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Sample records for complex transient events

  1. Analyses Of Transient Events In Complex Valve and Feed Systems

    NASA Technical Reports Server (NTRS)

    Ahuja, Vineet; Hosangadi, Ashvin; Cavallo, Peter; Daines, Russell

    2005-01-01

    Valve systems in rocket propulsion systems and testing facilities are constantly subject to dynamic events resulting from the timing of valve motion leading to unsteady fluctuations in pressure and mass flow. Such events can also be accompanied by cavitation, resonance, system vibration leading to catastrophic failure. High-fidelity dynamic computational simulations of valve operation can yield important information of valve response to varying flow conditions. Prediction of transient behavior related to valve motion can serve as guidelines for valve scheduling, which is of crucial importance in engine operation and testing. In this paper, we present simulations of the diverse unsteady phenomena related to valve and feed systems that include valve stall, valve timing studies as well as cavitation instabilities in components utilized in the test loop.

  2. Model complexity affects transient population dynamics following a dispersal event: a case study with pea aphids.

    PubMed

    Tenhumberg, Brigitte; Tyre, Andrew J; Rebarber, Richard

    2009-07-01

    Stage-structured population models predict transient population dynamics if the population deviates from the stable stage distribution. Ecologists' interest in transient dynamics is growing because populations regularly deviate from the stable stage distribution, which can lead to transient dynamics that differ significantly from the stable stage dynamics. Because the structure of a population matrix (i.e., the number of life-history stages) can influence the predicted scale of the deviation, we explored the effect of matrix size on predicted transient dynamics and the resulting amplification of population size. First, we experimentally measured the transition rates between the different life-history stages and the adult fecundity and survival of the aphid, Acythosiphon pisum. Second, we used these data to parameterize models with different numbers of stages. Third, we compared model predictions with empirically measured transient population growth following the introduction of a single adult aphid. We find that the models with the largest number of life-history stages predicted the largest transient population growth rates, but in all models there was a considerable discrepancy between predicted and empirically measured transient peaks and a dramatic underestimation of final population sizes. For instance, the mean population size after 20 days was 2394 aphids compared to the highest predicted population size of 531 aphids; the predicted asymptotic growth rate (lamdamax) was consistent with the experiments. Possible explanations for this discrepancy are discussed.

  3. Single-Event Transients in Voltage Regulators

    NASA Technical Reports Server (NTRS)

    Johnston, Allan H.; Miyahira, Tetsuo F.; Irom, F.; Laird, Jamie S.

    2006-01-01

    Single-event transients are investigated for two voltage regulator circuits that are widely used in space. A circuit-level model is developed that can be used to determine how transients are affected by different circuit application conditions. Internal protection circuits-which are affected by load as well as internal thermal effects-can also be triggered from heavy ions, causing dropouts or shutdown ranging from milliseconds to seconds. Although conventional output transients can be reduced by adding load capacitance, that approach is ineffective for dropouts from protection circuitry.

  4. Single-Event Transients in Voltage Regulators

    NASA Technical Reports Server (NTRS)

    Johnston, Allan H.; Miyahira, Tetsuo F.; Irom, F.; Laird, Jamie S.

    2006-01-01

    Single-event transients are investigated for two voltage regulator circuits that are widely used in space. A circuit-level model is developed that can be used to determine how transients are affected by different circuit application conditions. Internal protection circuits-which are affected by load as well as internal thermal effects-can also be triggered from heavy ions, causing dropouts or shutdown ranging from milliseconds to seconds. Although conventional output transients can be reduced by adding load capacitance, that approach is ineffective for dropouts from protection circuitry.

  5. Imaging transient events at high angular resolution

    NASA Astrophysics Data System (ADS)

    Schaefer, Gail H.

    2016-08-01

    Resolving the spatial structure of transient events provides insights into their physical nature and origin. Recent observations using long baseline optical/infrared interferometry have revealed the size, shape, and angular expansion of bright novae within a few days after their outbursts. This has implications for understanding the timescale for the development of asymmetric features in novae ejecta. Additionally, combining spectroscopic measurements of the expansion velocity with the angular expansion rate provides a way to measure a geometric distance to the nova. In this paper, I provide a review of interferometric observations of novae, with a focus on recent results on the expansion and spatial structure of nova V339 Del in 2013. I also discuss other promising applications of interferometry to transient sources, such as measuring the image size and centroid displacements to measure planetary masses in gravitational microlensing events. Given the timescales of transient events, it is critical for interferometric arrays to respond rapidly to targets of opportunity in order to optimize the instrumental sensitivity and baselines required to resolve the source while its brightness and size change over time.

  6. Complex Event Recognition Architecture

    NASA Technical Reports Server (NTRS)

    Fitzgerald, William A.; Firby, R. James

    2009-01-01

    Complex Event Recognition Architecture (CERA) is the name of a computational architecture, and software that implements the architecture, for recognizing complex event patterns that may be spread across multiple streams of input data. One of the main components of CERA is an intuitive event pattern language that simplifies what would otherwise be the complex, difficult tasks of creating logical descriptions of combinations of temporal events and defining rules for combining information from different sources over time. In this language, recognition patterns are defined in simple, declarative statements that combine point events from given input streams with those from other streams, using conjunction, disjunction, and negation. Patterns can be built on one another recursively to describe very rich, temporally extended combinations of events. Thereafter, a run-time matching algorithm in CERA efficiently matches these patterns against input data and signals when patterns are recognized. CERA can be used to monitor complex systems and to signal operators or initiate corrective actions when anomalous conditions are recognized. CERA can be run as a stand-alone monitoring system, or it can be integrated into a larger system to automatically trigger responses to changing environments or problematic situations.

  7. Single Event Transients in Linear Integrated Circuits

    NASA Technical Reports Server (NTRS)

    Buchner, Stephen; McMorrow, Dale

    2005-01-01

    On November 5, 2001, a processor reset occurred on board the Microwave Anisotropy Probe (MAP), a NASA mission to measure the anisotropy of the microwave radiation left over from the Big Bang. The reset caused the spacecraft to enter a safehold mode from which it took several days to recover. Were that to happen regularly, the entire mission would be compromised, so it was important to find the cause of the reset and, if possible, to mitigate it. NASA assembled a team of engineers that included experts in radiation effects to tackle the problem. The first clue was the observation that the processor reset occurred during a solar event characterized by large increases in the proton and heavy ion fluxes emitted by the sun. To the radiation effects engineers on the team, this strongly suggested that particle radiation might be the culprit, particularly when it was discovered that the reset circuit contained three voltage comparators (LM139). Previous testing revealed that large voltage transients, or glitches appeared at the output of the LM139 when it was exposed to a beam of heavy ions [NI96]. The function of the reset circuit was to monitor the supply voltage and to issue a reset command to the processor should the voltage fall below a reference of 2.5 V [PO02]. Eventually, the team of engineers concluded that ionizing particle radiation from the solar event produced a negative voltage transient on the output of one of the LM139s sufficiently large to reset the processor on MAP. Fortunately, as of the end of 2004, only two such resets have occurred. The reset on MAP was not the first malfunction on a spacecraft attributed to a transient. That occurred shortly after the launch of NASA s TOPEX/Poseidon satellite in 1992. It was suspected, and later confirmed, that an anomaly in the Earth Sensor was caused by a transient in an operational amplifier (OP-15) [KO93]. Over the next few years, problems on TDRS, CASSINI, [PR02] SOHO [HA99,HA01] and TERRA were also attributed

  8. Heinrich events modeled in transient glacial simulations

    NASA Astrophysics Data System (ADS)

    Ziemen, Florian; Kapsch, Marie; Mikolajewicz, Uwe

    2017-04-01

    Heinrich events are among the most prominent events of climate variability recorded in proxies across the northern hemisphere. They are the archetype of ice sheet — climate interactions on millennial time scales. Nevertheless, the exact mechanisms that cause Heinrich events are still under debate, and their climatic consequences are far from being fully understood. We address open questions by studying Heinrich events in a coupled ice sheet model (ISM) atmosphere-ocean-vegetation general circulation model (AOVGCM) framework, where this variability occurs as part of the model generated internal variability. The framework consists of a northern hemisphere setup of the modified Parallel Ice Sheet Model (mPISM) coupled to the global AOVGCM ECHAM5/MPIOM/LPJ. The simulations were performed fully coupled and with transient orbital and greenhouse gas forcing. They span from several millennia before the last glacial maximum into the deglaciation. To make these long simulations feasible, the atmosphere is accelerated by a factor of 10 relative to the other model components using a periodical-synchronous coupling technique. To disentangle effects of the Heinrich events and the deglaciation, we focus on the events occurring before the deglaciation. The modeled Heinrich events show a peak ice discharge of about 0.05 Sv and raise the sea level by 2.3 m on average. The resulting surface water freshening reduces the Atlantic meridional overturning circulation and ocean heat release. The reduction in ocean heat release causes a sub-surface warming and decreases the air temperature and precipitation regionally and downstream into Eurasia. The surface elevation decrease of the ice sheet enhances moisture transport onto the ice sheet and thus increases precipitation over the Hudson Bay area, thereby accelerating the recovery after an event.

  9. What drives transient behavior in complex systems?

    NASA Astrophysics Data System (ADS)

    Grela, Jacek

    2017-08-01

    We study transient behavior in the dynamics of complex systems described by a set of nonlinear ordinary differential equations. Destabilizing nature of transient trajectories is discussed and its connection with the eigenvalue-based linearization procedure. The complexity is realized as a random matrix drawn from a modified May-Wigner model. Based on the initial response of the system, we identify a novel stable-transient regime. We calculate exact abundances of typical and extreme transient trajectories finding both Gaussian and Tracy-Widom distributions known in extreme value statistics. We identify degrees of freedom driving transient behavior as connected to the eigenvectors and encoded in a nonorthogonality matrix T0. We accordingly extend the May-Wigner model to contain a phase with typical transient trajectories present. An exact norm of the trajectory is obtained in the vanishing T0 limit where it describes a normal matrix.

  10. Air Heating Associated with Transient Luminous Events

    NASA Astrophysics Data System (ADS)

    Riousset, J. A.; Pasko, V. P.; Bourdon, A.

    2009-12-01

    The understanding of ambient gas heating processes initiated by needle-shaped filaments of ionization, called streamers, embedded in originally cold air (near room temperature) represents a long standing problem, which is of interest for studies of long laboratory sparks and natural lightning discharges [e.g., Gallimberti et al., C. R. Physique, 3, 1335, 2002]. The observed phenomenology of a subset of the recently observed transient luminous events in the middle atmosphere, which originate from thundercloud tops [e.g, Wescott et al., JGR, 106, 21549, 2001; Pasko et al., Nature, 416, 152, 2002; Su et al., Nature, 423, 974, 2003; Krehbiel et al., Nature Geoscience, 1, 233, 2008; Cummer et al., Nature Geoscience, 2, 617, 2009, Riousset et al., JGR, 10.1029/2009JA014286, 2009, in press], indicate that these events may be related to conventional lightning leader processes and therefore are associated with significant heating of the air in the regions of atmosphere through which they propagate [Pasko and George, JGR, 107, 1458, 2002]. Many of the small scale features observed in sprites at higher altitudes [e.g., Stenbaek-Nielsen et al., GRL, 104, L11105, 2007, and references therein] can be interpreted in terms of corona streamers, which, after appropriate scaling with air density, are fully analogous to those, which initiate spark discharges in relatively short (several cm) gaps at near ground pressure [Liu et al., JGR, 114, A00E03, 2009, and references therein] and which constitute building blocks of streamer zones of conventional lightning leaders in long gaps [Gallimberti et al., 2002]. The recent reports of infrasound bursts originating from 60-80 km altitudes in sprites, with durations consistent with the optical widths of the sprites [e.g., Farges, in Lightning: Principles, Instruments and Applications, p. 417, Betz et al., (eds.), Springer, 2009], provide an additional motivation for studies of the heating of the ambient air and associated chemical effects

  11. Analysis and Simulations of Space Radiation Induced Single Event Transients

    NASA Astrophysics Data System (ADS)

    Perez, Reinaldo

    2016-05-01

    Spacecraft electronics are affected by the space radiation environment. Among the different types of radiation effects that can affect spacecraft electronics is the single event transients. The space environment is responsible for many of the single event transients which can upset the performance of the spacecraft avionics hardware. In this paper we first explore the origins of single event transients, then explore the modeling of a single event transient in digital and analog circuit. The paper also addresses the concept of crosstalk that could develop among digital circuits in the present of a SET event. The paper ends with a brief discussion of SET hardening. The goal of the paper is to provide methodologies for assessing single event transients and their effects so that spacecraft avionics engineers can develop either hardware or software countermeasures in their designs.

  12. Remote Sensing of Transient Luminous Events

    NASA Astrophysics Data System (ADS)

    Fullekrug, M.; Whitley, T.; Mezentsev, A.; van der Velde, O. A.; Soula, S.; Chanrion, O.; Neubert, T.; Roussel-Dupre, R. A.

    2012-12-01

    Transient Luminous Events are investigated by remote sensing with several networks of radio receivers. Spectacular sprites are detected by use of their characteristic signatures following the continuing current of their parent positive cloud to ground lightning discharges which are recorded with a global network of four radio receivers operating at a frequency range from ~1-1000 Hz. This novel data set reveals a new class of sprites, where the intensity of the sprite exceeds the intensity of the parent lightning discharge, presumably as a result of continued horizontal lightning activity. These Mega-Sprites occur mainly during night-time and with a likelihood of less than ~10% during day-time. The spectra of Mega-Sprites are inferred from the electromagnetic recordings. Sprites with more moderate luminousity are occaisonally associated with weak electromagnetic signatures in the frequency range from ~40-400 kHz. It is shown that one of these signatures coincides with an extremely weak rebrightening of an ongoing sprite. The rebrightening exhibits an emission of ~50 photons over ~1 ms as measured with a fast scanning photomultiplier tube. This optical signature may result from relativisitc electrons in the mesosphere in agreement with corresponding model calculations. To test this hypothesis in more detail, a network of ten wideband digital radio receivers is deployed in southern France to operate as a small scale interferometer. The first results are obatined at a frequency of 100 kHz and show the bearings to radio transmitters and lightning discharges from distant thunderstorms and reveal an anisotropic wave propagation velocity.

  13. Diagnosing transient ionization in dynamic events

    NASA Astrophysics Data System (ADS)

    Doyle, J. G.; Giunta, A.; Madjarska, M. S.; Summers, H.; O'Mullane, M.; Singh, A.

    2013-09-01

    Aims: The present study aims to provide a diagnostic line ratio that will enable the observer to determine whether a plasma is in a state of transient ionization. Methods: We use the Atomic Data and Analysis Structure (ADAS) to calculate line contribution functions for two lines, Si iv 1394 Å and O iv 1401 Å, formed in the solar transition region. The generalized collisional-radiative theory is used. It includes all radiative and electron collisional processes, except for photon-induced processes. State-resolved direct ionization and recombination to and from the next ionization stage are also taken into account. Results: For dynamic bursts with a decay time of a few seconds, the Si iv 1394 Å line can be enhanced by a factor of 2-4 in the first fraction of a second with the peak in the line contribution function occurring initially at a higher electron temperature due to transient ionization compared to ionization equilibrium conditions. On the other hand, the O iv 1401 Å does not show such any enhancement. Thus the ratio of these two lines, which can be observed with the Interface Region Imaging Spectrograph, can be used as a diagnostic of transient ionization. Conclusions: We show that simultaneous high-cadence observations of two lines formed in the solar transition region may be used as a direct diagnostic of whether the observed plasma is in transient ionization. The ratio of these two lines can change by a factor of four in a few seconds owing to transient ionization alone.

  14. Single Event Transients in Low Voltage Dropout (LVDO) Voltage Regulators

    NASA Technical Reports Server (NTRS)

    LaBel, K.; Karsh, J.; Pursley, S.; Kleyner, I.; Katz, R.; Poivey, C.; Kim, H.; Seidleck, C.

    2006-01-01

    This viewgraph presentation reviews the use of Low Voltage Dropout (LVDO) Voltage Regulators in environments where heavy ion induced Single Event Transients are a concern to the designers.Included in the presentation are results of tests of voltage regulators.

  15. Current transients in single nanoparticle collision events.

    PubMed

    Xiao, Xiaoyin; Fan, Fu-Ren F; Zhou, Jiping; Bard, Allen J

    2008-12-10

    Electrochemical hydrazine oxidation and proton reduction occur at a significantly higher rate at Pt than at Au or C electrodes. Thus, the collision and adhesion of a Pt particle on a less active Au or C electrode leads to a large current amplification by electrocatalysis at single nanoparticles (NPs). At low particle concentrations, the collision of Pt NPs was characterized by current transients composed of individual current profiles that rapidly attained a steady state, signaling single NP collisions. The characteristic steady-state current was used to estimate the particle size. The fluctuation in collision frequency with time indicates that the collision of NPs at the detector electrodes occurs in a statistically random manner, with the average frequency a function of particle concentration and diffusion coefficient. A longer term current decay in single current transients, as opposed to the expected steady-state behavior, was more pronounced for proton reduction than for hydrazine oxidation, revealing microscopic details of the nature of the particle interaction with the detector electrode and the kinetics of electrocatalysis at single NPs. The study of single NP collisions allows one to screen particle size distributions and estimate NP concentrations and diffusion coefficients.

  16. Detection of transient events in the presence of background noise.

    PubMed

    Grange, Wilfried; Haas, Philippe; Wild, Andreas; Lieb, Michael Andreas; Calame, Michel; Hegner, Martin; Hecht, Bert

    2008-06-12

    We describe a method to detect and count transient burstlike signals in the presence of a significant stationary noise. To discriminate a transient signal from the background noise, an optimum threshold is determined using an iterative algorithm that yields the probability distribution of the background noise. Knowledge of the probability distribution of the noise then allows the determination of the number of transient events with a quantifiable error (wrong-positives). We apply the method, which does not rely on the choice of free parameters, to the detection and counting of transient single-molecule fluorescence events in the presence of a strong background noise. The method will be of importance in various ultra sensing applications.

  17. HAWC and Solar Energetic Transient Events

    NASA Astrophysics Data System (ADS)

    Lara, A.; Ryan, J. M.

    2013-12-01

    The High Altitude Water Cherenkov (HAWC) observatory is being constructed at the volcano Sierra Negra (4100 m a.s.l.) in Mexico. HAWC's primary purpose is the study of both galactic and extra-galactic sources of high energy gamma rays. The HAWC instrument will consist of 300 large water Cherenkov detectors whose counting rate will be sensitive to cosmic rays with energies above the geomagnetic cutoff of the site ( ˜ 8 GV). In particular, HAWC will detect solar energetic particles known as Ground Level Enhancements (GLEs), and the effect of Coronal Mass Ejections on the galactic cosmic rays, known as Forbush Decreases (FDs). The Milagro experiment, the HAWC predecessor, successfully observed GLEs and the HAWC engineering array "VAMOS" already observed a FD. HAWC will be sensitive to γ rays and neutrons produced during large solar flares. In this work, we present the instrument and discuss its capability to observe solar energetic events. i. e., flares and CMEs.

  18. A space-based radio frequency transient event classifier

    SciTech Connect

    Moore, K.R.; Blain, C.P.; Caffrey, M.P.; Franz, R.C.; Henneke, K.M.; Jones, R.G.

    1998-03-01

    The Department of Energy is currently investigating economical and reliable techniques for space-based nuclear weapon treaty verification. Nuclear weapon detonations produce RF transients that are signatures of illegal nuclear weapons tests. However, there are many other sources of RF signals, both natural and man-made. Direct digitization of RF signals requires rates of 300 MSamples per second and produces 10{sup 13} samples per day of data to analyze. it is impractical to store and downlink all digitized RF data from such a satellite without a prohibitively expensive increase in the number and capacities of ground stations. Reliable and robust data processing and information extraction must be performed onboard the spacecraft in order to reduce downlinked data to a reasonable volume. The FORTE (Fast On-Orbit Recording of Transient Events) satellite records RF transients in space. These transients will be classified onboard the spacecraft with an Event Classifier specialized hardware that performs signal preprocessing and neural network classification. The authors describe the Event Classifier requirements, scientific constraints, design and implementation.

  19. An Android application for receiving notifications of astrophysical transient events

    NASA Astrophysics Data System (ADS)

    Zhao, Y.; Bond, I. A.; Sweatman, W. L.

    2014-10-01

    We describe an application written for the Android platform for receiving real-time notifications of astrophysical transient events. The key feature of our application is the use of message oriented middleware as a message broker, with the messages in VOEvent format. We describe the design features and implementation details of our application. In particular, it was necessary to implement support for the Simple Text Oriented Messaging Protocol (STOMP) to allow communication with the broker. Our application is designed around VOEvent alerts from the Microlensing Observations in Astrophysics (MOA) project, but could easily be adapted for other surveys that issue VOEvent notices of astrophysical transients.

  20. Marine Productivity During Transient Climate Events: A new Outlook

    NASA Astrophysics Data System (ADS)

    Bralower, T. J.; Eleson, J. W.; Bowman, A. R.; Thomas, D. J.; Zachos, J. C.

    2001-12-01

    Transient climate events often led to profound changes in ocean circulation. This modified circulation has in turn led to increase or decrease in the supply of nutrients to surface waters, both delivered from the continents via runoff and upwelled from the deep ocean. Paleoceanographers have often painted a black and white picture of productivity change during transient climate events. For example, Cretaceous Oceanic Anoxic Events (OAEs) have been thought of as periods of high oceanic productivity as indicated by the abundance of siliceous microfossils in particular black shale horizons and by planktic foraminiferal carbon isotope data. The Late Paleocene Thermal Maximum (LPTM) is also regarded as a high productivity interval based on Ba accumulation rates and increases in the abundance of detritus-feeding benthic foraminifera. We present nannoplankton assemblage data illustrating that it is impossible to generalize about productivity changes on an ocean-wide basis for any transient climate event. Data from Site 690 in the Southern Ocean show a major assemblage shift at the onset of the LPTM. This shift suggests a change from colder, more productive surface waters to warmer, more nutrient-starved conditions. The data also indicate that surface-water conditions became slightly cooler and more productive towards the end of the event. Similarly, nannoplankton assemblage data from sections in Kansas in the Western Interior Seaway and the New Jersey coastal plain also indicate reduced productivity at the onset of OAE2 at the Cenomanian/Turonian Boundary. This is in sharp contrast to current hypotheses regarding the origin of anoxia and organic matter accumulation. In both sections, productivity appears to increase in the later part of the event. Combined with other microfossil assemblage and geochemical data, nannoplankton assemblage data suggest sequestration of nutrients in shelf environments and starvation of the open ocean during the LPTM. The inverse scenario seems

  1. Discovery, classification, and scientific exploration of transient events from the Catalina Real-time Transient Survey

    NASA Astrophysics Data System (ADS)

    Mahabal, A. A.; Djorgovski, S. G.; Drake, A. J.; Donalek, C.; Graham, M. J.; Williams, R. D.; Chen, Y.; Moghaddam, B.; Turmon, M.; Beshore, E.; Larson, S.

    2011-09-01

    Exploration of the time domain -- variable and transient objects and phenomena -- is rapidly becoming a vibrant research frontier, touching on essentially every field of astronomy and astrophysics, from the Solar system to cosmology. Time domain astronomy is being enabled by the advent of the new generation of synoptic sky surveys that cover large areas on the sky repeatedly, and generating massive data streams. Their scientific exploration poses many challenges, driven mainly by the need for a real-time discovery, classification, and follow-up of the interesting events. Here we describe the Catalina Real-Time Transient Survey (CRTS), that discovers and publishes transient events at optical wavelengths in real time, thus benefiting the entire community. We describe some of the scientific results to date, and then focus on the challenges of the automated classification and prioritization of transient events. CRTS represents a scientific and a technological testbed and precursor for the larger surveys in the future, including the Large Synoptic Survey Telescope (LSST) and the Square Kilometer Array (SKA).

  2. Analysis and RHBD technique of single event transients in PLLs

    NASA Astrophysics Data System (ADS)

    Zhiwei, Han; Liang, Wang; Suge, Yue; Bing, Han; Shougang, Du

    2015-11-01

    Single-event transient susceptibility of phase-locked loops has been investigated. The charge pump is the most sensitive component of the PLL to SET, and it is hard to mitigate this effect at the transistor level. A test circuit was designed on a 65 nm process using a new system-level radiation-hardening-by-design technique. Heavy-ion testing was used to evaluate the radiation hardness. Analyses and discussion of the feasibility of this method are also presented.

  3. Transient Events in Archival VLA Observations of the Galactic Center

    NASA Astrophysics Data System (ADS)

    Chiti, Anirudh; Chatterjee, S.; Wharton, R.; Cordes, J. M.; Lazio, J.; Kaplan, D. L.; Bower, G. C.; Croft, S.

    2014-01-01

    A number of different classes of stars, sub-stellar objects, and stellar remnants exhibit variability at radio wavelengths on time scales ranging from sub-seconds to hours. The direction toward the Galactic center not only has the highest stellar densities in the Galaxy, but also appears to have a range of interstellar scattering properties that may aid in the detection of new, radio-selected transient events. We have examined all archival VLA observations of the Galactic center field from 1985 to 2005 at 5 GHz and 8.4 GHz for a total of 214 hours of integration time, spanning 99 observations at 5 GHz with a typical area of 4.41E-4 square degrees and 116 observations at 8.4 GHz with a typical area of 8E-4 square degrees. We used a pipeline to search for transient events down to the shortest time scales allowed by the data (typically 10 seconds) by generating model-subtracted visibility data for each observation and then imaging the residual visibilities over short time intervals to search for outlier events. We present one radio transient event and at least 7 other promising candidates with significances ranging from 5.6 to 10.2 sigma that have passed all our tests, and discuss the possible source classes for these candidates and the event rate implications. We acknowledge support from the National Science Foundation for this work. Part of this research was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration. The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc.

  4. Numerical simulations of fast transient events in the sun.

    NASA Astrophysics Data System (ADS)

    Casillas-Perez, G. A.; Jeyakumar, S.; Perez-Enriquez, R.

    2016-12-01

    Fast transients are dynamical phenomena that show up as high brightness temperature increments over a duration of less than a second. In the Sun these events have been observed in the radio band in various forms, such as radio spikes for example, often seen accompanying other phenomena like normal radio bursts and solar flares. The study of solar fast radio transients is important to understand the physical processes occurring in the solar corona and its possible relation to other solar phenomena where large amounts of energy are released. In this work, we report a code developed to study the evolution of an electron beam pulse injected into the solar corona. We show the tests to validate the code and some results that have been obtained from the numerical simulations that were carried out using this code.

  5. Transient neurologic event following administration of foam sclerotherapy.

    PubMed

    Malvehy, Mario Albert; Asbjornsen, Cindy

    2017-02-01

    This report describes a complication of symptoms consistent with transient ischemic attack following administration of physician-compounded foam sclerotherapy created with room air. After intravenous administration of 8 cc of foam sclerosant prepared with room air and polidocanol using the Tessari method, an otherwise healthy man experienced transient neurologic changes. Immediately following injection of foam, a dense hemiplegia consistent with interruption of the middle cerebral arterial circulation was observed. The patient's symptoms resolved completely over approximately 30 min with interventions including Trendelenburg positioning and supplemental oxygen via nasal cannula. PCP foam sclerotherapy with room air administered in typical concentrations, preparations, and volumes may result in severe neurologic events in otherwise healthy individuals. Continued investigation into the potential role of product, gas, volume and technique to identify optimal approaches may further refine the consistency and safety of foam sclerotherapy.

  6. Transient Circulation Event near the Deep Ocean Floor.

    PubMed

    Schwartzlose, R A; Isaacs, J D

    1969-08-29

    On 24 January 1968, a transient deep-circulation event was recorded by a triangular array of autonomous current recorders installed 3 meters above the bottom at two of the three positions and at intervals of 3 to 1000 meters above the bottom at the third position in a depth of 3950 meters above the relatively smooth floor of the eastern North Pacific. The event interrupted a 24-hour record of relatively steady but peculiar conditions, lasted for about 1(1/2) hours, and was followed by current directions and speeds that greatly differed from those of the initial period. The event occurred over a volume of the sea of at least 2 kilometers in horizontal dimensions and 1 kilometer thick. Associated with the event were many small clockwise-rotating features extending from 3 to at least 1000 meters above the bottom and a rapidly increasing current velocity at 1000 meters. The event was probably local and may have involved convective motion, internal waves, and the passage of front. Some of the changes in horizontal velocity may have resulted from the combined effects of upwelling and the earth's rotation.

  7. Solar transient events and their importance for coronal heating.

    PubMed

    Doyle, J Gerry; Madjarska, Maria S

    2004-01-01

    Over the last decade, the uninterrupted high resolution coverage of the Sun both from the excellent range of telescopes aboard many spacecrafts and from ground-based instruments has led to a wealth of observations of small-scale dynamic events observed from the chromosphere to the transition region and corona. Since many of these events were observed with different instruments they show different properties from one another. It is suggested that many of these phenomena result from small-scale reconnection events due to the continually evolving magnetic fields as seen at the photospheric level, although waves are thought to play an important heating role as well. Nowadays, there is a general consensus that the key to understanding how the solar plasma is accelerated and heated may well be found in the study of these small-scale dynamic events. Here we give a brief review of the range of observed transient features and suggest that these small-scale events may well have broad implications for the mass and energy balance of the whole upper atmosphere of the Sun and the solar wind.

  8. Vegetation Response to Transient Drought Events in the Upper Midwest

    NASA Astrophysics Data System (ADS)

    Minckley, T.; Booth, R.; Jackson, S.

    2006-12-01

    Two paleohydrological proxies from bog sediments, water level based on testate amoebae assemblages and peat humification, indicate both prolonged and transient drought events over the past 3500 years. High- resolution pollen data for the periods 3000-2200 and 1400-500 cal yr BP from Minden Bog (46.6106N, 82.8347W), Michigan were examined to assess how regional vegetation composition was affected by drought events. Between 3000-2200 cal yr BP, four intervals of multi-decadal drought and one prolonged drought episode were identified. Four of the five dominant arboreal pollen taxa (Betula, Fagus, Quercus and Pinus) do not appear to response to these particular events. In contrast, Tsuga percentages rise at the onset of a prolonged drought ca. 2850 cal yr BP, but decrease rapidly for the duration of this event. Between 1400-500 cal yr BP, five transient droughts and one prolonged dry period were identified. Betula, Pinus, and Tsuga generally increased and Fagus decreased during this period. These trends are punctuated by stepwise changes in pollen percentages associated with the onset and persistence of drought, particularly with the drought starting ca. 1000 cal yr BP. These data suggest that pollen-assemblage responses to climate variation occur across a broad range of scales, involving processes at landscape, community, population, and individual levels. At centennial timescales regional forest composition changes in response to climate variation via demographic processes and altered disturbance regimes. These responses can be rapid if the forcing is large enough. Transient drought events of lower magnitude (e.g., decadal/multidecadal) are accompanied by pollen responses, but these may be linked to changes in pollen productivity at the scale of individual trees across the landscape rather than demographic changes. Tree species differ in their physiological and reproductive responses to drought stress, with some reducing allocations to pollen productivity and others

  9. Sensor Webs: Autonomous Rapid Response to Monitor Transient Science Events

    NASA Technical Reports Server (NTRS)

    Mandl, Dan; Grosvenor, Sandra; Frye, Stu; Sherwood, Robert; Chien, Steve; Davies, Ashley; Cichy, Ben; Ingram, Mary Ann; Langley, John; Miranda, Felix

    2005-01-01

    To better understand how physical phenomena, such as volcanic eruptions, evolve over time, multiple sensor observations over the duration of the event are required. Using sensor web approaches that integrate original detections by in-situ sensors and global-coverage, lower-resolution, on-orbit assets with automated rapid response observations from high resolution sensors, more observations of significant events can be made with increased temporal, spatial, and spectral resolution. This paper describes experiments using Earth Observing 1 (EO-1) along with other space and ground assets to implement progressive mission autonomy to identify, locate and image with high resolution instruments phenomena such as wildfires, volcanoes, floods and ice breakup. The software that plans, schedules and controls the various satellite assets are used to form ad hoc constellations which enable collaborative autonomous image collections triggered by transient phenomena. This software is both flight and ground based and works in concert to run all of the required assets cohesively and includes software that is model-based, artificial intelligence software.

  10. Answering Questions about Complex Events

    DTIC Science & Technology

    2008-12-19

    STRIPS: Fikes and Nilsson 1971) to work in probabilistic models of planning, events and causality ( Astrom 1965; Pearl 2001), employing many... Astrom , K. J. (1965). "Optimal control of Markov decision processes with incomplete state estimation." J1 Math1 Anal1 Applic. 10: 174-205. Barker, K

  11. Transient Events in Archival Very Large Array Observations of the Galactic Center

    NASA Astrophysics Data System (ADS)

    Chiti, Anirudh; Chatterjee, Shami; Wharton, Robert; Cordes, James; Lazio, T. Joseph W.; Kaplan, David L.; Bower, Geoffrey C.; Croft, Steve

    2016-12-01

    The Galactic center has some of the highest stellar densities in the Galaxy and a range of interstellar scattering properties, which may aid in the detection of new radio-selected transient events. Here, we describe a search for radio transients in the Galactic center, using over 200 hr of archival data from the Very Large Array at 5 and 8.4 GHz. Every observation of Sgr A* from 1985 to 2005 has been searched using an automated processing and detection pipeline sensitive to transients with timescales between 30 s and 5 minutes with a typical detection threshold of ˜100 mJy. Eight possible candidates pass tests to filter false-positives from radio-frequency interference, calibration errors, and imaging artifacts. Two events are identified as promising candidates based on the smoothness of their light curves. Despite the high quality of their light curves, these detections remain suspect due to evidence of incomplete subtraction of the complex structure in the Galactic center, and apparent contingency of one detection on reduction routines. Events of this intensity (˜100 mJy) and duration (˜100 s) are not obviously associated with known astrophysical sources, and no counterparts are found in data at other wavelengths. We consider potential sources, including Galactic center pulsars, dwarf stars, sources like GCRT J1745-3009, and bursts from X-ray binaries. None can fully explain the observed transients, suggesting either a new astrophysical source or a subtle imaging artifact. More sensitive multiwavelength studies are necessary to characterize these events, which, if real, occur with a rate of {14}-12+32 {{hr}}-1 {\\deg }-2 in the Galactic center.

  12. Event oriented dictionary learning for complex event detection.

    PubMed

    Yan, Yan; Yang, Yi; Meng, Deyu; Liu, Gaowen; Tong, Wei; Hauptmann, Alexander G; Sebe, Nicu

    2015-06-01

    Complex event detection is a retrieval task with the goal of finding videos of a particular event in a large-scale unconstrained Internet video archive, given example videos and text descriptions. Nowadays, different multimodal fusion schemes of low-level and high-level features are extensively investigated and evaluated for the complex event detection task. However, how to effectively select the high-level semantic meaningful concepts from a large pool to assist complex event detection is rarely studied in the literature. In this paper, we propose a novel strategy to automatically select semantic meaningful concepts for the event detection task based on both the events-kit text descriptions and the concepts high-level feature descriptions. Moreover, we introduce a novel event oriented dictionary representation based on the selected semantic concepts. Toward this goal, we leverage training images (frames) of selected concepts from the semantic indexing dataset with a pool of 346 concepts, into a novel supervised multitask lp -norm dictionary learning framework. Extensive experimental results on TRECVID multimedia event detection dataset demonstrate the efficacy of our proposed method.

  13. Production of Nitrogen Oxides by Laboratory Simulated Transient Luminous Events

    NASA Astrophysics Data System (ADS)

    Peterson, H.; Bailey, M.; Hallett, J.; Beasley, W.

    2007-12-01

    Restoration of the polar stratospheric ozone layer has occurred at rates below those originally expected following reductions in chlorofluorocarbon (CFC) usage. Additional reactions affecting ozone depletion now must also be considered. This research examines nitrogen oxides (NOx) produced in the middle atmosphere by transient luminous events (TLEs), with NOx production in this layer contributing to the loss of stratospheric ozone. In particular, NOx produced by sprites in the mesosphere would be transported to the polar stratosphere via the global meridional circulation and downward diffusion. A pressure-controlled vacuum chamber was used to simulate middle atmosphere pressures, while a power supply and in-chamber electrodes were used to simulate TLEs in the pressure controlled environment. Chemiluminescence NOx analyzers were used to sample NOx produced by the chamber discharges- originally a Monitor Labs Model 8440E, later a Thermo Environment Model 42. Total NOx production for each discharge as well as NOx per ampere of current and NOx per Joule of discharge energy were plotted. Absolute NOx production was greatest for discharge environments with upper tropospheric pressures (100-380 torr), while NOx/J was greatest for discharge environments with stratospheric pressures (around 10 torr). The different production efficiencies in NOx/J as a function of pressure pointed to three different production regimes, each with its own reaction mechanisms: one for tropospheric pressures, one for stratospheric pressures, and one for upper stratospheric to mesospheric pressures (no greater than 1 torr).

  14. Modeling Single Event Transients in Advanced Devices and ICs

    NASA Astrophysics Data System (ADS)

    Artola, L.; Gaillardin, M.; Hubert, G.; Raine, M.; Paillet, P.

    2015-08-01

    The ability for Single Event Transients (SETs) to induce soft errors in Integrated Circuits (ICs) was predicted for the first time by Wallmark and Marcus in the early 60's and was confirmed to be a serious issue thirty years later. In the 90's microelectronic technologies reached the “deep submicron” era, allowing high density ICs working at frequencies faster than hundreds of MHz. This new paradigm changed the status of SETs to become a major source of reliability losses. Huge efforts have thus been made to characterize SETs in microelectronics, either using experiments or by simulation, in order to reveal key factors leading to SET occurrence, propagation and capture in modern ICs. In this context, modeling and simulation are of primary importance to get accurate SET predictions. This paper focuses on modeling SETs in innovative electronic devices which involves modeling steps at different scales, from ionizing particle to circuit response. After a brief review of the state-of-the art of modeling at each scale, this paper will discuss current capabilities and intrinsic limitations of SET modeling, the incoming challenges in advanced devices and ICs, and finally the methodologies to improve SET simulation and prediction for future technologies.

  15. Controlling extreme events on complex networks

    NASA Astrophysics Data System (ADS)

    Chen, Yu-Zhong; Huang, Zi-Gang; Lai, Ying-Cheng

    2014-08-01

    Extreme events, a type of collective behavior in complex networked dynamical systems, often can have catastrophic consequences. To develop effective strategies to control extreme events is of fundamental importance and practical interest. Utilizing transportation dynamics on complex networks as a prototypical setting, we find that making the network ``mobile'' can effectively suppress extreme events. A striking, resonance-like phenomenon is uncovered, where an optimal degree of mobility exists for which the probability of extreme events is minimized. We derive an analytic theory to understand the mechanism of control at a detailed and quantitative level, and validate the theory numerically. Implications of our finding to current areas such as cybersecurity are discussed.

  16. Underlying mechanisms of transient luminous events: a review

    NASA Astrophysics Data System (ADS)

    Surkov, V. V.; Hayakawa, M.

    2012-08-01

    Transient luminous events (TLEs) occasionally observed above a strong thunderstorm system have been the subject of a great deal of research during recent years. The main goal of this review is to introduce readers to recent theories of electrodynamics processes associated with TLEs. We examine the simplest versions of these theories in order to make their physics as transparent as possible. The study is begun with the conventional mechanism for air breakdown at stratospheric and mesospheric altitudes. An electron impact ionization and dissociative attachment to neutrals are discussed. A streamer size and mobility of electrons as a function of altitude in the atmosphere are estimated on the basis of similarity law. An alternative mechanism of air breakdown, runaway electron mechanism, is discussed. In this section we focus on a runaway breakdown field, characteristic length to increase avalanche of runaway electrons and on the role played by fast seed electrons in generation of the runaway breakdown. An effect of thunderclouds charge distribution on initiation of blue jets and gigantic jets is examined. A model in which the blue jet is treated as upward-propagating positive leader with a streamer zone/corona on the top is discussed. Sprite models based on streamer-like mechanism of air breakdown in the presence of atmospheric conductivity are reviewed. To analyze conditions for sprite generation, thunderstorm electric field arising just after positive cloud-to-ground stroke is compared with the thresholds for propagation of positively/negatively charged streamers and with runway breakdown. Our own estimate of tendril's length at the bottom of sprite is obtained to demonstrate that the runaway breakdown can trigger the streamer formation. In conclusion we discuss physical mechanisms of VLF (very low frequency) and ELF (extremely low frequency) phenomena associated with sprites.

  17. Development of transient initiating event frequencies for use in probabilistic risk assessments

    SciTech Connect

    Mackowiak, D.P.; Gentillon, C.D.; Smith, K.L.

    1985-05-01

    Transient initiating event frequencies are an essential input to the analysis process of a nuclear power plant probabilistic risk assessment. These frequencies describe events causing or requiring scrams. This report documents an effort to validate and update from other sources a computer-based data file developed by the Electric Power Research Institute (EPRI) describing such events at 52 United States commercial nuclear power plants. Operating information from the United States Nuclear Regulatory Commission on 24 additional plants from their date of commercial operation has been combined with the EPRI data, and the entire data base has been updated to add 1980 through 1983 events for all 76 plants. The validity of the EPRI data and data analysis methodology and the adequacy of the EPRI transient categories are examined. New transient initiating event frequencies are derived from the expanded data base using the EPRI transient categories and data display methods. Upper bounds for these frequencies are also provided. Additional analyses explore changes in the dominant transients, changes in transient outage times and their impact on plant operation, and the effects of power level and scheduled scrams on transient event frequencies. A more rigorous data analysis methodology is developed to encourage further refinement of the transient initiating event frequencies derived herein. Updating the transient event data base resulted in approx.2400 events being added to EPRI's approx.3000-event data file. The resulting frequency estimates were in most cases lower than those reported by EPRI, but no significant order-of-magnitude changes were noted. The average number of transients per year for the combined data base is 8.5 for pressurized water reactors and 7.4 for boiling water reactors.

  18. Effects of Solar Activities on the Transient Luminous Events

    NASA Astrophysics Data System (ADS)

    Wu, Y.; Williams, E.; Chou, J.; Lee, L.; Huang, S.; Chang, S.; Chen, A. B.; Kuo, C.; Su, H.; Hsu, R.; Frey, H. U.; Takahashi, Y.; Lee, L.

    2013-12-01

    The Imager of Sprite and Upper Atmosphere Lightning (ISUAL) onboard the Formosat-2 was launched in May 2004; since then, it has continuously observed transient luminous events (TLEs) within the +/-60 degree of latitude for nearly 10 years. Due to ISUAL's long-term observations, the possible correlation between the TLE and the solar activity can be explored. Among the ISUAL TLEs, elves, which occur at the mesospheric altitude ~90 km and are caused by the heating incurred by the lightning-launched electromagnetic pulse of the lower ionosphere boundary are the most numerous and are the most suitable for this type of study. In previous studies, the elve distribution has proved to be a good surrogate for the lightning with exceptional peak current globally. ISUAL records the occurrence time and the height and location of elves, and the spectral emission intensities at six different band pass including the FUV N2 Lyman-Birge-Hopfield (LBH) band, which is a dominant emission in elves. The LBH intensity not only reflects the peak current of parent lightning, but may also represent the solar-activity-driven-lighting's perturbation to the ionosphere. In this study, we first examine whether the 11-year solar cycle affects the elve activity and altitude by analyzing the elve occurrence rates and heights in different latitudinal regions. To avoid the climatological and instrumental biases in the elve observations, the effects arising from the ENSO and moonlight must be carefully eliminated. Besides, we will discuss the elve variation in shorter time scale due to strong and sudden change of solar activity. Since the ion density of the mesosphere at mid-latitude may be significantly altered during/after a strong corona mass ejection (CME).Furthermore, it has been proven that the changes in the solar X-ray flux dominate the variations in the conductivity profile within the upper characteristic ELF layer (the 90-100km portion of the E-region). we will compare the variation of

  19. Applying Machine Learning Tools to the Identification of Foreshock Transient Events

    NASA Astrophysics Data System (ADS)

    Beyene, F.; Murr, D.

    2015-12-01

    Our previous research attempted to establish the relationship between foreshock transient events and transients in the ionosphere observed with ground magnetometers. This earlier work relied on foreshock transient event lists that were generated by a visual survey of the THEMIS data near the bowshock/foreshock. Our aim is to extend our earlier work, and the overall understanding of foreshock transients, by employing machine learning tools to identify foreshock transient events. Successful application of these tools would allow use to survey much more data. We first present results of automated classification of THEMIS data into the three primary regions of solar wind, magnetosheath, and magnetosphere. We then present our initial results of training an SVM classifier using the human generated event list and applying it to a more extensive data set.

  20. Controlling extreme events on complex networks

    PubMed Central

    Chen, Yu-Zhong; Huang, Zi-Gang; Lai, Ying-Cheng

    2014-01-01

    Extreme events, a type of collective behavior in complex networked dynamical systems, often can have catastrophic consequences. To develop effective strategies to control extreme events is of fundamental importance and practical interest. Utilizing transportation dynamics on complex networks as a prototypical setting, we find that making the network “mobile” can effectively suppress extreme events. A striking, resonance-like phenomenon is uncovered, where an optimal degree of mobility exists for which the probability of extreme events is minimized. We derive an analytic theory to understand the mechanism of control at a detailed and quantitative level, and validate the theory numerically. Implications of our finding to current areas such as cybersecurity are discussed. PMID:25131344

  1. Transient photocyclization in ruthenium(ii) polypyridine complexes of indolamines.

    PubMed

    Carrone, G; Zayat, L; Slep, L D; Etchenique, R

    2017-01-18

    Ruthenium polypyridine complexes have proved to be useful caging groups for visible-light photodelivery of biomolecules. In most photoreactions, one ligand is expelled upon irradiation, yielding ruthenium mono-aqua complexes and no other photoproduct. In this work we show that a long-lived transient photoproduct is generated when the ruthenium complexes involve indolamines. The spatial conformation of this species is compatible with a cyclic structure that contains both the amine and the normally non-coordinating aromatic ring coordinated to the ruthenium center.

  2. Transient luminous events above two mesoscale convective systems

    NASA Astrophysics Data System (ADS)

    Lang, Timothy; Rutledge, Steve; Lyons, Walt; Cummer, Steve; Li, Jingbo; Macgorman, Don

    2010-05-01

    Two warm-season mesoscale convective systems (MCSs) were analyzed with respect to production of transient luminous events (TLEs), mainly sprites. Sprites were documented over the lightning mapping array (LMA) network in Oklahoma, USA, using highly sensitive optical cameras operated at Yucca Ridge in Ft. Collins, Colorado, as part of our Sprites 2007 field campaign. Information about charge moment changes in lightning flashes was obtained by the National Charge Moment Change Network (CMCN). Cloud-to-ground lightning data were obtained from the National Lightning Detection Network (NLDN). The 20 June 2007 symmetric MCS produced 282 observed TLEs over a 4-h period, during which time the storm's intense convection weakened and its stratiform region strengthened. In contrast to previous sprite studies, the stratiform charge layer involved in producing the TLE-parent positive cloud-to-ground (+CG) lightning flash was situated at upper levels as opposed to near the melting level. This layer was physically connected to an even higher upper-level convective positive charge region via a downward-sloping pathway. The average altitude discharged by TLE-parent flashes during TLE activity was 8.2 km above mean sea level (MSL; -25 °C). The 9 May 2007 asymmetric MCS produced 25 observed TLEs over a 2-h period, during which the storm's convection rapidly weakened before recovering later. The 9 May storm best fit the conventional model of low-altitude positive charge playing the dominant role in sprite production; however, the average altitude discharged during the TLE phase of flashes still was higher than the melting level: 6.1 km MSL (-15 °C). The average TLE-parent +CG flash in the symmetric 20 June case initiated at higher altitude, discharged a substantially larger area, had a larger peak current, and tapped positive charge at higher altitude compared to the asymmetric 9 May case. Analysis of full charge moment change (CMC) data from TLE-parent +CGs in these two cases

  3. Transient Evoked Potential in a Critical Event Detection Task.

    DTIC Science & Technology

    1984-02-01

    Vigilance and Discrimination: A Reassessment," Science, 164:326-328, 1969. 38. Fabiani , Monica and others. "Individual Differences in the von Restorff...implies that events which elicit a P300 are more likely to be remembered than events which do not 2-23 .... . . ... invoke a P300 (15:507-510). Fabiani

  4. Using GPS to Rapidly Detect and Model Earthquakes and Transient Deformation Events

    NASA Astrophysics Data System (ADS)

    Crowell, Brendan W.

    The rapid modeling and detection of earthquakes and transient deformation is a problem of extreme societal importance for earthquake early warning and rapid hazard response. To date, GPS data is not used in earthquake early warning or rapid source modeling even in Japan or California where the most extensive geophysical networks exist. This dissertation focuses on creating algorithms for automated modeling of earthquakes and transient slip events using GPS data in the western United States and Japan. First, I focus on the creation and use of high-rate GPS and combined seismogeodetic data for applications in earthquake early warning and rapid slip inversions. Leveraging data from earthquakes in Japan and southern California, I demonstrate that an accurate magnitude estimate can be made within seconds using P wave displacement scaling, and that a heterogeneous static slip model can be generated within 2-3 minutes. The preliminary source characterization is sufficiently robust to independently confirm the extent of fault slip used for rapid assessment of strong ground motions and improved tsunami warning in subduction zone environments. Secondly, I investigate the automated detection of transient slow slip events in Cascadia using daily positional estimates from GPS. Proper geodetic characterization of transient deformation is necessary for studies of regional interseismic, coseismic and postseismic tectonics, and miscalculations can affect our understanding of the regional stress field. I utilize the relative strength index (RSI) from financial forecasting to create a complete record of slow slip from continuous GPS stations in the Cascadia subduction zone between 1996 and 2012. I create a complete history of slow slip across the Cascadia subduction zone, fully characterizing the timing, progression, and magnitude of events. Finally, using a combination of continuous and campaign GPS measurements, I characterize the amount of extension, shear and subsidence in the

  5. THEMIS Observations of Unusual Bow Shock Motion, Attending a Transient Magnetospheric Event

    NASA Technical Reports Server (NTRS)

    Korotova, Galina; Sibeck, David; Omidi, N.; Angelopoulos, V.

    2013-01-01

    We present a multipoint case study of solar wind and magnetospheric observations during a transient magnetospheric compression at 2319 UT on October 15, 2008. We use high-time resolution magnetic field and plasma data from the THEMIS and GOES-11/12 spacecraft to show that this transient event corresponded to an abrupt rotation in the IMF orientation, a change in the location of the foreshock, and transient outward bow shock motion. We employ results from a global hybrid code model to reconcile the observations indicating transient inward magnetopause motion with the outward bow shock motion.

  6. A series of transient slip events on Kilauea volcano, Hawaii.

    NASA Astrophysics Data System (ADS)

    Desmarais, E. K.; Segall, P.; Miklius, A.; Cervelli, P.

    2005-12-01

    Deformation on Kilauea volcano, Hawaii is monitored by a network of continuously recording GPS stations, among other methds. Since its installation in 1996, the GPS network has detected four spatially coherent accelerations on Kilauea's south flank that are not caused by either intrusions or earthquakes. These events, each lasting several hours to two days, occurred in September 1998, November 2000, July 2003, and January 2005. Previously, Cervelli et al., (Nature, 2002) interpreted the 2000 event as a silent earthquake due to slip on a sub-horizontal fault beneath Kilauea's south flank. We inverted the cumulative displacements ( less than 2 cm) using a simulated annealing algorithm for each event and found similarly sized, near horizontal, uniform slip source locations for all four events at depths of ~6 km. The estimated slip magnitudes are between 9 and 15 cm, with the upper block moving seaward. The 2005 event is the largest detected to date. Volcano-tectonic (VT) earthquakes on the south flank of Kilauea are typically restricted to the volume between the East Rift Zone and the Hilina and Poliokeawe Palis. Seismicity in this volume increased significantly during the silent events at depths of 5-10 km. However, all of the VT earthquakes were small ( less than M3) and their cumulative moment does not account for the moment released during the silent slip events. We are currently examining seismic waveform data for evidence of other signals, such as non-volcanic tremor, that might be associated with the slip events. To determine the exact onset and duration of the silent earthquakes, we invert for slip as a function of time directly from raw GPS phase and pseudorange observations. The November 2000 silent earthquake was preceded 9 days earlier by nearly 1 m of rainfall, which was speculated in Cervelli et al., (Nature, 2002) to have reduced fault stability through surface loading or pore pressure increase. In contrast, both the 2003 and 2005 events occurred

  7. Acoustic classification of battlefield transient events using wavelet sub-band features

    NASA Astrophysics Data System (ADS)

    Azimi-Sadjadi, M. R.; Jiang, Y.; Srinivasan, S.

    2007-04-01

    Detection, localization and classification of battlefield acoustic transient events are of great importance especially for military operations in urban terrain (MOUT). Generally, there can be a wide variety of battlefield acoustic transient events such as different caliber gunshots, artillery fires, and mortar fires. The discrimination of different types of transient sources is plagued by highly non-stationary nature of these signals, which makes the extraction of representative features a challenging task. This is compounded by the variations in the environmental and operating conditions and existence of a wide range of possible interference. This paper presents new approaches for transient signal estimation and feature extraction from acoustic signatures collected by several distributed sensor nodes. A maximum likelihood (ML)-based method is developed to remove noise/interference and fading effects and restore the acoustic transient signals. The estimated transient signals are then represented using wavelets. The multi-resolution property of the wavelets allows for capturing fine details in the transient signals that can be utilized to successfully classify them. Wavelet sub-band higher order moments and energy-based features are used to characterize the transient signals. The discrimination ability of the subband features for transient signal classification has been demonstrated on several different caliber gunshots. Important findings and observations on these results are also presented.

  8. GS-TEC: the Gaia spectrophotometry transient events classifier

    NASA Astrophysics Data System (ADS)

    Blagorodnova, Nadejda; Koposov, Sergey E.; Wyrzykowski, Łukasz; Irwin, Mike; Walton, Nicholas A.

    2014-07-01

    We present an algorithm for classifying the nearby transient objects detected by the Gaia satellite. The algorithm will use the low-resolution spectra from the blue and red spectrophotometers on board the satellite. Taking a Bayesian approach, we model the spectra using the newly constructed reference spectral library and literature-driven priors. We find that for magnitudes brighter than 19 in Gaia G magnitude, around 75 per cent of the transients will be robustly classified. The efficiency of the algorithm for Type Ia supernovae (SNe I) is higher than 80 per cent for magnitudes G ≤ 18, dropping to approximately 60 per cent at magnitude G = 19. For SNe II, the efficiency varies from 75 to 60 per cent for G ≤ 18, falling to 50 per cent at G = 19. The purity of our classifier is around 95 per cent for SNe I for all magnitudes. For SNe II, it is over 90 per cent for objects with G ≤ 19. GS-TEC also estimates the redshifts with errors of σz ≤ 0.01 and epochs with uncertainties σt ≃ 13 and 32 d for SNe I and SNe II, respectively. GS-TEC has been designed to be used on partially calibrated Gaia data. However, the concept could be extended to other kinds of low-resolution spectra classification for ongoing surveys.

  9. A very long-term transient event preceding the 2011 Tohoku earthquake.

    PubMed

    Yokota, Yusuke; Koketsu, Kazuki

    2015-01-06

    Geodetic transients have been observed in various subduction zones. The 2011 Tohoku earthquake occurred in one of the most active subduction zones globally, the Japan Trench subduction zone (JTSZ). However, no geodetic transient (except afterslip and so on) had been reported in the JTSZ before the Tohoku earthquake. Here we show that a large transient event, with duration longer than any reported previously, occurred in the JTSZ preceding the Tohoku earthquake. We calculate tectonic deformations at Global Positioning System stations along the JTSZ by removing the effects of nearby M(w) 6-8 earthquakes. We identify temporal changes in these deformations, deriving 9-year deviation records from regular deformations due to slip deficit at the plate boundary. We perform an inversion of the deviations to obtain the source model of their root event. The relationship between the obtained transient event and Tohoku earthquake is shown through Coulomb stress change and seismic supercycle simulation.

  10. Transient vortex events in the initial value problem for turbulence.

    PubMed

    Holm, D D; Kerr, Robert

    2002-06-17

    A vorticity surge event that could be a paradigm for a wide class of bursting events in turbulence is studied. The coherent mechanism is characterized by locally transverse vortex configurations that are intrinsically helical in both physical and Fourier space when there is a peak of the maximum vorticity parallel omega parallel(infinity)(t). At no time are nonhelical, antiparallel vorticity elements observed. This event precedes the appearance of the traditional signatures of an energy cascade such as strong growth of the dissipation, spectra approaching -5/3, and strongly Beltramized vortex tubes. Comparing how different large-eddy simulations reproduce these properties demonstrates the importance of properly modeling nonlinear transport of both energy and helicity.

  11. Biomagnetic localization from transient quasi-static events

    SciTech Connect

    Mosher, J.C.; Leahy, R.M.; Lewis, P.S. University of Southern California, Los Angeles, CA . Signal and Image Processing Inst.)

    1993-01-01

    Sensory stimuli, such as auditory, visual, or somatosensory, evoke neural responses in very localized regions of the brain. A SQUID biomagnetometer can measure the very weak fields that are generated outside of the head by this response. A simple source and head model of current dipoles inside a conducting sphere is typically used to interpret these magnetic field measurements or magnetoencephalogram (MEG). Locating dipole sources using data recorded from an array of biomagnetic sensors is distinguished from conventional array source localization techniques by the quasi-static transient nature of the data. Here, the basic MEG model is reviewed, then a localization example is given to motivate the need for partitioning the data to improve estimator performance. Tune-eigenspectrum analysis is introduced as a means of partitioning and interpreting spatio-temporal biomagnetic data. Examples using both simulated and somatosensory data are presented.

  12. Biomagnetic localization from transient quasi-static events

    SciTech Connect

    Mosher, J.C.; Leahy, R.M.; Lewis, P.S. |

    1993-02-01

    Sensory stimuli, such as auditory, visual, or somatosensory, evoke neural responses in very localized regions of the brain. A SQUID biomagnetometer can measure the very weak fields that are generated outside of the head by this response. A simple source and head model of current dipoles inside a conducting sphere is typically used to interpret these magnetic field measurements or magnetoencephalogram (MEG). Locating dipole sources using data recorded from an array of biomagnetic sensors is distinguished from conventional array source localization techniques by the quasi-static transient nature of the data. Here, the basic MEG model is reviewed, then a localization example is given to motivate the need for partitioning the data to improve estimator performance. Tune-eigenspectrum analysis is introduced as a means of partitioning and interpreting spatio-temporal biomagnetic data. Examples using both simulated and somatosensory data are presented.

  13. Peculiar transient events in the Schumann resonance band and their possible explanation

    NASA Astrophysics Data System (ADS)

    Ondrásková, Adriena; Bór, József; S[Breve]Evcík, Sebastián; Kostecký, Pavel; Rosenberg, Ladislav

    2008-04-01

    Superimposed on the continuous Schumann resonance (SR) background in the extremely low frequency (ELF) band, transient signals (e.g. bursts) can be observed, which originate from intense lightning discharges occurring at different locations on the globe. From the many transients that were observed at the Astronomical and Geophysical Observatory (AGO) of Comenius University near Modra, western Slovakia, in the vertical electric field component mainly during May and June of 2006, a peculiar group of events could be recognized. According to the waveform analysis, these peculiar events in most cases consist of two overlapping transients with a characteristic time difference of 0.13-0.15 s between the onsets. On the other hand, the spectrum of these peculiar transients showed discernible SR peaks for higher modes as well (n>7). The same events could be found in the records of the Széchenyi István Geophysical Observatory of the Geodetic and Geophysical Research Institute of the Hungarian Academy of Sciences near Nagycenk, Hungary (NCK). The natural origin of the peculiar events was verified from the NCK data and the source location was determined from the second transient. The results suggest that the two consecutive transients originated in the same thunderstorm. Furthermore, the phase spectrum analysis indicates that the sources have coherently excited the Earth-ionosphere cavity. These findings seem to support the idea that electromagnetic waves orbiting the Earth might trigger lightning discharges. The possibility that electromagnetic waves may trigger discharges was first considered by Nikola Tesla.

  14. First Light with the NRAO Transient Event Capture Hardware

    NASA Astrophysics Data System (ADS)

    Langston, Glen; Rumberg, B.; Brandt, P.

    2007-12-01

    The design, implementation and testing of the first NRAO Event Capture data acquisition system is presented. The NRAO in Green Bank is developing a set of new data acquisition systems based on the U.C. Berkeley CASPER IBOB/ADC/BEE2 hardware. We describe the hardware configuration and initial experiences with the development system. We present first astronomical tests of the Event Capture system, using the 43m telescope (140ft). These observations were carried out at 900 MHz. The observations were made on 2007 July 8 and 9 towards the Crab pulsar, the galactic center, the Moon and two test observations while the 43m was pointed at Zenith (straight up). The Event Capture is one of several on-going FPGA based data acquisition projects being implemented for the Robert C. Byrd Green Bank Telescope (GBT) and for the 43m telescopes. The NRAO Configurable Instrument Collaboration for Agile Data Acquisition (CICADA) program is described at: http://wikio.nrao.edu/bin/view/CICADA

  15. Position-gram - A Visual Method for Detecting Transient Events in Continuous GPS Time Series

    NASA Astrophysics Data System (ADS)

    Jiang, Y.; Wdowinski, S.

    2008-12-01

    Continuous Global Positioning System (CGPS) time series provide excellent observations for detecting crustal deformation at various length and time-scales. With the increasing precision and length of the time series, new modes of deformation, such as slow slip events and sub-continental scale changes in crustal velocities, can be detected. However, non-tectonic surface movements and measurement noise limit our ability to detect and quantify tectonic-induced transient deformation. Two common methods for reducing noise level in CGPS time series, spatial filtering and periodic seasonal fitting, significantly improve the secular tectonic signal, but fail when transient deformation events are embedded in the time series. We developed a new visually-based method for detecting transient events in CGPS time series. The development was inspired by wavelet analysis presentations that use color to present quantitative information about relationships between time and frequency domains. Here we explore the relationship between time and space domains. The displacement information is color coded according to spline fitting of each time series. This 3-D information (time, space, and displacement in color) allows easy detection of spatio-temporal patterns, which can serve as indicators for transient deformation events. We tested the new method with CGPS time series from three regions with different spatial scales: the Pacific Northwest, Southern California, and the entire continental US. The Pacific Northwest study confirmed that our proposed methodology is capable of detecting transient events and mapping their lateral distribution. The Southern California study detected a new transient event near the intersection of the San Andreas and San Jacinto faults, far from any known creeping fault segments. Finally the continental scale analysis revealed regionally correlated crustal movements in the Basin and Range and California, but uncorrelated with sites in eastern US. Such signal

  16. Summary of the CTS Transient Event Counter data after one year of operation. [Communication Technology Satellite

    NASA Technical Reports Server (NTRS)

    Stevens, N. J.; Klinect, V. W.; Gore, J. V.

    1977-01-01

    The environmental charging of satellite surfaces during geomagnetic substorms is the apparent cause of a significant number of anomalous events occurring on geosynchronous satellites since the early 1970's. Electromagnetic pulses produced in connection with the differential charging of insulators can couple into the spacecraft harness and cause electronic switching anomalies. An investigation conducted to determine the response of the spacecraft surfaces to substorm particle fluxes makes use of a harness transient detector. The harness transient detector, called the Transient Event Counter (TEC) was built and integrated into the Canadian-American Communications Technology Satellite (CTS). A description of the TEC and its operational characteristics is given and the obtained data are discussed. The data show that the satellite surfaces appear to be charged to the point that discharges occur and that the discharge-induced transients couple into the wire harnesses.

  17. Preliminary report on the CTS transient event counter performance through the 1976 spring eclipse season

    NASA Technical Reports Server (NTRS)

    Stevens, N. J.; Lovell, R. R.; Klinect, V. W.

    1977-01-01

    The transient event counter is described, defining its operational characteristics, and presenting the preliminary results obtained through the first 90 days of operation including the Spring 1976 eclipse season. The results show that the CTS was charged to the point where discharges have occurred. The discharge induced transients have not caused any anomalous events in spacecraft operation. The data indicate that discharges can occur at any time during the day without preference to any local time quadrant. The number of discharges occurring in the 1 sec sample interval are greater than anticipated.

  18. Multi-wavelength Observations of a Subarcsecond Penumbral Transient Brightening Event

    NASA Astrophysics Data System (ADS)

    Bai, X. Y.; Su, J. T.; Cao, W. D.; Liu, S. Q.; Deng, Y. Y.; Priya, T. G.

    2016-05-01

    We report a subarcsecond penumbral transient brightening event with the high-spatial resolution observations from the 1.6 m New Solar Telescope (NST), Interface Region Imaging Spectrograph (IRIS), and the Solar Dynamics Observatory. The transient brightening, whose thermal energy is in the range of nanoflares, has signatures in the chromosphere, the transient region, and the corona. NST's Hα channel reveals the fine structure of the event with a width as narrow as 101 km (0.″14), which is much smaller than the width from the previous observation. The transient brightening lasts for about 3 minutes. It is associated with a redshift of about 17 km s-1, found in the Si iv 1402.77 Å line and exhibits an inward motion to the umbra with a speed of 87 km s-1. The small-scale energy released from the event has a multi-temperature component. Spectral analysis of the brightening region from IRIS shows that not only the transition region lines such as Si iv 1402.77 Å and C ii 1334.53 Å, but also the chromospheric Mg ii k 2796.35 Å line are significantly enhanced and broadened. In addition, the event can be found in all the extreme-ultraviolet passbands of the Atmospheric Imaging Assembly and the derived differential emission measure profile increases between 4 and 15 MK (or 6.6 ≤ log T ≤ 7.2) in the transient brightening phase. It is possible that the penumbral transient brightening event is caused by magnetic reconnection.

  19. Earth Crossing Asteroid Characterization by Transient Tidal Events

    NASA Astrophysics Data System (ADS)

    Movshovitz, N.; Asphaug, E. I.

    2011-12-01

    Most, if not all asteroids larger than a few hundred meters in diameter are rubble-piles - aggregates of small fragments, held together by self-gravity with virtually no tensile strength. These strenghless bodies are, ironically, very resistant to disruption by collisions, as density discontinuities in their interiors make it impossible for a shock front to propagate far from the impact point. Rubble-piles are, however, very susceptible to disruption by tidal forces. An Earth-Crossing asteroid (ECA) will experience a strong tidal force for a relatively short time, when its orbit brings it deep enough in the Earth's gravitational field. Before there is an asteroid collision with the Earth, we are likely to observe a number of tidal collisions - that is, events which cause observable changes to the asteroid. In addition, new high-resolution maps of the Moon by HiRISE record clear imprints of tidally disrupted asteroids (V. Bray, pers. comm.) So there are and will be data whereby we can understand the bulk asteroid geophysical properties that are so notoriously difficult (and expensive) to measure. Analytical expressions exist for the minimum circular orbit at which a fluid body can retain an equilibrium shape; this is the classic Roche limit. Similar expressions exist for ideal parabolic encounters by non-rotating liquid spheres (Sridhar and Tremaine, 1992). But a rubble-pile ECA will not behave like a fluid body; inter-particle forces and dilatation can prevent it from deforming. Every asteroid tidal encounter with the Earth is unique, so we need good models with the best physics, capable of exploring a wide parameter space. Richardson et al. (1998) explored the sensitivity of tidal disruption of Earth-crossing rubble-piles to the orbit periapse, encounter velocity, spin period, and deviation from sphericity; and found all four highly important in determining the extent of disruption of the progenitor body. They used an N-body code with energy dissipating collisions

  20. Interplanetary magnetic field orientation for transient events in the outer magnetosphere

    NASA Technical Reports Server (NTRS)

    Sibeck, D. G.; Newell, P. T.

    1995-01-01

    It is generally believed that flux transfer events (FTEs) in the outer dayside magneosphere, usually identified by transient (approximately 1 min) bipolar magneitc field perturbations in the direction normal to the nominal magnetopause, occur when the magnetosheath magetic field has a southward component. We compare the results of three methods for determining the magnetosheath magnetic field orientationat the times of previously identified UKS/IRM events: (1) the average magnetosheath magnetic field orientation in the 30-min period adjacent to the nearest magnetopause crossing, (2) the magnetosheath magnetic field orientation observed just outside the magnetopause, and (3) the lagged interplanetary magnetic field (IMF) orientation at the time of the transient events. Whereas the results of method 2 indicate that the events tend to occur for a southward magnetosheath magnetic field, the results of methods 1 and 3 show no such tnedency. The fact that the three methods yield significantly diffeent results emphasizes the need for caution in future studies.

  1. Preliminary report on the CTS transient event counter performance through the 1976 spring eclipse season

    NASA Technical Reports Server (NTRS)

    Stevens, N. J.; Levell, R. R.; Klinect, V. W.

    1976-01-01

    The transient event counter (TEC), senses and counts transients having a voltage rise of greater than five volts in three separate wire harnesses: the attitude control harness, the solar array instrumentation harness and the solar array power harness. The operational characteristics of TEC are defined and the preliminary results obtained through the first 90 days of operation including the spring 1976 eclipse season are presented. The results show that the Communications Technology Satellite was charged to the point where discharges occurred. The discharge induced transients did not cause any anomalous events in spacecraft operation. The data indicate that discharges can occur at any time during the day without preference to any local time quadrant. The number of discharges occurring in the one second sample interval are greater than anticipated. The compilation and review of the data is continuing.

  2. LIMITS ON THE EVENT RATES OF FAST RADIO TRANSIENTS FROM THE V-FASTR EXPERIMENT

    SciTech Connect

    Wayth, Randall B.; Tingay, Steven J.; Deller, Adam T.; Brisken, Walter F.; Thompson, David R.; Wagstaff, Kiri L.; Majid, Walid A.

    2012-07-10

    We present the first results from the V-FASTR experiment, a commensal search for fast transient radio bursts using the Very Long Baseline Array (VLBA). V-FASTR is unique in that the widely spaced VLBA antennas provide a discriminant against non-astronomical signals and a mechanism for the localization and identification of events that is not possible with single dishes or short baseline interferometers. Thus, far V-FASTR has accumulated over 1300 hr of observation time with the VLBA, between 90 cm and 3 mm wavelength (327 MHz-86 GHz), providing the first limits on fast transient event rates at high radio frequencies (>1.4 GHz). V-FASTR has blindly detected bright individual pulses from seven known pulsars but has not detected any single-pulse events that would indicate high-redshift impulsive bursts of radio emission. At 1.4 GHz, V-FASTR puts limits on fast transient event rates comparable with the PALFA survey at the Arecibo telescope, but generally at lower sensitivities, and comparable to the 'fly's eye' survey at the Allen Telescope Array, but with less sky coverage. We also illustrate the likely performance of the Phase 1 SKA dish array for an incoherent fast transient search fashioned on V-FASTR.

  3. Extra-galactic high-energy transients: event rate density and luminosity function

    NASA Astrophysics Data System (ADS)

    Sun, Hui; Zhang, Bing; Li, Zhuo

    2015-08-01

    Several types of extra-galactic high-energy transients have been discovered, which include high-luminosity and low-luminosity long-duration gamma-ray bursts (GRBs), short-duration GRBs, supernova shock breakouts (SBOs), and tidal disruption events (TDEs) without or with a relativistic jet. In this paper, we apply a unified method to systematically study the reshift-dependent event rate densities and luminosity functions of these extra-galactic high-energy transients. We consider star formation history as the tracer of the redshift distribution for long GRBs and SBOs. For short GRBs, we consider the compact star merger model to introduce several possible merger delay time distribution models. For TDEs, we consider the mass distribution of supermassive black holes as a function of redshift. We derive some empirical formulae for the redshift-dependent event rate density for different types of transients. Based on the observed events, we derive the local specific event rate density, ρ0,L ∝ dρ0/dL for each type of transient, which represents its luminosity function. All the transients are consistent with having a single power law luminosity function, except the high luminosity long GRBs (HL-lGRBs), whose luminosity function can be well described by a broken power law. The total event rate density for a particular transient depends on the luminosity threshold, and we obtain the following values in units of Gpc-3 yr-1: 2.82^{+0.41}_{-0.36} for HL-lGRBs above 4×1049 erg s-1 218^{+130}_{-86} for low luminosity long GRBs above 6×1046 erg s-1 3.18^{+0.88}_{-0.70}, 2.87^{+0.80}_{-0.64}, and 6.25^{+1.73}_{-1.38} above 5×1049 erg s-1 for short GRBs with three different merger delay models (Gaussian, log-normal, and power law); 2.0^{+2.6}_{-1.3}×104 above 9×1043 erg s-1 for SBOs, 3.0^{+1.0}_{-0.8}×105 for normal TDEs above 1042 erg s-1 and 6.2^{+8.2}_{-4.0} above 3×1047 erg s-1for TDE jets as discovered by Swift. Intriguingly, the global specific event rate densities

  4. Prospects for observations of transient UV Events with the TAUVEX UV observatory

    NASA Astrophysics Data System (ADS)

    Safonova, Margarita; Sivaram, C.; Murthy, Jayant

    2008-11-01

    Transient events have posed special problems in astronomy because of the intrinsic difficulty of their detection, and a new class of observatories such as the Pan-STARRS and LSST are coming up specifically to observe these energetic events. In this paper we discuss the UV transient events from two specific sources, such as possible collisions in extrasolar planetary systems and M dwarf flares, to find the probability of their detection by space UV observatories, in particular, by the Tel Aviv University Explorer (TAUVEX). TAUVEX is an UV imaging experiment that will image large parts of the sky in the wavelength region between 1200 and 3500 Å. TAUVEX is a collaborative effort between the Indian Institute of Astrophysics (IIA) and Tel Aviv University, and is scheduled for an early-2009 launch with at least three years of operations. The scientific instrument has been fabricated at El-Op in Israel, with the satellite interfaces, launch and flight operations provided by the Indian Space Research Organization (ISRO). The ground-based software development is the responsibility of the IIA while other aspects of the mission are the joint responsibility of IIA and Tel Aviv University. TAUVEX Science Team (TST) have created a coherent observing program to address several key science objectives, one of them is a program to study short-scale UV transient events. We have estimated that in one year of TAUVEX observations we can expect about 90 350 short-scale transient events. Because we obtain real-time telemetry with TAUVEX, we will be able to catch transients early in their evolution and to alert other observatories. We also present a description of TAUVEX mission, including instrument design and its estimated performance.

  5. Extragalactic High-energy Transients: Event Rate Densities and Luminosity Functions

    NASA Astrophysics Data System (ADS)

    Sun, Hui; Zhang, Bing; Li, Zhuo

    2015-10-01

    Several types of extragalactic high-energy transients have been discovered, which include high-luminosity and low-luminosity long-duration gamma-ray bursts (GRBs), short-duration GRBs, supernova shock breakouts (SBOs), and tidal disruption events (TDEs) without or with an associated relativistic jet. In this paper, we apply a unified method to systematically study the redshift-dependent event rate densities and the global luminosity functions (GLFs; ignoring redshift evolution) of these transients. We introduce some empirical formulae for the redshift-dependent event rate densities for different types of transients and derive the local specific event rate density, which also represents its GLF. Long GRBs (LGRBs) have a large enough sample to reveal features in the GLF, which is best charaterized as a triple power law (PL). All the other transients are consistent with having a single-power-law (SPL) LF. The total event rate density depends on the minimum luminosity, and we obtain the following values in units of Gpc-3 yr-1: {0.8}-0.1+0.1 for high-luminosity LGRBs above 1050 erg s-1 {164}-65+98 for low-luminosity LGRBs above 5 × 1046 erg s-1 {1.3}-0.3+0.4, {1.2}-0.3+0.4, and {3.3}-0.8+1.0 above 1050 erg s-1 for short GRBs with three different merger delay models (Gaussian, lognormal, and PL); {1.9}-1.2+2.4× {10}4 above 1044 erg s-1 for SBOs, {4.8}-2.1+3.2× {10}2 for normal TDEs above 1044 erg s-1 and {0.03}-0.02+0.04 above 1048 erg s-1 for TDE jets as discovered by Swift. Intriguingly, the GLFs of different kinds of transients, which cover over 12 orders of magnitude, are consistent with an SPL with an index of -1.6.

