Science.gov

Sample records for complexity tier development

  1. Professional Development to Differentiate Kindergarten Tier 1 Instruction: Can Already Effective Teachers Improve Student Outcomes by Differentiating Tier 1 Instruction?

    ERIC Educational Resources Information Center

    Al Otaiba, Stephanie; Folsom, Jessica S.; Wanzek, Jeanne; Greulich, Luana; Waesche, Jessica; Schatschneider, Christopher; Connor, Carol M.

    2016-01-01

    Two primary purposes guided this quasi-experimental within-teacher study: (a) to examine changes from baseline through 2 years of professional development (Individualizing Student Instruction) in kindergarten teachers' differentiation of Tier 1 literacy instruction; and (b) to examine changes in reading and vocabulary of 3 cohorts of the teachers'…

  2. An Application Model of Reality Therapy to Develop Effective Achievement Goals in Tier Three Intervention

    ERIC Educational Resources Information Center

    Sunawan; Xiong, Junmei

    2016-01-01

    This article describes an application of reality therapy to developing effective achievement goals for students in tier three of a tiered response to intervention approach. The roles of teachers and school counselors, to improve effective achievement goals, are briefly discussed as a frame for applying reality therapy. The application model…

  3. The Development and Validation of a Three-Tier Diagnostic Test Measuring Pre-Service Elementary Education and Secondary Science Teachers' Understanding of the Water Cycle

    ERIC Educational Resources Information Center

    Schaffer, Dannah Lynn

    2013-01-01

    The main goal of this research study was to develop and validate a three-tier diagnostic test to determine pre-service teachers' (PSTs) conceptual knowledge of the water cycle. For a three-tier diagnostic test, the first tier assesses content knowledge; in the second tier, a reason is selected for the content answer; and the third tier allows…

  4. The JINR Tier1 Site Simulation for Research and Development Purposes

    NASA Astrophysics Data System (ADS)

    Korenkov, V.; Nechaevskiy, A.; Ososkov, G.; Pryahina, D.; Trofimov, V.; Uzhinskiy, A.; Voytishin, N.

    2016-02-01

    Distributed complex computing systems for data storage and processing are in common use in the majority of modern scientific centers. The design of such systems is usually based on recommendations obtained via a preliminary simulated model used and executed only once. However big experiments last for years and decades, and the development of their computing system is going on, not only quantitatively but also qualitatively. Even with the substantial efforts invested in the design phase to understand the systems configuration, it would be hard enough to develop a system without additional research of its future evolution. The developers and operators face the problem of the system behaviour predicting after the planned modifications. A system for grid and cloud services simulation is developed at LIT (JINR, Dubna). This simulation system is focused on improving the effciency of the grid/cloud structures development by using the work quality indicators of some real system. The development of such kind of software is very important for making a new grid/cloud infrastructure for such big scientific experiments like the JINR Tier1 site for WLCG. The simulation of some processes of the Tier1 site is considered as an example of our application approach.

  5. Development of three-tier heat, temperature and internal energy diagnostic test

    NASA Astrophysics Data System (ADS)

    Gurcay, Deniz; Gulbas, Etna

    2015-05-01

    Background:Misconceptions are major obstacles to learning physics, and the concepts of heat and temperature are some of the common misconceptions that are encountered in daily life. Therefore, it is important to develop valid and reliable tools to determine students' misconceptions about basic thermodynamics concepts. Three-tier tests are effective assessment tools to determine misconceptions in physics. Although a limited number of three-tier tests about heat and temperature are discussed in the literature, no reports discuss three-tier tests that simultaneously consider heat, temperature and internal energy. Purpose:The aim of this study is to develop a valid and reliable three-tier test to determine students' misconceptions about heat, temperature and internal energy. Sample:The sample consists of 462 11th-grade Anatolian high school students. Of the participants, 46.8% were female and 53.2% were male. Design and methods:This research takes the form of a survey study. Initially, a multiple-choice test was developed. To each multiple-choice question was added one open-ended question asking the students to explain their answers. This test was then administered to 259 high school students and the data were analyzed both quantitatively and qualitatively. The students' answers for each open-ended question were analyzed and used to create the choices for the second-tier questions of the test. Depending on those results, a three-tier Heat, Temperature and Internal Energy Diagnostic Test (HTIEDT) was developed by adding a second-tier and certainty response index to each item. This three-tier test was administered to the sample of 462 high school students. Results:The Cronbach alpha reliability for the test was estimated for correct and misconception scores as .75 and .68, respectively. The results of the study suggested that HTIEDT could be used as a valid and reliable test in determining misconceptions about heat, temperature and internal energy concepts.

  6. Regulatory Compliance in Multi-Tier Supplier Networks

    NASA Technical Reports Server (NTRS)

    Goossen, Emray R.; Buster, Duke A.

    2014-01-01

    Over the years, avionics systems have increased in complexity to the point where 1st tier suppliers to an aircraft OEM find it financially beneficial to outsource designs of subsystems to 2nd tier and at times to 3rd tier suppliers. Combined with challenging schedule and budgetary pressures, the environment in which safety-critical systems are being developed introduces new hurdles for regulatory agencies and industry. This new environment of both complex systems and tiered development has raised concerns in the ability of the designers to ensure safety considerations are fully addressed throughout the tier levels. This has also raised questions about the sufficiency of current regulatory guidance to ensure: proper flow down of safety awareness, avionics application understanding at the lower tiers, OEM and 1st tier oversight practices, and capabilities of lower tier suppliers. Therefore, NASA established a research project to address Regulatory Compliance in a Multi-tier Supplier Network. This research was divided into three major study efforts: 1. Describe Modern Multi-tier Avionics Development 2. Identify Current Issues in Achieving Safety and Regulatory Compliance 3. Short-term/Long-term Recommendations Toward Higher Assurance Confidence This report presents our findings of the risks, weaknesses, and our recommendations. It also includes a collection of industry-identified risks, an assessment of guideline weaknesses related to multi-tier development of complex avionics systems, and a postulation of potential modifications to guidelines to close the identified risks and weaknesses.

  7. CarD stabilizes mycobacterial open complexes via a two-tiered kinetic mechanism.

    PubMed

    Rammohan, Jayan; Ruiz Manzano, Ana; Garner, Ashley L; Stallings, Christina L; Galburt, Eric A

    2015-03-31

    CarD is an essential and global transcriptional regulator in mycobacteria. While its biological role is unclear, CarD functions by interacting directly with RNA polymerase (RNAP) holoenzyme promoter complexes. Here, using a fluorescent reporter of open complex, we quantitate RPo formation in real time and show that Mycobacterium tuberculosis CarD has a dramatic effect on the energetics of RNAP bound complexes on the M. tuberculosis rrnAP3 ribosomal RNA promoter. The data reveal that Mycobacterium bovis RNAP exhibits an unstable RPo that is stabilized by CarD and suggest that CarD uses a two-tiered, concentration-dependent mechanism by associating with open and closed complexes with different affinities. Specifically, the kinetics of open-complex formation can be explained by a model where, at saturating concentrations of CarD, the rate of bubble collapse is slowed and the rate of opening is accelerated. The kinetics and open-complex stabilities of CarD mutants further clarify the roles played by the key residues W85, K90 and R25 previously shown to affect CarD-dependent gene regulation in vivo. In contrast to M. bovis RNAP, Escherichia coli RNAP efficiently forms RPo on rrnAP3, suggesting an important difference between the polymerases themselves and highlighting how transcriptional machinery can vary across bacterial genera.

  8. CarD stabilizes mycobacterial open complexes via a two-tiered kinetic mechanism

    PubMed Central

    Rammohan, Jayan; Ruiz Manzano, Ana; Garner, Ashley L.; Stallings, Christina L.; Galburt, Eric A.

    2015-01-01

    CarD is an essential and global transcriptional regulator in mycobacteria. While its biological role is unclear, CarD functions by interacting directly with RNA polymerase (RNAP) holoenzyme promoter complexes. Here, using a fluorescent reporter of open complex, we quantitate RPo formation in real time and show that Mycobacterium tuberculosis CarD has a dramatic effect on the energetics of RNAP bound complexes on the M. tuberculosis rrnAP3 ribosomal RNA promoter. The data reveal that Mycobacterium bovis RNAP exhibits an unstable RPo that is stabilized by CarD and suggest that CarD uses a two-tiered, concentration-dependent mechanism by associating with open and closed complexes with different affinities. Specifically, the kinetics of open-complex formation can be explained by a model where, at saturating concentrations of CarD, the rate of bubble collapse is slowed and the rate of opening is accelerated. The kinetics and open-complex stabilities of CarD mutants further clarify the roles played by the key residues W85, K90 and R25 previously shown to affect CarD-dependent gene regulation in vivo. In contrast to M. bovis RNAP, Escherichia coli RNAP efficiently forms RPo on rrnAP3, suggesting an important difference between the polymerases themselves and highlighting how transcriptional machinery can vary across bacterial genera. PMID:25697505

  9. Development of a Three-Tier Test to Assess Misconceptions about Simple Electric Circuits

    ERIC Educational Resources Information Center

    Pesman, Haki; Eryilmaz, Ali

    2010-01-01

    The authors aimed to propose a valid and reliable diagnostic instrument by developing a three-tier test on simple electric circuits. Based on findings from the interviews, open-ended questions, and the related literature, the test was developed and administered to 124 high school students. In addition to some qualitative techniques for…

  10. Development of Three-Tier Heat, Temperature and Internal Energy Diagnostic Test

    ERIC Educational Resources Information Center

    Gurcay, Deniz; Gulbas, Etna

    2015-01-01

    Background: Misconceptions are major obstacles to learning physics, and the concepts of heat and temperature are some of the common misconceptions that are encountered in daily life. Therefore, it is important to develop valid and reliable tools to determine students' misconceptions about basic thermodynamics concepts. Three-tier tests are…

  11. Development and Evaluation of the Diagnostic Power for a Computer-Based Two-Tier Assessment

    ERIC Educational Resources Information Center

    Lin, Jing-Wen

    2016-01-01

    This study adopted a quasi-experimental design with follow-up interview to develop a computer-based two-tier assessment (CBA) regarding the science topic of electric circuits and to evaluate the diagnostic power of the assessment. Three assessment formats (i.e., paper-and-pencil, static computer-based, and dynamic computer-based tests) using…

  12. Development and Evaluation of the Diagnostic Power for a Computer-Based Two-Tier Assessment

    NASA Astrophysics Data System (ADS)

    Lin, Jing-Wen

    2016-06-01

    This study adopted a quasi-experimental design with follow-up interview to develop a computer-based two-tier assessment (CBA) regarding the science topic of electric circuits and to evaluate the diagnostic power of the assessment. Three assessment formats (i.e., paper-and-pencil, static computer-based, and dynamic computer-based tests) using two-tier items were conducted on Grade 4 ( n = 90) and Grade 5 ( n = 86) students, respectively. One-way ANCOVA was conducted to investigate whether the different assessment formats affected these students' posttest scores on both the phenomenon and reason tiers, and confidence rating for an answer was assessed to diagnose the nature of students' responses (i.e., scientific answer, guessing, alternative conceptions, or knowledge deficiency). Follow-up interview was adopted to explore whether and how the various CBA representations influenced both graders' responses. Results showed that the CBA, in particular the dynamic representation format, allowed students who lacked prior knowledge (Grade 4) to easily understand the question stems. The various CBA representations also potentially encouraged students who already had learning experience (Grade 5) to enhance the metacognitive judgment of their responses. Therefore, CBA could reduce students' use of test-taking strategies and provide better diagnostic power for a two-tier instrument than the traditional paper-based version.

  13. Developing Integrated Taxonomies for a Tiered Information Architecture

    NASA Technical Reports Server (NTRS)

    Dutra, Jayne E.

    2006-01-01

    This viewgraph presentation reviews the concept of developing taxonomies for an information architecture. In order to assist people in accessing information required to access information and retrieval, including cross repository searching, a system of nested taxonomies is being developed. Another facet of this developmental project is collecting and documenting attributes about people, to allow for several uses: access management, i.e., who are you and what can you see?; targeted content delivery i.e., what content helps you get your work done?; w ork force planning i.e., what skill sets do you have that we can appl y to work?; and IT Services i.e., How can we provision you with the proper IT services?

  14. Two Studies of Tier II Literacy Development: Throwing Sixth Graders a Lifeline

    ERIC Educational Resources Information Center

    Graves, Anne W.; Duesbery, Luke; Pyle, Nicole B.; Brandon, Regina R.; McIntosh, Angela S.

    2011-01-01

    Two experimental studies at one urban middle school investigated the effects of the combination of Tier I and Tier II evidence-based reading instruction compared to Tier I alone on struggling sixth-grade readers (N = 109). All participants received free or reduced-price lunch, and 95% were considered English learners at some point in their school…

  15. ADVANCED DIESEL ENGINE AND AFTERTREATMENT TECHNOLOGY DEVELOPMENT FOR TIER 2 EMISSIONS

    SciTech Connect

    Aneja, R.; Bolton, B; Oladipo, A; Pavlova-MacKinnon, Z; Radwan, A

    2003-08-24

    Advanced diesel engine and aftertreatment technologies have been developed for multiple engine and vehicle platforms. Tier 2 (2007 and beyond) emissions levels have been demonstrated for a light truck vehicle over a FTP-75 test cycle on a vehicle chassis dynamometer. These low emissions levels are obtained while retaining the fuel economy advantage characteristic of diesel engines. The performance and emissions results were achieved by integrating advanced combustion strategies (CLEAN Combustion{copyright}) with prototype aftertreatment systems. CLEAN Combustion{copyright} allows partial control of exhaust species for aftertreatment integration in addition to simultaneous NOx and PM reduction. Analytical tools enabled the engine and aftertreatment sub-systems development and system integration. The experimental technology development methodology utilized a range of facilities to streamline development of the eventual solution including utilization of steady state and transient dynamometer test-beds to simulate chassis dynamometer test cycles.

  16. Developing the Capacity to Implement Tier 2 and Tier 3 Supports: How Do We Support Our Faculty and Staff in Preparing for Sustainability?

    ERIC Educational Resources Information Center

    Oakes, Wendy Peia; Lane, Kathleen Lynne; Germer, Kathryn A.

    2014-01-01

    School-site and district-level leadership teams rely on the existing knowledge base to select, implement, and evaluate evidence-based practices meeting students' multiple needs within the context of multitiered systems of support. The authors focus on the stages of implementation science as applied to Tier 2 and Tier 3 supports; the…

  17. Development of a Three-Tier Test as a Valid Diagnostic Tool for Identification of Misconceptions Related to Carbohydrates

    ERIC Educational Resources Information Center

    Milenkovic, Dusica D.; Hrin, Tamara N.; Segedinac, Mirjana D.; Horvat, Sasa

    2016-01-01

    This study describes the development and application of a three-tier test as a valid and reliable tool in diagnosing students' misconceptions regarding some basic concepts about carbohydrates. The test was administrated to students of the Pharmacy Department at the University of Bijeljina (Serb Republic). The results denoted construct and content…

  18. Four Tiers

    ERIC Educational Resources Information Center

    Moodie, Gavin

    2009-01-01

    This paper posits a classification of tertiary education institutions into four tiers: world research universities, selecting universities, recruiting universities, and vocational institutes. The distinguishing characteristic of world research universities is their research strength, the distinguishing characteristic of selecting universities is…

  19. Towards a 'Good Life' for Farm Animals: Development of a Resource Tier Framework to Achieve Positive Welfare for Laying Hens.

    PubMed

    Edgar, Joanne L; Mullan, Siobhan M; Pritchard, Joy C; McFarlane, Una J C; Main, David C J

    2013-07-05

    The concept of a 'good life' recognises the distinction that an animal's quality of life is beyond that of a 'life worth living', representing a standard of welfare substantially higher than the legal minimum (FAWC, 2009). We propose that the opportunities required for a 'good life' could be used to structure resource tiers that lead to positive welfare and are compatible with higher welfare farm assurance schemes. Published evidence and expert opinion was used to define three tiers of resource provision (Welfare +, Welfare ++ and Welfare +++) above those stipulated in UK legislation and codes of practice, which should lead to positive welfare outcomes. In this paper we describe the principles underpinning the framework and the process of developing the resource tiers for laying hens. In doing so, we summarise expert opinion on resources required to achieve a 'good life' in laying hens and discuss the philosophical and practical challenges of developing the framework. We present the results of a pilot study to establish the validity, reliability and feasibility of the draft laying hen tiers on laying hen production systems. Finally, we propose a generic welfare assessment framework for farm animals and suggest directions for implementation, alongside outcome parameters, that can help define and promote a future 'good life' for farm animals.

  20. Overview of EDSP Tier II Larval Amphibian Growth and Development Assay histopathology and statistics

    EPA Science Inventory

    These presentations are meant to provide expert pathologists and statisticians with background information on the Tier II LAGDA design. Expert pathologists at this workshop are charged with providing guidance on histopathology considerations unique to the LAGDA. Expert statisti...

  1. Developing a two-tiered instrument with confidence levels for assessing students' conceptions of Direct Current circuits

    NASA Astrophysics Data System (ADS)

    Sabah, Saed Ahmad

    The purpose of this study is to develop and validate a two-tier revised instrument (DIRECT-TTC) for measuring students understanding of Direct Current (DC) circuits and identifying their alternative conceptions. Another main purpose of this study is to investigate the relationship between students' understanding of DC circuits and their confidence in their answers. The revised instrument consists of 15 two-tier items with a confidence scale. Both the Rasch analysis and students' interviews were used in validating the instrument and obtaining evidences for the validity of inferences. Through a two-stage quantitative and qualitative validation process using both conventional statistics and Rasch modeling, the results indicate that the instrument is both valid and reliable. The results show a statistically significant association between students' answers to the first- tier questions and explanations, r = .65 (p< .01, N = 214). The second-tier questions provided substantial information about students' conceptions of DC circuits beyond that provided by the first-tier questions. This research shows that the more able students with regard to the construct of understanding DC circuits are more likely to be confident in their answers, r = +.39 (p< .01). Several Rasch calibrations and correlation analyses indicate that the more difficult items are associated with less confidence in the correct answers. On the other hand, the results show no statistically significant relationship between item difficulty and students' confidence specifically in their incorrect answers. The difficult items with high confidence on incorrect answers exhibit the stronger alternative conceptions of DC circuits. The alternative conceptions of voltage and resistance are among the very strong alternative conceptions of DC circuits. Implications for researchers and teachers as well as recommendations for future research are presented.

  2. Development and Application of a Two-Tier Diagnostic Test for High School Students' Understanding of Flowering Plant Growth and Development

    ERIC Educational Resources Information Center

    Lin, Sheau-Wen

    2004-01-01

    This study involved the development and application of a two-tier diagnostic test measuring students' understanding of flowering plant growth and development. The instrument development procedure had three general steps: defining the content boundaries of the test, collecting information on students' misconceptions, and instrument development.…

  3. A win-win solution?: A critical analysis of tiered pricing to improve access to medicines in developing countries

    PubMed Central

    2011-01-01

    Background Tiered pricing - the concept of selling drugs and vaccines in developing countries at prices systematically lower than in industrialized countries - has received widespread support from industry, policymakers, civil society, and academics as a way to improve access to medicines for the poor. We carried out case studies based on a review of international drug price developments for antiretrovirals, artemisinin combination therapies, drug-resistant tuberculosis medicines, liposomal amphotericin B (for visceral leishmaniasis), and pneumococcal vaccines. Discussion We found several critical shortcomings to tiered pricing: it is inferior to competition for achieving the lowest sustainable prices; it often involves arbitrary divisions between markets and/or countries, which can lead to very high prices for middle-income markets; and it leaves a disproportionate amount of decision-making power in the hands of sellers vis-à-vis consumers. In many developing countries, resources are often stretched so tight that affordability can only be approached by selling medicines at or near the cost of production. Policies that "de-link" the financing of R&D from the price of medicines merit further attention, since they can reward innovation while exploiting robust competition in production to generate the lowest sustainable prices. However, in special cases - such as when market volumes are very small or multi-source production capacity is lacking - tiered pricing may offer the only practical option to meet short-term needs for access to a product. In such cases, steps should be taken to ensure affordability and availability in the longer-term. Summary To ensure access to medicines for populations in need, alternate strategies should be explored that harness the power of competition, avoid arbitrary market segmentation, and/or recognize government responsibilities. Competition should generally be the default option for achieving affordability, as it has proven superior

  4. Developing a Tiered Response Model for Social-Emotional Learning through Interdisciplinary Collaboration

    ERIC Educational Resources Information Center

    Maras, Melissa A.; Thompson, Aaron M.; Lewis, Christie; Thornburg, Kathy; Hawks, Jacqueline

    2015-01-01

    A tiered response model for social-emotional learning (SEL) is needed to address the significant mental health needs of young people in this country. In collaboration with other school mental health professionals, school psychologists have a unique expertise that situates them to be systems change agents in this work. This article describes a…

  5. Development and application of a two-tier multiple choice diagnostic instrument to assess high school students' understanding of inorganic chemistry qualitative analysis

    NASA Astrophysics Data System (ADS)

    Tan, Kim Chwee Daniel; Khang Goh, Ngoh; Sai Chia, Lian; Treagust, David F.

    2002-04-01

    This article describes the development and application of a two-tier multiple choice diagnostic instrument to assess high school students' understanding of inorganic chemistry qualitative analysis. The development of the diagnostic instrument was guided by the framework outlined by Treagust. The instrument was administered to 915 Grade 10 students (15 to 17 years old) from 11 schools after they had learned the theory involved in qualitative analysis and after a series of qualitative analysis practical sessions. The Cronbach alpha reliability of the instrument was .68, the facility indices ranged from .17 to .48, and the discrimination indices ranged from .20 to .53. The study showed that the Grade 10 students had difficulty understanding the reactions involved in the identification of cations and anions, for example, double decomposition reactions, the formation and reaction of complex salts, and thermal decomposition. The findings of the study and literature on practical work were used to develop a qualitative analysis teaching package.

  6. Periglacial complexes in Utopia Planitia: rimless, tiered depressions, (clastically) sorted and unsorted polygonised terrain and an ice-rich mantle

    NASA Astrophysics Data System (ADS)

    Soare, Richard; Conway, Susan; Gallagher, Colman; Dohm, James; Clifford, Stephen M.; Williams, Jean-pierre

    2016-10-01

    We report the spatial and possible genetic-relationship at the mid-latitudes of Utopia Planitia (45-500N 115-1200E), Mars, of: (a) metre to decametre deep, rimless, tiered depressions; terrain that exhibits (b) (clastically) sorted and (c) unsorted (small-sized) polygons; and, (d) a very youthful, ice-rich mantle. We show that these individual landscape features are separated stratigraphically, this being presented to the Mars community for the first time, and suggest that the stratigraphical separation of these features could be the result of boundary conditions and formation processes that have varied much more widely than has been thought hitherto. In cold-climate and non-glacial regions such as the Yamal Peninsula of eastern Russia and the Tuktoyaktuk Coastlands of northern Canada, landscape assemblages comprised of similar features are referenced as "ice complexes" and are indicative of periglacialism on two fronts: first, the presence of "ice-rich" permafrost or permafrost comprised of "excess ice", i.e. "permafrost" whose pore space is exceeded by the "water ice" within that body of sediment; and, second, antecedently or currently active freeze-thaw cycling, minimally, to the full depth of the "ice-complex" depressions. In the Dry Valleys of the Antarctic, where the atmospheric aridity and cold-temperatures approach those of Mars, ice-vapour diffusion and adsorption cycles are cited as the means by which the near-surface, permafrost, i.e. ≤1m deep, has become ice-cemented. However, the metre to decametre depths of the "ice-complex" depressions on Earth and the morphologically-similar ones on Mars lie beyond the vertical reach of the Antarctic diffusion and adsorption cycles, both empirically and theoretically. By deduction, this points to the freeze-thaw cycling of water to depth, fostered either by exogenic or endogenic means, perhaps playing a more important role in the formation of the possible Martian "ice complexes" than might be expected were

  7. The design of a CORBA-based PACS in three-tier architecture

    NASA Astrophysics Data System (ADS)

    Li, Zhuo; Wu, Lingda; Wei, Yingmei; Xie, Hongwei

    2005-04-01

    In the past the most of the traditional PACS adopt two-tier Client/Server architecture based on DICOM network in china. However, with the developments of PACS that becomes more large-scale and distributed, the traditional PACS architecture has a lot of weaknesses. To overcome these shortcomings, this paper presents a CORBA-based PACS in three-tier architecture which consists of the application-tier, the middle-tier and the DICOM data-tier. In application-tier, the upper applications can use the service offered from the middle-tier through the application interface. In middle-tier, the characteristic service of PACS, which are extracted from the traditional PACS, are wrapped in service components plug in the ORB software bus. For the data exchange in CORBA-based implementation, the middleware uses IIOP to call service components through the ORB then to return the results to the application-tier. The CORBA object services are responsible for the object location, creation, implementation and destruction, etc. In DICOM data-tier, DICOM image modalities and DICOM databases provide DICOM data for the middle-tier through DICOM image access service. Furthermore, a design of DICOM image access service, which accesses DICOM data and shields the middle-tier from the complexities of DICOM data structure and DIMSE protocol, is presented in this paper. After referred to the CIAS (Clinical Image Access Service) specification defined by OMG, a simplified IDL interface of DICOM image access service is also described. The CORBA-based PACS architecture is an open architecture allowing for the scalability and the interconnectivity & interoperability.

  8. Development and Application of a Two-Tier Multiple-Choice Diagnostic Test for High School Students' Understanding of Cell Division and Reproduction

    ERIC Educational Resources Information Center

    Sesli, Ertugrul; Kara, Yilmaz

    2012-01-01

    This study involved the development and application of a two-tier diagnostic test for measuring students' understanding of cell division and reproduction. The instrument development procedure had three general steps: defining the content boundaries of the test, collecting information on students' misconceptions, and instrument development.…

  9. The Science behind Curriculum Development and Evaluation: Taking a Design Science Approach in the Production of a Tier 2 Mathematics Curriculum

    ERIC Educational Resources Information Center

    Doabler, Christian T.; Clarke, Ben; Fien, Hank; Baker, Scott K.; Kosty, Derek B.; Cary, Mari Strand

    2015-01-01

    The production of an effective mathematics curriculum begins with a scientific development, evaluation, and revision framework. The purpose of this study was to conduct an initial investigation of a recently developed Tier 2 mathematics curriculum designed to improve the outcomes of first grade students at risk for mathematics difficulties (MD).…

  10. Development and Validation of a Two-Tier Instrument to Examine Understanding of Internal Transport in Plants and the Human Circulatory System

    ERIC Educational Resources Information Center

    Wang, Jing-Ru

    2004-01-01

    This study is intended to develop an assessment instrument to investigate students' understandings about internal transport in plants and human circulatory system. A refined process of a two-tier diagnostic test was used to develop the instrument. Finally, three versions of the Internal Transport in Plants and the Human Circulatory System test…

  11. The development and validation of a two-tiered multiple-choice instrument to identify alternative conceptions in earth science

    NASA Astrophysics Data System (ADS)

    Mangione, Katherine Anna

    slight positive correlation between overall score and both confidence and understanding. Responses on the questionnaire were investigated with respect to pedagogical choices. Evidence suggests that content knowledge and having alternative conceptions or science fragments may impact a teacher's pedagogical choices. Through careful development of instruments like ACES-Q II-R and other two- tiered, multiple-choice instruments, educators and researchers car not only identify possible alternative conceptions, they can raise an awareness of alternative conceptions held by children and adults.

  12. Self-Regulated Strategy Development at Tier 2 for Second-Grade Students with Writing and Behavioral Difficulties: A Randomized Controlled Trial

    ERIC Educational Resources Information Center

    Lane, Kathleen Lynne; Harris, Karen; Graham, Steve; Driscoll, Steven; Sandmel, Karin; Morphy, Paul; Hebert, Michael; House, Emily; Schatschneider, Christopher

    2011-01-01

    We examined the extent to which strategies instruction, using the Self-Regulated Strategy Development (SRSD) model, would enhance the writing, engagement during writing, and behavior of 44 second-grade students identified as having behavioral and writing difficulties. This study occurred within a comprehensive, integrated, three-tiered model of…

  13. Development and Application of a Two-Tier Multiple Choice Diagnostic Instrument To Assess High School Students' Understanding of Inorganic Chemistry Qualitative Analysis.

    ERIC Educational Resources Information Center

    Tan, Kim Chwee Daniel; Goh, Ngoh Khang; Chia, Lian Sai; Treagust, David F.

    2002-01-01

    Describes the development and application of a two-tier multiple choice diagnostic instrument to assess high school students' understanding of inorganic chemistry qualitative analysis. Shows that the Grade 10 students had difficulty understanding the reactions involved in the identification of cations and anions, for example, double decomposition…

  14. Tier identification (TID) for tiered memory characteristics

    DOEpatents

    Chang, Jichuan; Lim, Kevin T; Ranganathan, Parthasarathy

    2014-03-25

    A tier identification (TID) is to indicate a characteristic of a memory region associated with a virtual address in a tiered memory system. A thread may be serviced according to a first path based on the TID indicating a first characteristic. The thread may be serviced according to a second path based on the TID indicating a second characteristic.

  15. Development of a tiered and binned genetic counseling model for informed consent in the era of multiplex testing for cancer susceptibility

    PubMed Central

    Bradbury, Angela R.; Patrick-Miller, Linda; Long, Jessica; Powers, Jacquelyn; Stopfer, Jill; Forman, Andrea; Rybak, Christina; Mattie, Kristin; Brandt, Amanda; Chambers, Rachelle; Chung, Wendy K.; Churpek, Jane; Daly, Mary B.; Digiovanni, Laura; Farengo-Clark, Dana; Fetzer, Dominique; Ganschow, Pamela; Grana, Generosa; Gulden, Cassandra; Hall, Michael; Kohler, Lynne; Maxwell, Kara; Merrill, Shana; Montgomery, Susan; Mueller, Rebecca; Nielsen, Sarah; Olopade, Olufunmilayo; Rainey, Kimberly; Seelaus, Christina; Nathanson, Katherine L.; Domchek, Susan M.

    2016-01-01

    Purpose Multiplex genetic testing, including both moderate- and high-penetrance genes for cancer susceptibility, is associated with greater uncertainty than traditional testing, presenting challenges to informed consent and genetic counseling. We sought to develop a new model for informed consent and genetic counseling for four ongoing studies. Methods Drawing from professional guidelines, literature, conceptual frameworks, and clinical experience, a multidisciplinary group developed a tiered-binned genetic counseling approach proposed to facilitate informed consent and improve outcomes of cancer susceptibility multiplex testing. Results In this model, tier 1 “indispensable” information is presented to all patients. More specific tier 2 information is provided to support variable informational needs among diverse patient populations. Clinically relevant information is “binned” into groups to minimize information overload, support informed decision making, and facilitate adaptive responses to testing. Seven essential elements of informed consent are provided to address the unique limitations, risks, and uncertainties of multiplex testing. Conclusion A tiered-binned model for informed consent and genetic counseling has the potential to address the challenges of multiplex testing for cancer susceptibility and to support informed decision making and adaptive responses to testing. Future prospective studies including patient-reported outcomes are needed to inform how to best incorporate multiplex testing for cancer susceptibility into clinical practice. PMID:25297947

  16. A novel approach for the development of tiered use biological criteria for rivers and streams in an ecologically diverse landscape.

    PubMed

    Bouchard, R William; Niemela, Scott; Genet, John A; Yoder, Chris O; Sandberg, John; Chirhart, Joel W; Feist, Mike; Lundeen, Benjamin; Helwig, Dan

    2016-03-01

    Water resource protection goals for aquatic life are often general and can result in under protection of some high quality water bodies and unattainable expectations for other water bodies. More refined aquatic life goals known as tiered aquatic life uses (TALUs) provide a framework to designate uses by setting protective goals for high quality water bodies and establishing attainable goals for water bodies altered by legally authorized legacy activities (e.g., channelization). Development of biological criteria or biocriteria typically requires identification of a set of least- or minimally-impacted reference sites that are used to establish a baseline from which goals are derived. Under a more refined system of stream types and aquatic life use goals, an adequate set of reference sites is needed to account for the natural variability of aquatic communities (e.g., landscape differences, thermal regime, and stream size). To develop sufficient datasets, Minnesota employed a reference condition approach in combination with an approach based on characterizing a stream's response to anthropogenic disturbance through development of a Biological Condition Gradient (BCG). These two approaches allowed for the creation of ecologically meaningful and consistent biocriteria within a more refined stream typology and solved issues related to small sample sizes and poor representation of minimally- or least-disturbed conditions for some stream types. Implementation of TALU biocriteria for Minnesota streams and rivers will result in consistent and protective goals that address fundamental differences among waters in terms of their potential for restoration. PMID:26920130

  17. A novel approach for the development of tiered use biological criteria for rivers and streams in an ecologically diverse landscape.

    PubMed

    Bouchard, R William; Niemela, Scott; Genet, John A; Yoder, Chris O; Sandberg, John; Chirhart, Joel W; Feist, Mike; Lundeen, Benjamin; Helwig, Dan

    2016-03-01

    Water resource protection goals for aquatic life are often general and can result in under protection of some high quality water bodies and unattainable expectations for other water bodies. More refined aquatic life goals known as tiered aquatic life uses (TALUs) provide a framework to designate uses by setting protective goals for high quality water bodies and establishing attainable goals for water bodies altered by legally authorized legacy activities (e.g., channelization). Development of biological criteria or biocriteria typically requires identification of a set of least- or minimally-impacted reference sites that are used to establish a baseline from which goals are derived. Under a more refined system of stream types and aquatic life use goals, an adequate set of reference sites is needed to account for the natural variability of aquatic communities (e.g., landscape differences, thermal regime, and stream size). To develop sufficient datasets, Minnesota employed a reference condition approach in combination with an approach based on characterizing a stream's response to anthropogenic disturbance through development of a Biological Condition Gradient (BCG). These two approaches allowed for the creation of ecologically meaningful and consistent biocriteria within a more refined stream typology and solved issues related to small sample sizes and poor representation of minimally- or least-disturbed conditions for some stream types. Implementation of TALU biocriteria for Minnesota streams and rivers will result in consistent and protective goals that address fundamental differences among waters in terms of their potential for restoration.

  18. The Legnaro-Padova distributed Tier-2: challenges and results

    NASA Astrophysics Data System (ADS)

    Badoer, Simone; Biasotto, Massimo; Costa, Fulvia; Crescente, Alberto; Fantinel, Sergio; Ferrari, Roberto; Gulmini, Michele; Maron, Gaetano; Michelotto, Michele; Sgaravatto, Massimo; Toniolo, Nicola

    2014-06-01

    The Legnaro-Padova Tier-2 is a computing facility serving the ALICE and CMS LHC experiments. It also supports other High Energy Physics experiments and other virtual organizations of different disciplines, which can opportunistically harness idle resources if available. The unique characteristic of this Tier-2 is its topology: the computational resources are spread in two different sites, about 15 km apart: the INFN Legnaro National Laboratories and the INFN Padova unit, connected through a 10 Gbps network link (it will be soon updated to 20 Gbps). Nevertheless these resources are seamlessly integrated and are exposed as a single computing facility. Despite this intrinsic complexity, the Legnaro-Padova Tier-2 ranks among the best Grid sites for what concerns reliability and availability. The Tier-2 comprises about 190 worker nodes, providing about 26000 HS06 in total. Such computing nodes are managed by the LSF local resource management system, and are accessible using a Grid-based interface implemented through multiple CREAM CE front-ends. dCache, xrootd and Lustre are the storage systems in use at the Tier-2: about 1.5 PB of disk space is available to users in total, through multiple access protocols. A 10 Gbps network link, planned to be doubled in the next months, connects the Tier-2 to WAN. This link is used for the LHC Open Network Environment (LHCONE) and for other general purpose traffic. In this paper we discuss about the experiences at the Legnaro-Padova Tier-2: the problems that had to be addressed, the lessons learned, the implementation choices. We also present the tools used for the daily management operations. These include DOCET, a Java-based webtool designed, implemented and maintained at the Legnaro-Padova Tier-2, and deployed also in other sites, such as the LHC Italian T1. DOCET provides an uniform interface to manage all the information about the physical resources of a computing center. It is also used as documentation repository available to

  19. The development and validation of a three-tier diagnostic test measuring pre-service elementary education and secondary science teachers' understanding of the water cycle

    NASA Astrophysics Data System (ADS)

    Schaffer, Dannah Lynn

    The main goal of this research study was to develop and validate a three-tier diagnostic test to determine pre-service teachers' (PSTs) conceptual knowledge of the water cycle. For a three-tier diagnostic test, the first tier assesses content knowledge; in the second tier, a reason is selected for the content answer; and the third tier allows test-takers to select how confident they are in their answers for the first two tiers. The second goal of this study was to diagnose any alternative conceptions PSTs might have about the water cycle. The Water Cycle Diagnostic Test (WCDT) was developed using the theoretical framework by Treagust (1986, 1988, and 1995), and in similar studies that developed diagnostic tests (e.g., Calean & Subramaniam, 2010a; Odom & Barrow, 2007; Pesman & Eryilmaz, 2010). The final instrument consisted of 15 items along with a demographic survey that examined PSTs' weather-related experiences that may or may not have affected the PSTs' understanding of the water cycle. The WCDT was administered to 77 PSTs enrolled in science methods courses during the fall of 2012. Among the 77 participants, 37 of the PSTs were enrolled in elementary education (EPST) and 40 in secondary science (SPST). Using exploratory factor analysis, five categories were factored out for the WCDT: Phase Change of Water; Condensation and Storage; Clouds; Global Climate Change; and Movement through the Water Cycle. Analysis of the PSTs' responses demonstrated acceptable reliability (alpha = 0.62) for the instrument, and acceptable difficulty indices and discrimination indices for 12 of the items. Analysis indicated that the majority of the PSTs had a limited understanding of the water cycle. Of the PSTs sampled, SPSTs were significantly more confident in their answers' on the WCDT than the EPSTs. Completion of an undergraduate atmospheric science and/or meteorology course, as well as a higher interest in listening and/or viewing weather-related programs, resulted in PSTs

  20. Towards a ‘Good Life’ for Farm Animals: Development of a Resource Tier Framework to Achieve Positive Welfare for Laying Hens

    PubMed Central

    Edgar, Joanne L.; Mullan, Siobhan M.; Pritchard, Joy C.; McFarlane, Una J. C.; Main, David C. J.

    2013-01-01

    Simple Summary Farm animals can be said to have a ‘good life’ if their quality of life is substantially higher than the current legal minimum and includes positive experiences such as pleasure. In commercial farms, animals can be provided with different resources such as bedding, exercise areas and enrichment objects. We used scientific evidence and expert opinion to determine which resources laying hens need to contribute to a ‘good life’. These resources were organised into three tiers, of increasing welfare, leading towards a ‘good life’. We describe how we developed the resource tiers and suggest how the overall framework might be used to promote a ‘good life’ for farm animals. Abstract The concept of a ‘good life’ recognises the distinction that an animal’s quality of life is beyond that of a ‘life worth living’, representing a standard of welfare substantially higher than the legal minimum (FAWC, 2009). We propose that the opportunities required for a ‘good life’ could be used to structure resource tiers that lead to positive welfare and are compatible with higher welfare farm assurance schemes. Published evidence and expert opinion was used to define three tiers of resource provision (Welfare +, Welfare ++ and Welfare +++) above those stipulated in UK legislation and codes of practice, which should lead to positive welfare outcomes. In this paper we describe the principles underpinning the framework and the process of developing the resource tiers for laying hens. In doing so, we summarise expert opinion on resources required to achieve a ‘good life’ in laying hens and discuss the philosophical and practical challenges of developing the framework. We present the results of a pilot study to establish the validity, reliability and feasibility of the draft laying hen tiers on laying hen production systems. Finally, we propose a generic welfare assessment framework for farm animals and suggest directions for implementation

  1. Development and application of a two-tier diagnostic test measuring college biology students' understanding of diffusion and osmosis after a course of instruction

    NASA Astrophysics Data System (ADS)

    Odom, Arthur Louis; Barrow, Lloyd H.

    This study involved the development and application of a two-tier diagnostic test measuring college biology students' understanding of diffusion and osmosis after a course of instruction. The development procedure had three general steps: defining the content boundaries of the test, collecting information on students' misconceptions, and instrument development. Misconception data were collected from interviews and multiple-choice questions with free response answers. The data were used to develop 12 two-tier multiple choice items in which the first tier examined content knowledge and the second examined understanding of that knowledge. The conceptual knowledge examined was the particulate and random nature of matter, concentration and tonicity, the influence of life forces on diffusion and osmosis, membranes, kinetic energy of matter, the process of diffusion, and the process of osmosis. The diagnostic instrument was administered to 240 students (123 non-biology majors and 117 biology majors) enrolled in a college freshman biology laboratory course. The students had completed a unit on diffusion and osmosis. The content taught was carefully defined by propositional knowledge statements, and was the same content that defined the content boundaries of the test. The split-half reliability was .74. Difficulty indices ranged from 0.23 to 0.95, and discrimination indices ranged from 0.21 to 0.65. Each item was analyzed to determine student understanding of, and identify misconceptions about, diffusion and osmosis.Received: 18 June 1993; Revised: 16 February 1994;

  2. INFN Tier-1 Testbed Facility

    NASA Astrophysics Data System (ADS)

    Gregori, Daniele; Cavalli, Alessandro; dell'Agnello, Luca; Dal Pra, Stefano; Prosperini, Andrea; Ricci, Pierpaolo; Ronchieri, Elisabetta; Sapunenko, Vladimir

    2012-12-01

    INFN-CNAF, located in Bologna, is the Information Technology Center of National Institute of Nuclear Physics (INFN). In the framework of the Worldwide LHC Computing Grid, INFN-CNAF is one of the eleven worldwide Tier-1 centers to store and reprocessing Large Hadron Collider (LHC) data. The Italian Tier-1 provides the resources of storage (i.e., disk space for short term needs and tapes for long term needs) and computing power that are needed for data processing and analysis to the LHC scientific community. Furthermore, INFN Tier-1 houses computing resources for other particle physics experiments, like CDF at Fermilab, SuperB at Frascati, as well as for astro particle and spatial physics experiments. The computing center is a very complex infrastructure, the hardaware layer include the network, storage and farming area, while the software layer includes open source and proprietary software. Software updating and new hardware adding can unexpectedly deteriorate the production activity of the center: therefore a testbed facility has been set up in order to reproduce and certify the various layers of the Tier-1. In this article we describe the testbed and the checks performed.

  3. Development of an early-tier laboratory bioassay for assessing the impact of orally-active insecticidal compounds on larvae of Coccinella septempunctata (Coleoptera: Coccinellidae).

    PubMed

    Alvarez-Alfageme, Fernando; Pálinkás, Zoltan; Bigler, Franz; Romeis, Jörg

    2012-12-01

    Early-tier studies are the initial step in the environmental risk assessment of genetically engineered plants on nontarget arthropods. They are conducted in the laboratory where surrogate species are exposed to higher concentrations of the arthropod-active compound than those expected to occur in the field. Thus, early-tier tests provide robust data and allow to make general conclusions about the susceptibility of the surrogate to the test substance. We have developed an early-tier test for assessing the toxicity of orally-active insecticidal compounds to larvae of the ladybird beetle Coccinella septempunctata L. (Coleoptera: Coccinellidae). Using potassium arsenate and the protease inhibitor E-64 as model compounds, we validated the bioassay set-up for C. septempunctata. Sucrose solution containing the test compound was offered to larvae for 24 h on the first day of each of its four larval instars. Subsequently, larvae were fed ad libitum with Ephestia kuehniella (Zeller) (Lepidoptera: Pyralidae) eggs. Both compounds negatively affected C. septempunctata larval survival and development, and adult weight, indicating that the bioassay setup was able to detect dietary effects of insecticidal substances on the ladybird. Power analyses revealed that sample sizes of 20 or 45 per treatment are sufficient to detect 50 or 20% differences between the control and treatment groups, respectively, for the various measurement endpoints. PMID:23321119

  4. Strength-Based RTI: Conceptualizing a Multi-Tiered System for Developing Gifted Potential

    ERIC Educational Resources Information Center

    Bianco, Margarita

    2010-01-01

    This article explores the possibilities of a strength-based Response to Intervention (RTI) model for developing and identifying gifted potential. Although much has been written about the promises and challenges of RTI in recent years, the utility of RTI for meeting the needs of gifted learners has not been fully explored. This article seeks to…

  5. The Development and Validation of a Two-Tiered Multiple-Choice Instrument to Identify Alternative Conceptions in Earth Science

    ERIC Educational Resources Information Center

    Mangione, Katherine Anna

    2010-01-01

    This study was to determine reliability and validity for a two-tiered, multiple- choice instrument designed to identify alternative conceptions in earth science. Additionally, this study sought to identify alternative conceptions in earth science held by preservice teachers, to investigate relationships between self-reported confidence scores and…

  6. Developing an Educational Computer Game for Migratory Bird Identification Based on a Two-Tier Test Approach

    ERIC Educational Resources Information Center

    Chu, Hui-Chun; Chang, Shao-Chen

    2014-01-01

    Although educational computer games have been recognized as being a promising approach, previous studies have indicated that, without supportive models, students might only show temporary interest during the game-based learning process, and their learning performance is often not as good as expected. Therefore, in this paper, a two-tier test…

  7. Development of methane emission factors for enteric fermentation in cattle from Benin using IPCC Tier 2 methodology.

    PubMed

    Kouazounde, J B; Gbenou, J D; Babatounde, S; Srivastava, N; Eggleston, S H; Antwi, C; Baah, J; McAllister, T A

    2015-03-01

    The objective of this study was to develop emission factors (EF) for methane (CH4) emissions from enteric fermentation in cattle native to Benin. Information on livestock characteristics and diet practices specific to the Benin cattle population were gathered from a variety of sources and used to estimate EF according to Tier 2 methodology of the 2006 Intergovernmental Panel on Climate Change (IPCC) Guidelines for National Greenhouse Gas Inventories. Most cattle from Benin are Bos taurus represented by Borgou, Somba and Lagune breeds. They are mainly multi-purpose, being used for production of meat, milk, hides and draft power and grazed in open pastures and crop lands comprising tropical forages and crops. Estimated enteric CH4 EFs varied among cattle breeds and subcategory owing to differences in proportions of gross energy intake expended to meet maintenance, production and activity. EFs ranged from 15.0 to 43.6, 16.9 to 46.3 and 24.7 to 64.9 kg CH4/head per year for subcategories of Lagune, Somba and Borgou cattle, respectively. Average EFs for cattle breeds were 24.8, 29.5 and 40.2 kg CH4/head per year for Lagune, Somba and Borgou cattle, respectively. The national EF for cattle from Benin was 39.5 kg CH4/head per year. This estimated EF was 27.4% higher than the default EF suggested by IPCC for African cattle with the exception of dairy cattle. The outcome of the study underscores the importance of obtaining country-specific EF to estimate global enteric CH4 emissions. PMID:25385068

  8. Tier 1 and Tier 2 Early Intervention for Handwriting and Composing

    ERIC Educational Resources Information Center

    Berninger, Virginia W.; Rutberg, Judith E.; Abbott, Robert D.; Garcia, Noelia; Anderson-Youngstrom, Marci; Brooks, Allison; Fulton, Cynthia

    2006-01-01

    Three studies evaluated Tier 1 early intervention for handwriting at a critical period for literacy development in first grade and one study evaluated Tier 2 early intervention in the critical period between third and fourth grades for composing on high stakes tests. The results contribute to knowledge of research-supported handwriting and…

  9. Tier 2 safety Basis Document for the B151 Complex (B151, B152, and B154)

    SciTech Connect

    Cooper, G A

    2006-12-07

    This Safety Basis Document (SBD) has been prepared for the B151 Complex at Site 200 to meet the current contractual requirements at Lawrence Livermore National Laboratory (LLNL). B151 Complex consists of three separate complex and distinct buildings: B151, B152, and B154, represented within this document as facility segments. Based upon its chemical and radiological inventories, Segment B151 is classified as a Low Hazard facility segment. All other hazards associated with Segment B151 operations have been determined to be LSI. Based upon their inventories, Segment B152 and Segment B154 are each classified as LSI facility segments. However, for operational flexibility involving radiological materials, CMS chooses to classify each of these as Low Hazard facility segments. Changes in operations, maximum inventories, materials, or release potential that could result in larger consequences, or that could negatively impact the safety of the facility, will necessitate a re-evaluation of these facility classifications. This SBD is governed by the LLNL Non-Nuclear Work Smart Standards (WSSs) requirements including the ES&H Manual, Document 3.1, Non-Nuclear Safety Basis Program [LLNL, 2004a] and the DOE Explosives Safety Manual (ESM) [LLNL, 2004b]. This SBD demonstrates that the three segments of B151 Complex can be operated as Low Hazard facility segments without undue risks to co-located workers, the public, or the environment. This SBD: (1) Provides a systematic identification of the safety and health hazards associated with operations in the B151 Complex, (2) Compares facility inventories of explosives, biological materials, chemicals, radioisotopes with LLNL threshold values for each facility hazard classification criteria, (3) Examines standard and non-standard industrial hazards, (4) Examines the hazards of greatest significance, (5) Qualitatively discusses the programs that evaluate and control these hazards to ensure the protection of co-located workers, the public

  10. Development and use of a three-tier diagnostic test to assess high school students' misconceptions about the photoelectric effect

    NASA Astrophysics Data System (ADS)

    Taslidere, Erdal

    2016-05-01

    Background: In the last few decades, researchers have turned their attention to students' understanding of scientific concepts at different school levels. The results indicate that the learners have different ideas, and most of them are inaccurate in terms of those generally accepted by the scientific community. Purpose: This study was undertaken to describe the development, validation and use of a three-tier multiple-choice diagnostic test (PEMT) to reveal Turkish high school students' common misconceptions in terms of the photoelectric effect. Sample: In this study, 243 students (male=86, female=137) from six high schools made up the sample which comprised approximately 76% of the 11th grade population. Design and Methods: Based on findings from the literature, open-ended questions and interviews, the PEMT was developed and administered to 243 students. The data was analysed descriptively. Results: The Cronbach's alpha reliability coefficient of the scores was estimated as .83. Construct, content and face validities were established by senior experts and through the use of statistical techniques. The findings denoted that the test is a valid and reliable measure of students' qualitative understanding of the photoelectric concept. The results revealed that the majority of the students demonstrated a limited understanding of the photoelectric effect and have five prevalent misconceptions. These are: (1) an increase in intensity would provide the photon with enough energy to release electrons; (2) the photoelectric effect results from the ionization of atoms through the interaction with light; (3) a light beam whose photons have smaller energies than the work function would release electrons with the help of a voltage source; (4) the number of photoelectrons depends on the energy of the photon and (5) the photon has kinetic energy and it depends on the colour of light. The last two misconceptions were discovered in the current study. Conclusion: The findings

  11. Development and Application of a Novel Rasch-based Methodology for Evaluating Multi-Tiered Assessment Instruments: Validation and utilization of an undergraduate diagnostic test of the water cycle

    NASA Astrophysics Data System (ADS)

    Romine, William L.; Schaffer, Dane L.; Barrow, Lloyd

    2015-11-01

    We describe the development and validation of a three-tiered diagnostic test of the water cycle (DTWC) and use it to evaluate the impact of prior learning experiences on undergraduates' misconceptions. While most approaches to instrument validation take a positivist perspective using singular criteria such as reliability and fit with a measurement model, we extend this to a multi-tiered approach which supports multiple interpretations. Using a sample of 130 undergraduate students from two colleges, we utilize the Rasch model to place students and items along traditional one-, two-, and three-tiered scales as well as a misconceptions scale. In the three-tiered and misconceptions scales, high confidence was indicative of mastery. In the latter scale, a 'misconception' was defined as mastery of an incorrect concept. We found that integrating confidence into mastery did little to change item functioning; however, three-tiered usage resulted in higher reliability and lower student ability estimates than two-tiered usage. The misconceptions scale showed high efficacy in predicting items on which particular students were likely to express misconceptions, and revealed several tenacious misconceptions that all students were likely to express regardless of ability. Previous coursework on the water cycle did little to change the prevalence of undergraduates' misconceptions.

