Contextual herd factors associated with cow culling risk in Québec dairy herds: A multilevel analysis.

PubMed

Haine, Denis; Delgado, Hector; Cue, Roger; Sewalem, Asheber; Wade, Kevin; Lacroix, René; Lefebvre, Daniel; Arsenault, Julie; Bouchard, Émile; Dubuc, Jocelyn

2017-09-01

Several health disorders, such as milk fever, displaced abomasum, and mastitis, as well as impaired reproductive performance, are known risk factors for the removal of affected cows from a dairy herd. While cow-level risk factors are well documented in the literature, herd-level associations have been less frequently investigated. The objective of this study was to investigate the effect of cow- and herd-level determinants on variations in culling risk in Québec dairy herds: whether herd influences a cow's culling risk. For this, we assessed the influence of herd membership on cow culling risk according to displaced abomasum, milk fever, and retained placenta. A retrospective longitudinal study was conducted on data from dairy herds in the Province of Québec, Canada, by extracting health information events from the dairy herd health management software used by most Québec dairy producers and their veterinarians. Data were extracted for all lactations starting between January 1st and December 31st, 2010. Using multilevel logistic regression, we analysed a total of 10,529 cows from 201 herds that met the inclusion criteria. Milk fever and displaced abomasum were demonstrated to increase the cow culling risk. A minor general herd effect was found for the culling risk (i.e. an intra-class correlation of 1.0% and median odds ratio [MOR] of 1.20). The proportion of first lactation cows was responsible for this significant, but weak herd effect on individual cow culling risk, after taking into account the cow-level factors. On the other hand, the herd's average milk production was a protective factor. The planning and management of forthcoming replacement animals has to be taken into consideration when assessing cow culling risks and herd culling rates. Copyright © 2017 Elsevier B.V. All rights reserved.

Efficient generation of biliary epithelial cells from rabbit intrahepatic bile duct by Y-27632 and Matrigel.

PubMed

Jin, Lifang; Ji, Shaohui; Sun, Aijing

2013-06-01

Efficient culture of primary biliary epithelial cells (BECs) from adult liver is useful for both experimental studies and clinical applications of tissue engineering. However, an effective culture system for long-term proliferation of adult BECs is still unachieved. Laboratory rabbit has been used in a large number of studies; however, there are no reports of BECs from normal adult rabbit. As little as 5 g of normal rabbit liver tissue were minced, digested, and then clonally cultured in medium containing FBS and ITS. Cells were characterized by cell morphology, immunoassaying, and growth rate assay. Different combination of growth factors and substrates, including Y-27632 and Matrigel, were employed to assess their effect on cell proliferation. In the primary culture, the BECs cellular sheets consisting of cuboidal cells, as well as fibroblast-like cells and other hepatic cells, emerged with time of culture. The BECs cellular sheets were then manually split into cells clumps for further characterization. The subcultured cells had typical cell morphology of cholangiocytes, expressed the specific markers of BECs, including GGT, cytokeratin (CK18), and CK19, and possessed the capacity to form duct-like structure in three-dimensional Matrigel. Y-27632 and Matrigel-treated BECs had a steady growth rate as well as colony-formation capacity. The BECs were maintained in Y-27632 and Matrigel culture system for more than 3 mo. This is the first example, to our knowledge, of the successful culture of BECs from normal adult rabbit liver. Furthermore, our results indicate that treatment of BECs with Y-27632 and Matrigel is a simple method for efficient output of BECs.

Natural killer cells regulate T cell immune responses in primary biliary cirrhosis.

PubMed

Shimoda, Shinji; Hisamoto, Satomi; Harada, Kenichi; Iwasaka, Sho; Chong, Yong; Nakamura, Minoru; Bekki, Yuki; Yoshizumi, Tomoharu; Shirabe, Ken; Ikegami, Toru; Maehara, Yoshihiko; He, Xiao-Song; Gershwin, M Eric; Akashi, Koichi

2015-12-01

The hallmark of primary biliary cirrhosis (PBC) is the presence of autoreactive T- and B-cell responses that target biliary epithelial cells (BECs). Biliary cell cytotoxicity is dependent upon initiation of innate immune responses followed by chronic adaptive, as well as bystander, mechanisms. Critical to these mechanisms are interactions between natural killer (NK) cells and BECs. We have taken advantage of the ability to isolate relatively pure viable preparations of liver-derived NK cells, BECs, and endothelial cells, and studied interactions between NK cells and BECs and focused on the mechanisms that activate autoreactive T cells, their dependence on interferon (IFN)-γ, and expression of BEC major histocompatibility complex (MHC) class I and II molecules. Here we show that at a high NK/BEC ratio, NK cells are cytotoxic for autologous BECs, but are not dependent on autoantigen, yet still activate autoreactive CD4(+) T cells in the presence of antigen presenting cells. In contrast, at a low NK/BEC ratio, BECs are not lysed, but IFN-γ production is induced, which facilitates expression of MHC class I and II molecules on BEC and protects them from lysis upon subsequent exposure to autoreactive NK cells. Furthermore, IFN-γ secreted from NK cells after exposure to autologous BECs is essential for this protective function and enables autoreactive CD4(+) T cells to become cytopathic. NK cell-mediated innate immune responses are likely critical at the initial stage of PBC, but also facilitate and maintain the chronic cytopathic effect of autoantigen-specific T cells, essential for progression of disease. © 2015 by the American Association for the Study of Liver Diseases.

REVERSETRANSCIPTION-PCR ASSAYS FOR THE DETECTION OF BOVINE ENTERIC CALICIVIRUSES (BEC) AND ANALYSIS OF THE GENETIC RELATIONSHIPS AMONG BEC AND HUMAN CALICIVIRUSES

EPA Science Inventory

Two genetically distinct bovine enteric caliciviruses (BEC) have been identified: the Norwalk-like-viruses (NLV), which are genetically related to human NLV, and the distinct NB-like BEC, which is most closely related to Sapporo-like viruses and lagoviruses, but potentially may ...

Analyses of Third Order Bose-Einstein Correlation by Means of Coulomb Wave Function

DOE Office of Scientific and Technical Information (OSTI.GOV)

Biyajima, Minoru; Mizoguchi, Takuya; Suzuki, Naomichi

2006-04-11

In order to include a correction by the Coulomb interaction in Bose-Einstein correlation (BEC), the wave function for the Coulomb scattering were introduced in the quantum optical approach to BEC in the previous work. If we formulate the amplitude written by Coulomb wave functions according to the diagram for BEC in the plane wave formulation, the formula for 3{pi} -BEC becomes simpler than that of our previous work. We re-analyze the raw data of 3{pi} -BEC by NA44 and STAR Collaborations by this formula. Results are compared with the previous ones.

Effects of Methylenedianiline on Tight Junction Permeability of Biliary Epithelial Cells in vivo and in vitro

PubMed Central

Santa Cruz, Vicente; Liu, Hanlin; Kaphalia, Lata; Kanz, Mary F.

2007-01-01

Methylenedianiline (DAPM) is considered a cholangiodestructive toxicant in vivo. Increases in biliary inorganic phosphate (Pi) and glucose occur prior to biliary epithelial cell (BEC) injury, which could be due to increased paracellular permeability and/or impairment of Pi and glucose uptake by BEC. To evaluate these possibilities, we induced mild injury [loss of BEC from major bile ducts (6 h), ultrastructural alterations in BEC mitochondria and Golgi cisternae (3 h), and striking increases in biliary Pi and glucose (3–6 h)] with 25 mg DAPM/kg and then assessed temporal alterations in tight junction (TJ) permeability by measuring bile to plasma (B:P) ratios of [3H]-inulin. Parameters maintained by hepatocytes in bile were unchanged (bile flow, bile acids, bilirubin) or only transiently perturbed (protein, glutathione). Minimal elevations in B:P ratios of inulin occurred temporally later (4 h) in DAPM-treated rats than increases in biliary Pi and glucose. To confirm a direct effect of DAPM on BEC TJs, we measured transepithelial resistance (TER) and bi-ionic potentials of BEC monolayers prior to and after exposure to pooled (4 to 6) bile samples collected from untreated rats (Basal Bile) or rats treated with 50 mg DAPM/ kg (DAPM-Bile). BEC TJs were found to be cation selective. Exposure to DAPM-Bile for 1 h decreased TERs by ~35% and decreased charge selectivity of BEC TJs while exposure to Basal Bile had no effects. These observations indicate that DAPM-Bile impairs paracellular permeability of BEC in vitro. Further, our in vivo model suggests that increases in paracellular permeability induced by DAPM are localized to BEC because bile flow and constituents excreted by hepatocytes were unchanged; BEC damage was temporally correlated with increases in biliary Pi and glucose; and elevations in B:P ratios of inulin were delayed and minimal. PMID:17178199

Preterm birth in the Inuit and First Nations populations of Québec, Canada, 1981-2008.

PubMed

Auger, Nathalie; Fon Sing, Mélanie; Park, Alison L; Lo, Ernest; Trempe, Normand; Luo, Zhong-Cheng

2012-03-24

To evaluate preterm birth (PTB) for Inuit and First Nations vs. non-Indigenous populations in the province of Québec, Canada. Retrospective cohort study. We evaluated singleton live births for Québec residents, 1981-2008 (n = 2,310,466). Municipality of residence (Inuit-inhabited, First Nations-inhabited, rest of Québec) and language (Inuit, First Nations, French/English) were used to identify Inuit and First Nations births. The outcome was PTB (<37 completed weeks). Cox proportional hazards regression was employed to estimate hazard ratios (HR) and 95% confidence intervals (CI) of PTB, adjusting for maternal age, education, marital status, parity and birth year. PTB rates were higher for Inuit language speakers in Inuit-inhabited areas and the rest of Québec compared with French/English speakers in the rest of Québec, and disparities persisted over time. Relative to French/English speakers in the rest of Québec, Inuit language speakers in the rest of Québec had the highest risk of PTB (HR 1.98, 95% CI: 1.62-2.41). The risk was also elevated for Inuit language speakers in Inuit-inhabited areas, though to a lesser extent (HR 1.29, 95% CI: 1.18-1.41). In contrast, First Nations language speakers in First Nations-inhabited areas and the rest of Québec had similar or lower risks of PTB relative to French/English speakers in the rest of Québec. Inuit populations, especially those outside Inuit-inhabited areas, have persistently elevated risks of PTB, indicating a need for strategies to prevent PTB in this population.

Preterm birth in the Inuit and First Nations populations of Québec, Canada, 1981–2008

PubMed Central

Auger, Nathalie; Sing, Mélanie Fon; Park, Alison L.; Lo, Ernest; Trempe, Normand; Luo, Zhong-Cheng

2012-01-01

Objectives To evaluate preterm birth (PTB) for Inuit and First Nations vs. non-Indigenous populations in the province of Québec, Canada. Study design Retrospective cohort study. Methods We evaluated singleton live births for Québec residents, 1981–2008 (n =2,310,466). Municipality of residence (Inuit-inhabited, First Nations-inhabited, rest of Québec) and language (Inuit, First Nations, French/English) were used to identify Inuit and First Nations births. The outcome was PTB (<37 completed weeks). Cox proportional hazards regression was employed to estimate hazard ratios (HR) and 95% confidence intervals (CI) of PTB, adjusting for maternal age, education, marital status, parity and birth year. Results PTB rates were higher for Inuit language speakers in Inuit-inhabited areas and the rest of Québec compared with French/English speakers in the rest of Québec, and disparities persisted over time. Relative to French/English speakers in the rest of Québec, Inuit language speakers in the rest of Québec had the highest risk of PTB (HR 1.98, 95% CI: 1.62–2.41). The risk was also elevated for Inuit language speakers in Inuit-inhabited areas, though to a lesser extent (HR 1.29, 95% CI: 1.18–1.41). In contrast, First Nations language speakers in First Nations-inhabited areas and the rest of Québec had similar or lower risks of PTB relative to French/English speakers in the rest of Québec. Conclusions Inuit populations, especially those outside Inuit-inhabited areas, have persistently elevated risks of PTB, indicating a need for strategies to prevent PTB in this population. PMID:22456035

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kira, M., E-mail: mackillo.kira@physik.uni-marburg.de

Atomic Bose–Einstein condensates (BECs) can be viewed as macroscopic objects where atoms form correlated atom clusters to all orders. Therefore, the presence of a BEC makes the direct use of the cluster-expansion approach–lucrative e.g. in semiconductor quantum optics–inefficient when solving the many-body kinetics of a strongly interacting Bose. An excitation picture is introduced with a nonunitary transformation that describes the system in terms of atom clusters within the normal component alone. The nontrivial properties of this transformation are systematically studied, which yields a cluster-expansion friendly formalism for a strongly interacting Bose gas. Its connections and corrections to the standard Hartree–Fock–Bogoliubov approachmore » are discussed and the role of the order parameter and the Bogoliubov excitations are identified. The resulting interaction effects are shown to visibly modify number fluctuations of the BEC. Even when the BEC has a nearly perfect second-order coherence, the BEC number fluctuations can still resolve interaction-generated non-Poissonian fluctuations. - Highlights: • Excitation picture expresses interacting Bose gas with few atom clusters. • Semiconductor and BEC many-body investigations are connected with cluster expansion. • Quantum statistics of BEC is identified in terms of atom clusters. • BEC number fluctuations show extreme sensitivity to many-body correlations. • Cluster-expansion friendly framework is established for an interacting Bose gas.« less

The development and preliminary validation of the behavior, environment, and changeability survey (BECS).

PubMed

Walsh, Jennifer R; Hebert, Angel; Byrd-Bredbenner, Carol; Carey, Gale; Colby, Sarah; Brown-Esters, Onikia N; Greene, Geoffrey; Hoerr, Sharon; Horacek, Tanya; Kattelmann, Kendra; Kidd, Tandalayo; Koenings, Mallory; Phillips, Beatrice; Shelnutt, Karla P; White, Adrienne A

2012-01-01

To develop and test the validity of the Behavior, Environment, and Changeability Survey (BECS) for identifying the importance and changeability of nutrition, exercise, and stress management behavior and related aspects of the environment. A cross-sectional, online survey of the BECS and selected validated instruments. Ten state universities. A convenience sample of college students (n = 1,283), ages 18-24 years. Principal component analysis was used to confirm a 6-component structure of the BECS in 2 independent samples for the purpose of cross-validation. Internal consistency was measured and construct and criterion-related analyses were conducted to test the reliability and validity of the BECS subscales. Six components representing 34 BECS items were revealed from the original 69 items and explained 64% of the total variance. Six scales were retained, and internal consistency of each ranged from α = .82 to .93. BECS Nutrition Behavior and Nutrition Changeability scale scores were highest for participants in action/maintenance Stages of Change for fruit and vegetable intake. There is strong support for the use of the BECS when planning health programs to gain insight into behavior that young adults are willing to improve, specifically related to nutrition, exercise, and sleep. Copyright © 2012 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

From polariton condensates to highly photonic quantum degenerate states of bosonic matter

PubMed Central

Aßmann, Marc; Tempel, Jean-Sebastian; Veit, Franziska; Bayer, Manfred; Rahimi-Iman, Arash; Löffler, Andreas; Höfling, Sven; Reitzenstein, Stephan; Worschech, Lukas; Forchel, Alfred

2011-01-01

Bose–Einstein condensation (BEC) is a thermodynamic phase transition of an interacting Bose gas. Its key signatures are remarkable quantum effects like superfluidity and a phonon-like Bogoliubov excitation spectrum, which have been verified for atomic BECs. In the solid state, BEC of exciton–polaritons has been reported. Polaritons are strongly coupled light-matter quasiparticles in semiconductor microcavities and composite bosons. However, they are subject to dephasing and decay and need external pumping to reach a steady state. Accordingly the polariton BEC is a nonequilibrium process of a degenerate polariton gas in self-equilibrium, but out of equilibrium with the baths it is coupled to and therefore deviates from the thermodynamic phase transition seen in atomic BECs. Here we show that key signatures of BEC can even be observed without fulfilling the self-equilibrium condition in a highly photonic quantum degenerate nonequilibrium system. PMID:21245353

CrossTalk: The Journal of Defense Software Engineering. Volume 19, Number 4

DTIC Science & Technology

2006-04-01

by each task order organization; however, an ACA is only a piece of paper that asks a contrac- tor to play nice. To help socialize the ACAs, the...facu l t y. e rau .edu/kor n/ papers / ESREL04KorneckiZalewski.pdf>. 7. Lougee, H. “DO-178B Certified Soft- ware: A Formal Reuse Analysis Ap- proach...Québec à Montréal as an industrial researcher, and is a member of the International Electronics and En- gineers. He has published more than 10 papers in

Computations of M sub 2 and K sub 1 ocean tidal perturbations in satellite elements

NASA Technical Reports Server (NTRS)

Estes, R. H.

1974-01-01

Semi-analytic perturbation equations for the influence of M2 and K1 ocean tidal constituents on satellite motion are expanded into multi-dimensional Fourier series and calculations made for the BE-C satellite. Perturbation in the orbital elements are compared to those of the long period solid earth tides.

Development and application of a multiplex PCR assay for detection of the Clostridium perfringens enterotoxin-encoding genes cpe and becAB.

PubMed

Yonogi, Shinya; Kanki, Masashi; Ohnishi, Takahiro; Shiono, Masami; Iida, Tetsuya; Kumeda, Yuko

2016-08-01

Clostridium perfringens causes food-borne gastroenteritis following the consumption of contaminated food by producing C. perfringens enterotoxin (CPE) in the intestines. Recently, we reported a novel enterotoxin, binary enterotoxin of C. perfringens (BEC) in C. perfringens isolates, which caused two disease outbreaks in Japan. Consequently, in the event of food poisoning outbreaks caused by C. perfringens, it is now necessary to screen for both the cpe and becAB genes by diagnostic PCR. Here, we present a simple multiplex PCR method for simultaneous detection of cpe, becAB and a C. perfringens control locus, phospholipase C (plc). Applying this method, we investigated the prevalence of cpe- or becAB-carrying C. perfringens strains in human stool and bovine rectum swab samples. Using a total of 169 isolates, we found that the percentage of becAB-carrying strains was very small (0.59%), one-tenth that of cpe-carrying strains. The simple method presented in this study with high specificity and sensitivity to C. perfringens will be a useful tool to survey the global prevalence of becAB-carrying C. perfringens strains. Copyright © 2016 Elsevier B.V. All rights reserved.

Dispersive shock waves in Bose-Einstein condensates and nonlinear nano-oscillators in ferromagnetic thin films

NASA Astrophysics Data System (ADS)

Hoefer, Mark A.

This thesis examines nonlinear wave phenomena, in two physical systems: a Bose-Einstein condensate (BEC) and thin film ferromagnets where the magnetization dynamics are excited by the spin momentum transfer (SMT) effect. In the first system, shock waves generated by steep gradients in the BEC wavefunction are shown to be of the disperse type. Asymptotic and averaging methods are used to determine shock speeds and structure in one spatial dimension. These results are compared with multidimensional numerical simulations and experiment showing good, qualitative agreement. In the second system, a model of magnetization dynamics due to SMT is presented. Using this model, nonlinear oscillating modes---nano-oscillators---are found numerically and analytically using perturbative methods. These results compare well with experiment. A Bose-Einstein condensate (BEC) is a quantum fluid that gives rise to interesting shock wave nonlinear dynamics. Experiments depict a BEC that exhibits behavior similar to that of a shock wave in a compressible gas, e.g. traveling fronts with steep gradients. However, the governing Gross-Pitaevskii (GP) equation that describes the mean field of a BEC admits no dissipation hence classical dissipative shock solutions do not explain the phenomena. Instead, wave dynamics with small dispersion is considered and it is shown that this provides a mechanism for the generation of a dispersive shock wave (DSW). Computations with the GP equation are compared to experiment with excellent agreement. A comparison between a canonical 1D dissipative and dispersive shock problem shows significant differences in shock structure and shock front speed. Numerical results associated with laboratory experiments show that three and two-dimensional approximations are in excellent agreement and one dimensional approximations are in qualitative agreement. The interaction of two DSWs is investigated analytically and numerically. Using one dimensional DSW theory it is argued that the experimentally observed blast waves may be viewed as dispersive shock waves. A nonlinear mathematical model of spin-wave excitation using a point contact in a thin ferromagnetic film is introduced. This work incorporates a recently proposed spin-torque contribution to classical magnetodynamic theory with a variable coefficient terra in the magnetic torque equation. Large-amplitude magnetic solitary waves are computed, which help explain recent spin-torque experiments. Numerical simulations of the full nonlinear model predict excitation frequencies in excess of 0.2 THz for contact diameters smaller than 6 nm. Simulations also predict a saturation and red shift of the frequency at currents large enough to invert the magnetization tinder the point contact. In the weak nonlinear limit, the theory is approximated by a cubic complex Ginzburg-Landau type equation. The mode's nonlinear frequency shift is found by use of perturbation techniques, whose results agree with those of direct numerical simulations.

Fast machine-learning online optimization of ultra-cold-atom experiments.

PubMed

Wigley, P B; Everitt, P J; van den Hengel, A; Bastian, J W; Sooriyabandara, M A; McDonald, G D; Hardman, K S; Quinlivan, C D; Manju, P; Kuhn, C C N; Petersen, I R; Luiten, A N; Hope, J J; Robins, N P; Hush, M R

2016-05-16

We apply an online optimization process based on machine learning to the production of Bose-Einstein condensates (BEC). BEC is typically created with an exponential evaporation ramp that is optimal for ergodic dynamics with two-body s-wave interactions and no other loss rates, but likely sub-optimal for real experiments. Through repeated machine-controlled scientific experimentation and observations our 'learner' discovers an optimal evaporation ramp for BEC production. In contrast to previous work, our learner uses a Gaussian process to develop a statistical model of the relationship between the parameters it controls and the quality of the BEC produced. We demonstrate that the Gaussian process machine learner is able to discover a ramp that produces high quality BECs in 10 times fewer iterations than a previously used online optimization technique. Furthermore, we show the internal model developed can be used to determine which parameters are essential in BEC creation and which are unimportant, providing insight into the optimization process of the system.

Fast machine-learning online optimization of ultra-cold-atom experiments

PubMed Central

Wigley, P. B.; Everitt, P. J.; van den Hengel, A.; Bastian, J. W.; Sooriyabandara, M. A.; McDonald, G. D.; Hardman, K. S.; Quinlivan, C. D.; Manju, P.; Kuhn, C. C. N.; Petersen, I. R.; Luiten, A. N.; Hope, J. J.; Robins, N. P.; Hush, M. R.

2016-01-01

We apply an online optimization process based on machine learning to the production of Bose-Einstein condensates (BEC). BEC is typically created with an exponential evaporation ramp that is optimal for ergodic dynamics with two-body s-wave interactions and no other loss rates, but likely sub-optimal for real experiments. Through repeated machine-controlled scientific experimentation and observations our ‘learner’ discovers an optimal evaporation ramp for BEC production. In contrast to previous work, our learner uses a Gaussian process to develop a statistical model of the relationship between the parameters it controls and the quality of the BEC produced. We demonstrate that the Gaussian process machine learner is able to discover a ramp that produces high quality BECs in 10 times fewer iterations than a previously used online optimization technique. Furthermore, we show the internal model developed can be used to determine which parameters are essential in BEC creation and which are unimportant, providing insight into the optimization process of the system. PMID:27180805

Magnon condensation and spin superfluidity

NASA Astrophysics Data System (ADS)

Bunkov, Yury M.; Safonov, Vladimir L.

2018-04-01

We consider the Bose-Einstein condensation (BEC) of quasi-equilibrium magnons which leads to spin superfluidity, the coherent quantum transfer of magnetization in magnetic material. The critical conditions for excited magnon density in ferro- and antiferromagnets, bulk and thin films, are estimated and discussed. It was demonstrated that only the highly populated region of the spectrum is responsible for the emergence of any BEC. This finding substantially simplifies the BEC theoretical analysis and is surely to be used for simulations. It is shown that the conditions of magnon BEC in the perpendicular magnetized YIG thin film is fulfillied at small angle, when signals are treated as excited spin waves. We also predict that the magnon BEC should occur in the antiferromagnetic hematite at room temperature at much lower excited magnon density compared to that of ferromagnetic YIG. Bogoliubov's theory of Bose-Einstein condensate is generalized to the case of multi-particle interactions. The six-magnon repulsive interaction may be responsible for the BEC stability in ferro- and antiferromagnets where the four-magnon interaction is attractive.

Collision of impurities with Bose–Einstein condensates

NASA Astrophysics Data System (ADS)

Lingua, F.; Lepori, L.; Minardi, F.; Penna, V.; Salasnich, L.

2018-04-01

Quantum dynamics of impurities in a bath of bosons is a long-standing problem in solid-state, plasma, and atomic physics. Recent experimental and theoretical investigations with ultracold atoms have focused on this problem, studying atomic impurities immersed in an atomic Bose–Einstein condensate (BEC) and for various relative coupling strengths tuned by the Fano‑Feshbach resonance technique. Here, we report extensive numerical simulations on a closely related problem: the collision between a bosonic impurity consisting of a few 41K atoms and a BEC of 87Rb atoms in a quasi one-dimensional configuration and under a weak harmonic axial confinement. For small values of the inter-species interaction strength (regardless of its sign), we find that the impurity, which starts from outside the BEC, simply causes the BEC cloud to oscillate back and forth, but the frequency of oscillation depends on the interaction strength. For intermediate couplings, after a few cycles of oscillation the impurity is captured by the BEC, and strongly changes its amplitude of oscillation. In the strong interaction regime, if the inter-species interaction is attractive, a local maximum (bright soliton) in the BEC density occurs where the impurity is trapped; if, instead, the inter-species interaction is repulsive, the impurity is not able to enter the BEC cloud and the reflection coefficient is close to one. However, if the initial displacement of the impurity is increased, the impurity is able to penetrate the cloud, leading to the appearance of a moving hole (dark soliton) in the BEC.

Quantum fluctuations in the BCS-BEC crossover of two-dimensional Fermi gases

DOE Office of Scientific and Technical Information (OSTI.GOV)

He, Lianyi; Lu, Haifeng; Cao, Gaoqing

2015-08-14

We present a theoretical study of the ground state of the BCS-BEC crossover in dilute two-dimensional Fermi gases. While the mean-field theory provides a simple and analytical equation of state, the pressure is equal to that of a noninteracting Fermi gas in the entire BCS-BEC crossover, which is not consistent with the features of a weakly interacting Bose condensate in the BEC limit and a weakly interacting Fermi liquid in the BCS limit. The inadequacy of the two-dimensional mean-field theory indicates that the quantum fluctuations are much more pronounced than those in three dimensions. In this work, we show thatmore » the inclusion of the Gaussian quantum fluctuations naturally recovers the above features in both the BEC and the BCS limits. In the BEC limit, the missing logarithmic dependence on the boson chemical potential is recovered by the quantum fluctuations. Near the quantum phase transition from the vacuum to the BEC phase, we compare our equation of state with the known grand canonical equation of state of two-dimensional Bose gases and determine the ratio of the composite boson scattering length a B to the fermion scattering length a 2D. We find a B ≃ 0.56a 2D, in good agreement with the exact four-body calculation. As a result, we compare our equation of state in the BCS-BEC crossover with recent results from the quantum Monte Carlo simulations and the experimental measurements and find good agreements.« less

COMPARISON OF PM-INDUCED GENE EXPRESSION PROFILES BETWEEN BRONCHIAL EPITHELIAL CELLS AND NASAL EPITHELIAL CELLS IN HUMAN

EPA Science Inventory

Epidemiologic studies have linked exposures to particulate matter (PM) and increased pulmonary mortality and morbidity. Bronchial epithelial cells (BEC) are the primary target of PM. PM exposure induces a wide array of biological responses in BEC. Primary human BEC, however, need...

Influence of silicon oxide on the performance of TiN bottom electrode in phase change memory

NASA Astrophysics Data System (ADS)

Gao, Dan; Liu, Bo; Xu, Zhen; Wang, Heng; Xia, Yangyang; Wang, Lei; Zhu, Nanfei; Li, Ying; Zhan, Yipeng; Song, Zhitang; Feng, Songlin

2016-10-01

The stability of TiN which is the preferred bottom electrode contact (BEC) of phase change memory (PCM) due to its low thermal conductivity and suitable electrical conductivity, is very essential to the reliability of PCM devices. In this work, in order to investigate the effect of high aspect ratio process (HARP) SiO2 on the performance of TiN, both TiN/SiO2, TiN/SiN thin films and TiN BEC device structures are analyzed. By combining transmission electron microscopy (TEM) and energy dispersive X-ray spectroscopy (EDS), we found that the TiN would be oxidized after the deposition of HARP SiO2 and there exist a thin ( 4 nm) oxidation interfacial layer between TiN and SiO2. Electrical measurements were performed on the 1R PCM test-key die with 7 nm and 10 nm BEC-only cells. The statistical initial resistances of BEC have wide distribution and it is confirmed that the non-uniform oxidation of TiN BEC affects the astringency of the resistance of TiN BEC. The experimental results help to optimize the process of TiN BEC, and SiN is recommended as a better choice as the linear layer.

The Development and Preliminary Validation of the Behavior, Environment, and Changeability Survey (BECS)

ERIC Educational Resources Information Center

Walsh, Jennifer R.; Hebert, Angel; Byrd-Bredbenner, Carol; Carey, Gale; Colby, Sarah; Brown-Esters, Onikia N.; Greene, Geoffrey; Hoerr, Sharon; Horacek, Tanya; Kattelmann, Kendra; Kidd, Tandalayo; Koenings, Mallory; Phillips, Beatrice; Shelnutt, Karla P.; White, Adrienne A.

2012-01-01

Objective: To develop and test the validity of the Behavior, Environment, and Changeability Survey (BECS) for identifying the importance and changeability of nutrition, exercise, and stress management behavior and related aspects of the environment. Design: A cross-sectional, online survey of the BECS and selected validated instruments. Setting:…

77 FR 13676 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-07

... Alberta Investment Management Corporation, Caisse de d[eacute]p[ocirc]t et placement du Qu[eacute]bec... Capital Markets Inc., Fonds de solidarit[eacute] des travailleurs du Qu[eacute]bec (F.T.Q.), GMP Capital... (Qu[eacute]bec), Alberta Securities Commission, British Columbia Securities Commission, Competition...

Bose-Einstein Condensates in 1D Optical Lattices: Nonlinearity and Wannier-Stark Spectra

NASA Astrophysics Data System (ADS)

Arimondo, Ennio; Ciampini, Donatella; Morsch, Oliver

The development of powerful laser cooling and trapping techniques has made possible the controlled realization of dense and cold gaseous samples, thus opening the way for investigations in the ultracold temperature regimes not accessible with conventional techniques. A Bose-Einstein condensate (BEC) represents a peculiar gaseous state where all the particles reside in the same quantum mechanical state. Therefore BECs exhibit quantum mechanical phe-nomena on a macroscopic scale with a single quantum mechanical wavefunction describing the external degrees of freedom. That control of the external degrees of freedom is combined with a precise control of the internal degrees. The BEC investigation has become a very active area of research in contem-porary physics. The BEC study encompasses different subfields of physics, i.e., atomic and molecular physics, quantum optics, laser spectroscopy, solid state physics. Atomic physics and laser spectroscopy provide the methods for creating and manipulating the atomic and molecular BECs. However owing to the interactions between the particles composing the condensate and to the configuration of the external potential, concepts and methods from solid state physics are extensively used for BEC description.

Collective excitation frequencies and stationary states of trapped dipolar Bose-Einstein condensates in the Thomas-Fermi regime

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bijnen, R. M. W. van; Department of Physics and Astronomy, McMaster University, Hamilton, Ontario L8S 4M1; Parker, N. G.

We present a general method for obtaining the exact static solutions and collective excitation frequencies of a trapped Bose-Einstein condensate (BEC) with dipolar atomic interactions in the Thomas-Fermi regime. The method incorporates analytic expressions for the dipolar potential of an arbitrary polynomial density profile, thereby reducing the problem of handling nonlocal dipolar interactions to the solution of algebraic equations. We comprehensively map out the static solutions and excitation modes, including non-cylindrically-symmetric traps, and also the case of negative scattering length where dipolar interactions stabilize an otherwise unstable condensate. The dynamical stability of the excitation modes gives insight into the onsetmore » of collapse of a dipolar BEC. We find that global collapse is consistently mediated by an anisotropic quadrupolar collective mode, although there are two trapping regimes in which the BEC is stable against quadrupole fluctuations even as the ratio of the dipolar to s-wave interactions becomes infinite. Motivated by the possibility of a fragmented condensate in a dipolar Bose gas due to the partially attractive interactions, we pay special attention to the scissors modes, which can provide a signature of superfluidity, and identify a long-range restoring force which is peculiar to dipolar systems. As part of the supporting material for this paper we provide the computer program used to make the calculations, including a graphical user interface.« less

Hidden multiparticle excitation in a weakly interacting Bose-Einstein condensate

NASA Astrophysics Data System (ADS)

Watabe, Shohei

2018-03-01

We investigate multiparticle excitation effect on a collective density excitation as well as a single-particle excitation in a weakly interacting Bose-Einstein condensate (BEC). We find that although the weakly interacting BEC offers weak multiparticle excitation spectrum at low temperatures, this multiparticle excitation effect may not remain hidden, but emerges as bimodality in the density response function through the single-particle excitation. Identification of spectra in the BEC between the single-particle excitation and the density excitation is also assessed at nonzero temperatures, which has been known to be unique nature in the BEC at absolute zero temperature.

Cooling of a Bose-Einstein Condensate by Spin Distillation.

PubMed

Naylor, B; Maréchal, E; Huckans, J; Gorceix, O; Pedri, P; Vernac, L; Laburthe-Tolra, B

2015-12-11

We propose and experimentally demonstrate a new cooling mechanism leading to purification of a Bose-Einstein condensate (BEC). Our scheme starts with a BEC polarized in the lowest energy spin state. Spin excited states are thermally populated by lowering the single particle energy gap set by the magnetic field. Then, these spin-excited thermal components are filtered out, which leads to an increase of the BEC fraction. We experimentally demonstrate such cooling for a spin 3 ^{52}Cr dipolar BEC. Our scheme should be applicable to Na or Rb, with the perspective to reach temperatures below 1 nK.

Proceedings of the 2012 Annual Meeting of the Canadian Mathematics Education Study Group = Actes De La Rencontre Annuelle 2012 Du Groupe Canadien D'étude en Didactique Des Mathématiques (36th, Québec City, Québec, Canada, May 25-29, 2012)

ERIC Educational Resources Information Center

Oesterle, Susan, Ed.; Allan, Darien, Ed.; Liljedahl, Peter, Ed.

2013-01-01

This submission contains the Proceedings of the 2012 Annual Meeting of the Canadian Mathematics Education Study Group (CMESG), held at Laval University in Québec City, Québec. The CMESG is a group of mathematicians and mathematics educators who meet annually to discuss mathematics education issues at all levels of learning. The aims of the Study…

Numerical simulation code for self-gravitating Bose-Einstein condensates

NASA Astrophysics Data System (ADS)

Madarassy, Enikő J. M.; Toth, Viktor T.

2013-04-01

We completed the development of simulation code that is designed to study the behavior of a conjectured dark matter galactic halo that is in the form of a Bose-Einstein Condensate (BEC). The BEC is described by the Gross-Pitaevskii equation, which can be solved numerically using the Crank-Nicholson method. The gravitational potential, in turn, is described by Poisson’s equation, that can be solved using the relaxation method. Our code combines these two methods to study the time evolution of a self-gravitating BEC. The inefficiency of the relaxation method is balanced by the fact that in subsequent time iterations, previously computed values of the gravitational field serve as very good initial estimates. The code is robust (as evidenced by its stability on coarse grids) and efficient enough to simulate the evolution of a system over the course of 109 years using a finer (100×100×100) spatial grid, in less than a day of processor time on a contemporary desktop computer. Catalogue identifier: AEOR_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEOR_v1_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 5248 No. of bytes in distributed program, including test data, etc.: 715402 Distribution format: tar.gz Programming language: C++ or FORTRAN. Computer: PCs or workstations. Operating system: Linux or Windows. Classification: 1.5. Nature of problem: Simulation of a self-gravitating Bose-Einstein condensate by simultaneous solution of the Gross-Pitaevskii and Poisson equations in three dimensions. Solution method: The Gross-Pitaevskii equation is solved numerically using the Crank-Nicholson method; Poisson’s equation is solved using the relaxation method. The time evolution of the system is governed by the Gross-Pitaevskii equation; the solution of Poisson’s equation at each time step is used as an initial estimate for the next time step, which dramatically increases the efficiency of the relaxation method. Running time: Depends on the chosen size of the problem. On a typical personal computer, a 100×100×100 grid can be solved with a time span of 10 Gyr in approx. a day of running time.

Educational Reevaluation, Political Transformation: Québec and Higher Education

ERIC Educational Resources Information Center

Unger, Zoe

2013-01-01

This paper considers the history of Québec's higher education system and the reforms that have contributed to the role of education in the province. Québec's education system has repeatedly been a site for social and political transformation; most recently, reevaluation of education's role in the province has revealed a tension between…

Beclometasone oral--DOR BioPharma.

PubMed

2007-01-01

orBec is an oral enteric-coated tablet formulation of the corticosteroid beclometasone, which has been developed by Enteron Pharmaceuticals, a subsidiary of Corporate Technology Development (now DOR BioPharma). orBec is being developed for the treatment of gastrointestinal graft-versus-host disease (GVHD) and an NDA has been filed in the US. DOR BioPharma has also filed an MAA in Europe for the same indication.orBec is designed to reduce the need for systemic immunosuppressive drugs, thereby improving the outcome of bone marrow and stem cell transplantation.DOR BioPharma may seek a marketing partner in the US and elsewhere for orBec in GVHD and will seek a partner for other potential indications of the drug.In December 2001, Corporate Technology Development was acquired by Endorex Corporation (now DOR BioPharma). In October 1998, Enteron Pharmaceuticals (DOR BioPharma) entered into an exclusive, worldwide, royalty bearing license agreement with George B. McDonald, MD, including the right to grant sublicenses, for the rights to the intellectual property and know-how relating to orBec. In January 2007, DOR BioPharma received $US3 million under a non-binding letter of intent from Sigma-Tau Pharmaceuticals. The agreement grants Sigma-Tau an exclusive right to negotiate terms and conditions for a possible business transaction or strategic alliance regarding orBec and potentially other DOR pipeline compounds until 1 March 2007. Under the terms of the agreement, Sigma-Tau purchased $US1 million of DOR's common stock, with an additional $US2 million paid in cash. If no agreement is reached by 1 March 2007, DOR will return the $US2 million to Sigma-Tau within 60 days. DOR BioPharma received an unsolicited proposal from Cell Therapeutics, Inc. to acquire DOR BioPharma in January 2007. Because of the non-binding agreement already signed with Sigma-Tau, DOR BioPharma's board of directors cannot consider Cell Therapeutics' merger proposal at this time. orBec has been filed for approval in the US for the treatment of gastrointestinal GVHD. The US FDA accepted the NDA filing and has established a target date of 21 July 2007 for completion of review of the NDA. In November 2006, the EMEA determined that the MAA for orBec for the treatment of gastrointestinal GVHD is complete and that the review process has begun. The data provided in the MAA and NDA submissions demonstrate that orBec safely provides a lower risk of mortality compared with the current standard of care. Both filings are supported by data from two randomised, double-blinded, placebo-controlled clinical trials. The first was a 129-patient pivotal phase III clinical trial for orBec conducted at 16 bone marrow/stem cell transplant centres in the US and France. The second trial was a 60-patient phase II clinical trial conducted at the Fred Hutchinson Cancer Research Centre. In the primary endpoint of its pivotal trial, time to treatment failure through day 50, orBec failed to achieve statistical significance (p-value 0.1177). However, orBec did achieve statistical significance in the secondary endpoints of time to treatment failure through day 80, and a reduction in mortality compared with placebo. In this trial, patient survival at the prespecified endpoint of 200 days post-transplant showed a statistically significant 66% reduction in mortality among patients randomised to orBec. DOR BioPharma believes the primary endpoint was not achieved due to a higher than expected rate of treatment failures during the initial 10 days in both treatment groups. The mortality benefit in favour of orBec was confirmed in a retrospective analysis of the phase II study, in which there was a 55% reduction in mortality at 200 days post-transplant. At 1 year after randomisation, there were relatively consistent 51% and 45% reductions in the risk of mortality among patients randomised to orBec in both the phase III and phase II studies, respectively.DOR BioPharma is also conducting a phase II clinical trial to investigate orBec in the prevention of gastrointestinal GVHD. DOR BioPharma has executed an exclusive licence agreement with the University of Texas Medical Branch at Galveston for the use of oral luminally active anti-inflammatory drugs, such as orBec, for the treatment of irritable bowel syndrome.

Bromodomain and extraterminal (BET) proteins regulate biliary-driven liver regeneration.

PubMed

Ko, Sungjin; Choi, Tae-Young; Russell, Jacquelyn O; So, Juhoon; Monga, Satdarshan P S; Shin, Donghun

2016-02-01

During liver regeneration, hepatocytes are derived from pre-existing hepatocytes. However, if hepatocyte proliferation is compromised, biliary epithelial cells (BECs) become the source of new hepatocytes. We recently reported on a zebrafish liver regeneration model in which BECs extensively contribute to hepatocytes. Using this model, we performed a targeted chemical screen to identify important factors that regulate BEC-driven liver regeneration, the mechanisms of which remain largely unknown. Using Tg(fabp10a:CFP-NTR) zebrafish, we examined the effects of 44 selected compounds on BEC-driven liver regeneration. Liver size was assessed by fabp10a:DsRed expression; liver marker expression was analyzed by immunostaining, in situ hybridization and quantitative PCR. Proliferation and apoptosis were also examined. Moreover, we used a mouse liver injury model, choline-deficient, ethionine-supplemented (CDE) diet. We identified 10 compounds that affected regenerating liver size. Among them, only bromodomain and extraterminal domain (BET) inhibitors, JQ1 and iBET151, blocked both Prox1 and Hnf4a induction in BECs. BET inhibition during hepatocyte ablation blocked BEC dedifferentiation into hepatoblast-like cells (HB-LCs). Intriguingly, after JQ1 washout, liver regeneration resumed, indicating temporal, but not permanent, perturbation of liver regeneration by BET inhibition. BET inhibition after hepatocyte ablation suppressed the proliferation of newly generated hepatocytes and delayed hepatocyte maturation. Importantly, Myca overexpression, in part, rescued the proliferation defect. Furthermore, oval cell numbers in mice fed CDE diet were greatly reduced upon JQ1 administration, supporting the zebrafish findings. BET proteins regulate BEC-driven liver regeneration at multiple steps: BEC dedifferentiation, HB-LC proliferation, the proliferation of newly generated hepatocytes, and hepatocyte maturation. Copyright © 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

Enhanced innate immune responsiveness and intolerance to intestinal endotoxins in human biliary epithelial cells contributes to chronic cholangitis.