  6. Experimental Investigation of Bearing Slip in a Wind Turbine Gearbox During a Transient Grid Loss Event

    SciTech Connect

    Helsen, Jan; Guo, Yi; Keller, Jonathan; Guillaume, Patrick

    2016-12-01

    This work investigates the behaviour of the high speed stage of a wind turbine gearbox during a transient grid loss event. Dynamometer testing on a full scale wind turbine nacelle is used. A combination of external and internal gearbox measurements is analysed. Particular focus is on the characterization of the high speed shaft tapered roller bearing slip behaviour. This slipping behaviour is linked to dynamic events by many researchers and described as potential bearing failure initiator. However only limited full scale dynamic testing is documented. Strain gauge bridges in grooves along the circumference of the outer ring are used to characterize the bearing behaviour in detail. It is shown that during the transient event the high speed shaft experiences a combined torsional and bending deformation. These unfavourable loading conditions induce roller slip in the bearings during the torque reversals indicating the potential of the applied load case to go beyond the preload of the tapered roller bearing.

  7. CONNECTING FLARES AND TRANSIENT MASS-LOSS EVENTS IN MAGNETICALLY ACTIVE STARS

    SciTech Connect

    Osten, Rachel A.; Wolk, Scott J.

    2015-08-10

    We explore the ramification of associating the energetics of extreme magnetic reconnection events with transient mass-loss in a stellar analogy with solar eruptive events. We establish energy partitions relative to the total bolometric radiated flare energy for different observed components of stellar flares and show that there is rough agreement for these values with solar flares. We apply an equipartition between the bolometric radiated flare energy and kinetic energy in an accompanying mass ejection, seen in solar eruptive events and expected from reconnection. This allows an integrated flare rate in a particular waveband to be used to estimate the amount of associated transient mass-loss. This approach is supported by a good correspondence between observational flare signatures on high flaring rate stars and the Sun, which suggests a common physical origin. If the frequent and extreme flares that young solar-like stars and low-mass stars experience are accompanied by transient mass-loss in the form of coronal mass ejections, then the cumulative effect of this mass-loss could be large. We find that for young solar-like stars and active M dwarfs, the total mass lost due to transient magnetic eruptions could have significant impacts on disk evolution, and thus planet formation, and also exoplanet habitability.

  8. A study of the equatorial signatures of long period transient events (600 - 7200 s)

    NASA Astrophysics Data System (ADS)

    Santos, J.; Dutra, S.; Trivedi, N.; Vieira, L.; Echer, E.; Schuch, N.

    Transient variations in the H magnetic field component of magnetograms at high latitude are a common feature. They are associated with energy transference from solar wind to the magnetosphere. Abrupt changes in the solar wind generate Alfvén and fast mode waves through the magnetosphere. The Alfvén wave doesn't propagate in the direction perpendicular to the geomagnetic field, so equatorial signatures are probably caused by fast mode waves. On the other hand, complicated signatures observed at high latitudes represent a composition of Alfvén and fast mode waves. A second suggested propagation mechanism to low latitudes is the Earth-ionosphere wave-guide. In this work, geomagnetic data from the Brazilian magnetic stations at Belém (BLM), Eusébio (EUS), Ji-Paraná (JIP), São luis (SLZ) and São Martinho da Serra (SMS), all located near the geomagnetic equator, are used to look for equatorial signatures of transient events with periods of 600 - 7200s. This period range includes two special types of transient variations named Traveling convection vortices (TCV) and DP2 fluctuations. We try to identify their morphological characteristics and compare with the high latitude phenomena's characteristics. Satellite data (WIND, ACE and GOES) are used to see magnetosphere signatures and solar wind and interplanetary magnetic field (IMF) conditions during the events. The main objective is try to find the contribution of each propagation mechanism of these transient events arriving at the equatorial latitudes.

  9. The superluminous transient ASASSN-15lh as a tidal disruption event from a Kerr black hole

    NASA Astrophysics Data System (ADS)

    Leloudas, G.; Fraser, M.; Stone, N. C.; van Velzen, S.; Jonker, P. G.; Arcavi, I.; Fremling, C.; Maund, J. R.; Smartt, S. J.; Krìhler, T.; Miller-Jones, J. C. A.; Vreeswijk, P. M.; Gal-Yam, A.; Mazzali, P. A.; De Cia, A.; Howell, D. A.; Inserra, C.; Patat, F.; de Ugarte Postigo, A.; Yaron, O.; Ashall, C.; Bar, I.; Campbell, H.; Chen, T.-W.; Childress, M.; Elias-Rosa, N.; Harmanen, J.; Hosseinzadeh, G.; Johansson, J.; Kangas, T.; Kankare, E.; Kim, S.; Kuncarayakti, H.; Lyman, J.; Magee, M. R.; Maguire, K.; Malesani, D.; Mattila, S.; McCully, C. V.; Nicholl, M.; Prentice, S.; Romero-Cañizales, C.; Schulze, S.; Smith, K. W.; Sollerman, J.; Sullivan, M.; Tucker, B. E.; Valenti, S.; Wheeler, J. C.; Young, D. R.

    2016-12-01

    When a star passes within the tidal radius of a supermassive black hole, it will be torn apart1. For a star with the mass of the Sun (M ⊙) and a non-spinning black hole with a mass <108 M ⊙, the tidal radius lies outside the black hole event horizon2 and the disruption results in a luminous flare3-6. Here we report observations over a period of ten months of a transient, hitherto interpreted7 as a superluminous supernova8. Our data show that the transient rebrightened substantially in the ultraviolet and that the spectrum went through three different spectroscopic phases without ever becoming nebular. Our observations are more consistent with a tidal disruption event than a superluminous supernova because of the temperature evolution6, the presence of highly ionized CNO gas in the line of sight9 and our improved localization of the transient in the nucleus of a passive galaxy, where the presence of massive stars is highly unlikely10,11. While the supermassive black hole has a mass >108 M ⊙ 12,13, a star with the same mass as the Sun could be disrupted outside the event horizon if the black hole were spinning rapidly14. The rapid spin and high black hole mass can explain the high luminosity of this event.

  10. Single event induced transients in I/O devices - A characterization

    NASA Technical Reports Server (NTRS)

    Newberry, D. M.; Kaye, D. H.; Soli, G. A.

    1990-01-01

    The results of single-event upset (SEU) testing performed to evaluate the parametric transients, i.e., amplitude and duration, in several I/O devices, and the impact of these transients are discussed. The failure rate of these devices is dependent on the susceptibility of interconnected devices to the resulting transient change in the output of the I/O device. This failure rate, which is a function of the susceptibility of the interconnected device as well as the SEU response of the I/O device itself, may be significantly different from an upset rate calculated without taking these factors into account. The impact at the system level is discussed by way of an example.

  11. Transient events in the outer magnetosphere - Boundary waves of flux transfer events?

    NASA Technical Reports Server (NTRS)

    Sibeck, D. G.

    1992-01-01

    Simultaneous solar wind and magnetospheric observations are presented for a series of flux transfer events (FTEs) observed by the UKS and IRM spacecraft in the outer prenoon magnetosphere on October 28, 1984. The CCE satellite, located near local noon, observed an enhancement in the magnetospheric magnetic field strength 4 min prior to each IRM/UKS event, suggesting the antisunward propagation of a compression in the magnetopause surface. It is suggested that these compressions resulted from wavy magnetopause motion driven by variations in the solar wind dynamic pressure applied to the magnetosphere, rather than the motion of FTEs formed by magnetic merging. This hypothesis is confirmed by the fact that the events previously identified as FTEs occurred during a sequence of quasi-periodic (5-6 min) oscillations in the magnetospheric plasma velocity and magnetic field.

  12. Paleocene-Eocene Thermal Maximum not a transient event for North Atlantic

    NASA Astrophysics Data System (ADS)

    Lyman, J.; Norris, R.

    2009-04-01

    Rapid global warming 55 million years ago at the Paleocene-Eocene Thermal Maximum (PETM) has long been seen as a transient event. This event is accompanied by a rapid drop in carbon isotopes in most cores (carbon isotope excursion - CIE), followed by a slower recovery, with the entire CIE typically lasting between 150 to 200kyrs. This event is not transient in all cores, however. In Deep Sea Drilling Program (DSDP) Site 401, this event causes long-lasting changes in the isotopic content of the surface and thermocline dwelling foraminifera, far after the benthic foraminifera have recovered isotopically. Benthic foraminifera do show a recovery, but have a smaller overall excursion than the surface dwelling forms. This is most likely due to an expulsion of photosymbionts from the foraminifera, resulting in a bleaching event not unlike those seen in corals today. Unlike Ocean Drilling Program (ODP) Site 690, the color of the core and the mineral content also show no recovery. The lack of recovery in surface dwelling foraminiferal isotopes, color change, and mineral content indicate the North Atlantic was affected by this event long after other areas of the globe.

  13. Orbital decomposition for ill-behaved event sequences: transients and superordinate structures.

    PubMed

    Guastello, Stephen J; Peressini, Anthony F; Bond, Robert W

    2011-10-01

    Time series analysis is often challenged by the presence of transient functions. We examined some types of transients found in time series of events that lend themselves to symbolic dynamics analysis through the method of orbital decomposition, which is based on the principle that chaotic series arise from coupled oscillators. Synthetic data sets were constructed to study the impact of intrusive events, intrusive series, merged functions, non-coupled oscillators, and driving oscillations on the patterns of final statistics obtained from orbital decomposition analysis. Two real-world data sets - a logbook of the ritual behaviors of a patient with obsessive compulsive disorder and a time series of kill dates from an infamous serial murderer - were examined for non-ergodic properties similar to those found in the synthetic data.

  14. Method and apparatus for acquisition and tracking of light sources in a transient event rich environment

    NASA Technical Reports Server (NTRS)

    Kissh, Frank (Inventor); Flynn, David (Inventor); Fowski, Walter (Inventor); Abreu, Rene (Inventor); Miklus, Kenneth (Inventor); Bolin, Kenneth (Inventor)

    1993-01-01

    A method and apparatus for tracking a light source in a transient event rich environment locks on to a light source incident on a field-of-view 1 of a charge-coupled-device (CCD) array 6, validates the permanence of said light source and transmits data relating to the brilliance and location of said light source if said light source is determined to be permanent.

  15. Nonlinear denoising of transient signals with application to event-related potentials

    NASA Astrophysics Data System (ADS)

    Effern, A.; Lehnertz, K.; Schreiber, T.; Grunwald, T.; David, P.; Elger, C. E.

    2000-06-01

    We present a new wavelet-based method for the denoising of event-related potentials (ERPs), employing techniques recently developed for the paradigm of deterministic chaotic systems. The denoising scheme has been constructed to be appropriate for short and transient time sequences using circular state space embedding. Its effectiveness was successfully tested on simulated signals as well as on ERPs recorded from within a human brain. The method enables the study of individual ERPs against strong ongoing brain electrical activity.

  16. Design and implementation of a distributed Complex Event Processing system

    NASA Astrophysics Data System (ADS)

    Li, Yan; Shang, Yanlei

    2017-01-01

    Making use of the massive events from event sources such as sensors and bank transactions and extract valuable information is of significant importance. Complex Event Processing (CEP), a method of detecting complex events from simple events stream, provides a solution of processing data in real time fast and efficiently. However, a single node CEP system can't satisfy requirements of processing massive event streams from multitudinous event sources. Therefore, this article designs a distributed CEP system, which combine Siddhi, a CEP engine, and Storm, a distributed real time computation architecture. This system can construct topology automatically based on the event streams and execution plans provided by users and process the event streams parallel. Compared with single node complex event system, the distributed system can achieve better performance.

  17. Swift Follow-Up Observations of Candidate Gravitational-Wave Transient Events

    NASA Technical Reports Server (NTRS)

    Evans, P. A.; Fridriksson, J. K.; Gehrels, N.; Homan, J.; Osborne, J. P.; Siegel, M.; Beardmore, A.; Handbauer, P.; Gelbord, J.; Kennea, J. A.; hide

    2012-01-01

    We present the first multi-wavelength follow-up observations of two candidate gravitational-wave (GW) transient events recorded by LIGO and Virgo in their 2009-2010 science run. The events were selected with low latency by the network of GW detectors (within less than 10 minutes) and their candidate sky locations were observed by the Swift observatory (within 12 hr). Image transient detection was used to analyze the collected electromagnetic data, which were found to be consistent with background. Off-line analysis of the GW data alone has also established that the selected GW events show no evidence of an astrophysical origin; one of them is consistent with background and the other one was a test, part of a "blind injection challenge." With this work we demonstrate the feasibility of rapid follow-ups of GW transients and establish the sensitivity improvement joint electromagnetic and GW observations could bring. This is a first step toward an electromagnetic follow-up program in the regime of routine detections with the advanced GW instruments expected within this decade. In that regime, multi-wavelength observations will play a significant role in completing the astrophysical identification of GW sources. We present the methods and results from this first combined analysis and discuss its implications in terms of sensitivity for the present and future instruments.

  18. Swift Follow-up Observations of Candidate Gravitational-wave Transient Events

    NASA Astrophysics Data System (ADS)

    Evans, P. A.; Fridriksson, J. K.; Gehrels, N.; Homan, J.; Osborne, J. P.; Siegel, M.; Beardmore, A.; Handbauer, P.; Gelbord, J.; Kennea, J. A.; Smith, M.; Zhu, Q.; LIGO Scientific Collaboration; Virgo Collaboration; Aasi, J.; Abadie, J.; Abbott, B. P.; Abbott, R.; Abbott, T. D.; Abernathy, M.; Accadia, T.; Acernese, F.; Adams, C.; Adams, T.; Addesso, P.; Adhikari, R.; Affeldt, C.; Agathos, M.; Agatsuma, K.; Ajith, P.; Allen, B.; Allocca, A.; Amador Ceron, E.; Amariutei, D.; Anderson, S. B.; Anderson, W. G.; Arai, K.; Araya, M. C.; Ast, S.; Aston, S. M.; Astone, P.; Atkinson, D.; Aufmuth, P.; Aulbert, C.; Aylott, B. E.; Babak, S.; Baker, P.; Ballardin, G.; Ballmer, S.; Bao, Y.; Barayoga, J. C. B.; Barker, D.; Barone, F.; Barr, B.; Barsotti, L.; Barsuglia, M.; Barton, M. A.; Bartos, I.; Bassiri, R.; Bastarrika, M.; Basti, A.; Batch, J.; Bauchrowitz, J.; Bauer, Th. S.; Bebronne, M.; Beck, D.; Behnke, B.; Bejger, M.; Beker, M. G.; Bell, A. S.; Bell, C.; Belopolski, I.; Benacquista, M.; Berliner, J. M.; Bertolini, A.; Betzwieser, J.; Beveridge, N.; Beyersdorf, P. T.; Bhadbade, T.; Bilenko, I. A.; Billingsley, G.; Birch, J.; Biswas, R.; Bitossi, M.; Bizouard, M. A.; Black, E.; Blackburn, J. K.; Blackburn, L.; Blair, D.; Bland, B.; Blom, M.; Bock, O.; Bodiya, T. P.; Bogan, C.; Bond, C.; Bondarescu, R.; Bondu, F.; Bonelli, L.; Bonnand, R.; Bork, R.; Born, M.; Boschi, V.; Bose, S.; Bosi, L.; Bouhou, B.; Braccini, S.; Bradaschia, C.; Brady, P. R.; Braginsky, V. B.; Branchesi, M.; Brau, J. E.; Breyer, J.; Briant, T.; Bridges, D. O.; Brillet, A.; Brinkmann, M.; Brisson, V.; Britzger, M.; Brooks, A. F.; Brown, D. A.; Bulik, T.; Bulten, H. J.; Buonanno, A.; Burguet-Castell, J.; Buskulic, D.; Buy, C.; Byer, R. L.; Cadonati, L.; Cagnoli, G.; Calloni, E.; Camp, J. B.; Campsie, P.; Cannon, K.; Canuel, B.; Cao, J.; Capano, C. D.; Carbognani, F.; Carbone, L.; Caride, S.; Caudill, S.; Cavaglià, M.; Cavalier, F.; Cavalieri, R.; Cella, G.; Cepeda, C.; Cesarini, E.; Chalermsongsak, T.; Charlton, P.; Chassande-Mottin, E.; Chen, W.; Chen, X.; Chen, Y.; Chincarini, A.; Chiummo, A.; Cho, H. S.; Chow, J.; Christensen, N.; Chua, S. S. Y.; Chung, C. T. Y.; Chung, S.; Ciani, G.; Clara, F.; Clark, D. E.; Clark, J. A.; Clayton, J. H.; Cleva, F.; Coccia, E.; Cohadon, P.-F.; Colacino, C. N.; Colla, A.; Colombini, M.; Conte, A.; Conte, R.; Cook, D.; Corbitt, T. R.; Cordier, M.; Cornish, N.; Corsi, A.; Costa, C. A.; Coughlin, M.; Coulon, J.-P.; Couvares, P.; Coward, D. M.; Cowart, M.; Coyne, D. C.; Creighton, J. D. E.; Creighton, T. D.; Cruise, A. M.; Cumming, A.; Cunningham, L.; Cuoco, E.; Cutler, R. M.; Dahl, K.; Damjanic, M.; Danilishin, S. L.; D'Antonio, S.; Danzmann, K.; Dattilo, V.; Daudert, B.; Daveloza, H.; Davier, M.; Daw, E. J.; Day, R.; Dayanga, T.; De Rosa, R.; DeBra, D.; Debreczeni, G.; Degallaix, J.; Del Pozzo, W.; Dent, T.; Dergachev, V.; DeRosa, R.; Dhurandhar, S.; Di Fiore, L.; Di Lieto, A.; Di Palma, I.; Emilio, M. Di Paolo; Di Virgilio, A.; Díaz, M.; Dietz, A.; Donovan, F.; Dooley, K. L.; Doravari, S.; Dorsher, S.; Drago, M.; Drever, R. W. P.; Driggers, J. C.; Du, Z.; Dumas, J.-C.; Dwyer, S.; Eberle, T.; Edgar, M.; Edwards, M.; Effler, A.; Ehrens, P.; Eikenberry, S.; Endrőczi, G.; Engel, R.; Etzel, T.; Evans, K.; Evans, M.; Evans, T.; Factourovich, M.; Fafone, V.; Fairhurst, S.; Farr, B. F.; Favata, M.; Fazi, D.; Fehrmann, H.; Feldbaum, D.; Ferrante, I.; Ferrini, F.; Fidecaro, F.; Finn, L. S.; Fiori, I.; Fisher, R. P.; Flaminio, R.; Foley, S.; Forsi, E.; Forte, L. A.; Fotopoulos, N.; Fournier, J.-D.; Franc, J.; Franco, S.; Frasca, S.; Frasconi, F.; Frede, M.; Frei, M. A.; Frei, Z.; Freise, A.; Frey, R.; Fricke, T. T.; Friedrich, D.; Fritschel, P.; Frolov, V. V.; Fujimoto, M.-K.; Fulda, P. J.; Fyffe, M.; Gair, J.; Galimberti, M.; Gammaitoni, L.; Garcia, J.; Garufi, F.; Gáspár, M. E.; Gelencser, G.; Gemme, G.; Genin, E.; Gennai, A.; Gergely, L. Á.; Ghosh, S.; Giaime, J. A.; Giampanis, S.; Giardina, K. D.; Giazotto, A.; Gil-Casanova, S.; Gill, C.; Gleason, J.; Goetz, E.; González, G.; Gorodetsky, M. L.; Goßler, S.; Gouaty, R.; Graef, C.; Graff, P. B.; Granata, M.; Grant, A.; Gray, C.; Greenhalgh, R. J. S.; Gretarsson, A. M.; Griffo, C.; Grote, H.; Grover, K.; Grunewald, S.; Guidi, G. M.; Guido, C.; Gupta, R.; Gustafson, E. K.; Gustafson, R.; Hallam, J. M.; Hammer, D.; Hammond, G.; Hanks, J.; Hanna, C.; Hanson, J.; Harms, J.; Harry, G. M.; Harry, I. W.; Harstad, E. D.; Hartman, M. T.; Haughian, K.; Hayama, K.; Hayau, J.-F.; Heefner, J.; Heidmann, A.; Heintze, M. C.; Heitmann, H.; Hello, P.; Hemming, G.; Hendry, M. A.; Heng, I. S.; Heptonstall, A. W.; Herrera, V.; Heurs, M.; Hewitson, M.; Hild, S.; Hoak, D.; Hodge, K. A.; Holt, K.; Holtrop, M.; Hong, T.; Hooper, S.; Hough, J.; Howell, E. J.; Hughey, B.; Husa, S.; Huttner, S. H.; Huynh-Dinh, T.; Ingram, D. R.; Inta, R.; Isogai, T.; Ivanov, A.; Izumi, K.; Jacobson, M.; James, E.; Jang, Y. J.; Jaranowski, P.; Jesse, E.; Johnson, W. W.; Jones, D. I.; Jones, R.; Jonker, R. J. G.; Ju, L.; Kalmus, P.; Kalogera, V.; Kandhasamy, S.; Kang, G.; Kanner, J. B.; Kasprzack, M.; Kasturi, R.; Katsavounidis, E.; Katzman, W.; Kaufer, H.; Kaufman, K.; Kawabe, K.; Kawamura, S.; Kawazoe, F.; Keitel, D.; Kelley, D.; Kells, W.; Keppel, D. G.; Keresztes, Z.; Khalaidovski, A.; Khalili, F. Y.; Khazanov, E. A.; Kim, B. K.; Kim, C.; Kim, H.; Kim, K.; Kim, N.; Kim, Y. M.; King, P. J.; Kinzel, D. L.; Kissel, J. S.; Klimenko, S.; Kline, J.; Kokeyama, K.; Kondrashov, V.; Koranda, S.; Korth, W. Z.; Kowalska, I.; Kozak, D.; Kringel, V.; Krishnan, B.; Królak, A.; Kuehn, G.; Kumar, P.; Kumar, R.; Kurdyumov, R.; Kwee, P.; Lam, P. K.; Landry, M.; Langley, A.; Lantz, B.; Lastzka, N.; Lawrie, C.; Lazzarini, A.; Le Roux, A.; Leaci, P.; Lee, C. H.; Lee, H. K.; Lee, H. M.; Leong, J. R.; Leonor, I.; Leroy, N.; Letendre, N.; Lhuillier, V.; Li, J.; Li, T. G. F.; Lindquist, P. E.; Litvine, V.; Liu, Y.; Liu, Z.; Lockerbie, N. A.; Lodhia, D.; Logue, J.; Lorenzini, M.; Loriette, V.; Lormand, M.; Losurdo, G.; Lough, J.; Lubinski, M.; Lück, H.; Lundgren, A. P.; Macarthur, J.; Macdonald, E.; Machenschalk, B.; MacInnis, M.; Macleod, D. M.; Mageswaran, M.; Mailand, K.; Majorana, E.; Maksimovic, I.; Malvezzi, V.; Man, N.; Mandel, I.; Mandic, V.; Mantovani, M.; Marchesoni, F.; Marion, F.; Márka, S.; Márka, Z.; Markosyan, A.; Maros, E.; Marque, J.; Martelli, F.; Martin, I. W.; Martin, R. M.; Marx, J. N.; Mason, K.; Masserot, A.; Matichard, F.; Matone, L.; Matzner, R. A.; Mavalvala, N.; Mazzolo, G.; McCarthy, R.; McClelland, D. E.; McDaniel, P.; McGuire, S. C.; McIntyre, G.; McIver, J.; Meadors, G. D.; Mehmet, M.; Meier, T.; Melatos, A.; Melissinos, A. C.; Mendell, G.; Menéndez, D. F.; Mercer, R. A.; Meshkov, S.; Messenger, C.; Meyer, M. S.; Miao, H.; Michel, C.; Milano, L.; Miller, J.; Minenkov, Y.; Mingarelli, C. M. F.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Moe, B.; Mohan, M.; Mohapatra, S. R. P.; Moraru, D.; Moreno, G.; Morgado, N.; Morgia, A.; Mori, T.; Morriss, S. R.; Mosca, S.; Mossavi, K.; Mours, B.; Mow-Lowry, C. M.; Mueller, C. L.; Mueller, G.; Mukherjee, S.; Mullavey, A.; Müller-Ebhardt, H.; Munch, J.; Murphy, D.; Murray, P. G.; Mytidis, A.; Nash, T.; Naticchioni, L.; Necula, V.; Nelson, J.; Neri, I.; Newton, G.; Nguyen, T.; Nishizawa, A.; Nitz, A.; Nocera, F.; Nolting, D.; Normandin, M. E.; Nuttall, L.; Ochsner, E.; O'Dell, J.; Oelker, E.; Ogin, G. H.; Oh, J. J.; Oh, S. H.; Oldenberg, R. G.; O'Reilly, B.; O'Shaughnessy, R.; Osthelder, C.; Ott, C. D.; Ottaway, D. J.; Ottens, R. S.; Overmier, H.; Owen, B. J.; Page, A.; Palladino, L.; Palomba, C.; Pan, Y.; Pankow, C.; Paoletti, F.; Paoletti, R.; Papa, M. A.; Parisi, M.; Pasqualetti, A.; Passaquieti, R.; Passuello, D.; Pedraza, M.; Penn, S.; Perreca, A.; Persichetti, G.; Phelps, M.; Pichot, M.; Pickenpack, M.; Piergiovanni, F.; Pierro, V.; Pihlaja, M.; Pinard, L.; Pinto, I. M.; Pitkin, M.; Pletsch, H. J.; Plissi, M. V.; Poggiani, R.; Pöld, J.; Postiglione, F.; Poux, C.; Prato, M.; Predoi, V.; Prestegard, T.; Price, L. R.; Prijatelj, M.; Principe, M.; Privitera, S.; Prix, R.; Prodi, G. A.; Prokhorov, L. G.; Puncken, O.; Punturo, M.; Puppo, P.; Quetschke, V.; Quitzow-James, R.; Raab, F. J.; Rabeling, D. S.; Rácz, I.; Radkins, H.; Raffai, P.; Rakhmanov, M.; Ramet, C.; Rankins, B.; Rapagnani, P.; Raymond, V.; Re, V.; Reed, C. M.; Reed, T.; Regimbau, T.; Reid, S.; Reitze, D. H.; Ricci, F.; Riesen, R.; Riles, K.; Roberts, M.; Robertson, N. A.; Robinet, F.; Robinson, C.; Robinson, E. L.; Rocchi, A.; Roddy, S.; Rodriguez, C.; Rodruck, M.; Rolland, L.; Rollins, J. G.; Romano, J. D.; Romano, R.; Romie, J. H.; Rosińska, D.; Röver, C.; Rowan, S.; Rüdiger, A.; Ruggi, P.; Ryan, K.; Salemi, F.; Sammut, L.; Sandberg, V.; Sankar, S.; Sannibale, V.; Santamaría, L.; Santiago-Prieto, I.; Santostasi, G.; Saracco, E.; Sassolas, B.; Sathyaprakash, B. S.; Saulson, P. R.; Savage, R. L.; Schilling, R.; Schnabel, R.; Schofield, R. M. S.; Schulz, B.; Schutz, B. F.; Schwinberg, P.; Scott, J.; Scott, S. M.; Seifert, F.; Sellers, D.; Sentenac, D.; Sergeev, A.; Shaddock, D. A.; Shaltev, M.; Shapiro, B.; Shawhan, P.; Shoemaker, D. H.; Sidery, T. L.; Siemens, X.; Sigg, D.; Simakov, D.; Singer, A.; Singer, L.; Sintes, A. M.; Skelton, G. R.; Slagmolen, B. J. J.; Slutsky, J.; Smith, J. R.; Smith, M. R.; Smith, R. J. E.; Smith-Lefebvre, N. D.; Somiya, K.; Sorazu, B.; Speirits, F. C.; Sperandio, L.; Stefszky, M.; Steinert, E.; Steinlechner, J.; Steinlechner, S.; Steplewski, S.; Stochino, A.; Stone, R.; Strain, K. A.; Strigin, S. E.; Stroeer, A. S.; Sturani, R.; Stuver, A. L.; Summerscales, T. Z.; Sung, M.; Susmithan, S.; Sutton, P. J.; Swinkels, B.; Szeifert, G.; Tacca, M.; Taffarello, L.; Talukder, D.; Tanner, D. B.; Tarabrin, S. P.; Taylor, R.; ter Braack, A. P. M.; Thomas, P.; Thorne, K. A.; Thorne, K. S.; Thrane, E.; Thüring, A.; Titsler, C.; Tokmakov, K. V.; Tomlinson, C.; Toncelli, A.; Tonelli, M.; Torre, O.; Torres, C. V.; Torrie, C. I.; Tournefier, E.; Travasso, F.; Traylor, G.; Tse, M.; Ugolini, D.; Vahlbruch, H.; Vajente, G.; van den Brand, J. F. J.; Van Den Broeck, C.; van der Putten, S.; van Veggel, A. A.; Vass, S.; Vasuth, M.; Vaulin, R.; Vavoulidis, M.; Vecchio, A.; Vedovato, G.; Veitch, J.; Veitch, P. J.; Venkateswara, K.; Verkindt, D.; Vetrano, F.; Viceré, A.; Villar, A. E.; Vinet, J.-Y.; Vitale, S.; Vocca, H.; Vorvick, C.; Vyatchanin, S. P.; Wade, A.; Wade, L.; Wade, M.; Waldman, S. J.; Wallace, L.; Wan, Y.; Wang, M.; Wang, X.; Wanner, A.; Ward, R. L.; Was, M.; Weinert, M.; Weinstein, A. J.; Weiss, R.; Welborn, T.; Wen, L.; Wessels, P.; West, M.; Westphal, T.; Wette, K.; Whelan, J. T.; Whitcomb, S. E.; White, D. J.; Whiting, B. F.; Wiesner, K.; Wilkinson, C.; Willems, P. A.; Williams, L.; Williams, R.; Willke, B.; Wimmer, M.; Winkelmann, L.; Winkler, W.; Wipf, C. C.; Wiseman, A. G.; Wittel, H.; Woan, G.; Wooley, R.; Worden, J.; Yablon, J.; Yakushin, I.; Yamamoto, H.; Yamamoto, K.; Yancey, C. C.; Yang, H.; Yeaton-Massey, D.; Yoshida, S.; Yvert, M.; Zadrożny, A.; Zanolin, M.; Zendri, J.-P.; Zhang, F.; Zhang, L.; Zhao, C.; Zotov, N.; Zucker, M. E.; Zweizig, J.

    2012-12-01

    We present the first multi-wavelength follow-up observations of two candidate gravitational-wave (GW) transient events recorded by LIGO and Virgo in their 2009-2010 science run. The events were selected with low latency by the network of GW detectors (within less than 10 minutes) and their candidate sky locations were observed by the Swift observatory (within 12 hr). Image transient detection was used to analyze the collected electromagnetic data, which were found to be consistent with background. Off-line analysis of the GW data alone has also established that the selected GW events show no evidence of an astrophysical origin; one of them is consistent with background and the other one was a test, part of a "blind injection challenge." With this work we demonstrate the feasibility of rapid follow-ups of GW transients and establish the sensitivity improvement joint electromagnetic and GW observations could bring. This is a first step toward an electromagnetic follow-up program in the regime of routine detections with the advanced GW instruments expected within this decade. In that regime, multi-wavelength observations will play a significant role in completing the astrophysical identification of GW sources. We present the methods and results from this first combined analysis and discuss its implications in terms of sensitivity for the present and future instruments.

  19. [Prevention of vascular events after transient ischemic attack or cerebral infarct].

    PubMed

    Leys, Didier; Cordonnier, Charlotte

    2006-09-15

    After a first cerebral ischemic event, secondary prevention should be started as soon as possible, especially in transient ischemic attacks where the risk of recurrence is the highest, especially during the first week, needing a diagnostic workup in a short period of time, secondary prevention measures depending on the presumed cause of the event. Secondary prevention of vascular events after transient ischemic attack or cerebral infarct consists of 3 types of strategies: 1. treatment of risk factors for stroke, especially high blood pressure, high cholesterol and smoking cessation; 2. aspirin (50 to 325 mg), or clopidogrel, or association aspirine-dipyridamole in high-risk subjects, or warfarin in patients with high-risk cardiopathies; and 3. carotid surgery in patients selected by clinical and imaging criteria. Other strategies are currently partly under evaluation: statins in normocholesterolemic ischemic stroke patients without coronary event, angioplasty with stenting. Audits of practice are necessary to determine whether patients are actually treated according to scientific evidence. This is a crucial issue if we want the results of trials to be translated in the true life, and really improve health at the community level.

  20. A Patch-Based Method for Repetitive and Transient Event Detection in Fluorescence Imaging

    PubMed Central

    Boulanger, Jérôme; Gidon, Alexandre; Kervran, Charles; Salamero, Jean

    2010-01-01

    Automatic detection and characterization of molecular behavior in large data sets obtained by fast imaging in advanced light microscopy become key issues to decipher the dynamic architectures and their coordination in the living cell. Automatic quantification of the number of sudden and transient events observed in fluorescence microscopy is discussed in this paper. We propose a calibrated method based on the comparison of image patches expected to distinguish sudden appearing/vanishing fluorescent spots from other motion behaviors such as lateral movements. We analyze the performances of two statistical control procedures and compare the proposed approach to a frame difference approach using the same controls on a benchmark of synthetic image sequences. We have then selected a molecular model related to membrane trafficking and considered real image sequences obtained in cells stably expressing an endocytic-recycling trans-membrane protein, the Langerin-YFP, for validation. With this model, we targeted the efficient detection of fast and transient local fluorescence concentration arising in image sequences from a data base provided by two different microscopy modalities, wide field (WF) video microscopy using maximum intensity projection along the axial direction and total internal reflection fluorescence microscopy. Finally, the proposed detection method is briefly used to statistically explore the effect of several perturbations on the rate of transient events detected on the pilot biological model. PMID:20976222

  1. Observations of a transient event in the subsolar magnetosheath during strongly northward IMF

    NASA Astrophysics Data System (ADS)

    Dias Silveira, M. V.; Sibeck, D. G.; Gonzalez, W. D.; Koga, D.

    2013-12-01

    We present multipoint THEMIS observation of a transient event in the subsolar magnetosheath on July 10, 2007. The event exhibits some features of a flux transfer event, such as a bipolar variation in the magnetic field component normal to the nominal magnetopause centered on a peak in the total magnetic field strength. Four THEMIS spacecraft were in the magnetosheath and one in the magnetosphere. Timing analysis and the absence of flow perturbation suggest that the event is a small scale structure (~0.12 Re in the direction of the flow) moving with the background magnetosheath flow. Despite the inferred small size of the event, THC and THD both observed large amplitude (~40 nT) bipolar magnetic field signatures normal to the nominal magnetopause. Nearby spacecraft THE (only 0.2 Re further outward in the Xgsm direction) observed no significant magnetic field perturbation. Neither did THB or THA, located further away in the magnetosheath and magnetosphere, respectively. During the event, the IMF was strongly northward (approximately 20nT), which does not favor subsolar magnetic reconnection. Inside the structure, the magnetic field briefly rotates 90° away from northward to dawnward. Ions stream antiparallel to the magnetic field in the magnetosheath, parallel to the magnetic field in the event.

  2. SAS 3 observations of two X-ray transient events with precursors

    NASA Technical Reports Server (NTRS)

    Hoffman, J. A.; Lewin, W. H. G.; Doty, J.; Jernigan, J. G.; Haney, M.; Richardson, J. A.

    1978-01-01

    SAS 3 has observed two unusual fast transient X-ray events from different sources, one lasting about 150 s and one, approximately 1500 s. Both events were preceded by precursor pulses which lasted a few seconds and which rose and fell in less than 0.4 s. The precursors were separated from the 'main' events by several seconds, during which no X-rays were detected. There are similarities between the two main events and X-ray bursts in both their temporal and spectral evolution. The spectra of the main events started out much softer than the spectra of the precursors, became harder as they approached maximum intensity, and softened as they decayed. In the 1500-s event, X-rays with energies greater than 10 keV were delayed by about 80 s compared with 1.5-6-keV X-rays. A blackbody fit to the spectral data of the main event of approximately 1500-s duration gives a maximum temperature of 29 million K and a radius for the emitting region of at least about 9 km (at a distance of 10 kpc); this is similar to the temperature and sizes found for several X-ray burst sources.

  3. Transient Astronomical Events as Inspiration Sources of Medieval and Renaissance Art

    NASA Astrophysics Data System (ADS)

    Incerti, M.; Bònoli, F.; Polcaro, V. F.

    2011-06-01

    It is known long since that a number of exceptional and highly impressive astronomical events have been represented in Medieval artworks. We just remember the Bayeux Tapestry and Giotto's The Adoration of the Magi in the Scrovegni Chapel in Padua, representing the P/Halley comet transits of 1067 and 1301, respectively, while The Apparition of Star to Magi fresco in the San Pietro in Valle Abbey in Ferentillo (1182) has been suggested to represent the 1181 supernova. However, no systematic survey of figurative Medieval and Renaissance art has been performed to date, in order to analyzing the role of transient astronomical events as inspiration sources of artworks in these epochs. In this work, we analyze a significant number of artworks, dated between the 9th and 16th century and representing figurative elements in some way connected with astronomy, in order to evaluate if they have been influenced by coeval extraordinary astronomical events.

  4. Composition of transient events in the solar wind: Ulysses/SWICS observations

    NASA Technical Reports Server (NTRS)

    Galvin, A. B.; Cohen, C. M. S.; Gloeckler, G.; vonSteiger, R.; Geiss, J.

    1995-01-01

    The Ulysses mission covers an extensive data base which includes an in-ecliptic phase (Oct 1990 - Feb 1992), a southern hemisphere polar pass (with a southernmost point of 80 deg S heliographic latitude reached in Sept 1994). and a south to north transit passing through the ecliptic plane (March 1995). The Solar Wind Ion Composition Spectrometer measures solar wind ion composition, including charge state composition. for all types of solar wind flows. In-ecliptic measurements of the charge states of solar wind heavy ions in transient-related solar wind. such as solar wind associated with coronal mass c ejections (CMEs), typically indicate hotter than normal coronal temperatures. This distinction is not as prevalent for higher latitude observations. In this paper, we present temporal and latitudinal variations in the charge state composition of Oxygen, Silicon, and Iron for several transient-related solar wind events.

  5. Far from thunderstorm UV transient events in the atmosphere measured by Vernov satellite

    NASA Astrophysics Data System (ADS)

    Morozenko, Violetta; Klimov, Pavel; Khrenov, Boris; Gali, Garipov; Margarita, Kaznacheeva; Mikhail, Panasyuk; Sergei, Svertilov; Robert, Holzworth

    2016-04-01

    The steady self-contained classification of events such as sprites, elves, blue jets emerged for the period of transient luminous events (TLE) observation. In accordance with TLE origin theories the presence of the thunderstorm region where the lightnings with the large peak current generating in is necessary. However, some far-from-thunderstorm region events were also detected and revealed to us another TLE generating mechanisms. For the discovering of the TLE nature the Universitetsky-Tatiana-2 and Vernov satellites were equipped with ultraviolet (240-400 nm) and red-infrared ( >610 nm) detectors. In both detector it was carried out regardless the lightnings with the guidance by the flashes in the UV wavelength where lightning's emitting is quite faint. The lowered threshold on the Vernov satellite allowed to select the great amount of TLE with the numerous far-from-thunderstorm region events examples. such events were not conjuncted with lightning activity measured by global lightning location network (WWLLN) on the large area of approximately 107 km2 for 30 minutes before and after the time of registration. The characteristic features of this type of event are: the absence of significant signal in the red-infrared detector's channel; a relatively small number of photons (less than 5 ṡ 1021). A large number of without lightning flash were detected at high latitudes over the ocean (30°S - 60°S). Lightning activity in the magnetic conjugate point also was analyzed. The relationship of far-from-thunderstorm region events with the specific lightning discharges didn't confirmed. Far-from-thunderstorm events - a new type of transient phenomena in the upper atmosphere is not associated with the thunderstorm activity. The mechanism of such discharges is not clear, though it was accumulated a sufficient amount of experimental facts of the existence of such flashes. According to the data of Vernov satellite the temporal profile, duration, location with earth

  6. Timing of transients: quantifying reaching times and transient behavior in complex systems

    NASA Astrophysics Data System (ADS)

    Kittel, Tim; Heitzig, Jobst; Webster, Kevin; Kurths, Jürgen

    2017-08-01

    In dynamical systems, one may ask how long it takes for a trajectory to reach the attractor, i.e. how long it spends in the transient phase. Although for a single trajectory the mathematically precise answer may be infinity, it still makes sense to compare different trajectories and quantify which of them approaches the attractor earlier. In this article, we categorize several problems of quantifying such transient times. To treat them, we propose two metrics, area under distance curve and regularized reaching time, that capture two complementary aspects of transient dynamics. The first, area under distance curve, is the distance of the trajectory to the attractor integrated over time. It measures which trajectories are ‘reluctant’, i.e. stay distant from the attractor for long, or ‘eager’ to approach it right away. Regularized reaching time, on the other hand, quantifies the additional time (positive or negative) that a trajectory starting at a chosen initial condition needs to approach the attractor as compared to some reference trajectory. A positive or negative value means that it approaches the attractor by this much ‘earlier’ or ‘later’ than the reference, respectively. We demonstrated their substantial potential for application with multiple paradigmatic examples uncovering new features.

  7. Simulation of air admission in a propeller hydroturbine during transient events

    NASA Astrophysics Data System (ADS)

    Nicolle, J.; Morissette, J.-F.

    2016-11-01

    In this study, multiphysic simulations are carried out in order to model fluid loading and structural stresses on propeller blades during startup and runaway. It is found that air admission plays an important role during these transient events and that biphasic simulations are therefore required. At the speed no load regime, a large air pocket with vertical free surface forms in the centre of the runner displacing the water flow near the shroud. This significantly affects the torque developed on the blades and thus structural loading. The resulting pressures are applied to a quasi-static structural model and good agreement is obtained with experimental strain gauge data.

  8. Computer aided detection of transient inflation events at Alaskan volcanoes using GPS measurements from 2005-2015

    NASA Astrophysics Data System (ADS)

    Li, Justin D.; Rude, Cody M.; Blair, David M.; Gowanlock, Michael G.; Herring, Thomas A.; Pankratius, Victor

    2016-11-01

    Analysis of transient deformation events in time series data observed via networks of continuous Global Positioning System (GPS) ground stations provide insight into the magmatic and tectonic processes that drive volcanic activity. Typical analyses of spatial positions originating from each station require careful tuning of algorithmic parameters and selection of time and spatial regions of interest to observe possible transient events. This iterative, manual process is tedious when attempting to make new discoveries and does not easily scale with the number of stations. Addressing this challenge, we introduce a novel approach based on a computer-aided discovery system that facilitates the discovery of such potential transient events. The advantages of this approach are demonstrated by actual detections of transient deformation events at volcanoes selected from the Alaska Volcano Observatory database using data recorded by GPS stations from the Plate Boundary Observatory network. Our technique successfully reproduces the analysis of a transient signal detected in the first half of 2008 at Akutan volcano and is also directly applicable to 3 additional volcanoes in Alaska, with the new detection of 2 previously unnoticed inflation events: in early 2011 at Westdahl and in early 2013 at Shishaldin. This study also discusses the benefits of our computer-aided discovery approach for volcanology in general. Advantages include the rapid analysis on multi-scale resolutions of transient deformation events at a large number of sites of interest and the capability to enhance reusability and reproducibility in volcano studies.

  9. Modeling of transient dust events in fusion edge plasmas with DUSTT-UEDGE code

    NASA Astrophysics Data System (ADS)

    Smirnov, R. D.; Krasheninnikov, S. I.; Pigarov, A. Yu.; Rognlien, T. D.

    2016-10-01

    It is well known that dust can be produced in fusion devices due to various processes involving structural damage of plasma exposed materials. Recent computational and experimental studies have demonstrated that dust production and associated with it plasma contamination can present serious challenges in achieving sustained fusion reaction in future fusion devices, such as ITER. To analyze the impact, which dust can have on performance of fusion plasmas, modeling of coupled dust and plasma transport with DUSTT-UEDGE code is used by the authors. In past, only steady-state computational studies, presuming continuous source of dust influx, were performed due to iterative nature of DUSTT-UEDGE code coupling. However, experimental observations demonstrate that intermittent injection of large quantities of dust, often associated with transient plasma events, may severely impact fusion plasma conditions and even lead to discharge termination. In this work we report on progress in coupling of DUSTT-UEDGE codes in time-dependent regime, which allows modeling of transient dust-plasma transport processes. The methodology and details of the time-dependent code coupling, as well as examples of simulations of transient dust-plasma transport phenomena will be presented. These include time-dependent modeling of impact of short out-bursts of different quantities of tungsten dust in ITER divertor on the edge plasma parameters. The plasma response to the out-bursts with various duration, location, and ejected dust sizes will be analyzed.

  10. The role of endothelial progenitor cells in transient ischemic attack patients for future cerebrovascular events

    PubMed Central

    Meamar, Rokhsareh; Nikyar, Hamidreza; Dehghani, Leila; Talebi, Maedeh; Dehghani, Marzieh; Ghasemi, Marzieh; Ansari, Behnaz; Saadatnia, Mohammad

    2016-01-01

    Background: The role of endothelial progenitor cells (EPCs) in the maintenance of vascularization following ischemic brain after experimental stroke has been established. Accordingly, in this study, we evaluated the role of circulating EPCs in transient ischemic attack (TIA) patients for future cerebrovascular (CV) events. Materials and Methods: The level of circulating EPCs (staining markers: CD34, CD309) were determined using flow cytometry at 24 h after TIA in thirty consecutive patients. The EPCs level was also evaluated once in thirty healthy volunteers. Over a period of 12 months, all patients were evaluated by an experienced neurologist for recurrent TIA, stroke or death induced by CV disorders. Results: Circulating EPCs increased in patients group following the first attack of TIA when compared with controls. By analysis of covariance, cardiovascular event history, hyperlipidemia, and statin therapy remained significant independent predictors of EPCs. The mean (standard deviation) duration of follow-up was 10.5 (3.1) months (range, 2–12 months). During follow-up, a total of three patients died due to CV accident and four patients experienced again recurrent TIA. By analyzing data with Cox regression, EPC did not predict the future CV events in TIA patients. Conclusion: Increased incidence of future CV events did not occur in those patients with elevated EPCs in the first attack of TIA. The significant predicting factors of EPCs were cardiovascular event history, hyperlipidemia, and statin therapy. PMID:27904593

  11. Single Event Transient and TID Study in 28 nm UTBB FDSOI Technology

    NASA Astrophysics Data System (ADS)

    Liu, Rui; Evans, Adrian; Chen, Li; Li, Yuanqing; Glorieux, Maximilien; Wong, Richard; Wen, Shi-Jie; Cunha, Joao; Summerer, Leopold; Ferlet-Cavrois, Véronique

    2017-01-01

    Measuring single-event transient (SET) pulse widths is critical for developing proper mitigation schemes to single-event effects (SEE), especially for advanced technologies. This paper presents a test chip design implementing advanced techniques for measuring SETs implemented in a 28 nm Ultra-Thin Body and Box (UTBB) FDSOI technology. Experimental results of heavy ion and Co-60 irradiation experiments are presented. The heavy ion experiments confirm that this technology has very low SEE sensitivity. Laser test results show that pulse distortion (broadening) plays a key role when evaluating the effect of SETs. Total Ionizing Dose (TID) effects were also evaluated by measuring the Ring Oscillator (RO) frequencies and static current during heavy ion and Co-60 irradiation. Experimental results showed that the RO frequencies degraded up to 10% (heavy ion), and 40% (Co-60) after 1000 krad(Si) irradiation, but the logic in the chip functioned without error.

  12. Total Dose Effects on Single Event Transients in Digital CMOS and Linear Bipolar Circuits

    NASA Technical Reports Server (NTRS)

    Buchner, S.; McMorrow, D.; Sibley, M.; Eaton, P.; Mavis, D.; Dusseau, L.; Roche, N. J-H.; Bernard, M.

    2009-01-01

    This presentation discusses the effects of ionizing radiation on single event transients (SETs) in circuits. The exposure of integrated circuits to ionizing radiation changes electrical parameters. The total ionizing dose effect is observed in both complementary metal-oxide-semiconductor (CMOS) and bipolar circuits. In bipolar circuits, transistors exhibit grain degradation, while in CMOS circuits, transistors exhibit threshold voltage shifts. Changes in electrical parameters can cause changes in single event upset(SEU)/SET rates. Depending on the effect, the rates may increase or decrease. Therefore, measures taken for SEU/SET mitigation might work at the beginning of a mission but not at the end following TID exposure. The effect of TID on SET rates should be considered if SETs cannot be tolerated.

  13. Estimation of the radial force on the tokamak vessel wall during fast transient events

    SciTech Connect

    Pustovitov, V. D.

    2016-11-15

    The radial force balance in a tokamak during fast transient events with a duration much shorter than the resistive time of the vacuum vessel wall is analyzed. The aim of the work is to analytically estimate the resulting integral radial force on the wall. In contrast to the preceding study [Plasma Phys. Rep. 41, 952 (2015)], where a similar problem was considered for thermal quench, simultaneous changes in the profiles and values of the pressure and plasma current are allowed here. Thereby, the current quench and various methods of disruption mitigation used in the existing tokamaks and considered for future applications are also covered. General formulas for the force at an arbitrary sequence or combination of events are derived, and estimates for the standard tokamak model are made. The earlier results and conclusions are confirmed, and it is shown that, in the disruption mitigation scenarios accepted for ITER, the radial forces can be as high as in uncontrolled disruptions.

  14. Mechanism of single-event transient pulse quenching between dummy gate isolated logic nodes

    NASA Astrophysics Data System (ADS)

    Chen, Jian-Jun; Chi, Ya-Qing; Liang, Bin

    2015-01-01

    As integrated circuits scale down in size, a single high-energy ion strike often affects multiple adjacent logic nodes. The so-called single-event transient (SET) pulse quenching induced by single-event charge sharing collection has been widely studied. In this paper, SET pulse quenching enhancement is found in dummy gate isolated adjacent logic nodes compared with that isolated by the common shallow trench isolation (STI). The physical mechanism is studied in depth and this isolation technique is explored for SET mitigation in combinational standard cells. Three-dimensional (3D) technology computer-aided design simulation (TCAD) results show that this technique can achieve efficient SET mitigation. Project supported by the National Natural Science Foundation of China (Grant No. 61376109) and the Opening Project of National Key Laboratory of Science and Technology on Reliability Physics and Application Technology of Electrical Component, China (Grant No. ZHD201202).

  15. Efficient visual search from synchronized auditory signals requires transient audiovisual events.

    PubMed

    Van der Burg, Erik; Cass, John; Olivers, Christian N L; Theeuwes, Jan; Alais, David

    2010-05-14

    A prevailing view is that audiovisual integration requires temporally coincident signals. However, a recent study failed to find any evidence for audiovisual integration in visual search even when using synchronized audiovisual events. An important question is what information is critical to observe audiovisual integration. Here we demonstrate that temporal coincidence (i.e., synchrony) of auditory and visual components can trigger audiovisual interaction in cluttered displays and consequently produce very fast and efficient target identification. In visual search experiments, subjects found a modulating visual target vastly more efficiently when it was paired with a synchronous auditory signal. By manipulating the kind of temporal modulation (sine wave vs. square wave vs. difference wave; harmonic sine-wave synthesis; gradient of onset/offset ramps) we show that abrupt visual events are required for this search efficiency to occur, and that sinusoidal audiovisual modulations do not support efficient search. Thus, audiovisual temporal alignment will only lead to benefits in visual search if the changes in the component signals are both synchronized and transient. We propose that transient signals are necessary in synchrony-driven binding to avoid spurious interactions with unrelated signals when these occur close together in time.

  16. Efficient Visual Search from Synchronized Auditory Signals Requires Transient Audiovisual Events

    PubMed Central

    Van der Burg, Erik; Cass, John; Olivers, Christian N. L.; Theeuwes, Jan; Alais, David

    2010-01-01

    Background A prevailing view is that audiovisual integration requires temporally coincident signals. However, a recent study failed to find any evidence for audiovisual integration in visual search even when using synchronized audiovisual events. An important question is what information is critical to observe audiovisual integration. Methodology/Principal Findings Here we demonstrate that temporal coincidence (i.e., synchrony) of auditory and visual components can trigger audiovisual interaction in cluttered displays and consequently produce very fast and efficient target identification. In visual search experiments, subjects found a modulating visual target vastly more efficiently when it was paired with a synchronous auditory signal. By manipulating the kind of temporal modulation (sine wave vs. square wave vs. difference wave; harmonic sine-wave synthesis; gradient of onset/offset ramps) we show that abrupt visual events are required for this search efficiency to occur, and that sinusoidal audiovisual modulations do not support efficient search. Conclusions/Significance Thus, audiovisual temporal alignment will only lead to benefits in visual search if the changes in the component signals are both synchronized and transient. We propose that transient signals are necessary in synchrony-driven binding to avoid spurious interactions with unrelated signals when these occur close together in time. PMID:20498844

  17. Migration of seismic scatterers associated with the 1993 Parkfield aseismic transient event.

    PubMed

    Niu, Fenglin; Silver, Paul G; Nadeau, Robert M; McEvilly, Thomas V

    2003-12-04

    The time-varying deformation field within a fault zone, particularly at depths where earthquakes occur, is important for understanding fault behaviour and its relation to earthquake occurrence. But detection of this temporal variation has been extremely difficult, although laboratory studies have long suggested that certain structural changes, such as the properties of crustal fractures, should be seismically detectable. Here we present evidence that such structural changes are indeed observable. In particular, we find a systematic temporal variation in the seismograms of repeat microearthquakes that occurred on the Parkfield segment of the San Andreas fault over the decade 1987-97. Our analysis reveals a change of the order of 10 m in the location of scatterers which plausibly lie within the fault zone at a depth of approximately 3 km. The motion of the scatterers is coincident, in space and time, with the onset of a well documented aseismic transient (deformation event). We speculate that this structural change is the result of a stress-induced redistribution of fluids in fluid-filled fractures caused by the transient event.

  18. Complexity and Extreme Events: Interdisciplinary Science of Natural Hazards

    NASA Astrophysics Data System (ADS)

    Sharma, A. Surjalal; Baker, Daniel N.; Bunde, Armin; Dimri, Vijay P.

    2010-07-01

    Chapman Conference on Complexity and Extreme Events in Geosciences; Hyderabad, India, 15-19 February 2010; Extreme events are key themes in geosciences research because of their devastating effects on society and their scientific complexities. The ever increasing economic and human losses from natural hazards underscore the urgency for improving understanding of extreme events to develop effective strategies to reduce their impact. Recent advances in nonlinear geophysics such as the role of long-term correlations and clustering, predictability of complex dynamical systems, and new approaches to nonequilibium phenomena have led to a new framework for understanding extreme events. The Chapman Conference on Complexity and Extreme Events in Geosciences was held to explore this emerging interdisciplinary science, consolidate the recent understanding, and define new research directions.

  19. Transient paralysis during acupuncture therapy: a case report of an adverse event.

    PubMed

    Beable, Anne

    2013-09-01

    A patient with apparently well-controlled epilepsy with a painful musculoskeletal condition was treated successfully with two sessions of acupuncture. However, 4 h after the first treatment and during the second, an adverse event involving impairment of consciousness occurred. The patient subsequently experienced an increased frequency of complex partial seizures resulting in the loss of his driving licence. A detailed retrospective review of the past medical history indicated that the patient probably had comorbidities in the form of rapid eye movement sleep behaviour disorder and dysfunctional somatosensory/vestibular processing. Acupuncture may have triggered the adverse event via shared neurosubstrates. This adverse event raises possible implications regarding safe clinical acupuncture practice.

  20. Spatiotemporal evolution of a transient slip event on the San Andreas fault near Parkfield, California

    USGS Publications Warehouse

    Murray, J.R.; Segall, P.

    2005-01-01

    In 1993 several baselines of the two-color electronic distance meter (EDM) network at Parkfield, California, deviated from their long-term rates, coincident with anomalous observations from nearby strain meters and a creep meter, as well as an increase in microseismicity. Between October 1992 and December 1994, three M ??? 4.5 earthquakes occurred beneath Middle Mountain, near the hypocenter of the 1934 and 1966 Parkfield M6 events. We analyzed the two-color EDM data using a Kalman-filtering based technique to image the spatiotemporal evolution of slip on the fault at Parkfield between the mid-1980s and 2003. This method accounts for localized random walk motion of the geodetic monuments and a prominent seasonal signal that affects many baselines. We find that a slip rate increase occurred between January 1993 and July 1996 on the upper 8 km of the fault near Middle Mountain. The peak estimated slip rate during this time was 49 mm/yr, which exceeds the long-term geologic rate of ???35 mm/yr. The slip rate evolution appears episodic, with an initial modest increase after the M4.3 earthquake and a much larger jump following the shallower M4.7 event in December 1994. This temporal correlation between inferred slip and seismicity suggests that the moderate earthquakes triggered the aseismic fault slip. The EDM data cannot resolve whether transient slip propagated across the nucleation zone of the 1934 and 1966 M6 Parkfield earthquakes. However, transient slip and its associated stress release in the hypocentral area of previous Parkfield events is consistent with the nucleation of the 2004 M6 Parkfield earthquake elsewhere on the fault. Copyright 2005 by the American Geophysical Union.

  1. Enabling Near Real-Time Remote Search for Fast Transient Events with Lossy Data Compression

    NASA Astrophysics Data System (ADS)

    Vohl, Dany; Pritchard, Tyler; Andreoni, Igor; Cooke, Jeffrey; Meade, Bernard

    2017-09-01

    We present a systematic evaluation of JPEG2000 (ISO/IEC 15444) as a transport data format to enable rapid remote searches for fast transient events as part of the Deeper Wider Faster programme. Deeper Wider Faster programme uses 20 telescopes from radio to gamma rays to perform simultaneous and rapid-response follow-up searches for fast transient events on millisecond-to-hours timescales. Deeper Wider Faster programme search demands have a set of constraints that is becoming common amongst large collaborations. Here, we focus on the rapid optical data component of Deeper Wider Faster programme led by the Dark Energy Camera at Cerro Tololo Inter-American Observatory. Each Dark Energy Camera image has 70 total coupled-charged devices saved as a 1.2 gigabyte FITS file. Near real-time data processing and fast transient candidate identifications-in minutes for rapid follow-up triggers on other telescopes-requires computational power exceeding what is currently available on-site at Cerro Tololo Inter-American Observatory. In this context, data files need to be transmitted rapidly to a foreign location for supercomputing post-processing, source finding, visualisation and analysis. This step in the search process poses a major bottleneck, and reducing the data size helps accommodate faster data transmission. To maximise our gain in transfer time and still achieve our science goals, we opt for lossy data compression-keeping in mind that raw data is archived and can be evaluated at a later time. We evaluate how lossy JPEG2000 compression affects the process of finding transients, and find only a negligible effect for compression ratios up to 25:1. We also find a linear relation between compression ratio and the mean estimated data transmission speed-up factor. Adding highly customised compression and decompression steps to the science pipeline considerably reduces the transmission time-validating its introduction to the Deeper Wider Faster programme science pipeline and

  2. Transient analysis of a flywheel battery containment during a full rotor burst event.

    SciTech Connect

    Hsieh, B. J.

    1998-04-17

    Flywheels are being developed for use in an Advanced Locomotive Propulsion System (ALPS) targeted for use in high speed passenger rail service. The ALPS combines high performance, high speed gas turbines, motor/generators and flywheels to provide a light-weight, fuel-efficient power system. Such a system is necessary to avoid the high cost of railway electrification, as is currently done for high speed rail service (>100mph) since diesels are too heavy. The light-weight flywheel rotors are made from multilayered composite materials, and are operated at extremely high energy levels. Metal containment structures have been designed to enclose the rotors and provide encapsulation of the rotor during postulated failure events. One such event is a burst mode failure of the rotor in which the composite rim is assumed to burst into debris that impacts against the containment. This paper presents a finite element simulation of the transient structural response of a subscale metal flywheel containment structure to a rotor burst event.

  3. Single Event Transients in Voltage Regulators for FPGA Power Supply Applications

    NASA Technical Reports Server (NTRS)

    Poivey, Christian; Sanders, Anthony; Kim, Hak; Phan, Anthony; Forney, Jim; LaBel, Kenneth A.; Karsh, Jeremy; Pursley, Scott; Kleyner, Igor; Katz, Richard

    2006-01-01

    As with other bipolar analog devices, voltage regulators are known to be sensitive to single event transients (SET). In typical applications, large output capacitors are used to provide noise immunity. Therefore, since SET amplitude and duration are generally small, they are often of secondary importance due to this capacitance filtering. In low voltage applications, however, even small SET are a concern. Over-voltages may cause destructive conditions. Under-voltages may cause functional interrupts and may also trigger electrical latchup conditions. In addition, internal protection circuits which are affected by load as well as internal thermal effects can also be triggered from heavy ions, causing dropouts or shutdown ranging from milliseconds to seconds. In the case of FPGA power supplies applications, SETS are critical. For example, in the case of Actel FPGA RTAX family, core power supply voltage is 1.5V. Manufacturer specifies an absolute maximum rating of 1.6V and recommended operating conditions between 1.425V and 1.575V. Therefore, according to the manufacturer, any transient of amplitude greater than 75 mV can disrupt normal circuit functions, and overvoltages greater than 100 mV may damage the FPGA. We tested five low dropout voltage regulators for SET sensitivity under a large range of circuit application conditions.

  4. Image analysis of single event transient effects on charge coupled devices irradiated by protons

    NASA Astrophysics Data System (ADS)

    Wang, Zujun; Xue, Yuanyuan; Liu, Jing; He, Baoping; Yao, Zhibin; Ma, Wuying

    2016-10-01

    The experiments of single event transient (SET) effects on charge coupled devices (CCDs) irradiated by protons are presented. The radiation experiments have been carried out at the accelerator protons with the energy of 200 MeV and 60 MeV.The incident angles of the protons are at 30°and 90° to the plane of the CCDs to obtain the images induced by the perpendicularity and incline incident angles. The experimental results show that the typical characteristics of the SET effects on a CCD induced by protons are the generation of a large number of dark signal spikes (hot pixels) which are randomly distributed in the "pepper" images. The characteristics of SET effects are investigated by observing the same imaging area at different time during proton radiation to verify the transient effects. The experiment results also show that the number of dark signal spikes increases with increasing integration time during proton radiation. The CCDs were tested at on-line and off-line to distinguish the radiation damage induced by the SET effects or DD effects. The mechanisms of the dark signal spike generation induced by the SET effects and the DD effects are demonstrated respectively.

  5. Studies on the high-energy follow-up of gravitational wave transient events

    NASA Astrophysics Data System (ADS)

    Razzano, Massimiliano; Patricelli, Barbara; Cella, Giancarlo; Fidecaro, Francesco; Pian, Elena; Stamerra, Antonio; Branchesi, Marica

    2016-05-01

    Second-generation gravitational wave interferometers, such as Advanced LIGO and Advanced Virgo, will soon reach sensitivities sufficient to first detect gravitational waves and open a new era in the multi-messenger investigations of the cosmos. The most violent and energetic astrophysical phenomena, including the mergers of compact objects or the core collapse of massive stars, are promising sources of gravitational waves, and are thought to be connected with transient phenomena such as Gamma Ray Bursts and supernovae. Combined observations of gravitational and electromagnetic signals from these events will thus provide a unique opportunity to unveil their progenitors and study the physics of compact objects. In particular, gamma-ray ground-based and space observatories such as Fermi or the Air Cherenkov Telescopes will be crucial to observe the high-energy electromagnetic counterparts of transient gravitational wave signals and provide a robust identification based on a precise sky localization. We will report on our studies of possible joint observation strategies carried on by gravitational interferometers and gamma-ray telescopes, with particular attention to the high-energy follow-up of Gamma Ray Bursts.

  6. The Pan-STARRS Survey for Transients (PSST) and the search for optical /ir counterparts to LIGO events

    NASA Astrophysics Data System (ADS)

    Carter Chambers, Kenneth; Smartt, Stephen; Huber, Mark; Flewelling, Heather

    2015-08-01

    The advanced LIGO array is expected to have its first observing runs in 2015. The error regions of the first year of operations are expected to be several hundred square degrees. The optimal optical/ir survey for counterparts to graviational wave events would constantly survey the sky such that the prior state of the sky was known just before a gravitational wave event.The Pan-STARRS Survey for Transients (PSST) as part of the Pan-STARRS NEO Survey will be able to use both the ongoing static sky observed as part ot the NEO survey, but also the prior Pan-STARRS1 3pi sky survey as a template for the background sky. Upon receiving alerts from LIGO, Pan-STARRS (PS1 and PS2) will map the regions as determined by LIGO. The area is so large it may contain a large number of normally occuring transient events that are unrelated to the LIGO event. The PSST, with followup using UH telescopes will attempt to target all the transients detected by Pan-STARRS to determine their light curves and when possible their spectra to identify the most likely candidates for counterparts to LIGO events.The Pan-STARRS NEO Survey and the Pan-STARRS Survey for Transients will be discussed together with results from recent transient detections.

  7. Towards an Automated Classification of Transient Events in Synoptic Sky Surveys

    NASA Technical Reports Server (NTRS)

    Djorgovski, S. G.; Donalek, C.; Mahabal, A. A.; Moghaddam, B.; Turmon, M.; Graham, M. J.; Drake, A. J.; Sharma, N.; Chen, Y.

    2011-01-01

    We describe the development of a system for an automated, iterative, real-time classification of transient events discovered in synoptic sky surveys. The system under development incorporates a number of Machine Learning techniques, mostly using Bayesian approaches, due to the sparse nature, heterogeneity, and variable incompleteness of the available data. The classifications are improved iteratively as the new measurements are obtained. One novel featrue is the development of an automated follow-up recommendation engine, that suggest those measruements that would be the most advantageous in terms of resolving classification ambiguities and/or characterization of the astrophysically most interesting objects, given a set of available follow-up assets and their cost funcations. This illustrates the symbiotic relationship of astronomy and applied computer science through the emerging disciplne of AstroInformatics.

  8. Towards an Automated Classification of Transient Events in Synoptic Sky Surveys

    NASA Technical Reports Server (NTRS)

    Djorgovski, S. G.; Donalek, C.; Mahabal, A. A.; Moghaddam, B.; Turmon, M.; Graham, M. J.; Drake, A. J.; Sharma, N.; Chen, Y.

    2011-01-01

    We describe the development of a system for an automated, iterative, real-time classification of transient events discovered in synoptic sky surveys. The system under development incorporates a number of Machine Learning techniques, mostly using Bayesian approaches, due to the sparse nature, heterogeneity, and variable incompleteness of the available data. The classifications are improved iteratively as the new measurements are obtained. One novel featrue is the development of an automated follow-up recommendation engine, that suggest those measruements that would be the most advantageous in terms of resolving classification ambiguities and/or characterization of the astrophysically most interesting objects, given a set of available follow-up assets and their cost funcations. This illustrates the symbiotic relationship of astronomy and applied computer science through the emerging disciplne of AstroInformatics.

  9. First Ground-based Observation of Transient Luminous Events over Southern Africa

    NASA Astrophysics Data System (ADS)

    Nnadih, Ogechukwu; Kosch, Michael; Martinez, Peter

    2016-07-01

    We present the first ground-based observations in southern Africa of Transient Luminous Events (TLEs) in the summer of 2015/16 over convective thunderstorms. For the months of December to February, South Africa has one of the highest lightning stroke rates in the world. This was part of the AfriSprite campaign initiated by the South African National Space Agency. These observations show a variety of fine structures such as tree-like shaped, carrot, angel and jellyfish-shaped sprites. The South African Weather Service array of VLF receivers is used to locate and quantify the magnitude and polarity of the lightning strikes associated with TLEs. We plan to make bi-static as well as multi-wavelength observations in future.

  10. Characteristics of Thunderstorms and Lightning Flashes Which Produce Mesospheric Transient Luminous Events

    NASA Technical Reports Server (NTRS)

    Lyons, W. A.; Nelson, T. E.; Armstrong, R. A.; Williams, E. R.; Suszcynsky, D. M.; Strabley, R.; Taylor, M.; Gardner, L.

    1999-01-01

    A six year record of optical observations of lightning-induced mesospheric transient luminous events (TLEs) is available from the Yucca Ridge Field Station (YRFS) near Ft. Collins, CO. Climatological analyses reveal sprites and elves occur in a variety of convective storm types, but principally mesoscale convective systems (MCSs) and squall lines. Severe supercell storms rarely produce TLEs, except during their dissipating stage. Few TLEs are observed during storms with radar echo areas <7,500 sq km. Above this size there is a modest correlation with radar areal coverage. A typical High Plains storm produces 45 TLEs over a 143 interval. Sprites and most elves are associated with +CGs. The probability of a TLE increases with peak current. In six storms, 5.1% of +CGs produced TLEs, the number increasing to 32% of +CGs with >75 kA and 52% of +CGs with >100 kA peak current.

  11. Erosion of tungsten armor after multiple intense transient events in ITER

    NASA Astrophysics Data System (ADS)

    Bazylev, B. N.; Janeschitz, G.; Landman, I. S.; Pestchanyi, S. E.

    2005-03-01

    Macroscopic erosion by melt motion is the dominating damage mechanism for tungsten armour under high-heat loads with energy deposition W > 1 MJ/m 2 and τ > 0.1 ms. For ITER divertor armour the results of a fluid dynamics simulation of the melt motion erosion after repetitive stochastically varying plasma heat loads of consecutive disruptions interspaced by ELMs are presented. The heat loads for particular single transient events are numerically simulated using the two-dimensional MHD code FOREV-2D. The whole melt motion is calculated by the fluid dynamics code MEMOS-1.5D. In addition for the ITER dome melt motion erosion of tungsten armour caused by the lateral radiation impact from the plasma shield at the disruption and ELM heat loads is estimated.

  12. Vapor shielding models and the energy absorbed by divertor targets during transient events

    NASA Astrophysics Data System (ADS)

    Skovorodin, D. I.; Pshenov, A. A.; Arakcheev, A. S.; Eksaeva, E. A.; Marenkov, E. D.; Krasheninnikov, S. I.

    2016-02-01

    The erosion of divertor targets caused by high heat fluxes during transients is a serious threat to ITER operation, as it is going to be the main factor determining the divertor lifetime. Under the influence of extreme heat fluxes, the surface temperature of plasma facing components can reach some certain threshold, leading to an onset of intense material evaporation. The latter results in formation of cold dense vapor and secondary plasma cloud. This layer effectively absorbs the energy of the incident plasma flow, turning it into its own kinetic and internal energy and radiating it. This so called vapor shielding is a phenomenon that may help mitigating the erosion during transient events. In particular, the vapor shielding results in saturation of energy (per unit surface area) accumulated by the target during single pulse of heat load at some level Emax. Matching this value is one of the possible tests to verify complicated numerical codes, developed to calculate the erosion rate during abnormal events in tokamaks. The paper presents three very different models of vapor shielding, demonstrating that Emax depends strongly on the heat pulse duration, thermodynamic properties, and evaporation energy of the irradiated target material. While its dependence on the other shielding details such as radiation capabilities of material and dynamics of the vapor cloud is logarithmically weak. The reason for this is a strong (exponential) dependence of the target material evaporation rate, and therefore the "strength" of vapor shield on the target surface temperature. As a result, the influence of the vapor shielding phenomena details, such as radiation transport in the vapor cloud and evaporated material dynamics, on the Emax is virtually completely masked by the strong dependence of the evaporation rate on the target surface temperature. However, the very same details define the amount of evaporated particles, needed to provide an effective shielding to the target, and

  13. Coronal Transient Events During Two Solar Minima: Their Solar Source Regions and Interplanetary Counterparts

    NASA Astrophysics Data System (ADS)

    Cremades, H.; Mandrini, C. H.; Dasso, S.

    2011-12-01

    In the frame of two coordinated observational and research efforts, two full solar rotations were investigated in the times of two distinct solar minima. These two campaigns were dubbed Whole Sun Month (WSM; 10 August - 8 September 1996) and Whole Heliosphere Interval (WHI; 20 March - 16 April 2008). The nearly uninterrupted gathering of solar coronal data since the beginning of the Solar and Heliospheric Observatory (SOHO) era offers the exceptional possibility of comparing two solar minima for the first time, with regard to the coronal transient aspect. This study characterizes the variety of outward-traveling transients observed in the solar corona during both time intervals, from very narrow jet-like events to coronal mass ejections (CMEs). Their solar source regions and ensuing interplanetary structures were identified and characterized as well, toward a global-scale description of their role in determining the heliosphere’s conditions. Multi-wavelength images provided by the space missions SOHO, Yohkoh (only WSM), and Solar-Terrestrial Relations Observatory (STEREO; only WHI) and ground-based observatories were analyzed for coronal ejecta and their solar sources, while data registered by the Advanced Composition Explorer (ACE) spacecraft were inspected for interplanetary CMEs and magnetic clouds. Notable differences arise from the analysis of the detailed survey of events: more (fewer) ejecta during WHI (WSM), 12% (40%) were produced by active regions during WHI (WSM), and nearly no (high) deflection from the radial direction was observed during WHI (WSM). Instrumental aspects such as dissimilar resolution, cadence, and fields of view are considered in order to discern instrumentally driven disparities from inherent differences between solar minima.

  14. A New Type of Transient Luminous Events Produced by Terrestrial Gamma-ray Flashes

    NASA Astrophysics Data System (ADS)

    Xu, W.; Celestin, S. J.; Pasko, V. P.; Marshall, R. A.

    2016-12-01

    Discovered in 1994 by the Burst and Transient Source Experiment (BATSE) detector aboard the Compton Gamma-Ray Observatory [Fishman et al., Science, 264, 1313, 1994], Terrestrial Gamma-ray Flashes (TGFs) are high-energy photon bursts originating from the Earth's atmosphere characterized by their close association with thunderstorm activities. Since the discovery, TGFs have also been observed by the Reuven Ramaty High Energy Solar Spectroscopic Imager (RHESSI) [Smith et al., Science, 307, 1085, 2005], the Fermi Gamma-ray Space Telescope [Briggs et al., JGR, 115, A07323, 2010], and the Astrorivelatore Gamma a Immagini Leggero (AGILE) satellite [Marisaldi et al., JGR, 115, A00E13, 2010]. Space-borne measurements have revealed the temporal and spectral features of TGFs: typically lasting from fractions of to a few milliseconds, having a fluence of fractions of photons/cm2, and exhibiting a hard energy spectra extending up to a few tens of MeVs [Dwyer et al., Space Sci. Rev., 173, 133, 2012]. Moreover, detailed analyses of radio emissions have pointed out the close correlation between TGFs and the initial development stages of normal polarity intra-cloud lightning that transports negative charge upward (+IC) [e.g., Lu et al., GRL, 37, L11806, 2010; JGR, 116, A03316, 2011]. In this work, we show that, while TGFs pass through the atmosphere, the large quantities of energetic electrons knocked out during collisions of gamma-rays with air molecules can generate significant amount of excited species of neutral and ionized nitrogen molecules, thereby leading to production of a new type of transient luminous events (TLEs). The spectroscopic and morphological features of this predicted luminous phenomenon have been theoretically quantified in the framework of Monte Carlo simulations. Considering the measurability of this type of events and its close relation with TGFs, corresponding measurements would provide a novel perspective to investigate TGFs, as well as the initial

  15. Investigations on heavy ion induced Single-Event Transients (SETs) in highly-scaled FinFETs

    NASA Astrophysics Data System (ADS)

    Gaillardin, M.; Raine, M.; Paillet, P.; Adell, P. C.; Girard, S.; Duhamel, O.; Andrieu, F.; Barraud, S.; Faynot, O.

    2015-12-01

    We investigate Single-Event Transients (SET) in different designs of multiple-gate devices made of FinFETs with various geometries. Heavy ion experimental results are explained by using a thorough charge collection analysis of fast transients measured on dedicated test structures. Multi-level simulations are performed to get new insights into the charge collection mechanisms in multiple-gate devices. Implications for multiple-gate device design hardening are finally discussed.

  16. Comparison of Above Bandgap Laser and MeV Ion Induced Single Event Transients in High-Speed Si Photonic Devices

    NASA Technical Reports Server (NTRS)

    Laird, Jamie S.; Hirao, Toshio; Onoda, Shinobu; Itoh, Hisayoshi; Edmonds, Larry; Johnston, Allan

    2006-01-01

    We illustrate inherent differences between Single Event Transients generated by an above bandgap picosecond lasers and MeV heavy ions by comparing transient currents collected with an ion microbeam and picosecond laser with varying track waist.