  12. Multi-tier approach for data acquisition programming in the TJ-II remote participation system

    NASA Astrophysics Data System (ADS)

    Vega, J.; Sánchez, E.; Portas, A.; Ruiz, M.; Barrera, E.; López, S.

    2004-10-01

    Programming software to setup acquisition channels during device operation has been developed for the TJ-II remote participation system. The software follows a three-tier model. A first tier (client tier) groups client software containing only user interface code. A second tier (middle tier) includes code for authorization, authentication, and query processing. A third tier (data tier) consists of a relational database server for managing configurations. Multi-platform characteristics are provided by web browsers (client tier) and web servers (middle tier). This architecture avoids that data acquisition system controllers provide access control, database support, or graphic user interface resources. Therefore, computation capabilities of these systems can mainly be devoted to data handling. LabView (from National Instruments) has been used as programming language in the acquisition systems. This design allows a very transparent management of signals, independently on hardware modules and systems.

  13. 24 CFR 58.15 - Tiering.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Tiering. 58.15 Section 58.15 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development... development or when site-specific analysis or mitigation is not currently feasible and a more narrow...

  14. Development and Application of a Novel Rasch-Based Methodology for Evaluating Multi-Tiered Assessment Instruments: Validation and Utilization of an Undergraduate Diagnostic Test of the Water Cycle

    ERIC Educational Resources Information Center

    Romine, William L.; Schaffer, Dane L.; Barrow, Lloyd

    2015-01-01

    We describe the development and validation of a three-tiered diagnostic test of the water cycle (DTWC) and use it to evaluate the impact of prior learning experiences on undergraduates' misconceptions. While most approaches to instrument validation take a positivist perspective using singular criteria such as reliability and fit with a measurement…

  15. Organ Donation Among Tiers of Health Workers: Expanding Resources to Optimize Organ Availability in a Developing Country

    PubMed Central

    Oluyombo, Rotimi; Fawale, Bimbo Michael; Busari, Olusegun Adesola; Ogunmola, Jeffery Olarinde; Olanrewaju, Timothy Olusegun; Akinleye, Callistus Adewale; Ojewola, Rufus Wale; Yusuf, Musah; Obajolowo, Omotola; Soje, Michael; Gbadegesin, Babajide

    2016-01-01

    The global increase in end organ failure but disproportional shortage of organ donation calls for attention. Expanding the organ pool by assessing and improving health workers' attitude at all levels of care may be a worthwhile initiative. Methods A questionnaire-based cross sectional study involving tertiary, secondary, and primary health institutions in Southwestern Nigeria was conducted. Results Age range was 18 to 62 (36.7 ± 9.2) years. Only 13.5%, 11.7%, and 11.2% from primary, secondary, and tertiary health centers, respectively, would definitely donate despite high level of awareness (>90%) at each level of care. Participants from primary health care are of low income (P < 0.05), and this cohort is less likely to be aware of organ donation (P < 0.05). At each level of care, permission by religion to donate organs influenced positive attitudes (willingness to donate, readiness to counsel families of potential donors, and signing of organ donation cards) toward organ donation. Good knowledge of organ donation only significantly influenced readiness to counsel donors (P < 0.05) and not willingness to donate (P > 0.05). At each level of health care, young health care workers (P < 0.05) and women (P > 0.05) would be willing to donate, whereas men show positive attitude in signing of organ donor cards (P < 0.05) and counseling of families of potential donors (P > 0.05). Conclusions Knowledge and willingness to donate organs among health care levels were not different. Considering the potential advantage of community placement of other tiers of health care (primary and secondary) in Nigeria, integrating them would be strategically beneficial to organ donation. PMID:27500245

  16. Using Three-Tier Diagnostic Test to Assess Students' Misconceptions of States of Matter

    ERIC Educational Resources Information Center

    Kirbulut, Zubeyde Demet; Geban, Omer

    2014-01-01

    This study involves the development of a three-tier diagnostic test to measure high school students' understanding of states of matter concepts. The States of Matter Diagnostic Test (SMDT) is a 19-item three-tier diagnostic test consisting of three-tier items for assessing students' understanding of states of matter concepts. The SMDT…

  17. Status and Trends in Networking at LHC Tier1 Facilities

    NASA Astrophysics Data System (ADS)

    Bobyshev, A.; DeMar, P.; Grigaliunas, V.; Bigrow, J.; Hoeft, B.; Reymund, A.

    2012-12-01

    The LHC is entering its fourth year of production operation. Most Tier1 facilities have been in operation for almost a decade, when development and ramp-up efforts are included. LHC's distributed computing model is based on the availability of high capacity, high performance network facilities for both the WAN and LAN data movement, particularly within the Tier1 centers. As a result, the Tier1 centers tend to be on the leading edge of data center networking technology. In this paper, we analyze past and current developments in Tier1 LAN networking, as well as extrapolating where we anticipate networking technology is heading. Our analysis will include examination into the following areas: • Evolution of Tier1 centers to their current state • Evolving data center networking models and how they apply to Tier1 centers • Impact of emerging network technologies (e.g. 10GE-connected hosts, 40GE/100GE links, IPv6) on Tier1 centers • Trends in WAN data movement and emergence of software-defined WAN network capabilities • Network virtualization

  18. Increasing Complexity of Vaccine Development.

    PubMed

    Plotkin, Stanley A

    2015-07-15

    Vaccines already developed have been enormously successful. However, the development of future vaccines requires solution of a number of immunologic problems, including pathogen variability, short effector memory, evoking functional responses, and identification of antigens that generate protective responses. In addition, different populations may respond differently to the same vaccine because of genetic, age, or environmental factors.

  19. 47 CFR 76.922 - Rates for the basic service tier and cable programming services tiers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... programming services tiers. 76.922 Section 76.922 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... § 76.922 Rates for the basic service tier and cable programming services tiers. (a) Basic and cable programming service tier rates. Basic service tier and cable programming service rates shall be subject...

  20. 47 CFR 76.922 - Rates for the basic service tier and cable programming services tiers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... programming services tiers. 76.922 Section 76.922 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... § 76.922 Rates for the basic service tier and cable programming services tiers. (a) Basic and cable programming service tier rates. Basic service tier and cable programming service rates shall be subject...

  1. 47 CFR 76.922 - Rates for the basic service tier and cable programming services tiers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... programming services tiers. 76.922 Section 76.922 Telecommunication FEDERAL COMMUNICATIONS COMMISSION... § 76.922 Rates for the basic service tier and cable programming services tiers. (a) Basic and cable programming service tier rates. Basic service tier and cable programming service rates shall be subject...

  2. Setting up a STAR Tier 2 Site at Golias/Prague Farm

    NASA Astrophysics Data System (ADS)

    Chaloupka, Petr; Jakl, Pavel; Kapitán, Jan; Zerola, Michal; Lauret, Jérôme; STAR Collaboration

    2010-04-01

    High Energy Nuclear Physics (HENP) collaborations' experience show that the computing resources available at a single site are often neither sufficient nor satisfy the need of remote collaborators eager to carry their analysis in the fastest and most convenient way. From latencies in the network connectivity to the lack of interactivity, work at distant computing centers is often inefficient. Having fully functional software stack on local resources is a strong enabler of science opportunities for any local group who can afford the time investment. The situation becomes more complex as vast amount of data are often needed to perform meaningful analysis. Prague's heavy-ions group participating in STAR experiment at RHIC has been a strong advocate of local computing as the most efficient means of data processing and physics analyses. To create an environment where science can freely thrive, a Tier 2 computing center was set up at a Regional Computing Center for Particle Physics called "Golias". It is the biggest farm in the Czech Republic fully dedicated for particle physics experiments. We report on our experience in setting up a fully functional Tier 2 center leveraging the minimal locally available human and financial resources. We discuss the solutions chosen to address storage space and analysis issues and the impact on the farms overall functionality. This includes a locally built STAR analysis framework, integration with a local DPM system (a cost effective storage solution), the influence of the availability and quality of the network connection to Tier 0 via a dedicated CESNET/ESnet link and the development of light-weight yet fully automated data transfer tools allowing the movement of entire datasets from BNL (Tier 0) to Golias (Tier 2). We will summarize the impact of the gained computing performance on the efficiency of the local physics group at offline physics analysis and show the feasibility of such a solution that can used by other groups as well.

  3. Implementation of Grid Tier 2 and Tier 3 facilities on a Distributed OpenStack Cloud

    NASA Astrophysics Data System (ADS)

    Limosani, Antonio; Boland, Lucien; Coddington, Paul; Crosby, Sean; Huang, Joanna; Sevior, Martin; Wilson, Ross; Zhang, Shunde

    2014-06-01

    The Australian Government is making a AUD 100 million investment in Compute and Storage for the academic community. The Compute facilities are provided in the form of 30,000 CPU cores located at 8 nodes around Australia in a distributed virtualized Infrastructure as a Service facility based on OpenStack. The storage will eventually consist of over 100 petabytes located at 6 nodes. All will be linked via a 100 Gb/s network. This proceeding describes the development of a fully connected WLCG Tier-2 grid site as well as a general purpose Tier-3 computing cluster based on this architecture. The facility employs an extension to Torque to enable dynamic allocations of virtual machine instances. A base Scientific Linux virtual machine (VM) image is deployed in the OpenStack cloud and automatically configured as required using Puppet. Custom scripts are used to launch multiple VMs, integrate them into the dynamic Torque cluster and to mount remote file systems. We report on our experience in developing this nation-wide ATLAS and Belle II Tier 2 and Tier 3 computing infrastructure using the national Research Cloud and storage facilities.

  4. Tier II Interventions within the Framework of School-Wide Positive Behavior Support: Essential Features for Design, Implementation, and Maintenance

    PubMed Central

    Anderson, Cynthia M; Borgmeier, Chris

    2010-01-01

    To meet the complex social behavioral and academic needs of all students, schools benefit from having available multiple evidence-based interventions of varying intensity. School-wide positive behavior support provides a framework within which a continuum of evidence-based interventions can be implemented in a school. This framework includes three levels or tiers of intervention; Tier I (primary or universal), Tier II (secondary or targeted), and Tier III (tertiary or individualized) supports. In this paper we review the logic behind school-wide positive behavior support and then focus on Tier II interventions, as this level of support has received the least attention in the literature. We delineate the key features of Tier II interventions as implemented within school-wide positive behavior support, provide guidelines for matching Tier II interventions to school and student needs, and describe how schools plan for implementation and maintenance of selected interventions. PMID:22479670

  5. Identifying tier one key suppliers.

    PubMed

    Wicks, Steve

    2013-01-01

    In today's global marketplace, businesses are becoming increasingly reliant on suppliers for the provision of key processes, activities, products and services in support of their strategic business goals. The result is that now, more than ever, the failure of a key supplier has potential to damage reputation, productivity, compliance and financial performance seriously. Yet despite this, there is no recognised standard or guidance for identifying a tier one key supplier base and, up to now, there has been little or no research on how to do so effectively. This paper outlines the key findings of a BCI-sponsored research project to investigate good practice in identifying tier one key suppliers, and suggests a scalable framework process model and risk matrix tool to help businesses effectively identify their tier one key supplier base. PMID:23615061

  6. Identifying tier one key suppliers.

    PubMed

    Wicks, Steve

    2013-01-01

    In today's global marketplace, businesses are becoming increasingly reliant on suppliers for the provision of key processes, activities, products and services in support of their strategic business goals. The result is that now, more than ever, the failure of a key supplier has potential to damage reputation, productivity, compliance and financial performance seriously. Yet despite this, there is no recognised standard or guidance for identifying a tier one key supplier base and, up to now, there has been little or no research on how to do so effectively. This paper outlines the key findings of a BCI-sponsored research project to investigate good practice in identifying tier one key suppliers, and suggests a scalable framework process model and risk matrix tool to help businesses effectively identify their tier one key supplier base.

  7. Can complexity science inform physician leadership development?

    PubMed

    Grady, Colleen Marie

    2016-07-01

    Purpose The purpose of this paper is to describe research that examined physician leadership development using complexity science principles. Design/methodology/approach Intensive interviewing of 21 participants and document review provided data regarding physician leadership development in health-care organizations using five principles of complexity science (connectivity, interdependence, feedback, exploration-of-the-space-of-possibilities and co-evolution), which were grouped in three areas of inquiry (relationships between agents, patterns of behaviour and enabling functions). Findings Physician leaders are viewed as critical in the transformation of healthcare and in improving patient outcomes, and yet significant challenges exist that limit their development. Leadership in health care continues to be associated with traditional, linear models, which are incongruent with the behaviour of a complex system, such as health care. Physician leadership development remains a low priority for most health-care organizations, although physicians admit to being limited in their capacity to lead. This research was based on five principles of complexity science and used grounded theory methodology to understand how the behaviours of a complex system can provide data regarding leadership development for physicians. The study demonstrated that there is a strong association between physician leadership and patient outcomes and that organizations play a primary role in supporting the development of physician leaders. Findings indicate that a physician's relationship with their patient and their capacity for innovation can be extended as catalytic behaviours in a complex system. The findings also identified limiting factors that impact physicians who choose to lead, such as reimbursement models that do not place value on leadership and medical education that provides minimal opportunity for leadership skill development. Practical Implications This research provides practical

  8. 32 CFR 989.10 - Tiering.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ANALYSIS PROCESS (EIAP) § 989.10 Tiering. The Air Force should use tiered (40 CFR 1502.20) environmental... the same issues and to focus on the issues relating to specific actions. If the Air Force...

  9. 7 CFR 1940.327 - Tiering.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... successor agency under Public Law 103-354 may consider the concept of tiering in the preparation of... issues specific to the action under consideration. Tiering can be used when the sequence of analysis...

  10. A tiered-layered-staged model for informed consent in personal genome testing.

    PubMed

    Bunnik, Eline M; Janssens, A Cecile J W; Schermer, Maartje H N

    2013-06-01

    In recent years, developments in genomics technologies have led to the rise of commercial personal genome testing (PGT): broad genome-wide testing for multiple diseases simultaneously. While some commercial providers require physicians to order a personal genome test, others can be accessed directly. All providers advertise directly to consumers and offer genetic risk information about dozens of diseases in one single purchase. The quantity and the complexity of risk information pose challenges to adequate pre-test and post-test information provision and informed consent. There are currently no guidelines for what should constitute informed consent in PGT or how adequate informed consent can be achieved. In this paper, we propose a tiered-layered-staged model for informed consent. First, the proposed model is tiered as it offers choices between categories of diseases that are associated with distinct ethical, personal or societal issues. Second, the model distinguishes layers of information with a first layer offering minimal, indispensable information that is material to all consumers, and additional layers offering more detailed information made available upon request. Finally, the model stages informed consent as a process by feeding information to consumers in each subsequent stage of the process of undergoing a test, and by accommodating renewed consent for test result updates, resulting from the ongoing development of the science underlying PGT. A tiered-layered-staged model for informed consent with a focus on the consumer perspective can help overcome the ethical problems of information provision and informed consent in direct-to-consumer PGT.

  11. Do Schools with Adequate Tier I SWPBIS Implementation Have Stronger Implementation at Tiers II and III?

    ERIC Educational Resources Information Center

    Kim, Jerin; McIntosh, Kent; Hoselton, Rob

    2014-01-01

    To illustrate the three-tiered model, Tier I (universal) supports are delivered similarly to all students in all settings, and at least 80% of students are expected to respond to these supports. Beyond universal supports, Tier II (targeted) supports serve 10-15% of students whose behavior does not respond to Tier I supports. A small group of…

  12. 40 CFR 1508.28 - Tiering.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Tiering. 1508.28 Section 1508.28 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY TERMINOLOGY AND INDEX § 1508.28 Tiering. Tiering refers to the coverage of general matters in broader environmental impact statements (such as...

  13. 40 CFR 1502.20 - Tiering.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Tiering. 1502.20 Section 1502.20 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY ENVIRONMENTAL IMPACT STATEMENT § 1502.20 Tiering. Agencies are encouraged to tier their environmental impact statements to eliminate repetitive...

  14. 6 CFR 27.220 - Tiering.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Tiering. 27.220 Section 27.220 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Chemical Facility Security Program § 27.220 Tiering. (a) Preliminary Determination of Risk-Based Tiering. Based...

  15. Perceived stimulus complexity and food preference development.

    PubMed

    Lévy, C M; MacRae, A; Köster, E P

    2006-11-01

    The importance of perceived complexity, a "collative property" as defined by [Berlyne, D. E. (1967). Arousal and reinforcement. In Nebraska symposium on motivation (pp. 1-110). University of Nebraska Press], to the dynamic development of preference was investigated. Eighty-six female and 82 male subjects rated their liking for and various collative properties of seven very similar orange drinks that differed only in perceived complexity as a result of adding small quantities of other flavours. This was done before and after giving each subject extended experience of one of the drinks, each being used equally often for this purpose. As predicted by the theory of [Dember, W. N., & Earl, R. W. (1957). Analysis of exploratory, manipulatory and curiosity behavior. Psychological Review, 64 (2), 91-96] exposure to a stimulus with a slightly higher complexity than an individual subject's optimally preferred level of perceived complexity, caused an upwards shift in that level, whereas exposure to a less complex stimulus had no such effect. Changes in the appreciation of the drinks predicted by the theory were also observed.

  16. Speech-Language Pathologist and General Educator Collaboration: A Model for Tier 2 Service Delivery

    ERIC Educational Resources Information Center

    Watson, Gina D.; Bellon-Harn, Monica L.

    2014-01-01

    Tier 2 supplemental instruction within a response to intervention framework provides a unique opportunity for developing partnerships between speech-language pathologists and classroom teachers. Speech-language pathologists may participate in Tier 2 instruction via a consultative or collaborative service delivery model depending on district needs.…

  17. Exploring Students' Understanding of Electrochemical Cells Using an Enhanced Two-Tier Diagnostic Instrument

    ERIC Educational Resources Information Center

    Loh, Adrian Sin Loy; Subramaniam, R.; Tan, Kim Chwee Daniel

    2014-01-01

    Background: The development of two-tier multiple-choice questions has permitted the diagnosis of students' understanding on various topics in the sciences as well as helped to ascertain the alternative conceptions they have. A limitation of two-tier diagnostic instruments that has been noted in the literature, but which has not been…

  18. XENOENDOCRINE DISRUPTERS-TIERED SCREENING AND TESTING: FILLING KEY DATA GAPS

    EPA Science Inventory

    The US Environmental Protection Agency (EPA) is developing a screening and testing program for endocrine disrupting chemicals (EDCs). High priority chemicals would be evaluated in the Tier 1 Screening (T1S) battery. Chemicals positive in T1S would then be tested (Tier 2). T1S...

  19. A Four-Tier Differentiation Model: Engage All Students in the Learning Process

    ERIC Educational Resources Information Center

    Herrelko, Janet M.

    2013-01-01

    This study details the creation of a four-tiered format designed to help preservice teachers write differentiated lesson plans. A short history of lesson plan differentiation models is described and how the four-tier approach was developed through collaboration with classroom teachers and university faculty. The unifying element for the format…

  20. Integrated Safety Analysis Tiers

    NASA Technical Reports Server (NTRS)

    Shackelford, Carla; McNairy, Lisa; Wetherholt, Jon

    2009-01-01

    Commercial partnerships and organizational constraints, combined with complex systems, may lead to division of hazard analysis across organizations. This division could cause important hazards to be overlooked, causes to be missed, controls for a hazard to be incomplete, or verifications to be inefficient. Each organization s team must understand at least one level beyond the interface sufficiently enough to comprehend integrated hazards. This paper will discuss various ways to properly divide analysis among organizations. The Ares I launch vehicle integrated safety analyses effort will be utilized to illustrate an approach that addresses the key issues and concerns arising from multiple analysis responsibilities.

  1. Exploring students' understanding of electrochemical cells using an enhanced two-tier diagnostic instrument

    NASA Astrophysics Data System (ADS)

    Sin Loy Loh, Adrian; Subramaniam, R.; Tan, Kim Chwee Daniel

    2014-09-01

    Background:The development of two-tier multiple-choice questions has permitted the diagnosis of students' understanding on various topics in the sciences as well as helped to ascertain the alternative conceptions they have. A limitation of two-tier diagnostic instruments that has been noted in the literature, but which has not been systematically explored, is that some questions can have a diagonal response. This can allow students to select a second-tier response based on cues from a particular response in the first tier, and it can limit the analytical utility of the diagnostic instrument to some extent. Purpose:The study explores an enhancement of the traditional two-tier diagnostic instrument to address diagonal response. In the format proposed, there are dual sections for both the answer and reason tiers. The answer tier is in dichotomous form and for each of the dichotomous responses, there are separate polytomous responses in the reason tier. Sample:There were 99 students of grade 10 level who participated in this study. Design and Method:The research design follows the usual approach adopted for the development of diagnostic instruments but with some modifications. The topic of electrochemical cells was chosen to evaluate the effectiveness of the enhanced format of the two-tier instrument. Results:It was found that with the enhanced format, the issue of diagonal response has been satisfactorily addressed. Also, a situation where students get the answer wrong but the reason correct, which is sometimes encountered in two-tier questions, does not arise with this format. The instrument has also been able to shed some light on the students' understanding of electrochemical cells and their alternative conceptions. Conclusions:The enhanced format of the two-tier instrument proposed in this study can also be used for the study of alternative conceptions in science education.

  2. Building a Tier 2 Intervention: A Glimpse behind the Data

    ERIC Educational Resources Information Center

    Kelley, Elizabeth S.; Goldstein, Howard

    2014-01-01

    This article highlights the development process and data-driven decisions that characterized a 5-year iterative process of development and evaluation of a Tier 2 early language curriculum, "Story Friends." This curriculum was specifically designed to be effective and feasible for high fidelity implementation in preschool settings.…

  3. Cormorant: Development of a complex field

    SciTech Connect

    Stiles, J.H.; McKee, J.W.

    1986-01-01

    The Cormorant Field provides an example of the numerous changes which are required to the development plan for a large, complex field as the nature of its complexity becomes better known. Changes in the basic development and displacement pattern, the number and spacing of wells, and completion method have occurred as the structural, stratigraphic and diagenetic nature of the field has been uncovered. In addition, a better understanding of a key development constraint, the drilling reach, has allowed changes with significant cost savings. While a well thought out initial development plan was formulated for the field, close surveillance of geological results and field performance has been necessary to allow its almost continuous updating. This paper discusses studies and evaluations undertaken by Esso Exporation and Production U.K. to evaluate such changes. In addition to a discussion of each of the four fault blocks comprising the field, the following are addressed: (1) the role of detailed reservoir description work, (2) use of partial perforation techniques for waterflood control, and (3) the tailoring of reservoir monitoring to the specific problems of Cormorant. These studies were done to complement work done by the operator, Shell U.K. Exploration and Production, who prepared the base development plan and subsequent updates.

  4. Final Tier 2 Environmental Impact Statement for International Space Station

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The Final Tier 2 Environmental Impact Statement (EIS) for the International Space Station (ISS) has been prepared by the National Aeronautics and Space Administration (NASA) and follows NASA's Record of Decision on the Final Tier 1 EIS for the Space Station Freedom. The Tier 2 EIS provides an updated evaluation of the environmental impacts associated with the alternatives considered: the Proposed Action and the No-Action alternative. The Proposed Action is to continue U.S. participation in the assembly and operation of ISS. The No-Action alternative would cancel NASA!s participation in the Space Station Program. ISS is an international cooperative venture between NASA, the Canadian Space Agency, the European Space Agency, the Science and Technology Agency of Japan, the Russian Space Agency, and the Italian Space Agency. The purpose of the NASA action would be to further develop human presence in space; to meet scientific, technological, and commercial research needs; and to foster international cooperation.

  5. Draft Tier 2 Environmental Impact Statement for International Space Station

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The Draft Tier 2 Environmental Impact Statement (EIS) for the International Space Station (ISS) has been prepared by the National Aeronautics and Space Administration (NASA) and follows NASA's Record of Decision on the Final Tier 1 EIS for the Space Station Freedom. The Tier 2 EIS provides an updated evaluation of the environmental impacts associated with the alternatives considered: the Proposed Action and the No-Action alternative. The Proposed Action is to continue U.S. participation in the assembly and operation of ISS. The No-Action alternative would cancel NASA's participation in the Space Station Program. ISS is an international cooperative venture between NASA, the Canadian Space Agency, the European Space Agency, the Science and Technology Agency of Japan, the Russian Space Agency, and the Italian Space Agency. The purpose of the NASA action would be to further develop a human presence in space; to meet scientific, technological, and commercial research needs; and to foster international cooperation.

  6. Emergent behaviour in a chlorophenol-mineralising three-tiered microbial ‘food web’

    PubMed Central

    Wade, M.J.; Pattinson, R.W.; Parker, N.G.; Dolfing, J.

    2016-01-01

    Anaerobic digestion enables the water industry to treat wastewater as a resource for generating energy and recovering valuable by-products. The complexity of the anaerobic digestion process has motivated the development of complex models. However, this complexity makes it intractable to pin-point stability and emergent behaviour. Here, the widely used Anaerobic Digestion Model No. 1 (ADM1) has been reduced to its very backbone, a syntrophic two-tiered microbial ‘food chain’ and a slightly more complex three-tiered microbial ‘food web’, with their stability analysed as a function of the inflowing substrate concentration and dilution rate. Parameterised for phenol and chlorophenol degradation, steady-states were always stable and non-oscillatory. Low input concentrations of chlorophenol were sufficient to maintain chlorophenol- and phenol-degrading populations but resulted in poor conversion and a hydrogen flux that was too low to sustain hydrogenotrophic methanogens. The addition of hydrogen and phenol boosted the populations of all three organisms, resulting in the counterintuitive phenomena that (i) the phenol degraders were stimulated by adding hydrogen, even though hydrogen inhibits phenol degradation, and (ii) the dechlorinators indirectly benefitted from measures that stimulated their hydrogenotrophic competitors; both phenomena hint at emergent behaviour. PMID:26551153

  7. Emergent behaviour in a chlorophenol-mineralising three-tiered microbial 'food web'.

    PubMed

    Wade, M J; Pattinson, R W; Parker, N G; Dolfing, J

    2016-01-21

    Anaerobic digestion enables the water industry to treat wastewater as a resource for generating energy and recovering valuable by-products. The complexity of the anaerobic digestion process has motivated the development of complex models. However, this complexity makes it intractable to pin-point stability and emergent behaviour. Here, the widely used Anaerobic Digestion Model No. 1 (ADM1) has been reduced to its very backbone, a syntrophic two-tiered microbial 'food chain' and a slightly more complex three-tiered microbial 'food web', with their stability analysed as a function of the inflowing substrate concentration and dilution rate. Parameterised for phenol and chlorophenol degradation, steady-states were always stable and non-oscillatory. Low input concentrations of chlorophenol were sufficient to maintain chlorophenol- and phenol-degrading populations but resulted in poor conversion and a hydrogen flux that was too low to sustain hydrogenotrophic methanogens. The addition of hydrogen and phenol boosted the populations of all three organisms, resulting in the counterintuitive phenomena that (i) the phenol degraders were stimulated by adding hydrogen, even though hydrogen inhibits phenol degradation, and (ii) the dechlorinators indirectly benefitted from measures that stimulated their hydrogenotrophic competitors; both phenomena hint at emergent behaviour. PMID:26551153

  8. Cormorant; Development of a complex field

    SciTech Connect

    Stiles, J.H. Jr.; McKee, J.W. )

    1991-12-01

    The development plan of Cormorant oil field exemplifies changes required as the nature of a large, complex field becomes better known. The number and locations of wells and the completion method have changed as the structural, stratigraphic, and diagnetic natures of the field became better known. A better understanding of a key development constraint-and drilling reach-has allowed changes to the development plan at significant cost savings. Close surveillance of geological results and field performance has been necessary to allow almost continuous updating. This paper discusses studies and evaluations undertaking by Eso E and P U.K. to evaluate such changes for each of the field's four fault blocks. These studies complemented work done by the operator, Shell U.K. E and P.

  9. Do Students Know What They Know and What They Don't Know? Using a Four-Tier Diagnostic Test to Assess the Nature of Students' Alternative Conceptions

    ERIC Educational Resources Information Center

    Caleon, Imelda S.; Subramaniam, R.

    2010-01-01

    This study reports on the development and application of a four-tier multiple-choice (4TMC) diagnostic instrument, which has not been reported in the literature. It is an enhanced version of the two-tier multiple-choice (2TMC) test. As in 2TMC tests, its answer and reason tiers measure students' content knowledge and explanatory knowledge,…

  10. Solid waste management complex site development plan

    SciTech Connect

    Greager, T.M.

    1994-09-30

    The main purpose of this Solid Waste Management Complex Site Development Plan is to optimize the location of future solid waste treatment and storage facilities and the infrastructure required to support them. An overall site plan is recommended. Further, a series of layouts are included that depict site conditions as facilities are constructed at the SWMC site. In this respect the report serves not only as the siting basis for future projects, but provides siting guidance for Project W-112, as well. The plan is intended to function as a template for expected growth of the site over the next 30 years so that future facilities and infrastructure will be properly integrated.

  11. Tier 3 DarkStar on Ramp

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The Lockheed Martin/Boeing Tier III- (minus) unpiloted aerial vehicle is inspected by NASA personnel September 14, 1995, following its arrival at the Dryden Flight Research Center, Edwards, California. The Tier III Minus project utilized Dryden ground facilities during the flight test program. The vehicle was developed by Lockheed Martin Skunk Works and Boeing Defense and Space Group to satisfy a goal of the Defense Airborne Reconnaissance Office (DARO) to supply responsive and sustained surveillance and reconnaissance data from anywhere within enemy territory, day or night, in all types of weather. Dubbed DarkStar, it had a wing span of 69 feet and was designed to fly above 45,000 feet at subsonic speeds on missions lasting more than eight hours. The first DarkStar prototype made its first flight on March 29, 1996. At the begininning of its second flight, on April 22, 1996, it crashed on takeoff, and was destroyed. The DarkStar's unusual shape was dictated by the requirement to orbit its target conducting surveillance while still remaining stealthy. Whereas aircraft like the F-117 are designed to be more stealthy from the front, the DarkStar is designed to be more stealthy from the sides.

  12. Ensuring Safety of Navigation: A Three-Tiered Approach

    NASA Astrophysics Data System (ADS)

    Johnson, S. D.; Thompson, M.; Brazier, D.

    2014-12-01

    The primary responsibility of the Hydrographic Department at the Naval Oceanographic Office (NAVOCEANO) is to support US Navy surface and sub-surface Safety of Navigation (SoN) requirements. These requirements are interpreted, surveys are conducted, and accurate products are compiled and archived for future exploitation. For a number of years NAVOCEANO has employed a two-tiered data-basing structure to support SoN. The first tier (Data Warehouse, or DWH) provides access to the full-resolution sonar and lidar data. DWH preserves the original data such that any scale product can be built. The second tier (Digital Bathymetric Database - Variable resolution, or DBDB-V) served as the final archive for SoN chart scale, gridded products compiled from source bathymetry. DBDB-V has been incorporated into numerous DoD tactical decision aids and serves as the foundation bathymetry for ocean modeling. With the evolution of higher density survey systems and the addition of high-resolution gridded bathymetry product requirements, a two-tiered model did not provide an efficient solution for SoN. The two-tiered approach required scientists to exploit full-resolution data in order to build any higher resolution product. A new perspective on the archival and exploitation of source data was required. This new perspective has taken the form of a third tier, the Navigation Surface Database (NSDB). NSDB is an SQLite relational database populated with International Hydrographic Organization (IHO), S-102 compliant Bathymetric Attributed Grids (BAGs). BAGs archived within NSDB are developed at the highest resolution that the collection sensor system can support and contain nodal estimates for depth, uncertainty, separation values and metadata. Gridded surface analysis efforts culminate in the generation of the source resolution BAG files and their storage within NSDB. Exploitation of these resources eliminates the time and effort needed to re-grid and re-analyze native source file formats.

  13. Middle School Students' Responses to Two-Tier Tasks

    ERIC Educational Resources Information Center

    Haja, Shajahan; Clarke, David

    2011-01-01

    The structure of two-tier testing is such that the first tier consists of a multiple-choice question and the second tier requires justifications for choices of answers made in the first tier. This study aims to evaluate two-tier tasks in "proportion" in terms of students' capacity to write and select justifications and to examine the effect of…

  14. 50 CFR 86.53 - What are funding tiers?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 9 2014-10-01 2014-10-01 false What are funding tiers? 86.53 Section 86... (BIG) PROGRAM How States Apply for Grants § 86.53 What are funding tiers? (a) This grant program will consist of two tiers of funding. (i) You may apply for one or both tiers. (ii) The two tiers will...

  15. 50 CFR 86.53 - What are funding tiers?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 9 2013-10-01 2013-10-01 false What are funding tiers? 86.53 Section 86... (BIG) PROGRAM How States Apply for Grants § 86.53 What are funding tiers? (a) This grant program will consist of two tiers of funding. (i) You may apply for one or both tiers. (ii) The two tiers will...

  16. Examining the Efficacy of a Tier 2 Kindergarten Mathematics Intervention

    ERIC Educational Resources Information Center

    Clarke, Ben; Doabler, Christian T.; Smolkowski, Keith; Baker, Scott K.; Fien, Hank; Cary, Mari Strand

    2016-01-01

    This study examined the efficacy of a Tier 2 kindergarten mathematics intervention program, ROOTS, focused on developing whole number understanding for students at risk in mathematics. A total of 29 classrooms were randomly assigned to treatment (ROOTS) or control (standard district practices) conditions. Measures of mathematics achievement were…

  17. Using Tiered Assignments to Engage Learners in Advanced Placement Physics

    ERIC Educational Resources Information Center

    Geddes, Kimberly A.

    2010-01-01

    This article presents lesson plans that incorporate tiered objectives and brainstorming techniques as means for differentiating instruction and ensuring that learners are challenged at levels commensurate with their abilities even though they are developing an understanding of the same physics concepts. A listing of materials and resources…

  18. Two-tier diagnosing in psychiatry.

    PubMed

    van Praag, H M

    1990-10-01

    This article addresses the question: what is the most productive way to systematize abnormal behavior in order to study its biological roots? Though nosology still occupies the premier position in biological psychiatry, it is, in and by itself, a treacherous beacon. Syndromal organization of psychopathology is likewise seriously flawed. A functional organization of psychopathology is considered the most appropriate framework for biological research and a plea is made for a two-tier diagnostic system of psychiatric disorders. Tier one comprises the nosological diagnosis, and tier two a detailed depiction of the component psychological dysfunctions. Such a two-tier diagnostic system would bring psychopathology onto a true scientific footing.

  19. Effects of Tier 2 and Tier 3 Mathematics Interventions for Second Graders with Mathematics Difficulties

    ERIC Educational Resources Information Center

    Dennis, Minyi Shih

    2015-01-01

    Two studies were conducted to examine the effects of Tier 2 and Tier 3 mathematics interventions on students with mathematics learning difficulties. In the first study, the work of Bryant et al. was replicated and expanded upon by documenting the sustained effects of a Tier 2 mathematics intervention on mathematics performance by second graders.…

  20. 47 CFR 76.922 - Rates for the basic service tier and cable programming services tiers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Rates for the basic service tier and cable programming services tiers. 76.922 Section 76.922 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Cable Rate Regulation § 76.922 Rates for the basic service tier...

  1. 47 CFR 76.922 - Rates for the basic service tier and cable programming services tiers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Rates for the basic service tier and cable programming services tiers. 76.922 Section 76.922 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Cable Rate Regulation § 76.922 Rates for the basic service tier...

  2. 40 CFR 79.54 - Tier 3.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... outcomes; (vii) The presence or absence of effective health test control data for base-fuel-only versus..., occupational, or epidemiological exposures. (b) Notice. (1) EPA will determine whether Tier 3 testing is... significant dose-related positive response as compared with appropriate controls. Alternatively, Tier...

  3. 40 CFR 1502.20 - Tiering.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY ENVIRONMENTAL IMPACT STATEMENT § 1502.20 Tiering. Agencies are encouraged to tier their environmental impact statements to eliminate repetitive discussions... review (§ 1508.28). Whenever a broad environmental impact statement has been prepared (such as a...

  4. 6 CFR 27.220 - Tiering.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Chemical Facility Security Program § 27.220 Tiering. (a) Preliminary Determination of Risk-Based Tiering. Based on... facility presents a high level of security risk, the Department shall notify a facility of the...

  5. 6 CFR 27.220 - Tiering.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Chemical Facility Security Program § 27.220 Tiering. (a) Preliminary Determination of Risk-Based Tiering. Based on... facility presents a high level of security risk, the Department shall notify a facility of the...

  6. 6 CFR 27.220 - Tiering.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Chemical Facility Security Program § 27.220 Tiering. (a) Preliminary Determination of Risk-Based Tiering. Based on... facility presents a high level of security risk, the Department shall notify a facility of the...

  7. 6 CFR 27.220 - Tiering.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Chemical Facility Security Program § 27.220 Tiering. (a) Preliminary Determination of Risk-Based Tiering. Based on... facility presents a high level of security risk, the Department shall notify a facility of the...

  8. A tiered-layered-staged model for informed consent in personal genome testing.

    PubMed

    Bunnik, Eline M; Janssens, A Cecile J W; Schermer, Maartje H N

    2013-06-01

    In recent years, developments in genomics technologies have led to the rise of commercial personal genome testing (PGT): broad genome-wide testing for multiple diseases simultaneously. While some commercial providers require physicians to order a personal genome test, others can be accessed directly. All providers advertise directly to consumers and offer genetic risk information about dozens of diseases in one single purchase. The quantity and the complexity of risk information pose challenges to adequate pre-test and post-test information provision and informed consent. There are currently no guidelines for what should constitute informed consent in PGT or how adequate informed consent can be achieved. In this paper, we propose a tiered-layered-staged model for informed consent. First, the proposed model is tiered as it offers choices between categories of diseases that are associated with distinct ethical, personal or societal issues. Second, the model distinguishes layers of information with a first layer offering minimal, indispensable information that is material to all consumers, and additional layers offering more detailed information made available upon request. Finally, the model stages informed consent as a process by feeding information to consumers in each subsequent stage of the process of undergoing a test, and by accommodating renewed consent for test result updates, resulting from the ongoing development of the science underlying PGT. A tiered-layered-staged model for informed consent with a focus on the consumer perspective can help overcome the ethical problems of information provision and informed consent in direct-to-consumer PGT. PMID:23169494

  9. A tiered asthma hazard characterization and exposure assessment approach for evaluation of consumer product ingredients.

    PubMed

    Maier, Andrew; Vincent, Melissa J; Parker, Ann; Gadagbui, Bernard K; Jayjock, Michael

    2015-12-01

    Asthma is a complex syndrome with significant consequences for those affected. The number of individuals affected is growing, although the reasons for the increase are uncertain. Ensuring the effective management of potential exposures follows from substantial evidence that exposure to some chemicals can increase the likelihood of asthma responses. We have developed a safety assessment approach tailored to the screening of asthma risks from residential consumer product ingredients as a proactive risk management tool. Several key features of the proposed approach advance the assessment resources often used for asthma issues. First, a quantitative health benchmark for asthma or related endpoints (irritation and sensitization) is provided that extends qualitative hazard classification methods. Second, a parallel structure is employed to include dose-response methods for asthma endpoints and methods for scenario specific exposure estimation. The two parallel tracks are integrated in a risk characterization step. Third, a tiered assessment structure is provided to accommodate different amounts of data for both the dose-response assessment (i.e., use of existing benchmarks, hazard banding, or the threshold of toxicological concern) and exposure estimation (i.e., use of empirical data, model estimates, or exposure categories). Tools building from traditional methods and resources have been adapted to address specific issues pertinent to asthma toxicology (e.g., mode-of-action and dose-response features) and the nature of residential consumer product use scenarios (e.g., product use patterns and exposure durations). A case study for acetic acid as used in various sentinel products and residential cleaning scenarios was developed to test the safety assessment methodology. In particular, the results were used to refine and verify relationships among tiered approaches such that each lower data tier in the approach provides a similar or greater margin of safety for a given

  10. Simulation concept of NICA-MPD-SPD Tier0-Tier1 computing facilities

    NASA Astrophysics Data System (ADS)

    Korenkov, V. V.; Nechaevskiy, A. V.; Ososkov, G. A.; Pryahina, D. I.; Trofomov, V. V.; Uzhinskiy, A. V.

    2016-09-01

    The simulation concept for grid-cloud services of contemporary HENP experiments of the Big Data scale was formulated in practicing the simulation system developed in LIT JINR Dubna. This system is intended to improve the efficiency of the design and development of a wide class of grid-cloud structures by using the work quality indicators of some real system to design and predict its evolution. For these purposes the simulation program is combined with a real monitoring system of the grid-cloud service through a special database (DB). The DB accomplishes acquisition and analysis of monitoring data to carry out dynamical corrections of the simulation. Such an approach allows us to construct a general model pattern which should not depend on a specific simulated object, while the parameters describing this object can be used as input to run the pattern. The simulation of some processes of the NICA-MPD-SPD Tier0-Tier1 distributed computing is considered as an example of our approach applications.

  11. The retromer complex in development and disease

    PubMed Central

    Wang, Shiuan; Bellen, Hugo J.

    2015-01-01

    The retromer complex is a multimeric protein complex involved in recycling proteins from endosomes to the trans-Golgi network or plasma membrane. It thus regulates the abundance and subcellular distribution of its cargo within cells. Studies using model organisms show that the retromer complex is involved in specific developmental processes. Moreover, a number of recent studies implicate aberrant retromer function in photoreceptor degeneration, Alzheimer's disease and Parkinson's disease. Here, and in the accompanying poster, we provide an overview of the molecular and cellular mechanisms of retromer-mediated protein trafficking, highlighting key examples of retromer function in vivo. PMID:26199408

  12. Optimal Resource Allocation under Fair QoS in Multi-tier Server Systems

    NASA Astrophysics Data System (ADS)

    Akai, Hirokazu; Ushio, Toshimitsu; Hayashi, Naoki

    Recent development of network technology realizes multi-tier server systems, where several tiers perform functionally different processing requested by clients. It is an important issue to allocate resources of the systems to clients dynamically based on their current requests. On the other hand, Q-RAM has been proposed for resource allocation in real-time systems. In the server systems, it is important that execution results of all applications requested by clients are the same QoS(quality of service) level. In this paper, we extend Q-RAM to multi-tier server systems and propose a method for optimal resource allocation with fairness of the QoS levels of clients’ requests. We also consider an assignment problem of physical machines to be sleep in each tier sothat the energy consumption is minimized.

  13. Examining the Efficacy of a Tier 2 Kindergarten Mathematics Intervention.

    PubMed

    Clarke, Ben; Doabler, Christian T; Smolkowski, Keith; Baker, Scott K; Fien, Hank; Strand Cary, Mari

    2016-01-01

    This study examined the efficacy of a Tier 2 kindergarten mathematics intervention program, ROOTS, focused on developing whole number understanding for students at risk in mathematics. A total of 29 classrooms were randomly assigned to treatment (ROOTS) or control (standard district practices) conditions. Measures of mathematics achievement were collected at pretest and posttest. Treatment and control students did not differ on mathematics assessments at pretest. Gain scores of at-risk intervention students were significantly greater than those of control peers, and the gains of at-risk treatment students were greater than the gains of peers not at risk, effectively reducing the achievement gap. Implications for Tier 2 mathematics instruction in a response to intervention (RtI) model are discussed.

  14. Examining the Efficacy of a Tier 2 Kindergarten Mathematics Intervention.

    PubMed

    Clarke, Ben; Doabler, Christian T; Smolkowski, Keith; Baker, Scott K; Fien, Hank; Strand Cary, Mari

    2016-01-01

    This study examined the efficacy of a Tier 2 kindergarten mathematics intervention program, ROOTS, focused on developing whole number understanding for students at risk in mathematics. A total of 29 classrooms were randomly assigned to treatment (ROOTS) or control (standard district practices) conditions. Measures of mathematics achievement were collected at pretest and posttest. Treatment and control students did not differ on mathematics assessments at pretest. Gain scores of at-risk intervention students were significantly greater than those of control peers, and the gains of at-risk treatment students were greater than the gains of peers not at risk, effectively reducing the achievement gap. Implications for Tier 2 mathematics instruction in a response to intervention (RtI) model are discussed. PMID:24944163

  15. Cautionary Notes on a Global Tiered Pricing Framework for Medicines

    PubMed Central

    Williams, Owain D.; Ooms, Gorik

    2015-01-01

    Recently, there has been a policy momentum toward creating a global tiered pricing framework, which would provide differentiated prices for medicines globally, based on each country’s capacity to pay. We studied the most influential proposals for a tiered pricing framework since the 1995 World Trade Organization’s Agreement on Trade-Related Aspects of Intellectual Property Rights. We synthesized 6 critical questions to be addressed for a global framework to function and explored the many challenges of implementation. Although we acknowledge that there is the potential for an exceptional global commitment that would benefit both producers and those in developing countries in need of wider access to medicines, our greatest concern is to ensure that a global framework does not price out the poor from pharmaceutical markets nor threaten current flexibilities within the international patent regime. PMID:25973806

  16. 40 CFR 87.23 - Exhaust emission standards for Tier 6 and Tier 8 engines.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Exhaust emission standards for Tier 6 and Tier 8 engines. 87.23 Section 87.23 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) Definitions. Exhaust Emissions (New Aircraft Gas Turbine Engines) §...

  17. 40 CFR 87.23 - Exhaust emission standards for Tier 6 and Tier 8 engines.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... standard, as described in § 87.60. The tier of standards identified for an engine relates to NOX emissions... the NOX emission standards. (a) New turboprop aircraft engines with rated output at or above 1,000... excepted without request from the otherwise applicable Tier 6 NOX emission standard. To be eligible...

  18. Fears for Tiers: Are Candidates Being Appropriately Rewarded for Their Performance in Tiered Examinations?

    ERIC Educational Resources Information Center

    Wheadon, Christopher; Beguin, Anton

    2010-01-01

    Tiering is a multi-stage test design whereby teachers allocate students to a particular difficulty level (tier) of a test. This approach to the challenge of delivering assessments to students with a heterogeneous ability distribution is normal practice in UK public examinations at the age of 16. This study uses Item Response Theory number-correct…

  19. The CMS Tier0 goes cloud and grid for LHC Run 2

    SciTech Connect

    Hufnagel, Dirk

    2015-12-23

    In 2015, CMS will embark on a new era of collecting LHC collisions at unprecedented rates and complexity. This will put a tremendous stress on our computing systems. Prompt Processing of the raw data by the Tier-0 infrastructure will no longer be constrained to CERN alone due to the significantly increased resource requirements. In LHC Run 2, we will need to operate it as a distributed system utilizing both the CERN Cloud-based Agile Infrastructure and a significant fraction of the CMS Tier-1 Grid resources. In another big change for LHC Run 2, we will process all data using the multi-threaded framework to deal with the increased event complexity and to ensure efficient use of the resources. Furthermore, this contribution will cover the evolution of the Tier-0 infrastructure and present scale testing results and experiences from the first data taking in 2015.

  20. The CMS Tier0 goes cloud and grid for LHC Run 2

    DOE PAGES

    Hufnagel, Dirk

    2015-12-23

    In 2015, CMS will embark on a new era of collecting LHC collisions at unprecedented rates and complexity. This will put a tremendous stress on our computing systems. Prompt Processing of the raw data by the Tier-0 infrastructure will no longer be constrained to CERN alone due to the significantly increased resource requirements. In LHC Run 2, we will need to operate it as a distributed system utilizing both the CERN Cloud-based Agile Infrastructure and a significant fraction of the CMS Tier-1 Grid resources. In another big change for LHC Run 2, we will process all data using the multi-threadedmore » framework to deal with the increased event complexity and to ensure efficient use of the resources. Furthermore, this contribution will cover the evolution of the Tier-0 infrastructure and present scale testing results and experiences from the first data taking in 2015.« less

  1. The CMS TierO goes Cloud and Grid for LHC Run 2

    NASA Astrophysics Data System (ADS)

    Hufnagel, Dirk

    2015-12-01

    In 2015, CMS will embark on a new era of collecting LHC collisions at unprecedented rates and complexity. This will put a tremendous stress on our computing systems. Prompt Processing of the raw data by the Tier-0 infrastructure will no longer be constrained to CERN alone due to the significantly increased resource requirements. In LHC Run 2, we will need to operate it as a distributed system utilizing both the CERN Cloud-based Agile Infrastructure and a significant fraction of the CMS Tier-1 Grid resources. In another big change for LHC Run 2, we will process all data using the multi-threaded framework to deal with the increased event complexity and to ensure efficient use of the resources. This contribution will cover the evolution of the Tier-0 infrastructure and present scale testing results and experiences from the first data taking in 2015.

  2. Analysis facility infrastructure (Tier-3) for ATLAS experiment

    NASA Astrophysics Data System (ADS)

    González de La Hoz, S.; March, L.; Ros, E.; Sánchez, J.; Amorós, G.; Fassi, F.; Fernández, A.; Kaci, M.; Lamas, A.; Salt, J.