PubMed

Mueller, Tobias; Beutler, Claudia; Picó, Almudena Hurtado; Shibolet, Oren; Pratt, Daniel S; Pascher, Andreas; Neuhaus, Peter; Wiedenmann, Bertram; Berg, Thomas; Podolsky, Daniel K

2011-11-01

Pattern recognition receptors (PRRs) orchestrate the innate immune defence in human biliary epithelial cells (BECs). Tight control of PRR signalling provides tolerance to physiological amounts of intestinal endotoxins in human bile to avoid constant innate immune activation in BECs. We wanted to determine whether inappropriate innate immune responses to intestinal endotoxins contribute to the development and perpetuation of chronic biliary inflammation. We examined PRR-mediated innate immune responses and protective endotoxin tolerance in primary BECs isolated from patients with primary sclerosing cholangitis (PSC), alcoholic liver disease and patients without chronic liver disease. Expression studies comprised northern blots, RT-PCR, Western blots and immunocytochemistry. Functional studies comprised immuno-precipitation Western blots, FACS for endotoxin uptake, and NF-κB activation assays and ELISA for secreted IL-8 and tumour necrosis factor (TNF)-α. Primary BECs from explanted PSC livers showed reversibly increased TLR and NOD protein expression and activation of the MyD88/IRAK signalling complex. Consecutively, PSC BECs exhibited inappropriate innate immune responses to endotoxins and did not develop immune tolerance after repeated endotoxin exposures. This endotoxin hyper-responsiveness was probably because of the stimulatory effect of abundantly expressed IFN-γ and TNF-α in PSC livers, which stimulated TLR4-mediated endotoxin signalling in BECs, leading to increased TLR4-mediated endotoxin incorporation and impaired inactivation of the TLR4 signalling cascade. As TNF-α inhibition partly restored protective innate immune tolerance, endogenous TNF-α secretion probably contributed to inappropriate endotoxin responses in BECs. Inappropriate innate immune responses to intestinal endotoxins and subsequent endotoxin intolerance because of enhanced PRR signalling in BECs probably contribute to chronic cholangitis. © 2011 John Wiley & Sons A/S.

Assessment of the diagnostic performance and interobserver variability of endocytoscopy in Barrett’s esophagus: A pilot ex-vivo study

PubMed Central

Tomizawa, Yutaka; Iyer, Prasad G; Wongkeesong, Louis M; Buttar, Navtej S; Lutzke, Lori S; Wu, Tsung-Teh; Wang, Kenneth K

2013-01-01

AIM: To investigate a classification of endocytoscopy (ECS) images in Barrett’s esophagus (BE) and evaluate its diagnostic performance and interobserver variability. METHODS: ECS was applied to surveillance endoscopic mucosal resection (EMR) specimens of BE ex-vivo. The mucosal surface of specimen was stained with 1% methylene blue and surveyed with a catheter-type endocytoscope. We selected still images that were most representative of the endoscopically suspect lesion and matched with the final histopathological diagnosis to accomplish accurate correlation. The diagnostic performance and inter-observer variability of the new classification scheme were assessed in a blinded fashion by physicians with expertise in both BE and ECS and inexperienced physicians with no prior exposure to ECS. RESULTS: Three staff physicians and 22 gastroenterology fellows classified eight randomly assigned unknown still ECS pictures (two images per each classification) into one of four histopathologic categories as follows: (1) BEC1-squamous epithelium; (2) BEC2-BE without dysplasia; (3) BEC3-BE with dysplasia; and (4) BEC4-esophageal adenocarcinoma (EAC) in BE. Accuracy of diagnosis in staff physicians and clinical fellows were, respectively, 100% and 99.4% for BEC1, 95.8% and 83.0% for BEC2, 91.7% and 83.0% for BEC3, and 95.8% and 98.3% for BEC4. Interobserver agreement of the faculty physicians and fellows in classifying each category were 0.932 and 0.897, respectively. CONCLUSION: This is the first study to investigate classification system of ECS in BE. This ex-vivo pilot study demonstrated acceptable diagnostic accuracy and excellent interobserver agreement. PMID:24379583

Inflationary Quasiparticle Creation and Thermalization Dynamics in Coupled Bose-Einstein Condensates

NASA Astrophysics Data System (ADS)

Posazhennikova, Anna; Trujillo-Martinez, Mauricio; Kroha, Johann

2016-06-01

A Bose gas in a double-well potential, exhibiting a true Bose-Einstein condensate (BEC) amplitude and initially performing Josephson oscillations, is a prototype of an isolated, nonequilibrium many-body system. We investigate the quasiparticle (QP) creation and thermalization dynamics of this system by solving the time-dependent Keldysh-Bogoliubov equations. We find avalanchelike QP creation due to a parametric resonance between BEC and QP oscillations, followed by slow, exponential relaxation to a thermal state at an elevated temperature, controlled by the initial excitation energy of the oscillating BEC above its ground state. The crossover between the two regimes occurs because of an effective decoupling of the QP and BEC oscillations. This dynamics is analogous to elementary particle creation in models of the early universe. The thermalization in our setup occurs because the BEC acts as a grand canonical reservoir for the quasiparticle system.

Coherent quantum depletion of an interacting atom condensate

PubMed Central

Kira, M.

2015-01-01

Sufficiently strong interactions promote coherent quantum transitions in spite of thermalization and losses, which are the adversaries of delicate effects such as reversibility and correlations. In atomic Bose–Einstein condensates (BECs), strong atom–atom interactions can eject atoms from the BEC to the normal component, yielding quantum depletion instead of temperature depletion. A recent experiment has already been verified to overcome losses. Here I show that it also achieves coherent quantum-depletion dynamics in a BEC swept fast enough from weak to strong atom–atom interactions. The elementary coherent process first excites the normal component into a liquid state that evolves into a spherical shell state, where the atom occupation peaks at a finite momentum to shield 50% of the BEC atoms from annihilation. The identified coherent processes resemble ultrafast semiconductor excitations expanding the scope of BEC explorations to many-body non-equilibrium studies. PMID:25767044

Inflationary Quasiparticle Creation and Thermalization Dynamics in Coupled Bose-Einstein Condensates.

PubMed

Posazhennikova, Anna; Trujillo-Martinez, Mauricio; Kroha, Johann

2016-06-03

A Bose gas in a double-well potential, exhibiting a true Bose-Einstein condensate (BEC) amplitude and initially performing Josephson oscillations, is a prototype of an isolated, nonequilibrium many-body system. We investigate the quasiparticle (QP) creation and thermalization dynamics of this system by solving the time-dependent Keldysh-Bogoliubov equations. We find avalanchelike QP creation due to a parametric resonance between BEC and QP oscillations, followed by slow, exponential relaxation to a thermal state at an elevated temperature, controlled by the initial excitation energy of the oscillating BEC above its ground state. The crossover between the two regimes occurs because of an effective decoupling of the QP and BEC oscillations. This dynamics is analogous to elementary particle creation in models of the early universe. The thermalization in our setup occurs because the BEC acts as a grand canonical reservoir for the quasiparticle system.

[Towards Professionalization : the Editorial Discourse of Québec Pharmacy magazine, 1960-2013 ].

PubMed

Savard, Pierre-André; Meunier-Sirois, Alexandre; Marando, Nancy; Bussières, Jean-François

2016-12-01

The second half of the twentieth century and the beginning of the 2000s marked deep changes in the practice of pharmacy in Quebec. The editorials of Québec Pharmacie journal attest these changes on a 50-year period by relating power relationships, conflicts, problems and solutions that concerned pharmacists. This article proposes to analyze the editorial discourse of Québec Pharmacie journal between 1960 and 2013, and to grasp the evolution of the speech. To do so, we analyze the major topics addressed by the editorialists. It appears that Québec Pharmacie’s editorialists aimed the professionalization of pharmacy.

A Machine Learning Ensemble Classifier for Early Prediction of Diabetic Retinopathy.

PubMed

S K, Somasundaram; P, Alli

2017-11-09

The main complication of diabetes is Diabetic retinopathy (DR), retinal vascular disease and it leads to the blindness. Regular screening for early DR disease detection is considered as an intensive labor and resource oriented task. Therefore, automatic detection of DR diseases is performed only by using the computational technique is the great solution. An automatic method is more reliable to determine the presence of an abnormality in Fundus images (FI) but, the classification process is poorly performed. Recently, few research works have been designed for analyzing texture discrimination capacity in FI to distinguish the healthy images. However, the feature extraction (FE) process was not performed well, due to the high dimensionality. Therefore, to identify retinal features for DR disease diagnosis and early detection using Machine Learning and Ensemble Classification method, called, Machine Learning Bagging Ensemble Classifier (ML-BEC) is designed. The ML-BEC method comprises of two stages. The first stage in ML-BEC method comprises extraction of the candidate objects from Retinal Images (RI). The candidate objects or the features for DR disease diagnosis include blood vessels, optic nerve, neural tissue, neuroretinal rim, optic disc size, thickness and variance. These features are initially extracted by applying Machine Learning technique called, t-distributed Stochastic Neighbor Embedding (t-SNE). Besides, t-SNE generates a probability distribution across high-dimensional images where the images are separated into similar and dissimilar pairs. Then, t-SNE describes a similar probability distribution across the points in the low-dimensional map. This lessens the Kullback-Leibler divergence among two distributions regarding the locations of the points on the map. The second stage comprises of application of ensemble classifiers to the extracted features for providing accurate analysis of digital FI using machine learning. In this stage, an automatic detection of DR screening system using Bagging Ensemble Classifier (BEC) is investigated. With the help of voting the process in ML-BEC, bagging minimizes the error due to variance of the base classifier. With the publicly available retinal image databases, our classifier is trained with 25% of RI. Results show that the ensemble classifier can achieve better classification accuracy (CA) than single classification models. Empirical experiments suggest that the machine learning-based ensemble classifier is efficient for further reducing DR classification time (CT).

Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish.

PubMed

Choi, Tae-Young; Ninov, Nikolay; Stainier, Didier Y R; Shin, Donghun

2014-03-01

Biliary epithelial cells (BECs) are considered to be a source of regenerating hepatocytes when hepatocyte proliferation is compromised. However, there is still controversy about the extent to which BECs can contribute to the regenerating hepatocyte population, and thereby to liver recovery. To investigate this issue, we established a zebrafish model of liver regeneration in which the extent of hepatocyte ablation can be controlled. Hepatocytes were depleted by administration of metronidazole to Tg(fabp10a:CFP-NTR) animals. We traced the origin of regenerating hepatocytes using short-term lineage-tracing experiments, as well as the inducible Cre/loxP system; specifically, we utilized both a BEC tracer line Tg(Tp1:CreER(T2)) and a hepatocyte tracer line Tg(fabp10a:CreER(T2)). We also examined BEC and hepatocyte proliferation and liver marker gene expression during liver regeneration. BECs gave rise to most of the regenerating hepatocytes in larval and adult zebrafish after severe hepatocyte depletion. After hepatocyte loss, BECs proliferated as they dedifferentiated into hepatoblast-like cells; they subsequently differentiated into highly proliferative hepatocytes that restored the liver mass. This process was impaired in zebrafish wnt2bb mutants; in these animals, hepatocytes regenerated but their proliferation was greatly reduced. BECs contribute to regenerating hepatocytes after substantial hepatocyte depletion in zebrafish, thereby leading to recovery from severe liver damage. Copyright © 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.

Estimating the number of human cases of ceftiofur-resistant Salmonella enterica serovar Heidelberg in Québec and Ontario, Canada.

PubMed

Otto, Simon J G; Carson, Carolee A; Finley, Rita L; Thomas, M Kate; Reid-Smith, Richard J; McEwen, Scott A

2014-11-01

A stochastic model was used to estimate the number of human cases of ceftiofur-resistant Salmonella enterica serovar Heidelberg in Québec and Ontario attributable to chicken consumption and excess cases attributable to human prior antimicrobial consumption. The annual mean incidence of S. Heidelberg (Québec/Ontario) decreased from 70/62 cases per 100 000 in 2004 to 29/30 cases per 100 000 in 2007 (Québec)/2008 (Ontario), increasing to 59/45 cases per 100 000 in 2011. The annual mean incidence of ceftiofur-resistant cases from chicken decreased from 8/7 cases per 100 000 in 2004 to 1/1 cases per 100 000 in 2007 (Québec)/2008 (Ontario), increasing to 7/5 cases per 100 000 in 2011. The annual mean total number of excess ceftiofur-resistant cases from chicken attributable to human prior antimicrobial consumption (Québec/Ontario) decreased from 71/123 in 2004 to 6/24 in 2007 (Québec)/2008 (Ontario), but increased to 62/91 in 2011. This model will support future work to determine the increased severity, mortality and healthcare costs for ceftiofur-resistant Salmonella Heidelberg infections. These results provide a basis for the evaluation of future public health interventions to address antimicrobial resistance. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

C2 Approaches: Looking for the Sweet Spot

DTIC Science & Technology

2013-06-01

more information) IMAGE (see Lizotte et al., 2008; Lizotte, Bernier, Mokhtari , & Boivin, 2013) was developed as a suite of generic representation...439–446). Fukuoka, Japan. Lizotte, M., Bernier, F., Mokhtari , M., & Boivin, E. (2013). IMAGE Final Report: An Interactive Computer-aided Cognition...Capability for C4ISR Complexity Discovery (No. TR 2013-397). Québec, Canada: Defence R&D Canada - Valcartier. Lizotte, M., Bernier, F., Mokhtari , M

Dynamical instability of a driven-dissipative electron-hole condensate in the BCS-BEC crossover region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hanai, Ryo; Littlewood, Peter B.; Ohashi, Yoji

2017-09-01

We present a stability analysis on a driven-dissipative electron-hole condensate in the BCS (Bardeen-Cooper-Schrieffer)-BEC (Bose-Einstein-condensation)-crossover region. Extending the combined BCS-Leggett theory with the generalized random phase approximation (GRPA) to the non-equilibrium case by employing the Keldysh formalism, we show that the pumping-and-decay of carriers causes a depairing effect on excitons. This phenomenon gives rise to an attractive interaction between excitons in the BEC regime, as well as a supercurrent that anomalously flows anti-parallel to ∇θ(r) (where θ(r) is the phase of the condensate) in the BCS regime, both leading to dynamical instabilities of an exciton-BEC.

Superconductivity in an electron band just above the Fermi level: possible route to BCS-BEC superconductivity.

PubMed

Okazaki, K; Ito, Y; Ota, Y; Kotani, Y; Shimojima, T; Kiss, T; Watanabe, S; Chen, C-T; Niitaka, S; Hanaguri, T; Takagi, H; Chainani, A; Shin, S

2014-02-28

Conventional superconductivity follows Bardeen-Cooper-Schrieffer(BCS) theory of electrons-pairing in momentum-space, while superfluidity is the Bose-Einstein condensation(BEC) of atoms paired in real-space. These properties of solid metals and ultra-cold gases, respectively, are connected by the BCS-BEC crossover. Here we investigate the band dispersions in FeTe(0.6)Se(0.4)(Tc = 14.5 K ~ 1.2 meV) in an accessible range below and above the Fermi level(EF) using ultra-high resolution laser angle-resolved photoemission spectroscopy. We uncover an electron band lying just 0.7 meV (~8 K) above EF at the Γ-point, which shows a sharp superconducting coherence peak with gap formation below Tc. The estimated superconducting gap Δ and Fermi energy [Symbol: see text]F indicate composite superconductivity in an iron-based superconductor, consisting of strong-coupling BEC in the electron band and weak-coupling BCS-like superconductivity in the hole band. The study identifies the possible route to BCS-BEC superconductivity.

Progress towards broadband Raman quantum memory in Bose-Einstein condensates

NASA Astrophysics Data System (ADS)

Saglamyurek, Erhan; Hrushevskyi, Taras; Smith, Benjamin; Leblanc, Lindsay

2017-04-01

Optical quantum memories are building blocks for quantum information technologies. Efficient and long-lived storage in combination with high-speed (broadband) operation are key features required for practical applications. While the realization has been a great challenge, Raman memory in Bose-Einstein condensates (BECs) is a promising approach, due to negligible decoherence from diffusion and collisions that leads to seconds-scale memory times, high efficiency due to large atomic density, the possibility for atom-chip integration with micro photonics, and the suitability of the far off-resonant Raman approach with storage of broadband photons (over GHz) [5]. Here we report our progress towards Raman memory in a BEC. We describe our apparatus recently built for producing BEC with 87Rb atoms, and present the observation of nearly pure BEC with 5x105 atoms at 40 nK. After showing our initial characterizations, we discuss the suitability of our system for Raman-based light storage in our BEC.

Spin-orbit coupling manipulating composite topological spin textures in atomic-molecular Bose-Einstein condensates

NASA Astrophysics Data System (ADS)

Liu, Chao-Fei; Juzeliūnas, Gediminas; Liu, W. M.

2017-02-01

Atomic-molecular Bose-Einstein condensates (BECs) offer brand new opportunities to revolutionize quantum gases and probe the variation of fundamental constants with unprecedented sensitivity. The recent realization of spin-orbit coupling (SOC) in BECs provides a new platform for exploring completely new phenomena unrealizable elsewhere. In this study, we find a way of creating a Rashba-Dresselhaus SOC in atomic-molecular BECs by combining the spin-dependent photoassociation and Raman coupling, which can control the formation and distribution of a different type of topological excitation—carbon-dioxide-like skyrmion. This skyrmion is formed by two half-skyrmions of molecular BECs coupling with one skyrmion of atomic BECs, where the two half-skyrmions locate at both sides of one skyrmion. Carbon-dioxide-like skyrmion can be detected by measuring the vortices structures using the time-of-flight absorption imaging technique in real experiments. Furthermore, we find that SOC can effectively change the occurrence of the Chern number in k space, which causes the creation of topological spin textures from some separated carbon-dioxide-like monomers each with topological charge -2 to a polymer chain of the skyrmions. This work helps in creating dual SOC atomic-molecular BECs and opens avenues to manipulate topological excitations.

Stationary solutions for the nonlinear Schrödinger equation modeling three-dimensional spherical Bose-Einstein condensates in general potentials.

PubMed

Mallory, Kristina; Van Gorder, Robert A

2015-07-01

Stationary solutions for the cubic nonlinear Schrödinger equation modeling Bose-Einstein condensates (BECs) confined in three spatial dimensions by general forms of a potential are studied through a perturbation method and also numerically. Note that we study both repulsive and attractive BECs under similar frameworks in order to deduce the effects of the potentials in each case. After outlining the general framework, solutions for a collection of specific confining potentials of physical relevance to experiments on BECs are provided in order to demonstrate the approach. We make several observations regarding the influence of the particular potentials on the behavior of the BECs in these cases, comparing and contrasting the qualitative behavior of the attractive and repulsive BECs for potentials of various strengths and forms. Finally, we consider the nonperturbative where the potential or the amplitude of the solutions is large, obtaining various qualitative results. When the kinetic energy term is small (relative to the nonlinearity and the confining potential), we recover the expected Thomas-Fermi approximation for the stationary solutions. Naturally, this also occurs in the large mass limit. Through all of these results, we are able to understand the qualitative behavior of spherical three-dimensional BECs in weak, intermediate, or strong confining potentials.

CYBERWAR-2012/13: Siegel 2011 Predicted Cyberwar Via ACHILLES-HEEL DIGITS BEQS BEC ZERO-DIGIT BEC of/in ACHILLES-HEEL DIGITS Log-Law Algebraic-Inversion to ONLY BEQS BEC Digit-Physics U Barabasi Network/Graph-Physics BEQS BEC JAMMING Denial-of-Access(DOA) Attacks 2012-Instantiations

NASA Astrophysics Data System (ADS)

Huffmann, Master; Siegel, Edward Carl-Ludwig

2013-03-01

Newcomb-Benford(NeWBe)-Siegel log-law BEC Digit-Physics Network/Graph-Physics Barabasi et.al. evolving-``complex''-networks/graphs BEC JAMMING DOA attacks: Amazon(weekends: Microsoft I.E.-7/8(vs. Firefox): Memorial-day, Labor-day,...), MANY U.S.-Banks:WF,BoA,UB,UBS,...instantiations AGAIN militate for MANDATORY CONVERSION to PARALLEL ANALOG FAULT-TOLERANT but slow(er) SECURITY-ASSURANCE networks/graphs in parallel with faster ``sexy'' DIGITAL-Networks/graphs:``Cloud'', telecomm: n-G,..., because of common ACHILLES-HEEL VULNERABILITY: DIGITS!!! ``In fast-hare versus slow-tortoise race, Slow-But-Steady ALWAYS WINS!!!'' (Zeno). {Euler [#s(1732)] ∑- ∏()-Riemann[Monats. Akad. Berlin (1859)] ∑- ∏()- Kummer-Bernoulli (#s)}-Newcomb [Am.J.Math.4(1),39 (81) discovery of the QUANTUM!!!]-{Planck (01)]}-{Einstein (05)]-Poincar e [Calcul Probabilités,313(12)]-Weyl[Goett. Nach.(14); Math.Ann.77,313(16)]-(Bose (24)-Einstein(25)]-VS. -Fermi (27)-Dirac(27))-Menger [Dimensiontheorie(29)]-Benford [J.Am. Phil.Soc.78,115(38)]-Kac[Maths Stats.-Reason. (55)]- Raimi [Sci.Am.221,109(69)]-Jech-Hill [Proc.AMS,123,3,887(95)] log-function

BEC, a Novel Enterotoxin of Clostridium perfringens Found in Human Clinical Isolates from Acute Gastroenteritis Outbreaks

PubMed Central

Yonogi, Shinya; Matsuda, Shigeaki; Kawai, Takao; Yoda, Tomoko; Harada, Tetsuya; Kumeda, Yuko; Gotoh, Kazuyoshi; Hiyoshi, Hirotaka; Nakamura, Shota; Kodama, Toshio

2014-01-01

Clostridium perfringens is a causative agent of food-borne gastroenteritis for which C. perfringens enterotoxin (CPE) has been considered an essential factor. Recently, we experienced two outbreaks of food-borne gastroenteritis in which non-CPE producers of C. perfringens were strongly suspected to be the cause. Here, we report a novel enterotoxin produced by C. perfringens isolates, BEC (binary enterotoxin of C. perfringens). Culture supernatants of the C. perfringens strains showed fluid-accumulating activity in rabbit ileal loop and suckling mouse assays. Purification of the enterotoxic substance in the supernatants and high-throughput sequencing of genomic DNA of the strains revealed BEC, composed of BECa and BECb. BECa and BECb displayed limited amino acid sequence similarity to other binary toxin family members, such as the C. perfringens iota toxin. The becAB genes were located on 54.5-kb pCP13-like plasmids. Recombinant BECb (rBECb) alone had fluid-accumulating activity in the suckling mouse assay. Although rBECa alone did not show enterotoxic activity, rBECa enhanced the enterotoxicity of rBECb when simultaneously administered in suckling mice. The entertoxicity of the mutant in which the becB gene was disrupted was dramatically decreased compared to that of the parental strain. rBECa showed an ADP-ribosylating activity on purified actin. Although we have not directly evaluated whether BECb delivers BECa into cells, rounding of Vero cells occurred only when cells were treated with both rBECa and rBECb. These results suggest that BEC is a novel enterotoxin of C. perfringens distinct from CPE, and that BEC-producing C. perfringens strains can be causative agents of acute gastroenteritis in humans. Additionally, the presence of becAB on nearly identical plasmids in distinct lineages of C. perfringens isolates suggests the involvement of horizontal gene transfer in the acquisition of the toxin genes. PMID:24664508

Theory of a Nearly Two-Dimensional Dipolar Bose Gas

DTIC Science & Technology

2016-05-11

temperatures, and when roton excitations are present. Further, BECs in nearly 2D geometries take the form of quasi -condensates, or BECs with finite spatial...extent. Quasi -condensates behave like BECs on shorter length scales, but not on longer length scales. The project incorporates the presence of a quasi ... Quasi -Condensate 23 J. Superfluidity 25 III. Results 26 A. Three Dimensions with Contact Interactions 26 B. Two Dimensions with Contact Interactions

Design of a Transparent-Transponder System.

DTIC Science & Technology

1980-11-01

the slight advantage of re- ducing the number of frequencies needed. There are, however, some good reasons why a minimum CW tone capability should be...C. Link Computations In this section we evaluate the capacity quotient of three links: (1) the uplink, (2) the downlink reference or pilot signal...sequences of several lengths, we have some protection against this problem. However, as the code is shortened the spread-spectrum process- ing gai !L against

Reduction in polyamine catabolism leads to spermine-mediated airway epithelial injury and induces asthma features.

PubMed

Jain, Vaibhav; Raina, Shikha; Gheware, Atish Prabhakar; Singh, Rita; Rehman, Rakhshinda; Negi, Vinny; Murray Stewart, Tracy; Mabalirajan, Ulaganathan; Mishra, Adarsh Kumar; Casero, Robert A; Agrawal, Anurag; Ghosh, Balaram

2018-05-05

Airway epithelial injury is a crucial component of acute and severe asthma pathogenesis and a promising target for treatment of refractory asthma. However, the underlying mechanism of epithelial injury remains poorly explored. Though high levels of polyamines, mainly spermine, have been found in asthma and co-morbidity, their role in airway epithelial injury and the cause of their altered levels in asthma has not been explored. We measured key polyamine metabolic enzymes in lung samples from normal and asthmatic subjects and in mice with OVA-induced allergic airway inflammation (AAI). Polyamine metabolism was modulated using pharmacologic/genetic modulators. Epithelial stress and apoptosis were measured by TSLP levels and TUNEL assay, respectively. We found loss of the polyamine catabolic enzymes spermidine/spermine-N (1)-acetyltransferase-1 (SAT1) and spermine oxidase (SMOX) predominantly in bronchial epithelial cells (BECs) of human asthmatic lung samples and mice with AAI. In naïve mice, SAT1 or SMOX knockdown led to airway hyper-responsiveness, remodeling and BEC apoptosis. Conversely, in mice with AAI, overexpression of either SAT1 or SMOX alleviated asthmatic features and reduced TSLP levels and BEC apoptosis. Similarly, while pharmacological induction of SAT1 and SMOX using the polyamine analogue bis(ethyl)norspermine (BENSPM) alleviated asthmatic features with reduced TSLP levels and BEC apoptosis, pharmacological inhibition of these enzymes using BERENIL or MDL72527, respectively, worsened them. Spermine accumulation in lungs correlated with BEC apoptosis, and spermine treatment caused apoptosis of human BEAS-2B cells in vitro. Spermine induces BEC injury. Induction of polyamine catabolism may represent a novel therapeutic approach for asthma via reversing BEC stress. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment.

PubMed

Pichavant, Muriel; Charbonnier, Anne-Sophie; Taront, Solenne; Brichet, Anne; Wallaert, Benoît; Pestel, Joel; Tonnel, André-Bernard; Gosset, Philippe

2005-04-01

Airway dendritic cells (DCs) are crucial for allergen-induced sensitization and inflammation in allergic asthma. After allergen challenge, an increased number of DCs is observed in airway epithelium from patients with allergy. Because Der p 1, a cysteine protease allergen from Dermatophagoides pteronyssinus , induces chemokine production by bronchial epithelial cells (BECs), the purpose of this investigation was to evaluate the capacity of BEC exposed to Der p 1 to recruit DCs. Chemotactic activity of BEAS-2B, a bronchial epithelial cell line, and BECs from nonatopic controls and patients with allergic asthma was evaluated on the migration of precursors, immature and mature monocyte-derived DCs (MDDCs), and CD34 + -derived Langerhans cells (LCs). C-C chemokine ligand (CCL)-2, CCL5, and C-X-C chemokine ligand 10 production by BEAS-2B and BEC was increased after Der p 1 exposure, whereas the proenzyme proDer p 1 devoid of enzymatic activity had no effect. Der p 1 stimulation of BEAS-2B and BEC from both groups increased significantly the recruitment of MDDC precursors, depending on CCL2, CCL5, and C-X-C chemokine ligand 10 production. In a reconstituted polarized epithelium, apical application of Der p 1 enhanced MDDC precursor migration into the epithelial layer. Moreover, Der p 1 stimulation of BEC from patients with asthma but not from controls increased the migration of LC precursors, mainly dependent on CCL20 secretion. No migration of immature and mature DCs was observed. These data confirmed that BECs participate in the homeostasis of the DC network present within the bronchial epithelium through the secretion of chemokines. In allergic asthma, upregulation of CCL20 production induced LC recruitment, the role of which remains to be determined.

Anti-inflammatory effects of antibacterials on human bronchial epithelial cells

PubMed Central

2009-01-01

Background Human Bronchial epithelial cells (hu-BEC) have been claimed to play a significant role in the pathogenesis of chronic inflammatory airway diseases like COPD. In this context IL-8 and GM-CSF have been shown to be key cytokines. Some antibiotics which are routinely used to treat lower respiratory tract infections have been shown to exert additional immunomodulatory or anti-inflammatory effects. We investigated whether these effects can also be detected in hu-BEC. Methods Hu-BEC obtained from patients undergoing lung resections were transferred to air-liquid-interface (ALI) culture. These cultures were incubated with cefuroxime (CXM, 10-62.5 mg/l), azithromycin (AZM, 0.1-1.5 mg/l), levofloxacin (LVX, 1-8 mg/l) and moxifloxacin (MXF, 1-16 mg/l). The spontaneous and TNF-α (10 ng/ml) induced expression and release of IL-8 and GM-CSF were measured using PCR and ELISA in the absence or presence of these antibiotics. Results The spontaneous IL-8 and GM-CSF release was significantly reduced with MXF (8 mg/l) by 37 ± 20% and 45 ± 31%, respectively (both p < 0.01). IL-8 release in TNF-α stimulated hu-BEC decreased by 16 ± 8% (p < 0.05) with AZM (1.5 mg/l). With MXF a concentration dependent decrease of IL-8 release was noted up to 39 ± 7% (p < 0.05). GM-CSF release from TNF-α stimulated hu-BEC was maximally decreased by 35 ± 24% (p < 0.01) with MXF (4 mg/l). Conclusion Using ALI cultures of hu-BEC we observed differential effects of antibiotics on spontaneous and TNF-α induced cytokine release. Our data suggest that MXF and AZM, beyond bactericidal effects, may attenuate the inflammatory process mediated by hu-BEC. PMID:19788749

An IMU-Aided Body-Shadowing Error Compensation Method for Indoor Bluetooth Positioning

PubMed Central

Deng, Zhongliang

2018-01-01

Research on indoor positioning technologies has recently become a hotspot because of the huge social and economic potential of indoor location-based services (ILBS). Wireless positioning signals have a considerable attenuation in received signal strength (RSS) when transmitting through human bodies, which would cause significant ranging and positioning errors in RSS-based systems. This paper mainly focuses on the body-shadowing impairment of RSS-based ranging and positioning, and derives a mathematical expression of the relation between the body-shadowing effect and the positioning error. In addition, an inertial measurement unit-aided (IMU-aided) body-shadowing detection strategy is designed, and an error compensation model is established to mitigate the effect of body-shadowing. A Bluetooth positioning algorithm with body-shadowing error compensation (BP-BEC) is then proposed to improve both the positioning accuracy and the robustness in indoor body-shadowing environments. Experiments are conducted in two indoor test beds, and the performance of both the BP-BEC algorithm and the algorithms without body-shadowing error compensation (named no-BEC) is evaluated. The results show that the BP-BEC outperforms the no-BEC by about 60.1% and 73.6% in terms of positioning accuracy and robustness, respectively. Moreover, the execution time of the BP-BEC algorithm is also evaluated, and results show that the convergence speed of the proposed algorithm has an insignificant effect on real-time localization. PMID:29361718

An IMU-Aided Body-Shadowing Error Compensation Method for Indoor Bluetooth Positioning.

PubMed

Deng, Zhongliang; Fu, Xiao; Wang, Hanhua

2018-01-20

Research on indoor positioning technologies has recently become a hotspot because of the huge social and economic potential of indoor location-based services (ILBS). Wireless positioning signals have a considerable attenuation in received signal strength (RSS) when transmitting through human bodies, which would cause significant ranging and positioning errors in RSS-based systems. This paper mainly focuses on the body-shadowing impairment of RSS-based ranging and positioning, and derives a mathematical expression of the relation between the body-shadowing effect and the positioning error. In addition, an inertial measurement unit-aided (IMU-aided) body-shadowing detection strategy is designed, and an error compensation model is established to mitigate the effect of body-shadowing. A Bluetooth positioning algorithm with body-shadowing error compensation (BP-BEC) is then proposed to improve both the positioning accuracy and the robustness in indoor body-shadowing environments. Experiments are conducted in two indoor test beds, and the performance of both the BP-BEC algorithm and the algorithms without body-shadowing error compensation (named no-BEC) is evaluated. The results show that the BP-BEC outperforms the no-BEC by about 60.1% and 73.6% in terms of positioning accuracy and robustness, respectively. Moreover, the execution time of the BP-BEC algorithm is also evaluated, and results show that the convergence speed of the proposed algorithm has an insignificant effect on real-time localization.

Crosstalk between apoptosis and autophagy within the Beclin 1 interactome.

PubMed

Maiuri, Maria Chiara; Criollo, Alfredo; Kroemer, Guido

2010-02-03

Although the essential genes for autophagy (Atg) have been identified, the molecular mechanisms through which Atg proteins control 'self eating' in mammalian cells remain elusive. Beclin 1 (Bec1), the mammalian orthologue of yeast Atg6, is part of the class III phosphatidylinositol 3-kinase (PI3K) complex that induces autophagy. The first among an increasing number of Bec1-interacting proteins that has been identified is the anti-apoptotic protein Bcl-2. The dissociation of Bec1 from Bcl-2 is essential for its autophagic activity, and Bcl-2 only inhibits autophagy when it is present in the endoplasmic reticulum (ER). A paper in this issue of the EMBO Journal has identified a novel protein, NAF-1 (nutrient-deprivation autophagy factor-1), that binds Bcl-2 at the ER. NAF-1 is a component of the inositol-1,4,5 trisphosphate (IP3) receptor complex, which contributes to the interaction of Bcl-2 with Bec1 and is required for Bcl-2 to functionally antagonize Bec1-mediated autophagy. This work provides mechanistic insights into how autophagy- and apoptosis-regulatory molecules crosstalk at the ER.

Bacillus Anthracis Spores of the bclA Mutant Exhibit Increased Adherence to Epithelial Cells, Fibroblasts, and Endothelial Cells but not to Macrophages

DTIC Science & Technology

2007-09-01

immunofluorescence (IFM) and light microscopy. Samples were fixed in forma- lin, stained with immunofluorescent dyes (as described below) or spore stain ( malachite ...BEC. Adherence was assessed by microscopic observation of the infected cells stained with malachite green and counterstaining of the BEC. For enzymatic...this significant difference, BEC infected with spores were stained with malachite green and counter- stained with Wright-Giemsa (Fig. 1B and C). This

Bose-Einstein condensation of dark matter axions.

PubMed

Sikivie, P; Yang, Q

2009-09-11

We show that cold dark matter axions thermalize and form a Bose-Einstein condensate (BEC). We obtain the axion state in a homogeneous and isotropic universe, and derive the equations governing small axion perturbations. Because they form a BEC, axions differ from ordinary cold dark matter in the nonlinear regime of structure formation and upon entering the horizon. Axion BEC provides a mechanism for the production of net overall rotation in dark matter halos, and for the alignment of cosmic microwave anisotropy multipoles.

48 CFR 227.7203-15 - Subcontractor rights in computer software or computer software documentation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... computer software or computer software documentation. 227.7203-15 Section 227.7203-15 Federal Acquisition... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-15 Subcontractor rights in computer software or computer software documentation. (a...

48 CFR 227.7203-15 - Subcontractor rights in computer software or computer software documentation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... computer software or computer software documentation. 227.7203-15 Section 227.7203-15 Federal Acquisition... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-15 Subcontractor rights in computer software or computer software documentation. (a...

48 CFR 227.7203-15 - Subcontractor rights in computer software or computer software documentation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... computer software or computer software documentation. 227.7203-15 Section 227.7203-15 Federal Acquisition... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-15 Subcontractor rights in computer software or computer software documentation. (a...

48 CFR 227.7203-15 - Subcontractor rights in computer software or computer software documentation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... computer software or computer software documentation. 227.7203-15 Section 227.7203-15 Federal Acquisition... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-15 Subcontractor rights in computer software or computer software documentation. (a...

48 CFR 227.7203-15 - Subcontractor rights in computer software or computer software documentation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... computer software or computer software documentation. 227.7203-15 Section 227.7203-15 Federal Acquisition... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-15 Subcontractor rights in computer software or computer software documentation. (a...

Entanglement between pairing and screening in the Gorkov-Melik-Barkhudarov correction to the critical temperature throughout the BCS-BEC crossover

NASA Astrophysics Data System (ADS)

Pisani, L.; Perali, A.; Pieri, P.; Strinati, G. Calvanese

2018-01-01

The problem of the theoretical description of the critical temperature Tc of a Fermi superfluid dates back to the work by Gorkov and Melik-Barkhudarov (GMB), who addressed it for a weakly coupled (dilute) superfluid in what would today be referred to as the (extreme) BCS (weak-coupling) limit of the BCS-BEC crossover. The point made in this context by GMB was that particle-particle (pairing) excitations, which are responsible for superfluidity to occur below Tc, and particle-hole excitations, which give rise to screening also in a normal system, get effectively disentangled from each other in the BCS limit, thus yielding a reduction by a factor of 2.2 of the value of Tc obtained when neglecting screening effects. Subsequent work on this topic, that was aimed at extending the original GMB argument away from the BCS limit with diagrammatic methods, has tout court kept this disentangling between pairing and screening throughout the BCS-BEC crossover, without realizing that the conditions for it to be valid are soon violated away from the BCS limit. Here, we reconsider this problem from a more general perspective and argue that pairing and screening are intrinsically entangled with each other along the whole BCS-BEC crossover but for the BCS limit considered by GMB, with the particle-hole excitations soon transmuting into particle-particle excitations away from this limit. We substantiate our argument by performing a detailed numerical calculation of the GMB diagrammatic contribution suitably extended to the whole BCS-BEC crossover, where the full wave-vector and frequency dependence occurring in the repeated in-medium two-particle scattering is duly taken into account. Our numerical calculations are tested against analytic results available in both the BCS and BEC limits, and the contribution of the GMB diagrammatic term to the scattering length of composite bosons in the BEC limit is highlighted. We calculate Tc throughout the BCS-BEC crossover and find that it agrees quite well with quantum Monte Carlo calculations and experimental data available in the unitarity regime.

48 CFR 227.7202 - Commercial computer software and commercial computer software documentation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... software and commercial computer software documentation. 227.7202 Section 227.7202 Federal Acquisition... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7202 Commercial computer software and commercial computer software documentation. ...

48 CFR 227.7203 - Noncommercial computer software and noncommercial computer software documentation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... software and noncommercial computer software documentation. 227.7203 Section 227.7203 Federal Acquisition... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203 Noncommercial computer software and noncommercial computer software documentation. ...

48 CFR 227.7203 - Noncommercial computer software and noncommercial computer software documentation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... software and noncommercial computer software documentation. 227.7203 Section 227.7203 Federal Acquisition... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203 Noncommercial computer software and noncommercial computer software documentation. ...

48 CFR 227.7203 - Noncommercial computer software and noncommercial computer software documentation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... software and noncommercial computer software documentation. 227.7203 Section 227.7203 Federal Acquisition... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203 Noncommercial computer software and noncommercial computer software documentation. ...

48 CFR 227.7202 - Commercial computer software and commercial computer software documentation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... software and commercial computer software documentation. 227.7202 Section 227.7202 Federal Acquisition... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7202 Commercial computer software and commercial computer software documentation. ...

48 CFR 227.7203 - Noncommercial computer software and noncommercial computer software documentation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... software and noncommercial computer software documentation. 227.7203 Section 227.7203 Federal Acquisition... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203 Noncommercial computer software and noncommercial computer software documentation. ...

48 CFR 227.7202 - Commercial computer software and commercial computer software documentation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... software and commercial computer software documentation. 227.7202 Section 227.7202 Federal Acquisition... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7202 Commercial computer software and commercial computer software documentation. ...

48 CFR 227.7202 - Commercial computer software and commercial computer software documentation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... software and commercial computer software documentation. 227.7202 Section 227.7202 Federal Acquisition... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7202 Commercial computer software and commercial computer software documentation. ...

48 CFR 227.7202 - Commercial computer software and commercial computer software documentation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... software and commercial computer software documentation. 227.7202 Section 227.7202 Federal Acquisition... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7202 Commercial computer software and commercial computer software documentation. ...

48 CFR 227.7203 - Noncommercial computer software and noncommercial computer software documentation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... software and noncommercial computer software documentation. 227.7203 Section 227.7203 Federal Acquisition... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203 Noncommercial computer software and noncommercial computer software documentation. ...

48 CFR 227.7202-3 - Rights in commercial computer software or commercial computer software documentation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... computer software or commercial computer software documentation. 227.7202-3 Section 227.7202-3 Federal... CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7202-3 Rights in commercial computer software or commercial computer software documentation...

48 CFR 227.7202-3 - Rights in commercial computer software or commercial computer software documentation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... computer software or commercial computer software documentation. 227.7202-3 Section 227.7202-3 Federal... CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7202-3 Rights in commercial computer software or commercial computer software documentation...

48 CFR 227.7203-2 - Acquisition of noncommercial computer software and computer software documentation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... noncommercial computer software and computer software documentation. 227.7203-2 Section 227.7203-2 Federal... CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-2 Acquisition of noncommercial computer software and computer software documentation. (a...

48 CFR 227.7203-2 - Acquisition of noncommercial computer software and computer software documentation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... noncommercial computer software and computer software documentation. 227.7203-2 Section 227.7203-2 Federal... CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-2 Acquisition of noncommercial computer software and computer software documentation. (a...

48 CFR 227.7203-2 - Acquisition of noncommercial computer software and computer software documentation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... noncommercial computer software and computer software documentation. 227.7203-2 Section 227.7203-2 Federal... CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-2 Acquisition of noncommercial computer software and computer software documentation. (a...

48 CFR 227.7203-10 - Contractor identification and marking of computer software or computer software documentation to...

Code of Federal Regulations, 2014 CFR

2014-10-01

... and marking of computer software or computer software documentation to be furnished with restrictive... Rights in Computer Software and Computer Software Documentation 227.7203-10 Contractor identification and marking of computer software or computer software documentation to be furnished with restrictive markings...

48 CFR 227.7203-2 - Acquisition of noncommercial computer software and computer software documentation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... noncommercial computer software and computer software documentation. 227.7203-2 Section 227.7203-2 Federal... CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-2 Acquisition of noncommercial computer software and computer software documentation. (a...

48 CFR 227.7202-3 - Rights in commercial computer software or commercial computer software documentation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... computer software or commercial computer software documentation. 227.7202-3 Section 227.7202-3 Federal... CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7202-3 Rights in commercial computer software or commercial computer software documentation...

48 CFR 227.7203-10 - Contractor identification and marking of computer software or computer software documentation to...

Code of Federal Regulations, 2011 CFR

2011-10-01

... and marking of computer software or computer software documentation to be furnished with restrictive... Rights in Computer Software and Computer Software Documentation 227.7203-10 Contractor identification and marking of computer software or computer software documentation to be furnished with restrictive markings...

