Genetic Factors in Breast Cancer: Center for Interdisciplinary Biobehavioral Research

DTIC Science & Technology

2008-10-01

Acculturative stress, depression, and suicidal ideation among immigrant and second-generation Latino adolescents . J Am Acad Child Adolesc Psychiatry 1996;35:1183...Sciences (D. Reich). The Los Angeles Component of the Women’s Contraceptive and Reproductive Experiences Study was supported by a contract from the...Component of the Women’s Contraceptive and Reproductive Experiences Study. A population-based case control study that included African American and

12 CFR Appendix A to Subpart A of... - Minimum Capital Components for Interest Rate and Foreign Exchange Rate Contracts

Code of Federal Regulations, 2011 CFR

2011-01-01

... interest rate and foreign exchange rate contracts are computed on the basis of the credit equivalent amounts of such contracts. Credit equivalent amounts are computed for each of the following off-balance... Equivalent Amounts a. The minimum capital components for interest rate and foreign exchange rate contracts...

Small Business Innovations

NASA Technical Reports Server (NTRS)

1994-01-01

A Small Business Innovation Research (SBIR) contract resulted in a series of commercially available lasers, which have application in fiber optic communications, difference frequency generation, fiber optic sensing and general laboratory use. Developed under a Small Business Innovation Research (SBIR) contract, the Phase Doppler Particles Analyzer is a non-disruptive, highly accurate laser-based method of determining particle size, number density, trajectory, turbulence and other information about particles passing through a measurement probe volume. The system consists of an optical transmitter and receiver, signal processor and computer with data acquisition and analysis software. A variety of systems are offered for applications including spray characterization for paint, and agricultural and other sprays. The Microsizer, a related product, is used in medical equipment manufacturing and analysis of contained flows. High frequency components and subsystems produced by Millitech Corporation are marketed for both research and commercial use. These systems, which operate in the upper portion of the millimeter wave, resulted from a number of Small Business Innovation Research (SBIR) projects. By developing very high performance mixers and multipliers, the company has advanced the state of the art in sensitive receiver technology. Components are used in receivers and transceivers for monitoring chlorine monoxides, ozone, in plasma characterization and in material properties characterization.

A review and update of the Virginia Department of Transportation cash flow forecasting model.

DOT National Transportation Integrated Search

1996-01-01

This report details the research done to review and update components of the VDOT cash flow forecasting model. Specifically, the study updated the monthly factors submodel used to predict payments on construction contracts. For the other submodel rev...

Multi-KW dc distribution system technology research study

NASA Technical Reports Server (NTRS)

Dawson, S. G.

1978-01-01

The Multi-KW DC Distribution System Technology Research Study is the third phase of the NASA/MSFC study program. The purpose of this contract was to complete the design of the integrated technology test facility, provide test planning, support test operations and evaluate test results. The subjet of this study is a continuation of this contract. The purpose of this continuation is to study and analyze high voltage system safety, to determine optimum voltage levels versus power, to identify power distribution system components which require development for higher voltage systems and finally to determine what modifications must be made to the Power Distribution System Simulator (PDSS) to demonstrate 300 Vdc distribution capability.

Sustaining AMEDD Professional Strength in the Reserve Components

DTIC Science & Technology

2004-05-03

During the 8 May 2003 Reserve Component Coordination Council meeting8, General John Keane, then Vice Chief of Staff of the Army; Major General Kenneth...retirement. 2001 FOCUS GROUP DATA John Whaley and Dr. Sandra Baxter of Applied Research Analysts moderated six focus groups with the 313th and 399th...with the remainder to be made up from realignment of local structure, contracting medical professionals for the local hospital, or outsourcing to

The development and validation of a psychological contract of safety scale.

PubMed

Walker, Arlene

2010-08-01

This paper builds on previous research by the author and describes the development and validation of a new measure of the psychological contract of safety. The psychological contract of safety is defined as the beliefs of individuals about reciprocal safety obligations inferred from implicit and explicit promises. A psychological contract is established when an individual believes that perceived employer and employee safety obligations are contingent on each other. A pilot test of the measure is first undertaken with participants from three different occupations: nurses, construction workers, and meat processing workers (N=99). Item analysis is used to refine the measure and provide initial validation of the scale. A larger validation study is then conducted with a participant sample of health care workers (N=424) to further refine the measure and to determine the psychometric properties of the scale. Item and correlational analyses produced the final employer and employee obligations scales, consisting of 21 and 17 items, respectively. Factor analyses identified two underlying dimensions in each scale comparable to that previously established in the organizational literature. These transactional and relational-type obligations provided construct validity of the scale. Internal consistency ratings using Cronbach's alpha found the components of the psychological contract of safety measure to be reliable. The refined and validated psychological contract of safety measure will allow investigation of the positive and negative outcomes associated with fulfilment and breach of the psychological contract of safety in future research. 2010 Elsevier Ltd. All rights reserved.

78 FR 54796 - Research Expenditures

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-06

... the design of the product, or even redesign components of the product, after production of the product... is engaged in the manufacture and sale of custom machines. U contracts to design and produce a... design. See paragraph (a)(2) of this section (relating to production costs). Example 4. Assume the same...

A Multimedia Publishing Center from Scratch (and Scavenge).

ERIC Educational Resources Information Center

D'Ignazio, Fred

1995-01-01

Provides guidance for turning the library media center into a place where students can use multimedia tools for research, authoring, and publishing. Sidebars include: a multimedia club sample student contract, a component list for a multimedia workstation starter kit, a checklist for planning and assembling mini-centers, and a sample multimedia…

Modeling Psychological Contract Violation using Dual Regime Models: An Event-based Approach

PubMed Central

Hofmans, Joeri

2017-01-01

A good understanding of the dynamics of psychological contract violation requires theories, research methods and statistical models that explicitly recognize that violation feelings follow from an event that violates one's acceptance limits, after which interpretative processes are set into motion, determining the intensity of these violation feelings. Whereas theories—in the form of the dynamic model of the psychological contract—and research methods—in the form of daily diary research and experience sampling research—are available by now, the statistical tools to model such a two-stage process are still lacking. The aim of the present paper is to fill this gap in the literature by introducing two statistical models—the Zero-Inflated model and the Hurdle model—that closely mimic the theoretical process underlying the elicitation violation feelings via two model components: a binary distribution that models whether violation has occurred or not, and a count distribution that models how severe the negative impact is. Moreover, covariates can be included for both model components separately, which yields insight into their unique and shared antecedents. By doing this, the present paper offers a methodological-substantive synergy, showing how sophisticated methodology can be used to examine an important substantive issue. PMID:29163316

A review of typical thermal fatigue failure models for solder joints of electronic components

NASA Astrophysics Data System (ADS)

Li, Xiaoyan; Sun, Ruifeng; Wang, Yongdong

2017-09-01

For electronic components, cyclic plastic strain makes it easier to accumulate fatigue damage than elastic strain. When the solder joints undertake thermal expansion or cold contraction, different thermal strain of the electronic component and its corresponding substrate is caused by the different coefficient of thermal expansion of the electronic component and its corresponding substrate, leading to the phenomenon of stress concentration. So repeatedly, cracks began to sprout and gradually extend [1]. In this paper, the typical thermal fatigue failure models of solder joints of electronic components are classified and the methods of obtaining the parameters in the model are summarized based on domestic and foreign literature research.

78 FR 33392 - Public Availability of Consumer Product Safety Commission FY 2012 Service Contract Inventory

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-04

... made through a contract or task order; (B) The organizational component of the executive agency administering the contract, and the organizational component of the agency whose requirements are being met through contractor performance of the service; (C) The total dollar amount obligated for services under...

Comparison of two text message (mHealth) campaigns for the Deaf: Contracted out v. conducted in-house.

PubMed

Hacking, Damian; Lau, Yan Kwan; Haricharan, Hanne Jensen; Heap, Marion

2015-11-20

Cell phone-based health information (mobile health or mHealth) campaigns are an emerging technology. This evaluation focused on the aspect of cost of two health information campaigns, one on hypertension and one on pregnancy. Researchers could either contract out the technical components of the campaigns or attempt to run the campaigns themselves, in-house. The in-house campaigns cost an estimated ZAR13 548.72 v. the private provider quotes which ranged from ZAR27 542.97 to ZAR34 227.59. Running the campaigns in-house was more labour intensive and required more technical expertise, but had a reduced delivery failure rate (9.2% in-house v. 30.0% private provider). Running small to medium SMS (text message) campaigns for evaluative purposes proved advantageous over contracting out to private providers. Larger-scale evaluations and full-scale roll-out will require the services of private providers, but it is still essential that researchers actively engage with and monitor the technical aspects of these campaigns.

Sensor Systems Collect Critical Aerodynamics Data

NASA Technical Reports Server (NTRS)

2010-01-01

With the support of Small Business Innovation Research (SBIR) contracts with Dryden Flight Research Center, Tao of Systems Integration Inc. developed sensors and other components that will ultimately form a first-of-its-kind, closed-loop system for detecting, measuring, and controlling aerodynamic forces and moments in flight. The Hampton, Virginia-based company commercialized three of the four planned components, which provide sensing solutions for customers such as Boeing, General Electric, and BMW and are used for applications such as improving wind turbine operation and optimizing air flow from air conditioning systems. The completed system may one day enable flexible-wing aircraft with flight capabilities like those of birds.

U.S. Army Research Institute 1983 Annual Report

DTIC Science & Technology

1983-10-01

Olllc») v TYPE OF REPORT a PERIOD COVERED Annual; TY 1983 6 PERFORMING ORG. REPORT NUMBER 6. CONTRACT OR GRANT NUMBERf«) 10. PROGRAM ELEMENT...AtTWACT tCmSm mm nrmam «M» W nmommmr —ä Idomlllr br Mock mnkw; An overview of the FY83 research program la presented in terms of these five research...awards, in-house publication«, professional publications and pres- entations, FY83 program management (mission, the core program , the three component

Ballistic Testing and Product Quality Surveillance for the Interceptor Body Armor - Vest Components Need Improvement

DTIC Science & Technology

2011-01-03

six contracts. Interceptor Body Armor – Vest Components IBA is a modular body armor system that consists of an OTV, ceramic plates , and components...Armor - Vest Components Need Improvement Report Documentation Page Form ApprovedOMB No. 0704-0188 Public reporting burden for the...Ballistic Testing and Product Quality Surveillance for the Interceptor Body Armor - Vest Components Need Improvement 5a. CONTRACT NUMBER 5b. GRANT

Spatiotemporal mapping of the muscular activity of the gizzard of the chicken (Gallus domesticus).

PubMed

Lentle, R G; Reynolds, G; de Loubens, C; Hulls, C; Janssen, P W M; Ravindran, V

2013-02-01

We report the results of spatiotemporal mapping of the spontaneous actions of component muscles of the gizzard and associated structures in ex vivo preparations with combined superfusion and vascular perfusion. Ongoing spontaneous contraction of cranial and caudal thin muscles occurred at a frequency of 2.2 ± 0.1 cycles per minute. Contractions of M. tenuis craniodorsalis with mean duration of 2.8 ± 0.2 s commenced ventrally adjacent to the distal limit of the proventriculus and progressed dorsally at 2.02 ± 0.03 mm•s(-1) in a concerted front. Near simultaneous contraction of M. tenuis caudoventralis of mean duration of contraction of 4.7 ± 0.7 s commenced dorsally and progressed ventrally at a similar rate (2.1 ± 0.1 mm•s(-1)) and in a similar manner. Contraction of the caudoventralis preceded that of craniodorsalis (mean 1.1 ± 0.15 s). Contraction of the 2 tenuis muscles was synchronous with the first component peak of the cyclic increase in lumen pressure and with distension of the crassus musculature. Contraction of the M. crassus caudodorsalis muscle coincided with the second component peak and was followed by distension of the tenuis musculature. The latter commenced before the relaxation of the tenuis muscles. Contractions of the crassus muscle propagated rapidly at right angles to the orientation of the muscle fibers at a faster velocity than that of the tenuis musculature. The durations of the component peaks in lumen pressure indicated that the duration of crassus contraction was similar to that of the tenuis musculature.

75 FR 32638 - Defense Federal Acquisition Regulation Supplement; Contract Authority for Advanced Component...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... Prototype Units (DFARS Case 2009-D034) AGENCY: Defense Acquisition Regulations System, Department of Defense... Component Development or Prototype Units.'' Section 819 is intended to prevent a contract for new technology... development of advanced components or the procurement of prototype units. To do so, section 819 places...

High speed packet switching

NASA Technical Reports Server (NTRS)

1991-01-01

This document constitutes the final report prepared by Proteon, Inc. of Westborough, Massachusetts under contract NAS 5-30629 entitled High-Speed Packet Switching (SBIR 87-1, Phase 2) prepared for NASA-Greenbelt, Maryland. The primary goal of this research project is to use the results of the SBIR Phase 1 effort to develop a sound, expandable hardware and software router architecture capable of forwarding 25,000 packets per second through the router and passing 300 megabits per second on the router's internal busses. The work being delivered under this contract received its funding from three different sources: the SNIPE/RIG contract (Contract Number F30602-89-C-0014, CDRL Sequence Number A002), the SBIR contract, and Proteon. The SNIPE/RIG and SBIR contracts had many overlapping requirements, which allowed the research done under SNIPE/RIG to be applied to SBIR. Proteon funded all of the work to develop new router interfaces other than FDDI, in addition to funding the productization of the router itself. The router being delivered under SBIR will be a fully product-quality machine. The work done during this contract produced many significant findings and results, summarized here and explained in detail in later sections of this report. The SNIPE/RIG contract was completed. That contract had many overlapping requirements with the SBIR contract, and resulted in the successful demonstration and delivery of a high speed router. The development that took place during the SNIPE/RIG contract produced findings that included the choice of processor and an understanding of the issues surrounding inter processor communications in a multiprocessor environment. Many significant speed enhancements to the router software were made during that time. Under the SBIR contract (and with help from Proteon-funded work), it was found that a single processor router achieved a throughput significantly higher than originally anticipated. For this reason, a single processor router was developed and the final delivery under this contract will include a single processor CNX-500 router. The router and its interface boards (2 FDDIs and 2 dual-ethernets) are all product-quality components.

Small gas turbine engine technology

NASA Technical Reports Server (NTRS)

Niedzwiecki, Richard W.; Meitner, Peter L.

1988-01-01

Performance of small gas turbine engines in the 250 to 1,000 horsepower size range is significantly lower than that of large engines. Engines of this size are typically used in rotorcraft, commutercraft, general aviation, and cruise missile applications. Principal reasons for the lower efficiencies of a smaller engine are well known: component efficients are lower by as much as 8 to 10 percentage points because of size effects. Small engines are designed for lower cycle pressures and temperatures because of smaller blading and cooling limitations. The highly developed analytical and manufacturing techniques evolved for large engines are not directly transferrable to small engines. Thus, it was recognized that a focused effort addressing technologies for small engies was needed and could significantly impact their performance. Recently, in-house and contract studies were undertaken at the NASA Lewis Research Center to identify advanced engine cycle and component requirements for substantial performance improvement of small gas turbines for projected year 2000 applications. The results of both in-house research and contract studies are presented. In summary, projected fuel savings of 22 to 42 percent could be obtained. Accompanying direct operating cost reductions of 11 to 17 percent, depending on fuel cost, were also estimated. High payoff technologies are identified for all engine applications, and recent results of experimental research to evolve the high payoff technologies are described.

Effects of axisymmetric contractions on turbulence of various scales

NASA Technical Reports Server (NTRS)

Tan-Atichat, J.; Nagib, H. M.; Drubka, R. E.

1980-01-01

Digitally acquired and processed results from an experimental investigation of grid generated turbulence of various scales through and downstream of nine matched cubic contour contractions ranging in area ratio from 2 to 36, and in length to inlet diameter ratio from 0.25 to 1.50 are reported. An additional contraction with a fifth order contour was also utilized for studying the shape effect. Thirteen homogeneous and nearly isotropic test flow conditions with a range of turbulence intensities, length scales and Reynolds numbers were generated and used to examine the sensitivity of the contractions to upstream turbulence. The extent to which the turbulence is altered by the contraction depends on the incoming turbulence scales, the total strain experienced by the fluid, as well as the contraction ratio and the strain rate. Varying the turbulence integral scale influences the transverse turbulence components more than the streamwise component. In general, the larger the turbulence scale, the lesser the reduction in the turbulence intensity of the transverse components. Best agreement with rapid distortion theory was obtained for large scale turbulence, where viscous decay over the contraction length was negligible, or when a first order correction for viscous decay was applied to the results.

Electromechanical delay components during skeletal muscle contraction and relaxation in patients with myotonic dystrophy type 1.

PubMed

Esposito, Fabio; Cè, Emiliano; Rampichini, Susanna; Limonta, Eloisa; Venturelli, Massimo; Monti, Elena; Bet, Luciano; Fossati, Barbara; Meola, Giovanni

2016-01-01

The electromechanical delay during muscle contraction and relaxation can be partitioned into mainly electrochemical and mainly mechanical components by an EMG, mechanomyographic, and force combined approach. Component duration and measurement reliability were investigated during contraction and relaxation in a group of patients with myotonic dystrophy type 1 (DM1, n = 13) and in healthy controls (n = 13). EMG, mechanomyogram, and force were recorded in DM1 and in age- and body-matched controls from tibialis anterior (distal muscle) and vastus lateralis (proximal muscle) muscles during maximum voluntary and electrically-evoked isometric contractions. The electrochemical and mechanical components of the electromechanical delay during muscle contraction and relaxation were calculated off-line. Maximum strength was significantly lower in DM1 than in controls under both experimental conditions. All electrochemical and mechanical components were significantly longer in DM1 in both muscles. Measurement reliability was very high in both DM1 and controls. The high reliability of the measurements and the differences between DM1 patients and controls suggest that the EMG, mechanomyographic, and force combined approach could be utilized as a valid tool to assess the level of neuromuscular dysfunction in this pathology, and to follow the efficacy of pharmacological or non-pharmacological interventions. Copyright © 2015 Elsevier B.V. All rights reserved.

Automated reuseable components system study results

NASA Technical Reports Server (NTRS)

Gilroy, Kathy

1989-01-01

The Automated Reusable Components System (ARCS) was developed under a Phase 1 Small Business Innovative Research (SBIR) contract for the U.S. Army CECOM. The objectives of the ARCS program were: (1) to investigate issues associated with automated reuse of software components, identify alternative approaches, and select promising technologies, and (2) to develop tools that support component classification and retrieval. The approach followed was to research emerging techniques and experimental applications associated with reusable software libraries, to investigate the more mature information retrieval technologies for applicability, and to investigate the applicability of specialized technologies to improve the effectiveness of a reusable component library. Various classification schemes and retrieval techniques were identified and evaluated for potential application in an automated library system for reusable components. Strategies for library organization and management, component submittal and storage, and component search and retrieval were developed. A prototype ARCS was built to demonstrate the feasibility of automating the reuse process. The prototype was created using a subset of the classification and retrieval techniques that were investigated. The demonstration system was exercised and evaluated using reusable Ada components selected from the public domain. A requirements specification for a production-quality ARCS was also developed.

Structured Transition of Wind Tunnel Operations Skills from Government-to Contractor-Managed

NASA Technical Reports Server (NTRS)

Dunn, Steven C.; Schlank, John J.

2010-01-01

In 2004, NASA awarded the Research, Operations, Maintenance, and Engineering (ROME) contract at NASA Langley Research Center to a team led by Jacobs Technology, Inc. A key component of the contract was the transitioning of the five large wind tunnel facilities from NASA managed and NASA or NASA/contractor workforces to fully contractor operated. The contractor would manage daily operations while NASA would continue to develop long-term strategies, make decisions regarding commitment of funds and commitment of facilities, and provide oversight of the contractor's performance. A major challenge would be the transition of knowledge of facility operations and maintenance from the incumbent civil servant workforce to the contractor workforce. While the contract has since been modified multiple times, resulting in a blended NASA/ROME workforce across the facilities, the processes developed and implemented to capture and document facility knowledge from the incumbent subject matter experts, build training and certification programs, and grow individual skills across subject areas and across facilities, are worthy of documentation. This is the purpose of this paper.

Evaluation of Ammunition Data Cards (REDACTED)

DTIC Science & Technology

2016-04-29

Procuring Contracting Officer ( PCO ), the manufacturer shall include, in the components sections on ADC representing the munition, all assemblies...lot components or evidence of PCO waiver approval. As a result, ADCs did not consistently include component items that make up the ammunition, and...Energetics PCO Procuring Contract Officer PQM Product Quality Manager QALI Quality Assurance Letter of Instruction QAR Quality Assurance Representative

48 CFR 1235.7000 - Contract clause.

Code of Federal Regulations, 2012 CFR

2012-10-01

... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause. The contracting officer shall insert the clause at (TAR) 48 CFR 1252.235-70, Research Misconduct, in... Policy on Research Misconduct,” dated February 2002. ...

48 CFR 1235.7000 - Contract clause.

Code of Federal Regulations, 2013 CFR

2013-10-01

... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause. The contracting officer shall insert the clause at (TAR) 48 CFR 1252.235-70, Research Misconduct, in... Policy on Research Misconduct,” dated February 2002. ...

48 CFR 1235.7000 - Contract clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause. The contracting officer shall insert the clause at (TAR) 48 CFR 1252.235-70, Research Misconduct, in... Policy on Research Misconduct,” dated February 2002. ...

48 CFR 1235.7000 - Contract clause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause. The contracting officer shall insert the clause at (TAR) 48 CFR 1252.235-70, Research Misconduct, in... Policy on Research Misconduct,” dated February 2002. ...

Exchange relationships: examining psychological contracts and perceived organizational support.

PubMed

Coyle-Shapiro, Jacqueline A-M; Conway, Neil

2005-07-01

The authors surveyed 347 public sector employees on 4 measurement occasions to investigate the conceptual distinctiveness of the psychological contract and perceived organizational support (POS) and how they are associated over time. Results support the distinctiveness of the 2 concepts. In terms of their interrelationships over time, by drawing on psychological contract theory the authors found little support for a reciprocal relationship between POS and psychological contract fulfillment. Under an alternative set of hypotheses, by drawing on organizational support theory and by separating psychological contract fulfillment into its 2 components (perceived employer obligations and inducements), the authors found that perceived employer inducements were positively related to POS, which, in turn, was negatively related to perceived employer obligations. The results suggest that POS and the components of psychological contract fulfillment are more important in predicting organizational citizenship behavior than psychological contract fulfillment. Copyright 2005 APA, all rights reserved.

Training Lessons Learned from Peak Performance Episodes

DTIC Science & Technology

1986-06-01

PEAK PERFORMAN4CE Fina Report- EPSOESOctober 1984-December 1985 % 6. PERFORMING ORG. REPORT NUMBER * 7. AUTHOR(@) 6. CONTRACT OR GRANT NUMBER(s) James...L. Fobes - 9. PERFORMING ORGANIZATION NAME AND) ADDRESS 10. PROGRAM ELEMENT. PROJECT, TASK U.S. Army Research Institute Field UnitAEA OKUINMER...peak performance indicates that three cogni- . tive components enable these episodes: psychological readiness (activating . optimal arousal and emotion

Functional Epitaxial Oxide Devices

DTIC Science & Technology

2010-04-12

complex oxides , epitaxial growth, antennas, varactors 16. SECURITY CLASSIFICATION OF: REPORT U b. ABSTRACT u c. THIS PAGE u 17. LIMITATION OF...Technical Report DATES COVERED (From - To) 17-06-2008-31-12-2009 4. TITLE AND SUBTITLE Functional Epitaxial Oxide Devices 5a. CONTRACT NUMBER NA...This research effort addresses the need for high performance radio frequency (RF) components, specifically varactors and miniaturized, high gain

NWHSS Implement Family Member Assessment Component in the Millennium Cohort Study

DTIC Science & Technology

2014-12-01

Surveys: The Tailored Design Method, 3rd edition , Hoboken, NJ, John Wiley & Sons. Dillman D.A., Smyth J.D., Christian L.M., O’Neill A. (2008) Will a...TYPE Final Report 3 . DATES COVERED (From - To) 28 Sep 2009 – 27 Sep 2014 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER NWHSS...23 3 . Key Research Accomplishments

48 CFR 46.308 - Cost-reimbursement research and development contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... research and development contracts. 46.308 Section 46.308 Federal Acquisition Regulations System FEDERAL... research and development contracts. The contracting officer shall insert the clause at 52.246-8, Inspection of Research and Development—Cost-Reimbursement, in solicitations and contracts for research and...

48 CFR 46.308 - Cost-reimbursement research and development contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... research and development contracts. 46.308 Section 46.308 Federal Acquisition Regulations System FEDERAL... research and development contracts. The contracting officer shall insert the clause at 52.246-8, Inspection of Research and Development—Cost-Reimbursement, in solicitations and contracts for research and...

12 CFR Appendix A to Subpart A of... - Minimum Capital Components for Interest Rate and Foreign Exchange Rate Contracts

Code of Federal Regulations, 2010 CFR

2010-01-01

... sheet interest rate and foreign exchange rate contracts: a. Interest Rate Contracts i. Single currency... Contracts i. Cross-currency interest rate swaps. ii. Forward foreign exchange rate contracts. iii. Currency... exposure is zero. Mark-to-market values are measured in United States dollars, regardless of the currency...

Army Contract Writing System (ACWS)

DTIC Science & Technology

2016-03-01

2016 Major Automated Information System Annual Report Army Contract Writing System (ACWS) Defense Acquisition Management Information Retrieval...Program Information Program Name Army Contract Writing System (ACWS) DoD Component Army Responsible Office Program Manager References MAIS...UNCLASSIFIED 4 Program Description The Army Contract Writing System (ACWS) will be the Army’s single, next-generation, enterprise-wide contract writing

26 CFR 1.460-1 - Long-term contracts.

Code of Federal Regulations, 2010 CFR

2010-04-01

... the manufacture of personal property is a manufacturing contract. In contrast, a contract for the... performance of engineering and design services, and the production of components and subassemblies that are..., enters into a single long-term contract to design and manufacture a satellite and to develop computer...

48 CFR 235.070-1 - Indemnification under research and development contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... research and development contracts. 235.070-1 Section 235.070-1 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.070-1 Indemnification under research and development contracts. (a...

Reconfigurable Hardware Adapts to Changing Mission Demands

NASA Technical Reports Server (NTRS)

2003-01-01

A new class of computing architectures and processing systems, which use reconfigurable hardware, is creating a revolutionary approach to implementing future spacecraft systems. With the increasing complexity of electronic components, engineers must design next-generation spacecraft systems with new technologies in both hardware and software. Derivation Systems, Inc., of Carlsbad, California, has been working through NASA s Small Business Innovation Research (SBIR) program to develop key technologies in reconfigurable computing and Intellectual Property (IP) soft cores. Founded in 1993, Derivation Systems has received several SBIR contracts from NASA s Langley Research Center and the U.S. Department of Defense Air Force Research Laboratories in support of its mission to develop hardware and software for high-assurance systems. Through these contracts, Derivation Systems began developing leading-edge technology in formal verification, embedded Java, and reconfigurable computing for its PF3100, Derivational Reasoning System (DRS ), FormalCORE IP, FormalCORE PCI/32, FormalCORE DES, and LavaCORE Configurable Java Processor, which are designed for greater flexibility and security on all space missions.

48 CFR 335.071 - Special determinations and findings affecting research and development contracting.

Code of Federal Regulations, 2010 CFR

2010-10-01

... findings affecting research and development contracting. 335.071 Section 335.071 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 335.071 Special determinations and findings affecting research and development contracting. OPDIV...

Contracts, grants and funding summary of supersonic cruise research and variable-cycle engine technology programs, 1972 - 1982

NASA Technical Reports Server (NTRS)

Hoffman, S.; Varholic, M. C.

1983-01-01

NASA-SCAR (AST) program was initiated in 1972 at the direct request of the Executive Office of the White House and Congress following termination of the U.S. SST program. The purpose of SCR was to conduct a focused research and technology program on those technology programs which contributed to the SST termination and, also, to provide an expanded data base for future civil and military supersonic transport aircraft. Funding for the Supersonic Cruise Research (SCR) Program was initiated in fiscal year 1973 and terminated in fiscal year 1981. The program was implemented through contracts and grants with industry, universities, and by in-house investigations at the NASA/OAST centers. The studies included system studies and five disciplines: propulsion, stratospheric emissions impact, materials and structures, aerodynamic performance, and stability and control. The NASA/Lewis Variable-Cycle Engine (VCE) Component Program was initiated in 1976 to augment the SCR program in the area of propulsion. After about 2 years, the title was changed to VCE Technology program. The total number of contractors and grantees on record at the AST office in 1982 was 101 for SCR and 4 for VCE. This paper presents a compilation of all the contracts and grants as well as the funding summaries for both programs.

Flow Induced Vibration Program at Argonne National Laboratory

NASA Astrophysics Data System (ADS)

1984-01-01

The Argonne National Laboratory's Flow Induced Vibration Program, currently residing in the Laboratory's Components Technology Division is discussed. Throughout its existence, the overall objective of the program was to develop and apply new and/or improved methods of analysis and testing for the design evaluation of nuclear reactor plant components and heat exchange equipment from the standpoint of flow induced vibration. Historically, the majority of the program activities were funded by the US Atomic Energy Commission, the Energy Research and Development Administration, and the Department of Energy. Current DOE funding is from the Breeder Mechanical Component Development Division, Office of Breeder Technology Projects; Energy Conversion and Utilization Technology Program, Office of Energy Systems Research; and Division of Engineering, Mathematical and Geosciences, office of Basic Energy Sciences. Testing of Clinch River Breeder Reactor upper plenum components was funded by the Clinch River Breeder Reactor Plant Project Office. Work was also performed under contract with Foster Wheeler, General Electric, Duke Power Company, US Nuclear Regulatory Commission, and Westinghouse.

77 FR 2757 - Certain Electric Fireplaces, Components Thereof, Manuals for Same, Certain Processes for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-19

..., misappropriation of trade secrets, breach of contract, and tortious interference with contract. The complaint... by reason of misappropriation of trade secrets, breach of contract, or tortious interference with...

48 CFR 245.7310-1 - Demilitarization.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... Demilitarization will be accomplished as specified in the contract. Component parts vital to the military or lethal... as specified in the contract. Component parts vital to the military or lethal purpose of the property... shall deduct these costs from the purchase price and refund the balance of the purchase price, if any...

28 CFR 513.36 - Government contractors.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Government contractors. 513.36 Section... contractors. (a) No Bureau component may contract for the operation of a record system by or on behalf of the... component shall have the responsibility to ensure that the contractor complies with the contract...

Aeronautical engineering: A special bibliography with indexes, supplement 49

NASA Technical Reports Server (NTRS)

1974-01-01

The bibliography contains 368 abstract citations of reports, journal articles, and other documents concerned with the engineering and theoretical aspects of design, construction, evaluation, testing, operation, and performance of aircraft (including aircraft engines) and associated components, equipment, and systems. Research and development in aerodynamics, aeronautics, and ground support equipment are also treated. Subject, personal, and contract number indexes are included for ease of access.

Funding for Life: When to Spend the Acquisition Pot

DTIC Science & Technology

2010-05-01

Private Military Sector Software Requirements for OA Spiral Development Strategy for Defense Acquisition Research The Software, Hardware...qb=p`elli= Capital Budgeting for the DoD Energy Saving Contracts/DoD Mobile Assets Financing DoD Budget via PPPs Lessons from Private Sector ...the endeavor can, in part, be related to the stability of the aims and contributory components. Economic growth has been driven by globalisation

Design of a high-performance rotary stratified-charge research aircraft engine

NASA Technical Reports Server (NTRS)

Jones, C.; Mount, R. E.

1984-01-01

The power section for an advanced rotary stratified-charge general aviation engine has been designed under contract to NASA. The single-rotor research engine of 40 cubic-inches displacement (RCI-40), now being procured for test initiation this summer, is targeted for 320 T.O. horse-power in a two-rotor production engine. The research engine is designed for operating on jet-fuel, gasoline or diesel fuel and will be used to explore applicable advanced technologies and to optimize high output performance variables. Design of major components of the engine is described in this paper.

Free-piston Stirling component test power converter test results and potential Stirling applications

NASA Technical Reports Server (NTRS)

Dochat, G. R.

1992-01-01

As the principal contractor to NASA-Lewis Research Center, Mechanical Technology Incorporated is under contract to develop free-piston Stirling power converters in the context of the competitive multiyear Space Stirling Technology Program. The first generation Stirling power converter, the component test power converter (CTPC) initiated cold end testing in 1991, with hot testing scheduled for summer of 1992. This paper reviews the test progress of the CTPC and discusses the potential of Stirling technology for various potential missions at given point designs of 250 watts, 2500 watts, and 25,000 watts.

48 CFR 1235.7000 - Contract clause.

Code of Federal Regulations, 2014 CFR

2014-10-01

... all solicitations and contracts for research and development. For further information, see DOT's Implementation Guidance for Executive Office of the President, Office of Science and Technology Policy, “Federal... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Research Misconduct 1235.7000 Contract clause...

Crop area estimation based on remotely-sensed data with an accurate but costly subsample

NASA Technical Reports Server (NTRS)

Gunst, R. F.

1985-01-01

Research activities conducted under the auspices of National Aeronautics and Space Administration Cooperative Agreement NCC 9-9 are discussed. During this contract period research efforts are concentrated in two primary areas. The first are is an investigation of the use of measurement error models as alternatives to least squares regression estimators of crop production or timber biomass. The secondary primary area of investigation is on the estimation of the mixing proportion of two-component mixture models. This report lists publications, technical reports, submitted manuscripts, and oral presentation generated by these research efforts. Possible areas of future research are mentioned.

Optical induction of muscle contraction at the tissue scale through intrinsic cellular amplifiers.