    2008-04-01

    In the ATLAS computing model the tiered hierarchy ranged from the Tier-0 (CERN) down to desktops or workstations (Tier-3). The focus on defining the roles of each tiered component has evolved with the initial emphasis on the Tier-0 and Tier-1 definition and roles. The various LHC (Large Hadron Collider) projects, including ATLAS, then evolved the tiered hierarchy to include Tier-2’s (Regional centers) as part of their projects. Tier-3 centres, on the other hand, have been defined as whatever an institution could construct to support their Physics goals using institutional and otherwise leveraged resources and therefore have not been considered to be part of the official ATLAS computing resources. However, Tier-3 centres are going to exist and will have implications on how the computing model should support ATLAS physicists. Tier-3 users will want to access LHC data and simulations and will want to enable their resources to support their analysis and simulation work. This document will define how IFIC (Instituto de Física Corpuscular de Valencia), after discussing with the ATLAS Tier-3 task force, should interact with the ATLAS computing model, detail the conditions under which Tier-3 centres can expect some level of support and set reasonable expectations for the scope and support of ATLAS Tier-3 sites.

  3. Development and Application of a Two-Tier Diagnostic Test Measuring College Biology Students' Understanding of Diffusion and Osmosis after a Course of Instruction.

    ERIC Educational Resources Information Center

    Odom, Arthur Louis; Barrow, Lloyd H.

    1995-01-01

    Presents a diagnostic test for measuring college biology students' understanding of diffusion. Three general steps were used: (1) defining the content boundaries; (2) collecting information on students' misconceptions; and (3) instrument development. The split half reliability was 0.74, difficulty indices ranged from 0.23 to 0.95, and the…

  4. A Grant Project to Initiate School Counselors' Development of a Multi-Tiered System of Supports Based on Social-Emotional Data

    ERIC Educational Resources Information Center

    Harrington, Karen; Griffith, Catherine; Gray, Katharine; Greenspan, Scott

    2016-01-01

    This article provides an overview of a grant project designed to create a district-wide elementary school counseling program with a strong data-based decision-making process. Project goals included building data literacy skills among school counselors and developing the infrastructure to efficiently collect important social-emotional indicators…

  5. General Chemistry Students' Understanding of the Chemistry Underlying Climate Science and the Development of a Two-Tiered Multiple-Choice Diagnostic Instrument

    NASA Astrophysics Data System (ADS)

    Versprille, A.; Towns, M.; Mahaffy, P.; Martin, B.; McKenzie, L.; Kirchhoff, M.

    2013-12-01

    As part of the NSF funded Visualizing the Chemistry of Climate Change (VC3) project, we have developed a chemistry of climate science diagnostic instrument for use in general chemistry courses based on twenty-four student interviews. We have based our interview protocol on misconceptions identified in the research literature and the essential principles of climate change outlined in the CCSP document that pertain to chemistry (CCSP, 2009). The undergraduate student interviews elicited their understanding of the greenhouse effect, global warming, climate change, greenhouse gases, climate, and weather, and the findings from these interviews informed and guided the development of the multiple-choice diagnostic instrument. Our analysis and findings from the interviews indicate that students seem to confuse the greenhouse effect, global warming, and the ozone layer and in terms of chemistry concepts, the students lack a particulate level understanding of greenhouse gases causing them to not fully conceptualize the greenhouse effect and climate change. Details of the findings from the interviews, development of diagnostic instrument, and preliminary findings from the full implementation of the diagnostic instrument will be shared.

  6. A tiered approach for assessing children's exposure.

    PubMed Central

    Armstrong, T W; Hushka, L J; Tell, J G; Zaleski, R T

    2000-01-01

    Recently, intense attention has been given to children's health issues, particularly in the use of consumer products. Because of this attention, researchers have been planning and initiating studies specifically aimed at developing both toxicology data and exposure data directed to improve our understanding of industrial and consumer product chemical impacts on children's health. To ensure that this research is focused on the highest priority chemicals, we present a methodology for determining and prioritizing the higher hazard chemicals and scenarios for which children could be disproportionately or highly exposed. This tiered approach includes a screening step for initial chemical selection, a hazard assessment based on no- or lowest-observed-adverse-effect levels, and a margin of exposure (MOE) calculation. The initial chemical screen focuses on the chemical presence in specific media that are special to children, such as foods children regularly eat and drink, residential or school air, products children use, and soil and dust in and around residences. Data from the literature or from models serve as the initial exposure estimate. This methodology would allow us to focus on those chemicals to which children are most exposed that are also associated with, potentially, the highest risk. Use of the MOE calculation allows for comparison among chemicals, prioritization of chemicals for evaluation and testing, and identification of significant data gaps. PMID:10856018

  7. A tiered system for assessing the risk of genetically modified plants to non-target organisms.

    PubMed

    Garcia-Alonso, Monica; Jacobs, Erik; Raybould, Alan; Nickson, Thomas E; Sowig, Peter; Willekens, Hilde; Van der Kouwe, Pier; Layton, Raymond; Amijee, Firoz; Fuentes, Angel M; Tencalla, Francesca

    2006-01-01

    Representatives of the developers of modern agricultural biotechnology are proposing a tiered approach for conducting non-target organism risk assessment for genetically modified (GM) plants in Europe. The approach was developed by the Technical Advisory Group of the EuropaBio Plant Biotechnology Unit (http://www.europabio.org/TAG.htm) and complements other international activities to harmonize risk assessment. In the European Union (EU), the principles and methods to be followed in an environmental risk assessment for the placing on the market of GM plants are laid out in Annex II of Directive 2001/18/EC on the deliberate release into the environment of GMOs, Commission Decision 2002/623/EC and Regulation (EC) No. 1829/2003. Additional information is provided in the European Food Safety Authority guidance document of 2004. However, risk assessment for effects to non-target organisms could benefit from further clarification and remains the subject of much discussion in Europe. The industry-wide approach developed by EuropaBio is based on the fundamental steps of risk evaluation, namely hazard and exposure assessment. It follows a structured scheme including assessment planning, product characterization and assessment of hazard/exposure (Tier 0), single high dose and dose response testing (Tier 1), refined hazard characterization and exposure assessment (Tier 2) and further refined risk assessment experiments (Tier 3). An additional tier (Tier 4) was included to reflect the fact that post-market activities such as monitoring are required under Directive 2001/18/EC. The approach is compatible with conditions of commercial release in the EU and around the world.

  8. Research Methodology on Language Development from a Complex Systems Perspective

    ERIC Educational Resources Information Center

    Larsen-Freeman, Diane; Cameron, Lynne

    2008-01-01

    Changes to research methodology motivated by the adoption of a complexity theory perspective on language development are considered. The dynamic, nonlinear, and open nature of complex systems, together with their tendency toward self-organization and interaction across levels and timescales, requires changes in traditional views of the functions…

  9. Application of Complex Systems Research To Efforts of International Development

    NASA Astrophysics Data System (ADS)

    Brunner, Hans-Peter

    Fundamental research on complex systems has shown relevance to efforts of international development. This paper canvasses some practitioner friendly approaches to international development. Development is about interventions in a highly complex system, the society. Complex systems research tells us that development interventions should not be overly planned, rather the fundamental uncertainty of a changing social system requires a diversity of interventions, and rapid learning from development success and failure. Developing economies are functioning at a low level of effectiveness and resource use. Complex systems are change resistant, and intervention requires understanding the autocatalytic nature of a process of change. International development is about the stimulation of a society's innate autocatalytic / self-organizing processes through interventions that stimulate enough to overcome change resistance, but which do not overwhelm the system. Since the size of financial interventions may in some cases be a substantial fraction of the existing economic activity, disruption is a likely outcome. Crucially, one must avoid having the socio-economic activity organized around the intervention itself, since then an undesirable dependency of the economy on the intervention arises. Stimulation of the innate modes of activity results in the development of socio-economic organization around energy, material and financial flows. The primary generator of effectiveness is an appropriate network structure of interactions and relationships. This paper summarizes traditional development efforts and their outcomes as well as a plausible description of the process of complex systems motivated interventions. Examples are given of recent approaches which aim to appropriately stimulate international development.

  10. SWPBIS Tiered Fidelity Inventory. Version 2.1

    ERIC Educational Resources Information Center

    Algozzine, B.; Barrett, S.; Eber, L.; George, H.; Horner, R.; Lewis, T.; Putnam, B.; Swain-Bradway, J.; McIntosh, K.; Sugai, G.

    2014-01-01

    The purpose of the SWPBIS Tiered Fidelity Inventory (TFI) is to provide a valid, reliable, and efficient measure of the extent to which school personnel are applying the core features of school-wide positive behavioral interventions and supports (SWPBIS). The TFI is divided into three sections (Tier I: Universal SWPBIS Features; Tier II: Targeted…

  11. 26 CFR 1.1446-5 - Tiered partnership structures.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 12 2013-04-01 2013-04-01 false Tiered partnership structures. 1.1446-5 Section... Corporations and Tax-Free Covenant Bonds § 1.1446-5 Tiered partnership structures. (a) In general. The rules of... section prescribes rules applicable to a publicly traded partnership in a tiered partnership...

  12. 26 CFR 1.1446-5 - Tiered partnership structures.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 12 2012-04-01 2012-04-01 false Tiered partnership structures. 1.1446-5 Section... Corporations and Tax-Free Covenant Bonds § 1.1446-5 Tiered partnership structures. (a) In general. The rules of... section prescribes rules applicable to a publicly traded partnership in a tiered partnership...

  13. 26 CFR 1.1446-5 - Tiered partnership structures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 12 2011-04-01 2011-04-01 false Tiered partnership structures. 1.1446-5 Section... Corporations and Tax-Free Covenant Bonds § 1.1446-5 Tiered partnership structures. (a) In general. The rules of... section prescribes rules applicable to a publicly traded partnership in a tiered partnership...

  14. 26 CFR 1.1446-5 - Tiered partnership structures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 12 2010-04-01 2010-04-01 false Tiered partnership structures. 1.1446-5 Section...-Free Covenant Bonds § 1.1446-5 Tiered partnership structures. (a) In general. The rules of this section... prescribes rules applicable to a publicly traded partnership in a tiered partnership structure. Paragraph...

  15. 20 CFR 226.11 - Employee tier II.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Employee tier II. 226.11 Section 226.11... EMPLOYEE, SPOUSE, AND DIVORCED SPOUSE ANNUITIES Computing an Employee Annuity § 226.11 Employee tier II... September 1981, the tier II benefit is computed as follows: (a) The product obtained by multiplying...

  16. Breaks Are Better: A Tier II Social Behavior Intervention

    ERIC Educational Resources Information Center

    Boyd, R. Justin; Anderson, Cynthia M.

    2013-01-01

    Multi-tiered systems of social behavioral support in schools provide varying levels of intervention matched to student need. Tier I (primary or universal) systems are for all students and are designed to promote pro-social behavior. Tier III (tertiary or intensive) supports are for students who engage in serious challenging behavior that has not…

  17. 76 FR 71623 - Publication of the Tier 2 Tax Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... Internal Revenue Service Publication of the Tier 2 Tax Rates AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice. SUMMARY: Publication of the tier 2 tax rates for calendar year 2012 as required by section 3241(d) of the Internal Revenue Code (26 U.S.C. section 3241). Tier 2 taxes on...

  18. 78 FR 71039 - Publication of the Tier 2 Tax Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... Internal Revenue Service Publication of the Tier 2 Tax Rates AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice. SUMMARY: Publication of the tier 2 tax rates for calendar year 2014 as required by section 3241(d) of the Internal Revenue Code (26 U.S.C. section 3241). Tier 2 taxes on...

  19. 77 FR 71481 - Publication of the Tier 2 Tax Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ... Internal Revenue Service Publication of the Tier 2 Tax Rates AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice. ] SUMMARY: Publication of the tier 2 tax rates for calendar year 2013 as required by section 3241(d) of the Internal Revenue Code (26 U.S.C. 3241). Tier 2 taxes on railroad...

  20. 75 FR 73166 - Publication of the Tier 2 Tax Rates

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-29

    ... Internal Revenue Service Publication of the Tier 2 Tax Rates AGENCY: Internal Revenue Service, Treasury. ACTION: Notice. SUMMARY: Publication of the tier 2 tax rates for calendar year 2011 as required by section 3241(d) of the Internal Revenue Code (26 U.S.C. section 3241). Tier 2 taxes on railroad...

  1. 40 CFR 79.53 - Tier 2.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... comparable to that provided by such testing. (3) The test animals shall be rodents, preferably a strain of... FUELS AND FUEL ADDITIVES Testing Requirements for Registration § 79.53 Tier 2. (a) Generally. Subject to... subject to testing under this subpart must be tested in accordance with each of the testing guidelines...

  2. Revitalizing Tier 2 Intervention with Graphic Novels

    ERIC Educational Resources Information Center

    Smetana, Linda; Grisham, Dana L.

    2012-01-01

    The authors explore the practice of incorporating graphic novels in a Tier 2 Response To Intervention (RTI) program for five elementary-aged struggling readers in an urban school. Using a formative experiment framework, the study found that graphic novels provided a vehicle for the application of word recognition and fluency strategies learned in…

  3. 18 CFR 707.9 - Tiering.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... recommended format (40 CFR 1502.10) on the basis of water and related land resources of an entire region or... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Tiering. 707.9 Section 707.9 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COMPLIANCE WITH THE...

  4. 18 CFR 707.9 - Tiering.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... recommended format (40 CFR 1502.10) on the basis of water and related land resources of an entire region or... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Tiering. 707.9 Section 707.9 Conservation of Power and Water Resources WATER RESOURCES COUNCIL COMPLIANCE WITH THE...

  5. A Three-Tier Diagnostic Test to Assess Pre-Service Teachers' Misconceptions about Global Warming, Greenhouse Effect, Ozone Layer Depletion, and Acid Rain

    ERIC Educational Resources Information Center

    Arslan, Harika Ozge; Cigdemoglu, Ceyhan; Moseley, Christine

    2012-01-01

    This study describes the development and validation of a three-tier multiple-choice diagnostic test, the atmosphere-related environmental problems diagnostic test (AREPDiT), to reveal common misconceptions of global warming (GW), greenhouse effect (GE), ozone layer depletion (OLD), and acid rain (AR). The development of a two-tier diagnostic test…

  6. Tier 1 ecological evaluation of proposed discharge of dredged material from Oakland Harbor into ocean waters

    SciTech Connect

    Shreffler, D.K.; Thorn, R.M.; Walls, B.E.; Word, J.Q.

    1994-01-01

    The Water Resources Development Act of 1986 (Public Law 99--662) authorized the U.S. Army Corps of Engineers (USACE) -- San Francisco District, to accommodate larger, deeper draft vessels in Oakland inner and Outer Harbors by deepening and widening the existing navigation channel, and providing turning basins and maneuvering areas in Oakland inner Harbor. The suitability of the resulting dredged material for disposal into ocean waters was subject to the procedures of the 1991 Testing Manual, Evaluation of Dredged Material Proposed for Ocean Disposal, known as the ``Green Book``. The Green Book provides a tiered approach for testing the suitability of dredged materials through chemical, physical, and biological evaluations. The first level of investigation, or Tier 1 evaluation, is used to determine whether a decision on LPC compliance can be made on the basis of readily available information. The Tier 1 report primarily summarizes existing information on sediment contamination and toxicity potential, identifies contaminants of concern, and determines the need for further testing. To assist the USACE in determining the suitability of dredged material from Oakland inner and Outer Harbors for ocean disposal, Battelle/Marine Sciences Laboratory prepared this Tier 1 report based upon information and data provided by USACE. Because this Tier 1 report originated well after an LPC determination was made to require testing of project sediments in Tier 3, the primary purpose of this report was to identify contaminants of concern (if any) in that particular dredged material. In addition, this Tier 1 report summarizes available information on chemical, physical, and biological characterization of the sediments in Oakland inner and Outer Harbors.

  7. Large scale commissioning and operational experience with tier-2 to tier-2 data transfer links in CMS

    NASA Astrophysics Data System (ADS)

    Letts, J.; Magini, N.

    2011-12-01

    Tier-2 to Tier-2 data transfers have been identified as a necessary extension of the CMS computing model. The Debugging Data Transfers (DDT) Task Force in CMS was charged with commissioning Tier-2 to Tier-2 PhEDEx transfer links beginning in late 2009, originally to serve the needs of physics analysis groups for the transfer of their results between the storage elements of the Tier-2 sites associated with the groups. PhEDEx is the data transfer middleware of the CMS experiment. For analysis jobs using CRAB, the CMS Remote Analysis Builder, the challenges of remote stage out of job output at the end of the analysis jobs led to the introduction of a local fallback stage out, and will eventually require the asynchronous transfer of user data over essentially all of the Tier-2 to Tier-2 network using the same PhEDEx infrastructure. In addition, direct file sharing of physics and Monte Carlo simulated data between Tier-2 sites can relieve the operational load of the Tier-1 sites in the original CMS Computing Model, and already represents an important component of CMS PhEDEx data transfer volume. The experience, challenges and methods used to debug and commission the thousands of data transfers links between CMS Tier-2 sites world-wide are explained and summarized. The resulting operational experience with Tier-2 to Tier-2 transfers is also presented.

  8. A four-tier problem-solving scaffold to teach pain management in dental school.

    PubMed

    Ivanoff, Chris S; Hottel, Timothy L

    2013-06-01

    Pain constitutes a major reason patients pursue dental treatment. This article presents a novel curriculum to provide dental students comprehensive training in the management of pain. The curriculum's four-tier scaffold combines traditional and problem-based learning to improve students' diagnostic, pharmacotherapeutic, and assessment skills to optimize decision making when treating pain. Tier 1 provides underpinning knowledge of pain mechanisms with traditional and contextualized instruction by integrating clinical correlations and studying worked cases that stimulate clinical thinking. Tier 2 develops critical decision making skills through self-directed learning and actively solving problem-based cases. Tier 3 exposes students to management approaches taken in allied health fields and cultivates interdisciplinary communication skills. Tier 4 provides a "knowledge and experience synthesis" by rotating students through community pain clinics to practice their assessment skills. This combined teaching approach aims to increase critical thinking and problem-solving skills to assist dental graduates in better management of pain throughout their careers. Dental curricula that have moved to comprehensive care/private practice models are well-suited for this educational approach. The goal of this article is to encourage dental schools to integrate pain management into their curricula, to develop pain management curriculum resources for dental students, and to provide leadership for change in pain management education.

  9. The Impact of Tiered Physician Networks on Patient Choices

    PubMed Central

    Sinaiko, Anna D; Rosenthal, Meredith B

    2014-01-01

    Objective To assess whether patient choice of physician or health plan was affected by physician tier-rankings. Data Sources Administrative claims and enrollment data on 171,581 nonelderly beneficiaries enrolled in Massachusetts Group Insurance Commission health plans that include a tiered physician network and who had an office visit with a tiered physician. Study Design We estimate the impact of tier-rankings on physician market share within a plan of new patients and on the percent of a physician's patients who switch to other physicians with fixed effects regression models. The effect of tiering on consumer plan choice is estimated using logistic regression and a pre–post study design. Principal Findings Physicians in the bottom (least-preferred) tier, particularly certain specialist physicians, had lower market share of new patient visits than physicians with higher tier-rankings. Patients whose physician was in the bottom tier were more likely to switch health plans. There was no effect of tier-ranking on patients switching away from physicians whom they have seen previously. Conclusions The effect of tiering appears to be among patients who choose new physicians and at the lower end of the distribution of tiered physicians, rather than moving patients to the “best” performers. These findings suggest strong loyalty of patients to physicians more likely to be considered their personal doctor. PMID:24611599

  10. Tiered screening and testing strategy for xenoestrogens and antiandrogens.

    PubMed

    Gray, L E

    1998-12-28

    Anthropogenic chemicals that disrupt endocrine function during critical stages of development can produce profound reproductive alterations in both wildlife and humans. Of the tens of thousands of chemicals in existence, few have been tested for their ability to disrupt the endocrine system. Newly enacted legislation requires that the USEPA develop a chemical screening and testing program for endocrine effects. At present, the Endocrine Disrupters Screening and Testing Advisory Committee (EDSTAC) is considering a screening battery (Tier 1) to detect (anti)estrogenic (E) (anti)androgenic (A) and antithyroid activities using in vivo and in vitro assays. In addition, the battery should detect alterations of hypothalamic-pituitary function, steroid/thyroid hormone synthesis as well as receptor-mediated effects in mammals and other taxa. Chemicals positive in Tier 1 should be labeled as potential endocrine disrupters and subjected to testing (Tier 2). The present discussion will provide examples of in vitro (receptor binding, gene expression and steroidogenesis) and in vivo assays for screening. Short-term in vivo assays which have been used to detect estrogenicity for over 70 years are still useful in this regard. Identification of (anti)androgenic activity is easily accomplished by examination of growth of androgen-dependent tissues in young castrated male rats, determination of the age at puberty (balanopreputial separation) or by examination of reproductive malformations after in utero exposure (hypospadias, testicular non-descent, retained nipples, a vaginal pouch, prostate agenesis, and reduced anogenital distance). Pubertal assays with intact animals will not only detect chemicals that alter E-A function via their nuclear receptors, but also will detect altered hormone synthesis and alterations of the hypothalamic-pituitary-gonadal axis. While in utero assays are critical for testing, presently they are not included in screening because they can be relatively

  11. Can recent pan-tropical biomass maps be used to derive alternative Tier 1 values for reporting REDD+ activities under UNFCCC?

    NASA Astrophysics Data System (ADS)

    Langner, Andreas; Achard, Frédéric; Grassi, Giacomo

    2014-12-01

    The IPCC Guidelines propose 3 Tier levels for greenhouse gas monitoring within the forest land category with a hierarchical order in terms of accuracy, data requirements and complexity. Due to missing data and/or capacities, many developing countries, potentially interested in the reducing emissions from deforestation and forest degradation scheme, have to rely on Tier 1 default values with highest uncertainties. A possible way to increase the credibility of uncertain estimates is to apply a conservative approach, for which standard statistical information is needed. However, such information is currently not available for the IPCC values. In our study we combine a recent global forest mask, an ecological zoning map and the pan-tropical AGB datasets of Saatchi and Baccini to derive mean forest AGB values per ecological zone and continent as well as their corresponding confidence intervals. Such analysis can be considered transparent as the datasets/methodologies are well documented. Our study leads to alternative Tier 1 values and allows the application of statistically-based conservative approaches. Our AGB estimates derived from Saatchi and Baccini datasets are 35% and 24% lower respectively than the IPCC values. When restricting the analysis to intact forest landscapes resulting ABG estimates derived from Saatchi and Baccini datasets get closer to the IPCC values with 13% and 1% differences respectively (underestimation). This suggests that the IPCC default values are mainly based on plots in mature forest stands. However, as tropical forests generally consist of a mixture of intact and degraded stands, the use of IPCC values may not properly reflect the reality. Finally, we propose to use the average composite of the Saatchi and Baccini datasets to produce improved alternative IPCC Tier 1 values. The values derived from such approach can easily be updated when newer and/or improved pan-tropical AGB maps will be available.

  12. Tiered Internship Model for Undergraduate Students in Geospatial Science and Technology

    ERIC Educational Resources Information Center

    Kopteva, Irina A.; Arkowski, Donna; Craft, Elaine L.

    2015-01-01

    This article discusses the development, implementation, and evaluation of a tiered internship program for undergraduate students in geospatial science and technology (TIMSGeoTech). The internship program assists education programs in providing skill development that is relevant and useful, and it aligns graduates and their skills with industry…

  13. Supporting Comprehensive, Integrated, Three-Tiered Models of Prevention in Schools: Administrators' Perspectives

    ERIC Educational Resources Information Center

    Lane, Kathleen Lynne; Carter, Erik W.; Jenkins, Abbie; Dwiggins, Lauren; Germer, Kathryn

    2015-01-01

    We report findings from a statewide survey of 365 site-level administrators developed to (a) learn about the extent to which schools across the state were implementing components of multi-tiered systems of support and (b) determine the areas in which these schools might need professional development or resources to support them. At least half of…

  14. A tiered assessment framework to evaluate human health risk of contaminated sediment.

    PubMed

    Greenfield, Ben K; Melwani, Aroon R; Bay, Steven M

    2015-07-01

    For sediment contaminated with bioaccumulative pollutants (e.g., PCBs and organochorine pesticides), human consumption of seafood that contain bioaccumulated sediment-derived contaminants is a well-established exposure pathway. Historically, regulation and management of this bioaccumulation pathway has focused on site-specific risk assessment. The state of California (United States) is supporting the development of a consistent and quantitative sediment assessment framework to aid in interpreting a narrative objective to protect human health. The conceptual basis of this framework focuses on 2 key questions: 1) do observed pollutant concentrations in seafood from a given site pose unacceptable health risks to human consumers? and 2) is sediment contamination at a site a significant contributor to seafood contamination? The first question is evaluated by interpreting seafood tissue concentrations at the site, based on health risk calculations. The second question is evaluated by interpreting site-specific sediment chemistry data using a food web bioaccumulation model. The assessment framework includes 3 tiers (screening assessment, site assessment, and refined site assessment), which enables the assessment to match variations in data availability, site complexity, and study objectives. The second and third tiers use a stochastic simulation approach, incorporating information on variability and uncertainty of key parameters, such as seafood contaminant concentration and consumption rate by humans. The framework incorporates site-specific values for sensitive parameters and statewide values for difficult to obtain or less sensitive parameters. The proposed approach advances risk assessment policy by incorporating local data into a consistent region-wide problem formulation, applying best available science in a streamlined fashion. PMID:25641876

  15. A tiered assessment framework to evaluate human health risk of contaminated sediment.

    PubMed

    Greenfield, Ben K; Melwani, Aroon R; Bay, Steven M

    2015-07-01

    For sediment contaminated with bioaccumulative pollutants (e.g., PCBs and organochorine pesticides), human consumption of seafood that contain bioaccumulated sediment-derived contaminants is a well-established exposure pathway. Historically, regulation and management of this bioaccumulation pathway has focused on site-specific risk assessment. The state of California (United States) is supporting the development of a consistent and quantitative sediment assessment framework to aid in interpreting a narrative objective to protect human health. The conceptual basis of this framework focuses on 2 key questions: 1) do observed pollutant concentrations in seafood from a given site pose unacceptable health risks to human consumers? and 2) is sediment contamination at a site a significant contributor to seafood contamination? The first question is evaluated by interpreting seafood tissue concentrations at the site, based on health risk calculations. The second question is evaluated by interpreting site-specific sediment chemistry data using a food web bioaccumulation model. The assessment framework includes 3 tiers (screening assessment, site assessment, and refined site assessment), which enables the assessment to match variations in data availability, site complexity, and study objectives. The second and third tiers use a stochastic simulation approach, incorporating information on variability and uncertainty of key parameters, such as seafood contaminant concentration and consumption rate by humans. The framework incorporates site-specific values for sensitive parameters and statewide values for difficult to obtain or less sensitive parameters. The proposed approach advances risk assessment policy by incorporating local data into a consistent region-wide problem formulation, applying best available science in a streamlined fashion.

  16. Three Tier Unified Process Model for Requirement Negotiations and Stakeholder Collaborations

    NASA Astrophysics Data System (ADS)

    Niazi, Muhammad Ashraf Khan; Abbas, Muhammad; Shahzad, Muhammad

    2012-11-01

    This research paper is focused towards carrying out a pragmatic qualitative analysis of various models and approaches of requirements negotiations (a sub process of requirements management plan which is an output of scope managementís collect requirements process) and studies stakeholder collaborations methodologies (i.e. from within communication management knowledge area). Experiential analysis encompass two tiers; first tier refers to the weighted scoring model while second tier focuses on development of SWOT matrices on the basis of findings of weighted scoring model for selecting an appropriate requirements negotiation model. Finally the results are simulated with the help of statistical pie charts. On the basis of simulated results of prevalent models and approaches of negotiations, a unified approach for requirements negotiations and stakeholder collaborations is proposed where the collaboration methodologies are embeded into selected requirements negotiation model as internal parameters of the proposed process alongside some external required parameters like MBTI, opportunity analysis etc.

  17. Development and Application of Agglomerated Multigrid Methods for Complex Geometries

    NASA Technical Reports Server (NTRS)

    Nishikawa, Hiroaki; Diskin, Boris; Thomas, James L.

    2010-01-01

    We report progress in the development of agglomerated multigrid techniques for fully un- structured grids in three dimensions, building upon two previous studies focused on efficiently solving a model diffusion equation. We demonstrate a robust fully-coarsened agglomerated multigrid technique for 3D complex geometries, incorporating the following key developments: consistent and stable coarse-grid discretizations, a hierarchical agglomeration scheme, and line-agglomeration/relaxation using prismatic-cell discretizations in the highly-stretched grid regions. A signi cant speed-up in computer time is demonstrated for a model diffusion problem, the Euler equations, and the Reynolds-averaged Navier-Stokes equations for 3D realistic complex geometries.

  18. A three-tier framework for monitoring antiretroviral therapy in high HIV burden settings

    PubMed Central

    Osler, Meg; Hilderbrand, Katherine; Hennessey, Claudine; Arendse, Juanita; Goemaere, Eric; Ford, Nathan; Boulle, Andrew

    2014-01-01

    The provision of antiretroviral therapy (ART) in low and middle-income countries is a chronic disease intervention of unprecedented magnitude and is the dominant health systems challenge for high-burden countries, many of which rank among the poorest in the world. Substantial external investment, together with the requirement for service evolution to adapt to changing needs, including the constant shift to earlier ART initiation, makes outcome monitoring and reporting particularly important. However, there is growing concern at the inability of many high-burden countries to report on the outcomes of patients who have been in care for various durations, or even the number of patients in care at a particular point in time. In many instances, countries can only report on the number of patients ever started on ART. Despite paper register systems coming under increasing strain, the evolution from paper directly to complex electronic medical record solutions is not viable in many contexts. Implementing a bridging solution, such as a simple offline electronic version of the paper register, can be a pragmatic alternative. This paper describes and recommends a three-tiered monitoring approach in low- and middle-income countries based on the experience implementing such a system in the Western Cape province of South Africa. A three-tier approach allows Ministries of Health to strategically implement one of the tiers in each facility offering ART services. Each tier produces the same nationally required monthly enrolment and quarterly cohort reports so that outputs from the three tiers can be aggregated into a single database at any level of the health system. The choice of tier is based on context and resources at the time of implementation. As resources and infrastructure improve, more facilities will transition to the next highest and more technologically sophisticated tier. Implementing a three-tier monitoring system at country level for pre-antiretroviral wellness, ART

  19. Mediator Complex Dependent Regulation of Cardiac Development and Disease

    PubMed Central

    Grueter, Chad E.

    2013-01-01

    Cardiovascular disease (CVD) is a leading cause of morbidity and mortality. The risk factors for CVD include environmental and genetic components. Human mutations in genes involved in most aspects of cardiovascular function have been identified, many of which are involved in transcriptional regulation. The Mediator complex serves as a pivotal transcriptional regulator that functions to integrate diverse cellular signals by multiple mechanisms including recruiting RNA polymerase II, chromatin modifying proteins and non-coding RNAs to promoters in a context dependent manner. This review discusses components of the Mediator complex and the contribution of the Mediator complex to normal and pathological cardiac development and function. Enhanced understanding of the role of this core transcriptional regulatory complex in the heart will help us gain further insights into CVD. PMID:23727265

  20. Development of Onboard Computer Complex for Russian Segment of ISS

    NASA Technical Reports Server (NTRS)

    Branets, V.; Brand, G.; Vlasov, R.; Graf, I.; Clubb, J.; Mikrin, E.; Samitov, R.

    1998-01-01

    Report present a description of the Onboard Computer Complex (CC) that was developed during the period of 1994-1998 for the Russian Segment of ISS. The system was developed in co-operation with NASA and ESA. ESA developed a new computation system under the RSC Energia Technical Assignment, called DMS-R. The CC also includes elements developed by Russian experts and organizations. A general architecture of the computer system and the characteristics of primary elements of this system are described. The system was integrated at RSC Energia with the participation of American and European specialists. The report contains information on software simulators, verification and de-bugging facilities witch were been developed for both stand-alone and integrated tests and verification. This CC serves as the basis for the Russian Segment Onboard Control Complex on ISS.

  1. Development of the follicle complex and oocyte staging in red drum, Sciaenops ocellatus Linnaeus, 1776 (Perciformes, Sciaenidae).

    PubMed

    Grier, Harry J

    2012-08-01

    Pelagic egg development in red drum, Sciaenops ocellatus, is described using tiered staging. Based on mitosis and meiosis, there are five periods: Mitosis of Oogonia, Active Meiosis I, Arrested Meiosis I, Active Meiosis II, and Arrested Meiosis II. The Periods are divided into six stages: Mitotic Division of Oogonia, Chromatin Nucleolus, Primary Growth, Secondary Growth, Oocyte Maturation and Ovulation. The Chromatin Nucleolus Stage is divided into four steps: Leptotene, Zygotene, Pachytene, and Early Diplotene. Oocytes in the last step possess one nucleolus, dispersed chromatin with forming lampbrush chromosomes and lack basophilic ooplasm. The Primary Growth Stage, characterized by basophilic ooplasm and absence of yolk in oocytes, is divided into five steps: One-Nucleolus, Multiple Nucleoli, Perinucleolar, Oil Droplets, and Cortical Alveolar. During primary growth, the Balbiani body develops from nuage, enlarges and disperses throughout the ooplasm as both endoplasmic reticulum and Golgi develop within it. Secondary growth or vitellogenesis has three steps: Early Secondary Growth, Late Secondary Growth and Full-Grown. The Oocyte Maturation Stage, including ooplasmic and germinal vesicle maturation, has four steps: Eccentric Germinal Vesicle, Germinal Vesicle Migration, Germinal Vesicle Breakdown and Resumption of Meiosis when complete yolk hydration occurs. The period is Arrested Meiosis II. When folliculogenesis is completed, the ovarian follicle, an oocyte and encompassing follicle cells, is surrounded by a basement membrane and developing theca, all forming a follicle complex. After ovulation, a newly defined postovulatory follicle complex remains attached to the germinal epithelium. It is composed of a basement membrane that separates the postovulatory follicle from the postovulatory theca. Arrested Meiosis I encompasses primary and secondary growth (vitellogenesis) and includes most of oocyte maturation until the resumption of meiosis (Active Meiosis II

  2. Developing Students' Understanding of Complex Systems in the Geosciences (Invited)

    NASA Astrophysics Data System (ADS)

    Manduca, C. A.; Mogk, D. W.; Bice, D. M.; Pyle, E.; Slotta, J.

    2010-12-01

    Developing a systems perspective is a commonly cited goal for geosciences courses and programs. This perspective is a powerful tool for critical thinking, problem solving and integrative thinking across and beyond the sciences. In April 2010, a NSF funded ‘On the Cutting Edge’ workshop brought together 45 geoscience faculty, education and cognitive science researchers, and faculty from other STEM and social science disciplines that make use of a complex systems approach. The workshop participants focused on understanding the challenges inherent in developing an understanding of complex systems and the teaching strategies currently in use across the disciplines. These include using models and visualizations to allow students to experiment with complex systems, using projects and problems to give students experience with data and observations derived from a complex system, and using illustrated lectures and discussions and analogies to illuminate the salient aspects of complex systems. The workshop website contains a collection of teaching activities, instructional resources and courses that demonstrate these approaches. The workshop participants concluded that research leading to a clear articulation of what constitutes understanding complex system behavior is needed, as are instruments and performance measures that could be used to assess this understanding. Developing the ability to recognize complex systems and understand their behavior is a significant learning task that cannot be achieved in a single course. Rather it is a type of literacy that should be taught in a progression extending from elementary school to college and across the disciplines. Research defining this progression and its endpoints is needed. Full information about the workshop, its discussions, and resulting collections of courses, activities, references and ideas are available on the workshop website.

  3. WHALE, a management tool for Tier-2 LCG sites

    NASA Astrophysics Data System (ADS)

    Barone, L. M.; Organtini, G.; Talamo, I. G.

    2012-12-01

    The LCG (Worldwide LHC Computing Grid) is a grid-based hierarchical computing distributed facility, composed of more than 140 computing centers, organized in 4 tiers, by size and offer of services. Every site, although indipendent for many technical choices, has to provide services with a well-defined set of interfaces. For this reason, different LCG sites need frequently to manage very similar situations, like jobs behaviour on the batch system, dataset transfers between sites, operating system and experiment software installation and configuration, monitoring of services. In this context we created WHALE (WHALE Handles Administration in an LCG Environment), a software actually used at the T2_IT_Rome site, an LCG Tier-2 for the CMS experiment. WHALE is a generic, site independent tool written in Python: it allows administrator to interact in a uniform and coherent way with several subsystems using a high level syntax which hides specific commands. The architecture of WHALE is based on the plugin concept and on the possibility of connecting the output of a plugin to the input of the next one, in a pipe-like system, giving the administrator the possibility of making complex functions by combining the simpler ones. The core of WHALE just handles the plugin orchestrations, while even the basic functions (eg. the WHALE activity logging) are performed by plugins, giving the capability to tune and possibly modify every component of the system. WHALE already provides many plugins useful for a LCG site and some more for a Tier-2 of the CMS experiment, especially in the field of job management, dataset transfer and analysis of performance results and availability tests (eg. Nagios tests, SAM tests). Thanks to its architecture and the provided plugins WHALE makes easy to perform tasks that, even if logically simple, are technically complex or tedious, like eg. closing all the worker nodes with a job-failure rate greater than a given threshold. Finally, thanks to the

  4. Development of Three-Dimensional Completion of Complex Objects

    ERIC Educational Resources Information Center

    Soska, Kasey C.; Johnson, Scott P.

    2013-01-01

    Three-dimensional (3D) object completion, the ability to perceive the backs of objects seen from a single viewpoint, emerges at around 6 months of age. Yet, only relatively simple 3D objects have been used in assessing its development. This study examined infants' 3D object completion when presented with more complex stimuli. Infants…

  5. Deictic Relational Complexity and the Development of Deception

    ERIC Educational Resources Information Center

    McHugh, Louise; Barnes-Holmes, Yvonne; Barnes-Holmes, Dermot; Stewart, Ian; Dymond, Simon

    2007-01-01

    An empirical investigation of age-related development of the ability to deceive was conducted from the perspective of Relational Frame Theory, which, unlike the traditional approach, Theory of Mind, has been used to analyze deception in terms of the complexity of the relational responding involved. A derived relational responding-based protocol…

  6. Environmental Complexity and Central Nervous System Development and Function

    ERIC Educational Resources Information Center

    Lewis, Mark H.

    2004-01-01

    Environmental restriction or deprivation early in development can induce social, cognitive, affective, and motor abnormalities similar to those associated with autism. Conversely, rearing animals in larger, more complex environments results in enhanced brain structure and function, including increased brain weight, dendritic branching,…

  7. Tier 3- DarkStar on ramp from above

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The Lockheed Martin/Boeing Tier III- (minus) unpiloted aerial vehicle is inspected by NASA personnel September 14, 1995, following its arrival at the Dryden Flight Research Center, Edwards, California. The Tier III Minus project used Dryden ground facilities during the flight test program. The vehicle was developed by Lockheed Martin Skunk Works and Boeing Defense and Space Group to satisfy a goal of the Defense Airborne Reconnaissance Office to supply responsive and sustained data from anywhere within enemy territory, day or night, in all types of weather. Dubbed DarkStar, the vehicle, with a wing span of 69 feet, was designed to fly above 45,000 feet at subsonic speeds on missions lasting more than eight hours. The first DarkStar prototype (article #695) made its first flight on March 29, 1996. At the begininning of its second flight, on April 22, 1996, it crashed on takeoff, and was destroyed. The second Darkstar prototype (article #696) made five flights between June 29, 1998 and January 9, 1999. The program was cancelled on January 28, 1999.

  8. Tier 3- DarkStar engine run on ramp

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The Lockheed Martin/Boeing Tier III- (minus) unpiloted aerial vehicle undergoing an engine run on the ramp at, following its arrival at the Dryden Flight Research Center, Edwards, California. The Tier III Minus project used Dryden ground facilities during the flight test program. The vehicle was developed by Lockheed Martin Skunk Works and Boeing Defense and Space Group to satisfy a goal of the Defense Airborne Reconnaissance Office to supply responsive and sustained data from anywhere within enemy territory, day or night, in all types of weather. Dubbed DarkStar, the vehicle, with a wing span of 69 feet, was designed to fly above 45,000 feet at subsonic speeds on missions lasting more than eight hours. The first DarkStar prototype (article #695) made its first flight on March 29, 1996. At the begininning of its second flight, on April 22, 1996, it crashed on takeoff, and was destroyed. More than two years passed before the second Darkstar prototype (article #696) took to the air on June 29, 1998. The vehicle made a total of five flights, the last on January 9, 1999. The program was cancelled on January 28, 1999.

  9. Benchmarking of Decision-Support Tools Used for Tiered Sustainable Remediation Appraisal.

    PubMed

    Smith, Jonathan W N; Kerrison, Gavin

    2013-01-01

    Sustainable remediation comprises soil and groundwater risk-management actions that are selected, designed, and operated to maximize net environmental, social, and economic benefit (while assuring protection of human health and safety). This paper describes a benchmarking exercise to comparatively assess potential differences in environmental management decision making resulting from application of different sustainability appraisal tools ranging from simple (qualitative) to more quantitative (multi-criteria and fully monetized cost-benefit analysis), as outlined in the SuRF-UK framework. The appraisal tools were used to rank remedial options for risk management of a subsurface petroleum release that occurred at a petrol filling station in central England. The remediation options were benchmarked using a consistent set of soil and groundwater data for each tier of sustainability appraisal. The ranking of remedial options was very similar in all three tiers, and an environmental management decision to select the most sustainable options at tier 1 would have been the same decision at tiers 2 and 3. The exercise showed that, for relatively simple remediation projects, a simple sustainability appraisal led to the same remediation option selection as more complex appraisal, and can be used to reliably inform environmental management decisions on other relatively simple land contamination projects.

  10. Regulation of flower development in Arabidopsis by SCF complexes.

    PubMed

    Ni, Weimin; Xie, Daoxin; Hobbie, Lawrence; Feng, Baomin; Zhao, Dazhong; Akkara, Joseph; Ma, Hong

    2004-04-01

    SCF complexes are the largest and best studied family of E3 ubiquitin protein ligases that facilitate the ubiquitylation of proteins targeted for degradation. The SCF core components Skp1, Cul1, and Rbx1 serve in multiple SCF complexes involving different substrate-specific F-box proteins that are involved in diverse processes including cell cycle and development. In Arabidopsis, mutations in the F-box gene UNUSUAL FLORAL ORGANS (UFO) result in a number of defects in flower development. However, functions of the core components Cul1 and Rbx1 in flower development are poorly understood. In this study we analyzed floral phenotypes caused by altering function of Cul1 or Rbx1, as well as the effects of mutations in ASK1 and ASK2. Plants homozygous for a point mutation in the AtCUL1 gene showed reduced floral organ number and several defects in each of the four whorls. Similarly, plants with reduced AtRbx1 expression due to RNA interference also exhibited floral morphological defects. In addition, compared to the ask1 mutant, plants homozygous for ask1 and heterozygous for ask2 displayed enhanced reduction of B function, as well as other novel defects of flower development, including carpelloid sepals and an inhibition of petal development. Genetic analyses demonstrate that AGAMOUS (AG) is required for the novel phenotypes observed in the first and second whorls. Furthermore, the genetic interaction between UFO and AtCUL1 supports the idea that UFO regulates multiple aspects of flower development as a part of SCF complexes. These results suggest that SCF complexes regulate several aspects of floral development in Arabidopsis. PMID:15047903

  11. Regulation of flower development in Arabidopsis by SCF complexes.

    PubMed

    Ni, Weimin; Xie, Daoxin; Hobbie, Lawrence; Feng, Baomin; Zhao, Dazhong; Akkara, Joseph; Ma, Hong

    2004-04-01

    SCF complexes are the largest and best studied family of E3 ubiquitin protein ligases that facilitate the ubiquitylation of proteins targeted for degradation. The SCF core components Skp1, Cul1, and Rbx1 serve in multiple SCF complexes involving different substrate-specific F-box proteins that are involved in diverse processes including cell cycle and development. In Arabidopsis, mutations in the F-box gene UNUSUAL FLORAL ORGANS (UFO) result in a number of defects in flower development. However, functions of the core components Cul1 and Rbx1 in flower development are poorly understood. In this study we analyzed floral phenotypes caused by altering function of Cul1 or Rbx1, as well as the effects of mutations in ASK1 and ASK2. Plants homozygous for a point mutation in the AtCUL1 gene showed reduced floral organ number and several defects in each of the four whorls. Similarly, plants with reduced AtRbx1 expression due to RNA interference also exhibited floral morphological defects. In addition, compared to the ask1 mutant, plants homozygous for ask1 and heterozygous for ask2 displayed enhanced reduction of B function, as well as other novel defects of flower development, including carpelloid sepals and an inhibition of petal development. Genetic analyses demonstrate that AGAMOUS (AG) is required for the novel phenotypes observed in the first and second whorls. Furthermore, the genetic interaction between UFO and AtCUL1 supports the idea that UFO regulates multiple aspects of flower development as a part of SCF complexes. These results suggest that SCF complexes regulate several aspects of floral development in Arabidopsis.

  12. Developing a complex approach to health phenomena (step 1)

    NASA Astrophysics Data System (ADS)

    Cifuentes, Myriam Patricia

    Health is a complex object for science and operative levels, partly because there are many approaches defining it but not scientifically sufficient or operatively accepted. This is relevant for health understanding but also for decision making on health related problems. "Determinants of Health" as a widely accepted theoretical proposal, identifies as problematic the reductionist view of health as the disease opposite, attempting to develop it positively according to WHO's definition, proposing a set of factors determining health outcomes. Though this allows a larger comprehension of health causes and effects, still has insufficiently defined theoretical statements and unproved assumptions which difficult understanding and effective actions orientation. Complexity deductive modeling since the insufficiently formalized frameworks, implies incorporating unmanageable object assumptions or reducing health broadness. Taking profit of Bogotá government adherence to DH proposal leading a health information system development, was possible inductive modeling since a systemic massive database (690.000 registries). In this way, DH theoretical statements about health components connectedness were explored by classic statistic approach, and by learning Bayesian networks from data (data mining). First approach showed understanding difficulties. Second was advantageous in approximating within and between determinants relationship structure. However, though DH introduces a systemic approach in considering diverse interacting elements is not empirically satisfactory to exhibit all the meaning of health complexity, because just matches analytic fashioned constructs depending on data expression. A strong networked model developing health complexity, needs the orientation by theoretical constructs as human agency and organization, to explore and understand emergent patterns of health.

  13. Using UML Modeling to Facilitate Three-Tier Architecture Projects in Software Engineering Courses

    ERIC Educational Resources Information Center

    Mitra, Sandeep

    2014-01-01

    This article presents the use of a model-centric approach to facilitate software development projects conforming to the three-tier architecture in undergraduate software engineering courses. Many instructors intend that such projects create software applications for use by real-world customers. While it is important that the first version of these…

  14. Longer Term Effects of a Tier 2 Kindergarten Vocabulary Intervention for English Learners

    ERIC Educational Resources Information Center

    Vadasy, Patricia F.; Nelson, J. Ron; Sanders, Elizabeth A.

    2013-01-01

    This study examines the longer term effectiveness of a standard protocol, Tier 2 supplemental vocabulary intervention for kindergarten English learners, designed to develop root word vocabulary knowledge and reinforce beginning word reading skills. Participating students in the original study ("n" = 93 treatment, 92 control) received 20 weeks of…

  15. Diagnosing Students' Misconceptions in Number Sense via a Web-Based Two-Tier Test

    ERIC Educational Resources Information Center

    Lin, Yung-Chi; Yang, Der-Ching; Li, Mao-Neng

    2016-01-01

    A web-based two-tier test (WTTT-NS) which combined the advantages of traditional written tests and interviews in assessing number sense was developed and applied to assess students' answers and reasons for the questions. In addition, students' major misconceptions can be detected. A total of 1,248 sixth graders in Taiwan were selected to…

  16. Web-Based Two-Tier Diagnostic Test and Remedial Learning Experiment

    ERIC Educational Resources Information Center

    Lai, Ah-Fur; Chen, Deng-Jyi

    2010-01-01

    Offering a series of diagnosis and individual remedial learning activities for a general class by means of web and multimedia technology can overcome the dilemma of conventional diagnosis and remedial instruction. The study proposes a three-layer conceptual framework and adopts a two-tier diagnostic test theory to develop a web-based two-tier…

  17. A Three-Tiered Model of Career Counseling Services: ERIC Digest.

    ERIC Educational Resources Information Center

    Kellett, Ralph; Conger, Stuart

    The need for lifelong career development in Canada is becoming increasingly evident as more people switch jobs. To meet this need, it has been suggested that counseling services for adults should be organized in a three-tiered structure. Such a structure would ensure that individuals have access to a counselor in accordance with their level of…

  18. Evaluating Secondary Students' Scientific Reasoning in Genetics Using a Two-Tier Diagnostic Instrument

    ERIC Educational Resources Information Center

    Tsui, Chi-Yan; Treagust, David

    2010-01-01

    While genetics has remained as one key topic in school science, it continues to be conceptually and linguistically difficult for students with the concomitant debates as to what should be taught in the age of biotechnology. This article documents the development and implementation of a two-tier multiple-choice instrument for diagnosing grades 10…

  19. Student Assistance Team (SAT) and the Three Tier Model of Student Intervention

    ERIC Educational Resources Information Center

    Knoblock, Kathleen, Ed.

    2007-01-01

    The term three-tier model of intervention is a model consisting of three well-defined and separate processes running on different levels within a system. In New Mexico, this principle has been applied to develop a model of student intervention for school-aged students. The model has three distinct levels of instructional interventions that account…

  20. JINR Tier-1 centre for the CMS experiment at LHC

    NASA Astrophysics Data System (ADS)

    Astakhov, N. S.; Baginyan, A. S.; Belov, S. D.; Dolbilov, A. G.; Golunov, A. O.; Gorbunov, I. N.; Gromova, N. I.; Kadochnikov, I. S.; Kashunin, I. A.; Korenkov, V. V.; Mitsyn, V. V.; Pelevanyuk, I. S.; Shmatov, S. V.; Strizh, T. A.; Tikhonenko, E. A.; Trofimov, V. V.; Voitishin, N. N.; Zhiltsov, V. E.

    2016-09-01

    An overview of the JINR Tier-1 centre for the CMS experiment at the LHC is given. Special emphasis is placed on the main tasks and services of the CMS Tier-1 at JINR. In February 2015 the JINR CMS Tier-1 resources were increased to the level that was outlined in JINR's rollout plan: CPU 2400 cores (28800 HEP-Spec06), 2.4 PB disks, and 5.0 PB tapes. The first results of the Tier-1 operations received during the LHC Run-2 start are presented.