48 CFR 227.7202-3 - Rights in commercial computer software or commercial computer software documentation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... computer software or commercial computer software documentation. 227.7202-3 Section 227.7202-3 Federal... CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7202-3 Rights in commercial computer software or commercial computer software documentation...

48 CFR 227.7203-10 - Contractor identification and marking of computer software or computer software documentation to...

Code of Federal Regulations, 2012 CFR

2012-10-01

... and marking of computer software or computer software documentation to be furnished with restrictive... Rights in Computer Software and Computer Software Documentation 227.7203-10 Contractor identification and marking of computer software or computer software documentation to be furnished with restrictive markings...

48 CFR 227.7202-3 - Rights in commercial computer software or commercial computer software documentation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... computer software or commercial computer software documentation. 227.7202-3 Section 227.7202-3 Federal... CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7202-3 Rights in commercial computer software or commercial computer software documentation...

48 CFR 227.7203-10 - Contractor identification and marking of computer software or computer software documentation to...

Code of Federal Regulations, 2010 CFR

2010-10-01

... and marking of computer software or computer software documentation to be furnished with restrictive... Rights in Computer Software and Computer Software Documentation 227.7203-10 Contractor identification and marking of computer software or computer software documentation to be furnished with restrictive markings...

48 CFR 227.7203-10 - Contractor identification and marking of computer software or computer software documentation to...

Code of Federal Regulations, 2013 CFR

2013-10-01

... and marking of computer software or computer software documentation to be furnished with restrictive... Rights in Computer Software and Computer Software Documentation 227.7203-10 Contractor identification and marking of computer software or computer software documentation to be furnished with restrictive markings...

48 CFR 227.7203-2 - Acquisition of noncommercial computer software and computer software documentation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... noncommercial computer software and computer software documentation. 227.7203-2 Section 227.7203-2 Federal... CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-2 Acquisition of noncommercial computer software and computer software documentation. (a...

48 CFR 227.7203-16 - Providing computer software or computer software documentation to foreign governments, foreign...

Code of Federal Regulations, 2011 CFR

2011-10-01

... software or computer software documentation to foreign governments, foreign contractors, or international... Rights in Computer Software and Computer Software Documentation 227.7203-16 Providing computer software or computer software documentation to foreign governments, foreign contractors, or international...

48 CFR 227.7203-16 - Providing computer software or computer software documentation to foreign governments, foreign...

Code of Federal Regulations, 2013 CFR

2013-10-01

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48 CFR 227.7203-16 - Providing computer software or computer software documentation to foreign governments, foreign...

Code of Federal Regulations, 2012 CFR

2012-10-01

... software or computer software documentation to foreign governments, foreign contractors, or international... Rights in Computer Software and Computer Software Documentation 227.7203-16 Providing computer software or computer software documentation to foreign governments, foreign contractors, or international...

48 CFR 227.7203-16 - Providing computer software or computer software documentation to foreign governments, foreign...

Code of Federal Regulations, 2014 CFR

2014-10-01

... software or computer software documentation to foreign governments, foreign contractors, or international... Rights in Computer Software and Computer Software Documentation 227.7203-16 Providing computer software or computer software documentation to foreign governments, foreign contractors, or international...

48 CFR 227.7203-16 - Providing computer software or computer software documentation to foreign governments, foreign...

Code of Federal Regulations, 2010 CFR

2010-10-01

... software or computer software documentation to foreign governments, foreign contractors, or international... Rights in Computer Software and Computer Software Documentation 227.7203-16 Providing computer software or computer software documentation to foreign governments, foreign contractors, or international...

48 CFR 227.7203-3 - Early identification of computer software or computer software documentation to be furnished to...

Code of Federal Regulations, 2010 CFR

2010-10-01

... computer software or computer software documentation to be furnished to the Government with restrictions on..., DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-3 Early identification of computer software or computer software documentation to be furnished to the Government with...

48 CFR 227.7203-3 - Early identification of computer software or computer software documentation to be furnished to...

Code of Federal Regulations, 2012 CFR

2012-10-01

... computer software or computer software documentation to be furnished to the Government with restrictions on..., DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-3 Early identification of computer software or computer software documentation to be furnished to the Government with...

48 CFR 227.7203-3 - Early identification of computer software or computer software documentation to be furnished to...

Code of Federal Regulations, 2011 CFR

2011-10-01

... computer software or computer software documentation to be furnished to the Government with restrictions on..., DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-3 Early identification of computer software or computer software documentation to be furnished to the Government with...

48 CFR 227.7203-3 - Early identification of computer software or computer software documentation to be furnished to...

Code of Federal Regulations, 2013 CFR

2013-10-01

... computer software or computer software documentation to be furnished to the Government with restrictions on..., DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-3 Early identification of computer software or computer software documentation to be furnished to the Government with...

48 CFR 227.7203-3 - Early identification of computer software or computer software documentation to be furnished to...

Code of Federal Regulations, 2014 CFR

2014-10-01

... computer software or computer software documentation to be furnished to the Government with restrictions on..., DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-3 Early identification of computer software or computer software documentation to be furnished to the Government with...

Bose-Einstein Condensate-Hidden Riches for New Forms of Technology and Energy Generation; Potential for Glimpse into Inner Reality

NASA Astrophysics Data System (ADS)

Reed, Don

With the announcement of the recent successful production of a Bose-Einstein condensate (BEC) of photons, a circle has been completed which started in 1925 with the vision of Albert Einstein and Satyendra Nath Bose - a sustained macroscopic condensed state of matter where all atoms are in the same lowest quantum state. The creation of an all-optical BEC, involving a surprisingly straightforward "tabletop" method which bypasses the normally requisite laser/evaporative cooling equipment and ultra-high vacuum chambers necessary for production of the standard delicate atomic BEC, elevates this phenomenon to a new level well beyond its current perception as mere laboratory curiosity. Accordingly, this development certainly heralds eventual incorporation of atomic and photon BECs as standard operating components of energy-efficient mechanical, optical and electrical systems, implying novel ingenious engineering protocols amenable to all the tools of non-linear and quantum optics. Pointing towards such a promising technological future are the suggestion that a photon BEC could serve as a new high-energy ultra-violet (UV) laser photon source, as well as the recent unprecedented implementation of a closed-loop atom circuit (toroidal atomic BEC) demonstrating precise control of superfluid current flow, forecasting the coveted development of an atomic SQUID. Perhaps more significantly, the new highly robust and manageable optical BEC will allow heretofore unfathomable precise probing of the atomic and nano-levels of nature, affording novel high-quality testing procedures of the major foundations of quantum mechanics itself. Such a primary advancement, providing a clearer glimpse into the microscopic realms, may present us as never before with an unprecedented view of the quantum engine that underpins physical reality itself and help place the contextual nature of entanglement and quantum superposition on a firmer foundation. Thus, further progress in achieving mastery over the precise flexible manipulation of BEC states could demonstrate that quantum contextuality might be an unsuspected over-arching archetypal principle in nature, leading to new insight in regards to the interpretation of quantum mechanics as applied to all levels of nature. Moreover, it will be shown that this concealed and hence heretofore unsuspected contextual aspect of natural laws, as exemplified by the dynamics underlying BEC structure, could be brought to bear to account for physical anomalies inexplicable using current paradigms, such as the claimed energy yields from low-energy nuclear reactions (as represented by the so-called process of "cold fusion"), making this phenomenon more tractable and rendered less controversial.

48 CFR 227.7203-14 - Conformity, acceptance, and warranty of computer software and computer software documentation.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., and warranty of computer software and computer software documentation. 227.7203-14 Section 227.7203-14... GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-14 Conformity, acceptance, and warranty of computer software and computer...

48 CFR 227.7203-14 - Conformity, acceptance, and warranty of computer software and computer software documentation.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., and warranty of computer software and computer software documentation. 227.7203-14 Section 227.7203-14... GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-14 Conformity, acceptance, and warranty of computer software and computer...

48 CFR 227.7203-14 - Conformity, acceptance, and warranty of computer software and computer software documentation.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., and warranty of computer software and computer software documentation. 227.7203-14 Section 227.7203-14... GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-14 Conformity, acceptance, and warranty of computer software and computer...

48 CFR 227.7203-14 - Conformity, acceptance, and warranty of computer software and computer software documentation.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., and warranty of computer software and computer software documentation. 227.7203-14 Section 227.7203-14... GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-14 Conformity, acceptance, and warranty of computer software and computer...

48 CFR 227.7203-14 - Conformity, acceptance, and warranty of computer software and computer software documentation.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., and warranty of computer software and computer software documentation. 227.7203-14 Section 227.7203-14... GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-14 Conformity, acceptance, and warranty of computer software and computer...

Modulated amplitude waves in collisionally inhomogeneous Bose Einstein condensates

NASA Astrophysics Data System (ADS)

Porter, Mason A.; Kevrekidis, P. G.; Malomed, Boris A.; Frantzeskakis, D. J.

2007-05-01

We investigate the dynamics of an effectively one-dimensional Bose-Einstein condensate (BEC) with scattering length a subjected to a spatially periodic modulation, a=a(x)=a(x+L). This “collisionally inhomogeneous” BEC is described by a Gross-Pitaevskii (GP) equation whose nonlinearity coefficient is a periodic function of x. We transform this equation into a GP equation with a constant coefficient and an additional effective potential and study a class of extended wave solutions of the transformed equation. For weak underlying inhomogeneity, the effective potential takes a form resembling a superlattice, and the amplitude dynamics of the solutions of the constant-coefficient GP equation obey a nonlinear generalization of the Ince equation. In the small-amplitude limit, we use averaging to construct analytical solutions for modulated amplitude waves (MAWs), whose stability we subsequently examine using both numerical simulations of the original GP equation and fixed-point computations with the MAWs as numerically exact solutions. We show that “on-site” solutions, whose maxima correspond to maxima of a(x), are more robust and likely to be observed than their “off-site” counterparts.

Subsonic and Supersonic Effects in Bose-Einstein Condensate

NASA Technical Reports Server (NTRS)

Zak, Michail

2003-01-01

A paper presents a theoretical investigation of subsonic and supersonic effects in a Bose-Einstein condensate (BEC). The BEC is represented by a time-dependent, nonlinear Schroedinger equation that includes terms for an external confining potential term and a weak interatomic repulsive potential proportional to the number density of atoms. From this model are derived Madelung equations, which relate the quantum phase with the number density, and which are used to represent excitations propagating through the BEC. These equations are shown to be analogous to the classical equations of flow of an inviscid, compressible fluid characterized by a speed of sound (g/Po)1/2, where g is the coefficient of the repulsive potential and Po is the unperturbed mass density of the BEC. The equations are used to study the effects of a region of perturbation moving through the BEC. The excitations created by a perturbation moving at subsonic speed are found to be described by a Laplace equation and to propagate at infinite speed. For a supersonically moving perturbation, the excitations are found to be described by a wave equation and to propagate at finite speed inside a Mach cone.

Ultrathin Graphene-Protein Supercapacitors for Miniaturized Bioelectronics.

PubMed

Mosa, Islam M; Pattammattel, Ajith; Kadimisetty, Karteek; Pande, Paritosh; El-Kady, Maher F; Bishop, Gregory W; Novak, Marc; Kaner, Richard B; Basu, Ashis K; Kumar, Challa V; Rusling, James F

2017-09-06

Nearly all implantable bioelectronics are powered by bulky batteries which limit device miniaturization and lifespan. Moreover, batteries contain toxic materials and electrolytes that can be dangerous if leakage occurs. Herein, an approach to fabricate implantable protein-based bioelectrochemical capacitors (bECs) employing new nanocomposite heterostructures in which 2D reduced graphene oxide sheets are interlayered with chemically modified mammalian proteins, while utilizing biological fluids as electrolytes is described. This protein-modified reduced graphene oxide nanocomposite material shows no toxicity to mouse embryo fibroblasts and COS-7 cell cultures at a high concentration of 1600 μg mL -1 which is 160 times higher than those used in bECs, unlike the unmodified graphene oxide which caused toxic cell damage even at low doses of 10 μg mL -1 . The bEC devices are 1 μm thick, fully flexible, and have high energy density comparable to that of lithium thin film batteries. COS-7 cell culture is not affected by long-term exposure to encapsulated bECs over 4 d of continuous charge/discharge cycles. These bECs are unique, protein-based devices, use serum as electrolyte, and have the potential to power a new generation of long-life, miniaturized implantable devices.

Experiments with BECs in a Painted Potential: Atom SQUID, Matter Wave Bessel Beams, and Matter Wave Circuits

NASA Astrophysics Data System (ADS)

Boshier, Malcolm; Ryu, Changhyun; Blackburn, Paul; Blinova, Alina; Henderson, Kevin

2014-05-01

The painted potential is a time-averaged optical dipole potential which is able to create arbitrary and dynamic two dimensional potentials for Bose Einstein condensates (BECs). This poster reports three recent experiments using this technique. First, we have realized the dc atom SQUID geometry of a BEC in a toroidal trap with two Josephson junctions. We observe Josephson effects, measure the critical current of the junctions, and find dynamic behavior that is in good agreement with the simple Josephson equations for a tunnel junction with the ideal sinusoidal current-phase relation expected for the parameters of the experiment. Second, we have used free expansion of a rotating toroidal BEC to create matter wave Bessel beams, which are of interest because perfect Bessel beams (plane waves with amplitude profiles described by Bessel functions) propagate without diffraction. Third, we have realized the basic circuit elements necessary to create complex matter wave circuits. We launch BECs at arbitrary velocity along straight waveguides, propagate them around curved waveguides and stadium-shaped waveguide traps, and split them coherently at y-junctions that can also act as switches. Supported by LANL/LDRD.

Composite cryogels for lysozyme purification.

PubMed

Baydemir, Gözde; Türkoğlu, Emir Alper; Andaç, Müge; Perçin, Işık; Denizli, Adil

2015-01-01

Beads-embedded novel composite cryogel was synthesized to purify lysozyme (Lyz) from chicken egg white. The poly(hydroxyethyl methacrylate-N-methacryloyl-L-phenylalanine) (PHEMAPA) beads of smaller than 5 µm size were synthesized by suspension polymerization and then embedded into a poly(hydroxyethyl methacrylate) (PHEMA)-based cryogel column. The PHEMAPA bead-embedded cryogel (BEC) column was characterized by swelling tests, scanning electron microscopy (SEM), surface area measurements by the Brunauer-Emmett-Teller (BET) method, elemental analysis, and flow dynamics. The specific surface area of the PHEMAPA BEC was found as 41.2 m(2) /g using BET measurements. Lyz-binding experiments were performed using aqueous solutions in different conditions such as initial Lyz concentration, pH, flow rate, temperature, and NaCl concentration of an aqueous medium. The PHEMAPA BEC column could be used after 10 adsorption-desorption studies without any significant loss in adsorption capacity of Lyz. The PHEMAPA BEC column was used to purify Lyz from chicken egg white, and gel electrophoresis was used to estimate the purity of Lyz. The chromatographic application of the PHEMAPA BEC column was also performed using fast protein liquid chromatography. © 2014 International Union of Biochemistry and Molecular Biology, Inc.

The BCS-BEC Crossover

NASA Astrophysics Data System (ADS)

Parish, Meera M.

2015-09-01

This chapter presents the crossover from the Bardeen-Cooper-Schrieffer (BCS) state of weakly correlated pairs of fermions to the Bose-Einstein condensation (BEC) of diatomic molecules in the atomic Fermi gas. Our aim is to provide a pedagogical review of the BCS-BEC crossover, with an emphasis on the basic concepts, particularly those that are not generally known or are difficult to find in the literature. We shall not attempt to give an exhaustive survey of current research in the limited space here; where possible, we will direct the reader to more extensive reviews.

The Weak-Coupling of Bose-Einstein Condensates

NASA Astrophysics Data System (ADS)

Zhou, Xiao-Ji; Ma, Zao-Yuan; Chen, Xu-Zong; Wang, Yi-Qiu

2003-04-01

The coherent characteristics of four trapped Bose-Einstein condensates (BEC) conjunct one by one in a ring shape which is divided by two far off-resonant lasers, are studied. Four coupled Gross-Pitaevskii equations are used to describe the dynamics of the system. Two kinds of self-trapping effects are discussed in the coupled BECs, and the phase diagrams for different initial conditions and different coupling strengths are discussed. This study can be used to determine interaction parameters between atoms in BEC. The project supported by National Natural Science Foundation of China under Grant No. 60271003

48 CFR 227.7203-8 - Deferred delivery and deferred ordering of computer software and computer software documentation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... deferred ordering of computer software and computer software documentation. 227.7203-8 Section 227.7203-8... GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-8 Deferred delivery and deferred ordering of computer software and computer...

48 CFR 227.7203-8 - Deferred delivery and deferred ordering of computer software and computer software documentation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... deferred ordering of computer software and computer software documentation. 227.7203-8 Section 227.7203-8... GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-8 Deferred delivery and deferred ordering of computer software and computer...

48 CFR 227.7203-8 - Deferred delivery and deferred ordering of computer software and computer software documentation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... deferred ordering of computer software and computer software documentation. 227.7203-8 Section 227.7203-8... GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-8 Deferred delivery and deferred ordering of computer software and computer...

48 CFR 227.7203-8 - Deferred delivery and deferred ordering of computer software and computer software documentation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... deferred ordering of computer software and computer software documentation. 227.7203-8 Section 227.7203-8... GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-8 Deferred delivery and deferred ordering of computer software and computer...

48 CFR 227.7203-8 - Deferred delivery and deferred ordering of computer software and computer software documentation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... deferred ordering of computer software and computer software documentation. 227.7203-8 Section 227.7203-8... GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-8 Deferred delivery and deferred ordering of computer software and computer...

A new apparatus for studies of quantized vortex dynamics in dilute-gas Bose-Einstein condensates

NASA Astrophysics Data System (ADS)

Newman, Zachary L.

The presence of quantized vortices and a high level of control over trap geometries and other system parameters make dilute-gas Bose-Einstein condensates (BECs) a natural environment for studies of vortex dynamics and quantum turbulence in superfluids, primary interests of the BEC group at the University of Arizona. Such research may lead to deeper understanding of the nature of quantum fluid dynamics and far-from-equilbrium phenomena. Despite the importance of quantized vortex dynamics in the fields of superfluidity, superconductivity and quantum turbulence, direct imaging of vortices in trapped BECs remains a significant technical challenge. This is primarily due to the small size of the vortex core in a trapped gas, which is typically a few hundred nanometers in diameter. In this dissertation I present the design and construction of a new 87Rb BEC apparatus with the goal of studying vortex dynamics in trapped BECs. The heart of the apparatus is a compact vacuum chamber with a custom, all-glass science cell designed to accommodate the use of commercial high-numerical-aperture microscope objectives for in situ imaging of vortices. The designs for the new system are, in part, based on prior work in our group on in situ imaging of vortices. Here I review aspects of our prior work and discuss some of the successes and limitations that are relevant to the new apparatus. The bulk of the thesis is used to described the major subsystems of the new apparatus which include the vacuum chamber, the laser systems, the magnetic transfer system and the final magnetic trap for the atoms. Finally, I demonstrate the creation of a BEC of ˜ 2 x 106 87Rb atoms in our new system and show that the BEC can be transferred into a weak, spherical, magnetic trap with a well defined magnetic field axis that may be useful for future vortex imaging studies.

48 CFR 252.227-7014 - Rights in noncommercial computer software and noncommercial computer software documentation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... computer software and noncommercial computer software documentation. 252.227-7014 Section 252.227-7014... Rights in noncommercial computer software and noncommercial computer software documentation. As prescribed in 227.7203-6(a)(1), use the following clause. Rights in Noncommercial Computer Software and...

48 CFR 252.227-7014 - Rights in noncommercial computer software and noncommercial computer software documentation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... computer software and noncommercial computer software documentation. 252.227-7014 Section 252.227-7014... Rights in noncommercial computer software and noncommercial computer software documentation. As prescribed in 227.7203-6(a)(1), use the following clause. Rights in Noncommercial Computer Software and...

48 CFR 252.227-7014 - Rights in noncommercial computer software and noncommercial computer software documentation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... computer software and noncommercial computer software documentation. 252.227-7014 Section 252.227-7014... Rights in noncommercial computer software and noncommercial computer software documentation. As prescribed in 227.7203-6(a)(1), use the following clause. Rights in Noncommercial Computer Software and...

48 CFR 252.227-7014 - Rights in noncommercial computer software and noncommercial computer software documentation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... computer software and noncommercial computer software documentation. 252.227-7014 Section 252.227-7014... Rights in noncommercial computer software and noncommercial computer software documentation. As prescribed in 227.7203-6(a)(1), use the following clause. Rights in Noncommercial Computer Software and...

48 CFR 252.227-7014 - Rights in noncommercial computer software and noncommercial computer software documentation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... computer software and noncommercial computer software documentation. 252.227-7014 Section 252.227-7014... Rights in noncommercial computer software and noncommercial computer software documentation. As prescribed in 227.7203-6(a)(1), use the following clause. Rights in Noncommercial Computer Software and...

Tuning across the BCS-BEC crossover in superconducting Fe1+ySexTe1-x : An angle-resolved photoemission study

NASA Astrophysics Data System (ADS)

Rinott, Shahar; Ribak, Amit; Chashka, Khanan; Randeria, Mohit; Kanigel, Amit

The crossover from Bardeen-Cooper-Schrieffer (BCS) superconductivity to Bose-Einstein condensation (BEC) was never realized in quantum materials. It is difficult to realize because, unlike in ultra cold atoms, one cannot tune the pairing interaction. We realize the BCS-BEC crossover in a nearly compensated semimetal Fe1+ySexTe1-x by tuning the Fermi energy ɛF via chemical doping, which permits us to systematically change Δ /ɛF from 0 . 16 to 0 . 50 , where Δ is the superconducting (SC) gap. We use angle-resolved photoemission spectroscopy to measure the Fermi energy, the SC gap and characteristic changes in the SC state electronic dispersion as the system evolves from a BCS to a BEC regime. Our results raise important questions about the crossover in multi-band superconductors which go beyond those addressed in the context of cold atoms.

NON-Shor Factorization Via BEQS BEC: Watkins Number-Theory ``Pure''-Mathematics U With Statistical-Physics; Benford Log-Law Inversion to ONLY BEQS digit d=0 BEC!!!

NASA Astrophysics Data System (ADS)

Lyons, M.; Siegel, Edward Carl-Ludwig

2011-03-01

Weiss-Page-Holthaus[Physica A,341,586(04); http://arxiv.org/abs/cond-mat/0403295] number-FACTORIZATION VIA BEQS BEC VS.(?) Shor-algorithm, strongly-supporting Watkins' [www.secamlocal.ex.ac.uk/people/staff/mrwatkin/] Intersection of number-theory "pure"-maths WITH (Statistical)-Physics, as Siegel[AMS Joint.Mtg.(02)-Abs.973-60-124] Benford logarithmic-law algebraic-INVERSION to ONLY BEQS with d=0 digit P (d = 0) > = oogapFULBEC ! ! ! SiegelRiemann - hypothesisproofviaRayleigh [ Phil . Trans . CLXI (1870) ] - Polya [ Math . Ann . (21) ] - [ Random - WalksElectric - Nets . , MAA (81) ] - nderson [ PRL (58) ] - localization - Siegel [ Symp . Fractals , MRSFallMtg . (89) - 5 - papers ! ! ! ] FUZZYICS = CATEGORYICS : [ LOCALITY ]- MORPHISM / CROSSOVER / AUTMATHCAT / DIM - CAT / ANTONYM- > (GLOBALITY) FUNCTOR / SYNONYM / concomitancetonoise = / Fluct . - Dissip . theorem / FUNCTOR / SYNONYM / equivalence / proportionalityto = > generalized - susceptibilitypower - spectrum [ FLAT / FUNCTIONLESS / WHITE ]- MORPHISM / CROSSOVER / AUTMATHCAT / DIM - CAT / ANTONYM- > HYPERBOLICITY/ZIPF-law INEVITABILITY) intersection with ONLY BEQS BEC).

Semi-classical dynamics of superradiant Rayleigh scattering in a Bose-Einstein condensate

NASA Astrophysics Data System (ADS)

Müller, J. H.; Witthaut, D.; le Targat, R.; Arlt, J. J.; Polzik, E. S.; Hilliard, A. J.

2016-10-01

Due to its coherence properties and high optical depth, a Bose-Einstein condensate [BEC] provides an ideal setting to investigate collective atom-light interactions. Superradiant light scattering [SLS] in a BEC is a fascinating example of such an interaction. It is an analogous process to Dicke superradiance, in which an electronically inverted sample decays collectively, leading to the emission of one or more light pulses in a well-defined direction. Through time-resolved measurements of the superradiant light pulses emitted by an end-pumped BEC, we study the close connection of SLS with Dicke superradiance. A 1D model of the system yields good agreement with the experimental data and shows that the dynamics result from the structures that build up in the light and matter-wave fields along the BEC. This paves the way for exploiting the atom-photon correlations generated by the superradiance.

Vortex Lattices in the Bose-Fermi Superfluid Mixture.

PubMed

Jiang, Yuzhu; Qi, Ran; Shi, Zhe-Yu; Zhai, Hui

2017-02-24

In this Letter we show that the vortex lattice structure in the Bose-Fermi superfluid mixture can undergo a sequence of structure transitions when the Fermi superfluid is tuned from the BCS regime to the BEC regime. This is due to the difference in the vortex core structure of a Fermi superfluid in the BCS regime and in the BEC regime. In the BCS regime the vortex core is nearly filled, while the density at the vortex core gradually decreases until it empties out in the BEC regime. Therefore, with the density-density interaction between the Bose and the Fermi superfluids, interaction between the two sets of vortex lattices gets stronger in the BEC regime, which yields the structure transition of vortex lattices. In view of the recent realization of this superfluid mixture and vortices therein, our theoretical predication can be verified experimentally in the near future.

Gravitational waves as a new probe of Bose-Einstein condensate Dark Matter

NASA Astrophysics Data System (ADS)

Dev, P. S. Bhupal; Lindner, Manfred; Ohmer, Sebastian

2017-10-01

There exists a class of ultralight Dark Matter (DM) models which could give rise to a Bose-Einstein condensate (BEC) in the early universe and behave as a single coherent wave instead of individual particles in galaxies. We show that a generic BEC-DM halo intervening along the line of sight of a gravitational wave (GW) signal could induce an observable change in the speed of GWs, with the effective refractive index depending only on the mass and self-interaction of the constituent DM particles and the GW frequency. Hence, we propose to use the deviation in the speed of GWs as a new probe of the BEC-DM parameter space. With a multi-messenger approach to GW astronomy and/or with extended sensitivity to lower GW frequencies, the entire BEC-DM parameter space can be effectively probed by our new method in the near future.

A cross-cultural comparison of population gambling patterns and regulatory frameworks: France and Québec.

PubMed

Kairouz, Sylvia; Paradis, Catherine; Nadeau, Louise; Tovar, Marie-Line; Pousset, Maud

2016-12-01

Few empirical studies have examined the relationships between differing regulatory approaches and patterns of gambling behaviors. This article reports on a correlational cross-cultural comparison of differences in the regulatory approaches and gambling behavior among general adult populations in France and Québec, Canada. We drew data from two large population surveys conducted in France and Québec (N=27 653 and N=11 888, respectively). We found diverging and converging aspects of government regulatory policies. Statistical analyses demonstrated significantly higher participation rates and prevalence of 'assiduous gamblers' in Québec. In France, among assiduous gamblers, the proportion of moderate-risk and probable pathological gamblers is significantly higher. Future research should examine environmental conditions and varying gambling offerings, as well as gambling regulation, to determine their potential influence on gambling behaviors.

Kosterlitz-Thouless transition and vortex-antivortex lattice melting in two-dimensional Fermi gases with p - or d -wave pairing

NASA Astrophysics Data System (ADS)

Cao, Gaoqing; He, Lianyi; Huang, Xu-Guang

2017-12-01

We present a theoretical study of the finite-temperature Kosterlitz-Thouless (KT) and vortex-antivortex lattice (VAL) melting transitions in two-dimensional Fermi gases with p - or d -wave pairing. For both pairings, when the interaction is tuned from weak to strong attractions, we observe a quantum phase transition from the Bardeen-Cooper-Schrieffer (BCS) superfluidity to the Bose-Einstein condensation (BEC) of difermions. The KT and VAL transition temperatures increase during this BCS-BEC transition and approach constant values in the deep BEC region. The BCS-BEC transition is characterized by the nonanalyticities of the chemical potential, the superfluid order parameter, and the sound velocities as functions of the interaction strength at both zero and finite temperatures; however, the temperature effect tends to weaken the nonanalyticities compared to the zero-temperature case. The effect of mismatched Fermi surfaces on the d -wave pairing is also studied.

Specific heat and effects of strong pairing fluctuations in a superfluid Fermi atom gas in the BCS-BEC crossover region

NASA Astrophysics Data System (ADS)

van Wyk, Pieter; Inotani, Daisuke; Ohashi, Yoji

2018-03-01

We theoretically investigate the specific heat at constant volume C V in the BCS(Bardeen-Cooper-Schrieffer)-BEC(Bose-Einstein-condensation)-crossover regime of an ultracold Fermi gas, below the superfluid phase transition temperature T c. Within the strong-coupling framework developed by Nozières and Schmitt-Rink, we show that the temperature dependence of C V drastically changes as one passes through the crossover region, and is sensitive to strong fluctuations in the Cooper channel near the unitarity limit. We also compare our results to a recent experiment on a 6Li unitary Fermi gas. Since fluctuation effects are a crucial key in the BCS-BEC-crossover phenomenon, our results would be helpful in considering how the fermionic BCS superfluid changes into BEC with increasing the interaction strength, from the viewpoint of specific heat.

Pairing fluctuations and the superfluid density through the BCS-BEC crossover

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taylor, E.; Griffin, A.; Fukushima, N.

2006-12-15

We derive an expression for the superfluid density of a uniform two-component Fermi gas through the BCS-BEC crossover in terms of the thermodynamic potential in the presence of an imposed superfluid flow. Treating the pairing fluctuations in a Gaussian approximation following the approach of Nozieres and Schmitt-Rink, we use this definition of {rho}{sub s} to obtain an explicit result which is valid at finite temperatures and over the full BCS-BEC crossover. It is crucial that the BCS gap {delta}, the chemical potential {mu}, and {rho}{sub s} all include the effect of fluctuations at the same level in a self-consistent manner.more » We show that the normal fluid density {rho}{sub n}{identical_to}n-{rho}{sub s} naturally separates into a sum of contributions from Fermi BCS quasiparticles ({rho}{sub n}{sup F}) and Bose collective modes ({rho}{sub n}{sup B}). The expression for {rho}{sub n}{sup F} is just Landau's formula for a BCS Fermi superfluid but now calculated over the BCS-BEC crossover. The expression for the Bose contribution {rho}{sub n}{sup B} is more complicated and only reduces to Landau's formula for a Bose superfluid in the extreme BEC limit, where all the fermions have formed stable Bose pairs and the Bogoliubov excitations of the associated molecular Bose condensate are undamped. In a companion paper, we present numerical calculations of {rho}{sub s} using an expression equivalent to the one derived in this paper, over the BCS-BEC crossover, including unitarity, and at finite temperatures.« less

Onsager Vortex Formation in Two-component Bose-Einstein Condensates

NASA Astrophysics Data System (ADS)

Han, Junsik; Tsubota, Makoto

2018-06-01

We numerically study the dynamics of quantized vortices in two-dimensional two-component Bose-Einstein condensates (BECs) trapped by a box potential. For one-component BECs in a box potential, it is known that quantized vortices form Onsager vortices, which are clusters of same-sign vortices. We confirm that the vortices of the two components spatially separate from each other — even for miscible two-component BECs — suppressing the formation of Onsager vortices. This phenomenon is caused by the repulsive interaction between vortices belonging to different components, hence, suggesting a new possibility for vortex phase separation.

Core structure of two-dimensional Fermi gas vortices in the BEC-BCS crossover region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Madeira, Lucas; Gandolfi, Stefano; Schmidt, Kevin E.

2017-05-02

We report T = 0 diffusion Monte Carlo results for the ground-state and vortex excitation of unpolarized spin-1/2 fermions in a two-dimensional disk. We investigate how vortex core structure properties behave over the BEC-BCS crossover. We calculate the vortex excitation energy, density pro les, and vortex core properties related to the current. We nd a density suppression at the vortex core on the BCS side of the crossover and a depleted core on the BEC limit. Size-effect dependencies in the disk geometry were carefully studied.

Quantum Hall effect with small numbers of vortices in Bose-Einstein condensates

NASA Astrophysics Data System (ADS)

Byrnes, Tim; Dowling, Jonathan P.

2015-08-01

When vortices are displaced in Bose-Einstein condensates (BECs), the Magnus force gives the system a momentum transverse in the direction to the displacement. We show that BECs in long channels with vortices exhibit a quantization of the current response with respect to the spatial vortex distribution. The quantization originates from the well-known topological property of the phase around a vortex; it is an integer multiple of 2 π . In a way similar to that of the integer quantum Hall effect, the current along the channel is related to this topological phase and can be extracted from two experimentally measurable quantities: the total momentum of the BEC and the spatial distribution. The quantization is in units of m /2 h , where m is the mass of the atoms and h is Planck's constant. We derive an exact vortex momentum-displacement relation for BECs in long channels under general circumstances. Our results present the possibility that the configuration described here can be used as a novel way of measuring the mass of the atoms in the BEC using a topological invariant of the system. If an accurate determination of the plateaus are experimentally possible, this gives the possibility of a topological quantum mass standard and precise determination of the fine structure constant.

Impurity bubbles in a BEC

NASA Astrophysics Data System (ADS)

Timmermans, Eddy; Blinova, Alina; Boshier, Malcolm

2013-05-01

Polarons (particles that interact with the self-consistent deformation of the host medium that contains them) self-localize when strongly coupled. Dilute Bose-Einstein condensates (BECs) doped with neutral distinguishable atoms (impurities) and armed with a Feshbach-tuned impurity-boson interaction provide a unique laboratory to study self-localized polarons. In nature, self-localized polarons come in two flavors that exhibit qualitatively different behavior: In lattice systems, the deformation is slight and the particle is accompanied by a cloud of collective excitations as in the case of the Landau-Pekar polarons of electrons in a dielectric lattice. In natural fluids and gases, the strongly coupled particle radically alters the medium, e.g. by expelling the host medium as in the case of the electron bubbles in superfluid helium. We show that BEC-impurities can self-localize in a bubble, as well as in a Landau-Pekar polaron state. The BEC-impurity system is fully characterized by only two dimensionless coupling constants. In the corresponding phase diagram the bubble and Landau-Pekar polaron limits correspond to large islands separated by a cross-over region. The same BEC-impurity species can be adiabatically Feshbach steered from the Landau-Pekar to the bubble regime. This work was funded by the Los Alamos LDRD program.

Disorder effects in the evolution from BCS to BEC superfluidity

NASA Astrophysics Data System (ADS)

Han, Li; de Melo, Carlos A. R. Sa

2009-03-01

We discuss the effects of disorder on the critical temperature of superfluids during the evolution from BCS to BEC. For s-wave superfluids we find that the critical temperature is weakly affected by disorder in the BCS regime as described in Anderson’s theorem, even less affected by disorder at zero chemical potential (near unitarity), but strongly affected by disorder in the BEC regime, where Anderson's theorem does not apply. This suggests that the superfluid is more robust to the effects of disorder at the interaction parameter where the chemical potential vanishes (close to unitarity). We construct a three dimensional phase diagram of critical temperature, disorder and interaction parameter [1], and show that there are regions of localized superfluidity, as well as insulating regions due to Anderson localization of fermions (BCS regime) and molecular bosons (BEC regime). The phase diagram for higher angular momentum (e.g. p-wave and d-wave) is also analyzed, where the effects of disorder are much more dramatic in the BCS regime in comparison to the s-wave case because pair breaking is strong, while the disorder effects in BEC regime are similar to what occurs in the s-wave case. [1] Li Han, C. A. R. Sa de Melo, arXiv:0812.xxxx

The BCS-BEC crossover: From ultra-cold Fermi gases to nuclear systems

NASA Astrophysics Data System (ADS)

Strinati, Giancarlo Calvanese; Pieri, Pierbiagio; Röpke, Gerd; Schuck, Peter; Urban, Michael

2018-04-01

This report addresses topics and questions of common interest in the fields of ultra-cold gases and nuclear physics in the context of the BCS-BEC crossover. By this crossover, the phenomena of Bardeen-Cooper-Schrieffer (BCS) superfluidity and Bose-Einstein condensation (BEC), which share the same kind of spontaneous symmetry breaking, are smoothly connected through the progressive reduction of the size of the fermion pairs involved as the fundamental entities in both phenomena. This size ranges, from large values when Cooper pairs are strongly overlapping in the BCS limit of a weak inter-particle attraction, to small values when composite bosons are non-overlapping in the BEC limit of a strong inter-particle attraction, across the intermediate unitarity limit where the size of the pairs is comparable with the average inter-particle distance. The BCS-BEC crossover has recently been realized experimentally, and essentially in all of its aspects, with ultra-cold Fermi gases. This realization, in turn, has raised the interest of the nuclear physics community in the crossover problem, since it represents an unprecedented tool to test fundamental and unanswered questions of nuclear many-body theory. Here, we focus on the several aspects of the BCS-BEC crossover, which are of broad joint interest to both ultra-cold Fermi gases and nuclear matter, and which will likely help to solve in the future some open problems in nuclear physics (concerning, for instance, neutron stars). Similarities and differences occurring in ultra-cold Fermi gases and nuclear matter will then be emphasized, not only about the relative phenomenologies but also about the theoretical approaches to be used in the two contexts. Common to both contexts is the fact that at zero temperature the BCS-BEC crossover can be described at the mean-field level with reasonable accuracy. At finite temperature, on the other hand, inclusion of pairing fluctuations beyond mean field represents an essential ingredient of the theory, especially in the normal phase where they account for precursor pairing effects. After an introduction to present the key concepts of the BCS-BEC crossover, this report discusses the mean-field treatment of the superfluid phase, both for homogeneous and inhomogeneous systems, as well as for symmetric (spin- or isospin-balanced) and asymmetric (spin- or isospin-imbalanced) matter. Pairing fluctuations in the normal phase are then considered, with their manifestations in thermodynamic and dynamic quantities. The last two Sections provide a more specialized discussion of the BCS-BEC crossover in ultra-cold Fermi gases and nuclear matter, respectively. The separate discussion in the two contexts aims at cross communicating to both communities topics and aspects which, albeit arising in one of the two fields, share a strong common interest.

Analytical theory of mesoscopic Bose-Einstein condensation in an ideal gas

NASA Astrophysics Data System (ADS)

Kocharovsky, Vitaly V.; Kocharovsky, Vladimir V.

2010-03-01

We find the universal structure and scaling of the Bose-Einstein condensation (BEC) statistics and thermodynamics (Gibbs free energy, average energy, heat capacity) for a mesoscopic canonical-ensemble ideal gas in a trap with an arbitrary number of atoms, any volume, and any temperature, including the whole critical region. We identify a universal constraint-cutoff mechanism that makes BEC fluctuations strongly non-Gaussian and is responsible for all unusual critical phenomena of the BEC phase transition in the ideal gas. The main result is an analytical solution to the problem of critical phenomena. It is derived by, first, calculating analytically the universal probability distribution of the noncondensate occupation, or a Landau function, and then using it for the analytical calculation of the universal functions for the particular physical quantities via the exact formulas which express the constraint-cutoff mechanism. We find asymptotics of that analytical solution as well as its simple analytical approximations which describe the universal structure of the critical region in terms of the parabolic cylinder or confluent hypergeometric functions. The obtained results for the order parameter, all higher-order moments of BEC fluctuations, and thermodynamic quantities perfectly match the known asymptotics outside the critical region for both low and high temperature limits. We suggest two- and three-level trap models of BEC and find their exact solutions in terms of the cutoff negative binomial distribution (which tends to the cutoff gamma distribution in the continuous limit) and the confluent hypergeometric distribution, respectively. Also, we present an exactly solvable cutoff Gaussian model of BEC in a degenerate interacting gas. All these exact solutions confirm the universality and constraint-cutoff origin of the strongly non-Gaussian BEC statistics. We introduce a regular refinement scheme for the condensate statistics approximations on the basis of the infrared universality of higher-order cumulants and the method of superposition and show how to model BEC statistics in the actual traps. In particular, we find that the three-level trap model with matching the first four or five cumulants is enough to yield remarkably accurate results for all interesting quantities in the whole critical region. We derive an exact multinomial expansion for the noncondensate occupation probability distribution and find its high-temperature asymptotics (Poisson distribution) and corrections to it. Finally, we demonstrate that the critical exponents and a few known terms of the Taylor expansion of the universal functions, which were calculated previously from fitting the finite-size simulations within the phenomenological renormalization-group theory, can be easily obtained from the presented full analytical solutions for the mesoscopic BEC as certain approximations in the close vicinity of the critical point.

Portrait of socio-economic inequality in childhood morbidity and mortality over time, Québec, 1990-2005.

PubMed

Barry, Mamadou S; Auger, Nathalie; Burrows, Stephanie

2012-06-01

To determine the age and cause groups contributing to absolute and relative socio-economic inequalities in paediatric mortality, hospitalisation and tumour incidence over time. Deaths (n= 9559), hospitalisations (n= 834,932) and incident tumours (n= 4555) were obtained for five age groupings (<1, 1-4, 5-9, 10-14, 15-19 years) and four periods (1990-1993, 1994-1997, 1998-2001, 2002-2005) for Québec, Canada. Age- and cause-specific morbidity and mortality rates for males and females were calculated across socio-economic status decile based on a composite deprivation score for 89 urban communities. Absolute and relative measures of inequality were computed for each age and cause. Mortality and morbidity rates tended to decrease over time, as did absolute and relative socio-economic inequalities for most (but not all) causes and age groups, although precision was low. Socio-economic inequalities persisted in the last period and were greater on the absolute scale for mortality and hospitalisation in early childhood, and on the relative scale for mortality in adolescents. Four causes (respiratory, digestive, infectious, genito-urinary diseases) contributed to the majority of absolute inequality in hospitalisation (males 85%, females 98%). Inequalities were not pronounced for cause-specific mortality and not apparent for tumour incidence. Socio-economic inequalities in Québec tended to narrow for most but not all outcomes. Absolute socio-economic inequalities persisted for children <10 years, and several causes were responsible for the majority of inequality in hospitalisation. Public health policies and prevention programs aiming to reduce socio-economic inequalities in paediatric health should account for trends that differ across age and cause of disease. © 2011 The Authors. Journal of Paediatrics and Child Health © 2011 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

48 CFR 227.7202-4 - Contract clause.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Software and Computer Software Documentation 227.7202-4 Contract clause. A specific contract clause governing the Government's rights in commercial computer software or commercial computer software..., release, perform, display, or disclose computer software or computer software documentation shall be...

48 CFR 227.7202-4 - Contract clause.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Software and Computer Software Documentation 227.7202-4 Contract clause. A specific contract clause governing the Government's rights in commercial computer software or commercial computer software..., release, perform, display, or disclose computer software or computer software documentation shall be...