PubMed

Yoon, Jonghee; Choi, Myunghwan; Ku, Taeyun; Choi, Won Jong; Choi, Chulhee

2014-08-01

The smooth muscle cell is the principal component responsible for involuntary control of visceral organs, including vascular tonicity, secretion, and sphincter regulation. It is known that the neurotransmitters released from nerve endings increase the intracellular Ca(2+) level in smooth muscle cells followed by muscle contraction. We herein report that femtosecond laser pulses focused on the diffraction-limited volume can induce intracellular Ca(2+) increases in the irradiated smooth muscle cell without neurotransmitters, and locally increased intracellular Ca(2+) levels are amplified by calcium-induced calcium-releasing mechanisms through the ryanodine receptor, a Ca(2+) channel of the endoplasmic reticulum. The laser-induced Ca(2+) increases propagate to adjacent cells through gap junctions. Thus, ultrashort-pulsed lasers can induce smooth muscle contraction by controlling Ca(2+), even with optical stimulation of the diffraction-limited volume. This optical method, which leads to reversible and reproducible muscle contraction, can be used in research into muscle dynamics, neuromuscular disease treatment, and nanorobot control. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

48 CFR 35.015 - Contracts for research with educational institutions and nonprofit organizations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Contracts for research with educational institutions and nonprofit organizations. 35.015 Section 35.015 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.015 Contracts for research...

48 CFR 35.015 - Contracts for research with educational institutions and nonprofit organizations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Contracts for research with educational institutions and nonprofit organizations. 35.015 Section 35.015 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.015 Contracts for research...

48 CFR 35.015 - Contracts for research with educational institutions and nonprofit organizations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Contracts for research with educational institutions and nonprofit organizations. 35.015 Section 35.015 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.015 Contracts for research...

Anisotropy of human muscle via non invasive impedance measurements. Frequency dependence of the impedance changes during isometric contractions

NASA Astrophysics Data System (ADS)

Kashuri, Hektor

In this thesis we present non invasive muscle impedance measurements using rotatable probes extending the work done by Aaron et al. (1997) by measuring not only the real part of the impedance but the imaginary part as well. The results reveal orientations of underlying muscle fibers via minima in resistance and reactance versus angle curves, suggesting this method as potentially useful for studying muscle properties in clinical and physiological research. Calculations of the current distribution for a slab of material with anisotropic conductivity show that the current distribution depends strongly on the separation of two current electrodes and as well as on its conducting anisotropy. Forearm muscle impedance measurements at 50 kHz done by Shiffman et al. (2003) had shown that both resistance (R) and reactance (X) increase during isometric contraction. We have extended these measurements in the 3 to 100 kHz range and we found that resistance (R) and reactance (X) both increase and their changes increased or decreased at frequency dependent rates. Analysis based on circuit models of changes in R and X during the short contraction pulses showed that the extra cellular fluid resistance increased by 3.9 +/- 1.4 %, while the capacitance increased by 5.6 +/- 2 %. For long contraction pulses at very low frequencies: (1) there was practically no change in R during contraction, which implies that these changes are due to cellular membrane or intracellular effects with the extra cellular water component not participating, and (2) in post contraction stage there were no morphological changes which means that drifts in R can only be due to physiological changes. Following Shiffman et al. (2003) we measured impedance changes of R and X during a triangular shaped pulse of force generated via isometric forearm muscle contraction at 50 kHz. We measured these changes in 3-100 kHz frequency range for a stair case pulse of forces and the results showed that they are frequency dependent. Analysis based on circuit models suggest that the increase of isometric forearm muscle contraction is accompanied with both extra and intra cellular effects. The decrease following it is accompanied with changes in the extra cellular components and with intracellular elements remaining at the values they have at the maximum contraction force.

Deregulation Impact in Negotiating a New Electrical Contract Between NASA Glenn Research Center at Lewis Field and FirstEnergy Corp., Cleveland, Ohio, USA

NASA Technical Reports Server (NTRS)

Quach, Quyen T.; Zala, Laszlo F.

2002-01-01

The governor of the State of Ohio signed amended substitute Senate bill 3 on July 6, 1999, requiring Ohio's electric industry to change from a monopoly environment to a competitive electric environment for generation services. The start date for competitive retail generation services was set for January 1, 2001. This new deregulation law allowed all Ohioans to choose the supplier of generation service, but the transmission and distribution would remain regulated. It also required electric utilities to unbundle the three main components (generation, transmission, and distribution) and make other changes designed to produce a competitive electric generation market. While deregulation was taking shape, the NASA Glenn Research Center electrical contract with FirstEnergy Corp. of Cleveland, Ohio, was to expire on September 7, 1999. Glenn strategically evaluated and incorporated the impacts of electric deregulation in the negotiations. Glenn and FirstEnergy spent over a year in negotiations until the Glenn utility team and the FirstEnergy negotiating team came to an agreement in the fall of 2000, and a new contract became effective on January 1, 2001.

48 CFR 46.309 - Research and development contracts (short form).

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Research and development contracts (short form). 46.309 Section 46.309 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.309 Research and development contracts...

Orbit Transfer Rocket Engine Technology Program. Task C.5. Enhanced Heat Transfer Combustor Technology

DTIC Science & Technology

1991-12-01

December, 1991 i--" NASA-Lewis Research Center Cleveland, Ohio 44135 94-08573 Contract No. NAS3-23773 .0l•!ill~• 111 l94 3 16 09V PISULATIXI NOTICI... 3 3.1 Test Hardware and Facility Description...V - Drawings and Layouts of Calorimeter Insert and Related Hardware .... 133 - Ui - FIGURES NUMBER PIALE GE 3 -1 Integrated Component Evaluator (I.C.E

Advanced flight hardware for organic separations using aqueous two-phase partitioning

NASA Astrophysics Data System (ADS)

Deuser, Mark S.; Vellinger, John C.; Weber, John T.

1996-03-01

Separation of cells and cell components is the limiting factor in many biomedical research and pharmaceutical development processes. Aqueous Two-Phase Partitioning (ATPP) is a unique separation technique which allows purification and classification of biological materials. SHOT has employed the ATPP process in separation equipment developed for both space and ground applications. Initial equipment development and research focused on the ORganic SEParation (ORSEP) space flight experiments that were performed on suborbital rockets and the shuttle. ADvanced SEParations (ADSEP) technology was developed as the next generation of ORSEP equipment through a NASA Small Business Innovation Research (SBIR) contract. Under the SBIR contract, a marketing study was conducted, indicating a growing commercial market exists among biotechnology firms for ADSEP equipment and associated flight research and development services. SHOT is preparing to begin manufacturing and marketing laboratory versions of the ADSEP hardware for the ground-based market. In addition, through a self-financed SBIR Phase III effort, SHOT is fabricating and integrating the ADSEP flight hardware for a commercially-driven SPACEHAB 04 experiment that will be the initial step in marketing space separations services. The ADSEP ground-based and microgravity research is expected to play a vital role in developing important new biomedical and pharmaceutical products.

48 CFR 1335.006 - Contracting methods and contract type.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.006 Contracting methods and... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contracting methods and... research services under the contract might involve the use of human subjects. The provision is mandatory...

Aspects of research and development contract terms in the bio/pharmaceutical sector.

PubMed

Banerjee, Tannista

2012-01-01

The cost of new drug development is increasing every year. Pharmaceutical companies use R&D joint ventures, mergers, and outsource different stages of pharmaceutical R&D activities for a faster and cost minimizing method of innovation. Pharmaceutical companies outsource R&D activities to independent small biotech or pharmaceutical companies that specialize in different stages of pharmaceutical R&D. This chapter examines the determinants of the payment structure of research contracts between large bio/pharmaceutical companies and specialized research firms. Determinants of R&D contracts are analyzed using detailed R&D contract data between bio/pharmaceutical companies and independent research firms for 10 years. A multinomial logit model is used in order to understand the determinants of three different types of contracts; royalty contracts, fixed payment contracts, and the mixed contracts. Under uncertainty, the likelihood of a royalty contract rises for the early stages of the research and with the patent stock of the research firm. It is more likely to observe both royalty and fixed payment if the pharmaceutical client has past contracts with the same research firm. The results also suggest that if Food and Drug Administration (FDA) is more stringent in any disease area in reviewing the new drug application, then the likelihood of signing pure royalty contract decreases. Understanding the nature of R&D contracts and the effects of FDA's behavior on the pharmaceutical R&D contract is important because these contracts not only affect the cost of new drug invention but also the quality and the rate of invention. VALUE: Results are useful for both the pharmaceutical companies and the economic/business researchers.

Process Improvement for Interinstitutional Research Contracting

PubMed Central

Logan, Jennifer; Bjorklund, Todd; Whitfield, Jesse; Reed, Peggy; Lesher, Laurie; Sikalis, Amy; Brown, Brent; Drollinger, Sandy; Larrabee, Kristine; Thompson, Kristie; Clark, Erin; Workman, Michael; Boi, Luca

2015-01-01

Abstract Introduction Sponsored research increasingly requires multiinstitutional collaboration. However, research contracting procedures have become more complicated and time consuming. The perinatal research units of two colocated healthcare systems sought to improve their research contracting processes. Methods The Lean Process, a management practice that iteratively involves team members in root cause analyses and process improvement, was applied to the research contracting process, initially using Process Mapping and then developing Problem Solving Reports. Results Root cause analyses revealed that the longest delays were the individual contract legal negotiations. In addition, the “business entity” was the research support personnel of both healthcare systems whose “customers” were investigators attempting to conduct interinstitutional research. Development of mutually acceptable research contract templates and language, chain of custody templates, and process development and refinement formats decreased the Notice of Grant Award to Purchase Order time from a mean of 103.5 days in the year prior to Lean Process implementation to 45.8 days in the year after implementation (p = 0.004). Conclusions The Lean Process can be applied to interinstitutional research contracting with significant improvement in contract implementation. PMID:26083433

Process Improvement for Interinstitutional Research Contracting.

PubMed

Varner, Michael; Logan, Jennifer; Bjorklund, Todd; Whitfield, Jesse; Reed, Peggy; Lesher, Laurie; Sikalis, Amy; Brown, Brent; Drollinger, Sandy; Larrabee, Kristine; Thompson, Kristie; Clark, Erin; Workman, Michael; Boi, Luca

2015-08-01

Sponsored research increasingly requires multiinstitutional collaboration. However, research contracting procedures have become more complicated and time consuming. The perinatal research units of two colocated healthcare systems sought to improve their research contracting processes. The Lean Process, a management practice that iteratively involves team members in root cause analyses and process improvement, was applied to the research contracting process, initially using Process Mapping and then developing Problem Solving Reports. Root cause analyses revealed that the longest delays were the individual contract legal negotiations. In addition, the "business entity" was the research support personnel of both healthcare systems whose "customers" were investigators attempting to conduct interinstitutional research. Development of mutually acceptable research contract templates and language, chain of custody templates, and process development and refinement formats decreased the Notice of Grant Award to Purchase Order time from a mean of 103.5 days in the year prior to Lean Process implementation to 45.8 days in the year after implementation (p = 0.004). The Lean Process can be applied to interinstitutional research contracting with significant improvement in contract implementation. © 2015 Wiley Periodicals, Inc.

In vitro models of tail contraction and cytoplasmic streaming in amoeboid cells.

PubMed

Janson, L W; Taylor, D L

1993-10-01

We have developed a reconstituted gel-sol and contractile model system that mimics the structure and dynamics found at the ectoplasm/endoplasm interface in the tails of many amoeboid cells. We tested the role of gel-sol transformations of the actin-based cytoskeleton in the regulation of contraction and in the generation of endoplasm from ectoplasm. In a model system with fully phosphorylated myosin II, we demonstrated that either decreasing the actin filament length distribution or decreasing the extent of actin filament cross-linking initiated both a weakening of the gel strength and contraction. However, streaming of the solated gel components occurred only under conditions where the length distribution of actin was decreased, causing a self-destruct process of continued solation and contraction of the gel. These results offer significant support that gel strength plays an important role in the regulation of actin/myosin II-based contractions of the tail cortex in many amoeboid cells as defined by the solation-contraction coupling hypothesis (Taylor, D. L., and M. Fechheimer. 1982. Phil. Trans. Soc. Lond. B. 299:185-197). The competing processes of solation and contraction of the gel would appear to be mutually exclusive. However, it is the temporal-spatial balance of the rate and extent of two stages of solation, coupled to contraction, that can explain the conversion of gelled ectoplasm in the tail to a solated endoplasm within the same small volume, generation of a force for the retraction of tails, maintenance of cell polarity, and creation of a positive hydrostatic pressure to push against the newly formed endoplasm. The mechanism of solation-contraction of cortical cytoplasm may be a general component of the normal movement of a variety of amoeboid cells and may also be a component of other contractile events such as cytokinesis.

48 CFR 2035.70 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 2035.70 Contract clauses. (a) The contracting officer shall insert the following clause in all solicitations and contracts for research and development by private contractors and universities and for other technical services, as appropriate: (1) Section 2052.235-70...

Actin turnover maintains actin filament homeostasis during cytokinetic ring contraction

PubMed Central

Palani, Saravanan; Sommese, Ruth; Kamnev, Anton; Hatano, Tomoyuki; Sivaramakrishnan, Sivaraj

2017-01-01

Cytokinesis in many eukaryotes involves a tension-generating actomyosin-based contractile ring. Many components of actomyosin rings turn over during contraction, although the significance of this turnover has remained enigmatic. Here, using Schizosaccharomyces japonicus, we investigate the role of turnover of actin and myosin II in its contraction. Actomyosin ring components self-organize into ∼1-µm-spaced clusters instead of undergoing full-ring contraction in the absence of continuous actin polymerization. This effect is reversed when actin filaments are stabilized. We tested the idea that the function of turnover is to ensure actin filament homeostasis in a synthetic system, in which we abolished turnover by fixing rings in cell ghosts with formaldehyde. We found that these rings contracted fully upon exogenous addition of a vertebrate myosin. We conclude that actin turnover is required to maintain actin filament homeostasis during ring contraction and that the requirement for turnover can be bypassed if homeostasis is achieved artificially. PMID:28655757

48 CFR 46.307 - Fixed-price research and development contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Contract Clauses 46.307 Fixed-price research and development... Development—Fixed-Price, in solicitations and contracts for research and development when (1) the primary... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Fixed-price research and...

The effects of crustacean cardioactive peptide on locust oviducts are calcium-dependent.

PubMed

Donini, Andrew; Lange, Angela B

2002-04-01

The role of calcium as a second messenger in the crustacean cardioactive peptide (CCAP)-induced contractions of the locust oviducts was investigated. Incubation of the oviducts in a calcium-free saline containing, a preferential calcium cation chelator, or an extracellular calcium channel blocker, abolished CCAP-induced contractions, indicating that the effects of CCAP on the oviducts are calcium-dependent. In contrast, sodium free saline did not affect CCAP-induced contractions. Co-application of CCAP to the oviducts with preferential L-type voltage-dependent calcium channel blockers reduced CCAP-induced contractions by 32-54%. Two preferential T-type voltage-dependent calcium channel blockers both inhibited CCAP-induced oviduct contractions although affecting different components of the contractions. Amiloride decreased the tonic component of CCAP-induced contractions by 40-55% and flunarizine dihydrochloride decreased the frequency of CCAP-induced phasic contractions by as much as 65%, without affecting tonus. Flunarizine dihydrochloride did not alter the proctolin-induced contractions of the oviducts. Results suggest that the actions of CCAP are partially mediated by voltage-dependent calcium channels similar to vertebrate L-type and T-type channels. High-potassium saline does not abolish CCAP-induced contractions indicating the presence of receptor-operated calcium channels that mediate the actions of CCAP on the oviducts. The involvement of calcium from intracellular stores in CCAP-induced contractions of the oviducts is likely since, an intracellular calcium antagonist decreased CCAP-induced contractions by 30-35%.

Turbine Engine Hot Section Technology (HOST)

NASA Technical Reports Server (NTRS)

1983-01-01

A two-day workshop on the research and plans for turbine engine hot section durability problems was held on October 25 and 26, 1983, at the NASA Lewis Research Center. Presentations were made during six sessions, including structural analysis, fatigue and fracture, surface protective coatings, combustion, turbine heat transfer, and instrumentation, that dealt with the thermal and fluid environment around liners, blades, and vanes, and with material coatings, constitutive behavior, stress-strain response, and life prediction methods for the three components. The principal objective of each session was to disseminate the research results to date, along with future plans, in each of the six areas. Contract and government researchers presented results of their work.

Challenges With Research Contract Negotiations in Community-Based Cancer Research.

PubMed

Thompson, Michael A; Hurley, Patricia A; Faller, Bryan; Longinette, Jean; Richter, Katie; Stewart, Teresa L; Robert, Nicholas

2016-06-01

Community-based research programs face many barriers to participation in clinical trials. Although the majority of people with cancer are diagnosed and treated in the community setting, only roughly 3% are enrolled onto clinical trials. Research contract and budget negotiations have been consistently identified as time consuming and a barrier to participation in clinical trials. ASCO's Community Research Forum conducted a survey about specific challenges of research contract and budget negotiation processes in community-based research settings. The goal was to ultimately identify potential solutions to these barriers. A survey was distributed to 780 community-based physician investigators and research staff. The survey included questions to provide insight into contract and budget negotiation processes and perceptions about related barriers. A total of 77% of the 150 respondents acknowledged barriers in the process. Respondents most frequently identified budget-related issues (n = 133), inefficiencies in the process (n = 80), or legal review and negotiation issues (n = 70). Of the respondents, 44.1% indicated that contract research organizations made the contract negotiations process harder for their research program, and only 5% believed contract research organizations made the process easier. The contract negotiations process is perceived to be impeded by sponsors through underestimation of costs, lack of flexibility with the contract language, and excessive delays. Improving clinical trial activation processes and reducing inefficiencies would be beneficial to all interested stakeholders, including patients who may ultimately stand to benefit from participation in clinical trials. The following key recommendations were made: standardization of contracts and negotiation processes to promulgate transparency and efficiencies, improve sponsor processes to minimize burden on sites, create and promote use of contract templates and best practices, and provide education and consultation. Copyright © 2016 by American Society of Clinical Oncology.

48 CFR 235.072 - Additional contract clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 252.235-7011, Final Scientific or Technical Report, in solicitations and contracts for research and... SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235... involving research on live vertebrate animals. (b) Use the clause at 252.235-7003, Frequency Authorization...

48 CFR 235.072 - Additional contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 252.235-7011, Final Scientific or Technical Report, in solicitations and contracts for research and... SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235... involving research on live vertebrate animals. (b) Use the clause at 252.235-7003, Frequency Authorization...

48 CFR 904.7004 - Findings, determination, and contract award or termination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... that award of a contract to an offeror(s) or continued performance of a contract by a contractor will... types of plans that a contractor can propose are: measures which provide for physical or organizational separation of the facility or organizational component containing the classified information or special...

A Motivation Contract Model of Employee Appraisal.

ERIC Educational Resources Information Center

Glenn, Robert B.

The purpose of this paper is to develop a process model for identification and assessment of employee job performance, through motivation contracting. The model integrated various components of expectancy theories of motivation and performance contracting and is based on humanistic assumptions about the nature of people. More specifically, the…

26 CFR 1.460-5 - Cost allocation rules.

Code of Federal Regulations, 2010 CFR

2010-04-01

... must be allocated to a long-term contract when dedicated to the contract under principles similar to... component is dedicated, under principles similar to those in § 1.263A-11(b)(2). A taxpayer maintaining... exempt construction contract reported using the CCM— (A) Marketing and selling expenses, including...

Contracting in vivo research: what are the issues?

PubMed

Underwood, Wendy J

2007-07-01

As a result of increasing internal and external pressures, research institutions are using contract research organizations for the conduct of in vivo research. Many issues arise when contracting animal research, including concern regarding animal health and welfare. Each sponsor institution should develop a program for outsourced in vivo research that evaluates and ensures appropriate care and use of research animals. Each sponsoring institution should consider establishing a policy and procedure for how outsourced in vivo studies will be approved, conducted, and monitored. An approved list of contract facilities can be established on the basis of accepted standards for animal care and use. Written contracts should include confidentiality agreements, the delineation of animal ownership, and the expectation to comply with all applicable regulations and guidelines for research animal care and use. Finally, a process for communication of adverse study or animal welfare events should be established. Thorough evaluation of contract organizations will help ensure appropriate research animal care and use.

Flight service evaluation of composite helicopter components

NASA Technical Reports Server (NTRS)

Mardoian, George H.; Ezzo, Maureen B.

1994-01-01

This paper presents the results of a NASA funded contract and Sikorsky research and development programs to evaluate structural composite components in flight service on Sikorsky Model S-76 helicopters. Selected components were removed and tested at prescribed intervals over a nine year time frame. Four horizontal stabilizers and thirteen tail rotor spars were returned from commercial service in West Palm Beach, Florida and in the Gulf Coast region of Louisiana to determine the long term effects of operations in hot and humid climates on component performance. Concurrent with the flight component evaluation, panels of materials used in their fabrication were exposed to the environment in ground racks. Selected panels were tested annually to determine the effects of exposure on physical and mechanical properties. The results of 55,741 component flight hours and 911 months of field exposure are reported and compared with initial Federal Aviation Administration (FAA) certification data. The findings of this program have provided increased confidence in the long term durability of advanced composite materials used in helicopter structural applications.

Alternative aircraft fuels technology

NASA Technical Reports Server (NTRS)

Grobman, J.

1976-01-01

NASA is studying the characteristics of future aircraft fuels produced from either petroleum or nonpetroleum sources such as oil shale or coal. These future hydrocarbon based fuels may have chemical and physical properties that are different from present aviation turbine fuels. This research is aimed at determining what those characteristics may be, how present aircraft and engine components and materials would be affected by fuel specification changes, and what changes in both aircraft and engine design would be required to utilize these future fuels without sacrificing performance, reliability, or safety. This fuels technology program was organized to include both in-house and contract research on the synthesis and characterization of fuels, component evaluations of combustors, turbines, and fuel systems, and, eventually, full-scale engine demonstrations. A review of the various elements of the program and significant results obtained so far are presented.

A review of mixing and propulsion of chyme in the small intestine: fresh insights from new methods.

PubMed

Lentle, R G; de Loubens, C

2015-05-01

The small intestine is a convoluted flexible tube of inconstant form and capacity through which chyme is propelled and mixed by varying patterns of contraction. These inconstancies have prevented quantitative comparisons of the manner in which contractile activity engenders mixing of contained chyme. Recent quantitative work based on spatiotemporal mapping of intestinal contractions, macro- and micro-rheology, particle image velocimetry and real-time modelling has provided new insights into this process. Evidence indicates that the speeds and patterns of the various types of small intestinal contraction are insufficient to secure optimal mixing and enzymatic digestion over a minimal length of intestine. Hence particulate substrates and soluble nutrients become dispersed along the length of the lumen. Mixing within the lumen is not turbulent but results from localised folding and kneading of the contents by contractions but is augmented by the inconstant spatial disposition of the contractions and their component contractile processes. The latter include inconstancies in the sites of commencement and the directions of propagation of contraction in component groups of smooth muscle cells and in the coordination of the radial and circular components of smooth muscle contraction. Evidence suggests there is ongoing augmentation of mixing at the periphery of the lumen, during both the post-prandial and inter-meal periods, to promote flow around and between adjacent villi. This results largely from folding of the relatively inelastic mucosa during repeated radial and longitudinal muscular contraction, causing chyme to be displaced by periodic crowding and separation of the tips of the relatively rigid villi. Further, micro-rheological studies indicate that such peripheral mixing may extend to the apices of enterocytes owing to discontinuities in the mobile mucus layer that covers the ileal mucosa.

Composite Sandwich Technologies Lighten Components

NASA Technical Reports Server (NTRS)

2010-01-01

Leveraging its private resources with several Small Business Innovation Research (SBIR) contracts with both NASA and the U.S. Department of Defense, WebCore Technologies LLC, of Miamisburg, Ohio, developed a fiber-reinforced foam sandwich panel it calls TYCOR that can be used for a wide variety of industrial and consumer applications. Testing at Glenn Research Center?s Ballistic Impact Facility demonstrated that the technology was able to exhibit excellent damage localization and stiffness during impact. The patented and trademarked material has found use in many demanding applications, including marine, ground transportation, mobile shelters, bridges, and most notably, wind turbines.

Role of the Z band in the mechanical properties of the heart.

PubMed

Goldstein, M A; Schroeter, J P; Michael, L H

1991-05-01

In striated muscle the mechanism of contraction involves the cooperative movement of contractile and elastic components. This review emphasizes a structural approach that describes the cellular and extracellular components with known anatomical, biochemical, and physical properties that make them candidates for these contractile and elastic components. Classical models of contractile and elastic elements and their underlying assumptions are presented. Mechanical properties of cardiac and skeletal muscle are compared and contrasted and then related to ultrastructure. Information from these approaches leads to the conclusion that the Z band is essential for muscle contraction. Our review of Z band structure shows the Z band at the interface where extracellular components meet the cell surface. The Z band is also the interface from cell surface to myofibril, from extra-myofibrillar to myofibril, and finally from sarcomere to sarcomere. Our studies of Z band in defined physiologic states show that this lattice is an integral part of the contractile elements and can function as an elastic component. The Z band is a complex dynamic lattice uniquely suited to play several roles in muscle contraction.

Contract Research, the University, and the Academic.

ERIC Educational Resources Information Center

Crawshaw, Bruce

1985-01-01

Implications of the growth of university-based contract research are examined, including moral and ethical issues, legal aspects, ownership of research results, staff rights, researcher status, publication, authority, responsibility, social justice, and conflicts between teaching and research. Eleven suggestions for successful contract research…

48 CFR 27.406-2 - Additional data requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., research, or demonstration contracts, it may not be feasible to ascertain all the data requirements at... basic or applied research to be performed under a contract solely by a university or college when the... research to be performed by a university or college, and the contracting officer believes the contract...

48 CFR 27.406-2 - Additional data requirements.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., research, or demonstration contracts, it may not be feasible to ascertain all the data requirements at... basic or applied research to be performed under a contract solely by a university or college when the... research to be performed by a university or college, and the contracting officer believes the contract...

Propofol preferentially relaxes neurokinin receptor-2-induced airway smooth muscle contraction in guinea pig trachea.

PubMed

Gleason, Neil R; Gallos, George; Zhang, Yi; Emala, Charles W

2010-06-01

Propofol is the anesthetic of choice for patients with reactive airway disease and is thought to reduce intubation- or irritant-induced bronchoconstriction by decreasing the cholinergic component of vagal nerve activation. However, additional neurotransmitters, including neurokinins, play a role in irritant-induced bronchoconstriction. We questioned the mechanistic assumption that the clinically recognized protective effect of propofol against irritant-induced bronchoconstriction during intubation was due to attenuation of airway cholinergic reflexes. Muscle force was continuously recorded from isolated guinea pig tracheal rings in organ baths. Rings were subjected to exogenous contractile agonists (acetylcholine, histamine, endothelin-1, substance P, acetyl-substance P, and neurokinin A) or to electrical field stimulation (EFS) to differentiate cholinergic or nonadrenergic, noncholinergic nerve-mediated contraction with or without cumulatively increasing concentrations of propofol, thiopental, etomidate, or ketamine. Propofol did not attenuate the cholinergic component of EFS-induced contraction at clinically relevant concentrations. In contrast, propofol relaxed nonadrenergic, noncholinergic-mediated EFS contraction at concentrations within the clinical range (20-100 mum, n = 9; P < 0.05), and propofol was more potent against an exogenous selective neurokinin-2 receptor versus neurokinin-1 receptor agonist contraction (n = 6, P < 0.001). Propofol, at clinically relevant concentrations, relaxes airway smooth muscle contracted by nonadrenergic, noncholinergic-mediated EFS and exogenous neurokinins but not contractions elicited by the cholinergic component of EFS. These findings suggest that the mechanism of protective effects of propofol against irritant-induced bronchoconstriction involves attenuation of tachykinins released from nonadrenergic, noncholinergic nerves acting at neurokinin-2 receptors on airway smooth muscle.

48 CFR 10.003 - Contract clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... MARKET RESEARCH 10.003 Contract clause. The contracting officer shall insert the clause at 52.210-1, Market Research, in solicitations and contracts over $5 million for the procurement of items other than...

Modification of Personal Hygiene and Grooming Behaviors with Contingency Contracting: A Brief Review and Case Study.

ERIC Educational Resources Information Center

Allen, Sarah J.; Kramer, Jack J.

1990-01-01

Presents discussion of basic components and characteristics of contingency contracts. Includes case study in which contingency contracting procedures were integrated within a behavioral consultation model used by a school psychologist consulting with a classroom teacher to modify personal hygiene of 12-year-old male. (Author/ABL)

Protein kinase C may regulate the tonic component of intestinal smooth muscle contraction in response to substance P.

PubMed

Holzer, P; Lippe, I T

1989-01-01

(1) The study investigated a possible involvement of protein kinase C (PKC) in the substance P-induced contraction of the longitudinal muscle of the guinea-pig isolated ileum. (2) The predominant effect of the PKC activator, phorbol-12,13-dibutyrate (PDB), was to change the time course of the response to substance P. While the initial peak contraction was hardly influenced by PDB, the fading of the contraction was accelerated to an extent that any tonic contraction which normally followed the initial peak response was prevented. This inhibitory effect of PDB on the tonic contraction was immediate in onset and related to its concentration (20-200 nM); responses to half-maximally (2-7 nM) or maximally effective (0.74 microM) concentrations of substance P were affected in the same manner. Tetrodotoxin (0.6 microM) did not alter the effect of PDB. Phorbol-13-monoacetate (2 microM), a phorbol ester which does not stimulate PKC, failed to change the time course of the substance P-induced contraction. (3) The tonic component of half-maximal contractile responses to histamine (0.2-0.4 microM) was also depressed by PDB (0.2 microM) whereas the tonic component of maximal responses to histamine (9 microM) was enhanced. (4) PDB (0.2 microM) reduced desensitization to substance P as judged by the reduction of the peak response to substance P (2-7 nM) following a 10-min exposure to a high concentration of the peptide (0.74 microM). (5) The PKC inhibitor, polymyxin B (0.1-0.3 mM), reduced the peak contractile response to substance P, slowed the fading of the contraction, and antagonized the inhibitory effect of PDB on the tonic contraction.(ABSTRACT TRUNCATED AT 250 WORDS)

United States Navy Contracting Officer Warranting Process

DTIC Science & Technology

2011-03-01

by 30% or more of the respondents: Contract Law , Cost Analysis, Market Research, Contract Source Selection, Simplified Acquisition Procedures, and...that the majority of AOs found the following course at least somewhat important: Contract Law , Cost Analysis, Market Research, Contract 52 Source...the budget and appropriation cycle 4. Ethics and conduct standards 5. Basic contract laws and regulations 6. Socio-economic requirements in

48 CFR 235.015-70 - Special use allowances for research facilities acquired by educational institutions.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., acquired for the purpose of conducting scientific research under contracts with departments and agencies of... research facilities acquired by educational institutions. 235.015-70 Section 235.015-70 Federal Acquisition... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.015-70 Special use allowances for research facilities...

48 CFR 235.015-70 - Special use allowances for research facilities acquired by educational institutions.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., acquired for the purpose of conducting scientific research under contracts with departments and agencies of... research facilities acquired by educational institutions. 235.015-70 Section 235.015-70 Federal Acquisition... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.015-70 Special use allowances for research facilities...

48 CFR 235.015-70 - Special use allowances for research facilities acquired by educational institutions.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., acquired for the purpose of conducting scientific research under contracts with departments and agencies of... research facilities acquired by educational institutions. 235.015-70 Section 235.015-70 Federal Acquisition... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.015-70 Special use allowances for research facilities...

48 CFR 846.302-70 - Guarantee clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... MANAGEMENT QUALITY ASSURANCE Contract Clauses 846.302-70 Guarantee clause. (a) The contracting officer shall... installation shall be borne by the Government. Where it is industry policy to guarantee components for the life...

48 CFR 846.302-70 - Guarantee clause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... MANAGEMENT QUALITY ASSURANCE Contract Clauses 846.302-70 Guarantee clause. (a) The contracting officer shall... installation shall be borne by the Government. Where it is industry policy to guarantee components for the life...

Design a Contract: A Simple Principal-Agent Problem as a Classroom Experiment

ERIC Educational Resources Information Center

Gachter, Simon; Konigstein, Manfred

2009-01-01

The authors present a simple classroom experiment that can be used as a teaching device to introduce important concepts of organizational economics and incentive contracting. First, students take the role of a principal and design a contract that consists of a fixed payment and an incentive component. Second, students take the role of agents and…

48 CFR 15.604 - Agency points of contact.

Code of Federal Regulations, 2010 CFR

2010-10-01

... agency: upcoming solicitations; Broad Agency Announcements; Small Business Innovation Research programs; Small Business Technology Transfer Research programs; Program Research and Development Announcements; or... CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Unsolicited Proposals 15.604 Agency points...

A Winning Cast

NASA Technical Reports Server (NTRS)

2001-01-01

Howmet Research Corporation was the first to commercialize an innovative cast metal technology developed at Auburn University, Auburn, Alabama. With funding assistance from NASA's Marshall Space Flight Center, Auburn University's Solidification Design Center (a NASA Commercial Space Center), developed accurate nickel-based superalloy data for casting molten metals. Through a contract agreement, Howmet used the data to develop computer model predictions of molten metals and molding materials in cast metal manufacturing. Howmet Metal Mold (HMM), part of Howmet Corporation Specialty Products, of Whitehall, Michigan, utilizes metal molds to manufacture net shape castings in various alloys and amorphous metal (metallic glass). By implementing the thermophysical property data from by Auburn researchers, Howmet employs its newly developed computer model predictions to offer customers high-quality, low-cost, products with significantly improved mechanical properties. Components fabricated with this new process replace components originally made from forgings or billet. Compared with products manufactured through traditional casting methods, Howmet's computer-modeled castings come out on top.

A new approach to the human muscle model.

