasmid-like dimerization domain and its control by chaperones but uses the chaperones in an unprecedented way to control the inhibitory 39-mer binding. IMPORTANCE The capacity of proteins to undergo remodeling provides opportunities to control their function. However, remodeling remains a poorly understood aspect of the structure-function paradigm due to its dynamic nature. Here we have studied remodeling of the initiator of replication ofVibrio choleraeChr2 by the molecular chaperone, DnaK. We show that DnaK binds to a site on the Chr2 initiator (RctB) that promotes initiation by reducing the initiator’s propensity to dimerize. Dimerization of the initiator of the putative plasmid progenitor of Chr2 is also reduced by DnaK, which promotes initiation. Paradoxically, the DnaK binding also promotes replication inhibition by reducing an autoinhibitory activity of RctB. In the plasmid-to-chromosome transition, it appears that the initiator has acquired an autoinhibitory activity and along with it a new chaperone activity that apparently helps to control replication inhibition independently of replication promotion.« less

Terrestrial and Celestial Cartography,

DTIC Science & Technology

1979-05-01

39 ANDROMEDA GALAXY.................................................. 39 DISCUSSION...boundary of the most visible region in each photograph. ANDROMEDA GALAXY The nearest spiral galaxy is in the Andromeda constellation. It is designated...Astrophysical Journal, 131, 265 (1960) 51 167. Photoelectmc Photometry of the Andromeda Nebula in the U, B, V System. G. de Vaucouleurs

Re-evaluation of Ipsilateral Radiation for T1-T2N0-N2b Tonsil Carcinoma at the Princess Margaret Hospital in the Human Papillomavirus Era, 25 Years Later

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huang, Shao Hui, E-mail: shaohui.huang@rmp.uhn.on.ca; Waldron, John; Department of Otolaryngology—Head & Neck Surgery, The Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario

Purpose: To report the outcome of ipsilateral radiation therapy (RT) in human papillomavirus (HPV)-positive (HPV+) patients and HPV-negative (HPV−) patients with T1-T2N0-N2b tonsillar cancer treated 25 years after our initial historical cohort. Methods and Materials: Patients with T1-T2N0-N2b tonsillar cancer who received ipsilateral RT or bilateral RT between 1999 and 2014 were reviewed. Overall survival (OS), local control (LC), regional control (RC), and grade 3 to 4 late toxicity (LT) were compared between ipsilateral RT and bilateral RT within HPV+ and HPV− patients, separately. Results: HPV status was ascertained in 379/427 (88%) consecutive patients (ipsilateral RT: 62 HPV+, 34 HPV−; bilateralmore » RT: 240 HPV+ 240, 41 HPV−). The proportion of ipsilateral RT by N category for HPV+ and HPV− patients were as follows: N0: 24/37 (65%) versus 28/48 (74%); N1: 21/49 (43%) versus 4/9 (44%); N2a: 10/39 (26%) versus 1/4 (25%); and N2b: 7/177 (4%) versus 1/24 (4%), respectively. Of the patients receiving ipsilateral RT, 94/96 (98%) were treated with RT alone. The median follow-up time was 5.03 years. The respective 5-year rates of OS, LC, RC, and LT were similar between ipsilateral RT and bilateral RT for the HPV+ patients (OS: 89% vs 87%, P=.55; LC: 97% vs 98%, P=.65; RC: 98% vs 97%, P=.27; LT: 17% vs 12%, P=.83) and HPV− patients (OS: 63% vs 48%, P=.27; LC: 90% vs 80%, P=.19; RC: 94% vs 83%, P=.14; LT: 15% vs 22%, P=.36). Of the 96 patients receiving ipsilateral RT, contralateral neck failure (CNF) occurred in 1/52 HPV+ patients and 1/34 HPV− patients. The 5-year CNF rates were 2% (95% CI: 1-9) (HPV+: 2% [0-14]; HPV−: 3% [0-21], P=.66). Five local failures (2 HPV+; 3 HPV−) and no distant failures were seen. The 5-year rates of LC, RC, and LT were 97% versus 90% (P=.24), 98% versus 94% (P=.25), and 18% versus 15% (P=.75) for the HPV+ and HPV− cohorts, respectively. Osteoradionecrosis occurred in 9 patients: 6/47 (13%) treated with conventional RT and 3/49 (6%) with intensity modulated RT (P=.32). Conclusion: Ipsilateral radiation to selected patients with T1-T2N0-N2b tonsillar cancer results in equally excellent outcomes regardless of tumor HPV status.« less