48 CFR 227.7202-4 - Contract clause.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Software and Computer Software Documentation 227.7202-4 Contract clause. A specific contract clause governing the Government's rights in commercial computer software or commercial computer software..., release, perform, display, or disclose computer software or computer software documentation shall be...

48 CFR 227.7202-4 - Contract clause.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Software and Computer Software Documentation 227.7202-4 Contract clause. A specific contract clause governing the Government's rights in commercial computer software or commercial computer software..., release, perform, display, or disclose computer software or computer software documentation shall be...

48 CFR 227.7202-4 - Contract clause.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Software and Computer Software Documentation 227.7202-4 Contract clause. A specific contract clause governing the Government's rights in commercial computer software or commercial computer software..., release, perform, display, or disclose computer software or computer software documentation shall be...

Southern Québec in Late Winter

NASA Image and Video Library

2002-02-27

These images of Canada Québec province were acquired by NASA Terra satelliteon March 4, 2001.The region forests are a mixture of coniferous and hardwood trees, and ugar-shack festivities are held at this time of year to celebrate the beginning o

Testing the Bose-Einstein Condensate dark matter model at galactic cluster scale

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harko, Tiberiu; Liang, Pengxiang; Liang, Shi-Dong

The possibility that dark matter may be in the form of a Bose-Einstein Condensate (BEC) has been extensively explored at galactic scale. In particular, good fits for the galactic rotations curves have been obtained, and upper limits for the dark matter particle mass and scattering length have been estimated. In the present paper we extend the investigation of the properties of the BEC dark matter to the galactic cluster scale, involving dark matter dominated astrophysical systems formed of thousands of galaxies each. By considering that one of the major components of a galactic cluster, the intra-cluster hot gas, is describedmore » by King's β-model, and that both intra-cluster gas and dark matter are in hydrostatic equilibrium, bound by the same total mass profile, we derive the mass and density profiles of the BEC dark matter. In our analysis we consider several theoretical models, corresponding to isothermal hot gas and zero temperature BEC dark matter, non-isothermal gas and zero temperature dark matter, and isothermal gas and finite temperature BEC, respectively. The properties of the finite temperature BEC dark matter cluster are investigated in detail numerically. We compare our theoretical results with the observational data of 106 galactic clusters. Using a least-squares fitting, as well as the observational results for the dark matter self-interaction cross section, we obtain some upper bounds for the mass and scattering length of the dark matter particle. Our results suggest that the mass of the dark matter particle is of the order of μ eV, while the scattering length has values in the range of 10{sup −7} fm.« less

Perlecan Domain V Induces VEGf Secretion in Brain Endothelial Cells through Integrin α5β1 and ERK-Dependent Signaling Pathways

PubMed Central

Clarke, Douglas N.; Al Ahmad, Abraham; Lee, Boyeon; Parham, Christi; Auckland, Lisa; Fertala, Andrezj; Kahle, Michael; Shaw, Courtney S.; Roberts, Jill; Bix, Gregory J.

2012-01-01

Perlecan Domain V (DV) promotes brain angiogenesis by inducing VEGF release from brain endothelial cells (BECs) following stroke. In this study, we define the specific mechanism of DV interaction with the α5β1 integrin, identify the downstream signal transduction pathway, and further investigate the functional significance of resultant VEGF release. Interestingly, we found that the LG3 portion of DV, which has been suggested to possess most of DV’s angio-modulatory activity outside of the brain, binds poorly to α5β1 and induces less BEC proliferation compared to full length DV. Additionally, we implicate DV’s DGR sequence as an important element for the interaction of DV with α5β1. Furthermore, we investigated the importance of AKT and ERK signaling in DV-induced VEGF expression and secretion. We show that DV increases the phosphorylation of ERK, which leads to subsequent activation and stabilization of eIF4E and HIF-1α. Inhibition of ERK activity by U0126 suppressed DV-induced expression and secretion of VEGR in BECs. While DV was capable of phosphorylating AKT we show that AKT phosphorylation does not play a role in DV’s induction of VEGF expression or secretion using two separate inhibitors, LY294002 and Akt IV. Lastly, we demonstrate that VEGF activity is critical for DV increases in BEC proliferation, as well as angiogenesis in a BEC-neuronal co-culture system. Collectively, our findings expand our understanding of DV’s mechanism of action on BECs, and further support its potential as a novel stroke therapy. PMID:23028886

Speciation of arsenic in exfoliated urinary bladder epithelial cells from individuals exposed to arsenic in drinking water.

PubMed

Hernández-Zavala, Araceli; Valenzuela, Olga L; Matousek, Tomás; Drobná, Zuzana; Dĕdina, Jirí; García-Vargas, Gonzalo G; Thomas, David J; Del Razo, Luz M; Stýblo, Miroslav

2008-12-01

The concentration of arsenic in urine has been used as a marker of exposure to inorganic As (iAs). Relative proportions of urinary metabolites of iAs have been identified as potential biomarkers of susceptibility to iAs toxicity. However, the adverse effects of iAs exposure are ultimately determined by the concentrations of iAs metabolites in target tissues. In this study we examined the feasibility of analyzing As species in cells that originate in the urinary bladder, a target organ for As-induced cancer in humans. Exfoliated bladder epithelial cells (BECs) were collected from urine of 21 residents of Zimapan, Mexico, who were exposed to iAs in drinking water. We determined concentrations of iAs, methyl-As (MAs), and dimethyl-As (DMAs) in urine using conventional hydride generation-cryotrapping-atomic absorption spectrometry (HG-CT-AAS). We used an optimized HG-CT-AAS technique with detection limits of 12-17 pg As for analysis of As species in BECs. All urine samples and 20 of 21 BEC samples contained detectable concentrations of iAs, MAs, and DMAs. Sums of concentrations of these As species in BECs ranged from 0.18 to 11.4 ng As/mg protein and in urine from 4.8 to 1,947 ng As/mL. We found no correlations between the concentrations or ratios of As species in BECs and in urine. These results suggest that urinary levels of iAs metabolites do not necessarily reflect levels of these metabolites in the bladder epithelium. Thus, analysis of As species in BECs may provide a more effective tool for risk assessment of bladder cancer and other urothelial diseases associated with exposures to iAs.

48 CFR 12.212 - Computer software.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Computer software. 12.212... software. (a) Commercial computer software or commercial computer software documentation shall be acquired... required to— (1) Furnish technical information related to commercial computer software or commercial...

48 CFR 12.212 - Computer software.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Computer software. 12.212... software. (a) Commercial computer software or commercial computer software documentation shall be acquired... required to— (1) Furnish technical information related to commercial computer software or commercial...

48 CFR 12.212 - Computer software.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Computer software. 12.212... software. (a) Commercial computer software or commercial computer software documentation shall be acquired... required to— (1) Furnish technical information related to commercial computer software or commercial...

48 CFR 12.212 - Computer software.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Computer software. 12.212... software. (a) Commercial computer software or commercial computer software documentation shall be acquired... required to— (1) Furnish technical information related to commercial computer software or commercial...

48 CFR 12.212 - Computer software.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Computer software. 12.212... software. (a) Commercial computer software or commercial computer software documentation shall be acquired... required to— (1) Furnish technical information related to commercial computer software or commercial...

77 FR 58787 - Airworthiness Directives; Bombardier, Inc. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-24

..., Qu[eacute]bec H4S 1Y9, Canada; telephone 514-855-5000; fax 514-855-7401; email [email protected], Inc., 400 C[ocirc]te-Vertu Road West, Dorval, Qu[eacute]bec H4S 1Y9, Canada; telephone 514-855-5000...

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Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-19

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77 FR 45288 - Airworthiness Directives; Bombardier, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-31

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Quantum decoherence of phonons in Bose-Einstein condensates

NASA Astrophysics Data System (ADS)

Howl, Richard; Sabín, Carlos; Hackermüller, Lucia; Fuentes, Ivette

2018-01-01

We apply modern techniques from quantum optics and quantum information science to Bose-Einstein condensates (BECs) in order to study, for the first time, the quantum decoherence of phonons of isolated BECs. In the last few years, major advances in the manipulation and control of phonons have highlighted their potential as carriers of quantum information in quantum technologies, particularly in quantum processing and quantum communication. Although most of these studies have focused on trapped ion and crystalline systems, another promising system that has remained relatively unexplored is BECs. The potential benefits in using this system have been emphasized recently with proposals of relativistic quantum devices that exploit quantum states of phonons in BECs to achieve, in principle, superior performance over standard non-relativistic devices. Quantum decoherence is often the limiting factor in the practical realization of quantum technologies, but here we show that quantum decoherence of phonons is not expected to heavily constrain the performance of these proposed relativistic quantum devices.

A Non-Cell-Autonomous Role of BEC-1/BECN1/Beclin1 in Coordinating Cell-Cycle Progression and Stem Cell Proliferation during Germline Development.

PubMed

Ames, Kristina; Da Cunha, Dayse S; Gonzalez, Brenda; Konta, Marina; Lin, Feng; Shechter, Gabriel; Starikov, Lev; Wong, Sara; Bülow, Hannes E; Meléndez, Alicia

2017-03-20

The decision of stem cells to proliferate and differentiate is finely controlled. The Caenorhabditis elegans germline provides a tractable system for studying the mechanisms that control stem cell proliferation and homeostasis [1-4]. Autophagy is a conserved cellular recycling process crucial for cellular homeostasis in many different contexts [5], but its function in germline stem cell proliferation remains poorly understood. Here, we describe a function for autophagy in germline stem cell proliferation. We found that autophagy genes such as bec-1/BECN1/Beclin1, atg-16.2/ATG16L, atg-18/WIPI1/2, and atg-7/ATG7 are required for the late larval expansion of germline stem cell progenitors in the C. elegans gonad. We further show that BEC-1/BECN1/Beclin1 acts independently of the GLP-1/Notch or DAF-7/TGF-β pathways but together with the DAF-2/insulin IGF-1 receptor (IIR) signaling pathway to promote germline stem cell proliferation. Similar to DAF-2/IIR, BEC-1/BECN1/Beclin1, ATG-18/WIPI1/2, and ATG-16.2/ATG16L all promote cell-cycle progression and are negatively regulated by the phosphatase and tensin homolog DAF-18/PTEN. However, whereas BEC-1/BECN1/Beclin1 acts through the transcriptional regulator SKN-1/Nrf1, ATG-18/WIPI1/2 and ATG-16.2/ATG16L exert their function through the DAF-16/FOXO transcription factor. In contrast, ATG-7 functions in concert with the DAF-7/TGF-β pathway to promote germline proliferation and is not required for cell-cycle progression. Finally, we report that BEC-1/BECN1/Beclin1 functions non-cell-autonomously to facilitate cell-cycle progression and stem cell proliferation. Our findings demonstrate a novel non-autonomous role for BEC-1/BECN1/Beclin1 in the control of stem cell proliferation and cell-cycle progression, which may have implications for the understanding and development of therapies against malignant cell growth in the future. Copyright © 2017 Elsevier Ltd. All rights reserved.

Development and validation of parenting measures for body image and eating patterns in childhood.

PubMed

Damiano, Stephanie R; Hart, Laura M; Paxton, Susan J

2015-01-01

Evidence-based parenting interventions are important in assisting parents to help their children develop healthy body image and eating patterns. To adequately assess the impact of parenting interventions, valid parent measures are required. The aim of this study was to develop and assess the validity and reliability of two new parent measures, the Parenting Intentions for Body image and Eating patterns in Childhood (Parenting Intentions BEC) and the Knowledge Test for Body image and Eating patterns in Childhood (Knowledge Test BEC). Participants were 27 professionals working in research or clinical treatment of body dissatisfaction or eating disorders, and 75 parents of children aged 2-6 years, who completed the measures via an online questionnaire. Seven scenarios were developed for the Parenting Intentions BEC to describe common experiences about the body and food that parents might need to respond to in front of their child. Parents ranked four behavioural intentions, derived from the current literature on parenting risk factors for body dissatisfaction and unhealthy eating patterns in children. Two subscales were created, one representing positive behavioural intentions, the other negative behavioural intentions. After piloting a larger pool of items, 13 statements were used to construct the Knowledge Test BEC. These were designed to be factual statements about the influence of parent language, media, family meals, healthy eating, and self-esteem on child eating and body image. The validity of both measures was tested by comparing parent and professional scores, and reliability was assessed by comparing parent scores over two testing occasions. Compared with parents, professionals reported significantly higher scores on the Positive Intentions subscale and significantly lower on the Negative Intentions subscale of the Parenting Intentions BEC; confirming the discriminant validity of six out of the seven scenarios. Test-retest reliability was also confirmed as parent scores on the two Parenting Intentions subscales did not differ over time. Eleven out of the 13 Knowledge Test items demonstrated sufficient discriminant validity and test-retest reliability. Overall, results indicated that the six-scenario Parenting Intentions BEC and the 11-item Knowledge Test BEC are valid and reliable measures for parents of young children.

Dispersion Engineering of Bose-Einstein Condensates

NASA Astrophysics Data System (ADS)

Khamehchi, Mohammad Amin

The subject of this dissertation is engineering the dispersion relation for dilute Bose-Einstein condensates (BECs). When a BEC is immersed into suitably tailored laser fields its dispersion can be strongly modified. Prominent examples for such laser fields include optical lattice geometries and Raman dressing fields. The ability to engineer the dispersion of a BEC allows for the investigation of a range of phenomena related to quantum hydrodynamics and condensed matter. In the first context, this dissertation studies the excitation spectrum of a spin-orbit coupled (SOC) BEC. The spin-orbit coupling is generated by " dressing" the atoms with two Raman laser fields. The excitation spectrum has a Roton-like feature that can be altered by tuning the Raman laser parameters. It is demonstrated that the Roton mode can be softened, but it does not reach the ground state energy for the experimental conditions we had. Furthermore, the expansion of SOC BECs in 1D is studied by relaxing the trap allowing the BEC to expand in the SOC direction. Contrary to the findings for optical lattices, it is observed that the condensate partially occupies quasimomentum states with negative effective mass, and therefore an abrupt deceleration is observed although the mean field force is along the direction of expansion. In condensed-matter systems, a periodic lattice structure often plays an important role. In this context, an alternative to the Raman dressing scheme can be realized by coupling the s- and p- bands of a static optical lattice via a weak moving lattice. The bands can be treated as pseudo-spin states. It is shown that similar to the dispersion relation of a Raman dressed SOC, the quasimomentum of the ground state is different from zero. Coherent coupling of the SOC dispersion minima can lead to the realization of the stripe phase even though it is not the thermodynamic ground state of the system. Along the lines of studying the hydrodynamics of BECs, three novel multicomponent solitonic states are realized. It is shown that the solitons are structurally stable and the oscillation of vector dark-anti-dark solitons is studied in a weak harmonic trap.

Cytogenetic biomonitoring of primary school children exposed to air pollutants: micronuclei analysis of buccal epithelial cells.

PubMed

Demircigil, Gonca Çakmak; Erdem, Onur; Gaga, Eftade O; Altuğ, Hicran; Demirel, Gülçin; Özden, Özlem; Arı, Akif; Örnektekin, Sermin; Döğeroğlu, Tuncay; van Doorn, Wim; Burgaz, Sema

2014-01-01

There is an increasing attempt in the world to determine the exposures of children to environmental chemicals. To analyze the genotoxic effect of air pollution, micronucleus (MN) assay was carried out in buccal epithelial cells (BECs) of children living in an urban city of Turkey. Children from two schools at urban-traffic and suburban sites were investigated in summer and winter seasons for the determination of BEC-MN frequency (per mille) and frequency of BEC with MN (per mille). The same children were also recruited for lung function measurements within a MATRA project ("Together Towards Clean Air in Eskisehir and Iskenderun") Measured NO2 and SO2 concentrations did not exceed the European Union (EU) limit levels either in urban-traffic or suburban regions. Higher O3 concentrations were measured in the suburban site especially in the summer period. Particulate matter (PM2.5 and PM10) levels which did not differ statistically between two regions were above the EU limits in general. Although BEC-MN frequencies of children living in the suburban sites were higher in general, the difference between two regions was not significant either in the summer or winter periods. BEC-MN frequencies of the urban-traffic children were found to be significantly higher in summer period (mean ± SD, 2.68 ± 1.99) when compared to winter period (1.64 ± 1.59; p = 0.004). On the other hand, no seasonality was observed for the suburban children. Similar results have been obtained in the BEC frequency with MN in our study. In summer, BEC-MN frequencies were significantly increased with the decrease in pulmonary function levels based on forced expiratory flow between 25 and 75% of vital capacity (FEF25-75%) levels (p < 0.05). As a conclusion, children living in urban-traffic and suburban areas in the city of Eskişehir exhibited similar genotoxicity. Seasonal variation in genotoxicity may be interpreted as relatively high ozone levels and increasing time spent at outdoors in the summer.

Pilot study of quantitative analysis of background enhancement on breast MR images: association with menstrual cycle and mammographic breast density.

PubMed

Scaranelo, Anabel M; Carrillo, Maria Claudia; Fleming, Rachel; Jacks, Lindsay M; Kulkarni, Supriya R; Crystal, Pavel

2013-06-01

To perform semiautomated quantitative analysis of the background enhancement (BE) in a cohort of patients with newly diagnosed breast cancer and to correlate it with mammographic breast density and menstrual cycle. Informed consent was waived after the research ethics board approved this study. Results of 177 consecutive preoperative breast magnetic resonance (MR) examinations performed from February to December 2009 were reviewed; 147 female patients (median age, 48 years; range, 26-86 years) were included. Ordinal values of BE and breast density were described by two independent readers by using the Breast Imaging Reporting and Data System lexicon. The BE coefficient (BEC) was calculated thus: (SI2 · 100/SI1) - 100, where SI is signal intensity, SI2 is the SI enhancement measured in the largest anteroposterior dimension in the axial plane 1 minute after the contrast agent injection, and SI1is the SI before contrast agent injection. BEC was used for the quantitative analysis of BE. Menstrual cycle status was based on the last menstrual period. The Wilcoxon rank-sum or Kruskal-Wallis test was used to compare quantitative assessment groups. Cohen weighted κ was used to evaluate agreement. Of 147 patients, 68 (46%) were premenopausal and 79 (54%) were postmenopausal. The quantitative BEC was associated with the menstrual status (BEC in premenopausal women, 31.48 ± 20.68 [standard deviation]; BEC in postmenopausal women, 25.65 ± 16.74; P = .02). The percentage of overall BE was higher when the MR imaging was performed in women in the inadequate phase of the cycle (<35 days, not 7-14 days; mean BEC, 35.7) compared with women in the postmenopausal group (P = .001). Premenopausal women had significantly higher BEC when compared with postmenopausal women (P = .03). There was no significant difference in the percentage of BE between breast density groups. Premenopausal women with breast cancer, and specifically women in the inadequate phase of the cycle, presented with higher quantitative BE than postmenopausal women. No association was found between BE and breast density.

Cloning and Expression of a Ralstonia eutropha HF39 Gene Mediating Indigo Formation in Escherichia coli

PubMed Central

Drewlo, Sascha; Brämer, Christian O.; Madkour, Mohamed; Mayer, Frank; Steinbüchel, Alexander

2001-01-01

On complex medium Escherichia coli strains carrying hybrid plasmid pBEC/EE:11.0, pSKBEC/BE:9.0, pSKBEC/PP:3.3, or pSKBEC/PP:2.4 harboring genomic DNA of Ralstonia eutropha HF39 produced a blue pigment characterized as indigo by several chemical and spectroscopic methods. A 1,251-bp open reading frame (bec) was cloned and sequenced. The deduced amino acid sequence of bec showed only weak similarities to short-chain acyl-coenzyme A dehydrogenases, and the gene product catalyzed formation of indoxyl, a reactive preliminary stage for production of indigo. PMID:11282658

Wildlife software: procedures for publication of computer software

USGS Publications Warehouse

Samuel, M.D.

1990-01-01

Computers and computer software have become an integral part of the practice of wildlife science. Computers now play an important role in teaching, research, and management applications. Because of the specialized nature of wildlife problems, specific computer software is usually required to address a given problem (e.g., home range analysis). This type of software is not usually available from commercial vendors and therefore must be developed by those wildlife professionals with particular skill in computer programming. Current journal publication practices generally prevent a detailed description of computer software associated with new techniques. In addition, peer review of journal articles does not usually include a review of associated computer software. Thus, many wildlife professionals are usually unaware of computer software that would meet their needs or of major improvements in software they commonly use. Indeed most users of wildlife software learn of new programs or important changes only by word of mouth.

48 CFR 227.7203-17 - Overseas contracts with foreign sources.

Code of Federal Regulations, 2013 CFR

2013-10-01

... COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-17 Overseas contracts with foreign sources. (a) The clause at 252.227-7032, Rights in Technical Data and Computer Software... Noncommercial Computer Software and Noncommercial Computer Software Documentation, when the Government requires...

48 CFR 227.7203-17 - Overseas contracts with foreign sources.

Code of Federal Regulations, 2010 CFR

2010-10-01

... COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-17 Overseas contracts with foreign sources. (a) The clause at 252.227-7032, Rights in Technical Data and Computer Software... Noncommercial Computer Software and Noncommercial Computer Software Documentation, when the Government requires...

48 CFR 227.7203-17 - Overseas contracts with foreign sources.

Code of Federal Regulations, 2014 CFR

2014-10-01

... COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-17 Overseas contracts with foreign sources. (a) The clause at 252.227-7032, Rights in Technical Data and Computer Software... Noncommercial Computer Software and Noncommercial Computer Software Documentation, when the Government requires...

48 CFR 227.7203-17 - Overseas contracts with foreign sources.

Code of Federal Regulations, 2011 CFR

2011-10-01

... COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-17 Overseas contracts with foreign sources. (a) The clause at 252.227-7032, Rights in Technical Data and Computer Software... Noncommercial Computer Software and Noncommercial Computer Software Documentation, when the Government requires...

48 CFR 227.7203-17 - Overseas contracts with foreign sources.

Code of Federal Regulations, 2012 CFR

2012-10-01

... COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-17 Overseas contracts with foreign sources. (a) The clause at 252.227-7032, Rights in Technical Data and Computer Software... Noncommercial Computer Software and Noncommercial Computer Software Documentation, when the Government requires...

Dynamics of nonautonomous rogue waves in Bose-Einstein condensate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao, Li-Chen, E-mail: zhaolichen3@163.com

2013-02-15

We study rogue waves of Bose-Einstein condensate (BEC) analytically in a time-dependent harmonic trap with a complex potential. Properties of the nonautonomous rogue waves are investigated analytically. It is reported that there are possibilities to 'catch' rogue waves through manipulating nonlinear interaction properly. The results provide many possibilities to manipulate rogue waves experimentally in a BEC system. - Highlights: Black-Right-Pointing-Pointer One more generalized rogue wave solutions are presented. Black-Right-Pointing-Pointer Present one possible way to catch a rouge wave. Black-Right-Pointing-Pointer Properties of rogue waves are investigated analytically for the first time. Black-Right-Pointing-Pointer Provide many possibilities to manipulate rogue waves in BEC.

Quantum synchronization of chaotic oscillator behaviors among coupled BEC-optomechanical systems

NASA Astrophysics Data System (ADS)

Li, Wenlin; Li, Chong; Song, Heshan

2017-03-01

We consider and theoretically analyze a Bose-Einstein condensate (BEC) trapped inside an optomechanical system consisting of single-mode optical cavity with a moving end mirror. The BEC is formally analogous to a mirror driven by radiation pressure with strong nonlinear coupling. Such a nonlinear enhancement can make the oscillator display chaotic behavior. By establishing proper oscillator couplings, we find that this chaotic motion can be synchronized with other oscillators, even an oscillator network. We also discuss the scheme feasibility by analyzing recent experiment parameters. Our results provide a promising platform for the quantum signal transmission and quantum logic control, and they are of potential applications in quantum information processing and quantum networks.

Non-equilibrium Properties of a Pumped-Decaying Bose-Condensed Electron–Hole Gas in the BCS–BEC Crossover Region

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hanai, R.; Littlewood, P. B.; Ohashi, Y.

2016-03-01

We theoretically investigate a Bose-condensed exciton gas out of equilibrium. Within the framework of the combined BCS-Leggett strong-coupling theory with the non-equilibrium Keldysh formalism, we show how the Bose-Einstein condensation (BEC) of excitons is suppressed to eventually disappear, when the system is in the non-equilibrium steady state. The supply of electrons and holes from the bath is shown to induce quasi-particle excitations, leading to the partial occupation of the upper branch of Bogoliubov single-particle excitation spectrum. We also discuss how this quasi-particle induction is related to the suppression of exciton BEC, as well as the stability of the steady state.

Fifteen years of cold matter on the atom chip: promise, realizations, and prospects

PubMed Central

Keil, Mark; Amit, Omer; Zhou, Shuyu; Groswasser, David; Japha, Yonathan; Folman, Ron

2016-01-01

Here we review the field of atom chips in the context of Bose–Einstein Condensates (BEC) as well as cold matter in general. Twenty years after the first realization of the BEC and 15 years after the realization of the atom chip, the latter has been found to enable extraordinary feats: from producing BECs at a rate of several per second, through the realization of matter-wave interferometry, and all the way to novel probing of surfaces and new forces. In addition, technological applications are also being intensively pursued. This review will describe these developments and more, including new ideas which have not yet been realized. PMID:27499585

The Pedagogical Practices of Québec High School Teachers Relative to Sexual Diversity

ERIC Educational Resources Information Center

Richard, Gabrielle

2015-01-01

This article explores the ways in which teachers describe their pedagogical and intervention practices relative to sexual diversity in Québec (Canada). Three variables closely associated with teachers who report inclusive practices emerge: experiential training (based on the experience of a lesbian, gay, or bisexual [LGB] teacher), contact…

Economic Understanding and BEC National Level Students. Research Papers in Economics Education.

ERIC Educational Resources Information Center

King, Barrie

The implementation of a unified national system of non-degree courses in business administration, the Business Economic Council (BEC) courses, replaced the ordinary national diploma and certificate courses in business administration in British colleges in the 1970's. Widespread faculty concern that these new courses have not been providing…

Thinking Interculturally: Decolonizing History and Citizenship Education in Québec

ERIC Educational Resources Information Center

DesRoches, Sarah J.

2016-01-01

The main objective of this article is to offer an alternative discursive framework for teaching history and citizenship education in Québec, Canada. Enabling a more inclusive discussion around how citizenship is constructed, thinking interculturally allows us begin thinking about practical ways in which citizenship and history education might…

Shock Waves in a Bose-Einstein Condensate

NASA Technical Reports Server (NTRS)

Kulikov, Igor; Zak, Michail

2005-01-01

A paper presents a theoretical study of shock waves in a trapped Bose-Einstein condensate (BEC). The mathematical model of the BEC in this study is a nonlinear Schroedinger equation (NLSE) in which (1) the role of the wave function of a single particle in the traditional Schroedinger equation is played by a space- and time-dependent complex order parameter (x,t) proportional to the square root of the density of atoms and (2) the atoms engage in a repulsive interaction characterized by a potential proportional to | (x,t)|2. Equations that describe macroscopic perturbations of the BEC at zero temperature are derived from the NLSE and simplifying assumptions are made, leading to equations for the propagation of sound waves and the transformation of sound waves into shock waves. Equations for the speeds of shock waves and the relationships between jumps of velocity and density across shock fronts are derived. Similarities and differences between this theory and the classical theory of sound waves and shocks in ordinary gases are noted. The present theory is illustrated by solving the equations for the example of a shock wave propagating in a cigar-shaped BEC.

Superfluid density of states and pseudogap phenomenon in the BCS-BEC crossover regime of a superfluid Fermi gas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Watanabe, Ryota; Tsuchiya, Shunji; CREST

2010-10-15

We investigate single-particle excitations and strong-coupling effects in the BCS-BEC crossover regime of a superfluid Fermi gas. Including phase and amplitude fluctuations of the superfluid order parameter within a T-matrix theory, we calculate the superfluid density of states (DOS), as well as single-particle spectral weight, over the entire BCS-BEC crossover region below the superfluid transition temperature T{sub c}. We clarify how the pseudogap in the normal state evolves into the superfluid gap, as one passes through T{sub c}. While the pseudogap in DOS continuously evolves into the superfluid gap in the weak-coupling BCS regime, the superfluid gap in the crossovermore » region is shown to appear in DOS after the pseudogap disappears below T{sub c}. In the phase diagram with respect to the temperature and interaction strength, we determine the region where strong pairing fluctuations dominate over single-particle properties of the system. Our results would be useful for the study of strong-coupling phenomena in the BCS-BEC crossover regime of a superfluid Fermi gas.« less

Novel LRPPRC Mutation in a Boy With Mild Leigh Syndrome, French-Canadian Type Outside of Québec.

PubMed

Han, Velda Xinying; Tan, Teresa S; Wang, Furene S; Tay, Stacey Kiat-Hong

2017-01-01

Leigh syndrome, French-Canadian type is unique to patients from a genetic isolate in the Saguenay-Lac-Saint-Jean region of Québec. It has also been recently described in 10 patients with LRPPRC mutation outside of Québec. It is an autosomal recessive genetic disorder with fatal metabolic crisis and severe neurological morbidity in infancy caused by LRPPRC mutation. The authors report a boy with a novel LRPPRC compound heterozygous missense mutations c.3130C>T, c.3430C>T, and c.4078G>A found on whole-exome sequencing which correlated with isolated cytochrome c-oxidase deficiency found in skeletal muscle. LRPPRC mutation is a rare cause of cytochrome c-oxidase-deficient form of Leigh syndrome outside of Québec. Our patient broadens the spectrum of phenotypes of Leigh syndrome, French-Canadian type. LRPPRC mutation should be considered in children with early childhood neurodegenerative disorder, even in the absence of metabolic crisis. Early evaluation with whole-exome sequencing is useful for early diagnosis and for genetic counseling.

An effective public health program to reduce urban heat islands in Québec, Canada.

PubMed

Beaudoin, Mélanie; Gosselin, Pierre

2016-09-01

In 2005, the Government of the Province of Québec, Canada, adopted the Climate Change Action Plan for 2006 - 2012. The Institut national de santé publique du Québec (National Institute of Public Health of Québec), charged with implementing the health adaptation component of the Plan, worked to mitigate urban heat islands (UHI) by funding and evaluating 40 pilot projects. These projects explored different methods of fighting UHIs by greening cities in a participative and mobilizing approach led mainly by non-governmental organizations and municipalities. An assessment of temperatures before and after implementing various methods demonstrated that some actions enabled significant gains of coolness and more efficiently mitigated heat (reduction of concrete/asphalt surfaces, increasing vegetation, etc.). An assessment of quality of life showed that projects were positively received by users, especially by those living in vulnerable situations. A lifecycle analysis showed that from the environmental perspective, UHI mitigation measures that do not require fertilization or maintenance are preferable. Finally, communication efforts that raise awareness of UHI and mitigation are of significant importance to program success.

Nonlinear Dynamics of Multi-Component Bose-Einstein Condensates ---Anti-Gravity Transport and Vortex Chaos---

NASA Astrophysics Data System (ADS)

Nakamura, K.

Bose-Einstein condensate(BEC) provides a nice stage when the nonlinearSchrödinger equation plays a vital role. We study the dynamics of multi-component repulsive BEC in 2 dimensions with harmonic traps by using the nonlinear Schrödinger (or Gross-Pitaevskii) equation. Firstly we consider a driven two-component BEC with each component trapped in different vertical positions. The appropriate tuning of the oscillation frequency of the magnetic field leads to a striking anti-gravity transport of BEC. This phenomenon is a manifestation of macroscopic non-adiabatic tunneling in a system with two internal(electronic) degrees of freedom. The dynamics splits into a fast complex spatio-temporal oscillation of each condensate wavefunctions together with a slow levitation of the total center of mass. Secondly, we examine the three-component repulsive BEC in 2 dimensions in a harmonic trap in the absence of magnetic field, and construct a model of conservative chaos based on a picture of vortex molecules. We obtain an effective nonlinear dynamics for three vortex cores, which represents three charged particles under the uniform magnetic field with the repulsive inter-particle potential quadratic in the inter-vortex distance r_{ij} on short scale and logarithmic in r_{ij} on large scale. The vortices here acquire the inertia in marked contrast to the standard theory of point vortices since Onsager. We then explore ``the chaos in the three-body problem" in the context of vortices with inertia.

Superfluid density and condensate fraction in the BCS-BEC crossover regime at finite temperatures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fukushima, N.; Ohashi, Y.; Faculty of Science and Technology, Keio University, Hiyoshi, Yokohama 223

2007-03-15

The superfluid density is a fundamental quantity describing the response to a rotation as well as in two-fluid collisional hydrodynamics. We present extensive calculations of the superfluid density {rho}{sub s} in the BCS-BEC crossover regime of a uniform superfluid Fermi gas at finite temperatures. We include strong-coupling or fluctuation effects on these quantities within a Gaussian approximation. We also incorporate the same fluctuation effects into the BCS single-particle excitations described by the superfluid order parameter {delta} and Fermi chemical potential {mu}, using the Nozieres-Schmitt-Rink approximation. This treatment is shown to be necessary for consistent treatment of {rho}{sub s} over themore » entire BCS-BEC crossover. We also calculate the condensate fraction N{sub c} as a function of the temperature, a quantity which is quite different from the superfluid density {rho}{sub s}. We show that the mean-field expression for the condensate fraction N{sub c} is a good approximation even in the strong-coupling BEC regime. Our numerical results show how {rho}{sub s} and N{sub c} depend on temperature, from the weak-coupling BCS region to the BEC region of tightly bound Cooper pair molecules. In a companion paper [Phys. Rev. A 74, 063626 (2006)], we derive an equivalent expression for {rho}{sub s} from the thermodynamic potential, which exhibits the role of the pairing fluctuations in a more explicit manner.« less

48 CFR 252.227-7027 - Deferred ordering of technical data or computer software.

Code of Federal Regulations, 2013 CFR

2013-10-01

... technical data or computer software. 252.227-7027 Section 252.227-7027 Federal Acquisition Regulations... data or computer software. As prescribed at 227.7103-8(b), use the following clause: Deferred Ordering of Technical Data or Computer Software (APR 1988) In addition to technical data or computer software...

48 CFR 252.227-7027 - Deferred ordering of technical data or computer software.

Code of Federal Regulations, 2011 CFR

2011-10-01

... technical data or computer software. 252.227-7027 Section 252.227-7027 Federal Acquisition Regulations... data or computer software. As prescribed at 227.7103-8(b), use the following clause: Deferred Ordering of Technical Data or Computer Software (APR 1988) In addition to technical data or computer software...

48 CFR 252.227-7027 - Deferred ordering of technical data or computer software.

Code of Federal Regulations, 2012 CFR

2012-10-01

... technical data or computer software. 252.227-7027 Section 252.227-7027 Federal Acquisition Regulations... data or computer software. As prescribed at 227.7103-8(b), use the following clause: Deferred Ordering of Technical Data or Computer Software (APR 1988) In addition to technical data or computer software...

48 CFR 252.227-7027 - Deferred ordering of technical data or computer software.

Code of Federal Regulations, 2014 CFR

2014-10-01

... technical data or computer software. 252.227-7027 Section 252.227-7027 Federal Acquisition Regulations... data or computer software. As prescribed at 227.7103-8(b), use the following clause: Deferred Ordering of Technical Data or Computer Software (APR 1988) In addition to technical data or computer software...

48 CFR 252.227-7027 - Deferred ordering of technical data or computer software.

Code of Federal Regulations, 2010 CFR

2010-10-01

... technical data or computer software. 252.227-7027 Section 252.227-7027 Federal Acquisition Regulations... data or computer software. As prescribed at 227.7103-8(b), use the following clause: Deferred Ordering of Technical Data or Computer Software (APR 1988) In addition to technical data or computer software...

Improved Method for the Establishment of an In Vitro Blood-Brain Barrier Model Based on Porcine Brain Endothelial Cells.

PubMed

Nielsen, Simone S E; Siupka, Piotr; Georgian, Ana; Preston, Jane E; Tóth, Andrea E; Yusof, Siti R; Abbott, N Joan; Nielsen, Morten S

2017-09-24

The aim of this protocol presents an optimized procedure for the purification and cultivation of pBECs and to establish in vitro blood-brain barrier (BBB) models based on pBECs in mono-culture (MC), MC with astrocyte-conditioned medium (ACM), and non-contact co-culture (NCC) with astrocytes of porcine or rat origin. pBECs were isolated and cultured from fragments of capillaries from the brain cortices of domestic pigs 5-6 months old. These fragments were purified by careful removal of meninges, isolation and homogenization of grey matter, filtration, enzymatic digestion, and centrifugation. To further eliminate contaminating cells, the capillary fragments were cultured with puromycin-containing medium. When 60-95% confluent, pBECs growing from the capillary fragments were passaged to permeable membrane filter inserts and established in the models. To increase barrier tightness and BBB characteristic phenotype of pBECs, the cells were treated with the following differentiation factors: membrane permeant 8-CPT-cAMP (here abbreviated cAMP), hydrocortisone, and a phosphodiesterase inhibitor, RO-20-1724 (RO). The procedure was carried out over a period of 9-11 days, and when establishing the NCC model, the astrocytes were cultured 2-8 weeks in advance. Adherence to the described procedures in the protocol has allowed the establishment of endothelial layers with highly restricted paracellular permeability, with the NCC model showing an average transendothelial electrical resistance (TEER) of 1249 ± 80 Ω cm 2 , and paracellular permeability (Papp) for Lucifer Yellow of 0.90 10 -6 ± 0.13 10 -6 cm sec -1 (mean ± SEM, n=55). Further evaluation of this pBEC phenotype showed good expression of the tight junctional proteins claudin 5, ZO-1, occludin and adherens junction protein p120 catenin. The model presented can be used for a range of studies of the BBB in health and disease and, with the highly restrictive paracellular permeability, this model is suitable for studies of transport and intracellular trafficking.

Broncho Vaxom (OM-85) modulates rhinovirus docking proteins on human airway epithelial cells via Erk1/2 mitogen activated protein kinase and cAMP

PubMed Central

Pasquali, Christian; Stolz, Daiana; Tamm, Michael

2017-01-01

Background Bronchial epithelial cells (BEC) are primary target for Rhinovirus infection through attaching to cell membrane proteins. OM-85, a bacterial extract, improves recovery of asthma and COPD patients after viral infections, but only part of the mechanism was addressed, by focusing on defined immune cells. Objective We therefore determined the effect of OM-85 on isolated primary human BEC of controls (n = 8), asthma patients (n = 10) and COPD patients (n = 9). Methods BEC were treated with OM-85 alone (24 hours) or infected with Rhinovirus. BEC survival was monitored by manual cell counting and Rhinovirus replication by lytic activity. Immuno-blotting and ELISA were used to determine the expression of Rhinovirus interacting proteins: intracellular adhesion molecule (ICAM), major histocompatibility complex class II (MHC-2), complement component C1q receptor (C1q-R), inducible T-Cell co-stimulator (ICOS), its ligand ICOSL, and myeloid differentiation primary response gene 88 (Myd88); as well as for signal transducers Erk1/2, p38, JNK mitogen activated protein kinases MAPK), and cAMP. Results OM-85 significantly reduced Rhinovirus-induced BEC death and virus replication. OM-85 significantly increased the expression of virus interacting proteins C1q-R and β-defensin in all 3 probes and groups, which was prevented by either Erk1/2 MAPK or cAMP inhibition. In addition, OM-85 significantly reduced Rhinovirus induced expression of ICAM1 involving p38 MAPK. In BEC OM-85 had no significant effect on the expression of ICOS, ICOSL and MHC-2 membrane proteins nor on the adaptor protein MyD88. Conclusion The OM-85-induced increased of C1q-R and β-defensin, both important for antigen presentation and phagocytosis, supports its activity in host cell’s defence against Rhinovirus infection. PMID:29182620

Broncho Vaxom (OM-85) modulates rhinovirus docking proteins on human airway epithelial cells via Erk1/2 mitogen activated protein kinase and cAMP.

PubMed

Roth, Michael; Pasquali, Christian; Stolz, Daiana; Tamm, Michael

2017-01-01

Bronchial epithelial cells (BEC) are primary target for Rhinovirus infection through attaching to cell membrane proteins. OM-85, a bacterial extract, improves recovery of asthma and COPD patients after viral infections, but only part of the mechanism was addressed, by focusing on defined immune cells. We therefore determined the effect of OM-85 on isolated primary human BEC of controls (n = 8), asthma patients (n = 10) and COPD patients (n = 9). BEC were treated with OM-85 alone (24 hours) or infected with Rhinovirus. BEC survival was monitored by manual cell counting and Rhinovirus replication by lytic activity. Immuno-blotting and ELISA were used to determine the expression of Rhinovirus interacting proteins: intracellular adhesion molecule (ICAM), major histocompatibility complex class II (MHC-2), complement component C1q receptor (C1q-R), inducible T-Cell co-stimulator (ICOS), its ligand ICOSL, and myeloid differentiation primary response gene 88 (Myd88); as well as for signal transducers Erk1/2, p38, JNK mitogen activated protein kinases MAPK), and cAMP. OM-85 significantly reduced Rhinovirus-induced BEC death and virus replication. OM-85 significantly increased the expression of virus interacting proteins C1q-R and β-defensin in all 3 probes and groups, which was prevented by either Erk1/2 MAPK or cAMP inhibition. In addition, OM-85 significantly reduced Rhinovirus induced expression of ICAM1 involving p38 MAPK. In BEC OM-85 had no significant effect on the expression of ICOS, ICOSL and MHC-2 membrane proteins nor on the adaptor protein MyD88. The OM-85-induced increased of C1q-R and β-defensin, both important for antigen presentation and phagocytosis, supports its activity in host cell's defence against Rhinovirus infection.

The Ne3LS Network, Québec's initiative to evaluate the impact and promote a responsible and sustainable development of nanotechnology

NASA Astrophysics Data System (ADS)

Endo, Charles-Anica; Emond, Claude; Battista, Renaldo; Parizeau, Marie-Hélène; Beaudry, Catherine

2011-07-01

The spectacular progress made by nanosciences and nanotechnologies elicits as much hope and fear. Consequently, a great number of research and training initiatives on the ethical, environmental, economic, legal and social issues regarding nanotechnology development (Ne3LS) are emerging worldwide. In Québec, Canada, a Task Force was mandated by NanoQuébec to conceive a Ne3LS research and training strategy to assess those issues. This Task Force brought together experts from universities, governments or industry working in nanosciences and nanotechnologies or in Ne3LS. Their resulting action plan, made public in November 2006, contained several recommendations, including the creation of a knowledge network (Ne3LS Network). In the following years, after consulting with numerous key players concerned with the possible impacts of nanosciences and nanotechnologies in Québec, the Ne3LS Network was launched in January 2010 in partnership with the Fonds québécois de la recherche sur la nature et les technologies, the Fonds québécois de la recherche sur la société et la culture and the Fonds de la recherche en santé du Québec, NanoQuébec, the Institut de recherche Robert-Sauvé en santé et en sécurité du travail as well as the University of Montreal. Its objectives are to 1) Foster the development of Ne3LS research activities (grants and fellowships); 2) Spearhead the Canadian and international Ne3LS network; 3) Take part in the training of researchers and experts; 4) Encourage the creation of interactive tools for the general public; 5) Facilitate collaboration between decision-makers and experts; 6) Involve the scientific community through a host of activities (symposium, conferences, thematic events); 7) Build multidisciplinary research teams to evaluate the impact of nanotechnology.