  1. The Impact of a Tiered Network on Hospital Choice

    PubMed Central

    Frank, Matthew B; Hsu, John; Landrum, Mary Beth; Chernew, Michael E

    2015-01-01

    Objective To evaluate the effect of a tiered network on hospital choice for scheduled admissions. Data The 2009–2012 patient-level claims data from Blue Cross Blue Shield of Massachusetts (BCBSMA). Study Design BCBSMA's three-tiered hospital network employs large differential cost sharing to encourage patients to seek care at hospitals on the preferred tier. During the study period, 44 percent of hospitals were moved to a different tier based on changes in cost or quality performance. We relied on this longitudinal variation for identification and specified conditional logit models to estimate the effect of the tiered network (TN) on patients' hospital choices relative to a non-TN comparison group. Principal Findings The TN was associated with increased use of hospitals on the preferred and middle tiers relative to the nonpreferred tier for planned admissions. The results suggest that if all members were in a TN plan, relative to all members being in a non-TN plan, scheduled admissions to hospitals on the nonpreferred tier would drop by 7.6 percentage points, while those to middle and preferred tier hospitals would rise by 0.9 and 6.6 percentage points, respectively. Conclusion Differential cost sharing can steer patients toward preferred hospitals for planned admissions. PMID:25752219

  2. Core promoter recognition complex changes accompany liver development.

    PubMed

    D'Alessio, Joseph A; Ng, Raymond; Willenbring, Holger; Tjian, Robert

    2011-03-01

    Recent studies of several key developmental transitions have brought into question the long held view of the basal transcriptional apparatus as ubiquitous and invariant. In an effort to better understand the role of core promoter recognition and coactivator complex switching in cellular differentiation, we have examined changes in transcription factor IID (TFIID) and cofactor required for Sp1 activation/Mediator during mouse liver development. Here we show that the differentiation of fetal liver progenitors to adult hepatocytes involves a wholesale depletion of canonical cofactor required for Sp1 activation/Mediator and TFIID complexes at both the RNA and protein level, and that this alteration likely involves silencing of transcription factor promoters as well as protein degradation. It will be intriguing for future studies to determine if a novel and as yet unknown core promoter recognition complex takes the place of TFIID in adult hepatocytes and to uncover the mechanisms that down-regulate TFIID during this critical developmental transition. PMID:21368148

  3. Assessing the Nutritional Quality of Diets of Canadian Adults Using the 2014 Health Canada Surveillance Tool Tier System

    PubMed Central

    Jessri, Mahsa; Nishi, Stephanie K.; L’Abbé, Mary R.

    2015-01-01

    The 2014 Health Canada Surveillance Tool (HCST) was developed to assess adherence of dietary intakes with Canada’s Food Guide. HCST classifies foods into one of four Tiers based on thresholds for sodium, total fat, saturated fat and sugar, with Tier 1 representing the healthiest and Tier 4 foods being the unhealthiest. This study presents the first application of HCST to assess (a) dietary patterns of Canadians; and (b) applicability of this tool as a measure of diet quality among 19,912 adult participants of Canadian Community Health Survey 2.2. Findings indicated that even though most of processed meats and potatoes were Tier 4, the majority of reported foods in general were categorized as Tiers 2 and 3 due to the adjustable lenient criteria used in HCST. Moving from the 1st to the 4th quartile of Tier 4 and “other” foods/beverages, there was a significant trend towards increased calories (1876 kcal vs. 2290 kcal) and “harmful” nutrients (e.g., sodium) as well as decreased “beneficial” nutrients. Compliance with the HCST was not associated with lower body mass index. Future nutrient profiling systems need to incorporate both “positive” and “negative” nutrients, an overall score and a wider range of nutrient thresholds to better capture food product differences. PMID:26703721

  4. Development of the Neurochemical Architecture of the Central Complex

    PubMed Central

    Boyan, George S.; Liu, Yu

    2016-01-01

    The central complex represents one of the most conspicuous neuroarchitectures to be found in the insect brain and regulates a wide repertoire of behaviors including locomotion, stridulation, spatial orientation and spatial memory. In this review article, we show that in the grasshopper, a model insect system, the intricate wiring of the fan-shaped body (FB) begins early in embryogenesis when axons from the first progeny of four protocerebral stem cells (called W, X, Y, Z, respectively) in each brain hemisphere establish a set of tracts to the primary commissural system. Decussation of subsets of commissural neurons at stereotypic locations across the brain midline then establishes a columnar neuroarchitecture in the FB which is completed during embryogenesis. Examination of the expression patterns of various neurochemicals in the central complex including neuropeptides, a neurotransmitter and the gas nitric oxide (NO), show that these appear progressively and in a substance-specific manner during embryogenesis. Each neuroactive substance is expressed by neurons located at stereotypic locations in a given central complex lineage, confirming that the stem cells are biochemically multipotent. The organization of axons expressing the various neurochemicals within the central complex is topologically related to the location, and hence birthdate, of the neurons within the lineages. The neurochemical expression patterns within the FB are layered, and so reflect the temporal topology present in the lineages. This principle relates the neuroanatomical to the neurochemical architecture of the central complex and so may provide insights into the development of adaptive behaviors.

  5. Development of the Neurochemical Architecture of the Central Complex.

    PubMed

    Boyan, George S; Liu, Yu

    2016-01-01

    The central complex represents one of the most conspicuous neuroarchitectures to be found in the insect brain and regulates a wide repertoire of behaviors including locomotion, stridulation, spatial orientation and spatial memory. In this review article, we show that in the grasshopper, a model insect system, the intricate wiring of the fan-shaped body (FB) begins early in embryogenesis when axons from the first progeny of four protocerebral stem cells (called W, X, Y, Z, respectively) in each brain hemisphere establish a set of tracts to the primary commissural system. Decussation of subsets of commissural neurons at stereotypic locations across the brain midline then establishes a columnar neuroarchitecture in the FB which is completed during embryogenesis. Examination of the expression patterns of various neurochemicals in the central complex including neuropeptides, a neurotransmitter and the gas nitric oxide (NO), show that these appear progressively and in a substance-specific manner during embryogenesis. Each neuroactive substance is expressed by neurons located at stereotypic locations in a given central complex lineage, confirming that the stem cells are biochemically multipotent. The organization of axons expressing the various neurochemicals within the central complex is topologically related to the location, and hence birthdate, of the neurons within the lineages. The neurochemical expression patterns within the FB are layered, and so reflect the temporal topology present in the lineages. This principle relates the neuroanatomical to the neurochemical architecture of the central complex and so may provide insights into the development of adaptive behaviors. PMID:27630548

  6. Development of the Neurochemical Architecture of the Central Complex

    PubMed Central

    Boyan, George S.; Liu, Yu

    2016-01-01

    The central complex represents one of the most conspicuous neuroarchitectures to be found in the insect brain and regulates a wide repertoire of behaviors including locomotion, stridulation, spatial orientation and spatial memory. In this review article, we show that in the grasshopper, a model insect system, the intricate wiring of the fan-shaped body (FB) begins early in embryogenesis when axons from the first progeny of four protocerebral stem cells (called W, X, Y, Z, respectively) in each brain hemisphere establish a set of tracts to the primary commissural system. Decussation of subsets of commissural neurons at stereotypic locations across the brain midline then establishes a columnar neuroarchitecture in the FB which is completed during embryogenesis. Examination of the expression patterns of various neurochemicals in the central complex including neuropeptides, a neurotransmitter and the gas nitric oxide (NO), show that these appear progressively and in a substance-specific manner during embryogenesis. Each neuroactive substance is expressed by neurons located at stereotypic locations in a given central complex lineage, confirming that the stem cells are biochemically multipotent. The organization of axons expressing the various neurochemicals within the central complex is topologically related to the location, and hence birthdate, of the neurons within the lineages. The neurochemical expression patterns within the FB are layered, and so reflect the temporal topology present in the lineages. This principle relates the neuroanatomical to the neurochemical architecture of the central complex and so may provide insights into the development of adaptive behaviors. PMID:27630548

  7. Insect Antimicrobial Peptide Complexes Prevent Resistance Development in Bacteria

    PubMed Central

    Chernysh, Sergey; Gordya, Natalia; Suborova, Tatyana

    2015-01-01

    In recent decades much attention has been paid to antimicrobial peptides (AMPs) as natural antibiotics, which are presumably protected from resistance development in bacteria. However, experimental evolution studies have revealed prompt resistance increase in bacteria to any individual AMP tested. Here we demonstrate that naturally occurring compounds containing insect AMP complexes have clear advantage over individual peptide and small molecule antibiotics in respect of drug resistance development. As a model we have used the compounds isolated from bacteria challenged maggots of Calliphoridae flies. The compound isolated from blow fly Calliphora vicina was found to contain three distinct families of cell membrane disrupting/permeabilizing peptides (defensins, cecropins and diptericins), one family of proline rich peptides and several unknown antimicrobial substances. Resistance changes under long term selective pressure of the compound and reference antibiotics cefotaxime, meropenem and polymyxin B were tested using Escherichia coli, Klebsiella pneumonia and Acinetobacter baumannii clinical strains. All the strains readily developed resistance to the reference antibiotics, while no signs of resistance growth to the compound were registered. Similar results were obtained with the compounds isolated from 3 other fly species. The experiments revealed that natural compounds containing insect AMP complexes, in contrast to individual AMP and small molecule antibiotics, are well protected from resistance development in bacteria. Further progress in the research of natural AMP complexes may provide novel solutions to the drug resistance problem. PMID:26177023

  8. Managing Programmatic Risk for Complex Space System Developments

    NASA Technical Reports Server (NTRS)

    Panetta, Peter V.; Hastings, Daniel; Brumfield, Mark (Technical Monitor)

    2001-01-01

    Risk management strategies have become a recent important research topic to many aerospace organizations as they prepare to develop the revolutionary complex space systems of the future. Future multi-disciplinary complex space systems will make it absolutely essential for organizations to practice a rigorous, comprehensive risk management process, emphasizing thorough systems engineering principles to succeed. Project managers must possess strong leadership skills to direct high quality, cross-disciplinary teams for successfully developing revolutionary space systems that are ever increasing in complexity. Proactive efforts to reduce or eliminate risk throughout a project's lifecycle ideally must be practiced by all technical members in the organization. This paper discusses some of the risk management perspectives that were collected from senior managers and project managers of aerospace and aeronautical organizations by the use of interviews and surveys. Some of the programmatic risks which drive the success or failure of projects are revealed. Key findings lead to a number of insights for organizations to consider for proactively approaching the risks which face current and future complex space systems projects.

  9. Macrocyclic metal complexes for metalloenzyme mimicry and sensor development.

    PubMed

    Joshi, Tanmaya; Graham, Bim; Spiccia, Leone

    2015-08-18

    Examples of proteins that incorporate one or more metal ions within their structure are found within a broad range of classes, including oxidases, oxidoreductases, reductases, proteases, proton transport proteins, electron transfer/transport proteins, storage proteins, lyases, rusticyanins, metallochaperones, sporulation proteins, hydrolases, endopeptidases, luminescent proteins, iron transport proteins, oxygen storage/transport proteins, calcium binding proteins, and monooxygenases. The metal coordination environment therein is often generated from residues inherent to the protein, small exogenous molecules (e.g., aqua ligands) and/or macrocyclic porphyrin units found, for example, in hemoglobin, myoglobin, cytochrome C, cytochrome C oxidase, and vitamin B12. Thus, there continues to be considerable interest in employing macrocyclic metal complexes to construct low-molecular weight models for metallobiosites that mirror essential features of the coordination environment of a bound metal ion without inclusion of the surrounding protein framework. Herein, we review and appraise our research exploring the application of the metal complexes formed by two macrocyclic ligands, 1,4,7-triazacyclononane (tacn) and 1,4,7,10-tetraazacyclododecane (cyclen), and their derivatives in biological inorganic chemistry. Taking advantage of the kinetic inertness and thermodynamic stability of their metal complexes, these macrocyclic scaffolds have been employed in the development of models that aid the understanding of metal ion-binding natural systems, and complexes with potential applications in biomolecule sensing, diagnosis, and therapy. In particular, the focus has been on "coordinatively unsaturated" metal complexes that incorporate a kinetically inert and stable metal-ligand moiety, but which also contain one or more weakly bound ligands, allowing for the reversible binding of guest molecules via the formation and dissociation of coordinate bonds. With regards to mimicking

  10. The Study on Complex Project Management in Developing Countries

    NASA Astrophysics Data System (ADS)

    Yanwen, Wang

    Different factors that can influence project performance have been identified, classified based on their nature, and discussed. Due to the inherent complexity and various problems encountered in implementing infrastructure project in developing countries, the project manager must appreciate the project environment, maintain flexibility, and be competent to analyze the nature of associated problems and their adverse effects on the success of the project, and address these promptly.

  11. [Cellular immunotherapy: complexity of immune system and industrial development].

    PubMed

    Abastado, J-P

    2003-01-01

    Cell immunotherapy aims at treating patients by stimulating their own immune system using appropriate cells. This approach is one of the most promising therapeutic strategy against cancer. The use of cells, the mobilization of a system, the targeting of interactions between the immune system and the tumor constitute the hallmarks of complexity, an area of intense academic and industrial research during the past twenty years. The present article reviews some unique characteristics of the industrial development of these cell drugs.

  12. A multi-tiered wavefront sensor using binary optics

    SciTech Connect

    Neal, D.R.; Warren, M.E.; Gruetzner, J.K.; Smith, T.G.; Rosenthal, R.R.; McKechnie, T.S.

    1994-05-01

    Wavefront sensors have been used to make measurements in fluid- dynamics and for closed loop control of adaptive optics. In most common Shack-Hartmann wavefront wavefront sensors, the light is broken up into series of rectangular or hexagonal apertures that divide the light into a series of focal spots. The position of these focal spots is used to determine the wavefront slopes over each subaperture. Using binary optics technology, we have developed a hierarchical or fractal wavefront sensor that divides the subapertures up on a more optimal fashion. We have demonstrated this concept for up to four tiers and developed the wavefront reconstruction methods for both segmented adaptive optics and continous wavefront measurement.

  13. A tiered observational system for anthropogenic methane emissions

    NASA Astrophysics Data System (ADS)

    Duren, R. M.; Miller, C. E.; Hulley, G. C.; Hook, S. J.; Sander, S. P.

    2014-12-01

    Improved understanding of anthropogenic methane emissions is required for closing the global carbon budget and addressing priority challenges in climate policy. Several decades of top-down and bottom-up studies show that anthropogenic methane emissions are systematically underestimated in key regions and economic sectors. These uncertainties have been compounded by the dramatic rise of disruptive technologies (e.g., the transformation in the US energy system due to unconventional gas and oil production). Methane flux estimates derived from inverse analyses and aircraft-based mass balance approaches underscore the disagreement in nationally and regionally reported methane emissions as well as the possibility of a long-tail distribution in fugitive emissions spanning the US natural gas supply chain; i.e. a small number of super-emitters may be responsible for most of the observed anomalies. Other studies highlight the challenges of sectoral and spatial attribution of fugitive emissions - including the relative contributions of dairies vs oil and gas production or disentangling the contributions of natural gas transmission, distribution, and consumption or landfill emissions in complex urban environments. Limited observational data remains a foundational barrier to resolving these challenges. We present a tiered observing system strategy for persistent, high-frequency monitoring over large areas to provide remote detection, geolocation and quantification of significant anthropogenic methane emissions across cities, states, basins and continents. We describe how this would both improve confidence in methane emission estimates and expedite resolution of fugitive emissions and leaks. We summarize recent prototype field campaigns that employ multiple vantage points and measurement techniques (including NASA's CARVE and HyTES aircraft and PanFTS instrument on Mt Wilson). We share preliminary results of this tiered observational approach including examples of individual

  14. Estimation of the incidence of a rare genetic disease through a two-tier mutation survey

    SciTech Connect

    Chakraborty, R.; Srinivasan, M.R. ); Raskin, S. Universidade Federal do Parana, Curitiba )

    1993-06-01

    Recent attempts to detect mutations involving single base changes or small deletions that are specific to genetic diseases provide an opportunity to develop a two-tier mutation-screening program through which incidence of rare genetic disorders and gene carriers may be precisely estimated. A two-tier survey consists of mutation screening in a sample of patients with specific genetic disorders and in a second sample of newborns from the same population in which mutation frequency is evaluated. The authors provide the statistical basis for evaluating the incidence of affected and gene carriers in such two-tier mutation-screening surveys, from which the precision of the estimates is derived. Sample-size requirements of such two-tier mutation-screening surveys are evaluated. Considering examples of cystic fibrosis (CF) and medium-chain acyl-CoA dehydrogenase deficiency (MCAD), the two most frequent autosomal recessive diseases in Caucasian populations and the two most frequent mutations ([Delta]F508 and G985) that occur on these disease allele-bearing chromosomes, the authors show that, with 50--100 patients and a 20-fold larger sample of newborns screened for these mutations, the incidence of such diseases and their gene carriers in a population may be quite reliably estimated. The theory developed here is also applicable to rare autosomal dominant diseases for which disease-specific mutations are found. 21 refs., 1 fig., 3 tabs.

  15. Synthetic aperture radar processing with tiered subapertures

    SciTech Connect

    Doerry, A.W.

    1994-06-01

    Synthetic Aperture Radar (SAR) is used to form images that are maps of radar reflectivity of some scene of interest, from range soundings taken over some spatial aperture. Additionally, the range soundings are typically synthesized from a sampled frequency aperture. Efficient processing of the collected data necessitates using efficient digital signal processing techniques such as vector multiplies and fast implementations of the Discrete Fourier Transform. Inherent in image formation algorithms that use these is a trade-off between the size of the scene that can be acceptably imaged, and the resolution with which the image can be made. These limits arise from migration errors and spatially variant phase errors, and different algorithms mitigate these to varying degrees. Two fairly successful algorithms for airborne SARs are Polar Format processing, and Overlapped Subaperture (OSA) processing. This report introduces and summarizes the analysis of generalized Tiered Subaperture (TSA) techniques that are a superset of both Polar Format processing and OSA processing. It is shown how tiers of subapertures in both azimuth and range can effectively mitigate both migration errors and spatially variant phase errors to allow virtually arbitrary scene sizes, even in a dynamic motion environment.

  16. 26 CFR 1.444-4 - Tiered structure.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 6 2012-04-01 2012-04-01 false Tiered structure. 1.444-4 Section 1.444-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Accounting Periods § 1.444-4 Tiered structure. (a) Electing small...

  17. 26 CFR 1.444-4 - Tiered structure.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 6 2013-04-01 2013-04-01 false Tiered structure. 1.444-4 Section 1.444-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Accounting Periods § 1.444-4 Tiered structure. (a) Electing small...

  18. 26 CFR 1.444-4 - Tiered structure.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 6 2014-04-01 2014-04-01 false Tiered structure. 1.444-4 Section 1.444-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Accounting Periods § 1.444-4 Tiered structure. (a) Electing small...

  19. 26 CFR 1.444-4 - Tiered structure.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 6 2010-04-01 2010-04-01 false Tiered structure. 1.444-4 Section 1.444-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Accounting Periods § 1.444-4 Tiered structure. (a) Electing small business trusts....

  20. 26 CFR 1.444-4 - Tiered structure.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 6 2011-04-01 2011-04-01 false Tiered structure. 1.444-4 Section 1.444-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Accounting Periods § 1.444-4 Tiered structure. (a) Electing small...

  1. Action Research: Tiered Instruction in a High School Physics Course

    ERIC Educational Resources Information Center

    Courville, Keith

    2010-01-01

    (Purpose) This article describes the use of tiered instruction, a specific form of differentiation, within the author's high school Physics classroom. A background and discussion on the nature of tiered instruction is also included. (Findings) Topics addressed in this paper include: (1) the necessity of differentiation within the classroom; (2)…

  2. 47 CFR 76.1618 - Basic tier availability.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Basic tier availability. 76.1618 Section 76.1618 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Notices § 76.1618 Basic tier availability. A cable...

  3. 47 CFR 76.1618 - Basic tier availability.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 4 2013-10-01 2013-10-01 false Basic tier availability. 76.1618 Section 76.1618 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Notices § 76.1618 Basic tier availability. A cable...

  4. 47 CFR 76.1618 - Basic tier availability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Basic tier availability. 76.1618 Section 76.1618 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Notices § 76.1618 Basic tier availability. A cable...

  5. 47 CFR 76.1618 - Basic tier availability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Basic tier availability. 76.1618 Section 76.1618 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Notices § 76.1618 Basic tier availability. A cable...

  6. 47 CFR 76.1618 - Basic tier availability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 4 2014-10-01 2014-10-01 false Basic tier availability. 76.1618 Section 76.1618 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Notices § 76.1618 Basic tier availability. A cable...

  7. 47 CFR 76.1605 - New product tier.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false New product tier. 76.1605 Section 76.1605 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Notices § 76.1605 New product tier. (a) Within 30 days of the offering of...

  8. Using Brief Experimental Analysis to Intensify Tier 3 Reading Interventions

    ERIC Educational Resources Information Center

    Coolong-Chaffin, Melissa; Wagner, Dana

    2015-01-01

    As implementation of multi-tiered systems of support becomes common practice across the nation, practitioners continue to need strategies for intensifying interventions and supports for the subset of students who fail to make adequate progress despite strong programs at Tiers 1 and 2. Experts recommend making several changes to the structure and…

  9. The Development and Study of Surface Bound Ruthenium Organometallic Complexes

    NASA Astrophysics Data System (ADS)

    Abbott, Geoffrey Reuben

    The focus of this project has been on the use of mono-diimine ruthenium organometallic complexes, of the general structure [H(Ru)(CO)(L)2(L') 2][PF6] (L=PPh3, DPPENE and L'=Bpy, DcBpy, MBpyC, Phen, AminoPhen) bound to surfaces as luminescent probes. Both biological and inorganic/organic hybrid surfaces have been studied. The complexes were characterized both bound and unbound using standard analytical techniques such as NMR, IR and X-ray crystallography, as well as through several photophysical methods as well. Initially the study focused on how the photophyscial properties of the complexes were affected by incorporation into biological membranes. It was found that by conjugating the probes to a more rigid cholesterol moiety that luminescence was conserved, compared to conjugation with a far more flexible lipid moiety, where luminescence was either lost or reduced. Both the cholesterol and lipid conjugates were able to insert into a lipid membrane, and in the more rigid environment some of the lipid conjugates regained some of their luminescence, but often blue shifted and reduced, depending on the conjugation site. Silica Polyamine Composites (SPCs) were a hybrid material developed in the Rosenberg Lab as useful metal separation materials, that could be easily modified, and had several benefits over current commercially available polymers, or inorganic materials. These SPCs also provided an opportunity for the development of a heterogeneous platform for luminescent complexes as either catalysts or sensors. Upon binding of the luminescent Ru complexes to the surface no loss, or major change in luminescence was seen, however, when bound to the rigid surface a significant increase in excited state lifetime was measured. It is likely that through binding and interacting with the surface that the complexes lost non-radiative decay pathways, resulting in the increase in lifetime, however, these interactions do not seem to affect the energy level of the MLCT band in a

  10. Aircraft stress sequence development: A complex engineering process made simple

    NASA Technical Reports Server (NTRS)

    Schrader, K. H.; Butts, D. G.; Sparks, W. A.

    1994-01-01

    Development of stress sequences for critical aircraft structure requires flight measured usage data, known aircraft loads, and established relationships between aircraft flight loads and structural stresses. Resulting cycle-by-cycle stress sequences can be directly usable for crack growth analysis and coupon spectra tests. Often, an expert in loads and spectra development manipulates the usage data into a typical sequence of representative flight conditions for which loads and stresses are calculated. For a fighter/trainer type aircraft, this effort is repeated many times for each of the fatigue critical locations (FCL) resulting in expenditure of numerous engineering hours. The Aircraft Stress Sequence Computer Program (ACSTRSEQ), developed by Southwest Research Institute under contract to San Antonio Air Logistics Center, presents a unique approach for making complex technical computations in a simple, easy to use method. The program is written in Microsoft Visual Basic for the Microsoft Windows environment.

  11. 40 CFR 370.43 - What codes are used to report Tier I and Tier II inventory information?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 27 2010-07-01 2010-07-01 false What codes are used to report Tier I and Tier II inventory information? 370.43 Section 370.43 Protection of Environment ENVIRONMENTAL... volume to weight in pounds, multiply by an appropriate density factor. (b) Storage type codes. Except...

  12. Nano-scale, planar and multi-tiered current pathways from a carbon nanotube-copper composite with high conductivity, ampacity and stability.

    PubMed

    Subramaniam, Chandramouli; Sekiguchi, Atsuko; Yamada, Takeo; Futaba, Don N; Hata, Kenji

    2016-02-21

    New lithographically processable materials with high ampacity are in demand to meet the increasing requirement for high operational current density at high temperatures existing in current pathways within electronic devices. To meet this demand, we report an approach to fabricate a high ampacity (∼100 times higher than Cu) carbon nanotube-copper (CNT-Cu) composite into a variety of complex nano-scale, planar and multi-tiered current pathways. The approach involved the use of a two-stage electrodeposition of copper into a pre-patterned template of porous, thin CNT sheets acting as the electrode. The versatility of this approach enabled the realization of completely suspended multi-tier, dielectric-less 'air-gap' CNT-Cu circuits that could be electrically isolated from each other and are challenging to fabricate with pure Cu or any metal. Importantly, all such complex structures, ranging from 500 nm to 20 μm in width, exhibited ∼100-times higher ampacity than any known metal, with comparable electrical conductivity as Cu. In addition, CNT-Cu structures also exhibited a superior temperature stability compared to the ∼10-times wider Cu counterparts. We believe that the combination of our approach and the properties demonstrated here are vital achievements for the future development of efficient and powerful electrical devices.

  13. Nano-scale, planar and multi-tiered current pathways from a carbon nanotube-copper composite with high conductivity, ampacity and stability

    NASA Astrophysics Data System (ADS)

    Subramaniam, Chandramouli; Sekiguchi, Atsuko; Yamada, Takeo; Futaba, Don N.; Hata, Kenji

    2016-02-01

    New lithographically processable materials with high ampacity are in demand to meet the increasing requirement for high operational current density at high temperatures existing in current pathways within electronic devices. To meet this demand, we report an approach to fabricate a high ampacity (~100 times higher than Cu) carbon nanotube-copper (CNT-Cu) composite into a variety of complex nano-scale, planar and multi-tiered current pathways. The approach involved the use of a two-stage electrodeposition of copper into a pre-patterned template of porous, thin CNT sheets acting as the electrode. The versatility of this approach enabled the realization of completely suspended multi-tier, dielectric-less `air-gap' CNT-Cu circuits that could be electrically isolated from each other and are challenging to fabricate with pure Cu or any metal. Importantly, all such complex structures, ranging from 500 nm to 20 μm in width, exhibited ~100-times higher ampacity than any known metal, with comparable electrical conductivity as Cu. In addition, CNT-Cu structures also exhibited a superior temperature stability compared to the ~10-times wider Cu counterparts. We believe that the combination of our approach and the properties demonstrated here are vital achievements for the future development of efficient and powerful electrical devices.

  14. DAX1 and its network partners: exploring complexity in development.

    PubMed

    Clipsham, Robert; McCabe, Edward R B

    2003-01-01

    DAX1 encoded by NR0B1, when mutated, is responsible for X-linked adrenal hypoplasia congenita (AHC). AHC is due to failure of the adrenal cortex to develop normally and is fatal if untreated. When duplicated, this gene is associated with an XY sex-reversed phenotype. DAX1 expression is present during development of the steroidogenic hypothalamic-pituitary-adrenal-gonadal (HPAG) axis and persists into adult life. Despite recognition of the crucial role for DAX1, its function remains largely undefined. The phenotypes of patients and animal models are complex and not always in agreement. Investigations using cell lines have proved difficult to interpret, possibly reflecting cell line choices and their limited characterization. We will review the efforts of our group and others to identify appropriate cell lines for optimizing ex vivo analysis of NR0B1 function throughout development. We will examine the role of DAX1 and its network partners in development of the hypothalamic-pituitary-adrenal/gonadal axis (HPAG) using a variety of different types of investigations, including those in model organisms. This network analysis will help us to understand normal and abnormal development of the HPAG. In addition, these studies permit identification of candidate genes for human inborn errors of HPAG development.

  15. Developing a theoretical framework for complex community-based interventions.

    PubMed

    Angeles, Ricardo N; Dolovich, Lisa; Kaczorowski, Janusz; Thabane, Lehana

    2014-01-01

    Applying existing theories to research, in the form of a theoretical framework, is necessary to advance knowledge from what is already known toward the next steps to be taken. This article proposes a guide on how to develop a theoretical framework for complex community-based interventions using the Cardiovascular Health Awareness Program as an example. Developing a theoretical framework starts with identifying the intervention's essential elements. Subsequent steps include the following: (a) identifying and defining the different variables (independent, dependent, mediating/intervening, moderating, and control); (b) postulating mechanisms how the independent variables will lead to the dependent variables; (c) identifying existing theoretical models supporting the theoretical framework under development; (d) scripting the theoretical framework into a figure or sets of statements as a series of hypotheses, if/then logic statements, or a visual model; (e) content and face validation of the theoretical framework; and (f) revising the theoretical framework. In our example, we combined the "diffusion of innovation theory" and the "health belief model" to develop our framework. Using the Cardiovascular Health Awareness Program as the model, we demonstrated a stepwise process of developing a theoretical framework. The challenges encountered are described, and an overview of the strategies employed to overcome these challenges is presented.

  16. [Development, health-industrial complex and industrial policy].

    PubMed

    Gadelha, Carlos Augusto Grabois

    2006-08-01

    This paper puts health questions within the context of national development and industrial policy. It follows the idea of structuralist, Marxist and Schumpeterian approaches, in which industry and innovations form determining factors for the dynamism in capitalist economies and relative positions within the world economy. All countries that have developed and started to compete under better conditions with advanced countries have had an association between strong industry and an endogenous knowledge, learning and innovation base. However, in the field of health, this vision presents problems because business interests move according to the economic logic of profit rather than to meet health needs. The notion of the health-industrial complex is an attempt to provide a theoretical reference that enables linkage between two distinct types of logic: health and economic development. This study has sought to show, on the basis of foreign trade data, how disregard for the logic of health policy development has led to a situation of economic vulnerability in this sector, which may limit the objectives of universality, equality and comprehensiveness. Within this context, a cognitive and political break with these antagonistic visions that put health needs on one side and industrial needs on the other is proposed. A country that aims to reach a condition of development and independence requires strong innovative industries and an inclusive and universal health system, at the same time. PMID:16924298

  17. Multi-tiered system of support incorporating the R.E.N.E.W. process and its relationship to perception of school safety and office discipline referrals

    NASA Astrophysics Data System (ADS)

    Flood, Molly M.

    This study examined the relationship between the fidelity of multi-tier school-wide positive behavior interventions and supports (SWPBIS) and staff perception of school safety and office discipline referrals. This research provided a case study on multi-tier supports and interventions, and the RENEW person-centered planning process in an alternative special education center following the implementation of a multi-tier SWPBIS model. Pennsylvania is one of several states looking to adopt an effective Tier III behavioral tool. The research described the results of an analysis of implementation fidelity on a multi-tiered school-wide positive behavior support model developed at a special education center operated by a public school system entity. This research explored the fidelity of SWPBIS implementation; analyzed the relationship of SWPBIS to school climate as measured by staff perceptions and reduction of office discipline referrals (ODR); explored tier III supports incorporating a process Rehabilitation and Empowerment, Natural Supports, Education and Work (RENEW); and investigated the potential sustainability of the RENEW process as a multi-tier system of support. This study investigated staff perceptions on integrated supports between schools and communities and identified the degree of relationship to school risk factors, school protective factors, and office discipline referrals following the building of cooperative partnerships between Systems of Care and Local Education Agencies.

  18. Development and infectious disease in hosts with complex life cycles.

    PubMed

    Searle, Catherine L; Xie, Gisselle Yang; Blaustein, Andrew R

    2013-01-01

    Metamorphosis is often characterized by profound changes in morphology and physiology that can affect the dynamics of species interactions. For example, the interaction between a pathogen and its host may differ depending on the life stage of the host or pathogen. One pathogen that infects hosts with complex life cycles is the emerging fungal pathogen of amphibians, Batrachochytrium dendrobatidis (Bd). We sought to determine how conditions at the larval stage can affect variation in development and patterns of Bd infection across amphibian life stages. We used outdoor experimental mesocosms to simulate natural pond habitats and manipulated the presence of Bd, the larval density, and the number of host species in larvae of two co-occurring amphibian species (Rana cascadae and Pseudacris regilla). We found that infection differed between species throughout development; P. regilla consistently had higher infection severity compared to R. cascadae. Additionally, while up to 100% of larvae were infected, only 18.2% of R. cascadae and 81.5% of P. regilla were infected after metamorphosis. This indicates that amphibians have the ability to recover from Bd infection as they undergo metamorphosis. Higher larval densities in P. regilla led to a shorter larval period, and individuals with a shorter larval period had lower infection severity. This led to a trend where P. regilla larvae reared at high densities tended to have lower infection prevalence after metamorphosis. We also found that exposure to Bd increased larval mortality and prolonged the larval period in P. regilla, indicating that P. regilla are susceptible to the negative effects of Bd as larvae. This study demonstrates that host density, species composition, and pathogen exposure may all interact to influence development and infection in hosts with complex life cycles.

  19. Development and Infectious Disease in Hosts with Complex Life Cycles

    PubMed Central

    Searle, Catherine L.; Xie, Gisselle Yang; Blaustein, Andrew R.

    2013-01-01

    Metamorphosis is often characterized by profound changes in morphology and physiology that can affect the dynamics of species interactions. For example, the interaction between a pathogen and its host may differ depending on the life stage of the host or pathogen. One pathogen that infects hosts with complex life cycles is the emerging fungal pathogen of amphibians, Batrachochytrium dendrobatidis (Bd). We sought to determine how conditions at the larval stage can affect variation in development and patterns of Bd infection across amphibian life stages. We used outdoor experimental mesocosms to simulate natural pond habitats and manipulated the presence of Bd, the larval density, and the number of host species in larvae of two co-occurring amphibian species (Rana cascadae and Pseudacris regilla). We found that infection differed between species throughout development; P. regilla consistently had higher infection severity compared to R. cascadae. Additionally, while up to 100% of larvae were infected, only 18.2% of R. cascadae and 81.5% of P. regilla were infected after metamorphosis. This indicates that amphibians have the ability to recover from Bd infection as they undergo metamorphosis. Higher larval densities in P. regilla led to a shorter larval period, and individuals with a shorter larval period had lower infection severity. This led to a trend where P. regilla larvae reared at high densities tended to have lower infection prevalence after metamorphosis. We also found that exposure to Bd increased larval mortality and prolonged the larval period in P. regilla, indicating that P. regilla are susceptible to the negative effects of Bd as larvae. This study demonstrates that host density, species composition, and pathogen exposure may all interact to influence development and infection in hosts with complex life cycles. PMID:23565288

  20. Major histocompatibility complex I in brain development and schizophrenia.

    PubMed

    McAllister, A Kimberley

    2014-02-15

    Although the etiology of schizophrenia (SZ) remains unknown, it is increasingly clear that immune dysregulation plays a central role. Genome-wide association studies reproducibly indicate an association of SZ with immune genes within the major histocompatibility complex (MHC). Moreover, environmental factors that increase risk for SZ, such as maternal infection, alter peripheral immune responses as well as the expression of immune molecules in the brain. MHC class I (MHCI) molecules might mediate both genetic and environmental contributions to SZ through direct effects on brain development in addition to mediating immunity. MHCI molecules are expressed on neurons in the central nervous system throughout development and into adulthood, where they regulate many aspects of brain development, including neurite outgrowth, synapse formation and function, long-term and homeostatic plasticity, and activity-dependent synaptic refinement. This review summarizes our current understanding of MHCI expression and function in the developing brain as well as its involvement in maternal immune activation, from the perspective of how these roles for MHCI molecules might contribute to the pathogenesis of SZ.

  1. Structural complexity and the time course of grammatical development.

    PubMed

    Frank, R

    1998-06-01

    a new type of explanation for the time course of syntactic development in terms of the complexity of formal grammatical devices.

  2. SLA-based optimisation of virtualised resource for multi-tier web applications in cloud data centres

    NASA Astrophysics Data System (ADS)

    Bi, Jing; Yuan, Haitao; Tie, Ming; Tan, Wei

    2015-10-01

    Dynamic virtualised resource allocation is the key to quality of service assurance for multi-tier web application services in cloud data centre. In this paper, we develop a self-management architecture of cloud data centres with virtualisation mechanism for multi-tier web application services. Based on this architecture, we establish a flexible hybrid queueing model to determine the amount of virtual machines for each tier of virtualised application service environments. Besides, we propose a non-linear constrained optimisation problem with restrictions defined in service level agreement. Furthermore, we develop a heuristic mixed optimisation algorithm to maximise the profit of cloud infrastructure providers, and to meet performance requirements from different clients as well. Finally, we compare the effectiveness of our dynamic allocation strategy with two other allocation strategies. The simulation results show that the proposed resource allocation method is efficient in improving the overall performance and reducing the resource energy cost.

  3. 26 CFR 53.4961-1 - Abatement of second tier taxes for correction within correction period.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 17 2013-04-01 2013-04-01 false Abatement of second tier taxes for correction... TAXES Second Tier Excise Taxes § 53.4961-1 Abatement of second tier taxes for correction within... second tier tax imposed with respect to the event shall not be assessed. If the tax has been assessed,...

  4. 26 CFR 53.4961-1 - Abatement of second tier taxes for correction within correction period.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 17 2012-04-01 2012-04-01 false Abatement of second tier taxes for correction... TAXES Second Tier Excise Taxes § 53.4961-1 Abatement of second tier taxes for correction within... second tier tax imposed with respect to the event shall not be assessed. If the tax has been assessed,...

  5. 26 CFR 53.4961-1 - Abatement of second tier taxes for correction within correction period.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 17 2014-04-01 2014-04-01 false Abatement of second tier taxes for correction... TAXES Second Tier Excise Taxes § 53.4961-1 Abatement of second tier taxes for correction within... second tier tax imposed with respect to the event shall not be assessed. If the tax has been assessed,...

  6. 26 CFR 53.4961-1 - Abatement of second tier taxes for correction within correction period.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 17 2010-04-01 2010-04-01 false Abatement of second tier taxes for correction... TAXES Second Tier Excise Taxes § 53.4961-1 Abatement of second tier taxes for correction within... second tier tax imposed with respect to the event shall not be assessed. If the tax has been assessed,...

  7. 26 CFR 53.4961-1 - Abatement of second tier taxes for correction within correction period.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 17 2011-04-01 2011-04-01 false Abatement of second tier taxes for correction... TAXES Second Tier Excise Taxes § 53.4961-1 Abatement of second tier taxes for correction within... second tier tax imposed with respect to the event shall not be assessed. If the tax has been assessed,...

  8. Tier 2 Interventions in Positive Behavior Support: A Survey of School Implementation

    ERIC Educational Resources Information Center

    Rodriguez, Billie Jo; Loman, Sheldon L.; Borgmeier, Christopher

    2016-01-01

    As increasing numbers of schools implement Multi-Tiered Systems of Support (MTSS), schools are looking for and implementing evidence-based practices for students whose needs are not fully met by Tier 1 supports. Although there is relative consistency and clarity in what constitutes Tier 1 behavior support within MTSS, Tier 2 supports may be more…

  9. A Team-Based Process for Designing Comprehensive, Integrated, Three-Tiered (CI3T) Models of Prevention: How Does My School-Site Leadership Team Design a CI3T Model?

    ERIC Educational Resources Information Center

    Lane, Kathleen Lynne; Oakes, Wendy Peia; Jenkins, Abbie; Menzies, Holly Mariah; Kalberg, Jemma Robertson

    2014-01-01

    Comprehensive, integrated, three-tiered models are context specific and developed by school-site teams according to the core values held by the school community. In this article, the authors provide a step-by-step, team-based process for designing comprehensive, integrated, three-tiered models of prevention that integrate academic, behavioral, and…

  10. Application of elements of microbiological risk assessment in the food industry via a tiered approach.

    PubMed

    van Gerwen, Suzanne J C; Gorris, Leon G M

    2004-09-01

    Food safety control is a matter for concern for all parts of the food supply chain, including governments that develop food safety policy, food industries that must control potential hazards, and consumers who need to keep to the intended use of the food. In the future, food safety policy may be set using the framework of risk analysis, part of which is the development of (inter)national microbiological risk assessment (MRA) studies. MRA studies increase our understanding of the impact of risk management interventions and of the relationships among subsequent parts of food supply chains with regard to the safety of the food when it reaches the consumer. Application of aspects of MRA in the development of new food concepts has potential benefits for the food industry. A tiered approach to applying MRA can best realize these benefits. The tiered MRA approach involves calculation of microbial fate for a product and process design on the basis of experimental data (e.g., monitoring data on prevalence) and predictive microbiological models. Calculations on new product formulations and novel processing technologies provide improved understanding of microbial fate beyond currently known boundaries, which enables identification of new opportunities in process design. The outcome of the tiered approach focuses on developing benchmarks of potential consumer exposure to hazards associated with new products by comparison with exposure associated with products that are already on the market and have a safe history of use. The tiered prototype is a tool to be used by experienced microbiologists as a basis for advice to product developers and can help to make safety assurance for new food concepts transparent to food inspection services. PMID:15453599

  11. Application of elements of microbiological risk assessment in the food industry via a tiered approach.

    PubMed

    van Gerwen, Suzanne J C; Gorris, Leon G M

    2004-09-01

    Food safety control is a matter for concern for all parts of the food supply chain, including governments that develop food safety policy, food industries that must control potential hazards, and consumers who need to keep to the intended use of the food. In the future, food safety policy may be set using the framework of risk analysis, part of which is the development of (inter)national microbiological risk assessment (MRA) studies. MRA studies increase our understanding of the impact of risk management interventions and of the relationships among subsequent parts of food supply chains with regard to the safety of the food when it reaches the consumer. Application of aspects of MRA in the development of new food concepts has potential benefits for the food industry. A tiered approach to applying MRA can best realize these benefits. The tiered MRA approach involves calculation of microbial fate for a product and process design on the basis of experimental data (e.g., monitoring data on prevalence) and predictive microbiological models. Calculations on new product formulations and novel processing technologies provide improved understanding of microbial fate beyond currently known boundaries, which enables identification of new opportunities in process design. The outcome of the tiered approach focuses on developing benchmarks of potential consumer exposure to hazards associated with new products by comparison with exposure associated with products that are already on the market and have a safe history of use. The tiered prototype is a tool to be used by experienced microbiologists as a basis for advice to product developers and can help to make safety assurance for new food concepts transparent to food inspection services.

  12. 7. Building 7 interior, west end of building showing tier ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Building 7 interior, west end of building showing tier of skylight windows and modern equipment. View looking west. - John & James Dobson Carpet Mill (West Parcel), Building No. 7, 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  13. 4. Interior view to northwest, showing tiers of poles for ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Interior view to northwest, showing tiers of poles for hanging tobacco to cure. - Edgewood Farm, Tobacco Barn, West side of State Route 600, .8 mile north of State Route 778, Clover, Halifax County, VA

  14. Recent development of glacier complex Adygine and resulting risks

    NASA Astrophysics Data System (ADS)

    Falatkova, Kristyna; Sobr, Miroslav; Engel, Zbynek; Jansky, Bohumir

    2015-04-01

    Recent development of glacier complex Adygine and resulting risks Falátková, K., Šobr, M., Engel, Z., Janský, B. Charles University in Prague, Faculty of Science, Prague, Czech republic Glacier complex Adygine (3,400-4,200 m asl) is situated on the northern flank of the Kyrgyz Range, Tien Shan, Kyrgyzstan. The valley downstream is part of National Park Ala Archa, which is popular with tourists, and is heading towards the country's capital - Bishkek. At the study site there is a glacier which is observed since 1960's. The glacier has been monitored by satellite imagery and in last 10 years by on-site geodetic measurement as well. Due to glacier shrinkage several glacial lakes of different genetic types (moraine-dammed, moraine- and rock-dammed, termokarst) have appeared at the site. Nowadays, the lakes are situated on three levels in front of the glacier's terminus and form a cascade, they are also hydrologically connected. The lakes were subjected to detailed bathymetric measurement and some parts of the dams were surveyed by geophysical methods. Especially the newest lakes in proximity of the terminus has been undergoing dynamic changes and may pose a threat in the near future. The risks arising together with changing climatic conditions and retreat of the glacier are associated with mainly three of the lakes. The largest one with area of 3.2 ha is dammed by a rock step overlaid by a moraine. Geophysical research of the dam revealed buried ice and seepage channels in its western part. It is the capacity of these subsurface channels, which are draining the lake throughout the year that represents a weak point in terms of dam stability. The second lake, a termokarst one, is a similar case but drained solely by subsurface channels. Very steep slopes of the lake basin are covered with loose material which could slide down and block the drainage channels. The lake would then fill all the basin (approx. 50,000 m3) very quickly as it is supplied with water from the

  15. Xenoendocrine disrupters-tiered screening and testing: filling key data gaps.

    PubMed

    Gray, L E; Ostby, J; Wilson, V; Lambright, C; Bobseine, K; Hartig, P; Hotchkiss, A; Wolf, C; Furr, J; Price, M; Parks, L; Cooper, R L; Stoker, T E; Laws, S C; Degitz, S J; Jensen, K M; Kahl, M D; Korte, J J; Makynen, E A; Tietge, J E; Ankley, G T

    2002-12-27

    The US Environmental Protection Agency (EPA) is developing a screening and testing program for endocrine disrupting chemicals (EDCs) to detect alterations of hypothalamic-pituitary-gonadal (HPG) function, estrogen (ER), androgen (AR) and thyroid hormone synthesis and AR and ER receptor-mediated effects in mammals and other animals. High priority chemicals would be evaluated in the Tier 1 Screening (T1S) battery and chemicals positive in T1S would then be tested (Tier 2). T1S includes in vitro ER and AR receptor binding and/or gene expression, an assessment of steroidogenesis and mammalian (rat) and nonmammalian in vivo assays (Table 1). In vivo, the uterotropic assay detects estrogens and antiestrogens, while steroidogenesis, antithyroid activity, (anti)estrogenicity and HPG function are assessed in a 'Pubertal Female Assay'. (Anti-) androgens are detected in the Hershberger Assay (weight of AR-dependent tissues in castrate-immature-male rats). Fish and amphibian assays also are being developed. The fathead minnow assay can identify EDCs displaying several mechanisms of concern, including AR and ER receptor agonists and antagonists and inhibitors of steroid hormone synthesis. An amphibian metamorphosis assay is being developed to detect thyroid-active substances. Several alternative mammalian in vivo assays have been proposed. Of these, a short-term pubertal male rat assay appears most promising. An in utero-lactational screening protocol also is being evaluated. For Tier 2, the numbers of endocrine sensitive endpoints and offspring (F1) examined in multigenerational tests need to be expanded for EDCs. Consideration should be given to tailoring T2, based on the results of T1S. Tier 1 and 2 also should examine relevant mixtures of EDCs. Toxicants that induce malformations in AR-dependent tissues produce cumulative effects even when two chemicals act via different mechanisms of action.

  16. Single-Tier Testing with the C6 Peptide ELISA Kit Compared with Two-Tier Testing for Lyme Disease

    PubMed Central

    Wormser, Gary P.; Schriefer, Martin; Aguero-Rosenfeld, Maria E.; Levin, Andrew; Steere, Allen C.; Nadelman, Robert B.; Nowakowski, John; Marques, Adriana; Johnson, Barbara J. B.; Dumler, J. Stephen

    2014-01-01

    Background The two-tier serologic testing protocol for Lyme disease has a number of shortcomings including low sensitivity in early disease; increased cost, time and labor; and subjectivity in the interpretation of immunoblots. Methods The diagnostic accuracy of a single-tier commercial C6 ELISA kit was compared with two-tier testing. Results The C6 ELISA was significantly more sensitive than two-tier testing with sensitivities of 66.5% (95% C.I.:61.7-71.1) and 35.2% (95%C.I.:30.6-40.1), respectively (p<0.001) in 403 sera from patients with erythema migrans. The C6 ELISA had sensitivity statistically comparable to two-tier testing in sera from Lyme disease patients with early neurological manifestations (88.6% vs. 77.3%, p=0.13) or arthritis (98.3% vs. 95.6%, p= 0.38). Te specificities of C6 ELISA and two-tier testing in over 2200 blood donors, patients with other conditions, and Lyme disease vaccine recipients were found to be 98.9% and 99.5%, respectively (p<0.05, 95% C.I. surrounding the 0.6 percentage point difference of 0.04 to 1.15). Conclusions Using a reference standard of two-tier testing, the C6 ELISA as a single step serodiagnostic test provided increased sensitivity in early Lyme disease with comparable sensitivity in later manifestations of Lyme disease. The C6 ELISA had slightly decreased specificity. Future studies should evaluate the performance of the C6 ELISA compared with two-tier testing in routine clinical practice. PMID:23062467

  17. Single-tier testing with the C6 peptide ELISA kit compared with two-tier testing for Lyme disease.

    PubMed

    Wormser, Gary P; Schriefer, Martin; Aguero-Rosenfeld, Maria E; Levin, Andrew; Steere, Allen C; Nadelman, Robert B; Nowakowski, John; Marques, Adriana; Johnson, Barbara J B; Dumler, J Stephen

    2013-01-01

    For the diagnosis of Lyme disease, the 2-tier serologic testing protocol for Lyme disease has a number of shortcomings including low sensitivity in early disease; increased cost, time, and labor; and subjectivity in the interpretation of immunoblots. In this study, the diagnostic accuracy of a single-tier commercial C6 ELISA kit was compared with 2-tier testing. The results showed that the C6 ELISA was significantly more sensitive than 2-tier testing with sensitivities of 66.5% (95% confidence interval [CI] 61.7-71.1) and 35.2% (95% CI 30.6-40.1), respectively (P < 0.001) in 403 sera from patients with erythema migrans. The C6 ELISA had sensitivity statistically comparable to 2-tier testing in sera from Lyme disease patients with early neurologic manifestations (88.6% versus 77.3%, P = 0.13) or arthritis (98.3% versus 95.6%, P = 0.38). The specificities of C6 ELISA and 2-tier testing in over 2200 blood donors, patients with other conditions, and Lyme disease vaccine recipients were found to be 98.9% and 99.5%, respectively (P < 0.05, 95% CI surrounding the 0.6 percentage point difference of 0.04 to 1.15). In conclusion, using a reference standard of 2-tier testing, the C6 ELISA as a single-step serodiagnostic test provided increased sensitivity in early Lyme disease with comparable sensitivity in later manifestations of Lyme disease. The C6 ELISA had slightly decreased specificity. Future studies should evaluate the performance of the C6 ELISA compared with 2-tier testing in routine clinical practice.