  17. Comparison of Above Bandgap Laser and MeV Ion Induced Single Event Transients in High-Speed Si Photonic Devices

    NASA Technical Reports Server (NTRS)

    Laird, Jamie S.; Hirao, Toshio; Onoda, Shinobu; Itoh, Hisayoshi; Edmonds, Larry; Johnston, Allan

    2006-01-01

    We illustrate inherent differences between Single Event Transients generated by an above bandgap picosecond lasers and MeV heavy ions by comparing transient currents collected with an ion microbeam and picosecond laser with varying track waist.

  18. Identifying the occurrence of lightning and transient luminous events by nadir spectrophotometric observation

    NASA Astrophysics Data System (ADS)

    Adachi, Toru; Sato, Mitsuteru; Ushio, Tomoo; Yamazaki, Atsushi; Suzuki, Makoto; Kikuchi, Masayuki; Takahashi, Yukihiro; Inan, Umran S.; Linscott, Ivan; Hobara, Yasuhide; Frey, Harald U.; Mende, Stephen B.; Chen, Alfred B.; Hsu, Rue-Ron; Kusunoki, Kenichi

    2016-07-01

    We propose a new technique to identify the occurrence of lightning and transient luminous events (TLEs) using multicolor photometric data obtained by space borne nadir measurements. We estimate the spectral characteristics of lightning and TLEs by converting the optical data obtained by the ISUAL limb experiment to the GLIMS nadir geometry. We find that the estimated spectral shapes of TLE-accompanied lightning are clearly different from those of pure lightning. The obtained results show that (1) the intensity of FUV signals and (2) the ratio of 337/red (609-753 nm) spectral irradiance are useful to identify the occurrence of TLEs. The occurrence probabilities of TLEs are 10%, 40%, 80%, in the case of lightning events having the 337/red spectral irradiance ratio of 0.95, 2.95, 14.79, respectively. By using the 60% criterion of the 337/red ratio and the existence of FUV emissions, we classify the 1039 GLIMS-observed lightning events into 828 pure lightning and 211 TLE-accompanied lightning. Since the GLIMS trigger level is adjusted to observe extremely-bright events, the occurrence probability of TLEs obtained here most probably reflects the characteristics of energetic lightning. The estimated global map is consistent with previously determined distributions: the highest activities of lightning and TLEs are found over the North/South American continents, African continent, and Asian maritime regions. While the absolute occurrence number of pure lightning and TLE-accompanied lightning are found to maximize in the equatorial region, the occurrence probability of TLEs possibly increase somewhat in the mid-latitude region. Since the occurrence probabilities of TLEs are higher over the ocean than over land, it is likely that the GLIMS-observed TLEs are due primarily to elves which tends to occur more frequently over the ocean.

  19. A 'transient' automated mapping procedure for complex geometries

    NASA Technical Reports Server (NTRS)

    Raad, Peter E.; White, James W.

    1988-01-01

    A numerical procedure is presented which is applicable to the general curvilinear mappings of complex geometries and is unrestricted by slow convergence or strong dependence on the initial conditions of physical space. The scheme, employing a time-dependent factored-implicit scheme, is shown to be general and robust. In the illustrative applications presented, complex, closed geometries are routinely mapped even when they begin with unreasonable initial conditions created through the analytical and computer graphics inputs. Due to the natural damping introduced into the governing equations, fast convergence is achieved and high stability is observed.

  20. Prediction of cardiac events in patients with transient left ventricle dilation on stress myocardial perfusion SPECT images.

    PubMed

    Fukuda, Hiroshi; Moroi, Masao

    2005-10-01

    The purpose of this study was to investigate cardiac events in patients with transient left ventricle (LV) dilation on stress myocardial perfusion single-photon emission computed tomography images (MPI). Consecutive patients (n=53, 31 males, mean age 71 years) with transient LV dilation on thallium-201 stress MPI (treadmill: 21, pharmacologic: 32) were followed for 17 months. Follow-up time was censored at the occurrence of cardiac death, congestive heart failure, acute coronary syndrome, or revascularization. Images were scored and then the summed stress score (SSS), summed rest score, and summed difference score were calculated. Cardiac death occurred in 3 patients, hospitalization occurred in 8 patients, and revascularization occurred in 20 patients. The combined cardiac event rate was 59% (76% for exercise stress vs 47% for pharmacologic stress, p=0.034). Cox regression analysis demonstrated that a combination of higher SSS and slow washout rate was the best predictor of cardiac events (hazard ratio =3.3, p=0.029). A high cardiac event rate is associated with transient LV dilation on thallium-201 stress MPI. The event rate is particularly high for exercise stress MPI. Furthermore, a combination of the SSS and thallium-201 slow washout is the best predictor of cardiac events in patients with transient LV dilation.

  1. Single event transient modeling and mitigation techniques for mixed-signal delay locked loop (DLL) and clock circuits

    NASA Astrophysics Data System (ADS)

    Maillard, Pierre

    The purpose of this PhD work has been to investigate, model, test, develop and provide hardening techniques and guidelines for the mitigation of single event transients (SETs) in analog mixed-signal (AMS) delay locked loops (DLLs) for radiation-hardened applications. Delay-locked-loops (DLLs) are circuit substructures that are present in complex ASIC and system-on-a-chip designs. These circuits are widely used in on-chip clock distribution systems to reduce clock skew, to reduce jitter noise, and to recover clock signals at regional points within a global clock distribution system. DLLs are critical to the performance of many clock distribution systems, and in turn, the overall performance of the associated integrated system; as such, complex systems often employ multiple DLLs for clock deskew and distribution tasks. In radiation environments such as on-orbit, these critical circuits represent at-risk points of malfunction for large sections of integrated circuits due to vulnerabilities to radiation-generated transients (i.e. single event transients) that fan out across the system. The analysis of single event effects in analog DLLs has shown that each DLL sub-circuit primitive is vulnerable to single event transients. However, we have identified the voltage controlled delay line (VCDL) sub-circuit as the most sensitive to radiation-induced single event effects generating missing clock pulses that increase with the operating frequency of the circuit. This vulnerability increases with multiple instantiation of DLLs as clock distribution nodes throughout an integrated system on a chip. To our knowledge, no complete work in the rad-hard community regarding the hardening of mixed-signal DLLs against single event effects (missing pulses) has been developed. Most of the work present in the literature applies the "brute force" and well-established digital technique of triple modular redundancy (TMR) to the digital subcomponents. We have developed two novel design

  2. Energy deprivation transiently enhances rhythmic inhibitory events in the CA3 hippocampal network in vitro.

    PubMed

    Gee, C E; Benquet, P; Demont-Guignard, S; Wendling, F; Gerber, U

    2010-07-14

    Oxygen glucose deprivation (OGD) leads to rapid suppression of synaptic transmission. Here we describe an emergence of rhythmic activity at 8 to 20 Hz in the CA3 subfield of hippocampal slice cultures occurring for a few minutes prior to the OGD-induced cessation of evoked responses. These oscillations, dominated by inhibitory events, represent network activity, as they were abolished by tetrodotoxin. They were also completely blocked by the GABAergic antagonist picrotoxin, and strongly reduced by the glutamatergic antagonist NBQX. Applying CPP to block NMDA receptors had no effect and neither did UBP302, an antagonist of GluK1-containing kainate receptors. The gap junction blocker mefloquine disrupted rhythmicity. Simultaneous whole-cell voltage-clamp recordings from neighboring or distant CA3 pyramidal cells revealed strong cross-correlation of the incoming rhythmic activity. Interneurons in the CA3 area received similar correlated activity. Interestingly, oscillations were much less frequently observed in the CA1 area. These data, together with the observation that the recorded activity consists primarily of inhibitory events, suggest that CA3 interneurons are important for generating these oscillations. This transient increase in inhibitory network activity during OGD may represent a mechanism contributing to the lower vulnerability to ischemic insults of the CA3 area as compared to the CA1 area.

  3. The HAWC Real-time Flare Monitor for Rapid Detection of Transient Events

    NASA Astrophysics Data System (ADS)

    Abeysekara, A. U.; Alfaro, R.; Alvarez, C.; Álvarez, J. D.; Arceo, R.; Arteaga-Velázquez, J. C.; Avila Rojas, D.; Ayala Solares, H. A.; Barber, A. S.; Bautista-Elivar, N.; Becerra Gonzalez, J.; Becerril, A.; Belmont-Moreno, E.; BenZvi, S. Y.; Bernal, A.; Braun, J.; Brisbois, C.; Caballero-Mora, K. S.; Capistrán, T.; Carramiñana, A.; Casanova, S.; Castillo, M.; Cotti, U.; Cotzomi, J.; Coutiño de León, S.; De la Fuente, E.; De León, C.; Díaz-Vélez, J. C.; Dingus, B. L.; DuVernois, M. A.; Ellsworth, R. W.; Engel, K.; Fiorino, D. W.; Fraija, N.; García-González, J. A.; Garfias, F.; Gerhardt, M.; González, M. M.; González Muñoz, A.; Goodman, J. A.; Hampel-Arias, Z.; Harding, J. P.; Hernandez, S.; Hernandez-Almada, A.; Hona, B.; Hui, C. M.; Hüntemeyer, P.; Iriarte, A.; Jardin-Blicq, A.; Joshi, V.; Kaufmann, S.; Kieda, D.; Lauer, R. J.; Lee, W. H.; Lennarz, D.; León Vargas, H.; Linnemann, J. T.; Longinotti, A. L.; López-Cámara, D.; López-Coto, R.; Raya, G. Luis; Luna-García, R.; Malone, K.; Marinelli, S. S.; Martinez, O.; Martinez-Castellanos, I.; Martínez-Castro, J.; Martínez-Huerta, H.; Matthews, J. A.; Miranda-Romagnoli, P.; Moreno, E.; Mostafá, M.; Nellen, L.; Newbold, M.; Nisa, M. U.; Noriega-Papaqui, R.; Pelayo, R.; Pérez-Pérez, E. G.; Pretz, J.; Ren, Z.; Rho, C. D.; Rivière, C.; Rosa-González, D.; Rosenberg, M.; Ruiz-Velasco, E.; Salazar, H.; Salesa Greus, F.; Sandoval, A.; Schneider, M.; Schoorlemmer, H.; Sinnis, G.; Smith, A. J.; Springer, R. W.; Surajbali, P.; Taboada, I.; Tibolla, O.; Tollefson, K.; Torres, I.; Ukwatta, T. N.; Vianello, G.; Weisgarber, T.; Westerhoff, S.; Wisher, I. G.; Wood, J.; Yapici, T.; Younk, P. W.; Zepeda, A.; Zhou, H.

    2017-07-01

    We present the development of a real-time flare monitor for the High Altitude Water Cherenkov (HAWC) observatory. The flare monitor has been fully operational since 2017 January and is designed to detect very high energy (VHE; E ≳ 100 GeV) transient events from blazars on timescales lasting from 2 minutes to 10 hr in order to facilitate multiwavelength and multimessenger studies. These flares provide information for investigations into the mechanisms that power the blazars’ relativistic jets and accelerate particles within them, and they may also serve as probes of the populations of particles and fields in intergalactic space. To date, the detection of blazar flares in the VHE range has relied primarily on pointed observations by imaging atmospheric Cherenkov telescopes. The recently completed HAWC observatory offers the opportunity to study VHE flares in survey mode, scanning two-thirds of the entire sky every day with a field of view of ∼1.8 steradians. In this work, we report on the sensitivity of the HAWC real-time flare monitor and demonstrate its capabilities via the detection of three high-confidence VHE events in the blazars Markarian 421 and Markarian 501.

  4. Transient Kluver-Bucy syndrome following complex partial status epilepticus.

    PubMed

    Varon, Daniel; Pritchard, Paul B; Wagner, Mark T; Topping, Kris

    2003-06-01

    The characteristic features of Kluver-Bucy syndrome include hypersexuality, hyperorality, placidity, hypermetamorphosis, visual agnosia, changes in dietary habits, and memory impairment. Human cases have been reported with herpes simplex encephalitis, head injury, Pick's disease, transtentorial herniation, adrenoleukodystrophy, and Reye's syndrome, all involving bilateral temporal lobe pathology. We present the case of a patient with no evidence of a structural lesion in the temporal lobes and behavioral changes consistent with Kluver-Bucy syndrome following complex partial status epilepticus.

  5. Transient Galactic Cosmic-ray Modulation during Solar Cycle 24: A Comparative Study of Two Prominent Forbush Decrease Events

    NASA Astrophysics Data System (ADS)

    Zhao, L.-L.; Zhang, H.

    2016-08-01

    Forbush decrease (FD) events are of great interest for transient galactic cosmic-ray (GCR) modulation study. In this study, we perform comparative analysis of two prominent Forbush events during cycle 24, occurring on 2012 March 8 (Event 1) and 2015 June 22 (Event 2), utilizing the measurements from the worldwide neutron monitor (NM) network. Despite their comparable magnitudes, the two Forbush events are distinctly different in terms of evolving GCR energy spectrum and energy dependence of the recovery time. The recovery time of Event 1 is strongly dependent on the median energy, compared to the nearly constant recovery time of Event 2 over the studied energy range. Additionally, while the evolutions of the energy spectra during the two FD events exhibit similar variation patterns, the spectrum of Event 2 is significantly harder, especially at the time of deepest depression. These difference are essentially related to their associated solar wind disturbances. Event 1 is associated with a complicated shock-associated interplanetary coronal mass ejection (ICME) disturbance with large radial extent, probably formed by the merging of multiple shocks and transient flows, and which delivered a glancing blow to Earth. Conversely, Event 2 is accompanied by a relatively simple halo ICME with small radial extent that hit Earth more head-on.

  6. Optimal control of transient dynamics in balanced networks supports generation of complex movements.

    PubMed

    Hennequin, Guillaume; Vogels, Tim P; Gerstner, Wulfram

    2014-06-18

    Populations of neurons in motor cortex engage in complex transient dynamics of large amplitude during the execution of limb movements. Traditional network models with stochastically assigned synapses cannot reproduce this behavior. Here we introduce a class of cortical architectures with strong and random excitatory recurrence that is stabilized by intricate, fine-tuned inhibition, optimized from a control theory perspective. Such networks transiently amplify specific activity states and can be used to reliably execute multidimensional movement patterns. Similar to the experimental observations, these transients must be preceded by a steady-state initialization phase from which the network relaxes back into the background state by way of complex internal dynamics. In our networks, excitation and inhibition are as tightly balanced as recently reported in experiments across several brain areas, suggesting inhibitory control of complex excitatory recurrence as a generic organizational principle in cortex. Copyright © 2014 Elsevier Inc. All rights reserved.

  7. Ten-year transient luminous events and Earth observations of FORMOSAT-2

    NASA Astrophysics Data System (ADS)

    Chern, Rock Jeng-Shing; Lin, Shin-Fa; Wu, An-Ming

    2015-07-01

    The purpose of this paper is to summarize the enormous contributions of FS2 (FORMOSAT-2 or Formosa satellite #2) in both Earth and transient luminous events (TLEs) observations in 10 years. As a small satellite operated for 10 years (20 May 2004 to 20 May 2014) in orbit, FS2 keeps its two unique characteristics: (1) to orbit 14 revolutions around the Earth per day with daily revisit capability, and (2) to provide the capabilities of Earth observation in sunlight time and TLEs observation in eclipsed time every day. It carries two payloads: the remote sensing instrument (RSI) for Earth imaging in satellite's day time and the imager of sprites and upper atmospheric lightning instrument (ISUAL) for scientific observations in satellite's night time, respectively. Daily revisit capability provides changes of events on Earth in either short time (several days) or long term (several years). Examples include: Indian Ocean earthquake and tsunami (December 2004), disintegration of Wilkins Ice Shelf in Antarctica region (2006-2014, long term), Sichuan earthquake (May 2008), Tohoku earthquake and tsunami (March 2011), polar regions (2006-2014, long term), etc. In the TLEs observation, ISUAL had recorded more than 35,000 events in 10 years with 73.93% elves, 6.54% red sprites, 5.81% halos, 13.42% blue jets and 0.30% gigantic jets. Major contributions of FS2 in this specific scientific area are presented. In particular, current and future research topics on TLEs are discussed. Also, major contributions of FS2's RSI to the United Nations Institute for Training and Research (UNITAR) Operational Satellite Applications Programme (UNOSAT) and Group of Earth Observation System of Systems (GEOSS) are summarized. This paper also addresses briefly the health status of FS2 after working 10 years in orbit.

  8. Complex event extraction at PubMed scale

    PubMed Central

    Björne, Jari; Ginter, Filip; Pyysalo, Sampo; Tsujii, Jun'ichi; Salakoski, Tapio

    2010-01-01

    Motivation: There has recently been a notable shift in biomedical information extraction (IE) from relation models toward the more expressive event model, facilitated by the maturation of basic tools for biomedical text analysis and the availability of manually annotated resources. The event model allows detailed representation of complex natural language statements and can support a number of advanced text mining applications ranging from semantic search to pathway extraction. A recent collaborative evaluation demonstrated the potential of event extraction systems, yet there have so far been no studies of the generalization ability of the systems nor the feasibility of large-scale extraction. Results: This study considers event-based IE at PubMed scale. We introduce a system combining publicly available, state-of-the-art methods for domain parsing, named entity recognition and event extraction, and test the system on a representative 1% sample of all PubMed citations. We present the first evaluation of the generalization performance of event extraction systems to this scale and show that despite its computational complexity, event extraction from the entire PubMed is feasible. We further illustrate the value of the extraction approach through a number of analyses of the extracted information. Availability: The event detection system and extracted data are open source licensed and available at http://bionlp.utu.fi/. Contact: jari.bjorne@utu.fi PMID:20529932

  9. Total Dose Effects on Single Event Transients in Linear Bipolar Systems

    NASA Technical Reports Server (NTRS)

    Buchner, Stephen; McMorrow, Dale; Bernard, Muriel; Roche, Nicholas; Dusseau, Laurent

    2008-01-01

    Single Event Transients (SETs) originating in linear bipolar integrated circuits are known to undermine the reliability of electronic systems operating in the radiation environment of space. Ionizing particle radiation produces a variety of SETs in linear bipolar circuits. The extent to which these SETs threaten system reliability depends on both their shapes (amplitude and width) and their threshold energies. In general, SETs with large amplitudes and widths are the most likely to propagate from a bipolar circuit's output through a subsystem. The danger these SET pose is that, if they become latched in a follow-on circuit, they could cause an erroneous system response. Long-term exposure of linear bipolar circuits to particle radiation produces total ionizing dose (TID) and/or displacement damage dose (DDD) effects that are characterized by a gradual degradation in some of the circuit's electrical parameters. For example, an operational amplifier's gain-bandwidth product is reduced by exposure to ionizing radiation, and it is this reduction that contributes to the distortion of the SET shapes. In this paper, we compare SETs produced in a pristine LM124 operational amplifier with those produced in one exposed to ionizing radiation for three different operating configurations - voltage follower (VF), inverter with gain (IWG), and non-inverter with gain (NIWG). Each configuration produces a unique set of transient shapes that change following exposure to ionizing radiation. An important finding is that the changes depend on operating configuration; some SETs decrease in amplitude, some remain relatively unchanged, some become narrower and some become broader.

  10. A Luminous, Fast Rising UV-transient Discovered by ROTSE: A Tidal Disruption Event?

    NASA Astrophysics Data System (ADS)

    Vinkó, J.; Yuan, F.; Quimby, R. M.; Wheeler, J. C.; Ramirez-Ruiz, E.; Guillochon, J.; Chatzopoulos, E.; Marion, G. H.; Akerlof, C.

    2015-01-01

    We present follow-up observations of an optical transient (OT) discovered by ROTSE on 2009 January 21. Photometric monitoring was carried out with ROTSE-IIIb in the optical and Swift in the UV up to +70 days after discovery. The light curve showed a fast rise time of ~10 days followed by a steep decline over the next 60 days, which was much faster than that implied by 56Ni—56Co radioactive decay. The Sloan Digital Sky Survey Data Release 10 database contains a faint, red object at the position of the OT, which appears slightly extended. This and other lines of evidence suggest that the OT is of extragalactic origin, and this faint object is likely the host galaxy. A sequence of optical spectra obtained with the 9.2 m Hobby-Eberly Telescope between +8 and +45 days after discovery revealed a hot, blue continuum with no visible spectral features. A few weak features that appeared after +30 days probably originated from the underlying host. Fitting synthetic templates to the observed spectrum of the host galaxy revealed a redshift of z = 0.19. At this redshift, the peak magnitude of the OT is close to -22.5, similar to the brightest super-luminous supernovae; however, the lack of identifiable spectral features makes the massive stellar death hypothesis less likely. A more plausible explanation appears to be the tidal disruption of a Sun-like star by the central supermassive black hole. We argue that this transient likely belongs to a class of super-Eddington tidal disruption events.

  11. A LUMINOUS, FAST RISING UV-TRANSIENT DISCOVERED BY ROTSE: A TIDAL DISRUPTION EVENT?

    SciTech Connect

    Vinkó, J.; Wheeler, J. C.; Chatzopoulos, E.; Marion, G. H.; Yuan, F.; Akerlof, C.; Quimby, R. M.; Ramirez-Ruiz, E.; Guillochon, J.

    2015-01-01

    We present follow-up observations of an optical transient (OT) discovered by ROTSE on 2009 January 21. Photometric monitoring was carried out with ROTSE-IIIb in the optical and Swift in the UV up to +70 days after discovery. The light curve showed a fast rise time of ∼10 days followed by a steep decline over the next 60 days, which was much faster than that implied by {sup 56}Ni—{sup 56}Co radioactive decay. The Sloan Digital Sky Survey Data Release 10 database contains a faint, red object at the position of the OT, which appears slightly extended. This and other lines of evidence suggest that the OT is of extragalactic origin, and this faint object is likely the host galaxy. A sequence of optical spectra obtained with the 9.2 m Hobby-Eberly Telescope between +8 and +45 days after discovery revealed a hot, blue continuum with no visible spectral features. A few weak features that appeared after +30 days probably originated from the underlying host. Fitting synthetic templates to the observed spectrum of the host galaxy revealed a redshift of z = 0.19. At this redshift, the peak magnitude of the OT is close to –22.5, similar to the brightest super-luminous supernovae; however, the lack of identifiable spectral features makes the massive stellar death hypothesis less likely. A more plausible explanation appears to be the tidal disruption of a Sun-like star by the central supermassive black hole. We argue that this transient likely belongs to a class of super-Eddington tidal disruption events.

  12. Ischemic Transient Neurological Events Identified by Immune Response to Cerebral Ischemia

    PubMed Central

    Jickling, Glen C; Zhan, Xinhua; Stamova, Boryana; Ander, Bradley P; Tian, Yingfang; Liu, Dazhi; Sison, Shara-Mae; Verro, Piero; Johnston, S. Claiborne; Sharp, Frank R

    2012-01-01

    Background and Purpose Deciphering whether a transient neurological event (TNE) is of ischemic or nonischemic etiology can be challenging. Ischemia of cerebral tissue elicits an immune response in stroke and transient ischemic attack (TIA). This response, as detected by RNA expressed in immune cells, could potentially distinguish ischemic from nonischemic TNE. Methods Analysis of 208 TIAs, ischemic strokes, controls and TNE was performed. RNA from blood was processed on microarrays. TIAs (n=26) and ischemic strokes (n=94) were compared to controls (n=44) to identify differentially expressed genes (FDR<0.05, fold change ≥∣1.2∣). Genes common to TIA and stroke were used predict ischemia in TIA-DWI positive / minor-stroke (n=17), nonischemic TNE (n=13) and TNE of unclear etiology (n=14). Results Seventy-four genes expressed in TIA were common to those in ischemic stroke. Functional pathways common to TIA and stroke related to activation of innate and adaptive immune systems, involving granulocytes and B-cells. A prediction model using 26 of the 74 ischemia genes distinguished TIA and stroke subjects from controls with 89% sensitivity and specificity. In the validation cohort, 17/17 TIA-DWI positive / minor-strokes were predicted to be ischemic, and 10/13 nonischemic TNE were predicted to be nonischemic. In TNE of unclear etiology, 71% were predicted to be ischemic. These subjects had higher ABCD2 scores. Conclusions A common molecular response to ischemia in TIA and stroke was identified, relating to activation of innate and adaptive immune systems. TNE of ischemic etiology were identified based upon gene profiles that may be of clinical utility once validated. PMID:22308247

  13. Transient galactic cosmic ray modulation during solar cycle 24: A comparative study of two prominent Forbush decrease events

    NASA Astrophysics Data System (ADS)

    Lingling, Zhao; Huai, Zhang; Hongqing, He

    2016-04-01

    Forbush decrease (FD) events are of great interest for transient galactic cosmic ray modulation study. In this study, we perform statistical analysis of two prominent Forbush events during cycle 24, occurred on 8 March 2012 (Event 1) and 22 June 2015 (Event 2), respectively, utilizing the measurements from the worldwide neutron monitor (NM) network. Despite of their comparable magnitudes, the two Forbush events are distinctly different in terms of evolving GCR energy spectrum and energy dependence of the recovery time. The recovery time of Event 1 is strongly dependent on the median energy, compared to the nearly constant recovery time of Event 2 over the studied energy range. Additionally, while the evolution of the energy spectra during the two FD event exhibit similar variation pattern, the spectrum of Event 2 is very harder, especially at the time of deepest depression. These difference are essentially related to their associated solar wind disturbances. Event 1 is associated with a complicated shock-associated ICME structure of IP/Sheath/MC sequence with large radial extend and limited longitudinal extent (narrow and thick), probably merged from multiple shocks and transient flows. Conversely, Event 2 is accompanied by a relatively simple interplanetary disturbance of IP/Sheath/Ejecta sequence with small radial extend and wide longitudinal departure (wide and thin), possibly evolved from an over expanded CME. Such comparative study may help to clarify the occurrence mechanisms of Forbush events related to different types solar wind structures and provide valuable insight into the transient GCR modulation, especially during the unusual solar cycle 24.

  14. Vapor shielding models and the energy absorbed by divertor targets during transient events

    SciTech Connect

    Skovorodin, D. I. Arakcheev, A. S.; Pshenov, A. A.; Eksaeva, E. A.; Marenkov, E. D.; Krasheninnikov, S. I.

    2016-02-15

    The erosion of divertor targets caused by high heat fluxes during transients is a serious threat to ITER operation, as it is going to be the main factor determining the divertor lifetime. Under the influence of extreme heat fluxes, the surface temperature of plasma facing components can reach some certain threshold, leading to an onset of intense material evaporation. The latter results in formation of cold dense vapor and secondary plasma cloud. This layer effectively absorbs the energy of the incident plasma flow, turning it into its own kinetic and internal energy and radiating it. This so called vapor shielding is a phenomenon that may help mitigating the erosion during transient events. In particular, the vapor shielding results in saturation of energy (per unit surface area) accumulated by the target during single pulse of heat load at some level E{sub max}. Matching this value is one of the possible tests to verify complicated numerical codes, developed to calculate the erosion rate during abnormal events in tokamaks. The paper presents three very different models of vapor shielding, demonstrating that E{sub max} depends strongly on the heat pulse duration, thermodynamic properties, and evaporation energy of the irradiated target material. While its dependence on the other shielding details such as radiation capabilities of material and dynamics of the vapor cloud is logarithmically weak. The reason for this is a strong (exponential) dependence of the target material evaporation rate, and therefore the “strength” of vapor shield on the target surface temperature. As a result, the influence of the vapor shielding phenomena details, such as radiation transport in the vapor cloud and evaporated material dynamics, on the E{sub max} is virtually completely masked by the strong dependence of the evaporation rate on the target surface temperature. However, the very same details define the amount of evaporated particles, needed to provide an effective shielding

  15. Robust event detection scheme for complex scenes in video surveillance

    NASA Astrophysics Data System (ADS)

    Chen, Erkang; Xu, Yi; Yang, Xiaokang; Zhang, Wenjun

    2011-07-01

    Event detection for video surveillance is a difficult task due to many challenges: cluttered background, illumination variations, scale variations, occlusions among people, etc. We propose an effective and efficient event detection scheme in such complex situations. Moving shadows due to illumination are tackled with a segmentation method with shadow detection, and scale variations are taken care of using the CamShift guided particle filter tracking algorithm. For event modeling, hidden Markov models are employed. The proposed scheme also reduces the overall computational cost by combing two human detection algorithms and using tracking information to aid human detection. Experimental results on TRECVid event detection evaluation demonstrate the efficacy of the proposed scheme. It is robust, especially to moving shadows and scale variations. Employing the scheme, we achieved the best run results for two events in the TRECVid benchmarking evaluation.

  16. New Space Shuttle Observations of Transient Luminous Events During the MEIDEX

    NASA Astrophysics Data System (ADS)

    Yair, Y.; Price, C.; Israelevitch, P.; Devir, A.; Moalem, M.; Ziv, B.; Levin, Z.; Joseph, J.

    2003-12-01

    The Mediterranean Israeli Dust Experiment (MEIDEX) was conducted on-board the space shuttle Columbia during its last mission in January 2003. Nocturnal observations with a multispectral CCD video camera were targeted above thunderstorms near the Earth's limb, with the aim or recording Transient Luminous Events (TLEs) in the mesosphere. Most of our nighttime observations were conducted in the SE-Pacific (Australia and Papua-New Guinea), equatorial Africa, the southern Indian Ocean and South America. Relevant inputs and information on the active storms during a specific orbit were uplinked to the crew daily. The necessary shuttle attitude maneuvers were deduced based on the use of (almost) real-time IR satellite images and VLF lightning location data that were available on the Internet. In order to enhance the probability of success of each observation, the astronauts were instructed to visually observe lightning activity (easily discernable from the shuttle) and to direct the gimbaled camera toward these regions. A total of more than 8 hours of video obtained during the MEIDEX was saved, and it includes a considerable amount of new sprite data. Most events were captured at ranges 1600-1900 km from the shuttle, using the red filter (665nm). The results suggest the occurrence rate of sprites and elves over oceanic and continental storms may be higher than earlier estimates. Strong enhancements of the brightness of the airglow layer above lightning flashes were observed, with lateral dimensions on the order of 400-500 km. It is assumed that these may be Elves observed edge-on, though it may also be a new type of airglow enhancement. The calculated brightness of these events is in the range 2.2-8.8 MR. This phenomena seems to be widespread and is probably a manifestation of the interaction between lightning EMP and QE fields and the lower nocturnal ionosphere. A unique observation from space of the Congo basin in Africa caught a chain of events where in the span of less

  17. Very low frequency radio signatures of transient luminous events above thunderstorms

    NASA Astrophysics Data System (ADS)

    Marshall, Robert Andrew

    Lightning discharges emit intense optical and acoustic energy, in the form of lightning and thunder, respectively, but a large amount of energy is emitted as radio-frequency electromagnetic pulses (EMP). These pulses can be detected thousands of kilometers away, thanks to efficient propagation in the waveguide formed by the conducting Earth and the overlying ionosphere. In addition, intense discharges interact with the overlying ionosphere at 80-100 km altitude. The EMP-ionosphere interaction is directly observed in one manifestation as the bright transient optical emissions known as "elves", but in addition, the interaction can directly modify the free electron density in the nighttime lower ionosphere. Modifications of the ionospheric electron density can be detected via subionospheric Very Low Frequency (VLF) remote sensing. In this method, coherent signals from powerful VLF transmitters, built for submarine communication and operated by the Navy, are monitored and their amplitude and phase are tracked in time. The variations of these signais are used to sense ionospheric modifications through rapid changes in the received amplitude and/or phase when the transmitted signal propagates through an ionospheric perturbation. When these perturbations are caused by lightning, they are known as "Early VLF" perturbations, due to the negligible delay between the lightning discharge and the appearance of the VLF signal change, whereas lightning-induced electron precipitation (LEP) events have a delay of 1--2 seconds. In this work, correlations between VLF signatures and optical events are used to show that these Early VLF events may be the signature of ionospheric modification by in-cloud (IC) lightning discharges. While the more impressive cloud-to-ground (CG) lightning discharges are more commonly observed and better understood, they are outnumbered in occurrence 3:1 by IC discharges, whose effects may be relatively stronger in the overlying ionosphere. We use a 3D time

  18. Single-Event Transient Testing of the Crane Aerospace and Electronics SMHF2812D Dual DC-DC Converter

    NASA Technical Reports Server (NTRS)

    Casey, Megan

    2015-01-01

    The purpose of this testing was to characterize the Crane Aerospace & Electronics (Crane) Interpoint SMHF2812D for single-event transient (SET) susceptibility. These data shall be used for flight lot evaluation, as well as qualification by similarity of the SMHF family of converters, all of which use the same active components.

  19. 10 CFR 50.62 - Requirements for reduction of risk from anticipated transients without scram (ATWS) events for...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., other than nuclear power reactor facilities for which the certifications required under § 50.82(a)(1... transients without scram (ATWS) events for light-water-cooled nuclear power plants. 50.62 Section 50.62 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Issuance...

  20. 10 CFR 50.62 - Requirements for reduction of risk from anticipated transients without scram (ATWS) events for...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., other than nuclear power reactor facilities for which the certifications required under § 50.82(a)(1... transients without scram (ATWS) events for light-water-cooled nuclear power plants. 50.62 Section 50.62 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Issuance...

  1. 10 CFR 50.62 - Requirements for reduction of risk from anticipated transients without scram (ATWS) events for...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., other than nuclear power reactor facilities for which the certifications required under § 50.82(a)(1... transients without scram (ATWS) events for light-water-cooled nuclear power plants. 50.62 Section 50.62 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Issuance...

  2. 10 CFR 50.62 - Requirements for reduction of risk from anticipated transients without scram (ATWS) events for...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., other than nuclear power reactor facilities for which the certifications required under § 50.82(a)(1... transients without scram (ATWS) events for light-water-cooled nuclear power plants. 50.62 Section 50.62 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Issuance...

  3. 10 CFR 50.62 - Requirements for reduction of risk from anticipated transients without scram (ATWS) events for...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., other than nuclear power reactor facilities for which the certifications required under § 50.82(a)(1... transients without scram (ATWS) events for light-water-cooled nuclear power plants. 50.62 Section 50.62 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Issuance...

  4. Does inflammation predispose to recurrent vascular events after recent transient ischaemic attack and minor stroke? The North West of England transient ischaemic attack and minor stroke (NORTHSTAR) study.

    PubMed

    Selvarajah, Johann R; Smith, Craig J; Hulme, Sharon; Georgiou, Rachel; Sherrington, Charles; Staniland, John; Illingworth, Karen J; Jury, Francine; Payton, Antony; Ollier, William E; Vail, Andy; Rothwell, Nancy J; Hopkins, Stephen J; Tyrrell, Philippa J

    2011-06-01

    Inflammation is implicated in the pathogenesis and outcome of ischaemic injury. Poststroke inflammation is associated with outcome but it remains unclear whether such inflammation precedes or results from ischaemic injury. We hypothesised that inflammatory markers are associated with an increased risk of recurrent vascular events soon after transient ischaemic attack and minor stroke. This was a multicentre, prospective, nested case-control study. Plasma concentrations of C-reactive protein, interleukin-6, interleukin-1-receptor antagonist and fibrinogen, leucocyte counts, erythrocyte sedimentation rate and inflammatory gene allele frequencies were analysed in 711 patients with recent transient ischaemic attack or minor stroke. Cases were defined by the incidence of one or more recurrent vascular events during the three-month follow-up. Association of inflammatory markers with case-status was determined using conditional logistic regression. Plasma concentrations of C-reactive protein, interleukin-1-receptor antagonist and interleukin-6 were not associated with case-status. In secondary analyses, only erythrocyte sedimentation rate was significantly associated with case-status (odds ratio 1·39, 95% confidence interval 1·03-1·85; P=0·03), but this effect did not persist after adjustment for smoking and past history of transient ischaemic attack or stroke. Single nucleotide polymorphisms in four inflammatory genes (interleukin-6, fibrinogen, P-selectin and vascular cell adhesion molecule-1) were nominally associated with case-status. Circulating inflammatory markers were not associated with recurrent vascular events. Nominally significant associations between genetic markers and case-status will require replication. These data provide little evidence for an inflammatory state predisposing to stroke and other vascular events in a susceptible population. © 2011 The Authors. International Journal of Stroke © 2011 World Stroke Organization.

  5. A Semi-Automatic, Remote-Controlled Video Observation System for Transient Luminous Events

    NASA Astrophysics Data System (ADS)

    Allin, T.; Neubert, T.; Laursen, S.; Rasmussen, I. L.; Soula, S.

    2003-12-01

    In support for global ELF/VLF observations, HF measurements in France, and conjugate photometry/VLF observations in South Africa, we developed and operated a semi-automatic, remotely controlled video system for the observation of middle-atmospheric transient luminous events (TLEs). Installed at the Pic du Midi Observatory in Southern France, the system was operational during the period from July 18 to September 15, 2003. The video system, based two low-light, non-intensified CCD video cameras, was mounted on top of a motorized pan/tilt unit. The cameras and the pan/tilt unit were controlled over serial links from a local computer, and the video outputs were distributed to a pair of PCI frame grabbers in the computer. This setup allowed remote users to log in and operate the system over the internet. Event detection software provided means of recording and time-stamping single TLE video fields and thus eliminated the need for continuous human monitoring of TLE activity. The computer recorded and analyzed two parallel video streams at the full 50 Hz field rate, while uploading status images, TLE images, and system logs to a remote web server. The system detected more than 130 TLEs - mostly sprites - distributed over 9 active evenings. We have thus demonstrated the feasibility of remote agents for TLE observations, which are likely to find use in future ground-based TLE observation campaigns, or to be installed at remote sites in support for space-borne or other global TLE observation efforts.

  6. Lightning-driven electric fields measured in the lower ionosphere: Implications for transient luminous events

    NASA Astrophysics Data System (ADS)

    Thomas, Jeremy N.; Barnum, Benjamin H.; Lay, Erin; Holzworth, Robert H.; Cho, Mengu; Kelley, Michael C.

    2008-12-01

    Transient luminous events above thunderstorms such as sprites, halos, and elves require large electric fields in the lower ionosphere. Yet very few in situ measurements in this region have been successfully accomplished, since it is typically too low in altitude for rockets and satellites and too high for balloons. In this article, we present some rare examples of lightning-driven electric field changes obtained at 75-130 km altitude during a sounding rocket flight from Wallops Island, Virginia, in 1995. We summarize these electric field changes and present a few detailed case studies. Our measurements are compared directly to a 2D numerical model of lightning-driven electromagnetic fields in the middle and upper atmosphere. We find that the in situ electric field changes are smaller than predicted by the model, and the amplitudes of these fields are insufficient for elve production when extrapolated to a 100 kA peak current stroke. This disagreement could be due to lightning-induced ionospheric conductivity enhancement, or it might be evidence of flaws in the electromagnetic pulse mechanism for elves.

  7. Line-edge roughness induced single event transient variation in SOI FinFETs

    NASA Astrophysics Data System (ADS)

    Weikang, Wu; Xia, An; Xiaobo, Jiang; Yehua, Chen; Jingjing, Liu; Xing, Zhang; Ru, Huang

    2015-11-01

    The impact of process induced variation on the response of SOI FinFET to heavy ion irradiation is studied through 3-D TCAD simulation for the first time. When FinFET biased at OFF state configuration (Vgs = 0, Vds = Vdd) is struck by a heavy ion, the drain collects ionizing charges under the electric field and a current pulse (single event transient, SET) is consequently formed. The results reveal that with the presence of line-edge roughness (LER), which is one of the major variation sources in nano-scale FinFETs, the device-to-device variation in terms of SET is observed. In this study, three types of LER are considered: type A has symmetric fin edges, type B has irrelevant fin edges and type C has parallel fin edges. The results show that type A devices have the largest SET variation while type C devices have the smallest variation. Further, the impact of the two main LER parameters, correlation length and root mean square amplitude, on SET variation is discussed as well. The results indicate that variation may be a concern in radiation effects with the down scaling of feature size.

  8. Plasma radiation distribution and radiation loads onto the vessel during transient events in JET

    NASA Astrophysics Data System (ADS)

    Huber, A.; Pitts, R. A.; Loarte, A.; Philipps, V.; Andrew, P.; Brezinsek, S.; Coad, J. P.; Eich, T.; Fuchs, J. C.; Fundamenski, W.; Jachmich, S.; Matthews, G. F.; McCormick, K.; Mertens, Ph.; Rapp, J.; Sergienko, G.; Stamp, M. F.; JET EFDA contributors

    2009-06-01

    The JET bolometer camera system allows greatly improved tomographic reconstruction of the radiation pattern on a timescale of the order of the typical duration of a Type I ELM period (≈0.1-0.4 ms). The ELM-induced radiation is always higher at the inner than at the outer divertor with an approximately linear increase of the asymmetry up to a total Δ WELM of about 0.6 MJ and a decrease for higher Δ WELM. Large Type I ELMs with energy losses above 0.65-0.7 MJ show enhanced radiation losses, which are associated with the ablation of thick co-deposited layers in the inner divertor. During the 'compound' phase, plasma contamination can increase but does not usually lead to radiative collapse of the plasma. It is found that the radiation distribution during the transient events is poloidally asymmetric with a maximum of the observed 'radiation peaking factor' for the disruptive current quench and for MARFEs of about 4.5, and less than 5 during VDEs.

  9. Repression of early lateral root initiation events by transient water deficit in barley and maize

    PubMed Central

    Babé, Aurélie; Lavigne, Tristan; Séverin, Jean-Philippe; Nagel, Kerstin A.; Walter, Achim; Chaumont, François; Batoko, Henri; Beeckman, Tom; Draye, Xavier

    2012-01-01

    The formation of lateral roots (LRs) is a key driver of root system architecture and developmental plasticity. The first stage of LR formation, which leads to the acquisition of founder cell identity in the pericycle, is the primary determinant of root branching patterns. The fact that initiation events occur asynchronously in a very small number of cells inside the parent root has been a major difficulty in the study of the molecular regulation of branching patterns. Inducible systems that trigger synchronous lateral formation at predictable sites have proven extremely valuable in Arabidopsis to decipher the first steps of LR formation. Here, we present a LR repression system for cereals that relies on a transient water-deficit treatment, which blocks LR initiation before the first formative divisions. Using a time-lapse approach, we analysed the dynamics of this repression along growing roots and were able to show that it targets a very narrow developmental window of the initiation process. Interestingly, the repression can be exploited to obtain negative control root samples where LR initiation is absent. This system could be instrumental in the analysis of the molecular basis of drought-responsive as well as intrinsic pathways of LR formation in cereals. PMID:22527396

  10. Moving Object and Transient Event Search System (MOTESS): An Economical Optical Survey Prototype

    NASA Astrophysics Data System (ADS)

    Tucker, R. A.

    2002-05-01

    The Moving Object and Transient Event Search System (MOTESS) prototype has been operating since April 2001. This instrument has demonstrated that it is possible to economically and reliably survey equatorial regions of the sky at high temporal frequency and produce a stream of high quality image data. As presently configured, MOTESS consists of three, 35-cm aperture, f/5 Newtonian telescopes with 10242 px, thinned CCD cameras. Operating in scan mode, each instrument can cover 12 sq degrees of sky per hour to approximately magnitude 20 (unfiltered). The prototype system is presently located in Tucson, Arizona at the Goodricke-Pigott Observatory. The original motivation for developing this system was the detection and astrometry of earth-approaching asteroids. More recently, the system has been recognized as a viable means for fulfilling specific science goals of the Global Network of Astronomical Telescopes (GNAT) and an effort is underway to develop a geographically distributed network of such telescopes. In this paper we present a description of some of the novel design aspects intended to maximize independent, automated operation of the system.

  11. Auditory P300 event related potentials in acute and transient psychosis-Comparison with schizophrenia.

    PubMed

    Sahoo, Swapnajeet; Malhotra, Savita; Basu, Debasish; Modi, Manish

    2016-10-01

    Limited biological research data are available on acute and transient psychotic disorder (ATPD) vis-à-vis schizophrenia. P300 event related potentials (ERP) have been extensively studied as an important neurophysiological parameter in schizophrenia. However, no P300 ERP studies comparing the two disorders are available. We compared auditory P300 ERP in patients remitted from ATPD with schizophrenia in remission and biologically unrelated healthy controls. In this case-control study design, 25 subjects remitted from ATPD were age-/gender-matched with healthy controls and patients with schizophrenia in remission. Clinical assessment and auditory P300 ERP (amplitude and latencies at central and parietal sites, reaction time) were recorded. The ERP parameters were compared across the three groups. All three groups showed significant differences in P300 amplitudes and latencies at central and parietal sites. Schizophrenia group differed significantly (p<0.001) from the ATPD group in all the P300 parameters. The ATPD group was found to have lower Pz latency (p<0.05) and lower mean reaction time (p<0.001) as compared to healthy controls. The results suggest that P300 could easily distinguish between ATPD and schizophrenia in remission, thus neurophysiologically differentiating the two disorders. Lower P300 latency and reaction time, which indicate hyper-arousability, distinguished ATPD from normal controls, with implications for a better understanding of ATPD. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Transient Flux Transport Events in the Near-tail and at Lunar Orbit

    NASA Astrophysics Data System (ADS)

    Runov, A.

    2016-12-01

    Numerous observations have shown that the magnetic flux transport in the near-Earth magnetotail is impulsive with a characteristic time scale varying between a few tens to a few hundreds of seconds (i.e., a few to tens of proton gyroperiods). It has been also shown that the spatial scale of the flux transport pulses is 1 to 3 earth radii (i.e., a few tens of proton inertial lengths). It is also well established that the transient flux transport events are dominantly observed in the premidnight magnetotail sector. Recent observations by ARTEMIS duo have revealed that tailward flux transport on Lunar orbit is, typically, impulsive with spatio-temporal scales similar to those observed in the near tail. The probability to observe tailward flux transport on Lunar orbit is higher in the premidnight sector. A concept of impulsive (time-dependent) magnetic reconnection may explain the short-time flux transport pulses, observed earthward and tailward of the reconnection site. It is unknown, however, what determines the characteristic time scale and spatial localization of the flux transport pulses. A role of Rayleigh-Taylor-type and drift instabilities in structuring and localization of the flux bursts is another open question.

  13. Transient protection of strained alkynes from click reaction via complexation with copper.

    PubMed

    Yoshida, Suguru; Hatakeyama, Yasutomo; Johmoto, Kohei; Uekusa, Hidehiro; Hosoya, Takamitsu

    2014-10-01

    A transient protection method of cyclooctynes from a click reaction with an azide through 1:1 complexation with a cationic copper(I) salt is reported. The application of the method to a cyclooctyne bearing a terminal alkyne enabled the selective copper-catalyzed click conjugation with an azide at the terminal alkyne moiety, which made cyclooctyne derivatives readily accessible.

  14. Computer program simplifies transient and steady-state temperature prediction for complex body shapes

    NASA Technical Reports Server (NTRS)

    Giebler, K. N.

    1966-01-01

    Computer program evaluates heat transfer modes and calculates either the transient or steady-state temperature distributions throughout an object of complex shape when heat sources are applied to specified points on the object. It uses an electrothermal model to simulate the conductance, heat capacity, and temperature potential of the object.

  15. Extreme events and natural hazards: The complexity perspective

    NASA Astrophysics Data System (ADS)

    Schultz, Colin

    2012-10-01

    Advanced societies have become quite proficient at defending against moderate-size earthquakes, hurricanes, floods, or other natural assaults. What still pose a significant threat, however, are the unknowns, the extremes, the natural phenomena encompassed by the upper tail of the probability distribution. Alongside the large or powerful events, truly extreme natural disasters are those that tie different systems together: an earthquake that causes a tsunami, which leads to flooding, which takes down a nuclear reactor. In the geophysical monograph Extreme Events and Natural Hazards: The Complexity Perspective, editors A. Surjalal Sharma, Armin Bunde, Vijay P. Dimro, and Daniel N. Baker present a lens through which such multidisciplinary phenomena can be understood. In this interview, Eos talks to Sharma about complexity science, predicting extreme events and natural hazards, and the push for "big data."

  16. Transient thrust events recorded in the Aare Massif, Bernese Alps (Grimsel Test Site, Switzerland)

    NASA Astrophysics Data System (ADS)

    Hartvich, F.; Stemberk, J.

    2016-12-01

    The Grimsel Test Site (GTS) is located at an altitude of 1730 m a.s.l. in the granitic formations of the Aare Massif 300 - 500 m under the surface. In November 2012, documented faults within the GTS were instrumented for 3-D monitoring of fault slips in the scope of the LArge Scale MOnitoring project (LASMO). In total 7 devices were installed across faults crossing a 350 m long section of the GTS. The instrumented faults have various strike: W-E, SW-NE, WNW-ESE and WSW-ENE. The faults are instrumented with optical-mechanical extensometers TM71 which allow to measure 3D micro-displacements as well as rotations on the basis of the moiré effect of optical interference. The devices installed in GTS reach the accuracy better than 0.007 mm and the angular deviation between two blocks separated by a discontinuity - i.e. their relative rotation - can be measured with a resolution better than 0.00016 rad. Regular monitoring has started on Dec. 5,2012 and the reading is performed regularly once per day. The first results of 3-D fault displacement monitoring show transient slips recorded during 2 short periods along all monitored faults, alternating with long periods of tectonic quiescence without any fault activity. The measured directions of fault slips enable us to estimate two approximately N - S oriented compression events, causing northwards thrust movements. First period lasted from Dec. 27, 2012 to Feb. 13, 2013. However, major phase of the displacement occurred between Jan. 26 and 29, 2013. Recorded fault slips represent northwards oriented thrusts and strike-slips. A value of individual slips ranges from 0.004 to 0.04 mm. Moreover, the strike-slip movements were recorded during days when two local micro-earthquakes were observed close to GTS: on Jan. 29, 2013 (M = 1.29) and on Feb. 13, 2013 (M = 1.15). The second period of activity lasted from Sept. 7, 2013 to Oct. 28, 2013, and occurred after more than 7 months of no recorded fault slips. The main phase of the

  17. A pilot ASKAP survey of radio transient events in the region around the intermittent pulsar PSR J1107-5907

    NASA Astrophysics Data System (ADS)

    Hobbs, G.; Heywood, I.; Bell, M. E.; Kerr, M.; Rowlinson, A.; Johnston, S.; Shannon, R. M.; Voronkov, M. A.; Ward, C.; Banyer, J.; Hancock, P. J.; Murphy, Tara; Allison, J. R.; Amy, S. W.; Ball, L.; Bannister, K.; Bock, D. C.-J.; Brodrick, D.; Brothers, M.; Brown, A. J.; Bunton, J. D.; Chapman, J.; Chippendale, A. P.; Chung, Y.; DeBoer, D.; Diamond, P.; Edwards, P. G.; Ekers, R.; Ferris, R. H.; Forsyth, R.; Gough, R.; Grancea, A.; Gupta, N.; Harvey-Smith, L.; Hay, S.; Hayman, D. B.; Hotan, A. W.; Hoyle, S.; Humphreys, B.; Indermuehle, B.; Jacka, C. E.; Jackson, C. A.; Jackson, S.; Jeganathan, K.; Joseph, J.; Kendall, R.; Kiraly, D.; Koribalski, B.; Leach, M.; Lenc, E.; MacLeod, A.; Mader, S.; Marquarding, M.; Marvil, J.; McClure-Griffiths, N.; McConnell, D.; Mirtschin, P.; Neuhold, S.; Ng, A.; Norris, R. P.; O'Sullivan, J.; Pearce, S.; Phillips, C. J.; Popping, A.; Qiao, R. Y.; Reynolds, J. E.; Roberts, P.; Sault, R. J.; Schinckel, A. E. T.; Serra, P.; Shaw, R.; Shimwell, T. W.; Storey, M.; Sweetnam, A. W.; Tzioumis, A.; Westmeier, T.; Whiting, M.; Wilson, C. D.

    2016-03-01

    We use observations from the Boolardy Engineering Test Array (BETA) of the Australian Square Kilometre Array Pathfinder (ASKAP) telescope to search for transient radio sources in the field around the intermittent pulsar PSR J1107-5907. The pulsar is thought to switch between an `off' state in which no emission is detectable, a weak state and a strong state. We ran three independent transient detection pipelines on two-minute snapshot images from a 13 h BETA observation in order to (1) study the emission from the pulsar, (2) search for other transient emission from elsewhere in the image and (3) to compare the results from the different transient detection pipelines. The pulsar was easily detected as a transient source and, over the course of the observations, it switched into the strong state three times giving a typical time-scale between the strong emission states of 3.7 h. After the first switch it remained in the strong state for almost 40 min. The other strong states lasted less than 4 min. The second state change was confirmed using observations with the Parkes radio telescope. No other transient events were found and we place constraints on the surface density of such events on these time-scales. The high sensitivity Parkes observations enabled us to detect individual bright pulses during the weak state and to study the strong state over a wide observing band. We conclude by showing that future transient surveys with ASKAP will have the potential to probe the intermittent pulsar population.

  18. Complex events in a fault model with interacting asperities

    NASA Astrophysics Data System (ADS)

    Dragoni, Michele; Tallarico, Andrea

    2016-08-01

    The dynamics of a fault with heterogeneous friction is studied by employing a discrete fault model with two asperities of different strengths. The average values of stress, friction and slip on each asperity are considered and the state of the fault is described by the slip deficits of the asperities as functions of time. The fault has three different slipping modes, corresponding to the asperities slipping one at a time or simultaneously. Any seismic event produced by the fault is a sequence of n slipping modes. According to initial conditions, seismic events can be different sequences of slipping modes, implying different moment rates and seismic moments. Each event can be represented geometrically in the state space by an orbit that is the union of n damped Lissajous curves. We focus our interest on events that are sequences of two or more slipping modes: they show a complex stress interchange between the asperities and a complex temporal pattern of slip rate. The initial stress distribution producing these events is not uniform on the fault. We calculate the stress drop, the moment rate and the frequency spectrum of the events, showing how these quantities depend on initial conditions. These events have the greatest seismic moments that can be produced by fault slip. As an example, we model the moment rate of the 1992 Landers, California, earthquake that can be described as the consecutive failure of two asperities, one of which has a double strength than the other, and evaluate the evolution of stress distribution on the fault during the event.

  19. Alkylation of terminal alkynes with transient σ-alkylpalladium(II) complexes: a carboalkynylation route to alkyl-substituted alkynes.

    PubMed

    Zhou, Ming-Bo; Huang, Xiao-Cheng; Liu, Yan-Yun; Song, Ren-Jie; Li, Jin-Heng

    2014-02-10

    A mild and general alkylation of terminal alkynes with transient σ-alkylpalladium(II) complexes for assembling alkyl-substituted alkynes is described. This method represents a new way to the use of transient σ-alkylpalladium(II) complexes in organic synthesis through 1,2-carboalkynylation of alkenes.

  20. An infrastructure for accurate characterization of single-event transients in digital circuits☆

    PubMed Central

    Savulimedu Veeravalli, Varadan; Polzer, Thomas; Schmid, Ulrich; Steininger, Andreas; Hofbauer, Michael; Schweiger, Kurt; Dietrich, Horst; Schneider-Hornstein, Kerstin; Zimmermann, Horst; Voss, Kay-Obbe; Merk, Bruno; Hajek, Michael

    2013-01-01

    We present the architecture and a detailed pre-fabrication analysis of a digital measurement ASIC facilitating long-term irradiation experiments of basic asynchronous circuits, which also demonstrates the suitability of the general approach for obtaining accurate radiation failure models developed in our FATAL project. Our ASIC design combines radiation targets like Muller C-elements and elastic pipelines as well as standard combinational gates and flip-flops with an elaborate on-chip measurement infrastructure. Major architectural challenges result from the fact that the latter must operate reliably under the same radiation conditions the target circuits are exposed to, without wasting precious die area for a rad-hard design. A measurement architecture based on multiple non-rad-hard counters is used, which we show to be resilient against double faults, as well as many triple and even higher-multiplicity faults. The design evaluation is done by means of comprehensive fault injection experiments, which are based on detailed Spice models of the target circuits in conjunction with a standard double-exponential current injection model for single-event transients (SET). To be as accurate as possible, the parameters of this current model have been aligned with results obtained from 3D device simulation models, which have in turn been validated and calibrated using micro-beam radiation experiments at the GSI in Darmstadt, Germany. For the latter, target circuits instrumented with high-speed sense amplifiers have been used for analog SET recording. Together with a probabilistic analysis of the sustainable particle flow rates, based on a detailed area analysis and experimental cross-section data, we can conclude that the proposed architecture will indeed sustain significant target hit rates, without exceeding the resilience bound of the measurement infrastructure. PMID:24748694

  1. An infrastructure for accurate characterization of single-event transients in digital circuits.

    PubMed

    Savulimedu Veeravalli, Varadan; Polzer, Thomas; Schmid, Ulrich; Steininger, Andreas; Hofbauer, Michael; Schweiger, Kurt; Dietrich, Horst; Schneider-Hornstein, Kerstin; Zimmermann, Horst; Voss, Kay-Obbe; Merk, Bruno; Hajek, Michael

    2013-11-01

    We present the architecture and a detailed pre-fabrication analysis of a digital measurement ASIC facilitating long-term irradiation experiments of basic asynchronous circuits, which also demonstrates the suitability of the general approach for obtaining accurate radiation failure models developed in our FATAL project. Our ASIC design combines radiation targets like Muller C-elements and elastic pipelines as well as standard combinational gates and flip-flops with an elaborate on-chip measurement infrastructure. Major architectural challenges result from the fact that the latter must operate reliably under the same radiation conditions the target circuits are exposed to, without wasting precious die area for a rad-hard design. A measurement architecture based on multiple non-rad-hard counters is used, which we show to be resilient against double faults, as well as many triple and even higher-multiplicity faults. The design evaluation is done by means of comprehensive fault injection experiments, which are based on detailed Spice models of the target circuits in conjunction with a standard double-exponential current injection model for single-event transients (SET). To be as accurate as possible, the parameters of this current model have been aligned with results obtained from 3D device simulation models, which have in turn been validated and calibrated using micro-beam radiation experiments at the GSI in Darmstadt, Germany. For the latter, target circuits instrumented with high-speed sense amplifiers have been used for analog SET recording. Together with a probabilistic analysis of the sustainable particle flow rates, based on a detailed area analysis and experimental cross-section data, we can conclude that the proposed architecture will indeed sustain significant target hit rates, without exceeding the resilience bound of the measurement infrastructure.

  2. Ultrafast transient absorption studies of ruthenium and rhenium dipyridophenazine complexes bound to DNA and polynucleotides

    NASA Astrophysics Data System (ADS)

    Creely, Caitriona M.; Kelly, John M.; Feeney, M. M.; Hudson, S.; Penedo, J. C.; Blau, Werner J.; Elias, B.; Kirsch-De Mesmaeker, Andree; Matousek, P.; Towrie, M.; Parker, A. W.; Dyer, J. S.; George, Mikhael W.; Coates, C. G.; McGarvey, John J.

    2003-03-01

    We report on ultrafast pump and probe studies of biological systems, in the form of polynucleotide and calf thymus DNA complexes. Molecules for study are bound to the polynucleotides and probed in the visible region to observe changes in the absorption over time. Various dipyridophenazine metal complexes are studied alone and complexed with DNA or synthetic polynucleotides to investigate changes occurring in their excited states upon interacting with nucleobases. Transient absorption measurements are performed pumping at 400nm and probing from 450-700nm with pulse duration of 400fs.

  3. Secure complex event processing in a heterogeneous and dynamic network

    NASA Astrophysics Data System (ADS)

    Buddhika, Thilina; Ray, Indrakshi; Linderman, Mark; Jayasumana, Anura

    2014-06-01

    Battlefield monitoring involves collecting streaming data from different sources, transmitting the data over a heterogeneous network, and processing queries in real-time in order to respond to events in a timely manner. Nodes in these networks differ with respect to their trustworthiness, processing, storage, and communication capabilities. Links in the network differ with respect to their communication bandwidth. The topology of the network itself is subject to change, as the nodes and links may become unavailable. Continuous queries executed in such environments must also meet some quality of service (QoS) requirements, such as, response time and throughput. Data streams generated from the various nodes in the network belong to different security levels; consequently, these must be processed in a secure manner without causing unauthorized leakage or modification. Towards this end, we demonstrate how an existing complex event processing system can be extended to execute queries and events in a secure manner in such a dynamic and heterogeneous environment.

  4. Single Event Transients Induced by Picosecond Pulsed X-Ray Absorption in III-V Heterojunction Transistors

    SciTech Connect

    Cardoza, David M; LaLumondiere, Stephen D; Tockstein, Michael A; Witczak, Steven C; Sin, Yongkun; Foran, Brendan J; Lotshaw, William T; Moss, Steven C

    2013-01-17

    We perform measurements which show that focused, picosecond pulses of x-rays can be used to generate single event transients (SET) in a GaAs heterostructure field effect transistor (HFET) and a GaN high electron mobility transistor. X-ray pulses with photon energies of 8, 10 and 12 keV from the Advanced Photon Source at Argonne National Laboratory were used to excite transients. SETs are observed when x-ray pulses are incident upon metal layers above sensitive areas on the transistors. We use focused ion beam (FIB) cross-sectioning and scanning transmission electron microscopy energy dispersive x-ray spectroscopy (STEM-EDXS) to determine the compositional structure of the devices. We present a first order analysis of energy deposition in the devices and correlate it to the transient response to make preliminary interpretations of the results. We compare the x-ray transients from the GaAs HFET with transients generated by 750 nm and 870 nm femtosecond laser pulses. We also present results on the total dose susceptibility of the GaN HEMTs.

  5. Simulating an Extreme Wind Event in a Topographically Complex Region

    NASA Astrophysics Data System (ADS)

    Lennard, Christopher

    2014-07-01

    Complex topography modifies local weather characteristics such as air temperature, rainfall and airflow within a larger regional extent. The Cape Peninsula around Cape Town, South Africa, is a complex topographical feature responsible for the modification of rainfall and wind fields largely downstream of the Peninsula. During the passage of a cold front on 2 October 2002, an extreme wind event associated with tornado-like damage occurred in the suburb of Manenberg, however synoptic conditions did not indicate convective activity typically associated with a tornado. A numerical regional climate model was operated at very high horizontal resolution (500 m) to investigate the dynamics of the event. The model simulated an interaction between the topography of the peninsula and an airflow direction change associated with the passage of the cold front. A small region of cyclonic circulation was simulated over Manenberg that was embedded in an area of negative vorticity and a leeward gravity wave. The feature lasted 14 min and moved in a north to south direction. Vertically, it was not evident above 220 m. The model assessment describes this event as a shallow but intense cyclonic vortex generated in the lee of the peninsula through an interaction between the peninsula and a change in wind direction as the cold front made landfall. The model did not simulate wind speeds associated with the observed damage suggesting that the horizontal grid resolution ought to be at the scale of the event to more completely understand such microscale airflow phenomena.

  6. Applications of IR Thermography in Capturing Thermal Transients and Other High-Speed Thermal Events

    SciTech Connect

    Dinwiddie, R.B.; Graham, S.; Wang, H.

    1999-06-07

    The high-speed, snap-shot mode, and the external triggering capability of an IR camera allows thermal transients to be captured. These advanced features were used to capture thermal transients during electrical breakdown of ZnO varistors and to freeze the rotation of an automobile disk brake in order to study thermoplastic instability in the braking system. The IR camera also showed the thermoplastic effect during cyclic fatigue testing of a glass matrix composite.

  7. How does rapidly changing discharge during storm events affect transient storage and channel water balance in a headwater mountain stream?

    Treesearch

    Adam S. Ward; Michael N. Gooseff; Thomas J. Voltz; Michael Fitzgerald; Kamini Singha; Jay P. Zarnetske

    2013-01-01

    Measurements of transient storage in coupled surface-water and groundwater systems are widely made during base flow periods and rarely made during storm flow periods. We completed 24 sets of slug injections in three contiguous study reaches during a 1.25 year return interval storm event (discharge ranging from 21.5 to 434 L s1 ) in a net gaining headwater stream within...

  8. Complex transient dynamics of hidden attractors in a simple 4D system

    NASA Astrophysics Data System (ADS)

    Dang, Xiao-Yu; Li, Chun-Biao; Bao, Bo-Cheng; Wu, Hua-Gan

    2015-05-01

    A simple four-dimensional system with only one control parameter is proposed in this paper. The novel system has a line or no equilibrium for the global control parameter and exhibits complex transient transition behaviors of hyperchaotic attractors, periodic orbits, and unstable sinks. Especially, for the nonzero-valued control parameter, there exists no equilibrium in the proposed system, leading to the formation of various hidden attractors with complex transient dynamics. The research results indicate that the dynamics of the system shows weak chaotic robustness and depends greatly on the initial states. Project supported by the National Natural Science Foundation of China (Grant No. 51277017), the Natural Science Foundation of Jiangsu Province, China (Grant No. BK2012583), and the Fundamental Research Funds for the Central Universities of China (Grant No. NS2014038).

  9. Ground-based complex for detection and investigation of fast optical transients in wide field

    NASA Astrophysics Data System (ADS)

    Molinari, Emilio; Beskin, Grigory; Bondar, Sergey; Karpov, Sergey; Plokhotnichenko, Vladimir; de-Bur, Vjacheslav; Greco, Guiseppe; Bartolini, Corrado; Guarnieri, Adriano; Piccioni, Adalberto

    2008-07-01

    To study short stochastic optical flares of different objects (GRBs, SNs, etc) of unknown localizations as well as NEOs it is necessary to monitor large regions of sky with high time resolution. We developed a system which consists of wide-field camera (FOW is 400-600 sq.deg.) using TV-CCD with time resolution of 0.13 s to record and classify optical transients, and a fast robotic telescope aimed to perform their spectroscopic and photometric investigation just after detection. Such two telescope complex TORTOREM combining wide-field camera TORTORA and robotic telescope REM operated from May 2006 at La Silla ESO observatory. Some results of its operation, including first fast time resolution study of optical transient accompanying GRB and discovery of its fine time structure, are presented. Prospects for improving the complex efficiency are given.

  10. LEONA: Transient Luminous Event and Thunderstorm High Energy Emission Collaborative Network in Latin America

    NASA Astrophysics Data System (ADS)

    Sao Sabbas, F. T.

    2012-12-01

    This project has the goal of establishing the Collaborative Network LEONA, to study the electrodynamical coupling of the atmospheric layers signaled by Transient Luminous Events - TLEs and high energy emissions from thunderstorms. We will develop and install a remotely controlled network of cameras to perform TLE observations in different locations in South America and one neutron detector in southern Brazil. The camera network will allow building a continuous data set of the phenomena studied in this continent. The first two trial units of the camera network are already installed, in Brazil and Peru, and two more will be installed until December 2012, in Argentina and Brazil. We expect to determine the TLE geographic distribution, occurrence rate, morphology, and possible coupling with other geophysical phenomena in South America, such as the South Atlantic Magnetic Anomaly - SAMA. We also expect to study thunderstorm neutron emissions in a region of intense electrical activity, measuring neutron fluxes with high time resolution simultaneously with TLEs and lightning for the first time in South America. Using an intensified high-speed camera for TLE observation during 2 campaigns we expect to be able to determine the duration and spatial- temporal development of the TLEs observed, to study the structure and initiation of sprites and to measure the velocity of development of sprite structures and the sprite delay. The camera was acquired via the FAPESP project DEELUMINOS (2005-2010), which also nucleated our research group Atmospheric Electrodynamical Coupling - ACATMOS. LEONA will nucleate this research in other institutions in Brazil and other countries in South America, providing continuity for this important research in our region. The camera network will be an unique tool to perform consistent long term TLE observation, and in fact is the only way to accumulate a data set for a climatological study of South America, since satellite instrumentation turns off in

  11. Modeling the Potential Volume of Gas Hydrates Over Time and During Transient Climate Events

    NASA Astrophysics Data System (ADS)

    Dickens, G. R.; Dickens, G. R.

    2001-12-01

    Gas hydrates in marine sediment probably serve as a large bacterially mediated capacitor in the global carbon cycle, storing and releasing CH4 with changes in external forcing. Although germinal, models of the global carbon cycle that incorporate gas hydrates require characterization of the available pore space -- the potential volume -- over time, especially during transient climate events. Potentially, gas hydrates can occur between the seafloor and a locus of subbottom depths where geothermal gradients intersect gas-gas hydrate-pore water equilibrium curves. Perpendicular to a given continental margin, the lens shaped area between these two bounding surfaces (Asl) varies according to seven basic parameters: gas composition, water activity (aw), bottom water temperature (Tb), geothermal gradient (G), slope depth (zslb), slope gradient (Z) and sea level relative to the shelf break (zo). Assuming pure CH4 gas, ~35 km2 of sediment can host gas hydrate across an average continental margin at a Pleistocene lowstand (aw = 0.981, Tb = 0° C, G = 0.05° C/m; zslb = 4000 m; Z = 0.04; zo = 0). However, this potential area would decrease with smaller aw, higher Tb, greater G, shallower zslb, steeper Z and lower zo, and increase with opposite external conditions. Of the basic parameters, temperature (Tb and G) and bathymetry (zslb and Z) can particularly influence the distribution of gas hydrate on continental slopes. A hydrothermal gradient (i.e., surface temperatures > Tb) will also decrease Asl, although minimally, especially if Tb exceeds 5° . The sum of parallel cross-sectional areas along a margin combined with porosity (φ ) gives the potential volume of gas hydrate (V). Assuming ~200,000 km of continental margin with φ of 0.50, ~3.5 x 106 km3 of pore space can contain gas hydrates at present-day, a volume that compares favorably with previous estimates (1.2 to 6.4 x 106 km3) although underlying approaches differ fundamentally. Since the Triassic, VGlob probably has

  12. Imaging Parameters and Recurrent Cerebrovascular Events in Patients With Minor Stroke or Transient Ischemic Attack

    PubMed Central

    Yaghi, Shadi; Rostanski, Sara K.; Boehme, Amelia K.; Martin-Schild, Sheryl; Samai, Alyana; Silver, Brian; Blum, Christina A.; Jayaraman, Mahesh V.; Siket, Matthew S.; Khan, Muhib; Furie, Karen L.; Elkind, Mitchell S. V.; Marshall, Randolph S.; Willey, Joshua Z.

    2016-01-01

    IMPORTANCE Neurological worsening and recurrent stroke contribute substantially to morbidity associated with transient ischemic attacks and strokes (TIA-S). OBJECTIVE To determine predictors of early recurrent cerebrovascular events (RCVEs) among patients with TIA-S and National Institutes of Health Stroke Scale scores of 0 to 3. DESIGN, SETTING, AND PARTICIPANTS A retrospective cohort study was conducted at 2 tertiary care centers (Columbia University Medical Center, New York, New York, and Tulane University Medical Center, New Orleans, Louisiana) between January 1, 2010, and December 31, 2014. All patients with neurologist-diagnosed TIA-S with a National Institutes of Health Stroke Scale score of 0 to 3 who presented to the emergency department were included. MAIN OUTCOMES AND MEASURES The primary outcome (adjudicated by 3 vascular neurologists) was RCVE: neurological deterioration in the absence of a medical explanation or recurrent TIA-S during hospitalization. RESULTS Of the 1258 total patients, 1187 had no RCVEs and 71 had RCVEs; of this group, 750 patients (63.2%) and 39 patients (54.9%), respectively, were aged 60 years or older. There were 505 patients with TIA-S at Columbia University; 31 (6.1%) had RCVEs (15 patients had neurological deterioration only, 11 had recurrent TIA-S only, and 5 had both). The validation cohort at Tulane University consisted of 753 patients; 40 (5.3%) had RCVEs (24 patients had neurological deterioration only and 16 had both). Predictors of RCVE in multivariate models in both cohorts were infarct on neuroimaging (computed tomographic scan or diffusion-weighted imaging sequences on magnetic resonance imaging) (Columbia University: not applicable and Tulane University: odds ratio, 1.75; 95% CI, 0.82–3.74; P = .15) and large-vessel disease etiology (Columbia University: odds ratio, 6.69; 95% CI, 3.10–14.50 and Tulane University: odds ratio, 8.13; 95% CI, 3.86–17.12; P < .001). There was an increase in the percentage of

  13. Transient versus Static Electron Spin Relaxation in Mn(2+) Complexes Relevant as MRI Contrast Agents.

    PubMed

    Platas-Iglesias, Carlos; Esteban-Gómez, David; Helm, Lothar; Regueiro-Figueroa, Martín

    2016-08-18

    The zero-field splitting (ZFS) parameters of the [Mn(EDTA)(H2O)](2-)·2H2O and [Mn(MeNO2A)(H2O)]·2H2O systems were estimated by using DFT and ab initio CASSCF/NEVPT2 calculations (EDTA = 2,2',2″,2‴-(ethane-1,2-diylbis(azanetriyl))tetraacetate; MeNO2A = 2,2'-(7-methyl-1,4,7-triazonane-1,4-diyl)diacetate). Subsequent molecular dynamics calculations performed within the atom-centered density matrix propagation (ADMP) approach provided access to the transient and static ZFS parameters, as well as to the correlation time of the transient ZFS. The calculated ZFS parameters present a reasonable agreement with the experimental values obtained from the analysis of (1)H relaxation data. The correlation times calculated for the two systems investigated turned out to be very short (τc ∼ 0.02-0.05 ps), which shows that the transient ZFS is modulated by molecular vibrations. On the contrary, the static ZFS is modulated by the rotation of the complexes in solution, which for the small complexes investigated here is characterized by rotational correlation times of τR ∼ 35-60 ps. As a result, electron spin relaxation in small Mn(2+) complexes is dominated by the static ZFS.

  14. Modeling of Single Event Transients With Dual Double-Exponential Current Sources: Implications for Logic Cell Characterization

    NASA Astrophysics Data System (ADS)

    Black, Dolores A.; Robinson, William H.; Wilcox, Ian Z.; Limbrick, Daniel B.; Black, Jeffrey D.

    2015-08-01

    Single event effects (SEE) are a reliability concern for modern microelectronics. Bit corruptions can be caused by single event upsets (SEUs) in the storage cells or by sampling single event transients (SETs) from a logic path. An accurate prediction of soft error susceptibility from SETs requires good models to convert collected charge into compact descriptions of the current injection process. This paper describes a simple, yet effective, method to model the current waveform resulting from a charge collection event for SET circuit simulations. The model uses two double-exponential current sources in parallel, and the results illustrate why a conventional model based on one double-exponential source can be incomplete. A small set of logic cells with varying input conditions, drive strength, and output loading are simulated to extract the parameters for the dual double-exponential current sources. The parameters are based upon both the node capacitance and the restoring current (i.e., drive strength) of the logic cell.

  15. Consolidation of Complex Events via Reinstatement in Posterior Cingulate Cortex

    PubMed Central

    Keidel, James L.; Ing, Leslie P.; Horner, Aidan J.

    2015-01-01

    It is well-established that active rehearsal increases the efficacy of memory consolidation. It is also known that complex events are interpreted with reference to prior knowledge. However, comparatively little attention has been given to the neural underpinnings of these effects. In healthy adults humans, we investigated the impact of effortful, active rehearsal on memory for events by showing people several short video clips and then asking them to recall these clips, either aloud (Experiment 1) or silently while in an MRI scanner (Experiment 2). In both experiments, actively rehearsed clips were remembered in far greater detail than unrehearsed clips when tested a week later. In Experiment 1, highly similar descriptions of events were produced across retrieval trials, suggesting a degree of semanticization of the memories had taken place. In Experiment 2, spatial patterns of BOLD signal in medial temporal and posterior midline regions were correlated when encoding and rehearsing the same video. Moreover, the strength of this correlation in the posterior cingulate predicted the amount of information subsequently recalled. This is likely to reflect a strengthening of the representation of the video's content. We argue that these representations combine both new episodic information and stored semantic knowledge (or “schemas”). We therefore suggest that posterior midline structures aid consolidation by reinstating and strengthening the associations between episodic details and more generic schematic information. This leads to the creation of coherent memory representations of lifelike, complex events that are resistant to forgetting, but somewhat inflexible and semantic-like in nature. SIGNIFICANCE STATEMENT Memories are strengthened via consolidation. We investigated memory for lifelike events using video clips and showed that rehearsing their content dramatically boosts memory consolidation. Using MRI scanning, we measured patterns of brain activity while

  16. Complex transient dynamics of stage-structured populations in response to environmental changes.

    PubMed

    Massie, Thomas M; Ryabov, Alexei; Blasius, Bernd; Weithoff, Guntram; Gaedke, Ursula

    2013-07-01

    Stage structures of populations can have a profound influence on their dynamics. However, not much is known about the transient dynamics that follow a disturbance in such systems. Here we combined chemostat experiments with dynamical modeling to study the response of the phytoplankton species Chlorella vulgaris to press perturbations. From an initially stable steady state, we altered either the concentration or dilution rate of a growth-limiting resource. This disturbance induced a complex transient response-characterized by the possible onset of oscillations-before population numbers relaxed to a new steady state. Thus, cell numbers could initially change in the opposite direction of the long-term change. We present quantitative indexes to characterize the transients and to show that the dynamic response is dependent on the degree of synchronization among life stages, which itself depends on the state of the population before perturbation. That is, we show how identical future steady states can be approached via different transients depending on the initial population structure. Our experimental results are supported by a size-structured model that accounts for interplay between cell-cycle and population-level processes and that includes resource-dependent variability in cell size. Our results should be relevant to other populations with a stage structure including organisms of higher order.