Alpha-, gamma- and delta-tocopherols reduce inflammatory angiogenesis in human microvascular endothelial cells.

PubMed

Wells, Shannon R; Jennings, Merilyn H; Rome, Courtney; Hadjivassiliou, Vicky; Papas, Konstantinos A; Alexander, Jonathon S

2010-07-01

Vitamin E, a micronutrient (comprising alpha-, beta-, gamma- and delta-tocopherols, alpha-, beta-, gamma- and delta-tocotrienols), has documented antioxidant and non-antioxidant effects, some of which inhibit inflammation and angiogenesis. We compared the abilities of alpha-, gamma- and delta-tocopherols to regulate human blood cytotoxicity (BEC) and lymphatic endothelial cytotoxicity (LEC), proliferation, invasiveness, permeability, capillary formation and suppression of TNF-alpha-induced VCAM-1 as in vitro models of inflammatory angiogenesis. alpha-, gamma- and delta-tocopherols were not toxic to either cell type up to 40 microM. In BEC, confluent cell density was decreased by all concentrations of delta- and gamma-tocopherol (10-40 microM) but not by alpha-tocopherol. LEC showed no change in cell density in response to tocopherols. delta-Tocopherol (40 microM), but not other isomers, decreased BEC invasiveness. In LEC, all doses of gamma-tocopherol, as well as the highest dose of alpha-tocopherol (40 microM), decreased cell invasiveness. delta-Tocopherol had no effect on LEC invasiveness at any molarity. delta-Tocopherol dose dependently increased cell permeability at 48 h in BEC and LEC; alpha- and gamma-tocopherols showed slight effects. Capillary tube formation was decreased by high dose (40 microM) concentrations of alpha-, gamma- and delta-tocopherol, but showed no effects with smaller doses (10-20 microM) in BEC. gamma-Tocopherol (10-20 microM) and alpha-tocopherol (10 microM), but not delta-tocopherol, increased LEC capillary tube formation. Lastly, in BEC, alpha-, gamma- and delta-tocopherol each dose-dependently reduced TNF-alpha-induced expression of VCAM-1. In LEC, there was no significant change to TNF-alpha-induced VCAM-1 expression with any concentration of alpha-, gamma- or delta-tocopherol. These data demonstrate that physiological levels (0-40 microM) of alpha-, gamma- and delta-tocopherols are nontoxic and dietary tocopherols, especially delta-tocopherol, can limit several BEC and LEC endothelial behaviors associated with angiogenesis. Tocopherols may therefore represent important nutrient-signals that limit cell behaviors related to inflammation/angiogenesis, which when deficient, may predispose individuals to risks associated with elevated angiogenesis such as inflammation and cancer; further differences seen from the tocopherols may be due to their blood or lymphatic cell origin. (c) 2010 Elsevier Inc. All rights reserved.

Variation spatiotemporelle de la cryptorchidie et de l’hypospadias au Québec : Une étude exploratoire

PubMed Central

Guertin, Sophie; Lemieux, Karine-Sylvie; Makhoulian, Natalie; Michaud, Sébastien; Patry, Rose-Marie; Côté, Anne-Andrée; Gagnon, Fabien; Ayotte, Pierre; Bolduc, Stéphane

2011-01-01

Résumé Objectifs : La majorité des études effectuées au cours des dernières décennies ont mis en évidence une augmentation du nombre de cas de cryptorchidie et d’hypospadias entre 1970 et 1990. De plus, l’importante variabilité géographique de ces anomalies est bien décrite. Cette étude vise à mesurer la prévalence à la naissance de la cryptorchidie et de l’hypospadias au Québec, à vérifier si ces anomalies sont en augmentation et à en évaluer la répartition interrégionale. Méthode : Une étude épidémiologique descriptive a été réalisée à partir du nombre de garçons de cinq ans et moins hospitalisés pour une cryptorchidie ou un hypospadias au Québec de 1989 à 2004 selon les données du fichier administratif d’hospitalisation MED-ÉCHO. Les données sur les naissances provenaient de l’Institut de la statistique du Québec. Résultats : La prévalence annuelle moyenne pour 1000 naissances vivantes de sexe masculin est de 19,1 (IC à 95 % : 18,8–19,4) pour la cryptorchidie et 11,4 (IC à 95 % 11,1–11,6) pour l’hypospadias au Québec. Au cours de la période étudiée, la prévalence de cryptorchidie a légèrement diminué, alors que celle de l’hypospadias est demeurée stable. Comparativement à la province du Québec, des régions présentent une prévalence significativement différente de cryptorchidie et/ou d’hypospadias. . Conclusion : Au Québec, la prévalence de cryptorchidie est en légère diminution alors que celle de l’hypospadias est stable. Des variations régionales significatives sont observables. D’autres études sont nécessaires afin d’évaluer l’hypothèse d’un lien avec les contaminants environnementaux en émergence. L’implantation d’un système de surveillance des anomalies congénitales permettrait une représentation plus valide de la situation. PMID:21672476

Variation spatiotemporelle de la cryptorchidie et de l'hypospadias au Québec : Une étude exploratoire.

PubMed

Guertin, Sophie; Lemieux, Karine-Sylvie; Makhoulian, Natalie; Michaud, Sébastien; Patry, Rose-Marie; Côté, Anne-Andrée; Gagnon, Fabien; Ayotte, Pierre; Bolduc, Stéphane

2011-06-01

RéSUMé: : La majorité des études effectuées au cours des dernières décennies ont mis en évidence une augmentation du nombre de cas de cryptorchidie et d'hypospadias entre 1970 et 1990. De plus, l'importante variabilité géographique de ces anomalies est bien décrite. Cette étude vise à mesurer la prévalence à la naissance de la cryptorchidie et de l'hypospadias au Québec, à vérifier si ces anomalies sont en augmentation et à en évaluer la répartition interrégionale. MéTHODE :: Une étude épidémiologique descriptive a été réalisée à partir du nombre de garçons de cinq ans et moins hospitalisés pour une cryptorchidie ou un hypospadias au Québec de 1989 à 2004 selon les données du fichier administratif d'hospitalisation MED-ÉCHO. Les données sur les naissances provenaient de l'Institut de la statistique du Québec. RéSULTATS :: La prévalence annuelle moyenne pour 1000 naissances vivantes de sexe masculin est de 19,1 (IC à 95 % : 18,8-19,4) pour la cryptorchidie et 11,4 (IC à 95 % 11,1-11,6) pour l'hypospadias au Québec. Au cours de la période étudiée, la prévalence de cryptorchidie a légèrement diminué, alors que celle de l'hypospadias est demeurée stable. Comparativement à la province du Québec, des régions présentent une prévalence significativement différente de cryptorchidie et/ou d'hypospadias. . : Au Québec, la prévalence de cryptorchidie est en légère diminution alors que celle de l'hypospadias est stable. Des variations régionales significatives sont observables. D'autres études sont nécessaires afin d'évaluer l'hypothèse d'un lien avec les contaminants environnementaux en émergence. L'implantation d'un système de surveillance des anomalies congénitales permettrait une représentation plus valide de la situation.

SITELLE's Data Release 1

NASA Astrophysics Data System (ADS)

Martin, T. B.; Drissen, L.

2016-12-01

Installed at the Canada-France-Hawaii Telescope (CFHT) since August 2015, SITELLE is an Imaging Fourier Transform Spectrometer (IFTS) with an 11×11 field of view. After its prototype SpIOMM, installed at Mont Mégantic (Québec, Canada), it is the second IFTS in the world operating in the visible band (350-1000 nm). It delivers hyperspectral data cubes of 4 million spectra at R˜1500-5000 with a spatial sampling of 0.32" and a filling factor of 100 %. A suite of softwares has been designed to reduce (ORBS) and analyze (ORCS) the data. Based on commissioning data obtained in August 2015, a first stable version has been released in March 2016 which is capable of reducing all the data. In this paper the quality of the calibration is discussed.

48 CFR 227.7203-1 - Policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-1 Policy. (a) DoD policy is to acquire only the computer software and computer software documentation, and the rights in such software or documentation, necessary...

48 CFR 227.7203-1 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-1 Policy. (a) DoD policy is to acquire only the computer software and computer software documentation, and the rights in such software or documentation, necessary...

48 CFR 227.7203-1 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-1 Policy. (a) DoD policy is to acquire only the computer software and computer software documentation, and the rights in such software or documentation, necessary...

48 CFR 227.7203-1 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-1 Policy. (a) DoD policy is to acquire only the computer software and computer software documentation, and the rights in such software or documentation, necessary...

48 CFR 227.7203-1 - Policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-1 Policy. (a) DoD policy is to acquire only the computer software and computer software documentation, and the rights in such software or documentation, necessary...

48 CFR 227.7205 - Contracts for special works.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Computer Software and Computer Software Documentation 227.7205 Contracts for special works. (a) Use the... a specific need to control the distribution of computer software or computer software documentation..., modification, reproduction, release, performance, display, or disclosure of such software or documentation. Use...

48 CFR 227.7205 - Contracts for special works.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Computer Software and Computer Software Documentation 227.7205 Contracts for special works. (a) Use the... a specific need to control the distribution of computer software or computer software documentation..., modification, reproduction, release, performance, display, or disclosure of such software or documentation. Use...

FIRST Quantum-(1980)-Computing DISCOVERY in Siegel-Rosen-Feynman-...A.-I. Neural-Networks: Artificial(ANN)/Biological(BNN) and Siegel FIRST Semantic-Web and Siegel FIRST ``Page''-``Brin'' ``PageRank'' PRE-Google Search-Engines!!!

NASA Astrophysics Data System (ADS)

Rosen, Charles; Siegel, Edward Carl-Ludwig; Feynman, Richard; Wunderman, Irwin; Smith, Adolph; Marinov, Vesco; Goldman, Jacob; Brine, Sergey; Poge, Larry; Schmidt, Erich; Young, Frederic; Goates-Bulmer, William-Steven; Lewis-Tsurakov-Altshuler, Thomas-Valerie-Genot; Ibm/Exxon Collaboration; Google/Uw Collaboration; Microsoft/Amazon Collaboration; Oracle/Sun Collaboration; Ostp/Dod/Dia/Nsa/W.-F./Boa/Ubs/Ub Collaboration

2013-03-01

Belew[Finding Out About, Cambridge(2000)] and separately full-decade pre-Page/Brin/Google FIRST Siegel-Rosen(Machine-Intelligence/Atherton)-Feynman-Smith-Marinov(Guzik Enterprises/Exxon-Enterprises/A.-I./Santa Clara)-Wunderman(H.-P.) [IBM Conf. on Computers and Mathematics, Stanford(1986); APS Mtgs.(1980s): Palo Alto/Santa Clara/San Francisco/...(1980s) MRS Spring-Mtgs.(1980s): Palo Alto/San Jose/San Francisco/...(1980-1992) FIRST quantum-computing via Bose-Einstein quantum-statistics(BEQS) Bose-Einstein CONDENSATION (BEC) in artificial-intelligence(A-I) artificial neural-networks(A-N-N) and biological neural-networks(B-N-N) and Siegel[J. Noncrystalline-Solids 40, 453(1980); Symp. on Fractals..., MRS Fall-Mtg., Boston(1989)-5-papers; Symp. on Scaling..., (1990); Symp. on Transport in Geometric-Constraint (1990)

48 CFR 227.7203-6 - Contract clauses.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Software and Computer Software Documentation 227.7203-6 Contract clauses. (a)(1) Use the clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation, in solicitations and contracts when the successful offeror(s) will be required to deliver computer software or...

48 CFR 227.7203-6 - Contract clauses.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Software and Computer Software Documentation 227.7203-6 Contract clauses. (a)(1) Use the clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation, in solicitations and contracts when the successful offeror(s) will be required to deliver computer software or...

48 CFR 227.7203-6 - Contract clauses.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Software and Computer Software Documentation 227.7203-6 Contract clauses. (a)(1) Use the clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation, in solicitations and contracts when the successful offeror(s) will be required to deliver computer software or...

48 CFR 227.7203-6 - Contract clauses.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Software and Computer Software Documentation 227.7203-6 Contract clauses. (a)(1) Use the clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation, in solicitations and contracts when the successful offeror(s) will be required to deliver computer software or...

48 CFR 227.7203-6 - Contract clauses.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Software and Computer Software Documentation 227.7203-6 Contract clauses. (a)(1) Use the clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation, in solicitations and contracts when the successful offeror(s) will be required to deliver computer software or...

Benefits and Challenges of Information and Communication Technologies (ICT) Integration in Québec English Schools

ERIC Educational Resources Information Center

Rabah, Jihan

2015-01-01

This paper investigated teachers' and educational consultants' perceptions of ICT integration in Québec English Schools, specifically with regards to the benefits and challenges of ICT integration therein. 23 teachers and educational consultants from seven different school boards participated in the focus group sessions. Results revealed higher…

[10 years of feminist intervention in Quebec: statement and perspectives].

PubMed

Bourgon, M; Corbeil, C

1990-05-01

The authors start off by reviewing the origins and principal characteristics of feminist therapy as it appeared in the United States at the end of the 1960s. Following this step are analyzed the conditions for the emergence of feminist intervention in Québec and its specificity, terms commonly used by Québec practicians when describing their work among women. Emphasis is placed on the analysis of feminist intervention in institutional environments due to its remarkable development over the last few years. The article concisely presents the two main theoretical approaches that inspire the intervention, namely the socio-behavioral approach and the awareness approach. Following a brief overview of feminist intervention in Québec, the authors raise questions about its future.

48 CFR 52.227-14 - Rights in Data-General.

Code of Federal Regulations, 2010 CFR

2010-10-01

... software. Computer software—(1) Means (i) Computer programs that comprise a series of instructions, rules... or computer software documentation. Computer software documentation means owner's manuals, user's... medium, that explain the capabilities of the computer software or provide instructions for using the...

48 CFR 227.7203-9 - Copyright.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Software and Computer Software Documentation 227.7203-9 Copyright. (a) Copyright license. (1) The clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software... Government to reproduce the software or documentation, distribute copies, perform or display the software or...

48 CFR 227.7203-9 - Copyright.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Software and Computer Software Documentation 227.7203-9 Copyright. (a) Copyright license. (1) The clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software... Government to reproduce the software or documentation, distribute copies, perform or display the software or...

48 CFR 227.7203-9 - Copyright.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Software and Computer Software Documentation 227.7203-9 Copyright. (a) Copyright license. (1) The clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software... Government to reproduce the software or documentation, distribute copies, perform or display the software or...

48 CFR 227.7203-9 - Copyright.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Software and Computer Software Documentation 227.7203-9 Copyright. (a) Copyright license. (1) The clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software... Government to reproduce the software or documentation, distribute copies, perform or display the software or...

48 CFR 227.7203-9 - Copyright.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Software and Computer Software Documentation 227.7203-9 Copyright. (a) Copyright license. (1) The clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software... Government to reproduce the software or documentation, distribute copies, perform or display the software or...

48 CFR 227.7203-13 - Government right to review, verify, challenge and validate asserted restrictions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227..., reproduce, release, or disclose computer software or computer software documentation do not, by themselves, determine the extent of the Government's rights in such software or documentation. The Government may...

48 CFR 227.7203-13 - Government right to review, verify, challenge and validate asserted restrictions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227..., reproduce, release, or disclose computer software or computer software documentation do not, by themselves, determine the extent of the Government's rights in such software or documentation. The Government may...

48 CFR 227.7203-13 - Government right to review, verify, challenge and validate asserted restrictions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227..., reproduce, release, or disclose computer software or computer software documentation do not, by themselves, determine the extent of the Government's rights in such software or documentation. The Government may...

48 CFR 227.7203-13 - Government right to review, verify, challenge and validate asserted restrictions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227..., reproduce, release, or disclose computer software or computer software documentation do not, by themselves, determine the extent of the Government's rights in such software or documentation. The Government may...

48 CFR 227.7203-13 - Government right to review, verify, challenge and validate asserted restrictions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227..., reproduce, release, or disclose computer software or computer software documentation do not, by themselves, determine the extent of the Government's rights in such software or documentation. The Government may...

Computer software.

PubMed

Rosenthal, L E

1986-10-01

Software is the component in a computer system that permits the hardware to perform the various functions that a computer system is capable of doing. The history of software and its development can be traced to the early nineteenth century. All computer systems are designed to utilize the "stored program concept" as first developed by Charles Babbage in the 1850s. The concept was lost until the mid-1940s, when modern computers made their appearance. Today, because of the complex and myriad tasks that a computer system can perform, there has been a differentiation of types of software. There is software designed to perform specific business applications. There is software that controls the overall operation of a computer system. And there is software that is designed to carry out specialized tasks. Regardless of types, software is the most critical component of any computer system. Without it, all one has is a collection of circuits, transistors, and silicone chips.

48 CFR 227.7202-1 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7202-1 Policy. (a) Commercial computer software or commercial computer software documentation shall be acquired under the licenses customarily provided to the public...

48 CFR 227.7202-1 - Policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7202-1 Policy. (a) Commercial computer software or commercial computer software documentation shall be acquired under the licenses customarily provided to the public...

48 CFR 227.7202-1 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7202-1 Policy. (a) Commercial computer software or commercial computer software documentation shall be acquired under the licenses customarily provided to the public...

48 CFR 227.7202-1 - Policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7202-1 Policy. (a) Commercial computer software or commercial computer software documentation shall be acquired under the licenses customarily provided to the public...

48 CFR 227.7202-1 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7202-1 Policy. (a) Commercial computer software or commercial computer software documentation shall be acquired under the licenses customarily provided to the public...

GPELab, a Matlab toolbox to solve Gross-Pitaevskii equations II: Dynamics and stochastic simulations

NASA Astrophysics Data System (ADS)

Antoine, Xavier; Duboscq, Romain

2015-08-01

GPELab is a free Matlab toolbox for modeling and numerically solving large classes of systems of Gross-Pitaevskii equations that arise in the physics of Bose-Einstein condensates. The aim of this second paper, which follows (Antoine and Duboscq, 2014), is to first present the various pseudospectral schemes available in GPELab for computing the deterministic and stochastic nonlinear dynamics of Gross-Pitaevskii equations (Antoine, et al., 2013). Next, the corresponding GPELab functions are explained in detail. Finally, some numerical examples are provided to show how the code works for the complex dynamics of BEC problems.

77 FR 50726 - Software Requirement Specifications for Digital Computer Software and Complex Electronics Used in...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-22

... Computer Software and Complex Electronics Used in Safety Systems of Nuclear Power Plants AGENCY: Nuclear...-1209, ``Software Requirement Specifications for Digital Computer Software and Complex Electronics used... Electronics Engineers (ANSI/IEEE) Standard 830-1998, ``IEEE Recommended Practice for Software Requirements...

Influence of Pedagogical Supervisors' Practices and Perceptions on the Use of Results-Based Management

ERIC Educational Resources Information Center

April, Daniel; Bouchamma, Yamina

2017-01-01

In the province of Québec, Canada, school principals are obligated by law to ensure pedagogical supervision. This law, the Public Education Act (Government of Québec, 2017), also advocates a contractual Results-Based Management approach (RBM). We examined how the practices and perceptions of these supervisors influence the implementation of this…

The Professional Stance of Ethics and Religious Culture Teachers in Québec

ERIC Educational Resources Information Center

Estivalèzes, Mireille

2017-01-01

In September 2008, a new Ethics and Religious Culture programme was implemented in Québec's elementary and secondary schools. One of the main pedagogical challenges of this new course has been the requirement that teachers adopt a professional stance of impartiality. Teachers must refrain from sharing their points of view, so as not to influence…

Learner Acquisition and Its Relationship with Constructivist Learner Roles in a Secondary Education Chemistry Curriculum in Québec/Canada

ERIC Educational Resources Information Center

Aydin, Abdullah

2013-01-01

This study aims to identify constructivist learner roles in acquisitions in the secondary education chemistry curriculum of the province of Québec/Canada. This research used document analysis as a qualitative research method. According to our findings; the "learner roles" in curriculum correspond with the "student roles"…

The Challenges of Mobilizing Workers on Gender Issues: Lessons from Two Studies on the Occupational Health of Teachers in Québec: Les défis de mobiliser les travailleur.ses sur la question du genre: Constats issus de deux recherches portant sur la santé au travail d'enseignant.es du Québec.

PubMed

Riel, Jessica; Major, Marie-Eve

2017-11-01

In partnership with the largest teachers' union confederation in Québec ( Centrale des syndicats du Québec), two qualitative research studies that integrate gender were conducted in the teaching community. These ergonomic studies advocated a participatory approach involving interviews and observations with high school teachers (thirty-five) and female teachers responsible for vocational training in trades with predominantly male clientele (twelve). The results revealed that gender influences work success by reducing the operational leeway available for female teachers to carry out their work and protect their health. In both studies, it was difficult to discuss these results with the teachers, especially with female teachers. Resistance, even denial, was present among high school teachers, while, in vocational training, resignation and a feeling of helplessness were observed. These reactions demonstrate that taking gender into account in prevention poses particular challenges that need to be addressed in order to promote equality between women and men in workplaces.

Vortex based information storage in Bose-Einstein condensates

NASA Astrophysics Data System (ADS)

Dutton, Zachary; Ruostekoski, Janne

2004-05-01

Recent demonstrations of coherent optical storage in atomic clouds [1,2] have opened up new possibilities for both classical and quantum information storage. In parallel, there have been advances in the generation of Laguerre-Gaussian (LG) modes with angular momentum (optical vortices)[3] and applications of these modes to quantum information architectures based on a alphabets larger than the traditional two-state systems. Here we theoretically consider the storage of such LG modes in atomic Rb-87 Bose-Einstein condensates (BECs). An LG mode writes its vortex phase pattern into a two-component BEC vortex state. The angular momentum information can then be stored in the BEC and then efficiently read back onto the optical field by switching a control field on. We study the fidelity of the writing, storage, and read-out processes. We also consider applying this method to to the transfer of more complicated states, such as two-component vortex lattices, between two spatially distinct BECs. 1. C. Liu, Z. Dutton, C.H. Behroozi, and L.V. Hau, Nature 409, 490 (2001). 2. D.F. Phillips, A. Fleischhauer, A. Mair, R.L. Walsworth, and M.D. Lukin, Phys. Rev. Lett. 86, 783 (2001). 3. A. Vaziri, Gregor Weihs, and A. Zeilinger, cond-mat/0111033.

48 CFR 227.7207 - Contractor data repositories.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Computer Software and Computer Software Documentation 227.7207 Contractor data repositories. Follow 227.7108 when it is in the Government's interests to have a data repository include computer software or to have a separate computer software repository. Contractual instruments establishing the repository...

48 CFR 227.7200 - Scope of subpart.

Code of Federal Regulations, 2013 CFR

2013-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7200 Scope of subpart. This subpart— (a) Prescribes policies and procedures for the acquisition of computer software and computer software documentation, and the...

48 CFR 227.7200 - Scope of subpart.

Code of Federal Regulations, 2014 CFR

2014-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7200 Scope of subpart. This subpart— (a) Prescribes policies and procedures for the acquisition of computer software and computer software documentation, and the...

48 CFR 227.7200 - Scope of subpart.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7200 Scope of subpart. This subpart— (a) Prescribes policies and procedures for the acquisition of computer software and computer software documentation, and the...

48 CFR 227.7207 - Contractor data repositories.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Computer Software and Computer Software Documentation 227.7207 Contractor data repositories. Follow 227.7108 when it is in the Government's interests to have a data repository include computer software or to have a separate computer software repository. Contractual instruments establishing the repository...

48 CFR 227.7207 - Contractor data repositories.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Computer Software and Computer Software Documentation 227.7207 Contractor data repositories. Follow 227.7108 when it is in the Government's interests to have a data repository include computer software or to have a separate computer software repository. Contractual instruments establishing the repository...

48 CFR 227.7200 - Scope of subpart.

Code of Federal Regulations, 2011 CFR

2011-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7200 Scope of subpart. This subpart— (a) Prescribes policies and procedures for the acquisition of computer software and computer software documentation, and the...

48 CFR 227.7207 - Contractor data repositories.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Computer Software and Computer Software Documentation 227.7207 Contractor data repositories. Follow 227.7108 when it is in the Government's interests to have a data repository include computer software or to have a separate computer software repository. Contractual instruments establishing the repository...

48 CFR 227.7200 - Scope of subpart.

Code of Federal Regulations, 2012 CFR

2012-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7200 Scope of subpart. This subpart— (a) Prescribes policies and procedures for the acquisition of computer software and computer software documentation, and the...

A hybrid approach to generating search subspaces in dynamically constrained 4-dimensional data assimilation

NASA Astrophysics Data System (ADS)

Yaremchuk, Max; Martin, Paul; Beattie, Christopher

2017-09-01

Development and maintenance of the linearized and adjoint code for advanced circulation models is a challenging issue, requiring a significant proportion of total effort in operational data assimilation (DA). The ensemble-based DA techniques provide a derivative-free alternative, which appears to be competitive with variational methods in many practical applications. This article proposes a hybrid scheme for generating the search subspaces in the adjoint-free 4-dimensional DA method (a4dVar) that does not use a predefined ensemble. The method resembles 4dVar in that the optimal solution is strongly constrained by model dynamics and search directions are supplied iteratively using information from the current and previous model trajectories generated in the process of optimization. In contrast to 4dVar, which produces a single search direction from exact gradient information, a4dVar employs an ensemble of directions to form a subspace in order to proceed. In the earlier versions of a4dVar, search subspaces were built using the leading EOFs of either the model trajectory or the projections of the model-data misfits onto the range of the background error covariance (BEC) matrix at the current iteration. In the present study, we blend both approaches and explore a hybrid scheme of ensemble generation in order to improve the performance and flexibility of the algorithm. In addition, we introduce balance constraints into the BEC structure and periodically augment the search ensemble with BEC eigenvectors to avoid repeating minimization over already explored subspaces. Performance of the proposed hybrid a4dVar (ha4dVar) method is compared with that of standard 4dVar in a realistic regional configuration assimilating real data into the Navy Coastal Ocean Model (NCOM). It is shown that the ha4dVar converges faster than a4dVar and can be potentially competitive with 4dvar both in terms of the required computational time and the forecast skill.

Multi-vortex crystal lattices in Bose-Einstein condensates with a rotating trap.

PubMed

Xie, Shuangquan; Kevrekidis, Panayotis G; Kolokolnikov, Theodore

2018-05-01

We consider vortex dynamics in the context of Bose-Einstein condensates (BECs) with a rotating trap, with or without anisotropy. Starting with the Gross-Pitaevskii (GP) partial differential equation (PDE), we derive a novel reduced system of ordinary differential equations (ODEs) that describes stable configurations of multiple co-rotating vortices (vortex crystals). This description is found to be quite accurate quantitatively especially in the case of multiple vortices. In the limit of many vortices, BECs are known to form vortex crystal structures, whereby vortices tend to arrange themselves in a hexagonal-like spatial configuration. Using our asymptotic reduction, we derive the effective vortex crystal density and its radius. We also obtain an asymptotic estimate for the maximum number of vortices as a function of rotation rate. We extend considerations to the anisotropic trap case, confirming that a pair of vortices lying on the long (short) axis is linearly stable (unstable), corroborating the ODE reduction results with full PDE simulations. We then further investigate the many-vortex limit in the case of strong anisotropic potential. In this limit, the vortices tend to align themselves along the long axis, and we compute the effective one-dimensional vortex density, as well as the maximum admissible number of vortices. Detailed numerical simulations of the GP equation are used to confirm our analytical predictions.

Counting the minutes: administrative control of work schedules and time management of secondary school teachers in Québec.

PubMed

Riel, Jessica; Messing, Karen

2011-01-01

Québec teachers have been identified as having a high level of stress and having difficulties with work-family balancing (WFB). An analysis of their work activity was done to identify task elements that could be changed. Work of 15 teachers was observed and 20 other teachers were interviewed. Ergonomic analysis, a mixed method that combines qualitative analysis with some quantitative data: 87 hours' observation; 15 interviews. Environmental parameters were recorded in 8 classrooms and in two faculty workrooms. Working postures were recorded. Teachers were subject to numerous demands in an often inadequate environment. A new management practice required teachers to spend 300 min/week outside class but in school, where their work could be monitored. The timed and scheduled tasks could not be done in the rooms provided due to overcrowding, inadequate physical environment, and lack of access to computers and telephones. Time at home decreased but work done at home did not. The physical environment of teaching impacts teaching activity. Work organization that treats a complex, results-oriented task as if it could be well represented by the number of supervised minutes spent on it can be problematic. WFB should be considered when work is re-organized.

Particle scattering by harmonically trapped Bose and Fermi gases

NASA Astrophysics Data System (ADS)

Bhattacharya, Ankita; Das, Samir; Biswas, Shyamal

2018-04-01

We have analytically explored the quantum phenomenon of particle scattering by harmonically trapped Bose and Fermi gases with the short ranged Fermi–Huang {δ }p3 interactions (Fermi 1936 Ric. Sci. 7 13; Huang and Yang 1957 Phys. Rev. 105 767) interactions among the incident particle and the scatterers. We have predicted differential scattering cross-sections and their temperature dependence in this regard. Coherent scattering even by a single boson or fermion in the finite geometry gives rise to new tool of determining energy eigenstate of the scatterer. Our predictions on the differential scattering cross-sections can be tested within the present day experimental setups, specially, for (i) 3D harmonically trapped interacting Bose–Einstein condensate (BEC), (ii) BECs in a double well, and (iii) BECs in an optical lattice.

Multicomponent Electron-Hole Superfluidity and the BCS-BEC Crossover in Double Bilayer Graphene

NASA Astrophysics Data System (ADS)

Conti, S.; Perali, A.; Peeters, F. M.; Neilson, D.

2017-12-01

Superfluidity in coupled electron-hole sheets of bilayer graphene is predicted here to be multicomponent because of the conduction and valence bands. We investigate the superfluid crossover properties as functions of the tunable carrier densities and the tunable energy band gap Eg. For small band gaps there is a significant boost in the two superfluid gaps, but the interaction-driven excitations from the valence to the conduction band can weaken the superfluidity, even blocking the system from entering the Bose-Einstein condensate (BEC) regime at low densities. At a given larger density, a band gap Eg˜80 - 120 meV can carry the system into the strong-pairing multiband BCS-BEC crossover regime, the optimal range for realization of high-Tc superfluidity.

Topical treatment of malignant and premalignant skin lesions by very low concentrations of a standard mixture (BEC) of solasodine glycosides.

PubMed

Cham, B E; Daunter, B; Evans, R A

1991-09-01

A cream formulation containing high concentrations (10%) of a standard mixture of solasodine glycosides (BEC) has been shown to be effective in the treatment of malignant and benign human skin tumours. We now report that a preparation (Curaderm) which contains very low concentrations of BEC (0.005%) is effective in the treatment of keratoses, basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin of humans. In an open study, clinical and histological observations indicated that all lesions (56 keratoses, 39 BCCs and 29 SCCs) treated with Curaderm had regressed. A placebo formulation had no effect on a smaller number of treated lesions. Curaderm had no adverse effect on the liver, kidneys or haematopoietic system.

Blow-up behavior of ground states for a nonlinear Schrödinger system with attractive and repulsive interactions

NASA Astrophysics Data System (ADS)

Guo, Yujin; Zeng, Xiaoyu; Zhou, Huan-Song

2018-01-01

We consider a nonlinear Schrödinger system arising in a two-component Bose-Einstein condensate (BEC) with attractive intraspecies interactions and repulsive interspecies interactions in R2. We get ground states of this system by solving a constrained minimization problem. For some kinds of trapping potentials, we prove that the minimization problem has a minimizer if and only if the attractive interaction strength ai (i = 1 , 2) of each component of the BEC system is strictly less than a threshold a*. Furthermore, as (a1 ,a2) ↗ (a* ,a*), the asymptotical behavior for the minimizers of the minimization problem is discussed. Our results show that each component of the BEC system concentrates at a global minimum of the associated trapping potential.

48 CFR 227.7203-11 - Contractor procedures and records.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Rights in Computer Software and Computer Software Documentation 227.7203-11 Contractor procedures and records. (a) The clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation, requires a contractor, and its subcontractors or suppliers that will...

48 CFR 212.212 - Computer software.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Computer software. 212.212... Acquisition of Commercial Items 212.212 Computer software. (1) Departments and agencies shall identify and... technology development), opportunities for the use of commercial computer software and other non...

48 CFR 227.7203-11 - Contractor procedures and records.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Rights in Computer Software and Computer Software Documentation 227.7203-11 Contractor procedures and records. (a) The clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation, requires a contractor, and its subcontractors or suppliers that will...

48 CFR 212.212 - Computer software.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Computer software. 212.212... Acquisition of Commercial Items 212.212 Computer software. (1) Departments and agencies shall identify and... technology development), opportunities for the use of commercial computer software and other non...

48 CFR 212.212 - Computer software.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Computer software. 212.212... Acquisition of Commercial Items 212.212 Computer software. (1) Departments and agencies shall identify and... technology development), opportunities for the use of commercial computer software and other non...

48 CFR 212.212 - Computer software.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Computer software. 212.212... Acquisition of Commercial Items 212.212 Computer software. (1) Departments and agencies shall identify and... technology development), opportunities for the use of commercial computer software and other non...

48 CFR 212.212 - Computer software.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Computer software. 212.212... Acquisition of Commercial Items 212.212 Computer software. (1) Departments and agencies shall identify and... technology development), opportunities for the use of commercial computer software and other non...

48 CFR 227.7203-11 - Contractor procedures and records.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Rights in Computer Software and Computer Software Documentation 227.7203-11 Contractor procedures and records. (a) The clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation, requires a contractor, and its subcontractors or suppliers that will...

48 CFR 227.7203-11 - Contractor procedures and records.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Rights in Computer Software and Computer Software Documentation 227.7203-11 Contractor procedures and records. (a) The clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation, requires a contractor, and its subcontractors or suppliers that will...

48 CFR 227.7203-11 - Contractor procedures and records.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Rights in Computer Software and Computer Software Documentation 227.7203-11 Contractor procedures and records. (a) The clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation, requires a contractor, and its subcontractors or suppliers that will...

Magnon Bose-Einstein condensation and spin superfluidity.

PubMed

Bunkov, Yuriy M; Volovik, Grigory E

2010-04-28

Bose-Einstein condensation (BEC) is a quantum phenomenon of formation of a collective quantum state in which a macroscopic number of particles occupy the lowest energy state and thus is governed by a single wavefunction. Here we highlight the BEC in a magnetic subsystem--the BEC of magnons, elementary magnetic excitations. The magnon BEC is manifested as the spontaneously emerging state of the precessing spins, in which all spins precess with the same frequency and phase even in an inhomogeneous magnetic field. The coherent spin precession was observed first in superfluid (3)He-B and this domain was called the homogeneously precessing domain (HPD). The main feature of the HPD is the induction decay signal, which ranges over many orders of magnitude longer than is prescribed by the inhomogeneity of magnetic field. This means that spins precess not with a local Larmor frequency, but coherently with a common frequency and phase. This BEC can also be created and stabilized by continuous NMR pumping. In this case the NMR frequency plays the role of a magnon chemical potential, which determines the density of the magnon condensate. The interference between two condensates has also been demonstrated. It was shown that HPD exhibits all the properties of spin superfluidity. The main property is the existence of a spin supercurrent. This spin supercurrent flows separately from the mass current. Transfer of magnetization by the spin supercurrent by a distance of more than 1 cm has been observed. Also related phenomena have been observed: the spin current Josephson effect; the phase-slip processes at the critical current; and the spin current vortex--a topological defect which is the analog of a quantized vortex in superfluids and of an Abrikosov vortex in superconductors; and so on. It is important to mention that the spin supercurrent is a magnetic phenomenon, which is not directly related to the mass superfluidity of (3)He: it is the consequence of a specific antiferromagnetic ordering in superfluid (3)He. Several different states of coherent precession have been observed in (3)He-B: the homogeneously precessing domain (HPD); a persistent signal formed by Q-balls at very low temperatures; coherent precession with fractional magnetization; and two new modes of coherent precession in compressed aerogel. In compressed aerogel the coherent precession has been also found in (3)He-A. We demonstrate that the coherent precession of magnetization is a true BEC of magnons, with the magnon interaction term in the Gross-Pitaevskii equation being provided by spin-orbit coupling which is different for different states of the magnon BEC.

48 CFR 212.7003 - Technical data and computer software.

Code of Federal Regulations, 2011 CFR

2011-10-01

... computer software. 212.7003 Section 212.7003 Federal Acquisition Regulations System DEFENSE ACQUISITION... data and computer software. For purposes of establishing delivery requirements and license rights for technical data under 227.7102 and for computer software under 227.7202, there shall be a rebuttable...

48 CFR 212.7003 - Technical data and computer software.

Code of Federal Regulations, 2013 CFR

2013-10-01

... computer software. 212.7003 Section 212.7003 Federal Acquisition Regulations System DEFENSE ACQUISITION... data and computer software. For purposes of establishing delivery requirements and license rights for technical data under 227.7102 and for computer software under 227.7202, there shall be a rebuttable...

48 CFR 212.7003 - Technical data and computer software.

Code of Federal Regulations, 2012 CFR

2012-10-01

... computer software. 212.7003 Section 212.7003 Federal Acquisition Regulations System DEFENSE ACQUISITION... data and computer software. For purposes of establishing delivery requirements and license rights for technical data under 227.7102 and for computer software under 227.7202, there shall be a rebuttable...

48 CFR 212.7003 - Technical data and computer software.

Code of Federal Regulations, 2014 CFR

2014-10-01

... computer software. 212.7003 Section 212.7003 Federal Acquisition Regulations System DEFENSE ACQUISITION... data and computer software. For purposes of establishing delivery requirements and license rights for technical data under 227.7102 and for computer software under 227.7202, there shall be a rebuttable...

48 CFR 212.7003 - Technical data and computer software.

Code of Federal Regulations, 2010 CFR

2010-10-01

... computer software. 212.7003 Section 212.7003 Federal Acquisition Regulations System DEFENSE ACQUISITION... data and computer software. For purposes of establishing delivery requirements and license rights for technical data under 227.7102 and for computer software under 227.7202, there shall be a rebuttable...

77 FR 50722 - Software Unit Testing for Digital Computer Software Used in Safety Systems of Nuclear Power Plants

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-22

... NUCLEAR REGULATORY COMMISSION [NRC-2012-0195] Software Unit Testing for Digital Computer Software...) is issuing for public comment draft regulatory guide (DG), DG-1208, ``Software Unit Testing for Digital Computer Software used in Safety Systems of Nuclear Power Plants.'' The DG-1208 is proposed...

78 FR 47011 - Software Unit Testing for Digital Computer Software Used in Safety Systems of Nuclear Power Plants

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-02

... NUCLEAR REGULATORY COMMISSION [NRC-2012-0195] Software Unit Testing for Digital Computer Software... revised regulatory guide (RG), revision 1 of RG 1.171, ``Software Unit Testing for Digital Computer Software Used in Safety Systems of Nuclear Power Plants.'' This RG endorses American National Standards...

48 CFR 227.7203-4 - License rights.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Software and Computer Software Documentation 227.7203-4 License rights. (a) Grant of license. The Government obtains rights in computer software or computer software documentation, including a copyright license, under an irrevocable license granted or obtained by the contractor which developed the software...

48 CFR 227.7203-4 - License rights.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Software and Computer Software Documentation 227.7203-4 License rights. (a) Grant of license. The Government obtains rights in computer software or computer software documentation, including a copyright license, under an irrevocable license granted or obtained by the contractor which developed the software...

48 CFR 227.7203-4 - License rights.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Software and Computer Software Documentation 227.7203-4 License rights. (a) Grant of license. The Government obtains rights in computer software or computer software documentation, including a copyright license, under an irrevocable license granted or obtained by the contractor which developed the software...

48 CFR 227.7203-4 - License rights.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Software and Computer Software Documentation 227.7203-4 License rights. (a) Grant of license. The Government obtains rights in computer software or computer software documentation, including a copyright license, under an irrevocable license granted or obtained by the contractor which developed the software...

48 CFR 227.7203-4 - License rights.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Software and Computer Software Documentation 227.7203-4 License rights. (a) Grant of license. The Government obtains rights in computer software or computer software documentation, including a copyright license, under an irrevocable license granted or obtained by the contractor which developed the software...

Making "Good" or "Critical" Citizens: From Social Justice to Financial Literacy in the Québec Education Program

ERIC Educational Resources Information Center

Lefrançois, David; Ethier, Marc-André; Cambron-Prémont, Amélie

2017-01-01

Purpose: The Québec Ministry of Education has introduced--as of September 2017--a new mandatory course focusing on financial literacy and addressing such issues as credit scores, loans, taxes and budgets. This announcement has created intense educational debate on the "raison d'être" and content of the course. This article will summarise…

48 CFR 227.7203-12 - Government right to establish conformity of markings.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-12... identified in the clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation. All other markings are nonconforming markings. An authorized marking that...

48 CFR 227.7203-12 - Government right to establish conformity of markings.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-12... identified in the clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation. All other markings are nonconforming markings. An authorized marking that...

48 CFR 227.7203-12 - Government right to establish conformity of markings.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-12... identified in the clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation. All other markings are nonconforming markings. An authorized marking that...

48 CFR 227.7203-12 - Government right to establish conformity of markings.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-12... identified in the clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation. All other markings are nonconforming markings. An authorized marking that...

48 CFR 227.7203-12 - Government right to establish conformity of markings.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7203-12... identified in the clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation. All other markings are nonconforming markings. An authorized marking that...

Exploring the Process of Adult Computer Software Training Using Andragogy, Situated Cognition, and a Minimalist Approach

ERIC Educational Resources Information Center

Hurt, Andrew C.

2007-01-01

With technology advances, computer software becomes increasingly difficult to learn. Adults often rely on software training to keep abreast of these changes. Instructor-led software training is frequently used to teach adults new software skills; however there is limited research regarding the best practices in adult computer software training.…

48 CFR 252.227-7032 - Rights in technical data and computer software (foreign).

Code of Federal Regulations, 2013 CFR

2013-10-01

... and computer software (foreign). 252.227-7032 Section 252.227-7032 Federal Acquisition Regulations... computer software (foreign). As prescribed in 227.7103-17, use the following clause: Rights in Technical Data and Computer Software (Foreign) (JUN 1975) The United States Government may duplicate, use, and...

48 CFR 252.227-7032 - Rights in technical data and computer software (foreign).

Code of Federal Regulations, 2014 CFR

2014-10-01

... and computer software (foreign). 252.227-7032 Section 252.227-7032 Federal Acquisition Regulations... computer software (foreign). As prescribed in 227.7103-17, use the following clause: Rights in Technical Data and Computer Software (Foreign) (JUN 1975) The United States Government may duplicate, use, and...