  18. Identifying Students for Secondary and Tertiary Prevention Efforts: How Do We Determine Which Students Have Tier 2 and Tier 3 Needs?

    ERIC Educational Resources Information Center

    Lane, Kathleen Lynne; Oakes, Wendy Peia; Ennis, Robin Parks; Hirsch, Shanna Eisner

    2014-01-01

    In comprehensive, integrated, three-tiered models, it is essential to have a systematic method for identifying students who need supports at Tier 2 or Tier 3. This article provides explicit information on how to use multiple sources of data to determine which students might benefit from these supports. First, the authors provide an overview of how…

  19. 40 CFR 86.1860-04 - How to comply with the Tier 2 and interim non-Tier 2 fleet average NOX standards.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... interim non-Tier 2 fleet average NOX standards. 86.1860-04 Section 86.1860-04 Protection of Environment... § 86.1860-04 How to comply with the Tier 2 and interim non-Tier 2 fleet average NOX standards. (a) The fleet average standards referred to in this section are the corporate fleet average standards for...

  20. 40 CFR 86.1861-04 - How do the Tier 2 and interim non-Tier 2 NOX averaging, banking and trading programs work?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 2 NOX averaging, banking and trading programs work? 86.1861-04 Section 86.1861-04 Protection of... Vehicles § 86.1861-04 How do the Tier 2 and interim non-Tier 2 NOX averaging, banking and trading programs... (debits). (c) Early banking. (1)(i) Manufacturers may certify LDV/LLDTs to the Tier 2 FTP...

  1. 40 CFR 86.1861-04 - How do the Tier 2 and interim non-Tier 2 NOX averaging, banking and trading programs work?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 2 NOX averaging, banking and trading programs work? 86.1861-04 Section 86.1861-04 Protection of... Vehicles § 86.1861-04 How do the Tier 2 and interim non-Tier 2 NOX averaging, banking and trading programs... (debits). (c) Early banking. (1)(i) Manufacturers may certify LDV/LLDTs to the Tier 2 FTP...

  2. 40 CFR 86.1861-04 - How do the Tier 2 and interim non-Tier 2 NOX averaging, banking and trading programs work?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 2 NOX averaging, banking and trading programs work? 86.1861-04 Section 86.1861-04 Protection of... § 86.1861-04 How do the Tier 2 and interim non-Tier 2 NOX averaging, banking and trading programs work... (debits). (c) Early banking. (1)(i) Manufacturers may certify LDV/LLDTs to the Tier 2 FTP...

  3. 78 FR 58316 - Complex Issues in Developing Medical Devices for Pediatric Patients Affected by Rare Diseases...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-23

    ... HUMAN SERVICES Food and Drug Administration Complex Issues in Developing Medical Devices for Pediatric... (FDA) is announcing the following public workshop entitled ``Complex Issues in Developing Medical... ``Complex Issues in Developing Drug and Biological Products for Rare Diseases.'' The purpose of the...

  4. Testing a multi-tiered stress-gradient model for risk assessment using sediment constituents from coral reef environments

    USGS Publications Warehouse

    Lidz, B.H.; Hallock, P.; ,

    2000-01-01

    Coral reefs are threatened worldwide by stresses ranging from local to global in extent. One of the major challenges in studies of reef decline is understanding how to distinguish between changes resulting from natural, anthropogenic, local, and global environmental perturbations. As such, a conceptual risk-assessment model is developed that includes tiers for natural stresses, global/regional stresses, and local anthropogenic stresses.

  5. 78 FR 29815 - Control of Air Pollution From Motor Vehicles: Tier 3 Motor Vehicle Emission and Fuel Standards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-21

    ... from inventories developed for the Final Cross-State Air Pollution Rule (76 FR 48208, August 8, 2011... reductions. \\7\\ 65 FR 6698 (February 10, 2000). The proposed Tier 3 standards include new light- and heavy... emissions standards.\\10\\ \\8\\ 77 FR 62623 (October 15, 2012). \\9\\ These states include Connecticut,...

  6. Efficacy of a Tier 2 Supplemental Root Word Vocabulary and Decoding Intervention with Kindergarten Spanish-Speaking English Learners

    ERIC Educational Resources Information Center

    Nelson, J. Ron; Vadasy, Patricia F.; Sanders, Elizabeth A.

    2011-01-01

    The purpose of this study was to test the efficacy of a Tier 2 standard protocol supplemental intervention designed simultaneously to develop root word vocabulary and reinforce decoding skills being taught to all students in the core beginning reading program with kindergarten Spanish-speaking English learners (ELs). Participating students were…

  7. The Etiology of Top-Tier Publications in Management: A Status Attainment Perspective on Academic Career Success

    ERIC Educational Resources Information Center

    Valle, Matthew; Schultz, Kaitlyn

    2011-01-01

    Purpose: The purpose of this paper is to develop and test a comprehensive model of personal and institutional input variables, composed of elements describing status-based antecedents, job/organizational context antecedents, and individual level antecedents, which may contribute to the production of significant (top-tier) research outputs in the…

  8. Multiple drug therapy--a comparative study with 2 tier and 3 tier combination of rifampicin, clofazimine, DDS, INAH and thiacetazone in lepromatous cases.

    PubMed

    Kundu, S K; Ghosh, S; Hazra, S; Chaudhury, S

    1981-04-01

    A comparative study with 2 tier and 3 tier combination of Rifampicin, Clofazimine, DDS, INAH and Thiacetazone was conducted on fifty lepromatous leprosy cases for varying periods. Assessment showed that 2 tier combination of clofazimine and DDS produced good results but the cost stood in the way; whereas 3 tier combination of DDS, thiacetazone and INAH also yielded good results with much less expenses to be incurred by the patients. Whether therapy with this 3 tier combination could be continued for a longer period with sustained improvement is yet to be assessed by further studies for a considerable period.

  9. Evaluating Secondary Students' Scientific Reasoning in Genetics Using a Two-Tier Diagnostic Instrument

    NASA Astrophysics Data System (ADS)

    Tsui, Chi-Yan; Treagust, David

    2010-05-01

    While genetics has remained as one key topic in school science, it continues to be conceptually and linguistically difficult for students with the concomitant debates as to what should be taught in the age of biotechnology. This article documents the development and implementation of a two-tier multiple-choice instrument for diagnosing grades 10 and 12 students' understanding of genetics in terms of reasoning. The pretest and posttest forms of the diagnostic instrument were used alongside other methods in evaluating students' understanding of genetics in a case-based qualitative study on teaching and learning with multiple representations in three Western Australian secondary schools. Previous studies have shown that a two-tier diagnostic instrument is useful in probing students' understanding or misunderstanding of scientific concepts and ideas. The diagnostic instrument in this study was designed and then progressively refined, improved, and implemented to evaluate student understanding of genetics in three case schools. The final version of the instrument had Cronbach's alpha reliability of 0.75 and 0.64, respectively, for its pretest and the posttest forms when it was administered to a group of grade 12 students (n = 17). This two-tier diagnostic instrument complemented other qualitative data collection methods in this research in generating a more holistic picture of student conceptual learning of genetics in terms of scientific reasoning. Implications of the findings of this study using the diagnostic instrument are discussed.

  10. Collusion-Aware Privacy-Preserving Range Query in Tiered Wireless Sensor Networks†

    PubMed Central

    Zhang, Xiaoying; Dong, Lei; Peng, Hui; Chen, Hong; Zhao, Suyun; Li, Cuiping

    2014-01-01

    Wireless sensor networks (WSNs) are indispensable building blocks for the Internet of Things (IoT). With the development of WSNs, privacy issues have drawn more attention. Existing work on the privacy-preserving range query mainly focuses on privacy preservation and integrity verification in two-tiered WSNs in the case of compromised master nodes, but neglects the damage of node collusion. In this paper, we propose a series of collusion-aware privacy-preserving range query protocols in two-tiered WSNs. To the best of our knowledge, this paper is the first to consider collusion attacks for a range query in tiered WSNs while fulfilling the preservation of privacy and integrity. To preserve the privacy of data and queries, we propose a novel encoding scheme to conceal sensitive information. To preserve the integrity of the results, we present a verification scheme using the correlation among data. In addition, two schemes are further presented to improve result accuracy and reduce communication cost. Finally, theoretical analysis and experimental results confirm the efficiency, accuracy and privacy of our proposals. PMID:25615731

  11. Collusion-aware privacy-preserving range query in tiered wireless sensor networks.

    PubMed

    Zhang, Xiaoying; Dong, Lei; Peng, Hui; Chen, Hong; Zhao, Suyun; Li, Cuiping

    2014-12-11

    Wireless sensor networks (WSNs) are indispensable building blocks for the Internet of Things (IoT). With the development of WSNs, privacy issues have drawn more attention. Existing work on the privacy-preserving range query mainly focuses on privacy preservation and integrity verification in two-tiered WSNs in the case of compromisedmaster nodes, but neglects the damage of node collusion. In this paper, we propose a series of collusion-aware privacy-preserving range query protocols in two-tiered WSNs. To the best of our knowledge, this paper is the first to consider collusion attacks for a range query in tiered WSNs while fulfilling the preservation of privacy and integrity. To preserve the privacy of data and queries, we propose a novel encoding scheme to conceal sensitive information. To preserve the integrity of the results, we present a verification scheme using the correlation among data. In addition, two schemes are further presented to improve result accuracy and reduce communication cost. Finally, theoretical analysis and experimental results confirm the efficiency, accuracy and privacy of our proposals.

  12. Collusion-aware privacy-preserving range query in tiered wireless sensor networks.

    PubMed

    Zhang, Xiaoying; Dong, Lei; Peng, Hui; Chen, Hong; Zhao, Suyun; Li, Cuiping

    2014-01-01

    Wireless sensor networks (WSNs) are indispensable building blocks for the Internet of Things (IoT). With the development of WSNs, privacy issues have drawn more attention. Existing work on the privacy-preserving range query mainly focuses on privacy preservation and integrity verification in two-tiered WSNs in the case of compromisedmaster nodes, but neglects the damage of node collusion. In this paper, we propose a series of collusion-aware privacy-preserving range query protocols in two-tiered WSNs. To the best of our knowledge, this paper is the first to consider collusion attacks for a range query in tiered WSNs while fulfilling the preservation of privacy and integrity. To preserve the privacy of data and queries, we propose a novel encoding scheme to conceal sensitive information. To preserve the integrity of the results, we present a verification scheme using the correlation among data. In addition, two schemes are further presented to improve result accuracy and reduce communication cost. Finally, theoretical analysis and experimental results confirm the efficiency, accuracy and privacy of our proposals. PMID:25615731

  13. Health monitoring display system for a complex plant

    DOEpatents

    Ridolfo, Charles F.; Harmon, Daryl L.; Colin, Dreyfuss

    2006-08-08

    A single page enterprise wide level display provides a comprehensive readily understood representation of the overall health status of a complex plant. Color coded failure domains allow rapid intuitive recognition of component failure status. A three-tier hierarchy of displays provide details on the health status of the components and systems displayed on the enterprise wide level display in a manner that supports a logical drill down to the health status of sub-components on Tier 1 to expected faults of the sub-components on Tier 2 to specific information relative to expected sub-component failures on Tier 3.

  14. A tiered analytical approach for investigating poor quality emergency contraceptives.

    PubMed

    Monge, María Eugenia; Dwivedi, Prabha; Zhou, Manshui; Payne, Michael; Harris, Chris; House, Blaine; Juggins, Yvonne; Cizmarik, Peter; Newton, Paul N; Fernández, Facundo M; Jenkins, David

    2014-01-01

    Reproductive health has been deleteriously affected by poor quality medicines. Emergency contraceptive pills (ECPs) are an important birth control method that women can use after unprotected coitus for reducing the risk of pregnancy. In response to the detection of poor quality ECPs commercially available in the Peruvian market we developed a tiered multi-platform analytical strategy. In a survey to assess ECP medicine quality in Peru, 7 out of 25 different batches showed inadequate release of levonorgestrel by dissolution testing or improper amounts of active ingredient. One batch was found to contain a wrong active ingredient, with no detectable levonorgestrel. By combining ultrahigh performance liquid chromatography-ion mobility spectrometry-mass spectrometry (UHPLC-IMS-MS) and direct analysis in real time MS (DART-MS) the unknown compound was identified as the antibiotic sulfamethoxazole. Quantitation by UHPLC-triple quadrupole tandem MS (QqQ-MS/MS) indicated that the wrong ingredient was present in the ECP sample at levels which could have significant physiological effects. Further chemical characterization of the poor quality ECP samples included the identification of the excipients by 2D Diffusion-Ordered Nuclear Magnetic Resonance Spectroscopy (DOSY 1H NMR) indicating the presence of lactose and magnesium stearate. PMID:24748219

  15. A Tiered Analytical Approach for Investigating Poor Quality Emergency Contraceptives

    PubMed Central

    Monge, María Eugenia; Dwivedi, Prabha; Zhou, Manshui; Payne, Michael; Harris, Chris; House, Blaine; Juggins, Yvonne; Cizmarik, Peter; Newton, Paul N.; Fernández, Facundo M.; Jenkins, David

    2014-01-01

    Reproductive health has been deleteriously affected by poor quality medicines. Emergency contraceptive pills (ECPs) are an important birth control method that women can use after unprotected coitus for reducing the risk of pregnancy. In response to the detection of poor quality ECPs commercially available in the Peruvian market we developed a tiered multi-platform analytical strategy. In a survey to assess ECP medicine quality in Peru, 7 out of 25 different batches showed inadequate release of levonorgestrel by dissolution testing or improper amounts of active ingredient. One batch was found to contain a wrong active ingredient, with no detectable levonorgestrel. By combining ultrahigh performance liquid chromatography-ion mobility spectrometry-mass spectrometry (UHPLC-IMS-MS) and direct analysis in real time MS (DART-MS) the unknown compound was identified as the antibiotic sulfamethoxazole. Quantitation by UHPLC-triple quadrupole tandem MS (QqQ-MS/MS) indicated that the wrong ingredient was present in the ECP sample at levels which could have significant physiological effects. Further chemical characterization of the poor quality ECP samples included the identification of the excipients by 2D Diffusion-Ordered Nuclear Magnetic Resonance Spectroscopy (DOSY 1H NMR) indicating the presence of lactose and magnesium stearate. PMID:24748219

  16. Web Service for Positional Quality Assessment: the Wps Tier

    NASA Astrophysics Data System (ADS)

    Xavier, E. M. A.; Ariza-López, F. J.; Ureña-Cámara, M. A.

    2015-08-01

    In the field of spatial data every day we have more and more information available, but we still have little or very little information about the quality of spatial data. We consider that the automation of the spatial data quality assessment is a true need for the geomatic sector, and that automation is possible by means of web processing services (WPS), and the application of specific assessment procedures. In this paper we propose and develop a WPS tier centered on the automation of the positional quality assessment. An experiment using the NSSDA positional accuracy method is presented. The experiment involves the uploading by the client of two datasets (reference and evaluation data). The processing is to determine homologous pairs of points (by distance) and calculate the value of positional accuracy under the NSSDA standard. The process generates a small report that is sent to the client. From our experiment, we reached some conclusions on the advantages and disadvantages of WPSs when applied to the automation of spatial data accuracy assessments.

  17. A tiered analytical approach for investigating poor quality emergency contraceptives.

    PubMed

    Monge, María Eugenia; Dwivedi, Prabha; Zhou, Manshui; Payne, Michael; Harris, Chris; House, Blaine; Juggins, Yvonne; Cizmarik, Peter; Newton, Paul N; Fernández, Facundo M; Jenkins, David

    2014-01-01

    Reproductive health has been deleteriously affected by poor quality medicines. Emergency contraceptive pills (ECPs) are an important birth control method that women can use after unprotected coitus for reducing the risk of pregnancy. In response to the detection of poor quality ECPs commercially available in the Peruvian market we developed a tiered multi-platform analytical strategy. In a survey to assess ECP medicine quality in Peru, 7 out of 25 different batches showed inadequate release of levonorgestrel by dissolution testing or improper amounts of active ingredient. One batch was found to contain a wrong active ingredient, with no detectable levonorgestrel. By combining ultrahigh performance liquid chromatography-ion mobility spectrometry-mass spectrometry (UHPLC-IMS-MS) and direct analysis in real time MS (DART-MS) the unknown compound was identified as the antibiotic sulfamethoxazole. Quantitation by UHPLC-triple quadrupole tandem MS (QqQ-MS/MS) indicated that the wrong ingredient was present in the ECP sample at levels which could have significant physiological effects. Further chemical characterization of the poor quality ECP samples included the identification of the excipients by 2D Diffusion-Ordered Nuclear Magnetic Resonance Spectroscopy (DOSY 1H NMR) indicating the presence of lactose and magnesium stearate.

  18. MITT writer and MITT writer advanced development: Developing authoring and training systems for complex technical domains

    NASA Technical Reports Server (NTRS)

    Wiederholt, Bradley J.; Browning, Elica J.; Norton, Jeffrey E.; Johnson, William B.

    1991-01-01

    MITT Writer is a software system for developing computer based training for complex technical domains. A training system produced by MITT Writer allows a student to learn and practice troubleshooting and diagnostic skills. The MITT (Microcomputer Intelligence for Technical Training) architecture is a reasonable approach to simulation based diagnostic training. MITT delivers training on available computing equipment, delivers challenging training and simulation scenarios, and has economical development and maintenance costs. A 15 month effort was undertaken in which the MITT Writer system was developed. A workshop was also conducted to train instructors in how to use MITT Writer. Earlier versions were used to develop an Intelligent Tutoring System for troubleshooting the Minuteman Missile Message Processing System.

  19. 78 FR 58311 - Complex Issues in Developing Drug and Biological Products for Rare Diseases; Public Workshop...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-23

    ... HUMAN SERVICES Food and Drug Administration Complex Issues in Developing Drug and Biological Products... announcing the following public workshop entitled ``Complex Issues in Developing Drug and Biological Products for Rare Diseases.'' The purpose of the public workshop is twofold: To discuss complex issues...

  20. A tiered approach for the human health risk assessment for consumption of vegetables from with cadmium-contaminated land in urban areas.

    PubMed

    Swartjes, Frank A; Versluijs, Kees W; Otte, Piet F

    2013-10-01

    Consumption of vegetables that are grown in urban areas takes place worldwide. In developing countries, vegetables are traditionally grown in urban areas for cheap food supply. In developing and developed countries, urban gardening is gaining momentum. A problem that arises with urban gardening is the presence of contaminants in soil, which can be taken up by vegetables. In this study, a scientifically-based and practical procedure has been developed for assessing the human health risks from the consumption of vegetables from cadmium-contaminated land. Starting from a contaminated site, the procedure follows a tiered approach which is laid out as follows. In Tier 0, the plausibility of growing vegetables is investigated. In Tier 1 soil concentrations are compared with the human health-based Critical soil concentration. Tier 2 offers the possibility for a detailed site-specific human health risk assessment in which calculated exposure is compared to the toxicological reference dose. In Tier 3, vegetable concentrations are measured and tested following a standardized measurement protocol. To underpin the derivation of the Critical soil concentrations and to develop a tool for site-specific assessment the determination of the representative concentration in vegetables has been evaluated for a range of vegetables. The core of the procedure is based on Freundlich-type plant-soil relations, with the total soil concentration and the soil properties as variables. When a significant plant-soil relation is lacking for a specific vegetable a geometric mean of BioConcentrationFactors (BCF) is used, which is normalized according to soil properties. Subsequently, a 'conservative' vegetable-group-consumption-rate-weighted BioConcentrationFactor is calculated as basis for the Critical soil concentration (Tier 1). The tool to perform site-specific human health risk assessment (Tier 2) includes the calculation of a 'realistic worst case' site-specific vegetable

  1. Modes of tilting during extensional core complex development.

    PubMed

    Coleman, D S; Walker, J D

    1994-01-14

    Crustal extension and formation of the Mineral Mountains core complex, Utah, involved tilting of the Mineral Mountains batholith and associated faults during hanging wall and footwall deformation. The batholith was folded in the hanging wall of the Beaver Valley fault between 11 and 9 million years ago yielding about 45 degrees of tilt. Subsequently, the batholith was unroofed along the Cave Canyon detachment fault, and the batholith and fault were tilted approximately 40 degrees during footwall uplift. Recognition of deformed dikes beneath the detachment fault establishes the importance of footwall tilt during formation of extensional core complexes and demonstrates that footwall rebound can be an important process during extension.

  2. Results of Laboratory Testing of 15 Cookstove Designs in Accordance with the ISO/IWA Tiers of Performance.

    PubMed

    Still, Dean; Bentson, Samuel; Li, Haixi

    2015-03-01

    The widespread adoption and sustained use of modern cookstoves has the potential to reduce harmful effects to climate, health, and the well-being of approximately one-third of the world's population that currently rely on biomass fuel for cooking and heating. In an effort to understand and develop cleaner burning and more efficient cookstoves, 15 stove design and fuel/loading combinations were evaluated in the laboratory using the International Workshop Agreement's five-tiered (0-4) rating system for fuel use and emissions. The designs evaluated include rocket-type combustion chamber models including reduced firepower, sunken pots, and chimneys (three stoves); gasifier-type combustion chambers using prepared fuels in the form of wood pellets (four stoves); forced draft stoves with a small electric fan (five stoves); and a single insulated charcoal stove with preheated secondary air. It was found that a charcoal burning stove was the only stove to meet all the Tier 4 levels of performance. Achieving over 40% thermal efficiency at high power was made possible by reducing firepower and gaps around the pot, although batch-fed stoves generally do not "turn down" for optimal low power performance. While all stoves met Tier 4 for carbon monoxide, only stoves equipped with electrical fans reduced respirable particulate matter to Tier 4 levels. Finally, stoves with chimneys and integrated pots were fuel efficient and virtually eliminated indoor emissions. It is hoped that these design techniques will be useful in further development and evolution of high-performance cookstove designs.

  3. Retrospective on the Seniors' Council Tier 1 LDRD portfolio.

    SciTech Connect

    Ballard, William Parker

    2012-04-01

    This report describes the Tier 1 LDRD portfolio, administered by the Seniors Council between 2003 and 2011. 73 projects were sponsored over the 9 years of the portfolio at a cost of $10.5 million which includes $1.9M of a special effort in directed innovation targeted at climate change and cyber security. Two of these Tier 1 efforts were the seeds for the Grand Challenge LDRDs in Quantum Computing and Next Generation Photovoltaic conversion. A few LDRDs were terminated early when it appeared clear that the research was not going to succeed. A great many more were successful and led to full Tier 2 LDRDs or direct customer sponsorship. Over a dozen patents are in various stages of prosecution from this work, and one project is being submitted for an R and D 100 award.

  4. An evaluation of Access Tier local area network switches.

    SciTech Connect

    Eldridge, John M.; Olsberg, Ronald R.

    2004-06-01

    This reports tabulates the Test and Evaluation results of the Access Class Switch tests conducted by members of Department 9336. About 15 switches were reviewed for use in the enterprise network as access tier switches as defined in a three tier architecture. The Access Switch Tier has several functions including: aggregate customer desktop ports, preserve and apply QoS tags, provide switched LAN access, provide VLAN assignment, as well as others. The typical switch size is 48 or less user ports. The evaluation team reviewed network switch evaluation reports from the Tolly Group as well as other sources. We then used these reports as a starting point to identify particular switches for evaluation. In general we reviewed the products of dominant equipment manufacturers. Also, based on architectural design requirements, the majority of the switches tested were of relatively small monolithic unit variety.

  5. A Cognitive Complexity Metric Applied to Cognitive Development

    ERIC Educational Resources Information Center

    Andrews, Glenda; Halford, Graeme S.

    2002-01-01

    Two experiments tested predictions from a theory in which processing load depends on relational complexity (RC), the number of variables related in a single decision. Tasks from six domains (transitivity, hierarchical classification, class inclusion, cardinality, relative-clause sentence comprehension, and hypothesis testing) were administered to…

  6. The Role of Habitat Complexity in Community Development Is Mediated by Resource Availability

    PubMed Central

    Smith, Rachel S.; Johnston, Emma L.; Clark, Graeme F.

    2014-01-01

    Habitat complexity strongly affects the structure and dynamics of ecological communities, with increased complexity often leading to greater species diversity and abundance. However, habitat complexity changes as communities develop, and some species alter their environment to themselves provide habitat for other species. Most experimental studies manipulate basal substrate complexity, and while the importance of complexity likely changes during community development, few studies have examined the temporal dynamics of this variable. We used two experiments to quantify the importance of basal substrate complexity to sessile marine invertebrate community development through space and time. First, we compared effects of substrate complexity at 70 sites across ten estuaries. Sites differed in recruitment and community development rates, and after three months provided spatial variation in community development stage. Second, we tested for effects of substrate complexity at multiple times at a single site. In both experiments, complexity affected marine sessile invertebrate community composition in the early stages of community development when resource availability was high. Effects of complexity diminished through time as the amount of available space (the primary limiting resource) declined. Our work suggests the presence of a bare-space threshold, at which structural complexity of the basal substrate is overwhelmed by secondary biotic complexity. This threshold will be met at different times depending on local recruitment and growth rates and is likely to vary with productivity gradients. PMID:25054325

  7. [Discussing a "two-tiered medical system": a statement].

    PubMed

    Ehring, F Schulze; Weber, Ch

    2008-12-01

    The criticism of a "two-tiered medical system" is a political slogan, which is also not exactly defined. However, for the public discussion this is not of further importance because talking about a "two-tiered medical system" has a priori a negative impact; in particular in times when people's fears surrounding medical care in Germany are great. Especially in a public health insurance system, insured people worry that in the future they will only receive the most essential medical services, rather than all services that are deemed reasonable and medically appropriate. One of the central themes in the discussion of a "two-tiered medical system" that causes disputes (or animosity) between privately and publicly insured persons arises when comparing differences in waiting periods to see a doctor and additional medical treatments made available to the privately insured. Critics of the "two-tiered medical system" envision a "one-tiered medical system"; one in which every person receives uniform healthcare, and in which the "purchase" of additional medical treatments is not permitted. However, the "one-tiered medical system" remains a theoretical construct. Service differences based on price differences are the reality. So the problem of the "two-tiered medical system" manifests itself only when those services that go beyond the basic care (privately offered services) negatively impact basic care, and/or displace basic care offerings. An example of this would be when a publicly insured patient has to wait longer to see a doctor because preference is given to privately insured patients. Economically speaking, negative external effects come into play. This causality has not been found or proven to be present in the German healthcare system. It exists neither in the inpatient nor in the outpatient healthcare sector. There is no basis to the claim that there is a difference in treatment favouring private patients with detrimental effects to non-privately insured patients

  8. An Analysis of the Factors Influencing the Second Tier and Its Evolution.

    ERIC Educational Resources Information Center

    Reilly, Susan

    1989-01-01

    An analysis of the productivity offsets to achieve second tier wage increases for workers covered by Australian national and Queensland awards shows that the two-tier wage system increased competitiveness and productivity, especially in blue-collar industries. (JOW)

  9. Accelerating the Adoption of Second-Tier Reach Standards forApplicable Appliance Products in China

    SciTech Connect

    Lin, Jiang; Fridley, David

    2007-03-01

    The minimum energy efficiency standards program for household appliances in China was initiated in 1989. Since 1996, CLASP and its implementing partner, LBNL, have assisted China in developing 11 minimum energy performance standards (MEPS) for 9 products and endorsement labels for 11 products including: refrigerators; air conditioners; clothes washers; televisions; printers; computers; monitors; fax machines; copiers; DVD/VCD players; external power supplies; and set-top boxes (under development). Before 2003, China's traditional approach to standards development involved small increases in efficiency requirements for implementation within 6 months of a standard's approval. Since 2003, China has adopted a new approach in setting MEPS. This new approach involves the development of two tiers of standards--one for initial implementation and a second tier at a more aggressive level of energy efficiency for implementation three to five years later. The second-tier standard is also referred to as a 'reach standard'. Reach standards have now been developed in China for: color TVs; refrigerators; air conditioners; and external power supplies. This report is presented in five sections. After the introduction in Section 1, Section 2 analyzes the distribution of the efficiency of refrigerators and air-conditioners in China based on data collected by the China Energy Label Center for the mandatory energy information label program. The results provide an assessment of the adoption of reach standards for these two products. Section 3 summarizes on-going collaborations with Shanghai related to early local adoption of reach standards, and presents both the impact and an analysis of barriers to the local adoption of reach standard for air-conditioners. Section 4 offers suggestions for local governments on how to move forward in adopting reach standards in their localities and concludes with a summary of the results and a plan for developing local capacity in order to achieve

  10. A systems relations model for Tier 2 early intervention child mental health services with schools: an exploratory study.

    PubMed

    van Roosmalen, Marc; Gardner-Elahi, Catherine; Day, Crispin

    2013-01-01

    Over the last 15 years, policy initiatives have aimed at the provision of more comprehensive Child and Adolescent Mental Health care. These presented a series of new challenges in organising and delivering Tier 2 child mental health services, particularly in schools. This exploratory study aimed to examine and clarify the service model underpinning a Tier 2 child mental health service offering school-based mental health work. Using semi-structured interviews, clinician descriptions of operational experiences were gathered. These were analysed using grounded theory methods. Analysis was validated by respondents at two stages. A pathway for casework emerged that included a systemic consultative function, as part of an overall three-function service model, which required: (1) activity as a member of the multi-agency system; (2) activity to improve the system working around a particular child; and (3) activity to universally develop a Tier 1 workforce confident in supporting children at risk of or experiencing mental health problems. The study challenged the perception of such a service serving solely a Tier 2 function, the requisite workforce to deliver the service model, and could give service providers a rationale for negotiating service models that include an explicit focus on improving the children's environments.

  11. Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens

    PubMed Central

    Hessell, Ann J.; Malherbe, Delphine C.; Pissani, Franco; McBurney, Sean; Krebs, Shelly J.; Gomes, Michelle; Pandey, Shilpi; Sutton, William F.; Burwitz, Benjamin J.; Gray, Matthew; Robins, Harlan; Park, Byung S.; Sacha, Jonah B.; LaBranche, Celia C.; Fuller, Deborah H.; Montefiori, David C.; Stamatatos, Leonidas; Sather, D. Noah

    2016-01-01

    Advancement in immunogen selection and vaccine design that will rapidly elicit a protective Ab response is considered critical for HIV vaccine protective efficacy. Vaccine-elicited Ab responses must therefore have the capacity to prevent infection by neutralization-resistant phenotypes of transmitted/founder (T/F) viruses that establish infection in humans. Most vaccine candidates to date have been ineffective at generating Abs that neutralize T/F or early variants. In this study, we report that coimmunizing rhesus macaques with HIV-1 gp160 DNA and gp140 trimeric protein selected from native envelope gene sequences (envs) induced neutralizing Abs against Tier 2 autologous viruses expressing cognate envelope (Env). The Env immunogens were selected from envs emerging during the earliest stages of neutralization breadth developing within the first 2 years of infection in two clade B–infected human subjects. Moreover, the IgG responses in macaques emulated the targeting to specific regions of Env known to be associated with autologous and heterologous neutralizing Abs developed within the human subjects. Furthermore, we measured increasing affinity of macaque polyclonal IgG responses over the course of the immunization regimen that correlated with Tier 1 neutralization. In addition, we report firm correlations between Tier 2 autologous neutralization and Tier 1 heterologous neutralization, as well as overall TZM-bl breadth scores. Additionally, the activation of Env-specific follicular helper CD4 T cells in lymphocytes isolated from inguinal lymph nodes of vaccinated macaques correlated with Tier 2 autologous neutralization. These results demonstrate the potential for native Env derived from subjects at the time of neutralization broadening as effective HIV vaccine elements. PMID:26944928

  12. Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens.

    PubMed

    Hessell, Ann J; Malherbe, Delphine C; Pissani, Franco; McBurney, Sean; Krebs, Shelly J; Gomes, Michelle; Pandey, Shilpi; Sutton, William F; Burwitz, Benjamin J; Gray, Matthew; Robins, Harlan; Park, Byung S; Sacha, Jonah B; LaBranche, Celia C; Fuller, Deborah H; Montefiori, David C; Stamatatos, Leonidas; Sather, D Noah; Haigwood, Nancy L

    2016-04-01

    Advancement in immunogen selection and vaccine design that will rapidly elicit a protective Ab response is considered critical for HIV vaccine protective efficacy. Vaccine-elicited Ab responses must therefore have the capacity to prevent infection by neutralization-resistant phenotypes of transmitted/founder (T/F) viruses that establish infection in humans. Most vaccine candidates to date have been ineffective at generating Abs that neutralize T/F or early variants. In this study, we report that coimmunizing rhesus macaques with HIV-1 gp160 DNA and gp140 trimeric protein selected from native envelope gene sequences (envs) induced neutralizing Abs against Tier 2 autologous viruses expressing cognate envelope (Env). The Env immunogens were selected from envs emerging during the earliest stages of neutralization breadth developing within the first 2 years of infection in two clade B-infected human subjects. Moreover, the IgG responses in macaques emulated the targeting to specific regions of Env known to be associated with autologous and heterologous neutralizing Abs developed within the human subjects. Furthermore, we measured increasing affinity of macaque polyclonal IgG responses over the course of the immunization regimen that correlated with Tier 1 neutralization. In addition, we report firm correlations between Tier 2 autologous neutralization and Tier 1 heterologous neutralization, as well as overall TZM-bl breadth scores. Additionally, the activation of Env-specific follicular helper CD4 T cells in lymphocytes isolated from inguinal lymph nodes of vaccinated macaques correlated with Tier 2 autologous neutralization. These results demonstrate the potential for native Env derived from subjects at the time of neutralization broadening as effective HIV vaccine elements. PMID:26944928

  13. Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens.

    PubMed

    Hessell, Ann J; Malherbe, Delphine C; Pissani, Franco; McBurney, Sean; Krebs, Shelly J; Gomes, Michelle; Pandey, Shilpi; Sutton, William F; Burwitz, Benjamin J; Gray, Matthew; Robins, Harlan; Park, Byung S; Sacha, Jonah B; LaBranche, Celia C; Fuller, Deborah H; Montefiori, David C; Stamatatos, Leonidas; Sather, D Noah; Haigwood, Nancy L

    2016-04-01

    Advancement in immunogen selection and vaccine design that will rapidly elicit a protective Ab response is considered critical for HIV vaccine protective efficacy. Vaccine-elicited Ab responses must therefore have the capacity to prevent infection by neutralization-resistant phenotypes of transmitted/founder (T/F) viruses that establish infection in humans. Most vaccine candidates to date have been ineffective at generating Abs that neutralize T/F or early variants. In this study, we report that coimmunizing rhesus macaques with HIV-1 gp160 DNA and gp140 trimeric protein selected from native envelope gene sequences (envs) induced neutralizing Abs against Tier 2 autologous viruses expressing cognate envelope (Env). The Env immunogens were selected from envs emerging during the earliest stages of neutralization breadth developing within the first 2 years of infection in two clade B-infected human subjects. Moreover, the IgG responses in macaques emulated the targeting to specific regions of Env known to be associated with autologous and heterologous neutralizing Abs developed within the human subjects. Furthermore, we measured increasing affinity of macaque polyclonal IgG responses over the course of the immunization regimen that correlated with Tier 1 neutralization. In addition, we report firm correlations between Tier 2 autologous neutralization and Tier 1 heterologous neutralization, as well as overall TZM-bl breadth scores. Additionally, the activation of Env-specific follicular helper CD4 T cells in lymphocytes isolated from inguinal lymph nodes of vaccinated macaques correlated with Tier 2 autologous neutralization. These results demonstrate the potential for native Env derived from subjects at the time of neutralization broadening as effective HIV vaccine elements.

  14. Effects of Tier 3 Intervention for Students with Persistent Reading Difficulties and Characteristics of Inadequate Responders

    ERIC Educational Resources Information Center

    Denton, Carolyn A.; Tolar, Tammy D.; Fletcher, Jack M.; Barth, Amy E.; Vaughn, Sharon; Francis, David J.

    2013-01-01

    This article describes a randomized controlled trial conducted to evaluate the effects of an intensive, individualized, Tier 3 reading intervention for second grade students who had previously experienced inadequate response to quality first grade classroom reading instruction (Tier 1) and supplemental small-group intervention (Tier 2). Also…

  15. 40 CFR 81.131 - Southern Tier West Intrastate Air Quality Control Region.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Southern Tier West Intrastate Air... Air Quality Control Regions § 81.131 Southern Tier West Intrastate Air Quality Control Region. The Southern Tier West Intrastate Air Quality Control Region (New York) consists of the territorial...

  16. Understanding Inadequate Response to First-Grade Multi-Tier Intervention: Nomothetic and Ideographic Perspectives

    ERIC Educational Resources Information Center

    Greulich, Luana; Al Otaiba, Stephanie; Schatschneider, Christopher; Wanzek, Jeanne; Ortiz, Miriam; Wagner, Richard K.

    2014-01-01

    The purpose of this study was to use a mixed methods approach to learn about inadequate response to a year-long multi-tier response to intervention (RTI) model that allowed first-grade students to move up and down tiers. Participants were 156 students who received supplemental intervention services during a larger multi-tier RTI study involving…

  17. Use of Self-Monitoring to Maintain Program Fidelity of Multi-Tiered Interventions

    ERIC Educational Resources Information Center

    Nelson, J. Ron; Oliver, Regina M.; Hebert, Michael A.; Bohaty, Janet

    2015-01-01

    Multi-tiered system of supports represents one of the most significant advancements in improving the outcomes of students for whom typical instruction is not effective. While many practices need to be in place to make multi-tiered systems of support effective, accurate implementation of evidence-based practices by individuals at all tiers is…

  18. 40 CFR 370.41 - What is Tier I inventory information?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... categories are defined in 40 CFR 370.66. Tier I information includes all of the following: (a) Certification... 40 Protection of Environment 27 2010-07-01 2010-07-01 false What is Tier I inventory information...-KNOW Reporting Requirements How to Comply with Inventory Reporting § 370.41 What is Tier I...

  19. 40 CFR 370.41 - What is Tier I inventory information?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... categories are defined in 40 CFR 370.66. Tier I information includes all of the following: (a) Certification... categories are defined in 40 CFR 370.66. Tier I inventory form includes the following data elements: (a... information contained in the Tier I form. (q) The name, title, phone number and email address of at least...

  20. 40 CFR 370.41 - What is Tier I inventory information?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... categories are defined in 40 CFR 370.66. Tier I inventory form includes the following data elements: (a... information contained in the Tier I form. (q) The name, title, phone number and email address of at least one... 40 Protection of Environment 28 2014-07-01 2014-07-01 false What is Tier I inventory...

  1. 21 CFR 1404.435 - What must I require of a primary tier participant?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 9 2011-04-01 2011-04-01 false What must I require of a primary tier participant... Officials Regarding Transactions § 1404.435 What must I require of a primary tier participant? You as an agency official must require each participant in a primary tier covered transaction to— (a) Comply...

  2. 25 CFR 542.30 - What is a Tier B gaming operation?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false What is a Tier B gaming operation? 542.30 Section 542.30 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS § 542.30 What is a Tier B gaming operation? A Tier B gaming operation is one with...

  3. 25 CFR 542.20 - What is a Tier A gaming operation?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false What is a Tier A gaming operation? 542.20 Section 542.20 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS § 542.20 What is a Tier A gaming operation? A Tier A gaming operation is one with...

  4. 25 CFR 542.40 - What is a Tier C gaming operation?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false What is a Tier C gaming operation? 542.40 Section 542.40 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS § 542.40 What is a Tier C gaming operation? A Tier C gaming operation is one with...

  5. 25 CFR 542.40 - What is a Tier C gaming operation?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What is a Tier C gaming operation? 542.40 Section 542.40 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS § 542.40 What is a Tier C gaming operation? A Tier C gaming operation is one with...

  6. 25 CFR 542.30 - What is a Tier B gaming operation?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What is a Tier B gaming operation? 542.30 Section 542.30 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS § 542.30 What is a Tier B gaming operation? A Tier B gaming operation is one with...

  7. 25 CFR 542.20 - What is a Tier A gaming operation?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What is a Tier A gaming operation? 542.20 Section 542.20 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS § 542.20 What is a Tier A gaming operation? A Tier A gaming operation is one with...

  8. Complexity, Chaos, and Nonlinear Dynamics: A New Perspective on Career Development Theory

    ERIC Educational Resources Information Center

    Bloch, Deborah P.

    2005-01-01

    The author presents a theory of career development drawing on nonlinear dynamics and chaos and complexity theories. Career is presented as a complex adaptive entity, a fractal of the human entity. Characteristics of complex adaptive entities, including (a) autopiesis, or self-regeneration; (b) open exchange; (c) participation in networks; (d)…

  9. 26 CFR 1.444-2T - Tiered structure (temporary).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... this section, B is a partner in two partnerships, B1 and B2. B1 and B2 are deferral entities, as... member of a tiered structure unless B's aggregate ownership interests in B1 and B2 are considered...

  10. 26 CFR 1.444-2T - Tiered structure (temporary).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... this section, B is a partner in two partnerships, B1 and B2. B1 and B2 are deferral entities, as... member of a tiered structure unless B's aggregate ownership interests in B1 and B2 are considered...

  11. 26 CFR 1.444-2T - Tiered structure (temporary).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... this section, B is a partner in two partnerships, B1 and B2. B1 and B2 are deferral entities, as... member of a tiered structure unless B's aggregate ownership interests in B1 and B2 are considered...

  12. 26 CFR 1.444-2T - Tiered structure (temporary).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... this section, B is a partner in two partnerships, B1 and B2. B1 and B2 are deferral entities, as... member of a tiered structure unless B's aggregate ownership interests in B1 and B2 are considered...

  13. 26 CFR 1.444-2T - Tiered structure (temporary).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... this section, B is a partner in two partnerships, B1 and B2. B1 and B2 are deferral entities, as... member of a tiered structure unless B's aggregate ownership interests in B1 and B2 are considered...

  14. 50 CFR 86.53 - What are funding tiers?

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 9 2012-10-01 2012-10-01 false What are funding tiers? 86.53 Section 86.53 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT...

  15. 50 CFR 86.53 - What are funding tiers?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false What are funding tiers? 86.53 Section 86.53 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT...

  16. 50 CFR 86.53 - What are funding tiers?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false What are funding tiers? 86.53 Section 86.53 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR (CONTINUED) FINANCIAL ASSISTANCE-WILDLIFE SPORT FISH RESTORATION PROGRAM BOATING INFRASTRUCTURE GRANT...

  17. A Collaborative Planning Framework for Teachers Implementing Tiered Instruction

    ERIC Educational Resources Information Center

    Stuart, Shannon K.; Rinaldi, Claudia

    2009-01-01

    The recent reauthorization and regulations of the Individuals With Disabilities Education Improvement Act (IDEA 2004) encourage the use of school-wide interventions including response to intervention (RTI; Bradley, Danielson, & Doolittle, 2007). RTI refers to a multi-tiered system that addresses the academic needs of all students by using…

  18. Teaching Borges's "Garden": A Three-Tiered Approach.

    ERIC Educational Resources Information Center

    Christensen, Maggie

    2002-01-01

    Describes how "The Garden of Forking Paths" presents teaching challenges that ultimately yield benefits worth the effort for students and instructors. Discusses a three-tiered approach: spy story, family history and character, and ideas of time and timelessness. Concludes that the three layers provide a structure to get the discussion started and…

  19. Lessons Learned from a Tiered Service Delivery Implementation Project

    ERIC Educational Resources Information Center

    Johnson, Evelyn S.; Pool, Juli L.; Carter, Deborah R.

    2012-01-01

    Tiered models of service delivery for both academics and behavior are being increasingly adopted across the nation, and discussions of how to implement these models effectively and simultaneously are growing. In this article, the authors share some lessons learned from a 2-year implementation project to implement a comprehensive (both academic and…

  20. 46 CFR 356.9 - Tiered ownership structures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false Tiered ownership structures. 356.9 Section 356.9 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION MISCELLANEOUS REQUIREMENTS FOR VESSELS OF 100 FEET OR GREATER IN REGISTERED LENGTH TO OBTAIN A FISHERY ENDORSEMENT TO THE VESSEL'S...

  1. 46 CFR 356.9 - Tiered ownership structures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Tiered ownership structures. 356.9 Section 356.9 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION MISCELLANEOUS REQUIREMENTS FOR VESSELS OF 100 FEET OR GREATER IN REGISTERED LENGTH TO OBTAIN A FISHERY ENDORSEMENT TO THE VESSEL'S...

  2. 46 CFR 356.9 - Tiered ownership structures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Tiered ownership structures. 356.9 Section 356.9 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION MISCELLANEOUS REQUIREMENTS FOR VESSELS OF 100 FEET OR GREATER IN REGISTERED LENGTH TO OBTAIN A FISHERY ENDORSEMENT TO THE VESSEL'S...

  3. 46 CFR 356.9 - Tiered ownership structures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Tiered ownership structures. 356.9 Section 356.9 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION MISCELLANEOUS REQUIREMENTS FOR VESSELS OF 100 FEET OR GREATER IN REGISTERED LENGTH TO OBTAIN A FISHERY ENDORSEMENT TO THE VESSEL'S...

  4. 46 CFR 356.9 - Tiered ownership structures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Tiered ownership structures. 356.9 Section 356.9 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION MISCELLANEOUS REQUIREMENTS FOR VESSELS OF 100 FEET OR GREATER IN REGISTERED LENGTH TO OBTAIN A FISHERY ENDORSEMENT TO THE VESSEL'S...

  5. Mindfulness Practice: A Tier 1 Response to Intervention Strategy

    ERIC Educational Resources Information Center

    Lindsay-Simmons, Stacey A.

    2011-01-01

    Response to Intervention (RTI) is gaining ground. However, using RTI to assess the needs of students with behavioral problems is in its early stages. Teachers have limited tools at their disposal to use as Tier 1 strategies, such as classroom management strategies, or maybe a social skills curriculum taught once a week for 30 minutes. Research on…

  6. Patch diameter limits for tiered subaperture SAR image formation algorithms

    SciTech Connect

    Doerry, A.W.

    1994-12-31

    Synthetic Aperture Radar image formation algorithms typically use transform techniques that often requires trading between image resolution, algorithm efficiency, and focussed image scene size limits. This is due to assumptions for the data such as simplified (often straight-line) flight paths, simplified imaging geometry, and simplified models for phase functions. Many errors in such assumptions are typically untreatable due to their dependence on both data domain positions and image domain positions. The result is that large scenes often require inefficient multiple image formation iterations, followed by a mosaicking operation of the focussed image patches. One class of image formation algorithms that performs favorably divides the spatial and frequency apertures into subapertures, and perhaps those subapertures into sub-subapertures, and so on, in a tiered subaperture fashion. This allows a gradual shift from data domain into image domain that allows correcting many types of errors that limit other image formation algorithms, even in a dynamic motion environment, thereby allowing larger focussed image patches without mosaicking. This paper presents and compares focussed patch diameter limits for tiered subaperture (TSA) image formation algorithms, for various numbers of tiers of subapertures. Examples are given that show orders-of-magnitude improvement in non-mosaicked focussed image patch size over traditional polar format processing, and that patch size limits increase with the number of tiers of subapertures, although with diminishing returns.

  7. Three-Tiered Models of Prevention: Teacher Efficacy and Burnout

    ERIC Educational Resources Information Center

    Oakes, Wendy Peia; Lane, Kathleen Lynne; Jenkins, Abbie; Booker, Belle B.

    2013-01-01

    Project Persevere examined teacher efficacy and burnout within Comprehensive, Integrated, Three-tiered (CI3T) models of prevention, as implemented in two middle schools in a southern state. Participating schools completed a year-long training series to design their CI3T plans and were in their first year of implementation as part of regular school…

  8. Benchmarking Tier-One Universities: "Keeping up with the Joneses"

    ERIC Educational Resources Information Center

    Valcik, Nicolas A.; Scruton, Kimberly E.; Murchison, Stuart B.; Benavides, Ted J.; Jordan, Todd; Stigdon, Andrea D.; Olszewski, Angela M.

    2012-01-01

    The purpose of this research is to analyze the attributes of top-tier public institutions and their host municipalities to determine if there are common factors in how the organizations are structured, how they interact, and whether a symbiotic relationship exists that can benefit both entities. This research attempted to determine if cities under…

  9. 10. INTERIOR OF OUTLET TOWER LOOKING DOWN TO TIER #1 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. INTERIOR OF OUTLET TOWER LOOKING DOWN TO TIER #1 OF SLIDE GATES. STRUCTURE HAS LEVELS ENABLING OPERATORS TO CHOOSE LEVEL WITH BEST QUALITY WATER. OVERHANGING DEVICE THAT LOOKS LIKE A LIGHT STANDARD IS ACTUALLY A METER FOR MEASURING WATER LEVELS. - Lake Mathews, East of Route 15, Riverside, Riverside County, CA

  10. 47 CFR 76.920 - Composition of the basic tier.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Composition of the basic tier. 76.920 Section 76.920 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Cable Rate Regulation § 76.920 Composition of the basic...

  11. 47 CFR 76.920 - Composition of the basic tier.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Composition of the basic tier. 76.920 Section 76.920 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Cable Rate Regulation § 76.920 Composition of the basic...

  12. 47 CFR 76.920 - Composition of the basic tier.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Composition of the basic tier. 76.920 Section 76.920 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Cable Rate Regulation § 76.920 Composition of the basic...

  13. 47 CFR 76.920 - Composition of the basic tier.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 4 2013-10-01 2013-10-01 false Composition of the basic tier. 76.920 Section 76.920 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Cable Rate Regulation § 76.920 Composition of the basic...

  14. 47 CFR 76.920 - Composition of the basic tier.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 4 2014-10-01 2014-10-01 false Composition of the basic tier. 76.920 Section 76.920 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Cable Rate Regulation § 76.920 Composition of the basic...

  15. Tier III Assessments, Data-Based Decision Making, and Interventions

    ERIC Educational Resources Information Center

    Powers, Kristin; Mandal, Arpita

    2011-01-01

    Within the Response-to-Intervention framework, students who fail to profit from high-quality general education instruction, accommodations, and supplemental instruction progress to a more intensive intervention program, sometimes referred to as "Tier III." This article describes a problem-solving approach to designing such intensive, data-based,…

  16. Multi-Tier Mental Health Program for Refugee Youth

    ERIC Educational Resources Information Center

    Ellis, B. Heidi; Miller, Alisa B.; Abdi, Saida; Barrett, Colleen; Blood, Emily A.; Betancourt, Theresa S.