  17. Comparison of Single Event Transients Generated by Short Pulsed X-Rays, Lasers and Heavy Ions

    SciTech Connect

    Cardoza, David; LaLumondiere, Stephen D.; Tockstein, Michael A.; Brewe, Dale L.; Wells, Nathan P.; Koga, Rokutaro; Gaab, K. M.; Lotshaw, William T.; Moss, Steven C.

    2014-12-01

    We report an experimental study of the transients generated by pulsed x-rays, heavy ions, and different laser wavelengths in a Si p-i-n photodiode. We compare the charge collected by all of the excitation methods to determine the equivalent LET for pulsed x-rays relative to heavy ions. Our comparisons show that pulsed x-rays from synchrotron sources can generate a large range of equivalent LET and generate transients similar to those excited by laser pulses and heavy ion strikes. We also look at how the pulse width of the transients changes for the different excitation methods. We show that the charge collected with pulsed x-rays is greater than expected as the x-ray photon energy increases. Combined with their capability of focusing to small spot sizes and of penetrating metallization, pulsed x-rays are a promising new tool for high resolution screening of SEE susceptibility

  18. Complex Event Detection in Pedestrian Groups from Uavs

    NASA Astrophysics Data System (ADS)

    Burkert, F.; Butenuth, M.

    2012-07-01

    We present a new hierarchical event detection approach for highly complex scenarios in pedestrian groups on the basis of airborne image sequences from UAVs. Related work on event detection for pedestrians is capable of learning and analyzing recurring motion paths to detect abnormal paths and of analyzing the type of motion interaction between pairs of pedestrians. However, these approaches can only describe basic motion and fail at the analysis of pedestrian groups with complex behavior. We overcome the limitations of the related work by using a dynamic pedestrian graph of a scene which contains basic pairwise pedestrian motion interaction labels in the first layer. In the second layer, pedestrian groups are analyzed based on the dynamic pedestrian graph in order to get higher-level information about group behavior. This is done by a heuristic assignment of predefined scenarios out of a model library to the data. The assignment is based on the motion interaction labels, on dynamic group motion parameters and on a set of subgraph features. Experimental results are shown based on a new UAV dataset which contains group motion of different complexity levels.

  19. A new software on TUG-T60 autonomous telescope for astronomical transient events

    NASA Astrophysics Data System (ADS)

    Dindar, Murat; Helhel, Selçuk; Esenoğlu, Hasan; Parmaksızoğlu, Murat

    2015-03-01

    Robotic telescopes usually run under the control of a scheduler, which provides high-level control by selecting astronomical targets for observation. TÜBİTAK (Scientific and Technological Research Council of Turkey) National Observatory (TUG)-T60 Robotic Telescope is controlled by open-source OCAAS software, formally named Talon. This study introduces new software which was designed for Talon to catch GRB, GAIA and transient alerts. The new GRB software module (daemon process) alertd is running with all other modules of Talon such as telescoped; focus, dome; camerad and telrun. Maximum slew velocity and acceleration limits of the T60 telescope are enough fast for the GRB and transient observations.

  20. Consolidation of Complex Events via Reinstatement in Posterior Cingulate Cortex.

    PubMed

    Bird, Chris M; Keidel, James L; Ing, Leslie P; Horner, Aidan J; Burgess, Neil

    2015-10-28

    It is well-established that active rehearsal increases the efficacy of memory consolidation. It is also known that complex events are interpreted with reference to prior knowledge. However, comparatively little attention has been given to the neural underpinnings of these effects. In healthy adults humans, we investigated the impact of effortful, active rehearsal on memory for events by showing people several short video clips and then asking them to recall these clips, either aloud (Experiment 1) or silently while in an MRI scanner (Experiment 2). In both experiments, actively rehearsed clips were remembered in far greater detail than unrehearsed clips when tested a week later. In Experiment 1, highly similar descriptions of events were produced across retrieval trials, suggesting a degree of semanticization of the memories had taken place. In Experiment 2, spatial patterns of BOLD signal in medial temporal and posterior midline regions were correlated when encoding and rehearsing the same video. Moreover, the strength of this correlation in the posterior cingulate predicted the amount of information subsequently recalled. This is likely to reflect a strengthening of the representation of the video's content. We argue that these representations combine both new episodic information and stored semantic knowledge (or "schemas"). We therefore suggest that posterior midline structures aid consolidation by reinstating and strengthening the associations between episodic details and more generic schematic information. This leads to the creation of coherent memory representations of lifelike, complex events that are resistant to forgetting, but somewhat inflexible and semantic-like in nature. Copyright © 2015 Bird, Keidel et al.

  1. Transient complex oscillations in a closed chemical system with coupled autocatalysis

    NASA Astrophysics Data System (ADS)

    Zhao, Jinpei; Chen, Yu; Wang, Jichang

    2005-03-01

    In this study, hydroquinone was introduced to the classic Belousov-Zhabotinsky (BZ) reaction to build up coupled autocatalytic feedbacks. Various complex dynamical behaviors including successive period-adding bifurcations, irregular oscillations, and frequency modulations were observed in the coupled reaction system. Not only the complexity of oscillations but also the time period during which complex oscillations persist were found to depend greatly on the initial concentration of hydroquinone, which was expected to manifest the coupling strength in the studied system. Dependence of the observed transient complex oscillations on concentrations of ferroin, sulfuric acid, bromate, and malonic acid was also characterized systematically. Numerical simulations with a modified BZ model via incorporating reactions involving hydroquinone and products of hydroquinone qualitatively reproduced the influence of hydroquinone seen in experiments.

  2. The ARTEMIS Catalog of LASCO Coronal Mass Ejections. Automatic Recognition of Transient Events and Marseille Inventory from Synoptic maps

    NASA Astrophysics Data System (ADS)

    Boursier, Y.; Lamy, P.; Llebaria, A.; Goudail, F.; Robelus, S.

    2009-06-01

    The LASCO-C2 coronagraph aboard the SOHO solar observatory has been providing a continuous flow of coronal images since 1996. Synoptic maps for each Carrington rotation have been built from these images, and offer a global view of the temporal evolution of the solar corona, particularly the occurrence of transient events. Coronal Mass Ejections (CMEs) present distinct signatures thus offering a novel approach to the problem of their identification and characterization. We present in this article an automated method of detection based on their morphological appearance on synoptic maps. It is based on adaptive filtering and segmentation, followed by merging with high-level knowledge. The program builds a catalog which lists the CMEs detected for each Carrington Rotation, together with their main estimated parameters: time of appearance, position angle, angular extent, average velocity and intensity. Our final catalog LASCO-ARTEMIS (Automatic Recognition of Transient Events and Marseille Inventory from Synoptic maps) is compared with existing catalogs, CDAW, CACTUS and SEEDS. We find that, likewise the automated CACTUS and SEEDS catalogs, we detect many more events than the CDAW catalog which is based on visual detection. The total number of detected CMEs strongly depends upon the sensitivity to small, faint and numerous events.

  3. Transient extracellular glutamate events in the basolateral amygdala track reward seeking actions

    PubMed Central

    Wassum, KM; Tolosa, VM; Tseng, TC; Balleine, BW; Monbouquette, HG; Maidment, NT

    2012-01-01

    The ability to make rapid, informed decisions about whether or not to engage in a sequence of actions to earn reward is essential for survival. Modeling in rodents has demonstrated a critical role for the basolateral amygdala (BLA) in such reward-seeking actions, but the precise neurochemical underpinnings are not well understood. Taking advantage of recent advancements in biosensor technologies, we made spatially discrete near-real time extracellular recordings of the major excitatory transmitter, glutamate, in the BLA of rats performing a self-paced lever-pressing sequence task for sucrose reward. This allowed us to detect rapid transient fluctuations in extracellular BLA glutamate time-locked to action performance. These glutamate transients tended to precede lever pressing actions and were markedly increased in frequency when rats were engaged in such reward seeking actions. Based on muscimol and tetrodotoxin microinfusions these glutamate transients appeared to originate from the terminals of neurons with cell bodies in the orbital frontal cortex. Importantly, glutamate transient amplitude and frequency fluctuated with the value of the earned reward and positively predicted lever pressing rate. Such novel rapid glutamate recordings during instrumental performance identify a role for glutamatergic signaling within the BLA in instrumental reward-seeking actions. PMID:22357857

  4. The Diagnostic Potential of Transition Region Lines Undergoing Transient Ionization in Dynamic Events

    NASA Astrophysics Data System (ADS)

    Doyle, J. G.; Giunta, A.; Singh, A.; Madjarska, M. S.; Summers, H.; Kellett, B. J.; O'Mullane, M.

    2012-09-01

    We discuss the diagnostic potential of high cadence UV spectral data when transient ionization is considered. For this we use high cadence UV spectra taken during the impulsive phase of a solar flare (observed with instruments on-board the Solar Maximum Mission) which showed excellent correspondence with hard X-ray pulses. The ionization fraction of the transition region ion O v and, in particular, the contribution function for the O v 1371 Å line are computed within the Atomic Data and Analysis Structure, which is a collection of fundamental and derived atomic data and codes to manipulate them. Due to transient ionization, the O v 1371 Å line is enhanced in the first fraction of a second with the peak in the line contribution function occurring initially at a higher electron temperature than in ionization equilibrium. The rise time and enhancement factor depend mostly on the electron density. The fractional increase in the O v 1371 Å emissivity due to transient ionization can reach a factor of two-four and can explain the fast response in the line flux of transition regions ions during the impulsive phase of flares solely as a result of transient ionization. This technique can be used to diagnose the electron temperature and density of solar flares observed with the forthcoming Interface Region Imaging Spectrograph.

  5. Modular X and gamma rays sensor, a space-based instrument for transient lighting events in high atmosphere

    NASA Astrophysics Data System (ADS)

    Reina, M.; Sabau-Graziati, L.; Rodrigo, J. M.; Reglero, V.

    Doing application of the techniques developed on High Energy Gamma rays detection for LEGRI mission of MINISAT satellite, and the experience acquired with INTEGRAL payloads. The scientific and technician team of INTA-GACE is involved into a international consortium, on developing an instrument to detect High Energy Events of very short time duration, similar to Gamma ray burst. Transient Lighting Events (TLE´s), which are present on Terrestrial high atmosphere, and being object of research recently. A space base instrument, to be located on International Space Station (COLUMBUS module), will be enjoy of a superbly location to monitor the earth atmosphere in order to detect those rare events. At same time new detectors and technical challenges are front the team. This article exposes the actual design status and solutions in the MXGS instrument, to give support to gamma sensors.

  6. Electron mobility of rare earth complexes measured by transient electroluminescence method

    NASA Astrophysics Data System (ADS)

    Zang, F. X.; Lengyel, O.; Li, Wenlian; Hong, Z. R.; Liu, Ze; Lee, C. S.; Lee, S. T.

    2006-09-01

    Electron mobility of gadolinium/europium (dibenzoylmethanato) 3(bathophenanthroline) (Gd/Eu(DBM) 3 bath) was measured by transient electroluminescence (EL) method. Although electron mobility of the two complexes were expected to be same, the value of mobility (1.2 × 10 -4 cm 2/Vs at electric field of 1 MV/cm) of Eu(DBM) 3 bath complex was bigger than that (8 × 10 -5 cm 2/Vs at electric field of 1 MV/cm) of Gd(DBM) 3 bath complex. It was found to be related to the different luminescent mechanisms of active materials and recombination zones in the devices. According to this, penetration length of hole injected into electron transport layer of Eu(DBM) 3 bath was estimated.

  7. Multiple Mechanisms of Transient Heating Events in the Protoplanetary Disk: Evidence from Precursors of Chondrules and Igneous Ca,Al-Rich Inclusions

    NASA Astrophysics Data System (ADS)

    Krot, A. N.; Nagashima, K.; Libourel, G.; Miller, K. E.

    2017-02-01

    Here we review the mineralogy, petrography, O-isotope compositions, and trace element abundances of precursors of chondrules and igneous CAIs which provide important constraints on the mechanisms of transient heating events in the protoplanetary disk.

  8. Prolongation of minimal action potential duration in sustained fibrillation decreases complexity by transient destabilization.

    PubMed

    Bingen, Brian O; Askar, Saïd F A; Schalij, Martin J; Kazbanov, Ivan V; Ypey, Dirk L; Panfilov, Alexander V; Pijnappels, Daniël A

    2013-01-01

    Sustained ventricular fibrillation (VF) is maintained by multiple stable rotors. Destabilization of sustained VF could be beneficial by affecting VF complexity (defined by the number of rotors). However, underlying mechanisms affecting VF stability are poorly understood. Therefore, the aim of this study was to correlate changes in arrhythmia complexity with changes in specific electrophysiological parameters, allowing a search for novel factors and underlying mechanisms affecting stability of sustained VF. Neonatal rat ventricular cardiomyocyte monolayers and Langendorff-perfused adult rat hearts were exposed to increasing dosages of the gap junctional uncoupler 2-aminoethoxydiphenyl borate (2-APB) to induce arrhythmias. Ion channel blockers/openers were added to study effects on VF stability. Electrophysiological parameters were assessed by optical mapping and patch-clamp techniques. Arrhythmia complexity in cardiomyocyte cultures increased with increasing dosages of 2-APB (n > 38), leading to sustained VF: 0.0 ± 0.1 phase singularities/cm(2) in controls vs. 0.0 ± 0.1, 1.0 ± 0.9, 3.3 ± 3.2, 11.0 ± 10.1, and 54.3 ± 21.7 in 5, 10, 15, 20, and 25 µmol/L 2-APB, respectively. Arrhythmia complexity inversely correlated with wavelength. Lengthening of wavelength during fibrillation could only be induced by agents (BaCl(2)/BayK8644) increasing the action potential duration (APD) at maximal activation frequencies (minimal APD); 123 ± 32%/117 ± 24% of control. Minimal APD prolongation led to transient VF destabilization, shown by critical wavefront collision leading to rotor termination, followed by significant decreases in VF complexity and activation frequency (52%/37%). These key findings were reproduced ex vivo in rat hearts (n = 6 per group). These results show that stability of sustained fibrillation is regulated by minimal APD. Minimal APD prolongation leads to transient destabilization of fibrillation, ultimately decreasing VF complexity, thereby providing

  9. Transient weak protein-protein complexes transfer heme across the cell wall of Staphylococcus aureus.

    PubMed

    Villareal, Valerie A; Spirig, Thomas; Robson, Scott A; Liu, Mengyao; Lei, Benfang; Clubb, Robert T

    2011-09-14

    Iron is an essential nutrient for the bacterial pathogen Staphylococcus aureus . Heme in hemoglobin (Hb) is the most abundant source of iron in the human body and during infections is captured by S. aureus using iron-regulated surface determinant (Isd) proteins. A central step in this process is the transfer of heme between the cell wall associated IsdA and IsdC hemoproteins. Biochemical evidence indicates that heme is transferred via an activated IsdA:heme:IsdC heme complex. Transfer is rapid and occurs up to 70,000 times faster than indirect mechanisms in which heme is released into the solvent. To gain insight into the mechanism of transfer, we modeled the structure of the complex using NMR paramagnetic relaxation enhancement (PRE) methods. Our results indicate that IsdA and IsdC transfer heme via an ultraweak affinity "handclasp" complex that juxtaposes their respective 3(10) helices and β7/β8 loops. Interestingly, PRE also identified a set of transient complexes that could represent high-energy pre-equilibrium encounter species that form prior to the stereospecific handclasp complex. Targeted amino acid mutagenesis and stopped-flow measurements substantiate the functional relevance of a PRE-derived model, as mutation of interfacial side chains significantly slows the rate of transfer. IsdA and IsdC bind heme using NEAr Transporter (NEAT) domains that are conserved in many species of pathogenic Gram-positive bacteria. Heme transfer in these microbes may also occur through structurally similar transient stereospecific complexes.

  10. Weak conservation of structural features in the interfaces of homologous transient protein-protein complexes.

    PubMed

    Sudha, Govindarajan; Singh, Prashant; Swapna, Lakshmipuram S; Srinivasan, Narayanaswamy

    2015-11-01

    Residue types at the interface of protein-protein complexes (PPCs) are known to be reasonably well conserved. However, we show, using a dataset of known 3-D structures of homologous transient PPCs, that the 3-D location of interfacial residues and their interaction patterns are only moderately and poorly conserved, respectively. Another surprising observation is that a residue at the interface that is conserved is not necessarily in the interface in the homolog. Such differences in homologous complexes are manifested by substitution of the residues that are spatially proximal to the conserved residue and structural differences at the interfaces as well as differences in spatial orientations of the interacting proteins. Conservation of interface location and the interaction pattern at the core of the interfaces is higher than at the periphery of the interface patch. Extents of variability of various structural features reported here for homologous transient PPCs are higher than the variation in homologous permanent homomers. Our findings suggest that straightforward extrapolation of interfacial nature and inter-residue interaction patterns from template to target could lead to serious errors in the modeled complex structure. Understanding the evolution of interfaces provides insights to improve comparative modeling of PPC structures.

  11. Weak conservation of structural features in the interfaces of homologous transient protein–protein complexes

    PubMed Central

    Sudha, Govindarajan; Singh, Prashant; Swapna, Lakshmipuram S; Srinivasan, Narayanaswamy

    2015-01-01

    Residue types at the interface of protein–protein complexes (PPCs) are known to be reasonably well conserved. However, we show, using a dataset of known 3-D structures of homologous transient PPCs, that the 3-D location of interfacial residues and their interaction patterns are only moderately and poorly conserved, respectively. Another surprising observation is that a residue at the interface that is conserved is not necessarily in the interface in the homolog. Such differences in homologous complexes are manifested by substitution of the residues that are spatially proximal to the conserved residue and structural differences at the interfaces as well as differences in spatial orientations of the interacting proteins. Conservation of interface location and the interaction pattern at the core of the interfaces is higher than at the periphery of the interface patch. Extents of variability of various structural features reported here for homologous transient PPCs are higher than the variation in homologous permanent homomers. Our findings suggest that straightforward extrapolation of interfacial nature and inter-residue interaction patterns from template to target could lead to serious errors in the modeled complex structure. Understanding the evolution of interfaces provides insights to improve comparative modeling of PPC structures. PMID:26311309

  12. Interrelationships between yeast ribosomal protein assembly events and transient ribosome biogenesis factors interactions in early pre-ribosomes.

    PubMed

    Jakob, Steffen; Ohmayer, Uli; Neueder, Andreas; Hierlmeier, Thomas; Perez-Fernandez, Jorge; Hochmuth, Eduard; Deutzmann, Rainer; Griesenbeck, Joachim; Tschochner, Herbert; Milkereit, Philipp

    2012-01-01

    Early steps of eukaryotic ribosome biogenesis require a large set of ribosome biogenesis factors which transiently interact with nascent rRNA precursors (pre-rRNA). Most likely, concomitant with that initial contacts between ribosomal proteins (r-proteins) and ribosome precursors (pre-ribosomes) are established which are converted into robust interactions between pre-rRNA and r-proteins during the course of ribosome maturation. Here we analysed the interrelationship between r-protein assembly events and the transient interactions of ribosome biogenesis factors with early pre-ribosomal intermediates termed 90S pre-ribosomes or small ribosomal subunit (SSU) processome in yeast cells. We observed that components of the SSU processome UTP-A and UTP-B sub-modules were recruited to early pre-ribosomes independently of all tested r-proteins. On the other hand, groups of SSU processome components were identified whose association with early pre-ribosomes was affected by specific r-protein assembly events in the head-platform interface of the SSU. One of these components, Noc4p, appeared to be itself required for robust incorporation of r-proteins into the SSU head domain. Altogether, the data reveal an emerging network of specific interrelationships between local r-protein assembly events and the functional interactions of SSU processome components with early pre-ribosomes. They point towards some of these components being transient primary pre-rRNA in vivo binders and towards a role for others in coordinating the assembly of major SSU domains.

  13. Modeling from Local to Subsystem Level Effects in Analog and Digital Circuits Due to Space Induced Single Event Transients

    NASA Technical Reports Server (NTRS)

    Perez, Reinaldo J.

    2011-01-01

    Single Event Transients in analog and digital electronics from space generated high energetic nuclear particles can disrupt either temporarily and sometimes permanently the functionality and performance of electronics in space vehicles. This work first provides some insights into the modeling of SET in electronic circuits that can be used in SPICE-like simulators. The work is then directed to present methodologies, one of which was developed by this author, for the assessment of SET at different levels of integration in electronics, from the circuit level to the subsystem level.

  14. Transient crustal movement in the northern Izu-Bonin arc starting in 2004: A large slow slip event or a slow back-arc rifting event?

    NASA Astrophysics Data System (ADS)

    Arisa, Deasy; Heki, Kosuke

    2016-07-01

    The Izu-Bonin arc lies along the convergent boundary where the Pacific Plate subducts beneath the Philippine Sea Plate. Horizontal velocities of continuous Global Navigation Satellite System stations on the Izu Islands move eastward by up to 1 cm/year relative to the stable part of the Philippine Sea Plate suggesting active back-arc rifting behind the northern part of the arc. Here, we report that such eastward movements transiently accelerated in the middle of 2004 resulting in 3 cm extra movements in 3 years. We compare three different mechanisms possibly responsible for this transient movement, i.e. (1) postseismic movement of the 2004 September earthquake sequence off the Kii Peninsula far to the west, (2) a temporary activation of the back-arc rifting to the west dynamically triggered by seismic waves from a nearby earthquake, and (3) a large slow slip event in the Izu-Bonin Trench to the east. By comparing crustal movements in different regions, the first possibility can be shown unlikely. It is difficult to rule out the second possibility, but current evidence support the third possibility, i.e. a large slow slip event with moment magnitude of 7.5 may have occurred there.

  15. DEdicated MONitor of EXotransits and Transients (DEMONEXT): a low-cost robotic and automated telescope for followup of exoplanetary transits and other transient events

    NASA Astrophysics Data System (ADS)

    Villanueva, S.; Eastman, J. D.; Gaudi, B. S.; Pogge, R. W.; Stassun, K. G.; Trueblood, M.; Trueblood, P.

    2016-07-01

    We present the design and development of the DEdicatedMONitor of EXotransits and Transients (DEMONEXT), an automated and robotic 20 inch telescope jointly funded by The Ohio State University and Vanderbilt University. The telescope is a PlaneWave CDK20 f/6.8 Corrected Dall-Kirkham Astrograph telescope on a Mathis Instruments MI-750/1000 Fork Mount located atWiner Observatory in Sonoita, AZ. DEMONEXT has a Hedrick electronic focuser, Finger Lakes Instrumentation (FLI) CFW-3-10 filter wheel, and a 2048 x 2048 pixel FLI Proline CCD3041 camera with a pixel scale of 0.90 arc-seconds per pixel and a 30.7× 30.7 arc-minute field-of-view. The telescope's automation, controls, and scheduling are implemented in Python, including a facility to add new targets in real time for rapid follow-up of time-critical targets. DEMONEXT will be used for the confirmation and detailed investigation of newly discovered planet candidates from the Kilodegree Extremely Little Telescope (KELT) survey, exploration of the atmospheres of Hot Jupiters via transmission spectroscopy and thermal emission measurements, and monitoring of select eclipsing binary star systems as benchmarks for models of stellar evolution. DEMONEXT will enable rapid confirmation imaging of supernovae, flare stars, tidal disruption events, and other transients discovered by the All Sky Automated Survey for SuperNovae (ASAS-SN). DEMONEXT will also provide follow-up observations of single-transit planets identified by the Transiting Exoplanet Survey Satellite (TESS) mission, and to validate long-period eclipsing systems discovered by Gaia.

  16. Single Event Transient Analysis of an SOI Operational Amplifier for Use in Low-Temperature Martian Exploration

    NASA Technical Reports Server (NTRS)

    Laird, Jamie S.; Scheik, Leif; Vizkelethy, Gyorgy; Mojarradi, Mohammad M; Chen, Yuan; Miyahira, Tetsuo; Blalock, Benjamin; Greenwell, Robert; Doyle, Barney

    2006-01-01

    The next generation of Martian rover#s to be launched by JPL are to examine polar regions where temperatures are extremely low and the absence of an earth-like atmosphere results in high levels of cosmic radiation at ground level. Cosmic rays lead to a plethora of radiation effects including Single Event Transients (SET) which can severely degrade microelectronic functionality. As such, a radiation-hardened, temperature compensated CMOS Single-On-Insulator (SOI) Operational Amplifier has been designed for JPL by the University of Tennessee and fabricated by Honeywell using the SOI V process. SOI technology has been shownto be far less sensitive to transient effects than both bulk and epilayer Si. Broad beam heavy-ion tests at the University of Texas A&M using Kr and Xebeams of energy 25MeV/amu were performed to ascertain the duration and severity of the SET for the op-amp configured for a low and high gain application. However, some ambiguity regarding the location of transient formation required the use of a focused MeV ion microbeam. A 36MeV O6(+) microbeam. the Sandia National Laboratory (SNL) was used to image and verify regions of particular concern. This is a viewgraph presentation

  17. Steady-State Visual Evoked Potentials Can Be Explained by Temporal Superposition of Transient Event-Related Responses

    PubMed Central

    Capilla, Almudena; Pazo-Alvarez, Paula; Darriba, Alvaro; Campo, Pablo; Gross, Joachim

    2011-01-01

    Background One common criterion for classifying electrophysiological brain responses is based on the distinction between transient (i.e. event-related potentials, ERPs) and steady-state responses (SSRs). The generation of SSRs is usually attributed to the entrainment of a neural rhythm driven by the stimulus train. However, a more parsimonious account suggests that SSRs might result from the linear addition of the transient responses elicited by each stimulus. This study aimed to investigate this possibility. Methodology/Principal Findings We recorded brain potentials elicited by a checkerboard stimulus reversing at different rates. We modeled SSRs by sequentially shifting and linearly adding rate-specific ERPs. Our results show a strong resemblance between recorded and synthetic SSRs, supporting the superposition hypothesis. Furthermore, we did not find evidence of entrainment of a neural oscillation at the stimulation frequency. Conclusions/Significance This study provides evidence that visual SSRs can be explained as a superposition of transient ERPs. These findings have critical implications in our current understanding of brain oscillations. Contrary to the idea that neural networks can be tuned to a wide range of frequencies, our findings rather suggest that the oscillatory response of a given neural network is constrained within its natural frequency range. PMID:21267081

  18. Single Event Transient Analysis of an SOI Operational Amplifier for Use in Low-Temperature Martian Exploration

    NASA Technical Reports Server (NTRS)

    Laird, Jamie S.; Scheik, Leif; Vizkelethy, Gyorgy; Mojarradi, Mohammad M; Chen, Yuan; Miyahira, Tetsuo; Blalock, Benjamin; Greenwell, Robert; Doyle, Barney

    2006-01-01

    The next generation of Martian rover#s to be launched by JPL are to examine polar regions where temperatures are extremely low and the absence of an earth-like atmosphere results in high levels of cosmic radiation at ground level. Cosmic rays lead to a plethora of radiation effects including Single Event Transients (SET) which can severely degrade microelectronic functionality. As such, a radiation-hardened, temperature compensated CMOS Single-On-Insulator (SOI) Operational Amplifier has been designed for JPL by the University of Tennessee and fabricated by Honeywell using the SOI V process. SOI technology has been shownto be far less sensitive to transient effects than both bulk and epilayer Si. Broad beam heavy-ion tests at the University of Texas A&M using Kr and Xebeams of energy 25MeV/amu were performed to ascertain the duration and severity of the SET for the op-amp configured for a low and high gain application. However, some ambiguity regarding the location of transient formation required the use of a focused MeV ion microbeam. A 36MeV O6(+) microbeam. the Sandia National Laboratory (SNL) was used to image and verify regions of particular concern. This is a viewgraph presentation

  19. High-Speed Single-Event Current Transient Measurements in SiGe HBTs

    NASA Technical Reports Server (NTRS)

    Pellish, Jonathan A.; Reed, R.A.; McMorrow, D.; Vizkelethy, G.; Ferlet-Cavrois, V.; Baggio, J.; Paillet, P.; Duhamel, O.; Phillips, S.D.; Sutton, A.K.; hide

    2009-01-01

    Time-resolved ion beam induced charge reveals heavy ion response of IBM 5AM SiGe HBT: 1) Position correlation. 2) Unique response for different bias schemes. 3) Similarities to TPA pulsed-laser data. Heavy ion broad-beam transients provide more realistic device response: 1) Feedback using microbeam data 2) Overcome existing issues of LET and ion range with microbeam Both micro- and broad-beam data sets yield valuable input for TCAD simulations. Uncover detailed mechanisms for SiGe HBTs and other devices fabricated on lightly-doped substrates.

  20. Optical interferometric observations of a transient event of 1986 March 13 in the coma of Comet Halley

    NASA Astrophysics Data System (ADS)

    Debi Prasad, C.; Chandrasekhar, T.; Desai, J. N.; Ashok, N. M.; Krishan, Vinod

    1989-03-01

    During the recent apparition of Comet Halley in 1985-86, a transient ionic event in the form of a blob of H2O(+) emission was recorded in the coma at about 0 h UT on March 13, 1986. Observations were carried out using a special filter for H2O(+) emission at 7000 A/175 A, a 35-cm telescope, a Fabry-Perot interferometer, and an image intensifier camera from Gurushikhar, Mt. Abu. A Fabry-Perot interferogram in H-alpha taken a few minutes later at the same location, reveals strong hydrogen emission (H-alpha) associated with the blob. The velocity field in the blob is structured with relative velocities up to about 35 km/sec. The event is interpreted as arising due to the sector boundary crossing of the interplanetary magnetic field by the comet.

  1. Investigation of single-event transient mitigation via pulse quenching in logic circuits

    NASA Astrophysics Data System (ADS)

    Luo, Sheng; He, Wei; Zhang, Zhun; He, Lingxiang; Cao, Jianmin; Wu, Qingyang

    2017-06-01

    A layout technique which can mitigate single-event effect via pulse quenching is tested in this paper. The new limitation of application of this layout technique is affirmed in 65nm technology. The layout design via pulse quenching has no effects in PMOS, but it can work in NMOS in basic logical circuits. Combinational logic circuits still can use this method to defense single-event effect.

  2. Ground motion: frequency of occurrence versus amplitude of disturbing transient events

    SciTech Connect

    Werner, K.L.

    1983-09-12

    Successful collider operation requires that ground motion not exceed certain tolerances. In this note it is pointed out that on occasion these tolerances are exceeded. The frequency of such events and their amplitudes, measured as a function of time of day, have been measured. An examination of the data leads one to conclude that most events are of cultural (i.e., man-made) origin. 2 references, 20 figures.

  3. A transient event in AD 775 reported by al-Tabarı: A bolide - not a nova, supernova, or kilonova

    NASA Astrophysics Data System (ADS)

    Neuhäuser, R.; Kunitzsch, P.

    2014-11-01

    Given that the cause for the strong increase in 14C in AD 774/5 in Japanese and German trees is still a matter of debate (e.g. short gamma-ray burst or solar super-flare), we have searched in Arabic chronicles for reports about unusual transient celestial events. In the History of al-Tabarı we found two (almost identical) reports about such an event. The group around caliph al-Mansūr observed a transient event while on the way from Baghdad to Mecca on AD 775 Augusst 29 - September 1 (Julian calendar). A celestial object (kawkab) was seen to fall or set (inqadda), and its trace (atharuhu) was seen for at least tens of minutes (up to 70-90 min) during morning twilight. The reports use the Arabic words kawkab and athar(uhu), which were also used in the known Arabic reports about supernovae SN 1006 and 1054, so that one might consider an interpretation as a nova-like event. The kawkab (celestial object) was observed only during the morning twilight at a brightness of probably between about -3 and 0 mag. Such a brightness and time-scale would be expected for optical kilonovae (at {˜ 3} to 9 kpc) in the context of short gamma-ray bursts. There are no similar reports from eastern Asia for this time. However, the short reports are fully consistent with a bolide: The word kawkab can be used for meteor, the verb inqadda normally means falling down, the word atharuhu can mean its trace. We therefore prefer the interpretation as bolide. We discuss in detail how to convert the Muslim calendar date to a date in the Julian calendar using first the calculated Islamic calendar and then considering the time when the crescent new moon could be visible at the given location.

  4. Fast transient absorption spectroscopy of the early events in photoexcited chiral benzophenone naphthalene dyads

    NASA Astrophysics Data System (ADS)

    Perez-Ruiz, Raul; Groeneveld, Michiel; van Stokkum, Ivo H. M.; Tormos, Rosa; Williams, René M.; Miranda, Miguel A.

    2006-09-01

    Photoinduced intra-molecular energy transfer in two ketoprofen(KP)-naproxol(NPX) diastereomers proceeds via two pathways. Very fast singlet-triplet energy transfer ( k = 1.2 × 10 11 s -1) from KP to NPX occurs for a small percentage (6%) and the major pathway is triplet-triplet energy transfer ( k ˜ 3 × 10 9 s -1). This was shown with femtosecond transient absorption spectroscopy and global and target analysis. Whereas the NPX triplet decay is strongly stereospecific (ratio of 1.6), the NPX triplet state formation for both dyads is very similar (ratio of 1 for the fast process and 1.2 for the slower process).

  5. Modeling of single event transients with dual double-exponential current sources: Implications for logic cell characterization

    DOE PAGES

    Black, Dolores Archuleta; Robinson, William H.; Wilcox, Ian Zachary; ...

    2015-08-07

    Single event effects (SEE) are a reliability concern for modern microelectronics. Bit corruptions can be caused by single event upsets (SEUs) in the storage cells or by sampling single event transients (SETs) from a logic path. Likewise, an accurate prediction of soft error susceptibility from SETs requires good models to convert collected charge into compact descriptions of the current injection process. This paper describes a simple, yet effective, method to model the current waveform resulting from a charge collection event for SET circuit simulations. The model uses two double-exponential current sources in parallel, and the results illustrate why a conventionalmore » model based on one double-exponential source can be incomplete. Furthermore, a small set of logic cells with varying input conditions, drive strength, and output loading are simulated to extract the parameters for the dual double-exponential current sources. As a result, the parameters are based upon both the node capacitance and the restoring current (i.e., drive strength) of the logic cell.« less

  6. Modeling of single event transients with dual double-exponential current sources: Implications for logic cell characterization

    SciTech Connect

    Black, Dolores Archuleta; Robinson, William H.; Wilcox, Ian Zachary; Limbrick, Daniel B.; Black, Jeffrey D.

    2015-08-07

    Single event effects (SEE) are a reliability concern for modern microelectronics. Bit corruptions can be caused by single event upsets (SEUs) in the storage cells or by sampling single event transients (SETs) from a logic path. Likewise, an accurate prediction of soft error susceptibility from SETs requires good models to convert collected charge into compact descriptions of the current injection process. This paper describes a simple, yet effective, method to model the current waveform resulting from a charge collection event for SET circuit simulations. The model uses two double-exponential current sources in parallel, and the results illustrate why a conventional model based on one double-exponential source can be incomplete. Furthermore, a small set of logic cells with varying input conditions, drive strength, and output loading are simulated to extract the parameters for the dual double-exponential current sources. As a result, the parameters are based upon both the node capacitance and the restoring current (i.e., drive strength) of the logic cell.

  7. Study of ionospheric disturbances over Mexico associated with transient space weather events

    NASA Astrophysics Data System (ADS)

    Romero-Hernandez, E.; Gonzalez-Esparza, J. A.; Rodriguez-Martinez, M.; Sergeeva, M. A.; Aguilar-Rodriguez, E.; Mejia-Ambriz, J. C.; De la Luz, V.

    2017-10-01

    We present an analysis of ionospheric disturbances at a location in Mexico (dip latitude: 28 ° , geographic latitude: 19 ° N) using two different parameters: ionospheric scintillation (IONS) and Total Electron Content (TEC). This study employs observations during 2014-2015 of astronomical radio sources at 140 MHz obtained by the MEXican Array Radio Telescope (MEXART) and TEC values from Global Ionospheric Maps data. To identify the ionospheric disturbances two indices were used: the wavelet IONS index based on the wavelet transform function of MEXART data and the ionospheric W-index based on the deviation of TEC. A set of 55 wavelet IONS events and 63 W-index events were identified in this interval. We analyzed the association of theses events with solar flares that occurred around the solar zenith and/or geomagnetic storms. During this period, it was observed an incidence of daytime IONS at hours around the solar zenith. Some possible associations with solar flares were found. The preliminary results pointed out that, for this period, daytime scintillations could be linked to the occurrence of Esb -layers. In addition, most of the W-index events were possibly related to geomagnetic storms. We found that the majority of these geomagnetic storms were minor and moderate storms and were characterized by steeper falls of Dst. This first analysis revealed that wavelet methodology is useful in identifying and analyzing ionospheric disturbances. Also, MEXART observations provide a good tool for performing IONS studies at mid latitudes.

  8. Persistent versus transient tree encroachment of temperate peat bogs: effects of climate warming and drought events.

    PubMed

    Heijmans, Monique M P D; van der Knaap, Yasmijn A M; Holmgren, Milena; Limpens, Juul

    2013-07-01

    Peatlands store approximately 30% of global soil carbon, most in moss-dominated bogs. Future climatic changes, such as changes in precipitation patterns and warming, are expected to affect peat bog vegetation composition and thereby its long-term carbon sequestration capacity. Theoretical work suggests that an episode of rapid environmental change is more likely to trigger transitions to alternative ecosystem states than a gradual, but equally large, change in conditions. We used a dynamic vegetation model to explore the impacts of drought events and increased temperature on vegetation composition of temperate peat bogs. We analyzed the consequences of six patterns of summer drought events combined with five temperature scenarios to test whether an open peat bog dominated by moss (Sphagnum) could shift to a tree-dominated state. Unexpectedly, neither a gradual decrease in the amount of summer precipitation nor the occurrence of a number of extremely dry summers in a row could shift the moss-dominated peat bog permanently into a tree-dominated peat bog. The increase in tree biomass during drought events was unable to trigger positive feedbacks that keep the ecosystem in a tree-dominated state after a return to previous 'normal' rainfall conditions. In contrast, temperature increases from 1 °C onward already shifted peat bogs into tree-dominated ecosystems. In our simulations, drought events facilitated tree establishment, but temperature determined how much tree biomass could develop. Our results suggest that under current climatic conditions, peat bog vegetation is rather resilient to drought events, but very sensitive to temperature increases, indicating that future warming is likely to trigger persistent vegetation shifts. © 2013 Blackwell Publishing Ltd.

  9. Potential of mean force and transient states in polyelectrolyte pair complexation.

    PubMed

    Xu, Xiao; Kanduč, Matej; Wu, Jianzhong; Dzubiella, Joachim

    2016-07-21

    The pair association between two polyelectrolytes (PEs) of the same size but opposite charge is systematically studied in terms of the potential of mean force (PMF) along their center-of-mass reaction coordinate via coarse-grained, implicit-solvent, explicit-salt computer simulations. The focus is set on the onset and the intermediate transient stages of complexation. At conditions above the counterion-condensation threshold, the PE association process exhibits a distinct sliding-rod-like behavior where the polymer chains approach each other by first stretching out at a critical distance close to their contour length, then "shaking hand" and sliding along each other in a parallel fashion, before eventually folding into a neutral complex. The essential part of the PMF for highly charged PEs can be very well described by a simple theory based on sliding charged "Debye-Hückel" rods with renormalized charges in addition to an explicit entropy contribution owing to the release of condensed counterions. Interestingly, at the onset of complex formation, the mean force between the PE chains is found to be discontinuous, reflecting a bimodal structural behavior that arises from the coexistence of interconnected-rod and isolated-coil states. These two microstates of the PE complex are balanced by subtle counterion release effects and separated by a free-energy barrier due to unfavorable stretching entropy.

  10. Potential of mean force and transient states in polyelectrolyte pair complexation

    NASA Astrophysics Data System (ADS)

    Xu, Xiao; Kanduč, Matej; Wu, Jianzhong; Dzubiella, Joachim

    2016-07-01

    The pair association between two polyelectrolytes (PEs) of the same size but opposite charge is systematically studied in terms of the potential of mean force (PMF) along their center-of-mass reaction coordinate via coarse-grained, implicit-solvent, explicit-salt computer simulations. The focus is set on the onset and the intermediate transient stages of complexation. At conditions above the counterion-condensation threshold, the PE association process exhibits a distinct sliding-rod-like behavior where the polymer chains approach each other by first stretching out at a critical distance close to their contour length, then "shaking hand" and sliding along each other in a parallel fashion, before eventually folding into a neutral complex. The essential part of the PMF for highly charged PEs can be very well described by a simple theory based on sliding charged "Debye-Hückel" rods with renormalized charges in addition to an explicit entropy contribution owing to the release of condensed counterions. Interestingly, at the onset of complex formation, the mean force between the PE chains is found to be discontinuous, reflecting a bimodal structural behavior that arises from the coexistence of interconnected-rod and isolated-coil states. These two microstates of the PE complex are balanced by subtle counterion release effects and separated by a free-energy barrier due to unfavorable stretching entropy.

  11. Transient cerebral hypoperfusion and hypertensive events during atrial fibrillation: a plausible mechanism for cognitive impairment

    PubMed Central

    Anselmino, Matteo; Scarsoglio, Stefania; Saglietto, Andrea; Gaita, Fiorenzo; Ridolfi, Luca

    2016-01-01

    Atrial fibrillation (AF) is associated with an increased risk of dementia and cognitive decline, independent of strokes. Several mechanisms have been proposed to explain this association, but altered cerebral blood flow dynamics during AF has been poorly investigated: in particular, it is unknown how AF influences hemodynamic parameters of the distal cerebral circulation, at the arteriolar and capillary level. Two coupled lumped-parameter models (systemic and cerebrovascular circulations, respectively) were here used to simulate sinus rhythm (SR) and AF. For each simulation 5000 cardiac cycles were analyzed and cerebral hemodynamic parameters were calculated. With respect to SR, AF triggered a higher variability of the cerebral hemodynamic variables which increases proceeding towards the distal circulation, reaching the maximum extent at the arteriolar and capillary levels. This variability led to critical cerebral hemodynamic events of excessive pressure or reduced blood flow: 303 hypoperfusions occurred at the arteriolar level, while 387 hypertensive events occurred at the capillary level during AF. By contrast, neither hypoperfusions nor hypertensive events occurred during SR. Thus, the impact of AF per se on cerebral hemodynamics candidates as a relevant mechanism into the genesis of AF-related cognitive impairment/dementia. PMID:27334559

  12. Transient cerebral hypoperfusion and hypertensive events during atrial fibrillation: a plausible mechanism for cognitive impairment

    NASA Astrophysics Data System (ADS)

    Anselmino, Matteo; Scarsoglio, Stefania; Saglietto, Andrea; Gaita, Fiorenzo; Ridolfi, Luca

    2016-06-01

    Atrial fibrillation (AF) is associated with an increased risk of dementia and cognitive decline, independent of strokes. Several mechanisms have been proposed to explain this association, but altered cerebral blood flow dynamics during AF has been poorly investigated: in particular, it is unknown how AF influences hemodynamic parameters of the distal cerebral circulation, at the arteriolar and capillary level. Two coupled lumped-parameter models (systemic and cerebrovascular circulations, respectively) were here used to simulate sinus rhythm (SR) and AF. For each simulation 5000 cardiac cycles were analyzed and cerebral hemodynamic parameters were calculated. With respect to SR, AF triggered a higher variability of the cerebral hemodynamic variables which increases proceeding towards the distal circulation, reaching the maximum extent at the arteriolar and capillary levels. This variability led to critical cerebral hemodynamic events of excessive pressure or reduced blood flow: 303 hypoperfusions occurred at the arteriolar level, while 387 hypertensive events occurred at the capillary level during AF. By contrast, neither hypoperfusions nor hypertensive events occurred during SR. Thus, the impact of AF per se on cerebral hemodynamics candidates as a relevant mechanism into the genesis of AF-related cognitive impairment/dementia.

  13. Modeling the Complex Dynamics and Changing Correlations of Epileptic Events

    PubMed Central

    Wulsin, Drausin F.; Fox, Emily B.; Litt, Brian

    2014-01-01

    Patients with epilepsy can manifest short, sub-clinical epileptic “bursts” in addition to full-blown clinical seizures. We believe the relationship between these two classes of events—something not previously studied quantitatively—could yield important insights into the nature and intrinsic dynamics of seizures. A goal of our work is to parse these complex epileptic events into distinct dynamic regimes. A challenge posed by the intracranial EEG (iEEG) data we study is the fact that the number and placement of electrodes can vary between patients. We develop a Bayesian nonparametric Markov switching process that allows for (i) shared dynamic regimes between a variable number of channels, (ii) asynchronous regime-switching, and (iii) an unknown dictionary of dynamic regimes. We encode a sparse and changing set of dependencies between the channels using a Markov-switching Gaussian graphical model for the innovations process driving the channel dynamics and demonstrate the importance of this model in parsing and out-of-sample predictions of iEEG data. We show that our model produces intuitive state assignments that can help automate clinical analysis of seizures and enable the comparison of sub-clinical bursts and full clinical seizures. PMID:25284825

  14. Suppression of Transient Events by Levitation (STABLE): Results From the USML-2 Mission. Experiment 38

    NASA Technical Reports Server (NTRS)

    Nurre, Gerald S.; Edberg, Donald L.

    1998-01-01

    Microgravity science payloads can be extremely sensitive to vibrations from machinery, acoustics, ventilation, and crew activity. Suppression of Transient Acceleration by Levitation (STABLE) is an active vibration isolation system designed to protect payloads from these disturbances. This paper gives an account of results from the flight demonstration of the STABLE microgravity isolation system, which was developed and successfully flight tested in orbit during USML-2, with the participation of Astronaut Fred Leslie. Following a very brief description of the operational principles, the hardware and software design, and performance criteria, results of the analysis of measured flight data are presented to provide an evaluation of system performance parameters, including acceleration attenuation, assessment of sway space, system power consumption, and other factors critical to the performance of an isolation system. Lessons learned and potential design improvements and evolutions are discussed. Data reduction by Robert Boucher of McDonnell Douglas Aerospace (MDA) was substantially assisted by Kenneth Hrovat of Tal-Cut, Inc., under support from National Aeronautics and Space Administration/Lewis Research Center (LeRC), Cleveland, OH.

  15. Single-event-transient effects in sub-70 nm bulk and SOI FinFETs

    NASA Astrophysics Data System (ADS)

    El Mamouni, Farah

    After fourteen years of research and investigations by engineers in the university and industry communities, FinFET devices are finally ready to use in products [1-2]. FinFET technologies have been demonstrated to outperform planar technologies for high speed, low power and high performance applications, while maintaining the shrinking trends of microelectronics (beyond 32 nm) for at least the next two to three technology generations. These promising findings were enough for leading chip manufacturers like Intel to announce their plans to mass-produce FinFETs in the near future [3-4]. However, the device response in extreme environments (i.e., space) is still not well understood. Exploring the behavior of FinFETs in such environments is also important for the aerospace and medical industries, where unhardened commercial off the shelf (COTS) electronics are used. The objective of this work is to explore the transient electrical behavior of FinFET devices in both bulk and SOI technologies in radiation-rich environments through laser and heavy ion testing. A further objective of this work is to contribute to improving the performance of FinFET devices, in particular in harsh environments. Indeed, the new results obtained in this work identify the physical regions in the devices that are most sensitive to radiation effects and how they affect the radiation response. The findings will help engineers to design new generations of FinFET devices with higher tolerance to radiation effects.

  16. Time-Critical Studies: Rapid response to Transient Dynamic Mid-Ocean Ridge Events

    NASA Astrophysics Data System (ADS)

    Dziak, R. P.; Cowen, J. P.; Baker, E. T.; Bohnenstiehl, D. R.

    2005-12-01

    The Time-Critical Studies (TCS) Theme of Ridge 2000 focuses on observations of the immediate geochemical and geobiological consequences of magmatic and tectonic events along the global mid-ocean ridge system. NOAA's T-Phase Monitoring Program has accessed the U.S. Navy's NE SOSUS data in real-time since 1993, providing the TCS community with detection of seismicity associated with eruptive or tectonic activity along the Juan de Fuca (JFR) and Gorda Ridges. This remote detection of earthquake swarms, coupled to NSF and NOAA funding for pre-event staging of equipment and supplies, allows directed and increasingly well-organized field responses to event sites. On 27 February 2005, one of the largest submarine earthquake sequences recorded with SOSUS occurred at the Endeavour segment of the JFR. The swarm met all criteria for magmatic earthquake sequences (see Dziak et al. poster and upcoming EOS article). This swarm differed from other plume-producing swarms in that it migrated more slowly (< 0.1 m/s) and over less distance (< 30 km) and occurred entirely within an overlap zone rather than within the bathymetric minimum of a segment. Despite the ambiguous character of the earthquake swarm, the Event Response Community responded since: (1) Although the swarm appeared to be magmatic, there is no way to confirm seafloor or water-column effects without in situ observations; and (2) absent a seafloor eruption, the physical process of injecting magma into the crust should cause significant faulting and fissuring that could result in the release of hydrothermal fluids. The high intensity of the earthquake swarm greatly increased this possibility. This response effort marked the sixth time since 1993 that a research cruise was organized for rapid response to the site of earthquake activity. The response team was on station just 6 days after notification of the seismic swarm, the fastest response yet mounted. Although the team detected no evidence of a new lava flow, or event

  17. Emission and fs/ns-TRANSIENT Absorption of Organometallic Complexes Bound to a Dinuclear Metal Center

    NASA Astrophysics Data System (ADS)

    Durr, Christopher B.; Brown-Xu, Samantha E.; Chisholm, Malcolm H.

    2012-06-01

    Compounds containing a MM quadruple bond (M = Mo or W) of the form M2L2L'2, where L and L' are conjugated organic ligands, show interesting photophysical properties along with a metal-to-ligand charge transfer (MLCT) band that is tunable throughout the UV-Vis-NIR spectra. Recently, our attention has shifted towards ligands that incorporate a secondary transition metal complex bound to an organic moiety. Along with allowing for a second tunable MLCT band for better coverage of the solar spectrum, these hybrid molecules show unique spectroscopic properties that were explored using fs/ns-transient absorption and UV-Vis/NIR emission. These techniques allow for the elucidation of the electronic character of the excited states as well as their lifetimes. This knowledge will be put to use in the design of new materials that could later be incorporated into next generation photovoltaic devices.

  18. Mediterranean circulation perturbations over the last five centuries: Relevance to past Eastern Mediterranean Transient-type events

    NASA Astrophysics Data System (ADS)

    Incarbona, Alessandro; Martrat, Belen; Mortyn, P. Graham; Sprovieri, Mario; Ziveri, Patrizia; Gogou, Alexandra; Jordà, Gabriel; Xoplaki, Elena; Luterbacher, Juerg; Langone, Leonardo; Marino, Gianluca; Rodríguez-Sanz, Laura; Triantaphyllou, Maria; di Stefano, Enrico; Grimalt, Joan O.; Tranchida, Giorgio; Sprovieri, Rodolfo; Mazzola, Salvatore

    2016-07-01

    The Eastern Mediterranean Transient (EMT) occurred in the Aegean Sea from 1988 to 1995 and is the most significant intermediate-to-deep Mediterranean overturning perturbation reported by instrumental records. The EMT was likely caused by accumulation of high salinity waters in the Levantine and enhanced heat loss in the Aegean Sea, coupled with surface water freshening in the Sicily Channel. It is still unknown whether similar transients occurred in the past and, if so, what their forcing processes were. In this study, sediments from the Sicily Channel document surface water freshening (SCFR) at 1910 ± 12, 1812 ± 18, 1725 ± 25 and 1580 ± 30 CE. A regional ocean hindcast links SCFR to enhanced deep-water production and in turn to strengthened Mediterranean thermohaline circulation. Independent evidence collected in the Aegean Sea supports this reconstruction, showing that enhanced bottom water ventilation in the Eastern Mediterranean was associated with each SCFR event. Comparison between the records and multi-decadal atmospheric circulation patterns and climatic external forcings indicates that Mediterranean circulation destabilisation occurs during positive North Atlantic Oscillation (NAO) and negative Atlantic Multidecadal Oscillation (AMO) phases, reduced solar activity and strong tropical volcanic eruptions. They may have recurrently produced favourable deep-water formation conditions, both increasing salinity and reducing temperature on multi-decadal time scales.

  19. Modeling Single-Event Transient Propagation in a SiGe BiCMOS Direct-Conversion Receiver

    NASA Astrophysics Data System (ADS)

    Ildefonso, Adrian; Song, Ickhyun; Tzintzarov, George N.; Fleetwood, Zachary E.; Lourenco, Nelson E.; Wachter, Mason T.; Cressler, John D.

    2017-08-01

    The propagation of single-event transient (SET) signals in a silicon-germanium direct-conversion receiver carrying modulated data is explored. A theoretical analysis of transient propagation, verified by simulation, is presented. A new methodology to characterize and quantify the impact of SETs in communication systems carrying modulated data is proposed. The proposed methodology uses a pulsed radiation source to induce distortions in the signal constellation. The error vector magnitude due to SETs can then be calculated to quantify errors. Two different modulation schemes were simulated: QPSK and 16-QAM. The distortions in the constellation diagram agree with the presented circuit theory. Furthermore, the proposed methodology was applied to evaluate the improvements in the SET response due to a known radiation-hardening-by-design (RHBD) technique, where the common-base device of the low-noise amplifier was operated in inverse mode. The proposed methodology can be a valid technique to determine the most sensitive parts of a system carrying modulated data.

  20. Mediterranean circulation perturbations over the last five centuries: Relevance to past Eastern Mediterranean Transient-type events.

    PubMed

    Incarbona, Alessandro; Martrat, Belen; Mortyn, P Graham; Sprovieri, Mario; Ziveri, Patrizia; Gogou, Alexandra; Jordà, Gabriel; Xoplaki, Elena; Luterbacher, Juerg; Langone, Leonardo; Marino, Gianluca; Rodríguez-Sanz, Laura; Triantaphyllou, Maria; Di Stefano, Enrico; Grimalt, Joan O; Tranchida, Giorgio; Sprovieri, Rodolfo; Mazzola, Salvatore

    2016-07-14

    The Eastern Mediterranean Transient (EMT) occurred in the Aegean Sea from 1988 to 1995 and is the most significant intermediate-to-deep Mediterranean overturning perturbation reported by instrumental records. The EMT was likely caused by accumulation of high salinity waters in the Levantine and enhanced heat loss in the Aegean Sea, coupled with surface water freshening in the Sicily Channel. It is still unknown whether similar transients occurred in the past and, if so, what their forcing processes were. In this study, sediments from the Sicily Channel document surface water freshening (SCFR) at 1910 ± 12, 1812 ± 18, 1725 ± 25 and 1580 ± 30 CE. A regional ocean hindcast links SCFR to enhanced deep-water production and in turn to strengthened Mediterranean thermohaline circulation. Independent evidence collected in the Aegean Sea supports this reconstruction, showing that enhanced bottom water ventilation in the Eastern Mediterranean was associated with each SCFR event. Comparison between the records and multi-decadal atmospheric circulation patterns and climatic external forcings indicates that Mediterranean circulation destabilisation occurs during positive North Atlantic Oscillation (NAO) and negative Atlantic Multidecadal Oscillation (AMO) phases, reduced solar activity and strong tropical volcanic eruptions. They may have recurrently produced favourable deep-water formation conditions, both increasing salinity and reducing temperature on multi-decadal time scales.

  1. Mediterranean circulation perturbations over the last five centuries: Relevance to past Eastern Mediterranean Transient-type events

    PubMed Central

    Incarbona, Alessandro; Martrat, Belen; Mortyn, P. Graham; Sprovieri, Mario; Ziveri, Patrizia; Gogou, Alexandra; Jordà, Gabriel; Xoplaki, Elena; Luterbacher, Juerg; Langone, Leonardo; Marino, Gianluca; Rodríguez-Sanz, Laura; Triantaphyllou, Maria; Di Stefano, Enrico; Grimalt, Joan O.; Tranchida, Giorgio; Sprovieri, Rodolfo; Mazzola, Salvatore

    2016-01-01

    The Eastern Mediterranean Transient (EMT) occurred in the Aegean Sea from 1988 to 1995 and is the most significant intermediate-to-deep Mediterranean overturning perturbation reported by instrumental records. The EMT was likely caused by accumulation of high salinity waters in the Levantine and enhanced heat loss in the Aegean Sea, coupled with surface water freshening in the Sicily Channel. It is still unknown whether similar transients occurred in the past and, if so, what their forcing processes were. In this study, sediments from the Sicily Channel document surface water freshening (SCFR) at 1910 ± 12, 1812 ± 18, 1725 ± 25 and 1580 ± 30 CE. A regional ocean hindcast links SCFR to enhanced deep-water production and in turn to strengthened Mediterranean thermohaline circulation. Independent evidence collected in the Aegean Sea supports this reconstruction, showing that enhanced bottom water ventilation in the Eastern Mediterranean was associated with each SCFR event. Comparison between the records and multi-decadal atmospheric circulation patterns and climatic external forcings indicates that Mediterranean circulation destabilisation occurs during positive North Atlantic Oscillation (NAO) and negative Atlantic Multidecadal Oscillation (AMO) phases, reduced solar activity and strong tropical volcanic eruptions. They may have recurrently produced favourable deep-water formation conditions, both increasing salinity and reducing temperature on multi-decadal time scales. PMID:27412622

  2. Transient Spectroscopic Characterization of the Genesis of a Ruthenium Complex Catalyst Supported on Zeolite Y

    SciTech Connect

    Ogino, Isao; Gates, Bruce C.

    2010-01-12

    A mononuclear ruthenium complex anchored to dealuminated zeolite HY, Ru(acac)(C{sub 2}H{sub 4}){sup 2+} (acac = acetylacetonate, C{sub 5}H{sub 7}O{sup 2}{sup -}), was characterized in flow reactors by transient infrared (IR) spectroscopy and Ru K edge X-ray absorption spectroscopy. The combined results show how the supported complex was converted into a form that catalyzes ethene conversion to butene. The formation of these species resulted from the removal of acac ligands from the ruthenium (as shown by IR and extended X-ray absorption fine structure (EXAFS) spectra) and the simultaneous decrease in the symmetry of the ruthenium complex, with the ruthenium remaining mononuclear and its oxidation state remaining essentially unchanged (as shown by EXAFS and X-ray absorption near-edge structure spectra). The removal of anionic acac ligands from the ruthenium was evidently compensated by the bonding of other anionic ligands, such as hydride from H2 in the feed stream, to form species suggested to be Ru(H)(C{sub 2}H{sub 4}){sub 2}{sup +}, which is coordinatively unsaturated and inferred to react with ethene, leading to the observed formation of butene in a catalytic process.

  3. Ultrafast Transient Absorption Spectroscopy of Polymer-Based Organophotoredox Catalysts Mimicking Transition-Metal Complexes

    NASA Astrophysics Data System (ADS)

    Jamhawi, Abdelqader; Paul, Anam C.; Smith, Justin D.; Handa, Sachin; Liu, Jinjun

    2017-06-01

    Transition-metal complexes of rare earth metals including ruthenium and iridium are most commonly employed as visible-light photocatalysts. Despite their highly important and broad applications, they have many disadvantages including high cost associated with low abundance in earth crust, potential toxicity, requirement of specialized ligands for desired activity, and difficulty in recycling of metal contents as well as associated ligands. Polymer-based organophotoredox catalysts are promising alternatives and possess unique advantages such as easier synthesis from inexpensive starting material, longer excited state life time, broad range of activity, sustainability, and recyclability. In this research talk, time-resolved photoluminescence and femtosecond transient absorption (TA) spectroscopy measurements of three novel polymer-based organophotoredox catalysts will be presented. By our synthetic team, their catalytic activity has been proven in some highly valuable chemical transformations, that otherwise require transition metal complexes. Time-resolved spectroscopic investigations have demonstrated that photoinduced processes in these catalysts are similar to the transition metal complexes. Especially, intramolecular vibrational relaxation, internal conversion, and intersystem crossing from the S1 state to the T1 state all occur on a sub-picosecond timescale. The long lifetime of the T1 state ( 2-3 microsecond) renders these polymers potent oxidizing and reducing agents. A spectroscopic and kinetic model has been developed for global fitting of TA spectra in both the frequency and time domains. Implication of the current ultrafast spectroscopy studies of these novel molecules to their roles in photocatalysis will be discussed.

  4. Plate Coupling and Transient Events Detection from Geodetic Measurements in Nicoya Peninsula, Costa Rica

    NASA Astrophysics Data System (ADS)

    Jiang, Y.; McCaffrey, R.; Wdowinski, S.; Dixon, T.; Protti, M.; Gonzalez, V. M.; Newman, A. V.; Feng, L.

    2011-12-01

    Aseismic tremor and slow slip events (SSE) are known to perturb the stress field at the plate subduction interface. Nicoya Peninsula in northern Costa Rica is located near the Middle America Trench (MAT), where the Cocos plate subducts underneath Caribbean plate. The subducting Cocos plate contains two types of subducting oceanic crust, East Pacific Rise (EPR) in the northern peninsula and Cocos-Nazca Spreading center (CNS) in the southern peninsula. The two crust types differ in subducting speed and orientation, topography, age and heat flow. This unique geological setting provides an opportunity to investigate the kinematics and dynamics of SSE and tremor. In the Nicoya peninsula SSE are found in high b-value regions and occur approximately every 20 months. However, the location and magnitude of SSE are still uncertain due to limited observations. Here we report additional geodetic observations and use a new GPS time-series inversion scheme to investigate simultaneously both SSE and interseismic locking patterns in the study area and their evolution with time. We solve for the steady inter-seismic velocity field and parameters characterizing SSE including slip amount and duration. A preliminary analysis of continuous and campaign GPS data using the time dependent geodetic inversion software TDefnode [McCaffrey 2009] reveals three slow-slipping patches for events in 2003, 2005, 2007 and 2009. Previous inversion analysis of Outerbridge et al. [2010] of the 2007 SSE identified the two of the three patches, a deep on at depth of ~25 km, and a shallower patch at depth of ~7 km. The third patch identified by our inversion at depth of ~15 km is similar in area and location to that reported by Protti et al. [2004] for the 2003 event.

  5. Transient Events in Galactic Cosmic Rays Observed by Voyager-1 beyond the Heliopause

    NASA Astrophysics Data System (ADS)

    Kota, J.; Jokipii, J. R.

    2015-12-01

    Following the passage of Voyager-1 through the Heliopause in August 2012, anomalous cosmic rays essentially disappeared while galactic cosmic rays (GCRs) leveled to a remarkably constant flux. There were two notable exceptions: in March 2013 and May 2014 Voyager-1 experienced small increases of GCRs in the few hundred MeV range. Both events lasted a couple of weeks and were followed by detection of plasma oscillation (Gurnett et al., 2013, 2015). We shall discuss the pitch-angle distribution of GCRs, seen by LECP, and the time profiles of these events. We interpreted the first event as the GCRs remotely sensing a disturbance passing through the magnetic field line of Voyager-1: particles gained energy as they were reflected on the approaching region of stronger magnetic field of the disturbance. Here, we show that energy gain is not restricted to reflected particles, and the effect should be present at all pitch angles in the hemisphere facing the disturbance. The maximum increase of GCR intesity is predicted to occur at the critical reflection angle. The time profile starts with a sharp increase if GCRs are reflected from a sharp shock. However, the disturbance need not be very sharp. For instance, Voyager-1 magnetometer (Burlaga et al., 2013) detected a gradual 5-day increase of the field strength, B, in November 2012. A disturbance with a similar gradual profile would produce a smoother time-profile in the GCR flux at Voyager-1. We shall present numerical simulations and discuss their implications. Burlaga, L.F., et al., Astrophys. J., 778, L3 (2013)Gurnett, D.A., et a;., Science, 341, 1489 (2013)Gurnett, D.A., et al., Astrophys. J., in press (2105)

  6. System level latchup mitigation for single event and transient radiation effects on electronics

    SciTech Connect

    Kimbrough, J.R.; Colella, N.J.

    1994-12-31

    A `blink` technique, analogous to a person blinking at a flash of bright light, is provided for mitigating the effects of single event current latchup and prompt pulse destructive radiation on a micro-electronic circuit. The system includes event detection means, power dump logic means, and energy limiting measures with autonomous recovery. The event detection means includes ionizing radiation pulse detection means for detecting a pulse of ionizing radiation and for providing at an output terminal thereof a detection signal indicative of the detection of a pulse of ionizing radiation or by ion-induced destructive latchup of a semiconductor device. The current sensing means is coupled to the power bus for determining an occurrence of excess current through the power bus caused by ionizing radiation. The power dump means includes power dump logic means having a first input terminal connected to the output terminal of the ionizing radiation pulse detection means and having a second input terminal connected to the output terminal of the current sensing means. The power dump logic means provides an output signal to the input terminal of the means for opening the power bus and the means for shorting the power bus to a ground potential to remove power from the power bus. The energy limiting mean with autonomous recovery includes means for opening the power bus and means for shorting the power bus to a ground potential. The means for opening the power bus and means for shorting the power bus to a ground potential includes a series FET and a shunt FET. The invention provides for self-contained sensing for latchup, first removal of power to protect latched components, and autonomous recovery to enable transparent operation of other system elements.

  7. System level latchup mitigation for single event and transient radiation effects on electronics

    DOEpatents

    Kimbrough, J.R.; Colella, N.J.

    1997-09-30

    A ``blink`` technique, analogous to a person blinking at a flash of bright light, is provided for mitigating the effects of single event current latchup and prompt pulse destructive radiation on a micro-electronic circuit. The system includes event detection circuitry, power dump logic circuitry, and energy limiting measures with autonomous recovery. The event detection circuitry includes ionizing radiation pulse detection means for detecting a pulse of ionizing radiation and for providing at an output terminal thereof a detection signal indicative of the detection of a pulse of ionizing radiation. The current sensing circuitry is coupled to the power bus for determining an occurrence of excess current through the power bus caused by ionizing radiation or by ion-induced destructive latchup of a semiconductor device. The power dump circuitry includes power dump logic circuitry having a first input terminal connected to the output terminal of the ionizing radiation pulse detection circuitry and having a second input terminal connected to the output terminal of the current sensing circuitry. The power dump logic circuitry provides an output signal to the input terminal of the circuitry for opening the power bus and the circuitry for shorting the power bus to a ground potential to remove power from the power bus. The energy limiting circuitry with autonomous recovery includes circuitry for opening the power bus and circuitry for shorting the power bus to a ground potential. The circuitry for opening the power bus and circuitry for shorting the power bus to a ground potential includes a series FET and a shunt FET. The invention provides for self-contained sensing for latchup, first removal of power to protect latched components, and autonomous recovery to enable transparent operation of other system elements. 18 figs.

  8. System level latchup mitigation for single event and transient radiation effects on electronics

    DOEpatents

    Kimbrough, Joseph Robert; Colella, Nicholas John

    1997-01-01

    A "blink" technique, analogous to a person blinking at a flash of bright light, is provided for mitigating the effects of single event current latchup and prompt pulse destructive radiation on a micro-electronic circuit. The system includes event detection circuitry, power dump logic circuitry, and energy limiting measures with autonomous recovery. The event detection circuitry includes ionizing radiation pulse detection means for detecting a pulse of ionizing radiation and for providing at an output terminal thereof a detection signal indicative of the detection of a pulse of ionizing radiation. The current sensing circuitry is coupled to the power bus for determining an occurrence of excess current through the power bus caused by ionizing radiation or by ion-induced destructive latchup of a semiconductor device. The power dump circuitry includes power dump logic circuitry having a first input terminal connected to the output terminal of the ionizing radiation pulse detection circuitry and having a second input terminal connected to the output terminal of the current sensing circuitry. The power dump logic circuitry provides an output signal to the input terminal of the circuitry for opening the power bus and the circuitry for shorting the power bus to a ground potential to remove power from the power bus. The energy limiting circuitry with autonomous recovery includes circuitry for opening the power bus and circuitry for shorting the power bus to a ground potential. The circuitry for opening the power bus and circuitry for shorting the power bus to a ground potential includes a series FET and a shunt FET. The invention provides for self-contained sensing for latchup, first removal of power to protect latched components, and autonomous recovery to enable transparent operation of other system elements.

  9. The Evolution and Motion of Transient Events in The Solar Wind-Magnetosphere Interaction

    NASA Astrophysics Data System (ADS)

    Collado-Vega, Yaireska Marie

    Instabilities in the solar wind-magnetosphere interaction govern the entry of solar wind particles into the Earth's magnetosphere. These particles could ultimately be responsible for serious damage to our current technological systems. I use simulations and observations to investigate two kinds of instabilities that occur during unsteady interaction, magnetopause vortices and bursty reconnection resulting in flux transfer events (FTEs). For the magnetopause vortices analysis, magnetohydrodynamic (MHD) simulations were generated. Two cases were run, one for a nominal speed solar wind (360 km/s) and another for a high speed solar wind (700 km/s). Both cases had an abrupt change in the interplanetary magnetic field (IMF) orientation; 15 minutes being southward, -5 nT, and then turning northward, +5 nT, for two hours. No other parameter was changed in these runs. Using an IDL-based tool, I visualized the 2D and 3D nature of the vortices and compared my results with those obtained previously by Collado-Vega et al. (2007) who studied vortices using simulated MHD data initiated by real solar wind conditions. The characteristics of the vortices formed under dynamic solar wind conditions are consistent with vortices driven by surface waves on the magnetopause, like the Kelvin-Helmholtz (KH) instability. However, the majority of those developed under steady solar wind conditions suggest otherwise, especially the ones that developed on the dayside which are believed to be formed by the convection pattern created by high latitude reconnection. For the study of FTEs, I focus on Cluster satellite magnetopause encounters. The Cluster satellites orbit in a tetrahedral formation in near-polar orbits. I identified FTEs in Cluster observations from 2002 to 2003, and a total of 109 events were counted in the data set. A comparison of the analytical and global MHD simulation results indicates that most of the events form by component reconnection along a tilted subsolar reconnection

  10. NREM sleep transient events in fronto-temporal dementia: beyond sleep stage architecture.

    PubMed

    Maestri, Michelangelo; Carnicelli, Luca; Economou, Nicholas-Tiberio; Bonakis, Anastasios; Paparrigopoulos, Thomas; Papageorgiou, Sokratis T; Giorgi, Filippo Sean; Di Coscio, Elisa; Tognoni, Gloria; Ferri, Raffaele; Bonuccelli, Ubaldo; Bonanni, Enrica

    2015-01-01

    Frontotemporal dementia (FTD) is increasingly becoming recognized as a major cause of early onset (<65 years) neurodegenerative dementia. Although sleep disorders significantly impair patients' and caregivers' quality of life in neurodegenerative diseases, polysomnographic data in FTD patients are scarce in literature. Aim of our study was to investigate sleep microstructure in FTD, by means of Cyclic Alternating Pattern (CAP), in a group of ten behavioral variant FTD patients (6 M, 4 F; mean age 61.2±7.3 years; disease duration: 1.4±0.7 years) and to compare them with cognitively intact healthy elderly. Sleep in FTD patients was altered at different levels, involving not only the conventional sleep stage architecture parameters (total sleep time, single stage percentage, NREM/REM cycle organization), but also microstructure. FTD subjects showed CAP disruption with decreased slow wave activity related phases (A1 index, n/h:14.5±6.8 vs 38.8±6.6; p<.001) and increased arousal-related fast CAP components (A2 index 22.9±8.2 vs 11.6±3.7; p=.006; A3 index 41.9±20.7 vs 13.0±6.5; p=.002). Several correlations between sleep variables and neuropsychological tests were found. Sleep impairment in FTD may be specifically related to the specific frontal lobe involvement in the neurodegenerative process. The pattern of alterations seems somewhat peculiar, probably due to the anatomical distribution of the neurodegenerative process with a major impact on frontal lobe generated sleep transients, and a substantial sparing of phenomena related to the posterior cortex.

  11. Hospital-Based Prospective Registration of Acute Transient Ischemic Attack and Noncerebrovascular Events in Korea.

    PubMed

    Chang, Jun Young; Kim, Do Houng; Chung, Jin-Heon; Yum, Kyu Sun; Hong, Jeong-Ho; Han, Moon-Ku

    2015-08-01

    There have been no prospective studies on the clinical features, etiologies, and outcome of transient ischemic attack (TIA) in Korea. The aim of this study was to identify variables that can discriminate TIA from TIA mimics. Also we evaluated the characteristic of TIA patients according to the presence of diffusion-weighted imaging (DWI) lesion. Patients were categorized into TIA and TIA mimics according to the result of an initial workup. TIA patients were divided according to the presence of DWI lesions. Baseline demographics, risk factors, laboratory results, initial blood pressure, imaging findings, recurrence rate of TIA or stroke at 3 months, and initial neurologic manifestations were prospectively collected and compared. We evaluated a total of 252 patients (212 with TIA and 40 with TIA mimics). Steno-occlusion of the relevant artery (odds ratio [OR], 22.39; 95% confidence interval [CI], 2.03-246.73) and cardioembolic risk (OR, 32.15; 95% CI, 1.12-922.97) were significantly associated with TIA. Amnesia (OR, .001; 95% CI, .00-.05) and consciousness disturbance (OR, .003; 95% CI, .00-.06) favored TIA mimics. Perfusion defect (OR, 5.56; 95% CI, 2.90-10.68) and cardioembolic risk (OR, 2.68; 95% CI, 1.14-6.32) were significantly associated with DWI lesion. Recurrence did not significantly differ according to the presence of a lesion on DWI (positive, 4.9%; negative, 7.8%; P = .41). Steno-occlusive disease and cardioembolic risk were independently associated with TIA. Perfusion defect and cardioembolic risk predicted positive DWI lesion. The value of various imaging modalities for predicting TIA etiology needs further evaluation. Copyright © 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved.

  12. Mini-MegaTORTORA Wide-Field Monitoring System with Subsecond Temporal Resolution: Observation of Transient Events

    NASA Astrophysics Data System (ADS)

    Karpov, S.; Beskin, G.; Biryukov, A.; Bondar, S.; Ivanov, E.; Katkova, E.; Orekhova, N.; Perkov, A.; Sasyuk, V.

    2017-06-01

    Here we present the summary of first years of operation and the first results of a novel 9-channel wide-field optical monitoring system with sub-second temporal resolution, Mini-MegaTORTORA (MMT-9), which is in operation now at Special Astrophysical Observatory on Russian Caucasus. The system is able to observe the sky simultaneously in either wide (˜900 square degrees) or narrow (˜100 square degrees) fields of view, either in clear light or with any combination of color (Johnson-Cousins B, V or R) and polarimetric filters installed, with exposure times ranging from 0.1 s to hundreds of seconds.The real-time system data analysis pipeline performs automatic detection of rapid transient events, both near-Earth and extragalactic. The objects routinely detected by MMT include faint meteors and artificial satellites.

  13. Observations of transient events with Mini-MegaTORTORA wide-field monitoring system with sub-second temporal resolution

    NASA Astrophysics Data System (ADS)

    Karpov, S.; Beskin, G.; Biryukov, A.; Bondar, S.; Ivanov, E.; Katkova, E.; Orekhova, N.; Perkov, A.; Sasyuk, V.

    2017-07-01

    Here we present the summary of first years of operation and the first results of a novel 9-channel wide-field optical monitoring system with sub-second temporal resolution, Mini-MegaTORTORA (MMT-9), which is in operation now at Special Astrophysical Observatory on Russian Caucasus. The system is able to observe the sky simultaneously in either wide (900 square degrees) or narrow (100 square degrees) fields of view, either in clear light or with any combination of color (Johnson-Cousins B, V or R) and polarimetric filters installed, with exposure times ranging from 0.1 s to hundreds of seconds.The real-time system data analysis pipeline performs automatic detection of rapid transient events, both near-Earth and extragalactic. The objects routinely detected by MMT also include faint meteors and artificial satellites.

