Pollution Swapping in Agricultural Systems: deciding between mitigation measures with conflicting outcomes

NASA Astrophysics Data System (ADS)

Quinton, John; Stevens, Carly

2010-05-01

Pollution swapping occurs when a mitigation option introduced to reduce one pollutant results in an increase in a different pollutant. Although the concept of pollution swapping is widely understood it has received little attention in research and policy design. This study investigated diffuse pollution mitigation options applied in combinable crop systems. They are: cover crops, residue management, no-tillage, riparian buffer zones, contour grass strips and constructed wetlands. A wide range of water and atmospheric pollutants were considered, including nitrogen, phosphorus, carbon and sulphur. It is clear from this investigation that there is no single mitigation option that will reduce all pollutants and in this poster we consider how choices may be made between mitigation measures which may have a positive effect on one pollutant but a negative effect on another.

Options of system integrated environment modelling in the predicated dynamic cyberspace

DOE Office of Scientific and Technical Information (OSTI.GOV)

Janková, Martina; Dvořák, Jiří

In this article there are briefly mentioned some selected options of contemporary conception of cybernetic system models in the corresponding and possible integratable environment with modern system dynamics thinking and all this in the cyberspace of possible projecting of predicted system characteristics. The key to new capabilities of system integration modelling in the considered cyberspace is mainly the ability to improve the environment and the system integration options, all this with the aim of modern control in the hierarchically arranged dynamic cyberspace, e.g. in the currently desired electronic business with information. The aim of this article is to assess generallymore » the trends in the use of modern modelling methods considering the cybernetics applications verified in practice, modern concept of project management and also the potential integration of artificial intelligence in the new projecting and project management of integratable and intelligent models, e.g. with the optimal structures and adaptable behaviour.The article results from the solution of a specific research partial task at the faculty; especially the moments proving that the new economics will be based more and more on information, knowledge system defined cyberspace of modern management, are stressed in the text.« less

Sizing and Lifecycle Cost Analysis of an Ares V Composite Interstage

NASA Technical Reports Server (NTRS)

Mann, Troy; Smeltzer, Stan; Grenoble, Ray; Mason, Brian; Rosario, Sev; Fairbairn, Bob

2012-01-01

The Interstage Element of the Ares V launch vehicle was sized using a commercially available structural sizing software tool. Two different concepts were considered, a metallic design and a composite design. Both concepts were sized using similar levels of analysis fidelity and included the influence of design details on each concept. Additionally, the impact of the different manufacturing techniques and failure mechanisms for composite and metallic construction were considered. Significant details were included in analysis models of each concept, including penetrations for human access, joint connections, as well as secondary loading effects. The designs and results of the analysis were used to determine lifecycle cost estimates for the two Interstage designs. Lifecycle cost estimates were based on industry provided cost data for similar launch vehicle components. The results indicated that significant mass as well as cost savings are attainable for the chosen composite concept as compared with a metallic option.

Fission Power System Technology for NASA Exploration Missions

NASA Technical Reports Server (NTRS)

Mason, Lee; Houts, Michael

2011-01-01

Under the NASA Exploration Technology Development Program, and in partnership with the Department of Energy (DOE), NASA is conducting a project to mature Fission Power System (FPS) technology. A primary project goal is to develop viable system options to support future NASA mission needs for nuclear power. The main FPS project objectives are as follows: 1) Develop FPS concepts that meet expected NASA mission power requirements at reasonable cost with added benefits over other options. 2) Establish a hardware-based technical foundation for FPS design concepts and reduce overall development risk. 3) Reduce the cost uncertainties for FPS and establish greater credibility for flight system cost estimates. 4) Generate the key products to allow NASA decisionmakers to consider FPS as a preferred option for flight development. In order to achieve these goals, the FPS project has two main thrusts: concept definition and risk reduction. Under concept definition, NASA and DOE are performing trade studies, defining requirements, developing analytical tools, and formulating system concepts. A typical FPS consists of the reactor, shield, power conversion, heat rejection, and power management and distribution (PMAD). Studies are performed to identify the desired design parameters for each subsystem that allow the system to meet the requirements with reasonable cost and development risk. Risk reduction provides the means to evaluate technologies in a laboratory test environment. Non-nuclear hardware prototypes are built and tested to verify performance expectations, gain operating experience, and resolve design uncertainties.