PubMed

Baildon, R W; Chapman, A E

1983-01-01

Hill's (1938) two component muscle model is used as basis for digital computer simulation of human muscular contraction by means of an iterative process. The contractile (CC) and series elastic (SEC) components are lumped components of structures which produce and transmit torque to the external environment. The CC is described in angular terms along four dimensions as a series of non-planar torque-angle-angular velocity surfaces stacked on top of each other, each surface being appropriate to a given level of muscular activation. The SEC is described similarly along dimensions of torque, angular stretch, overall muscle angular displacement and activation. The iterative process introduces negligible error and allows the mechanical outcome of a variety of normal muscular contractions to be evaluated parsimoniously. The model allows analysis of many aspects of muscle behaviour as well as optimization studies. Definition of relevant relations should also allow reproduction and prediction of the outcome of contractions in individuals.

Department of Defense picture archiving and communication system acceptance testing: results and identification of problem components.

PubMed

Allison, Scott A; Sweet, Clifford F; Beall, Douglas P; Lewis, Thomas E; Monroe, Thomas

2005-09-01

The PACS implementation process is complicated requiring a tremendous amount of time, resources, and planning. The Department of Defense (DOD) has significant experience in developing and refining PACS acceptance testing (AT) protocols that assure contract compliance, clinical safety, and functionality. The DOD's AT experience under the initial Medical Diagnostic Imaging Support System contract led to the current Digital Imaging Network-Picture Archiving and Communications Systems (DIN-PACS) contract AT protocol. To identify the most common system and component deficiencies under the current DIN-PACS AT protocol, 14 tri-service sites were evaluated during 1998-2000. Sixteen system deficiency citations with 154 separate types of limitations were noted with problems involving the workstation, interfaces, and the Radiology Information System comprising more than 50% of the citations. Larger PACS deployments were associated with a higher number of deficiencies. The most commonly cited systems deficiencies were among the most expensive components of the PACS.

48 CFR 11.503 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., Liquidated Damages—Supplies, Services, or Research and Development, in fixed-price solicitations and contracts for supplies, services, or research and development when the contracting officer determines that...—Construction, in solicitations and contracts for construction, other than cost-plus-fixed-fee, when the...

48 CFR 242.7001 - Contract clause.

Code of Federal Regulations, 2014 CFR

2014-10-01

... solicitations and contracts (other than in contracts with educational institutions, Federally Funded Research and Development Centers (FFRDCs), or University Associated Research Centers (UARCs) operated by...

48 CFR 242.7001 - Contract clause.

Code of Federal Regulations, 2013 CFR

2013-10-01

... solicitations and contracts (other than in contracts with educational institutions, Federally Funded Research and Development Centers (FFRDCs), or University Associated Research Centers (UARCs) operated by...

48 CFR 242.7001 - Contract clause.

Code of Federal Regulations, 2012 CFR

2012-10-01

... solicitations and contracts (other than in contracts with educational institutions, Federally Funded Research and Development Centers (FFRDCs), or University Associated Research Centers (UARCs) operated by...

Lens positioner with five degrees of freedom

DOEpatents

Kobierecki, Marian W.; Rienecker, Jr., Frederick

1978-01-01

A device for positioning lenses precisely with five degrees of freedom (three translations and two angular rotations). The unique features of the device are its compact design, large clear aperture, and high degree of positioning accuracy combined with five degrees of freedom in axis motion. Thus, the device provides precision and flexibility in positioning of optical components. BACKGROUND OF THE INVENTION The invention described herein was made in the course of, or under, Contract No. AT(29-1)-1183, with the United States Energy Research and Development Administration.

A Comparative Analysis of Patient Access Modes at Wilford Hall United States Air Force Medical Center and Selected Civilian Medical Centers

DTIC Science & Technology

1983-12-01

system is the provision of quality health care to patients . In recognition of this fundamental component of the social contract, executive management...deemed it necessary to request research be conducted to assure there were responsive and efficient patient access modes to health care services at...each of the other observed facilities. 2. The demand for health care by the patient population, seeking access to similar clinics or services at each of

Space Mechanisms Lessons Learned and Accelerated Testing Studies

NASA Technical Reports Server (NTRS)

Fusaro, Robert L.

1997-01-01

A number of mechanism (mechanical moving component) failures and anomalies have recently occurred on satellites. In addition, more demanding operating and life requirements have caused mechanism failures or anomalies to occur even before some satellites were launched (e.g., during the qualification testing of GOES-NEXT, CERES, and the Space Station Freedom Beta Joint Gimbal). For these reasons, it is imperative to determine which mechanisms worked in the past and which have failed so that the best selection of mechanically moving components can be made for future satellites. It is also important to know where the problem areas are so that timely decisions can be made on the initiation of research to develop future needed technology. To chronicle the life and performance characteristics of mechanisms operating in a space environment, a Space Mechanisms Lessons Learned Study was conducted. The work was conducted by the NASA Lewis Research Center and by Mechanical Technologies Inc. (MTI) under contract NAS3-27086. The expectation of the study was to capture and retrieve information relating to the life and performance of mechanisms operating in the space environment to determine what components had operated successfully and what components had produced anomalies.

Strategic drivers of contract manufacturing: Part I, The theory.

PubMed

Tomlinson, Geoff; Geimer, Harald

2002-12-01

Medical device manufacturers and diagnostics companies have significantly increased their use of contract manufacturers to outsource production of components. This, the first of a two-part article, reviews strategic benefits and best practices in outsourcing.

Innovative Techniques Simplify Vibration Analysis

NASA Technical Reports Server (NTRS)

2010-01-01

In the early years of development, Marshall Space Flight Center engineers encountered challenges related to components in the space shuttle main engine. To assess the problems, they evaluated the effects of vibration and oscillation. To enhance the method of vibration signal analysis, Marshall awarded Small Business Innovation Research (SBIR) contracts to AI Signal Research, Inc. (ASRI), in Huntsville, Alabama. ASRI developed a software package called PC-SIGNAL that NASA now employs on a daily basis, and in 2009, the PKP-Module won Marshall s Software of the Year award. The technology is also used in many industries: aircraft and helicopter, rocket engine manufacturing, transportation, and nuclear power."

Hospital contract management: a descriptive profile.

PubMed Central

Alexander, J A; Lewis, B L

1984-01-01

Despite the dramatic growth in hospital contract management in the last decade, research only recently has begun to provide insights into the structure, operation, and effectiveness of these arrangements. Two descriptive questions regarding hospital contract management are addressed in an effort to increase correspondence between theoretical and evaluative research in this area: (1) how do contract-managed hospitals differ from traditionally managed hospitals? and (2) how do contract-managed hospitals differ from each other? Principal discriminating variables in the analyses are hospital size, control, urban-rural location, region, management organization control, and management organization size. Results of the analysis on a sample of 406 contract-managed hospitals and 401 unaffiliated hospitals reveal important differences between contract-managed and traditionally managed hospitals as well as among contract management organizations. These findings are discussed in terms of their implications for future research and performance evaluations on contract management arrangements. PMID:6490376

Modulation of contraction by intracellular Na+ via Na(+)-Ca2+ exchange in single shark (Squalus acanthias) ventricular myocytes.

PubMed Central

Näbauer, M; Morad, M

1992-01-01

1. The effect of direct alteration of intracellular Na+ concentration on contractile properties of whole-cell clamped shark ventricular myocytes was studied using an array of 256 photodiodes to monitor the length of the isolated myocytes. 2. In myocytes dialysed with Na(+)-free solution, the voltage dependence of Ca2+ current (ICa) and contraction were similar and bell shaped. Contractions activated at all voltages were completely suppressed by nifedipine (5 microM), and failed to show significant tonic components, suggesting dependence of the contraction on Ca2+ influx through the L-type Ca2+ channel. 3. In myocytes dialysed with 60 mM Na+, a ICa-dependent and a ICa-independent component of contraction could be identified. The Ca2+ current-dependent component was prominent in voltages between -30 to +10 mV. The ICa-independent contractions were maintained for the duration of depolarization, increased with increasing depolarization between +10 to +100 mV, and were insensitive to nifedipine. 4. In such myocytes, repolarization produced slowly decaying inward tail currents closely related to the time course of relaxation and the degree of shortening prior to repolarization. 5. With 60 mM Na+ in the pipette solution, positive clamp potentials activated decaying outward currents which correlated to the size of contraction. These outward currents appeared to be generated by the Na(+)-Ca(2+)-exchanger since they depended on the presence of intracellular Na+, and were neither suppressed by nifedipine nor by K+ channel blockers. 6. The results suggest that in shark (Squalus acanthias) ventricular myocytes, which lack functionally relevant Ca2+ release pools, both Ca2+ channel and the Na(+)-Ca2+ exchanger deliver sufficient Ca2+ to activate contraction, though the effectiveness of the latter mechanism was highly dependent on the [Na+]i. PMID:1338467

Phorbol esters inhibit smooth muscle contractions through activation of Na(+)-K(+)-ATPase.

PubMed Central

Sasaguri, T.; Watson, S. P.

1990-01-01

1. The role of protein kinase C (PKC) in agonist-induced contractions of guinea-pig ileum longitudinal smooth muscle has been investigated. 2. The phorbol esters, phorbol 12,13-dibutyrate (PDBu), phorbol 12,13-diacetate (PDA) and phorbol 12-myristate 13-acetate (PMA), relaxed tissues precontracted by submaximal concentrations of carbachol, histamine or substance P. 3. This inhibitory action of the phorbol esters was reversed following the application of ouabain, a specific inhibitor of Na(+)-K(+)-ATPase. Similarly, pretreatment with ouabain inhibited the ability of phorbol esters to relax tissues precontracted by the above agonists. 4. The slow relaxation of the tonic component of contraction induced by submaximal concentrations of carbachol and histamine, and all concentrations of substance P, was abolished in the presence of ouabain. 5. In Na(+)-loaded tissues, PDBu and carbachol caused a concentration-dependent increase of Na(+)-K(+)-ATPase activity, assessed by ouabain-sensitive 86Rb(+)-uptake. Extrusion of Na+, assessed by the cellular content of the ion, was also stimulated by PDBu (the effect of carbachol was not investigated). 6. We conclude that phorbol esters inhibit the tonic component of contractions induced by submaximal concentrations of these agonists through activation of Na(+)-K(+)-ATPase. We suggest that PKC may exert feedback control over the tonic component of agonist contractions through stimulation of the pump. PMID:1691673

21 CFR 312.52 - Transfer of obligations to a contract research organization.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 5 2011-04-01 2011-04-01 false Transfer of obligations to a contract research... and Investigators § 312.52 Transfer of obligations to a contract research organization. (a) A sponsor... research organization. Any such transfer shall be described in writing. If not all obligations are...

48 CFR 35.014 - Government property and title.

Code of Federal Regulations, 2011 CFR

2011-10-01

... basic or applied scientific research, apply to contracts with nonprofit institutions of higher education and nonprofit organizations whose primary purpose is the conduct of scientific research: (1) If the... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.014 Government property and...

48 CFR 2415.605-70 - Unsolicited research proposals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Unsolicited research... URBAN DEVELOPMENT CONTRACTING METHODS AND CONTRACTING TYPES CONTRACTING BY NEGOTIATION Source Selection 2415.605-70 Unsolicited research proposals. FAR subpart 15.6 outlines the policies and procedures...

48 CFR 1815.403-170 - Waivers of cost or pricing data.

Code of Federal Regulations, 2010 CFR

2010-10-01

... data when contracting for Small Business Innovation Research (SBIR) program Phase II contracts. However... SPACE ADMINISTRATION CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing...

[Claim and reality of selective contact options : experiences in finalizing selective contracts in urological care].

PubMed

Ex, P; Schroeder, A

2014-08-01

Selective contracts are an important component in addition to the total healthcare concept in order to introduce process-related innovations into the healthcare system. Since 2011 the Berufsverband der Deutschen Urologen (BDU, Professional Association of German Urologists) has held negotiations with individual health insurance companies and care providers in order to view selective contracts as collective contracts, not only as pilot projects but also as additional forms of care.This article illustrates the experiences of the BDU in the initiation and finalizing of selective contracts as well as existing weak points in the framework conditions.

Additive manufacture (3d printing) of plasma diagnostic components and assemblies for fusion experiments

NASA Astrophysics Data System (ADS)

Sieck, Paul; Woodruff, Simon; Stuber, James; Romero-Talamas, Carlos; Rivera, William; You, Setthivoine; Card, Alexander

2015-11-01

Additive manufacturing (or 3D printing) is now becoming sufficiently accurate with a large range of materials for use in printing sensors needed universally in fusion energy research. Decreasing production cost and significantly lowering design time of energy subsystems would realize significant cost reduction for standard diagnostics commonly obtained through research grants. There is now a well-established set of plasma diagnostics, but these expensive since they are often highly complex and require customization, sometimes pace the project. Additive manufacturing (3D printing) is developing rapidly, including open source designs. Basic components can be printed for (in some cases) less than 1/100th costs of conventional manufacturing. We have examined the impact that AM can have on plasma diagnostic cost by taking 15 separate diagnostics through an engineering design using Conventional Manufacturing (CM) techniques to determine costs of components and labor costs associated with getting the diagnostic to work as intended. With that information in hand, we set about optimizing the design to exploit the benefits of AM. Work performed under DOE Contract DE-SC0011858.

On 3-D inelastic analysis methods for hot section components. Volume 1: Special finite element models

NASA Technical Reports Server (NTRS)

Nakazawa, S.

1988-01-01

This annual status report presents the results of work performed during the fourth year of the 3-D Inelastic Analysis Methods for Hot Section Components program (NASA Contract NAS3-23697). The objective of the program is to produce a series of new computer codes permitting more accurate and efficient 3-D analysis of selected hot section components, i.e., combustor liners, turbine blades and turbine vanes. The computer codes embody a progression of math models and are streamlined to take advantage of geometrical features, loading conditions, and forms of material response that distinguish each group of selected components. Volume 1 of this report discusses the special finite element models developed during the fourth year of the contract.

48 CFR 970.35 - Research and development contracting.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Research and development contracting. 970.35 Section 970.35 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Major System Acquisition 970.35 Research and...

48 CFR 970.35 - Research and development contracting.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Research and development contracting. 970.35 Section 970.35 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Major System Acquisition 970.35 Research and...

48 CFR 970.35 - Research and development contracting.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Research and development contracting. 970.35 Section 970.35 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Major System Acquisition 970.35 Research and...

48 CFR 970.35 - Research and development contracting.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Research and development contracting. 970.35 Section 970.35 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Major System Acquisition 970.35 Research and...

10 CFR 733.8 - Contracting officer procedures.

Code of Federal Regulations, 2012 CFR

2012-01-01

... DEPARTMENT OF ENERGY ALLEGATIONS OF RESEARCH MISCONDUCT § 733.8 Contracting officer procedures. Upon receipt of an allegation of research misconduct by referral under § 733.7, the contracting officer should, by... assistance recipient to act on the allegation consistent with the Research Misconduct requirements in the...

10 CFR 733.8 - Contracting officer procedures.

Code of Federal Regulations, 2010 CFR

2010-01-01

... DEPARTMENT OF ENERGY ALLEGATIONS OF RESEARCH MISCONDUCT § 733.8 Contracting officer procedures. Upon receipt of an allegation of research misconduct by referral under § 733.7, the contracting officer should, by... assistance recipient to act on the allegation consistent with the Research Misconduct requirements in the...

10 CFR 733.8 - Contracting officer procedures.

Code of Federal Regulations, 2014 CFR

2014-01-01

... DEPARTMENT OF ENERGY ALLEGATIONS OF RESEARCH MISCONDUCT § 733.8 Contracting officer procedures. Upon receipt of an allegation of research misconduct by referral under § 733.7, the contracting officer should, by... assistance recipient to act on the allegation consistent with the Research Misconduct requirements in the...

10 CFR 733.8 - Contracting officer procedures.

Code of Federal Regulations, 2013 CFR

2013-01-01

... DEPARTMENT OF ENERGY ALLEGATIONS OF RESEARCH MISCONDUCT § 733.8 Contracting officer procedures. Upon receipt of an allegation of research misconduct by referral under § 733.7, the contracting officer should, by... assistance recipient to act on the allegation consistent with the Research Misconduct requirements in the...

10 CFR 733.8 - Contracting officer procedures.

Code of Federal Regulations, 2011 CFR

2011-01-01

... DEPARTMENT OF ENERGY ALLEGATIONS OF RESEARCH MISCONDUCT § 733.8 Contracting officer procedures. Upon receipt of an allegation of research misconduct by referral under § 733.7, the contracting officer should, by... assistance recipient to act on the allegation consistent with the Research Misconduct requirements in the...

48 CFR 27.406-2 - Additional data requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... solicitations and contracts involving experimental, developmental, research or demonstration work (other than basic or applied research to be performed under a contract solely by a university or college when the..., research, or demonstration contracts, it may not be feasible to ascertain all the data requirements at...

The NASA-Lewis/ERDA Solar Heating and Cooling Technology Program

NASA Technical Reports Server (NTRS)

Couch, J. P.; Bloomfield, H. S.

1975-01-01

The NASA Lewis Research Center plans to carry out a major role in the ERDA Solar Heating and Cooling Program. This role would be to create and test the enabling technology for future solar heating, cooling, and combined heating/cooling systems. The major objectives of the project are to achieve reduction in solar energy system costs, while maintaining adequate performance, reliability, life, and maintenance characteristics. The project approach is to move progressively through component, subsystem, and then system technology advancement phases in parallel with continuing manufacturing cost assessment studies. This approach will be accomplished principally by contract with industry to develop advanced components and subsystems. This advanced hardware will be tested to establish 'technology readiness' both under controlled laboratory conditions and under real sun conditions.

Genetic Variations in SLCO Transporter Genes Contributing to Racial Disparity in Aggressiveness of Prostate Cancer

DTIC Science & Technology

2016-10-01

Contract Specialist U.S. Army Medical Research Acquisition Activity, MCMR- AAA -E, 820 Chandler Street, Fort Detrick, MD 21702-5014 Phone: (301) 619-4018...Funding Agency’s Procuring Contracting/Grants Officer: Ayi Ayayi, Contract Specialist U.S. Army Medical Research Acquisition Activity, MCMR- AAA -E, 820...Ayayi, Contract Specialist, U.S. Army Medical Research Acquisition Activity, MCMR- AAA -E, 820 Chandler Street, Fort Detrick, MD 21702-5014 Phone

48 CFR 235.072 - Additional contract clauses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... contracts for research and development. (d) Use the clause at 252.235-7011, Final Scientific or Technical Report, in solicitations and contracts for research and development. (e) Use the clause at 252.235-7004...

Keratinocyte cytoskeletal roles in cell sheet engineering

PubMed Central

2013-01-01

Background There is an increasing need to understand cell-cell interactions for cell and tissue engineering purposes, such as optimizing cell sheet constructs, as well as for examining adhesion defect diseases. For cell-sheet engineering, one major obstacle to sheet function is that cell sheets in suspension are fragile and, over time, will contract. While the role of the cytoskeleton in maintaining the structure and adhesion of cells cultured on a rigid substrate is well-characterized, a systematic examination of the role played by different components of the cytoskeleton in regulating cell sheet contraction and cohesion in the absence of a substrate has been lacking. Results In this study, keratinocytes were cultured until confluent and cell sheets were generated using dispase to remove the influence of the substrate. The effects of disrupting actin, microtubules or intermediate filaments on cell-cell interactions were assessed by measuring cell sheet cohesion and contraction. Keratin intermediate filament disruption caused comparable effects on cell sheet cohesion and contraction, when compared to actin or microtubule disruption. Interfering with actomyosin contraction demonstrated that interfering with cell contraction can also diminish cell cohesion. Conclusions All components of the cytoskeleton are involved in maintaining cell sheet cohesion and contraction, although not to the same extent. These findings demonstrate that substrate-free cell sheet biomechanical properties are dependent on the integrity of the cytoskeleton network. PMID:23442760

48 CFR 237.102-78 - Market research report guide for improving the tradecraft in services acquisition.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING SERVICE CONTRACTING Service Contracts-General 237.102-78 Market research report... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Market research report...

48 CFR 237.102-78 - Market research report guide for improving the tradecraft in services acquisition.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING SERVICE CONTRACTING Service Contracts-General 237.102-78 Market research report... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Market research report...

48 CFR 237.102-78 - Market research report guide for improving the tradecraft in services acquisition.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING SERVICE CONTRACTING Service Contracts-General 237.102-78 Market research report... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Market research report...

TPV Power Source Using Infrared-Sensitive Cells with Commercially Available Radiant Tube Burner

NASA Astrophysics Data System (ADS)

Fraas, Lewis; Minkin, Leonid; Hui, She; Avery, James; Howells, Christopher

2004-11-01

Over the last several years, JX Crystals has invented and systematically developed the key components for thermophotovoltaic systems. These key components include GaSb infrared sensitive cells, high power density shingle circuits, dielectric filters, and hydrocarbon-fueled radiant tube burners. Most recently, we invented and demonstrated an antireflection (AR)-coated tungsten IR emitter which when integrated with the other key components should make TPV systems with efficiencies over 10% practical. However, the use of the AR tungsten emitter requires an oxygen-free hermetic seal enclosure. During a 2003 Small Business Innovative Research (SBIR) Phase I contract, we integrated a tungsten emitter foil and a commercial SiC radiant tube burner within an emitter thermos and successfully demonstrated its operation at high temperature. We also designed a complete stand alone 500 W TPV generator. During the upcoming SBIR Phase II, we plan to implement this design in hardware.

Guidelines for cost control and analysis of cost-type research and development contracts

NASA Technical Reports Server (NTRS)

Sibbers, C. W.

1981-01-01

The cost information which should be obtained from a contractor(s) on a major, cost type research and development contract(s), and the analyses and effective use of these data are discussed. Specific type(s) of information which should be required, methods for analyzing such information, and methods for effectively using the results of such analyses to enhance NASA contract and project management are included. The material presented is based primarily on the principal methods which have been effectively used in the management of major cost type research and development contracts.

48 CFR 225.901 - Policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

... (end products and components); (2) Eligible products (end products but not components) under contracts covered by the World Trade Organization Government Procurement Agreement or a Free Trade Agreement; and (3...

48 CFR 225.901 - Policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

... (end products and components); (2) Eligible products (end products but not components) under contracts covered by the World Trade Organization Government Procurement Agreement or a Free Trade Agreement; and (3...

48 CFR 225.901 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... (end products and components); (2) Eligible products (end products but not components) under contracts covered by the World Trade Organization Government Procurement Agreement or a Free Trade Agreement; and (3...

48 CFR 45.107 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Alternate II when a contract for the conduct of basic or applied research at nonprofit institutions of... research (see 35.014) is contemplated. (b) The contracting officer shall also insert the clause at 52.245-2...

Advanced Gas Turbine (AGT) Technology Development Project, ceramic component developments

NASA Technical Reports Server (NTRS)

Teneyck, M. O.; Macbeth, J. W.; Sweeting, T. B.

1987-01-01

The ceramic component technology development activity conducted by Standard Oil Engineered Materials Company while performing as a principal subcontractor to the Garrett Auxiliary Power Division for the Advanced Gas Turbine (AGT) Technology Development Project (NASA Contract DEN3-167) is summarized. The report covers the period October 1979 through July 1987, and includes information concerning ceramic technology work categorized as common and unique. The former pertains to ceramic development applicable to two parallel AGT projects established by NASA contracts DEN3-168 (AGT100) and DEN3-167 (AGT101), whereas the unique work solely pertains to Garrett directed activity under the latter contract. The AGT101 Technology Development Project is sponsored by DOE and administered by NASA-Lewis. Standard Oil directed its efforts toward the development of ceramic materials in the silicon-carbide family. Various shape forming and fabrication methods, and nondestructive evaluation techniques were explored to produce the static structural components for the ceramic engine. This permitted engine testing to proceed without program slippage.

Structural hysteresis in dragline spider silks induced by supercontraction: an X-ray fiber micro-diffraction study

DOE PAGES

Sampath, Sujatha; Yarger, Jeffery L.

2014-11-27

Interaction with water causes shrinkage and significant changes in the structure of spider dragline silks, which has been referred to as supercontraction in the literature. Preferred orientation or alignment of protein chains with respect to the fiber axis is extensively changed during this supercontraction process. Synchrotron X-ray micro-fiber diffraction experiments have been performed on Nephila clavipes and Argiope aurantia major and minor ampullate dragline spider fibers in the native dry, contracted (by immersion in water) and restretched (from contracted) states. Changes in the orientation of β-sheet nanocrystallites and the oriented component of the amorphous network have been determined from wide-anglemore » X-ray diffraction patterns. While both the crystalline and amorphous components lose preferred orientation on wetting with water, the nano-crystallites regain their orientation on wet-restretching, whereas the oriented amorphous components only partially regain their orientation. Dragline major ampullate silks in both the species contract more than their minor ampullate silks.« less

Modification of selected South Carolina bridge-scour envelope curves

USGS Publications Warehouse

Benedict, Stephen T.; Caldwell, Andral W.

2012-01-01

Historic scour was investigated at 231 bridges in the Piedmont and Coastal Plain physiographic provinces of South Carolina by the U.S. Geological Survey in cooperation with the South Carolina Department of Transportation. These investigations led to the development of field-derived envelope curves that provided supplementary tools to assess the potential for scour at bridges in South Carolina for selected scour components that included clear-water abutment, contraction, and pier scour, and live-bed pier and contraction scour. The envelope curves consist of a single curve with one explanatory variable encompassing all of the measured field data for the respective scour components. In the current investigation, the clear-water abutment-scour and live-bed contraction-scour envelope curves were modified to include a family of curves that utilized two explanatory variables, providing a means to further refine the assessment of scour potential for those specific scour components. The modified envelope curves and guidance for their application are presented in this report.

77 FR 47797 - Federal Acquisition Regulation; Small Business Set Asides for Research and Development Contracts

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-10

... Acquisition Regulation; Small Business Set Asides for Research and Development Contracts AGENCY: Department of... Acquisition Regulation (FAR) to clarify that contracting officers shall set aside acquisitions for research..., and NASA are proposing to amend the Federal Acquisition Regulation (FAR) to revise paragraph (b)(2) of...

48 CFR 250.104-3-70 - Indemnification under contracts involving both research and development and other work.

Code of Federal Regulations, 2010 CFR

2010-10-01

... contracts involving both research and development and other work. 250.104-3-70 Section 250.104-3-70 Federal... MANAGEMENT EXTRAORDINARY CONTRACTUAL ACTIONS AND THE SAFETY ACT Extraordinary Contractual Actions 250.104-3-70 Indemnification under contracts involving both research and development and other work. When...

48 CFR 211.274-6 - Contract clauses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Contract clauses. 211.274-6 Section 211.274-6 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... subassemblies, components, or parts embedded within deliverable items. (4) Use the clause with its Alternate I...

48 CFR 211.274-6 - Contract clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Contract clauses. 211.274-6 Section 211.274-6 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... subassemblies, components, or parts embedded within deliverable items. (4) Use the clause with its Alternate I...

48 CFR 35.001 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.001 Definitions. Applied research means the effort that (a) normally follows basic research, but may not be severable from the related basic research; (b) attempts to...

48 CFR 16.103 - Negotiating contract type.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Selecting Contract Types 16.103 Negotiating contract... basic profit motive of business enterprise, shall be used when the risk involved is minimal or can be...) Contracts on a firm fixed-price basis other than those for major systems or research and development, and (3...

48 CFR 917.7301-1 - General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 917.7301-1 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Program Research and Development Announcements 917.7301-1... in entering into arrangements for research, development, and related projects in specified areas of...

Establishing guidelines for incentive/disincentive contracting at ODOT.

DOT National Transportation Integrated Search

2007-02-01

This report describes the results of a research project which explored the use of Incentive / Disincentive (I/D) contracting at : the Oregon Department of Transportation (ODOT). The research found that I/D contracting is a relatively rare practice : ...

European Extremely Large Telescope: progress report

NASA Astrophysics Data System (ADS)

Tamai, R.; Spyromilio, J.

2014-07-01

The European Extremely Large Telescope is a project of the European Southern Observatory to build and operate a 40-m class optical near-infrared telescope. The telescope design effort is largely concluded and construction contracts are being placed with industry and academic/research institutes for the various components. The siting of the telescope in Northern Chile close to the Paranal site allows for an integrated operation of the facility providing significant economies. The progress of the project in various areas is presented in this paper and references to other papers at this SPIE meeting are made.

Testing of motor unit synchronization model for localized muscle fatigue.

PubMed

Naik, Ganesh R; Kumar, Dinesh K; Yadav, Vivek; Wheeler, Katherine; Arjunan, Sridhar

2009-01-01

Spectral compression of surface electromyogram (sEMG) is associated with onset of localized muscle fatigue. The spectral compression has been explained based on motor unit synchronization theory. According to this theory, motor units are pseudo randomly excited during muscle contraction, and with the onset of muscle fatigue the recruitment pattern changes such that motor unit firings become more synchronized. While this is widely accepted, there is little experimental proof of this phenomenon. This paper has used source dependence measures developed in research related to independent component analysis (ICA) to test this theory.

21 CFR 312.52 - Transfer of obligations to a contract research organization.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Transfer of obligations to a contract research organization. 312.52 Section 312.52 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN... and Investigators § 312.52 Transfer of obligations to a contract research organization. (a) A sponsor...

Military Personnel Procurement Resources Report

DTIC Science & Technology

1991-05-28

directed at enlistment in the Military Service. Include cost of advertising agency contract spent on marketing research (to include cost of advertising...programs. Include cost of advertising agency contract spent on marketing research (to include cost of advertising agency subcontractors). 7. Printed...Include cost of advertising agency contract spent on marketing research (to include cost of advertising agency sub- contractors). 7. Printed

Policy Development for Research Grants, and Contracts Administration in the Small College or University.

ERIC Educational Resources Information Center

Lyons, Paul R.

Some of the major administrative factors that will require attention by small colleges and universities as they develop policy and general procedures for the administration of research, grants, and contracts are considered. Management of research, grants, and contracts is a process that involves the review and approval of proposals; project…

13 CFR 124.503 - How does SBA accept a procurement for award through the 8(a) BD program?

Code of Federal Regulations, 2011 CFR

2011-01-01

... market research, the contracting officer shall first consider a set-aside or sole source award (if the... market research conducted. In addition, the contracting officer must document the contract file showing... factors such as the results of market research, programmatic needs specific to the procuring agency...

Uniformed Services Worldwide Legal Assistance & Reserve Components Office Directory. Revised.

DTIC Science & Technology

1999-11-01

Number: 256-876-9438 E-mail: ihermin@redstone-emhl.army.mil j ohn .henningsen@redstone. army.mil Practice Area: 600 Public Contract Law Bars...mail Address: thompsonia@cbcph.navy.mil Practice Area: 600 - Public Contract Law ; 451 - Government-Federal Level; 365 - Environmental Law Bars...Employment Law; 600 - Public Contract Law Bars Admitted: DC, IL County of Practice: Prince George’s, MD 22 AIR FORCE 89 AW/JA 1535 Command Drive

Parasympathetic neural control of canine tracheal smooth muscle.

PubMed

Kobayashi, Ichiro; Kondo, Tetsuri; Hayama, Naoki; Tazaki, Gen

2004-12-01

The middle segment of the trachea is innervated by the recurrent laryngeal and pararecurrent nerves. This study determined the pathway that mediated descending commands to the tracheal smooth muscle. Animals used were seven paralyzed and tracheostomized dogs. Tracheal contraction induced either by apnea, mechanical stimulation of the tracheal bifurcation or hypercapnia was always composed of tonic and rhythmic components. The rhythmic contraction developed in synchrony with rhythmic bursts on phrenic nerve activity (PNA). The respiratory-related bursts were also observed on the recurrent laryngeal nerve activity (RNA) and pararecurrent nerve activity (ParaRNA). During apnea there was no tonic activity neither on RNA or PNA, whereas ParaRNA had both tonic and rhythmic activities. Bursts on RNA preceded to correspondent PNA-bursts by 90+/-13 ms. In contrast, ParaRNA-burst always developed later than PNA-burst and it started at almost the same time as that of tracheal rhythmic contraction. During mechanical stimulation of the trachea or CO2-loading, though RNA did not include tonic component, ParaRNA had tonic activity during tracheal tonic contraction. These findings suggested that rhythmic and tonic contractions of the trachea were mediated through the pararecurrent nerve but not through the recurrent laryngeal nerve.

Muscle contraction phenotypic analysis enabled by optogenetics reveals functional relationships of sarcomere components in Caenorhabditis elegans.

PubMed

Hwang, Hyundoo; Barnes, Dawn E; Matsunaga, Yohei; Benian, Guy M; Ono, Shoichiro; Lu, Hang

2016-01-29

The sarcomere, the fundamental unit of muscle contraction, is a highly-ordered complex of hundreds of proteins. Despite decades of genetics work, the functional relationships and the roles of those sarcomeric proteins in animal behaviors remain unclear. In this paper, we demonstrate that optogenetic activation of the motor neurons that induce muscle contraction can facilitate quantitative studies of muscle kinetics in C. elegans. To increase the throughput of the study, we trapped multiple worms in parallel in a microfluidic device and illuminated for photoactivation of channelrhodopsin-2 to induce contractions in body wall muscles. Using image processing, the change in body size was quantified over time. A total of five parameters including rate constants for contraction and relaxation were extracted from the optogenetic assay as descriptors of sarcomere functions. To potentially relate the genes encoding the sarcomeric proteins functionally, a hierarchical clustering analysis was conducted on the basis of those parameters. Because it assesses physiological output different from conventional assays, this method provides a complement to the phenotypic analysis of C. elegans muscle mutants currently performed in many labs; the clusters may provide new insights and drive new hypotheses for functional relationships among the many sarcomere components.