75 FR 6185 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Rights in...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-08

...; Defense Federal Acquisition Regulation Supplement; Rights in Technical Data and Computer Software (OMB... 227.72, Rights in Computer Software and Computer Software Documentation, and related provisions and... rights in technical data and computer software. DoD needs this information to implement 10 U.S.C. 2320...

14 CFR 415.123 - Computing systems and software.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Computing systems and software. 415.123... Launch Vehicle From a Non-Federal Launch Site § 415.123 Computing systems and software. (a) An applicant's safety review document must describe all computing systems and software that perform a safety...

14 CFR 415.123 - Computing systems and software.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Computing systems and software. 415.123... Launch Vehicle From a Non-Federal Launch Site § 415.123 Computing systems and software. (a) An applicant's safety review document must describe all computing systems and software that perform a safety...

48 CFR 252.227-7032 - Rights in technical data and computer software (foreign).

Code of Federal Regulations, 2011 CFR

2011-10-01

... and computer software (foreign). 252.227-7032 Section 252.227-7032 Federal Acquisition Regulations... computer software (foreign). As prescribed in 227.7103-17, use the following clause: Rights in Technical Data and Computer Software (Foreign) (JUN 1975) The United States Government may duplicate, use, and...

48 CFR 252.227-7032 - Rights in technical data and computer software (foreign).

Code of Federal Regulations, 2012 CFR

2012-10-01

... and computer software (foreign). 252.227-7032 Section 252.227-7032 Federal Acquisition Regulations... computer software (foreign). As prescribed in 227.7103-17, use the following clause: Rights in Technical Data and Computer Software (Foreign) (JUN 1975) The United States Government may duplicate, use, and...

48 CFR 252.227-7032 - Rights in technical data and computer software (foreign).

Code of Federal Regulations, 2010 CFR

2010-10-01

... and computer software (foreign). 252.227-7032 Section 252.227-7032 Federal Acquisition Regulations... computer software (foreign). As prescribed in 227.7103-17, use the following clause: Rights in Technical Data and Computer Software (Foreign) (JUN 1975) The United States Government may duplicate, use, and...

78 FR 30898 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement; Rights in...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-23

... Data and Computer Software AGENCY: Defense Acquisition Regulations System; Department of Defense (DoD... in Technical Data, and Subpart 227.72, Rights in Computer Software and Computer Software... are associated with rights in technical data and computer software. DoD needs this information to...

14 CFR 415.123 - Computing systems and software.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Computing systems and software. 415.123... Launch Vehicle From a Non-Federal Launch Site § 415.123 Computing systems and software. (a) An applicant's safety review document must describe all computing systems and software that perform a safety...

14 CFR 415.123 - Computing systems and software.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Computing systems and software. 415.123... Launch Vehicle From a Non-Federal Launch Site § 415.123 Computing systems and software. (a) An applicant's safety review document must describe all computing systems and software that perform a safety...

14 CFR 415.123 - Computing systems and software.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Computing systems and software. 415.123... Launch Vehicle From a Non-Federal Launch Site § 415.123 Computing systems and software. (a) An applicant's safety review document must describe all computing systems and software that perform a safety...

High expression of insulin receptor on tumour-associated blood vessels in invasive bladder cancer predicts poor overall and progression-free survival.

PubMed

Roudnicky, Filip; Dieterich, Lothar C; Poyet, Cedric; Buser, Lorenz; Wild, Peter; Tang, Dave; Camenzind, Peter; Ho, Chien Hsien; Otto, Vivianne I; Detmar, Michael

2017-06-01

Bladder cancer is a frequently recurring disease with a very poor prognosis once progressed to invasive stages, and tumour-associated blood vessels play a crucial role in this process. In order to identify novel biomarkers associated with progression, we isolated blood vascular endothelial cells (BECs) from human invasive bladder cancers and matched normal bladder tissue, and found that tumour-associated BECs greatly up-regulated the expression of insulin receptor (INSR). High expression of INSR on BECs of invasive bladder cancers was significantly associated with shorter progression-free and overall survival. Furthermore, increased expression of the INSR ligand IGF-2 in invasive bladder cancers was associated with reduced overall survival. INSR may therefore represent a novel biomarker to predict cancer progression. Mechanistically, we observed pronounced hypoxia in human bladder cancer tissue, and found a positive correlation between the expression of the hypoxia marker gene GLUT1 and vascular INSR expression, indicating that hypoxia drives INSR expression in tumour-associated blood vessels. In line with this, exposure of cultured BECs and human bladder cancer cell lines to hypoxia led to increased expression of INSR and IGF-2, respectively, and IGF-2 increased BEC migration through the activation of INSR in vitro. Taken together, we identified vascular INSR expression as a potential biomarker for progression in bladder cancer. Furthermore, our data suggest that IGF-2/INSR mediated paracrine crosstalk between bladder cancer cells and endothelial cells is functionally involved in tumour angiogenesis and may thus represent a new therapeutic target. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Hybrid Optical-Magnetic Traps for Studies of 2D Quantum Turbulence in Bose-Einstein Condensates

NASA Astrophysics Data System (ADS)

Myers, Jessica Ann

Turbulence appears in most natural and man-made flows. However, the analysis of turbulence is particularly difficult. Links between microscopic fluid dynamics and statistical signatures of turbulence appear unobtainable from the postulates of fluid dynamics making turbulence one of the most important unsolved theoretical problems in physics. Two-dimensional quantum turbulence (2DQT), an emerging field of study, involves turbulence in two-dimensional (2D) flows in superfluids, such as Bose-Einstein condensates (BECs). In 2D superfluids, a turbulent state can be characterized by a disordered distribution of numerous vortex cores. The question of how to effectively and efficiently generate turbulent states in superfluids is a fundamental question in the field of quantum turbulence. Therefore, experimental studies of vortex nucleation and the onset of turbulence in a superfluid are important for achieving a deeper understanding of the overall problem of turbulence. My PhD dissertation involves the study of vortex nucleation and the onset of turbulence in quasi-2D BECs. First, I discuss experimental apparatus advancements that now enable BECs to be created in a hybrid optical-magnetic trap, an atom trapping configuration conducive to 2DQT experiments. Next, I discuss the design and construction of a quantum vortex microscope and initial vortex detection tests. Finally, I present the first experiments aimed at studying 2DQT carried out in the updated apparatus. Thermal counterflow in superfluid helium, in which the normal and superfluid components flow in opposite directions, is known to create turbulence in the superfluid. However, this phenomenon has not been simulated or studied in dilute-gas BECs as a possible vortex nucleation method. In this dissertation, I present preliminary data from the first experiments aimed at understanding thermal counterflow turbulence in dilute-gas BECs.

Pharmacologically relevant intake during chronic, free-choice drinking rhythms in selectively bred high alcohol-preferring mice.

PubMed

Matson, Liana M; Grahame, Nicholas J

2013-11-01

Multiple lines of high alcohol-preferring (HAP) mice were selectively bred for their intake of 10% ethanol (v/v) during 24-hour daily access over a 4-week period, with the highest drinking lines exhibiting intakes in excess of 20 g/kg/day. We observed circadian drinking patterns and resulting blood ethanol concentrations (BECs) in the HAP lines. We also compared the drinking rhythms and corresponding BECs of the highest drinking HAP lines to those of the C57BL/6J (B6) inbred strain. Adult male and female crossed HAP (cHAP), HAP replicate lines 1, 2, 3 and B6 mice had free-choice access to 10% ethanol and water for 3 weeks prior to bi-hourly assessments of intake throughout the dark portion of the light-dark cycle. All HAP lines reached and maintained a rate of alcohol intake above the rate at which HAP1 mice metabolize alcohol, and BECs were consistent with this finding. Further, cHAP and HAP1 mice maintained an excessive level of intake throughout the dark portion of the cycle, accumulating mean BEC levels of 261.5 ± 18.09 and 217.9 ± 25.02 mg/dl, respectively. B6 mice drank comparatively modestly, and did not accumulate high BEC levels (53.63 + 8.15 mg/dl). Free-choice drinking demonstrated by the HAP1 and cHAP lines may provide a unique opportunity for modeling the excessive intake that often occurs in alcohol-dependent individuals, and allow for exploration of predisposing factors for excessive consumption, as well as the development of physiological, behavioral and toxicological outcomes following alcohol exposure. © 2011 The Authors, Addiction Biology © 2011 Society for the Study of Addiction.

Temperature Dependence of the Upper Critical Field in Disordered Hubbard Model with Attraction

NASA Astrophysics Data System (ADS)

Kuchinskii, E. Z.; Kuleeva, N. A.; Sadovskii, M. V.

2017-12-01

We study disorder effects upon the temperature behavior of the upper critical magnetic field in an attractive Hubbard model within the generalized DMFT+Σ approach. We consider the wide range of attraction potentials U—from the weak coupling limit, where superconductivity is described by BCS model, up to the strong coupling limit, where superconducting transition is related to Bose-Einstein condensation (BEC) of compact Cooper pairs, formed at temperatures significantly higher than superconducting transition temperature, as well as the wide range of disorder—from weak to strong, when the system is in the vicinity of Anderson transition. The growth of coupling strength leads to the rapid growth of H c2( T), especially at low temperatures. In BEC limit and in the region of BCS-BEC crossover H c2( T), dependence becomes practically linear. Disordering also leads to the general growth of H c2( T). In BCS limit of weak coupling increasing disorder lead both to the growth of the slope of the upper critical field in the vicinity of the transition point and to the increase of H c2( T) in the low temperature region. In the limit of strong disorder in the vicinity of the Anderson transition localization corrections lead to the additional growth of H c2( T) at low temperatures, so that the H c2( T) dependence becomes concave. In BCS-BEC crossover region and in BEC limit disorder only slightly influences the slope of the upper critical field close to T c . However, in the low temperature region H c2 ( T may significantly grow with disorder in the vicinity of the Anderson transition, where localization corrections notably increase H c2 ( T = 0) also making H c2( T) dependence concave.

Functional magnetic resonance imaging phase synchronization as a measure of dynamic functional connectivity.

PubMed

Glerean, Enrico; Salmi, Juha; Lahnakoski, Juha M; Jääskeläinen, Iiro P; Sams, Mikko

2012-01-01

Functional brain activity and connectivity have been studied by calculating intersubject and seed-based correlations of hemodynamic data acquired with functional magnetic resonance imaging (fMRI). To inspect temporal dynamics, these correlation measures have been calculated over sliding time windows with necessary restrictions on the length of the temporal window that compromises the temporal resolution. Here, we show that it is possible to increase temporal resolution by using instantaneous phase synchronization (PS) as a measure of dynamic (time-varying) functional connectivity. We applied PS on an fMRI dataset obtained while 12 healthy volunteers watched a feature film. Narrow frequency band (0.04-0.07 Hz) was used in the PS analysis to avoid artifactual results. We defined three metrics for computing time-varying functional connectivity and time-varying intersubject reliability based on estimation of instantaneous PS across the subjects: (1) seed-based PS, (2) intersubject PS, and (3) intersubject seed-based PS. Our findings show that these PS-based metrics yield results consistent with both seed-based correlation and intersubject correlation methods when inspected over the whole time series, but provide an important advantage of maximal single-TR temporal resolution. These metrics can be applied both in studies with complex naturalistic stimuli (e.g., watching a movie or listening to music in the MRI scanner) and more controlled (e.g., event-related or blocked design) paradigms. A MATLAB toolbox FUNPSY ( http://becs.aalto.fi/bml/software.html ) is openly available for using these metrics in fMRI data analysis.

Culling from the herd's perspective-Exploring herd-level management factors and culling rates in Québec dairy herds.

PubMed

Haine, Denis; Delgado, Hector; Cue, Roger; Sewalem, Asheber; Wade, Kevin; Lacroix, René; Lefebvre, Daniel; Arsenault, Julie; Bouchard, Émile; Dubuc, Jocelyn

2017-11-01

The relationship between cows' health, reproductive performance or disorders and their longevity is well demonstrated in the literature. However these associations at the cow level might not hold true at the herd level, and herd-level variables can modify cow-level outcomes independently of the cows' characteristics. The interaction between cow-level and herd-level variables is a relevant issue for understanding the culling of dairy cows. However it requires the appropriate group-level variables to assess any contextual effect. Based on 10 years of health and production data, the objectives of this paper are:(a) to quantify the culling rates of dairy herds in Québec; (b) to determine the profiles of the herds based on herd-level factors, such as demographics, reproduction, production and health indicators, and whether these profiles can be related to herd culling rates for use as potential contextual variables in multilevel modelling of culling risk. A retrospective longitudinal study was conducted on data from dairy herds in Québec, Canada, by extracting health information events from the dairy herd health management software used by most Québec producers and their veterinarians. Data were extracted for all lactations taking place between January 1st, 2001 and December 31st, 2010. A total of 432,733 lactations from 156,409 cows out of 763 herds were available for analysis. Thirty cow-level variables were aggregated for each herd and years of follow-up, and their relationship was investigated by Multiple Factor Analysis (MFA). The overall annual culling rate was 32%, with a 95% confidence interval (CI) of [31.6%,32.5%]. The dairy sale rate by 60 days in milk (DIM) was 3.2% [2.8%,3.6%]. The annual culling rate within 60 DIM was 8.2% [7.9%,8.4%]. The explained variance for each axis from the MFA was very low: 14.8% for the first axis and 13.1% for the second. From the MFA results, we conclude there is no relationship between the groups of herd-level indicators, demonstrating the heterogeneity among herds for their demographics, reproduction and production performance, and health status. However, based on Principal Component Analysis (PCA), the profiles of herds could be determined according to specific, single, herd-level indicators independently. The relationships between culling rates and specific herd-level variables within factors were limited to livestock sales, proportion of first lactation cows, herd size, proportion of calvings occurring in the fall, longer calving intervals and reduced 21-day pregnancy rates, increased days to first service, average age at first calving, and reduced milk fever incidence. The indicators found could be considered as contextual variables in multilevel model-building strategies to investigate cow culling risk. Copyright © 2017 Elsevier B.V. All rights reserved.

An efficient nonlinear Feshbach engine

NASA Astrophysics Data System (ADS)

Li, Jing; Fogarty, Thomás; Campbell, Steve; Chen, Xi; Busch, Thomas

2018-01-01

We investigate a thermodynamic cycle using a Bose-Einstein condensate (BEC) with nonlinear interactions as the working medium. Exploiting Feshbach resonances to change the interaction strength of the BEC allows us to produce work by expanding and compressing the gas. To ensure a large power output from this engine these strokes must be performed on a short timescale, however such non-adiabatic strokes can create irreversible work which degrades the engine’s efficiency. To combat this, we design a shortcut to adiabaticity which can achieve an adiabatic-like evolution within a finite time, therefore significantly reducing the out-of-equilibrium excitations in the BEC. We investigate the effect of the shortcut to adiabaticity on the efficiency and power output of the engine and show that the tunable nonlinearity strength, modulated by Feshbach resonances, serves as a useful tool to enhance the system’s performance.

Selective distillation phenomenon in two-species Bose-Einstein condensates in open boundary optical lattices.

PubMed

Bai, Xiao-Dong; Zhang, Mei; Xiong, Jun; Yang, Guo-Jian; Deng, Fu-Guo

2015-11-24

We investigate the formation of discrete breathers (DBs) and the dynamics of the mixture of two-species Bose-Einstein condensates (BECs) in open boundary optical lattices using the discrete nonlinear Schrödinger equations. The results show that the coupling of intra- and interspecies interaction can lead to the existence of pure single-species DBs and symbiotic DBs (i.e., two-species DBs). Furthermore, we find that there is a selective distillation phenomenon in the dynamics of the mixture of two-species BECs. One can selectively distil one species from the mixture of two-species BECs and can even control dominant species fraction by adjusting the intra- and interspecies interaction in optical lattices. Our selective distillation mechanism may find potential application in quantum information storage and quantum information processing based on multi-species atoms.

Selective distillation phenomenon in two-species Bose-Einstein condensates in open boundary optical lattices

PubMed Central

Bai, Xiao-Dong; Zhang, Mei; Xiong, Jun; Yang, Guo-Jian; Deng, Fu-Guo

2015-01-01

We investigate the formation of discrete breathers (DBs) and the dynamics of the mixture of two-species Bose-Einstein condensates (BECs) in open boundary optical lattices using the discrete nonlinear Schrödinger equations. The results show that the coupling of intra- and interspecies interaction can lead to the existence of pure single-species DBs and symbiotic DBs (i.e., two-species DBs). Furthermore, we find that there is a selective distillation phenomenon in the dynamics of the mixture of two-species BECs. One can selectively distil one species from the mixture of two-species BECs and can even control dominant species fraction by adjusting the intra- and interspecies interaction in optical lattices. Our selective distillation mechanism may find potential application in quantum information storage and quantum information processing based on multi-species atoms. PMID:26597592

Bose-Einstein Condensation of Long-Lifetime Polaritons in Thermal Equilibrium.

PubMed

Sun, Yongbao; Wen, Patrick; Yoon, Yoseob; Liu, Gangqiang; Steger, Mark; Pfeiffer, Loren N; West, Ken; Snoke, David W; Nelson, Keith A

2017-01-06

The experimental realization of Bose-Einstein condensation (BEC) with atoms and quasiparticles has triggered wide exploration of macroscopic quantum effects. Microcavity polaritons are of particular interest because quantum phenomena such as BEC and superfluidity can be observed at elevated temperatures. However, polariton lifetimes are typically too short to permit thermal equilibration. This has led to debate about whether polariton condensation is intrinsically a nonequilibrium effect. Here we report the first unambiguous observation of BEC of optically trapped polaritons in thermal equilibrium in a high-Q microcavity, evidenced by equilibrium Bose-Einstein distributions over broad ranges of polariton densities and bath temperatures. With thermal equilibrium established, we verify that polariton condensation is a phase transition with a well-defined density-temperature phase diagram. The measured phase boundary agrees well with the predictions of basic quantum gas theory.

Feedback control of an interacting Bose-Einstein condensate using phase-contrast imaging

NASA Astrophysics Data System (ADS)

Szigeti, S. S.; Hush, M. R.; Carvalho, A. R. R.; Hope, J. J.

2010-10-01

The linewidth of an atom laser is limited by density fluctuations in the Bose-Einstein condensate (BEC) from which the atom laser beam is outcoupled. In this paper we show that a stable spatial mode for an interacting BEC can be generated using a realistic control scheme that includes the effects of the measurement backaction. This model extends the feedback theory, based on a phase-contrast imaging setup, presented by Szigeti, Hush, Carvalho, and Hope [Phys. Rev. APLRAAN1050-294710.1103/PhysRevA.80.013614 80, 013614 (2009)]. In particular, it is applicable to a BEC with large interatomic interactions and solves the problem of inadequacy of the mean-field (coherent state) approximation by utilizing a fixed number state approximation. Our numerical analysis shows the control to be more effective for a condensate with a large nonlinearity.

Feedback control of an interacting Bose-Einstein condensate using phase-contrast imaging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Szigeti, S. S.; Hush, M. R.; Carvalho, A. R. R.

2010-10-15

The linewidth of an atom laser is limited by density fluctuations in the Bose-Einstein condensate (BEC) from which the atom laser beam is outcoupled. In this paper we show that a stable spatial mode for an interacting BEC can be generated using a realistic control scheme that includes the effects of the measurement backaction. This model extends the feedback theory, based on a phase-contrast imaging setup, presented by Szigeti, Hush, Carvalho, and Hope [Phys. Rev. A 80, 013614 (2009)]. In particular, it is applicable to a BEC with large interatomic interactions and solves the problem of inadequacy of the mean-fieldmore » (coherent state) approximation by utilizing a fixed number state approximation. Our numerical analysis shows the control to be more effective for a condensate with a large nonlinearity.« less

Superradiance and dynamical instability in an illuminated BEC

NASA Astrophysics Data System (ADS)

Lunden, William; Amato-Grill, Jesse; Dimitrova, Ivana; Jepsen, Niklas; Ketterle, Wolfgang

2017-04-01

An elongated, trapped Bose-Einstein condensate illuminated by an off-resonant laser beam has been used as a platform to observe superradiant Rayleigh scattering for almost two decades. We now consider the case of an elongated BEC illuminated by a pair of non-interfering, off-resonant lasers, and explore the dynamics of the coupled light-matter system in the short-time regime (i.e., times on the order of the inverse of the single-photon recoil frequency). In particular, we look for signatures of a proposed dynamical instability in the coupled system which spontaneously breaks the translational symmetry of both the BEC density and the total light field's intensity profile along the long axis of the trap. We also explore the relative roles of the spontaneous light force and the dipole force in both superradiance and this dynamical instability.

Non-destructive imaging of spinor Bose-Einstein condensates

NASA Astrophysics Data System (ADS)

Samson, E.; Vinit, Anshuman; Raman, Chandra

2013-05-01

We present a non-destructive differential imaging technique that enables the observation of the spatial distribution of the magnetization in a spinor Bose-Einstein condensate (BEC) through a Faraday rotation protocol. In our procedure, we utilize a linearly polarized, far-detuned laser beam as our imaging probe, and upon interaction with the condensate, the beam's polarization direction undergoes Faraday rotation. A differential measurement of the orthogonal polarization components of the rotated beam provides a spatial map of the net magnetization density within the BEC. The non-destructive aspect of this method allows for continuous imaging of the condensate. This imaging technique will prove useful in experimental BEC studies, such as spatially resolved magnetometry using ultracold atoms, and non-destructive imaging of non-equilibrium behavior of antiferromagnetic spinor condensates. This work was supported by the DARPA QuASAR program through a grant from ARO.

Remote entanglement between a single atom and a Bose-Einstein condensate.

PubMed

Lettner, M; Mücke, M; Riedl, S; Vo, C; Hahn, C; Baur, S; Bochmann, J; Ritter, S; Dürr, S; Rempe, G

2011-05-27

Entanglement between stationary systems at remote locations is a key resource for quantum networks. We report on the experimental generation of remote entanglement between a single atom inside an optical cavity and a Bose-Einstein condensate (BEC). To produce this, a single photon is created in the atom-cavity system, thereby generating atom-photon entanglement. The photon is transported to the BEC and converted into a collective excitation in the BEC, thus establishing matter-matter entanglement. After a variable delay, this entanglement is converted into photon-photon entanglement. The matter-matter entanglement lifetime of 100 μs exceeds the photon duration by 2 orders of magnitude. The total fidelity of all concatenated operations is 95%. This hybrid system opens up promising perspectives in the field of quantum information. © 2011 American Physical Society

Zika virus crosses an in vitro human blood brain barrier model.

PubMed

Alimonti, Judie B; Ribecco-Lutkiewicz, Maria; Sodja, Caroline; Jezierski, Anna; Stanimirovic, Danica B; Liu, Qing; Haqqani, Arsalan S; Conlan, Wayne; Bani-Yaghoub, Mahmud

2018-05-15

Zika virus (ZIKV) is a flavivirus that is highly neurotropic causing congenital abnormalities and neurological damage to the central nervous systems (CNS). In this study, we used a human induced pluripotent stem cell (iPSC)-derived blood brain barrier (BBB) model to demonstrate that ZIKV can infect brain endothelial cells (i-BECs) without compromising the BBB barrier integrity or permeability. Although no disruption to the BBB was observed post-infection, ZIKV particles were released on the abluminal side of the BBB model and infected underlying iPSC-derived neural progenitor cells (i-NPs). AXL, a putative ZIKV cellular entry receptor, was also highly expressed in ZIKV-susceptible i-BEC and i-NPs. This iPSC-derived BBB model can help elucidate the mechanism by which ZIKV can infect BECs, cross the BBB and gain access to the CNS.

The Eastern Québec Telepathology Network: a three-year experience of clinical diagnostic services

PubMed Central

2014-01-01

Background The Eastern Quebec Telepathology Network (called Réseau de Télépathologie de l'Est du Québec in French) was created to provide uniform diagnostic telepathology services in a huge territory with low population density. We report our first 3-year experience. Methods The network was funded equally by the Québec ministry of Health and Canada Health Infoway, a federal telehealth funding agency. The coverage includes intraoperative consultations (IOC), expert opinions, urgent analyses and supervision of macroscopic description. The deployment of the equipment and software started in 2010 and clinical activities began in January 2011. This network comprises 24 hospitals providing oncologic surgery, of which 7 have no pathology laboratory and 4 have a pathology laboratory but no pathologist. The real-time gross evaluation during IOC was performed using a macroscopy station and the sample selection was performed distantly by a technician, a pathology assistant or the surgeon under on-site pathologist supervision. Slides were scanned into whole-slide images (WSI). Results As per March 2014, 7,440 slides had been scanned for primary/urgent diagnosis; 1,329 for IOC cases and 2,308 for expert opinions. A 98% concordance rate was found for IOC compared to paraffin material and the average turnaround time was 20 minutes. Expert opinion reports were signed out within 24 hours in 68% of cases and within 72 hours in 85%. A recent multi-method evaluation study of the Network demonstrated that, thanks to telepathology: 1. interruption of IOC service was prevented in hospitals with no pathologist on site; 2. two-stage surgeries and patients transfers were prevented according to surgeons and pathologists; 3. retention and recruitment of surgeons in remote hospitals were facilitated; and 4. professional isolation among pathologists working alone was reduced. This study also demonstrated that wider adoption of telepathology would require technological improvement and that the sustainability of the network requires better coordination and the development of a supra-regional pathology organisation. Conclusion The Eastern Quebec Telepathology Network allowed the maintenance of rapid and high quality pathology services in more than 20 sites disseminated on a huge territory. A second phase is underway to expand telepathology to other regions across the province. PMID:25564940

37 CFR 201.26 - Recordation of documents pertaining to computer shareware and donation of public domain computer...

Code of Federal Regulations, 2011 CFR

2011-07-01

... pertaining to computer shareware and donation of public domain computer software. 201.26 Section 201.26... public domain computer software. (a) General. This section prescribes the procedures for submission of legal documents pertaining to computer shareware and the deposit of public domain computer software...

37 CFR 201.26 - Recordation of documents pertaining to computer shareware and donation of public domain computer...

Code of Federal Regulations, 2010 CFR

2010-07-01

... pertaining to computer shareware and donation of public domain computer software. 201.26 Section 201.26... public domain computer software. (a) General. This section prescribes the procedures for submission of legal documents pertaining to computer shareware and the deposit of public domain computer software...

37 CFR 201.26 - Recordation of documents pertaining to computer shareware and donation of public domain computer...

Code of Federal Regulations, 2013 CFR

2013-07-01

... pertaining to computer shareware and donation of public domain computer software. 201.26 Section 201.26... public domain computer software. (a) General. This section prescribes the procedures for submission of legal documents pertaining to computer shareware and the deposit of public domain computer software...

37 CFR 201.26 - Recordation of documents pertaining to computer shareware and donation of public domain computer...

Code of Federal Regulations, 2012 CFR

2012-07-01

... pertaining to computer shareware and donation of public domain computer software. 201.26 Section 201.26... public domain computer software. (a) General. This section prescribes the procedures for submission of legal documents pertaining to computer shareware and the deposit of public domain computer software...

78 FR 47804 - Verification, Validation, Reviews, and Audits for Digital Computer Software Used in Safety...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-06

..., ``Configuration Management Plans for Digital Computer Software used in Safety Systems of Nuclear Power Plants... Digital Computer Software Used in Safety Systems of Nuclear Power Plants AGENCY: Nuclear Regulatory..., Reviews, and Audits for Digital Computer Software Used in Safety Systems of Nuclear Power Plants.'' This...

48 CFR 27.404-2 - Limited rights data and restricted computer software.

Code of Federal Regulations, 2011 CFR

2011-10-01

... restricted computer software. 27.404-2 Section 27.404-2 Federal Acquisition Regulations System FEDERAL... Copyrights 27.404-2 Limited rights data and restricted computer software. (a) General. The basic clause at 52... restricted computer software by withholding the data from the Government and instead delivering form, fit...

48 CFR 252.227-7026 - Deferred delivery of technical data or computer software.

Code of Federal Regulations, 2010 CFR

2010-10-01

... technical data or computer software. 252.227-7026 Section 252.227-7026 Federal Acquisition Regulations... data or computer software. As prescribed at 227.7103-8(a), use the following clause: Deferred Delivery of Technical Data or Computer Software (APR 1988) The Government shall have the right to require, at...

48 CFR 27.404-2 - Limited rights data and restricted computer software.

Code of Federal Regulations, 2014 CFR

2014-10-01

... restricted computer software. 27.404-2 Section 27.404-2 Federal Acquisition Regulations System FEDERAL... Copyrights 27.404-2 Limited rights data and restricted computer software. (a) General. The basic clause at 52... restricted computer software by withholding the data from the Government and instead delivering form, fit...

48 CFR 52.227-15 - Representation of Limited Rights Data and Restricted Computer Software.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Rights Data and Restricted Computer Software. 52.227-15 Section 52.227-15 Federal Acquisition Regulations... Computer Software. As prescribed in 27.409(c), insert the following provision: Representation of Limited Rights Data and Restricted Computer Software (DEC 2007) (a) This solicitation sets forth the Government's...

48 CFR 252.227-7025 - Limitations on the use or disclosure of government-furnished information marked with restrictive...

Code of Federal Regulations, 2011 CFR

2011-10-01

... contracts in which the Government will furnish the Contractor with computer software or computer software... rights” are defined in the clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation. (3) For Small Business Innovation Research program contracts, the...

48 CFR 27.404-2 - Limited rights data and restricted computer software.

Code of Federal Regulations, 2012 CFR

2012-10-01

... restricted computer software. 27.404-2 Section 27.404-2 Federal Acquisition Regulations System FEDERAL... Copyrights 27.404-2 Limited rights data and restricted computer software. (a) General. The basic clause at 52... restricted computer software by withholding the data from the Government and instead delivering form, fit...

48 CFR 52.227-15 - Representation of Limited Rights Data and Restricted Computer Software.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Rights Data and Restricted Computer Software. 52.227-15 Section 52.227-15 Federal Acquisition Regulations... Computer Software. As prescribed in 27.409(c), insert the following provision: Representation of Limited Rights Data and Restricted Computer Software (DEC 2007) (a) This solicitation sets forth the Government's...

48 CFR 252.227-7019 - Validation of asserted restrictions-Computer software.

Code of Federal Regulations, 2010 CFR

2010-10-01

... restrictions-Computer software. 252.227-7019 Section 252.227-7019 Federal Acquisition Regulations System...—Computer software. As prescribed in 227.7104(e)(3) or 227.7203-6(c), use the following clause: Validation of Asserted Restrictions—Computer Software (JUN 1995) (a) Definitions. (1) As used in this clause...

48 CFR 52.227-15 - Representation of Limited Rights Data and Restricted Computer Software.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Rights Data and Restricted Computer Software. 52.227-15 Section 52.227-15 Federal Acquisition Regulations... Computer Software. As prescribed in 27.409(c), insert the following provision: Representation of Limited Rights Data and Restricted Computer Software (DEC 2007) (a) This solicitation sets forth the Government's...

48 CFR 252.227-7019 - Validation of asserted restrictions-Computer software.

Code of Federal Regulations, 2011 CFR

2011-10-01

... restrictions-Computer software. 252.227-7019 Section 252.227-7019 Federal Acquisition Regulations System...—Computer software. As prescribed in 227.7104(e)(3) or 227.7203-6(c), use the following clause: Validation of Asserted Restrictions—Computer Software (SEP 2011) (a) Definitions. (1) As used in this clause...

48 CFR 252.227-7026 - Deferred delivery of technical data or computer software.

Code of Federal Regulations, 2012 CFR

2012-10-01

... technical data or computer software. 252.227-7026 Section 252.227-7026 Federal Acquisition Regulations... data or computer software. As prescribed at 227.7103-8(a), use the following clause: Deferred Delivery of Technical Data or Computer Software (APR 1988) The Government shall have the right to require, at...

48 CFR 252.227-7025 - Limitations on the Use or Disclosure of Government-Furnished Information Marked with Restrictive...

Code of Federal Regulations, 2013 CFR

2013-10-01

... contracts in which the Government will furnish the Contractor with computer software or computer software... rights” are defined in the clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation. (3) For Small Business Innovation Research program contracts, the...

48 CFR 252.227-7019 - Validation of asserted restrictions-Computer software.

Code of Federal Regulations, 2012 CFR

2012-10-01

... restrictions-Computer software. 252.227-7019 Section 252.227-7019 Federal Acquisition Regulations System...—Computer software. As prescribed in 227.7104(e)(3) or 227.7203-6(c), use the following clause: Validation of Asserted Restrictions—Computer Software (SEP 2011) (a) Definitions. (1) As used in this clause...

48 CFR 52.227-15 - Representation of Limited Rights Data and Restricted Computer Software.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Rights Data and Restricted Computer Software. 52.227-15 Section 52.227-15 Federal Acquisition Regulations... Computer Software. As prescribed in 27.409(c), insert the following provision: Representation of Limited Rights Data and Restricted Computer Software (DEC 2007) (a) This solicitation sets forth the Government's...

48 CFR 27.404-2 - Limited rights data and restricted computer software.

Code of Federal Regulations, 2013 CFR

2013-10-01

... restricted computer software. 27.404-2 Section 27.404-2 Federal Acquisition Regulations System FEDERAL... Copyrights 27.404-2 Limited rights data and restricted computer software. (a) General. The basic clause at 52... restricted computer software by withholding the data from the Government and instead delivering form, fit...

48 CFR 52.227-15 - Representation of Limited Rights Data and Restricted Computer Software.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Rights Data and Restricted Computer Software. 52.227-15 Section 52.227-15 Federal Acquisition Regulations... Computer Software. As prescribed in 27.409(c), insert the following provision: Representation of Limited Rights Data and Restricted Computer Software (DEC 2007) (a) This solicitation sets forth the Government's...

48 CFR 252.227-7026 - Deferred delivery of technical data or computer software.

Code of Federal Regulations, 2014 CFR

2014-10-01

... technical data or computer software. 252.227-7026 Section 252.227-7026 Federal Acquisition Regulations... data or computer software. As prescribed at 227.7103-8(a), use the following clause: Deferred Delivery of Technical Data or Computer Software (APR 1988) The Government shall have the right to require, at...

48 CFR 252.227-7025 - Limitations on the use or disclosure of government-furnished information marked with restrictive...

Code of Federal Regulations, 2012 CFR

2012-10-01

... contracts in which the Government will furnish the Contractor with computer software or computer software... rights” are defined in the clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation. (3) For Small Business Innovation Research program contracts, the...

48 CFR 252.227-7019 - Validation of asserted restrictions-Computer software.

Code of Federal Regulations, 2014 CFR

2014-10-01

... restrictions-Computer software. 252.227-7019 Section 252.227-7019 Federal Acquisition Regulations System...—Computer software. As prescribed in 227.7104(e)(3) or 227.7203-6(c), use the following clause: Validation of Asserted Restrictions—Computer Software (SEP 2011) (a) Definitions. (1) As used in this clause...

48 CFR 252.227-7026 - Deferred delivery of technical data or computer software.

Code of Federal Regulations, 2011 CFR

2011-10-01

... technical data or computer software. 252.227-7026 Section 252.227-7026 Federal Acquisition Regulations... data or computer software. As prescribed at 227.7103-8(a), use the following clause: Deferred Delivery of Technical Data or Computer Software (APR 1988) The Government shall have the right to require, at...

48 CFR 252.227-7025 - Limitations on the Use or Disclosure of Government-Furnished Information Marked with Restrictive...

Code of Federal Regulations, 2014 CFR

2014-10-01

... contracts in which the Government will furnish the Contractor with computer software or computer software... rights” are defined in the clause at 252.227-7014, Rights in Noncommercial Computer Software and Noncommercial Computer Software Documentation. (3) For Small Business Innovation Research program contracts, the...

48 CFR 252.227-7019 - Validation of asserted restrictions-Computer software.

Code of Federal Regulations, 2013 CFR

2013-10-01

... restrictions-Computer software. 252.227-7019 Section 252.227-7019 Federal Acquisition Regulations System...—Computer software. As prescribed in 227.7104(e)(3) or 227.7203-6(c), use the following clause: Validation of Asserted Restrictions—Computer Software (SEP 2011) (a) Definitions. (1) As used in this clause...

48 CFR 252.227-7026 - Deferred delivery of technical data or computer software.

Code of Federal Regulations, 2013 CFR

2013-10-01

... technical data or computer software. 252.227-7026 Section 252.227-7026 Federal Acquisition Regulations... data or computer software. As prescribed at 227.7103-8(a), use the following clause: Deferred Delivery of Technical Data or Computer Software (APR 1988) The Government shall have the right to require, at...

48 CFR 27.404-2 - Limited rights data and restricted computer software.

Code of Federal Regulations, 2010 CFR

2010-10-01

... restricted computer software. 27.404-2 Section 27.404-2 Federal Acquisition Regulations System FEDERAL... Copyrights 27.404-2 Limited rights data and restricted computer software. (a) General. The basic clause at 52... restricted computer software by withholding the data from the Government and instead delivering form, fit...

LENR BEC Clusters on and below Wires through Cavitation and Related Techniques

NASA Astrophysics Data System (ADS)

Stringham, Roger; Stringham, Julie

2011-03-01

During the last two years I have been working on BEC cluster densities deposited just under the surface of wires, using cavitation, and other techniques. If I get the concentration high enough before the clusters dissipate, in addition to cold fusion related excess heat (and other effects, including helium-4 formation) I anticipate that it may be possible to initiate transient forms of superconductivity at room temperature.

Investigation of the coupling of the momentum distribution of a BEC with its collective of modes

NASA Astrophysics Data System (ADS)

Henn, Emanuel; Tavares, Pedro; Fritsch, Amilson; Vivanco, Franklin; Telles, Gustavo; Bagnato, Vanderlei

In our group we have a strong research line on quantum turbulence and the general investigation of Bose-Einstein condensates (BEC) subjected to oscillatory excitations. Inside this research line we investigate first the behavior of the normal modes of the BEC under this excitation and observe a non-linear behavior in the amplitude of the quadrupolar mode. Also, inside this same procedure of investigation we study the momentum distribution of a BEC to understand if it is possible to extract Kolmogorov like excitation spectra which would point to a turbulent state of matter. The condensate is perturbed, and we let it evolve in-trap after which we perform standard time-of- flight absorption imaging. The momentum distribution is extracted and analyzed as a function of the in-trap free evolution time for a 2D projected cloud. We show that the momentum distribution has its features varying periodically with the same frequency as the quadrupolar mode displayed by the atomic gas hinting at a strong coupling of both. The main consequence of that one cannot be assertive about the quantitative features of the extract spectrum of momentum and we can only rely on its qualitative features. Financial Support: FAPESP, CNPq.

Einstein Critical-Slowing-Down is Siegel CyberWar Denial-of-Access Queuing/Pinning/ Jamming/Aikido Via Siegel DIGIT-Physics BEC ``Intersection''-BECOME-UNION Barabasi Network/GRAPH-Physics BEC: Strutt/Rayleigh-Siegel Percolation GLOBALITY-to-LOCALITY Phase-Transition Critical-Phenomenon

NASA Astrophysics Data System (ADS)

Buick, Otto; Falcon, Pat; Alexander, G.; Siegel, Edward Carl-Ludwig

2013-03-01

Einstein[Dover(03)] critical-slowing-down(CSD)[Pais, Subtle in The Lord; Life & Sci. of Albert Einstein(81)] is Siegel CyberWar denial-of-access(DOA) operations-research queuing theory/pinning/jamming/.../Read [Aikido, Aikibojitsu & Natural-Law(90)]/Aikido(!!!) phase-transition critical-phenomenon via Siegel DIGIT-Physics (Newcomb[Am.J.Math. 4,39(1881)]-{Planck[(1901)]-Einstein[(1905)])-Poincare[Calcul Probabilités(12)-p.313]-Weyl [Goett.Nachr.(14); Math.Ann.77,313 (16)]-{Bose[(24)-Einstein[(25)]-Fermi[(27)]-Dirac[(1927)]}-``Benford''[Proc.Am.Phil.Soc. 78,4,551 (38)]-Kac[Maths.Stat.-Reasoning(55)]-Raimi[Sci.Am. 221,109 (69)...]-Jech[preprint, PSU(95)]-Hill[Proc.AMS 123,3,887(95)]-Browne[NYT(8/98)]-Antonoff-Smith-Siegel[AMS Joint-Mtg.,S.-D.(02)] algebraic-inversion to yield ONLY BOSE-EINSTEIN QUANTUM-statistics (BEQS) with ZERO-digit Bose-Einstein CONDENSATION(BEC) ``INTERSECTION''-BECOME-UNION to Barabasi[PRL 876,5632(01); Rev.Mod.Phys.74,47(02)...] Network /Net/GRAPH(!!!)-physics BEC: Strutt/Rayleigh(1881)-Polya(21)-``Anderson''(58)-Siegel[J.Non-crystalline-Sol.40,453(80)

The Regulation of Medical Computer Software as a “Device” under the Food, Drug, and Cosmetic Act

PubMed Central

Brannigan, Vincent

1986-01-01

Recent developments in computer software have raised the possibility that federal regulators may claim to control medical computer software as a “device” under the Food, Drug and Cosmetic Act. The purpose of this paper is to analyze the FDCA to determine whether computer software is included in the statutory scheme, examine constitutional arguments relating to computer software, and discuss regulatory principles that should be taken into account when deciding appropriate regulation. This paper is limited to computer program output used by humans in deciding appropriate medical therapy for a patient.

48 CFR 352.227-14 - Rights in Data-Exceptional Circumstances.

Code of Federal Regulations, 2014 CFR

2014-10-01

....] Computer database or database means a collection of recorded information in a form capable of, and for the... databases or computer software documentation. Computer software documentation means owner's manuals, user's... nature (including computer databases and computer software documentation). This term does not include...

48 CFR 227.7203-5 - Government rights.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Software and Computer Software Documentation 227.7203-5 Government rights. The standard license rights in computer software that a licensor grants to the Government are unlimited rights, government purpose rights, or restricted rights. The standard license in computer software documentation conveys unlimited...

48 CFR 227.7203-5 - Government rights.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Software and Computer Software Documentation 227.7203-5 Government rights. The standard license rights in computer software that a licensor grants to the Government are unlimited rights, government purpose rights, or restricted rights. The standard license in computer software documentation conveys unlimited...

48 CFR 227.7203-5 - Government rights.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Software and Computer Software Documentation 227.7203-5 Government rights. The standard license rights in computer software that a licensor grants to the Government are unlimited rights, government purpose rights, or restricted rights. The standard license in computer software documentation conveys unlimited...

48 CFR 227.7203-5 - Government rights.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Software and Computer Software Documentation 227.7203-5 Government rights. The standard license rights in computer software that a licensor grants to the Government are unlimited rights, government purpose rights, or restricted rights. The standard license in computer software documentation conveys unlimited...

48 CFR 227.7203-5 - Government rights.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Software and Computer Software Documentation 227.7203-5 Government rights. The standard license rights in computer software that a licensor grants to the Government are unlimited rights, government purpose rights, or restricted rights. The standard license in computer software documentation conveys unlimited...