Worldwide Express: Exploiting Existing Contract Provisions to Maximize Savings

DTIC Science & Technology

2012-06-01

transportation lane for the case study, the author employed the Willie Sutton rule, looking for large sums of money first. Following the recommendation of a...profitable. The firm is a freight forwarder, not a small package operator like other WWX carriers. Freight forwarders generate profits by marking up...3,095.87 $3.39 $2,142.48 28 B 9 312 $3.19 $996.53 $3.39 $1,057.68 K 61 500 $5.04 $2,522.36 $3.39 $1,695.00 29 K 52 343 $5.61 $1,925.36 $3.39 $1,162.77 S

Mosquito larvicidal properties of Orthosiphon thymiflorus (Roth) Sleesen. (Family: Labiatae) against mosquito vectors, Anopheles stephensi, Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae).

PubMed

Kovendan, K; Murugan, K; Vincent, S; Barnard, Donald R

2012-04-01

To determine the mosquito larvicidal activities of hexane, chloroform, ethyl acetate, acetone and methanol leaf extract of Orthosiphon thymiflorus (O. thymiflorus) against Anopheles stephensi (An. stephensi), Culex quinquefasciatus (Cx. quinquefasciatus) and Aedes aegypti (Ae. aegypti). The larvicidal activity was assayed against three mosquito species at various concentrations ranging from (50-450 ppm) under the laboratory conditions. The LC(50) and LC(90) value of the O. thymiflorus leaf extract was determined by Probit analysis. The LC(50) values of hexane, chloroform, ethyl acetate, acetone and methanol extract of O. thymiflorus third instar larvae of An. stephensi were LC(50)= 201.39, 178.76, 158.06, 139.22 and 118.74 ppm; Cx. quinquefasciatus were LC(50)=228.13, 209.72, 183.35, 163.55 and 149.96 ppm and Ae. aegypti were LC(50)=215.65, 197.91, 175.05, 154.80 and 137.26 ppm, respectively. Maximum larvicidal activity was observed in the methanolic extract followed by acetone, ethyl acetate chloroform and hexane extract. The larval mortality was observed after 24 h exposure. No mortality was observed in control. The present results suggest that the effective plant crude extracts have potential to be used as an ideal eco-friendly approach for the control of mosquito vectors. This study provides the first report on the larvicidal activity of this plant crude solvent extract of against An. stephensi, Cx. quinquefasciatus and Ae. aegypti mosquitoes. Copyright © 2012 Hainan Medical College. Published by Elsevier B.V. All rights reserved.

Colorimetric detection of hydrogen peroxide by dioxido-vanadium(V) complex containing hydrazone ligand: synthesis and crystal structure

NASA Astrophysics Data System (ADS)

Kurbah, Sunshine D.; Syiemlieh, Ibanphylla; Lal, Ram A.

2018-03-01

Dioxido-vanadium(V) complex has been synthesized in good yield, the complex was characterized by IR, UV-visible and 1H NMR spectroscopy. Single crystal X-ray crystallography techniques were used to assign the structure of the complex. Complex crystallized with monoclinic P21/c space group with cell parameters a (Å) = 39.516(5), b (Å) = 6.2571(11), c (Å) = 17.424(2), α (°) = 90, β (°) = 102.668(12) and γ (°) = 90. The hydrazone ligand is coordinate to metal ion in tridentate fashion through -ONO- donor atoms forming a distorted square pyramidal geometry around the metal ion.