Muscle contraction phenotypic analysis enabled by optogenetics reveals functional relationships of sarcomere components in Caenorhabditis elegans

NASA Astrophysics Data System (ADS)

Hwang, Hyundoo; Barnes, Dawn E.; Matsunaga, Yohei; Benian, Guy M.; Ono, Shoichiro; Lu, Hang

2016-01-01

The sarcomere, the fundamental unit of muscle contraction, is a highly-ordered complex of hundreds of proteins. Despite decades of genetics work, the functional relationships and the roles of those sarcomeric proteins in animal behaviors remain unclear. In this paper, we demonstrate that optogenetic activation of the motor neurons that induce muscle contraction can facilitate quantitative studies of muscle kinetics in C. elegans. To increase the throughput of the study, we trapped multiple worms in parallel in a microfluidic device and illuminated for photoactivation of channelrhodopsin-2 to induce contractions in body wall muscles. Using image processing, the change in body size was quantified over time. A total of five parameters including rate constants for contraction and relaxation were extracted from the optogenetic assay as descriptors of sarcomere functions. To potentially relate the genes encoding the sarcomeric proteins functionally, a hierarchical clustering analysis was conducted on the basis of those parameters. Because it assesses physiological output different from conventional assays, this method provides a complement to the phenotypic analysis of C. elegans muscle mutants currently performed in many labs; the clusters may provide new insights and drive new hypotheses for functional relationships among the many sarcomere components.

Fibrinogen inhibits fibroblast-mediated contraction of collagen

PubMed Central

Nien, Yih-Dar; Han, Yuan-Ping; Tawil, Bill; Chan, Linda S.; Tuan, Tai-Lan; Garner, Warren L.

2008-01-01

Extracellular matrix changes in composition and organization as it transitions from the provisional matrix of the fibrin/platelet plug to collagen scar in healed wounds. The manner in which individual matrix proteins affect these activities is not well established. In this article we describe the interactions of two important extracellular matrix components, fibrin and collagen, using an in vitro model of wound contraction, the fibroblast-populated collagen lattice. We utilized different fibrinogen sources and measured tissue reorganization in floating and tensioned collagen lattices. Our results showed that both fibrin and fibrinogen decreased the contraction of fibroblast populated collagen lattices in a dose-dependent manner. Polymerization of fibrinogen to fibrin using thrombin had no effect on this inhibition. Further, there was no effect due to changes in protein concentration, alternate components of the fibrin sealant, or the enzymatic action of thrombin. These results suggest that the initial stability of the fibrin provisional matrix is due to the fibrin, because this protein appears to inhibit contraction of the matrix. This may be important in the early phases of wound healing when clot stability is vital for hemostasis. Later, as fibrin is replaced by collagen, wound contraction can occur. PMID:12950643

48 CFR 237.104 - Personal services contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... procedures do not apply to contracts awarded to business entities other than individuals. Selections made... intelligence component or counter-intelligence organization of DoD; or (iii) Directly support the mission of... travel between home or place of business and official duty station. (iii) Coordinate with the civilian...

48 CFR 211.274-6 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Contract clauses. 211.274-6 Section 211.274-6 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... with 211.274-2(a)(4) for DoD serially managed subassemblies, components, or parts embedded within...

48 CFR 211.274-6 - Contract clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Contract clauses. 211.274-6 Section 211.274-6 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... with 211.274-2(a)(4) for DoD serially managed subassemblies, components, or parts embedded within...

48 CFR 235.001 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.001 Definitions. “Research and development” means those efforts described by the Research, Development, Test, and Evaluation...

Bidirectional regulation of human colonic smooth muscle contractility by tachykinin NK(2) receptors.

PubMed

Nakamura, Akihiro; Tanaka, Takahiro; Imanishi, Akio; Kawamoto, Makiko; Toyoda, Masao; Mizojiri, Gaku; Tsukimi, Yasuhiro

2011-01-01

In this study, we attempted to clarify the mechanism of tachykinin-induced motor response in isolated smooth muscle preparations of the human colon. Fresh specimens of normal colon were obtained from patients suffering from colonic cancer. Using mucosa-free smooth muscle strips, smooth muscle tension with circular direction was monitored isometrically. Substance P (SP), neurokinin A (NKA), and neurokinin B (NKB) produced marked contraction. All of these contractions were inhibited by saredutant, a selective NK(2)-R antagonist, but not by CP122721, a selective NK(1)-R antagonist or talnetant, a selective NK(3)-R antagonist. βAla(8)-NKA(4-10) induced concentration-dependent contraction similar to NKA, but Sar(9)-Met(11)-SP and Met-Phe(7)-NKB did not cause marked contraction. Colonic contraction induced by βAla(8)-NKA(4-10) was completely blocked by saredutant, but not by atropine. Tetrodotoxin or N(G)-nitro-L-arginine methyl ester pretreatment significantly enhanced βAla(8)-NKA(4-10)-induced contraction. Immunohistochemical analysis showed that the NK(2)-R was expressed on the smooth muscle layers and myenteric plexus where it was also co-expressed with neuronal nitric oxide synthase in the myenteric plexus. These results suggest that the NK(2)-R is a major contributor to tachykinin-induced smooth muscle contraction in human colon and that the NK(2)-R-mediated response consists of an excitatory component via direct action on the smooth muscle and an inhibitory component possibly via nitric oxide neurons.

17 CFR Appendix C - Demonstration of Compliance That a Contract Is Not Readily Susceptible to Manipulation

Code of Federal Regulations, 2014 CFR

2014-04-01

... contract market. When designing a futures contract, the designated contract market should conduct market research so that the contract design meets the risk management needs of prospective users and promotes... users to obtain their views and opinions during the contract design process to ensure the contract's...

NASA's Exploration Technology Development Program Energy Storage Project Battery Technology Development

NASA Technical Reports Server (NTRS)

Reid, Concha M.; Miller, Thomas B.; Mercer, Carolyn R.; Jankovsky, Amy L.

2010-01-01

Technical Interchange Meeting was held at Saft America s Research and Development facility in Cockeysville, Maryland on Sept 28th-29th, 2010. The meeting was attended by Saft, contractors who are developing battery component materials under contracts awarded through a NASA Research Announcement (NRA), and NASA. This briefing presents an overview of the components being developed by the contractor attendees for the NASA s High Energy (HE) and Ultra High Energy (UHE) cells. The transition of the advanced lithium-ion cell development project at NASA from the Exploration Technology Development Program Energy Storage Project to the Enabling Technology Development and Demonstration High Efficiency Space Power Systems Project, changes to deliverable hardware and schedule due to a reduced budget, and our roadmap to develop cells and provide periodic off-ramps for cell technology for demonstrations are discussed. This meeting gave the materials and cell developers the opportunity to discuss the intricacies of their materials and determine strategies to address any particulars of the technology.

48 CFR 935.070 - Research misconduct.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Research misconduct. 935... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 935.070 Research misconduct. (a) Applicability. The DOE research misconduct policy set forth at 10 CFR part 733 addresses research misconduct by individuals who...

48 CFR 935.070 - Research misconduct.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Research misconduct. 935... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 935.070 Research misconduct. (a) Applicability. The DOE research misconduct policy set forth at 10 CFR part 733 addresses research misconduct by individuals who...

48 CFR 935.070 - Research misconduct.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Research misconduct. 935... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 935.070 Research misconduct. (a) Applicability. The DOE research misconduct policy set forth at 10 CFR part 733 addresses research misconduct by individuals who...

48 CFR 935.070 - Research misconduct.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Research misconduct. 935... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 935.070 Research misconduct. (a) Applicability. The DOE research misconduct policy set forth at 10 CFR part 733 addresses research misconduct by individuals who...

48 CFR 935.070 - Research misconduct.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Research misconduct. 935... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 935.070 Research misconduct. (a) Applicability. The DOE research misconduct policy set forth at 10 CFR part 733 addresses research misconduct by individuals who...

Generation of poleward moving auroral forms (PMAFs) during periods of dayside auroral oval expansions/contractions and periods when the dayside auroral oval is expanded and stable

NASA Astrophysics Data System (ADS)

Fasel, G. J.; Flicker, J.; Sibeck, D. G.; Alyami, M.; Angelo, A.; Aylward, R. J.; Bender, S.; Christensen, M.; Kim, J.; Kristensen, H.; Orellana, Y.; Sahin, O.; Yoon, J.; Green, D.; Sigernes, F.; Lorentzen, D. A.

2013-12-01

The latitude of the equatorial edge of the dayside auroral oval has been shown to vary with the direction of the IMF Bz-component. The equatorward/poleward edge of the dayside auroral oval shifts equatorward/poleward when the IMF Bz-component is negative/positive [Burch, 1973; Akasofu, 1977; Horwitz and Akasofu, 1977; Sandholt et al., 1986, 1988]. Past studies have shown that poleward-moving auroral forms (PMAFs) are a common feature during equatorward expansions of the dayside auroral oval. Horwitz and Akasofu [1977] noted a one-to-one correspondence of luminous PMAFs associated with an equatorward expansion of the dayside auroral oval. During the southward turning of the IMF Bz-component the merging rate on the dayside increases [Newell and Meng, 1987] leading to the erosion of the dayside magnetopause. The field line merging process is thought to be most efficient when the interplanetary magnetic field (IMF) Bz-component turns southward. Both Vorobjev et al. [1975] and Horwitz and Akasofu [1977] attributed these PMAFs to magnetic flux being eroded away from the dayside magnetopause and transported antisunward. Dayside poleward-moving auroral forms are also observed during periods of an expanded and stable dayside auroral oval for both northern and southern hemisphere observations [Sandholt et al., 1986, 1989, 1990; Rairden and Mende, 1989; Mende et al., 1990]. Poleward-moving auroral forms have also been observed during some dayside oval contractions but have not been discussed much in the literature. This study examines the dayside auroral oval during periods of expansion, contraction, and during periods of an expanded and stable dayside auroral oval. This statistical study will provide the following results: number of poleward-moving auroral forms that are generated during dayside auroral oval expansions/contractions and during periods of a stable and expanded dayside auroral oval, the average initial and final elevation angle of the dayside auroral oval, time for dayside auroral oval to expand or contract, and the solar wind parameters (IMF Bx, By, Bz, speed, and pressure) associated with each interval (expansion, contraction, or stable and expanded).

48 CFR 32.403 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., research, or development work with nonprofit educational or research institutions. (b) Contracts solely for... could not be expected to suitably administer a guaranteed loan. (g) Contracts with small business... contract financing method for both the Government and the contractor. [48 FR 42328, Sept. 19, 1983, as...

48 CFR 917.7300 - Scope of subpart.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Section 917.7300 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Program Research and Development Announcements 917.7300 Scope of subpart. (a) This subpart discusses the policy for the use of a program research and development...

48 CFR 731.773 - Independent research and development costs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Independent research and development costs. 731.773 Section 731.773 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Nonprofit...

48 CFR 731.773 - Independent research and development costs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Independent research and development costs. 731.773 Section 731.773 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL CONTRACTING REQUIREMENTS CONTRACT COST PRINCIPLES AND PROCEDURES Contracts With Nonprofit...

Optimal Selection of Time Series Coefficients for Wrist Myoelectric Control Based on Intramuscular Recordings

DTIC Science & Technology

2001-10-25

considered static or invariant because the spectral behavior of EMG data is dependent on the specific muscle , contraction level, and limb function. However...produced at the onset of the muscle contraction . Because the units with lower conduction velocity (lower frequency components) are recruited first, the

Effective Components of Contingency Contracts with Academic Behaviors of College Students

ERIC Educational Resources Information Center

McCoy, James F.; And Others

1977-01-01

Investigates the comparative effects of written as opposed to verbally stated instructions and specification of contingencies, with the written contract containing the typically used written agreement. These procedures were applied to self-managed, naturalistic behaviors, and compared to self-monitoring alone. Study-question answering and amount…

A Graphical Approach to the Standard Principal-Agent Model.

ERIC Educational Resources Information Center

Zhou, Xianming

2002-01-01

States the principal-agent theory is difficult to teach because of its technical complexity and intractability. Indicates the equilibrium in the contract space is defined by the incentive parameter and insurance component of pay under a linear contract. Describes a graphical approach that students with basic knowledge of algebra and…

Fluctuations in isometric muscle force can be described by one linear projection of low-frequency components of motor unit discharge rates

PubMed Central

Negro, Francesco; Holobar, Aleš; Farina, Dario

2009-01-01

The aim of the study was to investigate the relation between linear transformations of motor unit discharge rates and muscle force. Intramuscular (wire electrodes) and high-density surface EMG (13 × 5 electrode grid) were recorded from the abductor digiti minimi muscle of eight healthy men during 60 s contractions at 5%, 7.5% and 10% of the maximal force. Spike trains of a total of 222 motor units were identified from the EMG recordings with decomposition algorithms. Principal component analysis of the smoothed motor unit discharge rates indicated that one component (first common component, FCC) described 44.2 ± 7.5% of the total variability of the smoothed discharge rates when computed over the entire contraction interval and 64.3 ± 10.2% of the variability when computed over 5 s intervals. When the FCC was computed from four or more motor units per contraction, it correlated with the force produced by the muscle (62.7 ± 10.1%) by a greater degree (P < 0.001) than the smoothed discharge rates of individual motor units (41.4 ± 7.8%). The correlation between FCC and the force signal increased up to 71.8 ± 13.1% when the duration and the shape of the smoothing window for discharge rates were similar to the average motor unit twitch force. Moreover, the coefficients of variation (CoV) for the force and for the FCC signal were correlated in all subjects (R2 range = 0.14–0.56; P < 0.05) whereas the CoV for force was correlated to the interspike interval variability in only one subject (R2= 0.12; P < 0.05). Similar results were further obtained from measures on the tibialis anterior muscle of an additional eight subjects during contractions at forces up to 20% of the maximal force (e.g. FCC explained 59.8 ± 11.0% of variability of the smoothed discharge rates). In conclusion, one signal captures most of the underlying variability of the low-frequency components of motor unit discharge rates and explains large part of the fluctuations in the motor output during isometric contractions. PMID:19840996

Fluctuations in isometric muscle force can be described by one linear projection of low-frequency components of motor unit discharge rates.

PubMed

Negro, Francesco; Holobar, Ales; Farina, Dario

2009-12-15

The aim of the study was to investigate the relation between linear transformations of motor unit discharge rates and muscle force. Intramuscular (wire electrodes) and high-density surface EMG (13 x 5 electrode grid) were recorded from the abductor digiti minimi muscle of eight healthy men during 60 s contractions at 5%, 7.5% and 10% of the maximal force. Spike trains of a total of 222 motor units were identified from the EMG recordings with decomposition algorithms. Principal component analysis of the smoothed motor unit discharge rates indicated that one component (first common component, FCC) described 44.2 +/- 7.5% of the total variability of the smoothed discharge rates when computed over the entire contraction interval and 64.3 +/- 10.2% of the variability when computed over 5 s intervals. When the FCC was computed from four or more motor units per contraction, it correlated with the force produced by the muscle (62.7 +/- 10.1%) by a greater degree (P < 0.001) than the smoothed discharge rates of individual motor units (41.4 +/- 7.8%). The correlation between FCC and the force signal increased up to 71.8 +/- 13.1% when the duration and the shape of the smoothing window for discharge rates were similar to the average motor unit twitch force. Moreover, the coefficients of variation (CoV) for the force and for the FCC signal were correlated in all subjects (R(2) range = 0.14-0.56; P < 0.05) whereas the CoV for force was correlated to the interspike interval variability in only one subject (R(2) = 0.12; P < 0.05). Similar results were further obtained from measures on the tibialis anterior muscle of an additional eight subjects during contractions at forces up to 20% of the maximal force (e.g. FCC explained 59.8 +/- 11.0% of variability of the smoothed discharge rates). In conclusion, one signal captures most of the underlying variability of the low-frequency components of motor unit discharge rates and explains large part of the fluctuations in the motor output during isometric contractions.

42 CFR 67.103 - Peer review of contract proposals.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 67.103 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING AGENCY FOR HEALTH CARE POLICY AND RESEARCH GRANTS AND CONTRACTS Peer Review of Contracts for Health Services Research, Evaluation, Demonstration, and Dissemination Projects § 67.103 Peer...

75 FR 10567 - Commerce Acquisition Regulation (CAR)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-08

... acquisitions, contract financing, protests, disputes, and appeals, major system acquisitions, research and... appeals. SUBCHAPTER F--SPECIAL CATEGORIES OF CONTRACTING 1334 Major system acquisition. 1335 Research and....603-2, selection of contracting officers shall be based upon Section 4 of CAM 1301.6. 1301.603-3...

48 CFR 1435.010 - Scientific and technical reports.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1435.010 Scientific and technical reports. If a Research and Development (R&D) contract results involve classified or national security... available. Copies of publications and reports are also required to be sent to the DOI Departmental Library...

48 CFR 1435.010 - Scientific and technical reports.

Code of Federal Regulations, 2013 CFR

2013-10-01

... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1435.010 Scientific and technical reports. If a Research and Development (R&D) contract results involve classified or national security... available. Copies of publications and reports are also required to be sent to the DOI Departmental Library...

48 CFR 1435.010 - Scientific and technical reports.

Code of Federal Regulations, 2011 CFR

2011-10-01

... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1435.010 Scientific and technical reports. If a Research and Development (R&D) contract results involve classified or national security... available. Copies of publications and reports are also required to be sent to the DOI Departmental Library...

48 CFR 1435.010 - Scientific and technical reports.

Code of Federal Regulations, 2012 CFR

2012-10-01

... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1435.010 Scientific and technical reports. If a Research and Development (R&D) contract results involve classified or national security... available. Copies of publications and reports are also required to be sent to the DOI Departmental Library...

48 CFR 1435.010 - Scientific and technical reports.

Code of Federal Regulations, 2014 CFR

2014-10-01

... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1435.010 Scientific and technical reports. If a Research and Development (R&D) contract results involve classified or national security... available. Copies of publications and reports are also required to be sent to the DOI Departmental Library...

Interpretation of 2-probe turbulence measurements in an axisymmetric contraction

NASA Technical Reports Server (NTRS)

Marion-Moulin, C.; Tan-Atichat, J.; Nagib, H. M.

1983-01-01

Simultaneous measurements of the streamwise and radial velocity components at two points, one on and one off the centerline with variable radial separation, were digitally recorded and processed at several stations along a four to one contraction with controlled upstream turbulence conditions. Various statistical quantities are presented including spectra and coherence functions. The integral L sub ux, L sub um, L sub vx, L sub vm were also estimated and their variation along the contraction is examined.

Effects of Bidens pilosa L. var. radiata SCHERFF treated with enzyme on histamine-induced contraction of guinea pig ileum and on histamine release from mast cells.

PubMed

Matsumoto, Takayuki; Horiuchi, Masako; Kamata, Katsuo; Seyama, Yoshiyuki

2009-06-01

The medical mechanism against type I allergies is to block the release or production of chemical mediators from mast cells or to block the H(1)-receptor signaling. We previously reported that the anti-allergic action of the dry powder from Bidens pilosa L. var. radiata SCHERFF treated with the enzyme cellulosine (eMMBP) was dependent on the inhibition of histamine release from mast cells. Here, we investigate that the effect of fractions in eMMBP on the histamine-induced contraction in guinea pig ileum and on the release of histamine in rat peritoneal mast cells. The histamine-induced contraction in guinea pig ileum is dose-dependently inhibited by ketotifen, an antagonist of H(1)-receptor. Fractions contained caffeic acid, caffeoylquinic acid and fractions contained flavonoids such as hyperin and isoquercitrin in eMMBP inhibit histamine release from mast cells, but only flavonoids such as hyperin, isoquercitrin and rutin suppress the histamine-induced contraction in guinea pig ileum. Moreover, the histamine-induced contraction was not affected by caffeic acid, however, such contraction was significantly inhibited by rutin. These results suggest that the primary antagonists of H(1)- receptor are different from the components in eMMBP that inhibit histamine release, and that these components participate in the anti-allergic activity of eMMBP.

48 CFR 1335.017 - Federal funded research and development centers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.017 Federal funded research and development centers. ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Federal funded research...

Evaluation of contract time estimation and contracting procedures : technical summary.

DOT National Transportation Integrated Search

1996-08-01

The objective of this research was 1) to provide the DOTD with a systematic approach to the determination of contract duration, and 2) to explore innovative contracting procedures that may prove beneficial in DOTD projects. The innovative contracting...

48 CFR 970.5235-1 - Federally funded research and development center sponsoring agreement.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Solicitation Provisions and Contract Clauses for Management and Operating Contracts 970.5235-1... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Federally funded research...

48 CFR 227.7204 - Contracts under the Small Business Innovative Research Program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Business Innovative Research Program. 227.7204 Section 227.7204 Federal Acquisition Regulations System... under the Small Business Innovative Research Program. When contracting under the Small Business Innovative Research Program, follow the procedures at 227-7104. ...

48 CFR 43.205 - Contract clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

...-engineer or other professional services, and no supplies are to be furnished, the contracting officer shall...-engineer or other professional services, the contracting officer shall use the clause with its Alternate... Accounting, in solicitations and contracts for supply and research and development contracts of significant...

48 CFR 43.205 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

...-engineer or other professional services, and no supplies are to be furnished, the contracting officer shall...-engineer or other professional services, the contracting officer shall use the clause with its Alternate... Accounting, in solicitations and contracts for supply and research and development contracts of significant...

48 CFR 43.205 - Contract clauses.

Code of Federal Regulations, 2013 CFR

2013-10-01

...-engineer or other professional services, and no supplies are to be furnished, the contracting officer shall...-engineer or other professional services, the contracting officer shall use the clause with its Alternate... Accounting, in solicitations and contracts for supply and research and development contracts of significant...

48 CFR 43.205 - Contract clauses.

Code of Federal Regulations, 2014 CFR

2014-10-01

...-engineer or other professional services, and no supplies are to be furnished, the contracting officer shall...-engineer or other professional services, the contracting officer shall use the clause with its Alternate... Accounting, in solicitations and contracts for supply and research and development contracts of significant...

48 CFR 43.205 - Contract clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

...-engineer or other professional services, and no supplies are to be furnished, the contracting officer shall...-engineer or other professional services, the contracting officer shall use the clause with its Alternate... Accounting, in solicitations and contracts for supply and research and development contracts of significant...

48 CFR 1535.007-70 - Contract clauses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Contract clauses. 1535.007-70 Section 1535.007-70 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1535.007-70 Contract clauses. The following...

48 CFR 1535.007-70 - Contract clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Contract clauses. 1535.007-70 Section 1535.007-70 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1535.007-70 Contract clauses. The following...

48 CFR 1535.007-70 - Contract clauses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Contract clauses. 1535.007-70 Section 1535.007-70 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1535.007-70 Contract clauses. The following...

48 CFR 1535.007-70 - Contract clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Contract clauses. 1535.007-70 Section 1535.007-70 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1535.007-70 Contract clauses. The following...

48 CFR 45.107 - Contract clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Alternate II when a contract for the conduct of basic or applied research at nonprofit institutions of higher education or at nonprofit organizations whose primary purpose is the conduct of scientific research (see 35.014) is contemplated. (b) The contracting officer shall also insert the clause at 52.245-2...

32 CFR 736.2 - Dispositions under contracts.

Code of Federal Regulations, 2010 CFR

2010-07-01

... contract terms and conditions. (c) Transfer to nonprofit education or research institutions of title to equipment purchased with funds available for grants or contracts for the conduct of basic or applied research is authorized by the act of September 6, 1958 (sec. 2, 72 Stat. 1793; 42 U.S.C. 1892) and...

48 CFR 435.010 - Scientific and technical reports.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Scientific and technical reports. 435.010 Section 435.010 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 435.010 Scientific and technical reports. Research and development contracts shal...

48 CFR 435.010 - Scientific and technical reports.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Scientific and technical reports. 435.010 Section 435.010 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 435.010 Scientific and technical reports. Research and development contracts shal...

48 CFR 435.010 - Scientific and technical reports.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Scientific and technical reports. 435.010 Section 435.010 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 435.010 Scientific and technical reports. Research and development contracts shal...

48 CFR 435.010 - Scientific and technical reports.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Scientific and technical reports. 435.010 Section 435.010 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 435.010 Scientific and technical reports. Research and development contracts shal...

New Perils for the Contract Ethnographer.

ERIC Educational Resources Information Center

Fetterman, David M.

1981-01-01

Conditions of contract research may lead some workers to ignore publication rights of colleagues whose reports are of limited circulation. The author presents a case example of how this process occurred with the use of his own work and argues for rigorous ethical standards in the publication of contract research results. (Author/GC)

Can conditional health policies be justified? A policy analysis of the new NHS dental contract reforms.

PubMed

Laverty, Louise; Harris, Rebecca

2018-06-01

Conditional policies, which emphasise personal responsibility, are becoming increasingly common in healthcare. Although used widely internationally, they are relatively new within the UK health system where there have been concerns about whether they can be justified. New NHS dental contracts include the introduction of a conditional component that restricts certain patients from accessing a full range of treatment until they have complied with preventative action. A policy analysis of published documents on the NHS dental contract reforms from 2009 to 2016 was conducted to consider how conditionality is justified and whether its execution is likely to cause distributional effects. Contractualist, paternalistic and mutualist arguments that reflect notions of responsibility and obligation are used as justification within policy. Underlying these arguments is an emphasis on preserving the finite resources of a strained NHS. We argue that the proposed conditional component may differentially affect disadvantaged patients, who do not necessarily have access to the resources needed to meet the behavioural requirements. As such, the conditional component of the NHS dental contract reform has the potential to exacerbate oral health inequalities. Conditional health policies may challenge core NHS principles and, as is the case with any conditional policy, should be carefully considered to ensure they do not exacerbate health inequities. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

41 CFR 102-85.40 - What are the major components of the pricing policy?

Code of Federal Regulations, 2010 CFR

2010-07-01

... components of the pricing policy? 102-85.40 Section 102-85.40 Public Contracts and Property Management...-PRICING POLICY FOR OCCUPANCY IN GSA SPACE Pricing Policy-General § 102-85.40 What are the major components of the pricing policy? The major components of the pricing policy are: (a) An OA between a customer...

The slow inward calcium current is responsible for a part of the contraction of patch-clamped rat myoballs.

PubMed

Rivet, M; Cognard, C; Raymond, G

1989-01-01

The slow inward calcium current and the contractile response were simultaneously recorded in voltage clamped (whole cell patch clamp recording) rat myoballs in primary culture. The shape of the contraction(T)/potential(V) relationship and the application of the inorganic calcium channel blocker cadmium (1.5 mM), which suppresses a part of the contractile activity, demonstrate the existence of two components of contraction. One of them is related to the slow calcium current.

Characterization of 8-cm engineering model thruster

NASA Technical Reports Server (NTRS)

Williamson, W. S.

1984-01-01

Development of 8 cm ion thruster technology which was conducted in support of the Ion Auxiliary Propulsion System (IAPS) flight contract (Contract NAS3-21055) is discussed. The work included characterization of thruster performance, stability, and control; a study of the effects of cathode aging; environmental qualification testing; and cyclic lifetesting of especially critical thruster components.

Augmentation of the Ascending Component of the Peristaltic Reflex and Substance P Release by Glial Cell Line-Derived Neurotrophic Factor (GDNF)

PubMed Central

Grider, JR; Heuckeroth, RO; Kuemmerle, JF; Murthy, KS

2010-01-01

Glial cell line derived neurotrophic factor (GDNF) is present in adult gut although its role in the mature enteric nervous system is not well defined. The aim of the present study was to examine the role of GDNF as neuromodulator of the ascending phase of the peristaltic reflex. Colonic segments were prepared as flat sheets and placed in compartmented chambers so as to separate the sensory and motor limbs of the reflex. Ascending contraction was measured in the orad compartment and mucosal stroking stimuli (2-8 strokes) were applied in the caudad compartment. GDNF and substance P release were measured and the effects of GDNF and GDNF antibody on contraction and release were determined. Mice with reduced levels of GDNF (Gdnf+/-) and wild type littermates were also examined. GDNF was released in a stimulus-dependent manner into the orad motor but not caudad sensory compartment. Addition of GDNF to the orad motor but not caudad sensory compartment augmented ascending contraction and substance P release. Conversely, addition of GDNF antibody to the orad motor but not caudad sensory compartment reduced ascending contraction and substance P release. Similarly, the ascending contraction and substance P release into the orad motor compartment was reduced in Gdnf+/- mice as compared to wild type littermates. The results suggest that endogenous GDNF is released during the ascending contraction component of the peristaltic reflex where it acts as a neuromodulator to augment substance P release from motor neurons thereby augmenting contraction of circular muscle orad to the site of stimulation. PMID:20331804

Endogenous gamma-aminobutyric acid modulates tonic guinea pig airway tone and propofol-induced airway smooth muscle relaxation.

PubMed

Gallos, George; Gleason, Neil R; Virag, Laszlo; Zhang, Yi; Mizuta, Kentaro; Whittington, Robert A; Emala, Charles W

2009-04-01

Emerging evidence indicates that an endogenous autocrine/paracrine system involving gamma-aminobutyric acid (GABA) is present in airways. GABAA channels, GABAB receptors, and the enzyme that synthesizes GABA have been identified in airway epithelium and smooth muscle. However, the endogenous ligand itself, GABA, has not been measured in airway tissues. The authors sought to demonstrate that GABA is released in response to contractile agonists and tonically contributes a prorelaxant component to contracted airway smooth muscle. The amount and cellular localization of GABA in upper guinea pig airways under resting and contracted tone was determined by high pressure liquid chromatography and immunohistochemistry, respectively. The contribution that endogenous GABA imparts on the maintenance of airway smooth muscle acetylcholine-induced contraction was assessed in intact guinea pig airway tracheal rings using selective GABAA antagonism (gabazine) under resting or acetylcholine-contracted conditions. The ability of an allosteric agent (propofol) to relax a substance P-induced relaxation in an endogenous GABA-dependent manner was assessed. GABA levels increased and localized to airway smooth muscle after contractile stimuli in guinea pig upper airways. Acetylcholine-contracted guinea pig tracheal rings exhibited an increase in contracted force upon addition of the GABAA antagonist gabazine that was subsequently reversed by the addition of the GABAA agonist muscimol. Propofol dose-dependently relaxed a substance P contraction that was blocked by gabazine. These studies demonstrate that GABA is endogenously present and increases after contractile stimuli in guinea pig upper airways and that endogenous GABA contributes a tonic prorelaxant component in the maintenance of airway smooth muscle tone.

Augmentation of the ascending component of the peristaltic reflex and substance P release by glial cell line-derived neurotrophic factor.

PubMed

Grider, J R; Heuckeroth, R O; Kuemmerle, J F; Murthy, K S

2010-07-01

Glial cell line-derived neurotrophic factor (GDNF) is present in adult gut although its role in the mature enteric nervous system is not well defined. The aim of the present study was to examine the role of GDNF as neuromodulator of the ascending phase of the peristaltic reflex. Colonic segments were prepared as flat sheets and placed in compartmented chambers so as to separate the sensory and motor limbs of the reflex. Ascending contraction was measured in the orad compartment and mucosal stroking stimuli (two to eight strokes) were applied in the caudad compartment. GDNF and substance P (SP) release were measured and the effects of GDNF and GDNF antibody on contraction and release were determined. Mice with reduced levels of GDNF (Gdnf(+/-)) and wild type littermates were also examined. GDNF was released in a stimulus-dependent manner into the orad motor but not caudad sensory compartment. Addition of GDNF to the orad motor but not caudad sensory compartment augmented ascending contraction and SP release. Conversely, addition of GDNF antibody to the orad motor but not caudad sensory compartment reduced ascending contraction and SP release. Similarly, the ascending contraction and SP release into the orad motor compartment was reduced in Gdnf(+/-) mice as compared to wild type littermates. The results suggest that endogenous GDNF is released during the ascending contraction component of the peristaltic reflex where it acts as a neuromodulator to augment SP release from motor neurons thereby augmenting contraction of circular muscle orad to the site of stimulation.

Scout

NASA Image and Video Library

1960-09-22

Photographed on 09/22/1960. -- An examination of the Aerojet-General "Aerobee 150A" propulsion system in February 1960. James Hansen described this as follows: "As for the technical definition of the rocket...the Langley engineers tried to keep developmental costs and time to a minimum by selecting components from off-the-shelf hardware. the majority of Scout's components were to come from an inventory of solid-fuel rockets produced for the military, although everyone involved understood that some improved motors would also have to be developed under contract. By early 1959, after intensive technical analysis and reviews, Langley settled on a design and finalized the selection of the major contractors. The rocket's 40-inch-diameter first stage was to be a new "Algol" motor, a combination of the Jupiter Senior and the navy Polaris produced by the Aerojet General Corporation, Sacramento, California. The 31-inch-diameter second stage, "Castor," was derived from the army's Sergeant and was to be manufactured by the Redstone Division of the Thiokol company in Huntsville, Alabama. the motor for the 30-inch-diameter third stage, "Antares," evolved under NASA contract from the ABL X248 design into a new version called the X254 (and subsequently into the X259); it was built under contract to NASA by ABL, a U.S. Navy Bureau of Ordnance facility operated by the Hercules Powder Company, Cumberland, Maryland. the final upper-stage propulsion unit, "Altair," which was 25.7 inches in diameter (34 inches at the heat shield), amounted to an improved edition of the X248 that was also manufactured by ABL." -- Published in James R. Hansen, Spaceflight Revolution: NASA Langley Research Center From Sputnik to Apollo, NASA SP-4308, pp.200-201.

48 CFR 1835.016-71 - NASA Research Announcements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true NASA Research Announcements... ADMINISTRATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1835.016-71 NASA Research Announcements. (a) Scope. An NRA is used to announce research interests in support of NASA's programs, and...

Gas Analyzer

NASA Technical Reports Server (NTRS)

1989-01-01

The M200 originated in the 1970's under an Ames Research Center/Stanford University contract to develop a small, lightweight gas analyzer for Viking Landers. Although the unit was not used on the spacecraft, it was further developed by The National Institute for Occupational Safety and Health (NIOSH). Three researchers from the project later formed Microsensor Technology, Inc. (MTI) to commercialize the analyzer. The original version (Micromonitor 500) was introduced in 1982, and the M200 in 1988. The M200, a more advanced version, features dual gas chromatograph which separate a gaseous mixture into components and measure concentrations of each gas. It is useful for monitoring gas leaks, chemical spills, etc. Many analyses are completed in less than 30 seconds, and a wide range of mixtures can be analyzed.

NDI method for quantification of weak bonding strength of composite structures. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Johnson, R.F.