Long term orbital storage of cryogenic propellants for advanced space transportation missions

NASA Technical Reports Server (NTRS)

Schuster, John R.; Brown, Norman S.

1987-01-01

A comprehensive study has developed the major features of a large capacity orbital propellant depot for the space-based, cryogenic OTV. The study has treated both the Dual-Keel Space Station and co-orbiting platforms as the accommodations base for the propellant storage facilities, and trades have examined both tethered and hard-docked options. Five tank set concepts were developed for storing the propellants, and along with layout options for the station and platform, were evaluated from the standpoints of servicing, propellant delivery, boiloff, micrometeoroid/debris shielding, development requirements, and cost. These trades led to the recommendation that an all-passive storage concept be considered for the platform and an actively refrigerated concept providing for reliquefaction of all boiloff be considered for the Space Station. The tank sets are modular, each storing up to 45,400 kg of LO2/LH2, and employ many advanced features to provide for microgravity fluid management and to limit boiloff. The features include such technologies as zero-gravity mass gauging, total communication capillary liquid acquisition devices, autogenous pressurization, thermodynamic vent systems, thick multilayer insulation, vapor-cooled shields, solar-selective coatings, advanced micrometeoroid/debris protection systems, and long-lived cryogenic refrigeration systems.

Altair Lander Life Support: Design Analysis Cycles 1, 2, and 3

NASA Technical Reports Server (NTRS)

Anderson, Molly; Rotter, Hank; Stambaugh, Imelda; Curley, Su

2009-01-01

NASA is working to develop a new lunar lander to support lunar exploration. The development process that the Altair project is using for this vehicle is unlike most others. In Lander Design Analysis Cycle 1 (LDAC-1), a single-string, minimum functionality design concept was developed, including life support systems for different vehicle configuration concepts, first for a combination of an ascent vehicle and a habitat with integral airlocks, and then for a combined ascent vehicle-habitat with a detachable airlock. In LDAC-2, the Altair team took the ascent vehicle-habitat with detachable airlock and analyzed the design for the components that were the largest contributors to the risk of loss of crew (LOC). For life support, the largest drivers were related to oxygen supply and carbon dioxide control. Integrated abort options were developed at the vehicle level. Many life support failures were not considered to result in LOC because they had a long enough time to effect that abort was considered a feasible option to safely end the mission before the situation became life threatening. These failures were then classified as loss of mission (LOM) failures. Many options to reduce LOC risk were considered, and mass efficient solutions to the LOC problems were added to the vehicle design at the end of LDAC-2. In LDAC-3, the new design was analyzed for large contributors to the risk of LOM. To avoid ending the mission early or being unable to accomplish goals like performing all planned extravehicular activities (EVAs), various options were assessed for their combination of risk reduction and mass cost. This paper outlines the major assumptions, design features, and decisions related to the development of the life support system for the Altair project through LDAC-3.

Space Station power system issues

NASA Technical Reports Server (NTRS)

Giudici, R. J.

1985-01-01

Issues governing the selection of power systems for long-term manned Space Stations intended solely for earth orbital missions are covered briefly, drawing on trade study results from both in-house and contracted studies that have been conducted over nearly two decades. An involvement, from the Program Development Office at MSFC, with current Space Station concepts began in late 1982 with the NASA-wide Systems Definition Working Group and continued throughout 1984 in support of various planning activities. The premise for this discussion is that, within the confines of the current Space Station concept, there is good reason to consider photovoltaic power systems to be a venerable technology option for both the initial 75 kW and 300 kW (or much greater) growth stations. The issue of large physical size required by photovoltaic power systems is presented considering mass, atmospheric drag, launch packaging and power transmission voltage as being possible practicality limitations. The validity of searching for a cross-over point necessitating the introduction of solar thermal or nuclear power system options as enabling technologies is considered with reference to programs ranging from the 4.8 kW Skylab to the 9.5 gW Space Power Satellite.