  14. Mini-MegaTORTORA wide-field monitoring system with sub-second temporal resolution: observation of transient events

    NASA Astrophysics Data System (ADS)

    Karpov, S.; Beskin, G.; Biryukov, A.; Bondar, S.; Ivanov, E.; Katkova, E.; Perkov, A.; Sasyuk, V.

    2016-06-01

    Here we present a summary of first years of operation and first results of a novel 9-channel wide-field optical monitoring system with sub-second temporal resolution, Mini-MegaTORTORA (MMT-9), which is in operation now at Special Astrophysical Observatory on Russian Caucasus. The system is able to observe the sky simultaneously in either wide (~900 square degrees) or narrow (~100 square degrees) fields of view, either in clear light or with any combination of color (Johnson-Cousins B, V or R) and polarimetric filters installed, with exposure times ranging from 0.1 s to hundreds of seconds. The real-time system data analysis pipeline performs automatic detection of rapid transient events, both near-Earth and extragalactic. The objects routinely detected by MMT include faint meteors and artificial satellites. The pipeline for a longer time scales variability analysis is still in development.

  15. The ultraviolet-bright, slowly declining transient PS1-11af as a partial tidal disruption event

    SciTech Connect

    Chornock, R.; Berger, E.; Zauderer, B. A.; Kamble, A.; Soderberg, A. M.; Czekala, I.; Dittmann, J.; Drout, M.; Foley, R. J.; Fong, W.; Kirshner, R. P.; Lunnan, R.; Marion, G. H.; Narayan, G.; Gezari, S.; Rest, A.; Riess, A. G.; Chomiuk, L.; Huber, M. E.; Lawrence, A.; and others

    2014-01-01

    We present the Pan-STARRS1 discovery of the long-lived and blue transient PS1-11af, which was also detected by Galaxy Evolution Explorer with coordinated observations in the near-ultraviolet (NUV) band. PS1-11af is associated with the nucleus of an early type galaxy at redshift z = 0.4046 that exhibits no evidence for star formation or active galactic nucleus activity. Four epochs of spectroscopy reveal a pair of transient broad absorption features in the UV on otherwise featureless spectra. Despite the superficial similarity of these features to P-Cygni absorptions of supernovae (SNe), we conclude that PS1-11af is not consistent with the properties of known types of SNe. Blackbody fits to the spectral energy distribution are inconsistent with the cooling, expanding ejecta of a SN, and the velocities of the absorption features are too high to represent material in homologous expansion near a SN photosphere. However, the constant blue colors and slow evolution of the luminosity are similar to previous optically selected tidal disruption events (TDEs). The shape of the optical light curve is consistent with models for TDEs, but the minimum accreted mass necessary to power the observed luminosity is only ∼0.002 M {sub ☉}, which points to a partial disruption model. A full disruption model predicts higher bolometric luminosities, which would require most of the radiation to be emitted in a separate component at high energies where we lack observations. In addition, the observed temperature is lower than that predicted by pure accretion disk models for TDEs and requires reprocessing to a constant, lower temperature. Three deep non-detections in the radio with the Very Large Array over the first two years after the event set strict limits on the production of any relativistic outflow comparable to Swift J1644+57, even if off-axis.

  16. A transient heating event in the history of a highlands troctolite from Apollo 12 soil 12033

    NASA Technical Reports Server (NTRS)

    Marvin, U. B.; Walker, D.

    1985-01-01

    A 2-mm particle, consisting of a troctolite clast attached to a small amount of glassy soil breccia, was found in a thin section of grains from Apollo 12 sample 12033,66. A description is given of the evolutionary history of the troctolite, taking into account the unique texture. It appears that the particle was broken from its parent rock and projected to Oceanus Procellarum from a source area in the highlands. Before, during, or after the flight, the troctolite was welded to a soil breccia by a minor amount of melting along the contact. It is argued that two separate heating events may be involved. The hypothesis is considered that the partial remelting and quenching of the troctolite took place very rapidly. Attention is given to melting experiments which test and confirm this hypothesis.

  17. A transient heating event in the history of a highlands troctolite from Apollo 12 soil 12033

    NASA Astrophysics Data System (ADS)

    Marvin, U. B.; Walker, D.

    1985-02-01

    A 2-mm particle, consisting of a troctolite clast attached to a small amount of glassy soil breccia, was found in a thin section of grains from Apollo 12 sample 12033,66. A description is given of the evolutionary history of the troctolite, taking into account the unique texture. It appears that the particle was broken from its parent rock and projected to Oceanus Procellarum from a source area in the highlands. Before, during, or after the flight, the troctolite was welded to a soil breccia by a minor amount of melting along the contact. It is argued that two separate heating events may be involved. The hypothesis is considered that the partial remelting and quenching of the troctolite took place very rapidly. Attention is given to melting experiments which test and confirm this hypothesis.

  18. Transient Cosmic-ray Events beyond the Heliopause: Interpreting Voyager-1 Observations

    NASA Astrophysics Data System (ADS)

    Kóta, J.; Jokipii, J. R.

    2017-04-01

    In 2013 March and 2014 May, Voyager-1 (V1) experienced small but significant increases in the flux of galactic cosmic rays (GCRs) in the hundred MeV/n range. Additionally, V1 also saw episodic depletion of GCR flux around perpendicular pitch angles. We discuss the pitch-angle distribution and the time profiles of these events. In a previous paper, we interpreted the 2013 “bump” as the GCRs remotely sensing a shock that reached the magnetic field line passing through V1: particles gained energy as they were reflected on the approaching region of the stronger magnetic field of the disturbance. Here, we point out that energy gain is not restricted to reflected particles—GCRs passing through the disturbance also gain energy. The effect should be present in a broad range of pitch angles with the maximum increase of GCR intensity predicted to occur at the critical reflection angle. In this paper, the shock is not step-like, but a gradual increase of the magnetic field strength, B, taking a few days, in agreement with V1 measurements. This smoothens the profile of the predicted bump in the GCR flux. We also address the linear episodic decreases seen around perpendicular pitch angles. These events are interpreted in terms of adiabatic cooling behind the shock due to the slow weakening of B. We present simple numerical model calculations and find that a gradual shock followed by a slow decrease of B, as observed, may account for both the episodic increases and the anisotropic depletion of GCR fluxes.

  19. On remote sensing of transient luminous events' parent lightning discharges by ELF/VLF wave measurements on board a satellite

    NASA Astrophysics Data System (ADS)

    Lefeuvre, F.; Marshall, R.; PinçOn, J. L.; Inan, U. S.; Lagoutte, D.; Parrot, M.; Berthelier, J. J.

    2009-09-01

    First recordings of satellite ELF/VLF waveform data associated with transient luminous event (TLE) observations are reported from the summer 2005 campaign coordinated by Stanford University and Laboratoire de Physique et Chimie de l'Environnement et de l'Espace (LPCE). TLEs are optically observed from the U.S. Langmuir Laboratory, while ELF/VLF waveform data are simultaneously recorded on board the Centre National d'Etudes Spatiales microsatellite DEMETER and on the ground at Langmuir. Analyses of ELF/VLF measurements associated with sprite events observed on 28 July 2005 and 3 August 2005 are presented. Conditions to trace back the wave emissions from the satellite to the source region of the parent lightning discharge are discussed. The main results concern: (1) the identification from a low Earth orbit satellite of the 0+ whistler signatures of the TLE causative lightning; (2) the identification of the propagation characteristics of proton whistlers triggered by the 0+ whistlers of the causative lightning, and the potential use of those characteristics; (3) recognition of the difficulty to observe sprite-produced ELF bursts in the presence of proton-whistlers; (4) the use of geographical displays of the average power received by the DEMETER electric field antennas over the U.S. Navy transmitter North West Cape (NWC) located in Western Australia to evaluate VLF transmission cones which explain the presence (28 July events) or the absence (3 August events) of propagation links between sferics observed at ground and 0+ whistlers observed on DEMETER; and (5) owing to electron-collisions, an optimum transfer of energy from the atmosphere to the ionosphere for waves with k vectors antiparallel, or quasi-antiparallel, to Earth's magnetic field direction.

  20. Complex Dynamic Scene Perception: Effects of Attentional Set on Perceiving Single and Multiple Event Types

    ERIC Educational Resources Information Center

    Sanocki, Thomas; Sulman, Noah

    2013-01-01

    Three experiments measured the efficiency of monitoring complex scenes composed of changing objects, or events. All events lasted about 4 s, but in a given block of trials, could be of a single type (single task) or of multiple types (multitask, with a total of four event types). Overall accuracy of detecting target events amid distractors was…

  1. Rapid processing of chemosensor transients in a neuromorphic implementation of the insect macroglomerular complex

    PubMed Central

    Pearce, Timothy C.; Karout, Salah; Rácz, Zoltán; Capurro, Alberto; Gardner, Julian W.; Cole, Marina

    2012-01-01

    We present a biologically-constrained neuromorphic spiking model of the insect antennal lobe macroglomerular complex that encodes concentration ratios of chemical components existing within a blend, implemented using a set of programmable logic neuronal modeling cores. Depending upon the level of inhibition and symmetry in its inhibitory connections, the model exhibits two dynamical regimes: fixed point attractor (winner-takes-all type), and limit cycle attractor (winnerless competition type) dynamics. We show that, when driven by chemosensor input in real-time, the dynamical trajectories of the model's projection neuron population activity accurately encode the concentration ratios of binary odor mixtures in both dynamical regimes. By deploying spike timing-dependent plasticity in a subset of the synapses in the model, we demonstrate that a Hebbian-like associative learning rule is able to organize weights into a stable configuration after exposure to a randomized training set comprising a variety of input ratios. Examining the resulting local interneuron weights in the model shows that each inhibitory neuron competes to represent possible ratios across the population, forming a ratiometric representation via mutual inhibition. After training the resulting dynamical trajectories of the projection neuron population activity show amplification and better separation in their response to inputs of different ratios. Finally, we demonstrate that by using limit cycle attractor dynamics, it is possible to recover and classify blend ratio information from the early transient phases of chemosensor responses in real-time more rapidly and accurately compared to a nearest-neighbor classifier applied to the normalized chemosensor data. Our results demonstrate the potential of biologically-constrained neuromorphic spiking models in achieving rapid and efficient classification of early phase chemosensor array transients with execution times well beyond biological timescales. PMID

  2. Sex Differences in Infants' Ability to Represent Complex Event Sequences

    ERIC Educational Resources Information Center

    Schweinle, Amy; Wilcox, Teresa

    2004-01-01

    Prior research suggests that when very simple event sequences are used, 4.5-month-olds demonstrate the ability to individuate objects based on the continuity or disruption of their speed of motion (Wilcox & Schweinle, 2003). However, infants demonstrate their ability to individuate objects in an event-monitoring task (i.e., infants must keep track…

  3. On extreme transient events from rotating black holes and their gravitational wave emission

    NASA Astrophysics Data System (ADS)

    van Putten, Maurice H. P. M.; Della Valle, Massimo

    2017-01-01

    The super-luminous object ASASSN-15lh (SN2015L) is an extreme event with a total energy Erad ≃ 1.1 × 1052 erg in blackbody radiation on par with its kinetic energy Ek in ejecta and a late time plateau in the UV, which defies a nuclear origin. It likely presents a new explosion mechanism for hydrogen-deprived supernovae. With no radio emission and no H-rich environment, we propose to identify Erad with dissipation of a baryon-poor outflow in the optically thick remnant stellar envelope produced by a central engine. By negligible time-scales of light crossing and radiative cooling of the envelope, SN2015L's light curve closely tracks the evolution of this engine. We here model its light curve by the evolution of black hole spin during angular momentum loss in Alvén waves to matter at the Inner Most Stable Circular Orbit (ISCO). The duration is determined by σ = MT/M of the torus mass MT around the black hole of mass M: σ ˜ 10-7 and σ ˜ 10-2 for SN2015L and, respectively, a long GRB. The observed electromagnetic radiation herein represents a minor output of the rotational energy Erot of the black hole, while most is radiated unseen in gravitational radiation. This model explains the high-mass slow-spin binary progenitor of GWB150914, as the remnant of two CC-SNe in an intra-day binary of two massive stars. This model rigorously predicts a change in magnitude Δm ≃ 1.15 in the light curve post-peak, in agreement with the light curve of SN2015L with no fine-tuning.

  4. Extreme events in multilayer, interdependent complex networks and control

    PubMed Central

    Chen, Yu-Zhong; Huang, Zi-Gang; Zhang, Hai-Feng; Eisenberg, Daniel; Seager, Thomas P.; Lai, Ying-Cheng

    2015-01-01

    We investigate the emergence of extreme events in interdependent networks. We introduce an inter-layer traffic resource competing mechanism to account for the limited capacity associated with distinct network layers. A striking finding is that, when the number of network layers and/or the overlap among the layers are increased, extreme events can emerge in a cascading manner on a global scale. Asymptotically, there are two stable absorption states: a state free of extreme events and a state of full of extreme events, and the transition between them is abrupt. Our results indicate that internal interactions in the multiplex system can yield qualitatively distinct phenomena associated with extreme events that do not occur for independent network layers. An implication is that, e.g., public resource competitions among different service providers can lead to a higher resource requirement than naively expected. We derive an analytical theory to understand the emergence of global-scale extreme events based on the concept of effective betweenness. We also articulate a cost-effective control scheme through increasing the capacity of very few hubs to suppress the cascading process of extreme events so as to protect the entire multi-layer infrastructure against global-scale breakdown. PMID:26612009

  5. Extreme events in multilayer, interdependent complex networks and control

    NASA Astrophysics Data System (ADS)

    Chen, Yu-Zhong; Huang, Zi-Gang; Zhang, Hai-Feng; Eisenberg, Daniel; Seager, Thomas P.; Lai, Ying-Cheng

    2015-11-01

    We investigate the emergence of extreme events in interdependent networks. We introduce an inter-layer traffic resource competing mechanism to account for the limited capacity associated with distinct network layers. A striking finding is that, when the number of network layers and/or the overlap among the layers are increased, extreme events can emerge in a cascading manner on a global scale. Asymptotically, there are two stable absorption states: a state free of extreme events and a state of full of extreme events, and the transition between them is abrupt. Our results indicate that internal interactions in the multiplex system can yield qualitatively distinct phenomena associated with extreme events that do not occur for independent network layers. An implication is that, e.g., public resource competitions among different service providers can lead to a higher resource requirement than naively expected. We derive an analytical theory to understand the emergence of global-scale extreme events based on the concept of effective betweenness. We also articulate a cost-effective control scheme through increasing the capacity of very few hubs to suppress the cascading process of extreme events so as to protect the entire multi-layer infrastructure against global-scale breakdown.

  6. ARAD proteins associated with pectic Arabinan biosynthesis form complexes when transiently overexpressed in planta.

    PubMed

    Harholt, Jesper; Jensen, Jacob Krüger; Verhertbruggen, Yves; Søgaard, Casper; Bernard, Sophie; Nafisi, Majse; Poulsen, Christian Peter; Geshi, Naomi; Sakuragi, Yumiko; Driouich, Azeddine; Knox, J Paul; Scheller, Henrik Vibe

    2012-07-01

    Glycosyltransferase complexes are known to be involved in plant cell wall biosynthesis, as for example in cellulose. It is not known to what extent such complexes are involved in biosynthesis of pectin as well. To address this question, work was initiated on ARAD1 (ARABINAN DEFICIENT 1) and its close homolog ARAD2 of glycosyltransferase family GT47. Using bimolecular fluorescence complementation, Förster resonance energy transfer and non-reducing gel electrophoresis, we show that ARAD1 and ARAD2 are localized in the same Golgi compartment and form homo-and heterodimeric intermolecular dimers when expressed transiently in Nicotiana benthamiana. Biochemical analysis of arad2 cell wall or fractions hereof showed no difference in the monosaccharide composition, when compared with wild type. The double mutant arad1 arad2 had an arad1 cell wall phenotype and overexpression of ARAD2 did not complement the arad1 phenotype, indicating that ARAD1 and ARAD2 are not redundant enzymes. To investigate the cell wall structure of the mutants in detail, immunohistochemical analyses were carried out on arad1, arad2 and arad1 arad2 using the arabinan-specific monoclonal antibody LM13. In roots, the labeling pattern of arad2 was distinct from both that of wild type, arad1 and arad1 arad2. Likewise, in epidermal cell walls of inflorescence stems, LM13 binding differed between arad2 and WILD TYPE, arad1 or arad1 arad2. Altogether, these data show that ARAD2 is associated with arabinan biosynthesis, not redundant with ARAD1, and that the two glycosyltransferases may function in complexes held together by disulfide bridges.

  7. A direct comparison of selectin-mediated transient, adhesive events using high temporal resolution.

    PubMed Central

    Smith, M J; Berg, E L; Lawrence, M B

    1999-01-01

    Leukocyte capture and rolling on the vascular endothelium is mediated principally by the selectin family of cell adhesion receptors. In a parallel plate flow chamber, neutrophil rolling on purified selectins or a selectin-ligand substrate was resolved by high speed videomicroscopy as a series of ratchet-like steps with a characteristic time constant (Kaplanski, G., C. Farnarier, O. Tissot, A. Pierres, A.-M. Benoliel, M. C. Alessi, S. Kaplanski, and P. Bongrand. 1993. Biophys. J. 64:1922-1933; Alon, R., D. A. Hammer, and T. A. Springer. 1995. Nature (Lond.). 374:539-542). Under shear, neutrophil arrests due to bond formation events were as brief as 4 ms. Pause time distributions for neutrophils tethering on P-, E-, L-selectin, or peripheral node addressin (PNAd) were compared at estimated single bond forces ranging from 37 to 250 pN. Distributions of selectin mediated pause times were fit to a first order exponential, resulting in a molecular dissociation constant (k(off)) for the respective selectin as a function of force. At estimated single bond forces of 125 pN and below, all three selectin dissociation constants fit the Bell and Hookean spring models of force-driven bond breakage equivalently. Unstressed k(off) values based on the Bell model were 2.4, 2.6, 2.8, 3.8 s(-1) for P-selectin, E-selectin, L-selectin, and PNAd, respectively. Bond separation distances (reactive compliance) were 0.39, 0.18, 1.11, 0.59 A for P-selectin, E-selectin, L-selectin, and PNAd, respectively. Dissociation constants for L-selectin and P-selectin at single bond forces above 125 pN were considerably lower than either Bell or Hookean spring model predictions, suggesting the existence of two regimes of reactive compliance. Additionally, interactions between L-selectin and its leukocyte ligand(s) were more labile in the presence of flow than the L-selectin endothelial ligand, PNAd, suggesting that L-selectin ligands may have different molecular and mechanical properties. Both types of L

  8. Analyzing a steady-state phenomenon using an ensemble of sequential transient events: A proof of concept on photocurrent of bacteriorhodopsin upon continuous photoexcitation

    SciTech Connect

    Hung, Chang-Wei; Chu, Li-Kang; Ho, Ching-Hwa

    2014-10-14

    The proton pump activity of bacteriorhodopsin in aqueous solution upon excitation with modulated continuous light was monitored electrochemically and analyzed by superimposing a series of transient proton translocation events Hᵢ⁺(t). An evolution function f(t)=(he{sup –lt}+k)/(h+k) , including a decay and a stationary offset, was introduced to weight the contribution of the individual transient events evolving with time in the envelope of the steady-state event. The evolution of the total proton concentration can be treated as an ensemble of weighted sequential transient events, H{sub total}⁺(t)=Σ{{sub i=0}sup n}Hᵢ⁺(t)∙f(t), and the temporal profile of the photocurrent is derived by differentiating the proton concentration with respect to time, (table) . The temporal profiles of the bacteriorhodopsin photocurrent in pH range of 6.3–8.1 were analyzed using a well-defined kinetics model and restricted mathematical formulization, and fitted temporal behaviors agreed with the observations. This successful proof-of-concept study on analyzing a steady-state phenomenon using an ensemble of sequential transient events can be generalized to quantify other phenomena upon continuous stimulation, such as estimation of the light-driven ion pump activities of the photosynthetic proteins upon illumination.

  9. Analysis of single event transient pulse-width in 65 nm commercial radiation-hardened logic cell

    NASA Astrophysics Data System (ADS)

    Li, Haisong; Wu, Longsheng; Yang, Bo; Jiang, Yihu

    2017-08-01

    With the critical charge reduced to generate a single event effect (SEE) and high working frequency for a nanometer integrated circuit, the single event effect (SET) becomes increasingly serious for high performance SOC and DSP chips. To analyze the radiation-hardened method of SET for the nanometer integrated circuit, the n+ guard ring and p+ guard ring have been adopted in the layout for a 65 nm commercial radiation-hardened standard cell library. The weakest driving capacity inverter cell was used to evaluate the single event transient (SET) pulse-width distribution. We employed a dual-lane measurement circuit to get more accurate SET’s pulse-width. Six kinds of ions, which provide LETs of 12.5, 22.5, 32.5, 42, 63, and 79.5 {MeV}\\cdot {{cm}}2/{mg}, respectively, have been utilized to irradiate the SET test circuit in the Beijing Tandem Accelerator Nuclear Physics National Laboratory. The testing results reveal that the pulse-width of most SETs is shorter than 400 ps in the range of LETeff from 12.5 {MeV}\\cdot {{cm}}2/{mg} to 79.5 {MeV}\\cdot {{cm}}2/{mg} and the pulse-width presents saturation tendency when the effective linear energy transfer (LETeff) value is larger than 40 {MeV}\\cdot {{cm}}2/{mg}. The test results also show that the hardened commercial standard cell’s pulse-width concentrates on 33 to 264 ps, which decreases by 40% compared to the pulse-width of the 65 nm commercial unhardened standard cell.

  10. The frontopolar cortex mediates event knowledge complexity: a parametric functional MRI study.

    PubMed

    Krueger, Frank; Spampinato, Maria Vittoria; Barbey, Aron K; Huey, Edward D; Morland, Thomas; Grafman, Jordan

    2009-08-05

    Event knowledge is organized on the basis of goals that enable the selection of specific event sequences to organize everyday life activities. Although the medial prefrontal cortex represents event knowledge, little is known about its role in mediating event knowledge complexity. We used functional MRI to investigate the patterns of brain activation while healthy volunteers were engaged in the task of evaluating the complexity (i.e. numbers of events) of daily life activities selected on the basis of normative data. Within a left frontoparietal network, we isolated the medial frontopolar cortex as the only region that showed a linear relationship between changes in the blood oxygen level-dependent signal and changes in event knowledge complexity. Our results specify the importance of the medial frontopolar cortex in subserving event knowledge that is required to build and execute complex behavior.

  11. Short relaxation times but long transient times in both simple and complex reaction networks

    PubMed Central

    Henry, Adrien; Martin, Olivier C.

    2016-01-01

    When relaxation towards an equilibrium or steady state is exponential at large times, one usually considers that the associated relaxation time τ, i.e. the inverse of the decay rate, is the longest characteristic time in the system. However, that need not be true, other times such as the lifetime of an infinitesimal perturbation can be much longer. In the present work, we demonstrate that this paradoxical property can arise even in quite simple systems such as a linear chain of reactions obeying mass action (MA) kinetics. By mathematical analysis of simple reaction networks, we pin-point the reason why the standard relaxation time does not provide relevant information on the potentially long transient times of typical infinitesimal perturbations. Overall, we consider four characteristic times and study their behaviour in both simple linear chains and in more complex reaction networks taken from the publicly available database ‘Biomodels’. In all these systems, whether involving MA rates, Michaelis–Menten reversible kinetics, or phenomenological laws for reaction rates, we find that the characteristic times corresponding to lifetimes of tracers and of concentration perturbations can be significantly longer than τ. PMID:27411726

  12. Simulation of the infrared signature of transient luminous events in the middle atmosphere for a limb line of sight

    NASA Astrophysics Data System (ADS)

    Romand, Frédéric; Croizé, Laurence; Payan, Sébastien; Huret, Nathalie

    2016-04-01

    Transient Luminous Events (TLE) are electrical and optical events which occurs above thunderstorms. Visual signatures are reported since the beginning of the 20th century but the first picture is accidentally recorded from a television camera in 1989. Their occurrence is closely linked with the lightning activity below thunderstorms. TLEs are observed from the base of the stratosphere to the thermosphere (15 - 110 km). They are a very brief phenomenon which lasts from 1 to 300 milliseconds. At a worldwide scale, four TLEs occur each minute. The energy deposition, about some tenth of megajoules, is able to ionize, dissociate and excite the molecules of the atmosphere. Atmospheric discharges in the troposphere are important sources of NO and NO2. TLEs might have the same effects at higher altitudes, in the stratosphere. NOx then can affect the concentration of O3 and OH. Consequently, TLEs could be locally important contributors to the chemical budget of the middle atmosphere. The perturbation of the atmospheric chemistry induced by TLEs has the consequence to locally modify the radiations in the infrared during the minutes following the event. The interest of studying the infrared signature of a TLE is twofold. For the atmospheric sciences it allows to link the perturbed composition to the resulting infrared spectrum. Then, some Defense systems like detection and guiding devices are equipped with airborne infrared sensors so that the TLE infrared signature might disturb them. We want to obtain a quantitative and kinetic evaluation of the infrared signature of the atmosphere locally perturbed by a TLE. In order to do so we must model three phenomena. 1) The plasma/chemistry coupling, which describes how the different energetic levels of atmospheric molecules are populated by the energetic deposition of the TLE. This step lasts the time of the lightning itself. 2) The chemical kinetics which describes how these populations will evolve in the following minutes. 3) The

  13. Transient Protein-Protein Interaction of the SH3-Peptide Complex via Closely Located Multiple Binding Sites

    PubMed Central

    Hahn, Seungsoo; Kim, Dongsup

    2012-01-01

    Protein-protein interactions play an essential role in cellular processes. Certain proteins form stable complexes with their partner proteins, whereas others function by forming transient complexes. The conventional protein-protein interaction model describes an interaction between two proteins under the assumption that a protein binds to its partner protein through a single binding site. In this study, we improved the conventional interaction model by developing a Multiple-Site (MS) model in which a protein binds to its partner protein through closely located multiple binding sites on a surface of the partner protein by transiently docking at each binding site with individual binding free energies. To test this model, we used the protein-protein interaction mediated by Src homology 3 (SH3) domains. SH3 domains recognize their partners via a weak, transient interaction and are therefore promiscuous in nature. Because the MS model requires large amounts of data compared with the conventional interaction model, we used experimental data from the positionally addressable syntheses of peptides on cellulose membranes (SPOT-synthesis) technique. From the analysis of the experimental data, individual binding free energies for each binding site of peptides were extracted. A comparison of the individual binding free energies from the analysis with those from atomistic force fields gave a correlation coefficient of 0.66. Furthermore, application of the MS model to 10 SH3 domains lowers the prediction error by up to 9% compared with the conventional interaction model. This improvement in prediction originates from a more realistic description of complex formation than the conventional interaction model. The results suggested that, in many cases, SH3 domains increased the protein complex population through multiple binding sites of their partner proteins. Our study indicates that the consideration of general complex formation is important for the accurate description of

  14. Hydraulic Transients in the Long Diversion-Type Hydropower Station with a Complex Differential Surge Tank

    PubMed Central

    Yu, Xiaodong; Zhang, Jian

    2014-01-01

    Based on the theory of hydraulic transients and the method of characteristics (MOC), a mathematic model of the differential surge tank with pressure-reduction orifices (PROs) and overflow weirs for transient calculation is proposed. The numerical model of hydraulic transients is established using the data of a practical hydropower station; and the probable transients are simulated. The results show that successive load rejection is critical for calculating the maximum pressure in spiral case and the maximum rotating speed of runner when the bifurcated pipe is converging under the surge tank in a diversion-type hydropower station; the pressure difference between two sides of breast wall is large during transient conditions, and it would be more serious when simultaneous load rejections happen after load acceptance; the reasonable arrangement of PROs on breast wall can effectively decrease the pressure difference. PMID:25133213

  15. Hydraulic transients in the long diversion-type hydropower station with a complex differential surge tank.

    PubMed

    Yu, Xiaodong; Zhang, Jian; Zhou, Ling

    2014-01-01

    Based on the theory of hydraulic transients and the method of characteristics (MOC), a mathematic model of the differential surge tank with pressure-reduction orifices (PROs) and overflow weirs for transient calculation is proposed. The numerical model of hydraulic transients is established using the data of a practical hydropower station; and the probable transients are simulated. The results show that successive load rejection is critical for calculating the maximum pressure in spiral case and the maximum rotating speed of runner when the bifurcated pipe is converging under the surge tank in a diversion-type hydropower station; the pressure difference between two sides of breast wall is large during transient conditions, and it would be more serious when simultaneous load rejections happen after load acceptance; the reasonable arrangement of PROs on breast wall can effectively decrease the pressure difference.

  16. A continued search for transient events in the COBE DMR database simultaneous with cosmic gamma-ray bursts

    NASA Astrophysics Data System (ADS)

    Stacy, J. Gregory; Jackson, Peter D.; Bontekoe, Tj. Romke; Winkler, Christoph

    1996-08-01

    We report on the status of our ongoing project to search the database of the COBE Differential Microwave Radiometer (DMR) experiment for transient signals at microwave wavelengths simultaneous with cosmic gamma-ray bursts (GRBs). To date we have carried out a complete search of the DMR database using burst positions taken from the original BATSE 1B catalog for the eight-month period of overlap (May-December 1991) corresponding to the first public release of COBE data. We are currently repeating our original search of the COBE DMR database using the revised burst positions of the newly-released BATSE 3B catalog. Using BATSE 1B positions, at least two apparent simultaneous observations of GRBs by the COBE DMR occurred in 1991, along with a number of ``near misses'' within 30 seconds in time. At present, only upper limits to burst microwave emission are indicated. Even in the event of a non-detection of a GRB by the COBE DMR, unprecedented observational limits will still be obtained, constraining the predictions of the many theoretical models proposed to explain the origin of GRBs.

  17. Femtosecond transient absorption spectroscopy study of the early events of norfloxacin in aqueous solutions with varying pH values.

    PubMed

    Su, Tao; Li, Ming-De; Ma, Jiani; Wong, Naikei; Phillips, David Lee

    2014-11-26

    The photophysics and photochemistry of norfloxacin (NF) have been investigated in aqueous solutions of different pH using femtosecond transient absorption spectroscopy (fs-TA). Resonance Raman spectroscopic experiments on NF have also been conducted in aqueous solutions of different pH to characterize the vibrational and structural information on the initial forms of NF. The experimental results in combination with density functional theory calculations of the key intermediates help us to elucidate the early events for NF after photoexcitation in aqueous solutions with varying pH values. The fs-TA results indicate that NF mainly underwent photophysical processes on the early delay time scale (before 3 ns), and no photochemical reactions occurred on this time scale. Specifically, after the irradiation of NF, the molecule reaches a higher excited singlet Sn and then decays to the lowest-lying excited singlet state S1 followed by intersystem crossing to transform into the lowest-lying triplet state T1 with a high efficiency, with an exception that there is a lower efficiency observed in basic aqueous solution due to the generation of an intramolecular electron transfer as an additional pathway to waste energy.

  18. Moonquakes and Transient Events

    ERIC Educational Resources Information Center

    Middlehurst, Barbara M.

    1973-01-01

    Reviews short term lunar surface changes gathered during the last decade and their relations to the seismic data from the four seismographs placed on the Moon. Indicates that such a continued consideration may give rise to a new insight into the structure of the Moon. (CC)

  19. Exciton exciton annihilation dynamics in chromophore complexes. II. Intensity dependent transient absorption of the LH2 antenna system.

    PubMed

    Bruggemann, B; May, V

    2004-02-01

    Using the multiexciton density matrix theory of excitation energy transfer in chromophore complexes developed in a foregoing paper [J. Chem. Phys. 118, 746 (2003)], the computation of ultrafast transient absorption spectra is presented. Beside static disorder and standard mechanisms of excitation energy dissipation the theory incorporates exciton exciton annihilation (EEA) processes. To elucidate signatures of EEA in intensity dependent transient absorption data the approach is applied to the B850 ring of the LH2 found in rhodobacter sphaeroides. As main indications for two-exciton population and resulting EEA we found (i) a weakening of the dominant single-exciton bleaching structure in the transient absorption, and (ii) an intermediate suppression of long-wavelength and short-wavelength shoulders around the bleaching structure. The suppression is caused by stimulated emission from the two-exciton to the one-exciton state and the return of the shoulders follows from a depletion of two-exciton population according to EEA. The EEA-signature survives as a short-wavelength shoulder in the transient absorption if orientational and energetic disorder are taken into account. Therefore, the observation of the EEA-signatures should be possible when doing frequency resolved transient absorption experiments with a sufficiently strongly varying pump-pulse intensity.

  20. Infrared signature of transient luminous events in the middle atmosphere simulated for a limb line of sight observation

    NASA Astrophysics Data System (ADS)

    Payan, Sebastien; Romand, Frederic; Laurence, Croizé

    2017-04-01

    Transient Luminous Events (TLE) are electrical and optical events which occurs above thunderstorms. Their occurrence is closely linked with the lightning activity below thunderstorms. TLEs are observed from the base of the stratosphere to the thermosphere (15 - 110 km). They are a very brief phenomenon which lasts from 1 to 300 milliseconds. At a worldwide scale, some to some tenths of TLEs occurs each minute. The energy deposition, about some tenths of megajoules, is able to ionize, dissociate and excite the molecules of the atmosphere. Then, a phase of recombination and relaxation starts. The interest of their study is multiple. In atmospheric chemistry we know that lightening are important sources of NOx in the troposphere, which indirectly influence the concentrations of O3 and OH. We wonder what could be the chemical effects of TLEs in the stratosphere and mesosphere. Experimentally, the HALESIS (High altitude Luminous Events Studied by Infrared Spectro-imagery) project aims to load a spectro-imager in a stratospheric balloon in order to measure atmospheric radiances in the moments following the electrical discharge of a TLE and then, to estimate the concentration of some components of interest (CO2, NO, O3, OH…) with spectrum inversions. In a Defense point of view, some airborne detection or guiding devices are equipped with infrared sensors, which may be disturbed by the TLEs infrared signal. The objective is to provide a tool which will describe the TLE phenomenon from the electric discharge to the detection threw an infrared sensor. To achieve this work we first compute the Non Local Thermodynamic Equilibrium population of a background atmosphere with the code SAMM2. The starting atmosphere comes from the Whole Atmosphere community Climate Model (WACCM). Then, we apply a TLE perturbation to a region of the background atmosphere. To do so we compute the plasma and atmospheric chemistry consecutive to the discharge of a TLE with the codes BOLSIG+ and

  1. Affective and Cardiovascular Responding to Unpleasant Events from Adolescence to Old Age: Complexity of Events Matters

    ERIC Educational Resources Information Center

    Wrzus, Cornelia; Muller, Viktor; Wagner, Gert G.; Lindenberger, Ulman; Riediger, Michaela

    2013-01-01

    Two studies investigated the "overpowering hypothesis" as a possible explanation for the currently inconclusive empirical picture on age differences in affective responding to unpleasant events. The overpowering hypothesis predicts that age differences in affective responding are particularly evident in highly resource-demanding situations that…

  2. Electrostatic Interactions in the Binding Pathway of a Transient Protein Complex Studied by NMR and Isothermal Titration Calorimetry*

    PubMed Central

    Meneses, Erick; Mittermaier, Anthony

    2014-01-01

    Much of our knowledge of protein binding pathways is derived from extremely stable complexes that interact very tightly, with lifetimes of hours to days. Much less is known about weaker interactions and transient complexes because these are challenging to characterize experimentally. Nevertheless, these types of interactions are ubiquitous in living systems. The combination of NMR relaxation dispersion Carr–Purcell–Meiboom–Gill (CPMG) experiments and isothermal titration calorimetry allows the quantification of rapid binding kinetics for complexes with submillisecond lifetimes that are difficult to study using conventional techniques. We have used this approach to investigate the binding pathway of the Src homology 3 (SH3) domain from the Fyn tyrosine kinase, which forms complexes with peptide targets whose lifetimes are on the order of about a millisecond. Long range electrostatic interactions have been shown to play a critical role in the binding pathways of tightly binding complexes. The role of electrostatics in the binding pathways of transient complexes is less well understood. Similarly to previously studied tight complexes, we find that SH3 domain association rates are enhanced by long range electrostatics, whereas short range interactions are formed late in the docking process. However, the extent of electrostatic association rate enhancement is several orders of magnitudes less, whereas the electrostatic-free basal association rate is significantly greater. Thus, the SH3 domain is far less reliant on electrostatic enhancement to achieve rapid association kinetics than are previously studied systems. This suggests that there may be overall differences in the role played by electrostatics in the binding pathways of extremely stable versus transient complexes. PMID:25122758

  3. Electrostatic interactions in the binding pathway of a transient protein complex studied by NMR and isothermal titration calorimetry.

    PubMed

    Meneses, Erick; Mittermaier, Anthony

    2014-10-03

    Much of our knowledge of protein binding pathways is derived from extremely stable complexes that interact very tightly, with lifetimes of hours to days. Much less is known about weaker interactions and transient complexes because these are challenging to characterize experimentally. Nevertheless, these types of interactions are ubiquitous in living systems. The combination of NMR relaxation dispersion Carr-Purcell-Meiboom-Gill (CPMG) experiments and isothermal titration calorimetry allows the quantification of rapid binding kinetics for complexes with submillisecond lifetimes that are difficult to study using conventional techniques. We have used this approach to investigate the binding pathway of the Src homology 3 (SH3) domain from the Fyn tyrosine kinase, which forms complexes with peptide targets whose lifetimes are on the order of about a millisecond. Long range electrostatic interactions have been shown to play a critical role in the binding pathways of tightly binding complexes. The role of electrostatics in the binding pathways of transient complexes is less well understood. Similarly to previously studied tight complexes, we find that SH3 domain association rates are enhanced by long range electrostatics, whereas short range interactions are formed late in the docking process. However, the extent of electrostatic association rate enhancement is several orders of magnitudes less, whereas the electrostatic-free basal association rate is significantly greater. Thus, the SH3 domain is far less reliant on electrostatic enhancement to achieve rapid association kinetics than are previously studied systems. This suggests that there may be overall differences in the role played by electrostatics in the binding pathways of extremely stable versus transient complexes.

  4. Transient dynamics and food-web complexity in the Lotka-Volterra cascade model.

    PubMed Central

    Chen, X.; Cohen, J. E.

    2001-01-01

    How does the long-term behaviour near equilibrium of model food webs correlate with their short-term transient dynamics? Here, simulations of the Lotka -Volterra cascade model of food webs provide the first evidence to answer this question. Transient behaviour is measured by resilience, reactivity, the maximum amplification of a perturbation and the time at which the maximum amplification occurs. Model food webs with a higher probability of local asymptotic stability may be less resilient and may have a larger transient growth of perturbations. Given a fixed connectance, the sizes and durations of transient responses to perturbations increase with the number of species. Given a fixed number of species, as connectance increases, the sizes and durations of transient responses to perturbations may increase or decrease depending on the type of link that is varied. Reactivity is more sensitive to changes in the number of donor-controlled links than to changes in the number of recipient-controlled links, while resilience is more sensitive to changes in the number of recipient-controlled links than to changes in the number of donor-controlled links. Transient behaviour is likely to be one of the important factors affecting the persistence of ecological communities. PMID:11345334

  5. Robot traders can prevent extreme events in complex stock markets

    NASA Astrophysics Data System (ADS)

    Suhadolnik, Nicolas; Galimberti, Jaqueson; Da Silva, Sergio

    2010-11-01

    If stock markets are complex, monetary policy and even financial regulation may be useless to prevent bubbles and crashes. Here, we suggest the use of robot traders as an anti-bubble decoy. To make our case, we put forward a new stochastic cellular automata model that generates an emergent stock price dynamics as a result of the interaction between traders. After introducing socially integrated robot traders, the stock price dynamics can be controlled, so as to make the market more Gaussian.

  6. Air-density-dependent model for analysis of air heating associated with streamers, leaders, and transient luminous events

    NASA Astrophysics Data System (ADS)

    Riousset, Jeremy A.; Pasko, Victor P.; Bourdon, Anne

    2010-12-01

    Blue and gigantic jets are transient luminous events in the middle atmosphere that form when conventional lightning leaders escape upward from the thundercloud. The conditions in the Earth's atmosphere (i.e., air density, reduced electric field, etc.) leading to conversion of hot leader channels driven by thermal ionization near cloud tops to nonthermal streamer forms observed at higher altitudes are not understood at present. This paper presents a formulation of a streamer-to-spark transition model that allows studies of gas dynamics and chemical kinetics involved in heating of air in streamer channels for a given air density N under assumption of constant applied electric field E. The model accounts for the dynamic expansion of the heated air in the streamer channel and resultant effects of E/N variations on plasma kinetics, the vibrational excitation of nitrogen molecules N2(v), effects of gains in electron energy in collisions with N2(v), and associative ionization processes involving N2(A3Σu+) and N2(a'1Σu-) species. The results are in excellent agreement with available experimental data at ground and near-ground air pressures and demonstrate that for the air densities corresponding to 0-70 km altitudes the kinetic effects lead to a significant acceleration of the heating, with effective heating times scaling closer to 1/N than to 1/N2 predicted on the basis of similarity laws for Joule heating. This acceleration is attributed to a strong reduction in electron losses due to three-body attachment and electron-ion recombination processes with reduction of air pressure.

  7. Physicochemical descriptors to discriminate protein-protein interactions in permanent and transient complexes selected by means of machine learning algorithms.

    PubMed

    Block, Peter; Paern, Juri; Hüllermeier, Eyke; Sanschagrin, Paul; Sotriffer, Christoph A; Klebe, Gerhard

    2006-11-15

    Analyzing protein-protein interactions at the atomic level is critical for our understanding of the principles governing the interactions involved in protein-protein recognition. For this purpose, descriptors explaining the nature of different protein-protein complexes are desirable. In this work, the authors introduced Epic Protein Interface Classification as a framework handling the preparation, processing, and analysis of protein-protein complexes for classification with machine learning algorithms. We applied four different machine learning algorithms: Support Vector Machines, C4.5 Decision Trees, K Nearest Neighbors, and Naïve Bayes algorithm in combination with three feature selection methods, Filter (Relief F), Wrapper, and Genetic Algorithms, to extract discriminating features from the protein-protein complexes. To compare protein-protein complexes to each other, the authors represented the physicochemical characteristics of their interfaces in four different ways, using two different atomic contact vectors, DrugScore pair potential vectors and SFCscore descriptor vectors. We classified two different datasets: (A) 172 protein-protein complexes comprising 96 monomers, forming contacts enforced by the crystallographic packing environment (crystal contacts), and 76 biologically functional homodimer complexes; (B) 345 protein-protein complexes containing 147 permanent complexes and 198 transient complexes. We were able to classify up to 94.8% of the packing enforced/functional and up to 93.6% of the permanent/transient complexes correctly. Furthermore, we were able to extract relevant features from the different protein-protein complexes and introduce an approach for scoring the importance of the extracted features. (c) 2006 Wiley-Liss, Inc.

  8. Enhancing Complex System Performance Using Discrete-Event Simulation

    SciTech Connect

    Allgood, Glenn O; Olama, Mohammed M; Lake, Joe E

    2010-01-01

    In this paper, we utilize discrete-event simulation (DES) merged with human factors analysis to provide the venue within which the separation and deconfliction of the system/human operating principles can occur. A concrete example is presented to illustrate the performance enhancement gains for an aviation cargo flow and security inspection system achieved through the development and use of a process DES. The overall performance of the system is computed, analyzed, and optimized for the different system dynamics. Various performance measures are considered such as system capacity, residual capacity, and total number of pallets waiting for inspection in the queue. These metrics are performance indicators of the system's ability to service current needs and respond to additional requests. We studied and analyzed different scenarios by changing various model parameters such as the number of pieces per pallet ratio, number of inspectors and cargo handling personnel, number of forklifts, number and types of detection systems, inspection modality distribution, alarm rate, and cargo closeout time. The increased physical understanding resulting from execution of the queuing model utilizing these vetted performance measures identified effective ways to meet inspection requirements while maintaining or reducing overall operational cost and eliminating any shipping delays associated with any proposed changes in inspection requirements. With this understanding effective operational strategies can be developed to optimally use personnel while still maintaining plant efficiency, reducing process interruptions, and holding or reducing costs.

  9. Intermolecular Paramagnetic Relaxation Enhancement (PRE) Studies of Transient Complexes in Intrinsically Disordered Proteins.

    PubMed

    Janowska, Maria K; Baum, Jean

    2016-01-01

    NMR interchain paramagnetic relaxation enhancement (PRE) techniques are a very powerful approach for detecting transient interchain interactions between intrinsically disordered proteins. These experiments, requiring a mixed sample containing a 1:1 ratio of isotope-labeled (15)N protein and natural abundance (14)N protein with a paramagnetic spin label, provide data that is limited to interchain interactions only. Application of these experiments to weakly associated transient species such as those that are present in the very early stages of self-assembly processes will aid our understanding of protein aggregation or fibril formation processes.

  10. Semantic Complex Event Processing over End-to-End Data Flows

    SciTech Connect

    Zhou, Qunzhi; Simmhan, Yogesh; Prasanna, Viktor K.

    2012-04-01

    Emerging Complex Event Processing (CEP) applications in cyber physical systems like SmartPower Grids present novel challenges for end-to-end analysis over events, flowing from heterogeneous information sources to persistent knowledge repositories. CEP for these applications must support two distinctive features - easy specification patterns over diverse information streams, and integrated pattern detection over realtime and historical events. Existing work on CEP has been limited to relational query patterns, and engines that match events arriving after the query has been registered. We propose SCEPter, a semantic complex event processing framework which uniformly processes queries over continuous and archived events. SCEPteris built around an existing CEP engine with innovative support for semantic event pattern specification and allows their seamless detection over past, present and future events. Specifically, we describe a unified semantic query model that can operate over data flowing through event streams to event repositories. Compile-time and runtime semantic patterns are distinguished and addressed separately for efficiency. Query rewriting is examined and analyzed in the context of temporal boundaries that exist between event streams and their repository to avoid duplicate or missing results. The design and prototype implementation of SCEPterare analyzed using latency and throughput metrics for scenarios from the Smart Grid domain.

  11. Event-related complexity analysis and its application in the detection of facial attractiveness.

    PubMed

    Deng, Zhidong; Zhang, Zimu

    2014-11-01

    In this study, an event-related complexity (ERC) analysis method is proposed and used to explore the neural correlates of facial attractiveness detection in the context of a cognitive experiment. The ERC method gives a quantitative index for measuring the diverse brain activation properties that represent the neural correlates of event-related responses. This analysis reveals distinct effects of facial attractiveness processing and also provides further information that could not have been achieved from event-related potential alone.

  12. Terrace width variations in complex Mercurian craters and the transient strength of cratered Mercurian and lunar crust

    NASA Technical Reports Server (NTRS)

    Leith, Andrew C.; Mckinnon, William B.

    1991-01-01

    The effective cohesion of the cratered region during crater collapse is determined via the widths of slump terraces of complex craters. Terrace widths are measured for complex craters on Mercury; these generally increase outward toward the rim for a given crater, and the width of the outermost major terrace is generally an increasing function of crater diameter. The terrace widths on Mercury and a gravity-driven slump model are used to estimate the strength of the cratered region immediately after impact (about 1-2 MPa). A comparison with the previous study of lunar complex craters by Pearce and Melosh (1986) indicates that the transient strength of cratered Mercurian crust is no greater than that of the moon. The strength estimates vary only slightly with the geometric model used to restore the outermost major terrace to its precollapse configuration and are consistent with independent strength estimates from the simple-to-complex crater depth/diameter transition.

  13. Multi-INT Complex Event Processing using Approximate, Incremental Graph Pattern Search

    DTIC Science & Technology

    2012-06-01

    2010. 4. Brandes U, Lerner J, TAB. Networks Evolving Step by Step: Statistical Analysis of Dyadic Event Data. Network Analysis. 2009:1-6...25. Mendes MRN, Bizarro P, Marques P. A framework for performance evaluation of complex event processing systems. Proceedings of the second

  14. Single-Event Transient Characterization of a Radiation-Tolerant Charge-Pump Phase-Locked Loop Fabricated in 130 nm PD-SOI Technology

    NASA Astrophysics Data System (ADS)

    Chen, Zhuojun; Lin, Min; Zheng, Yunlong; Wei, Zuodong; Huang, Shuigen; Zou, Shichang

    2016-08-01

    In this paper, a radiation-tolerant phase-locked loop (PLL) is designed and fabricated with 130 nm PD-SOI technology. A current-based charge pump is hardened using a current compensation technique in combination with the differential charge cancellation (DCC) layout of the complementary switches. Besides, the stacked SOI transistors are employed to mitigate single-event effects of the voltage-controlled oscillator. The experimental results show that the proposed PLL has no significant jitter variations under heavy-ion experiments, compared with TMR-hardened PLL. Besides, pulsed-laser testing comprehensively characterizes the single-event transients of the PLL and demonstrates its radiation tolerant performance.

  15. Statistical searches for microlensing events in large, non-uniformly sampled time-domain surveys: A test using palomar transient factory data

    SciTech Connect

    Price-Whelan, Adrian M.; Agüeros, Marcel A.; Fournier, Amanda P.; Street, Rachel; Ofek, Eran O.; Covey, Kevin R.; Levitan, David; Sesar, Branimir; Laher, Russ R.; Surace, Jason

    2014-01-20

    Many photometric time-domain surveys are driven by specific goals, such as searches for supernovae or transiting exoplanets, which set the cadence with which fields are re-imaged. In the case of the Palomar Transient Factory (PTF), several sub-surveys are conducted in parallel, leading to non-uniform sampling over its ∼20,000 deg{sup 2} footprint. While the median 7.26 deg{sup 2} PTF field has been imaged ∼40 times in the R band, ∼2300 deg{sup 2} have been observed >100 times. We use PTF data to study the trade off between searching for microlensing events in a survey whose footprint is much larger than that of typical microlensing searches, but with far-from-optimal time sampling. To examine the probability that microlensing events can be recovered in these data, we test statistics used on uniformly sampled data to identify variables and transients. We find that the von Neumann ratio performs best for identifying simulated microlensing events in our data. We develop a selection method using this statistic and apply it to data from fields with >10 R-band observations, 1.1 × 10{sup 9} light curves, uncovering three candidate microlensing events. We lack simultaneous, multi-color photometry to confirm these as microlensing events. However, their number is consistent with predictions for the event rate in the PTF footprint over the survey's three years of operations, as estimated from near-field microlensing models. This work can help constrain all-sky event rate predictions and tests microlensing signal recovery in large data sets, which will be useful to future time-domain surveys, such as that planned with the Large Synoptic Survey Telescope.

  16. Empirical support for the definition of a complex trauma event in children and adolescents.

    PubMed

    Wamser-Nanney, Rachel; Vandenberg, Brian R

    2013-12-01

    Complex trauma events have been defined as chronic, interpersonal traumas that begin early in life (Cook, Blaustein, Spinazzola, & van der Kolk, 2003). The complex trauma definition has been examined in adults, as indicated by the Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) field trial; however, this research was lacking in child populations. The symptom presentations of complexly traumatized children were contrasted with those exposed to other, less severe trauma ecologies that met 1 or 2 features of the complex trauma definition. Included in this study were 346 treatment-seeking children and adolescents (ages 3–18 years) who had experienced atraumatic event. Results indicated that child survivors of complex trauma presented with higher levels of generalized behavior problems and trauma-related symptoms than those who experienced (a) acute noninterpersonal trauma, (b) chronic interpersonal trauma that begins later in life, and (c) acute interpersonal trauma. Greater levels of behavioral problems were observed in children exposed to complex trauma as compared to those who experienced a traumatic event that begins early in life. These results provide support for the complex trauma event definition and suggest the need for a complex trauma diagnostic construct for children and adolescents.

  17. An extended grammar system for learning and recognizing complex visual events.

    PubMed

    Zhang, Zhang; Tan, Tieniu; Huang, Kaiqi

    2011-02-01

    For a grammar-based approach to the recognition of visual events, there are two major limitations that prevent it from real application. One is that the event rules are predefined by domain experts, which means huge manual cost. The other is that the commonly used grammar can only handle sequential relations between subevents, which is inadequate to recognize more complex events involving parallel subevents. To solve these problems, we propose an extended grammar approach to modeling and recognizing complex visual events. First, motion trajectories as original features are transformed into a set of basic motion patterns of a single moving object, namely, primitives (terminals) in the grammar system. Then, a Minimum Description Length (MDL) based rule induction algorithm is performed to discover the hidden temporal structures in primitive stream, where Stochastic Context-Free Grammar (SCFG) is extended by Allen's temporal logic to model the complex temporal relations between subevents. Finally, a Multithread Parsing (MTP) algorithm is adopted to recognize interesting complex events in a given primitive stream, where a Viterbi-like error recovery strategy is also proposed to handle large-scale errors, e.g., insertion and deletion errors. Extensive experiments, including gymnastic exercises, traffic light events, and multi-agent interactions, have been executed to validate the effectiveness of the proposed approach.

  18. Mechanism of Formation of Copper(II) Chloro Complexes Revealed by Transient Absorption Spectroscopy and DFT/TDDFT Calculations.

    PubMed

    Mereshchenko, Andrey S; Olshin, Pavel K; Karabaeva, Kanykey E; Panov, Maxim S; Wilson, R Marshall; Kochemirovsky, Vladimir A; Skripkin, Mikhail Yu; Tveryanovich, Yury S; Tarnovsky, Alexander N

    2015-07-16

    Copper(II) complexes are extremely labile with typical ligand exchange rate constants on the order of 10(6)-10(9) M(-1) s(-1). As a result, it is often difficult to identify the actual formation mechanism of these complexes. In this work, using UV-vis transient absorption when probing in a broad time range (20 ps to 8 μs) in conjunction with DFT/TDDFT calculations, we studied the dynamics and underlying reaction mechanisms of the formation of extremely labile copper(II) CuCl4(2-) chloro complexes from copper(II) CuCl3(-) trichloro complexes and chloride ions. These two species, produced via photochemical dissociation of CuCl4(2-) upon 420 nm excitation into the ligand-to-metal-charge-transfer electronic state, are found to recombine into parent complexes with bimolecular rate constants of (9.0 ± 0.1) × 10(7) and (5.3 ± 0.4) × 10(8) M(-1) s(-1) in acetonitrile and dichloromethane, respectively. In dichloromethane, recombination occurs via a simple one-step addition. In acetonitrile, where [CuCl3](-) reacts with the solvent to form a [CuCl3CH3CN](-) complex in less than 20 ps, recombination takes place via ligand exchange described by the associative interchange mechanism that involves a [CuCl4CH3CN](2-) intermediate. In both solvents, the recombination reaction is potential energy controlled.

  19. Mapping transiently formed and sparsely populated conformations on a complex energy landscape

    PubMed Central

    Wang, Yong; Papaleo, Elena; Lindorff-Larsen, Kresten

    2016-01-01

    Determining the structures, kinetics, thermodynamics and mechanisms that underlie conformational exchange processes in proteins remains extremely difficult. Only in favourable cases is it possible to provide atomic-level descriptions of sparsely populated and transiently formed alternative conformations. Here we benchmark the ability of enhanced-sampling molecular dynamics simulations to determine the free energy landscape of the L99A cavity mutant of T4 lysozyme. We find that the simulations capture key properties previously measured by NMR relaxation dispersion methods including the structure of a minor conformation, the kinetics and thermodynamics of conformational exchange, and the effect of mutations. We discover a new tunnel that involves the transient exposure towards the solvent of an internal cavity, and show it to be relevant for ligand escape. Together, our results provide a comprehensive view of the structural landscape of a protein, and point forward to studies of conformational exchange in systems that are less characterized experimentally. DOI: http://dx.doi.org/10.7554/eLife.17505.001 PMID:27552057

  20. Ultrafast dynamics of two copper bis-phenanthroline complexes measured by x-ray transient absorption spectroscopy

    NASA Astrophysics Data System (ADS)

    Kelley, Matthew S.; Shelby, Megan L.; Mara, Michael W.; Haldrup, Kristoffer; Hayes, Dugan; Hadt, Ryan G.; Zhang, Xiaoyi; Stickrath, Andrew B.; Ruppert, Romain; Sauvage, Jean-Pierre; Zhu, Diling; Lemke, Henrik T.; Chollet, Matthieu; Schatz, George C.; Chen, Lin X.

    2017-08-01

    Ultrafast structural dynamics of the metal to ligand charge transfer (MLCT) states of two copper bis-phenanthroline complexes were captured by using x-ray transient absorption (XTA) spectroscopy at the Linac Coherent Light Source and further described by theoretical calculations. These complexes have the general formula [Cu(I)(R)2]+, where R = 2,9-dimethyl-1,10-phenanthroline (dmp) and 2,9-diphenyl-1,10-phenanthroline disulfonic acid disodium salt (dpps). [Cu(I)(dmp)2]+ has methyl groups at the 2,9 positions of phenanthroline (phen) and adopts a pseudo-tetrahedral geometry. In contrast, [Cu(I)(dpps)2]+ possesses two bulky phenyl-sulfonate groups attached to each phen ligand that force the molecule to adopt a flattened tetrahedral geometry in the ground state. Previously, optical transient absorption (OTA) and synchrotron based XTA experiments with 100 ps time resolution have been employed to study the relationship between structural distortions and excited state relaxation pathways in the two complexes. However, the dynamics of the MLCT transition during the first few picoseconds after excitation in these complexes remained unclear because of limitations in element specificity in OTA and in the time resolution of synchrotron sources in XTA. In this experiment, the local coordination geometry and oxidation state of copper were probed with a temporal resolution of ∼300 fs. Unexpectedly, the depletion of the Cu(I) signal due to the MLCT transition was found to be non-impulsive in the case of [Cu(I)(dpps)2]+ with a time constant of 0.6 ps, while the Cu(I) depletion in [Cu(I)(dmp)2]+ was instantaneous within the 300 fs instrument response time. The slower Cu(I) depletion kinetics in [Cu(I)(dpps)2]+, previously unobserved in femtosecond OTA experiments, is likely due to intramolecular motions on the sub-picosecond time scale that could alter the localization of the transferred electron in the phen ligands.

  1. Complex active regions as the main source of extreme and large solar proton events

    NASA Astrophysics Data System (ADS)

    Ishkov, V. N.

    2013-12-01

    A study of solar proton sources indicated that solar flare events responsible for ≥2000 pfu proton fluxes mostly occur in complex active regions (CARs), i.e., in transition structures between active regions and activity complexes. Different classes of similar structures and their relation to solar proton events (SPEs) and evolution, depending on the origination conditions, are considered. Arguments in favor of the fact that sunspot groups with extreme dimensions are CARs are presented. An analysis of the flare activity in a CAR resulted in the detection of "physical" boundaries, which separate magnetic structures of the same polarity and are responsible for the independent development of each structure.

  2. The Top Chron C27n Event in the Western Atlantic: Evidence for a transient perturbation of the carbon cycle in the Late Danian?

    NASA Astrophysics Data System (ADS)

    Schulte, Peter; Bornemann, André; Speijer, Robert P.

    2010-05-01

    The Paleocene to early Eocene is punctuated by several transient, ˜20-200 ky lasting hyperthermal events of which the Paleocene-Eocene Thermal Maximum (PETM) was the most prominent one. Abrupt shallowing of the lysocline/CCD, negative carbon isotope excursions, and benthic faunal turnover all imply a major perturbation of the ocean system during these events. Our recent research at the Southern Tethyan shelf suggests the presence of an additional hyperthermal event associated with sea-level fluctuations, the Latest Danian Event (LDE; Speijer, 2003; Bornemann et al., 2009). At Zumaia, Northern Spain, a negative ~0.5 per mil carbon isotope excursion is present in the uppermost Danian that may correlate to the LDE (Arenillas et al. 2008). Moreover, cyclostratigraphic studies have shown that several deep-sea sites are characterized by a prominent peak in both Fe and MS data at cycle Pc100-38 in the uppermost Danian: this applies to all Walvis Ridge (Atlantic) and Shatsky Rise (Pacific) sites as well as Site 1001 in the Caribbean Sea (Top Chron C27n Event; Westerhold et al., 2007). These results suggest that the LDE in the Tethys and the Top Chron C27n Event in the Atlantic may be correlative. We have conducted mineralogical, geochemical, and micropaleontological investigations to characterize this event in the Western Atlantic. Our first results from ODP Leg 165 Site 1001 show that the Top Chron 27n Event shown by Westerhold el al. (2008) corresponds to a ~12 cm thick clay layer. Mineralogical analyses reveal a sharp ~50% drop of the carbonate content in the clay layer and a disproportionally high increase of the phyllosilicate content in the insoluble residue compared to the quartz and illite content. Bulk rock isotope analyses show an abrupt negative ~0.6 per mil carbon isotope excursion at the onset of the clay layer, followed by a 1-m thick interval where carbon isotopes shows a tailing back to pre-event values. The magnitude and pattern of the carbon isotope

  3. Ultrafast events in the electron photodetachment from the hexacyanoferrate(II) complex in solution

    NASA Astrophysics Data System (ADS)

    Pommeret, Stanislas; Naskrecki, Ryszard; van der Meulen, Peter; Ménard, Marjorie; Vigneron, Georges; Gustavsson, Thomas

    1998-05-01

    Following excitation of the hexacyanoferrate(II) complex in water with a 40 fs laser pulse at 267 nm, the absorption of the hydrated electron rises with a global time constant of 510 fs, whereas the characteristic absorption of the hexacyanoferrate(III) appears almost instantaneously. A transient absorption band around 490 nm is tentatively assigned to the charge-transfer-to-solvent (CTTS) state of the hexacyanoferrate(II). Its ultra-rapid decay (≪60 fs) is due to the electronic repulsion between the electron and its parent core.

  4. Transient association of the DNA-ligand complex during gel electrophoresis.

    PubMed

    Protozanova, E; Macgregor, R B

    1999-07-01

    DNA frayed wires are extremely stable multistranded complexes arising from the association of oligonucleotides with long terminal runs of consecutive guanines. Frayed wires originating from d(A15G15) have multiple binding sites for short complementary oligonucleotides such as dT10. We examine unusual band patterns obtained when complexes formed between dT10 and DNA frayed wires are resolved on nondenaturing polyacrylamide gels. Since the lifetime of the dT10-frayed wire complexes is shorter than the time of the gel run, the interaction between the components during the gel electrophoresis affects their band patterns. We have conducted chasing experiments to show that (i) the binding of dT10 to the frayed wires can occur during gel electrophoresis, and (ii) dissociation of the complexes occurs during the gel run. Rapid repetitive dissociation-reassociation of the complexes leads to a constant partitioning of dT10 between their binding sites within frayed wires. Consequently, complexes composed of frayed wires and various numbers of bound ligands appear on the gel as a single well-defined band. The mobilities of these bands decrease continuously with the concentration of the ligand reaching saturation when all the binding sites are occupied. This characteristic pattern is observed only for relatively unstable interactions. Longer ligands, i.e., oligonucleotides with higher affinity towards the binding sites, cease to exhibit the dynamic character of interaction during gel electrophoresis. These ligands form long-lived complexes with the frayed wires that appear on the gel as faint smeared bands reflecting the presence of multiple stable complexes.

  5. Effects of Grammaticality and Morphological Complexity on the P600 Event-Related Potential Component.

    PubMed

    Mehravari, Alison S; Tanner, Darren; Wampler, Emma K; Valentine, Geoffrey D; Osterhout, Lee

    2015-01-01

    We investigated interactions between morphological complexity and grammaticality on electrophysiological markers of grammatical processing during reading. Our goal was to determine whether morphological complexity and stimulus grammaticality have independent or additive effects on the P600 event-related potential component. Participants read sentences that were either well-formed or grammatically ill-formed, in which the critical word was either morphologically simple or complex. Results revealed no effects of complexity for well-formed stimuli, but the P600 amplitude was significantly larger for morphologically complex ungrammatical stimuli than for morphologically simple ungrammatical stimuli. These findings suggest that some previous work may have inadequately characterized factors related to reanalysis during morphosyntactic processing. Our results show that morphological complexity by itself does not elicit P600 effects. However, in ungrammatical circumstances, overt morphology provides a more robust and reliable cue to morphosyntactic relationships than null affixation.

  6. Generating and dimerizing the transient 16-electron phosphinidene complex [Cp*Ir=PAr]: a theoretical and experimental study.

    PubMed

    Termaten, Arjan T; Nijbacker, Tom; Ehlers, Andreas W; Schakel, Marius; Lutz, Martin; Spek, Anthony L; McKee, Michael L; Lammertsma, Koop

    2004-08-20

    The properties of the 16-electron phosphinidene complex [CpRIr=PR] were investigated experimentally and theoretically. Density functional theory calculations show a preferred bent geometry for the model complex [CpIr=PH], in contrast to the linear structure of [CpIr=NH]. Dimerization to give [[CpIr=PH]2] and ligand addition to afford [Cp(L)Ir=PH] (L=PH3, CO) were calculated to give compounds that were energetically highly favorable, but which differed from the related imido complexes. Transient 16-electron phosphinidene complex [Cp*Ir=PAr] could not be detected experimentally. Dehydrohalogenation of [Cp*IrCl2(PH2Ar)] in CH2Cl2 at low temperatures resulted in the novel fused-ring systems 17 (Ar=Mes*) and 20 (Ar=Mes), with dimeric [[Cp*Ir=PAr]2] being the likely intermediate. Intramolecular C-H bond activation induced by steric factors is considered to be the driving force for the irreversible formation of 17 and 20. ONIOM calculations suggest this arises because of the large steric congestion in [[Cp*Ir=PAr]2], which forces it toward a more reactive planar structure that is apt to rearrange.

  7. Everyday Matters in Science and Mathematics: Studies of Complex Classroom Events

    ERIC Educational Resources Information Center

    Nemirovsky, Ricardo, Ed.; Rosebery, Ann S., Ed.; Solomon, Jesse, Ed.; Warren, Beth, Ed.

    2005-01-01

    This book re-examines the dichotomy between the everyday and the disciplinary in mathematics and science education, and explores alternatives to this opposition from points of view grounded in the close examination of complex classroom events. It makes the case that students' everyday experience and knowledge in their entire manifold forms matter…

  8. Single Event Testing on Complex Devices: Test Like You Fly versus Test-Specific Design Structures

    NASA Technical Reports Server (NTRS)

    Berg, Melanie; LaBel, Kenneth A.

    2014-01-01

    We present a framework for evaluating complex digital systems targeted for harsh radiation environments such as space. Focus is limited to analyzing the single event upset (SEU) susceptibility of designs implemented inside Field Programmable Gate Array (FPGA) devices. Tradeoffs are provided between application-specific versus test-specific test structures.

  9. Plasticity in Single Axon Glutamatergic Connection to GABAergic Interneurons Regulates Complex Events in the Human Neocortex

    PubMed Central

    Szegedi, Viktor; Paizs, Melinda; Csakvari, Eszter; Molnar, Gabor; Barzo, Pal; Tamas, Gabor; Lamsa, Karri

    2016-01-01

    In the human neocortex, single excitatory pyramidal cells can elicit very large glutamatergic EPSPs (VLEs) in inhibitory GABAergic interneurons capable of triggering their firing with short (3–5 ms) delay. Similar strong excitatory connections between two individual neurons have not been found in nonhuman cortices, suggesting that these synapses are specific to human interneurons. The VLEs are crucial for generating neocortical complex events, observed as single pyramidal cell spike-evoked discharge of cell assemblies in the frontal and temporal cortices. However, long-term plasticity of the VLE connections and how the plasticity modulates neocortical complex events has not been studied. Using triple and dual whole-cell recordings from synaptically connected human neocortical layers 2–3 neurons, we show that VLEs in fast-spiking GABAergic interneurons exhibit robust activity-induced long-term depression (LTD). The LTD by single pyramidal cell 40 Hz spike bursts is specific to connections with VLEs, requires group I metabotropic glutamate receptors, and has a presynaptic mechanism. The LTD of VLE connections alters suprathreshold activation of interneurons in the complex events suppressing the discharge of fast-spiking GABAergic cells. The VLEs triggering the complex events may contribute to cognitive processes in the human neocortex, and their long-term plasticity can alter the discharging cortical cell assemblies by learning. PMID:27828957

  10. Everyday Matters in Science and Mathematics: Studies of Complex Classroom Events

    ERIC Educational Resources Information Center

    Nemirovsky, Ricardo, Ed.; Rosebery, Ann S., Ed.; Solomon, Jesse, Ed.; Warren, Beth, Ed.

    2005-01-01

    This book re-examines the dichotomy between the everyday and the disciplinary in mathematics and science education, and explores alternatives to this opposition from points of view grounded in the close examination of complex classroom events. It makes the case that students' everyday experience and knowledge in their entire manifold forms matter…

  11. The complex frequencies of long-period seismic events as probes of fluid composition beneath volcanoes

    USGS Publications Warehouse

    Kumagai, H.; Chouet, B.A.

    1999-01-01

    Long-period (LP) events have been widely observed in relation to magmatic and hydrothermal activities in volcanic areas. LP waveforms characterized by their harmonic signature have been interpreted as oscillations of a fluid-filled resonator, and mixtures of liquid and gas in the form of bubbly liquids have been mainly assumed for the fluid. To investigate the characteristic properties of the resonator system, we analyse waveforms of LP events observed at four different volcanoes in Hawaii, Alaska, Colombia and Japan using a newly developed spectral method. This method allows an estimation of the complex frequencies of decaying sinusoids based on an autoregressive model. The results of our analysis show a wide variety of Q factors, ranging from tens to several hundred. We compare these complex frequencies with those predicted by the fluid-filled crack model for various mixtures of liquid, gas and ash. Although the oscillations of LP events with Q smaller than 50 can be explained by various combinations of liquids and gases, we find that ash-laden gases are required to explain long-lasting oscillations with Q larger than 100. The complex frequencies of LP events yield useful information on the types of fluids. Temporal and spatial variations of the complex frequencies can be used as probes of fluid composition beneath volcanoes.

  12. Plasticity in Single Axon Glutamatergic Connection to GABAergic Interneurons Regulates Complex Events in the Human Neocortex.

    PubMed

    Szegedi, Viktor; Paizs, Melinda; Csakvari, Eszter; Molnar, Gabor; Barzo, Pal; Tamas, Gabor; Lamsa, Karri

    2016-11-01

    In the human neocortex, single excitatory pyramidal cells can elicit very large glutamatergic EPSPs (VLEs) in inhibitory GABAergic interneurons capable of triggering their firing with short (3-5 ms) delay. Similar strong excitatory connections between two individual neurons have not been found in nonhuman cortices, suggesting that these synapses are specific to human interneurons. The VLEs are crucial for generating neocortical complex events, observed as single pyramidal cell spike-evoked discharge of cell assemblies in the frontal and temporal cortices. However, long-term plasticity of the VLE connections and how the plasticity modulates neocortical complex events has not been studied. Using triple and dual whole-cell recordings from synaptically connected human neocortical layers 2-3 neurons, we show that VLEs in fast-spiking GABAergic interneurons exhibit robust activity-induced long-term depression (LTD). The LTD by single pyramidal cell 40 Hz spike bursts is specific to connections with VLEs, requires group I metabotropic glutamate receptors, and has a presynaptic mechanism. The LTD of VLE connections alters suprathreshold activation of interneurons in the complex events suppressing the discharge of fast-spiking GABAergic cells. The VLEs triggering the complex events may contribute to cognitive processes in the human neocortex, and their long-term plasticity can alter the discharging cortical cell assemblies by learning.

  13. Single-molecule measurements of transient biomolecular complexes through microfluidic dilution.

    PubMed

    Horrocks, Mathew H; Rajah, Luke; Jönsson, Peter; Kjaergaard, Magnus; Vendruscolo, Michele; Knowles, Tuomas P J; Klenerman, David

    2013-07-16

    Single-molecule confocal microscopy experiments require concentrations which are low enough to guarantee that, on average, less than one single molecule resides in the probe volume at any given time. Such concentrations are, however, significantly lower than the dissociation constants of many biological complexes which can therefore dissociate under single-molecule conditions. To address the challenge of observing weakly bound complexes in single-molecule experiments in solution, we have designed a microfluidic device that rapidly dilutes samples by up to one hundred thousand times, allowing the observation of unstable complexes before they dissociate. The device can interface with standard biochemistry laboratory experiments and generates a spatially uniform dilution that is stable over time allowing the quantification of the relative concentrations of different molecular species.

  14. Sensitivity analysis of some critical factors affecting simulated intrusion volumes during a low pressure transient event in a full-scale water distribution system.

    PubMed

    Ebacher, G; Besner, M C; Clément, B; Prévost, M

    2012-09-01

    Intrusion events caused by transient low pressures may result in the contamination of a water distribution system (DS). This work aims at estimating the range of potential intrusion volumes that could result from a real downsurge event caused by a momentary pump shutdown. A model calibrated with transient low pressure recordings was used to simulate total intrusion volumes through leakage orifices and submerged air vacuum valves (AVVs). Four critical factors influencing intrusion volumes were varied: the external head of (untreated) water on leakage orifices, the external head of (untreated) water on submerged air vacuum valves, the leakage rate, and the diameter of AVVs' outlet orifice (represented by a multiplicative factor). Leakage orifices' head and AVVs' orifice head levels were assessed through fieldwork. Two sets of runs were generated as part of two statistically designed experiments. A first set of 81 runs was based on a complete factorial design in which each factor was varied over 3 levels. A second set of 40 runs was based on a latin hypercube design, better suited for experimental runs on a computer model. The simulations were conducted using commercially available transient analysis software. Responses, measured by total intrusion volumes, ranged from 10 to 366 L. A second degree polynomial was used to analyze the total intrusion volumes. Sensitivity analyses of both designs revealed that the relationship between the total intrusion volume and the four contributing factors is not monotonic, with the AVVs' orifice head being the most influential factor. When intrusion through both pathways occurs concurrently, interactions between the intrusion flows through leakage orifices and submerged AVVs influence intrusion volumes. When only intrusion through leakage orifices is considered, the total intrusion volume is more largely influenced by the leakage rate than by the leakage orifices' head. The latter mainly impacts the extent of the area affected by

  15. Fragmented QRS complex predicts the arrhythmic events in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia.

    PubMed

    Canpolat, Uğur; Kabakçi, Giray; Aytemir, Kudret; Dural, Muhammet; Sahiner, Levent; Yorgun, Hikmet; Sunman, Hamza; Bariş Kaya, Ergün; Tokgözoğlu, Lale; Oto, Ali

    2013-11-01

    Fragmented QRS (frQRS) complex, with various morphology, has been recently described as a diagnostic criterion of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D). However, there are little data regarding the prognostic role of frQRS in these patients. Therefore, we aimed to investigate the association of frQRS with arrhythmic events in patients with ARVC/D. Seventy-eight patients (51 men, 65.4%; mean age: 31.25 ± 11.5 years) with the diagnosis of ARVC/D according to 2010 modified Task Force Criteria were analyzed retrospectively. Baseline ECG evaluation revealed frQRS complex in 46 patients (59%). Eleven patients with complete/incomplete right bundle branch block were excluded from the study. The phenomenon of frQRS was defined as deflections at the beginning of the QRS complex, on top of the R-wave, or in the nadir of the S-wave similar to the definition in CAD in either one right precordial lead or in more than one lead including all standard ECG leads. During 38 ± 14 months follow-up period, 3 patients (3.8%) died suddenly, 36 patients (46.1%) experienced arrhythmic events (32 ventricular tachycardias [VTs] and 4 ventricular fibrillation [VF], 30 in the ICD group). The frQRS was significantly associated with arrhythmic events (P < 0.001). Also, the number of ECG leads with frQRS complex was higher in patients with arrhythmic events (5.08 ± 2.5 vs 1.14 ± 1.7, P < 0.001, respectively). The frQRS complex on standard 12-lead ECG predicts fatal and nonfatal arrhythmic events in patients with ARVC/D. Therefore, large scale and prospective studies are needed to confirm those findings. © 2013 Wiley Periodicals, Inc.