This Phase 1 Final Report is for a Small Business Innovation Research program conducted for the Navy under Federal Contract N00189-96-M-JT09. The purpose was to investigate ways to determine the overall strength of a composite structure by using a nondestructive evaluative (NDE) optical technique, shearography. The purpose of the research was to determine if there is an effective way to assess the strength of composite components on in-service aircraft rather than in the front end of the composite manufacturing process. The goal was to determine the overall feasibility of such an NDE method, and to investigate various means of probingmore » the material under test.« less

17 CFR 38.1201 - Additional sources for compliance.

Code of Federal Regulations, 2014 CFR

2014-04-01

... designing a futures contract, the designated contract market should conduct market research so that the contract design meets the risk management needs of prospective users and promotes price discovery of the... and opinions during the contract design process to ensure the contract's term and conditions reflect...

48 CFR 916.405-2 - Cost-plus-award-fee contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., output, be it hardware, research and development, demonstration or services, together with business... CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 916.405-2 Cost-plus-award-fee... appropriate) and business management considerations tailored to the needs of the particular situation. In...

48 CFR 35.006 - Contracting methods and contract type.

Code of Federal Regulations, 2011 CFR

2011-10-01

... indicated a high degree of probability that development is feasible and (2) the Government has determined... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.006 Contracting methods and..., performance objectives, and specifications for the work can be defined will largely determine the type of...

48 CFR 235.072 - Additional contract clauses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Additional contract clauses. 235.072 Section 235.072 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.072 Additional contract clauses. (a) Use the...

48 CFR 235.072 - Additional contract clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Additional contract clauses. 235.072 Section 235.072 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.072 Additional contract clauses. (a) Use the...

A Module Language for Typing by Contracts

NASA Technical Reports Server (NTRS)

Glouche, Yann; Talpin, Jean-Pierre; LeGuernic, Paul; Gautier, Thierry

2009-01-01

Assume-guarantee reasoning is a popular and expressive paradigm for modular and compositional specification of programs. It is becoming a fundamental concept in some computer-aided design tools for embedded system design. In this paper, we elaborate foundations for contract-based embedded system design by proposing a general-purpose module language based on a Boolean algebra allowing to define contracts. In this framework, contracts are used to negotiate the correctness of assumptions made on the definition of a component at the point where it is used and provides guarantees to its environment. We illustrate this presentation with the specification of a simplified 4-stroke engine model.

University Research and Development Activities: The Federal Income Tax Consequences of Research Contracts, Research Subsidiaries and Joint Ventures.

ERIC Educational Resources Information Center

Kertz, Consuelo Lauda; Hasson, James K., Jr.

1986-01-01

Features of the federal income tax law applying to income received from commercially funded university-based scientific research and development activities are discussed, including: industry-sponsored research contracts, separately incorporated entities, partnerships and joint ventures, subsidiaries and unrelated income consequences of…

48 CFR 235.015-70 - Special use allowances for research facilities acquired by educational institutions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... research facilities acquired by educational institutions. 235.015-70 Section 235.015-70 Federal Acquisition... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.015-70 Special use allowances for research facilities acquired by educational institutions. (a) Definitions. As used in this subsection— (1) Research facility...

48 CFR 32.202-3 - Conducting market research about financing terms.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Conducting market research... 32.202-3 Conducting market research about financing terms. Contract financing may be a subject included in the market research conducted in accordance with part 10. If market research for contract...

48 CFR 32.202-3 - Conducting market research about financing terms.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Conducting market research... 32.202-3 Conducting market research about financing terms. Contract financing may be a subject included in the market research conducted in accordance with part 10. If market research for contract...

48 CFR 3035.017 - Federally Funded Research and Development Centers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING Scope of Part 3035.017 Federally Funded Research and... use of Federally Funded Research and Development Centers (FFRDCs) in (FAR) 48 CFR 35.017. [71 FR 25771... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Federally Funded Research...

Assessment of Navy Contract Management Processes

DTIC Science & Technology

2016-02-22

Assessment of Navy Contract Management Processes 22 February 2016 Dr. Rene G. Rendon, Associate Professor Graduate School of Business ...Know) for each survey item in each contract management process area. Acquisition Research Program Graduate School of Business ...management process . Figure 1. U.S. Navy CMMM Maturity Levels Acquisition Research Program Graduate School of Business

13 CFR 126.607 - When must a contracting officer set aside a requirement for qualified HUBZone SBCs?

Code of Federal Regulations, 2012 CFR

2012-01-01

... fair market prices. This requirement does not preclude a contracting officer from setting aside a... will be made at fair market prices. However, after conducting market research, the contracting officer... to support the specific set-aside, including the type and extent of market research conducted. In...

Product Characteristics, Market Conditions and Contract Type: U.S. Department of Defense Use of Fixed-Price and Cost Reimbursement Contracts

DTIC Science & Technology

2015-07-27

R. (2013). Municipalities’ contracting out decisions: An empirical study on motives. Local Government Studies , 39(3), 414-434. Williamson, O...please contact any of the staff listed on the Acquisition Research Program website (www.acquisitionresearch.net). i Acquisition Research Program...market conditions on the use of fixed-price and cost reimbursement contracts by the Department of Defense. When the product is easy to specify

Orbit Transfer Rocket Engine Technology - 7.5K-LB Thrust Rocket Engine Preliminary Design

DTIC Science & Technology

1993-10-15

AND SPACE ADMINISTRATION October, 1993 r W NASA-Lewis Research Center Cleveland, Ohio 44135 94-08572 Contract Nc. NAS3-23773 Task B.7 and D.5 4I3’OA4 3 ...APPROACH 1 4.0 SUMMARY OF ACCOMPLISHMENTS 2 5.0 TECHNICAL DISCUSSIONS 3 6.0 PROGRAM WORK PLAN 5 6.1 Engine Analysis 5 6.2 Component Analysis 15 6.2.1...FIGURES Page Figure 1 Advanced Engine Studv Logic Diagram 4 Figure 2 Design Point Engine Pertormance at Full Thrust & MR = 6.0 7 Figure 3 Off-Design

Modeling Tools Predict Flow in Fluid Dynamics

NASA Technical Reports Server (NTRS)

2010-01-01

"Because rocket engines operate under extreme temperature and pressure, they present a unique challenge to designers who must test and simulate the technology. To this end, CRAFT Tech Inc., of Pipersville, Pennsylvania, won Small Business Innovation Research (SBIR) contracts from Marshall Space Flight Center to develop software to simulate cryogenic fluid flows and related phenomena. CRAFT Tech enhanced its CRUNCH CFD (computational fluid dynamics) software to simulate phenomena in various liquid propulsion components and systems. Today, both government and industry clients in the aerospace, utilities, and petrochemical industries use the software for analyzing existing systems as well as designing new ones."

48 CFR 1535.007 - Solicitations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1535.007 Solicitations. (a) Contracting officers... Confidential Business Information, in all solicitations when the contracting officer has determined that EPA may furnish the contractor with confidential business information which EPA had obtained from third...

48 CFR 17.601 - Definition.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 17.601 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Management and Operating Contracts 17.601 Definition. Management..., maintenance, or support, on its behalf, of a Government-owned or -controlled research, development, special...

Research led by participants: a new social contract for a new kind of research

PubMed Central

Vayena, Effy; Brownsword, Roger; Edwards, Sarah Jane; Greshake, Bastian; Kahn, Jeffrey P; Ladher, Navjoyt; O'Connor, Daniel; O'Neill, Onora; Richards, Martin P; Rid, Annette; Sheehan, Mark; Wicks, Paul; Tasioulas, John

2016-01-01

In recent years, there have been prominent calls for a new social contract that accords a more central role to citizens in health research. Typically, this has been understood as citizens and patients having a greater voice and role within the standard research enterprise. Beyond this, however, it is important that the renegotiated contract specifically addresses the oversight of a new, path-breaking approach to health research: participant-led research. In light of the momentum behind participant-led research and its potential to advance health knowledge by challenging and complementing traditional research, it is vital for all stakeholders to work together in securing the conditions that will enable it to flourish. PMID:25825527

A Female Urinary Diversion Device for Military Women in the Deployed Environment

DTIC Science & Technology

2016-10-27

9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) TriService Nursing Research TSNRP Program, 4301 Jones...reported there were many opportunities for a FUDD due to unsanitary and challenging conditions. Implications for Military Nursing : This research...Contract PoP: 6/1/2011 - 5/31/2016 Customer: TRISERVICE NURSING RESEARCH PROGRAM Customer Contract ID: HU0001 -11-1-TS02 Contract Manager: Robinson

48 CFR 1335.001 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.001 Definitions. Human subject means a living individual... includes communication or interpersonal contact between investigator and subject. “Private information...) in order for obtaining the information to constitute research involving human subjects. Research...

75 FR 990 - HHS Intent To Publish Grant and Contract Solicitations for Comparative Effectiveness Research...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-07

... Publish Grant and Contract Solicitations for Comparative Effectiveness Research (CER) Projects With Funds... input, the Comparative Effectiveness Research- Coordination Implementation Team, the Federal Coordinating Council for Comparative Effectiveness Research (FCC), and the Institute of Medicine Report on CER...

48 CFR 35.004 - Publicizing requirements and expanding research and development sources.

Code of Federal Regulations, 2011 CFR

2011-10-01

... and expanding research and development sources. 35.004 Section 35.004 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.004 Publicizing requirements and expanding research and development sources. (a) In order to...

48 CFR 35.009 - Subcontracting research and development effort.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.009 Subcontracting research and development effort. Since the selection of R&D contractors is substantially based on... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Subcontracting research...

Free-piston Stirling component test power converter

NASA Technical Reports Server (NTRS)

Dochat, George; Dhar, Manmohan

1991-01-01

The National Aeronautics and Space Administration (NASA) has been evaluating free-piston Stirling power converters (FPSPCs) for use on a wide variety of space missions. They provide high reliability, long life, and efficient operation and can be coupled with all potential heat sources, various heat input and heat rejection systems, and various power management and distribution systems. FPSPCs can compete favorably with alternative power conversion systems over a range of hundreds of watts to megawatts. Mechanical Technology Incorporated (MTI) is developing FPSPC technology under contract to NASA Lewis Research Center and will demonstrate this technology in two full-scale power converters operating at space temperature conditions. The testing of the first of these, the component test power converter (CTPC), was initiated in Spring 1991 to evaluate mechanical operation at space operating temperatures. The CTPC design, hardware fabrication, and initial test results are reviewed.

Mechanism of the calcium-regulation of muscle contraction--in pursuit of its structural basis.

PubMed

Wakabayashi, Takeyuki

2015-01-01

The author reviewed the research that led to establish the structural basis for the mechanism of the calcium-regulation of the contraction of striated muscles. The target of calcium ions is troponin on the thin filaments, of which the main component is the double-stranded helix of actin. A model of thin filament was generated by adding tropomyosin and troponin. During the process to provide the structural evidence for the model, the troponin arm was found to protrude from the calcium-depleted troponin and binds to the carboxyl-terminal region of actin. As a result, the carboxyl-terminal region of tropomyosin shifts and covers the myosin-binding sites of actin to block the binding of myosin. At higher calcium concentrations, the troponin arm changes its partner from actin to the main body of calcium-loaded troponin. Then, tropomyosin shifts back to the position near the grooves of actin double helix, and the myosin-binding sites of actin becomes available to myosin resulting in force generation through actin-myosin interactions.

Overview of NASA Lewis Research Center free-piston Stirling engine activities

NASA Technical Reports Server (NTRS)

Slaby, J. G.

1984-01-01

A generic free-piston Stirling technology project is being conducted to develop technologies generic to both space power and terrestrial heat pump applications in a cooperative, cost-shared effort. The generic technology effort includes extensive parametric testing of a 1 kW free-piston Stirling engine (RE-1000), development of a free-piston Stirling performance computer code, design and fabrication under contract of a hydraulic output modification for RE-1000 engine tests, and a 1000-hour endurance test, under contract, of a 3 kWe free-piston Stirling/alternator engine. A newly initiated space power technology feasibility demonstration effort addresses the capability of scaling a free-piston Stirling/alternator system to about 25 kWe; developing thermodynamic cycle efficiency or equal to 70 percent of Carnot at temperature ratios in the order of 1.5 to 2.0; achieving a power conversion unit specific weight of 6 kg/kWe; operating with noncontacting gas bearings; and dynamically balancing the system. Planned engine and component design and test efforts are described.

Combustion of two-component miscible droplets in reduced gravity

NASA Technical Reports Server (NTRS)

Shaw, Benjamin D.; Aharon, Israel; Gage, James W.; Jenkins, Andrew J.; Kahoe, Thomas J.

1995-01-01

This research focuses on the combustion of binary miscible droplets initially in the mm size range. Experiments are performed using the NASA Lewis 2.2 sec drop tower in Cleveland, Ohio, where mixtures of alkanes and/or alcohols are studied. The fuel components are selected to have significantly different volatilities. Initial oxygen mole fractions from about 0.15-0.5 and initial pressures from 0.2-2 atm are employed. Different inerts are used (He, CO2, Ar, N2) to change burning rates and sooting behaviors. Objectives are to observe the following: (1) Transient droplet diameters (including three-staged combustion behaviors and microexplosion; (2) Transient flow behaviors (sudden flame contraction, luminosity, extinction); and (3) Behaviors of observable soot particles. theoretical and computational research in support of this program has also been undertaken. This research includes analytical studies to determine the effects of small but nonzero gravitational levels on droplet gasification, analytical studies of hydrodynamic stability of spherically-symmetrical droplet gasification (to address the question as to whether spherically-symmetrical droplet gasification may be destabilized from capillary, i.e., Marangoni effects), and computational modeling of effects of capillary stresses on droplet gasification.

76 FR 59241 - Foreign Futures and Options Contracts on a Non-Narrow-Based Security Index; Commission...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-26

... controls on trading; information and data relating to the index, including the design, computation and... futures contract raises novel or complex issues that require additional time for review, or if the foreign... composition, computation, or method of selection of component entities of an index referenced and defined in...

SSC Test Operations Contract Overview

NASA Technical Reports Server (NTRS)

Kleim, Kerry D.

2010-01-01

This slide presentation reviews the Test Operations Contract at the Stennis Space Center (SSC). There are views of the test stands layouts, and closer views of the test stands. There are descriptions of the test stand capabilities, some of the other test complexes, the Cryogenic propellant storage facility, the High Pressure Industrial Water (HPIW) facility, and Fluid Component Processing Facility (FCPF).

Principles of Social Justice in Educational Research: The Case of Contract Research.

ERIC Educational Resources Information Center

Griffiths, Morwenna

1998-01-01

Delineates small-scale contract-research principles predicated on an understanding of social justice and of research purposes, epistemological issues, and possibilities for ethical and political action. Principles embrace improvement, knowledge and learning, changed belief systems, collaboration and consultation, openness to other communities,…

HIPAA Business Associate Contracts: the value of contracts for case managers.

PubMed

Muller, Lynn S

2003-01-01

Case Managers are in the middle of the upcoming HIPAA regulation changes, with the issuance of the Final Privacy Rule. Every case obliges case managers to work with Individually Identifiable Health Information (IIHI) and Protected Health Information (PHI). The purpose of this article is to provide case managers in all practice settings with a clear understanding of a "Business Associate," of a "Covered Entity," and of the specifics of a Business Associate Contract. This information will demonstrate how case managers can benefit from the use of these contracts in their business life. As an essential component of an organization's compliance plan, Business Associate Contracts can become a sword or a shield. This article is particularly helpful to case managers in independent practice, as well as those who work for Covered Entities.

Critical Life Prediction Research on Boron-Enhanced Ti-6A1-4V

DTIC Science & Technology

2007-05-01

2.4 High Modulus Ti-6Al-2Fe-0.1Si-0.6B “T” Extrusions for HSCT program. Ref. Government Contract No. NASI -20220: High Speed Research-Airframe...0.1Si-0.6B “T” Extrusions for HSCT program. Ref. Government Contract No. NASI -20220: High Speed Research-Airframe Technology report. with the focus...baseline Ti-6Al-4V (Government Contract No. NASI -20220, High Speed Research-Airframe Technology Report, 1997: 3-5, 14, 26). 1 in 3 in 16 In

Collaborative Research: The Alphabetic Braille and Contracted Braille Study as an Example of Collaborative Research

ERIC Educational Resources Information Center

Wormsley, Diane P.; Emerson, Robert Wall; Erin, Jane

2011-01-01

This article examines the Alphabetic Braille Contracted Braille Study in relation to the dimensions of collaborative research: extent, intensity, substance, heterogeneity, velocity, formality, and productivity. It also discusses the dimensions of financing research and researchers' attitudes. The overall consensus is that the study would not have…

48 CFR 212.7002-1 - Contracts under the program.

Code of Federal Regulations, 2010 CFR

2010-10-01

... for Transition to Follow-On Contracting After Use of Other Transaction Authority 212.7002-1 Contracts under the program. (a) The contracting officer may use FAR part 12 procedures to award a contract for an... process begun as a prototype project under an other transaction agreement or as a research project carried...

Marketing and commercialization of computational research services.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Toevs, J. W.

Physical and computational scientists and mathematicians in Russia's nuclear cities are turning their work toward generating profits from Western markets. Successful ventures require an understanding of the marketing of contract research as well as Western expectations regarding contract execution, quality, and performance. This paper will address fundamentals in business structure, marketing, and contract performance for organizations engaging in the marketing and commercialization of research services. Considerable emphasis will be placed on developing adequate communication within the organization.

Transversus abdominis is part of a global not local muscle synergy during arm movement.

PubMed

Morris, S L; Lay, B; Allison, G T

2013-10-01

The trunk muscle transversus abdominis (TrA) is thought to be controlled independently of the global trunk muscles. Methodological issues in the 1990s research such as unilateral electromyography and a limited range of arm movements justify a re-examination of this theory. The hypothesis tested is that TrA bilateral co-contraction is a typical muscle synergy during arm movement. The activity of 6 pairs of trunk and lower limb muscles was recorded using bilateral electromyography during anticipatory postural adjustments (APAs) associated with the arm movements. The integrated APA electromyographical signals were analyzed for muscle synergy using Principle Component Analysis. TrA does not typically bilaterally co-contract during arm movements (1 out of 6 participants did). APA muscle activity of all muscles during asymmetrical arm movements typically reflected a direction specific diagonal pattern incorporating a twisting motion to transfer energy from the ground up. This finding is not consistent with the hypothesis that TrA plays a unique role providing bilateral, feedforward, multidirectional stiffening of the spine. This has significant implications to the theories underlying the role of TrA in back pain and in the training of isolated bilateral co-contraction of TrA in the prophylaxis of back pain. Crown Copyright © 2013. Published by Elsevier B.V. All rights reserved.

Federal Research and Development Contract Trends and the Supporting Industrial Base, 2000-2014

DTIC Science & Technology

2016-04-30

Homeland Security, and government-wide services contracting trends; sourcing policy and cost estimation methodologies; and recent U.S. Army modernization ...been fears that the sharp downturn in federal contract obligations would disproportionately impact the R&D contracting portfolios within individual...329 - contracting portfolios , and the industrial base that supports those efforts, within each R&D contracting agency. The main finding of this

48 CFR 216.104-70 - Research and development.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Research and development... Contract Types § 216.104-70 Research and development. Follow the procedures at PGI 216.104-70 for selecting the appropriate research and development contract type. [71 FR 39007, July 11, 2006] ...

48 CFR 2052.235-70 - Publication of research results.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Publication of research....235-70 Publication of research results. As prescribed in 2035.70(a)(1), the contracting officer shall insert the following clause in applicable solicitations and contracts for research and development by...

41 CFR 101-29.220 - Market research and analysis.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 41 Public Contracts and Property Management 2 2012-07-01 2012-07-01 false Market research and analysis. 101-29.220 Section 101-29.220 Public Contracts and Property Management Federal Property... PRODUCT DESCRIPTIONS 29.2-Definitions § 101-29.220 Market research and analysis. Market research and...

48 CFR 216.104-70 - Research and development.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Research and development... Contract Types § 216.104-70 Research and development. Follow the procedures at PGI 216.104-70 for selecting the appropriate research and development contract type. [71 FR 39007, July 11, 2006] ...

41 CFR 101-29.220 - Market research and analysis.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Market research and analysis. 101-29.220 Section 101-29.220 Public Contracts and Property Management Federal Property... PRODUCT DESCRIPTIONS 29.2-Definitions § 101-29.220 Market research and analysis. Market research and...

41 CFR 101-29.220 - Market research and analysis.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 41 Public Contracts and Property Management 2 2014-07-01 2012-07-01 true Market research and analysis. 101-29.220 Section 101-29.220 Public Contracts and Property Management Federal Property... PRODUCT DESCRIPTIONS 29.2-Definitions § 101-29.220 Market research and analysis. Market research and...

48 CFR 216.104-70 - Research and development.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Research and development... Contract Types § 216.104-70 Research and development. Follow the procedures at PGI 216.104-70 for selecting the appropriate research and development contract type. [71 FR 39007, July 11, 2006] ...

48 CFR 227.7204 - Contracts under the Small Business Innovation Research Program.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Business Innovation Research Program. 227.7204 Section 227.7204 Federal Acquisition Regulations System... under the Small Business Innovation Research Program. When contracting under the Small Business Innovation Research Program, follow the procedures at 227-7104. [56 FR 36389, July 31, 1991, as amended at 76...

48 CFR 227.7204 - Contracts under the Small Business Innovation Research Program.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Business Innovation Research Program. 227.7204 Section 227.7204 Federal Acquisition Regulations System... under the Small Business Innovation Research Program. When contracting under the Small Business Innovation Research Program, follow the procedures at 227-7104. [56 FR 36389, July 31, 1991, as amended at 76...

48 CFR 227.7204 - Contracts under the Small Business Innovation Research Program.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Business Innovation Research Program. 227.7204 Section 227.7204 Federal Acquisition Regulations System... under the Small Business Innovation Research Program. When contracting under the Small Business Innovation Research Program, follow the procedures at 227-7104. [56 FR 36389, July 31, 1991, as amended at 76...

48 CFR 227.7204 - Contracts under the Small Business Innovation Research Program.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Business Innovation Research Program. 227.7204 Section 227.7204 Federal Acquisition Regulations System... under the Small Business Innovation Research Program. When contracting under the Small Business Innovation Research Program, follow the procedures at 227-7104. [56 FR 36389, July 31, 1991, as amended at 76...

48 CFR 1335.001 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.001 Definitions. Human subject means a living individual...” includes information about behavior that occurs in a context in which an individual can reasonably expect...) in order for obtaining the information to constitute research involving human subjects. Research...

48 CFR 1335.001 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.001 Definitions. Human subject means a living individual...” includes information about behavior that occurs in a context in which an individual can reasonably expect...) in order for obtaining the information to constitute research involving human subjects. Research...

48 CFR 1335.001 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.001 Definitions. Human subject means a living individual...” includes information about behavior that occurs in a context in which an individual can reasonably expect...) in order for obtaining the information to constitute research involving human subjects. Research...

48 CFR 1335.001 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.001 Definitions. Human subject means a living individual...” includes information about behavior that occurs in a context in which an individual can reasonably expect...) in order for obtaining the information to constitute research involving human subjects. Research...

Detection of the electromechanical delay and its components during voluntary isometric contraction of the quadriceps femoris muscle.

PubMed

Begovic, Haris; Zhou, Guang-Quan; Li, Tianjie; Wang, Yi; Zheng, Yong-Ping

2014-01-01

Electromechanical delay (EMD) was described as a time elapsed between first trigger and force output. Various results have been reported based on the measurement method with observed inconsistent results when the trigger is elicited by voluntary contraction. However, mechanomyographic (MMG) sensor placed far away on the skin from the contracting muscle was used to detect muscle fiber motion and excitation-contraction (EC) coupling which may give unreliable results. On this basis, the purpose of this study was to detect EMD during active muscle contraction whilst introducing an ultrafast ultrasound (US) method to detect muscle fiber motion from a certain depth of the muscle. Time delays between onsets of EMG-MMG, EMG-US, MMG-FORCE, US-FORCE, and EMG-FORCE were calculated as 20.5 ± 4.73, 28.63 ± 6.31, 19.21 ± 6.79, 30.52 ± 8.85, and 49.73 ± 6.99 ms, respectively. Intrarater correlation coefficient (ICC) was higher than MMG when ultrafast US was used for detecton of the Δt EMG-US and Δt US-FORCE, ICC values of 0.75 and 0.70, respectively. Synchronization of the ultrafast ultrasound with EMG and FORCE sensors can reveal reliable and clinically useful results related to the EMD and its components when muscle is voluntarily contracted. With ultrafast US, we detect onset from the certain depth of the muscle excluding the tissues above the muscle acting as a low-pass filter which can lead to inaccurate time detection about the onset of the contracting muscle fibers. With this non-invasive technique, understanding of the muscle dynamics can be facilitated.

Activation-dependent descending reflex evacuation motority of anal canal in rat model.

PubMed

Radomirov, Radomir; Negrev, Negrin; Itzev, Dimitar Evlogiev; Stavreva, Galya

2010-12-01

The evacuative motor responses of the anal canal and recto-anal reflexes during defecation were studied in an isolated rat recto-anal model preparation using (i) partitioned organ bath, (ii) electrical stimulation, (iii) balloon distension and (iv) morphological techniques. Electrical field stimulation applied to the anal canal or to the distal part of the rectum elicited tetrodotoxin (10(-7) M)-sensitive frequency-dependent local or descending contractions of the anal canal and the local responses were bigger in amplitude (14.9 ± 1.35 mN) than the descending contractions (5.3 ± 0.7 mN at frequency of 5 Hz, p < 0.05). The balloon-induced distension of the distal rectum evoked descending responses of the anal canal consisting of a short contraction (1.50 ± 0.18 mN) followed by deep relaxation (3.12 ± 0.34 mN). In the presence of atropine (3 x 10(-7) M) the electrically-elicited (5 Hz) local or descending contractions of the anal canal were suppressed and a relaxation revealed. The initial contraction component of the distension-induced response was decreased while the relaxation was not changed. During atropine treatment, spantide (10(-7) M) lowered even more the contractile component of the anal canal response. NG-nitro-L-arginine (5 x 10(-4) M) enhanced the contraction, prevented the atropine-dependent relaxation of the electrically-elicited response and inhibited the distension-induced relaxation. L-Arginine (5 x 10(-4) M) suppressed the contraction and extended the relaxation. ChAT-, substance P- and NADPH-diaphorase-positive perikarya and nerve fibers were observed in myenteric ganglia of the anal canal. The results suggest activation-dependent descending reflex motority of the anal canal involving electrical stimulation-displayed cholinergic and tachykininergic and distension manifested nitrergic neuro-muscular communications.

Endogenous γ-aminobutyric Acid Modulates Tonic Guinea Pig Airway Tone and Propofol-induced Airway Smooth Muscle Relaxation

PubMed Central

Gallos, George; Gleason, Neil R.; Virag, Laszlo; Zhang, Yi; Mizuta, Kentauro; Whittington, Robert A.; Emala, Charles W.

2009-01-01

Background Emerging evidence indicates that an endogenous autocrine/paracrine system involving γ-aminobutyric acid (GABA) is present in airways. GABAA channels, GABAB receptors and the enzyme that synthesizes GABA have been identified in airway epithelium and smooth muscle. However, the endogenous ligand itself, GABA, has not been measured in airway tissues. We sought to demonstrate that GABA is released in response to contractile agonists and tonically contributes a pro-relaxant component to contracted airway smooth muscle. Methods The amount and cellular localization of GABA in upper guinea pig airways under resting and contracted tone was determined by high pressure liquid chromatography and immunohistochemistry, respectively. The contribution that endogenous GABA imparts on the maintenance of airway smooth muscle acetylcholine-induced contraction was assessed in intact guinea pig airway tracheal rings using selective GABAA antagonism (gabazine) under resting or acetylcholine-contracted conditions. The ability of an allosteric agent (propofol) to relax a substance P-induced relaxation in an endogenous GABA-dependent manner was assessed. Results GABA levels increased and localized to airway smooth muscle following contractile stimuli in guinea pig upper airways. Acetylcholine-contracted guinea pig tracheal rings exhibited an increase in contracted force upon addition of the GABAA antagonist gabazine which was subsequently reversed by the addition of the GABAA agonist muscimol. Propofol dose-dependently relaxed a substance P contraction that was blocked by gabazine. Conclusion These studies demonstrate that GABA is endogenously present and increases following contractile stimuli in guinea pig upper airways and that endogenous GABA contributes a tonic pro-relaxant component in the maintenance of airway smooth muscle tone. PMID:19322939

Naval Reactors Prime Contractor Team (NRPCT) Experiences and Considerations With Irradiation Test Performance in an International Environment

DOE Office of Scientific and Technical Information (OSTI.GOV)

MH Lane

2006-02-15

This letter forwards a compilation of knowledge gained regarding international interactions and issues associated with Project Prometheus. The following topics are discussed herein: (1) Assessment of international fast reactor capability and availability; (2) Japanese fast reactor (JOYO) contracting strategy; (3) NRPCT/Program Office international contract follow; (4) Completion of the Japan Atomic Energy Agency (JAEA)/Pacific Northwest National Laboratory (PNNL) contract for manufacture of reactor test components; (5) US/Japanese Departmental interactions and required Treaties and Agreements; and (6) Non-technical details--interactions and considerations.

The Response to High CO2 Levels Requires the Neuropeptide Secretion Component HID-1 to Promote Pumping Inhibition

PubMed Central

Sharabi, Kfir; Charar, Chayki; Friedman, Nurit; Mizrahi, Inbar; Zaslaver, Alon; Sznajder, Jacob I.; Gruenbaum, Yosef

2014-01-01

Carbon dioxide (CO2) is a key molecule in many biological processes; however, mechanisms by which organisms sense and respond to high CO2 levels remain largely unknown. Here we report that acute CO2 exposure leads to a rapid cessation in the contraction of the pharynx muscles in Caenorhabditis elegans. To uncover the molecular mechanisms underlying this response, we performed a forward genetic screen and found that hid-1, a key component in neuropeptide signaling, regulates this inhibition in muscle contraction. Surprisingly, we found that this hid-1-mediated pathway is independent of any previously known pathways controlling CO2 avoidance and oxygen sensing. In addition, animals with mutations in unc-31 and egl-21 (neuropeptide secretion and maturation components) show impaired inhibition of muscle contraction following acute exposure to high CO2 levels, in further support of our findings. Interestingly, the observed response in the pharynx muscle requires the BAG neurons, which also mediate CO2 avoidance. This novel hid-1-mediated pathway sheds new light on the physiological effects of high CO2 levels on animals at the organism-wide level. PMID:25101962

A rotating hot-wire technique for spatial sampling of disturbed and manipulated duct flows

NASA Technical Reports Server (NTRS)

Wark, C. E.; Nagib, H. M.; Jennings, M. J.

1990-01-01

A duct flow spatial sampling technique, in which an X-wire probe is rotated about the center of a cylindrical test section at a radius equal to one-half that of the test section in order to furnish nearly instantaneous multipoint measurements of the streamwise and azimuthal components, is presently evaluated in view of the control of flow disturbances downstream of various open inlet contractions. The effectiveness of a particular contraction in controlling ingested flow disturbances was ascertained by artificially introducing disturbances upstream of the contractions; control effectiveness if found to be strongly dependent on inlet contraction, with consequences for the reduction of passing-blade frequency noise during gas turbine engine ground testing.

48 CFR 207.171-3 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... it is anticipated that a prime contract will be awarded without adequate price competition, and the prime contractor is expected to acquire any component without adequate price competition, the agency... price competition, the agency shall consider breakout of the component if substantial net cost savings...

Static Verification for Code Contracts

NASA Astrophysics Data System (ADS)

Fähndrich, Manuel

The Code Contracts project [3] at Microsoft Research enables programmers on the .NET platform to author specifications in existing languages such as C# and VisualBasic. To take advantage of these specifications, we provide tools for documentation generation, runtime contract checking, and static contract verification.

48 CFR 1335.014 - Government property and title.

Code of Federal Regulations, 2010 CFR

2010-10-01

... primary purpose is the conduct of scientific research is set forth in CAM 1301.70. ... CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.014 Government property and title. The...

48 CFR 1335.014 - Government property and title.

Code of Federal Regulations, 2011 CFR

2011-10-01

... primary purpose is the conduct of scientific research is set forth in CAM 1301.70. ... CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.014 Government property and title. The...

A New Availability-Payment Model for Pricing Performance-Based Logistics Contracts

DTIC Science & Technology

2014-06-17

the contractor maintains a steady revenue (with profit ). Figure 4. Affine Controller Model for Availability Contract Acquisition Research Program... a bankruptcy constraint; and and Deduction(∙) are decision variables for contract design for the level one (public sector) problem. Given...UMD-CM-14-175 ACQUISITION RESEARCH PROGRAM SPONSORED REPORT SERIES A New “Availability-Payment” Model for Pricing Performance- Based

48 CFR 35.011 - Data.

Code of Federal Regulations, 2011 CFR

2011-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.011 Data. (a) R&D contracts shall specify the technical..., drawings, specifications, and other descriptive information) that can be used to achieve competition in...

48 CFR 35.011 - Data.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.011 Data. (a) R&D contracts shall specify the technical..., drawings, specifications, and other descriptive information) that can be used to achieve competition in...

48 CFR 35.011 - Data.

Code of Federal Regulations, 2012 CFR

2012-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.011 Data. (a) R&D contracts shall specify the technical..., drawings, specifications, and other descriptive information) that can be used to achieve competition in...

48 CFR 35.011 - Data.

Code of Federal Regulations, 2014 CFR

2014-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.011 Data. (a) R&D contracts shall specify the technical..., drawings, specifications, and other descriptive information) that can be used to achieve competition in...

48 CFR 35.011 - Data.

Code of Federal Regulations, 2013 CFR

2013-10-01

... CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.011 Data. (a) R&D contracts shall specify the technical..., drawings, specifications, and other descriptive information) that can be used to achieve competition in...

The U.S. Public's Investment in Medical Research: An Evolving Social Contract.