    2013-01-01

    Objective: We sought to establish that refugee youths who receive a multi-tiered approach to services, Project SHIFA, would show high levels of engagement in treatment appropriate to their level of mental health distress, improvements in mental health symptoms, and a decrease in resource hardships. Method: Study participants were 30 Somali and…

  17. General Education Assessment Plan: A Four-Tiered Approach

    ERIC Educational Resources Information Center

    McLawhon, Ryan; Phillips, Loraine H.

    2013-01-01

    Planning is possibly the most important step of the assessment process. This article presents a four-tiered approach to designing and implementing a general education institutional assessment plan. Categorizing the measures you use to assess established learning outcomes helps you prioritize your general education assessment initiatives and keep…

  18. Effective medical leadership development for a complex NHS.

    PubMed

    Edmonstone, John; Malby, Rebecca

    2014-08-01

    The NHS Leadership Academy in England is investing £46 million in a standardized model of development, with academic qualifications becoming essential in future NHS leadership roles. This represents a cul-de-sac for medical leaders because it is based on a series of misplaced assumptions about health-care leadership and its development.

  19. Pooling the resources of the CMS Tier-1 sites

    DOE PAGES

    Apyan, A.; Badillo, J.; Cruz, J. Diaz; Gadrat, S.; Gutsche, O.; Holzman, B.; Lahiff, A.; Magini, N.; Mason, D.; Perez, A.; et al

    2015-12-23

    The CMS experiment at the LHC relies on 7 Tier-1 centres of the WLCG to perform the majority of its bulk processing activity, and to archive its data. During the first run of the LHC, these two functions were tightly coupled as each Tier-1 was constrained to process only the data archived on its hierarchical storage. This lack of flexibility in the assignment of processing workflows occasionally resulted in uneven resource utilisation and in an increased latency in the delivery of the results to the physics community.The long shutdown of the LHC in 2013-2014 was an opportunity to revisit thismore » mode of operations, disentangling the processing and archive functionalities of the Tier-1 centres. The storage services at the Tier-1s were redeployed breaking the traditional hierarchical model: each site now provides a large disk storage to host input and output data for processing, and an independent tape storage used exclusively for archiving. Movement of data between the tape and disk endpoints is not automated, but triggered externally through the WLCG transfer management systems.With this new setup, CMS operations actively controls at any time which data is available on disk for processing and which data should be sent to archive. Thanks to the high-bandwidth connectivity guaranteed by the LHCOPN, input data can be freely transferred between disk endpoints as needed to take advantage of free CPU, turning the Tier-1s into a large pool of shared resources. The output data can be validated before archiving them permanently, and temporary data formats can be produced without wasting valuable tape resources. Lastly, the data hosted on disk at Tier-1s can now be made available also for user analysis since there is no risk any longer of triggering chaotic staging from tape.In this contribution, we describe the technical solutions adopted for the new disk and tape endpoints at the sites, and we report on the commissioning and scale testing of the service. We detail the

  20. Pooling the resources of the CMS Tier-1 sites

    SciTech Connect

    Apyan, A.; Badillo, J.; Cruz, J. Diaz; Gadrat, S.; Gutsche, O.; Holzman, B.; Lahiff, A.; Magini, N.; Mason, D.; Perez, A.; Stober, F.; Taneja, S.; Taze, M.; Wissing, C.

    2015-12-23

    The CMS experiment at the LHC relies on 7 Tier-1 centres of the WLCG to perform the majority of its bulk processing activity, and to archive its data. During the first run of the LHC, these two functions were tightly coupled as each Tier-1 was constrained to process only the data archived on its hierarchical storage. This lack of flexibility in the assignment of processing workflows occasionally resulted in uneven resource utilisation and in an increased latency in the delivery of the results to the physics community.The long shutdown of the LHC in 2013-2014 was an opportunity to revisit this mode of operations, disentangling the processing and archive functionalities of the Tier-1 centres. The storage services at the Tier-1s were redeployed breaking the traditional hierarchical model: each site now provides a large disk storage to host input and output data for processing, and an independent tape storage used exclusively for archiving. Movement of data between the tape and disk endpoints is not automated, but triggered externally through the WLCG transfer management systems.With this new setup, CMS operations actively controls at any time which data is available on disk for processing and which data should be sent to archive. Thanks to the high-bandwidth connectivity guaranteed by the LHCOPN, input data can be freely transferred between disk endpoints as needed to take advantage of free CPU, turning the Tier-1s into a large pool of shared resources. The output data can be validated before archiving them permanently, and temporary data formats can be produced without wasting valuable tape resources. Lastly, the data hosted on disk at Tier-1s can now be made available also for user analysis since there is no risk any longer of triggering chaotic staging from tape.In this contribution, we describe the technical solutions adopted for the new disk and tape endpoints at the sites, and we report on the commissioning and scale testing of the service. We detail the

  1. Pooling the resources of the CMS Tier-1 sites

    NASA Astrophysics Data System (ADS)

    Apyan, A.; Badillo, J.; Diaz Cruz, J.; Gadrat, S.; Gutsche, O.; Holzman, B.; Lahiff, A.; Magini, N.; Mason, D.; Perez, A.; Stober, F.; Taneja, S.; Taze, M.; Wissing, C.

    2015-12-01

    The CMS experiment at the LHC relies on 7 Tier-1 centres of the WLCG to perform the majority of its bulk processing activity, and to archive its data. During the first run of the LHC, these two functions were tightly coupled as each Tier-1 was constrained to process only the data archived on its hierarchical storage. This lack of flexibility in the assignment of processing workflows occasionally resulted in uneven resource utilisation and in an increased latency in the delivery of the results to the physics community. The long shutdown of the LHC in 2013-2014 was an opportunity to revisit this mode of operations, disentangling the processing and archive functionalities of the Tier-1 centres. The storage services at the Tier-1s were redeployed breaking the traditional hierarchical model: each site now provides a large disk storage to host input and output data for processing, and an independent tape storage used exclusively for archiving. Movement of data between the tape and disk endpoints is not automated, but triggered externally through the WLCG transfer management systems. With this new setup, CMS operations actively controls at any time which data is available on disk for processing and which data should be sent to archive. Thanks to the high-bandwidth connectivity guaranteed by the LHCOPN, input data can be freely transferred between disk endpoints as needed to take advantage of free CPU, turning the Tier-1s into a large pool of shared resources. The output data can be validated before archiving them permanently, and temporary data formats can be produced without wasting valuable tape resources. Finally, the data hosted on disk at Tier-1s can now be made available also for user analysis since there is no risk any longer of triggering chaotic staging from tape. In this contribution, we describe the technical solutions adopted for the new disk and tape endpoints at the sites, and we report on the commissioning and scale testing of the service. We detail the

  2. 40 CFR 86.1860-04 - How to comply with the Tier 2 and interim non-Tier 2 fleet average NOX standards.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... exhaust NOX emissions set forth in: § 86.1811-04(d) for Tier 2 LDV/Ts and MDPVs (0.07 g/mi); § 86.1811-04(l)(3) for interim non-Tier 2 LDV/LLDTs (0.30 g/mi); and, § 86.1811-04(l)(3) for interim non-Tier 2... average NOX standard for the required phase-in percentage for that year as specified in §...

  3. 40 CFR 86.1860-04 - How to comply with the Tier 2 and interim non-Tier 2 fleet average NOX standards.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... exhaust NOX emissions set forth in: § 86.1811-04(d) for Tier 2 LDV/Ts and MDPVs (0.07 g/mi); § 86.1811-04(l)(3) for interim non-Tier 2 LDV/LLDTs (0.30 g/mi); and, § 86.1811-04(l)(3) for interim non-Tier 2... average NOX standard for the required phase-in percentage for that year as specified in §...

  4. 40 CFR 86.1860-04 - How to comply with the Tier 2 and interim non-Tier 2 fleet average NOX standards.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... exhaust NOX emissions set forth in: § 86.1811-04(d) for Tier 2 LDV/Ts and MDPVs (0.07 g/mi); § 86.1811-04(l)(3) for interim non-Tier 2 LDV/LLDTs (0.30 g/mi); and, § 86.1811-04(l)(3) for interim non-Tier 2... average NOX standard for the required phase-in percentage for that year as specified in §...

  5. Initial recommendations for higher-tier risk assessment protocols for bumble bees, Bombus spp. (Hymenoptera: Apidae).

    PubMed

    Cabrera, Ana R; Almanza, Maria Teresa; Cutler, G Christopher; Fischer, David L; Hinarejos, Silvia; Lewis, Gavin; Nigro, Daniel; Olmstead, Allen; Overmyer, Jay; Potter, Daniel A; Raine, Nigel E; Stanley-Stahr, Cory; Thompson, Helen; van der Steen, Jozef

    2016-04-01

    Global declines of bumble bees and other pollinator populations are of concern because of their critical role for crop production and maintenance of wild plant biodiversity. Although the consensus among scientists is that the interaction of many factors, including habitat loss, forage scarcity, diseases, parasites, and pesticides, potentially plays a role in causing these declines, pesticides have received considerable attention and scrutiny. In response, regulatory agencies have introduced more stringent pollinator testing requirements for registration and reregistration of pesticides, to ensure that the risks to pollinators are minimized. In this context, guidelines for testing bumble bees (Bombus spp.) in regulatory studies are not yet available, and a pressing need exists to develop suitable protocols for routine higher-tier studies with these non-Apis sp., social bees. To meet this need, Bayer CropScience LP, Syngenta Crop Protection LLC US, and Valent USA. Corporation organized a workshop bringing together a group of global experts on bumble bee behavior, ecology, and ecotoxicology to discuss and develop draft protocols for both semi-field (Tier II) and field (Tier III) studies. The workshop was held May 8-9, 2014, at the Bayer Bee Care Center, North Carolina, USA. The participants represented academic, consulting, and industry scientists from Europe, Canada, the United States, and Brazil. The workshop identified a clear protection goal and generated proposals for basic experimental designs, relevant measurements, and endpoints for both semifield (tunnel) and field tests. These initial recommendations are intended to form the basis of discussions to help advance the development of appropriate protocol guidelines.

  6. Development of a complex compound chill storage system

    SciTech Connect

    Rockenfelleer, U.; Kirol, L.

    1991-08-01

    A thermal energy storage system applicable to industrial refrigeration needs at temperatures as low as {minus}28{degree}C has been developed. The system is based on the chemical bonding between a gaseous refrigerant and a solid salt. The system has been tested successfully in the laboratory and a small unit capable of holding 4 ton-h has been constructed in a factory environment. Much of the development efforts have centered on designing the reactor/heat exchanger where the salt and the refrigerant are combined. Economic evaluations have been made and show an estimated simple rate of return between 30 and 50%. 6 refs., 30 figs.

  7. Developing shape analysis tools to assist complex spatial decision making

    SciTech Connect

    Mackey, H.E.; Ehler, G.B.; Cowen, D.

    1996-05-31

    The objective of this research was to develop and implement a shape identification measure within a geographic information system, specifically one that incorporates analytical modeling for site location planning. The application that was developed incorporated a location model within a raster-based GIS, which helped address critical performance issues for the decision support system. Binary matrices, which approximate the object`s geometrical form, are passed over the grided data structure and allow identification of irregular and regularly shaped objects. Lastly, the issue of shape rotation is addressed and is resolved by constructing unique matrices corresponding to the object`s orientation

  8. Plant senescence. A complex lesson of biology of development.

    PubMed

    Pennazio, Sergio

    2009-01-01

    Plant senescence has represented a mystery of biology since 1961, when Carl Leopold sensed the main factors that might control it. The discovery of several hormonal classes gave a precious aid to understand the first mechanisms regulating the phenomenon, which was, in particular, studied in leaf. After the discovery of the molecular bases of genetics, several specialists attempted to connect the hormone activity with the molecular genetic work but only during the 1990s, after the discovery of specific senescence-associate genes, the role of promoting-senescence hormones and retarding-senescence hormones was in good part elucidated, with the help of the plant species Arabidopsis thaliana and its mutants. The history of leaf senescence has had its paradigmatic model in the chlorophyll degradation, a process that remained itself a mystery until 1991, when the products of degradation began being isolated and chemically identified. The research into plant senescence is still the objective of specialists, and represents a very complex problem the integration of which in a unique system appears to be yet far.

  9. An optimization of the ALICE XRootD storage cluster at the Tier-2 site in Czech Republic

    NASA Astrophysics Data System (ADS)

    Adamova, D.; Horky, J.

    2012-12-01

    ALICE, as well as the other experiments at the CERN LHC, has been building a distributed data management infrastructure since 2002. Experience gained during years of operations with different types of storage managers deployed over this infrastructure has shown, that the most adequate storage solution for ALICE is the native XRootD manager developed within a CERN - SLAC collaboration. The XRootD storage clusters exhibit higher stability and availability in comparison with other storage solutions and demonstrate a number of other advantages, like support of high speed WAN data access or no need for maintaining complex databases. Two of the operational characteristics of XRootD data servers are a relatively high number of open sockets and a high Unix load. In this article, we would like to describe our experience with the tuning/optimization of machines hosting the XRootD servers, which are part of the ALICE storage cluster at the Tier-2 WLCG site in Prague, Czech Republic. The optimization procedure, in addition to boosting the read/write performance of the servers, also resulted in a reduction of the Unix load.

  10. Hospital tiers in health insurance: balancing consumer choice with financial incentives.

    PubMed

    Robinson, James C

    2003-01-01

    Variations in efficiency and market power are generating wide variations in the prices charged by hospitals to health insurance plans. Insurers are developing new network structures that expose the consumer to some of the cost differences, to encourage but not mandate differential use of the more economical facilities. The three leading designs include hospital "tiers" within a single broad network, multiple-network products, and the replacement of copayments by coinsurance in HMO as well as PPO products. This paper describes the new network designs and evaluates the challenges they face in influencing consumers' behavior, incorporating information on clinical quality, and supporting medical education and uncompensated care. PMID:14527246

  11. The Development of Second Language Writing Complexity in Groups and Individuals: A Longitudinal Learner Corpus Study

    ERIC Educational Resources Information Center

    Vyatkina, Nina

    2012-01-01

    This study explores the development of multiple dimensions of linguistic complexity in the writing of beginning learners of German both as a group and as individuals. The data come from an annotated, longitudinal learner corpus. The development of lexicogrammatical complexity is explored at 2 intersections: (a) between cross-sectional trendlines…

  12. Dynamic Development of Complexity and Accuracy: A Case Study in Second Language Academic Writing

    ERIC Educational Resources Information Center

    Rosmawati

    2014-01-01

    This paper reports on the development of complexity and accuracy in English as a Second Language (ESL) academic writing. Although research into complexity and accuracy development in second language (L2) writing has been well established, few studies have assumed the multidimensionality of these two constructs (Norris & Ortega, 2009) or…

  13. Developing integrated methods to address complex resource and environmental issues

    USGS Publications Warehouse

    Smith, Kathleen S.; Phillips, Jeffrey D.; McCafferty, Anne E.; Clark, Roger N.

    2016-02-08

    IntroductionThis circular provides an overview of selected activities that were conducted within the U.S. Geological Survey (USGS) Integrated Methods Development Project, an interdisciplinary project designed to develop new tools and conduct innovative research requiring integration of geologic, geophysical, geochemical, and remote-sensing expertise. The project was supported by the USGS Mineral Resources Program, and its products and acquired capabilities have broad applications to missions throughout the USGS and beyond.In addressing challenges associated with understanding the location, quantity, and quality of mineral resources, and in investigating the potential environmental consequences of resource development, a number of field and laboratory capabilities and interpretative methodologies evolved from the project that have applications to traditional resource studies as well as to studies related to ecosystem health, human health, disaster and hazard assessment, and planetary science. New or improved tools and research findings developed within the project have been applied to other projects and activities. Specifically, geophysical equipment and techniques have been applied to a variety of traditional and nontraditional mineral- and energy-resource studies, military applications, environmental investigations, and applied research activities that involve climate change, mapping techniques, and monitoring capabilities. Diverse applied geochemistry activities provide a process-level understanding of the mobility, chemical speciation, and bioavailability of elements, particularly metals and metalloids, in a variety of environmental settings. Imaging spectroscopy capabilities maintained and developed within the project have been applied to traditional resource studies as well as to studies related to ecosystem health, human health, disaster assessment, and planetary science. Brief descriptions of capabilities and laboratory facilities and summaries of some

  14. Developing integrated methods to address complex resource and environmental issues

    USGS Publications Warehouse

    Smith, Kathleen S.; Phillips, Jeffrey D.; McCafferty, Anne E.; Clark, Roger N.

    2016-02-08

    IntroductionThis circular provides an overview of selected activities that were conducted within the U.S. Geological Survey (USGS) Integrated Methods Development Project, an interdisciplinary project designed to develop new tools and conduct innovative research requiring integration of geologic, geophysical, geochemical, and remote-sensing expertise. The project was supported by the USGS Mineral Resources Program, and its products and acquired capabilities have broad applications to missions throughout the USGS and beyond.In addressing challenges associated with understanding the location, quantity, and quality of mineral resources, and in investigating the potential environmental consequences of resource development, a number of field and laboratory capabilities and interpretative methodologies evolved from the project that have applications to traditional resource studies as well as to studies related to ecosystem health, human health, disaster and hazard assessment, and planetary science. New or improved tools and research findings developed within the project have been applied to other projects and activities. Specifically, geophysical equipment and techniques have been applied to a variety of traditional and nontraditional mineral- and energy-resource studies, military applications, environmental investigations, and applied research activities that involve climate change, mapping techniques, and monitoring capabilities. Diverse applied geochemistry activities provide a process-level understanding of the mobility, chemical speciation, and bioavailability of elements, particularly metals and metalloids, in a variety of environmental settings. Imaging spectroscopy capabilities maintained and developed within the project have been applied to traditional resource studies as well as to studies related to ecosystem health, human health, disaster assessment, and planetary science. Brief descriptions of capabilities and laboratory facilities and summaries of some

  15. Structural development of the western Makran Accretionary Complex, Offshore Iran

    NASA Astrophysics Data System (ADS)

    Burberry, C. M.; Jackson, C. A.

    2013-12-01

    The Makran Accretionary Complex (MAC), which straddles the southern offshore regions of Iran and Pakistan, is a fold-thrust system bound by the Murray Ridge and Ornach Nal Fault to the east, and the Minab Fault System (MFS) to the west. It is c. 1000 km wide and the frontal c. 125 km of the system is submerged beneath the Gulf of Oman. Relatively little is known about this system, despite the fact that constitutes a large portion of the Central Tethyan Orogen and is one of the largest accretionary complexes in the world. We use offshore 2D seismic reflection data to investigate the structural style and evolution of the Iranian segment of the MAC. The MAC is divided into two morphologically distinct domains: (i) a northern domain (Domain 1), which is located landward of a prominant break-in-slope on the seabed and is characterised by a series of normal fault-bound sub-basins that are approximately 50 km wide, and which contain numerous, unconformity-bound seismic units; and (ii) a southern domain (Domain 2), which is located basinward of the prominent seabed slope break, and is characterised by alternating ridges and troughs. Seismic data indicate that these structures are laterally continuous (over 100 km long) north-dipping thrust faults, which are overlain by south-verging, non-cylindrical, fault-propagation folds. Towards the western end of the study area, immediately offshore of the prominent onshore trace of the MFS, there is no single structure that can be reliably interpreted as the offshore extension of the MFS. Instead, a series of oblique-slip faults with thrust and strike-slip components are identified, spanning a zone that is c. 40 km wide. In the north and close to the coastline, the faults are dominantly strike-slip, whereas further south, closer to the deformation front, the thrust-sense component is more important. Irrespective of their slip sense, faults in this zone have a similar N-S strike to the onshore trace of the MFS. In addition, the basin

  16. Dusty (complex) plasmas: recent developments, advances, and unsolved problems

    NASA Astrophysics Data System (ADS)

    Popel, Sergey

    The area of dusty (complex) plasma research is a vibrant subfield of plasma physics that be-longs to frontier research in physical sciences. This area is intrinsically interdisciplinary and encompasses astrophysics, planetary science, atmospheric science, magnetic fusion energy sci-ence, and various applied technologies. The research in dusty plasma started after two major discoveries in very different areas: (1) the discovery by the Voyager 2 spacecraft in 1980 of the radial spokes in Saturn's B ring, and (2) the discovery of the early 80's growth of contaminating dust particles in plasma processing. Dusty plasmas are ubiquitous in the universe; examples are proto-planetary and solar nebulae, molecular clouds, supernovae explosions, interplanetary medium, circumsolar rings, and asteroids. Within the solar system, we have planetary rings (e.g., Saturn and Jupiter), Martian atmosphere, cometary tails and comae, dust clouds on the Moon, etc. Close to the Earth, there are noctilucent clouds and polar mesospheric summer echoes, which are clouds of tiny (charged) ice particles that are formed in the summer polar mesosphere at the altitudes of about 82-95 km. Dust and dusty plasmas are also found in the vicinity of artificial satellites and space stations. Dust also turns out to be common in labo-ratory plasmas, such as in the processing of semiconductors and in tokamaks. In processing plasmas, dust particles are actually grown in the discharge from the reactive gases used to form the plasmas. An example of the relevance of industrial dusty plasmas is the growth of silicon microcrystals for improved solar cells in the future. In fact, nanostructured polymorphous sili-con films provide solar cells with high and time stable efficiency. These nano-materials can also be used for the fabrication of ultra-large-scale integration circuits, display devices, single elec-tron devices, light emitting diodes, laser diodes, and others. In microelectronic industries, dust has to be

  17. Getting prepared for the LHC Run2: the PIC Tier-1 case

    NASA Astrophysics Data System (ADS)

    Flix, J.; Acción, E.; Acín, V.; Acosta, C.; Casals, J.; Caubet, M.; Cruz, R.; Delfino, M.; López, F.; Pacheco, A.; Pérez-Calero Yzquierdo, A.; Planas, E.; Porto, M.; Rodríguez, B.; Sedov, A.

    2015-12-01

    The Large Hadron Collider (LHC) experiments will collect unprecedented data volumes in the next Physics run, with high pile-up collisions resulting in events that require a complex processing. Hence, the collaborations have been required to update their Computing Models to optimize the use of the available resources and control the growth of resources, in the midst of widespread funding restrictions, without penalizing any of the Physics objectives. The changes in computing for Run2 represent significant efforts for the collaborations, as well as significant repercussions on how the WLCG sites are built and operated. This paper focuses on these changes, and how they have been implemented and integrated in the Spanish WLCG Tier-1 centre at Port d'Informació Cientifica (PIC), which serves the ATLAS, CMS and LHCb experiments. The approach to adapt a multi-VO site to the new requirements, while maintaining top reliability levels for all the experiments, is as well presented. Additionally, a description of work done to reduce the operational and maintenance costs of the Spanish Tier-1 centre, in agreement with the expectations from WLCG, is provided.

  18. Epigenetic regulation by BAF (mSWI/SNF) chromatin remodeling complexes is indispensable for embryonic development.

    PubMed

    Nguyen, Huong; Sokpor, Godwin; Pham, Linh; Rosenbusch, Joachim; Stoykova, Anastassia; Staiger, Jochen F; Tuoc, Tran

    2016-05-18

    The multi-subunit chromatin-remodeling SWI/SNF (known as BAF for Brg/Brm-associated factor) complexes play essential roles in development. Studies have shown that the loss of individual BAF subunits often affects local chromatin structure and specific transcriptional programs. However, we do not fully understand how BAF complexes function in development because no animal mutant had been engineered to lack entire multi-subunit BAF complexes. Importantly, we recently reported that double conditional knock-out (dcKO) of the BAF155 and BAF170 core subunits in mice abolished the presence of the other BAF subunits in the developing cortex. The generated dcKO mutant provides a novel and powerful tool for investigating how entire BAF complexes affect cortical development. Using this model, we found that BAF complexes globally control the key heterochromatin marks, H3K27me2 and -3, by directly modulating the enzymatic activity of the H3K27 demethylases, Utx and Jmjd3. Here, we present further insights into how the scaffolding ability of the BAF155 and BAF170 core subunits maintains the stability of BAF complexes in the forebrain and throughout the embryo during development. Furthermore, we show that the loss of BAF complexes in the above-described model up-regulates H3K27me3 and impairs forebrain development and embryogenesis. These findings improve our understanding of epigenetic mechanisms and their modulation by the chromatin-remodeling SWI/SNF complexes that control embryonic development.

  19. Building Tier 3 Intervention for Long-Term Slow Growers in Grades 3-4: A Pilot Study

    ERIC Educational Resources Information Center

    Sanchez, Victoria M.; O'Connor, Rollanda E.

    2015-01-01

    Tier 3 interventions are necessary for improving the reading performance of students who fail to respond adequately to Tier 1 general education instruction and Tier 2 supplemental reading intervention. In this pilot study, we identified 8 students in 3rd and 4th grade who had demonstrated slow response to Tier 2 reading interventions for three…

  20. DEVELOPMENT OF A COMPLEX MULTIPLE SCHEDULE IN THE CHIMPANZEE.

    PubMed

    BELLEVILLE, R E; ROHLES, F H; GRUNZKE, M E; CLARK, F C

    1963-10-01

    The development of chimpanzee behavior on a four-component, three-lever multiple schedule is described. Component schedules included the Sidman avoidance procedure with a concurrent discriminated avoidance schedule on a second lever, fixed ratio performance for food, differential reinforcement of low rate for water requiring a dual response chain, and a symbol discrimination task for continuous food reinforcement using three levers. The avoidance component of this schedule was employed during the January 31, 1961 suborbital space flight of the chimpanzee "Ham." On November 29, 1961, the chimpanzee "Enos" performed on the multiple schedule during three orbits around the earth in a Mercury capsule.

  1. Big Data, Global Development, and Complex Social Systems

    NASA Astrophysics Data System (ADS)

    Eagle, Nathan

    2010-03-01

    Petabytes of data about human movements, transactions, and communication patterns are continuously being generated by everyday technologies such as mobile phones and credit cards. This unprecedented volume of information facilitates a novel set of research questions applicable to a wide range of development issues. In collaboration with the mobile phone, internet, and credit card industries, my colleagues and I are aggregating and analyzing behavioral data from over 250 million people from North and South America, Europe, Asia and Africa. I will discuss a selection of projects arising from these collaborations that involve inferring behavioral dynamics on a broad spectrum of scales; from risky behavior in a group of MIT freshman to population-level behavioral signatures, including cholera outbreaks in Rwanda and wealth in the UK. Access to the movement patterns of the majority of mobile phones in East Africa also facilitates realistic models of disease transmission as well as slum formations. This vast volume of data requires new analytical tools - we are developing a range of large-scale network analysis and machine learning algorithms that we hope will provide deeper insight into human behavior. However, ultimately our goal is to determine how we can use these insights to actively improve the lives of the billions of people who generate this data and the societies in which they live.

  2. Testing SLURM open source batch system for a Tierl/Tier2 HEP computing facility

    NASA Astrophysics Data System (ADS)

    Donvito, Giacinto; Salomoni, Davide; Italiano, Alessandro

    2014-06-01

    In this work the testing activities that were carried on to verify if the SLURM batch system could be used as the production batch system of a typical Tier1/Tier2 HEP computing center are shown. SLURM (Simple Linux Utility for Resource Management) is an Open Source batch system developed mainly by the Lawrence Livermore National Laboratory, SchedMD, Linux NetworX, Hewlett-Packard, and Groupe Bull. Testing was focused both on verifying the functionalities of the batch system and the performance that SLURM is able to offer. We first describe our initial set of requirements. Functionally, we started configuring SLURM so that it replicates all the scheduling policies already used in production in the computing centers involved in the test, i.e. INFN-Bari and the INFN-Tier1 at CNAF, Bologna. Currently, the INFN-Tier1 is using IBM LSF (Load Sharing Facility), while INFN-Bari, an LHC Tier2 for both CMS and Alice, is using Torque as resource manager and MAUI as scheduler. We show how we configured SLURM in order to enable several scheduling functionalities such as Hierarchical FairShare, Quality of Service, user-based and group-based priority, limits on the number of jobs per user/group/queue, job age scheduling, job size scheduling, and scheduling of consumable resources. We then show how different job typologies, like serial, MPI, multi-thread, whole-node and interactive jobs can be managed. Tests on the use of ACLs on queues or in general other resources are then described. A peculiar SLURM feature we also verified is triggers on event, useful to configure specific actions on each possible event in the batch system. We also tested highly available configurations for the master node. This feature is of paramount importance since a mandatory requirement in our scenarios is to have a working farm cluster even in case of hardware failure of the server(s) hosting the batch system. Among our requirements there is also the possibility to deal with pre-execution and post

  3. Gravitational effects on structure development in quenched complex fluids.

    PubMed

    Badalassi, V E; Ceniceros, H D; Banerjee, S

    2004-11-01

    When binary liquid mixtures are cooled rapidly from a homogeneous phase into a two-phase system, domains of the two equilibrium phases form and grow (coarsen) with time. In the absence of an external forcing due to gravity or an imposed shear flow, a dynamic scaling regime emerges in which the domain morphology is statistically self-similar at different times with a length-scale that grows with time. In the presence of gravity, however, multiple length scales develop, with the system coarsening more rapidly in the direction of the force. The late-time behavior of such a system is characterized in this study by the calculation of anisotropic growth laws. Gravitation effects significantly affect scaling laws, even with small density mismatch, and the growth mechanism has some similarities to the sedimentation process. However, very few numerical studies have been made of such effects; this is one of the first. PMID:15644369

  4. The development and application of composite complexity models and a relative complexity metric in a software maintenance environment

    NASA Technical Reports Server (NTRS)

    Hops, J. M.; Sherif, J. S.

    1994-01-01

    A great deal of effort is now being devoted to the study, analysis, prediction, and minimization of software maintenance expected cost, long before software is delivered to users or customers. It has been estimated that, on the average, the effort spent on software maintenance is as costly as the effort spent on all other software costs. Software design methods should be the starting point to aid in alleviating the problems of software maintenance complexity and high costs. Two aspects of maintenance deserve attention: (1) protocols for locating and rectifying defects, and for ensuring that noe new defects are introduced in the development phase of the software process; and (2) protocols for modification, enhancement, and upgrading. This article focuses primarily on the second aspect, the development of protocols to help increase the quality and reduce the costs associated with modifications, enhancements, and upgrades of existing software. This study developed parsimonious models and a relative complexity metric for complexity measurement of software that were used to rank the modules in the system relative to one another. Some success was achieved in using the models and the relative metric to identify maintenance-prone modules.

  5. Control of the taeniosis/cysticercosis complex: future developments.

    PubMed

    Flisser, Ana; Rodríguez-Canul, Rossanna; Willingham, Arve Lee

    2006-07-31

    Cysticercosis is due to the establishment of the larval stage of the zoonotic cestode parasite Taenia solium. The infection causes substantial human morbidity and mortality, particularly in several Latin American countries and parts of Africa and Asia, as well as economic losses in pig husban dry due to condemnation of infected pork meat. The life cycle of T. solium includes human beings as definitive hosts and pigs as intermediate hosts. Cysticercosis is acquired by the ingestion of eggs released by human tapeworm carriers, who become infected after ingesting pork meat contaminated with cysticerci. Taenia solium transmission has been associated with poverty, lack of sanitary services and practices of rearing backyard pigs with free access to the areas that villagers use as toilets, as well as cultural behaviour. Nonetheless, due to the recent increase of migration and tourism, industrial countries are also reporting cases of human cysticercosis. There are many epidemiological studies that have been conducted mainly in Latin American countries that have evaluated intervention measures for control of cysticercosis including the development and testing of vaccines. Furthermore, the involvement of international agencies and institutions, such as the World Health Organization, the Food and Agriculture Organization and the International Livestock Research Institute, as well as the commitment of policymakers, scientists and field workers, are key means for the sustainable control and, hopefully, eradication of T. solium infections.

  6. Development of a knowledge management system for complex domains.

    PubMed

    Perott, André; Schader, Nils; Bruder, Ralph; Leonhardt, Jörg

    2012-01-01

    Deutsche Flugsicherung GmbH, the German Air Navigation Service Provider, follows a systematic approach, called HERA, for investigating incidents. The HERA analysis shows a distinctive occurrence of incidents in German air traffic control in which the visual perception of information plays a key role. The reasons can be partially traced back to workstation design, where basic ergonomic rules and principles are not sufficiently followed by the designers in some cases. In cooperation with the Institute of Ergonomics in Darmstadt the DFS investigated possible approaches that may support designers to implement ergonomic systems. None of the currently available tools were found to be able to meet the identified user requirements holistically. Therefore it was suggested to develop an enhanced software tool called Design Process Guide. The name Design Process Guide indicates that this tool exceeds the classic functions of currently available Knowledge Management Systems. It offers "design element" based access, shows processual and content related topics, and shows the implications of certain design decisions. Furthermore, it serves as documentation, detailing why a designer made to a decision under a particular set of conditions.

  7. Development of a knowledge management system for complex domains.

    PubMed

    Perott, André; Schader, Nils; Bruder, Ralph; Leonhardt, Jörg

    2012-01-01

    Deutsche Flugsicherung GmbH, the German Air Navigation Service Provider, follows a systematic approach, called HERA, for investigating incidents. The HERA analysis shows a distinctive occurrence of incidents in German air traffic control in which the visual perception of information plays a key role. The reasons can be partially traced back to workstation design, where basic ergonomic rules and principles are not sufficiently followed by the designers in some cases. In cooperation with the Institute of Ergonomics in Darmstadt the DFS investigated possible approaches that may support designers to implement ergonomic systems. None of the currently available tools were found to be able to meet the identified user requirements holistically. Therefore it was suggested to develop an enhanced software tool called Design Process Guide. The name Design Process Guide indicates that this tool exceeds the classic functions of currently available Knowledge Management Systems. It offers "design element" based access, shows processual and content related topics, and shows the implications of certain design decisions. Furthermore, it serves as documentation, detailing why a designer made to a decision under a particular set of conditions. PMID:22317137

  8. The Complex Trauma Questionnaire (ComplexTQ): development and preliminary psychometric properties of an instrument for measuring early relational trauma

    PubMed Central

    Maggiora Vergano, Carola; Lauriola, Marco; Speranza, Anna M.

    2015-01-01

    Research on the etiology of adult psychopathology and its relationship with childhood trauma has focused primarily on specific forms of maltreatment. This study developed an instrument for the assessment of childhood and adolescence trauma that would aid in identifying the role of co-occurring childhood stressors and chronic adverse conditions. The Complex Trauma Questionnaire (ComplexTQ), in both clinician and self-report versions, is a measure for the assessment of multi-type maltreatment: physical, psychological, and sexual abuse; physical and emotional neglect as well as other traumatic experiences, such rejection, role reversal, witnessing domestic violence, separations, and losses. The four-point Likert scale allows to specifically indicate with which caregiver the traumatic experience has occurred. A total of 229 participants, a sample of 79 nonclinical and that of 150 high-risk and clinical participants, were assessed with the ComplexTQ clinician version applied to Adult Attachment Interview (AAI) transcripts. Initial analyses indicate acceptable inter-rater reliability. A good fit to a 6-factor model regarding the experience with the mother and to a 5-factor model with the experience with the father was obtained; the internal consistency of factors derived was good. Convergent validity was provided with the AAI scales. ComplexTQ factors discriminated normative from high-risk and clinical samples. The findings suggest a promising, reliable, and valid measurement of early relational trauma that is reported; furthermore, it is easy to complete and is useful for both research and clinical practice. PMID:26388820

  9. Mechanical seal having a double-tier mating ring

    DOEpatents

    Khonsari, Michael M.; Somanchi, Anoop K.

    2005-09-13

    An apparatus and method to enhance the overall performance of mechanical seals in one of the following ways: by reducing seal face wear, by reducing the contact surface temperature, or by increasing the life span of mechanical seals. The apparatus is a mechanical seal (e.g., single mechanical seals, double mechanical seals, tandem mechanical seals, bellows, pusher mechanical seals, and all types of rotating and reciprocating machines) comprising a rotating ring and a double-tier mating ring. In a preferred embodiment, the double-tier mating ring comprises a first and a second stationary ring that together form an agitation-inducing, guided flow channel to allow for the removal of heat generated at the seal face of the mating ring by channeling a coolant entering the mating ring to a position adjacent to and in close proximity with the interior surface area of the seal face of the mating ring.

  10. Development of Morphosyntactic Accuracy and Grammatical Complexity in Dutch School-Age Children with SLI

    ERIC Educational Resources Information Center

    Zwitserlood, Rob; van Weerdenburg, Marjolijn; Verhoeven, Ludo; Wijnen, Frank

    2015-01-01

    Purpose: The purpose of this study was to identify the development of morphosyntactic accuracy and grammatical complexity in Dutch school-age children with specific language impairment (SLI). Method: Morphosyntactic accuracy, the use of dummy auxiliaries, and complex syntax were assessed using a narrative task that was administered at three points…

  11. Navigating Complex Trade-Offs in Conservation and Development: An Integrative Framework

    ERIC Educational Resources Information Center

    Hirsch, Paul D.; Brosius, J. Peter

    2013-01-01

    We present a framework that makes space for multiple perspectives and ways of thinking about complex trade-off problems in conservation and development. At the core of the framework are three "integrative lenses" designed to facilitate lines of inquiry according to three unique ways of perceiving complexity. The aim of the framework is…

  12. Dynamics of Complexity and Accuracy: A Longitudinal Case Study of Advanced Untutored Development

    ERIC Educational Resources Information Center

    Polat, Brittany; Kim, Youjin

    2014-01-01

    This longitudinal case study follows a dynamic systems approach to investigate an under-studied research area in second language acquisition, the development of complexity and accuracy for an advanced untutored learner of English. Using the analytical tools of dynamic systems theory (Verspoor et al. 2011) within the framework of complexity,…

  13. Guidelines and Recommendations for Developing Interactive eHealth Apps for Complex Messaging in Health Promotion

    PubMed Central

    Heffernan, Kayla Joanne; Maclean, Skye Tamara; Callegari, Emma Teresa; Garland, Suzanne Marie; Reavley, Nicola Jane; Varigos, George Andrew; Wark, John Dennis

    2016-01-01

    Background The now ubiquitous catchphrase, “There’s an app for that,” rings true owing to the growing number of mobile phone apps. In excess of 97,000 eHealth apps are available in major app stores. Yet the effectiveness of these apps varies greatly. While a minority of apps are developed grounded in theory and in conjunction with health care experts, the vast majority are not. This is concerning given the Hippocratic notion of “do no harm.” There is currently no unified formal theory for developing interactive eHealth apps, and development is especially difficult when complex messaging is required, such as in health promotion and prevention. Objective This paper aims to provide insight into the creation of interactive eHealth apps for complex messaging, by leveraging the Safe-D case study, which involved complex messaging required to guide safe but sufficient UV exposure for vitamin D synthesis in users. We aim to create recommendations for developing interactive eHealth apps for complex messages based on the lessons learned during Safe-D app development. Methods For this case study we developed an Apple and Android app, both named Safe-D, to safely improve vitamin D status in young women through encouraging safe ultraviolet radiation exposure. The app was developed through participatory action research involving medical and human computer interaction researchers, subject matter expert clinicians, external developers, and target users. The recommendations for development were created from analysis of the development process. Results By working with clinicians and implementing disparate design examples from the literature, we developed the Safe-D app. From this development process, recommendations for developing interactive eHealth apps for complex messaging were created: (1) involve a multidisciplinary team in the development process, (2) manage complex messages to engage users, and (3) design for interactivity (tailor recommendations, remove barriers to

  14. Simulation of streamflow in the McTier Creek watershed, South Carolina

    USGS Publications Warehouse

    Feaster, Toby D.; Golden, Heather E.; Odom, Kenneth R.; Lowery, Mark A.; Conrads, Paul A.; Bradley, Paul M.

    2010-01-01

    of model-fit efficiency index, Pearson's correlation coefficient, the root mean square error, the bias, and the mean absolute error. In addition, a number of graphical tools were used to assess how well the models captured the characteristics of the observed data at the Monetta and New Holland streamflow-gaging stations. The graphical tools included temporal plots of simulated and observed daily mean flows, flow-duration curves, single-mass curves, and various residual plots. The results indicated that TOPMODEL and GBMM generally produced simulations that reasonably capture the quantity, variability, and timing of the observed streamflow. For the periods modeled, the total volume of simulated daily mean flows as compared to the total volume of the observed daily mean flow from TOPMODEL was within 1 to 5 percent, and the total volume from GBMM was within 1 to 10 percent. A noticeable characteristic of the simulated hydrographs from both models is the complexity of balancing groundwater recession and flow at the streamgage when flows peak and recede rapidly. However, GBMM results indicate that groundwater recession, which affects the receding limb of the hydrograph, was more difficult to estimate with the spatially explicit curve number approach. Although the purpose of this report is not to directly compare both models, given the characteristics of the McTier Creek watershed and the fact that GBMM uses the spatially explicit curve number approach as compared to the variable-source-area concept in TOPMODEL, GBMM was able to capture the flow characteristics reasonably well.

  15. Home energy rating system building energy simulation test (HERS BESTEST): Volume 1, Tier 1 and Tier 2 tests user's manual

    SciTech Connect

    Judkoff, R.; Neymark, J.

    1995-11-01

    The Home Energy Rating System (HERS) Building Energy Simulation Test (BESTEST) is a method for evaluating the credibility of software used by HERS to model energy use in buildings. The method provides the technical foundation for ''certification of the technical accuracy of building energy analysis tools used to determine energy efficiency ratings,'' as called for in the Energy Policy Act of 1992 (Title I, subtitle A,l Section 102, Title II, Part 6, Section 271). Certification is accomplished with a uniform set of test cases that facilitate the comparison of a software tool with several of the best public-domain, state-of-the-art building energy simulation programs available in the United States. This set of test cases represents the Tier 1 and Tier 2 Tests for Certification of Rating Tools as described in DOE 10 CFR Part 437 and the HERS Council Guidelines for Uniformity (HERS Council). A third Tier of tests not included in this document is also planned.

  16. Transcriptome complexity in cardiac development and diseases--an expanding universe between genome and phenome.

    PubMed

    Gao, Chen; Wang, Yibin

    2014-01-01

    With the advancement of transcriptome profiling by micro-arrays and high-throughput RNA-sequencing, transcriptome complexity and its dynamics are revealed at different levels in cardiovascular development and diseases. In this review, we will highlight the recent progress in our knowledge of cardiovascular transcriptome complexity contributed by RNA splicing, RNA editing and noncoding RNAs. The emerging importance of many of these previously under-explored aspects of gene regulation in cardiovascular development and pathology will be discussed.

  17. Environmental issues related to mineral development in the Stillwater Complex, Mt. Information Circular/1985

    SciTech Connect

    Nigbor, M.T.; Iverson, S.R.; Hyndman, P.C.

    1985-01-01

    This Bureau of Mines publication identifies the significant environmental issues associated with the potential development of strategic and critical minerals in the Stillwater Complex, MT. The Stillwater Complex contains deposits of Cr, platinum-group metals (PGM), and Ni. Issues that must be addressed prior to minerals development include the effects mining, milling, and smelting will have on the land, water, and air, and methods of minimizing the environmental impacts.

  18. Development as a Complex Process of Change: Conception and Analysis of Projects, Programs and Policies

    ERIC Educational Resources Information Center

    Nordtveit, Bjorn Harald

    2010-01-01

    Development is often understood as a linear process of change towards Western modernity, a vision that is challenged by this paper, arguing that development efforts should rather be connected to the local stakeholders' sense of their own development. Further, the paper contends that Complexity Theory is more effective than a linear theory of…

  19. The Use of Complexity Theory and Strange Attractors to Understand and Explain Information System Development

    ERIC Educational Resources Information Center

    Tomasino, Arthur P.

    2013-01-01

    In spite of the best efforts of researchers and practitioners, Information Systems (IS) developers are having problems "getting it right". IS developments are challenged by the emergence of unanticipated IS characteristics undermining managers ability to predict and manage IS change. Because IS are complex, development formulas, best…

  20. Response of Stream Macroinvertebrate Assemblages to Nutrients Within the Tiered Aquatic Life Use (TALU) Framework.

    NASA Astrophysics Data System (ADS)

    Back, J. A.; King, R. S.

    2005-05-01

    The US EPA's Tiered Aquatic Life Use (TALU) conceptual model uses narrative biological attributes to assign water bodies to tiers of biological condition. The model assumes that different types of biological attributes respond to increasing ecosystem degradation in a predictable manner. However, little empirical work has been done to evaluate whether attributes respond to specific types of stressors, such as nutrients, as predicted by the model. Thus, we evaluated the response of macroinvertebrate assemblage attributes to soluble reactive phosphorus (SRP) concentrations along a steep, longitudinal phosphorus gradient in the North Bosque River in central Texas. Consistent with the model, some attributes indicative of high biological integrity (e.g., percent intolerant taxa, percent EPT taxa) decreased with increasing SRP concentration. Similarly, some attribute values associated with poor conditions increased with increasing SRP concentrations. However, taxa richness peaked at intermediate SRP concentrations. Moreover, feeding group attributes, indicators of functional changes, showed no consistent pattern along the gradient. These results suggest that many of the theoretical responses to disturbance predicted by the TALU model may apply to nutrients in streams, but others may need additional scrutiny. They also demonstrate that macroinvertebrate assemblages may be useful in the development of numerical nutrient criteria.

  1. Web mapping system for complex processing and visualization of environmental geospatial datasets

    NASA Astrophysics Data System (ADS)

    Titov, Alexander; Gordov, Evgeny; Okladnikov, Igor

    2016-04-01

    Environmental geospatial datasets (meteorological observations, modeling and reanalysis results, etc.) are used in numerous research applications. Due to a number of objective reasons such as inherent heterogeneity of environmental datasets, big dataset volume, complexity of data models used, syntactic and semantic differences that complicate creation and use of unified terminology, the development of environmental geodata access, processing and visualization services as well as client applications turns out to be quite a sophisticated task. According to general INSPIRE requirements to data visualization geoportal web applications have to provide such standard functionality as data overview, image navigation, scrolling, scaling and graphical overlay, displaying map legends and corresponding metadata information. It should be noted that modern web mapping systems as integrated geoportal applications are developed based on the SOA and might be considered as complexes of interconnected software tools for working with geospatial data. In the report a complex web mapping system including GIS web client and corresponding OGC services for working with geospatial (NetCDF, PostGIS) dataset archive is presented. There are three basic tiers of the GIS web client in it: 1. Tier of geospatial metadata retrieved from central MySQL repository and represented in JSON format 2. Tier of JavaScript objects implementing methods handling: --- NetCDF metadata --- Task XML object for configuring user calculations, input and output formats --- OGC WMS/WFS cartographical services 3. Graphical user interface (GUI) tier representing JavaScript objects realizing web application business logic Metadata tier consists of a number of JSON objects containing technical information describing geospatial datasets (such as spatio-temporal resolution, meteorological parameters, valid processing methods, etc). The middleware tier of JavaScript objects implementing methods for handling geospatial

  2. SNF5/INI1 Deficiency Redefines Chromatin Remodeling Complex Composition During Tumor Development

    PubMed Central

    Wei, Darmood; Goldfarb, Dennis; Song, Shujie; Cannon, Courtney; Yan, Feng; Sakellariou-Thompson, Donastas; Emanuele, Michael; Major, Michael B.; Weissman, Bernard E.; Kuwahara, Yasumichi

    2014-01-01

    Malignant Rhabdoid Tumors (MRTs), a pediatric cancer that most frequently appears in the kidney and brain, generally lack SNF5 (SMARCB1/INI1), a subunit of the SWI/SNF chromatin-remodeling complex. Recent studies have established that multiple SWI/SNF complexes exist due to the presence or absence of different complex members. Therefore, the effect of SNF5 loss upon SWI/SNF complex formation was investigated in human MRT cells. MRT cells and primary human tumors exhibited reduced levels of many complex proteins. Furthermore, re-expression of SNF5 increased SWI/SNF complex protein levels without concomitant increases in mRNA. Proteomic analysis, using mass spectrometry, of MRT cells before and after SNF5 re-expression indicated the recruitment of different components into the complex along with the expulsion of others. IP-Western blotting confirmed these results and demonstrated similar changes in other MRT cell lines. Finally, reduced expression of SNF5 in normal human fibroblasts led to altered levels of these same complex members. These data establish that SNF5 loss during MRT development alters the repertoire of available SWI/SNF complexes, generally disrupting those associated with cellular differentiation. These findings support a model where SNF5 inactivation blocks the conversion of growth promoting SWI/SNF complexes to differentiation inducing ones. Therefore, restoration of these complexes in tumors cells provides an attractive approach for the treatment of malignant rhabdoid tumors. Implications SNF5 loss dramatically alters SWI/SNF complex composition and prevents formation of complexes required for cellular differentiation. PMID:25009291

  3. The evolving role of Tier2s in ATLAS with the new Computing and Data Distribution model

    NASA Astrophysics Data System (ADS)

    González de la Hoz, S.

    2012-12-01

    Originally the ATLAS Computing and Data Distribution model assumed that the Tier-2s should keep on disk collectively at least one copy of all “active” AOD and DPD datasets. Evolution of ATLAS Computing and Data model requires changes in ATLAS Tier-2s policy for the data replication, dynamic data caching and remote data access. Tier-2 operations take place completely asynchronously with respect to data taking. Tier-2s do simulation and user analysis. Large-scale reprocessing jobs on real data are at first taking place mostly at Tier-1s but will progressively be shared with Tier-2s as well. The availability of disk space at Tier-2s is extremely important in the ATLAS Computing model as it allows more data to be readily accessible for analysis jobs to all users, independently of their geographical location. The Tier-2s disk space has been reserved for real, simulated, calibration and alignment, group, and user data. A buffer disk space is needed for input and output data for simulations jobs. Tier-2s are going to be used more efficiently. In this way Tier-1s and Tier-2s are becoming more equivalent for the network and the hierarchy of Tier-1, 2 is less strict. This paper presents the usage of Tier-2s resources in different Grid activities, caching of data at Tier-2s, and their role in the analysis in the new ATLAS Computing and Data model.

  4. An Analysis of 16-17-Year-Old Students' Understanding of Solution Chemistry Concepts Using a Two-Tier Diagnostic Instrument

    ERIC Educational Resources Information Center

    Adadan, Emine; Savasci, Funda

    2012-01-01

    This study focused on the development of a two-tier multiple-choice diagnostic instrument, which was designed and then progressively modified, and implemented to assess students' understanding of solution chemistry concepts. The results of the study are derived from the responses of 756 Grade 11 students (age 16-17) from 14 different high schools…

  5. Mitochondrial gamma carbonic anhydrases are required for complex I assembly and plant reproductive development.

    PubMed

    Fromm, Steffanie; Braun, Hans-Peter; Peterhansel, Christoph

    2016-07-01

    Complex I of the mitochondrial electron transport chain (mETC) in plants contains an extra domain that is made up from proteins homologous to prokaryotic gamma-carbonic anhydrases (γCA). This domain has been suggested to participate in complex I assembly or to support transport of mitochondrial CO2 to the chloroplast. Here, we generated mutants lacking CA1 and CA2 - two out of three CA proteins in Arabidopsis thaliana. Double mutants were characterized at the developmental and physiological levels. Furthermore, the composition and activity of the mETC were determined, and mutated CA versions were used for complementation assays. Embryo development of double mutants was strongly delayed and seed development stopped before maturation. Mutant plants could only be rescued on sucrose media, showed severe stress symptoms and never produced viable seeds. By contrast, callus cultures were only slightly affected in growth. Complex I was undetectable in the double mutants, but complex II and complex IV were upregulated concomitant with increased oxygen consumption in mitochondrial respiration. Ectopic expression of inactive CA variants was sufficient to complement the mutant phenotype. Data indicate that CA proteins are structurally required for complex I assembly and that reproductive development is dependent on the presence of complex I.