  16. Pre-trained D-CNN models for detecting complex events in unconstrained videos

    NASA Astrophysics Data System (ADS)

    Robinson, Joseph P.; Fu, Yun

    2016-05-01

    Rapid event detection faces an emergent need to process large videos collections; whether surveillance videos or unconstrained web videos, the ability to automatically recognize high-level, complex events is a challenging task. Motivated by pre-existing methods being complex, computationally demanding, and often non-replicable, we designed a simple system that is quick, effective and carries minimal overhead in terms of memory and storage. Our system is clearly described, modular in nature, replicable on any Desktop, and demonstrated with extensive experiments, backed by insightful analysis on different Convolutional Neural Networks (CNNs), as stand-alone and fused with others. With a large corpus of unconstrained, real-world video data, we examine the usefulness of different CNN models as features extractors for modeling high-level events, i.e., pre-trained CNNs that differ in architectures, training data, and number of outputs. For each CNN, we use 1-fps from all training exemplar to train one-vs-rest SVMs for each event. To represent videos, frame-level features were fused using a variety of techniques. The best being to max-pool between predetermined shot boundaries, then average-pool to form the final video-level descriptor. Through extensive analysis, several insights were found on using pre-trained CNNs as off-the-shelf feature extractors for the task of event detection. Fusing SVMs of different CNNs revealed some interesting facts, finding some combinations to be complimentary. It was concluded that no single CNN works best for all events, as some events are more object-driven while others are more scene-based. Our top performance resulted from learning event-dependent weights for different CNNs.

  17. Comparison of Single-Event Transients Induced in an Operational Amplifier (LM124) by Pulsed Laser Light and a Broad Beam of Heavy Ions

    NASA Technical Reports Server (NTRS)

    Buchner, Steve; McMorrow, Dale; Poivey, Christian; Howard, James, Jr.; Pease, Rom; Savage, Mark; Boulghassoul, Younis; Massengill, Lloyd

    2003-01-01

    A comparison of transients from heavy-ion and pulsed-laser testing shows good agreement for many different voltage configurations. The agreement is illustrated by comparing directly individual transients and plots of transient amplitude versus width.

  18. Comparison of Single-Event Transients Induced in an Operational Amplifier (LM124) by Pulsed Laser Light and a Broad Beam of Heavy Ions

    NASA Technical Reports Server (NTRS)

    Buchner, Steve; McMorrow, Dale; Poivey, Christian; Howard, James, Jr.; Pease, Rom; Savage, Mark; Boulghassoul, Younis; Massengill, Lloyd

    2003-01-01

    A comparison of transients from heavy-ion and pulsed-laser testing shows good agreement for many different voltage configurations. The agreement is illustrated by comparing directly individual transients and plots of transient amplitude versus width.

  19. Transient emotional events and individual affective traits affect emotion recognition in a perceptual decision-making task

    PubMed Central

    Garcia Quesada, Maria; Antico, Lia; Bavelier, Daphne; Vuilleumier, Patrik; Pichon, Swann

    2017-01-01

    Both affective states and personality traits shape how we perceive the social world and interpret emotions. The literature on affective priming has mostly focused on brief influences of emotional stimuli and emotional states on perceptual and cognitive processes. Yet this approach does not fully capture more dynamic processes at the root of emotional states, with such states lingering beyond the duration of the inducing external stimuli. Our goal was to put in perspective three different types of affective states (induced affective states, more sustained mood states and affective traits such as depression and anxiety) and investigate how they may interact and influence emotion perception. Here, we hypothesized that absorption into positive and negative emotional episodes generate sustained affective states that outlast the episode period and bias the interpretation of facial expressions in a perceptual decision-making task. We also investigated how such effects are influenced by more sustained mood states and by individual affect traits (depression and anxiety) and whether they interact. Transient emotional states were induced using movie-clips, after which participants performed a forced-choice emotion classification task with morphed facial expressions ranging from fear to happiness. Using a psychometric approach, we show that negative (vs. neutral) clips increased participants’ propensity to classify ambiguous faces as fearful during several minutes. In contrast, positive movies biased classification toward happiness only for those clips perceived as most absorbing. Negative mood, anxiety and depression had a stronger effect than transient states and increased the propensity to classify ambiguous faces as fearful. These results provide the first evidence that absorption and different temporal dimensions of emotions have a significant effect on how we perceive facial expressions. PMID:28151976

  20. Transient emotional events and individual affective traits affect emotion recognition in a perceptual decision-making task.

    PubMed

    Qiao-Tasserit, Emilie; Garcia Quesada, Maria; Antico, Lia; Bavelier, Daphne; Vuilleumier, Patrik; Pichon, Swann

    2017-01-01

    Both affective states and personality traits shape how we perceive the social world and interpret emotions. The literature on affective priming has mostly focused on brief influences of emotional stimuli and emotional states on perceptual and cognitive processes. Yet this approach does not fully capture more dynamic processes at the root of emotional states, with such states lingering beyond the duration of the inducing external stimuli. Our goal was to put in perspective three different types of affective states (induced affective states, more sustained mood states and affective traits such as depression and anxiety) and investigate how they may interact and influence emotion perception. Here, we hypothesized that absorption into positive and negative emotional episodes generate sustained affective states that outlast the episode period and bias the interpretation of facial expressions in a perceptual decision-making task. We also investigated how such effects are influenced by more sustained mood states and by individual affect traits (depression and anxiety) and whether they interact. Transient emotional states were induced using movie-clips, after which participants performed a forced-choice emotion classification task with morphed facial expressions ranging from fear to happiness. Using a psychometric approach, we show that negative (vs. neutral) clips increased participants' propensity to classify ambiguous faces as fearful during several minutes. In contrast, positive movies biased classification toward happiness only for those clips perceived as most absorbing. Negative mood, anxiety and depression had a stronger effect than transient states and increased the propensity to classify ambiguous faces as fearful. These results provide the first evidence that absorption and different temporal dimensions of emotions have a significant effect on how we perceive facial expressions.

  1. Characterization of Complex Systems Using the Design of Experiments Approach: Transient Protein Expression in Tobacco as a Case Study

    PubMed Central

    Buyel, Johannes Felix; Fischer, Rainer

    2014-01-01

    Plants provide multiple benefits for the production of biopharmaceuticals including low costs, scalability, and safety. Transient expression offers the additional advantage of short development and production times, but expression levels can vary significantly between batches thus giving rise to regulatory concerns in the context of good manufacturing practice. We used a design of experiments (DoE) approach to determine the impact of major factors such as regulatory elements in the expression construct, plant growth and development parameters, and the incubation conditions during expression, on the variability of expression between batches. We tested plants expressing a model anti-HIV monoclonal antibody (2G12) and a fluorescent marker protein (DsRed). We discuss the rationale for selecting certain properties of the model and identify its potential limitations. The general approach can easily be transferred to other problems because the principles of the model are broadly applicable: knowledge-based parameter selection, complexity reduction by splitting the initial problem into smaller modules, software-guided setup of optimal experiment combinations and step-wise design augmentation. Therefore, the methodology is not only useful for characterizing protein expression in plants but also for the investigation of other complex systems lacking a mechanistic description. The predictive equations describing the interconnectivity between parameters can be used to establish mechanistic models for other complex systems. PMID:24514765

  2. Characterization of complex systems using the design of experiments approach: transient protein expression in tobacco as a case study.

    PubMed

    Buyel, Johannes Felix; Fischer, Rainer

    2014-01-31

    Plants provide multiple benefits for the production of biopharmaceuticals including low costs, scalability, and safety. Transient expression offers the additional advantage of short development and production times, but expression levels can vary significantly between batches thus giving rise to regulatory concerns in the context of good manufacturing practice. We used a design of experiments (DoE) approach to determine the impact of major factors such as regulatory elements in the expression construct, plant growth and development parameters, and the incubation conditions during expression, on the variability of expression between batches. We tested plants expressing a model anti-HIV monoclonal antibody (2G12) and a fluorescent marker protein (DsRed). We discuss the rationale for selecting certain properties of the model and identify its potential limitations. The general approach can easily be transferred to other problems because the principles of the model are broadly applicable: knowledge-based parameter selection, complexity reduction by splitting the initial problem into smaller modules, software-guided setup of optimal experiment combinations and step-wise design augmentation. Therefore, the methodology is not only useful for characterizing protein expression in plants but also for the investigation of other complex systems lacking a mechanistic description. The predictive equations describing the interconnectivity between parameters can be used to establish mechanistic models for other complex systems.

  3. Field in a complex cylindrical/coaxial cavity subject to time-harmonic and transient excitation

    NASA Astrophysics Data System (ADS)

    Bopp, Charles L.; Butler, Chalmers M.

    2004-12-01

    A coupled integral-equation method for calculating fields in complex cavities is developed and is applied to cavities comprising multiple cascaded and overlapping coaxial and circular-cylindrical regions or sections. The field in a section is related to the fields in apertures of planar conducting surfaces, which bound the section. Laboratory cavities are constructed, and their fields are computed from numerical solutions of the integral equations. The results are compared with data obtained through measurements in both the frequency and time domains. The accuracy of the method is also verified by comparison of measured and calculated values of the current and charge on cavity walls. The tools developed are used to investigate the salient features of a sine burst that passes through the complex cavity.

  4. Interfacial Hydration, Dynamics and Electron Transfer: Multi-Scale ET Modeling of the Transient [Myoglobin, Cytochrome b5] Complex

    PubMed Central

    Keinan, Shahar; Nocek, Judith M.; Beratan, David N.; Hoffman, Brian M.

    2012-01-01

    Formation of a transient [myoglobin (Mb), cytochrome b5 (cyt b5)] complex is required for the reductive repair of inactive ferri-Mb to its functional ferro-Mb state. The [Mb, cyt b5] complex exhibits dynamic docking (DD), with its cyt b5 partner in rapid exchange at multiple sites on the Mb surface. A triple mutant (Mb(3M)) was designed as part of efforts to shift the electron-transfer process to the simple docking (SD) regime, in which reactive binding occurs at a restricted, reactive region on the Mb surface that dominates the docked ensemble.1 An electrostatically-guided Brownian dynamics (BD) docking protocol was used to generate an initial ensemble of reactive configurations of the complex between unrelaxed partners. This ensemble samples a broad and diverse array of heme-heme distances and orientations. These configurations seeded all-atom constrained molecular dynamics simulations (MD) to generate relaxed complexes for the calculation of electron tunneling matrix elements (TDA) through tunneling-pathway analysis. This procedure for generating an ensemble of relaxed complexes combines the ability of BD calculations to sample the large variety of available conformations and interprotein distances, with the ability of MD to generate the atomic level information, especially regarding the structure of water molecules at the protein-protein interface, that defines electron-tunneling pathways. We used the calculated TDA values to compute ET rates for the [Mb(wt), cyt b5] complex and for the complex with a mutant that has a binding free energy strengthened by three D/E → K charge-reversal mutations, [Mb(3M), cyt b5]. The calculated rate constants are in agreement with the measured values, and the mutant complex ensemble has many more geometries with higher TDA values than does the wild-type Mb complex. Interestingly, water plays a double role in this electron-transfer system, lowering the tunneling barrier as well as inducing protein interface remodeling that

  5. Diagnostic usefulness of the ABCD2 score to distinguish transient ischemic attack and minor ischemic stroke from noncerebrovascular events: the North Dublin TIA Study.

    PubMed

    Sheehan, Orla C; Merwick, Aine; Kelly, Lisa A; Hannon, Niamh; Marnane, Michael; Kyne, Lorraine; McCormack, Patricia M E; Duggan, Joseph; Moore, Alan; Moroney, Joan; Daly, Leslie; Harris, Dawn; Horgan, Gillian; Kelly, Peter J

    2009-11-01

    Transient ischemic attack (TIA) diagnosis is frequently difficult in clinical practice. Noncerebrovascular symptoms are often misclassified as TIA by nonspecialist physicians. Clinical prediction rules such as ABCD(2) improve the identification of patients with TIA at high risk of early stroke. We hypothesized that the ABCD(2) score may partly improve risk stratification due to improved discrimination of true TIA and minor ischemic stroke (MIS) from noncerebrovascular events. Consecutive patients with TIA were identified within a prospective population-based cohort study of stroke and TIA. The cohort was expanded by inclusion of patients with MIS and noncerebrovascular events referred to a daily TIA clinic serving the population. Diagnosis was assigned by a trained stroke physician independent of ABCD(2) score. Five hundred ninety-four patients were included (292 [49.2%] TIA, 45 [7.6%] MIS, and 257 [43.3%] noncerebrovascular). The mean ABCD(2) score showed a graded increase across diagnostic groups (MIS mean 4.8 [SD 1.4] versus TIA mean 3.9 [SD 1.5] versus noncerebrovascular mean 2.9 [SD 1.5]; P<0.00001). The ABCD(2) score discriminated well between noncerebrovascular and cerebrovascular events-TIA (c-statistic 0.68; 95% CI, 0.64 to 0.72), any vascular event (TIA+MIS; c-statistic 0.7; 95% CI, 0.66 to 0.74), and MIS (c-statistic 0.81; 95% CI, 0.75 to 0.87)-from noncerebrovascular events. Of ABCD(2) items, unilateral weakness (OR, 4.5; 95% CI, 3.1 to 6.6) and speech disturbance (OR, 2.5; 95% CI, 1.6, 4.1) were most likely overrepresented in TIA compared with noncerebrovascular groups. The ABCD(2) score had significant diagnostic usefulness for discrimination of true TIA and MIS from noncerebrovascular events, which may contribute to its predictive usefulness.

  6. Duration of Symptom and ABCD2 Score as Predictors of Risk of Early Recurrent Events after Transient Ischemic Attack: A Hospital-Based Case Series Study

    PubMed Central

    Li, Qiang; Zhu, Xiaolong; Feng, Chao; Fang, Min; Liu, Xueyuan

    2015-01-01

    Background The aim of this study was to refine clinical risk factor stratification and make an optimal intervention plan to prevent ischemic stroke. Material/Methods Clinical data, including diffusion-weighted imaging (DWI) findings, were collected in a cohort of hospitalized transient ischemic attack (TIA) patients from January 2010 to December 2011. Recurrent cerebrovascular events after TIA, including recurrent TIA, minor stroke, and major stroke, were identified by face-to-face follow-up. A multivariate, ordinal, logistic regression model was used to determine significant predictors of recurrent events. Results Of 106 TIA patients, 24 (22.6%) had recurrent TIA and 20 (18.9%) had a stroke within 7 days. Hypertension, dyslipidemia, a history of ischemic stroke or TIA, and ABCD2 score were significantly associated with the recurrent events after TIA (P<0.001, P=0.02, P<0.001, P=0.02). Hypertension (RR=9.21; 95% CI, 3.07–27.61, P<0.001) and duration of symptom (RR=1.10; 95% CI, 1.02–1.17, P=0.01) as an item of ABCD2 score were highly predictive of the severity of recurrent events, whereas ABCD2 score as a whole (P=0.18) proved to be less strongly predictive. Conclusions A history of hypertension and long duration of symptom independently and significantly predict severe recurrent events after TIA within 7 days, but a high ABCD2 score was less strongly predictive of severe recurrent events. PMID:25604068

  7. Statistics and characteristics of spatiotemporally rare intense events in complex Ginzburg-Landau models.

    PubMed

    Kim, Jong-Won; Ott, Edward

    2003-02-01

    We study the statistics and characteristics of rare intense events in two types of two-dimensional complex Ginzburg-Landau (CGL) equation based models. Our numerical simulations show finite amplitude collapselike solutions which approach the infinite amplitude solutions of the nonlinear Schrödinger equation in an appropriate parameter regime. We also determine the probability distribution function of the amplitude of the CGL solutions, which is found to have enhanced (as compared to Gaussian) probability for the amplitude to be large. Our results suggest a general picture in which an incoherent background of weakly interacting waves, occasionally, "by chance," initiates intense, coherent, self-reinforcing, highly nonlinear events.

  8. Neural bases of event knowledge and syntax integration in comprehension of complex sentences.

    PubMed

    Malaia, Evie; Newman, Sharlene

    2015-01-01

    Comprehension of complex sentences is necessarily supported by both syntactic and semantic knowledge, but what linguistic factors trigger a readers' reliance on a specific system? This functional neuroimaging study orthogonally manipulated argument plausibility and verb event type to investigate cortical bases of the semantic effect on argument comprehension during reading. The data suggest that telic verbs facilitate online processing by means of consolidating the event schemas in episodic memory and by easing the computation of syntactico-thematic hierarchies in the left inferior frontal gyrus. The results demonstrate that syntax-semantics integration relies on trade-offs among a distributed network of regions for maximum comprehension efficiency.

  9. Correlative light and volume electron microscopy: using focused ion beam scanning electron microscopy to image transient events in model organisms.

    PubMed

    Bushby, Andrew J; Mariggi, Giovanni; Armer, Hannah E J; Collinson, Lucy M

    2012-01-01

    The study of a biological event within a live model organism has become routine through the use of fluorescent labeling of specific proteins in conjunction with laser confocal imaging. These methods allow 3D visualization of temporal events that can elucidate biological function but cannot resolve the tissue organization, extracellular and subcellular details of the tissues. Here, we present a method for correlating electron microscopy image data with the light microscopy data from the same sample volume to reveal the 3D structural information: "correlative light and volume electron microscopy." The methods for live video confocal microscopy, fixation and embedding of the tissue for electron microscopy, the focused ion beam scanning electron microscopy method for sequentially slicing and imaging the volume of interest, and the treatment of the resulting 3D dataset are presented. The method is illustrated with data collected during the angiogenesis of blood vessels in a transgenic zebrafish embryo. Copyright © 2012 Elsevier Inc. All rights reserved.

  10. Real time measurement of transient event emissions of air toxics by tomographic remote sensing in tandem with mobile monitoring

    NASA Astrophysics Data System (ADS)

    Olaguer, Eduardo P.; Stutz, Jochen; Erickson, Matthew H.; Hurlock, Stephen C.; Cheung, Ross; Tsai, Catalina; Colosimo, Santo F.; Festa, James; Wijesinghe, Asanga; Neish, Bradley S.

    2017-02-01

    During the Benzene and other Toxics Exposure (BEE-TEX) study, a remote sensing network based on long path Differential Optical Absorption Spectroscopy (DOAS) was set up in the Manchester neighborhood beside the Ship Channel of Houston, Texas in order to perform Computer Aided Tomography (CAT) scans of hazardous air pollutants. On 18-19 February 2015, the CAT scan network detected large nocturnal plumes of toluene and xylenes most likely associated with railcar loading and unloading operations at Ship Channel petrochemical facilities. The presence of such plumes during railcar operations was confirmed by a mobile laboratory equipped with a Proton Transfer Reaction-Mass Spectrometer (PTR-MS), which measured transient peaks of toluene and C2-benzenes of 50 ppb and 57 ppb respectively around 4 a.m. LST on 19 February 2015. Plume reconstruction and source attribution were performed using the 4D variational data assimilation technique and a 3D micro-scale forward and adjoint air quality model based on both tomographic and PTR-MS data. Inverse model estimates of fugitive emissions associated with railcar transfer emissions ranged from 2.0 to 8.2 kg/hr for toluene and from 2.2 to 3.5 kg/hr for xylenes in the early morning of 19 February 2015.

  11. Voyager 1 Observations of a Recent Transient Disturbance in the Interstellar Medium Caused by an Energetic Solar Event

    NASA Astrophysics Data System (ADS)

    Gurnett, D. A.; Kurth, W. S.; Stone, E. C.; Cummings, A. C.; Krimigis, S. M.; Decker, R. B.; Ness, N. F.; Burlaga, L. F.

    2016-12-01

    In late August 2012 the Voyager 1 spacecraft crossed the heliopause into the nearby interstellar medium. Since then the spacecraft has detected four distinct particle and field disturbances in the interstellar plasma, each believed to be produced by a shock originating from a solar event. Here we describe the fourth and most recent of these events. This event was first identified in the Low Energy Charged Particle (LECP) and Cosmic Ray (CRS) data around day 1, 2015, by the onset of a gradual downward trend in the intensity of galactic cosmic rays near 90° pitch angles. This decrease was briefly interrupted by a small recovery, and then resumed the decrease on day 100, 2015. The downward trend was followed about half a year later by the onset of intense bursts of electron plasma oscillations on day 250, 2015. The plasma oscillations continued with high intensities, the highest intensities yet observed, to about day 310, 2015, where they abruptly ended. The oscillation frequency was around 3.0 kHz, which corresponds to a local electron density of 0.11 cm-3, the highest yet measured in the interstellar medium. Near the end of the year, day 1, 2016, the downward trend in the 90° cosmic ray intensities reversed and started increasing, but has not yet returned to isotropy as of this writing. At the minimum, the 90° cosmic ray intensity at 200 MeV was depressed about 10% below the isotropic value. Overall, the new event has very similar characteristics to the three previous events, although differing in some details and of somewhat longer in duration. Most striking is the depression in the cosmic ray intensity near 90° pitch angles which in every case precedes the onset of the electron plasma oscillations. Since the electron plasma oscillations have been widely interpreted as being driven by electron beams streaming out ahead of an approaching shock (two of which have been directly detected), it appears that the depression in the cosmic ray intensities near 90° pitch

  12. Complex network based techniques to identify extreme events and (sudden) transitions in spatio-temporal systems.

    PubMed

    Marwan, Norbert; Kurths, Jürgen

    2015-09-01

    We present here two promising techniques for the application of the complex network approach to continuous spatio-temporal systems that have been developed in the last decade and show large potential for future application and development of complex systems analysis. First, we discuss the transforming of a time series from such systems to a complex network. The natural approach is to calculate the recurrence matrix and interpret such as the adjacency matrix of an associated complex network, called recurrence network. Using complex network measures, such as transitivity coefficient, we demonstrate that this approach is very efficient for identifying qualitative transitions in observational data, e.g., when analyzing paleoclimate regime transitions. Second, we demonstrate the use of directed spatial networks constructed from spatio-temporal measurements of such systems that can be derived from the synchronized-in-time occurrence of extreme events in different spatial regions. Although there are many possibilities to investigate such spatial networks, we present here the new measure of network divergence and how it can be used to develop a prediction scheme of extreme rainfall events.

  13. Complex Biological Event Extraction from Full Text using Signatures of Linguistic and Semantic Features

    SciTech Connect

    McGrath, Liam R.; Domico, Kelly O.; Corley, Courtney D.; Webb-Robertson, Bobbie-Jo M.

    2011-06-24

    Building on technical advances from the BioNLP 2009 Shared Task Challenge, the 2011 challenge sets forth to generalize techniques to other complex biological event extraction tasks. In this paper, we present the implementation and evaluation of a signature-based machine-learning technique to predict events from full texts of infectious disease documents. Specifically, our approach uses novel signatures composed of traditional linguistic features and semantic knowledge to predict event triggers and their candidate arguments. Using a leave-one out analysis, we report the contribution of linguistic and shallow semantic features in the trigger prediction and candidate argument extraction. Lastly, we examine evaluations and posit causes for errors of infectious disease track subtasks.

  14. Online transient isotachophoresis concentration by the pseudo-terminating electrolyte buffer for the separation of DNA-aptamer and its thrombin complex in poly(methyl methacrylate) microchip.

    PubMed

    Wang, Jun; Zhang, Yong; Okamoto, Yukihiro; Kaji, Noritada; Tokeshi, Manabu; Baba, Yoshinobu

    2011-03-21

    Online automatic transient isotachophoresis concentration of DNA-aptamer and its thrombin complex by using one kind of pseudo-terminating electrolyte buffer in a cross-channel poly(methyl methacrylate) microchip is reported. Sample injection, transient concentration and separation were done continuously and controlled by a sequential voltage switching program, time-consuming steps and complicated chip design were not required. Peak resolution between DNA-aptamer and its thrombin complex was influenced by this novel pseudo-terminating electrolyte buffer, which was prepared by the addition of chemical component with slow mobility into the same buffer as leading electrolyte buffer. 1100-fold signal enhancement of thrombin complex was achieved by this transient isotachophoresis on a standard cross-form microchip. The concentration effect or standing time of transient isotachophoresis was proved to be influenced by the concentration of leading electrolyte ion and the concentration of pseudo-terminating electrolyte buffer ion (glycine). The transient concentration was followed by on-chip nondenaturing gel electrophoresis in methylcellulose solution for the size-based separation. The detection limit, taken as the lowest thrombin concentration at threefold S/N, was determined to be 0.5 amol in mass by this method. This journal is © The Royal Society of Chemistry 2011

  15. Transient increase in systemic interferences in the superficial layer and its influence on event-related motor tasks: a functional near-infrared spectroscopy study

    NASA Astrophysics Data System (ADS)

    Nambu, Isao; Ozawa, Takuya; Sato, Takanori; Aihara, Takatsugu; Fujiwara, Yusuke; Otaka, Yohei; Osu, Rieko; Izawa, Jun; Wada, Yasuhiro

    2017-03-01

    Functional near-infrared spectroscopy (fNIRS) is a widely utilized neuroimaging tool in fundamental neuroscience research and clinical investigation. Previous research has revealed that task-evoked systemic artifacts mainly originating from the superficial-tissue may preclude the identification of cerebral activation during a given task. We examined the influence of such artifacts on event-related brain activity during a brisk squeezing movement. We estimated task-evoked superficial-tissue hemodynamics from short source-detector distance channels (15 mm) by applying principal component analysis. The estimated superficial-tissue hemodynamics exhibited temporal profiles similar to the canonical cerebral hemodynamic model. Importantly, this task-evoked profile was also observed in data from a block design motor experiment, suggesting a transient increase in superficial-tissue hemodynamics occurs following motor behavior, irrespective of task design. We also confirmed that estimation of event-related cerebral hemodynamics was improved by a simple superficial-tissue hemodynamic artifact removal process using 15-mm short distance channels, compared to the results when no artifact removal was applied. Thus, our results elucidate task design-independent characteristics of superficial-tissue hemodynamics and highlight the need for the application of superficial-tissue hemodynamic artifact removal methods when analyzing fNIRS data obtained during event-related motor tasks.

  16. Peclet number as affected by molecular diffusion controls transient anomalous transport in alluvial aquifer-aquitard complexes.

    PubMed

    Zhang, Yong; Green, Christopher T; Tick, Geoffrey R

    2015-01-01

    This study evaluates the role of the Peclet number as affected by molecular diffusion in transient anomalous transport, which is one of the major knowledge gaps in anomalous transport, by combining Monte Carlo simulations and stochastic model analysis. Two alluvial settings containing either short- or long-connected hydrofacies are generated and used as media for flow and transport modeling. Numerical experiments show that 1) the Peclet number affects both the duration of the power-law segment of tracer breakthrough curves (BTCs) and the transition rate from anomalous to Fickian transport by determining the solute residence time for a given low-permeability layer, 2) mechanical dispersion has a limited contribution to the anomalous characteristics of late-time transport as compared to molecular diffusion due to an almost negligible velocity in floodplain deposits, and 3) the initial source dimensions only enhance the power-law tail of the BTCs at short travel distances. A tempered stable stochastic (TSS) model is then applied to analyze the modeled transport. Applications show that the time-nonlocal parameters in the TSS model relate to the Peclet number, Pe. In particular, the truncation parameter in the TSS model increases nonlinearly with a decrease in Pe due to the decrease of the mean residence time, and the capacity coefficient increases with an increase in molecular diffusion which is probably due to the increase in the number of immobile particles. The above numerical experiments and stochastic analysis therefore reveal that the Peclet number as affected by molecular diffusion controls transient anomalous transport in alluvial aquifer-aquitard complexes.

  17. Peclet number as affected by molecular diffusion controls transient anomalous transport in alluvial aquifer-aquitard complexes

    USGS Publications Warehouse

    Zhang, Yong; Green, Christopher T.; Tick, Geoffrey R.

    2015-01-01

    This study evaluates the role of the Peclet number as affected by molecular diffusion in transient anomalous transport, which is one of the major knowledge gaps in anomalous transport, by combining Monte Carlo simulations and stochastic model analysis. Two alluvial settings containing either short- or long-connected hydrofacies are generated and used as media for flow and transport modeling. Numerical experiments show that 1) the Peclet number affects both the duration of the power-law segment of tracer breakthrough curves (BTCs) and the transition rate from anomalous to Fickian transport by determining the solute residence time for a given low-permeability layer, 2) mechanical dispersion has a limited contribution to the anomalous characteristics of late-time transport as compared to molecular diffusion due to an almost negligible velocity in floodplain deposits, and 3) the initial source dimensions only enhance the power-law tail of the BTCs at short travel distances. A tempered stable stochastic (TSS) model is then applied to analyze the modeled transport. Applications show that the time-nonlocal parameters in the TSS model relate to the Peclet number, Pe. In particular, the truncation parameter in the TSS model increases nonlinearly with a decrease in Pe due to the decrease of the mean residence time, and the capacity coefficient increases with an increase in molecular diffusion which is probably due to the increase in the number of immobile particles. The above numerical experiments and stochastic analysis therefore reveal that the Peclet number as affected by molecular diffusion controls transient anomalous transport in alluvial aquifer–aquitard complexes.

  18. Thromboembolic Events After Vitamin K Antagonist Reversal With 4-Factor Prothrombin Complex Concentrate: Exploratory Analyses of Two Randomized, Plasma-Controlled Studies.

    PubMed

    Milling, Truman J; Refaai, Majed A; Goldstein, Joshua N; Schneider, Astrid; Omert, Laurel; Harman, Amy; Lee, Martin L; Sarode, Ravi

    2016-01-01

    We evaluated thromboembolic events after vitamin K antagonist reversal in post hoc analyses of pooled data from 2 randomized trials comparing 4-factor prothrombin complex concentrate (4F-PCC) (Beriplex/Kcentra) with plasma. Unblinded investigators identified thromboembolic events, using standardized terms (such as "myocardial infarction," "deep vein thrombosis," "pulmonary embolism," and "ischemic stroke"). A blinded safety adjudication board reviewed serious thromboembolic events, as well as those referred by an independent unblinded data and safety monitoring board. We descriptively compared thromboembolic event and patient characteristics between treatment groups and included detailed patient-level outcome descriptions. We did not power the trials to assess safety. We enrolled 388 patients (4F-PCC: n=191; plasma: n=197) in the trials. Thromboembolic events occurred in 14 of 191 patients (7.3%) in the 4F-PCC group and 14 of 197 (7.1%) in the plasma group (risk difference 0.2%; 95% confidence interval -5.5% to 6.0%). Investigators reported serious thromboembolic events in 16 patients (4F-PCC: n=8; plasma: n=8); the data and safety monitoring board referred 2 additional myocardial ischemia events (plasma group) to the safety adjudication board for review. The safety adjudication board judged serious thromboembolic events in 10 patients (4F-PCC: n=4; plasma: n=6) as possibly treatment related. There were 8 vascular thromboembolic events in the 4F-PCC group versus 4 in the plasma group, and 1 versus 6 cardiac events, respectively. Among patients with thromboembolic events, 3 deaths occurred in each treatment group. All-cause mortality for the pooled population was 13 per group. We observed no relationship between thromboembolic event occurrence and factor levels transiently above the upper limit of normal; there were no notable differences in median factor or proteins C and S levels up to 24 hours postinfusion start in patients with and without thromboembolic events

  19. Complex Event Processing for Content-Based Text, Image, and Video Retrieval

    DTIC Science & Technology

    2016-06-01

    Sensemaking 13 3. Research Gaps 15 4. Promising Methods 16 4.1 Deep Learning 16 4.2 Common Framework for Multimedia Analytics Development and Testing 19...current status of theoretical and practical developments of methods, tools, and techniques supporting joint exploitation of multimedia data sources. In...that are most pertinent to our overall aim of enhancing the contextual understanding of complex events through CBA of heterogeneous multimedia streams

  20. Event-triggered asynchronous intermittent communication strategy for synchronization in complex dynamical networks.

    PubMed

    Li, Huaqing; Liao, Xiaofeng; Chen, Guo; Hill, David J; Dong, Zhaoyang; Huang, Tingwen

    2015-06-01

    This paper presents a new framework for synchronization of complex network by introducing a mechanism of event-triggering distributed sampling information. A kind of event which avoids continuous communication between neighboring nodes is designed to drive the controller update of each node. The advantage of the event-triggering strategy is the significant decrease of the number of controller updates for synchronization task of complex networks involving embedded microprocessors with limited on-board resources. To describe the system's ability reaching synchronization, a concept about generalized algebraic connectivity is introduced for strongly connected networks and then extended to the strongly connected components of the directed network containing a directed spanning tree. Two sufficient conditions are presented to reveal the underlying relationships of corresponding parameters to reach global synchronization based on algebraic graph, matrix theory and Lyapunov control method. A positive lower bound for inter-event times is derived to guarantee the absence of Zeno behavior. Finally, a numerical simulation example is provided to demonstrate the theoretical results.

  1. Improving solar wind persistence forecasts: Removing transient space weather events, and using observations away from the Sun-Earth line

    NASA Astrophysics Data System (ADS)

    Kohutova, Petra; Bocquet, François-Xavier; Henley, Edmund M.; Owens, Matthew J.

    2016-10-01

    This study demonstrates two significant ways of improving persistence forecasts of the solar wind, which exploit the relatively unchanging nature of the ambient solar wind to provide 27 day forecasts, when using data from the Lagrangian L1 point. Such forecasts are useful as a prediction tool for the ambient wind, and for benchmarking of solar wind models. We show that solar wind persistence forecasts can be improved by removing transient solar wind features such as coronal mass ejections (CMEs). Using CME indicators to automatically identify CME-contaminated periods in ACE data from 1998 to 2011, and replacing these with solar wind from a previous synodic rotation, persistence forecasts improve (relative to a baseline): skill scores for Bz, a crucial parameter for determining solar wind geoeffectiveness, improve by 7.7 percentage points when using a proton temperature-based indicator with good operational potential. We also show that persistence forecasts can be improved by using measurements away from L1, to reduce the requirement on coronal stability for an entire synodic period, at the cost of reduced lead time. Using STEREO-B data from 2007 to 2013 to create such a reduced lead time persistence forecast, we show that Bz skill scores improve by 17.1 percentage points relative to ACE. Finally, we report on implications for persistence forecasts from any future missions to the L5 Lagrangian point and on the successful operational implementation (in spring 2015) of the normal (ACE-based) and reduced lead time (STEREO-based) persistence forecasts in the Met Office's Space Weather Operations Centre, as well as plans for future improvements.

  2. Computed tomography imaging spectrometer (CTIS) with 2D reflective grating for ultraviolet to long-wave infrared detection especially useful for surveying transient events

    NASA Technical Reports Server (NTRS)

    Wilson, Daniel W. (Inventor); Maker, Paul D. (Inventor); Muller, Richard E. (Inventor); Mouroulis, Pantazis Z. (Inventor)

    2003-01-01

    The optical system of this invention is an unique type of imaging spectrometer, i.e. an instrument that can determine the spectra of all points in a two-dimensional scene. The general type of imaging spectrometer under which this invention falls has been termed a computed-tomography imaging spectrometer (CTIS). CTIS's have the ability to perform spectral imaging of scenes containing rapidly moving objects or evolving features, hereafter referred to as transient scenes. This invention, a reflective CTIS with an unique two-dimensional reflective grating, can operate in any wavelength band from the ultraviolet through long-wave infrared. Although this spectrometer is especially useful for rapidly occurring events it is also useful for investigation of some slow moving phenomena as in the life sciences.

  3. Computed Tomography Imaging Spectrometer (CTIS) with 2D Reflective Grating for Ultraviolet to Long-Wave Infrared Detection Especially Useful for Surveying Transient Events

    NASA Technical Reports Server (NTRS)

    Wilson, Daniel W. (Inventor); Maker, Paul D. (Inventor); Muller, Richard E. (Inventor); Mouroulis, Pantazis Z. (Inventor)

    2003-01-01

    The optical system of this invention is an unique type of imaging spectrometer, i.e. an instrument that can determine the spectra of all points in a two-dimensional scene. The general type of imaging spectrometer under which this invention falls has been termed a computed-tomography imaging spectrometer (CTIS). CTIS's have the ability to perform spectral imaging of scenes containing rapidly moving objects or evolving features, hereafter referred to as transient scenes. This invention, a reflective CTIS with an unique two-dimensional reflective grating, can operate in any wavelength band from the ultraviolet through long-wave infrared. Although this spectrometer is especially useful for events it is also for investigation of some slow moving phenomena as in the life sciences.

  4. Transient attenuation of the amplitude of the QRS complexes in the diagnosis of Takotsubo syndrome.

    PubMed

    Madias, John E

    2014-03-01

    Currently, there are no specific diagnostic electrocardiogram (ECG) signs for Takotsubo syndrome (TTS) to differentiate it from acute coronary syndromes (ACS). Myocardial oedema has been detected by cardiac magnetic resonance imaging in patients with TTS. Recently it has been postulated that myocardial oedema may be the cause of low QRS voltage (LQRSV) in the admission ECG and attenuation of the amplitude of the QRS complexes (AAQRS) in serial ECGs, noted in a few published cases of patients with TTS. The objective of this study was to evaluate whether the admission ECG of patients with documented TTS reveals LQRSV and whether AAQRS is found when serial ECGs are compared in such patients. This study evaluated the prevalence of LQRSV in the admission ECG and AAQRS in serial ECGs in patients with TTS. ECGs of 368 patients with TTS from published reports in the international literature were evaluated for LQRSV (≤5 mm in limb leads and/or ≤10 mm in precordial leads) and AAQRS in serial ECGs. LQRSV was seen in 91.5% of 200 patients with TTS and one ECG, with a distribution of 49.0, 42.8, 51.0, 52.0, and 46.9%, in lead aVR, and inferior, anterior, lateral, and high lateral ECG lead groups, respectively. AAQRS was seen in 93.5% of 168 patients with TTS and two or more ECGs, with a distribution of 78.3, 74.5, 60.1, 70.7, and 74.5% in lead aVR, and inferior, anterior, lateral, and high lateral ECG lead groups, respectively. LQRSV and AAQRS are highly prevalent ECG signs in patients with TTS, and should be useful in aiding in its diagnosis and differentiation from ACS, on first contact with the patient on admission to the hospital, and the ensuing 24 hours, in conjunction with echocardiography and coronary arteriography.

  5. Transient attenuation of the amplitude of the QRS complexes in the diagnosis of Takotsubo syndrome

    PubMed Central

    2014-01-01

    Background and objectives: Currently, there are no specific diagnostic electrocardiogram (ECG) signs for Takotsubo syndrome (TTS) to differentiate it from acute coronary syndromes (ACS). Myocardial oedema has been detected by cardiac magnetic resonance imaging in patients with TTS. Recently it has been postulated that myocardial oedema may be the cause of low QRS voltage (LQRSV) in the admission ECG and attenuation of the amplitude of the QRS complexes (AAQRS) in serial ECGs, noted in a few published cases of patients with TTS. The objective of this study was to evaluate whether the admission ECG of patients with documented TTS reveals LQRSV and whether AAQRS is found when serial ECGs are compared in such patients. Methods: This study evaluated the prevalence of LQRSV in the admission ECG and AAQRS in serial ECGs in patients with TTS. ECGs of 368 patients with TTS from published reports in the international literature were evaluated for LQRSV (≤5 mm in limb leads and/or ≤10 mm in precordial leads) and AAQRS in serial ECGs. Results: LQRSV was seen in 91.5% of 200 patients with TTS and one ECG, with a distribution of 49.0, 42.8, 51.0, 52.0, and 46.9%, in lead aVR, and inferior, anterior, lateral, and high lateral ECG lead groups, respectively. AAQRS was seen in 93.5% of 168 patients with TTS and two or more ECGs, with a distribution of 78.3, 74.5, 60.1, 70.7, and 74.5% in lead aVR, and inferior, anterior, lateral, and high lateral ECG lead groups, respectively. Conclusions: LQRSV and AAQRS are highly prevalent ECG signs in patients with TTS, and should be useful in aiding in its diagnosis and differentiation from ACS, on first contact with the patient on admission to the hospital, and the ensuing 24 hours, in conjunction with echocardiography and coronary arteriography. PMID:24562801

  6. Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in patients with stroke or transient ischaemic attack.

    PubMed

    Liu, Jia; Wang, Lu-Ning

    2015-10-29

    Peroxisome proliferator-activated receptor gamma (PPAR-γ) agonists are insulin-sensitising drugs used for the treatment of insulin resistance. In addition to lowering glucose in diabetes, these drugs may also protect against hyperlipidaemia and arteriosclerosis, which are risk factors for stroke. To assess the efficacy and safety of PPAR-γ agonists in the secondary prevention of stroke and related vascular events for people with stroke or transient ischaemic attack (TIA). We searched the Cochrane Stroke Group Trials Register (July 2015), the Cochrane Central Register of Controlled Trials (CENTRAL 2015, Issue 6), MEDLINE (1949 to July 2015), EMBASE (1980 to July 2015), CINAHL (1982 to July 2015), AMED (1985 to July 2015) and 11 Chinese databases (July 2015). In an effort to identify further published, unpublished and ongoing trials we searched ongoing trials registers, reference lists and relevant conference proceedings, and contacted authors and pharmaceutical companies. We did not impose any language restrictions. We included randomised controlled trials (RCTs) evaluating PPAR-γ agonists versus placebo for the secondary prevention of stroke and related vascular events in people with stroke or TIA, with the outcomes of recurrent stroke, vascular events and adverse events. Two review authors independently screened the titles and abstracts of identified records, selected studies for inclusion, extracted eligible data, cross-checked the data for accuracy, and assessed methodological quality and risk of bias. We identified four eligible studies with 1163 participants; only one study had a low risk of bias for all domains. Three studies evaluated the drug pioglitazone and one study evaluated rosiglitazone. The participants in different studies were heterogeneous. The number of participants with recurrent stroke was evaluated in two studies, where PPAR-γ agonists reduced the recurrence of stroke compared with placebo (risk ratio (RR) 0.52, 95% confidence interval (CI

  7. Self-Structures, Negative Events, and Adolescent Depression: Clarifying the Role of Self-Complexity in a Prospective, Multiwave Study

    ERIC Educational Resources Information Center

    Cohen, Joseph R.; Spiegler, Kevin M.; Young, Jami F.; Hankin, Benjamin L.; Abela, John R. Z.

    2014-01-01

    The purpose of this multiwave longitudinal study was to examine the structure of self-complexity and its relation to depressive symptoms in 276 adolescents (M = 12.55; SD = 1.04). Self-complexity, depressive symptoms, and negative events were assessed during a laboratory assessment at baseline, and then depressive symptoms and negative events were…

  8. The complex Young's modulus of skeletal muscle fibre segments in the high frequency range determined from tension transients.

    PubMed

    De Winkel, M E; Blangé, T; Treijtel, B W

    1993-06-01

    Stiffness measurements of muscle fibres are often based on application of a length change at one end of the muscle fibre and recording of the following tension change at the other end. In this study a method is developed to determine in the high frequency range (up to 40 kHz) the complex Young's modulus of skeletal muscle fibre as a function of frequency from the tension transient, following a rapid stepwise length change completed within 40 microseconds. For this purpose both a new mechanical moving part of the displacement generating system and a force transducer with a high natural frequency (70 kHz) had to be developed. In addition to stiffness measurements of a silk fibre to test the displacement generating system and the method of analysis, stiffness of skeletal muscle fibres in relaxed and rigor state have been measured. The complex Young's moduli of relaxed muscle fibres as well as muscle fibres in rigor state are frequency dependent. In both cases the complex Young's modulus increases smoothly with increasing frequency over a range of 250 Hz up to 40 kHz. The phase angles of the responses remained almost constant at a value of 0.3 radians for a fibre in rigor and 0.6 radians for a relaxed fibre. This leads to the conclusion that for muscle fibres in rigor state the recovery in the tension response to a step length change shows a continuous distribution of relaxation times rather than a few discrete ones. Results of our stiffness measurements are compared with results obtained from current viscoelastic models used to describe stiffness of muscle fibre in this frequency range.(ABSTRACT TRUNCATED AT 250 WORDS)

  9. Hydrogen-poor Superluminous Supernovae with Late-time Hα Emission: Three Events From the Intermediate Palomar Transient Factory

    NASA Astrophysics Data System (ADS)

    Yan, Lin; Lunnan, R.; Perley, D. A.; Gal-Yam, A.; Yaron, O.; Roy, R.; Quimby, R.; Sollerman, J.; Fremling, C.; Leloudas, G.; Cenko, S. B.; Vreeswijk, P.; Graham, M. L.; Howell, D. A.; De Cia, A.; Ofek, E. O.; Nugent, P.; Kulkarni, S. R.; Hosseinzadeh, G.; Masci, F.; McCully, C.; Rebbapragada, U. D.; Woźniak, P.

    2017-10-01

    We present observations of two new hydrogen-poor superluminous supernovae (SLSN-I), iPTF15esb and iPTF16bad, showing late-time Hα emission with line luminosities of (1{--}3)× {10}41 erg s‑1 and velocity widths of (4000–6000) km s‑1. Including the previously published iPTF13ehe, this makes up a total of three such events to date. iPTF13ehe is one of the most luminous and the slowest evolving SLSNe-I, whereas the other two are less luminous and fast decliners. We interpret this as a result of the ejecta running into a neutral H-shell located at a radius of ∼1016 cm. This implies that violent mass loss must have occurred several decades before the supernova explosion. Such a short time interval suggests that eruptive mass loss could be common shortly before core collapse, and more importantly helium is unlikely to be completely stripped off the progenitor and could be present in the ejecta. It is a mystery why helium features are not detected, even though nonthermal energy sources, capable of ionizing He, may exist as suggested by the O ii absorption series in the early-time spectra. Our late-time spectra (+240 days) appear to have intrinsically lower [O i] 6300 Å luminosities than that of SN2015bn and SN2007bi, which is possibly an indication of less oxygen (<10 M ⊙). The blueshifted Hα emission relative to the hosts for all three events may be in tension with the binary model proposed for iPTF13ehe. Finally, iPTF15esb has a peculiar light curve (LC) with three peaks separated from one another by ∼22 days. The LC undulation is stronger in bluer bands. One possible explanation is ejecta-circumstellar medium interaction.

  10. Spectral signatures of penumbral transients

    SciTech Connect

    Reardon, K.; Tritschler, A.

    2013-12-20

    In this work we investigate the properties of penumbral transients observed in the upper photospheric and chromospheric region above a sunspot penumbra using two-dimensional spectroscopic observations of the Ca II 854.21 nm line with a 5 s cadence. In our 30 minutes of observations, we identify several penumbral-micro jets (PMJs) with cotemporal observations from Dunn Solar Telescope/IBIS and Hinode/SOT. We find that the line profiles of these PMJ events show emission in the two wings of the line (±0.05 nm), but little modification of the line core. These are reminiscent of the line profiles of Ellerman bombs observed in plage and network regions. Furthermore, we find evidence that some PMJ events have a precursor phase starting 1 minute prior to the main brightening that might indicate initial heating of the plasma prior to an acoustic or bow shock event. With the IBIS data, we also find several other types of transient brightenings with timescales of less than 1 minute that are not clearly seen in the Hinode/SOT data. The spectral profiles and other characteristics of these events are significantly different from those of PMJs. The different appearances of all these transients are an indicator of the general complexity of the chromospheric magnetic field and underscore the highly dynamic behavior above sunspots. It also highlights the care that is needed in interpreting broadband filter images of chromospheric lines, which may conceal very different spectral profiles, and the underlying physical mechanisms at work.

  11. Towards Hybrid Online On-Demand Querying of Realtime Data with Stateful Complex Event Processing

    SciTech Connect

    Zhou, Qunzhi; Simmhan, Yogesh; Prasanna, Viktor K.

    2013-10-09

    Emerging Big Data applications in areas like e-commerce and energy industry require both online and on-demand queries to be performed over vast and fast data arriving as streams. These present novel challenges to Big Data management systems. Complex Event Processing (CEP) is recognized as a high performance online query scheme which in particular deals with the velocity aspect of the 3-V’s of Big Data. However, traditional CEP systems do not consider data variety and lack the capability to embed ad hoc queries over the volume of data streams. In this paper, we propose H2O, a stateful complex event processing framework, to support hybrid online and on-demand queries over realtime data. We propose a semantically enriched event and query model to address data variety. A formal query algebra is developed to precisely capture the stateful and containment semantics of online and on-demand queries. We describe techniques to achieve the interactive query processing over realtime data featured by efficient online querying, dynamic stream data persistence and on-demand access. The system architecture is presented and the current implementation status reported.

  12. Comparative research on “high currents” induced by single event latch-up and transient-induced latch-up

    NASA Astrophysics Data System (ADS)

    Chen, Rui; Han, Jian-Wei; Zheng, Han-Sheng; Yu, Yong-Tao; Shangguang, Shi-Peng; Feng, Guo-Qiang; Ma, Ying-Qi

    2015-04-01

    By using the pulsed laser single event effect facility and electro-static discharge (ESD) test system, the characteristics of the “high current”, relation with external stimulus and relevance to impacted modes of single event latch-up (SEL) and transient-induced latch-up (TLU) are studied, respectively, for a 12-bit complementary metal-oxide semiconductor (CMOS) analog-to-digital converter. Furthermore, the sameness and difference in physical mechanism between “high current” induced by SEL and that by TLU are disclosed in this paper. The results show that the minority carrier diffusion in the PNPN structure of the CMOS device which initiates the active parasitic NPN and PNP transistors is the common reason for the “high current” induced by SEL and for that by TLU. However, for SEL, the minority carrier diffusion is induced by the ionizing radiation, and an underdamped sinusoidal voltage on the supply node (the ground node) is the cause of the minority carrier diffusion for TLU. Project supported by the National Natural Science Foundation of China (Grant No. 41304148).

  13. The background rate of false positives: Combining simulations of gravitational wave events with an unsupervised algorithm for transient identification in crowded image-subtracted data

    NASA Astrophysics Data System (ADS)

    Ackley, Kendall; Eikenberry, Stephen; Klimenko, Sergey; LIGO Collaboration

    2016-03-01

    We are now entering the era of multimessenger gravitational wave (GW) astronomy with the completion of the first observing run of Advanced LIGO. Multiwavelength electromagnetic (EM) emission is expected to accompany gravitational radiation from compact object binary mergers, such as those between neutron stars and stellar-mass black holes, where Advanced LIGO is most sensitive to their detection. Attempting to perform EM follow-up over the 10-100s deg2 error regions will be faced with many challenges, including the identification and removal of O (105) false positive transients that appear as a commotion of background events and as image artifacts in crowded image-subtracted fields. We present an update to our automated unsupervised algorithm including how our pipeline uses the existing coherent WaveBurst pipeline in an attempt to develop optimized EM follow-up schema. Our end-to-end pipeline combines simulated GW events with actual observational data from a number of ground-based optical observatories, including PTF, ROTSE, and DECam. Our performance is reported both in terms of the number of coincident false positives as well as the efficiency of recovery.

  14. Infrared Imaging of Transient Luminous Events (1-1.5 microns) Over the Mid-Western US and Comparison with their Visible Wavelength Signatures

    NASA Astrophysics Data System (ADS)

    Bailey, Matt; Taylor, Michael J.; Pautet, Dominique; Lyons, Walter A.; Cummer, Steven

    2006-10-01

    As part of a coordinated campaign conducted from Yucca Ridge, Colorado during summer, 2005, four sensitive imaging systems were fielded by Utah State University to investigate the signatures of transient luminous events (TLE's) over a broad spectral range, extending from the near ultra violet (0.35 microns) to infrared wavelengths (1.5 microns). These measurements were made in conjunction with high speed video and electromagnetic observations providing detailed information of the TLE dynamics and their structures. The USU instruments consisted of two Gen 3 Xybion cameras, one filtered to observe N2 first positive emissions (665 nm) while the second observed white light emissions. A third intensified camera with an extended blue response was fitted with a broad band filter to observe the N2^+ first negative and N2 second positive emissions (band width, 350-475 nm). Novel infrared measurements were made using an InGaAs imaging array operating at video rates. All four cameras had similar fields of view (25^o) and were co-aligned on a single mount with the high speed imager. We discovered that sprites were easily imaged in the infrared spectral range, and over 30 events were captured with the InGaAs camera arising from thunderstorms over the mid-western United States during early July and mid August. This poster presents new measurements of the optical characteristics of TLEs imaged in the infrared spectral range (1-1.5 microns) and an initial comparison with their visible and near UV signatures.

  15. X-ray structures of the three Lactococcus lactis dihydroxyacetone kinase subunits and of a transient intersubunit complex.

    PubMed

    Zurbriggen, Andreas; Jeckelmann, Jean-Marc; Christen, Sandra; Bieniossek, Christoph; Baumann, Ulrich; Erni, Bernhard

    2008-12-19

    Bacterial dihydroxyacetone (Dha) kinases do not exchange the ADP for ATP but utilize a subunit of the phosphoenolpyruvate carbohydrate phosphotransferase system for in situ rephosphorylation of a permanently bound ADP-cofactor. Here we report the 2.1-angstroms crystal structure of the transient complex between the phosphotransferase subunit DhaM of the phosphotransferase system and the nucleotide binding subunit DhaL of the Dha kinase of Lactococcus lactis, the 1.1-angstroms structure of the free DhaM dimer, and the 2.5-angstroms structure of the Dha-binding DhaK subunit. Conserved salt bridges and an edge-to-plane stacking contact between two tyrosines serve to orient DhaL relative to the DhaM dimer. The distance between the imidazole Nepsilon2 of the DhaM His-10 and the beta-phosphate oxygen of ADP, between which the gamma-phosphate is transferred, is 4.9 angstroms. An invariant arginine, which is essential for activity, is appropriately positioned to stabilize the gamma-phosphate in the transition state. The (betaalpha)4alpha fold of DhaM occurs a second time as a subfold in the DhaK subunit. By docking DhaL-ADP to this subfold, the nucleotide bound to DhaL and the C1-hydroxyl of Dha bound to DhaK are positioned for in-line transfer of phosphate.

  16. Complex Events Initiated by Individual Spikes in the Human Cerebral Cortex

    PubMed Central

    Komlósi, Gergely; Füle, Miklós; Szabadics, János; Varga, Csaba; Barzó, Pál; Tamás, Gábor

    2008-01-01

    Synaptic interactions between neurons of the human cerebral cortex were not directly studied to date. We recorded the first dataset, to our knowledge, on the synaptic effect of identified human pyramidal cells on various types of postsynaptic neurons and reveal complex events triggered by individual action potentials in the human neocortical network. Brain slices were prepared from nonpathological samples of cortex that had to be removed for the surgical treatment of brain areas beneath association cortices of 58 patients aged 18 to 73 y. Simultaneous triple and quadruple whole-cell patch clamp recordings were performed testing mono- and polysynaptic potentials in target neurons following a single action potential fired by layer 2/3 pyramidal cells, and the temporal structure of events and underlying mechanisms were analyzed. In addition to monosynaptic postsynaptic potentials, individual action potentials in presynaptic pyramidal cells initiated long-lasting (37 ± 17 ms) sequences of events in the network lasting an order of magnitude longer than detected previously in other species. These event series were composed of specifically alternating glutamatergic and GABAergic postsynaptic potentials and required selective spike-to-spike coupling from pyramidal cells to GABAergic interneurons producing concomitant inhibitory as well as excitatory feed-forward action of GABA. Single action potentials of human neurons are sufficient to recruit Hebbian-like neuronal assemblies that are proposed to participate in cognitive processes. PMID:18767905

  17. Anamorsin/Ndor1 Complex Reduces [2Fe-2S]-MitoNEET via a Transient Protein-Protein Interaction.

    PubMed

    Camponeschi, Francesca; Ciofi-Baffoni, Simone; Banci, Lucia

    2017-07-19

    Human mitoNEET is a homodimeric protein anchored to the outer mitochondrial membrane and has a C-terminal [2Fe-2S] binding domain located in the cytosol. Recently, human mitoNEET has been shown to be implicated in Fe/S cluster repair of cytosolic iron regulatory protein 1 (IRP1), a key regulator of cellular iron homeostasis in mammalian cells. The Fe/S cluster repair function of mitoNEET is based on an Fe/S redox switch mechanism: under normal cellular conditions, reduced [2Fe-2S](+)-mitoNEET is present and is inactive as an Fe/S cluster transfer protein; under conditions of oxidative cellular stress, the clusters of mitoNEET become oxidized, and the formed [2Fe-2S](2+)-mitoNEET species reacts promptly to initiate Fe/S cluster transfer to IRP1, recycling the cytosolic apo-IRP1 into holo-aconitase. Until now, no clear data have been available on which is the system that reduces the mitoNEET clusters back once oxidative stress is not present anymore. In the present work, we used UV-vis and NMR spectroscopies to investigate the electron transfer process between mitoNEET and the cytosolic electron-donor Ndor1/anamorsin complex, a component of the cytosolic iron-sulfur protein assembly (CIA) machinery. The [2Fe-2S] clusters of mitoNEET are reduced via the formation of a transient complex that brings the [2Fe-2S] clusters of mitoNEET close to the redox-active [2Fe-2S] cluster of anamorsin. Our data provide in vitro evidence of a possible direct link between the CIA machinery and the mitoNEET cluster transfer repair pathway. This link might contribute to recovery of CIA machinery efficiency to mature cytosolic and nuclear Fe/S proteins.

  18. Prenatal complex rhythmic music sound stimulation facilitates postnatal spatial learning but transiently impairs memory in the domestic chick.

    PubMed

    Kauser, H; Roy, S; Pal, A; Sreenivas, V; Mathur, R; Wadhwa, S; Jain, S

    2011-01-01

    Early experience has a profound influence on brain development, and the modulation of prenatal perceptual learning by external environmental stimuli has been shown in birds, rodents and mammals. In the present study, the effect of prenatal complex rhythmic music sound stimulation on postnatal spatial learning, memory and isolation stress was observed. Auditory stimulation with either music or species-specific sounds or no stimulation (control) was provided to separate sets of fertilized eggs from day 10 of incubation. Following hatching, the chicks at age 24, 72 and 120 h were tested on a T-maze for spatial learning and the memory of the learnt task was assessed 24 h after training. In the posthatch chicks at all ages, the plasma corticosterone levels were estimated following 10 min of isolation. The chicks of all ages in the three groups took less (p < 0.001) time to navigate the maze over the three trials thereby showing an improvement with training. In both sound-stimulated groups, the total time taken to reach the target decreased significantly (p < 0.01) in comparison to the unstimulated control group, indicating the facilitation of spatial learning. However, this decline was more at 24 h than at later posthatch ages. When tested for memory after 24 h of training, only the music-stimulated chicks at posthatch age 24 h took a significantly longer (p < 0.001) time to traverse the maze, suggesting a temporary impairment in their retention of the learnt task. In both sound-stimulated groups at 24 h, the plasma corticosterone levels were significantly decreased (p < 0.001) and increased thereafter at 72 h (p < 0.001) and 120 h which may contribute to the differential response in spatial learning. Thus, prenatal auditory stimulation with either species-specific or complex rhythmic music sounds facilitates spatial learning, though the music stimulation transiently impairs postnatal memory. 2011 S. Karger AG, Basel.

  19. Reactions of Highly Uniform Zeolite H-Supported Rhodium Complexes: Transient Characterization by Infrared and X-ray Absorption Spectroscopies

    SciTech Connect

    Ogino, I.; Gates, B

    2010-01-01

    A zeolite H-{beta}-supported mononuclear rhodium diethene complex (Rh(C{sub 2}H{sub 4}){sub 2}{l_brace}O{sub 2}Al{r_brace}, where the braces indicate a part of the zeolite) was formed by the reaction of Rh(acac)({eta}{sub 2}-C{sub 2}H{sub 4}){sub 2} (acac = acetylacetonate, C{sub 5}H{sub 7}O{sub 2}{sup -}) with the zeolite. Transient characterization of the sample by X-ray absorption near edge structure (XANES) and infrared (IR) spectroscopies (combined with mass spectrometry of the effluent gas) while the sample was in contact with flowing CO indicates a simple stoichiometric conversion of the supported metal complex into another species, identified by the spectra as the zeolite-supported rhodium gem-dicarbonyl (Rh(CO){sub 2}{l_brace}O{sub 2}Al{r_brace}). The sharpness of the v{sub CO} bands in the IR spectrum indicates a high degree of uniformity of the supported rhodium gem-dicarbonyl, and isosbestic points in the XANES spectra as the transformation was occurring imply that the rhodium diethene complex was also highly uniform. Spectra similarly show that treatment of the supported rhodium gem-dicarbonyl with flowing C{sub 2}H{sub 4} resulted in another stoichiometrically simple transformation, giving a species suggested to be Rh(C{sub 2}H{sub 4})(CO){sub 2}{l_brace}O{sub 2}Al{r_brace}. The intermediate was ultimately transformed when the sample was purged with helium into another highly uniform supported species, inferred on the basis of IR spectra to be Rh(C{sub 2}H{sub 4})(CO){l_brace}O{sub 2}Al{r_brace}. Extended X-ray absorption fine structure spectra characterizing the supported rhodium diethene complex and the species formed from it show how the Rh-O bond distance at the Rh-support interface varied in response to the changes in the ligands bonded to the rhodium.

  20. Discrete event simulation as a tool in optimization of a professional complex adaptive system.

    PubMed

    Nielsen, Anders Lassen; Hilwig, Helmer; Kissoon, Niranjan; Teelucksingh, Surujpal

    2008-01-01

    Similar urgent needs for improvement of health care systems exist in the developed and developing world. The culture and the organization of an emergency department in developing countries can best be described as a professional complex adaptive system, where each agent (employee) are ignorant of the behavior of the system as a whole; no one understands the entire system. Each agent's action is based on the state of the system at the moment (i.e. lack of medicine, unavailable laboratory investigation, lack of beds and lack of staff in certain functions). An important question is how one can improve the emergency service within the given constraints. The use of simulation signals is one new approach in studying issues amenable to improvement. Discrete event simulation was used to simulate part of the patient flow in an emergency department. A simple model was built using a prototyping approach. The simulation showed that a minor rotation among the nurses could reduce the mean number of visitors that had to be refereed to alternative flows within the hospital from 87 to 37 on a daily basis with a mean utilization of the staff between 95.8% (the nurses) and 87.4% (the doctors). We conclude that even faced with resource constraints and lack of accessible data discrete event simulation is a tool that can be used successfully to study the consequences of changes in very complex and self organizing professional complex adaptive systems.

  1. The complex of SAO RAS optical instruments as an instrument for studying transient sources in the Universe

    NASA Astrophysics Data System (ADS)

    Vlasyuk, V. V.; Sokolov, V. V.

    2016-06-01

    The paper describes the optical telescopes of SAO RAS and available equipment suitable for studying transient sources. The first experience of investigation of one of the fist gamma-ray bursts (GRB 970508) dates back to 1997. The experience accumulated since then in studying transient sources is also described. Future prospects are outlined.

  2. The South American rainfall dipole: A complex network analysis of extreme events

    NASA Astrophysics Data System (ADS)

    Boers, Niklas; Rheinwalt, Aljoscha; Bookhagen, Bodo; Barbosa, Henrique M. J.; Marwan, Norbert; Marengo, José; Kurths, Jürgen

    2014-10-01

    Intraseasonal rainfall variability of the South American monsoon system is characterized by a pronounced dipole between southeastern South America and southeastern Brazil. Here we analyze the dynamical properties of extreme rainfall events associated with this dipole by combining a nonlinear synchronization measure with complex networks. We make the following main observations: (i) Our approach reveals the dominant synchronization pathways of extreme events for the two dipole phases, (ii) while extreme rainfall synchronization in the tropics is directly driven by the trade winds and their deflection by the Andes mountains, extreme rainfall propagation in the subtropics is mainly dictated by frontal systems, and (iii) the well-known rainfall dipole is, in fact, only the most prominent mode of an oscillatory pattern that extends over the entire continent. This provides further evidence that the influence of Rossby waves, which cause frontal systems over South America and impact large-scale circulation patterns, extends beyond the equator.

  3. Very high energy gamma-ray observation of the peculiar transient event Swift J1644+57 with the MAGIC telescopes and AGILE

    NASA Astrophysics Data System (ADS)

    Aleksić, J.; Antonelli, L. A.; Antoranz, P.; Asensio, M.; Backes, M.; Barres de Almeida, U.; Barrio, J. A.; Becerra González, J.; Bednarek, W.; Berger, K.; Bernardini, E.; Biland, A.; Blanch, O.; Bock, R. K.; Boller, A.; Bonnefoy, S.; Bonnoli, G.; Borla Tridon, D.; Bretz, T.; Carmona, E.; Carosi, A.; Carreto Fidalgo, D.; Colin, P.; Colombo, E.; Contreras, J. L.; Cortina, J.; Cossio, L.; Covino, S.; Da Vela, P.; Dazzi, F.; De Angelis, A.; De Caneva, G.; De Lotto, B.; Delgado Mendez, C.; Doert, M.; Domínguez, A.; Dominis Prester, D.; Dorner, D.; Doro, M.; Eisenacher, D.; Elsaesser, D.; Farina, E.; Ferenc, D.; Fonseca, M. V.; Font, L.; Fruck, C.; García López, R. J.; Garczarczyk, M.; Garrido Terrats, D.; Gaug, M.; Giavitto, G.; Godinović, N.; González Muñoz, A.; Gozzini, S. R.; Hadamek, A.; Hadasch, D.; Herrero, A.; Hose, J.; Hrupec, D.; Idec, W.; Jankowski, F.; Kadenius, V.; Klepser, S.; Knoetig, M. L.; Krähenbühl, T.; Krause, J.; Kushida, J.; La Barbera, A.; Lelas, D.; Lewandowska, N.; Lindfors, E.; Lombardi, S.; López, M.; López-Coto, R.; López-Oramas, A.; Lorenz, E.; Lozano, I.; Makariev, M.; Mallot, K.; Maneva, G.; Mankuzhiyil, N.; Mannheim, K.; Maraschi, L.; Marcote, B.; Mariotti, M.; Martínez, M.; Masbou, J.; Mazin, D.; Meucci, M.; Miranda, J. M.; Mirzoyan, R.; Moldón, J.; Moralejo, A.; Munar-Adrover, P.; Nakajima, D.; Niedzwiecki, A.; Nilsson, K.; Nowak, N.; Orito, R.; Paiano, S.; Palatiello, M.; Paneque, D.; Paoletti, R.; Paredes, J. M.; Partini, S.; Persic, M.; Prada, F.; Prada Moroni, P. G.; Prandini, E.; Puljak, I.; Reichardt, I.; Reinthal, R.; Rhode, W.; Ribó, M.; Rico, J.; Saggion, A.; Saito, K.; Saito, T. Y.; Salvati, M.; Satalecka, K.; Scalzotto, V.; Scapin, V.; Schultz, C.; Schweizer, T.; Shore, S. N.; Sillanpää, A.; Sitarek, J.; Snidaric, I.; Sobczynska, D.; Spanier, F.; Spiro, S.; Stamatescu, V.; Stamerra, A.; Steinke, B.; Storz, J.; Sun, S.; Surić, T.; Takalo, L.; Takami, H.; Tavecchio, F.; Temnikov, P.; Terzić, T.; Tescaro, D.; Teshima, M.; Tibolla, O.; Torres, D. F.; Toyama, T.; Treves, A.; Uellenbeck, M.; Vogler, P.; Wagner, R. M.; Weitzel, Q.; Zandanel, F.; Zanin, R.; Longo, F.; Lucarelli, F.; Pittori, C.; Verrecchia, F.

    2013-04-01

    Context. On March 28, 2011, the BAT instrument on board the Swift satellite detected a new transient event that in the very beginning was classified as a gamma ray burst (GRB). However, the unusual X-ray flaring activity observed from a few hours up to days after the onset of the event made a different nature seem to be more likely. The long-lasting activity in the X-ray band, followed by a delayed brightening of the source in infrared and radio activity, suggested that it is better interpreted as a tidal disruption event that triggered a dormant black hole in the nucleus of the host galaxy and generated an outflowing jet of relativistic matter. Aims: Detecting a very high energy emission component from such a peculiar object would be enable us to constrain the dynamic of the emission processes and the jet model by providing information on the Doppler factor of the relativistic ejecta . Methods: The MAGIC telescopes observed the peculiar source Swift J1644+57 during the flaring phase, searching for gamma-ray emission at very-high energy (VHE, E > 100 GeV), starting observations nearly 2.5 days after the trigger time. MAGIC collected a total of 28 h of data during 12 nights. The source was observed in wobble mode during dark time at a mean zenith angle of 35°. Data were reduced using a new image-cleaning algorithm, the so-called sum-cleaning, which guarantees a better noise suppression and a lower energy threshold than the standard analysis procedure. Results: No clear evidence for emission above the energy threshold of 100 GeV was found. MAGIC observations permit one to constrain the emission from the source down to 100 GeV, which favors models that explain the observed lower energy variable emission. Data analysis of simultaneous observations from AGILE, Fermi and VERITAS also provide negative detection, which additionally constrain the self-Compton emission component.

  4. Structured event complexes in the medial prefrontal cortex support counterfactual representations for future planning.

    PubMed

    Barbey, Aron K; Krueger, Frank; Grafman, Jordan

    2009-05-12

    We propose that counterfactual representations for reasoning about the past or predicting the future depend on structured event complexes (SECs) in the human prefrontal cortex (PFC; 'What would happen if X were performed in the past or enacted in the future?'). We identify three major categories of counterfactual thought (concerning action versus inaction, the self versus other and upward versus downward thinking) and propose that each form of inference recruits SEC representations in distinct regions of the medial PFC. We develop a process model of the regulatory functions these representations serve and draw conclusions about the importance of SECs for explaining the past and predicting the future.

  5. Structured event complexes in the medial prefrontal cortex support counterfactual representations for future planning

    PubMed Central

    Barbey, Aron K.; Krueger, Frank; Grafman, Jordan

    2009-01-01

    We propose that counterfactual representations for reasoning about the past or predicting the future depend on structured event complexes (SECs) in the human prefrontal cortex (PFC; ‘What would happen if X were performed in the past or enacted in the future?’). We identify three major categories of counterfactual thought (concerning action versus inaction, the self versus other and upward versus downward thinking) and propose that each form of inference recruits SEC representations in distinct regions of the medial PFC. We develop a process model of the regulatory functions these representations serve and draw conclusions about the importance of SECs for explaining the past and predicting the future. PMID:19528010

  6. Stimulus complexity effects on the event-related potentials to task-irrelevant stimuli.

    PubMed

    Barkaszi, Irén; Czigler, István; Balázs, László

    2013-09-01

    The effects of irrelevant stimuli complexity on event-related potentials were investigated in 3 conditions using both auditory and visual oddball tasks. In Conditions 1 and 2, simple standard and target stimuli were presented in series with complex, identical (Condition 1) or variable (Condition 2), task-irrelevant stimuli. In Condition 3, complex standards and targets were presented with simple, identical, task-irrelevant stimuli. In Conditions 1 and 2, but not Condition 3, the irrelevant stimuli elicited the P3a component in both auditory and visual modalities and the N2b component in the visual modality. While we found that variable, irrelevant stimuli evoked larger P3a in the auditory modality compared with identical irrelevant stimuli, we observed the opposite effect in the visual modality. These results suggest that stimuli rareness and irrelevance are not sufficient for eliciting P3a. This component is only elicited by irrelevant stimuli that are at least as complex as the task-related stimuli. Copyright © 2013 Elsevier B.V. All rights reserved.

  7. Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events.

    PubMed

    Pryor, Paul R; Mullock, Barbara M; Bright, Nicholas A; Lindsay, Margaret R; Gray, Sally R; Richardson, Simon C W; Stewart, Abigail; James, David E; Piper, Robert C; Luzio, J Paul

    2004-06-01

    Both heterotypic and homotypic fusion events are required to deliver endocytosed macromolecules to lysosomes and remodel late endocytic organelles. A trans-SNARE complex consisting of Q-SNAREs syntaxin 7, Vti1b and syntaxin 8 and the R-SNARE VAMP8 has been shown by others to be responsible for homotypic fusion of late endosomes. Using antibody inhibition experiments in rat liver cell-free systems, we confirmed this result, but found that the same Q-SNAREs can combine with an alternative R-SNARE, namely VAMP7, for heterotypic fusion between late endosomes and lysosomes. Co-immunoprecipitation demonstrated separate syntaxin 7 complexes with either VAMP7 or VAMP8 in solubilized rat liver membranes. Additionally, overexpression of the N-terminal domain of VAMP7, in cultured fibroblastic cells, inhibited the mixing of a preloaded lysosomal content marker with a marker delivered to late endosomes. These data show that combinatorial interactions of SNAREs determine whether late endosomes undergo homotypic or heterotypic fusion events.

  8. Complex cardiac defects after ethanol exposure during discrete cardiogenic events in zebrafish: Prevention with folic acid

    PubMed Central

    Sarmah, Swapnalee; Marrs, James A.

    2014-01-01

    BACKGROUND Fetal alcohol spectrum disorder (FASD) describes a range of birth defects including various congenital heart defects (CHDs). Mechanisms of FASD-associated CHDs are not understood. Whether alcohol interferes with a single critical event or with multiple events in heart formation is not known. RESULTS Our zebrafish embryo experiments showed that ethanol interrupts different cardiac regulatory networks and perturbed multiple steps of cardiogenesis (specification, myocardial migration, looping, chamber morphogenesis and endocardial cushion formation). Ethanol exposure during gastrulation until cardiac specification or during myocardial midline migration did not produce severe or persistent heart development defects. However, exposure comprising gastrulation until myocardial precursor midline fusion or during heart patterning stages produced aberrant heart looping and defective endocardial cushions. Continuous exposure during entire cardiogenesis produced complex cardiac defects leading to severely defective myocardium, endocardium, and endocardial cushions. Supplementation of retinoic acid with ethanol partially rescued early heart developmental defects, but the endocardial cushions did not form correctly. In contrast, supplementation of folic acid rescued normal heart development, including the endocardial cushions. CONCLUSIONS Our results indicate that ethanol exposure interrupted divergent cardiac morphogenesis events causing heart defects. Folic acid supplementation was effective in preventing a wide spectrum of ethanol-induced heart developmental defects. PMID:23832875

  9. Event attribution using data assimilation in an intermediate complexity atmospheric model

    NASA Astrophysics Data System (ADS)

    Metref, Sammy; Hannart, Alexis; Ruiz, Juan; Carrassi, Alberto; Bocquet, Marc; Ghil, Michael

    2016-04-01

    A new approach, coined DADA (Data Assimilation for Detection and Attribution) has been recently introduced by Hannart et al. 2015, and is potentially useful for near real time, systematic causal attribution of weather and climate-related events The method is purposely designed to allow its operability at meteorological centers by synergizing causal attribution with Data Assimilation (DA) methods usually designed to deal with large nonlinear models. In Hannart et al. 2015, the DADA proposal is illustrated in the context of a low-order nonlinear model (forced three-variable Lorenz model) that is of course not realistic to represent the events considered. As a continuation of this stream of work, we therefore propose an implementation of the DADA approach in a realistic intermediate complexity atmospheric model (ICTP AGCM, nicknamed SPEEDY). The SPEEDY model is based on a spectral dynamical core developed at the Geophysical Fluid Dynamics Laboratory (see Held and Suarez 1994). It is a hydrostatic, r-coordinate, spectral-transform model in the vorticity-divergence form described by Bourke (1974). A synthetic dataset of observations of an extreme precipitation event over Southeastern South America is extracted from a long SPEEDY simulation under present climatic conditions (i.e. factual conditions). Then, following the DADA approach, observations of this event are assimilated twice in the SPEEDY model: first in the factual configuration of the model and second under its counterfactual, pre-industrial configuration. We show that attribution can be performed based on the likelihood ratio as in Hannart et al. 2015, but we further extend this result by showing that the likelihood can be split in space, time and variables in order to help identify the specific physical features of the event that bear the causal signature. References: Hannart A., A. Carrassi, M. Bocquet, M. Ghil, P. Naveau, M. Pulido, J. Ruiz, P. Tandeo (2015) DADA: Data assimilation for the detection and

  10. Infrared Imaging of Transient Luminous Events (1 - 1.5 micron) Over the Mid-Western US and Comparison With Their Visible Wavelength Signatures

    NASA Astrophysics Data System (ADS)

    Taylor, M. J.; Pautet, D.; Bailey, M.; Lyons, W. A.; Nelson, T. E.; Cummer, S.; Jaugey, N.; Gerken, E.