Pad 39B Flame Trench Brick Work

NASA Image and Video Library

2016-10-26

Progress continues on the new flame trench at Launch Pad 39B at NASA's Kennedy Space Center in Florida. Construction workers with J.P. Donovan of Rockledge, Florida, are on an elevated work stand to install new heat-resistant bricks on the north side of the flame trench. The Pad B flame trench is being refurbished to support the launch of NASA’s Space Launch System rocket. The Ground Systems Development and Operations (GSDO) Program at Kennedy is helping transform the space center into a multi-user spaceport and prepare for Exploration Mission 1, deep space missions, and NASA's Journey to Mars. For more information about GSDO, visit: http://www.nasa.gov/groundsystems.

Pad 39B Flame Trench Brick Work

NASA Image and Video Library

2016-10-26

Construction workers with J.P. Donovan of Rockledge, Florida, cut new heat-resistant bricks to size for the concrete walls of the flame trench at Launch Pad 39B at NASA’s Kennedy Space Center in Florida. New heat-resistant bricks are being attached with epoxy mortar to the flame trench walls. The Pad B flame trench is being refurbished to support the launch of NASA’s Space Launch System rocket. The Ground Systems Development and Operations (GSDO) Program at Kennedy is helping transform the space center into a multi-user spaceport and prepare for Exploration Mission 1, deep space missions, and NASA's Journey to Mars. For more information about GSDO, visit: http://www.nasa.gov/groundsystems.

Cryo Tank Fill at Pad 39B

NASA Image and Video Library

2017-09-26

Several Praxair trucks begin to depart Launch Pad 39B at NASA's Kennedy Space Center in Florida, after offloading their loads of liquid oxygen, or LO2, one at a time into the giant storage sphere located at the northwest corner of the pad. The sphere was gradually chilled down from normal temperature to about negative 298 degrees Fahrenheit, during the first major integrated operation to prepare for the launch of the agency's Orion spacecraft atop the Space Launch System (SLS) rocket. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to pad B to support the launch of the SLS and Orion spacecraft for Exploration Mission-1, deep space missions and NASA’s journey to Mars.

Cryo Tank Fill at Pad 39B

NASA Image and Video Library

2017-09-26

Several Praxair trucks carrying their loads of liquid oxygen, or LO2, arrive at Launch Pad 39B at NASA's Kennedy Space Center in Florida. The trucks will offload LO2 slowly into a giant storage sphere located at the northwest corner of the pad to gradually chill it down from normal temperature to about negative 298 degrees Fahrenheit, during the first major integrated operation to prepare for the launch of the agency's Orion spacecraft atop the Space Launch System (SLS) rocket. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to pad B to support the launch of the SLS and Orion spacecraft for Exploration Mission-1, deep space missions and NASA’s journey to Mars.

Cryo Tank Fill at Pad 39B

NASA Image and Video Library

2017-09-26

Mist or vapor is visible as a Praxair truck slowly transfers its load of liquid oxygen, or LO2, into a giant storage sphere at the northwest corner of Launch Pad 39B at NASA's Kennedy Space Center in Florida. The sphere will gradually be chilled down from normal temperature to about negative 298 degrees Fahrenheit, during the first major integrated operation to prepare for the launch of the agency's Orion spacecraft atop the Space Launch System (SLS) rocket. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to pad B to support the launch of the SLS and Orion spacecraft for Exploration Mission-1, deep space missions and NASA’s journey to Mars.

KSC-2010-4579

NASA Image and Video Library

2010-09-08

CAPE CANAVERAL, Fla. -- In the LC-39 Complex Turn Basin area across from the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida, a major water main leak in a 24-inch pipe caused soil to wash away near the Press Site. The center was closed for the morning while workers assessed and repaired the break. In the background is the Pegasus barge docked at the Turn Basin which is used to deliver the space shuttle external fuel tank. Photo credit: NASA/Jack Pfaller

KSC-2010-4582

NASA Image and Video Library

2010-09-08

CAPE CANAVERAL, Fla. -- In the LC-39 Complex Turn Basin area across from the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida, a major water main leak in a 24-inch pipe caused soil to wash away near the Press Site. The center was closed for the morning while workers assessed and repaired the break. In the background is the Pegasus barge docked at the Turn Basin which is used to deliver the space shuttle external fuel tank. Photo credit: NASA/Jack Pfaller