PubMed

Heinig, Stephen J; Dev, Anurupa; Bonham, Ann C

2016-01-01

Medical researchers and their institutions are operating under extraordinary financial stress. More than a decade after completion of the 5-year doubling of the National Institutes of Health budget, the medical research community must confront a significant loss in National Institutes of Health purchasing power and downward pressures in federal discretionary spending. In part, this trend results from a federal budget stalemate over the growth in entitlement programs, particularly spending on medical care. This article considers the changing nature of the federal investment in medical research and the potential for medical researchers and institutions conducting the full spectrum of research to improve health system performance and health equity. In our view, continued federal investments reflect an evolving social contract for research serving the public good; the term contract is used metaphorically to represent a figurative, implicit agreement between the scientific community and the public's representatives in government. Under this conceptual contract, the American people--who are ultimately the funders of research, research training and infrastructure--expect outcomes that lead to better health, security or other benefits. The evolving contract includes expectations for more accountability, transparency, sharing of results and resources, and better integration of research systems and cultures that used to take pride in boundaries and distinctions. We outline here some of the major movements of organizations realigning to social support, which are increasingly essential to sustain public investment in medical research. Copyright © 2016 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

United States private-sector physicians and pharmaceutical contract research: a qualitative study.

PubMed

Fisher, Jill A; Kalbaugh, Corey A

2012-01-01

There have been dramatic increases over the past 20 years in the number of nonacademic, private-sector physicians who serve as principal investigators on US clinical trials sponsored by the pharmaceutical industry. However, there has been little research on the implications of these investigators' role in clinical investigation. Our objective was to study private-sector clinics involved in US pharmaceutical clinical trials to understand the contract research arrangements supporting drug development, and specifically how private-sector physicians engaged in contract research describe their professional identities. We conducted a qualitative study in 2003-2004 combining observation at 25 private-sector research organizations in the southwestern United States and 63 semi-structured interviews with physicians, research staff, and research participants at those clinics. We used grounded theory to analyze and interpret our data. The 11 private-sector physicians who participated in our study reported becoming principal investigators on industry clinical trials primarily because contract research provides an additional revenue stream. The physicians reported that they saw themselves as trial practitioners and as businesspeople rather than as scientists or researchers. Our findings suggest that in addition to having financial motivation to participate in contract research, these US private-sector physicians have a professional identity aligned with an industry-based approach to research ethics. The generalizability of these findings and whether they have changed in the intervening years should be addressed in future studies. Please see later in the article for the Editors' Summary.

United States Private-Sector Physicians and Pharmaceutical Contract Research: A Qualitative Study

PubMed Central

Fisher, Jill A.; Kalbaugh, Corey A.

2012-01-01

Background There have been dramatic increases over the past 20 years in the number of nonacademic, private-sector physicians who serve as principal investigators on US clinical trials sponsored by the pharmaceutical industry. However, there has been little research on the implications of these investigators' role in clinical investigation. Our objective was to study private-sector clinics involved in US pharmaceutical clinical trials to understand the contract research arrangements supporting drug development, and specifically how private-sector physicians engaged in contract research describe their professional identities. Methods and Findings We conducted a qualitative study in 2003–2004 combining observation at 25 private-sector research organizations in the southwestern United States and 63 semi-structured interviews with physicians, research staff, and research participants at those clinics. We used grounded theory to analyze and interpret our data. The 11 private-sector physicians who participated in our study reported becoming principal investigators on industry clinical trials primarily because contract research provides an additional revenue stream. The physicians reported that they saw themselves as trial practitioners and as businesspeople rather than as scientists or researchers. Conclusions Our findings suggest that in addition to having financial motivation to participate in contract research, these US private-sector physicians have a professional identity aligned with an industry-based approach to research ethics. The generalizability of these findings and whether they have changed in the intervening years should be addressed in future studies. Please see later in the article for the Editors' Summary. PMID:22911055

Multi-Task Project to Provide Research Support for Human Research and Engineering Goals Identified by the Army

DTIC Science & Technology

2009-06-01

Jefferson City, MO Phone:573-681-5126 E-mail: rooneyi(a>lincolnu.edu Principle Investigators for contract’s 5 Task Areas: Task I : James Rooney...identified Tasks all structured within a single contract. This contract contained Five Task areas: Task I was an administrative task; Task II-V were...Manager’s Overview of the Report (Task I ) 3. Summary Final Budget Invoice and Budget unspent balance 4. Technical Reports of the Research Tasks (II - V

Contracts for field projects and supporting research on enhanced oil recovery. Progress review number 83, quarter ending June 30, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

Summaries of 41 research projects on enhanced recovery are presented under the following sections: (1) chemical flooding; (2) gas displacement; (3) thermal recovery; (4) geoscience technology; (5) resource assessment technology; and (6) reservoir classes. Each presentation gives the title of the project, contract number, research facility, contract date, expected completion data, amount of the award, principal investigator, and DOE program manager, and describes the objectives of the project and a summary of the technical progress.

48 CFR 5.205 - Special situations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... PUBLICIZING CONTRACT ACTIONS Synopses of Proposed Contract Actions 5.205 Special situations. (a) Research and... interest in potential R&D programs whenever market research does not produce a sufficient number of... subsequent solicitation. Advanced notices must be entitled “Research and Development Sources Sought” and...

48 CFR 5.205 - Special situations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... interest in potential R&D programs whenever market research does not produce a sufficient number of... PUBLICIZING CONTRACT ACTIONS Synopses of Proposed Contract Actions 5.205 Special situations. (a) Research and... subsequent solicitation. Advanced notices must be entitled “Research and Development Sources Sought” and...

DOE Office of Scientific and Technical Information (OSTI.GOV)

James, Brian David; Houchins, Cassidy; Huya-Kouadio, Jennie Moton

The Fuel Cell Technologies Office (FCTO) has identified hydrogen storage as a key enabling technology for advancing hydrogen and fuel cell power technologies in transportation, stationary, and portable applications. Consequently, FCTO has established targets to chart the progress of developing and demonstrating viable hydrogen storage technologies for transportation and stationary applications. This cost assessment project supports the overall FCTO goals by identifying the current technology system components, performance levels, and manufacturing/assembly techniques most likely to lead to the lowest system storage cost. Furthermore, the project forecasts the cost of these systems at a variety of annual manufacturing rates to allowmore » comparison to the overall 2017 and “Ultimate” DOE cost targets. The cost breakdown of the system components and manufacturing steps can then be used to guide future research and development (R&D) decisions. The project was led by Strategic Analysis Inc. (SA) and aided by Rajesh Ahluwalia and Thanh Hua from Argonne National Laboratory (ANL) and Lin Simpson at the National Renewable Energy Laboratory (NREL). Since SA coordinated the project activities of all three organizations, this report includes a technical description of all project activity. This report represents a summary of contract activities and findings under SA’s five year contract to the US Department of Energy (Award No. DE-EE0005253) and constitutes the “Final Scientific Report” deliverable. Project publications and presentations are listed in the Appendix.« less

Improving Functional Magnetic Resonance Imaging Motor Studies Through Simultaneous Electromyography Recordings

PubMed Central

MacIntosh, Bradley J.; Baker, S. Nicole; Mraz, Richard; Ives, John R.; Martel, Anne L.; McIlroy, William E.; Graham, Simon J.

2016-01-01

Specially designed optoelectronic and data postprocessing methods are described that permit electromyography (EMG) of muscle activity simultaneous with functional MRI (fMRI). Hardware characterization and validation included simultaneous EMG and event-related fMRI in 17 healthy participants during either ankle (n = 12), index finger (n = 3), or wrist (n = 2) contractions cued by visual stimuli. Principal component analysis (PCA) and independent component analysis (ICA) were evaluated for their ability to remove residual fMRI gradient-induced signal contamination in EMG data. Contractions of ankle tibialis anterior and index finger abductor were clearly distinguishable, although observing contractions from the wrist flexors proved more challenging. To demonstrate the potential utility of simultaneous EMG and fMRI, data from the ankle experiments were analyzed using two approaches: 1) assuming contractions coincided precisely with visual cues, and 2) using EMG to time the onset and offset of muscle contraction precisely for each participant. Both methods produced complementary activation maps, although the EMG-guided approach recovered more active brain voxels and revealed activity better in the basal ganglia and cerebellum. Furthermore, numerical simulations confirmed that precise knowledge of behavioral responses, such as those provided by EMG, are much more important for event-related experimental designs compared to block designs. This simultaneous EMG and fMRI methodology has important applications where the amplitude or timing of motor output is impaired, such as after stroke. PMID:17133382

Improving functional magnetic resonance imaging motor studies through simultaneous electromyography recordings.

PubMed

MacIntosh, Bradley J; Baker, S Nicole; Mraz, Richard; Ives, John R; Martel, Anne L; McIlroy, William E; Graham, Simon J

2007-09-01

Specially designed optoelectronic and data postprocessing methods are described that permit electromyography (EMG) of muscle activity simultaneous with functional MRI (fMRI). Hardware characterization and validation included simultaneous EMG and event-related fMRI in 17 healthy participants during either ankle (n = 12), index finger (n = 3), or wrist (n = 2) contractions cued by visual stimuli. Principal component analysis (PCA) and independent component analysis (ICA) were evaluated for their ability to remove residual fMRI gradient-induced signal contamination in EMG data. Contractions of ankle tibialis anterior and index finger abductor were clearly distinguishable, although observing contractions from the wrist flexors proved more challenging. To demonstrate the potential utility of simultaneous EMG and fMRI, data from the ankle experiments were analyzed using two approaches: 1) assuming contractions coincided precisely with visual cues, and 2) using EMG to time the onset and offset of muscle contraction precisely for each participant. Both methods produced complementary activation maps, although the EMG-guided approach recovered more active brain voxels and revealed activity better in the basal ganglia and cerebellum. Furthermore, numerical simulations confirmed that precise knowledge of behavioral responses, such as those provided by EMG, are much more important for event-related experimental designs compared to block designs. This simultaneous EMG and fMRI methodology has important applications where the amplitude or timing of motor output is impaired, such as after stroke. (c) 2006 Wiley-Liss, Inc.

Contracts.

ERIC Educational Resources Information Center

Gellert, Shepard D.; Wilson, Grace

1977-01-01

This paper reviews experimental psychology goal research and its implications for the therapist doing contract therapy. Clinical examples of various levels of contracts give illustrations, and a technique, the therapeutic double bind, as a form of contract, is detailed. A case study is presented to illustrate the use of the theory. Three…

Ultrasonic transducer for extreme temperature environments

DOEpatents

Light, Glenn M.; Cervantes, Richard A.; Alcazar, David G.

1993-03-23

An ultrasonic piezoelectric transducer that is operable in very high and very low temperatures. The transducer has a dual housing structure that isolates the expansion and contraction of the piezoelectric element from the expansion and contraction of the housing. Also, the internal components are made from materials having similar coefficients of expansion so that they do not interfere with the motion of the piezoelectric element.

High Speed Research Noise Prediction Code (HSRNOISE) User's and Theoretical Manual

NASA Technical Reports Server (NTRS)

Golub, Robert (Technical Monitor); Rawls, John W., Jr.; Yeager, Jessie C.

2004-01-01

This report describes a computer program, HSRNOISE, that predicts noise levels for a supersonic aircraft powered by mixed flow turbofan engines with rectangular mixer-ejector nozzles. It fully documents the noise prediction algorithms, provides instructions for executing the HSRNOISE code, and provides predicted noise levels for the High Speed Research (HSR) program Technology Concept (TC) aircraft. The component source noise prediction algorithms were developed jointly by Boeing, General Electric Aircraft Engines (GEAE), NASA and Pratt & Whitney during the course of the NASA HSR program. Modern Technologies Corporation developed an alternative mixer ejector jet noise prediction method under contract to GEAE that has also been incorporated into the HSRNOISE prediction code. Algorithms for determining propagation effects and calculating noise metrics were taken from the NASA Aircraft Noise Prediction Program.

48 CFR 1352.235-73 - Research involving human subjects-after initial contract award.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Research involving human... Provisions and Clauses 1352.235-73 Research involving human subjects—after initial contract award. As prescribed in 48 CFR 1335.006(d), insert the following clause: Research Involving Human Subjects—After...

48 CFR 1352.235-73 - Research involving human subjects-after initial contract award.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Research involving human... Provisions and Clauses 1352.235-73 Research involving human subjects—after initial contract award. As prescribed in 48 CFR 1335.006(d), insert the following clause: Research Involving Human Subjects—After...

48 CFR 1352.235-73 - Research involving human subjects-after initial contract award.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Research involving human... Provisions and Clauses 1352.235-73 Research involving human subjects—after initial contract award. As prescribed in 48 CFR 1335.006(d), insert the following clause: Research Involving Human Subjects—After...

Hedgehogs, Foxes, Ethics, and the Evolving Social Contract in Psychology.

ERIC Educational Resources Information Center

Rosnow, Ralph L.

This paper discusses the importance of ethics in psychological research. It defines the social contract between psychological science and society as the responsibility not to do psychological or physical harm to any research participants and to do beneficial research in a way that will produce valid research. Also explored are ways in which…

Small Business Innovation Research GRC Phase I, Phase II, and Post-Phase II Opportunity Assessment for 2015

NASA Technical Reports Server (NTRS)

Nguyen, Hung D.; Steele, Gynelle C.

2016-01-01

This report outlines the 2015 Small Business Innovation Research/Small Business Technology Transfer (SBIR/STTR) Phase I, Phase II, and Post-Phase II opportunity contract award results associated with NASA's Aeronautics Research Mission Directorate (ARMD), Human Exploration and Operations Mission Directorate (HEOMD), Science Mission Directorate (SMD), and Space Technology Mission Directorate (STMD) for NASA Glenn Research Center. The report also highlights the number of Phase I, Phase II, and Post-Phase II contracts awarded by mission directorate. The 2015 Phase I contract awards to companies in Ohio and their corresponding technologies are also discussed.

Age 60 rule research, part I : bibliographic database.

DOT National Transportation Integrated Search

1994-10-01

This document is one of four products completed as a part of the Age 60 Rule research contract monitored by Pam Della Rocco, Civil Aerospace Medical Institute. As part of their research contract with the FAA to study issues related to the "Age 60 Rul...

48 CFR 1832.412 - Contract clause. (NASA supplement paragraphs (e) and (f))

Code of Federal Regulations, 2014 CFR

2014-10-01

... AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Advance Payments for... the Small Business Innovation Research (SBIR) or Small Business Technology Transfer (STTR) programs...

48 CFR 1832.412 - Contract clause. (NASA supplement paragraphs (e) and (f))

Code of Federal Regulations, 2011 CFR

2011-10-01

... AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Advance Payments for... the Small Business Innovation Research (SBIR) or Small Business Technology Transfer (STTR) programs...

48 CFR 1832.412 - Contract clause. (NASA supplement paragraphs (e) and (f))

Code of Federal Regulations, 2010 CFR

2010-10-01

... AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Advance Payments for... the Small Business Innovation Research (SBIR) or Small Business Technology Transfer (STTR) programs...

48 CFR 1832.412 - Contract clause. (NASA supplement paragraphs (e) and (f))

Code of Federal Regulations, 2012 CFR

2012-10-01

... AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Advance Payments for... the Small Business Innovation Research (SBIR) or Small Business Technology Transfer (STTR) programs...

48 CFR 1832.412 - Contract clause. (NASA supplement paragraphs (e) and (f))

Code of Federal Regulations, 2013 CFR

2013-10-01

... AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING Advance Payments for... the Small Business Innovation Research (SBIR) or Small Business Technology Transfer (STTR) programs...

Enhancements to the Engine Data Interpretation System (EDIS)

NASA Technical Reports Server (NTRS)

Hofmann, Martin O.

1993-01-01

The Engine Data Interpretation System (EDIS) expert system project assists the data review personnel at NASA/MSFC in performing post-test data analysis and engine diagnosis of the Space Shuttle Main Engine (SSME). EDIS uses knowledge of the engine, its components, and simple thermodynamic principles instead of, and in addition to, heuristic rules gathered from the engine experts. EDIS reasons in cooperation with human experts, following roughly the pattern of logic exhibited by human experts. EDIS concentrates on steady-state static faults, such as small leaks, and component degradations, such as pump efficiencies. The objective of this contract was to complete the set of engine component models, integrate heuristic rules into EDIS, integrate the Power Balance Model into EDIS, and investigate modification of the qualitative reasoning mechanisms to allow 'fuzzy' value classification. The results of this contract is an operational version of EDIS. EDIS will become a module of the Post-Test Diagnostic System (PTDS) and will, in this context, provide system-level diagnostic capabilities which integrate component-specific findings provided by other modules.

Enhancements to the Engine Data Interpretation System (EDIS)

NASA Technical Reports Server (NTRS)

Hofmann, Martin O.

1993-01-01

The Engine Data Interpretation System (EDIS) expert system project assists the data review personnel at NASA/MSFC in performing post-test data analysis and engine diagnosis of the Space Shuttle Main Engine (SSME). EDIS uses knowledge of the engine, its components, and simple thermodynamic principles instead of, and in addition to, heuristic rules gathered from the engine experts. EDIS reasons in cooperation with human experts, following roughly the pattern of logic exhibited by human experts. EDIS concentrates on steady-state static faults, such as small leaks, and component degradations, such as pump efficiencies. The objective of this contract was to complete the set of engine component models, integrate heuristic rules into EDIS, integrate the Power Balance Model into EDIS, and investigate modification of the qualitative reasoning mechanisms to allow 'fuzzy' value classification. The result of this contract is an operational version of EDIS. EDIS will become a module of the Post-Test Diagnostic System (PTDS) and will, in this context, provide system-level diagnostic capabilities which integrate component-specific findings provided by other modules.

Magnetic resonance imaging demonstrates compartmental muscle mechanisms of human vertical fusional vergence

PubMed Central

Clark, Robert A.

2015-01-01

Vertical fusional vergence (VFV) normally compensates for slight vertical heterophorias. We employed magnetic resonance imaging to clarify extraocular muscle contributions to VFV induced by monocular two-prism diopter (1.15°) base-up prism in 14 normal adults. Fusion during prism viewing requires monocular infraduction. Scans were repeated without prism, and with prism shifted contralaterally. Contractility indicated by morphometric indexes was separately analyzed in medial and lateral vertical rectus and superior oblique (SO) putative compartments, and superior and inferior horizontal rectus extraocular muscle putative compartments, but in the whole inferior oblique (IO). Images confirmed appropriate VFV that was implemented by the inferior rectus (IR) medial compartment contracting ipsilateral and relaxing contralateral to prism. There was no significant contractility in the IR lateral compartment. The superior but not inferior lateral rectus (LR) compartment contracted significantly in the prism viewing eye, but not contralateral to prism. The IO contracted ipsilateral but not contralateral to the prism. In the infraducting eye, the SO medial compartment relaxed significantly, while the lateral compartment was unchanged; contralateral to prism, the SO lateral compartment contracted, while the medial compartment was unchanged. There was no contractility in the superior or medial rectus muscles in either eye. There was no globe retraction. We conclude that the vertical component of VFV is primarily implemented by IR medial compartment contraction. Since appropriate vertical rotation is not directly implemented, or is opposed, by associated differential LR and SO compartmental activity, and IO contraction, these actions probably implement a torsional component of VFV. PMID:25589593

Army Contract Specialists’ Lack of Desire to Become Contracting Officers

DTIC Science & Technology

2012-05-01

management positions. In researching this matter, the author will utilize a mixed method research approach which employs both qualitative and...literature available and relevance. Chapter 3 presents the methods used to conduct the research and discusses why qualitative interviews and survey research ...This research study will utilize a qualitative method with roots in traditional ethnographic research , in helping to achieve the objective of

Frequency dependence of excitation-contraction of multicellular smooth muscle preparations: the relevance to bipolar electrosurgery.

PubMed

Vladimirova, Irina A; Lankin, Yuri N; Philyppov, Igor B; Sushiy, Lyudmyla F; Shuba, Yaroslav M

2014-01-01

Bipolar electrosurgical tissue welding uses forceps-like electrodes for grasping the tissues and delivering high-frequency electric current (HFEC) to produce local heat, desiccation, and protein denaturation, resulting in the fusion of the contacting tissues. Although in this technique no electric current is flowing through the whole body to cause electric injury, depending on the frequency of applied energy, it may produce local excitation of intramural nerves, which can propagate beyond the surgical site potentially causing harmful effects. The effects of varying frequency of HFEC on tissue excitability in bipolar electrosurgical modality were studied in vitro using electric field stimulation (EFS) method on multicellular smooth muscle strips of rat vas deferens. Contractile response to 5-s-long sine wave EFS train was taken as the measure of excitation of intramural nerves. EFS-induced contraction consisted of phasic and tonic components. The amplitude of both components decreased with increasing frequency, with tonic component disappearing at about 10 kHz and phasic component at about 50 kHz. Because components of EFS-induced contraction depend on different neurotransmitters, this indicates that various neurotransmitter systems are characterized by distinct frequency dependence, but above 50 kHz they all become inactivated. Bipolar electrosurgical sealing of porcine gut showed no difference in the structure of seal area at HFEC of 67 and 533 kHz. EFS frequency of 50 kHz represents the upper limit for excitation. HFEC above 50 kHz is safe to use for bipolar electrosurgical tissue welding without concerns of excitation propagating beyond the surgical site. Copyright © 2014 Elsevier Inc. All rights reserved.

Charitable State-Controlled Foundation Human Tissue and Cell Research: Ethic and Legal Aspects in the Supply of Surgically Removed Human Tissue For Research in the Academic and Commercial Sector in Germany.

PubMed

Thasler, Wolfgang E.; Weiss, Thomas S.; Schillhorn, Kerrin; Stoll, Peter-Tobias; Irrgang, Bernhard; Jauch, Karl-Walter

2003-01-01

Tissue engineering using human cells and tissue has one of the greatest scientific and economical potential in the coming years. There are public concerns during the ongoing discussion about future trends in life sciences and if ethic boundaries might be respected sufficiently in the course of striving for industrial profit and scientific knowledge. Until now, the legal situation of using human tissue material for research is not clear. Accordingly, transparency of action and patients' information are a central component when handling patient material inside and outside of the patient-specific treatment. Whereas in the field of therapeutic use of tissue (e.g. transplantation) there is an emergency situation by the shortage of organs with the risk of the premature death of the potential recipient, this cannot be claimed for tissue donation for research. The basis of every surgical operation is the treatment contract, which places the doctor under obligation to the careful exercise of medical treatment containing the patient's informed consent. This contract only covers the treatment that is intended to cure the patient and the medical measures that are necessary therefor. The further scientific use of body-substances, which are discarded after an operation, are not included. Therefore a personal and independent written enlightenment of the patient and a declaration of informed consent is necessary. Examples of guidelines for tissue supply, Patients information and consent were worked out by theologists, lawyers, scientists and physicians reflecting their practical experience in transplant surgery and liver cell research. As a consequence to cover the ethical and legal aspect of tissue donation in Germany a charitable state-controlled foundation Human Tissue and Cell Research (HTCR) was introduced and established.

Campaign contributions, lobbying and post-Katrina contracts.

PubMed

Hogan, Michael J; Long, Michael A; Stretesky, Paul B

2010-07-01

This research explores the relationship between political campaign contributions, lobbying and post-Hurricane Katrina cleanup and reconstruction contracts. Specifically, a case-control study design is used to determine whether campaign contributions to national candidates in the 2000-04 election cycles and/or the employment of lobbyists and lobbying firms increased a company's probability of receiving a post-hurricane contract. Results indicate that both a campaign contribution dichotomous variable and the dollar amount of contributions are significantly related to whether a company received a contract, but that lobbying activity was not. These findings are discussed in the context of previous research on the politics of natural disasters, government contracting and governmental and corporate deviance.

Air Force Needs Better Processes to Appropriately Justify and Manage Cost-Reimbursable Contracts

DTIC Science & Technology

2013-03-21

Contracts Reviewed 4 The Small Business Innovation Research Program 4 Review of Internal Controls 5 ...stimulate high-tech innovation, and increase private-sector commercialization. The SBIR 5 program was established under the Small Business...contracts valued at about $7.4 billion. 5 According to the Office of Federal Procurement Policy, a hybrid contract allows contracting officers to

Research on Non-Lethal Stunning/Immobilizing Weapons

DTIC Science & Technology

2007-04-01

release, skeletal muscle contraction , on-line and real-time monitoring of bioeffects 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF 18. NUMBER 19a. NAME...and growth of on-going research projects in which non-thermal radiofrequency /microwave (RF/MW) effects on skeletal muscle contraction and...for studying nonthermal effects on skeletal muscle contraction . IEEE Transactions on Plasma Science, 34, 1470-1479. Thesis Bindya Dumpala completed

48 CFR 1832.501-1 - Customary progress payment rates. (NASA supplements paragraph (a))

Code of Federal Regulations, 2012 CFR

2012-10-01

... System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING... II contracts in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer...

48 CFR 1832.501-1 - Customary progress payment rates. (NASA supplements paragraph (a))

Code of Federal Regulations, 2014 CFR

2014-10-01

... System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING... II contracts in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer...

48 CFR 1832.501-1 - Customary progress payment rates. (NASA supplements paragraph (a))

Code of Federal Regulations, 2011 CFR

2011-10-01

... System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING... II contracts in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer...

48 CFR 1832.501-1 - Customary progress payment rates. (NASA supplements paragraph (a))

Code of Federal Regulations, 2013 CFR

2013-10-01

... System NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GENERAL CONTRACTING REQUIREMENTS CONTRACT FINANCING... II contracts in the Small Business Innovation Research (SBIR) and Small Business Technology Transfer...

48 CFR 2442.1107 - Contract clause.

Code of Federal Regulations, 2014 CFR

2014-10-01

... requires services of an analytical nature (e.g., applied social science research); and (3) The contract requires the delivery of an overall end product (e.g., evaluation, study, model). (b) The Contracting...

48 CFR 2442.1107 - Contract clause.

Code of Federal Regulations, 2013 CFR

2013-10-01

... requires services of an analytical nature (e.g., applied social science research); and (3) The contract requires the delivery of an overall end product (e.g., evaluation, study, model). (b) The Contracting...

Tale of a Performance Contract

ERIC Educational Resources Information Center

Berson, Minnie Perrin

1971-01-01

Excerpts from Texarkana and Gary: A Tale of Two Performance Contracts," Childhood Education Magazine, March 1971; reports on observations made during visit to Gary, Indiana, school under contract to Behavioral Research Laboratories. (RT)

Uterine Contraction Modeling and Simulation

NASA Technical Reports Server (NTRS)

Liu, Miao; Belfore, Lee A.; Shen, Yuzhong; Scerbo, Mark W.

2010-01-01

Building a training system for medical personnel to properly interpret fetal heart rate tracing requires developing accurate models that can relate various signal patterns to certain pathologies. In addition to modeling the fetal heart rate signal itself, the change of uterine pressure that bears strong relation to fetal heart rate and provides indications of maternal and fetal status should also be considered. In this work, we have developed a group of parametric models to simulate uterine contractions during labor and delivery. Through analysis of real patient records, we propose to model uterine contraction signals by three major components: regular contractions, impulsive noise caused by fetal movements, and low amplitude noise invoked by maternal breathing and measuring apparatus. The regular contractions are modeled by an asymmetric generalized Gaussian function and least squares estimation is used to compute the parameter values of the asymmetric generalized Gaussian function based on uterine contractions of real patients. Regular contractions are detected based on thresholding and derivative analysis of uterine contractions. Impulsive noise caused by fetal movements and low amplitude noise by maternal breathing and measuring apparatus are modeled by rational polynomial functions and Perlin noise, respectively. Experiment results show the synthesized uterine contractions can mimic the real uterine contractions realistically, demonstrating the effectiveness of the proposed algorithm.

The Patient Protection and Affordable Care Act and Reproductive Health: Harnessing Data to Improve Care

PubMed Central

Stulberg, Debra

2013-01-01

The Patient Protection and Affordable Care Act (PPACA) has great potential to improve reproductive health through several components: expanded coverage of people of reproductive age; required coverage of many reproductive health services; and insurance exchange structures that encourage individuals and states to hold plans and providers accountable. These components can work together to improve reproductive health. But in order for this to work, consumers and states need information with which to assess plans. This review article summarizes state contracting theory and argues that states should use this structure to require health plans to collect and report meaningful data that patients, providers, plans, payers, and third-party researchers can access. Now that the Supreme Court has upheld the PPACA and states must set up health insurance exchanges, populations can benefit from improved care and outcomes through data transparency. PMID:23262767

Correlation Between Hot Spots and 3-d Defect Structure in Single and Polycrystalline High-explosive Materials

NASA Astrophysics Data System (ADS)

Hawkins, Cameron; Tschuaner, Oliver; Fussell, Zachary; Smith, Jesse

2017-06-01

A novel approach that spatially identifies inhomogeneities from microscale (defects, con-formational disorder) to mesoscale (voids, inclusions) is developed using synchrotron x-ray methods: tomography, Lang topography, and micro-diffraction mapping. These techniques pro-vide a non-destructive method for characterization of mm-sized samples prior to shock experiments. These characterization maps can be used to correlate continuum level measurements in shock compression experiments to the mesoscale and microscale structure. Specifically examined is a sample of C4. We show extensive conformational disorder in gamma-RDX, which is the main component. Further, we observe that the minor HMX-component in C4 contains at least two different phases: alpha- and beta-HMX. This work supported by National Security Technologies, LLC, under Contract No. DE-AC52-06NA25946 with the U.S. Department of Energy and by the Site-Directed Research and Development Program. DOE/NV/25946-3071.

48 CFR 35.016 - Broad agency announcement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Scientific Review (see 6.102(d)(2)) for the acquisition of basic and applied research and that part of... CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.016 Broad agency announcement. (a) General... documents, shall— (1) Describe the agency's research interest, either for an individual program requirement...

48 CFR 53.235 - Research and Development Contracting (SF 298).

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Research and Development... REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.235 Research and Development... scientific and technical reports to contracting officers and to technical information libraries, as specified...

48 CFR 53.235 - Research and Development Contracting (SF 298).

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Research and Development... REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.235 Research and Development... scientific and technical reports to contracting officers and to technical information libraries, as specified...

48 CFR 53.235 - Research and Development Contracting (SF 298).

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Research and Development... REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.235 Research and Development... scientific and technical reports to contracting officers and to technical information libraries, as specified...

48 CFR 53.235 - Research and Development Contracting (SF 298).

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Research and Development... REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.235 Research and Development... scientific and technical reports to contracting officers and to technical information libraries, as specified...

48 CFR 53.235 - Research and Development Contracting (SF 298).

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Research and Development... REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.235 Research and Development... scientific and technical reports to contracting officers and to technical information libraries, as specified...

48 CFR 2442.1107 - Contract clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... analytical nature (e.g., applied social science research); and (3) The contract requires the delivery of an overall end product (e.g., evaluation, study, model). (b) The Contracting Officer shall use the basic...

48 CFR 2442.1107 - Contract clause.

Code of Federal Regulations, 2012 CFR

2012-10-01

... analytical nature (e.g., applied social science research); and (3) The contract requires the delivery of an overall end product (e.g., evaluation, study, model). (b) The Contracting Officer shall use the basic...

48 CFR 2442.1107 - Contract clause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... analytical nature (e.g., applied social science research); and (3) The contract requires the delivery of an overall end product (e.g., evaluation, study, model). (b) The Contracting Officer shall use the basic...

48 CFR 16.504 - Indefinite-quantity contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... quantity based on market research, trends on recent contracts for similar supplies or services, survey of... are unique or highly specialized; (2) Based on the contracting officer's knowledge of the market, more...

10 CFR 733.7 - Referral to the contracting officer.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Referral to the contracting officer. 733.7 Section 733.7 Energy DEPARTMENT OF ENERGY ALLEGATIONS OF RESEARCH MISCONDUCT § 733.7 Referral to the contracting... misconduct, the DOE Element should forward the allegation to the contracting officer responsible for...

10 CFR 733.7 - Referral to the contracting officer.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Referral to the contracting officer. 733.7 Section 733.7 Energy DEPARTMENT OF ENERGY ALLEGATIONS OF RESEARCH MISCONDUCT § 733.7 Referral to the contracting... misconduct, the DOE Element should forward the allegation to the contracting officer responsible for...

10 CFR 733.7 - Referral to the contracting officer.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Referral to the contracting officer. 733.7 Section 733.7 Energy DEPARTMENT OF ENERGY ALLEGATIONS OF RESEARCH MISCONDUCT § 733.7 Referral to the contracting... misconduct, the DOE Element should forward the allegation to the contracting officer responsible for...

10 CFR 733.7 - Referral to the contracting officer.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Referral to the contracting officer. 733.7 Section 733.7 Energy DEPARTMENT OF ENERGY ALLEGATIONS OF RESEARCH MISCONDUCT § 733.7 Referral to the contracting... misconduct, the DOE Element should forward the allegation to the contracting officer responsible for...

10 CFR 733.7 - Referral to the contracting officer.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Referral to the contracting officer. 733.7 Section 733.7 Energy DEPARTMENT OF ENERGY ALLEGATIONS OF RESEARCH MISCONDUCT § 733.7 Referral to the contracting... misconduct, the DOE Element should forward the allegation to the contracting officer responsible for...

48 CFR 1835.070 - NASA contract clauses and solicitation provision.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false NASA contract clauses and....070 NASA contract clauses and solicitation provision. (a) The contracting officer shall insert the... ensure that the provision at 1852.235-72, Instructions for Responding to NASA Research Announcements, is...

48 CFR 1835.070 - NASA contract clauses and solicitation provision.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true NASA contract clauses and....070 NASA contract clauses and solicitation provision. (a) The contracting officer shall insert the... ensure that the provision at 1852.235-72, Instructions for Responding to NASA Research Announcements, is...

48 CFR 1835.070 - NASA contract clauses and solicitation provision.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false NASA contract clauses and....070 NASA contract clauses and solicitation provision. (a) The contracting officer shall insert the... ensure that the provision at 1852.235-72, Instructions for Responding to NASA Research Announcements, is...

48 CFR 1835.070 - NASA contract clauses and solicitation provision.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false NASA contract clauses and....070 NASA contract clauses and solicitation provision. (a) The contracting officer shall insert the... ensure that the provision at 1852.235-72, Instructions for Responding to NASA Research Announcements, is...