    2005-12-01

    As part of a coordinated campaign conducted from Yucca Ridge, Colorado, during summer, 2005, four sensitive imaging systems were fielded by Utah State University to investigate the signatures of transient luminous events (TLEs) over a broad spectral range, extending from the near ultra violet (0.35 microns) to infrared wavelengths (1.5 microns). These measurements were made in conjunction with high speed video and electromagnetic observations providing detailed information of the TLE dynamics and their structures. The USU instruments consisted of two Gen 3 Xybion cameras, one filtered to observe N2 first positive emissions (665 nm) while the second observed white light emissions. A third intensified camera with an extended blue response was fitted with a broad band filter to observe the N2+ first negative and N2 second positive emissions (band width, 350-475 nm). Novel infrared measurements were made using an InGaAs imaging array operating at video rates. All four cameras had similar field of view (25°) and were co-aligned on a single mount with the high speed imager. We discovered that sprites were easily imaged in the infrared spectral range, and over 30 events were captured with the InGaAs camera arising from thunderstorms over the mid-western United States during early July and mid August. This talk will focus on new measurements of the optical characteristics of TLEs imaged in the infrared spectral range (1-1.5 microns) and an initial comparison with their visible and near UV signatures.

  11. Lightning-driven electric fields measured in the upper mesosphere and lower ionosphere during the Thunderstorm-III rocket campaign: Implications for transient luminous events

    NASA Astrophysics Data System (ADS)

    Thomas, J. N.; Barnum, B. H.; Holzworth, R. H.; Lay, E. H.; Cho, M.

    2006-12-01

    On September 1, 1995, the Thunderstorm-III sounding rocket was launched from Wallops Island, VA, USA to measure the effects of lightning on the ionosphere. Thunderstorm-III measured hundreds of electric and magnetic field changes from an active storm near Wallops Island and a few other more distant storms. Although the majority of these measurements occurred at altitudes above 130 km, there were 60 lightning- driven electric field changes measured at 75-130 km altitude during the rocket descent. Most of these lightning occurred at horizontal distances of 250-300 km from the rocket as located by the National Lightning Detection Network. At these distances, weak quasi-static electric field components and strong electromagnetic components were measured. These are some of the only lightning-driven electric fields measured in the upper mesosphere / lower ionosphere ever to be reported, since this region is typically too low in altitude for rockets and satellites and too high for balloons. In this presentation, these electric field changes are summarized and a few detailed case studies are presented. Moreover, these measurements are compared directly to a 2-D numerical model of lightning-driven electromagnetic fields in the middle and upper atmosphere. Finally, the implications of these results for transient luminous events, such as sprites, elves, and halos that have been observed at these altitudes are discussed.

  12. Design and performances of microcameras and photometers instruments on TARANIS satellite for an advanced characterization of Transient Luminous Event in the upper atmosphere

    NASA Astrophysics Data System (ADS)

    Le Mer-Dachard, Fanny; Cansot, Elodie; Hébert, Philippe; Farges, Thomas; Ravel, Karen; Gaillac, Stéphanie

    2015-10-01

    The TARANIS mission aims at studying upper atmosphere coupling with a scientific nadir-pointing microsatellite - CNES Myriade family - at a low-altitude orbit (700 km). The main objectives are to measure the occurrence of Transient Luminous Event (TLE), impulsive energetic optical phenomena generated by storms according to recently discovered process, and Terrestrial Gamma-ray Flash (TGF), their emissions and trigger factors. TARANIS instruments are currently in manufacturing, assembly, integration and testing phase. The MicroCameras and Photometers instruments (MCP) are in charge of the remote sensing of the sprites and the lightning in optical wavelengths. MicroCameras instrument [MCP-MC] is an imager in the visible and Photometers instrument [MCP-PH] is a radiometer with four bands from UV to NIR, able to detect TLEs on-board and to trigger the whole payload. The satellite will provide a complete survey of the atmosphere in low resolution together with a high resolution data of sites of interest automatically detected on board. For MC and PH instruments, CEA defined scientific needs and is in charge of processing data and providing scientific results. CNES described the technical requirements of these two instruments and will run in-flight commissioning. Design, manufacturing and testing is under responsibility of Sodern for MicroCameras and Bertin Technologies for Photometers. This article shortly describes physical characteristics of TLEs and presents the final design of these instruments and first measured performances.

  13. Effect of supply voltage and body-biasing on single-event transient pulse quenching in bulk fin field-effect-transistor process

    NASA Astrophysics Data System (ADS)

    Jun-Ting, Yu; Shu-Ming, Chen; Jian-Jun, Chen; Peng-Cheng, Huang; Rui-Qiang, Song

    2016-04-01

    Charge sharing is becoming an important topic as the feature size scales down in fin field-effect-transistor (FinFET) technology. However, the studies of charge sharing induced single-event transient (SET) pulse quenching with bulk FinFET are reported seldomly. Using three-dimensional technology computer aided design (3DTCAD) mixed-mode simulations, the effects of supply voltage and body-biasing on SET pulse quenching are investigated for the first time in bulk FinFET process. Research results indicate that due to an enhanced charge sharing effect, the propagating SET pulse width decreases with reducing supply voltage. Moreover, compared with reverse body-biasing (RBB), the circuit with forward body-biasing (FBB) is vulnerable to charge sharing and can effectively mitigate the propagating SET pulse width up to 53% at least. This can provide guidance for radiation-hardened bulk FinFET technology especially in low power and high performance applications. Project supported by the National Natural Science Foundation of China (Grant Nos. 61376109, 61434007, and 61176030).

  14. Downscaling 20th century flooding events in complex terrain (Switzerland) using the WRF regional climate model

    NASA Astrophysics Data System (ADS)

    Heikkilä, Ulla; Gómez Navarro, Juan Jose; Franke, Jörg; Brönnimann, Stefan; Cattin, Réne

    2016-04-01

    Switzerland has experienced a number of severe precipitation events during the last few decades, such as during the 14-16 November of 2002 or during the 21-22 August of 2005. Both events, and subsequent extreme floods, caused fatalities and severe financial losses, and have been well studied both in terms of atmospheric conditions leading to extreme precipitation, and their consequences [e.g. Hohenegger et al., 2008, Stucki et al., 2012]. These examples highlight the need to better characterise the frequency and severity of flooding in the Alpine area. In a larger framework we will ultimately produce a high-resolution data set covering the entire 20th century to be used for detailed hydrological studies including all atmospheric parameters relevant for flooding events. In a first step, we downscale the aforementioned two events of 2002 and 2005 to assess the model performance regarding precipitation extremes. The complexity of the topography in the Alpine area demands high resolution datasets. To achieve a sufficient detail in resolution we employ the Weather Research and Forecasting regional climate model (WRF). A set of 4 nested domains is used with a 2-km resolution horizontal resolution over Switzerland. The NCAR 20th century reanalysis (20CR) with a horizontal resolution of 2.5° serves as boundary condition [Compo et al., 2011]. First results of the downscaling the 2002 and 2005 extreme precipitation events show that, compared to station observations provided by the Swiss Meteorological Office MeteoSwiss, the model strongly underestimates the strength of these events. This is mainly due to the coarse resolution of the 20CR data, which underestimates the moisture fluxes during these events. We tested driving WRF with the higher-resolved NCEP reanalysis and found a significant improvement in the amount of precipitation of the 2005 event. In a next step we will downscale the precipitation and wind fields during a 6-year period 2002-2007 to investigate and

  15. Ultrafast transient absorption spectroscopy: principles and application to photosynthetic systems.

    PubMed

    Berera, Rudi; van Grondelle, Rienk; Kennis, John T M

    2009-01-01

    The photophysical and photochemical reactions, after light absorption by a photosynthetic pigment-protein complex, are among the fastest events in biology, taking place on timescales ranging from tens of femtoseconds to a few nanoseconds. The advent of ultrafast laser systems that produce pulses with femtosecond duration opened up a new area of research and enabled investigation of these photophysical and photochemical reactions in real time. Here, we provide a basic description of the ultrafast transient absorption technique, the laser and wavelength-conversion equipment, the transient absorption setup, and the collection of transient absorption data. Recent applications of ultrafast transient absorption spectroscopy on systems with increasing degree of complexity, from biomimetic light-harvesting systems to natural light-harvesting antennas, are presented. In particular, we will discuss, in this educational review, how a molecular understanding of the light-harvesting and photoprotective functions of carotenoids in photosynthesis is accomplished through the application of ultrafast transient absorption spectroscopy.

  16. Heart Rate Deceleration as a Function of Viewing Complex Visual Events in Eighteen-Month-Old Infants.

    ERIC Educational Resources Information Center

    Gilmore, Lowry M.; And Others

    This research project assessed: (1) the practicality of recording heart rate in 18-month-old infants as they watched events filmed on color, silent motion picture films; and (2) the validity and sensitivity of heart rate change as an index of differential attention arousal elicited by changes within and between complex visual events. The research…

  17. Light Curves and Radio Structure of the 1999 September Transient Event in V4641 Sagittarii (=XTE J1819-254=SAX J1819.3-2525)

    NASA Astrophysics Data System (ADS)

    Hjellming, R. M.; Rupen, M. P.; Hunstead, R. W.; Campbell-Wilson, D.; Mioduszewski, A. J.; Gaensler, B. M.; Smith, D. A.; Sault, R. J.; Fender, R. P.; Spencer, R. E.; de la Force, C. J.; Richards, A. M. S.; Garrington, S. T.; Trushkin, S. A.; Ghigo, F. D.; Waltman, E. B.; McCollough, M.

    2000-12-01

    We report on radio observations of the 1999 September event of the X-ray transient V4641 Sgr (=XTE J1819-254=SAX J1819.3-2525). This event was extremely rapid in its rise and decay across radio, optical, and X-ray wavelengths; the X-rays rose to 12 crab within 8 hr and faded to below 0.1 crab in less than 2 hr. Radio observations were made with seven telescopes during the first day following the onset of the strong X-ray event, revealing a strong radio source that was detected for 3 further weeks by the more sensitive telescopes. The radio source was resolved even in the first Very Large Array (VLA) images (September 16.027 UT), being ~0.25" long with an axis ratio of at least 10:1. The total flux density decayed by a factor of ~4 over the first day, and by September 17.94 UT the radio emission was confined to a slowly decaying, marginally resolved remnant located at one side of the early elongated emission. The H I absorption spectrum gives a minimum kinematic distance of about 400 pc; various other arguments suggest that the true distance is not much greater than this. The inferred proper motions for the early extended emission (0.4"-1.1" day-1) correspond to v/c~1.0-3.2 (d/0.5 kpc), and this together with the radio morphology argues that this is a relativistic jet source like GRS 1915+105 and GRO J1655-40. The proper motion of the late-time remnant is at least 100 times smaller. One simple interpretation posits the ejection of a single short-lived jet segment, followed by a more slowly decaying, optically thin jet segment ejection. These two components can explain both the multifrequency radio light curves and the radio images. The most likely parameters for the fast-jet system with net-averaged proper motion of ~0.4" day-1, assuming d=0.5 kpc, are v~0.85c and i~63deg, where i is the inclination to the line of sight. The corresponding apparent velocities are 1.4c and 0.6c for the approaching and receding jets, making V4641 Sgr the closest superluminal jet source

  18. Multisensory temporal function and EEG complexity in patients with epilepsy and psychogenic nonepileptic events.

    PubMed

    Noel, Jean-Paul; Kurela, LeAnne; Baum, Sarah H; Yu, Hong; Neimat, Joseph S; Gallagher, Martin J; Wallace, Mark

    2017-05-01

    Cognitive and perceptual comorbidities frequently accompany epilepsy and psychogenic nonepileptic events (PNEE). However, and despite the fact that perceptual function is built upon a multisensory foundation, little knowledge exists concerning multisensory function in these populations. Here, we characterized facets of multisensory processing abilities in patients with epilepsy and PNEE, and probed the relationship between individual resting-state EEG complexity and these psychophysical measures in each patient. We prospectively studied a cohort of patients with epilepsy (N=18) and PNEE (N=20) patients who were admitted to Vanderbilt's Epilepsy Monitoring Unit (EMU) and weaned off of anticonvulsant drugs. Unaffected age-matched persons staying with the patients in the EMU (N=15) were also recruited as controls. All participants performed two tests of multisensory function: an audio-visual simultaneity judgment and an audio-visual redundant target task. Further, in the cohort of patients with epilepsy and PNEE we quantified resting state EEG gamma power and complexity. Compared with both patients with epilepsy and control subjects, patients with PNEE exhibited significantly poorer acuity in audiovisual temporal function as evidenced in significantly larger temporal binding windows (i.e., they perceived larger stimulus asynchronies as being presented simultaneously). These differences appeared to be specific for temporal function, as there was no difference among the three groups in a non-temporally based measure of multisensory function - the redundant target task. Further, patients with PNEE exhibited more complex resting state EEG patterns as compared to their patients with epilepsy, and EEG complexity correlated with multisensory temporal performance on a subject-by-subject manner. Taken together, findings seem to indicate that patients with PNEE bind information from audition and vision over larger temporal intervals when compared with control subjects as well

  19. A prediction technique for single-event effects on complex integrated circuits

    NASA Astrophysics Data System (ADS)

    Yuanfu, Zhao; Chunqing, Yu; Long, Fan; Suge, Yue; Maoxin, Chen; Shougang, Du; Hongchao, Zheng

    2015-11-01

    The sensitivity of complex integrated circuits to single-event effects is investigated. Sensitivity depends not only on the cross section of physical modules but also on the behavior of data patterns running on the system. A method dividing the main functional modules is proposed. The intrinsic cross section and the duty cycles of different sensitive modules are obtained during the execution of data patterns. A method for extracting the duty cycle is presented and a set of test patterns with different duty cycles are implemented experimentally. By combining the intrinsic cross section and the duty cycle of different sensitive modules, a universal method to predict SEE sensitivities of different test patterns is proposed, which is verified by experiments based on the target circuit of a microprocessor. Experimental results show that the deviation between prediction and experiment is less than 20%.

  20. Effects of target routing model on the occurrence of extreme events in complex networks

    NASA Astrophysics Data System (ADS)

    Ling, Xiang; Hu, Mao-Bin; Ding, Jian-Xun; Shi, Qing; Jiang, Rui

    2013-04-01

    This paper investigates the effect of routing protocol on the occurrence of extreme events (EE) in complex networks, as an extension of [V. Kishore, M.S. Santhanam, R.E. Amritkar, Phys. Rev. Lett. 106, 188701 (2011)]. The target routing model [W.X. Wang, B.H. Wang, C.Y. Yin, Y.B. Xie, T. Zhou, Phys. Rev. E 73, 026111 (2006)] is considered. In the model, a tunable power parameter α controls the packets' preference of forwarding direction. We derive exact expressions for the stationary distribution probability of packets and estimate the occurrence probability of EE on the nodes. The occurrence of EE strongly depends on the routing parameter. For Barabási-Albert scale-free network, Erdös-Rényi random network and Newman-Watts small-world network, it is shown that the minimal occurrence of EE is achieved at α = -1.

  1. SR proteins control a complex network of RNA-processing events.

    PubMed

    Bradley, Todd; Cook, Malcolm E; Blanchette, Marco

    2015-01-01

    SR proteins are a well-conserved class of RNA-binding proteins that are essential for regulation of splice-site selection, and have also been implicated as key regulators during other stages of RNA metabolism. For many SR proteins, the complexity of the RNA targets and specificity of RNA-binding location are poorly understood. It is also unclear if general rules governing SR protein alternative pre-mRNA splicing (AS) regulation uncovered for individual SR proteins on few model genes, apply to the activity of all SR proteins on endogenous targets. Using RNA-seq, we characterize the global AS regulation of the eight Drosophila SR protein family members. We find that a majority of AS events are regulated by multiple SR proteins, and that all SR proteins can promote exon inclusion, but also exon skipping. Most coregulated targets exhibit cooperative regulation, but some AS events are antagonistically regulated. Additionally, we found that SR protein levels can affect alternative promoter choices and polyadenylation site selection, as well as overall transcript levels. Cross-linking and immunoprecipitation coupled with high-throughput sequencing (iCLIP-seq), reveals that SR proteins bind a distinct and functionally diverse class of RNAs, which includes several classes of noncoding RNAs, uncovering possible novel functions of the SR protein family. Finally, we find that SR proteins exhibit positional RNA binding around regulated AS events. Therefore, regulation of AS by the SR proteins is the result of combinatorial regulation by multiple SR protein family members on most endogenous targets, and SR proteins have a broader role in integrating multiple layers of gene expression regulation. © 2014 Bradley et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  2. SR proteins control a complex network of RNA-processing events

    PubMed Central

    Bradley, Todd; Cook, Malcolm E.

    2015-01-01

    SR proteins are a well-conserved class of RNA-binding proteins that are essential for regulation of splice-site selection, and have also been implicated as key regulators during other stages of RNA metabolism. For many SR proteins, the complexity of the RNA targets and specificity of RNA-binding location are poorly understood. It is also unclear if general rules governing SR protein alternative pre-mRNA splicing (AS) regulation uncovered for individual SR proteins on few model genes, apply to the activity of all SR proteins on endogenous targets. Using RNA-seq, we characterize the global AS regulation of the eight Drosophila SR protein family members. We find that a majority of AS events are regulated by multiple SR proteins, and that all SR proteins can promote exon inclusion, but also exon skipping. Most coregulated targets exhibit cooperative regulation, but some AS events are antagonistically regulated. Additionally, we found that SR protein levels can affect alternative promoter choices and polyadenylation site selection, as well as overall transcript levels. Cross-linking and immunoprecipitation coupled with high-throughput sequencing (iCLIP-seq), reveals that SR proteins bind a distinct and functionally diverse class of RNAs, which includes several classes of noncoding RNAs, uncovering possible novel functions of the SR protein family. Finally, we find that SR proteins exhibit positional RNA binding around regulated AS events. Therefore, regulation of AS by the SR proteins is the result of combinatorial regulation by multiple SR protein family members on most endogenous targets, and SR proteins have a broader role in integrating multiple layers of gene expression regulation. PMID:25414008

  3. Words Analysis of Online Chinese News Headlines about Trending Events: A Complex Network Perspective

    PubMed Central

    Li, Huajiao; Fang, Wei; An, Haizhong; Huang, Xuan

    2015-01-01

    Because the volume of information available online is growing at breakneck speed, keeping up with meaning and information communicated by the media and netizens is a new challenge both for scholars and for companies who must address public relations crises. Most current theories and tools are directed at identifying one website or one piece of online news and do not attempt to develop a rapid understanding of all websites and all news covering one topic. This paper represents an effort to integrate statistics, word segmentation, complex networks and visualization to analyze headlines’ keywords and words relationships in online Chinese news using two samples: the 2011 Bohai Bay oil spill and the 2010 Gulf of Mexico oil spill. We gathered all the news headlines concerning the two trending events in the search results from Baidu, the most popular Chinese search engine. We used Simple Chinese Word Segmentation to segment all the headlines into words and then took words as nodes and considered adjacent relations as edges to construct word networks both using the whole sample and at the monthly level. Finally, we develop an integrated mechanism to analyze the features of words’ networks based on news headlines that can account for all the keywords in the news about a particular event and therefore track the evolution of news deeply and rapidly. PMID:25807376

  4. Words analysis of online Chinese news headlines about trending events: a complex network perspective.

    PubMed

    Li, Huajiao; Fang, Wei; An, Haizhong; Huang, Xuan

    2015-01-01

    Because the volume of information available online is growing at breakneck speed, keeping up with meaning and information communicated by the media and netizens is a new challenge both for scholars and for companies who must address public relations crises. Most current theories and tools are directed at identifying one website or one piece of online news and do not attempt to develop a rapid understanding of all websites and all news covering one topic. This paper represents an effort to integrate statistics, word segmentation, complex networks and visualization to analyze headlines' keywords and words relationships in online Chinese news using two samples: the 2011 Bohai Bay oil spill and the 2010 Gulf of Mexico oil spill. We gathered all the news headlines concerning the two trending events in the search results from Baidu, the most popular Chinese search engine. We used Simple Chinese Word Segmentation to segment all the headlines into words and then took words as nodes and considered adjacent relations as edges to construct word networks both using the whole sample and at the monthly level. Finally, we develop an integrated mechanism to analyze the features of words' networks based on news headlines that can account for all the keywords in the news about a particular event and therefore track the evolution of news deeply and rapidly.

  5. Sentiment Diffusion of Public Opinions about Hot Events: Based on Complex Network

    PubMed Central

    Hao, Xiaoqing; An, Haizhong; Zhang, Lijia; Li, Huajiao; Wei, Guannan

    2015-01-01

    To study the sentiment diffusion of online public opinions about hot events, we collected people’s posts through web data mining techniques. We calculated the sentiment value of each post based on a sentiment dictionary. Next, we divided those posts into five different orientations of sentiments: strongly positive (P), weakly positive (p), neutral (o), weakly negative (n), and strongly negative (N). These sentiments are combined into modes through coarse graining. We constructed sentiment mode complex network of online public opinions (SMCOP) with modes as nodes and the conversion relation in chronological order between different types of modes as edges. We calculated the strength, k-plex clique, clustering coefficient and betweenness centrality of the SMCOP. The results show that the strength distribution obeys power law. Most posts’ sentiments are weakly positive and neutral, whereas few are strongly negative. There are weakly positive subgroups and neutral subgroups with ppppp and ooooo as the core mode, respectively. Few modes have larger betweenness centrality values and most modes convert to each other with these higher betweenness centrality modes as mediums. Therefore, the relevant person or institutes can take measures to lead people’s sentiments regarding online hot events according to the sentiment diffusion mechanism. PMID:26462230

  6. Sentiment Diffusion of Public Opinions about Hot Events: Based on Complex Network.

    PubMed

    Hao, Xiaoqing; An, Haizhong; Zhang, Lijia; Li, Huajiao; Wei, Guannan

    2015-01-01

    To study the sentiment diffusion of online public opinions about hot events, we collected people's posts through web data mining techniques. We calculated the sentiment value of each post based on a sentiment dictionary. Next, we divided those posts into five different orientations of sentiments: strongly positive (P), weakly positive (p), neutral (o), weakly negative (n), and strongly negative (N). These sentiments are combined into modes through coarse graining. We constructed sentiment mode complex network of online public opinions (SMCOP) with modes as nodes and the conversion relation in chronological order between different types of modes as edges. We calculated the strength, k-plex clique, clustering coefficient and betweenness centrality of the SMCOP. The results show that the strength distribution obeys power law. Most posts' sentiments are weakly positive and neutral, whereas few are strongly negative. There are weakly positive subgroups and neutral subgroups with ppppp and ooooo as the core mode, respectively. Few modes have larger betweenness centrality values and most modes convert to each other with these higher betweenness centrality modes as mediums. Therefore, the relevant person or institutes can take measures to lead people's sentiments regarding online hot events according to the sentiment diffusion mechanism.

  7. A Validation System for the Complex Event Processing Directives of the ATLAS Shifter Assistant Tool

    NASA Astrophysics Data System (ADS)

    Santos, A.; Anders, G.; Avolio, G.; Kazarov, A.; Lehmann Miotto, G.; Soloviev, I.

    2015-12-01

    Complex Event Processing (CEP) is a methodology that combines data from many sources in order to identify events or patterns that need particular attention. It has gained a lot of momentum in the computing world in the past few years and is used in ATLAS to continuously monitor the behaviour of the data acquisition system, to trigger corrective actions and to guide the experiment's operators. This technology is very powerful, if experts regularly insert and update their knowledge about the system's behaviour into the CEP engine. Nevertheless, writing or modifying CEP rules is not trivial since the used programming paradigm is quite different with respect to what developers are normally familiar with. In order to help experts verify that the rules work as expected, we have thus developed a complete testing and validation environment. This system consists of three main parts: the first is the data reader from existing storage of all relevant data streams that are produced during data taking, the second is a playback tool that allows to re-inject data of specific data taking sessions from the past into the CEP engine, and the third is a reporting tool that shows the output that the rules loaded into the engine would have produced in the live system. In this paper we describe the design and implementation of this validation system, highlight its strengths and shortcomings and indicate how such a system could be reused in similar projects.

  8. Neurovascular and Neurometabolic Couplings in Dynamic Calibrated fMRI: Transient Oxidative Neuroenergetics for Block-Design and Event-Related Paradigms

    PubMed Central

    Hyder, Fahmeed; Sanganahalli, Basavaraju G.; Herman, Peter; Coman, Daniel; Maandag, Natasja J. G.; Behar, Kevin L.; Blumenfeld, Hal; Rothman, Douglas L.

    2010-01-01

    Functional magnetic resonance imaging (fMRI) with blood-oxygenation level dependent (BOLD) contrast is an important tool for mapping brain activity. Interest in quantitative fMRI has renewed awareness in importance of oxidative neuroenergetics, as reflected by cerebral metabolic rate of oxygen consumption(CMRO2), for supporting brain function. Relationships between BOLD signal and the underlying neurophysiological parameters have been elucidated to allow determination of dynamic changes inCMRO2 by “calibrated fMRI,” which require multi-modal measurements of BOLD signal along with cerebral blood flow (CBF) and volume (CBV). But how doCMRO2 changes, steady-state or transient, derived from calibrated fMRI compare with neural activity recordings of local field potential (LFP) and/or multi-unit activity (MUA)? Here we discuss recent findings primarily from animal studies which allow high magnetic fields studies for superior BOLD sensitivity as well as multi-modal CBV and CBF measurements in conjunction with LFP and MUA recordings from activated sites. A key observation is that while relationships between neural activity and sensory stimulus features range from linear to non-linear, associations between hyperemic components (BOLD, CBF, CBV) and neural activity (LFP, MUA) are almost always linear. More importantly, the results demonstrate good agreement between the changes inCMRO2 and independent measures of LFP or MUA. The tight neurovascular and neurometabolic couplings, observed from steady-state conditions to events separated by <200 ms, suggest rapid oxygen equilibration between blood and tissue pools and thus calibrated fMRI at high magnetic fields can provide high spatiotemporal mapping ofCMRO2 changes. PMID:20838476

  9. Radiochemical data collected on events from which radioactivity escaped beyond the borders of the Nevada test range complex. [NONE

    SciTech Connect

    Hicks, H.G.

    1981-02-12

    This report identifies all nuclear events in Nevada that are known to have sent radioactivity beyond the borders of the test range complex. There have been 177 such tests, representing seven different types: nuclear detonations in the atmosphere, nuclear excavation events, nuclear safety events, underground nuclear events that inadvertently seeped or vented to the atmosphere, dispersion of plutonium and/or uranium by chemical high explosives, nuclear rocket engine tests, and nuclear ramjet engine tests. The source term for each of these events is given, together with the data base from which it was derived (except where the data are classified). The computer programs used for organizing and processing the data base and calculating radionuclide production are described and included, together with the input and output data and details of the calculations. This is the basic formation needed to make computer modeling studies of the fallout from any of these 177 events.

  10. Complex Negative Regulation of TLR9 by Multiple Proteolytic Cleavage Events.

    PubMed

    Sinha, Siddhartha S; Cameron, Jody; Brooks, James C; Leifer, Cynthia A

    2016-08-15

    TLR9 is an innate immune receptor important for recognizing DNA of host and foreign origin. A mechanism proposed to prevent excessive response to host DNA is the requirement for proteolytic cleavage of TLR9 in endosomes to generate a mature form of the receptor (TLR9(471-1032)). We previously described another cleavage event in the juxtamembrane region of the ectodomain that generated a dominant-negative form of TLR9. Thus, there are at least two independent cleavage events that regulate TLR9. In this study, we investigated whether an N-terminal fragment of TLR9 could be responsible for regulation of the mature or negative-regulatory form. We show that TLR9(471-1032), corresponding to the proteolytically cleaved form, does not function on its own. Furthermore, activity is not rescued by coexpression of the N-terminal fragment (TLR9(1-440)), inclusion of the hinge region (TLR9(441-1032)), or overexpression of UNC93B1, the last of which is critical for trafficking and cleavage of TLR9. TLR9(1-440) coimmunoprecipitates with full-length TLR9 and TLR9(471-1032) but does not rescue the native glycosylation pattern; thus, inappropriate trafficking likely explains why TLR9(471-1032) is nonfunctional. Lastly, we show that TLR9(471-1032) is also a dominant-negative regulator of TLR9 signaling. Together, these data provide a new perspective on the complexity of TLR9 regulation by proteolytic cleavage and offer potential ways to inhibit activity through this receptor, which may dampen autoimmune inflammation.

  11. Transient cell–cell interactions in neural circuit formation

    PubMed Central

    Chao, Daniel L.; Ma, Le; Shen, Kang

    2011-01-01

    The wiring of the nervous system requires a complex orchestration of developmental events. Emerging evidence suggests that transient cell–cell interactions often serve as positional cues for axon guidance and synaptogenesis during the assembly of neural circuits. In contrast to the relatively stable cellular interactions between synaptic partners in mature circuits, these transient interactions involve cells that are not destined to be pre- or postsynaptic cells. Here we review the roles of these transient cell–cell interactions in a variety of developmental contexts and describe the mechanisms through which they organize neural connections. PMID:19300445

  12. Strategy for introduction of rainwater management facility considering rainfall event applied on new apartment complex

    NASA Astrophysics Data System (ADS)

    KIM, H.; Lee, D. K.; Yoo, S.

    2014-12-01

    As regional torrential rains become frequent due to climate change, urban flooding happens very often. That is why it is necessary to prepare for integrated measures against a wide range of rainfall. This study proposes introduction of effective rainwater management facilities to maximize the rainwater runoff reductions and recover natural water circulation for unpredictable extreme rainfall in apartment complex scale. The study site is new apartment complex in Hanam located in east of Seoul, Korea. It has an area of 7.28ha and is analysed using the EPA-SWMM and STORM model. First, it is analyzed that green infrastructure(GI) had efficiency of flood reduction at the various rainfall events and soil characteristics, and then the most effective value of variables are derived. In case of rainfall event, Last 10 years data of 15 minutes were used for analysis. A comparison between A(686mm rainfall during 22days) and B(661mm/4days) knew that soil infiltration of A is 17.08% and B is 5.48% of the rainfall. Reduction of runoff after introduction of the GI of A is 24.76% and B is 6.56%. These results mean that GI is effective to small rainfall intensity, and artificial rainwater retarding reservoir is needed at extreme rainfall. Second, set of target year is conducted for the recovery of hydrological cycle at the predevelopment. And an amount of infiltration, evaporation, surface runoff of the target year and now is analysed on the basis of land coverage, and an arrangement of LID facilities. Third, rainwater management scenarios are established and simulated by the SWMM-LID. Rainwater management facilities include GI(green roof, porous pavement, vegetative swale, ecological pond, and raingarden), and artificial rainwater. Design scenarios are categorized five type: 1)no GI, 2)conventional GI design(current design), 3)intensive GI design, 4)GI design+rainwater retarding reservoir 5)maximized rainwater retarding reservoir. Intensive GI design is to have attribute value to

  13. Comparing rainfall variability, model complexity and hydrological response at the intra-event scale

    NASA Astrophysics Data System (ADS)

    Cristiano, Elena; ten Veldhuis, Marie-claire; Ochoa-Rodriguez, Susana; van de Giesen, Nick

    2017-04-01

    The high variability in space and time of rainfall is one of the main aspects that influence hydrological response and generation of pluvial flooding. This phenomenon has a bigger impact in urban areas, where response is usually faster and flow peaks are typically higher, due to the high degree of imperviousness. Previous researchers have investigated sensitivity of urban hydrodynamic models to rainfall space-time resolution as well as interactions with model structure and resolution. They showed that finding a proper match between rainfall resolution and model complexity is important and that sensitivity increases for smaller urban catchment scales. Results also showed high variability in hydrological response sensitivity, the origins of which remain poorly understood. In this work, we investigate the interaction between rainfall input variability and model structure and scale at high resolution, i.e. 1-15 minutes in time and 100m to 3 km in space. Apart from studying summary statistics such as relative peak flow errors and coefficient of determination, we look into characteristics of response hydrographs to find explanations for response variability in relation to catchment properties as well storm event characteristics (e.g. storm scale and movement, single-peak versus multi-peak events). The aim is to identify general relations between storm temporal and spatial scale and catchment scale in explaining variability of hydrological response. Analyses are conducted for the Cranbrook catchment (London, UK), using 3 hydrodynamic models set up in InfoWorks ICM: a low resolution semi-distributed (SD1) model, a high resolution semi-distributed (SD2) model and a fully distributed (FD) model. These models represent the spatial variability of the land in different ways: semi-distributed models divide the surface in subcatchments, each of them modelled in a lumped way (51 subcatchment for the S model and 4409 subcatchments for the SD model), while the fully distributed

  14. Error Analysis of Satellite Precipitation-Driven Modeling of Complex Terrain Flood Events

    NASA Astrophysics Data System (ADS)

    Mei, Y.; Nikolopoulos, E. I.; Anagnostou, E. N.; Zoccatelli, D.; Borga, M., Sr.

    2015-12-01

    The error characteristics of satellite precipitation driven flood event simulations over mountainous basins are evaluated in this study for eight different global satellite products. A methodology is devised to match the observed records of the flood events with the corresponding satellite and reference rainfall and runoff simulations. The flood events are sorted according to flood type (i.e. rain flood and flash flood) and basin's antecedent conditions represented by the event's runoff-to-precipitation ratio. The satellite precipitation products and runoff simulations are evaluated based on systematic and random error metrics applied on the matched event pairs and basin scale event properties (i.e. cumulative volume, timing and shape). Overall satellite-driven event runoff exhibits better error metrics than the satellite precipitation. Better error metrics are also shown for the rain flood events relative to the flash flood events. The event timing and shape from satellite-derived precipitation agreed well with the reference; the cumulative volume is mostly underestimated. In terms of error propagation, the study shows dampening effect in both systematic and random error components of the satellite-driven runoff time series relative to the satellite-retrieved event precipitation. This error dampening effect is less pronounced for the flash flood events and the rain flood events with high runoff coefficients. This study provides for a first time flood event characteristics of the satellite precipitation error propagation in flood modeling, which has implications on the Global Precipitation Measurement application in mountain flood hydrology.

  15. Effects of musical training and event probabilities on encoding of complex tone patterns.

    PubMed

    Kuchenbuch, Anja; Paraskevopoulos, Evangelos; Herholz, Sibylle C; Pantev, Christo

    2013-04-24

    The human auditory cortex automatically encodes acoustic input from the environment and differentiates regular sound patterns from deviant ones in order to identify important, irregular events. The Mismatch Negativity (MMN) response is a neuronal marker for the detection of sounds that are unexpected, based on the encoded regularities. It is also elicited by violations of more complex regularities and musical expertise has been shown to have an effect on the processing of complex regularities. Using magnetoencephalography (MEG), we investigated the MMN response to salient or less salient deviants by varying the standard probability (70%, 50% and 35%) of a pattern oddball paradigm. To study the effects of musical expertise in the encoding of the patterns, we compared the responses of a group of non-musicians to those of musicians. We observed significant MMN in all conditions, including the least salient condition (35% standards), in response to violations of the predominant tone pattern for both groups. The amplitude of MMN from the right hemisphere was influenced by the standard probability. This effect was modulated by long-term musical training: standard probability changes influenced MMN amplitude in the group of non-musicians only. This study indicates that pattern violations are detected automatically, even if they are of very low salience, both in non-musicians and musicians, with salience having a stronger impact on processing in the right hemisphere of non-musicians. Long-term musical training influences this encoding, in that non-musicians benefit to a greater extent from a good signal-to-noise ratio (i.e. high probability of the standard pattern), while musicians are less dependent on the salience of an acoustic environment.

  16. Observations of prolific transient luminous event production above a mesoscale convective system in Argentina during the Sprite2006 Campaign in Brazil

    NASA Astrophysics Data System (ADS)

    SãO Sabbas, F. T.; Taylor, M. J.; Pautet, P.-D.; Bailey, M.; Cummer, S.; Azambuja, R. R.; Santiago, J. P. C.; Thomas, J. N.; Pinto, O.; Solorzano, N. N.; Schuch, N. J.; Freitas, S. R.; Ferreira, N. J.; Conforte, J. C.

    2010-11-01

    On the night of 22-23 February 2006, 444 transient luminous events (TLEs), 86% sprites, were observed above a prolific mesoscale convective system (MCS) over Argentina, as part of the third sprite campaign in Brazil. GOES infrared (IR) cloud top temperatures (Tc) and Tropical Rainfall Measuring Mission (TRMM) radar (PR) and microwave (TMI) data were used to investigate the MCS convective characteristics and their relationship with World Wide Location Network (WWLLN) detected cloud-to-ground (CG) lightning and TLE activity. The MCS had a minimum lifetime of 20 hours, 8.5 as a MCS, a maximum extent of ˜430,000 km2, and gusty winds of ˜39-50 km/h. It had several distinctive characteristics: exceptionally high TLE rate, multicellular structure with 19 distinguishable convective regions, and cloud tops temperatures (Tc) ˜10-20 °C higher than regular TLE-producing MCSs over the central USA and South America. Most TLEs occurred above "individual stratiform regions", where Tc varied from -45 °C to -53 °C from the beginning to the end of the night, surrounding the areas of strong convections, with convective cores at Tc -59 °C to -74 °C, which did not extend up to or overshoot the tropopause, estimated at -75 °C (˜17.1 km) as normally observed for TLE-producing MCS in these regions. The moderated convection is contrary to the expectation that large charge production is accompanied by vigorous updrafts within deep convection that give rise to cold cloud overshooting tops, thus prompting a detailed study of this prolific TLE-producing thunderstorm. On the basis of a charge moment change threshold of 350 Ckm and estimated 5 km charge removal altitude, a lower threshold of ˜4,300 C/h was estimated for the hourly charge transfer rate necessary for the observed sprite production (383 events), which is twice the rate for an average TLE-producing MCS (70 events), also estimated. TMI/TRMM data for the storm at early development showed a low brightness temperature of 84 K

  17. Scaling of Dielectric Breakdown Thresholds in Earth's and CO2-rich atmospheres: Impact for Predictions of Extraterrestrial Transient Luminous Events and Lightning Discharges

    NASA Astrophysics Data System (ADS)

    Riousset, J. A.

    2016-12-01

    Earth's atmospheric electricity manifests itself in the form of glow, corona, streamer, and leader discharges observed as Saint Elmo's fire, sprites, lightning and jets discharges, and other Transient Luminous Events (TLEs). All of these are types of dielectric breakdown, but are governed by different physics. In particular, their initiation is associated with the crossing of specific electric field thresholds: relativistic runaway, streamer propagation, conventional breakdown, or thermal runaway thresholds, some better understood than others. For example, the initiation of a lightning discharge is known to occur when the local electric field exceeds a value similar to relativistic runaway field, but the exact threshold, as well as the physical mechanisms at work, remain rather unclear to date. Scaling laws for electric fields (and other quantities) have been established by Pasko et al. [GRL, 25(12), 2123-2126, 1998] and Pasko [NATO Sci. Series, Springer, 253-311, 2006]. In this work, we develop profiles for initiation criteria in air and in other atmospheric environments. We further calculate their associated scaling laws to determine the ability to trigger lightning flashes and TLEs in our solar system. This lets us predict the likelihood of electrical discharges on, e.g., Mars, Venus and Titan, and calculate the expected electric field conditions, under which discharges have been observed on Jupiter, Saturn, Uranus, and Neptune [Leblanc et al., ISSI Spa. Sci. Series, Springer, 2008, Yair, Adv. Space Res., 50(3), 293-310, 2012]. Our results anticipate the arrival of ExoMars 2016's Schiaparelli module, which will provide the first records of electric field at the surface of the planet [Déprez et al., EGU GA, 16, 16613, 2014]. This research is also motived by the increasing probability of manned missions to Mars and the potential electrostatic hazards it may face [Yair, 2012], and by the role of electrical discharges in the creation of active radicals, some of

  18. Luminous Extragalactic Transients

    NASA Astrophysics Data System (ADS)

    O'Brien, Paul; Jonker, Peter; Athena Explosive Transients Working Group

    2015-09-01

    The ESA Athena X-ray observatory mission will combine exceptionally high throughout with high spectral-energy resolution and will revolutionise many aspects of high-energy astrophysics. Many of the most powerful transient sources, including gamma-ray bursts and tidal disruptions events, are bright X-ray sources. Athena will be designed to have a fast-response capability permitting efficient observations of many transients. We will summarise the proposed capability of the mission and illustrate science programs to study transients ranging from the most distant GRBs to nuclear activity in nearby galaxies.

  19. Complex Parts, Complex Data: Why You Need to Understand What Radiation Single Event Testing Data Does and Doesn't Show and the Implications Thereof

    NASA Technical Reports Server (NTRS)

    LaBel, Kenneth A.; Berg, Melanie D.

    2015-01-01

    Electronic parts (integrated circuits) have grown in complexity such that determining all failure modes and risks from single particle event testing is impossible. In this presentation, the authors will present why this is so and provide some realism on what this means. Its all about understanding actual risks and not making assumptions.

  20. Chemotaxis Control of Transient Cell Aggregation.

    PubMed

    Alexandre, Gladys

    2015-10-01

    Chemotaxis affords motile cells the ability to rapidly respond to environmental challenges by navigating cells to niches favoring growth. Such a property results from the activities of dedicated signal transduction systems on the motility apparatus, such as flagella, type IV pili, and gliding machineries. Once cells have reached a niche with favorable conditions, they often stop moving and aggregate into complex communities termed biofilms. An intermediate and reversible stage that precedes commitment to permanent adhesion often includes transient cell-cell contacts between motile cells. Chemotaxis signaling has been implicated in modulating the transient aggregation of motile cells. Evidence further indicates that chemotaxis-dependent transient cell aggregation events are behavioral responses to changes in metabolic cues that temporarily prohibit permanent attachment by maintaining motility and chemotaxis. This minireview discusses a few examples illustrating the role of chemotaxis signaling in the initiation of cell-cell contacts in bacteria moving via flagella, pili, or gliding.

  1. World, We Have Problems: Simulation for Large Complex, Risky Projects, and Events

    NASA Technical Reports Server (NTRS)

    Elfrey, Priscilla

    2010-01-01

    Prior to a spacewalk during the NASA STS/129 mission in November 2009, Columbia Broadcasting System (CBS) correspondent William Harwood reported astronauts, "were awakened again", as they had been the day previously. Fearing something not properly connected was causing a leak, the crew, both on the ground and in space, stopped and checked everything. The alarm proved false. The crew did complete its work ahead of schedule, but the incident reminds us that correctly connecting hundreds and thousands of entities, subsystems and systems, finding leaks, loosening stuck valves, and adding replacements to very large complex systems over time does not occur magically. Everywhere major projects present similar pressures. Lives are at - risk. Responsibility is heavy. Large natural and human-created disasters introduce parallel difficulties as people work across boundaries their countries, disciplines, languages, and cultures with known immediate dangers as well as the unexpected. NASA has long accepted that when humans have to go where humans cannot go that simulation is the sole solution. The Agency uses simulation to achieve consensus, reduce ambiguity and uncertainty, understand problems, make decisions, support design, do planning and troubleshooting, as well as for operations, training, testing, and evaluation. Simulation is at the heart of all such complex systems, products, projects, programs, and events. Difficult, hazardous short and, especially, long-term activities have a persistent need for simulation from the first insight into a possibly workable idea or answer until the final report perhaps beyond our lifetime is put in the archive. With simulation we create a common mental model, try-out breakdowns of machinery or teamwork, and find opportunity for improvement. Lifecycle simulation proves to be increasingly important as risks and consequences intensify. Across the world, disasters are increasing. We anticipate more of them, as the results of global warming

  2. Modelling of a Zonda wind event in a complex terrain region using WRF

    NASA Astrophysics Data System (ADS)

    Fernandez, R. P.; Cremades, P. G.; Lakkis, G.; Allende, D. G.; Santos, R.; Puliafito, S. E.

    2012-04-01

    The air quality modeling in a regional scale requires the coupling to Numerical Weather Prediction (NWP) models, mainly when a high spatial and temporal resolution is required, such as in those cases related to large pollutants emissions episodes or extreme weather events. The Weather Research and Forecasting (WRF) is a last generation NWP model which computes temperature, pressure, humidity and wind fields in high spatial and temporal resolution. In order to perform simulations in complex terrain regions, WRF must be locally configured to obtain a proper representation of the physical processes, and an independent validation must be performed, both under common and extreme conditions. Once the local configuration is obtained, a full atmospheric chemistry modeling can be performed by means of WRF-Chem. In this work a mesoescale event of Zonda wind (similar to Foehn and Chinook winds) affecting the topographically complex mountainous region of Mendoza (Argentina) on February 15th, 2007 is represented using WRF. The model results are compared to the Argentine National Weather Service (SMN) observations at "El Plumerillo" station (WMO #87418), showing a good performance. A description of the local model configuration and most important physical parameterizations selected for the simulations is given, including the improvement of the default resolution of land use and land cover (LULC) fields. The high resolution modeling domain considered is centered at the city of Mendoza (32° 53' South, 68° 50' West), it extends 200 km N/S × 160 km E/W and includes a 3-nested domain downscaling of 36, 12 and 4 km resolution, respectively. The results for the Zonda wind episode show a very good performance of the model both in spatial and temporal scales. The temporal dew point variation (the physical variable that best describes the Zonda wind) shows a good agreement with the measured values, with a sharp decrease of 20 °C (from 16 °C to -4 °C) in 3 hours. A full 3-D regional

  3. Numerical investigations with WRF about atmospheric features leading to heavy precipitation and flood events over the Central Andes' complex topography

    NASA Astrophysics Data System (ADS)

    Zamuriano, Marcelo; Brönnimann, Stefan

    2017-04-01

    It's known that some extremes such as heavy rainfalls, flood events, heatwaves and droughts depend largely on the atmospheric circulation and local features. Bolivia is no exception and while the large scale dynamics over the Amazon has been largely investigated, the local features driven by the Andes Cordillera and the Altiplano is still poorly documented. New insights on the regional atmospheric dynamics preceding heavy precipitation and flood events over the complex topography of the Andes-Amazon interface are added through numerical investigations of several case events: flash flood episodes over La Paz city and the extreme 2014 flood in south-western Amazon basin. Large scale atmospheric water transport is dynamically downscaled in order to take into account the complex topography forcing and local features as modulators of these events. For this purpose, a series of high resolution numerical experiments with the WRF-ARW model is conducted using various global datasets and parameterizations. While several mechanisms have been suggested to explain the dynamics of these episodes, they have not been tested yet through numerical modelling experiments. The simulations captures realistically the local water transport and the terrain influence over atmospheric circulation, even though the precipitation intensity is in general unrealistic. Nevertheless, the results show that Dynamical Downscaling over the tropical Andes' complex terrain provides useful meteorological data for a variety of studies and contributes to a better understanding of physical processes involved in the configuration of these events.

  4. Complex epithelial remodeling underlie the fusion event in early fetal development of the human penile urethra.

    PubMed

    Shen, Joel; Overland, Maya; Sinclair, Adriane; Cao, Mei; Yue, Xuan; Cunha, Gerald; Baskin, Laurence

    We recently described a two-step process of urethral plate canalization and urethral fold fusion to form the human penile urethra. Canalization ("opening zipper") opens the solid urethral plate into a groove, and fusion ("closing zipper") closes the urethral groove to form the penile urethra. We hypothesize that failure of canalization and/or fusion during human urethral formation can lead to hypospadias. Herein, we use scanning electron microscopy (SEM) and analysis of transverse serial sections to better characterize development of the human fetal penile urethra as contrasted to the development of the human fetal clitoris. Eighteen 7-13 week human fetal external genitalia specimens were analyzed by SEM, and fifteen additional human fetal specimens were sectioned for histologic analysis. SEM images demonstrate canalization of the urethral/vestibular plate in the developing male and female external genitalia, respectively, followed by proximal to distal fusion of the urethral folds in males only. The fusion process during penile development occurs sequentially in multiple layers and through the interlacing of epidermal "cords". Complex epithelial organization is also noted at the site of active canalization. The demarcation between the epidermis of the shaft and the glans becomes distinct during development, and the epithelial tag at the distal tip of the penile and clitoral glans regresses as development progresses. In summary, SEM analysis of human fetal specimens supports the two-zipper hypothesis of formation of the penile urethra. The opening zipper progresses from proximal to distal along the shaft of the penis and clitoris into the glans in identical fashion in both sexes. The closing zipper mechanism is active only in males and is not a single process but rather a series of layered fusion events, uniquely different from the simple fusion of two epithelial surfaces as occurs in formation of the palate and neural tube.

  5. Complex epithelial remodeling underlie the fusion event in early fetal development of the human penile urethra

    PubMed Central

    Sinclair, Adriane; Cao, Mei; Yue, Xuan; Cunha, Gerald; Baskin, Laurence

    2016-01-01

    We recently described a two-step process of urethral plate canalization and urethral fold fusion to form the human penile urethra. Canalization (“opening zipper”) opens the solid urethral plate into a groove, and fusion (“closing zipper”) closes the urethral groove to form the penile urethra. We hypothesize that failure of canalization and/or fusion during human urethral formation can lead to hypospadias. Herein, we use scanning electron microscopy (SEM) and analysis of transverse serial sections to better characterize development of the human fetal penile urethra as contrasted to the development of the human fetal clitoris. Eighteen 7-13 week human fetal external genitalia specimens were analyzed by SEM, and fifteen additional human fetal specimens were sectioned for histologic analysis. SEM images demonstrate canalization of the urethral/vestibular plate in the developing male and female external genitalia, respectively, followed by proximal to distal fusion of the urethral folds in males only. The fusion process during penile development occurs sequentially in multiple layers and through the interlacing of epidermal “cords”. Complex epithelial organization is also noted at the site of active canalization. The demarcation between the epidermis of the shaft and the glans becomes distinct during development, and the epithelial tag at the distal tip of the penile and clitoral glans regresses as development progresses. In summary, SEM analysis of human fetal specimens supports the two-zipper hypothesis of formation of the penile urethra. The opening zipper progresses from proximal to distal along the shaft of the penis and clitoris into the glans in identical fashion in both sexes. The closing zipper mechanism is active only in males and is not a single process but rather a series of layered fusion events, uniquely different from the simple fusion of two epithelial surfaces as occurs in formation of the palate and neural tube. PMID:27397682

  6. Offside Decisions by Expert Assistant Referees in Association Football: Perception and Recall of Spatial Positions in Complex Dynamic Events

    ERIC Educational Resources Information Center

    Gilis, Bart; Helsen, Werner; Catteeuw, Peter; Wagemans, Johan

    2008-01-01

    This study investigated the offside decision-making process in association football. The first aim was to capture the specific offside decision-making skills in complex dynamic events. Second, we analyzed the type of errors to investigate the factors leading to incorrect decisions. Federation Internationale de Football Association (FIFA; n = 29)…

  7. Inverse analysis of thermal conductivities in transient non-homogeneous and non-linear heat conductions using BEM based on complex variable differentiation method

    NASA Astrophysics Data System (ADS)

    Yu, XiaoChun; Bai, YuGuang; Cui, Miao; Gao, XiaoWei

    2013-05-01

    This paper presents a new inverse analysis approach to sensitivity analysis and material property identification in transient non-homogeneous and non-linear heat conduction Boundary Element Method (BEM) analysis based on Complex Variable Differentiation Method (CVDM). In this approach, the material properties are taken as the optimization variables, and the sensitivity coefficients are computed by CVDM. The advantages of using CVDM are that the computation of partial derivatives of an implicit function is reduced to function calculation in a complex domain, and the parameter sensitivity coefficients can be determined in a more accurate way than the traditional Finite Difference Method (FDM). Based on BEM and CVDM in evaluation of the sensitivity matrix of heat flux, the parameter such as thermal conductivity can be accurately identified. Six numerical examples are given to demonstrate the potential of the proposed approach. The results indicate that the presented method is efficient for identifying the thermal conductivity with single or multiple parameters.

  8. Transient Astronomical Events as Inspiration Sources of Medieval Art. III: the 13th and 14th Centuries, and the case of the French "Ordre de L'Étoile"

    NASA Astrophysics Data System (ADS)

    Bònoli, F.; Incerti, M.; Polcaro, V. F.

    2015-05-01

    Going ahead in our long-term project of analysis of the role of transient astronomical events as inspirational sources of medieval art, we extend our interest towards the 13th and 14th centuries, epochs of strong changes either in society, art or science. It is our aim to verify if the relationship we found in the 11th century between the number of artworks where a star is represented, and astonishing transient astronomical events was, in this new situation, still valid. Moreover, in order to check the influence of astronomical events on the 14th-century social and cultural environment, we focus on the case of the Ordre de l'Étoile, a chivalrous society founded by John II of France (Jan le Bon, roi de France) at the end of 1351, looking in ancient chronicles for some relevant contemporary astronomical event as an inspiration source for the "star" in the Order's name, in the garb of its knights and in its motto.

  9. Determination of the transient period of the EIS complex and investigation of the suppression of blood glucose levels by L-arabinose in healthy adults.

    PubMed

    Shibanuma, Kiyoshi; Degawa, Yoko; Houda, Koichi

    2011-09-01

    L-Arabinose uncompetitively inhibits intestinal sucrase by forming an enzyme-inhibitor-substrate (EIS) complex. The transient period of the EIS complex affects the time span of inhibition. We determined the apparent transient period of the EIS complex of sucrase, L-arabinose, and sucrose both in vitro and in humans. Intestinal acetone powder (a source of sucrase), L-arabinose, and sucrose were mixed and injected into a dialysis membrane that was placed in a sucrose solution. The production rate of D-glucose and the release rate of L-arabinose from sucrase were determined. We also investigated the suppression of blood glucose levels by L-arabinose in 21 healthy volunteers. Sucrose (40 g) was ingested with or without L-arabinose (2 g), then blood glucose values were measured, which returned to steady-state conditions within 2 h. Volunteers were then given 90 g of commercial adzuki bean jelly containing 40 g sucrose as the sucrose load, and blood glucose values were measured again. Addition of L-arabinose reduced the production rate of D -glucose compared to the rates measured in the absence of L-arabinose for several hours in vitro. L-Arabinose was released at a lower rate in the presence of sucrose than in its absence. Blood glucose values measured 2 h after sucrose was given with L -arabinose were significantly lower than those measured when L-arabinose was not given (Δ change in maximum value: with L-arabinose, 53.8 ± 19.7 mg/dL; without L-arabinose, 65.0 ± 17.7 mg/dL). The EIS complex of sucrase-L -arabinose-sucrose was maintained for several hours both in vitro and in humans.

  10. An event generator for simulations of complex β-decay experiments

    NASA Astrophysics Data System (ADS)

    Jordan, D.; Algora, A.; Tain, J. L.

    2016-08-01

    This article describes a Monte Carlo event generator for the design, optimization and performance characterization of beta decay spectroscopy experimental set-ups. The event generator has been developed within the Geant4 simulation architecture and provides new features and greater flexibility in comparison with the current available decay generator.

  11. Deciphering landscape complexity to predict (non)linear responses to extreme climatic events

    USDA-ARS?s Scientific Manuscript database

    Extreme events are increasing in frequency and magnitude for many landscapes globally. Ecologically, most of the focus on extreme climatic events has been on effects of either short-term pulses (floods, freezes) or long-term drought. Multi-year increases in precipitation are also occurring with litt...

  12. Partners in adversity: II. Measurement and description of stressful event sequences ('complexes').

    PubMed

    Miller, P M; Surtees, P G

    1993-01-01

    Three groups of married women were studied with each defined by their experience of a different stressful incident (the target event). In the first (the Coronary Group), the husband had suffered a non-fatal myocardial infarction whilst in the second (the Bereaved Group), he had recently died. In the third (the Refuge Group) the subject had just entered a refuge run by Women's Aid in order to flee from her husband. This paper concentrates on the description and measurement of the sequence of these experiences and of others occurring within the same study time. The Bedford College core rating scheme together with other ratings were applied. In the Coronary group, the target event was rated as a severe threat in 46.9% of cases, and also rated as being of uncertain outcome and hopeless. Over one quarter of the sample received other ratings such as subject-focused and choice of action. Virtually all the bereavements were rated severe threat, loss, hopeless and subject-focused. The refuge target events were mostly rated of only moderate threat but differed widely on other characteristics. In the 6 months prior to the target event, other severe events tended to occur most frequently to the Refuge group and least frequently to the Coronary group. However, these other severe events were mostly connected with the target event and what had lead up to it. Issues concerning the measurement of the principal study events and the other stressors experienced are discussed.

  13. Responsive metal complexes: a click-based "allosteric scorpionate" complex permits the detection of a biological recognition event by EPR/ENDOR spectroscopy.

    PubMed

    Tamanini, Emiliano; Rigby, Stephen E J; Motevalli, Majid; Todd, Matthew H; Watkinson, Michael

    2009-01-01

    Chemical sensing is a mature field, and many effective sensors for small anions and cations have been devised. Metal complexes have been used widely for this purpose, but there are fewer reports of their use in the detection of organic and biological analytes. To date metal complexes have been used in sensing via the direct displacement of a pre-existing ligand by an analyte, or by an adventitious complementarity between the complex and analyte. These strategies do not permit a general approach to the sensing of biological molecules with metal complexes because of the demands to engineer molecular recognition into the complex architecture. We describe a fundamentally new approach to this field-the "allosteric scorpionate" metal complex. The binding partner of a biological analyte is attached to a scorpionate ligand on a metal complex, remote from the metal centre. Binding of the analyte causes a change in the primary coordination sphere at the metal, thereby revealing the presence of the biological molecule. We show that azamacrocyclic complexes with a triazole scorpion ligand may be easily assembled with the [3+2] Huisgens 'click' cycloaddition. We demonstrate the synthesis of a biotin-functionalised cyclam derivative using this methodology. This, and our previously communicated zinc sensor, are to the best of our knowledge the first examples of a triazole being employed as a scorpion ligand on an azamacrocycle. Coordination by the triazole to the metal is perturbed by the binding of avidin to the pendant ligand. This event can be sensitively detected with EPR spectroscopy, and the details of the coordination change probed with ENDOR spectroscopy, confirming the loss of the axial triazole nitrogen donor upon binding to avidin. This represents the first metal complex where remote, 'allosteric' coordination of an analyte has been shown to cause a change in the primary coordination sphere of the metal. Since the synthesis is modular and straightforward, other

  14. A comparison of the three isoforms of the light-harvesting complex II using transient absorption and time-resolved fluorescence measurements.

    PubMed

    Palacios, Miguel A; Standfuss, Joerg; Vengris, Mikas; van Oort, Bart F; van Stokkum, Ivo H M; Kühlbrandt, Werner; van Amerongen, Herbert; van Grondelle, Rienk

    2006-06-01

    In this article we report the characterization of the energy transfer process in the reconstituted isoforms of the plant light-harvesting complex II. Homotrimers of recombinant Lhcb1 and Lhcb2 and monomers of Lhcb3 were compared to native trimeric complexes. We used low-intensity femtosecond transient absorption (TA) and time-resolved fluorescence measurements at 77 K and at room temperature, respectively, to excite the complexes selectively in the chlorophyll b absorption band at 650 nm with 80 fs pulses and on the high-energy side of the chlorophyll a absorption band at 662 nm with 180 fs pulses. The subsequent kinetics was probed at 30-35 different wavelengths in the region from 635 to 700 nm. The rate constants for energy transfer were very similar, indicating that structurally the three isoforms are highly homologous and that probably none of them play a more significant role in light-harvesting and energy transfer. No signature has been found in the transient absorption measurements at 77 K for Lhcb3 which might suggest that this protein acts as a relative energy sink of the excitations in heterotrimers of Lhcb1/Lhcb2/Lhcb3. Minor differences in the amplitudes of some of the rate constants and in the absorption and fluorescence properties of some pigments were observed, which are ascribed to slight variations in the environment surrounding some of the chromophores depending on the isoform. The decay of the fluorescence was also similar for the three isoforms and multi-exponential, characterized by two major components in the ns regime and a minor one in the ps regime. In agreement with previous transient absorption measurements on native LHC II complexes, Chl b --> Chl a energy transfer exhibited very fast channels but at the same time a slow component (ps). The Chls absorbing at around 660 nm exhibited both fast energy transfer which we ascribe to transfer from 'red' Chl b towards 'red' Chl a and slow transfer from 'blue' Chl a towards 'red' Chl a. The

  15. Dynamic Topology and Spatio-Temporal Complexity of Stick-Slip Events in Natural Faulted Westerly Granite

    NASA Astrophysics Data System (ADS)

    Ghaffari, H.; Thompson, B. D.; Young, R.

    2011-12-01

    The patterns of acoustic events prior to and after a stick-slip event are transformed to complex networks and the characteristics of the networks are measured. The patterns are the result of acoustic emission monitoring through loading a cylindrical sample of Westerly granite containing a natural fault [1].Two approaches are implemented in construction of the networks. In the first approach the network is constructed based on nearest neighbour events while the interactions of the main fault with the second and third faults are inspected through analyzing the spatial communities of the networks. The second approach uses a network method on phase space of time series (i.e., constructing a smooth manifold) obtained from the waveforms of over occurrence rank of events [2]. With the later implementation, we characterize the source mechanism of events while we compare the characteristics of the obtained networks (i.e., motif distribution and eigenvector of Laplacian) with the inferred source mechanism from the inverse moment tensor approach. Our results show the correlation of motifs rank evolution with source mechanism. Furthermore, with respect to the shape of triangles (as well as stretching and folding) over spatial complex networks and based on the first approach, the 3 point nodes motif distributions are extended to consider possible statistical geometry of events. Thus, the spatio-temporal complexity and possible coupling of events in time and space in terms of network parameters is inferred. We compare our results with the recent analysis of networks motifs from pure shear rupture associated with sudden variation of contact strings [3]. Keyword:, Stick-sllip; Westerly granite, Acoustic Emission Patterns; Complex Networks, and Motifs Ref. [1] Thompson, B.D., D.A. Lockner and R.P. Young, Premonitory acoustic emissions and stick slip in natural and smooth faulted Westerly granite,J. Geophysical Research, Vol 114, B02205, doi: 10.1029/2008jb005753, 2009. [2] J. F

  16. Homologous Solar Events on 2011 January 27: Build-up and Propagation in a Complex Coronal Environment

    NASA Astrophysics Data System (ADS)

    Pick, M.; Stenborg, G.; Démoulin, P.; Zucca, P.; Lecacheux, A.

    2016-05-01

    In spite of the wealth of imaging observations at the extreme-ultraviolet (EUV), X-ray, and radio wavelengths, there are still relatively few cases where all of the imagery is available to study the full development of a coronal mass ejection (CME) event and its associated shock. The aim of this study is to contribute to the understanding of the role of the coronal environment in the development of CMEs and the formation of shocks, and their propagation. We have analyzed the interactions of a couple of homologous CME events with ambient coronal structures. Both events were launched in a direction far from the local vertical, and exhibited a radical change in their direction of propagation during their progression from the low corona into higher altitudes. Observations at EUV wavelengths from the Atmospheric Imaging Assembly instrument on board the Solar Dynamic Observatory were used to track the events in the low corona. The development of the events at higher altitudes was followed by the white-light coronagraphs on board the Solar and Heliospheric Observatory. Radio emissions produced during the development of the events were well recorded by the Nançay solar instruments. Thanks to their detection of accelerated electrons, the radio observations are an important complement to the EUV imaging. They allowed us to characterize the development of the associated shocks, and helped to unveil the physical processes behind the complex interactions between the CMEs and ambient medium (e.g., compression, reconnection).

  17. A computer code for multiphase all-speed transient flows in complex geometries. MAST version 1.0

    NASA Technical Reports Server (NTRS)

    Chen, C. P.; Jiang, Y.; Kim, Y. M.; Shang, H. M.

    1991-01-01

    The operation of the MAST code, which computes transient solutions to the multiphase flow equations applicable to all-speed flows, is described. Two-phase flows are formulated based on the Eulerian-Lagrange scheme in which the continuous phase is described by the Navier-Stokes equation (or Reynolds equations for turbulent flows). Dispersed phase is formulated by a Lagrangian tracking scheme. The numerical solution algorithms utilized for fluid flows is a newly developed pressure-implicit algorithm based on the operator-splitting technique in generalized nonorthogonal coordinates. This operator split allows separate operation on each of the variable fields to handle pressure-velocity coupling. The obtained pressure correction equation has the hyperbolic nature and is effective for Mach numbers ranging from the incompressible limit to supersonic flow regimes. The present code adopts a nonstaggered grid arrangement; thus, the velocity components and other dependent variables are collocated at the same grid. A sequence of benchmark-quality problems, including incompressible, subsonic, transonic, supersonic, gas-droplet two-phase flows, as well as spray-combustion problems, were performed to demonstrate the robustness and accuracy of the present code.

  18. Complex effusive events at Kilauea as documented by the GOES satellite and remote video cameras

    USGS Publications Warehouse

    Harris, A.J.L.; Thornber, C.R.

    1999-01-01

    GOES provides thermal data for all of the Hawaiian volcanoes once every 15 min. We show how volcanic radiance time series produced from this data stream can be used as a simple measure of effusive activity. Two types of radiance trends in these time series can be used to monitor effusive activity: (a) Gradual variations in radiance reveal steady flow-field extension and tube development. (b) Discrete spikes correlate with short bursts of activity, such as lava fountaining or lava-lake overflows. We are confident that any effusive event covering more than 10,000 m2 of ground in less than 60 min will be unambiguously detectable using this approach. We demonstrate this capability using GOES, video camera and ground-based observational data for the current eruption of Kilauea volcano (Hawai'i). A GOES radiance time series was constructed from 3987 images between 19 June and 12 August 1997. This time series displayed 24 radiance spikes elevated more than two standard deviations above the mean; 19 of these are correlated with video-recorded short-burst effusive events. Less ambiguous events are interpreted, assessed and related to specific volcanic events by simultaneous use of permanently recording video camera data and ground-observer reports. The GOES radiance time series are automatically processed on data reception and made available in near-real-time, so such time series can contribute to three main monitoring functions: (a) automatically alerting major effusive events; (b) event confirmation and assessment; and (c) establishing effusive event chronology.

  19. Transient 120,000-year response of the large regional flow system at Yucca Mountain, Nevada to complex cyclical variability in paleoclimate

    NASA Astrophysics Data System (ADS)

    Park, Y.; Schwartz, F. W.; Sudicky, E. A.; McLaren, R. G.; Huber, M.; Apted, M.

    2009-12-01

    A regional flow model is used to explore the transient behavior of a flow system at Yucca Mountain due to a significant variability in Pleistocene and Holocene climates. Simulations involve a 39 km slice of the Death Valley Flow System through Yucca Mountain toward the Amargosa Desert. The long time scale over which infiltration has changed (tens-of-thousands of years) is matched by the large physical extent of the flow system (many tens-of-kilometers). Paleo-infiltration rates were estimated using a juniper pollen percentage that extends from the last interglacial period (approximately 120 ka BP) to present. Flow and 14C transport simulations show that the flow system changes markedly as a function of paleoclimate. At the last glacial maximum (20 ka BP), the recharge to the flow system was about an order-of-magnitude higher than present and water table was more than 100 meters higher. With large basin time constants, flow is complicated because hydraulic heads at a given location reflect conditions of the past, but at another location the flow may reflect present conditions. This complexity is also manifested by processes that depend on flow, for example 14C transport. Without a model that accounts for the historical transients in recharge for at least the last 20,000 years, there is no simple way to deconvolve the 14C dates to explain patterns of flow.

  20. Event-based state estimation for a class of complex networks with time-varying delays: A comparison principle approach

    NASA Astrophysics Data System (ADS)

    Zhang, Wenbing; Wang, Zidong; Liu, Yurong; Ding, Derui; Alsaadi, Fuad E.

    2017-01-01

    The paper is concerned with the state estimation problem for a class of time-delayed complex networks with event-triggering communication protocol. A novel event generator function, which is dependent not only on the measurement output but also on a predefined positive constant, is proposed with hope to reduce the communication burden. A new concept of exponentially ultimate boundedness is provided to quantify the estimation performance. By means of the comparison principle, some sufficient conditions are obtained to guarantee that the estimation error is exponentially ultimately bounded, and then the estimator gains are obtained in terms of the solution of certain matrix inequalities. Furthermore, a rigorous proof is proposed to show that the designed triggering condition is free of the Zeno behavior. Finally, a numerical example is given to illustrate the effectiveness of the proposed event-based estimator.

  1. The complexity of atrial fibrillation newly diagnosed after ischemic stroke and transient ischemic attack: advances and uncertainties

    PubMed Central

    Cerasuolo, Joshua O.; Cipriano, Lauren E.; Sposato, Luciano A.

    2017-01-01

    Purpose of review Atrial fibrillation is being increasingly diagnosed after ischemic stroke and transient ischemic attack (TIA). Patient characteristics, frequency and duration of paroxysms, and the risk of recurrent ischemic stroke associated with atrial fibrillation detected after stroke and TIA (AFDAS) may differ from atrial fibrillation already known before stroke occurrence. We aim to summarize major recent advances in the field, in the context of prior evidence, and to identify areas of uncertainty to be addressed in future research. Recent findings Half of all atrial fibrillations in ischemic stroke and TIA patients are AFDAS, and most of them are asymptomatic. Over 50% of AFDAS paroxysms last less than 30 s. The rapid initiation of cardiac monitoring and its duration are crucial for its timely and effective detection. AFDAS comprises a heterogeneous mix of atrial fibrillation, possibly including cardiogenic and neurogenic types, and a mix of both. Over 25 single markers and at least 10 scores have been proposed as predictors of AFDAS. However, there are considerable inconsistencies across studies. The role of AFDAS burden and its associated risk of stroke recurrence have not yet been investigated. Summary AFDAS may differ from atrial fibrillation known before stroke in several clinical dimensions, which are important for optimal patient care strategies. Many questions remain unanswered. Neurogenic and cardiogenic AFDAS need to be characterized, as it may be possible to avoid some neurogenic cases by initiating timely preventive treatments. AFDAS burden may differ in ischemic stroke and TIA patients, with distinctive diagnostic and treatment implications. The prognosis of AFDAS and its risk of recurrent stroke are still unknown; therefore, it is uncertain whether AFDAS patients should be treated with oral anticoagulants. PMID:27984303

  2. Energy transfer pathways in light-harvesting complexes of purple bacteria as revealed by global kinetic analysis of two-dimensional transient spectra.

    PubMed

    Ostroumov, Evgeny E; Mulvaney, Rachel M; Anna, Jessica M; Cogdell, Richard J; Scholes, Gregory D

    2013-09-26

    Excited state dynamics in LH2 complexes of two purple bacterial species were studied by broad-band two-dimensional electronic spectroscopy. The optical response was measured in the 500-600 nm spectral region on the 0-400 fs time scale. Global target analysis of two-dimensional (2D) transient spectra revealed the main energy transfer pathways between carotenoid S2, 1Bu(-) and S1 states and bacteriochlorophyll Qx state. Global analysis ascertained the evolutionary and vibration-associated spectra, which also indicated the presence of a higher-lying vibrational level in the carotenoid S1 state. The estimation of the spectral overlap between the 1Bu(-) state and the Qx state indicated a significant contribution of the 1Bu(-) state to the overall S2-to-Qx excitation energy transfer.

  3. A femtosecond visible/visible and visible/mid-infrared transient absorption study of the light harvesting complex II.

    PubMed

    Stahl, Andreas D; Di Donato, Mariangela; van Stokkum, Ivo; van Grondelle, Rienk; Groot, Marie Louise

    2009-12-16

    Light harvesting complex II (LHCII) is the most abundant protein in the thylakoid membrane of higher plants and green algae. LHCII acts to collect solar radiation, transferring this energy mainly toward photosystem II, with a smaller amount going to photosystem I; it is then converted into a chemical, storable form. We performed time-resolved femtosecond visible pump/mid-infrared probe and visible pump/visible probe absorption difference spectroscopy on purified LHCII to gain insight into the energy transfer in this complex occurring in the femto-picosecond time regime. We find that information derived from mid-infrared spectra, together with structural and modeling information, provides a unique visualization of the flow of energy via the bottleneck pigment chlorophyll a604.

  4. Origin of chaotic transients in excitatory pulse-coupled networks

    NASA Astrophysics Data System (ADS)

    Zou, Hai-Lin; Li, Menghui; Lai, Choy-Heng; Lai, Ying-Cheng

    2012-12-01

    We develop an approach to understanding long chaotic transients in networks of excitatory pulse-coupled oscillators. Our idea is to identify a class of attractors, sequentially active firing (SAF) attractors, in terms of the temporal event structure of firing and receipt of pulses. Then all attractors can be classified into two groups: SAF attractors and non-SAF attractors. We establish that long transients typically arise in the transitional region of the parameter space where the SAF attractors are collectively destabilized. Bifurcation behavior of the SAF attractors is analyzed to provide a detailed understanding of the long irregular transients. Although demonstrated using pulse-coupled oscillator networks, our general methodology may be useful in understanding the origin of transient chaos in other types of networked systems, an extremely challenging problem in nonlinear dynamics and complex systems.

  5. Steady-state and transient polarized absorption spectroscopy of photosystem I complexes from the cyanobacteria Arthrospira platensis and Thermosynechococcus elongatus.

    PubMed

    Schlodder, Eberhard; Shubin, Vladimir V; El-Mohsnawy, Eithar; Roegner, Matthias; Karapetyan, Navassard V

    2007-06-01

    Core antenna and reaction centre of photosystem I (PS I) complexes from the cyanobacteria Arthrospira platensis and Thermosynechococcus elongatus have been characterized by steady-state polarized absorption spectroscopy, including linear dichroism (LD) and circular dichroism (CD). CD spectra and the second derivatives of measured 77 K CD spectra reveal the spectral components found in the polarized absorption spectra indicating the excitonic origin of the spectral forms of chlorophyll in the PS I complexes. The CD bands at 669-670(+), 673(+), 680(-), 683-685(-), 696-697(-), and 711(-) nm are a common feature of used PSI complexes. The 77 K CD spectra of the trimeric PS I complexes exhibit also low amplitude components around 736 nm for A. platensis and 720 nm for T. elongatus attributed to red-most chlorophylls. The LD measurements indicate that the transition dipole moments of the red-most states are oriented parallel to the membrane plane. The formation of P700(+)A(1)(-) or (3)P700 was monitored by time-resolved difference absorbance and LD spectroscopy to elucidate the spectral properties of the PS I reaction centre. The difference spectra give strong evidence for the delocalization of the excited singlet states in the reaction centre. Therefore, P700 cannot be considered as a dimer but should be regarded as a multimer of the six nearly equally coupled reaction centre chlorophylls in accordance with structure-based calculations. On the basis of the results presented in this work and earlier work in the literature it is concluded that the triplet state is localized most likely on P(A), whereas the cation is localized most likely on P(B).

  6. Teaching Tacting of Private Events Based on Public Accompaniments: Effects of Contingencies, Audience Control, and Stimulus Complexity.

    PubMed

    Stocco, Corey S; Thompson, Rachel H; Hart, John M

    2014-06-01

    Our current understanding of the role of private events in the science of behavior is based largely on Skinner's natural science interpretation of private events. Skinner described public accompaniments as one source of control for a verbal community to differentially reinforce verbal behavior regarding private events. In this study, we developed an experimental analogue to study variables influencing tacting of private events. The participant had exclusive access to one set of stimuli (the private stimuli), and the experimenter attempted to teach tacts for private stimuli based on their correspondence with public stimuli accessible to both the experimenter and participant. Results of experiments 1 and 2 demonstrated that reports of private stimuli were a function of degree of public-private correspondence, reinforcement contingency, and audience control. In some cases, we encountered reports controlled exclusively by public stimuli. Results of experiment 3 showed that public control was less likely when public stimuli were more complex and the experimenter had a unique behavioral history with respect to those stimuli that was not shared by the learner. The orderly patterns of data obtained suggest that analogue arrangements might be a useful, and even necessary, starting point for experimental investigations of how private events may enter into the analysis of behavior.