JSC interactive basic accounting system

NASA Technical Reports Server (NTRS)

Spitzer, J. F.

1978-01-01

Design concepts for an interactive basic accounting system (IBAS) are considered in terms of selecting the design option which provides the best response at the lowest cost. Modeling the IBAS workload and applying this workload to a U1108 EXEC 8 based system using both a simulation model and the real system is discussed.

Wet soil cover applicability and design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hunter, F.; Feenstra, S.; Hwang, D.

1996-12-31

As part of a focused feasibility study for the Tyson Superfund site, Daekyoo Hwang, then with ERM, developed a flooding/flushing option. It was not considered a viable option due to concerns over contaminated groundwater control. The concept, however, had several attractive features: control of VOC emissions; the downward movement of water prevents contamination of the overlying clean soil by the upward movement of contaminated soil vapor; and some natural attenuation of the contaminated lagoon area soils. The new concept employs a near saturated soil layer to prevent VOC emission and the downward movement of water to prevent contamination of surfacemore » soil. The wet soil cover became one of five alternatives submitted as part of the focused feasibility study. It was selected as the remedial option for the site by the USEPA. The study was reviewed by the public and they also were positive as to the use of a wet soil cover to control VOC emissions at the site. The wet soil cover is currently being designed by Smith Environmental.« less

Emerging Options and Opportunities in Civilian Aeronautics

NASA Technical Reports Server (NTRS)

Bushnell, Dennis M.

2012-01-01

This paper addresses the major problems/issues with civilian aeronautics going forward, the contextual ongoing technology revolutions, the several emerging civilian aeronautical "Big Ideas" and associated enabling technological approaches. The ongoing IT Revolution is increasingly providing, as 5 senses virtual presence/reality becomes available, along with Nano/Molecular Manufacturing, virtual alternatives to Physical transportation for both people and goods. Paper examines the potential options available to aeronautics to maintain and perhaps grow "market share" in the context of this evolving competition. Many of these concepts are not new, but the emerging technology landscape is enhancing their viability and marketability. The concepts vary from the "interesting" to the truly revolutionary and all require considerable research. Paper considers the speed range from personal/general aviation to supersonic transports and technologies from energetics to fabrication.

MIUS community conceptual design study

NASA Technical Reports Server (NTRS)

Fulbright, B. E.

1976-01-01

The feasibility, practicality, and applicability of the modular integrated utility systems (MIUS) concept to a satellite new-community development with a population of approximately 100,000 were analyzed. Two MIUS design options, the 29-MIUS-unit (option 1) and the 8-MIUS-unit (option 2) facilities were considered. Each resulted in considerable resource savings when compared to a conventional utility system. Economic analyses indicated that the total cash outlay and operations and maintenance costs for these two options were considerably less than for a conventional system. Computer analyses performed in support of this study provided corroborative data for the study group. An environmental impact assessment was performed to determine whether the MIUS meets or will meet necessary environmental standards. The MIUS can provide improved efficiency in the conservation of natural resources while not adversely affecting the physical environment.

[Metacognition in psychotic disorders: from concepts to intervention].

PubMed

de Jong, S; van Donkersgoed, R J M; Arends, J; Lysaker, P H; Wunderink, L; van der Gaag, M; Aleman, A; Pijnenborg, G H M

2016-01-01

Persons with a psychotic disorder commonly experience difficulties with what is considered to be metacognitive capacity. In this article we discuss several definitions of this concept, the measurement instruments involved and the clinical interventions that target this concept. To present a review of various frequently used definitions of metacognition and related concepts and to describe the measurement instruments involved and the treatment options available for improving the metacognitive capacity of persons with a psychotic disorder. We present an overview of several definitions of metacognition in psychotic disorders and we discuss frequently used measurement instruments and treatment options. The article focuses on recent developments in a model devised by Semerari et al. The measurement instrument involved (Metacognition Assessment Scale - A) is discussed in terms of it being an addition to existing methods. On the basis of the literature it appears that metacognition and related concepts are measurable constructs, although definitions and instruments vary considerably. The new conceptualisation of social information processing also leads to the development of a new form of psychotherapy that aims to help patients suffering from psychotic disorders to improve metacognitive capacity. There seems to be evidence that metacognitive abilities are a possible target for treatment, but further research is needed.