48 CFR 1835.070 - NASA contract clauses and solicitation provision.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false NASA contract clauses and....070 NASA contract clauses and solicitation provision. (a) The contracting officer shall insert the... ensure that the provision at 1852.235-72, Instructions for Responding to NASA Research Announcements, is...

48 CFR 37.000 - Scope of part.

Code of Federal Regulations, 2013 CFR

2013-10-01

... specific to the acquisition and management of services by contract. This part applies to all contracts and...). Additional guidance for research and development services is in part 35; architect-engineering services is in... not limited to, contracts for services to which the Service Contract Act of 1965, as amended, applies...

48 CFR 37.000 - Scope of part.

Code of Federal Regulations, 2010 CFR

2010-10-01

... specific to the acquisition and management of services by contract. This part applies to all contracts and...). Additional guidance for research and development services is in part 35; architect-engineering services is in... not limited to, contracts for services to which the Service Contract Act of 1965, as amended, applies...

Evaluation of contract time estimation and contracting procedures for louisiana department of transportation and development construction projects : final report : volume I.

DOT National Transportation Integrated Search

1995-09-11

The purpose of the research was to provide the Louisiana Department of Transportation and Development (LaDOTD) with a systematic approach to the determination of contract time and to explore innovative contracting procedures that may prove beneficial...

75 FR 71562 - Defense Federal Acquisition Regulation Supplement; Contract Authority for Advanced Component...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-24

... Development or Prototype Units (DFARS Case 2009-D034) AGENCY: Defense Acquisition Regulations System... the procurement of prototype units. The DFARS implementation places specific limits, in accordance... components or the procurement of prototype units. IV. Paperwork Reduction Act The Paperwork Reduction Act...

48 CFR 4.803 - Contents of contract files.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the type and extent of market research conducted. (7) Government estimate of contract price. (8) A... documentation— (i) Of the type and extent of market research; and (ii) That the NAICS code assigned to the...

45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

Code of Federal Regulations, 2013 CFR

2013-10-01

... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development work...

45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

Code of Federal Regulations, 2011 CFR

2011-10-01

... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development work...

45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

Code of Federal Regulations, 2010 CFR

2010-10-01

... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development work...

45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

Code of Federal Regulations, 2014 CFR

2014-10-01

... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development work...

45 CFR Appendix E to Part 74 - Principles for Determining Costs Applicable to Research and Development Under Grants and...

Code of Federal Regulations, 2012 CFR

2012-10-01

... Research and Development Under Grants and Contracts With Hospitals E Appendix E to Part 74 Public Welfare... Research and Development Under Grants and Contracts With Hospitals i. purpose and scope A. Objectives. This appendix provides principles for determining the costs applicable to research and development work...

Two-wave model of the muscle contraction.

PubMed

Molski, Marcin

2009-05-01

The Matsuno model of the muscle contraction is considered in the framework of the two-wave Corben's theory of composite objects built up of both time- and space-like components. It has been proved that during muscle contraction the locally coherent aggregates distributed along the actin filament interact by means of space-like fields, which are solutions of the relativistic Feinberg equation. The existence of such interactions and lack of decoherence are conditions sine qua non for appearance of the quantum entanglement between actin monomers in an ATP-activated filament. A possible role of a quantum potential in the muscle contraction is discussed and the mass of the carrier of space-like interactions is estimated m0' = 7.3 x 10(-32) g (46 eV).

Recent manufacturing advances for spiral bevel gears

NASA Technical Reports Server (NTRS)

Handschuh, Robert F.; Bill, Robert C.

1991-01-01

The U.S. Army Aviation Systems Command (AVSCOM), through the Propulsion Directorate at NASA Lewis Research Center, has recently sponsored projects to advance the manufacturing process for spiral bevel gears. This type of gear is a critical component in rotary-wing propulsion systems. Two successfully completed contracted projects are described. The first project addresses the automated inspection of spiral bevel gears through the use of coordinate measuring machines. The second project entails the computer-numerical-control (CNC) conversion of a spiral bevel gear grinding machine that is used for all aerospace spiral bevel gears. The results of these projects are described with regard to the savings effected in manufacturing time.

Flow of a Gas Turbine Engine Low-Pressure Subsystem Simulated

NASA Technical Reports Server (NTRS)

Veres, Joseph P.

1997-01-01

The NASA Lewis Research Center is managing a task to numerically simulate overnight, on a parallel computing testbed, the aerodynamic flow in the complete low-pressure subsystem (LPS) of a gas turbine engine. The model solves the three-dimensional Navier- Stokes flow equations through all the components within the LPS, as well as the external flow around the engine nacelle. The LPS modeling task is being performed by Allison Engine Company under the Small Engine Technology contract. The large computer simulation was evaluated on networked computer systems using 8, 16, and 32 processors, with the parallel computing efficiency reaching 75 percent when 16 processors were used.

Research to Support Intelligent Data Management

NASA Technical Reports Server (NTRS)

Lerner, B. T.

1998-01-01

This final report details the contract performance and analysis of research and development results obtained during the contract period. KT-Tech's research and development work results in the areas of registration of remotely sensed data and the test evaluation and porting of the Regional Validation Center software system are presented.

48 CFR 1816.303-70 - Cost-sharing contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... organizations is mandatory in any contract for basic or applied research resulting from an unsolicited proposal... the research, and the contractor has no means of recovering its shared costs on such projects. (2) The... contribution from non-Federal sources; (ii) The extent to which the particular area of research requires...

Research to Support Intelligent Data Management

NASA Technical Reports Server (NTRS)

Lerner, Bao-Ting

1998-01-01

This final report details the contract performance and analysis of research and development results obtained during the contract period. KT-TECH's research and development work results in the areas of registration of remotely sensed data and the test evaluation and porting of the Regional Validation Center software system, are presented.

21 CFR 312.23 - IND content and format.

Code of Federal Regulations, 2014 CFR

2014-04-01

... proposed changes in the research activity in accordance with the requirements of part 56. (v) A commitment... obligations for the conduct of any clinical study to a contract research organization, a statement containing the name and address of the contract research organization, identification of the clinical study, and...

21 CFR 312.23 - IND content and format.

Code of Federal Regulations, 2011 CFR

2011-04-01

... proposed changes in the research activity in accordance with the requirements of part 56. (v) A commitment... obligations for the conduct of any clinical study to a contract research organization, a statement containing the name and address of the contract research organization, identification of the clinical study, and...

21 CFR 312.23 - IND content and format.

Code of Federal Regulations, 2012 CFR

2012-04-01

... proposed changes in the research activity in accordance with the requirements of part 56. (v) A commitment... obligations for the conduct of any clinical study to a contract research organization, a statement containing the name and address of the contract research organization, identification of the clinical study, and...

21 CFR 312.23 - IND content and format.

Code of Federal Regulations, 2010 CFR

2010-04-01

... proposed changes in the research activity in accordance with the requirements of part 56. (v) A commitment... obligations for the conduct of any clinical study to a contract research organization, a statement containing the name and address of the contract research organization, identification of the clinical study, and...

21 CFR 312.23 - IND content and format.

Code of Federal Regulations, 2013 CFR

2013-04-01

... proposed changes in the research activity in accordance with the requirements of part 56. (v) A commitment... obligations for the conduct of any clinical study to a contract research organization, a statement containing the name and address of the contract research organization, identification of the clinical study, and...

Performance-Based Service Acquisition (PBSA) Study and Graduate Level Course Material

DTIC Science & Technology

2005-12-01

Realizing Marketplace Potential, Acquisition Solutions, Inc (Advisory), February 2001 Dickson, Bob, March 10, 2003. Federal 7 Contract Law : Feds...Management and Policy Federal Contract Law : Feds should use market research to refine IT plans Session 4: The Performance Requirements and...March 10, 2003. Federal Contract Law : Feds should use market research to refine IT plans, Post-Newsweek Media, Inchttp://appserv.gcn.com/cgi- bin/udt

Synthesis of 1,3-Dinitrohexahydropyrimidine via Ring Contraction of Ether-Linked Nitramines

DTIC Science & Technology

2016-07-01

ARL-TR-7706 ● JULY 2016 US Army Research Laboratory Synthesis of 1,3-Dinitrohexahydropyrimidine via Ring Contraction of Ether...JULY 2016 US Army Research Laboratory Synthesis of 1,3-Dinitrohexahydropyrimidine via Ring Contraction of Ether-Linked Nitramines by...YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) July 2016 2. REPORT TYPE Final 3. DATES COVERED (From - To) Fiscal Year 2013 4. TITLE

Radial stiffness characteristics of the overlap regions of sarcomeres in isolated skeletal myofibrils in pre-force generating state.

PubMed

Miyashiro, Daisuke; Ohtsuki, Misato; Shimamoto, Yuta; Wakayama, Jun'ichi; Kunioka, Yuki; Kobayashi, Takakazu; Ishiwata, Shin'ichi; Yamada, Takenori

2017-01-01

We have studied the stiffness of myofilament lattice in sarcomeres in the pre-force generating state, which was realized by a relaxing reagent, BDM (butane dione monoxime). First, the radial stiffness for the overlap regions of sarcomeres of isolated single myofibrils was estimated from the resulting decreases in diameter by osmotic pressure applied with the addition of Dextran. Then, the radial stiffness was also estimated from force-distance curve measurements with AFM technology. The radial stiffness for the overlap regions thus obtained was composed of a soft and a rigid component. The soft component visco-elastically changed in a characteristic fashion depending on the physiological conditions of myofibrils, suggesting that it comes from cross-bridge structures. BDM treatments significantly affected the soft radial component of contracting myofibrils depending on the approach velocity of cantilever: It was nearly equal to that in the contracting state at high approach velocity, whereas as low as that in the relaxing state at low approach velocity. However, comparable BDM treatments greatly suppressed the force production and the axial stiffness in contracting glycerinated muscle fibers and also the sliding velocity of actin filaments in the in vitro motility assay. Considering that BDM shifts the cross-bridge population from force generating to pre-force generating states in contracting muscle, the obtained results strongly suggest that cross-bridges in the pre-force generating state are visco-elastically attached to the thin filaments in such a binding manner that the axial stiffness is low but the radial stiffness significantly high similar to that in force generating state.

Psychological contract types as moderator in the breach-violation and violation-burnout relationships.

PubMed

Jamil, Amber; Raja, Usman; Darr, Wendy

2013-01-01

This research examined the relationships between perceived psychological contract breach, felt violation, and burnout in a sample (n = 361) of employees from various organizations in Pakistan. The moderating role of contract types in these relationships was also tested. Findings supported a positive association between perceived psychological contract breach and felt violation and both were positively related to burnout. Transactional and relational contracts moderated the felt violation-burnout relationship. Scores on relational contract type tended to be higher than for transactional contract type showing some contextual influence.

Earth resources-regional transfer activity contracts review

NASA Technical Reports Server (NTRS)

Bensko, J., Jr.; Daniels, J. L.; Downs, S. W., Jr.; Jones, N. L.; Morton, R. R.; Paludan, C. T.

1977-01-01

A regional transfer activity contracts review held by the Earth Resources Office was summarized. Contracts in the earth resources field primarily directed toward applications of satellite data and technology in solution of state and regional problems were reviewed. A summary of the progress of each contract was given in order to share experiences of researchers across a seven state region. The region included Missouri, Kentucky, Tennessee, Mississippi, Alabama, Georgia, and North Carolina. Research in several earth science disciplines included forestry, limnology, water resources, land use, geology, and mathematical modeling. The use of computers for establishment of information retrieval systems was also emphasized.

48 CFR 237.7300 - Scope.

Code of Federal Regulations, 2010 CFR

2010-10-01

... DEFENSE SPECIAL CATEGORIES OF CONTRACTING SERVICE CONTRACTING Services of Students at Research and... intermittent services of students at institutions of higher learning for the purpose of providing technical support at Defense research and development laboratories (10 U.S.C. 2360). ...

76 FR 21810 - Defense Federal Acquisition Regulation Supplement; Acquisition of Commercial Items (DFARS Case...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-19

... required to fully and adequately document the contract file regarding the market research performed by the... commercial determination is made before contract award. This determination is based on market research, an...

Mutuality and reciprocity in the psychological contracts of employees and employers.

PubMed

Dabos, Guillermo E; Rousseau, Denise M

2004-02-01

The authors assessed the joint perceptions of the employee and his or her employer to examine mutuality and reciprocity in the employment relationship. Paired psychological contract reports were obtained from 80 employee-employer dyads in 16 university-based research centers. On the basis of in-depth study of the research setting, research directors were identified as primary agents for the university (employer) in shaping the terms of employment of staff scientists (employees). By assessing the extent of consistency between employee and employer beliefs regarding their exchange agreement, the present study mapped the variation and consequences of mutuality and reciprocity in psychological contracts. Results indicate that both mutuality and reciprocity are positively related to archival indicators of research productivity and career advancement, in addition to self-reported measures of Met Expectations and intention to continue working with the employer. Implications for psychological contract theory are presented. ((c) 2004 APA, all rights reserved)

48 CFR 227.7103-13 - Government right to review, verify, challenge and validate asserted restrictions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... contracting officer shall not challenge a contractor's assertion that a commercial item, component, or process... to development of the item, component or process. (2) Presumption regarding development exclusively... validation of asserted restrictions for technical data related to commercial items, and to major systems, on...

48 CFR 227.7103-13 - Government right to review, verify, challenge and validate asserted restrictions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... contracting officer shall not challenge a contractor's assertion that a commercial item, component, or process... to development of the item, component or process. (2) Presumption regarding development exclusively... validation of asserted restrictions for technical data related to commercial items, and to major systems, on...

48 CFR 227.7103-13 - Government right to review, verify, challenge and validate asserted restrictions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... contracting officer shall not challenge a contractor's assertion that a commercial item, component, or process... to development of the item, component or process. (2) Presumption regarding development exclusively... validation of asserted restrictions for technical data related to commercial items, and to major systems, on...

48 CFR 227.7103-13 - Government right to review, verify, challenge and validate asserted restrictions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... contracting officer shall not challenge a contractor's assertion that a commercial item, component, or process... to development of the item, component or process. (2) Presumption regarding development exclusively... validation of asserted restrictions for technical data related to commercial items, and to major systems, on...

48 CFR 1852.219-85 - Conditions for final payment-SBIR and STTR contracts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... employment of the principal investigator (PI) identified in this SBIR contract was with the Contractor... number); and 7. For STTR contracts: The primary employment of the principal investigator (PI) identified in this STTR contract was the SBC/Contractor or the research institution (RI). The PI identified in...

48 CFR 1852.219-85 - Conditions for final payment-SBIR and STTR contracts.

Code of Federal Regulations, 2014 CFR

2014-10-01

... employment of the principal investigator (PI) identified in this SBIR contract was with the Contractor... number); and 7. For STTR contracts: The primary employment of the principal investigator (PI) identified in this STTR contract was the SBC/Contractor or the research institution (RI). The PI identified in...

48 CFR 1852.219-85 - Conditions for final payment-SBIR and STTR contracts.

Code of Federal Regulations, 2013 CFR

2013-10-01

... employment of the principal investigator (PI) identified in this SBIR contract was with the Contractor... number); and 7. For STTR contracts: The primary employment of the principal investigator (PI) identified in this STTR contract was the SBC/Contractor or the research institution (RI). The PI identified in...

48 CFR 1852.219-85 - Conditions for final payment-SBIR and STTR contracts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... employment of the principal investigator (PI) identified in this SBIR contract was with the Contractor... number); and 7. For STTR contracts: The primary employment of the principal investigator (PI) identified in this STTR contract was the SBC/Contractor or the research institution (RI). The PI identified in...

48 CFR 1852.219-85 - Conditions for final payment-SBIR and STTR contracts.

Code of Federal Regulations, 2010 CFR

2010-10-01

... employment of the principal investigator (PI) identified in this SBIR contract was with the Contractor... number); and 7. For STTR contracts: The primary employment of the principal investigator (PI) identified in this STTR contract was the SBC/Contractor or the research institution (RI). The PI identified in...

The Effects of Eccentric Contraction Duration on Muscle Strength, Power Production, Vertical Jump, and Soreness.

PubMed

Mike, Jonathan N; Cole, Nathan; Herrera, Chris; VanDusseldorp, Trisha; Kravitz, Len; Kerksick, Chad M

2017-03-01

Mike, JN, Cole, N, Herrera, C, VanDusseldorp, T, Kravitz, L, and Kerksick, CM. The effects of eccentric contraction duration on muscle strength, power production, vertical jump, and soreness. J Strength Cond Res 31(3): 773-786, 2017-Previous research has investigated the effects of either eccentric-only training or comparing eccentric and concentric exercise on changes related to strength and power expression, but no research to date has investigated the impact of altering the duration of either the concentric or the eccentric component on these parameters. Therefore, the purpose of this study was to assess the duration of eccentric (i.e., 2-second, 4-second vs. 6-second) muscle contractions and their effect on muscle strength, power production, vertical jump, and soreness using a plate-loaded barbell Smith squat exercise. Thirty college-aged men (23 ± 3.5 years, 178 ± 6.8 cm, 82 ± 12 kg, and 11.6 ± 5.1% fat) with 3.0 ± 1.0 years of resistance training experience and training frequency of 4.3 ± 0.9 days per week were randomized and assigned to 1 of 3 eccentric training groups that incorporated different patterns of contraction. For every repetition, all 3 groups used 2-second concentric contractions and paused for 1 second between the concentric and eccentric phases. The control group (2S) used 2-second eccentric contractions, whereas the 4S group performed 4-second eccentric contractions and the 6S group performed 6-second eccentric contractions. All repetitions were completed using the barbell Smith squat exercise. All participants completed a 4-week training protocol that required them to complete 2 workouts per week using their prescribed contraction routine for 4 sets of 6 repetitions at an intensity of 80-85% one repetition maximum (1RM). For all performance data, significant group × time (G × T) interaction effects were found for average power production across all 3 sets of a squat jump protocol (p = 0.04) while vertical jump did not reach significance but there was a trend toward a difference (G × T, p = 0.07). No other significant (p > 0.05) G × T interaction effects were found for the performance variables. All groups showed significant main effects for time in 1RM (p < 0.001), vertical jump (p = 0.004), peak power (p < 0.001), and average power (p < 0.001). Peak velocity data indicated that the 6S group experienced a significant reduction in peak velocity during the squat jump protocol as a result of the 4-week training program (p = 0.03). Soreness data revealed significant increases across time in all groups at both week 0 and week 4. Paired sample t-tests revealed greater differences in soreness values across time in the 2S group. The results provide further evidence that resistance training with eccentrically dominated movement patterns can be an effective method to acutely increase maximal strength and power expression in trained college age men. Furthermore, longer eccentric contractions may negatively impact explosive movements such as the vertical jump, whereas shorter eccentric contractions may instigate greater amounts of soreness. These are important considerations for the strength and conditioning professional to more fully understand that expressions of strength and power through eccentric training and varying durations of eccentric activity can have a significant impact for populations ranging from athletes desiring peak performance.

Reflections on the Human Terrain System During the First 4 Years

DTIC Science & Technology

2011-09-01

contracted social science research and analysis capability in both Iraq and Afghanistan to conduct empirical qualitative and quantita- tive...contracted social science research and analysis capability in both Iraq and Afghanistan to conduct empirical qualitative and quantita- tive research to...problematic.29 All research products in the public domain (including ethnographies produced by academic anthropologists) are accessible by intelligence

Research Interactions between Industry and Higher-Education: An Examination of the Major Legal Issues Involved in Four Representative Contracts.

ERIC Educational Resources Information Center

Reams, Bernard Dinsmore

The use of complex research agreements for joint research activities between industry and universities is assessed, with attention to the legal rights of the contracting parties. The focus is research relationships between a university and a company or an individual scientist and industry. The historical development and legal foundation of…

Pier and contraction scour prediction in cohesive soils at selected bridges in Illinois

USGS Publications Warehouse

Straub, Timothy D.; Over, Thomas M.

2010-01-01

This report presents the results of testing the Scour Rate In Cohesive Soils-Erosion Function Apparatus (SRICOS-EFA) method for estimating scour depth of cohesive soils at 15 bridges in Illinois. The SRICOS-EFA method for complex pier and contraction scour in cohesive soils has two primary components. The first component includes the calculation of the maximum contraction and pier scour (Zmax). The second component is an integrated approach that considers a time factor, soil properties, and continued interaction between the contraction and pier scour (SRICOS runs). The SRICOS-EFA results were compared to scour prediction results for non-cohesive soils based on Hydraulic Engineering Circular No. 18 (HEC-18). On average, the HEC-18 method predicted higher scour depths than the SRICOS-EFA method. A reduction factor was determined for each HEC-18 result to make it match the maximum of three types of SRICOS run results. The unconfined compressive strength (Qu) for the soil was then matched with the reduction factor and the results were ranked in order of increasing Qu. Reduction factors were then grouped by Qu and applied to each bridge site and soil. These results, and comparison with the SRICOS Zmax calculation, show that less than half of the reduction-factor method values were the lowest estimate of scour; whereas, the Zmax method values were the lowest estimate for over half. A tiered approach to predicting pier and contraction scour was developed. There are four levels to this approach numbered in order of complexity, with the fourth level being a full SRICOS-EFA analysis. Levels 1 and 2 involve the reduction factors and Zmax calculation, and can be completed without EFA data. Level 3 requires some surrogate EFA data. Levels 3 and 4 require streamflow for input into SRICOS. Estimation techniques for both EFA surrogate data and streamflow data were developed.

Multiyear Procurement (MYP) and Block Buy Contracting in Defense Acquisition: Background and Issues for Congress

DTIC Science & Technology

2016-03-23

Multiyear Procurement (MYP) and Block Buy Contracting in Defense Acquisition: Background and Issues for Congress Ronald O’Rourke Specialist...Multiyear Procurement (MYP) and Block Buy Contracting in Defense Acquisition Congressional Research Service Summary Multiyear procurement (MYP) and... block buy contracting (BBC) are special contracting mechanisms that Congress permits the Department of Defense (DOD) to use for a limited number of

Multiyear Procurement (MYP) and Block Buy Contracting in Defense Acquisition: Background and Issues for Congress

DTIC Science & Technology

2016-07-25

Multiyear Procurement (MYP) and Block Buy Contracting in Defense Acquisition: Background and Issues for Congress Ronald O’Rourke Specialist...Multiyear Procurement (MYP) and Block Buy Contracting in Defense Acquisition Congressional Research Service Summary Multiyear procurement (MYP) and... block buy contracting (BBC) are special contracting mechanisms that Congress permits the Department of Defense (DOD) to use for a limited number of

Evaluation of narrow transverse contraction joints in jointed plain concrete pavements.

DOT National Transportation Integrated Search

2006-03-01

This report presents the results of a research project conducted at the Louisiana Transportation Research Center (LTRC) to evaluate the performance of narrow transverse contraction joints to control cracking in jointed plain concrete pavements. In ad...

48 CFR 1535.007 - Solicitations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 6 2012-10-01 2012-10-01 false Solicitations. 1535.007 Section 1535.007 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1535.007 Solicitations. (a) Contracting officers...

48 CFR 1535.007 - Solicitations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Solicitations. 1535.007 Section 1535.007 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1535.007 Solicitations. (a) Contracting officers...

48 CFR 1535.007 - Solicitations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 6 2014-10-01 2014-10-01 false Solicitations. 1535.007 Section 1535.007 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1535.007 Solicitations. (a) Contracting officers...

48 CFR 1535.007 - Solicitations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Solicitations. 1535.007 Section 1535.007 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1535.007 Solicitations. (a) Contracting officers...

The effect of boric acid on acethylcholine, bethanechol and potasssium-evoked responses on ileum of rat.

PubMed

Ince, S; Turkmen, R; Yavuz, H

2011-01-01

1 The aim of this study was to clarify the effect of boric acid on contractions of rat isolated ileum. 2 Contractile responses expressed as Emax and pD2 for acetylcholine (10(-3)-10(-8) m, Ach), bethanechol (10(-3)-10(-8) m) and potassium (10-80 × 10(-3) m, KCl) were determined in the absence and presence of boric acid (10(-3); 5 × 10(-4); 10(-4) m). 3 The contractile response to Ach in the presence of verapamil (10(-6) or 10(-8) m) or in calcium-free Tyrode's solution was also determined in the absence and presence of boric acid. 4 Boric acid did not affect the contractile response to Ach, bethanechol or KCl. Single or cumulative treatment of boric acid did not affect ileum muscle contraction evoked by KCl. The atropine-resistant component of Ach-induced contraction and 4-diphenyl-acetoxy-N-methyl-piperidine methiodide-resistant component of bethanechol-induced contraction were not inhibited by boric acid (10(-3) m). The contractile response to Ach was reduced in calcium-free Tyrode's solution, and the contractile response was not affected by (10(-8) m). The addition of boric acid (10(-3) m) in combination with verapamil (10(-8) m) did not significantly affect the contractile response to Ach. 5 In conclusion, boric acid does not affect contractions induced by Ach, bethanechol or potassium in rat isolated ileum. © 2011 Blackwell Publishing Ltd.

48 CFR 252.225-7018 - Notice of prohibition of certain contracts with foreign entities for the conduct of ballistic...

Code of Federal Regulations, 2010 CFR

2010-10-01

... certain contracts with foreign entities for the conduct of ballistic missile defense research, development... foreign entities for the conduct of ballistic missile defense research, development, test, and evaluation... With Foreign Entities for the Conduct of Ballistic Missile Defense Research, Development, Test, and...

Liquid Modernity: Exploring the Research Contract Nexus within Contemporary Scottish Political Culture

ERIC Educational Resources Information Center

Holligan, Chris

2013-01-01

This paper contributes to our understanding of a supposed free-market in research, where knowledge-transfer is to government, which then brokers the evidence into professional fields. Education research contracts are put out to tender by Scottish Government and a constellation of factors constructing this phenomenon has epistemological and…

A Guide to Resources and Sources of Information for Acquisition Research

DTIC Science & Technology

1980-01-01

State, and Federal, plus the full text of all Federal cases from 1961. Public contract law decisions are included in the case files. (9) LEXIS, Mead...expensive and would be difficult to justify simply for research in public contract law . On the other hand, law schools or organizations with...reflecting a particular emphasis in the area of Government contract law . In addition to a comprehensive collection of statutes, opinions and

Guidelines for the processing and quality assurance of benthic invertebrate samples collected as part of the National Water-Quality Assessment Program

USGS Publications Warehouse

Cuffney, T.F.; Gurtz, M.E.; Meador, M.R.

1993-01-01

Benthic invertebrate samples are collected as part of the U.S. Geological Survey's National Water-Quality Assessment Program. This is a perennial, multidisciplinary program that integrates biological, physical, and chemical indicators of water quality to evaluate status and trends and to develop an understanding of the factors controlling observed water quality. The Program examines water quality in 60 study units (coupled ground- and surface-water systems) that encompass most of the conterminous United States and parts of Alaska and Hawaii. Study-unit teams collect and process qualitative and semi-quantitative invertebrate samples according to standardized procedures. These samples are processed (elutriated and subsampled) in the field to produce as many as four sample components: large-rare, main-body, elutriate, and split. Each sample component is preserved in 10-percent formalin, and two components, large-rare and main-body, are sent to contract laboratories for further processing. The large-rare component is composed of large invertebrates that are removed from the sample matrix during field processing and placed in one or more containers. The main-body sample component consists of the remaining sample materials (sediment, detritus, and invertebrates) and is subsampled in the field to achieve a volume of 750 milliliters or less. The remaining two sample components, elutriate and split, are used for quality-assurance and quality-control purposes. Contract laboratories are used to identify and quantify invertebrates from the large-rare and main-body sample components according to the procedures and guidelines specified within this document. These guidelines allow the use of subsampling techniques to reduce the volume of sample material processed and to facilitate identifications. These processing procedures and techniques may be modified if the modifications provide equal or greater levels of accuracy and precision. The intent of sample processing is to determine the quantity of each taxon present in the semi-quantitative samples or to list the taxa present in qualitative samples. The processing guidelines provide standardized laboratory forms, sample labels, detailed sample processing flow charts, standardized format for electronic data, quality-assurance procedures and checks, sample tracking standards, and target levels for taxonomic determinations. The contract laboratory (1) is responsible for identifications and quantifications, (2) constructs reference collections, (3) provides data in hard copy and electronic forms, (4) follows specified quality-assurance and quality-control procedures, and (5) returns all processed and unprocessed portions of the samples. The U.S. Geological Survey's Quality Management Group maintains a Biological Quality-Assurance Unit, located at the National Water-Quality Laboratory, Arvada, Colorado, to oversee the use of contract laboratories and ensure the quality of data obtained from these laboratories according to the guidelines established in this document. This unit establishes contract specifications, reviews contractor performance (timeliness, accuracy, and consistency), enters data into the National Water Information System-II data base, maintains in-house reference collections, deposits voucher specimens in outside museums, and interacts with taxonomic experts within and outside the U.S. Geological Survey. This unit also modifies the existing sample processing and quality-assurance guidelines, establishes criteria and testing procedures for qualifying potential contract laboratories, identifies qualified taxonomic experts, and establishes voucher collections.

Hypersonic Composites Resist Extreme Heat and Stress

NASA Technical Reports Server (NTRS)

2007-01-01

Through research contracts with NASA, Materials and Electrochemical Research Corporation (MER), of Tucson, Arizona, contributed a number of technologies to record-breaking hypersonic flights. Through this research, MER developed a coating that successfully passed testing to simulate Mach 10 conditions, as well as provide several additional carbon-carbon (C-C) composite components for the flights. MER created all of the leading edges for the X-43A test vehicles at Dryden-considered the most critical parts of this experimental craft. In addition to being very heat resistant, the coating had to be very lightweight and thin, as the aircraft was designed to very precise specifications and could not afford to have a bulky coating. MER patented its carbon-carbon (C-C) composite process and then formed a spinoff company, Frontier Materials Corporation (FMC), also based in Tucson. FMC is using the patent in conjunction with low-cost PAN (polyacrylonitrile)-based fibers to introduce these materials to the commercial markets. The C-C composites are very lightweight and exceptionally strong and stiff, even at very high temperatures. The composites have been used in industrial heating applications, the automotive and aerospace industries, as well as in glass manufacturing and on semiconductors. Applications also include transfer components for glass manufacturing and structural members for carrier support in semiconductor processing.

Ca2+-dependent rapid Ca2+ sensitization of contraction in arterial smooth muscle.

PubMed

Dimopoulos, George J; Semba, Shingo; Kitazawa, Kazuyo; Eto, Masumi; Kitazawa, Toshio

2007-01-05

Ca(2+) ion is a universal intracellular messenger that regulates numerous biological functions. In smooth muscle, Ca(2+) with calmodulin activates myosin light chain (MLC) kinase to initiate a rapid MLC phosphorylation and contraction. To test the hypothesis that regulation of MLC phosphatase is involved in the rapid development of MLC phosphorylation and contraction during Ca(2+) transient, we compared Ca(2+) signal, MLC phosphorylation, and 2 modes of inhibition of MLC phosphatase, phosphorylation of CPI-17 Thr38 and MYPT1 Thr853, during alpha(1) agonist-induced contraction with/without various inhibitors in intact rabbit femoral artery. Phenylephrine rapidly induced CPI-17 phosphorylation from a negligible amount to a peak value of 0.38+/-0.04 mol of Pi/mol within 7 seconds following stimulation, similar to the rapid time course of Ca(2+) rise and MLC phosphorylation. This rapid CPI-17 phosphorylation was dramatically inhibited by either blocking Ca(2+) release from the sarcoplasmic reticulum or by pretreatment with protein kinase C inhibitors, suggesting an involvement of Ca(2+)-dependent protein kinase C. This was followed by a slow Ca(2+)-independent and Rho-kinase/protein kinase C-dependent phosphorylation of CPI-17. In contrast, MYPT1 phosphorylation had only a slow component that increased from 0.29+/-0.09 at rest to the peak of 0.68+/-0.14 mol of Pi/mol at 1 minute, similar to the time course of contraction. Thus, there are 2 components of the Ca(2+) sensitization through inhibition of MLC phosphatase. Our results support the hypothesis that the initial rapid Ca(2+) rise induces a rapid inhibition of MLC phosphatase coincident with the Ca(2+)-induced MLC kinase activation to synergistically initiate a rapid MLC phosphorylation and contraction in arteries with abundant CPI-17 content.

Analysis of Contracting Processes, Internal Controls, and Procurement Fraud Schemes

DTIC Science & Technology

2013-06-01

Government Accountability Office (GAO) has kept DoD Contract Management on its High Risk Series list since 1992 (GAO, 2009). In addition, the GAO also...adopted from the Committee of Sponsoring Organizations of the Treadway Commission ( COSO ) (1992). There are five components: control environment, risk ...2001). 2. Risk Assessment Risk assessment is the identification, analysis, and management of risk faced by an organization. It entails identifying

Department of Defense Annual Statement of Assurance, Volume II for Fiscal Year 1996.

DTIC Science & Technology

1996-12-01

FY 1996. US Army Audit Agency (USAAA) conducted a multilocation audit of contract security requirements at the request of the US Army Contracting...corrective action(s) are certified by the responsible components upon completion and reviewed through on-site verification, subsequent audit . inspection...requirement for processing Navy pricing inquiries received by DLA inventory control points. 9/97 Verification: Subsequent on-site verification. audit

13 CFR 125.19 - When may a contracting officer set-aside a procurement for SDVO SBCs?

Code of Federal Regulations, 2011 CFR

2011-01-01

... made at fair market price. Effective Date Note: At 75 FR 62281, Oct. 7, 2010, § 125.19 was amended by... market prices. This requirement does not preclude a contracting officer from setting aside a contract... fair market prices. However, after conducting market research, the contracting officer shall first...