  7. Prediction of the most extreme rainfall events in the South American Andes: A statistical forecast based on complex networks

    NASA Astrophysics Data System (ADS)

    Boers, Niklas; Bookhagen, Bodo; Barbosa, Henrique; Marwan, Norbert; Kurths, Jürgen; Marengo, Jose

    2015-04-01

    During the monsoon season, the subtropical Andes in South America are exposed to spatially extensive extreme rainfall events that frequently lead to flashfloods and landslides with severe socio-economic impacts. Since dynamical weather forecast has substantial problems with predicting the most extreme events (above the 99th percentile), alternative forecast methods are called for. Based on complex network theory, we developed a general mathematical framework for statistical prediction of extreme events in significantly interrelated time series. The key idea of our approach is to make the internal synchronization structure of extreme events mathematically accessible in terms of the topology of a network which is constructed from measuring the synchronization of extreme events at different locations. The application of our method to high-spatiotemporal resolution rainfall data (TRMM 3B42) reveals a migration pattern of large convective systems from southeastern South America towards the Argentinean and Bolivian Andes, against the direction of the northwesterly low-level moisture flow from the Amazon Basin. Once these systems reach the Andes, they lead to spatially extensive extreme events up to elevations above 4000m, leading to substantial risks of associated natural hazards. Based on atmospheric composites, we could identify an intricate interplay of frontal systems approaching from the South, low-level moisture flow from the Amazon Basin to the North, and the Andean orography as responsible climatic mechanism. These insights allow to formulate a simple forecast rule predicting 60% (90% during El Niño conditions) of extreme rainfall events at the eastern slopes of the subtropical Andes. The rule can be computed from readily available rainfall and pressure data and is already being tested by local institutions for disaster preparation.

  8. Structural dynamics of nitrosylruthenium isomeric complexes studied with steady-state and transient pump-probe infrared spectroscopies

    NASA Astrophysics Data System (ADS)

    Zhao, Yan; Yang, Fan; Wang, Jianru; Yu, Pengyun; Pan, Huifen; Wang, Hongfei; Wang, Jianping

    2016-09-01

    The characteristic nitrosyl stretching (NO) in the region of 1800-1900 cm- 1 was used to study the geometric and ligand effect on two nitrosylruthenium complexes, namely [Ru(OAc)(2QN)2NO] (QN = 2-chloro-8-quinolinol (H2cqn) or QN = 2-methyl-8-quinolinol (H2mqn)). The NO stretching frequency (νNO) was found in the following order: νcis-1 (2cqn) > νcis-2 (2cqn) > νcis-1 (2mqn) > νtrans (2mqn). The results exhibited a spectral sensitivity of the NO mode to both charge distribution and ligand arrangement, which was supported by ab initio computations and natural bond orbital (NBO) analyses. Further, the vibrational population of the vibrationally excited NO stretching mode was found to relax on the order of 7-10 ps, showing less than 30% variation from one isomer to another, which were explained on the basis of NO local structures and solute-solvent interactions in these isomeric nitrosylruthenium complexes.

  9. Using rain-on-snow events to evaluate the quality of bias correction to represent complex inter-variable dependencies

    NASA Astrophysics Data System (ADS)

    Rössler, Ole; Bosshard, Thomas; Weingartner, Rolf

    2016-04-01

    A key issue for adaptation planning is the information of projections about changes of extremes. Climate projections of meteorological extremes and their downscaling are a challenge on their own. Yet - at least in hydrology - meteorological extremes are not necessarily hydrological extremes. These can also result from a sequence of days with only moderate meteorological conditions, too. This sequences are called "storylines". In climate change impact assess studies it is relevant to know, whether these meteorological storylines are represented in regional climate models, and how well can bias correction preserve or improve the representation. One storyline leading to hydrological extremes are rain-on-snow events, and more specifically rain-on-snowfall events. These events challenge the regional climate model and the bias correction in terms of representing absolute values and inter-variable dependences. This study makes use of the rain-on-snow-storylines to evaluate the performance of regional climate models and a bias correction method in reproducing complex inter-variable dependencies. At first, we applied a hydrological model to a mesoscale catchment in Switzerland that is known to be effected by rain-on-snow events. At second, the ERA-Interim driven regional climate model RCA4.5 - developed at SMHI - with a spatial resolution of 0.11 * 0.11 degree was used to drive the hydrological model. At third, bias-correction of the RCM was done applying the distribution based scaling (DBS) bias-correction method (Yang et al., 2010) developed at the SMHI. The bias-corrected data then also served as driving input data to the hydrological model. Based on the simulated runoff, as well as simulated precipitation, temperature, and snow pack data, an algorithm to detect rain-on-snow events was applied. Finally, the presence or absents of rain-on-snow events for the three different climate input data, ERA.RCA4.5, DBS corrected ERA.RC4 and observed climate, are evaluated within

  10. The Development of Mental Models for Auditory Events: Relational Complexity and Discrimination of Pitch and Duration

    ERIC Educational Resources Information Center

    Stevens, Catherine; Gallagher, Melinda

    2004-01-01

    This experiment investigated relational complexity and relational shift in judgments of auditory patterns. Pitch and duration values were used to construct two-note perceptually similar sequences (unary relations) and four-note relationally similar sequences (binary relations). It was hypothesized that 5-, 8- and 11-year-old children would perform…

  11. Dynamic studies of H-Ras•GTPγS interactions with nucleotide exchange factor Sos reveal a transient ternary complex formation in solution

    PubMed Central

    Vo, Uybach; Vajpai, Navratna; Embrey, Kevin J.; Golovanov, Alexander P.

    2016-01-01

    The cycling between GDP- and GTP- bound forms of the Ras protein is partly regulated by the binding of Sos. The structural/dynamic behavior of the complex formed between activated Sos and Ras at the point of the functional cycle where the nucleotide exchange is completed has not been described to date. Here we show that solution NMR spectra of H-Ras∙GTPγS mixed with a functional fragment of Sos (SosCat) at a 2:1 ratio are consistent with the formation of a rather dynamic assembly. H-Ras∙GTPγS binding was in fast exchange on the NMR timescale and retained a significant degree of molecular tumbling independent of SosCat, while SosCat also tumbled largely independently of H-Ras. Estimates of apparent molecular weight from both NMR data and SEC-MALS revealed that, at most, only one H-Ras∙GTPγS molecule appears stably bound to Sos. The weak transient interaction between Sos and the second H-Ras∙GTPγS may provide a necessary mechanism for complex dissociation upon the completion of the native GDP → GTP exchange reaction, but also explains measurable GTP → GTP exchange activity of Sos routinely observed in in vitro assays that use fluorescently-labelled analogs of GTP. Overall, the data presents the first dynamic snapshot of Ras functional cycle as controlled by Sos. PMID:27412770

  12. A new multi-frequency approach based on Padé approximants for the treatment of transient dynamics problems with the variational theory of complex rays

    NASA Astrophysics Data System (ADS)

    Rouzaud, C.; Gatuingt, F.; Hervé, G.; Dorival, O.

    2017-03-01

    Frequency-based methods were set up in order to circumvent the limits of classical finite element methods in fast dynamic simulations due to discretizations. In this approach the dynamic loading was shifted in the frequency domain by FFT, then treated by the Variational Theory of Complex Rays, and then the time response was reconstructed through an IFFT. This strategy proved to be very efficient due to the CPU VTCR very low cost. However in the case of a large loading spectrum this frequency-by-frequency approach could seriously degrade the computational performances of the strategy. This paper addresses this point by proposing the use of Padé approximants in order to limit the number of frequencies at which the response should be calculated. Padé approximation is applied to the overall VTCR system based on its frequency dependency. Finally, as simulations on a simple academic case and on a civil engineering structure show, this method is found to be very efficient for interpolating the frequency response functions of a complex structure. This is a key point to preserve the efficiency of the complete VTCR strategy for transient dynamic problems.

  13. Imaging ultrafast excited state pathways in transition metal complexes by X-ray transient absorption and scattering using X-ray free electron laser source.

    PubMed

    Chen, Lin X; Shelby, Megan L; Lestrange, Patrick J; Jackson, Nicholas E; Haldrup, Kristoffer; Mara, Michael W; Stickrath, Andrew B; Zhu, Diling; Lemke, Henrik; Chollet, Matthieu; Hoffman, Brian M; Li, Xiaosong

    2016-12-16

    This report will describe our recent studies of transition metal complex structural dynamics on the fs and ps time scales using an X-ray free electron laser source, Linac Coherent Light Source (LCLS). Ultrafast XANES spectra at the Ni K-edge of nickel(ii) tetramesitylporphyrin (NiTMP) were measured for optically excited states at a timescale from 100 fs to 50 ps, providing insight into its sub-ps electronic and structural relaxation processes. Importantly, a transient reduced state Ni(i) (π, 3dx(2)-y(2)) electronic state is captured through the interpretation of a short-lived excited state absorption on the low-energy shoulder of the edge, which is aided by the computation of X-ray transitions for postulated excited electronic states. The observed and computed inner shell to valence orbital transition energies demonstrate and quantify the influence of the electronic configuration on specific metal orbital energies. A strong influence of the valence orbital occupation on the inner shell orbital energies indicates that one should not use the transition energy from 1s to other orbitals to draw conclusions about the d-orbital energies. For photocatalysis, a transient electronic configuration could influence d-orbital energies up to a few eV and any attempt to steer the reaction pathway should account for this to ensure that external energies can be used optimally in driving desirable processes. NiTMP structural evolution and the influence of the porphyrin macrocycle conformation on relaxation kinetics can be likewise inferred from this study.

  14. Imaging ultrafast excited state pathways in transition metal complexes by X-ray transient absorption and scattering using X-ray free electron laser source

    SciTech Connect

    Chen, Lin X.; Shelby, Megan L.; Lestrange, Patrick J.; Jackson, Nicholas E.; Haldrup, Kristoffer; Mara, Michael W.; Stickrath, Andrew B.; Zhu, Diling; Lemke, Henrik; Chollet, Matthieu; Hoffman, Brian M.; Li, Xiaosong

    2016-01-01

    This report will describe our recent studies of transition metal complex structural dynamics on the fs and ps time scales using an X-ray free electron laser source, Linac Coherent Light Source (LCLS). Ultrafast XANES spectra at the Ni K-edge of nickel(II) tetramesitylporphyrin (NiTMP) were successfully measured for optically excited state at a timescale from 100 fs to 50 ps, providing insight into its sub-ps electronic and structural relaxation processes. Importantly, a transient reduced state Ni(I) (π, 3dx2-y2) electronic state is captured through the interpretation of a short-lived excited state absorption on the low-energy shoulder of the edge, which is aided by the computation of X-ray transitions for postulated excited electronic states. The observed and computed inner shell to valence orbital transition energies demonstrate and quantify the influence of electronic configuration on specific metal orbital energies. A strong influence of the valence orbital occupation on the inner shell orbital energies indicates that one should not use the transition energy from 1s to other orbitals to draw conclusions about the d-orbital energies. For photocatalysis, a transient electronic configuration could influence d-orbital energies up to a few eV and any attempt to steer the reaction pathway should account for this to ensure that external energies can be used optimally in driving desirable processes. NiTMP structural evolution and the influence of the porphyrin macrocycle conformation on relaxation kinetics can be likewise inferred from this study.

  15. Incorporating Love- and Rayleigh-wave magnitudes, unequal earthquake and explosion variance assumptions and interstation complexity for improved event screening

    SciTech Connect

    Anderson, Dale N; Bonner, Jessie L; Stroujkova, Anastasia; Shumway, Robert

    2009-01-01

    Our objective is to improve seismic event screening using the properties of surface waves, We are accomplishing this through (1) the development of a Love-wave magnitude formula that is complementary to the Russell (2006) formula for Rayleigh waves and (2) quantifying differences in complexities and magnitude variances for earthquake and explosion-generated surface waves. We have applied the M{sub s} (VMAX) analysis (Bonner et al., 2006) using both Love and Rayleigh waves to events in the Middle East and Korean Peninsula, For the Middle East dataset consisting of approximately 100 events, the Love M{sub s} (VMAX) is greater than the Rayleigh M{sub s} (VMAX) estimated for individual stations for the majority of the events and azimuths, with the exception of the measurements for the smaller events from European stations to the northeast. It is unclear whether these smaller events suffer from magnitude bias for the Love waves or whether the paths, which include the Caspian and Mediterranean, have variable attenuation for Love and Rayleigh waves. For the Korean Peninsula, we have estimated Rayleigh- and Love-wave magnitudes for 31 earthquakes and two nuclear explosions, including the 25 May 2009 event. For 25 of the earthquakes, the network-averaged Love-wave magnitude is larger than the Rayleigh-wave estimate. For the 2009 nuclear explosion, the Love-wave M{sub s} (VMAX) was 3.1 while the Rayleigh-wave magnitude was 3.6. We are also utilizing the potential of observed variances in M{sub s} estimates that differ significantly in earthquake and explosion populations. We have considered two possible methods for incorporating unequal variances into the discrimination problem and compared the performance of various approaches on a population of 73 western United States earthquakes and 131 Nevada Test Site explosions. The approach proposes replacing the M{sub s} component by M{sub s} + a* {sigma}, where {sigma} denotes the interstation standard deviation obtained from the

  16. Horizontal Gene Transfers from Bacteria to Entamoeba Complex: A Strategy for Dating Events along Species Divergence

    PubMed Central

    Romero, Miguel; Ximenez, Cecilia

    2016-01-01

    Horizontal gene transfer has proved to be relevant in eukaryotic evolution, as it has been found more often than expected and related to adaptation to certain niches. A relatively large list of laterally transferred genes has been proposed and evaluated for the parasite Entamoeba histolytica. The goals of this work were to elucidate the importance of lateral gene transfer along the evolutionary history of some members of the genus Entamoeba, through identifying donor groups and estimating the divergence time of some of these events. In order to estimate the divergence time of some of the horizontal gene transfer events, the dating of some Entamoeba species was necessary, following an indirect dating strategy based on the fossil record of plausible hosts. The divergence between E. histolytica and E. nuttallii probably occurred 5.93 million years ago (Mya); this lineage diverged from E. dispar 9.97 Mya, while the ancestor of the latter separated from E. invadens 68.18 Mya. We estimated times for 22 transferences; the most recent occurred 31.45 Mya and the oldest 253.59 Mya. Indeed, the acquisition of genes through lateral transfer may have triggered a period of adaptive radiation, thus playing a major role in the evolution of the Entamoeba genus. PMID:27239333

  17. Palomar Transient Factory

    NASA Astrophysics Data System (ADS)

    Kulkarni, S.; Quimby, R.

    2010-12-01

    The Palomar Transient Factory (PTF) was designed to explicitly to chart the transient sky with a particular focus on events which lie in the nova-supernova gap. With its innovative two-telescope architecture it achieves both high cadence and large areal rate of coverage. PTF was commissioned during the summer of 2009. PTF is now finding an extragalactic transient every 20 minutes and a Galactic (strong) variable every 10 minutes. Spectroscopy undertaken at Keck and Palomar has allowed us: identify an emerging class of ultra-luminous supernovae, discover luminous red novae, undertake UV spectroscopy of Ia supernovae, discover supernovae powered by something other than Nickel-56, clarification of sub-classes of core collapse and thermo-nuclear explosions, map the systematics of core collapse supernovae, a trove of eclipsing binaries and many others.

  18. Investigation of Microphysical Parameters within Winter and Summer Type Precipitation Events over Mountainous [Complex] Terrain

    SciTech Connect

    Stalker, James R.; Bossert, James E.

    1997-12-31

    In this study we investigate complex terrain effects on precipitation with RAMS for both in winter and summer cases from a microphysical perspective. We consider a two dimensional east-west topographic cross section in New Mexico representative of the Jemez mountains on the west and the Sangre de Cristo mountains on the east. Located between these two ranges is the Rio Grande Valley. In these two dimensional experiments, variations in DSDs are considered to simulate total precipitation that closely duplicate observed precipitation.

  19. Regulation of CTnDOT Conjugative Transfer Is a Complex and Highly Coordinated Series of Events

    PubMed Central

    Waters, Jillian L.; Salyers, Abigail A.

    2013-01-01

    ABSTRACT CTnDOT is a 65-kb conjugative transposon that is found in Bacteroides spp., which are one of the more abundant members within the lower human gastrointestinal tract. CTnDOT encodes resistance to the antibiotics erythromycin and tetracycline (Tc). An interesting feature of CTnDOT is that exposure to low levels of Tc induces a cascade of events that ultimately results in CTnDOT conjugative transfer. However, Tc is apparently not a switch that activates transfer but rather a signal that appears to override a series of negative regulators that inhibit premature excision and transfer of CTnDOT. In this minireview, we summarize over 20 years of research that focused on elucidating the highly coordinated regulation of excision, mobilization, and transfer of CTnDOT. PMID:24169574

  20. CREB, AP‐1, ternary complex factors and MAP kinases connect transient receptor potential melastatin‐3 (TRPM3) channel stimulation with increased c‐Fos expression

    PubMed Central

    Rubil, Sandra; Rössler, Oliver G.

    2016-01-01

    Background and Purpose The rise in intracellular Ca2+ stimulates the expression of the transcription factor c‐Fos. Depending on the mode of entry of Ca2+ into the cytosol, distinct signal transducers and transcription factors are required. Here, we have analysed the signalling pathway connecting a Ca2+ influx via activation of transient receptor potential melastatin‐3 (TRPM3) channels with enhanced c‐Fos expression. Experimental Approach Transcription of c‐Fos promoter/reporter genes that were integrated into the chromatin via lentiviral gene transfer was analysed in HEK293 cells overexpressing TRPM3. The transcriptional activation potential of c‐Fos was measured using a GAL4‐c‐Fos fusion protein. Key Results The signalling pathway connecting TRPM3 stimulation with enhanced c‐Fos expression requires the activation of MAP kinases. On the transcriptional level, three Ca2+‐responsive elements, the cAMP‐response element and the binding sites for the serum response factor (SRF) and AP‐1, are essential for the TRPM3‐mediated stimulation of the c‐Fos promoter. Ternary complex factors are additionally involved in connecting TRPM3 stimulation with the up‐regulation of c‐Fos expression. Stimulation of TRPM3 channels also increases the transcriptional activation potential of c‐Fos. Conclusions and Implications Signalling molecules involved in connecting TRPM3 with the c‐Fos gene are MAP kinases and the transcription factors CREB, SRF, AP‐1 and ternary complex factors. As c‐Fos constitutes, together with other basic region leucine zipper transcription factors, the AP‐1 transcription factor complex, the results of this study explain TRPM3‐induced activation of AP‐1 and connects TRPM3 with the biological functions regulated by AP‐1. © 2015 The British Pharmacological Society PMID:26493679

  1. Complex rupture process of the March 19, 2013, Rudna mine (Poland) seismic event - local and regional view

    NASA Astrophysics Data System (ADS)

    Rudzinski, Lukasz; Cesca, Simone; Lizurek, Grzegorz

    2015-04-01

    On March 19th, 2013 a strong shallow induced seismic event struck a mining panel in the room-and-pillar Rudna copper mine, SE Poland. The event caused important damages at the mining tunnel and trapped 19 miners, which were safely rescued few hour later. Despite mining induced seismicity is frequent at this mine, the March 19 event was unusual because of its larger magnitude, its occurrence far from the mining stopes, and because it was accompanied by a strong hazardous rockburst. The mining inspections following the event verified the occurrence of a rockfall with tunnel floor uplift, but also recognized the presence of a faulting structure at the hypocentral location. The availability of three monitoring networks, including local and regional data, short-period and broadband seismometers, as well as surface and in-mine installation, give an optimal set up to determine rupture parameters and compare the performance and results from different installations. We perform waveform and spectral based analysis to infer source properties, with a particular interest to the determination of the rupture processes, using different moment tensor inversion techniques. Our results are surprisingly different, ranging from a dominant thrust mechanism, resolved at closest distances, to a collapse-type rupture, resolved at regional distances. We proof that a complex rupture model is needed to explain all observations and justify these discrepancies. The final scenario indicates that the rupture nucleated as a weaker thrust mechanism, along a pre-existing weakened surface, and continued in a more energetic collapse event. The local surface LUMINEOS network has the potential to resolve both subevents, but not using a standard moment tensor decomposition. We propose here a new moment tensor decomposition and an alternative moment tensor fitting procedure, which can be used to analyze the moment tensor of collapse sources.

  2. Transient osteoporosis.

    PubMed

    Korompilias, Anastasios V; Karantanas, Apostolos H; Lykissas, Marios G; Beris, Alexandros E

    2008-08-01

    Transient osteoporosis is characterized primarily by bone marrow edema. The disease most commonly affects the hip, knee, and ankle in middle-aged men. Its cause remains unknown. The hallmark that separates transient osteoporosis from other conditions presenting with a bone marrow edema pattern is its self-limited nature. Laboratory tests usually do not contribute to the diagnosis. Plain radiographs may reveal regional osseous demineralization. Magnetic resonance imaging is used primarily for early diagnosis and monitoring disease progression. Early differentiation from more aggressive conditions with long-term sequelae is essential to avoid unnecessary treatment. Clinical entities such as transient osteoporosis of the hip and regional migratory osteoporosis are spontaneously resolving conditions. However, early differential diagnosis and surgical treatment are crucial for the patient with osteonecrosis of the hip or knee.

  3. Bézier curve string method for the study of rare events in complex chemical systems

    NASA Astrophysics Data System (ADS)

    Bellucci, Michael A.; Trout, Bernhardt L.

    2014-08-01

    We present a new string method for finding the most probable transition pathway and optimal reaction coordinate in complex chemical systems. Our approach evolves an analytic parametric curve, known as a Bézier curve, to the most probable transition path between metastable regions in configuration space. In addition, we demonstrate that the geometric properties of the Bézier curve can be used to construct the optimal reaction coordinate near the most probable reaction path, and can further be used to devise a ranking vector capable of identifying precisely which collective variables are most important for governing the transition between metastable states. We discuss the algorithmic details of the Bézier curve string method, analyze its stability, accuracy and efficiency, and illustrate its capabilities using model potential energy functions. In particular, we use the degree elevation property of Bézier curves to develop an algorithm that adaptively learns the degree polynomial necessary to accurately represent the most probable transition path. Subsequently, we apply our method to the isomerization of alanine dipeptide, and demonstrate that the reaction coordinate obtained from the Bézier curve string method is in excellent agreement with the optimal reaction coordinate constructed from an aimless shooting and maximum likelihood procedure. Finally, we apply our method to a large complex system and study the homogenous nucleation of benzene from the melt. In these two examples, we illustrate that the ranking vector correctly identifies which collective variables govern these chemical transitions.

  4. Early Oligocene geomagnetic field behavior from ODP Site 1128: Complex records of short-period polarity events

    NASA Astrophysics Data System (ADS)

    Molina-Garza, R. S.; Fuller, M. D.

    2001-12-01

    At Site 1128, in the Great Australian Bight, Leg 182 of the Ocean Drilling Program recovered a thick (~350 m) section of Upper Eocene and Lower Oligocene marine calcareous clays. Shipboard measurements established a magnetostratigraphy that can unambiguously be correlated to chrons C13n to C10n of the global polarity time scale (GPTS), and a less complete record of chrons C17n to C15r (due to poor core recovery). Correlation to the GPTS is further supported by available biostratigraphic data. For the Lower Oligocene sequence, average sedimentation rate is estimated at ~4 cm/kyr. The sediments recovered thus allow to test for the completeness and reliability of the geomagnetic field polarity during the Early Oligocene. The original shipboard long-core measurements suggested the presence of additional short polarity events or geomagnetic field excursions during chrons C13n, C12r, C11r, and C11n. In order to examine the reliability of the record and the nature of possible short-polarity events, we obtained discrete samples from the entire sequence at ~1 m intervals, with a closer sample spacing in critical intervals (~10 cm). The natural remanence of these sediments is normally simple. After removing a small soft overprint, the magnetization decays towards the origin with distributed coercivities and distributed unblocking temperatures. Demagnetization behavior and other rock magnetic data indicate that the remanence resides primarily in a cubic phase such as magnetite or maghemite, with a small contribution from hematite. Discrete samples from chron C12r did not reproduce the long-core record for two of the supposed events, single samples suggest the presence of short events or cryptochrons near the base of both C13n and C12r, and multiple samples suggest the existence of short-period normal polarity events during C11r and near the top of C12r. The records of these events are, however, complex. Demagnetization results indicate that the magnetization consists of an

  5. Transient deformation in the Asal-Ghoubbet Rift (Djibouti) since the 1978 diking event: Is deformation controlled by magma supply rates?

    NASA Astrophysics Data System (ADS)

    Smittarello, D.; Grandin, R.; De Chabalier, J.-B.; Doubre, C.; Deprez, A.; Masson, F.; Socquet, A.; Saad, I. A.

    2016-08-01

    The Asal-Ghoubbet Rift (AG Rift) in Djibouti lies in the subaerial continuation of the Aden ridge system, thereby constituting a unique location to study rifting processes and mechanisms involved in continental breakup and oceanic spreading. Continually upgraded and expanded geodetic technology has been used to record the 1978 Asal rifting event and postdiking deformation. In light of recent results obtained for the Manda Hararo-Dabbahu rifting event (2005-2010), we propose that the horizontal and vertical geodetic data can be modeled with a double source, involving a dike-like inflation component aligned along the rift axis and a spherical pressure source located at midsegment below the Fieale caldera. By revisiting the codiking data, we propose that the reservoir below Fieale could have fed, at least partially, the 1978 injection and the contemporaneous Ardoukôba eruption and potentially induced local subsidence due to magma draining out of the central reservoir. As an alternative to previously proposed viscoelastic relaxation models, we reinterpret postdiking observations using a purely elastic rheology. We determine the relative contribution of a midsegment reservoir inflation and a dike-like opening component, together with their respective time evolutions. Our results suggest that interactions between steadily accumulating tectonic strain and temporal variations in melt supply to the shallow magma plumbing system below the AG Rift may entirely explain the geodetic observations and that viscoelastic deformation processes played a minor role in the 30 years following the 1978 rifting event.

  6. Complex Socio-Ecological Dynamics driven by extreme events in the Amazon

    NASA Astrophysics Data System (ADS)

    Pinho, P. F.

    2015-12-01

    Several years with extreme floods or droughts in the past decade have caused human suffering in remote communities of the Brazilian Amazon. Despite documented local knowledge and practices for coping with the high seasonal variability characteristic of the region's hydrology (e.g. 10m change in river levels between dry and flood seasons), and despite 'civil Defense' interventions by various levels of government, the more extreme years seem to have exceeded the coping capacity of the community. In this paper, we explore whether there is a real increase in variability, whether the community perceives that recent extreme events are outside the experience which shapes their responses to 'normal' levels of variability, and what science-based policy could contribute to greater local resilience. Hydrological analyses suggest that variability is indeed increasing, in line with expectations from future climate change. However, current measures of hydrological regimes do not predict years with social hardship very well. Interviewees in two regions are able to express their strategies for dealing with 'normal' variability very well, but also identify ways in which abnormal years exceed their ability to cope. Current Civil Defense arrangements struggle to deliver emergency assistance in a sufficiently timely and locally appropriate fashion. Combining these insights in the context of social-ecological change, we suggest how better integration of science, policy and local knowledge could improve resilience to future trends, and identify some contributions science could make into such an arrangement.

  7. The event-related brain potential as an index of attention allocation in complex displays

    NASA Technical Reports Server (NTRS)

    Wickens, C. D.; Heffley, E. F.; Kramer, A. F.; Donchin, E.

    1980-01-01

    The advantages of employing the event-related brain potential (ERP) in the assessment of allocation of attention in dynamic environments are discussed. Three experiments are presented in which the P300 component of the ERP is demonstrated to be a useful index of subjects' locus of attention. The first two experiments were concerned with the allocation of attention during discrete and continuous visual monitoring tasks. The results indicated that a P300 was elicited only by stimuli to which the subject had to attend in order to perform successfully the task. The third experiment was conducted to assess the sensitivity of P300 to the manner in which attention is allocated to different aspects of a display during the performance of a 3-dimensional target acquisition task. The amplitude of the P300 was found to reflect differences between two levels of workload, as well as the task relevance of the stimuli. The results of the experiments are discussed in terms of their utility in the evaluation of the design of man-machine systems as well as in the study of the allocation of attention in operational environments.

  8. The event-related brain potential as an index of attention allocation in complex displays

    NASA Technical Reports Server (NTRS)

    Wickens, C. D.; Heffley, E. F.; Kramer, A. F.; Donchin, E.

    1980-01-01

    The advantages of employing the event-related brain potential (ERP) in the assessment of allocation of attention in dynamic environments are discussed. Three experiments are presented in which the P300 component of the ERP is demonstrated to be a useful index of subjects' locus of attention. The first two experiments were concerned with the allocation of attention during discrete and continuous visual monitoring tasks. The results indicated that a P300 was elicited only by stimuli to which the subject had to attend in order to perform successfully the task. The third experiment was conducted to assess the sensitivity of P300 to the manner in which attention is allocated to different aspects of a display during the performance of a 3-dimensional target acquisition task. The amplitude of the P300 was found to reflect differences between two levels of workload, as well as the task relevance of the stimuli. The results of the experiments are discussed in terms of their utility in the evaluation of the design of man-machine systems as well as in the study of the allocation of attention in operational environments.

  9. Probing energy transfer events in the light harvesting complex 2 (LH2) of Rhodobacter sphaeroides with two-dimensional spectroscopy.

    PubMed

    Fidler, Andrew F; Singh, Ved P; Long, Phillip D; Dahlberg, Peter D; Engel, Gregory S

    2013-10-21

    Excitation energy transfer events in the photosynthetic light harvesting complex 2 (LH2) of Rhodobacter sphaeroides are investigated with polarization controlled two-dimensional electronic spectroscopy. A spectrally broadened pulse allows simultaneous measurement of the energy transfer within and between the two absorption bands at 800 nm and 850 nm. The phased all-parallel polarization two-dimensional spectra resolve the initial events of energy transfer by separating the intra-band and inter-band relaxation processes across the two-dimensional map. The internal dynamics of the 800 nm region of the spectra are resolved as a cross peak that grows in on an ultrafast time scale, reflecting energy transfer between higher lying excitations of the B850 chromophores into the B800 states. We utilize a polarization sequence designed to highlight the initial excited state dynamics which uncovers an ultrafast transfer component between the two bands that was not observed in the all-parallel polarization data. We attribute the ultrafast transfer component to energy transfer from higher energy exciton states to lower energy states of the strongly coupled B850 chromophores. Connecting the spectroscopic signature to the molecular structure, we reveal multiple relaxation pathways including a cyclic transfer of energy between the two rings of the complex.

  10. Probing energy transfer events in the light harvesting complex 2 (LH2) of Rhodobacter sphaeroides with two-dimensional spectroscopy

    SciTech Connect

    Fidler, Andrew F.; Singh, Ved P.; Engel, Gregory S.; Long, Phillip D.; Dahlberg, Peter D.

    2013-10-21

    Excitation energy transfer events in the photosynthetic light harvesting complex 2 (LH2) of Rhodobacter sphaeroides are investigated with polarization controlled two-dimensional electronic spectroscopy. A spectrally broadened pulse allows simultaneous measurement of the energy transfer within and between the two absorption bands at 800 nm and 850 nm. The phased all-parallel polarization two-dimensional spectra resolve the initial events of energy transfer by separating the intra-band and inter-band relaxation processes across the two-dimensional map. The internal dynamics of the 800 nm region of the spectra are resolved as a cross peak that grows in on an ultrafast time scale, reflecting energy transfer between higher lying excitations of the B850 chromophores into the B800 states. We utilize a polarization sequence designed to highlight the initial excited state dynamics which uncovers an ultrafast transfer component between the two bands that was not observed in the all-parallel polarization data. We attribute the ultrafast transfer component to energy transfer from higher energy exciton states to lower energy states of the strongly coupled B850 chromophores. Connecting the spectroscopic signature to the molecular structure, we reveal multiple relaxation pathways including a cyclic transfer of energy between the two rings of the complex.

  11. TP53 mutations are early events in chronic lymphocytic leukemia disease progression and precede evolution to complex karyotypes.

    PubMed

    Lazarian, Gregory; Tausch, Eugen; Eclache, Virginie; Sebaa, Amel; Bianchi, Vincent; Letestu, Remi; Collon, Jean-Francois; Lefebvre, Valerie; Gardano, Laura; Varin-Blank, Nadine; Soussi, Thierry; Stilgenbauer, Stephen; Cymbalista, Florence; Baran-Marszak, Fanny

    2016-10-15

    TP53 abnormalities lead to resistance to purine analogues and are found in over 40% of patients with refractory chronic lymphocytic leukemia (CLL). At diagnosis, no more than 5% of patients carry the 17p deletion, most cases harbour mutations within the other TP53 allele. The incidence of a TP53 mutation as the only alteration is approximately 5%, but this depends on the sensitivity of the technique. Recently, having a complex karyotype has been considered a strong adverse prognostic factor. However, there are no longitudinal studies simultaneously examining the presence of the 17p deletion, TP53 mutations and karyotype abnormalities. We conducted a retrospective longitudinal study of 31 relapsed/refractory CLL patients. Two to six blood samples per patient were analyzed, with a median follow-up of 8 years. In this report, we assessed the sequence of events of TP53 clonal evolution and correlated the presence of TP53 abnormalities to genetic instability during progression and treatment. Next-generation sequencing allowed the early detection of TP53 mutated clones and was able to be performed on a routine basis, demonstrating an excellent correlation between the Illumina and Ion Torrent technologies. We concluded that TP53 mutations are early events and precede clonal evolution to complex karyotypes. We strongly recommend the early and iterated detection of TP53 mutations in progressive cases.

  12. 990 and 1100 Ma Grenvillian tectonothermal events in the northern Oaxacan Complex, southern Mexico: roots of an orogen

    NASA Astrophysics Data System (ADS)

    Solari, L. A.; Keppie, J. D.; Ortega-Gutiérrez, F.; Cameron, K. L.; Lopez, R.; Hames, W. E.

    2003-04-01

    Inliers of ˜1.0-1.3 Ga rocks occur throughout Mexico and form the basement of the Oaxaquia microcontinent. In the northern part of the largest inlier in southern Mexico, rocks of the Oaxacan Complex consist of the following structural sequence of units (from bottom to top), which protolith ages are: (1) Huitzo unit: a 1012±12 Ma anorthosite-mangerite-charnockite-granite (AMCG) suite; (2) El Catrı´n unit: ≥1350 Ma orthogneiss migmatized at 1106±6 Ma; and (3) El Marquez unit: ≥1140 Ma para- and orthogneisses. These rocks were affected by two major tectonothermal events that are dated using U-Pb isotopic analyses of zircon: (a) the 1106±6 Ma Olmecan event produced a migmatitic or metamorphic differentiation banding folded by isoclinal folds; and (b) the 1004-978±3 Ma Zapotecan event produced at least two sets of structures: (Z1) recumbent, isoclinal, Class 1C/3 folds with gently NW-plunging fold axes that are parallel to mineral and stretched quartz lineations under granulite facies metamorphism; and (Z2) tight, upright, subhorizontal WNW- to NNE-trending folds accompanied by development of brown hornblende at upper amphibolite facies metamorphic conditions. Cooling through 500 °C at 977±12 Ma is documented by 40Ar/ 39Ar analyses of hornblende. Fold mechanisms operating in the northern Oaxacan Complex under Zapotecan granulite facies metamorphism include flexural and tangential-longitudinal strain accompanied by intense flattening and stretching parallel to the fold axes. Subsequent Phanerozoic deformation includes thrusting and upright folding under lower-grade metamorphic conditions. The Zapotecan event is widespread throughout Oaxaquia, and took crustal rocks to a depth of ˜25-30 km by orogenic crustal thickening, and is here designated as Zapotecan Orogeny. Modern analogues for Zapotecan granulite facies metamorphism and deformation occur in middle to lower crustal portion of subduction and collisional orogens. Contemporaneous tectonothermal events

  13. Long-term neurocognitive outcome and auditory event-related potentials after complex febrile seizures in children.

    PubMed

    Tsai, Min-Lan; Hung, Kun-Long; Tsan, Ying-Ying; Tung, William Tao-Hsin

    2015-06-01

    Whether prolonged or complex febrile seizures (FS) produce long-term injury to the hippocampus is a critical question concerning the neurocognitive outcome of these seizures. Long-term event-related evoked potential (ERP) recording from the scalp is a noninvasive technique reflecting the sensory and cognitive processes associated with attention tasks. This study aimed to investigate the long-term outcome of neurocognitive and attention functions and evaluated auditory event-related potentials in children who have experienced complex FS in comparison with other types of FS. One hundred and forty-seven children aged more than 6 years who had experienced complex FS, simple single FS, simple recurrent FS, or afebrile seizures (AFS) after FS and age-matched healthy controls were enrolled. Patients were evaluated with Wechsler Intelligence Scale for Children (WISC; Chinese WISC-IV) scores, behavior test scores (Chinese version of Conners' continuous performance test, CPT II V.5), and behavior rating scales. Auditory ERPs were recorded in each patient. Patients who had experienced complex FS exhibited significantly lower full-scale intelligence quotient (FSIQ), perceptual reasoning index, and working memory index scores than did the control group but did not show significant differences in CPT scores, behavior rating scales, or ERP latencies and amplitude compared with the other groups with FS. We found a significant decrease in the FSIQ and four indices of the WISC-IV, higher behavior rating scales, a trend of increased CPT II scores, and significantly delayed P300 latency and reduced P300 amplitude in the patients with AFS after FS. We conclude that there is an effect on cognitive function in children who have experienced complex FS and patients who developed AFS after FS. The results indicated that the WISC-IV is more sensitive in detecting cognitive abnormality than ERP. Cognition impairment, including perceptual reasoning and working memory defects, was identified in

  14. Evolutionary site-number changes of ribosomal DNA loci during speciation: complex scenarios of ancestral and more recent polyploid events.

    PubMed

    Rosato, Marcela; Moreno-Saiz, Juan C; Galián, José A; Rosselló, Josep A

    2015-11-16

    Several genome duplications have been identified in the evolution of seed plants, providing unique systems for studying karyological processes promoting diversification and speciation. Knowledge about the number of ribosomal DNA (rDNA) loci, together with their chromosomal distribution and structure, provides clues about organismal and molecular evolution at various phylogenetic levels. In this work, we aim to elucidate the evolutionary dynamics of karyological and rDNA site-number variation in all known taxa of subtribe Vellinae, showing a complex scenario of ancestral and more recent polyploid events. Specifically, we aim to infer the ancestral chromosome numbers and patterns of chromosome number variation, assess patterns of variation of both 45S and 5S rDNA families, trends in site-number change of rDNA loci within homoploid and polyploid series, and reconstruct the evolutionary history of rDNA site number using a phylogenetic hypothesis as a framework. The best-fitting model of chromosome number evolution with a high likelihood score suggests that the Vellinae core showing x = 17 chromosomes arose by duplication events from a recent x = 8 ancestor. Our survey suggests more complex patterns of polyploid evolution than previously noted for Vellinae. High polyploidization events (6x, 8x) arose independently in the basal clade Vella castrilensis-V. lucentina, where extant diploid species are unknown. Reconstruction of ancestral rDNA states in Vellinae supports the inference that the ancestral number of loci in the subtribe was two for each multigene family, suggesting that an overall tendency towards a net loss of 5S rDNA loci occurred during the splitting of Vellinae ancestors from the remaining Brassiceae lineages. A contrasting pattern for rDNA site change in both paleopolyploid and neopolyploid species was linked to diversification of Vellinae lineages. This suggests dynamic and independent changes in rDNA site number during speciation processes and a

  15. Long-term avoidance memory formation is associated with a transient increase in mushroom body synaptic complexes in leaf-cutting ants

    PubMed Central

    Falibene, Agustina; Roces, Flavio; Rössler, Wolfgang

    2015-01-01

    Long-term behavioral changes related to learning and experience have been shown to be associated with structural remodeling in the brain. Leaf-cutting ants learn to avoid previously preferred plants after they have proved harmful for their symbiotic fungus, a process that involves long-term olfactory memory. We studied the dynamics of brain microarchitectural changes after long-term olfactory memory formation following avoidance learning in Acromyrmex ambiguus. After performing experiments to control for possible neuronal changes related to age and body size, we quantified synaptic complexes (microglomeruli, MG) in olfactory regions of the mushroom bodies (MBs) at different times after learning. Long-term avoidance memory formation was associated with a transient change in MG densities. Two days after learning, MG density was higher than before learning. At days 4 and 15 after learning—when ants still showed plant avoidance—MG densities had decreased to the initial state. The structural reorganization of MG triggered by long-term avoidance memory formation clearly differed from changes promoted by pure exposure to and collection of novel plants with distinct odors. Sensory exposure by the simultaneous collection of several, instead of one, non-harmful plant species resulted in a decrease in MG densities in the olfactory lip. We hypothesize that while sensory exposure leads to MG pruning in the MB olfactory lip, the formation of long-term avoidance memory involves an initial growth of new MG followed by subsequent pruning. PMID:25904854

  16. Pulse radiolytic study of the oxidation reactions of uric acid in presence of bovine serum albumin. Evidence of possible complex formation in the transient state

    NASA Astrophysics Data System (ADS)

    Adhikari, S.; Joshi, R.; Gopinathan, C.

    1997-01-01

    The pulse radiolytic and spectrophotometric study of uric acid in presence of bovine serum albumin (BSA) has been carried out. In the spectrophotometric study there is no evidence for ground state interaction between BSA and uric acid. The oxidation reactions of uric acid in presence and absence of BSA employing CCl 3OO and Br radicals have been carried out. In a composition of equal concentration of uric acid and BSA, the CCl 3OO and Br radicals produce a transient absorption spectrum which show two peaks at 330 and 360 nm. The peak at 360 nm is ascribed due to weak complex formation between semioxidised BSA and uric acid radicals. The rate constant of CCl 3OO . radical with uric acid increases with the increase in BSA concentration which is explained as protection of BSA by uric acid from radical attack. The Br radical attacks uric acid and BSA in a manner similar to CCl 3OO radical. The bimolecular rate constants for the reaction of Br radical with BSA and uric acid have been found as 2.9 × 10 10 dm 3 mol -1 s -1 and 6.33 × 10 9 dm 3 mol -1 s -, respectively.

  17. Comparison of transient grating signals from spheroidene in an organic solvent and in pigment-protein complexes from Rhodobacter sphaeroides 2.4.1

    NASA Astrophysics Data System (ADS)

    Sugisaki, Mitsuru; Fujiwara, Masazumi; Kosumi, Daisuke; Fujii, Ritsuko; Nango, Mamoru; Cogdell, Richard J.; Hashimoto, Hideki

    2010-06-01

    The concurrent dynamics of the electronic excitation and vibronic oscillations of spheroidene have been investigated by means of the transient grating (TG) spectroscopy. The third-order optical responses of spheroidene in an organic solvent, in the LH2 light-harvesting antenna complexes, and in chromatophores have been compared in order to investigate the influence of the environment surrounding this photosynthetic pigment. Vibronic coherent oscillations with a period of several tens of femtosecond have been clearly observed superimposed on a slowly varying background, which reflects the electronic dynamics. The dynamics of the coherent oscillations have been analyzed by means of the wavelet analysis. Within our experimental accuracy, the decay times of the CC and CC stretching modes and CCH3 rocking mode of each specimen are very close. The experimental results have also been analyzed using a Brownian oscillator model. For these numerical calculations, the spectral density for the underdamped modes has been determined from the Raman spectrum of spheroidene. It was found that the low-frequency modes that reflect the influence of the protein environment can be approximated by the overdamped Brownian oscillator. The experimentally observed linear absorption spectra as well as the third-order optical responses, i.e., TG curves, are reproduced very well by these calculations. The close agreement between the experiments and calculations indicates that the Feynman-diagrammatic approach can be applied to express not only the internal conversion but also the intermolecular excitation energy-transfer processes. The vibronic decay rates of spheroidene in LH2 complexes and chromatophores are evaluated to be about 20% larger than in the organic solvent.

  18. Complex source mechanisms of mining-induced seismic events - implications for surface effects

    NASA Astrophysics Data System (ADS)

    Orlecka-Sikora, B.; Cesca, S.; Lasocki, S.; Rudzinski, L.; Lizurek, L.; Wiejacz, P.; Urban, P.; kozlowska, M.

    2012-04-01

    The seismicity of Legnica-Głogów Copper District (LGCD) is induced by mining activities in three mines: Lubin, Rudna and Polkowice-Sieroszowice. Ground motion caused by strong tremors might affect local infrastructure. "Żelazny Most" tailings pond, the biggest structure of this type in Europe, is here under special concern. Due to surface objects protection, Rudna Mine has been running ground motion monitoring for several years. From June 2010 to June 2011 unusually strong and extensive surface impact has been observed for 6 mining tremors induced in one of Rudna mining sections. The observed peak ground acceleration (PGA) for both horizontal and vertical component were in or even beyond 99% confidence interval for prediction. The aim of this paper is analyze the reason of such unusual ground motion. On the basis of registrations from Rudna Mine mining seismological network and records from Polish Seismological Network held by the Institute of Geophysics Polish Academy of Sciences (IGF PAN), the source mechanisms of these 6 tremors were calculated using a time domain moment tensor inversion. Furthermore, a kinematic analysis of the seismic source was performed, in order to determine the rupture planes orientations and rupture directions. These results showed that in case of the investigated tremors, point source models and shear fault mechanisms, which are most often assumed in mining seismology, are invalid. All analyzed events indicate extended sources with non-shear mechanism. The rapture planes have small dip angles and the rupture starts at the tremors hypocenter and propagates in the direction opposite to the plane dip. The tensional component plays here also big role. These source mechanisms well explain such observed strong ground motion, and calculated synthetic PGA values well correlates with observed ones. The relationship between mining tremors were also under investigation. All subsequent tremors occurred in the area of increased stress due to

  19. The Development of Narrative Productivity, Syntactic Complexity, Referential Cohesion and Event Content in Four- to Eight-Year-Old Finnish Children

    ERIC Educational Resources Information Center

    Mäkinen, Leena; Loukusa, Soile; Nieminen, Lea; Leinonen, Eeva; Kunnari, Sari

    2014-01-01

    This study focuses on the development of narrative structure and the relationship between narrative productivity and event content. A total of 172 Finnish children aged between four and eight participated. Their picture-elicited narrations were analysed for productivity, syntactic complexity, referential cohesion and event content. Each measure…

  20. The Development of Narrative Productivity, Syntactic Complexity, Referential Cohesion and Event Content in Four- to Eight-Year-Old Finnish Children

    ERIC Educational Resources Information Center

    Mäkinen, Leena; Loukusa, Soile; Nieminen, Lea; Leinonen, Eeva; Kunnari, Sari

    2014-01-01

    This study focuses on the development of narrative structure and the relationship between narrative productivity and event content. A total of 172 Finnish children aged between four and eight participated. Their picture-elicited narrations were analysed for productivity, syntactic complexity, referential cohesion and event content. Each measure…

  1. Single-event multilevel acute total correction of complex equinocavovarus deformity in skeletally mature patients with spastic cerebral palsy hemiparesis.

    PubMed

    Bishay, Sherif N G

    2013-01-01

    Complex multiplanar ankle/foot deformity as equinocavovarus is a common problem in patients with spastic cerebral palsy hemiparesis. The data from 30 consecutive patients (30 feet), treated between March 2009 and March 2010, with equinocavovarus and toe clawing secondary to spastic cerebral palsy hemiparesis, aged 16 to 18 years, were analyzed clinically and radiographically. All the patients had received conservative physiotherapy treatment and ankle/foot orthoses before undergoing combined soft tissue and bony surgical procedures performed in a single session to correct the complex toe clawing, cavus, varus, and equinus deformities. Preoperative measurements of certain foot angles were compared with their corresponding postoperative values. A grading system for evaluation of the results using a point scoring system was used to accurately evaluate both the clinical and the radiographic results after an average follow-up period of 2.5 years. Of the 30 patients (30 feet), 18 (60%) had excellent, 9 (30%) good, 3 (10%) fair, and 0 had poor outcomes. Neither vascular problems nor nonunion occurred. Significant improvement was seen postoperatively (p < .0333). Neither staged surgical procedures nor gradual distraction techniques using external fixators are ideal modalities to correct complex ankle/foot equinocavovarus deformity in patients with spastic cerebral palsy. Single-event, multilevel surgery with complete soft tissue and bony correction appears to be the treatment of choice in such cases. It shortens the treatment period and avoids patient dissatisfaction associated with multiple procedures, without major complications.

  2. Complexity of Arsenic Biogeochemistry in Surface Water Systems as Influenced by a Hydrologic Event

    NASA Astrophysics Data System (ADS)

    Markley, C. T.; Herbert, B. E.

    2006-12-01

    The arsenic cycle in oxic, surface water environments is often controlled by oxy-hydroxide minerals through sorption/desorption and precipitation/dissolution reactions. However, there are numerous instances where these minerals are found in low concentrations and/or are minimally reactive with respect to aqueous arsenic species. The presence of other anions may competitively inhibit arsenic sorption to oxy-hydroxide surfaces, thus increasing the bioavailability of arsenic and the potential toxic impacts. Microbe-mediated reactions can further impact arsenic fate and transport through accumulation and biotransformation. Arsenic biotransformation via reduction and/or methylation may result in an increased proportion of thermodynamically unfavorable arsenic species such as arsenite and methylated arsenicals in oxic surface waters. The reduced arsenic species, arsenite, is considered more mobile and toxic than the oxic species, arsenate while methylated arsenicals are often considered less toxic species. The complexity of these biogeochemical characteristics highlights the importance of studying arsenic in surface water environments. Particulate and aqueous phase metals (Fe, Mn, Al) and anions (As, P, S) were measured in surface water samples collected from the outflow creek of an arsenic-contaminated lake at high and low flow rates. Arsenic speciation, quantified via HPLC-ICP-MS, was dominated by methylated arsenicals at concentrations up to 82.7 μg/l. The common oxide-forming elements, Fe, Mn and Al were measured via ICP-AES at concentrations up to 2.4 mg/l, 0.88 mg/l and 3.3 mg/l, respectively. However, arsenic was not associated with the particulate phase mineralogy, being approximately 100% in the aqueous (< 0.2 μm ) phase, indicating high arsenic bioavailability. High alkalinity, phosphorous and sulfur concentrations up to 516 mgHCO3/meq, 2.0mg/l and 50 mg/l, respectively, likely out-competed arsenic for sorption to these oxide mineral surfaces. Geochemical

  3. Carotenoid-to-chlorophyll energy transfer in recombinant major light-harvesting complex (LHCII) of higher plants. I. Femtosecond transient absorption measurements.

    PubMed Central

    Croce, R; Müller, M G; Bassi, R; Holzwarth, A R

    2001-01-01

    The energy transfer kinetics from carotenoids to chlorophylls and among chlorophylls has been measured by femtosecond transient absorption kinetics in a monomeric unit of the major light-harvesting complex (LHCII) from higher plants. The samples were reconstituted complexes with different carotenoid contents. The kinetics was measured both in the carotenoid absorption region and in the chlorophyll Q(y) region using two different excitation wavelengths suitable for selective excitation of the carotenoids. Analysis of the data shows that the overwhelming part of the energy transfer from the carotenoids occurs directly from the initially excited S(2) state of the carotenoids. Only a small part (<20%) may possibly take an S(1) pathway. All the S(2) energy transfer from carotenoids to chlorophylls occurs with time constants <100 fs. We have been able to differentiate among the three carotenoids, two luteins and neoxanthin, which have transfer times of approximately 50 and 75 fs for the two luteins, and approximately 90 fs for neoxanthin. About 50% of the energy absorbed by carotenoids is initially transferred directly to chlorophyll b (Chl b), while the rest is transferred to Chl a. Neoxanthin almost exclusively transfers to Chl b. Due to various complex effects discussed in the paper, such as a specific coupling of Chl b and Chl a excited states, the percentage of direct Chl b transfer thus is somewhat lower than estimated by us previously for LHCII from Arabidopsis thaliana. (Connelly, J. P., M. G. Müller, R. Bassi, R. Croce, and A. R. Holzwarth. 1997. Biochemistry. 36:281). We can distinguish three different Chls b receiving energy directly from carotenoids. We propose as a new mechanism that the carotenoid-to-Chl b transfer occurs to a large part via the B(x) state of Chl b and to the Q(x) state, while the transfer to Chl a occurs only via the Q(x) state. We find no compelling evidence in favor of a substantial S(1) transfer path of the carotenoids, although some

  4. The Scanning Mass Spectrometry Probe: A Scanning Probe Electrospray Ion Source for Imaging Mass Spectrometry of Submerged Interfaces and Transient Events in Solution

    PubMed Central

    Kottke, Peter A.; Degertekin, F. Levent; Fedorov, Andrei G.

    2009-01-01

    The scanning mass spectrometry (SMS) probe is new electrospray ion source. Motivated by the need for untargeted chemical imaging of dynamic events in solution, we have exploited an approach to electrospray ionization (ESI) that allows continuous sampling from a highly localized volume (~picoliters) in a liquid environment, softly ionizes molecules in the sample to render them amenable for mass spectrometric analysis, and sends the ions to the mass spectrometer. The key underlying concepts for our approach are1)Treating the electrospray capillary inlet as a chemical scanning probe, and2)Locating the electrospray point as close as possible to the sampling point, thus providing the shortest response time possible. This approach enables chemical monitoring or imaging of submerged interfaces, providing access to details of spatial heterogeneity and temporal changes within liquid samples. It also permits direct access to liquid/ liquid interfaces for ESI-MS analysis. In this Letter we report the first demonstrations of these capabilities of the SMS probe, and describe some of the probe's basic characteristics. PMID:19904914

  5. Detecting aseismic transients using seismicity

    NASA Astrophysics Data System (ADS)

    Reverso, T.; Marsan, D.; Helmstetter, A.

    2013-12-01

    Aseismic deformation transients occur in different tectonic context. In subduction zones, aseismic slip events are of paramount importance for understanding earthquake hazard, and for estimating the potential for future mega-thrust events. Aseismic slip is however difficult to detect except for the largest cases using GPS data. Here, we propose a systematic detection of aseismic deformation transients based on seismicity data alone. We search for transient increases in background seismicity rate, that would indicate the presence of an aseismic event. To that purpose, we make use of an ETAS model in space and time, to distinguish earthquakes due to background processes from aftershocks. We optimize the model parameters, and test the sensitivity of the results with changes in parameters. Given the 'best' model, we measure the statistical significance of the departure of the local (in time and space) background rate with the 'normal' background rate. Significant departure then indicates the need to temporary increase the background rate in order to explain the observed earthquake occurrences. We thus can single out such episodes of aseismic transients, and characterize their duration and spatial extent. Applying this method to the Aleutian subduction zone reveals several instances of aseismic deformation transients, at various spatial and temporal scales. We further investigate how these transients are organized along the subduction interface, and in time.

  6. Peach Bottom Transients Analysis with TRAC/BF1-VALKIN

    SciTech Connect

    Verdu, G.; Miro, R.; Sanchez, A.M.; Rosello, O.; Ginestar, D.; Vidal, V.

    2004-10-15

    The TRAC/BF1-VALKIN code is a new time domain analysis code for studying transients in a boiling water reactor. This code uses the best-estimate code TRAC/BF1 to give an account of the heat transfer and thermal-hydraulic processes and a three-dimensional neutronics module. This module has two options: the MODKIN option that makes use of a modal method based on the assumption that the neutronic flux can be approximately expanded in terms of the dominant lambda modes associated with a static configuration of the reactor core, and the NOKIN option that uses a one-step backward discretization of the neutron diffusion equation. To check the performance of the TRAC/BF1-VALKIN code, the Peach Bottom turbine trip transient has been simulated, because this transient is a dynamically complex event where neutron kinetics is coupled with thermal hydraulics in the reactor primary system, and reactor variables change very rapidly.

  7. Coherence in metal-metal-to-ligand-charge-transfer excited states of a dimetallic complex investigated by ultrafast transient absorption anisotropy.

    PubMed

    Cho, Sung; Mara, Michael W; Wang, Xianghuai; Lockard, Jenny V; Rachford, Aaron A; Castellano, Felix N; Chen, Lin X

    2011-04-28

    Coherence in the metal-metal-to-ligand-charge transfer (MMLCT) excited state of diplatinum molecule [Pt(ppy)(μ-(t)Bu(2)pz)](2) has been investigated through the observed oscillatory features and their corresponding frequencies as well as polarization dependence in the single-wavelength transient absorption (TA) anisotropy signals. Anticorrelated parallel and perpendicular TA signals with respect to the excitation polarization direction were captured, while minimal oscillatory features were observed in the magic angle TA signal. The combined analysis of the experimental results coupled with those previous calculated in the literature maps out a plausible excited state trajectory on the potential energy surface, suggesting that (1) the two energetically close MMLCT excited states due to the symmetry of the molecule may be electronically and coherently coupled with the charge density shifting back and forth between the two phenylpyridine (ppy) ligands, (2) the electronic coupling strength in the (1)MMLCT and (3)MMLCT states may be extracted from the oscillation frequencies of the TA signals to be 160 and 55 cm(-1), respectively, (3) a stepwise intersystem crossing cascades follows (1)MMLCT → (3)MMLCT (T(1b)) → (3)MMLCT (T(1a)), and (4) a possible electronic coherence can be modulated via the Pt-Pt σ-interactions over a picosecond and survive the first step of intersystem crossing. Future experiments are in progress to further investigate the origin of the oscillatory features. These experimental observations may have general implications in design of multimetal center complexes for photoactivated reactions where coherence in the excited states may facilitate directional charge or energy transfer along a certain direction between different parts of a molecule.

  8. ON DETECTING TRANSIENT PHENOMENA

    SciTech Connect

    Belanger, G.

    2013-08-10

    Transient phenomena are interesting and potentially highly revealing of details about the processes under observation and study that could otherwise go unnoticed. It is therefore important to maximize the sensitivity of the method used to identify such events. In this article, we present a general procedure based on the use of the likelihood function for identifying transients which is particularly suited for real-time applications because it requires no grouping or pre-processing of the data. The method makes use of all the information that is available in the data throughout the statistical decision-making process, and is suitable for a wide range of applications. Here we consider those most common in astrophysics, which involve searching for transient sources, events or features in images, time series, energy spectra, and power spectra, and demonstrate the use of the method in the case of a weak X-ray flare in a time series and a short-lived quasi-periodic oscillation in a power spectrum. We derive a fit statistic that is ideal for fitting arbitrarily shaped models to a power density distribution, which is of general interest in all applications involving periodogram analysis.

  9. Evolutionary site-number changes of ribosomal DNA loci during speciation: complex scenarios of ancestral and more recent polyploid events

    PubMed Central

    Rosato, Marcela; Moreno-Saiz, Juan C.; Galián, José A.; Rosselló, Josep A.

    2015-01-01

    Several genome duplications have been identified in the evolution of seed plants, providing unique systems for studying karyological processes promoting diversification and speciation. Knowledge about the number of ribosomal DNA (rDNA) loci, together with their chromosomal distribution and structure, provides clues about organismal and molecular evolution at various phylogenetic levels. In this work, we aim to elucidate the evolutionary dynamics of karyological and rDNA site-number variation in all known taxa of subtribe Vellinae, showing a complex scenario of ancestral and more recent polyploid events. Specifically, we aim to infer the ancestral chromosome numbers and patterns of chromosome number variation, assess patterns of variation of both 45S and 5S rDNA families, trends in site-number change of rDNA loci within homoploid and polyploid series, and reconstruct the evolutionary history of rDNA site number using a phylogenetic hypothesis as a framework. The best-fitting model of chromosome number evolution with a high likelihood score suggests that the Vellinae core showing x = 17 chromosomes arose by duplication events from a recent x = 8 ancestor. Our survey suggests more complex patterns of polyploid evolution than previously noted for Vellinae. High polyploidization events (6x, 8x) arose independently in the basal clade Vella castrilensis–V. lucentina, where extant diploid species are unknown. Reconstruction of ancestral rDNA states in Vellinae supports the inference that the ancestral number of loci in the subtribe was two for each multigene family, suggesting that an overall tendency towards a net loss of 5S rDNA loci occurred during the splitting of Vellinae ancestors from the remaining Brassiceae lineages. A contrasting pattern for rDNA site change in both paleopolyploid and neopolyploid species was linked to diversification of Vellinae lineages. This suggests dynamic and independent changes in rDNA site number during speciation processes and a

  10. Assessing the Influence of an Individual Event in Complex Fault Spreading Network Based on Dynamic Uncertain Causality Graph.

    PubMed

    Dong, Chunling; Zhao, Yue; Zhang, Qin

    2016-08-01

    Identifying the pivotal causes and highly influential spreaders in fault propagation processes is crucial for improving the maintenance decision making for complex systems under abnormal and emergency situations. A dynamic uncertain causality graph-based method is introduced in this paper to explicitly model the uncertain causalities among system components, identify fault conditions, locate the fault origins, and predict the spreading tendency by means of probabilistic reasoning. A new algorithm is proposed to assess the impacts of an individual event by investigating the corresponding node's time-variant betweenness centrality and the strength of global causal influence in the fault propagation network. The algorithm does not depend on the whole original and static network but on the real-time spreading behaviors and dynamics, which makes the algorithm to be specifically targeted and more efficient. Experiments on both simulated networks and real-world systems demonstrate the accuracy, effectiveness, and comprehensibility of the proposed method for the fault management of power grids and other complex networked systems.

  11. Initiation of a coronal transient

    SciTech Connect

    Low, B.C.; Munro, R.H.; Fisher, R.R.

    1982-03-01

    This paper analyzes the coronal transient/eruptive prominence event of 1980 August 5 observed by the Mauna Loa experiment system. This event yielded data on the early development of the transient in the low corona between 1.2 R/sub sun/ and 2.2 R/sub sun/, information which was not available when earlier attempts were made to explain transient phenomena. The transient's initial appearance in the form of a rising density-depleted structure, prior to the eruption of the associated prominence, can be explained as an effect of magnetic buoyancy. The data indicate that this transient has a density depletion of 17% to 33% relative to an undisturbed corona which is approximately isothermal with a temperature of 1.5 x 10/sup 6/ K and a coronal density of 1.0 x 10/sup 9/ cm/sup -3/ at the base of the corona. The height versus base length relationship of the evolving transient resembles, remarkably well, the theoretical predictions obtained from a quasi-static model of a margnetically buoyant loop system. By matching this relationship with the theoretical model, we estimate the magnetic field at the base of the transient to be between 2 and 3 gauss. It is also shown that the initial, nearly constant speed of the top of the transient, 80 +- 20 km s/sup -1/, is consistent with a theoretical estimate calculated from the quasi-static model. These results suggest that some transients are not initiated impulsively, the initial stage of the development being driven by a quasi-static response to a slow change in magnetic field conditions at the base of the corona.

  12. Searching for Low-Frequency Radio Transients from Supernovae

    NASA Astrophysics Data System (ADS)

    Tsai-Wei, Jr.; Cutchin, Sean; Kothari, Manthan; Schmitt, Christian; Kavic, Michael; Simonetti, John

    2011-10-01

    Supernovae events may be accompanied by prompt emission of a low-frequency electromagnetic transient. These transient events are created by the interaction of a shock wave of charged particles created by SN core-collapse with a stars ambient magnetic field. Such events can be detected in low-frequency radio array. Here we discuss an ongoing search for such events using two radio arrays: the Long Wavelength Array (LWA) and Eight-meter-wavelength Transient Array (ETA).

  13. The effects of synoptical weather pattern and complex terrain on the formation of aerosol events in the Greater Taipei area.

    PubMed

    Chuang, Ming-Tung; Chiang, Pen-Chi; Chan, Chang-Chuan; Wang, Chu-Fang; Chang, E-E; Lee, Chung-Te

    2008-07-25

    The aerosol in the Taipei basin is difficult to transport outward under specific weather patterns owing to complex terrain blocking. In this study, seven weather patterns are identified from synoptic weather maps for aerosol events, which occurred from March 2002 to February 2005. Among the identified weather patterns, High Pressure Peripheral Circulation (HPPC), Warm area Ahead of a cold Front (WAF), TYPhoon (TYP), Pacific High Pressure system stretching westerly (PHP), Weak High Pressure system (WHP), and Weak Southern Wind (WSW) are related to terrain blocking. The remaining pattern is High Pressure system Pushing (HPP). The classification of the pollution origin of the air masses shows that 15% of event days were contributed by long-range transport (LRT), 20% by local pollution (LP), and 65% by LRT/LP mix. Terrain blocking causes aerosol accumulation from high atmospheric stability and weak winds occurring under HPPC, TYP, and PHP weather patterns when the Taipei basin is situated on the lee side of the Snow Mountains Chain (SMC). Terrain blocking also occurs when the Taipei basin is situated on the upwind of SMC and Mt. Da-Twen under WAF and WSW patterns. To study the variation of aerosol properties under the mixed influence of terrain and pollution origin, we conducted a field observation simultaneously at the urban, suburban, and background sites in the Greater Taipei area from April 14 to 23, 2004. Terrain blocking plays an important role in aerosol accumulation in the stagnant environment when the Taipei basin is on the lee side of SMC. On the other hand, the PM(2.5) sulfate level is stable with a fraction of 30% in PM(2.5) during the observation period at the urban (25%-33%) and background (25%-41%) sites. It indicates that background PM(2.5) sulfate is high on the West Pacific in winter.

  14. Studies of Transient Meteor Activity

    NASA Technical Reports Server (NTRS)

    Jenniskens, Peter M. M.

    2002-01-01

    Meteoroids bombard Earth's atmosphere daily, but occasionally meteor rates increase to unusual high levels when Earth crosses the relatively fresh ejecta of comets. These transient events in meteor activity provide clues about the whereabouts of Earth-threatening long-period comets, the mechanisms of large-grain dust ejection from comets, and the particle composition and size distribution of the cometary ejecta. Observations of these transient events provide important insight in natural processes that determine the large grain dust environment of comets, in natural phenomena that were prevalent during the time of the origin of life, and in processes that determine the hazard of civilizations to large impacts and of man-made satellites to the periodic blizzard of small meteoroids. In this proposal, three tasks form a coherent program aimed at elucidating various aspects of meteor outbursts, with special reference to planetary astronomy and astrobiology. Task 1 was a ground-based effort to observe periods of transient meteor activity. This includes: (1) stereoscopic imaging of meteors during transient meteor events for measurements of particle size distribution, meteoroid orbital dispersions and fluxes; and (2) technical support for Global-MS-Net, a network of amateur-operated automatic counting stations for meteor reflections from commercial VHF radio and TV broadcasting stations, keeping a 24h vigil on the level of meteor activity for the detection of new meteor streams. Task 2 consisted of ground-based and satellite born spectroscopic observations of meteors and meteor trains during transient meteor events for measurements of elemental composition, the presence of organic matter in the meteoroids, and products generated by the interaction of the meteoroid with the atmosphere. Task 3 was an airborne effort to explore the 2000 Leonid meteor outbursts, which are anticipated to be the most significant of transient meteor activity events in the remainder of the

  15. Ultrafast transient absorption studies of environment influence on the photolysis of B12 complexes and the subsequent recombination and escape of caged radicals

    NASA Astrophysics Data System (ADS)

    Stickrath, Andrew B.

    Femtosecond to nanosecond transient absorption experiments were performed on a series of B12 complexes to assess the influence of the solvent environment on the excited state electronic structure and resulting dynamics. A series of alkylcobalamins (adenosyl-, ethyl, methyl, and propylcobalamin), all of which are known to undergo cobalt-carbon bond homolysis in response to excitation at 400nm were studied in a variety of surroundings. Measurements on adenosylcobalamin (coenzyme B12) bound to glutamate mutase demonstrate a metal-to-ligand-charge-transfer (MLCT) state en route to bond homolysis, supported by protein influence on the excited state electronic structure. This charge transfer intermediate, which is similar to that reported in the literature for methylcobalamin, is not observed for free adenosylcobalamin. Measurements on methylcobalamin probe solvent influence on the MLCT state and characterize it by a large charge density transfer. This result is in contrast to studies on cyanocobalamin, which is not observed to undergo homolysis, where the solvent dependent lifetime of an intermediate ligand-to-metal-charge-transfer (LMCT) state is characterized by a modest transfer of charge density. Such a LMCT intermediate is observed for adenosylcobalamin in water leading to bond homolysis. The protein has greatly altered the photochemical pathway to homolysis, which is expected to be representative of influence on thermolysis. Upon homolysis the photoinduced alkyl and cob(II)alamin radicals may recombine or escape the solvent cage to form solvent separated radical pairs which do not recombine in the bulk by the 9ns time limit of these experiments. Recombination can be monitored directly via the oxidation state of the cobalt atom. The neutral alkyl radical is a paradigm for small particle escape and diffusive motion in a liquid. The escape behavior is similar for adenosyl, ethyl, and propyl radicals indicating that hydrogen bonding with the solvent is not a major

  16. (Nitro)Iron(III) Porphyrins. EPR Detection of a Transient Low-Spin Iron(III) Complex and Structural Characterization of an O Atom Transfer Product.

    PubMed

    Munro, Orde Q.; Scheidt, W. Robert

    1998-05-04

    The reaction of BF(3).OEt(2) with the bis(nitro) complex of iron(III) picket-fence porphyrin, [K(18C6)(OH(2))][Fe(TpivPP)(NO(2))(2)], leads to the formation of a transient porphyrin intermediate, assigned on the basis of its rhombic low-spin EPR spectrum as the five-coordinate N-bound mono(nitro) iron(III) derivative, [Fe(TpivPP)(NO(2))]. This species is reactive and readily undergoes oxygen atom transfer to form [Fe(III)(TpivPP)(NO(3))] and [Fe(II)(TpivPP)(NO)]. The reactions have been followed by EPR and IR spectroscopy. [Fe(TpivPP)(NO(2))] has a rhombic EPR spectrum (g = 2.60, 2.35, and 1.75) in chlorobenzene and CH(2)Cl(2) and is spectroscopically distinct from the bis(nitro) starting material (g = 2.70, 2.50, and 1.57). Oxidation of the nitrosyl species to [Fe(TpivPP)(NO(3))] proceeds via an intermediate assigned as [Fe(TpivPP)(NO(2))] on the basis of its EPR spectrum. The crystal structure of one of the reaction products, [Fe(TpivPP)(NO(3))], has been determined. The nitrate ion of [Fe(TpivPP)(NO(3))] is bound to the iron(III) ion in a "symmetric" bidentate fashion within the ligand-binding pocket of the porphyrin pickets. Individual Fe-O distances are 2.123(3) and 2.226(3) Å. The dihedral angle between the plane of the nitrate ion and the closest N(p)-Fe-N(p) plane is 10.0 degrees. The Fe-N(p) bonds (and trans N(p)-Fe-N(p) angles) perpendicular and parallel to the plane of the axial ligand average to 2.060(5) Å (154.84(9) degrees ) and 2.083(3) Å (146.14(9) degrees ), respectively. Crystal data for [Fe(TpivPP)(NO(3))]: a = 23.530(2) Å, b = 10.0822(5) Å, c = 48.748(3) Å, beta = 92.145(5) degrees, monoclinic, space group I2/a, V = 11556.4(14) Å(3), Z = 8, FeN(9)O(7)C(64)H(64), 8798 observed data, R(1) = 0.0606, wR(2) = 0.1313, all observations at 127(2) K.

  17. A Multiple-Channel Sub-Band Transient Detection System

    SciTech Connect

    David A. Smith

    1998-11-01

    We have developed a unique multiple-channel sub-band transient detection system to record transient electromagnetic signals in carrier-dominated radio environments; the system has been used to make unique observations of weak, transient HF signals. The detection system has made these observations possible through improved sensitivity compared to conventional broadband transient detection systems; the sensitivity improvement is estimated to be at least 20 dB. The increase in sensitivity has been achieved through subdivision of the band of interest (an 18 MHz tunable bandwidth) into eight sub-band independent detection channels, each with a 400 kHz bandwidth and its own criteria. The system generates a system trigger signal when a predetermined number of channels (typically five) trigger within a predetermined window of time (typically 100 ~s). Events are recorded with a broadband data acquisition system sampling at 50 or 100 Msample/s, so despite the fact that the detection system operates on portions of the signal confined to narrow bands, data acquisition is broadband. Between May and September of 1994, the system was used to detect and record over six thousand transient events in the frequency band from 3 to 30 MHz. Approximately 500 of the events have been characterized as paired bursts of radio noise with individual durations of 2 to 10 ps and separations between the bursts of 5 to 160 ps. The paired transients are typically 5 to 40 dB brighter than the background electromagnetic spectrum between carrier signals. We have termed these events SubIonospheric Pulse Pairs (SIPPS) and presently have no explanation as to their source. Our observations of SIPPS resemble observations of TransIonospheric Pulse Pairs (TIPPs) recorded by the Blackboard instrument on the ALEXIS satellite; the source of TIPP events is also unknown. Most of the recorded SIPP events do not exhibit frequency dispersion, implying propagation along a line-of-sight (groundwave) path; but seven of

  18. Using Complex Event Processing (CEP) and vocal synthesis techniques to improve comprehension of sonified human-centric data

    NASA Astrophysics Data System (ADS)

    Rimland, Jeff; Ballora, Mark

    2014-05-01

    The field of sonification, which uses auditory presentation of data to replace or augment visualization techniques, is gaining popularity and acceptance for analysis of "big data" and for assisting analysts who are unable to utilize traditional visual approaches due to either: 1) visual overload caused by existing displays; 2) concurrent need to perform critical visually intensive tasks (e.g. operating a vehicle or performing a medical procedure); or 3) visual impairment due to either temporary environmental factors (e.g. dense smoke) or biological causes. Sonification tools typically map data values to sound attributes such as pitch, volume, and localization to enable them to be interpreted via human listening. In more complex problems, the challenge is in creating multi-dimensional sonifications that are both compelling and listenable, and that have enough discrete features that can be modulated in ways that allow meaningful discrimination by a listener. We propose a solution to this problem that incorporates Complex Event Processing (CEP) with speech synthesis. Some of the more promising sonifications to date use speech synthesis, which is an "instrument" that is amenable to extended listening, and can also provide a great deal of subtle nuance. These vocal nuances, which can represent a nearly limitless number of expressive meanings (via a combination of pitch, inflection, volume, and other acoustic factors), are the basis of our daily communications, and thus have the potential to engage the innate human understanding of these sounds. Additionally, recent advances in CEP have facilitated the extraction of multi-level hierarchies of information, which is necessary to bridge the gap between raw data and this type of vocal synthesis. We therefore propose that CEP-enabled sonifications based on the sound of human utterances could be considered the next logical step in human-centric "big data" compression and transmission.

  19. Fungal Iron Availability during Deep Seated Candidiasis Is Defined by a Complex Interplay Involving Systemic and Local Events

    PubMed Central

    Potrykus, Joanna; Stead, David; MacCallum, Donna M.; Urgast, Dagmar S.; Raab, Andrea; van Rooijen, Nico; Feldmann, Jörg; Brown, Alistair J. P.

    2013-01-01

    Nutritional immunity – the withholding of nutrients by the host – has long been recognised as an important factor that shapes bacterial-host interactions. However, the dynamics of nutrient availability within local host niches during fungal infection are poorly defined. We have combined laser ablation-inductively coupled plasma mass spectrometry (LA-ICP MS), MALDI imaging and immunohistochemistry with microtranscriptomics to examine iron homeostasis in the host and pathogen in the murine model of systemic candidiasis. Dramatic changes in the renal iron landscape occur during disease progression. The infection perturbs global iron homeostasis in the host leading to iron accumulation in the renal medulla. Paradoxically, this is accompanied by nutritional immunity in the renal cortex as iron exclusion zones emerge locally around fungal lesions. These exclusion zones correlate with immune infiltrates and haem oxygenase 1-expressing host cells. This local nutritional immunity decreases iron availability, leading to a switch in iron acquisition mechanisms within mature fungal lesions, as revealed by laser capture microdissection and qRT-PCR analyses. Therefore, a complex interplay of systemic and local events influences iron homeostasis and pathogen-host dynamics during disease progression. PMID:24146619

  20. Offside decisions by expert assistant referees in association football: Perception and recall of spatial positions in complex dynamic events.

    PubMed

    Gilis, Bart; Helsen, Werner; Catteeuw, Peter; Wagemans, Johan

    2008-03-01

    This study investigated the offside decision-making process in association football. The first aim was to capture the specific offside decision-making skills in complex dynamic events. Second, we analyzed the type of errors to investigate the factors leading to incorrect decisions. Fédération Internationale de Football Association (FIFA; n = 29) and Belgian elite (n = 28) assistant referees (ARs) assessed 64 computer-based offside situations. First, an expertise effect was found. The FIFA ARs assessed the trials more accurately than the Belgian ARs (76.4% vs. 67.5%). Second, regarding the type of error, all ARs clearly tended to raise their flag in doubtful situations. This observation could be explained by a perceptual bias associated with the flash-lag effect. Specifically, attackers were perceived ahead of their actual positions, and this tendency was stronger for the Belgian than for the FIFA ARs (11.0 vs. 8.4 pixels), in particular when the difficulty of the trials increased. Further experimentation is needed to examine whether video- and computer-based decision-making training is effective in improving the decision-making skills of ARs during the game.