Preliminary space station solar array structural design study

NASA Technical Reports Server (NTRS)

Dorsey, J. T.; Bush, H. G.; Mikulas, M. M., Jr.

1984-01-01

Structurally efficient ways to support the large solar arrays (3,716 square meters which are currently considered for space station use) are examined. An erectable truss concept is presented for the on orbit construction of winged solar arrays. The means for future growth, maintenance, and repair are integrally designed into this concept. Results from parametric studies, which highlight the physical and structural differences between various configuration options are presented. Consideration is given to both solar blanket and hard panel arrays.

Preliminary space station solar array structural design study

NASA Astrophysics Data System (ADS)

Dorsey, J. T.; Bush, H. G.; Mikulas, M. M., Jr.

Structurally efficient ways to support the large solar arrays (3,716 square meters which are currently considered for space station use) are examined. An erectable truss concept is presented for the on orbit construction of winged solar arrays. The means for future growth, maintenance, and repair are integrally designed into this concept. Results from parametric studies, which highlight the physical and structural differences between various configuration options are presented. Consideration is given to both solar blanket and hard panel arrays.

Application of the aqueous self-cooled blanket concept to fusion reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Deutsch, L.; Steiner, D.; Embrechts, M.J.

1986-01-01

The development of a reliable, safe, and economically attractive tritium breeding blanket is an essential requirement in the path to commercial fusion power. The primary objective of the recently completed Blanket Comparison and Selection Study (BCSS) was to evaluate previously proposed concepts, and thereby identify a limited number of preferred options that would provide the focus for an R and D program. The water-cooled concepts in the BCSS scored relatively low. We consider it prudent that a promising water-cooled blanket concept be included in this program since nearly all power producing reactors currently rely on water technology. It is inmore » this context that we propose the novel water-cooled blanket concept described herein.« less

Introducing Big Data Concepts in an Introductory Technology Course

ERIC Educational Resources Information Center

Frydenberg, Mark

2015-01-01

From their presence on social media sites to in-house application data files, the amount of data that companies, governments, individuals, and sensors generate is overwhelming. The growth of Big Data in both consumer and enterprise activities has caused educators to consider options for including Big Data in the Information Systems curriculum.…

How to Tackle Tough Facility Design Considerations

ERIC Educational Resources Information Center

Kalina, David

2007-01-01

This article is part of a series that has offered insight on planning a facilities project, hiring professionals, delivery system options and owner's responsibilities. In this article, the author focuses on some of the planning and design concepts one may be asked to consider in providing direction to his design and construction team. These…

The Need for High Speed in Next Generation Rotorcraft

DTIC Science & Technology

2012-03-01

ROTORCRAFT From the earliest thought of manned flight the helicopter was considered as a viable option to satisfy the requirement for flight. Leonardo Da... Vinci first dreamed of the helicopter flight concept in the year 1480. His adaption of the flying machine, named the "Helical Air Screw,” used the

Teaching Entrepreneurship to Children: A Case Study

ERIC Educational Resources Information Center

do Paco, Arminda; Palinhas, Maria Joao

2011-01-01

Nowadays few young people are prepared to consider setting up and managing their own business as a realistic and attractive career option. It is therefore necessary to expose children to the concept of entrepreneurship from a very early age, which means that the school has a fundamental role to play in this task. This research seeks to understand…

Gallium arsenide (GaAs) power conversion concept

NASA Technical Reports Server (NTRS)

Nussberger, A. A.

1980-01-01

A summary design analysis of a GaAs power conversion system for the solar power satellite (SPS) is presented. Eight different satellite configuration options for the solar arrays are compared. Solar cell annealing effects after proton irradiation are considered. Mass estimates for the SPS and the effect of solar cell parameters on SPS array design are discussed.