48 CFR 27.405-3 - Commercial computer software.

Code of Federal Regulations, 2011 CFR

2011-10-01

... software. 27.405-3 Section 27.405-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Commercial computer software. (a) When contracting other than from GSA's Multiple Award Schedule contracts for the acquisition of commercial computer software, no specific contract clause prescribed in this...

48 CFR 27.405-3 - Commercial computer software.

Code of Federal Regulations, 2012 CFR

2012-10-01

... software. 27.405-3 Section 27.405-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Commercial computer software. (a) When contracting other than from GSA's Multiple Award Schedule contracts for the acquisition of commercial computer software, no specific contract clause prescribed in this...

48 CFR 27.405-3 - Commercial computer software.

Code of Federal Regulations, 2014 CFR

2014-10-01

... software. 27.405-3 Section 27.405-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Commercial computer software. (a) When contracting other than from GSA's Multiple Award Schedule contracts for the acquisition of commercial computer software, no specific contract clause prescribed in this...

48 CFR 27.405-3 - Commercial computer software.

Code of Federal Regulations, 2013 CFR

2013-10-01

... software. 27.405-3 Section 27.405-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Commercial computer software. (a) When contracting other than from GSA's Multiple Award Schedule contracts for the acquisition of commercial computer software, no specific contract clause prescribed in this...

48 CFR 27.405-3 - Commercial computer software.

Code of Federal Regulations, 2010 CFR

2010-10-01

... software. 27.405-3 Section 27.405-3 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION... Commercial computer software. (a) When contracting other than from GSA's Multiple Award Schedule contracts for the acquisition of commercial computer software, no specific contract clause prescribed in this...

Chaotic vortex filaments in a Bose–Einstein condensate and in superfluid helium

NASA Astrophysics Data System (ADS)

Nemirovskii, S. K.

2018-05-01

A statement of the quantum turbulence problem in both a Bose–Einstein condensate (BEC) and superfluid helium is formulated. In superfluid helium use is made of a so-called vortex filament method, in which quantum vortices are represented by stringlike objects, i.e. vortex lines. The dynamics of the vortex lines is determined by deterministic equations of motion, supplemented by random reconnections. Unlike He II, the laws of the dynamics of quantum vortices in BEC are based on the nonlinear Schrödinger equation. This makes it possible to obtain a microscopic description of the collision of vortices, the structure of a vortex filament, etc. A comparative analysis of these complementary approaches is carried out. It is shown that there are some features that do not automatically transfer the results obtained for BEC to vortices in He II and vice versa.

Strong-Coupling Effects and Shear Viscosity in an Ultracold Fermi Gas

NASA Astrophysics Data System (ADS)

Kagamihara, D.; Ohashi, Y.

2017-06-01

We theoretically investigate the shear viscosity η , as well as the entropy density s, in the normal state of an ultracold Fermi gas. Including pairing fluctuations within the framework of a T-matrix approximation, we calculate these quantities in the Bardeen-Cooper-Schrieffer (BCS)-Bose-Einstein condensation (BEC) crossover region. We also evaluate η / s, to compare it with the lower bound of this ratio, conjectured by Kovtun, Son, and Starinets (KSS bound). In the weak-coupling BCS side, we show that the shear viscosity η is remarkably suppressed near the superfluid phase transition temperature Tc, due to the so-called pseudogap phenomenon. In the strong-coupling BEC side, we find that, within the neglect of the vertex corrections, one cannot correctly describe η . We also show that η / s decreases with increasing the interaction strength, to become very close to the KSS bound, \\hbar /4π kB, on the BEC side.

Dynamics of vortices followed by the collapse of ring dark solitons in a two-component Bose-Einstein condensate

NASA Astrophysics Data System (ADS)

Wang, Lin-Xue; Dai, Chao-Qing; Wen, Lin; Liu, Tao; Jiang, Hai-Feng; Saito, Hiroki; Zhang, Shou-Gang; Zhang, Xiao-Fei

2018-06-01

We explore the effects of system parameters on the dynamics of ring dark solitons (RDSs) and vortices followed by the collapse of RDSs in a two-component Bose-Einstein condensate (BEC). The system exhibits complicated dynamical behaviors, which are quite different from those in a scalar BEC. For two shallow RDSs with equal initial depths, the dynamical trajectories of generated vortex dipoles are similar to those in a scalar BEC, but the time for vortex dipoles to perform a periodic motion is increased. In particular, there exists a critical depth, above which vortex dipoles first move along the vertical direction and then preform complicated dynamics, including their rearrangement and recombination. Finally, we consider the case of unequal initial depths and find that the number of created vortices is determined by the depth of the shallow RDS, while their initial moving direction is determined by the deeper one.

Cooling flexural modes of a mechanical oscillator by magnetically trapped Bose-Einstein-condensate atoms

NASA Astrophysics Data System (ADS)

Xu, Donghong; Xue, Fei

2017-12-01

We theoretically study cooling of flexural modes of a mechanical oscillator by Bose-Einstein-condensate (BEC) atoms (Rb87) trapped in a magnetic trap. The mechanical oscillator with a tiny magnet attached on one of its free ends produces an oscillating magnetic field. When its oscillating frequency matches certain hyperfine Zeeman energy of Rb87 atoms, the trapped BEC atoms are coupled out of the magnetic trap by the mechanical oscillator, flying away from the trap with stolen energy from the mechanical oscillator. Thus the mode temperature of the mechanical oscillator is reduced. The mode temperature of the steady state of mechanical oscillator, measured by the mean steady-state phonon number in the flexural mode of the mechanical oscillator, is analyzed. It is found that ground state (phonon number less than 1) may be accessible with optimal parameters of the hybrid system of mechanical oscillator and trapped BEC atoms.

Singular Atom Optics with Spinor BECs

NASA Astrophysics Data System (ADS)

Schultz, Justin T.; Hansen, Azure; Bigelow, Nicholas P.

2015-05-01

We create and study singular spin textures in pseudo-spin-1/2 BECs. A series of two-photon Raman interactions allows us to not only engineer the spinor wavefunction but also perform the equivalent of atomic polarimetry on the BEC. Adapting techniques from optical polarimetry, we can image two-dimensional maps of the atomic Stokes parameters, thereby fully reconstructing the atomic wavefunction. In a spin-1/2 system, we can represent the local spin superposition with ellipses in a Cartesian basis. The patterns that emerge from the major axes of the ellipses provide fingerprints of the singularities that enable us to classify them as lemons, stars, saddles, or spirals similar to classification schemes for singularities in singular optics, condensed matter, and liquid crystals. These techniques may facilitate the study of geometric Gouy phases in matter waves as well as provide an avenue for utilizing topological structures as quantum gates.

Core structure and dynamics of non-Abelian vortices in a biaxial nematic spinor Bose-Einstein condensate

NASA Astrophysics Data System (ADS)

Borgh, Magnus O.; Ruostekoski, Janne

2016-05-01

We demonstrate that multiple interaction-dependent defect core structures as well as dynamics of non-Abelian vortices can be realized in the biaxial nematic (BN) phase of a spin-2 atomic Bose-Einstein condensate (BEC). An experimentally simple protocol may be used to break degeneracy with the uniaxial nematic phase. We show that a discrete spin-space symmetry in the core may be reflected in a breaking of its spatial symmetry. The discrete symmetry of the BN order parameter leads to non-commuting vortex charges. We numerically simulate reconnection of non-Abelian vortices, demonstrating formation of the obligatory rung vortex. In addition to atomic BECs, non-Abelian vortices are theorized in, e.g., liquid crystals and cosmic strings. Our results suggest the BN spin-2 BEC as a prime candidate for their realization. We acknowledge financial support from the EPSRC.

Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver disease

PubMed Central

Demetris, A J; III, John G Lunz; Specht, Susan; Nozaki, Isao

2006-01-01

Basic and translational wound healing research in the biliary tree lag significantly behind similar studies on the skin and gastrointestinal tract. This is at least partly attributable to lack of easy access to the biliary tract for study. But clinical relevance, more interest in biliary epithelial cell (BEC) pathophysiology, and widespread availability of BEC cultures are factors reversing this trend. In the extra-hepatic biliary tree, ineffectual wound healing, scarring and stricture development are pressing issues. In the smallest intra-hepatic bile ducts either impaired BEC proliferation or an exuberant response can contribute to liver disease. Chronic inflammation and persistent wound healing reactions in large and small bile ducts often lead to liver cancer. General concepts of wound healing as they apply to the biliary tract, importance of cellular processes dependent on IL-6/gp130/STAT3 signaling pathways, unanswered questions, and future directions are discussed. PMID:16773708

The 120-S minute: using analysis of work activity to prevent psychological distress among elementary school teachers.

PubMed

Messing, K; Seifert, A M; Escalona, E

1997-01-01

Primary school teachers in Québec suffer psychological distress, as shown by the Québec Health Survey (M. Gervais, 1993; Santè Québec, 1995). The authors applied and extended the French model (F. Guérin, A. Laville, F. Daniellou, J. Duraffourg, & A. Kerguelen, 1991) of analysis of work activity to observing classroom teaching (14 women in 10 classrooms for a total of 48 hr 24 min) to identify stressful elements. The authors observed a rapid sequence of actions, eye fixations of short duration, little physical or mental relaxation, multiple simultaneous activities, and uncomfortable temperature and humidity levels. Teachers use many strategies to teach, to create a learning environment, and to maintain attention in classrooms under adverse conditions. Examination of these strategies led to recommendations to improve relations between the teachers and their supervisors and to make the classroom an easier place to teach.

{sup 85}Rb tunable-interaction Bose-Einstein condensate machine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Altin, P. A.; Robins, N. P.; Doering, D.

We describe our experimental setup for creating stable Bose-Einstein condensates (BECs) of {sup 85}Rb with tunable interparticle interactions. We use sympathetic cooling with {sup 87}Rb in two stages, initially in a tight Ioffe-Pritchard magnetic trap and subsequently in a weak, large-volume, crossed optical dipole trap, using the 155 G Feshbach resonance to manipulate the elastic and inelastic scattering properties of the {sup 85}Rb atoms. Typical {sup 85}Rb condensates contain 4x10{sup 4} atoms with a scattering length of a=+200a{sub 0}. Many aspects of the design presented here could be adapted to other dual-species BEC machines, including those involving degenerate Fermi-Bose mixtures.more » Our minimalist apparatus is well suited to experiments on dual-species and spinor Rb condensates, and has several simplifications over the {sup 85}Rb BEC machine at JILA, which we discuss at the end of this article.« less

Quasiparticle lifetime in a mixture of Bose and Fermi superfluids.

PubMed

Zheng, Wei; Zhai, Hui

2014-12-31

In this Letter, we study the effect of quasiparticle interactions in a Bose-Fermi superfluid mixture. We consider the lifetime of a quasiparticle of the Bose superfluid due to its interaction with quasiparticles in the Fermi superfluid. We find that this damping rate, i.e., the inverse of the lifetime, has quite a different threshold behavior at the BCS and the BEC side of the Fermi superfluid. The damping rate is a constant near the threshold momentum in the BCS side, while it increases rapidly in the BEC side. This is because, in the BCS side, the decay process is restricted by the constraint that the fermion quasiparticle is located near the Fermi surface, while such a restriction does not exist in the BEC side where the damping process is dominated by bosonic quasiparticles of the Fermi superfluid. Our results are related to the collective mode experiment in the recently realized Bose-Fermi superfluid mixture.

Trends in computer hardware and software.

PubMed

Frankenfeld, F M

1993-04-01

Previously identified and current trends in the development of computer systems and in the use of computers for health care applications are reviewed. Trends identified in a 1982 article were increasing miniaturization and archival ability, increasing software costs, increasing software independence, user empowerment through new software technologies, shorter computer-system life cycles, and more rapid development and support of pharmaceutical services. Most of these trends continue today. Current trends in hardware and software include the increasing use of reduced instruction-set computing, migration to the UNIX operating system, the development of large software libraries, microprocessor-based smart terminals that allow remote validation of data, speech synthesis and recognition, application generators, fourth-generation languages, computer-aided software engineering, object-oriented technologies, and artificial intelligence. Current trends specific to pharmacy and hospitals are the withdrawal of vendors of hospital information systems from the pharmacy market, improved linkage of information systems within hospitals, and increased regulation by government. The computer industry and its products continue to undergo dynamic change. Software development continues to lag behind hardware, and its high cost is offsetting the savings provided by hardware.

48 CFR 52.227-19 - Commercial Computer Software License.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Software License. 52.227-19 Section 52.227-19 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.227-19 Commercial Computer Software License. As prescribed in 27.409(g), insert the following clause: Commercial Computer Software License (DEC 2007) (a) Notwithstanding any contrary provisions...

48 CFR 52.227-19 - Commercial Computer Software License.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Software License. 52.227-19 Section 52.227-19 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.227-19 Commercial Computer Software License. As prescribed in 27.409(g), insert the following clause: Commercial Computer Software License (DEC 2007) (a) Notwithstanding any contrary provisions...

48 CFR 52.227-19 - Commercial Computer Software License.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Software License. 52.227-19 Section 52.227-19 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.227-19 Commercial Computer Software License. As prescribed in 27.409(g), insert the following clause: Commercial Computer Software License (DEC 2007) (a) Notwithstanding any contrary provisions...

48 CFR 52.227-19 - Commercial Computer Software License.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Software License. 52.227-19 Section 52.227-19 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.227-19 Commercial Computer Software License. As prescribed in 27.409(g), insert the following clause: Commercial Computer Software License (DEC 2007) (a) Notwithstanding any contrary provisions...

48 CFR 52.227-19 - Commercial Computer Software License.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Software License. 52.227-19 Section 52.227-19 Federal Acquisition Regulations System FEDERAL ACQUISITION... Clauses 52.227-19 Commercial Computer Software License. As prescribed in 27.409(g), insert the following clause: Commercial Computer Software License (DEC 2007) (a) Notwithstanding any contrary provisions...

10 CFR 961.11 - Text of the contract.

Code of Federal Regulations, 2014 CFR

2014-01-01

... program including information on cost projections, project plans and progress reports. 5. (a) Beginning on...-type documents or computer software (including computer programs, computer software data bases, and computer software documentation). Examples of technical data include research and engineering data...

10 CFR 961.11 - Text of the contract.

Code of Federal Regulations, 2013 CFR

2013-01-01

... program including information on cost projections, project plans and progress reports. 5. (a) Beginning on...-type documents or computer software (including computer programs, computer software data bases, and computer software documentation). Examples of technical data include research and engineering data...

Microcomputer software development facilities

NASA Technical Reports Server (NTRS)

Gorman, J. S.; Mathiasen, C.

1980-01-01

A more efficient and cost effective method for developing microcomputer software is to utilize a host computer with high-speed peripheral support. Application programs such as cross assemblers, loaders, and simulators are implemented in the host computer for each of the microcomputers for which software development is a requirement. The host computer is configured to operate in a time share mode for multiusers. The remote terminals, printers, and down loading capabilities provided are based on user requirements. With this configuration a user, either local or remote, can use the host computer for microcomputer software development. Once the software is developed (through the code and modular debug stage) it can be downloaded to the development system or emulator in a test area where hardware/software integration functions can proceed. The microcomputer software program sources reside in the host computer and can be edited, assembled, loaded, and then downloaded as required until the software development project has been completed.

Software For Computing Reliability Of Other Software

NASA Technical Reports Server (NTRS)

Nikora, Allen; Antczak, Thomas M.; Lyu, Michael

1995-01-01

Computer Aided Software Reliability Estimation (CASRE) computer program developed for use in measuring reliability of other software. Easier for non-specialists in reliability to use than many other currently available programs developed for same purpose. CASRE incorporates mathematical modeling capabilities of public-domain Statistical Modeling and Estimation of Reliability Functions for Software (SMERFS) computer program and runs in Windows software environment. Provides menu-driven command interface; enabling and disabling of menu options guides user through (1) selection of set of failure data, (2) execution of mathematical model, and (3) analysis of results from model. Written in C language.

48 CFR 239.101 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

.... See Subpart 208.74 when acquiring commercial software or software maintenance. See 227.7202 for policy on the acquisition of commercial computer software and commercial computer software documentation...

48 CFR 239.101 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

.... See Subpart 208.74 when acquiring commercial software or software maintenance. See 227.7202 for policy on the acquisition of commercial computer software and commercial computer software documentation...

48 CFR 239.101 - Policy.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... See Subpart 208.74 when acquiring commercial software or software maintenance. See 227.7202 for policy on the acquisition of commercial computer software and commercial computer software documentation...

48 CFR 239.101 - Policy.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... See Subpart 208.74 when acquiring commercial software or software maintenance. See 227.7202 for policy on the acquisition of commercial computer software and commercial computer software documentation...

48 CFR 239.101 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

.... See Subpart 208.74 when acquiring commercial software or software maintenance. See 227.7202 for policy on the acquisition of commercial computer software and commercial computer software documentation...

37 CFR 201.26 - Recordation of documents pertaining to computer shareware and donation of public domain computer...

Code of Federal Regulations, 2014 CFR

2014-07-01

... pertaining to computer shareware and donation of public domain computer software. 201.26 Section 201.26... of public domain computer software. (a) General. This section prescribes the procedures for... software under section 805 of Public Law 101-650, 104 Stat. 5089 (1990). Documents recorded in the...

Building an ensemble of climate scenarios for decision-making in hydrology: benefits, pitfalls and uncertainties

NASA Astrophysics Data System (ADS)

Braun, Marco; Chaumont, Diane

2013-04-01

Using climate model output to explore climate change impacts on hydrology requires several considerations, choices and methods in the post treatment of the datasets. In the effort of producing a comprehensive data base of climate change scenarios for over 300 watersheds in the Canadian province of Québec, a selection of state of the art procedures were applied to an ensemble comprising 87 climate simulations. The climate data ensemble is based on global climate simulations from the Coupled Model Intercomparison Project - Phase 3 (CMIP3) and regional climate simulations from the North American Regional Climate Change Assessment Program (NARCCAP) and operational simulations produced at Ouranos. Information on the response of hydrological systems to changing climate conditions can be derived by linking climate simulations with hydrological models. However, the direct use of raw climate model output variables as drivers for hydrological models is limited by issues such as spatial resolution and the calibration of hydro models with observations. Methods for downscaling and bias correcting the data are required to achieve seamless integration of climate simulations with hydro models. The effects on the results of four different approaches to data post processing were explored and compared. We present the lessons learned from building the largest data base yet for multiple stakeholders in the hydro power and water management sector in Québec putting an emphasis on the benefits and pitfalls in choosing simulations, extracting the data, performing bias corrections and documenting the results. A discussion of the sources and significance of uncertainties in the data will also be included. The climatological data base was subsequently used by the state owned hydro power company Hydro-Québec and the Centre d'expertise hydrique du Québec (CEHQ), the provincial water authority, to simulate future stream flows and analyse the impacts on hydrological indicators. While this submission focuses on the production of climatic scenarios for application in hydrology, the submission « The (cQ)2 project: assessing watershed scale hydrological changes for the province of Québec at the 2050 horizon, a collaborative framework » by Catherine Guay describes how Hydro-Québec and CEHQ put the data into use.

Stable subcutaneous cartilage regeneration of bone marrow stromal cells directed by chondrocyte sheet.

PubMed

Li, Dan; Zhu, Lian; Liu, Yu; Yin, Zongqi; Liu, Yi; Liu, Fangjun; He, Aijuan; Feng, Shaoqing; Zhang, Yixin; Zhang, Zhiyong; Zhang, Wenjie; Liu, Wei; Cao, Yilin; Zhou, Guangdong

2017-05-01

In vivo niche plays an important role in regulating differentiation fate of stem cells. Due to lack of proper chondrogenic niche, stable cartilage regeneration of bone marrow stromal cells (BMSCs) in subcutaneous environments is always a great challenge. This study explored the feasibility that chondrocyte sheet created chondrogenic niche retained chondrogenic phenotype of BMSC engineered cartilage (BEC) in subcutaneous environments. Porcine BMSCs were seeded into biodegradable scaffolds followed by 4weeks of chondrogenic induction in vitro to form BEC, which were wrapped with chondrocyte sheets (Sheet group), acellular small intestinal submucosa (SIS, SIS group), or nothing (Blank group) respectively and then implanted subcutaneously into nude mice to trace the maintenance of chondrogenic phenotype. The results showed that all the constructs in Sheet group displayed typical cartilaginous features with abundant lacunae and cartilage specific matrices deposition. These samples became more mature with prolonged in vivo implantation, and few signs of ossification were observed at all time points except for one sample that had not been wrapped completely. Cell labeling results in Sheet group further revealed that the implanted BEC directly participated in cartilage formation. Samples in both SIS and Blank groups mainly showed ossified tissue at all time points with partial fibrogenesis in a few samples. These results suggested that chondrocyte sheet could create a chondrogenic niche for retaining chondrogenic phenotype of BEC in subcutaneous environment and thus provide a novel research model for stable ectopic cartilage regeneration based on stem cells. In vivo niche plays an important role in directing differentiation fate of stem cells. Due to lack of proper chondrogenic niche, stable cartilage regeneration of bone marrow stromal cells (BMSCs) in subcutaneous environments is always a great challenge. The current study demonstrated that chondrocyte sheet generated by high-density culture of chondrocytes in vitro could cearte a chondrogenic niche in subcutaneous environment and efficiently retain the chondrogenic phenotype of in vitro BMSC engineered cartilage (vitro-BEC). Furthermore, cell tracing results revealed that the regenerated cartilage mainly derived from the implanted vitro-BEC. The current study not only proposes a novel research model for microenvironment simulation but also provides a useful strategy for stable ectopic cartilage regeneration of stem cells. Copyright © 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

77 FR 50723 - Verification, Validation, Reviews, and Audits for Digital Computer Software Used in Safety...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-22

... Digital Computer Software Used in Safety Systems of Nuclear Power Plants AGENCY: Nuclear Regulatory..., ``Verification, Validation, Reviews, and Audits for Digital Computer Software used in Safety Systems of Nuclear... NRC regulations promoting the development of, and compliance with, software verification and...

48 CFR 970.5227-1 - Rights in data-facilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... software. (2) Computer software, as used in this clause, means (i) computer programs which are data... software. The term “data” does not include data incidental to the administration of this contract, such as... this clause, means data, other than computer software, developed at private expense that embody trade...

An ensemble approach to assess hydrological models' contribution to uncertainties in the analysis of climate change impact on water resources

NASA Astrophysics Data System (ADS)

Velázquez, J. A.; Schmid, J.; Ricard, S.; Muerth, M. J.; Gauvin St-Denis, B.; Minville, M.; Chaumont, D.; Caya, D.; Ludwig, R.; Turcotte, R.

2012-06-01

Over the recent years, several research efforts investigated the impact of climate change on water resources for different regions of the world. The projection of future river flows is affected by different sources of uncertainty in the hydro-climatic modelling chain. One of the aims of the QBic3 project (Québec-Bavarian International Collaboration on Climate Change) is to assess the contribution to uncertainty of hydrological models by using an ensemble of hydrological models presenting a diversity of structural complexity (i.e. lumped, semi distributed and distributed models). The study investigates two humid, mid-latitude catchments with natural flow conditions; one located in Southern Québec (Canada) and one in Southern Bavaria (Germany). Daily flow is simulated with four different hydrological models, forced by outputs from regional climate models driven by a given number of GCMs' members over a reference (1971-2000) and a future (2041-2070) periods. The results show that the choice of the hydrological model does strongly affect the climate change response of selected hydrological indicators, especially those related to low flows. Indicators related to high flows seem less sensitive on the choice of the hydrological model. Therefore, the computationally less demanding models (usually simple, lumped and conceptual) give a significant level of trust for high and overall mean flows.

Satellite-tracking and Earth dynamics research programs

NASA Technical Reports Server (NTRS)

1982-01-01

The activities carried out by the Smithsonian Astrophysical Observatory (SAO) are described. The SAO network continued to track LAGEOS at highest priority for polar motion and Earth rotation studies, and for other geophysical investigations, including crustal dynamics, Earth and ocean tides, and the general development of precision orbit determination. The network performed regular tracking of several other retroreflector satellites including GEOS-1, GEOS-3, BE-C, and Starlette for refined determinations of station coordinates and the Earth's gravity field and for studies of solid Earth dynamics. A major program in laser upgrading continued to improve ranging accuracy and data yield. This program includes an increase in pulse repetition rate from 8 ppm to 30 ppm, a reduction in laser pulse width from 6 nsec to 2 to 3 nsec, improvements in the photoreceiver and the electronics to improve daylight ranging, and an analog pulse detection system to improve range noise and accuracy. Data processing hardware and software are discussed.

Onsager vortex formation in two-component Bose–Einstein condensates in two-dimensional traps

NASA Astrophysics Data System (ADS)

Han, Junsik; Tsubota, Makoto

2018-03-01

We study numerically the dynamics of quantized vortices in two-dimensional one-component and two-component Bose–Einstein condensates (BECs) trapped by a harmonic and box potentials. In two-component miscible BECs, we confirmed the tendency of the formation of Onsager vortices in both traps. The vortices in one component separate spatially from those in the other component, which comes from their intercomponent-coupling. We also discuss the decay of the number of vortices.

Distribution of sulfonamide resistance genes in Escherichia coli and Salmonella isolates from swine and chickens at abattoirs in Ontario and Québec, Canada.

PubMed

Kozak, Gosia K; Pearl, David L; Parkman, Julia; Reid-Smith, Richard J; Deckert, Anne; Boerlin, Patrick

2009-09-01

Sulfonamide-resistant Escherichia coli and Salmonella isolates from pigs and chickens in Ontario and Québec were screened for sul1, sul2, and sul3 by PCR. Each sul gene was distributed differently across populations, with a significant difference between distribution in commensal E. coli and Salmonella isolates and sul3 restricted mainly to porcine E. coli isolates.

Distribution of Sulfonamide Resistance Genes in Escherichia coli and Salmonella Isolates from Swine and Chickens at Abattoirs in Ontario and Québec, Canada ▿

PubMed Central

Kozak, Gosia K.; Pearl, David L.; Parkman, Julia; Reid-Smith, Richard J.; Deckert, Anne; Boerlin, Patrick

2009-01-01

Sulfonamide-resistant Escherichia coli and Salmonella isolates from pigs and chickens in Ontario and Québec were screened for sul1, sul2, and sul3 by PCR. Each sul gene was distributed differently across populations, with a significant difference between distribution in commensal E. coli and Salmonella isolates and sul3 restricted mainly to porcine E. coli isolates. PMID:19633109

Thermo-optically induced interactions in photon Bose-Einstein Condensates

NASA Astrophysics Data System (ADS)

Alaeian, Hadiseh; Bartels, Clara; Weitz, Martin

Bose-Einstein condensation (BEC), a new state of matter, emerges when the de Broglie wavelength of bosons becomes larger than the particle separation, leading to a macroscopic occupation of the system ground state. Followed by the first experimental demonstrations of BEC in cold atomic gases, this phase transition has been observed in other bosonic gases, as polaritons and phonons. The most recent one, photon BEC, is a promising candidate for a new generation of coherent photon sources. Due to their infancy, however, many of their properties are still unknown or only partly explored. In this talk I will present my latest results on the implications of photon interactions in photon BECs. In particular, I will investigate the effect of a thermo-optic non-linearity, leading to spatially non-local and delayed interactions. Starting from the steady state behavior, I will explore the spectrum of elementary excitations as a small perturbation. Moreover, I will discuss the resulting effective photon dispersion, manifesting various properties including possible superfluidity, as well as roton and maxon modes. The implications of physical parameters as absorption, number of photons in the condensate, and cavity trap on the dispersion will be discussed. The results of this study shed new light on the implication of interactions in photonic many-body systems. Hadiseh Alaeian acknowledges the generous support from Alexander von Humboldt Foundation.

Vortex creation during magnetic trap manipulations of spinor Bose-Einstein condensates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Itin, A. P.; Space Research Institute, RAS, Moscow; Morishita, T.

2006-06-15

We investigate several mechanisms of vortex creation during splitting of a spinor Bose-Einstein condensate (BEC) in a magnetic double-well trap controlled by a pair of current carrying wires and bias magnetic fields. Our study is motivated by a recent MIT experiment on splitting BECs with a similar trap [Y. Shin et al., Phys. Rev. A 72, 021604 (2005)], where an unexpected fork-like structure appeared in the interference fringes indicating the presence of a singly quantized vortex in one of the interfering condensates. It is well known that in a spin-1 BEC in a quadrupole trap, a doubly quantized vortex ismore » topologically produced by a 'slow' reversal of bias magnetic field B{sub z}. Since in the experiment a doubly quantized vortex had never been seen, Shin et al. ruled out the topological mechanism and concentrated on the nonadiabatic mechanical mechanism for explanation of the vortex creation. We find, however, that in the magnetic trap considered both mechanisms are possible: singly quantized vortices can be formed in a spin-1 BEC topologically (for example, during the magnetic field switching-off process). We therefore provide a possible alternative explanation for the interference patterns observed in the experiment. We also present a numerical example of creation of singly quantized vortices due to 'fast' splitting; i.e., by a dynamical (nonadiabatic) mechanism.« less

Localized spatially nonlinear matter waves in atomic-molecular Bose-Einstein condensates with space-modulated nonlinearity

PubMed Central

Yao, Yu-Qin; Li, Ji; Han, Wei; Wang, Deng-Shan; Liu, Wu-Ming

2016-01-01

The intrinsic nonlinearity is the most remarkable characteristic of the Bose-Einstein condensates (BECs) systems. Many studies have been done on atomic BECs with time- and space- modulated nonlinearities, while there is few work considering the atomic-molecular BECs with space-modulated nonlinearities. Here, we obtain two kinds of Jacobi elliptic solutions and a family of rational solutions of the atomic-molecular BECs with trapping potential and space-modulated nonlinearity and consider the effect of three-body interaction on the localized matter wave solutions. The topological properties of the localized nonlinear matter wave for no coupling are analysed: the parity of nonlinear matter wave functions depends only on the principal quantum number n, and the numbers of the density packets for each quantum state depend on both the principal quantum number n and the secondary quantum number l. When the coupling is not zero, the localized nonlinear matter waves given by the rational function, their topological properties are independent of the principal quantum number n, only depend on the secondary quantum number l. The Raman detuning and the chemical potential can change the number and the shape of the density packets. The stability of the Jacobi elliptic solutions depends on the principal quantum number n, while the stability of the rational solutions depends on the chemical potential and Raman detuning. PMID:27403634

1989-90 Statewide Computer Survey Report.

ERIC Educational Resources Information Center

South Carolina State Dept. of Education, Columbia. Office of Instructional Technology.

This report presents the findings from South Carolina's seventh statewide computer survey. The survey solicited information on computer equipment and software, and dealt with such issues as the instructional and administrative uses of computers and the availability and use of Software Evaluation Exchange Dissemination (SEED) software reviews and a…

Non-developmental item computer systems and the malicious software threat

NASA Technical Reports Server (NTRS)

Bown, Rodney L.

1991-01-01

The following subject areas are covered: a DOD development system - the Army Secure Operating System; non-development commercial computer systems; security, integrity, and assurance of service (SI and A); post delivery SI and A and malicious software; computer system unique attributes; positive feedback to commercial computer systems vendors; and NDI (Non-Development Item) computers and software safety.

48 CFR 252.227-7028 - Technical data or computer software previously delivered to the government.

Code of Federal Regulations, 2010 CFR

2010-10-01

... software previously delivered to the government. 252.227-7028 Section 252.227-7028 Federal Acquisition... computer software previously delivered to the government. As prescribed in 227.7103-6(d), 227.7104(f)(2), or 227.7203-6(e), use the following provision: Technical Data or Computer Software Previously...

48 CFR 252.227-7028 - Technical data or computer software previously delivered to the government.

Code of Federal Regulations, 2012 CFR

2012-10-01

... software previously delivered to the government. 252.227-7028 Section 252.227-7028 Federal Acquisition... computer software previously delivered to the government. As prescribed in 227.7103-6(d), 227.7104(f)(2), or 227.7203-6(e), use the following provision: Technical Data or Computer Software Previously...

48 CFR 252.227-7028 - Technical data or computer software previously delivered to the government.

Code of Federal Regulations, 2014 CFR

2014-10-01

... software previously delivered to the government. 252.227-7028 Section 252.227-7028 Federal Acquisition... computer software previously delivered to the government. As prescribed in 227.7103-6(d), 227.7104(f)(2), or 227.7203-6(e), use the following provision: Technical Data or Computer Software Previously...

48 CFR 252.227-7028 - Technical data or computer software previously delivered to the government.

Code of Federal Regulations, 2013 CFR

2013-10-01

... software previously delivered to the government. 252.227-7028 Section 252.227-7028 Federal Acquisition... computer software previously delivered to the government. As prescribed in 227.7103-6(d), 227.7104(f)(2), or 227.7203-6(e), use the following provision: Technical Data or Computer Software Previously...

48 CFR 252.227-7028 - Technical data or computer software previously delivered to the government.

Code of Federal Regulations, 2011 CFR

2011-10-01

... software previously delivered to the government. 252.227-7028 Section 252.227-7028 Federal Acquisition... computer software previously delivered to the government. As prescribed in 227.7103-6(d), 227.7104(f)(2), or 227.7203-6(e), use the following provision: Technical Data or Computer Software Previously...

Computer Software: Copyright and Licensing Considerations for Schools and Libraries. ERIC Digest.

ERIC Educational Resources Information Center

Reed, Mary Hutchings

This digest notes that the terms and conditions of computer software package license agreements control the use of software in schools and libraries, and examines the implications of computer software license agreements for classroom use and for library lending policies. Guidelines are provided for interpreting the Copyright Act, and insuring the…

Tools for Administration of a UNIX-Based Network

NASA Technical Reports Server (NTRS)

LeClaire, Stephen; Farrar, Edward

2004-01-01

Several computer programs have been developed to enable efficient administration of a large, heterogeneous, UNIX-based computing and communication network that includes a variety of computers connected to a variety of subnetworks. One program provides secure software tools for administrators to create, modify, lock, and delete accounts of specific users. This program also provides tools for users to change their UNIX passwords and log-in shells. These tools check for errors. Another program comprises a client and a server component that, together, provide a secure mechanism to create, modify, and query quota levels on a network file system (NFS) mounted by use of the VERITAS File SystemJ software. The client software resides on an internal secure computer with a secure Web interface; one can gain access to the client software from any authorized computer capable of running web-browser software. The server software resides on a UNIX computer configured with the VERITAS software system. Directories where VERITAS quotas are applied are NFS-mounted. Another program is a Web-based, client/server Internet Protocol (IP) address tool that facilitates maintenance lookup of information about IP addresses for a network of computers.

77 FR 50724 - Developing Software Life Cycle Processes for Digital Computer Software Used in Safety Systems of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-22

... NUCLEAR REGULATORY COMMISSION [NRC-2012-0195] Developing Software Life Cycle Processes for Digital... Software Life Cycle Processes for Digital Computer Software used in Safety Systems of Nuclear Power Plants... clarifications, the enhanced consensus practices for developing software life-cycle processes for digital...

Software platform virtualization in chemistry research and university teaching

PubMed Central

2009-01-01

Background Modern chemistry laboratories operate with a wide range of software applications under different operating systems, such as Windows, LINUX or Mac OS X. Instead of installing software on different computers it is possible to install those applications on a single computer using Virtual Machine software. Software platform virtualization allows a single guest operating system to execute multiple other operating systems on the same computer. We apply and discuss the use of virtual machines in chemistry research and teaching laboratories. Results Virtual machines are commonly used for cheminformatics software development and testing. Benchmarking multiple chemistry software packages we have confirmed that the computational speed penalty for using virtual machines is low and around 5% to 10%. Software virtualization in a teaching environment allows faster deployment and easy use of commercial and open source software in hands-on computer teaching labs. Conclusion Software virtualization in chemistry, mass spectrometry and cheminformatics is needed for software testing and development of software for different operating systems. In order to obtain maximum performance the virtualization software should be multi-core enabled and allow the use of multiprocessor configurations in the virtual machine environment. Server consolidation, by running multiple tasks and operating systems on a single physical machine, can lead to lower maintenance and hardware costs especially in small research labs. The use of virtual machines can prevent software virus infections and security breaches when used as a sandbox system for internet access and software testing. Complex software setups can be created with virtual machines and are easily deployed later to multiple computers for hands-on teaching classes. We discuss the popularity of bioinformatics compared to cheminformatics as well as the missing cheminformatics education at universities worldwide. PMID:20150997

Software platform virtualization in chemistry research and university teaching.

PubMed

Kind, Tobias; Leamy, Tim; Leary, Julie A; Fiehn, Oliver

2009-11-16

Modern chemistry laboratories operate with a wide range of software applications under different operating systems, such as Windows, LINUX or Mac OS X. Instead of installing software on different computers it is possible to install those applications on a single computer using Virtual Machine software. Software platform virtualization allows a single guest operating system to execute multiple other operating systems on the same computer. We apply and discuss the use of virtual machines in chemistry research and teaching laboratories. Virtual machines are commonly used for cheminformatics software development and testing. Benchmarking multiple chemistry software packages we have confirmed that the computational speed penalty for using virtual machines is low and around 5% to 10%. Software virtualization in a teaching environment allows faster deployment and easy use of commercial and open source software in hands-on computer teaching labs. Software virtualization in chemistry, mass spectrometry and cheminformatics is needed for software testing and development of software for different operating systems. In order to obtain maximum performance the virtualization software should be multi-core enabled and allow the use of multiprocessor configurations in the virtual machine environment. Server consolidation, by running multiple tasks and operating systems on a single physical machine, can lead to lower maintenance and hardware costs especially in small research labs. The use of virtual machines can prevent software virus infections and security breaches when used as a sandbox system for internet access and software testing. Complex software setups can be created with virtual machines and are easily deployed later to multiple computers for hands-on teaching classes. We discuss the popularity of bioinformatics compared to cheminformatics as well as the missing cheminformatics education at universities worldwide.

Whole earth modeling: developing and disseminating scientific software for computational geophysics.

NASA Astrophysics Data System (ADS)

Kellogg, L. H.

2016-12-01

Historically, a great deal of specialized scientific software for modeling and data analysis has been developed by individual researchers or small groups of scientists working on their own specific research problems. As the magnitude of available data and computer power has increased, so has the complexity of scientific problems addressed by computational methods, creating both a need to sustain existing scientific software, and expand its development to take advantage of new algorithms, new software approaches, and new computational hardware. To that end, communities like the Computational Infrastructure for Geodynamics (CIG) have been established to support the use of best practices in scientific computing for solid earth geophysics research and teaching. Working as a scientific community enables computational geophysicists to take advantage of technological developments, improve the accuracy and performance of software, build on prior software development, and collaborate more readily. The CIG community, and others, have adopted an open-source development model, in which code is developed and disseminated by the community in an open fashion, using version control and software repositories like Git. One emerging issue is how to adequately identify and credit the intellectual contributions involved in creating open source scientific software. The traditional method of disseminating scientific ideas, peer reviewed publication, was not designed for review or crediting scientific software, although emerging publication strategies such software journals are attempting to address the need. We are piloting an integrated approach in which authors are identified and credited as scientific software is developed and run. Successful software citation requires integration with the scholarly publication and indexing mechanisms as well, to assign credit, ensure discoverability, and provide provenance for software.

48 CFR 252.204-7014 - Limitations on the Use or Disclosure of Information by Litigation Support Contractors.

Code of Federal Regulations, 2014 CFR

2014-10-01

.... Computer software does not include computer data bases or computer software documentation. Litigation... includes technical data and computer software, but does not include information that is lawfully, publicly available without restriction. Technical data means recorded information, regardless of the form or method...

Analysis of Software Systems for Specialized Computers,

DTIC Science & Technology

computer) with given computer hardware and software . The object of study is the software system of a computer, designed for solving a fixed complex of...purpose of the analysis is to find parameters that characterize the system and its elements during operation, i.e., when servicing the given requirement flow. (Author)

A Home Computer Primer.

ERIC Educational Resources Information Center

Stone, Antonia

1982-01-01

Provides general information on currently available microcomputers, computer programs (software), hardware requirements, software sources, costs, computer games, and programing. Includes a list of popular microcomputers, providing price category, model, list price, software (cassette, tape, disk), monitor specifications, amount of random access…

ClimEx - Climate change and hydrological extreme events - risks and perspectives for water management in Bavaria and Québec

NASA Astrophysics Data System (ADS)

Ludwig, Ralf; Baese, Frank; Braun, Marco; Brietzke, Gilbert; Brissette, Francois; Frigon, Anne; Giguère, Michel; Komischke, Holger; Kranzlmueller, Dieter; Leduc, Martin; Martel, Jean-Luc; Ricard, Simon; Schmid, Josef; von Trentini, Fabian; Turcotte, Richard; Weismueller, Jens; Willkofer, Florian; Wood, Raul

2017-04-01

The recent accumulation of extreme hydrological events in Bavaria and Québec has stimulated scientific and also societal interest. In addition to the challenges of an improved prediction of such situations and the implications for the associated risk management, there is, as yet, no confirmed knowledge whether and how climate change contributes to the magnitude and frequency of hydrological extreme events and how regional water management could adapt to the corresponding risks. The ClimEx project (2015-2019) investigates the effects of climate change on the meteorological and hydrological extreme events and their implications for water management in Bavaria and Québec. High Performance Computing is employed to enable the complex simulations in a hydro-climatological model processing chain, resulting in a unique high-resolution and transient (1950-2100) dataset of climatological and meteorological forcing and hydrological response: (1) The climate module has developed a large ensemble of high resolution data (12km) of the CRCM5 RCM for Central Europe and North-Eastern North America, downscaled from 50 members of the CanESM2 GCM. The dataset is complemented by all available data from the Euro-CORDEX project to account for the assessment of both natural climate variability and climate change. The large ensemble with several thousand model years provides the potential to catch rare extreme events and thus improves the process understanding of extreme events with return periods of 1000+ years. (2) The hydrology module comprises process-based and spatially explicit model setups (e.g. WaSiM) for all major catchments in Bavaria and Southern Québec in high temporal (3h) and spatial (500m) resolution. The simulations form the basis for in depth analysis of hydrological extreme events based on the inputs from the large climate model dataset. The specific data situation enables to establish a new method for 'virtual perfect prediction', which assesses climate change impacts on flood risk and water resources management by identifying patterns in the data which reveal preferential triggers of hydrological extreme events. The presentation will highlight first results from the analysis of the large scale ClimEx model ensemble, showing the current and future ratio of natural variability and climate change impacts on meteorological extreme events. Selected data from the ensemble is used to drive a hydrological model experiment to illustrate the capacity to better determine the recurrence periods of hydrological extreme events under conditions of climate change. [The authors acknowledge funding for the project from the Bavarian State Ministry for the Environment and Consumer Protection].

The Use of Computer Software to Teach High Technology Skills to Vocational Students.

ERIC Educational Resources Information Center

Farmer, Edgar I.