  6. Just healthcare? The moral failure of single-tier basic healthcare.

    PubMed

    Meadowcroft, John

    2015-04-01

    This article sets out the moral failure of single-tier basic healthcare. Single-tier basic healthcare has been advocated on the grounds that the provision of healthcare should be divorced from ability to pay and unequal access to basic healthcare is morally intolerable. However, single-tier basic healthcare encounters a host of catastrophic moral failings. Given the fact of human pluralism it is impossible to objectively define "basic" healthcare. Attempts to provide single-tier healthcare therefore become political processes in which interest groups compete for control of scarce resources with the most privileged possessing an inherent advantage. The focus on outputs in arguments for single-tier provision neglects the question of justice between individuals when some people provide resources for others without reciprocal benefits. The principle that only healthcare that can be provided to everyone should be provided at all leads to a leveling-down problem in which advocates of single-tier provision must prefer a situation where some individuals are made worse-off without any individual being made better-off compared to plausible multi-tier alternatives. Contemporary single-tier systems require the exclusion of noncitizens, meaning that their universalism is a myth. In the light of these pathologies, it is judged that multi-tier healthcare is morally required.

  7. Early responses measured in the brachyuran crab Carcinus maenas exposed to carbamazepine and novobiocin: application of a 2-tier approach.

    PubMed

    Aguirre-Martínez, G V; Del Valls, T A; Martín-Díaz, M L

    2013-11-01

    One of the main consequences of the constant input of pharmaceuticals to the aquatic environment is that biota might develop unknown chronic effects, thus affecting their health even at low concentrations. The aim of this study is to evaluate the health status of Carcinus maenas employing a 2-tier approach, after 28 days of exposure to carbamazepine (CBZ) and novobiocin (NOV) at 0.1, 1, 10 and 50µgL(-1). Lysosomal membrane stability (LMS) is employed in tier 1. In tier 2 was applied a battery of biomarkers of exposure and effect (ethoxyresorufin O-deethylase (EROD), dibenzyl flourescein dealkylase (DBF), glutathione S-transferase (GST), glutathione peroxidase (GPx), lipid peroxidation (LPO) and DNA adducts) measured in gill, hepatopancreas, muscle and gonad tissues. Results show a dose-dependent effect. LMS in crabs exposed to environmental concentrations of pharmaceuticals was significantly lower compared to controls (p<0.05), indicating their stressed status. EROD activity was induced significantly (p<0.05) in all tissues by NOV (10-50µgL(-1)). DBF activity was induced significantly (p<0.05) in gill and hepatopancreas tissues by CBZ (10-50µgL(-1)). GST activity was activated in all tissues of crabs exposed to the highest concentrations tested (p<0.05). All tissues showed induction of GPX activity after exposure to selected drugs (p<0.05). LPO was activated in gill and hepatopancreas tissues by the pharmaceuticals at 50µgL(-1) (p<0.05). Crabs exposed to NOV (50µgL(-1)) presented DNA damage in gill and hepatopancreas tissues (p<0.05). Environmental concentrations of these pharmaceuticals have a measurable effect on the biomarkers studied. The 2-tier approach applied might be a suitable tool for the assessment of sublethal responses in crabs exposed to pharmaceuticals in the marine environment. PMID:23916015

  8. Thermostability of Well-Ordered HIV Spikes Correlates with the Elicitation of Autologous Tier 2 Neutralizing Antibodies

    PubMed Central

    Bale, Shridhar; Kumar, Shailendra; Guenaga, Javier; Wilson, Richard; de Val, Natalia; Arendt, Heather; DeStefano, Joanne; Ward, Andrew B.; Wyatt, Richard T.

    2016-01-01

    In the context of HIV vaccine design and development, HIV-1 spike mimetics displaying a range of stabilities were evaluated to determine whether more stable, well-ordered trimers would more efficiently elicit neutralizing antibodies. To begin, in vitro analysis of trimers derived from the cysteine-stabilized SOSIP platform or the uncleaved, covalently linked NFL platform were evaluated. These native-like trimers, derived from HIV subtypes A, B, and C, displayed a range of thermostabilities, and were “stress-tested” at varying temperatures as a prelude to in vivo immunogenicity. Analysis was performed both in the absence and in the presence of two different adjuvants. Since partial trimer degradation was detected at 37°C before or after formulation with adjuvant, we sought to remedy such an undesirable outcome. Cross-linking (fixing) of the well-ordered trimers with glutaraldehyde increased overall thermostability, maintenance of well-ordered trimer integrity without or with adjuvant, and increased resistance to solid phase-associated trimer unfolding. Immunization of unfixed and fixed well-ordered trimers into animals revealed that the elicited tier 2 autologous neutralizing activity correlated with overall trimer thermostability, or melting temperature (Tm). Glutaraldehyde fixation also led to higher tier 2 autologous neutralization titers. These results link retention of trimer quaternary packing with elicitation of tier 2 autologous neutralizing activity, providing important insights for HIV-1 vaccine design. PMID:27487086

  9. A tiered approach for the human health risk assessment for consumption of vegetables from with cadmium-contaminated land in urban areas

    SciTech Connect

    Swartjes, Frank A. Versluijs, Kees W.; Otte, Piet F.

    2013-10-15

    Consumption of vegetables that are grown in urban areas takes place worldwide. In developing countries, vegetables are traditionally grown in urban areas for cheap food supply. In developing and developed countries, urban gardening is gaining momentum. A problem that arises with urban gardening is the presence of contaminants in soil, which can be taken up by vegetables. In this study, a scientifically-based and practical procedure has been developed for assessing the human health risks from the consumption of vegetables from cadmium-contaminated land. Starting from a contaminated site, the procedure follows a tiered approach which is laid out as follows. In Tier 0, the plausibility of growing vegetables is investigated. In Tier 1 soil concentrations are compared with the human health-based Critical soil concentration. Tier 2 offers the possibility for a detailed site-specific human health risk assessment in which calculated exposure is compared to the toxicological reference dose. In Tier 3, vegetable concentrations are measured and tested following a standardized measurement protocol. To underpin the derivation of the Critical soil concentrations and to develop a tool for site-specific assessment the determination of the representative concentration in vegetables has been evaluated for a range of vegetables. The core of the procedure is based on Freundlich-type plant–soil relations, with the total soil concentration and the soil properties as variables. When a significant plant–soil relation is lacking for a specific vegetable a geometric mean of BioConcentrationFactors (BCF) is used, which is normalized according to soil properties. Subsequently, a ‘conservative’ vegetable-group-consumption-rate-weighted BioConcentrationFactor is calculated as basis for the Critical soil concentration (Tier 1). The tool to perform site-specific human health risk assessment (Tier 2) includes the calculation of a ‘realistic worst case’ site-specific vegetable

  10. Methodological Guidelines for Reducing the Complexity of Data Warehouse Development for Transactional Blood Bank Systems

    PubMed Central

    Takecian, Pedro L.; Oikawa, Marcio K.; Braghetto, Kelly R.; Rocha, Paulo; Lucena, Fred; Kavounis, Katherine; Schlumpf, Karen S.; Acker, Susan; Carneiro-Proietti, Anna B. F.; Sabino, Ester C.; Custer, Brian; Busch, Michael P.; Ferreira, João E.

    2013-01-01

    Over time, data warehouse (DW) systems have become more difficult to develop because of the growing heterogeneity of data sources. Despite advances in research and technology, DW projects are still too slow for pragmatic results to be generated. Here, we address the following question: how can the complexity of DW development for integration of heterogeneous transactional information systems be reduced? To answer this, we proposed methodological guidelines based on cycles of conceptual modeling and data analysis, to drive construction of a modular DW system. These guidelines were applied to the blood donation domain, successfully reducing the complexity of DW development. PMID:23729945

  11. Addressing the Complexity of Writing Development: Toward an Ecological Model of Assessment

    ERIC Educational Resources Information Center

    Wardle, Elizabeth; Roozen, Kevin

    2012-01-01

    This article offers one potential response to Yancey's (1999) call for a fourth wave of writing assessment able to capture writing development in all of its complexity. Based on an ecological perspective of literate development that situates students' growth as writers across multiple engagements with writing, including those outside of school,…

  12. DEVELOPMENT AND CHARACTERIZATION OF NOVEL COMPLEX HYDRIDESSYNTHESIZED VIA MOLTEN STATE PROCESSING

    SciTech Connect

    Zidan, R

    2006-01-09

    This study developed novel hydrides for hydrogen storage through a novel synthesis technique utilizing high hydrogen overpressure at elevated temperatures denoted as Molten State Processing, MSP. The ultimate goal is to produce materials that have high hydrogen capacity, are stable after cycling and possess favorable thermodynamic and kinetic characteristics compatible with onboard hydrogen storage for automotive applications. In order to achieve these goals the MSP Process was developed and used to modify and form new complex hydride compounds with desired characteristics. This synthesis technique holds the potential of fusing different known complex hydrides at elevated temperatures and pressures to form new complexes having different sorption and thermodynamic properties. The new complex hydrides produced by this method were identified through structural determination and thermodynamic characterization in order to achieve a more fundamental understanding of their formation and dissociation mechanisms.

  13. The influence of incompetent lip seal on the growth and development of craniofacial complex.

    PubMed

    Drevensek, Martina; Stefanac-Papić, Jadranka; Farcnik, Franc

    2005-12-01

    Abnormal orofacial functions in the period of growth and development can cause morphological anomalies of the craniofacial complex. The aim of this study was to determine the correlation between open mouth posture and morphology of craniofacial complex. The shape, size and relationships of skeletal parts of craniofacial complex were determined by analysis of lateral cephalograms in the sample of 84 children--45 girls and 39 boys (aged 8.96 +/- 0.66 years). The sample was divided into two groups--lip competence and lip incompetence group. Differences in cephalometric values between observed groups were found. The values of inclination of lower central incisors (angle ILi/NB), interbasal angle (NL/NSL), angle between occlusal and mandibular plane and anterior lower facial height were significantly higher in the group with open mouth posture. It can be concluded that lip incompetence plays an important role in growth and development of craniofacial complex.

  14. Development of Conceptual Benchmark Models to Evaluate Complex Hydrologic Model Calibration in Managed Basins Using Python

    NASA Astrophysics Data System (ADS)

    Hughes, J. D.; White, J.

    2013-12-01

    For many numerical hydrologic models it is a challenge to quantitatively demonstrate that complex models are preferable to simpler models. Typically, a decision is made to develop and calibrate a complex model at the beginning of a study. The value of selecting a complex model over simpler models is commonly inferred from use of a model with fewer simplifications of the governing equations because it can be time consuming to develop another numerical code with data processing and parameter estimation functionality. High-level programming languages like Python can greatly reduce the effort required to develop and calibrate simple models that can be used to quantitatively demonstrate the increased value of a complex model. We have developed and calibrated a spatially-distributed surface-water/groundwater flow model for managed basins in southeast Florida, USA, to (1) evaluate the effect of municipal groundwater pumpage on surface-water/groundwater exchange, (2) investigate how the study area will respond to sea-level rise, and (3) explore combinations of these forcing functions. To demonstrate the increased value of this complex model, we developed a two-parameter conceptual-benchmark-discharge model for each basin in the study area. The conceptual-benchmark-discharge model includes seasonal scaling and lag parameters and is driven by basin rainfall. The conceptual-benchmark-discharge models were developed in the Python programming language and used weekly rainfall data. Calibration was implemented with the Broyden-Fletcher-Goldfarb-Shanno method available in the Scientific Python (SciPy) library. Normalized benchmark efficiencies calculated using output from the complex model and the corresponding conceptual-benchmark-discharge model indicate that the complex model has more explanatory power than the simple model driven only by rainfall.

  15. Condensation heat transfer on two-tier superhydrophobic surfaces

    NASA Astrophysics Data System (ADS)

    Cheng, Jiangtao; Vandadi, Aref; Chen, Chung-Lung

    2012-09-01

    We investigated water vapor condensation on a two-tier superhydrophobic surface in an environmental scanning electron microscope (ESEM) and in a customer-designed vapor chamber. We have observed continuous dropwise condensation (DWC) on the textured surface in ESEM. However, a film layer of condensate was formed on the multiscale texture in the vapor chamber. Due to the filmwise condensation, the condensation heat transfer coefficient of the superhydrophobic surface is lower than that of a flat hydrophobic surface especially under high heat flux situations. Our studies indicate that adaptive and prompt condensate droplet purging is the dominant factor for sustaining long-term DWC.

  16. Dropwise condensation on superhydrophobic surfaces with two-tier roughness

    NASA Astrophysics Data System (ADS)

    Chen, Chuan-Hua; Cai, Qingjun; Tsai, Chialun; Chen, Chung-Lung; Xiong, Guangyong; Yu, Ying; Ren, Zhifeng

    2007-04-01

    Dropwise condensation can enhance heat transfer by an order of magnitude compared to film condensation. Superhydrophobicity appears ideal to promote continued dropwise condensation which requires rapid removal of condensate drops; however, such promotion has not been reported on engineered surfaces. This letter reports continuous dropwise condensation on a superhydrophobic surface with short carbon nanotubes deposited on micromachined posts, a two-tier texture mimicking lotus leaves. On such micro-/nanostructured surfaces, the condensate drops prefer the Cassie state which is thermodynamically more stable than the Wenzel state. With a hexadecanethiol coating, superhydrophobicity is retained during and after condensation and rapid drop removal is enabled.

  17. The Chaoulli Case: a two-tier Magna Carta?

    PubMed

    Marchildon, Gregory P

    2005-01-01

    There has been considerable speculation about the potential impact of the Supreme Court of Canada's judgment in Chaoulli v. Quebec. Even if those who are most friendly--or most hostile--to Canadian medicare are exaggerating the impact of the decision, its impact will be large. While the decision does not strike down any existing single-payer medicare system in any province, including Quebec's single-payer system, it is certainly capable of becoming the Magna Carta for two-tier medicare through future judicial interpretation and extension. In any event, it has already become the battering ram of choice for medicare's most tenacious opponents.

  18. Developing mononuclear copper-active-oxygen complexes relevant to reactive intermediates of biological oxidation reactions.

    PubMed

    Itoh, Shinobu

    2015-07-21

    Active-oxygen species generated on a copper complex play vital roles in several biological and chemical oxidation reactions. Recent attention has been focused on the reactive intermediates generated at the mononuclear copper active sites of copper monooxygenases such as dopamine β-monooxygenase (DβM), tyramine β-monooxygenase (TβM), peptidylglycine-α-hydroxylating monooxygenase (PHM), and polysaccharide monooxygenases (PMO). In a simple model system, reaction of O2 and a reduced copper(I) complex affords a mononuclear copper(II)-superoxide complex or a copper(III)-peroxide complex, and subsequent H(•) or e(-)/H(+) transfer, which gives a copper(II)-hydroperoxide complex. A more reactive species such as a copper(II)-oxyl radical type species could be generated via O-O bond cleavage of the peroxide complex. However, little had been explored about the chemical properties and reactivity of the mononuclear copper-active-oxygen complexes due to the lack of appropriate model compounds. Thus, a great deal of effort has recently been made to develop efficient ligands that can stabilize such reactive active-oxygen complexes in synthetic modeling studies. In this Account, I describe our recent achievements of the development of a mononuclear copper(II)-(end-on)superoxide complex using a simple tridentate ligand consisting of an eight-membered cyclic diamine with a pyridylethyl donor group. The superoxide complex exhibits a similar structure (four-coordinate tetrahedral geometry) and reactivity (aliphatic hydroxylation) to those of a proposed reactive intermediate of copper monooxygenases. Systematic studies based on the crystal structures of copper(I) and copper(II) complexes of the related tridentate supporting ligands have indicated that the rigid eight-membered cyclic diamine framework is crucial for controlling the geometry and the redox potential, which are prerequisites for the generation of such a unique mononuclear copper(II)-(end-on)superoxide complex

  19. Application of a tiered approach to the validation of accelerator MS assays.

    PubMed

    Higton, David; Seymour, Mark

    2014-03-01

    Since its introduction into the drug-development arena, accelerator mass spectrometry (coupled with liquid chromatography fractionation) has been used to support a variety of study types. The uses to which the technique has been put include parent and/or metabolite quantification in pharmacokinetic studies, total radioactivity measurement in adsorption, metabolism and excretion studies, and quantitative metabolite profiling. A tiered approach has been applied to the verification of accelerator mass spectrometry assays, dependant on in which type of study and at what stage of drug development they are used. As accelerator mass spectrometry is an absolute detector that can quantify without the use of analyte-related standards, the specific assay verification requirements differ from those for LC-MS/MS assays. This article describes when screening, qualified and validated assay verification procedures should be applied, and suggests what parameters should be assessed in each case.

  20. General and craniofacial development are complex adaptive processes influenced by diversity.

    PubMed

    Brook, A H; O'Donnell, M Brook; Hone, A; Hart, E; Hughes, T E; Smith, R N; Townsend, G C

    2014-06-01

    Complex systems are present in such diverse areas as social systems, economies, ecosystems and biology and, therefore, are highly relevant to dental research, education and practice. A Complex Adaptive System in biological development is a dynamic process in which, from interacting components at a lower level, higher level phenomena and structures emerge. Diversity makes substantial contributions to the performance of complex adaptive systems. It enhances the robustness of the process, allowing multiple responses to external stimuli as well as internal changes. From diversity comes variation in outcome and the possibility of major change; outliers in the distribution enhance the tipping points. The development of the dentition is a valuable, accessible model with extensive and reliable databases for investigating the role of complex adaptive systems in craniofacial and general development. The general characteristics of such systems are seen during tooth development: self-organization; bottom-up emergence; multitasking; self-adaptation; variation; tipping points; critical phases; and robustness. Dental findings are compatible with the Random Network Model, the Threshold Model and also with the Scale Free Network Model which has a Power Law distribution. In addition, dental development shows the characteristics of Modularity and Clustering to form Hierarchical Networks. The interactions between the genes (nodes) demonstrate Small World phenomena, Subgraph Motifs and Gene Regulatory Networks. Genetic mechanisms are involved in the creation and evolution of variation during development. The genetic factors interact with epigenetic and environmental factors at the molecular level and form complex networks within the cells. From these interactions emerge the higher level tissues, tooth germs and mineralized teeth. Approaching development in this way allows investigation of why there can be variations in phenotypes from identical genotypes; the phenotype is the outcome

  1. General and craniofacial development are complex adaptive processes influenced by diversity.

    PubMed

    Brook, A H; O'Donnell, M Brook; Hone, A; Hart, E; Hughes, T E; Smith, R N; Townsend, G C

    2014-06-01

    Complex systems are present in such diverse areas as social systems, economies, ecosystems and biology and, therefore, are highly relevant to dental research, education and practice. A Complex Adaptive System in biological development is a dynamic process in which, from interacting components at a lower level, higher level phenomena and structures emerge. Diversity makes substantial contributions to the performance of complex adaptive systems. It enhances the robustness of the process, allowing multiple responses to external stimuli as well as internal changes. From diversity comes variation in outcome and the possibility of major change; outliers in the distribution enhance the tipping points. The development of the dentition is a valuable, accessible model with extensive and reliable databases for investigating the role of complex adaptive systems in craniofacial and general development. The general characteristics of such systems are seen during tooth development: self-organization; bottom-up emergence; multitasking; self-adaptation; variation; tipping points; critical phases; and robustness. Dental findings are compatible with the Random Network Model, the Threshold Model and also with the Scale Free Network Model which has a Power Law distribution. In addition, dental development shows the characteristics of Modularity and Clustering to form Hierarchical Networks. The interactions between the genes (nodes) demonstrate Small World phenomena, Subgraph Motifs and Gene Regulatory Networks. Genetic mechanisms are involved in the creation and evolution of variation during development. The genetic factors interact with epigenetic and environmental factors at the molecular level and form complex networks within the cells. From these interactions emerge the higher level tissues, tooth germs and mineralized teeth. Approaching development in this way allows investigation of why there can be variations in phenotypes from identical genotypes; the phenotype is the outcome

  2. Permitted Complexity in Phonological Development: One Child's Acquisition of Spanish Consonants. Papers and Reports on Child Language Development, No. 11.

    ERIC Educational Resources Information Center

    Macken, Marlys A.

    Data are presented from one subject (J) that show a gradual development of the complexity of words in terms of syllable structure and degree of phonetic similarity of co-occurring consonants. During the age range of 1;9 to 2;6, J's data show a highly systematic progression of stages, each characterized by fewer restrictions on the number, order,…

  3. Tier 3 batch system data locality via managed caches

    NASA Astrophysics Data System (ADS)

    Fischer, Max; Giffels, Manuel; Jung, Christopher; Kühn, Eileen; Quast, Günter

    2015-05-01

    Modern data processing increasingly relies on data locality for performance and scalability, whereas the common HEP approaches aim for uniform resource pools with minimal locality, recently even across site boundaries. To combine advantages of both, the High- Performance Data Analysis (HPDA) Tier 3 concept opportunistically establishes data locality via coordinated caches. In accordance with HEP Tier 3 activities, the design incorporates two major assumptions: First, only a fraction of data is accessed regularly and thus the deciding factor for overall throughput. Second, data access may fallback to non-local, making permanent local data availability an inefficient resource usage strategy. Based on this, the HPDA design generically extends available storage hierarchies into the batch system. Using the batch system itself for scheduling file locality, an array of independent caches on the worker nodes is dynamically populated with high-profile data. Cache state information is exposed to the batch system both for managing caches and scheduling jobs. As a result, users directly work with a regular, adequately sized storage system. However, their automated batch processes are presented with local replications of data whenever possible.

  4. 20 CFR 209.14 - Report of separation allowances subject to tier II taxation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Report of separation allowances subject to tier II taxation. 209.14 Section 209.14 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER... separation allowances subject to tier II taxation. For any employee who is paid a separation payment,...

  5. 26 CFR 53.4961-2 - Court proceedings to determine liability for second tier tax.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... or collection of first or second tier tax may be prohibited during the pendency of administrative and... Court, the provisions of the second and third sentences of section 6213(a) and the first and third... second tier tax. 53.4961-2 Section 53.4961-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF...

  6. 26 CFR 53.4961-2 - Court proceedings to determine liability for second tier tax.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... or collection of first or second tier tax may be prohibited during the pendency of administrative and... Court, the provisions of the second and third sentences of section 6213(a) and the first and third... second tier tax. 53.4961-2 Section 53.4961-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF...

  7. 26 CFR 53.4961-2 - Court proceedings to determine liability for second tier tax.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... or collection of first or second tier tax may be prohibited during the pendency of administrative and... Court, the provisions of the second and third sentences of section 6213(a) and the first and third... second tier tax. 53.4961-2 Section 53.4961-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF...

  8. 26 CFR 53.4961-2 - Court proceedings to determine liability for second tier tax.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... or collection of first or second tier tax may be prohibited during the pendency of administrative and... Court, the provisions of the second and third sentences of section 6213(a) and the first and third... second tier tax. 53.4961-2 Section 53.4961-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF...

  9. 26 CFR 53.4961-2 - Court proceedings to determine liability for second tier tax.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... or collection of first or second tier tax may be prohibited during the pendency of administrative and... Court, the provisions of the second and third sentences of section 6213(a) and the first and third... second tier tax. 53.4961-2 Section 53.4961-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF...

  10. Integrating Multi-Tiered Measurement Outcomes for Special Education Eligibility with Sequential Decision-Making Methodology

    ERIC Educational Resources Information Center

    Decker, Scott L.; Englund, Julia; Albritton, Kizzy

    2012-01-01

    Changes to federal guidelines for the identification of children with disabilities have supported the use of multi-tiered models of service delivery. This study investigated the impact of measurement methodology as used across numerous tiers in determining special education eligibility. Four studies were completed using a sample of inner-city…

  11. 29 CFR 1918.83 - Stowed cargo; tiering and breaking down.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 7 2013-07-01 2013-07-01 false Stowed cargo; tiering and breaking down. 1918.83 Section... cargo; tiering and breaking down. (a) When necessary to protect personnel working in a hold, the employer shall secure or block stowed cargo that is likely to shift or roll. (b) In breaking down...

  12. 29 CFR 1918.83 - Stowed cargo; tiering and breaking down.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 7 2011-07-01 2011-07-01 false Stowed cargo; tiering and breaking down. 1918.83 Section... cargo; tiering and breaking down. (a) When necessary to protect personnel working in a hold, the employer shall secure or block stowed cargo that is likely to shift or roll. (b) In breaking down...

  13. 29 CFR 1918.83 - Stowed cargo; tiering and breaking down.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 7 2012-07-01 2012-07-01 false Stowed cargo; tiering and breaking down. 1918.83 Section... cargo; tiering and breaking down. (a) When necessary to protect personnel working in a hold, the employer shall secure or block stowed cargo that is likely to shift or roll. (b) In breaking down...

  14. 29 CFR 1918.83 - Stowed cargo; tiering and breaking down.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Stowed cargo; tiering and breaking down. 1918.83 Section... cargo; tiering and breaking down. (a) When necessary to protect personnel working in a hold, the employer shall secure or block stowed cargo that is likely to shift or roll. (b) In breaking down...

  15. 29 CFR 1918.83 - Stowed cargo; tiering and breaking down.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 7 2014-07-01 2014-07-01 false Stowed cargo; tiering and breaking down. 1918.83 Section... cargo; tiering and breaking down. (a) When necessary to protect personnel working in a hold, the employer shall secure or block stowed cargo that is likely to shift or roll. (b) In breaking down...

  16. Differentiating by Readiness: Strategies and Lesson Plans for Tiered Instruction, Grades K-8

    ERIC Educational Resources Information Center

    Turville, Joni; Allen, Linda; Nickelsen, LeAnn

    2010-01-01

    This book provides a comprehensive introduction to tiering plus step-by-step instructions for using it in your classroom. Also included are 23 ready-to-apply blackline masters, which provide helpful ideas for activities and classroom management. Contents include: (1) Building the foundation: What is tiering in differentiated instruction?; (2) The…

  17. 75 FR 77869 - Endocrine Disruptor Screening Program; Second List of Chemicals for Tier 1 Screening; Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-14

    ... (75 FR 70248) (FRL-8848-7). In that notice, EPA announced the second list of chemicals and substances... AGENCY Endocrine Disruptor Screening Program; Second List of Chemicals for Tier 1 Screening; Extension of... Endocrine Disruptor Screening Program's (EDSP) second list of chemicals for Tier 1 screening. This...

  18. Transporting Motivational Interviewing to School Settings to Improve the Engagement and Fidelity of Tier 2 Interventions

    ERIC Educational Resources Information Center

    Frey, Andy J.; Lee, Jon; Small, Jason W.; Seeley, John R.; Walker, Hill M.; Feil, Edward G.

    2013-01-01

    The majority of Tier 2 interventions are facilitated by specialized instructional support personnel, such as a school psychologists, school social workers, school counselors, or behavior consultants. Many professionals struggle to involve parents and teachers in Tier 2 behavior interventions. However, attention to the motivational issues for…

  19. Tiering and Scaffolding: Two Strategies for Providing Access to Important Mathematics

    ERIC Educational Resources Information Center

    Williams, Lori

    2008-01-01

    Tiering and scaffolding are two differentiation strategies that teachers use to support access to a high-quality mathematics curriculum for all students. This article provides examples demonstrating a thinking process for planning tiered activities that focus on important mathematical understandings. Also described are possible scaffolds that can…

  20. Fundamentalists, Priests, Martyrs and Converts: A Typology of First Tier Management in Further Education

    ERIC Educational Resources Information Center

    Page, Damien

    2011-01-01

    This article presents findings from a study of first tier managers in English Further Education colleges, a role critically neglected within the literature, despite its centrality to organisational effectiveness and learner success. The role was found to be diverse, contested and elastic and while first tier managers were found to be highly…

  1. 49 CFR Appendix D to Part 238 - Requirements for External Fuel Tanks on Tier I Locomotives

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... properties of the locomotive fuel tank to reduce the risk of fuel spillage to acceptable levels under... 49 Transportation 4 2010-10-01 2010-10-01 false Requirements for External Fuel Tanks on Tier I..., App. D Appendix D to Part 238—Requirements for External Fuel Tanks on Tier I Locomotives...

  2. 49 CFR Appendix D to Part 238 - Requirements for External Fuel Tanks on Tier I Locomotives

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... properties of the locomotive fuel tank to reduce the risk of fuel spillage to acceptable levels under... 49 Transportation 4 2011-10-01 2011-10-01 false Requirements for External Fuel Tanks on Tier I..., App. D Appendix D to Part 238—Requirements for External Fuel Tanks on Tier I Locomotives...

  3. 40 CFR 158.510 - Tiered testing options for nonfood pesticides.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Tiered testing options for nonfood...) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Toxicology § 158.510 Tiered testing options for nonfood... toxicology data. The requirement for additional second and third level toxicology testing will be...

  4. 40 CFR 158.510 - Tiered testing options for nonfood pesticides.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Tiered testing options for nonfood...) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Toxicology § 158.510 Tiered testing options for nonfood... toxicology data. The requirement for additional second and third level toxicology testing will be...

  5. 40 CFR 158.510 - Tiered testing options for nonfood pesticides.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Tiered testing options for nonfood...) PESTICIDE PROGRAMS DATA REQUIREMENTS FOR PESTICIDES Toxicology § 158.510 Tiered testing options for nonfood... toxicology data. The requirement for additional second and third level toxicology testing will be...

  6. 40 CFR 87.21 - Exhaust emission standards for Tier 4 and earlier engines.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...: Hydrocarbons: 19.6 grams/kilonewton rO. (ii) Engines manufactured on or after July 7, 1997. Carbon Monoxide: 118 grams/kilonewton rO. (iii) The following Tier 0 emission standard applies for engines of a type or... 31, 1999. Oxides of Nitrogen: (40 + 2(rPR)) grams/kilonewton rO. (iv) The following Tier 2...

  7. 75 FR 33389 - TierOne Bank Lincoln, Nebraska; Notice of Appointment of Receiver

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Office of Thrift Supervision TierOne Bank Lincoln, Nebraska; Notice of Appointment of Receiver Notice is... Receiver for TierOne Bank, Lincoln, Nebraska, (OTS No. 03309), on June 4, 2010. Dated: June 7, 2010. By...

  8. Two-Tier Compensation Structures. Their Impact on Unions, Employers, and Employees.

    ERIC Educational Resources Information Center

    Martin, James E.; Heetderks, Thomas D.

    This book examines in detail the impact of tiered compensation structures on unions, employers, and employees. (Tiered compensation structures are defined as pay systems in which employees who start working or change jobs in a company after a certain date receive a lower rate of pay than employees who were doing the same or similar jobs before…

  9. 40 CFR Appendix G to Part 112 - Tier I Qualified Facility SPCC Plan

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Tier I Qualified Facility SPCC Plan G Appendix G to Part 112 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION Pt. 112, App. G Appendix G to Part 112—Tier I Qualified Facility SPCC...

  10. 40 CFR 725.426 - Applicability of the Tier I exemption.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS General Exemptions for New Microorganisms § 725.426 Applicability of the Tier I exemption. The Tier I exemption under § 725.424 applies only to a manufacturer or importer of a new microorganism that certifies that...

  11. 40 CFR 725.428 - Requirements for the Tier II exemption.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS General Exemptions for New Microorganisms § 725.428 Requirements for the Tier II exemption. The manufacturer or importer of a new microorganism for commercial purposes may submit to EPA a Tier II exemption request in lieu of...

  12. 40 CFR 725.426 - Applicability of the Tier I exemption.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS General Exemptions for New Microorganisms § 725.426 Applicability of the Tier I exemption. The Tier I exemption under § 725.424 applies only to a manufacturer or importer of a new microorganism that certifies that...

  13. 40 CFR 725.426 - Applicability of the Tier I exemption.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS General Exemptions for New Microorganisms § 725.426 Applicability of the Tier I exemption. The Tier I exemption under § 725.424 applies only to a manufacturer or importer of a new microorganism that certifies that...

  14. 40 CFR 725.428 - Requirements for the Tier II exemption.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS General Exemptions for New Microorganisms § 725.428 Requirements for the Tier II exemption. The manufacturer or importer of a new microorganism for commercial purposes may submit to EPA a Tier II exemption request in lieu of...

  15. A Review of Tier 2 Interventions Conducted within Multitiered Models of Behavioral Prevention

    ERIC Educational Resources Information Center

    Bruhn, Allison Leigh; Lane, Kathleen Lynne; Hirsch, Shanna Eisner

    2014-01-01

    To support students' academic, behavioral, and social needs, many schools have adopted multitiered models of prevention. Because Tier 3 interventions are costly in terms of time and resources, schools must find efficient and effective Tier 2 interventions prior to providing such intense supports. In this article, we review the literature base…

  16. 48 CFR 213.106-1-70 - Soliciting competition-tiered evaluation of offers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Soliciting competition-tiered evaluation of offers. 213.106-1-70 Section 213.106-1-70 Federal Acquisition Regulations System... SIMPLIFIED ACQUISITION PROCEDURES Procedures 213.106-1-70 Soliciting competition—tiered evaluation of...

  17. 48 CFR 213.106-1-70 - Soliciting competition-tiered evaluation of offers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Soliciting competition-tiered evaluation of offers. 213.106-1-70 Section 213.106-1-70 Federal Acquisition Regulations System... SIMPLIFIED ACQUISITION PROCEDURES Procedures 213.106-1-70 Soliciting competition—tiered evaluation of...

  18. 48 CFR 213.106-1-70 - Soliciting competition-tiered evaluation of offers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Soliciting competition-tiered evaluation of offers. 213.106-1-70 Section 213.106-1-70 Federal Acquisition Regulations System... SIMPLIFIED ACQUISITION PROCEDURES Procedures 213.106-1-70 Soliciting competition—tiered evaluation of...

  19. 48 CFR 213.106-1-70 - Soliciting competition-tiered evaluation of offers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Soliciting competition-tiered evaluation of offers. 213.106-1-70 Section 213.106-1-70 Federal Acquisition Regulations System... SIMPLIFIED ACQUISITION PROCEDURES Procedures 213.106-1-70 Soliciting competition—tiered evaluation of...

  20. 48 CFR 213.106-1-70 - Soliciting competition-tiered evaluation of offers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Soliciting competition-tiered evaluation of offers. 213.106-1-70 Section 213.106-1-70 Federal Acquisition Regulations System... SIMPLIFIED ACQUISITION PROCEDURES Procedures 213.106-1-70 Soliciting competition—tiered evaluation of...

  1. Using Regression Discontinuity to Test the Impact of a Tier 2 Reading Intervention in First Grade

    ERIC Educational Resources Information Center

    Baker, Scott K.; Smolkowski, Keith; Chaparro, Erin A.; Smith, Jean L. M.; Fien, Hank

    2015-01-01

    Multitiered systems of reading instruction and intervention, including response to intervention, are widely used in early reading by schools to provide more intense services to students who need them. Research using randomized controlled trials has compared innovative Tier 2 interventions to business-as-usual Tier 2 approaches and established a…

  2. The Impact of Tier 2 Mathematics Instruction on Second Graders with Mathematics Difficulties

    ERIC Educational Resources Information Center

    Dennis, Minyi Shih; Bryant, Brian R.; Drogan, Robin

    2015-01-01

    Although research on Tier 2 interventions for early mathematics is accumulating, such efforts remain far behind those for reading, especially regarding specific features such as the ideal time to begin an intervention. The present study investigated the effectiveness of a Tier 2 intervention using a single subject multiple baseline, across-groups…

  3. Tiered Intervention: History and Trends in Finland and the United States

    ERIC Educational Resources Information Center

    Jahnukainen, Markku; Itkonen, Tiina

    2016-01-01

    This study explores the similarities and differences of relatively newly established tiered intervention models for the support of students with special needs in the United States (response to intervention) and in Finland (learning and schooling support). The current models in both countries consist of several tiers with fairly similar…

  4. The Top 10 Things to Consider when Implementing Secondary-Tier PBIS Interventions

    ERIC Educational Resources Information Center

    Ennis, Robin Parks; Swoszowski, Nicole Cain

    2011-01-01

    Schools across the country have seen the benefits of implementing three-tiered models of positive behavioral interventions and supports (PBIS). Within that model, secondary-tier (ST) interventions are an essential component because they (a) require relatively little implementation time compared with more intensive interventions, (b) address the…

  5. 40 CFR Appendix G to Part 112 - Tier I Qualified Facility SPCC Plan

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Tier I Qualified Facility SPCC Plan G Appendix G to Part 112 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL POLLUTION PREVENTION Pt. 112, App. G Appendix G to Part 112—Tier I Qualified Facility SPCC...

  6. 40 CFR 141.204 - Tier 3 Public Notice-Form, manner, and frequency of notice.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Other Situations Requiring a Tier 3 Public Notice (1) Monitoring violations under 40 CFR part 141... Tier 2 notice is required; (2) Failure to comply with a testing procedure established in 40 CFR part... contaminant monitoring results, as required under § 141.207; and (5) Exceedance of the fluoride...

  7. Effects of a Response-Based, Tiered Framework for Intervening with Struggling Readers in Middle School

    ERIC Educational Resources Information Center

    Roberts, Greg; Vaughn, Sharon; Fletcher, Jack; Stuebing, Karla; Barth, Amy

    2013-01-01

    This study addressed the effects of multiyear, response-based, tiered intervention for struggling readers in grades 6-8. A sample of 768 sixth-grade students with reading difficulties was randomized to a response-based, tiered-intervention condition or "business as usual," and initial treatment status was maintained over the three-year…

  8. 7 CFR 1710.114 - TIER, DSC, OTIER and ODSC requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... substantially in their entirety are in 7 CFR 1717.155. (4) If a distribution borrower has in service or under... 7 Agriculture 11 2010-01-01 2010-01-01 false TIER, DSC, OTIER and ODSC requirements. 1710.114... AND GUARANTEES Loan Purposes and Basic Policies § 1710.114 TIER, DSC, OTIER and ODSC requirements....

  9. Effects of Multi-Tier Academic and Behavior Instruction on Difficult-to-Teach Students

    ERIC Educational Resources Information Center

    Algozzine, Bob; Wang, Chuang; White, Richard; Cooke, Nancy; Marr, Mary Beth; Algozzine, Kate; Helf, Shawnna S.; Duran, Grace Zamora

    2012-01-01

    This article addresses the effects of 3-tiered comprehensive reading and behavior interventions on K-3 student outcomes in 7 urban elementary schools with a high prevalence of students considered difficult to teach. Specific features of each level of the implementation are described including screening and tier placement procedures, scheduling and…

  10. 40 CFR 725.428 - Requirements for the Tier II exemption.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS General Exemptions for New Microorganisms § 725.428 Requirements for the Tier II exemption. The manufacturer or importer of a new microorganism for commercial purposes may submit to EPA a Tier II exemption request in lieu of...

  11. 40 CFR 725.428 - Requirements for the Tier II exemption.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS General Exemptions for New Microorganisms § 725.428 Requirements for the Tier II exemption. The manufacturer or importer of a new microorganism for commercial purposes may submit to EPA a Tier II exemption request in lieu of...

  12. 40 CFR 725.426 - Applicability of the Tier I exemption.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS General Exemptions for New Microorganisms § 725.426 Applicability of the Tier I exemption. The Tier I exemption under § 725.424 applies only to a manufacturer or importer of a new microorganism that certifies that...

  13. 40 CFR 725.426 - Applicability of the Tier I exemption.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SUBSTANCES CONTROL ACT REPORTING REQUIREMENTS AND REVIEW PROCESSES FOR MICROORGANISMS General Exemptions for New Microorganisms § 725.426 Applicability of the Tier I exemption. The Tier I exemption under § 725.424 applies only to a manufacturer or importer of a new microorganism that certifies that...

  14. Three-Tier Models of Reading and Behavior: A Research Review

    ERIC Educational Resources Information Center

    Stewart, Rachel M.; Benner, Gregory J.; Martella, Ronald C.; Marchand-Martella, Nancy E.

    2007-01-01

    The purpose of this study was to analyze the research literature on three-tier models of reading and behavior and to provide a descriptive analysis and meta-analytic review of these models. An in-depth review of 17 articles was conducted on the similarities and differences between and among three-tier models of reading (n = 5), models of behavior…

  15. Differentiating Tier 2 Social Behavioral Interventions According to Function of Behavior

    ERIC Educational Resources Information Center

    Reinke, Wendy M.; Stormont, Melissa; Clare, Ann; Latimore, Tracey; Herman, Keith C.

    2013-01-01

    Schools implementing tiered supports for social behavior need to be systematic and thoughtful about moving to the next tier. However, schools often apply resources they have in a blanket fashion for children who demonstrate behavior problems. This practice is problematic, and there is a need for increased efforts to plan and be more careful about…

  16. Data-Driven Delivery of Implementation Supports in a Multi-Tiered Framework: A Pilot Study

    ERIC Educational Resources Information Center

    Sanetti, Lisa M. Hagermoser; Collier-Meek, Melissa A.

    2015-01-01

    For multi-tiered systems of support, such as Response-to-Intervention and Positive Behavior Interventions and Supports, to effectively impact student outcomes, interventions delivered across the tiers must be implemented as planned (i.e., with adequate treatment integrity). However, research suggests that most school personnel struggle to deliver…

  17. Knowledge Management Systems and Open Innovation in Second Tier UK Universities

    ERIC Educational Resources Information Center

    Chaston, Ian

    2012-01-01

    The purpose of this paper is to examine the performance of second tier UK universities in relation to the effectiveness of their knowledge management systems and involvement in open innovation. Data were acquired using a mail survey of academic staff in social science and business faculties in second tier institutions. The results indicate that…

  18. The Application of a Three-Tier Model of Intervention to Parent Training

    ERIC Educational Resources Information Center

    Phaneuf, Leah; McIntyre, Laura Lee

    2011-01-01

    A three-tier intervention system was designed for use with parents with preschool children with developmental disabilities to modify parent-child interactions. A single-subject changing-conditions design was used to examine the utility of a three-tier intervention system in reducing negative parenting strategies, increasing positive parenting…

  19. If you have tiers to shed, shed them for the patient.

    PubMed

    Pealing, J

    1980-02-22

    If the NHS has one tier too many, perhaps this is true also of the nursing management structure inherited from Salmon. John Pealing, district nursing officer, SE Staffs, and based at Burton-on-Trent, describes a structure in which nursing officers are accountable to the divisional nursing officer, without an intervening tier of SNOs.

  20. Complexity and clinical governance: using the insights to develop the strategy.

    PubMed Central

    Sweeney, Kieran G; Mannion, Russell

    2002-01-01

    There is increasing interest in complexity as an explanatory model to help understand how health care organisations operate and change. In this article, we present a brief introduction to some of the basic ideas in complexity and illustrate how these might be relevant to the process of implementing clinical governance. The implementation of clinical governance can be seen as a complex adaptive system: as such, we must accept that uncertainty and unpredictability are inescapable. This makes life uncomfortable for managers, but an understanding of how complex adaptive systems work helps us explore a range or management styles and practices, depending on how the 'system'--in this case the implementation of clinical govenance--is developing. PMID:12389762

  1. The Complexity Signature: Developing a Tool to Communicate Biopsychosocial Severity of Disease for Children with Chronic Neurological Complexity.

    PubMed

    Krieg, Sandro M; Sonanini, Sebastian; Sollmann, Nico; Focke, Axel; Gerstl, Lucia; Heinen, Florian

    2016-08-01

    Aim For children with medical complexity, interdisciplinary treatment approaches are required to address the various aspects defined within the biopsychosocial model. Methods The present study identifies dimensions of the biopsychosocial model to generate a standardized visualized severity score for chronic neurological diseases in children. We demonstrate the score's applicability and usefulness in clinical practice among clinicians with and without pediatric board certification with the aid of illustrative patient cases. The results are compared by Spearman correlation coefficient. Results Nine dimensions were identified as the basis for the development of the score, which consists of five grades of severity for each of the selected neuropediatric subsections. All board-certified pediatricians would recommend the application of the severity score in clinical routine. Furthermore, a good correlation was revealed between direct and indirect (severity score) assessment. Interpretation The severity score developed in this study takes into account biopsychosocial aspects of chronic diseases while being comprehensible and easily applicable in clinical routine-a biopsychosocial signature serving as an excellent, striking communication basis within the interdisciplinary team. However, upcoming studies including more patient cases are needed for further refinement. PMID:27228000

  2. Limiting solidarity in the Netherlands: a two-tier system on the way.

    PubMed

    Ter Meulen, R H

    1995-12-01

    Health care policy in the Netherlands has long been guided by the values of solidarity and equality. As a result of several forces, particularly the scarcity of resources, the retreat of the Welfare State and the introduction of market forces in health care, both values are increasingly under strain. Next to solidarity and equality, freedom of choice and financial responsibility are playing an important role in Dutch health care. Consequently, there is a growing division in Dutch health care between two tiers, one basic tier giving access to a basic package of services and a luxury tier giving access to a higher quality of care and to services not included in the basic package. The main thesis of the article is that a two-tier system is morally justified on the condition that the basic tier is universally accessible and is based on the value of humanitarian solidarity. PMID:11608826

  3. Menaquinone and Iron Are Essential for Complex Colony Development in Bacillus subtilis

    PubMed Central

    Pelchovich, Gidi; Omer-Bendori, Shira; Gophna, Uri

    2013-01-01

    Cells of undomesticated species of Bacillus subtilis frequently form complex colonies during spreading on agar surfaces. Given that menaquinone is involved in another form of coordinated behavior, namely, sporulation, we looked for a possible role for menaquinone in complex colony development (CCD) in the B. subtilis strain NCIB 3610. Here we show that inhibition of menaquinone biosynthesis in B. subtilis indeed abolished its ability to develop complex colonies. Additionally some mutations of B. subtilis which confer defective CCD could be suppressed by menaquinone derivatives. Several such mutants mapped to the dhb operon encoding the genes responsible for the biosynthesis of the iron siderophore, bacillibactin. Our results demonstrate that both menaquinone and iron are essential for CCD in B. subtilis. PMID:24223955

  4. Development and characterization of nanoparticulate formulation of a water soluble prodrug of dexamethasone by HIP complexation

    PubMed Central

    Gaudana, Ripal; Parenky, Ashwin; Vaishya, Ravi; Samanta, Swapan K.; Mitra, Ashim K.

    2015-01-01

    The objective of this study was to develop and characterize a nanoparticulate-based sustained release formulation of a water soluble dipeptide prodrug of dexamethasone, valine–valine-dexamethasone (VVD). Being hydrophilic in nature, it readily leaches out in the external aqueous medium and hence partitions poorly into the polymeric matrix resulting in minimal entrapment in nanoparticles. Hence, hydrophobic ion pairing (HIP) complexation of the prodrug was employed with dextran sulphate as a complexing polymer. A novel, solid in oil in water emulsion method was employed to encapsulate the prodrug in HIP complex form in poly(lactic-co-glycolic acid) matrix. Nanoparticles were characterized with respect to size, zeta potential, crystallinity of entrapped drug and surface morphology. A significant enhancement in the entrapment of the prodrug in nanoparticles was achieved. Finally, a simple yet novel method was developed which can also be applicable to encapsulate other charged hydrophilic molecules, such as peptides and proteins. PMID:20939702

  5. Neuropsychological Outcomes in Extremely Preterm Preschoolers Exposed to Tiered Low Oxygen Targets: An Observational Study.

    PubMed

    Baron, Ida Sue; Weiss, Brandi A; Baker, Robin; Ahronovich, Margot D; Litman, Fern R; Baveja, Rajiv

    2016-03-01

    An observational study of neuropsychological outcomes at preschool age of tiered lowered oxygen (O2) saturation targets in extremely preterm neonates. We studied 111 three-year-olds born <28 weeks' gestational age. Fifty-nine participants born in 2009-2010 during a time-limited quality improvement initiative each received three-tiered stratification of oxygen rates (83-93% until age 32 weeks, 85-95% until age 35 weeks, and 95% after age 35 weeks), the TieredO2 group. Comparisons were made with 52 participants born in 2007-2008 when pre-initiative saturation targets were non-tiered at 89-100%, the Non-tieredO2 group. Neuropsychological domains included general intellectual, executive, attention, language, visuoperceptual, visual-motor, and fine and gross motor functioning. Descriptive and inferential analyses were conducted. Group comparisons were not statistically significant. Descriptively, the TieredO2 group had better general intellectual, executive function, visual-motor, and motor performance and the Non-tieredO2 group had better language performance. Cohen's d and confidence intervals around d were in similar direction and magnitude across measures. A large effect size was found for recall of digits-forward in participants born at 23 and 24 weeks' gestation, d=0.99 and 1.46, respectively. Better TieredO2 outcomes in all domains except language suggests that the tiered oxygen saturation target method is not harmful and merits further investigation through further studies. Benefit in auditory attention appeared greatest in those born at 23 and 24 weeks. Participants in the tiered oxygen saturation group also had fewer ventilation days and a lower incidence of bronchopulmonary dysplasia, perhaps explanatory for these neuropsychological outcomes at age 3. PMID:26646724

  6. Development of a method for determining the relative manufacturing complexity of advanced engineering materials

    NASA Astrophysics Data System (ADS)

    Pandya, Shardul Yogendra

    The immediate adaptation of newly developed materials--with unique and highly desirable properties--is hampered by several factors, including: (1) high material cost and limited availability, (2) lack of information on them, including prior experience in their design and manufacture, immature manufacturing processes and general uncertainty in their behavior patterns, (3) unique handling issues, such as excessive manual labor, high process temperatures, toxicity, disposal problems, limited working lives, and low damage tolerance Therefore, in spite of their significant benefits, potential users tend to shy away from the widespread use of new materials, instead preferring conventional and tested materials forms. This dissertation is on a methodology developed to compare manufacturing complexity of new materials with that of conventional ones. It entails development of a 5 level multi-attribute hierarchy of 18 factors and several processes that influence the manufacturing risk of new materials. A Manufacturing Complexity Factor (MCF) and a Delta Complexity Factor (DCF) are developed to compare new materials with older, traditional ones. The Analytic Hierarchy Process is used to judiciously assign weights to all factors and sub-factors. Materials are assigned "ranks" based on information available about their unique properties and requirements. From the rank and attribute priorities, values for MCF/DCF can be obtained. Since information available is often limited, the ranks assigned to materials are not highly accurate values. The Monte Carlo simulation technique is used to take away some of the uncertainty in the ranks of the newly developed materials and generate a more "robust" MCF/DCF value. Sensitivity of the method to varying inputs is examined. An attempt is made to compare this practical methodology with two popular approaches, one used for analyzing the complexity of composite materials and another that develops manufacturing complexity factors for given input

  7. The INFN-CNAF Tier-1 GEMSS Mass Storage System and database facility activity

    NASA Astrophysics Data System (ADS)

    Ricci, Pier Paolo; Cavalli, Alessandro; Dell'Agnello, Luca; Favaro, Matteo; Gregori, Daniele; Prosperini, Andrea; Pezzi, Michele; Sapunenko, Vladimir; Zizzi, Giovanni; Vagnoni, Vincenzo

    2015-05-01

    The consolidation of Mass Storage services at the INFN-CNAF Tier1 Storage department that has occurred during the last 5 years, resulted in a reliable, high performance and moderately easy-to-manage facility that provides data access, archive, backup and database services to several different use cases. At present, the GEMSS Mass Storage System, developed and installed at CNAF and based upon an integration between the IBM GPFS parallel filesystem and the Tivoli Storage Manager (TSM) tape management software, is one of the largest hierarchical storage sites in Europe. It provides storage resources for about 12% of LHC data, as well as for data of other non-LHC experiments. Files are accessed using standard SRM Grid services provided by the Storage Resource Manager (StoRM), also developed at CNAF. Data access is also provided by XRootD and HTTP/WebDaV endpoints. Besides these services, an Oracle database facility is in production characterized by an effective level of parallelism, redundancy and availability. This facility is running databases for storing and accessing relational data objects and for providing database services to the currently active use cases. It takes advantage of several Oracle technologies, like Real Application Cluster (RAC), Automatic Storage Manager (ASM) and Enterprise Manager centralized management tools, together with other technologies for performance optimization, ease of management and downtime reduction. The aim of the present paper is to illustrate the state-of-the-art of the INFN-CNAF Tier1 Storage department infrastructures and software services, and to give a brief outlook to forthcoming projects. A description of the administrative, monitoring and problem-tracking tools that play a primary role in managing the whole storage framework is also given.