Fission Surface Power System Initial Concept Definition

NASA Technical Reports Server (NTRS)

2010-01-01

Under the NASA Exploration Technology Development Program (ETDP) and in partnership with the Department of Energy (DOE), NASA has embarked on a project to develop Fission Surface Power (FSP) technology. The primary goals of the project are to 1) develop FSP concepts that meet expected surface power requirements at reasonable cost with added benefits over other options, 2) establish a hardwarebased technical foundation for FSP design concepts and reduce overall development risk, 3) reduce the cost uncertainties for FSP and establish greater credibility for flight system cost estimates, and 4) generate the key products to allow NASA decision-makers to consider FSP as a preferred option for flight development. The FSP project was initiated in 2006 as the Prometheus Program and the Jupiter Icy Moons Orbiter (JIMO) mission were phased-out. As a first step, NASA Headquarters commissioned the Affordable Fission Surface Power System Study to evaluate the potential for an affordable FSP development approach. With a cost-effective FSP strategy identified, the FSP team evaluated design options and selected a Preliminary Reference Concept to guide technology development. Since then, the FSP Preliminary Reference Concept has served as a point-of-departure for several NASA mission architecture studies examining the use of nuclear power and has provided the foundation for a series of "Pathfinder" hardware tests. The long-term technology goal is a Technology Demonstration Unit (TDU) integrated system test using full-scale components and a non-nuclear reactor simulator. The FSP team consists of Glenn Research Center (GRC), Marshall Space Flight Center (MSFC) and the DOE National Laboratories at Los Alamos (LANL), Idaho (INL), Oak Ridge (ORNL), and Sandia (SNL). The project is organized into two main elements: Concept Definition and Risk Reduction. Under Concept Definition, the team performs trade studies, develops analytical tools, and formulates system concepts. Under Risk Reduction the team develops hardware prototypes and conducts laboratory-based testing.

Laser engines operating by resonance absorption. [thermodynamic feasibility study

NASA Technical Reports Server (NTRS)

Garbuny, M.; Pechersky, M. J.

1976-01-01

Basic tutorial article on the thermodynamic feasibility of laser engines at the present state of the art. Three main options are considered: (1) laser power applied externally to a heat reservoir (boiler approach); (2) internal heating of working fluid by resonance absorption; and (3) direct conversion of selective excitation into work. Only (2) is considered practically feasible at present. Basic concepts and variants, efficiency relations, upper temperature limits of laser engines, selection of absorbing gases, engine walls, bleaching, thermodynamic cycles of optimized laser engines, laser-powered turbines, laser heat pumps are discussed. Photon engines and laser dissociation engines are also considered.

Transferability of Graduate Work Graded according to Mastery. A Survey of Selected Graduate Faculty and Institutions.

ERIC Educational Resources Information Center

Stout State Univ., Menomonie, WI. Graduate School.

The Graduate College at Stout State University is considering an option to the present A-F grading system called "Mastery Grading," based on a concept called "teaching for mastery." This involves carefully defining each course in terms of the specific competencies which the student is expected to develop as a result of…

Feasibility of modern airships - Preliminary assessment

NASA Technical Reports Server (NTRS)

Ardema, M. D.

1977-01-01

Attention is given to the NASA program, Feasibility Study of Modern Airships, initiated to investigate potential research and technology programs associated with airship development. A historical survey of the program is presented, including the development of past airship concepts, aerodynamical and design improvements, structure and material concepts, and research in controls, avionics, instrumentation, flight operations, and ground handling. A mission analysis was carried out which considered passenger and cargo transportation, heavy-lift, short-haul applications, surveillance missions, and the transportation of natural gas. A vehicle parametric analysis examined the entire range of airship concepts, discussing both conventional airships and hybrids. Various design options were evaluated, such as choice of structural materials, use of boundary-layer control, and choice of lifting gas.

Alternate Approaches to Exploration: The Single Crew Module Concept

NASA Technical Reports Server (NTRS)

Chambliss, Joe

2011-01-01

The Cx Program envisioned exploration of the moon and mars using an extrapolation of the Apollo approach. If new technology development initiatives are successful, they will provide capabilities that can enable alternate approaches. This presentation will provide a brief overview of the Cx approaches for lunar and Mars missions and some of the alternatives that were considered. Then an alternative approach referred to as a Single Crew Module approach is described. The SCM concept employs new technologies in a way that could reduce exploration cost and possibly schedule. Options to the approaches will be presented and discussed.