KSC-2010-4580

NASA Image and Video Library

2010-09-08

CAPE CANAVERAL, Fla. -- In the LC-39 Complex Turn Basin area across from the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida, a major water main leak in a 24-inch pipe caused soil to wash away near the Press Site. The center was closed for the morning while workers assessed and repaired the break. In the background is the Pegasus barge docked at the Turn Basin which is used to deliver the space shuttle external fuel tank. Photo credit: NASA/Jack Pfaller

Oleic acid is a key cytotoxic component of HAMLET-like complexes.

PubMed

Permyakov, Sergei E; Knyazeva, Ekaterina L; Khasanova, Leysan M; Fadeev, Roman S; Zhadan, Andrei P; Roche-Hakansson, Hazeline; Håkansson, Anders P; Akatov, Vladimir S; Permyakov, Eugene A

2012-01-01

HAMLET is a complex of α-lactalbumin (α-LA) with oleic acid (OA) that selectively kills tumor cells and Streptococcus pneumoniae. To assess the contribution of the proteinaceous component to cytotoxicity of HAMLET, OA complexes with proteins structurally and functionally distinct from α-LA were prepared. Similar to HAMLET, the OA complexes with bovine β-lactoglobulin (bLG) and pike parvalbumin (pPA) (bLG-OA-45 and pPA-OA-45, respectively) induced S. pneumoniae D39 cell death. The activation mechanisms of S. pneumoniae death for these complexes were analogous to those for HAMLET, and the cytotoxicity of the complexes increased with OA content in the preparations. The half-maximal inhibitory concentration for HEp-2 cells linearly decreased with rise in OA content in the preparations, and OA concentration in the preparations causing HEp-2 cell death was close to the cytotoxicity of OA alone. Hence, the cytotoxic action of these complexes against HEp-2 cells is induced mostly by OA. Thermal stabilization of bLG upon association with OA implies that cytotoxicity of bLG-OA-45 complex cannot be ascribed to molten globule-like conformation of the protein component. Overall, the proteinaceous component of HAMLET-like complexes studied is not a prerequisite for their activity; the cytotoxicity of these complexes is mostly due to the action of OA.

Crawler Transporter 2 Trek

NASA Image and Video Library

2016-03-23

An American flag flutters in the breeze as NASA’s upgraded crawler-transporter 2 (CT-2) travels along the crawlerway during its trek to Launch Pad 39B at the agency’s Kennedy Space Center in Florida, to test recently completed upgrades and modifications for NASA’s journey to Mars. The Ground Systems Development and Operations Program at Kennedy oversaw upgrades to the crawler in the Vehicle Assembly Building. The crawler will carry the mobile launcher with Orion atop the Space Launch System rocket to Pad 39B for Exploration Mission-1, scheduled for 2018.

Crawler Transporter 2 Trek

NASA Image and Video Library

2016-03-23

Technicians walk alongside NASA’s upgraded crawler-transporter 2 (CT-2) as it continues the trek on the crawlerway from the Vehicle Assembly Building (VAB) at the agency’s Kennedy Space Center in Florida to Launch Pad 39B to test recently completed upgrades and modifications for NASA’s journey to Mars. The Ground Systems Development and Operations Program at Kennedy oversaw upgrades to the crawler in the VAB. The crawler will carry the mobile launcher with Orion atop the Space Launch System rocket to Pad 39B for Exploration Mission-1, scheduled for 2018.

Crawler Transporter 2 Trek

NASA Image and Video Library

2016-03-23

Technicians walk alongside NASA’s upgraded crawler-transporter 2 (CT-2) as it continues the trek along the crawlerway from the Vehicle Assembly Building (VAB) at the agency’s Kennedy Space Center in Florida to Launch Pad 39B to test recently completed upgrades and modifications for NASA’s journey to Mars. The Ground Systems Development and Operations Program at Kennedy oversaw upgrades to the crawler in the VAB. The crawler will carry the mobile launcher with Orion atop the Space Launch System rocket to Pad 39B for Exploration Mission-1, scheduled for 2018.