Extending the Work of Cowen and Fowles: A Historical Analysis of Kentucky Teacher Contracts

ERIC Educational Resources Information Center

Ingle, W. Kyle; Wisman, R. Aaron

2018-01-01

We extend the work of Cowen and Fowles by examining contracts in Kentucky school districts with collective bargaining. Using document analysis, we sought to answer the following research question: Do key provisions of teacher contracts change over time? We also examine the most recently negotiated contract in Louisville schools (2013-2018). We…

Notification: Preliminary Research on the U.S. Chemical Safety and Hazard Investigation Board's Management of Contracts

EPA Pesticide Factsheets

June 3, 2013. The U.S. Environmental Protection Agency’s Office of Inspector General plans to begin preliminary research on the U.S. Chemical Safety and Hazard Investigation Board’s management of contracts.

48 CFR 235.017-1 - Sponsoring agreements.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.017-1... Institute of Technology, and Software Engineering Institute operated by Carnegie Mellon) may respond to solicitations and announcements for programs which promote research, development, demonstration, or transfer of...

48 CFR 235.017-1 - Sponsoring agreements.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., DEPARTMENT OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 235.017-1... Institute of Technology, and Software Engineering Institute operated by Carnegie Mellon) may respond to solicitations and announcements for programs which promote research, development, demonstration, or transfer of...

NASA's university program: Active grants and research contracts, fiscal year 1975

NASA Technical Reports Server (NTRS)

1975-01-01

Active university research projects for Fiscal Year 1975 are reported by state, and foreign country. Cross indexes by: (1) grant/contract number; (2) field of science and engineering; (3) technical officer location; and (4) RTOP are included.

48 CFR 917.7301 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Policy. 917.7301 Section 917.7301 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES SPECIAL CONTRACTING METHODS Program Research and Development Announcements 917.7301 Policy. ...

75 FR 18034 - Defense Federal Acquisition Regulation Supplement; Research and Development Contract Type...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-08

... on DoD program managers and contracting personnel to justify the decision to issue a shipbuilding... reverse order when applied to shipbuilding contracts. DoD Response: For MDAPs, the procedures in DFARS 234...

48 CFR 37.202 - Exclusions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CONTRACTING SERVICE CONTRACTING Advisory and Assistance Services 37.202 Exclusions. The following activities...) Routine information technology services unless they are an integral part of a contract for the acquisition... research involving medical, biological, physical, social, psychological, or other phenomena. [60 FR 49722...

Interactive radiopharmaceutical facility between Yale Medical Center and Brookhaven National Laboratory. Progress report, October 1976-June 1979

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gottschalk, A.

1979-01-01

DOE Contract No. EY-76-S-02-4078 was started in October 1976 to set up an investigative radiochemical facility at the Yale Medical Center which would bridge the gap between current investigation with radionuclides at the Yale School of Medicine and the facilities in the Chemistry Department at the Brookhaven National Laboratory. To facilitate these goals, Dr. Mathew L. Thakur was recruited who joined the Yale University faculty in March of 1977. This report briefly summarizes our research accomplishments through the end of June 1979. These can be broadly classified into three categories: (1) research using indium-111 labelled cellular blood components; (2) developmentmore » of new radiopharmaceuticals; and (3) interaction with Dr. Alfred Wolf and colleagues in the Chemistry Department of Brookhaven National Laboratory.« less

Transfer of strength and power training to sports performance.

PubMed

Young, Warren B

2006-06-01

The purposes of this review are to identify the factors that contribute to the transference of strength and power training to sports performance and to provide resistance-training guidelines. Using sprinting performance as an example, exercises involving bilateral contractions of the leg muscles resulting in vertical movement, such as squats and jump squats, have minimal transfer to performance. However, plyometric training, including unilateral exercises and horizontal movement of the whole body, elicits significant increases in sprint acceleration performance, thus highlighting the importance of movement pattern and contraction velocity specificity. Relatively large gains in power output in nonspecific movements (intramuscular coordination) can be accompanied by small changes in sprint performance. Research on neural adaptations to resistance training indicates that intermuscular coordination is an important component in achieving transfer to sports skills. Although the specificity of resistance training is important, general strength training is potentially useful for the purposes of increasing body mass, decreasing the risk of soft-tissue injuries, and developing core stability. Hypertrophy and general power exercises can enhance sports performance, but optimal transfer from training also requires a specific exercise program.

Mechanism of the calcium-regulation of muscle contraction — In pursuit of its structural basis —

PubMed Central

WAKABAYASHI, Takeyuki

2015-01-01

The author reviewed the research that led to establish the structural basis for the mechanism of the calcium-regulation of the contraction of striated muscles. The target of calcium ions is troponin on the thin filaments, of which the main component is the double-stranded helix of actin. A model of thin filament was generated by adding tropomyosin and troponin. During the process to provide the structural evidence for the model, the troponin arm was found to protrude from the calcium-depleted troponin and binds to the carboxyl-terminal region of actin. As a result, the carboxyl-terminal region of tropomyosin shifts and covers the myosin-binding sites of actin to block the binding of myosin. At higher calcium concentrations, the troponin arm changes its partner from actin to the main body of calcium-loaded troponin. Then, tropomyosin shifts back to the position near the grooves of actin double helix, and the myosin-binding sites of actin becomes available to myosin resulting in force generation through actin-myosin interactions. PMID:26194856

Teamwork in Task Analysis. Training Manual V

DTIC Science & Technology

1975-11-01

Research Programs Psychological Sciences Division Office of Naval Research Contract No. N00014-74-A-0436-0001 NR 151-370 Approved for public...Corps (Code RD) And Monitored By Personnel and Training Research Programs Psychological Sciences Division Office of Naval Research Contract No...survival in the hidden warfare of the destructive psychological win-lose game. Win-lose behavior stems from individual attitudes and manage- ment climate

Toward a better understanding of psychological contract breach: a study of customer service employees.

PubMed

Deery, Stephen J; Iverson, Roderick D; Walsh, Janet T

2006-01-01

Experiences of psychological contract breach have been associated with a range of negative behavior. However, much of the research has focused on master of business administration alumni and managers and made use of self-reported outcomes. Studying a sample of customer service employees, the research found that psychological contract breach was related to lower organizational trust, which, in turn was associated with perceptions of less cooperative employment relations and higher levels of absenteeism. Furthermore, perceptions of external market pressures moderated the effect of psychological contract breach on absenteeism. The study indicated that psychological contract breach can arise when employees perceive discrepancies between an organization's espoused behavioral standards and its actual behavioral standards, and this can affect discretionary absence. (c) 2006 APA, all rights reserved.

Discovery of Empirical Components by Information Theory

DTIC Science & Technology

2016-08-10

AFRL-AFOSR-VA-TR-2016-0289 Discovery of Empirical Components by Information Theory Amit Singer TRUSTEES OF PRINCETON UNIVERSITY 1 NASSAU HALL...3. DATES COVERED (From - To) 15 Feb 2013 to 14 Feb 2016 5a. CONTRACT NUMBER Discovery of Empirical Components by Information Theory 5b. GRANT...they draw not only from traditional linear algebra based numerical analysis or approximation theory , but also from information theory , graph theory

[The contracting process and outsourcing in health: the scenario for dispute between public and private interests].

PubMed

Albuquerque, Maria do Socorro Veloso; Morais, Heloísa Maria Mendonça de; Lima, Luci Praciano

2015-06-01

This research analyzed the public-private composition in the municipal health network and aspects of the contracting/outsourcing process for services over the period from 2001 to 2008. The research method used was a case study with documentary research and interviews. The interviewees were former secretaries of health, directors of regulation and district managers. The categories of analysis used were public funds, care networks and public control. The results showed that the contracting was restricted to philanthropic units. With respect to the other private establishments linked to the public care network, non-compliance with programmatic aspects was detected, such as the lack of regulation of bidding processes required for contracting. Management authorities did not actively pursue building up state public services, or the formation of care networks. The contracted establishments conducted their activities without effective external and internal control mechanisms, which are paramount for the proper use of public resources. The authors conclude that the contracting process does not significantly alter the standard of buying and selling of services and indeed does not enhance the empowering process of the role of the public domain.

The effect of compound 48/80 on contractions induced by toluene diisocyanate in isolated guinea-pig bronchus.

PubMed

Mapp, C E; Boniotti, A; Papi, A; Chitano, P; Coser, E; Di Stefano, A; Saetta, M; Ciaccia, A; Fabbri, L M

1993-06-01

We have investigated the ability of compound 48/80 and of histamine H1 and H2 receptor antagonists to inhibit toluene diisocyanate-induced contractions in isolated guinea-pig bronchi. Compound 48/80 (100 micrograms/ml) significantly inhibited toluene diisocyanate-induced contractions. By contrast, the two histamine H1 and H2 receptor antagonists, chlorpheniramine (10 microM) and cimetidine, (10 microM) did not affect toluene diisocyanate-induced contractions, but significantly inhibited contractions induced by exogenously applied histamine (100 microM) and by 48/80. We investigated which mechanisms 48/80 used to inhibit toluene diisocyanate-induced contractions, paying particular attention to the possible involvement of capsaicin-sensitive primary afferents. In vitro capsaicin desensitization (10 microM for 30 min followed by washing) significantly reduced compound 48/80-induced contractions. A capsaicin-resistant component of contraction was also evident. Ruthenium red (3 microM), an inorganic dye which acts as a selective functional antagonist of capsaicin, did not affect 48/80-induced contraction. MEN 10,207 (Tyr5,D-Trp6,8,9,Arg10)-neurokinin A (4-10) (3 microM) a selective antagonist of NK2-tachykinin receptors significantly reduced 48/80-induced contractions. These results show that compound 48/80 inhibits toluene diisocyanate-induced contractions in isolated guinea-pig bronchi. It is likely that two mechanisms are involved in the inhibition: (1) the release of mediators other than histamine by mast cells, (2) an effect of 48/80 on sensory nerves.

13 CFR 127.503 - When is a contracting officer authorized to restrict competition under this part?

Code of Federal Regulations, 2010 CFR

2010-01-01

... reasonable expectation based on market research that: (1) Two or more EDWOSBs will submit offers for the... requirements. If market research indicates that the criteria in paragraph (a) are not met for restricting...; and (2) The contracting officer has a reasonable expectation based on market research that— (i) Two or...

13 CFR 127.503 - When is a contracting officer authorized to restrict competition under this part?

Code of Federal Regulations, 2011 CFR

2011-01-01

... has a reasonable expectation based on market research that: (1) Two or more EDWOSBs will submit offers...) WOSB requirements. If market research indicates that the criteria in paragraph (a) are not met for...; and (2) The contracting officer has a reasonable expectation based on market research that— (i) Two or...

A model for the electronic support of practice-based research networks.

PubMed

Peterson, Kevin A; Delaney, Brendan C; Arvanitis, Theodoros N; Taweel, Adel; Sandberg, Elisabeth A; Speedie, Stuart; Richard Hobbs, F D

2012-01-01

The principal goal of the electronic Primary Care Research Network (ePCRN) is to enable the development of an electronic infrastructure to support clinical research activities in primary care practice-based research networks (PBRNs). We describe the model that the ePCRN developed to enhance the growth and to expand the reach of PBRN research. Use cases and activity diagrams were developed from interviews with key informants from 11 PBRNs from the United States and United Kingdom. Discrete functions were identified and aggregated into logical components. Interaction diagrams were created, and an overall composite diagram was constructed describing the proposed software behavior. Software for each component was written and aggregated, and the resulting prototype application was pilot tested for feasibility. A practical model was then created by separating application activities into distinct software packages based on existing PBRN business rules, hardware requirements, network requirements, and security concerns. We present an information architecture that provides for essential interactions, activities, data flows, and structural elements necessary for providing support for PBRN translational research activities. The model describes research information exchange between investigators and clusters of independent data sites supported by a contracted research director. The model was designed to support recruitment for clinical trials, collection of aggregated anonymous data, and retrieval of identifiable data from previously consented patients across hundreds of practices. The proposed model advances our understanding of the fundamental roles and activities of PBRNs and defines the information exchange commonly used by PBRNs to successfully engage community health care clinicians in translational research activities. By describing the network architecture in a language familiar to that used by software developers, the model provides an important foundation for the development of electronic support for essential PBRN research activities.

48 CFR 1335.014 - Government property and title.

Code of Federal Regulations, 2013 CFR

2013-10-01

... to equipment purchased by nonprofit institutions of higher learning and nonprofit organizations whose primary purpose is the conduct of scientific research is set forth in CAM 1301.70. ... CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 1335.014 Government property and title. The...

30 CFR 402.13 - Program management.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 2 2012-07-01 2012-07-01 false Program management. 402.13 Section 402.13 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE... these programs. (c) Contracts. Administrative requirements for performance of research contracts will be...

30 CFR 402.13 - Program management.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 2 2014-07-01 2014-07-01 false Program management. 402.13 Section 402.13 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE... these programs. (c) Contracts. Administrative requirements for performance of research contracts will be...

30 CFR 402.13 - Program management.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Program management. 402.13 Section 402.13 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE... these programs. (c) Contracts. Administrative requirements for performance of research contracts will be...

30 CFR 402.13 - Program management.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Program management. 402.13 Section 402.13 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE... these programs. (c) Contracts. Administrative requirements for performance of research contracts will be...

30 CFR 402.13 - Program management.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 30 Mineral Resources 2 2013-07-01 2013-07-01 false Program management. 402.13 Section 402.13 Mineral Resources GEOLOGICAL SURVEY, DEPARTMENT OF THE INTERIOR WATER-RESOURCES RESEARCH PROGRAM AND THE... these programs. (c) Contracts. Administrative requirements for performance of research contracts will be...

21 CFR 516.141 - Qualified expert panels.

Code of Federal Regulations, 2012 CFR

2012-04-01

... funding from the requestor through a contract or research grant (either directly or indirectly through...), including for each the following: Name of the firm, topic/issue, amount received, date initiated. (iv) Contracts, grants, Cooperation Research and Development Agreement (CRADAs) (current or under negotiation...

21 CFR 516.141 - Qualified expert panels.

Code of Federal Regulations, 2013 CFR

2013-04-01

... funding from the requestor through a contract or research grant (either directly or indirectly through...), including for each the following: Name of the firm, topic/issue, amount received, date initiated. (iv) Contracts, grants, Cooperation Research and Development Agreement (CRADAs) (current or under negotiation...

21 CFR 516.141 - Qualified expert panels.

Code of Federal Regulations, 2014 CFR

2014-04-01

... funding from the requestor through a contract or research grant (either directly or indirectly through...), including for each the following: Name of the firm, topic/issue, amount received, date initiated. (iv) Contracts, grants, Cooperation Research and Development Agreement (CRADAs) (current or under negotiation...

Multiscale Models and Measurements of Muscle Forces

DTIC Science & Technology

2015-03-08

U.S. Army Research Office P.O. Box 12211 Research Triangle Park, NC 27709-2211 muscle contraction , molecular motors, x-ray diffraction REPORT...thick filament stretching during muscle contraction .  We have completed construction of a new apparatus for measuring simultaneous force, length and

48 CFR 2906.301 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... REQUIREMENTS Other Than Full and Open Competition 2906.301 Policy. (a) Department of Labor acquisitions must... for Administration and Management and, in the case of research and development contracts, also by the... for research and development, the contracting officer has the authority below the simplified...

48 CFR 2906.301 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... REQUIREMENTS Other Than Full and Open Competition 2906.301 Policy. (a) Department of Labor acquisitions must... for Administration and Management and, in the case of research and development contracts, also by the... for research and development, the contracting officer has the authority below the simplified...

Core stability: implications for dance injuries.

PubMed

Rickman, Ashley M; Ambegaonkar, Jatin P; Cortes, Nelson

2012-09-01

Dancers experience a high incidence of injury due to the extreme physical demands of dancing. The majority of dance injuries are chronic in nature and occur in the lower extremities and low back. Researchers have indicated decreased core stability (CS) as a risk factor for these injuries. Although decreased CS is suggested to negatively affect lower extremity joint motion and lumbar control during activity, this relationship has not been extensively discussed in previous dance literature. Understanding the relationship between CS and injury risk is important to help reduce dance injury incidence and improve performance. The purposes of this review were to discuss: 1. the core and components of CS, 2. the relationship between CS and injury, 3. CS assessment techniques, and 4. future dance CS research areas. CS is the integration of passive (non-contractile), active (contractile), and neural structures to minimize the effects of external forces and maintain stability. CS is maintained by a combination of muscle power, strength, endurance, and sensory-motor control of the lumbopelvic-hip complex. CS assessments include measuring muscle strength and power using maximal voluntary isometric and isokinetic contractions and measuring endurance using the Biering-Sorensen, plank, and lateral plank tests. Measuring sensory-motor control requires specialized equipment (e.g., balance platforms). Overall, limited research has comprehensively examined all components of CS together and their relationships to injury. Rather, previous researchers have separately examined core power, strength, endurance, or sensory-motor control. Future researchers should explore the multifactorial role of CS in reducing injury risk and enhancing performance in dancers.

The application of the psychological contract to workplace safety.

PubMed

Walker, Arlene; Hutton, Dorothy M

2006-01-01

Psychological contracts of safety are conceptualized as the beliefs of individuals about reciprocal safety obligations inferred from implicit or explicit promises. Although the literature on psychological contracts is growing, the existence of psychological contracts in relation to safety has not been established. The research sought to identify psychological contracts in the conversations of employees about safety, by demonstrating reciprocity in relation to employer and employee safety obligations. The identified safety obligations were used to develop a measure of psychological contracts of safety. The participants were 131 employees attending safety training sessions in retail and manufacturing organizations. Non-participant observation was used to collect the data during safety training sessions. Content analysis was used to analyze the data. Categories for coding were established through identification of language markers that demonstrated contingencies or other implied obligations. Direct evidence of reciprocity between employer safety obligations and employee safety obligations was found in statements from the participants demonstrating psychological contracts. A comprehensive list of perceived employer and employee safety obligations was compiled and developed into a measure of psychological contracts of safety. A small sample of 33 safety personnel was used to validate the safety obligations. CONCLUSIONS AND IMPACT ON INDUSTRY: Implications of these findings for safety and psychological contract research are discussed.

Veterans Affairs Contracting: Improved Oversight Needed for Certain Contractual Arrangements

DTIC Science & Technology

2015-07-01

Federally Funded Research and Development Center HCA Head of Contracting Activity IAA interagency agreement IDIQ indefinite-delivery indefinite...contracts reside in six different VA organizations. Each of these organizations has an individual designated as Head of Contracting Activity ( HCA ), who...properly trained, stating that HCAs shall develop and implement guidance ensuring only qualified individuals with appropriate training are assigned to

Stretch-stimulated glucose transport in skeletal muscle is regulated by Rac1.

PubMed

Sylow, Lykke; Møller, Lisbeth L V; Kleinert, Maximilian; Richter, Erik A; Jensen, Thomas E

2015-02-01

Rac1 regulates stretch-stimulated (i.e. mechanical stress) glucose transport in muscle. Actin depolymerization decreases stretch-induced glucose transport in skeletal muscle. Rac1 is a required part of the mechanical stress-component of the contraction-stimulus to glucose transport in skeletal muscle. An alternative to the canonical insulin signalling pathway for glucose transport is muscle contraction/exercise. Mechanical stress is an integrated part of the muscle contraction/relaxation cycle, and passive stretch stimulates muscle glucose transport. However, the signalling mechanism regulating stretch-stimulated glucose transport is not well understood. We recently reported that the actin cytoskeleton regulating GTPase, Rac1, was activated in mouse muscle in response to stretching. Rac1 is a regulator of contraction- and insulin-stimulated glucose transport, however, its role in stretch-stimulated glucose transport and signalling is unknown. We therefore investigated whether stretch-induced glucose transport in skeletal muscle required Rac1 and the actin cytoskeleton. We used muscle-specific inducible Rac1 knockout mice as well as pharmacological inhibitors of Rac1 and the actin cytoskeleton in isolated soleus and extensor digitorum longus muscles. In addition, the role of Rac1 in contraction-stimulated glucose transport during conditions without mechanical load on the muscles was evaluated in loosely hanging muscles and muscles in which cross-bridge formation was blocked by the myosin ATPase inhibitors BTS and Blebbistatin. Knockout as well as pharmacological inhibition of Rac1 reduced stretch-stimulated glucose transport by 30-50% in soleus and extensor digitorum longus muscle. The actin depolymerizing agent latrunculin B similarly decreased glucose transport in response to stretching by 40-50%. Rac1 inhibition reduced contraction-stimulated glucose transport by 30-40% in tension developing muscle but did not affect contraction-stimulated glucose transport in muscles in which force development was prevented. Our findings suggest that Rac1 and the actin cytoskeleton regulate stretch-stimulated glucose transport and that Rac1 is a required part of the mechanical stress-component of the contraction-stimulus to glucose transport in skeletal muscle. © 2014 The Authors. The Journal of Physiology © 2014 The Physiological Society.

Stretch-stimulated glucose transport in skeletal muscle is regulated by Rac1

PubMed Central

Sylow, Lykke; Møller, Lisbeth L V; Kleinert, Maximilian; Richter, Erik A; Jensen, Thomas E

2015-01-01

An alternative to the canonical insulin signalling pathway for glucose transport is muscle contraction/exercise. Mechanical stress is an integrated part of the muscle contraction/relaxation cycle, and passive stretch stimulates muscle glucose transport. However, the signalling mechanism regulating stretch-stimulated glucose transport is not well understood. We recently reported that the actin cytoskeleton regulating GTPase, Rac1, was activated in mouse muscle in response to stretching. Rac1 is a regulator of contraction- and insulin-stimulated glucose transport, however, its role in stretch-stimulated glucose transport and signalling is unknown. We therefore investigated whether stretch-induced glucose transport in skeletal muscle required Rac1 and the actin cytoskeleton. We used muscle-specific inducible Rac1 knockout mice as well as pharmacological inhibitors of Rac1 and the actin cytoskeleton in isolated soleus and extensor digitorum longus muscles. In addition, the role of Rac1 in contraction-stimulated glucose transport during conditions without mechanical load on the muscles was evaluated in loosely hanging muscles and muscles in which cross-bridge formation was blocked by the myosin ATPase inhibitors BTS and Blebbistatin. Knockout as well as pharmacological inhibition of Rac1 reduced stretch-stimulated glucose transport by 30–50% in soleus and extensor digitorum longus muscle. The actin depolymerizing agent latrunculin B similarly decreased glucose transport in response to stretching by 40–50%. Rac1 inhibition reduced contraction-stimulated glucose transport by 30–40% in tension developing muscle but did not affect contraction-stimulated glucose transport in muscles in which force development was prevented. Our findings suggest that Rac1 and the actin cytoskeleton regulate stretch-stimulated glucose transport and that Rac1 is a required part of the mechanical stress-component of the contraction-stimulus to glucose transport in skeletal muscle. Key points Rac1 regulates stretch-stimulated (i.e. mechanical stress) glucose transport in muscle. Actin depolymerization decreases stretch-induced glucose transport in skeletal muscle. Rac1 is a required part of the mechanical stress-component of the contraction-stimulus to glucose transport in skeletal muscle. PMID:25416624

An Assessment of Factors that Affect the Employment of Alternative Dispute Resolution Techniques to Resolve Contract Disputes

DTIC Science & Technology

1994-09-01

Robert Strasser, professors of Contract Law at AFIT, who offered expertise, guidance and resources that were instrumental for successful completion of...users (SAF/GC, AFRT Contract Law Department, ACUS, several law firms, and senior contracting, legal 18 and engineering professionals from the Air Force...survey for format and design. The two other research advisors, ADR and Contract Law course professors at AFIT, primarily reviewed the survey for content

Prostate Cancer Research Training Program

DTIC Science & Technology

2017-09-01

Award Number: W81XWH-16-1-0549 TITLE: Prostate Cancer Research Training Program PRINCIPAL INVESTIGATOR: David M. Lubaroff, PhD CONTRACTING...ORGANIZATION: University of Iowa Iowa City, IA 52242 REPORT DATE: September 2017 TYPE OF REPORT: Annual PREPARED FOR: U.S. Army Medical Research ...Prostate Cancer Research Training Program 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-16-1-0549 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S

48 CFR 35.009 - Subcontracting research and development effort.

Code of Federal Regulations, 2011 CFR

2011-10-01

... the best scientific and technological sources, it is important that the contractor not subcontract technical or scientific work without the contracting officer's advance knowledge. During the negotiation of a cost-reimbursement R&D contract, the contracting officer shall obtain complete information...

48 CFR 35.010 - Scientific and technical reports.

Code of Federal Regulations, 2011 CFR

2011-10-01

... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.010 Scientific and technical reports. (a) R&D contracts shall require contractors to furnish scientific and technical reports... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Scientific and technical...

48 CFR 35.010 - Scientific and technical reports.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.010 Scientific and technical reports. (a) R&D contracts shall require contractors to furnish scientific and technical reports... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Scientific and technical...

48 CFR 1827.409 - Solicitation provisions and contract clauses. (NASA supplements paragraph (a), (b), (c), (d), (e...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 52.227-14, Rights in Data—General, except in solicitations and contracts for basic or applied research with universities or colleges. (i) The contract officer shall modify the clause at FAR 52.227-17...

48 CFR 27.303 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

...)(1) Insert a patent rights clause in all solicitations and contracts for experimental, developmental... contracts for construction work or architect-engineer services that include— (i) Experimental, developmental, or research work; (ii) Test and evaluation studies; or (iii) The design of a Government facility that...

48 CFR 27.303 - Contract clauses.

Code of Federal Regulations, 2013 CFR

2013-10-01

...)(1) Insert a patent rights clause in all solicitations and contracts for experimental, developmental... contracts for construction work or architect-engineer services that include— (i) Experimental, developmental, or research work; (ii) Test and evaluation studies; or (iii) The design of a Government facility that...

48 CFR 27.303 - Contract clauses.

Code of Federal Regulations, 2014 CFR

2014-10-01

...)(1) Insert a patent rights clause in all solicitations and contracts for experimental, developmental... contracts for construction work or architect-engineer services that include— (i) Experimental, developmental, or research work; (ii) Test and evaluation studies; or (iii) The design of a Government facility that...

48 CFR 27.303 - Contract clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

...)(1) Insert a patent rights clause in all solicitations and contracts for experimental, developmental... contracts for construction work or architect-engineer services that include— (i) Experimental, developmental, or research work; (ii) Test and evaluation studies; or (iii) The design of a Government facility that...

48 CFR 35.010 - Scientific and technical reports.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Scientific and technical... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.010 Scientific and technical reports. (a) R&D contracts shall require contractors to furnish scientific and technical reports...

48 CFR 35.010 - Scientific and technical reports.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Scientific and technical... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.010 Scientific and technical reports. (a) R&D contracts shall require contractors to furnish scientific and technical reports...

48 CFR 35.010 - Scientific and technical reports.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Scientific and technical... SPECIAL CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 35.010 Scientific and technical reports. (a) R&D contracts shall require contractors to furnish scientific and technical reports...

Age 60 study, part IV : experimental evaluation of pilot performance.

DOT National Transportation Integrated Search

1994-10-01

This document is one of four products completed as a part of the Age 60 Rule Research Contract monitored by Pam Della Rocco, Civil Aerospace Medical Institute. This report was a deliverable from the research contract with Hilton Systems, Inc. on the ...

48 CFR 1352.235-73 - Research involving human subjects-after initial contract award.

Code of Federal Regulations, 2010 CFR

2010-10-01

... identifiable private information. The term “research” means a systematic investigation, including research... established a relationship with an appropriate Institutional Review Board (“cognizant IRB”). An appropriate... appropriate documentation to the Contracting Officer for Government institutional review and approval. This...

41 CFR 109-25.109 - Laboratory and research equipment.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Laboratory and research equipment. 109-25.109 Section 109-25.109 Public Contracts and Property Management Federal Property Management Regulations System (Continued) DEPARTMENT OF ENERGY PROPERTY MANAGEMENT REGULATIONS SUPPLY AND...

Initiating and Managing University-Based International Research and Development Activities.

ERIC Educational Resources Information Center

Peterson, Marla P.

1987-01-01

Initiating and managing international research and development are discussed, including: basic principles for participation in international development activities; AID and World Bank project cycles; AID and World Bank contracting modes and instruments; and international contract negotiations. Some reference sources are appended. (MLW)

An Investigation into the Nature of Non-Voiding Contractions Resulting from Detrusor Hyperreflexia in Neurogenic Bladders Following Spinal Cord Injury

DTIC Science & Technology

2013-10-01

voiding contractions (NVC) during normal bladder filling. These NVC are responsible for incontinence episodes, bladder and bladder neck damage, as...eliminated, however, voiding occurred by a combination of augmented overflow incontinence (NVC-driven and a vesicosomatic reflex of the hindquarters...spinal micturition reflex, but rather an augmented overflow incontinence with a locomotor component (High amplitude pressure swings in bottom trace

Defense Small Business Innovation Research Program (SBIR). Volume 3. Air Force Abstracts of Phase 1 Awards from FY 1988 SBIR Solicitation

DTIC Science & Technology

1989-05-01

THE TARGET DOPPLER FREQUENCIES. ADAPTIVE SENSORS INC 216 PICO BLVD - STE 8 SANTA MONICA, CA 90405 CONTRACT NUMBER: JOHN S BAILEY TITLE: SPATIALLY...APPLIED RESEARCH ASSOCS INC 4300 SAN MATEO BLVD NE - STE A220 ALBUQUERQUE, NM 87110 CONTRACT NUMBER: FRANK A MAESTAS TITLE: PARAMETRIC ANALYSIS OF EXPLOSIVE...VERIFIED THROUGH SUBSCALE FABRICATION AND TEST. AV DYNAMICS INC 825 MYRTLE AVE MONROVIA, CA 91016 CONTRACT NUMBER: DR P B S LISSAMAN TITLE: LIGHT WEIGHT

Animal electricity, Ca2+ and muscle contraction. A brief history of muscle research.

PubMed

Martonosi, A N

2000-01-01

This brief review attempts to summarize some of the major phases of muscle research from Leeuwenhoek's description of sarcomeres in 1674, through Galvani's observation of "animal electricity" in 1791, to the discovery of Ca2+ as the key messenger in the coupling of nerve excitation to muscle contraction. The emerging molecular mechanism of the contraction process is one of the great achievements of biology, reflecting the intimate links between physics, chemistry and the life Sciences in the solution of biological problems.

Chloride channel blockers promote relaxation of TEA-induced contraction in airway smooth muscle.

PubMed

Yim, Peter D; Gallos, George; Perez-Zoghbi, Jose F; Trice, Jacquelyn; Zhang, Yi; Siviski, Matthew; Sonett, Joshua; Emala, Charles W

2013-01-01

Enhanced airway smooth muscle (ASM) contraction is an important component in the pathophysiology of asthma. We have shown that ligand gated chloride channels modulate ASM contractile tone during the maintenance phase of an induced contraction, however the role of chloride flux in depolarization-induced contraction remains incompletely understood. To better understand the role of chloride flux under these conditions, muscle force (human ASM, guinea pig ASM), peripheral small airway luminal area (rat ASM) and airway smooth muscle plasma membrane electrical potentials (human cultured ASM) were measured. We found ex vivo guinea pig airway rings, human ASM strips and small peripheral airways in rat lungs slices relaxed in response to niflumic acid following depolarization-induced contraction induced by K(+) channel blockade with tetraethylammonium chloride (TEA). In isolated human airway smooth muscle cells TEA induce depolarization as measured by a fluorescent indicator or whole cell patch clamp and this depolarization was reversed by niflumic acid. These findings demonstrate that ASM depolarization induced contraction is dependent on chloride channel activity. Targeting of chloride channels may be a novel approach to relax hypercontractile airway smooth muscle in bronchoconstrictive disorders.

Contract Funding Opportunities Available for Innovative SBIR Development | Office of Cancer Clinical Proteomics Research

Cancer.gov

Does your small business need early-stage financing to take its cancer research to the next level? The National Cancer Institute Small Business Innovation Research (NCI SBIR) Development Center has released $5 million for new contract funding opportunities to support cancer research and technology development in key emerging areas of need. The NCI SBIR can help you finance and advance innovations in cancer prevention, diagnosis, treatment, and basic research.

Contracting with the Enemy: The Contracting Officer’s Dilemma

DTIC Science & Technology

2015-06-01

Acquisition Research Program Graduate School of Business & Public Policy Naval Postgraduate School NPS-CM-15-133 ACQUISITION RESEARCH PROGRAM...Thesis Advisors: Dr. Max Kidalov, Assistant Professor E. Cory Yoder, Senior Lecturer Graduate School of Business & Public Policy Naval Postgraduate...Program Graduate School of Business & Public Policy Naval Postgraduate School The research presented in this report was supported by the Acquisition

Final Closeout Report University Research Program in Robotics for Environmental Restoration and Waste Management

DOE Office of Scientific and Technical Information (OSTI.GOV)

James S. Tulenko; Carl Crane

2004-08-24

The report covers the 2003-04 contract period, with a retrospective of the 11 years for the contract, from 1993 to 2004. This includes personnel, technical publications and reports, plus research laboratories employed. Specific information is given in eight research areas, reporting on all technology developed and/or deployed by the University of Florida.

Volcanic Plumes on Io and Mars

NASA Technical Reports Server (NTRS)

Glaze, Lori S.; Senske, David (Technical Monitor)

2001-01-01

Proxemy research is under contract to NASA to perform science research of volcanic plumes on Mars and Io. This report is submitted in accordance with contract NASW-00013 and contains a summary of activities. In addition to a synopsis of science research conducted, any manuscripts submitted for publication in this time period are also attached. Abstracts to scientific conferences may also be included if appropriate.

Comparison of Analytical Predictions and Experimental Results for a Dual Brayton Power System

NASA Technical Reports Server (NTRS)

Johnson, Paul

2007-01-01

NASA Glenn Research Center (GRC) contracted Barber- Nichols, Arvada, CO to construct a dual Brayton power conversion system for use as a hardware proof of concept and to validate results from a computational code known as the Closed Cycle System Simulation (CCSS). Initial checkout tests were performed at Barber- Nichols to ready the system for delivery to GRC. This presentation describes the system hardware components and lists the types of checkout tests performed along with a couple issues encountered while conducting the tests. A description of the CCSS model is also presented. The checkout tests did not focus on generating data, therefore, no test data or model analyses are presented.