  8. Gold and diazo reagents: a fruitful tool for developing molecular complexity.

    PubMed

    Fructos, Manuel R; Díaz-Requejo, M Mar; Pérez, Pedro J

    2016-06-11

    Since the discovery in 2005 of the potential of soluble Au complexes to catalyse the transfer of carbene groups from diazo compounds to organic substrates, an increasing number of transformations have been reported. In this contribution, the advances in the field are presented as foundations for further developments in the incoming years.

  9. Evaluating Long-Term Complex Professional Development: Using a Variation of the Cohort Control Design

    ERIC Educational Resources Information Center

    Sample Mcmeeking, Laura B.; Cobb, R. Brian; Basile, Carole

    2010-01-01

    This paper introduces a variation on the post-test only cohort control design and addresses questions concerning both the methodological credibility and the practical utility of employing this design variation in evaluations of large-scale complex professional development programmes in mathematics education. The original design and design…

  10. Peer Conflict Explanations in Children, Adolescents, and Adults: Examining the Development of Complex Syntax

    ERIC Educational Resources Information Center

    Nippold, Marilyn A.; Mansfield, Tracy C.; Billow, Jesse L.

    2007-01-01

    Purpose: Expository discourse, the use of language to convey information, requires facility with complex syntax. Although expository discourse is often employed in school and work settings, little is known about its development in children, adolescents, and adults. Hence, it is difficult to evaluate this genre in students who have language…

  11. Developing and Modeling Complex Social Interventions: Introducing the Connecting People Intervention

    ERIC Educational Resources Information Center

    Webber, Martin; Reidy, Hannah; Ansari, David; Stevens, Martin; Morris, David

    2016-01-01

    Objectives: Modeling the processes involved in complex social interventions is important in social work practice, as it facilitates their implementation and translation into different contexts. This article reports the process of developing and modeling the connecting people intervention (CPI), a model of practice that supports people with mental…

  12. 2D and 3D Method of Characteristic Tools for Complex Nozzle Development

    NASA Technical Reports Server (NTRS)

    Rice, Tharen

    2003-01-01

    This report details the development of a 2D and 3D Method of Characteristic (MOC) tool for the design of complex nozzle geometries. These tools are GUI driven and can be run on most Windows-based platforms. The report provides a user's manual for these tools as well as explains the mathematical algorithms used in the MOC solutions.

  13. Developing Complex Interventions for Rigorous Evaluation--A Case Study from Rural Zimbabwe

    ERIC Educational Resources Information Center

    Power, R.; Langhaug, L. F.; Nyamurera, T.; Wilson, D.; Bassett, M. T.; Cowan, F. M.

    2004-01-01

    Much attention has been placed on the need to develop and evaluate complex interventions targeting public health issues, such as reproductive health. However, and as has been the case in the recent past, even well-designed trials will be flawed unless meticulous attention is paid to ensuring the most appropriate intervention is designed and…

  14. Future Development Of The Flerov Laboratory Accelerator Complex (Project DRIBs-III)

    NASA Astrophysics Data System (ADS)

    Gulbekian, G. G.; Dmitriev, S. N.; Itkis, M. G.; Oganessian, Yu. Ts.; Popeko, A. G.

    2010-04-01

    Future development of the FLNR accelerator complex (project DRIBs-III) includes modernization of existing cyclotrons, construction of a new experimental hall, creation of a new high current cyclotron and of next generation experimental set-ups. Realization of the project is planned for 2010-2016.

  15. Complexity, Accuracy and Fluency: The Role Played by Formulaic Sequences in Early Interlanguage Development

    ERIC Educational Resources Information Center

    Myles, Florence

    2012-01-01

    The purpose of this chapter is to investigate how complexity, accuracy and fluency interact in early L2 development, when learners' linguistic means are underdeveloped. Learners then resort to rote-learned formulaic sequences to complement their current grammar when it is unable to meet their communicative needs. The interplay between their…

  16. Syntactical Complexity in Written Language and Cognitive Development at the Formal Level.

    ERIC Educational Resources Information Center

    Lawson, Anton E.; Shepherd, Gene D.

    1979-01-01

    Investigated the relationship between syntactical complexity of high school students' written language and their ability to reason formally. Format reasoning ability of 50 high school students was measured by a 15-item group-administered demonstration test developed by Lawson. (HM)

  17. The Complex Learning Difficulties and Disabilities Research Project: Developing Meaningful Pathways to Personalised Learning. Final Report

    ERIC Educational Resources Information Center

    Schools Network, 2011

    2011-01-01

    The Specialist Schools and Academies Trust (SSAT) was commissioned by the Department for Education (DfE) to research ways to improve outcomes for children and young people with the most complex educational needs and disabilities through the development of evidence-based teaching and learning strategies. The programme of research brought together a…

  18. The Complex Learning Difficulties and Disabilities Research Project: Developing Meaningful Pathways to Personalised Learning. Executive Summary

    ERIC Educational Resources Information Center

    Schools Network, 2011

    2011-01-01

    The Specialist Schools and Academies Trust (SSAT) was commissioned by the Department for Education (DfE) to research ways to improve outcomes for children and young people with the most complex educational needs and disabilities through the development of evidence-based teaching and learning strategies. The programme of research brought together a…

  19. Methodology development for the sustainability process assessment of sheet metal forming of complex-shaped products

    NASA Astrophysics Data System (ADS)

    Pankratov, D. L.; Kashapova, L. R.

    2015-06-01

    A methodology was developed for automated assessment of the reliability of the process of sheet metal forming process to reduce the defects in complex components manufacture. The article identifies the range of allowable values of the stamp parameters to obtain defect-free punching of spars trucks.

  20. Phase Transitions in Development of Writing Fluency from a Complex Dynamic Systems Perspective

    ERIC Educational Resources Information Center

    Baba, Kyoko; Nitta, Ryo

    2014-01-01

    This study explored patterns in L2 writing development by focusing on one of the linguistic features of texts (fluency) from a complex dynamic systems perspective. It investigated whether two English-as-a-foreign-language university students would experience discontinuous change (phase transition) in their writing fluency through repetition of a…

  1. Should We Use Characteristics of Conversation to Measure Grammatical Complexity in L2 Writing Development?

    ERIC Educational Resources Information Center

    Biber, Douglas; Gray, Bethany; Poonpon, Kornwipa

    2011-01-01

    Studies of L2 writing development usually measure T-units and clausal subordination to assess grammatical complexity, assuming that increased subordination is typical of advanced writing. In this article we challenge this practice by showing that these measures are much more characteristic of conversation than academic writing. The article begins…

  2. The Development of Complex Problem Solving in Adolescence: A Latent Growth Curve Analysis

    ERIC Educational Resources Information Center

    Frischkorn, Gidon T.; Greiff, Samuel; Wüstenberg, Sascha

    2014-01-01

    Complex problem solving (CPS) as a cross-curricular competence has recently attracted more attention in educational psychology as indicated by its implementation in international educational large-scale assessments such as the Programme for International Student Assessment. However, research on the development of CPS is scarce, and the few…

  3. To Wait in Tier 1 or Intervene Immediately: A Randomized Experiment Examining First Grade Response to Intervention (RTI) in Reading

    ERIC Educational Resources Information Center

    Al Otaiba, Stephanie; Connor, Carol M.; Folsom, Jessica S.; Wanzek, Jeanne; Greulich, Luana; Schatschneider, Christopher; Wagner, Richard K.

    2015-01-01

    This randomized control study compares the efficacy of two response-to-intervention (RTI) models: (1) Dynamic RTI, which immediately refers grade 1 students with the weakest skills to the most intensive intervention supports (Tier 2 or Tier 3); and (2) Typical RTI, which starts all students in Tier 1 and after 8 weeks, decides whether students who…

  4. 75 FR 51331 - Draft Tier II Environmental Impact Statement: Southeast High Speed Rail Corridor-Richmond, VA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-19

    ... Federal Railroad Administration Draft Tier II Environmental Impact Statement: Southeast High Speed Rail... the Tier II Draft Environmental Impact Statement for the Southeast High Speed Rail, Richmond, VA to... the Draft Tier II Environmental Impact Statement for the Southeast High Speed Rail, Richmond, VA...

  5. 78 FR 20881 - Control of Air Pollution From Motor Vehicles: Tier 3 Motor Vehicle Emission and Fuel Standards...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-08

    ... AGENCY 40 CFR Part 80 RIN 2060-AQ86 Control of Air Pollution From Motor Vehicles: Tier 3 Motor Vehicle... hearings to be held for the proposed rule ``Control of Air Pollution from Motor Vehicles: Tier 3 Motor Vehicle Emission and Fuel Standards'' (the proposed rule is hereinafter referred to as ``Tier 3''),...

  6. Examining the Predictive Validity of a Dynamic Assessment of Decoding to Forecast Response to Tier 2 Intervention

    ERIC Educational Resources Information Center

    Cho, Eunsoo; Compton, Donald L.; Fuchs, Douglas; Fuchs, Lynn S.; Bouton, Bobette

    2014-01-01

    The purpose of this study was to examine the role of a dynamic assessment (DA) of decoding in predicting responsiveness to Tier 2 small-group tutoring in a response-to-intervention model. First grade students (n = 134) who did not show adequate progress in Tier 1 based on 6 weeks of progress monitoring received Tier 2 small-group tutoring in…

  7. Development of the aza-crown ether metal complexes as artificial hydrolase.

    PubMed

    Yu, Lan; Li, Fang-zhen; Wu, Jiao-yi; Xie, Jia-qing; Li, Shuo

    2016-01-01

    Hydrolases play a crucial role in the biochemical process, which can catalyze the hydrolysis of various compounds like carboxylic esters, phosphoesters, amides, nucleic acids, peptides, and so on. The design of artificial hydrolases has attracted extensive attention due to their scientific significance and potential applications in the field of gene medicine and molecular biology. Numerous macrocyclic metal complexes have been used as artificial hydrolase in the catalytic hydrolysis of the organic substrate. Aza-crown ether for this comment is a special class of the macrocyclic ligand containing both the nitrogen atoms and oxygen atoms in the ring. The studies showed that the aza-crown complexes exhibited high activity of hydrolytic enzyme. However, the aza-crown ether metal complex as artificial hydrolase is still very limited because of its difficulty in synthesis. This review summarizes the development of the aza-crown ether metal complexes as the artificial hydrolase, including the synthesis and catalysis of the transition metal complexes and lanthanide metal complexes of aza-crown ethers. The purpose of this review is to highlight: (1) the relationship between the structure and hydrolytic activity of synthetic hydrolase; (2) the synergistic effect of metal sites and ligands in the course of organic compound hydrolysis; and (3) the design strategies of the aza-crown ethers as hydrolase. PMID:26460062

  8. [Development of complex enzymatic preparations of pactinases and celulases for sugar beet marc digestion].

    PubMed

    Bushina, E V; Rozhkova, A M; Zorov, I N; Satrutdinov, A D; Bekkarevich, A O; Koshelev, A V; Okunev, O N; Sinitsyn, A P

    2012-01-01

    Complex enzymatic preparations demonstrating activities homologous to pectinlyase A and heterologous to endo-1,4-beta-glucanase from Penicilliumverruculosum and beta-glycosidase from Aspergillusniger have been obtained on the basis of recombinant strains of the fungus Penicilliumcanescens. Two approaches were utilized: development of an enzymatic preparation on the basis of a new strain, which produced all three enzymes, and development of an enzymatic preparation via combined cultivation of three strains, each of which produced one of the enzymes.

  9. A Project Management Approach to Using Simulation for Cost Estimation on Large, Complex Software Development Projects

    NASA Technical Reports Server (NTRS)

    Mizell, Carolyn; Malone, Linda

    2007-01-01

    It is very difficult for project managers to develop accurate cost and schedule estimates for large, complex software development projects. None of the approaches or tools available today can estimate the true cost of software with any high degree of accuracy early in a project. This paper provides an approach that utilizes a software development process simulation model that considers and conveys the level of uncertainty that exists when developing an initial estimate. A NASA project will be analyzed using simulation and data from the Software Engineering Laboratory to show the benefits of such an approach.

  10. Who Is Worst Off? Developing a Severity-scoring Model of Complex Emergency Affected Countries in Order to Ensure Needs Based Funding

    PubMed Central

    Eriksson, Anneli; Ohlsén, Ylva Kristina; Garfield, Richard; von Schreeb, Johan

    2015-01-01

    Background: Disasters affect close to 400 million people each year. Complex Emergencies (CE) are a category of disaster that affects nearly half of the 400 million and often last for several years. To support the people affected by CE, humanitarian assistance is provided with the aim of saving lives and alleviating suffering. It is widely agreed that funding for this assistance should be needs-based. However, to date, there is no model or set of indicators that quantify and compare needs from one CE to another. In an effort to support needs-based and transparent funding of humanitarian assistance, the aim of this study is to develop a model that distinguishes between levels of severity among countries affected by CE. Methods: In this study, severity serves as a predictor for level of need. The study focuses on two components of severity: vulnerability and exposure. In a literature and Internet search we identified indicators that characterize vulnerability and exposure to CE. Among the more than 100 indicators identified, a core set of six was selected in an expert ratings exercise. Selection was made based on indicator availability and their ability to characterize preexisting or underlying vulnerabilities (four indicators) or to quantify exposure to a CE (two indicators). CE from 50 countries were then scored using a 3-tiered score (Low-Moderate, High, Critical).  Results: The developed model builds on the logic of the Utstein template. It scores severity based on the readily available value of four vulnerability and four exposure indicators. These are 1) GNI per capita, PPP, 2) Under-five mortality rate, per 1 000 live births, 3) Adult literacy rate, % of people ages 15 and above, 4) Underweight, % of population under 5 years, and 5) number of persons and proportion of population affected, and 6) number of uprooted persons and proportion of population uprooted. Conclusion: The model can be used to derive support for transparent, needs-based funding of

  11. On Convergence of Development Costs and Cost Models for Complex Spaceflight Instrument Electronics

    NASA Technical Reports Server (NTRS)

    Kizhner, Semion; Patel, Umeshkumar D.; Kasa, Robert L.; Hestnes, Phyllis; Brown, Tammy; Vootukuru, Madhavi

    2008-01-01

    Development costs of a few recent spaceflight instrument electrical and electronics subsystems have diverged from respective heritage cost model predictions. The cost models used are Grass Roots, Price-H and Parametric Model. These cost models originated in the military and industry around 1970 and were successfully adopted and patched by NASA on a mission-by-mission basis for years. However, the complexity of new instruments recently changed rapidly by orders of magnitude. This is most obvious in the complexity of representative spaceflight instrument electronics' data system. It is now required to perform intermediate processing of digitized data apart from conventional processing of science phenomenon signals from multiple detectors. This involves on-board instrument formatting of computational operands from row data for example, images), multi-million operations per second on large volumes of data in reconfigurable hardware (in addition to processing on a general purpose imbedded or standalone instrument flight computer), as well as making decisions for on-board system adaptation and resource reconfiguration. The instrument data system is now tasked to perform more functions, such as forming packets and instrument-level data compression of more than one data stream, which are traditionally performed by the spacecraft command and data handling system. It is furthermore required that the electronics box for new complex instruments is developed for one-digit watt power consumption, small size and that it is light-weight, and delivers super-computing capabilities. The conflict between the actual development cost of newer complex instruments and its electronics components' heritage cost model predictions seems to be irreconcilable. This conflict and an approach to its resolution are addressed in this paper by determining the complexity parameters, complexity index, and their use in enhanced cost model.

  12. How and when Does Complex Reasoning Occur? Empirically Driven Development of a Learning Progression Focused on Complex Reasoning about Biodiversity

    ERIC Educational Resources Information Center

    Songer, Nancy Butler; Kelcey, Ben; Gotwals, Amelia Wenk

    2009-01-01

    In order to compete in a global economy, students are going to need resources and curricula focusing on critical thinking and reasoning in science. Despite awareness for the need for complex reasoning, American students perform poorly relative to peers on international standardized tests measuring complex thinking in science. Research focusing on…

  13. Quantitative assessment of Hox complex expression in the indirect development of the polychaete annelid Chaetopterus sp

    NASA Technical Reports Server (NTRS)

    Peterson, K. J.; Irvine, S. Q.; Cameron, R. A.; Davidson, E. H.

    2000-01-01

    A prediction from the set-aside theory of bilaterian origins is that pattern formation processes such as those controlled by the Hox cluster genes are required specifically for adult body plan formation. This prediction can be tested in animals that use maximal indirect development, in which the embryonic formation of the larva and the postembryonic formation of the adult body plan are temporally and spatially distinct. To this end, we quantitatively measured the amount of transcripts for five Hox genes in embryos of a lophotrochozoan, the polychaete annelid Chaetopterus sp. The polychaete Hox complex is shown not to be expressed during embryogenesis, but transcripts of all measured Hox complex genes are detected at significant levels during the initial stages of adult body plan formation. Temporal colinearity in the sequence of their activation is observed, so that activation follows the 3'-5' arrangement of the genes. Moreover, Hox gene expression is spatially localized to the region of teloblastic set-aside cells of the later-stage embryos. This study shows that an indirectly developing lophotrochozoan shares with an indirectly developing deuterostome, the sea urchin, a common mode of Hox complex utilization: construction of the larva, whether a trochophore or dipleurula, does not involve Hox cluster expression, but in both forms the complex is expressed in the set-aside cells from which the adult body plan derives.

  14. Developing a framework for qualitative engineering: Research in design and analysis of complex structural systems

    NASA Technical Reports Server (NTRS)

    Franck, Bruno M.

    1990-01-01

    The research is focused on automating the evaluation of complex structural systems, whether for the design of a new system or the analysis of an existing one, by developing new structural analysis techniques based on qualitative reasoning. The problem is to identify and better understand: (1) the requirements for the automation of design, and (2) the qualitative reasoning associated with the conceptual development of a complex system. The long-term objective is to develop an integrated design-risk assessment environment for the evaluation of complex structural systems. The scope of this short presentation is to describe the design and cognition components of the research. Design has received special attention in cognitive science because it is now identified as a problem solving activity that is different from other information processing tasks (1). Before an attempt can be made to automate design, a thorough understanding of the underlying design theory and methodology is needed, since the design process is, in many cases, multi-disciplinary, complex in size and motivation, and uses various reasoning processes involving different kinds of knowledge in ways which vary from one context to another. The objective is to unify all the various types of knowledge under one framework of cognition. This presentation focuses on the cognitive science framework that we are using to represent the knowledge aspects associated with the human mind's abstraction abilities and how we apply it to the engineering knowledge and engineering reasoning in design.

  15. Feature-Dependent Sensitive Periods in the Development of Complex Sound Representation

    PubMed Central

    Insanally, Michele N.; Köver, Hania; Kim, Heesoo; Bao, Shaowen

    2009-01-01

    Simple tonal stimuli can shape spectral tuning of cortical neurons during an early epoch of brain development. The effects of complex sound experience on cortical development remain to be determined. We exposed rat pups to a frequency-modulated (FM) sweep in different time windows during early development, and examined the effects of such sensory experience on sound representations in the primary auditory cortex (AI). We found that early exposure to a FM sound resulted in altered characteristic frequency (CF) representations and broadened spectral tuning in AI neurons, whereas later exposure to the same sound only led to greater selectivity for the sweep rate and direction of the experienced FM sound. These results indicate that cortical representations of different acoustic features are shaped by complex sounds in a series of distinct sensitive periods. PMID:19403813

  16. Determining the Area of Review (AoR) in Carbon Capture and Storage: A tiered, probabilistic methodology to generate risk map

    NASA Astrophysics Data System (ADS)

    Cihan, A.; Siirila-Woodburn, E. R.; Birkholzer, J. T.

    2015-12-01

    The effects and related risks to potable aquifers due to pressure increases and brine leakage through abandoned wells is a poorly understood phenomena and a potentially significant contributor to the risk profile in Geologic Carbon Capture and Storage. Numerical models are used to investigate the evolution of brine leakage (during and post-injection) through wells located in the region where plugged and abandoned (P&A) wellbores leakage could occur. This area, termed tier 3, builds on a 3-tier methodology to define the Area of Review (AoR) proposed by Birkholzer et al. (2013). This work, in conjunction with a quantitative assessment of tier 1 AoR (an area encompassing the CO2 plume) and tier 2 AoR (an are encompassing the extent where open well-bore brine leakage could occur), will lead to a quantitative understanding of potential risks and a metric for the complete spatial extent of environmental risk in Carbon Capture and Storage. Here, we develop a probabilistic methodology to generate "risk maps" related to tier 3 AoR. The risk maps are based on the premise that the two greatest sources of uncertainty in P&A leakage are 1) the location of the unknown well with respect to the injection well and 2) the permeability of the leaky P&A (which can span over several orders of magnitude). The methodology utilizes numerical simulations and probability theory to generate spatial distributions of risk, defined with no-impact or MCL thresholds. Probabilistic risk maps can be used to provide risk-based descriptions of the AoR to inform site selection and monitoring during and post-injection.

  17. Leveraging The Open Provenance Model as a Multi-Tier Model for Global Climate Research

    SciTech Connect

    Stephan, Eric G.; Halter, Todd D.; Ermold, Brian D.

    2010-12-08

    Global climate researchers rely upon many forms of sensor data and analytical methods to help profile subtle changes in climate conditions. The U.S. Department of Energy's Atmospheric Radiation Measurement (ARM) program provides researchers with curated Value Added Products (VAPs) resulting from continuous sensor data streams, data fusion, and modeling. The ARM operations staff and software development teams (data producers) rely upon a number of techniques to ensure strict quality control (QC) and quality assurance (QA) standards are maintained. Climate researchers (data consumers) are highly interested in obtaining as much provenance (data quality, data pedigree) as possible to establish data trustworthiness. Currently all the provenance is not easily attainable or identifiable without significant efforts to extract and piece together information from configuration files, log files, codes, and status information from ARM databases. The need for a formalized approach to managing provenance became paramount with the planned addition of 120 new instruments, new data products, and data collection scaling to half a terabyte daily. Last year our research identified the need for a multi-tier provenance model to enable the data consumer easy access to the provenance for their data. This year we are leveraging the Open Provenance Model as a foundational construct that serves the needs of both the VAP producers and consumers, we are organizing the provenance in different tiers of granularity to model VAP lineage, causality at the component level within a VAP, and the causality for each time step as samples are being assembled within the VAP. This paper shares our implementation strategy and how the ARM operations staff and the climate research community can greatly benefit from this approach to more effectively assess and quantify VAP provenance.

  18. Development of a growth-hormone-conjugated nanodiamond complex for cancer therapy.

    PubMed

    Chu, Hsueh-Liang; Chen, Hung-Wei; Tseng, Shin-Hua; Hsu, Ming-Hua; Ho, Li-Ping; Chou, Fu-Hsuan; Li, Md Phd Hsing-Yuan; Chang, Yu-Chuan; Chen, Pei-Hsin; Tsai, Li-Yun; Chou, Ching-Chung; Chen, Jyh Shin; Cheng, Tsai-Mu; Chang, Chia-Ching

    2014-05-01

    It is highly desirable to develop a therapeutic, observable nanoparticle complex for specific targeting in cancer therapy. Growth hormone (GH) and its antagonists have been explored as cancer cell-targeting molecules for both imaging and therapeutic applications. In this study, a low toxicity, biocompatible, therapeutic, and observable GH-nanoparticle complex for specifically targeting growth hormone receptor (GHR) in cancer cells was synthesized by conjugating GH with green fluorescence protein and carboxylated nanodiamond. Moreover, we have shown that this complex can be triggered by laser irradiation to create a "nanoblast" and induce cell death in the A549 non-small-cell lung cancer cell line via the apoptotic pathway. This laser-mediated, cancer-targeting platform can be widely used in cancer therapy.

  19. Coarse-Grained Structure-Based Model for RNA-Protein Complexes Developed by Fluctuation Matching.

    PubMed

    Hori, Naoto; Takada, Shoji

    2012-09-11

    RNA and RNA-protein complexes have recently been intensively studied in experiments, but the corresponding molecular simulation work is much less abundant, primarily due to its large system size and the long time scale involved. Here, to overcome these bottlenecks, we develop a coarse-grained (CG) structure-based simulation model for RNA and RNA-protein complexes and test it for several molecular systems. The CG model for RNA contains three particles per nucleotide, each for phosphate, sugar, and a base. Focusing on RNA molecules that fold to well-defined native structures, we employed a structure-based potential, which is similar to the Go-like potential successfully used in CG modeling of proteins. In addition, we tested three means to approximate electrostatic interactions. Many parameters involved in the CG potential were determined via a multiscale method: We matched the native fluctuation of the CG model with that by all-atom simulations for 16 RNA molecules and 10 RNA-protein complexes, from which we derived a generic set of CG parameters. We show that the derived parameters can reproduce native fluctuations well for four RNA and two RNA-protein complexes. For tRNA, the native fluctuation in solution includes large-amplitude motions that reach conformations nearly corresponding to the hybrid state P/E and EF-Tu-bound state A/T seen in the complexes with ribosome. Finally, large-amplitude modes of ribosome are briefly described.

  20. DNA-osmium complexes: recent developments in the operative chemical analysis of DNA epigenetic modifications.

    PubMed

    Okamoto, Akimitsu

    2014-09-01

    The development of a reaction for the detection of one epigenetic modification in a long DNA strand is a chemically and biologically challenging research subject. Herein, we report and discuss the formation of 5-methylcytosine-osmium complexes that are used as the basis for a bisulfite-free chemical assay for DNA methylation analysis. Osmium in the oxidized state reacts with C5-methylated pyrimidines in the presence of a bipyridine ligand to give a stable ternary complex. On the basis of this reaction, an adenine derivative with a tethered bipyridine moiety has been designed for sequence-specific osmium complex formation. Osmium complexation is then achieved by hybridization of a short DNA molecule containing this functional nucleotide to a target DNA sequence and results in the formation of a cross-linked structure. This novel concept of methylation-specific reaction, based on a straightforward chemical process, expands the range of methods available for the analysis of epigenetic modifications. Advantages of the described method include amplification-insensitive detection, 5-hydroxymethylcytosine complexation, and visualization through methylation-specific in situ hybridization.

  1. MADS-Box Protein Complexes Control Carpel and Ovule Development in Arabidopsis

    PubMed Central

    Favaro, Rebecca; Pinyopich, Anusak; Battaglia, Raffaella; Kooiker, Maarten; Borghi, Lorenzo; Ditta, Gary; Yanofsky, Martin F.; Kater, Martin M.; Colombo, Lucia

    2003-01-01

    The AGAMOUS (AG) gene is necessary for stamen and carpel development and is part of a monophyletic clade of MADS-box genes that also includes SHATTERPROOF1 (SHP1), SHP2, and SEEDSTICK (STK). Here, we show that ectopic expression of either the STK or SHP gene is sufficient to induce the transformation of sepals into carpeloid organs bearing ovules. Moreover, the fact that these organ transformations occur when the STK gene is expressed ectopically in ag mutants shows that STK can promote carpel development in the absence of AG activity. We also show that STK, AG, SHP1, and SHP2 can form multimeric complexes and that these interactions require the SEPALLATA (SEP) MADS-box proteins. We provide genetic evidence for this role of the SEP proteins by showing that a reduction in SEP activity leads to the loss of normal ovule development, similar to what occurs in stk shp1 shp2 triple mutants. Together, these results indicate that the SEP proteins, which are known to form multimeric complexes in the control of flower organ identity, also form complexes to control normal ovule development. PMID:14555696

  2. Student Cognitive Difficulties and Mental Model Development of Complex Earth and Environmental Systems

    NASA Astrophysics Data System (ADS)

    Sell, K.; Herbert, B.; Schielack, J.

    2004-05-01

    Students organize scientific knowledge and reason about environmental issues through manipulation of mental models. The nature of the environmental sciences, which are focused on the study of complex, dynamic systems, may present cognitive difficulties to students in their development of authentic, accurate mental models of environmental systems. The inquiry project seeks to develop and assess the coupling of information technology (IT)-based learning with physical models in order to foster rich mental model development of environmental systems in geoscience undergraduate students. The manipulation of multiple representations, the development and testing of conceptual models based on available evidence, and exposure to authentic, complex and ill-constrained problems were the components of investigation utilized to reach the learning goals. Upper-level undergraduate students enrolled in an environmental geology course at Texas A&M University participated in this research which served as a pilot study. Data based on rubric evaluations interpreted by principal component analyses suggest students' understanding of the nature of scientific inquiry is limited and the ability to cross scales and link systems proved problematic. Results categorized into content knowledge and cognition processes where reasoning, critical thinking and cognitive load were driving factors behind difficulties in student learning. Student mental model development revealed multiple misconceptions and lacked complexity and completeness to represent the studied systems. Further, the positive learning impacts of the implemented modules favored the physical model over the IT-based learning projects, likely due to cognitive load issues. This study illustrates the need to better understand student difficulties in solving complex problems when using IT, where the appropriate scaffolding can then be implemented to enhance student learning of the earth system sciences.

  3. Statistical Techniques Complement UML When Developing Domain Models of Complex Dynamical Biosystems.

    PubMed

    Williams, Richard A; Timmis, Jon; Qwarnstrom, Eva E

    2016-01-01

    Computational modelling and simulation is increasingly being used to complement traditional wet-lab techniques when investigating the mechanistic behaviours of complex biological systems. In order to ensure computational models are fit for purpose, it is essential that the abstracted view of biology captured in the computational model, is clearly and unambiguously defined within a conceptual model of the biological domain (a domain model), that acts to accurately represent the biological system and to document the functional requirements for the resultant computational model. We present a domain model of the IL-1 stimulated NF-κB signalling pathway, which unambiguously defines the spatial, temporal and stochastic requirements for our future computational model. Through the development of this model, we observe that, in isolation, UML is not sufficient for the purpose of creating a domain model, and that a number of descriptive and multivariate statistical techniques provide complementary perspectives, in particular when modelling the heterogeneity of dynamics at the single-cell level. We believe this approach of using UML to define the structure and interactions within a complex system, along with statistics to define the stochastic and dynamic nature of complex systems, is crucial for ensuring that conceptual models of complex dynamical biosystems, which are developed using UML, are fit for purpose, and unambiguously define the functional requirements for the resultant computational model. PMID:27571414

  4. Statistical Techniques Complement UML When Developing Domain Models of Complex Dynamical Biosystems.

    PubMed

    Williams, Richard A; Timmis, Jon; Qwarnstrom, Eva E

    2016-01-01

    Computational modelling and simulation is increasingly being used to complement traditional wet-lab techniques when investigating the mechanistic behaviours of complex biological systems. In order to ensure computational models are fit for purpose, it is essential that the abstracted view of biology captured in the computational model, is clearly and unambiguously defined within a conceptual model of the biological domain (a domain model), that acts to accurately represent the biological system and to document the functional requirements for the resultant computational model. We present a domain model of the IL-1 stimulated NF-κB signalling pathway, which unambiguously defines the spatial, temporal and stochastic requirements for our future computational model. Through the development of this model, we observe that, in isolation, UML is not sufficient for the purpose of creating a domain model, and that a number of descriptive and multivariate statistical techniques provide complementary perspectives, in particular when modelling the heterogeneity of dynamics at the single-cell level. We believe this approach of using UML to define the structure and interactions within a complex system, along with statistics to define the stochastic and dynamic nature of complex systems, is crucial for ensuring that conceptual models of complex dynamical biosystems, which are developed using UML, are fit for purpose, and unambiguously define the functional requirements for the resultant computational model.

  5. Statistical Techniques Complement UML When Developing Domain Models of Complex Dynamical Biosystems

    PubMed Central

    Timmis, Jon; Qwarnstrom, Eva E.

    2016-01-01

    Computational modelling and simulation is increasingly being used to complement traditional wet-lab techniques when investigating the mechanistic behaviours of complex biological systems. In order to ensure computational models are fit for purpose, it is essential that the abstracted view of biology captured in the computational model, is clearly and unambiguously defined within a conceptual model of the biological domain (a domain model), that acts to accurately represent the biological system and to document the functional requirements for the resultant computational model. We present a domain model of the IL-1 stimulated NF-κB signalling pathway, which unambiguously defines the spatial, temporal and stochastic requirements for our future computational model. Through the development of this model, we observe that, in isolation, UML is not sufficient for the purpose of creating a domain model, and that a number of descriptive and multivariate statistical techniques provide complementary perspectives, in particular when modelling the heterogeneity of dynamics at the single-cell level. We believe this approach of using UML to define the structure and interactions within a complex system, along with statistics to define the stochastic and dynamic nature of complex systems, is crucial for ensuring that conceptual models of complex dynamical biosystems, which are developed using UML, are fit for purpose, and unambiguously define the functional requirements for the resultant computational model. PMID:27571414

  6. Increasing quality and managing complexity in neuroinformatics software development with continuous integration

    PubMed Central

    Zaytsev, Yury V.; Morrison, Abigail

    2013-01-01

    High quality neuroscience research requires accurate, reliable and well maintained neuroinformatics applications. As software projects become larger, offering more functionality and developing a denser web of interdependence between their component parts, we need more sophisticated methods to manage their complexity. If complexity is allowed to get out of hand, either the quality of the software or the speed of development suffer, and in many cases both. To address this issue, here we develop a scalable, low-cost and open source solution for continuous integration (CI), a technique which ensures the quality of changes to the code base during the development procedure, rather than relying on a pre-release integration phase. We demonstrate that a CI-based workflow, due to rapid feedback about code integration problems and tracking of code health measures, enabled substantial increases in productivity for a major neuroinformatics project and additional benefits for three further projects. Beyond the scope of the current study, we identify multiple areas in which CI can be employed to further increase the quality of neuroinformatics projects by improving development practices and incorporating appropriate development tools. Finally, we discuss what measures can be taken to lower the barrier for developers of neuroinformatics applications to adopt this useful technique. PMID:23316158

  7. A key management scheme for tiered wireless sensor network with self-healing capability

    NASA Astrophysics Data System (ADS)

    Wang, Maoyu; Tang, Helen; Yu, F. R.

    2013-05-01

    This paper presents a novel key management scheme for a tiered self-healing wireless sensor network. A tiered wireless sensor network with self-healing features draws extensive attention because of its scalability, robustness and reliability. A tiered key management scheme to support the cluster membership and the self-healing features is proposed with emphasis on the control of a node's participation and re-keying when joining a new cluster. The security and overhead analysis demonstrates the proposed scheme is effective and efficient with respect to communication, computation, and memory overhead for operation in a hostile environment.

  8. Development and evaluation of a musculoskeletal model of the elbow joint complex

    NASA Technical Reports Server (NTRS)

    Gonzalez, Roger V.; Hutchins, E. L.; Barr, Ronald E.; Abraham, Lawrence D.

    1993-01-01

    This paper describes the development and evaluation of a musculoskeletal model that represents human elbow flexion-extension and forearm pronation-supination. The length, velocity, and moment arm for each of the eight musculotendon actuators were based on skeletal anatomy and position. Musculotendon parameters were determined for each actuator and verified by comparing analytical torque-angle curves with experimental joint torque data. The parameters and skeletal geometry were also utilized in the musculoskeletal model for the analysis of ballistic elbow joint complex movements. The key objective was to develop a computational model, guided by parameterized optimal control, to investigate the relationship among patterns of muscle excitation, individual muscle forces, and movement kinematics. The model was verified using experimental kinematic, torque, and electromyographic data from volunteer subjects performing ballistic elbow joint complex movements.

  9. [The economic-industrial health care complex and the social and economic dimension of development].

    PubMed

    Gadelha, Carlos Augusto Grabois; Costa, Laís Silveira; Maldonado, José

    2012-12-01

    The strategic role of health care in the national development agenda has been increasingly recognized and institutionalized. In addition to its importance as a structuring element of the Social Welfare State, health care plays a leading role in the generation of innovation - an essential element for competitiveness in knowledge society. However, health care's productive basis is still fragile, and this negatively affects both the universal provision of health care services and Brazil's competitive inclusion in the globalized environment. This situation suggests the need of a more systematic analysis of the complex relationships among productive, technological and social interests in the scope of health care. Consequently, it is necessary to produce further knowledge about the Economic-Industrial Health Care Complex due to its potential for contributing to a socially inclusive development model. This means reversing the hierarchy between economic and social interests in the sanitary field, thus minimizing the vulnerability of the Brazilian health care policy.

  10. Developing strongly luminescent platinum(IV) complexes: facile synthesis of bis-cyclometalated neutral emitters.

    PubMed

    Juliá, Fabio; Bautista, Delia; González-Herrero, Pablo

    2016-01-28

    A straightforward, one-pot procedure has been developed for the synthesis of bis-cyclometalated chloro(methyl)platinum(IV) complexes with a wide variety of heteroaromatic ligands of the 2-arylpyridine type. The new compounds exhibit phosphorescent emissions in the blue to orange colour range and represent the most efficient Pt(IV) emitters reported to date, with quantum yields up to 0.81 in fluid solutions at room temperature.

  11. Peripheral ameloblastic fibro-odontoma or peripheral developing complex odontoma: report of a case.

    PubMed

    Reibel, Jesper; Grønbaek, Anni B; Poulsen, Sven

    2011-11-01

    BACKGROUND. Peripheral (extraosseous) odontogenic tumors are rare. CASE REPORT. This report describes a case which illustrates the clinical and histopathological features of a lesion in an 8-year-old, healthy Caucasian girl that on purely morphological grounds would seem to be an ameloblastic fibro-odontoma, but may represent a case of a peripheral developing complex odontoma. CONCLUSION. Conservative surgical enucleation of the lesion was followed by unbcomplicated healing and no recurrence was seen.

  12. Development and evaluation of a predictive algorithm for telerobotic task complexity

    NASA Technical Reports Server (NTRS)

    Gernhardt, M. L.; Hunter, R. C.; Hedgecock, J. C.; Stephenson, A. G.

    1993-01-01

    There is a wide range of complexity in the various telerobotic servicing tasks performed in subsea, space, and hazardous material handling environments. Experience with telerobotic servicing has evolved into a knowledge base used to design tasks to be 'telerobot friendly.' This knowledge base generally resides in a small group of people. Written documentation and requirements are limited in conveying this knowledge base to serviceable equipment designers and are subject to misinterpretation. A mathematical model of task complexity based on measurable task parameters and telerobot performance characteristics would be a valuable tool to designers and operational planners. Oceaneering Space Systems and TRW have performed an independent research and development project to develop such a tool for telerobotic orbital replacement unit (ORU) exchange. This algorithm was developed to predict an ORU exchange degree of difficulty rating (based on the Cooper-Harper rating used to assess piloted operations). It is based on measurable parameters of the ORU, attachment receptacle and quantifiable telerobotic performance characteristics (e.g., link length, joint ranges, positional accuracy, tool lengths, number of cameras, and locations). The resulting algorithm can be used to predict task complexity as the ORU parameters, receptacle parameters, and telerobotic characteristics are varied.

  13. Nanoscale Reaction Vessels Designed for Synthesis of Copper-Drug Complexes Suitable for Preclinical Development.

    PubMed

    Wehbe, Mohamed; Anantha, Malathi; Backstrom, Ian; Leung, Ada; Chen, Kent; Malhotra, Armaan; Edwards, Katarina; Bally, Marcel B

    2016-01-01

    The development of copper-drug complexes (CDCs) is hindered due to their very poor aqueous solubility. Diethyldithiocarbamate (DDC) is the primary metabolite of disulfiram, an approved drug for alcoholism that is being repurposed for cancer. The anticancer activity of DDC is dependent on complexation with copper to form copper bis-diethyldithiocarbamate (Cu(DDC)2), a highly insoluble complex that has not been possible to develop for indications requiring parenteral administration. We have resolved this issue by synthesizing Cu(DDC)2 inside liposomes. DDC crosses the liposomal lipid bilayer, reacting with the entrapped copper; a reaction that can be observed through a colour change as the solution goes from a light blue to dark brown. This method is successfully applied to other CDCs including the anti-parasitic drug clioquinol, the natural product quercetin and the novel targeted agent CX-5461. Our method provides a simple, transformative solution enabling, for the first time, the development of CDCs as viable candidate anticancer drugs; drugs that would represent a brand new class of therapeutics for cancer patients. PMID:27055237

  14. Nanoscale Reaction Vessels Designed for Synthesis of Copper-Drug Complexes Suitable for Preclinical Development.

    PubMed

    Wehbe, Mohamed; Anantha, Malathi; Backstrom, Ian; Leung, Ada; Chen, Kent; Malhotra, Armaan; Edwards, Katarina; Bally, Marcel B

    2016-01-01

    The development of copper-drug complexes (CDCs) is hindered due to their very poor aqueous solubility. Diethyldithiocarbamate (DDC) is the primary metabolite of disulfiram, an approved drug for alcoholism that is being repurposed for cancer. The anticancer activity of DDC is dependent on complexation with copper to form copper bis-diethyldithiocarbamate (Cu(DDC)2), a highly insoluble complex that has not been possible to develop for indications requiring parenteral administration. We have resolved this issue by synthesizing Cu(DDC)2 inside liposomes. DDC crosses the liposomal lipid bilayer, reacting with the entrapped copper; a reaction that can be observed through a colour change as the solution goes from a light blue to dark brown. This method is successfully applied to other CDCs including the anti-parasitic drug clioquinol, the natural product quercetin and the novel targeted agent CX-5461. Our method provides a simple, transformative solution enabling, for the first time, the development of CDCs as viable candidate anticancer drugs; drugs that would represent a brand new class of therapeutics for cancer patients.

  15. Development of a General Modeling Framework for Investigating Complex Interactions among Biological and Physical Ecosystem Dynamics

    NASA Astrophysics Data System (ADS)

    Bennett, C.; Poole, G. C.; Kimball, J. S.; Stanford, J. A.; O'Daniel, S. J.; Mertes, L. A.

    2005-05-01

    Historically, physical scientists have developed models with highly accurate governing equations, while biologists have excelled at abstraction (the strategic simplification of system complexity). These different modeling paradigms yield biological (e.g. food web) and physical (e.g. hydrologic) models that can be difficult to integrate. Complex biological dynamics may be impossible to represent with governing equations. Conversely, physical processes may be oversimplified in biological models. Using agent-based modeling, a technique applied widely in social sciences and economics, we are developing a general modeling system to integrate accurate representations of physical dynamics such as water and heat flux with abstracted biological processes such as nutrient transformations. The modeling system represents an ecosystem as a complex integrated network of intelligent physical and biological "agents" that store, transform, and trade ecosystem resources (e.g., water, heat, nutrients, carbon) using equations that describe either abstracted concepts and/or physical laws. The modular design of the system allows resource submodels to be developed independently and installed into the simulation architecture. The modeling system provides a useful heuristic tool to support integrated physical and biological research topics, such as the influence of hydrologic dynamics and spatio-temporal physical heterogeneity on trophic (food web) dynamics and/or nutrient cycling.

  16. SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease.

    PubMed

    Bevilacqua, Ariana; Willis, Monte S; Bultman, Scott J

    2014-01-01

    Our understanding of congenital heart defects has been recently advanced by whole exome sequencing projects, which have identified de novo mutations in many genes encoding epigenetic regulators. Notably, multiple subunits of switching defective/sucrose non-fermenting (SWI/SNF) chromatin-remodeling complexes have been identified as strong candidates underlying these defects because they physically and functionally interact with cardiogenic transcription factors critical to cardiac development, such as TBX5, GATA-4, and NKX2-5. While these studies indicate a critical role of SWI/SNF complexes in cardiac development and congenital heart disease, many exciting new discoveries have identified their critical role in the adult heart in both physiological and pathological conditions involving multiple cell types in the heart, including cardiomyocytes, vascular endothelial cells, pericytes, and neural crest cells. This review summarizes the role of SWI/SNF chromatin-remodeling complexes in cardiac development, congenital heart disease, cardiac hypertrophy, and vascular endothelial cell survival. Although the clinical relevance of SWI/SNF mutations has traditionally been focused primarily on their role in tumor suppression, these recent studies illustrate their critical role in the heart whereby they regulate cell proliferation, differentiation, and apoptosis of cardiac derived cell lines.

  17. Nanoscale Reaction Vessels Designed for Synthesis of Copper-Drug Complexes Suitable for Preclinical Development

    PubMed Central

    Wehbe, Mohamed; Anantha, Malathi; Backstrom, Ian; Leung, Ada; Chen, Kent; Malhotra, Armaan; Edwards, Katarina; Bally, Marcel B.

    2016-01-01

    The development of copper-drug complexes (CDCs) is hindered due to their very poor aqueous solubility. Diethyldithiocarbamate (DDC) is the primary metabolite of disulfiram, an approved drug for alcoholism that is being repurposed for cancer. The anticancer activity of DDC is dependent on complexation with copper to form copper bis-diethyldithiocarbamate (Cu(DDC)2), a highly insoluble complex that has not been possible to develop for indications requiring parenteral administration. We have resolved this issue by synthesizing Cu(DDC)2 inside liposomes. DDC crosses the liposomal lipid bilayer, reacting with the entrapped copper; a reaction that can be observed through a colour change as the solution goes from a light blue to dark brown. This method is successfully applied to other CDCs including the anti-parasitic drug clioquinol, the natural product quercetin and the novel targeted agent CX-5461. Our method provides a simple, transformative solution enabling, for the first time, the development of CDCs as viable candidate anticancer drugs; drugs that would represent a brand new class of therapeutics for cancer patients. PMID:27055237

  18. Going beyond the hero in leadership development: the place of healthcare context, complexity and relationships

    PubMed Central

    Ford, Jackie

    2015-01-01

    There remains a conviction that the torrent of publications and the financial outlay on leadership development will create managers with the skills and characters of perfect leaders, capable of guiding healthcare organisations through the challenges and crises of the 21st century. The focus of much attention continues to be the search for the (illusory) core set of heroic qualities, abilities or competencies that will enable the development of leaders to achieve levels of supreme leadership and organisational performance. This brief commentary adds support to McDonald’s (1) call for recognition of the complexity of the undertaking. PMID:25844391

  19. Development of the nematocyte junctional complex in hydra tentacles in relation to cellular recognition and positioning.

    PubMed

    Novak, P L; Wood, R L

    1983-05-01

    Formation of the nematocyte-battery cell-mesoglea (NBM) junctional complex of hydra was studied. Normal animals were grafted to nematocyte-free animals and the tentacles of the repopulating host were examined by transmission electron microscopy. Migrating nematocytes extend cytoplasmic processes between battery cell myonemes to contact the mesoglea. Tufts of extracellular filaments radiate from the base of the battery cell adjacent to some of these regions of contact. The fascial desmosome of the NBM complex develops from a lateral fusion of macular desmosomes which often lie near a condensation of extracellular filaments. Microtubules within the intervening battery cell process become oriented perpendicularly to form the apposing half of the desmosomal junction and connect it with the hemidesmosomal portion of the NBM complex. These findings suggest that a migrating nematocyte receives environmental cues associated with the mesoglea-battery cell interface which may serve to direct the nematocyte to its definitive position and induce the subsequent formation of the complete NBM complex.

  20. Structural maintenance of chromosome complexes and bone development: the beginning of a wonderful relationship?

    PubMed Central

    Zinder-Cohen, Miri; Karasik, David; Onn, Itay

    2013-01-01

    Bone development depends on environmental, nutritional and hormonal factors. Yet, an ordered and timed activation of genes and their associated molecular pathways are central for the growth and development of healthy bones. The correct expression of genes depends on both cis- and trans-regulatory elements. Of these, the elusive role of chromatin ultrastructure is just beginning to become appreciated. Changes in the higher-order structure of chromatin are affecting the expression of genes in response to intrinsic and environmental signals. Cohesin and condensin are members of the structural maintenance of chromosome (SMC) family of protein complexes, which mediate higher-order chromatin structure by tethering distinct regions of chromatin either inter- or intra-molecularly. In recent years, SMCs had been identified for their function in the regulation of gene expression and developmental processes, whereas malfunction of cohesin or condensin has an impact on human health. However, little is known about the specific roles of SMC complexes in bone development and their possible effect on bone health. Here, we review studies that suggest an intimate link between SMCs and bone development, as well as a plausible effect, direct or indirect, on the bone health. We describe genetic syndromes associated with SMCs with distinctive bone phenotypes and identify links between SMCs and bone-related molecular pathways. Future studies of the relationship between SMCs and bone development will reveal new understandings of both the cellular and molecular roles of SMC complexes and provide new insights into the growth and developmental processes in the bone. PMID:24422108