A study examined the type of computer software that is best suited to teach high technology skills to vocational students. During the study, 50 manufacturers of computer software and hardware were sent questionnaires designed to gather data concerning their recommendations in regard to: software to teach high technology skills to vocational…

34 CFR 464.42 - What limit applies to purchasing computer hardware and software?

Code of Federal Regulations, 2013 CFR

2013-07-01

... software? 464.42 Section 464.42 Education Regulations of the Offices of the Department of Education... computer hardware and software? Not more than ten percent of funds received under any grant under this part may be used to purchase computer hardware or software. (Authority: 20 U.S.C. 1208aa(f)) ...

34 CFR 464.42 - What limit applies to purchasing computer hardware and software?

Code of Federal Regulations, 2012 CFR

2012-07-01

... software? 464.42 Section 464.42 Education Regulations of the Offices of the Department of Education... computer hardware and software? Not more than ten percent of funds received under any grant under this part may be used to purchase computer hardware or software. (Authority: 20 U.S.C. 1208aa(f)) ...

34 CFR 464.42 - What limit applies to purchasing computer hardware and software?

Code of Federal Regulations, 2011 CFR

2011-07-01

... software? 464.42 Section 464.42 Education Regulations of the Offices of the Department of Education... computer hardware and software? Not more than ten percent of funds received under any grant under this part may be used to purchase computer hardware or software. (Authority: 20 U.S.C. 1208aa(f)) ...

34 CFR 464.42 - What limit applies to purchasing computer hardware and software?

Code of Federal Regulations, 2010 CFR

2010-07-01

... software? 464.42 Section 464.42 Education Regulations of the Offices of the Department of Education... computer hardware and software? Not more than ten percent of funds received under any grant under this part may be used to purchase computer hardware or software. (Authority: 20 U.S.C. 1208aa(f)) ...

34 CFR 464.42 - What limit applies to purchasing computer hardware and software?

Code of Federal Regulations, 2014 CFR

2014-07-01

... software? 464.42 Section 464.42 Education Regulations of the Offices of the Department of Education... computer hardware and software? Not more than ten percent of funds received under any grant under this part may be used to purchase computer hardware or software. (Authority: 20 U.S.C. 1208aa(f)) ...

Copyright Protection for Computer Software: Is There a Need for More Protection?

ERIC Educational Resources Information Center

Ku, Linlin

Because the computer industry's expansion has been much faster than has the development of laws protecting computer software and since the practice of software piracy seems to be alive and well, the issue of whether existing laws can provide effective protection for software needs further discussion. Three bodies of law have been used to protect…

Development of simulation computer complex specification

NASA Technical Reports Server (NTRS)

1973-01-01

The Training Simulation Computer Complex Study was one of three studies contracted in support of preparations for procurement of a shuttle mission simulator for shuttle crew training. The subject study was concerned with definition of the software loads to be imposed on the computer complex to be associated with the shuttle mission simulator and the development of procurement specifications based on the resulting computer requirements. These procurement specifications cover the computer hardware and system software as well as the data conversion equipment required to interface the computer to the simulator hardware. The development of the necessary hardware and software specifications required the execution of a number of related tasks which included, (1) simulation software sizing, (2) computer requirements definition, (3) data conversion equipment requirements definition, (4) system software requirements definition, (5) a simulation management plan, (6) a background survey, and (7) preparation of the specifications.

Software Safety Risk in Legacy Safety-Critical Computer Systems

NASA Technical Reports Server (NTRS)

Hill, Janice; Baggs, Rhoda

2007-01-01

Safety-critical computer systems must be engineered to meet system and software safety requirements. For legacy safety-critical computer systems, software safety requirements may not have been formally specified during development. When process-oriented software safety requirements are levied on a legacy system after the fact, where software development artifacts don't exist or are incomplete, the question becomes 'how can this be done?' The risks associated with only meeting certain software safety requirements in a legacy safety-critical computer system must be addressed should such systems be selected as candidates for reuse. This paper proposes a method for ascertaining formally, a software safety risk assessment, that provides measurements for software safety for legacy systems which may or may not have a suite of software engineering documentation that is now normally required. It relies upon the NASA Software Safety Standard, risk assessment methods based upon the Taxonomy-Based Questionnaire, and the application of reverse engineering CASE tools to produce original design documents for legacy systems.

48 CFR 227.7201 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7201 Definitions. (a) As used in this subpart, unless... subpart are defined in the clause at 252.227-7014, Rights in Noncommercial Computer Software and...

48 CFR 227.7201 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7201 Definitions. (a) As used in this subpart, unless... subpart are defined in the clause at 252.227-7014, Rights in Noncommercial Computer Software and...

48 CFR 227.7201 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7201 Definitions. (a) As used in this subpart, unless... subpart are defined in the clause at 252.227-7014, Rights in Noncommercial Computer Software and...

48 CFR 227.7201 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7201 Definitions. (a) As used in this subpart, unless... subpart are defined in the clause at 252.227-7014, Rights in Noncommercial Computer Software and...

48 CFR 227.7201 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7201 Definitions. (a) As used in this subpart, unless... subpart are defined in the clause at 252.227-7014, Rights in Noncommercial Computer Software and...

29 CFR 541.401 - Computer manufacture and repair.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., the use of computers and computer software programs (e.g., engineers, drafters and others skilled in computer-aided design software), but who are not primarily engaged in computer systems analysis and...

29 CFR 541.401 - Computer manufacture and repair.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., the use of computers and computer software programs (e.g., engineers, drafters and others skilled in computer-aided design software), but who are not primarily engaged in computer systems analysis and...

29 CFR 541.401 - Computer manufacture and repair.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., the use of computers and computer software programs (e.g., engineers, drafters and others skilled in computer-aided design software), but who are not primarily engaged in computer systems analysis and...

29 CFR 541.401 - Computer manufacture and repair.

Code of Federal Regulations, 2010 CFR

2010-07-01

..., the use of computers and computer software programs (e.g., engineers, drafters and others skilled in computer-aided design software), but who are not primarily engaged in computer systems analysis and...

Optomechanically induced transparency with Bose–Einstein condensate in double-cavity optomechanical system

NASA Astrophysics Data System (ADS)

Liu, Li-Wei; Gengzang, Duo-Jie; An, Xiu-Jia; Wang, Pei-Yu

2018-03-01

We propose a novel technique of generating multiple optomechanically induced transparency (OMIT) of a weak probe field in hybrid optomechanical system. This system consists of a cigar-shaped Bose–Einstein condensate (BEC), trapped inside each high finesse Fabry-Pérot cavity. In the resolved sideband regime, the analytic solutions of the absorption and the dispersion spectrum are given. The tunneling strength of the two resonators and the coupling parameters of the each BEC in combination with the cavity field have the appearance of three distinct OMIT windows in the absorption spectrum. Furthermore, whether there is BEC in each cavity is a key factor in the number of OMIT windows determination. The technique presented may have potential applications in quantum engineering and quantum information networks. Project supported by the National Natural Science Foundation of China (Grant Nos. 11564034, 11105062, and 21663026) and the Scientific Research Funds of College of Electrical Engineering, Northwest University, China (Grant No. xbmuyjrc201115).

Bulk-edge correspondence in topological transport and pumping

NASA Astrophysics Data System (ADS)

Imura, Ken-Ichiro; Yoshimura, Yukinori; Fukui, Takahiro; Hatsugai, Yasuhiro

2018-03-01

The bulk-edge correspondence (BEC) refers to a one-to-one relation between the bulk and edge properties ubiquitous in topologically nontrivial systems. Depending on the setup, BEC manifests in different forms and govern the spectral and transport properties of topological insulators and semimetals. Although the topological pump is theoretically old, BEC in the pump has been established just recently [1] motivated by the state-of-the-art experiments using cold atoms [2, 3]. The center of mass (CM) of a system with boundaries shows a sequence of quantized jumps in the adiabatic limit associated with the edge states. Despite that the bulk is adiabatic, the edge is inevitably non-adiabatic in the experimental setup or in any numerical simulations. Still the pumped charge is quantized and carried by the bulk. Its quantization is guaranteed by a compensation between the bulk and edges. We show that in the presence of disorder the pumped charge continues to be quantized despite the appearance of non-quantized jumps.

Localized nonlinear waves and dynamical stability in spinor Bose–Einstein condensates with time–space modulation

NASA Astrophysics Data System (ADS)

Yao, Yu-Qin; Han, Wei; Li, Ji; Liu, Wu-Ming

2018-05-01

Nonlinearity is one of the most remarkable characteristics of Bose–Einstein condensates (BECs). Much work has been done on one- and two-component BECs with time- or space-modulated nonlinearities, while there is little work on spinor BECs with space–time-modulated nonlinearities. In the present paper we investigate localized nonlinear waves and dynamical stability in spinor Bose–Einstein condensates with nonlinearities dependent on time and space. We solve the three coupled Gross–Pitaevskii equations by similarity transformation and obtain two families of exact matter wave solutions in terms of Jacobi elliptic functions and the Mathieu equation. The localized states of the spinor matter wave describe the dynamics of vector breathing solitons, moving breathing solitons, quasi-breathing solitons and resonant solitons. The results show that one-order vector breathing solitons, quasi-breathing solitons, resonant solitons and the moving breathing solitons ψ ±1 are all stable, but the moving breathing soliton ψ 0 is unstable. We also present the experimental parameters to realize these phenomena in future experiments.

Elements of Dynamics of a One-Dimensional Trapped Bose-Einstein Condensate Excited by a Time-Dependent Dimple: A Lagrangian Variational Approach

NASA Astrophysics Data System (ADS)

Sakhel, Asaad R.; Sakhel, Roger R.

2018-02-01

We examine the dynamics of a one-dimensional harmonically trapped Bose-Einstein condensate (BEC), induced by the addition of a dimple trap whose depth oscillates with time. For this purpose, the Lagrangian variational method (LVM) is applied to provide the required analytical equations. The goal is to provide an analytical explanation for the quasiperiodic oscillations of the BEC size at resonance, that is additional to the one given by Adhikari (J Phys B At Mol Opt Phys 36:1109, 2003). It is shown that LVM is able to reproduce instabilities in the dynamics along the same lines outlined by Lellouch et al. (Phys Rev X 7:021015, 2017). Moreover, it is found that at resonance the energy dynamics display ordered oscillations, whereas at off-resonance they tend to be chaotic. Further, by using the Poincare-Lindstedt method to solve the LVM equation of motion, the resulting solution is able to reproduce the quasiperiodic oscillations of the BEC.

Gap Solitons of Superfluid Fermi Gas in FS Optical Lattices

NASA Astrophysics Data System (ADS)

Chen, Yan; Zhang, Ke-Zhi; He, Yong-Lin; Liu, Zhen-Lai; Zhu, Liao

2018-01-01

By employing the mean-field theory and hydrodynamic scheme, we study the gap solitons of superfluid Fermi gas in Fourier-Synthesized(FS) optical lattices. By means of numerical methods and variational approximation, the atomic interaction, the chemical potential, the potential depth of the lattice and relative phase of the Fermi system are derived along the Bose-Enstein condensation(BEC)side to the Bardeen-Cooper-Schrieffer (BCS)side. It means that the condition exciting gap solitons is obtained. Moreover, we analyze the fundamental gap soltions of the superfluid Fermi gas. It is found that the relative phase α impacts greatly on the properties of fundamental gap solitons for superfluid Fermi gas. Especially, the nonlinearity interaction term g decreases with α. Add, due to Fermi pressure, curvature changes of g in the BEC limit( γ = 1, here, γ is a function of an interaction parameter) is larger than that at unitary ( γ = 2/3). Spatial distribution of gap solitons exhibit very obvious different when the system transit from the BEC side to BCS side.

Architecture independent environment for developing engineering software on MIMD computers

NASA Technical Reports Server (NTRS)

Valimohamed, Karim A.; Lopez, L. A.

1990-01-01

Engineers are constantly faced with solving problems of increasing complexity and detail. Multiple Instruction stream Multiple Data stream (MIMD) computers have been developed to overcome the performance limitations of serial computers. The hardware architectures of MIMD computers vary considerably and are much more sophisticated than serial computers. Developing large scale software for a variety of MIMD computers is difficult and expensive. There is a need to provide tools that facilitate programming these machines. First, the issues that must be considered to develop those tools are examined. The two main areas of concern were architecture independence and data management. Architecture independent software facilitates software portability and improves the longevity and utility of the software product. It provides some form of insurance for the investment of time and effort that goes into developing the software. The management of data is a crucial aspect of solving large engineering problems. It must be considered in light of the new hardware organizations that are available. Second, the functional design and implementation of a software environment that facilitates developing architecture independent software for large engineering applications are described. The topics of discussion include: a description of the model that supports the development of architecture independent software; identifying and exploiting concurrency within the application program; data coherence; engineering data base and memory management.

Small-College Software Survey.

ERIC Educational Resources Information Center

Birch, Anthony D.

1986-01-01

Computers have a great number of potential uses at the small college. A survey of the role of software in the effective use of computers is described. Hardware characteristics, spreadsheets, purchasing or developing software, and software information are discussed. (Author/MLW)

Software engineering methodologies and tools

NASA Technical Reports Server (NTRS)

Wilcox, Lawrence M.

1993-01-01

Over the years many engineering disciplines have developed, including chemical, electronic, etc. Common to all engineering disciplines is the use of rigor, models, metrics, and predefined methodologies. Recently, a new engineering discipline has appeared on the scene, called software engineering. For over thirty years computer software has been developed and the track record has not been good. Software development projects often miss schedules, are over budget, do not give the user what is wanted, and produce defects. One estimate is there are one to three defects per 1000 lines of deployed code. More and more systems are requiring larger and more complex software for support. As this requirement grows, the software development problems grow exponentially. It is believed that software quality can be improved by applying engineering principles. Another compelling reason to bring the engineering disciplines to software development is productivity. It has been estimated that productivity of producing software has only increased one to two percent a year in the last thirty years. Ironically, the computer and its software have contributed significantly to the industry-wide productivity, but computer professionals have done a poor job of using the computer to do their job. Engineering disciplines and methodologies are now emerging supported by software tools that address the problems of software development. This paper addresses some of the current software engineering methodologies as a backdrop for the general evaluation of computer assisted software engineering (CASE) tools from actual installation of and experimentation with some specific tools.

Ground Software Maintenance Facility (GSMF) system manual

NASA Technical Reports Server (NTRS)

Derrig, D.; Griffith, G.

1986-01-01

The Ground Software Maintenance Facility (GSMF) is designed to support development and maintenance of spacelab ground support software. THE GSMF consists of a Perkin Elmer 3250 (Host computer) and a MITRA 125s (ATE computer), with appropriate interface devices and software to simulate the Electrical Ground Support Equipment (EGSE). This document is presented in three sections: (1) GSMF Overview; (2) Software Structure; and (3) Fault Isolation Capability. The overview contains information on hardware and software organization along with their corresponding block diagrams. The Software Structure section describes the modes of software structure including source files, link information, and database files. The Fault Isolation section describes the capabilities of the Ground Computer Interface Device, Perkin Elmer host, and MITRA ATE.

77 FR 32996 - Certain Handheld Electronic Computing Devices, Related Software, and Components Thereof...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-04

... INTERNATIONAL TRADE COMMISSION [Investigation No. 337-TA-769] Certain Handheld Electronic Computing Devices, Related Software, and Components Thereof; Termination of the Investigation Based on... electronic computing devices, related software, and components thereof by reason of infringement of certain...

48 CFR 227.7207 - Contractor data repositories.

Code of Federal Regulations, 2010 CFR

2010-10-01

... repositories. 227.7207 Section 227.7207 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... Computer Software and Computer Software Documentation 227.7207 Contractor data repositories. Follow 227.7108 when it is in the Government's interests to have a data repository include computer software or to...

Cloud Computing: A Free Technology Option to Promote Collaborative Learning

ERIC Educational Resources Information Center

Siegle, Del

2010-01-01

In a time of budget cuts and limited funding, purchasing and installing the latest software on classroom computers can be prohibitive for schools. Many educators are unaware that a variety of free software options exist, and some of them do not actually require installing software on the user's computer. One such option is cloud computing. This…

From Policy to Practice: Implementation of Treatment for Substance Misuse in Québec Primary Healthcare Clinics

PubMed Central

Maynard, Serge; Campbell, Emily; Boodhoo, Katie; Gauthier, Gail; Xenocostas, Spyridoula; Charney, Dara A.

2015-01-01

Background and Objectives: In 2007, the Québec Ministry of Health issued a policy document that specifically mandated the development of addiction treatment services including screening, brief interventions and referral (SBIR) to be delivered by primary healthcare clinics throughout Québec. The current study examined the level of implementation of SBIR one year following the end of the mandate (2007–2012). Approach: Semi-structured interviews were conducted with 45 participants from 21 primary health and social service centres throughout the province. Qualitative analysis was used to evaluate the level of success each centre had in implementing SBIR and to identify organizational measures that contributed to successful implementation. Results: The results show that Québec primary health and social service centres had limited success in their efforts to integrate SBIR into their services. A comparative analysis of the centres, categorized according to their level of implementation, revealed the presence of significant organizational- and staff-level factors, including the creation of formal action plans that were conducive to the successful implementation of SBIR in primary care. Conclusion: The findings highlight the importance of offering support and guidance, as well as a menu of specific practices that are likely to assist primary health and social services centres to implement SBIR. At the organizational level, the adoption of local action plans and formal service trajectories offers a framework that allows for horizontal and vertical integration of new practices. PMID:26742118

From Policy to Practice: Implementation of Treatment for Substance Misuse in Québec Primary Healthcare Clinics.

PubMed

Maynard, Serge; Campbell, Emily; Boodhoo, Katie; Gauthier, Gail; Xenocostas, Spyridoula; Charney, Dara A; Gill, Kathryn

2015-11-01

In 2007, the Québec Ministry of Health issued a policy document that specifically mandated the development of addiction treatment services including screening, brief interventions and referral (SBIR) to be delivered by primary healthcare clinics throughout Québec. The current study examined the level of implementation of SBIR one year following the end of the mandate (2007-2012). Semi-structured interviews were conducted with 45 participants from 21 primary health and social service centres throughout the province. Qualitative analysis was used to evaluate the level of success each centre had in implementing SBIR and to identify organizational measures that contributed to successful implementation. The results show that Québec primary health and social service centres had limited success in their efforts to integrate SBIR into their services. A comparative analysis of the centres, categorized according to their level of implementation, revealed the presence of significant organizational- and staff-level factors, including the creation of formal action plans that were conducive to the successful implementation of SBIR in primary care. The findings highlight the importance of offering support and guidance, as well as a menu of specific practices that are likely to assist primary health and social services centres to implement SBIR. At the organizational level, the adoption of local action plans and formal service trajectories offers a framework that allows for horizontal and vertical integration of new practices. Copyright © 2015 Longwoods Publishing.

Relaxation dynamics of a driven two-level system coupled to a Bose-Einstein condensate: application to quantum dot-dipolar exciton gas hybrid systems.

PubMed

Kovalev, Vadim M; Tse, Wang-Kong

2017-11-22

We develop a microscopic theory for the relaxation dynamics of an optically pumped two-level system (TLS) coupled to a bath of weakly interacting Bose gas. Using Keldysh formalism and diagrammatic perturbation theory, expressions for the relaxation times of the TLS Rabi oscillations are derived when the boson bath is in the normal state and the Bose-Einstein condensate (BEC) state. We apply our general theory to consider an irradiated quantum dot coupled with a boson bath consisting of a two-dimensional dipolar exciton gas. When the bath is in the BEC regime, relaxation of the Rabi oscillations is due to both condensate and non-condensate fractions of the bath bosons for weak TLS-light coupling and pre dominantly due to the non-condensate fraction for strong TLS-light coupling. Our theory also shows that a phase transition of the bath from the normal to the BEC state strongly influences the relaxation rate of the TLS Rabi oscillations. The TLS relaxation rate is approximately independent of the pump field frequency and monotonically dependent on the field strength when the bath is in the low-temperature regime of the normal phase. Phase transition of the dipolar exciton gas leads to a non-monotonic dependence of the TLS relaxation rate on both the pump field frequency and field strength, providing a characteristic signature for the detection of BEC phase transition of the coupled dipolar exciton gas.

A comparison of dehydroepiandrosterone and 7-keto dehydroepiandrosterone with other drugs that modulate ethanol intake in rats responding under a multiple schedule

PubMed Central

Amato, Russell J.; Hulin, Mary W.; Winsauer, Peter J.

2012-01-01

Dehydroepiandrosterone (DHEA), 7-keto DHEA, and several comparison drugs (ethanol, chlordiazepoxide, rauwolscine, and RO15-4513) were administered to male rats responding under a multiple schedule of food and ethanol presentation to determine their selectively for decreasing ethanol-maintained responding. DHEA and 7-keto DHEA significantly decreased both ethanol- and food-maintained responding, compared to control, while also decreasing blood ethanol concentration (BEC). Acute ethanol administration also decreased responding for both food and ethanol; however, ethanol-maintained responding was more potently decreased than food-maintained responding. BEC remained relatively stable after increasing ethanol doses. Among the other drugs tested, RO15-4513 was the most selective for decreasing ethanol-maintained responding compared to food-maintained responding, and it decreased BECs as ethanol-maintained responding decreased. The largest dose of rauwolscine significantly decreased responding for food, while not affecting ethanol-maintained responding compared to control. Low to intermediate doses of rauwolscine produced small, non-significant increases in ethanol-maintained responding and BECs. Chlordiazepoxide produced significant decreases in food-maintained responding and the dose of ethanol presented, but only at the highest dose tested. Although DHEA and 7-keto DHEA did not decrease ethanol-maintained responding as selectively as ethanol or RO15-4513 under the multiple schedule, these neurosteroids may be valuable pharmacological tools in the development of new treatments for alcohol abuse and dependence. PMID:22473025

Topological vortex formation in a Bose-Einstein condensate under gravitational field

NASA Astrophysics Data System (ADS)

Kawaguchi, Yuki; Nakahara, Mikio; Ohmi, Tetsuo

2004-10-01

Topological phase imprinting is a unique technique for vortex formation in a Bose-Einstein condensate (BEC) of an alkali-metal gas, in that it does not involve rotation: the BEC is trapped in a quadrupole field with a uniform bias field which is reversed adiabatically leading to vortex formation at the center of the magnetic trap. The scenario has been experimentally verified by Leanhardt employing Na23 atoms. Recently similar experiments have been conducted by Hirotani in which a BEC of Rb87 atoms was used. In the latter experiments the authors found that fine-tuning of the field reverse time Trev is required to achieve stable vortex formation. Otherwise, they often observed vortex fragmentation or a condensate without a vortex. It is shown in this paper that this behavior can be attributed to the heavy mass of the Rb atom. The confining potential, which depends on the eigenvalue mB of the hyperfine spin F along the magnetic field, is now shifted by the gravitational field perpendicular to the vortex line. Then the positions of two weak-field-seeking states with mB=1 and 2 deviate from each other. This effect is more prominent for BECs with a heavy atomic mass, for which the deviation is greater and, moreover, the Thomas-Fermi radius is smaller. We found, by solving the Gross-Pitaevskii equation numerically, that two condensates interact in a very complicated way leading to fragmentation of vortices, unless Trev is properly tuned.

Time-of-flight expansion of binary Bose–Einstein condensates at finite temperature

NASA Astrophysics Data System (ADS)

Lee, K. L.; Jørgensen, N. B.; Wacker, L. J.; Skou, M. G.; Skalmstang, K. T.; Arlt, J. J.; Proukakis, N. P.

2018-05-01

Ultracold quantum gases provide a unique setting for studying and understanding the properties of interacting quantum systems. Here, we investigate a multi-component system of 87Rb–39K Bose–Einstein condensates (BECs) with tunable interactions both theoretically and experimentally. Such multi-component systems can be characterized by their miscibility, where miscible components lead to a mixed ground state and immiscible components form a phase-separated state. Here we perform the first full simulation of the dynamical expansion of this system including both BECs and thermal clouds, which allows for a detailed comparison with experimental results. In particular we show that striking features emerge in time-of-flight (TOF) for BECs with strong interspecies repulsion, even for systems which were separated in situ by a large gravitational sag. An analysis of the centre of mass positions of the BECs after expansion yields qualitative agreement with the homogeneous criterion for phase-separation, but reveals no clear transition point between the mixed and the separated phases. Instead one can identify a transition region, for which the presence of a gravitational sag is found to be advantageous. Moreover, we analyse the situation where only one component is condensed and show that the density distribution of the thermal component also shows some distinct features. Our work sheds new light on the analysis of multi-component systems after TOF and will guide future experiments on the detection of miscibility in these systems.

78 FR 47015 - Software Requirement Specifications for Digital Computer Software Used in Safety Systems of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-02

... NUCLEAR REGULATORY COMMISSION [NRC-2012-0195] Software Requirement Specifications for Digital Computer Software Used in Safety Systems of Nuclear Power Plants AGENCY: Nuclear Regulatory Commission... issuing a revised regulatory guide (RG), revision 1 of RG 1.172, ``Software Requirement Specifications for...

Parallel computers - Estimate errors caused by imprecise data

NASA Technical Reports Server (NTRS)

Kreinovich, Vladik; Bernat, Andrew; Villa, Elsa; Mariscal, Yvonne

1991-01-01

A new approach to the problem of estimating errors caused by imprecise data is proposed in the context of software engineering. A software device is used to produce an ideal solution to the problem, when the computer is capable of computing errors of arbitrary programs. The software engineering aspect of this problem is to describe a device for computing the error estimates in software terms and then to provide precise numbers with error estimates to the user. The feasibility of the program capable of computing both some quantity and its error estimate in the range of possible measurement errors is demonstrated.

Open-Source Software in Computational Research: A Case Study

DOE PAGES

Syamlal, Madhava; O'Brien, Thomas J.; Benyahia, Sofiane; ...

2008-01-01

A case study of open-source (OS) development of the computational research software MFIX, used for multiphase computational fluid dynamics simulations, is presented here. The verification and validation steps required for constructing modern computational software and the advantages of OS development in those steps are discussed. The infrastructure used for enabling the OS development of MFIX is described. The impact of OS development on computational research and education in gas-solids flow, as well as the dissemination of information to other areas such as geophysical and volcanology research, is demonstrated. This study shows that the advantages of OS development were realized inmore » the case of MFIX: verification by many users, which enhances software quality; the use of software as a means for accumulating and exchanging information; the facilitation of peer review of the results of computational research.« less

Computer Software & Intellectual Property. Background Paper.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Office of Technology Assessment.

This background paper reviews copyright, patent, and trade secret protections as these issues are related to computer software. Topics discussed include current issues regarding legal protection for computer software including the necessity for defining intellectual property, determining what should or should not be protected, commerical piracy,…

Computer Software Reviews.

ERIC Educational Resources Information Center

Hawaii State Dept. of Education, Honolulu. Office of Instructional Services.

Intended to provide guidance in the selection of the best computer software available to support instruction and to make optimal use of schools' financial resources, this publication provides a listing of computer software programs that have been evaluated according to their currency, relevance, and value to Hawaii's educational programs. The…

High Energy Physics Forum for Computational Excellence: Working Group Reports (I. Applications Software II. Software Libraries and Tools III. Systems)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Habib, Salman; Roser, Robert

Computing plays an essential role in all aspects of high energy physics. As computational technology evolves rapidly in new directions, and data throughput and volume continue to follow a steep trend-line, it is important for the HEP community to develop an effective response to a series of expected challenges. In order to help shape the desired response, the HEP Forum for Computational Excellence (HEP-FCE) initiated a roadmap planning activity with two key overlapping drivers -- 1) software effectiveness, and 2) infrastructure and expertise advancement. The HEP-FCE formed three working groups, 1) Applications Software, 2) Software Libraries and Tools, and 3)more » Systems (including systems software), to provide an overview of the current status of HEP computing and to present findings and opportunities for the desired HEP computational roadmap. The final versions of the reports are combined in this document, and are presented along with introductory material.« less

High Energy Physics Forum for Computational Excellence: Working Group Reports (I. Applications Software II. Software Libraries and Tools III. Systems)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Habib, Salman; Roser, Robert; LeCompte, Tom

2015-10-29

Computing plays an essential role in all aspects of high energy physics. As computational technology evolves rapidly in new directions, and data throughput and volume continue to follow a steep trend-line, it is important for the HEP community to develop an effective response to a series of expected challenges. In order to help shape the desired response, the HEP Forum for Computational Excellence (HEP-FCE) initiated a roadmap planning activity with two key overlapping drivers -- 1) software effectiveness, and 2) infrastructure and expertise advancement. The HEP-FCE formed three working groups, 1) Applications Software, 2) Software Libraries and Tools, and 3)more » Systems (including systems software), to provide an overview of the current status of HEP computing and to present findings and opportunities for the desired HEP computational roadmap. The final versions of the reports are combined in this document, and are presented along with introductory material.« less

Paradigm of Legal Protection of Computer Software Contracts in the United States: Brief Overview of “Principles of the Law of Software Contracts”

NASA Astrophysics Data System (ADS)

Furuya, Haruhisa; Hiratsuka, Mitsuyoshi

This article overviews the historical transition of legal protection of Computer software contracts in the Unite States and presents how it should function under Uniform Commercial Code and its amended Article 2B, Uniform Computer Information Transactions Act, and also recently-approved “Principles of the Law of Software Contracts”.

Fault-tolerant software - Experiment with the sift operating system. [Software Implemented Fault Tolerance computer

NASA Technical Reports Server (NTRS)

Brunelle, J. E.; Eckhardt, D. E., Jr.

1985-01-01

Results are presented of an experiment conducted in the NASA Avionics Integrated Research Laboratory (AIRLAB) to investigate the implementation of fault-tolerant software techniques on fault-tolerant computer architectures, in particular the Software Implemented Fault Tolerance (SIFT) computer. The N-version programming and recovery block techniques were implemented on a portion of the SIFT operating system. The results indicate that, to effectively implement fault-tolerant software design techniques, system requirements will be impacted and suggest that retrofitting fault-tolerant software on existing designs will be inefficient and may require system modification.

Software Issues at the User Interface

DTIC Science & Technology

1991-05-01

successful integration of parallel computers into mainstream scientific computing. Clearly a compiler is the most important software tool available to a...Computer Science University of Colorado Boulder, CO 80309 ABSTRACT We review software issues that are critical to the successful integration of parallel...The development of an optimizing compiler of this quality, addressing communicaton instructions as well as computational instructions is a major

Using satellite communications for a mobile computer network

NASA Technical Reports Server (NTRS)

Wyman, Douglas J.

1993-01-01

The topics discussed include the following: patrol car automation, mobile computer network, network requirements, network design overview, MCN mobile network software, MCN hub operation, mobile satellite software, hub satellite software, the benefits of patrol car automation, the benefits of satellite mobile computing, and national law enforcement satellite.

48 CFR 1852.227-19 - Commercial computer software-Restricted rights.

Code of Federal Regulations, 2013 CFR

2013-10-01

... software-Restricted rights. 1852.227-19 Section 1852.227-19 Federal Acquisition Regulations System NATIONAL... Provisions and Clauses 1852.227-19 Commercial computer software—Restricted rights. (a) As prescribed in 1827... regarding any computer software delivered under this contract/purchase order, the NASA Contracting Officer...

48 CFR 1852.227-19 - Commercial computer software-Restricted rights.

Code of Federal Regulations, 2010 CFR

2010-10-01

... software-Restricted rights. 1852.227-19 Section 1852.227-19 Federal Acquisition Regulations System NATIONAL... Provisions and Clauses 1852.227-19 Commercial computer software—Restricted rights. (a) As prescribed in 1827... regarding any computer software delivered under this contract/purchase order, the NASA Contracting Officer...

48 CFR 1852.227-19 - Commercial computer software-Restricted rights.

Code of Federal Regulations, 2011 CFR

2011-10-01

... software-Restricted rights. 1852.227-19 Section 1852.227-19 Federal Acquisition Regulations System NATIONAL... Provisions and Clauses 1852.227-19 Commercial computer software—Restricted rights. (a) As prescribed in 1827... regarding any computer software delivered under this contract/purchase order, the NASA Contracting Officer...

48 CFR 1852.227-19 - Commercial computer software-Restricted rights.

Code of Federal Regulations, 2012 CFR

2012-10-01

... software-Restricted rights. 1852.227-19 Section 1852.227-19 Federal Acquisition Regulations System NATIONAL... Provisions and Clauses 1852.227-19 Commercial computer software—Restricted rights. (a) As prescribed in 1827... regarding any computer software delivered under this contract/purchase order, the NASA Contracting Officer...

48 CFR 1852.227-19 - Commercial computer software-Restricted rights.

Code of Federal Regulations, 2014 CFR

2014-10-01

... software-Restricted rights. 1852.227-19 Section 1852.227-19 Federal Acquisition Regulations System NATIONAL... Provisions and Clauses 1852.227-19 Commercial computer software—Restricted rights. (a) As prescribed in 1827... regarding any computer software delivered under this contract/purchase order, the NASA Contracting Officer...

Computer and control applications in a vegetable processing plant

USDA-ARS?s Scientific Manuscript database

There are many advantages to the use of computers and control in food industry. Software in the food industry takes 2 forms - general purpose commercial computer software and software for specialized applications, such as drying and thermal processing of foods. Many applied simulation models for d...

IUWare and Computing Tools: Indiana University's Approach to Low-Cost Software.

ERIC Educational Resources Information Center

Sheehan, Mark C.; Williams, James G.

1987-01-01

Describes strategies for providing low-cost microcomputer-based software for classroom use on college campuses. Highlights include descriptions of the software (IUWare and Computing Tools); computing center support; license policies; documentation; promotion; distribution; staff, faculty, and user training; problems; and future plans. (LRW)

48 CFR 227.7103-7 - Use and non-disclosure agreement.

Code of Federal Regulations, 2010 CFR

2010-10-01

... release, disclosure, or authorized use of technical data or computer software subject to special license... (b) of this subsection, technical data or computer software delivered to the Government with..., display, or disclose technical data subject to limited rights or computer software subject to restricted...

29 CFR 541.401 - Computer manufacture and repair.

Code of Federal Regulations, 2011 CFR

2011-07-01

... DEFINING AND DELIMITING THE EXEMPTIONS FOR EXECUTIVE, ADMINISTRATIVE, PROFESSIONAL, COMPUTER AND OUTSIDE..., the use of computers and computer software programs (e.g., engineers, drafters and others skilled in computer-aided design software), but who are not primarily engaged in computer systems analysis and...

[Measurement of intracranial hematoma volume by personal computer].

PubMed

DU, Wanping; Tan, Lihua; Zhai, Ning; Zhou, Shunke; Wang, Rui; Xue, Gongshi; Xiao, An

2011-01-01

To explore the method for intracranial hematoma volume measurement by the personal computer. Forty cases of various intracranial hematomas were measured by the computer tomography with quantitative software and personal computer with Photoshop CS3 software, respectively. the data from the 2 methods were analyzed and compared. There was no difference between the data from the computer tomography and the personal computer (P>0.05). The personal computer with Photoshop CS3 software can measure the volume of various intracranial hematomas precisely, rapidly and simply. It should be recommended in the clinical medicolegal identification.

Bringing Legacy Visualization Software to Modern Computing Devices via Application Streaming

NASA Astrophysics Data System (ADS)

Fisher, Ward

2014-05-01

Planning software compatibility across forthcoming generations of computing platforms is a problem commonly encountered in software engineering and development. While this problem can affect any class of software, data analysis and visualization programs are particularly vulnerable. This is due in part to their inherent dependency on specialized hardware and computing environments. A number of strategies and tools have been designed to aid software engineers with this task. While generally embraced by developers at 'traditional' software companies, these methodologies are often dismissed by the scientific software community as unwieldy, inefficient and unnecessary. As a result, many important and storied scientific software packages can struggle to adapt to a new computing environment; for example, one in which much work is carried out on sub-laptop devices (such as tablets and smartphones). Rewriting these packages for a new platform often requires significant investment in terms of development time and developer expertise. In many cases, porting older software to modern devices is neither practical nor possible. As a result, replacement software must be developed from scratch, wasting resources better spent on other projects. Enabled largely by the rapid rise and adoption of cloud computing platforms, 'Application Streaming' technologies allow legacy visualization and analysis software to be operated wholly from a client device (be it laptop, tablet or smartphone) while retaining full functionality and interactivity. It mitigates much of the developer effort required by other more traditional methods while simultaneously reducing the time it takes to bring the software to a new platform. This work will provide an overview of Application Streaming and how it compares against other technologies which allow scientific visualization software to be executed from a remote computer. We will discuss the functionality and limitations of existing application streaming frameworks and how a developer might prepare their software for application streaming. We will also examine the secondary benefits realized by moving legacy software to the cloud. Finally, we will examine the process by which a legacy Java application, the Integrated Data Viewer (IDV), is to be adapted for tablet computing via Application Streaming.

NMRbox: A Resource for Biomolecular NMR Computation.

PubMed

Maciejewski, Mark W; Schuyler, Adam D; Gryk, Michael R; Moraru, Ion I; Romero, Pedro R; Ulrich, Eldon L; Eghbalnia, Hamid R; Livny, Miron; Delaglio, Frank; Hoch, Jeffrey C

2017-04-25

Advances in computation have been enabling many recent advances in biomolecular applications of NMR. Due to the wide diversity of applications of NMR, the number and variety of software packages for processing and analyzing NMR data is quite large, with labs relying on dozens, if not hundreds of software packages. Discovery, acquisition, installation, and maintenance of all these packages is a burdensome task. Because the majority of software packages originate in academic labs, persistence of the software is compromised when developers graduate, funding ceases, or investigators turn to other projects. To simplify access to and use of biomolecular NMR software, foster persistence, and enhance reproducibility of computational workflows, we have developed NMRbox, a shared resource for NMR software and computation. NMRbox employs virtualization to provide a comprehensive software environment preconfigured with hundreds of software packages, available as a downloadable virtual machine or as a Platform-as-a-Service supported by a dedicated compute cloud. Ongoing development includes a metadata harvester to regularize, annotate, and preserve workflows and facilitate and enhance data depositions to BioMagResBank, and tools for Bayesian inference to enhance the robustness and extensibility of computational analyses. In addition to facilitating use and preservation of the rich and dynamic software environment for biomolecular NMR, NMRbox fosters the development and deployment of a new class of metasoftware packages. NMRbox is freely available to not-for-profit users. Copyright © 2017 Biophysical Society. All rights reserved.

Seroprevalence of Antibodies against Human Herpesvirus 8 in a Population of Renal Transplant Recipients at Hôtel-Dieu de Québec Hospital

PubMed Central

Delorme, S.; Houde, I.; Deschênes, L.

2003-01-01

We conducted a seroepidemiologic study to determine the prevalence of anti-human herpesvirus 8 antibodies in a renal transplant population at Hôtel-Dieu de Québec Hospital. Testing for immunoglobulin G antibodies against lytic and latent antigens was performed on serum samples from 150 renal transplant patients. Human immunodeficiency virus-positive patients with confirmed Kaposi's sarcoma were used as positive controls. None of the renal transplant patients tested positive. PMID:14605164

Towards a Semantic Web of Community, Content and Interactions

DTIC Science & Technology

2005-09-01

importance of setting goals and deadlines as a means to achieving progress on the nebulous road to a dissertation. Jim Herbsleb sparked my interest in...RDF, such as Turtle [Bec04], a text syntax for RDF, and N-Triples [GDB04]. 45 </dc:creator> <dc:title>The Semantic Web: An Introduction</dc:title...2):22–41, 1990. 2.2.2 [Bec04] Dave Beckett. Turtle –terse rdf triple language. http://www.ilrt.bris.ac.uk/discovery/2004/01/ turtle /, January 2004. 4

Canonical ensemble ground state and correlation entropy of Bose-Einstein condensate

NASA Astrophysics Data System (ADS)

Svidzinsky, Anatoly; Kim, Moochan; Agarwal, Girish; Scully, Marlan O.

2018-01-01

Constraint of a fixed total number of particles yields a correlation between the fluctuation of particles in different states in the canonical ensemble. Here we show that, below the temperature of Bose-Einstein condensation (BEC), the correlation part of the entropy of an ideal Bose gas is cancelled by the ground-state contribution. Thus, in the BEC region, the thermodynamic properties of the gas in the canonical ensemble can be described accurately in a simplified model which excludes the ground state and assumes no correlation between excited levels.

Software for Real-Time Analysis of Subsonic Test Shot Accuracy

DTIC Science & Technology

2014-03-01

used the C++ programming language, the Open Source Computer Vision ( OpenCV ®) software library, and Microsoft Windows® Application Programming...video for comparison through OpenCV image analysis tools. Based on the comparison, the software then computed the coordinates of each shot relative to...DWB researchers wanted to use the Open Source Computer Vision ( OpenCV ) software library for capturing and analyzing frames of video. OpenCV contains

Software OT&E Guidelines. Volume 1. Software Test Manager’s Handbook

DTIC Science & Technology

1981-02-01

on reverse side If neceeary and identify by block number) The Software OT&E Guidelines is a set of handbooks prepared by the Computer / Support Systems...is one of a set of handbooks prepared by the Computer /Support Systems Division of the Test and Evaluation Directorate, Air Force Test and Evaluation...15 E. Software Maintainability .. .. ........ ... 16 F. Standard Questionnaires. .. .. ....... .... 16 1. Operator- Computer Interface Evaluation

Review of CAI Materials.

ERIC Educational Resources Information Center

McCrary, Ronald G.

A discussion of computer software and courseware for second-language instruction outlines considerations for selecting software of various kinds and presents a list of selected computer programs. Suggestions are made for choosing text-specific software, non-text-specific software intended for language instruction, word processors intended for…

Computers and Young Children. Storyboard Software: Flannel Boards in the Computer Age.

ERIC Educational Resources Information Center

Shade, Daniel D.

1995-01-01

Describes storyboard software as computer programs with which children can build a story using visuals. Notes the importance of such programs from preliterate or nonreading children. Describes a new storyboard program, "Wiggins in Storyland," and its features. Lists recommended storyboard software programs, with publishers and compatible…

Browsing Software of the Visible Korean Data Used for Teaching Sectional Anatomy

ERIC Educational Resources Information Center

Shin, Dong Sun; Chung, Min Suk; Park, Hyo Seok; Park, Jin Seo; Hwang, Sung Bae

2011-01-01

The interpretation of computed tomographs (CTs) and magnetic resonance images (MRIs) to diagnose clinical conditions requires basic knowledge of sectional anatomy. Sectional anatomy has traditionally been taught using sectioned cadavers, atlases, and/or computer software. The computer software commonly used for this subject is practical and…

Virus Alert: Ten Steps to Safe Computing.

ERIC Educational Resources Information Center

Gunter, Glenda A.

1997-01-01

Discusses computer viruses and explains how to detect them; discusses virus protection and the need to update antivirus software; and offers 10 safe computing tips, including scanning floppy disks and commercial software, how to safely download files from the Internet, avoiding pirated software copies, and backing up files. (LRW)

77 FR 50720 - Test Documentation for Digital Computer Software Used in Safety Systems of Nuclear Power Plants

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-22

... NUCLEAR REGULATORY COMMISSION [NRC-2012-0195] Test Documentation for Digital Computer Software...) is issuing for public comment draft regulatory guide (DG), DG-1207, ``Test Documentation for Digital... practices for test documentation for software and computer systems as described in the Institute of...