Crawler Transporter 2 Trek

NASA Image and Video Library

2016-03-23

A truck sprays water in front of NASA’s upgraded crawler-transporter 2 (CT-2) to control dust as it begins the trek from the Vehicle Assembly Building (VAB) at the agency’s Kennedy Space Center in Florida to Launch Pad 39B to test recently completed upgrades and modifications for NASA’s journey to Mars. The Ground Systems Development and Operations Program at Kennedy oversaw upgrades to the crawler in the VAB. The crawler will carry the mobile launcher with Orion atop the Space Launch System rocket to Pad 39B for Exploration Mission-1, scheduled for 2018.

KSC-2013-2689

NASA Image and Video Library

2013-06-12

CAPE CANAVERAL, Fla. – At Launch Pad 39B at NASA’s Kennedy Space Center in Florida, crawler track panels have been removed from the surface and construction workers are repairing the concrete surface and catacomb roof below. Launch Pad 39B is being refurbished to support NASA’s Space Launch System and other launch vehicles. The Ground Systems Development and Operations, or GSDO, Program office at Kennedy is leading the center’s transformation to safely handle a variety of rockets and spacecraft. For more information about GSDO, visit: http://go.nasa.gov/groundsystems. Photo credit: NASA/Jim Grossman

KSC-2013-2610

NASA Image and Video Library

2013-06-10

CAPE CANAVERAL, Fla. – At Launch Pad 39B at NASA’s Kennedy Space Center in Florida, workers are removing the flame trench deflector that sits below and between the left and right crawler track panels. Launch Pad 39B is being refurbished to support NASA’s Space Launch System and other launch vehicles. The Ground Systems Development and Operations, or GSDO, Program office at Kennedy is leading the center’s transformation to safely handle a variety of rockets and spacecraft. For more information about GSDO, visit: http://go.nasa.gov/groundsystems. Photo credit: NASA/Jim Grossman

Synchronisation of Cold Induced Vasodilation in the Fingers of Two Immersed Hands

DTIC Science & Technology

1992-10-14

TNO Institute for Perception TNO Defence Research "D SYL--. j. 1O)rowort IZF 1992 B-l SYNCHRONISATION OF COLD INDUCED H.A.M. Daanen VASODILATION IN...Defence Research KPmN, 3,9Z( TD (.L - ?29 ’- . The Net Fax +313463 5 39 77 Telephone +31 3463 5 62 11 TNO.-rport IZF 1992 B-11 SYNCHRONISATION OF COLD...DISCUSSION 12 5 CONCLUSIONS 15 REFERENCES 16 Report No.: IZF 1992 - I1 Title: Synchronisation of cold induced vasodilation in the fingers (f two immersed

KSC-2009-1334

NASA Image and Video Library

2009-01-26

CAPE CANAVERAL, Fla. – On Launch Pad 39B at NASA's Kennedy Space Center in Florida, a crane begins lifting a 100-foot fiberglass lightning mast to place it on top of one of the 500-foot towers being constructed for the Constellation Program and Ares/Orion launches. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009.

KSC-2009-1333

NASA Image and Video Library

2009-01-26

CAPE CANAVERAL, Fla. – On Launch Pad 39B at NASA's Kennedy Space Center in Florida, a crane begins lifting a 100-foot fiberglass lightning mast to place it on top of one of the 500-foot towers being constructed for the Constellation Program and Ares/Orion launches. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009.

KSC-2009-1331

NASA Image and Video Library

2009-01-26

CAPE CANAVERAL, Fla. – On Launch Pad 39B at NASA's Kennedy Space Center in Florida, a crane lifts a 100-foot fiberglass lightning mast that will be placed on top of one of the 500-foot towers being constructed for the Constellation Program and Ares/Orion launches. This improved lightning protection system allows for the taller height of the Ares I rocket compared to the space shuttle. Pad 39B will be the site of the first Ares vehicle launch, including the Ares I-X test flight that is targeted for July 2009.