Tailoring of the care concept for practicality, safety and robustness

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kawamura, Hideki; McKinley, Ian G

2013-07-01

The Cavern Retrievable (CARE) concept was originally developed to provide flexibility in tailoring disposal of vitrified HLW to small volunteer host sites, where high emplacement density leads to significant challenges in terms of the management of radiogenic heat. Including an extended storage period in underground caverns prior to sealing solved the heat issue, but also provided benefits in terms of a slow decision-making process that provided more opportunities to engage stakeholders. Recently, direct disposal of spent fuel is being considered in Japan and this gives more severe challenges for heat management, even for conventional disposal concepts. Due to great uncertaintiesmore » in the future of nuclear power in Japan, this may also be associated with a desire to preserve the option of retrieval for extended periods. The basic CARE concept has thus been re-assessed to consider these aspects - and also the need to be able to develop a robust safety case that can be readily communicated to stakeholders, who are more sensitive to nuclear issues than they were in the past. (authors)« less

SP-100 power system conceptual design for lunar base applications

NASA Technical Reports Server (NTRS)

Mason, Lee S.; Bloomfield, Harvey S.; Hainley, Donald C.

1989-01-01

A conceptual design is presented for a nuclear power system utilizing an SP-100 reactor and multiple Stirling cycle engines for operation on the lunar surface. Based on the results of this study, it was concluded that this power plant could be a viable option for an evolutionary lunar base. The design concept consists of a 2500 kWt (kilowatt thermal) SP-100 reactor coupled to eight free-piston Stirling engines. Two of the engines are held in reserve to provide conversion system redundancy. The remaining engines operate at 91.7 percent of their rated capacity of 150 kWe. The design power level for this system is 825 kWe. Each engine has a pumped heat-rejection loop connected to a heat pipe radiator. Power system performance, sizing, layout configurations, shielding options, and transmission line characteristics are described. System components and integration options are compared for safety, high performance, low mass, and ease of assembly. The power plant was integrated with a proposed human lunar base concept to ensure mission compatibility. This study should be considered a preliminary investigation; further studies are planned to investigate the effect of different technologies on this baseline design.

Candidate CDTI procedures study

NASA Technical Reports Server (NTRS)

Ace, R. E.

1981-01-01

A concept with potential for increasing airspace capacity by involving the pilot in the separation control loop is discussed. Some candidate options are presented. Both enroute and terminal area procedures are considered and, in many cases, a technologically advanced Air Traffic Control structure is assumed. Minimum display characteristics recommended for each of the described procedures are presented. Recommended sequencing of the operational testing of each of the candidate procedures is presented.

Next Generation Heavy-Lift Launch Vehicle: Large Diameter, Hydrocarbon-Fueled Concepts

NASA Technical Reports Server (NTRS)

Holliday, Jon; Monk, Timothy; Adams, Charles; Campbell, Ricky

2012-01-01

With the passage of the 2010 NASA Authorization Act, NASA was directed to begin the development of the Space Launch System (SLS) as a follow-on to the Space Shuttle Program. The SLS is envisioned as a heavy lift launch vehicle that will provide the foundation for future large-scale, beyond low Earth orbit (LEO) missions. Supporting the Mission Concept Review (MCR) milestone, several teams were formed to conduct an initial Requirements Analysis Cycle (RAC). These teams identified several vehicle concept candidates capable of meeting the preliminary system requirements. One such team, dubbed RAC Team 2, was tasked with identifying launch vehicles that are based on large stage diameters (up to the Saturn V S-IC and S-II stage diameters of 33 ft) and utilize high-thrust liquid oxygen (LOX)/RP engines as a First Stage propulsion system. While the trade space for this class of LOX/RP vehicles is relatively large, recent NASA activities (namely the Heavy Lift Launch Vehicle Study in late 2009 and the Heavy Lift Propulsion Technology Study of 2010) examined specific families within this trade space. Although the findings from these studies were incorporated in the Team 2 activity, additional branches of the trade space were examined and alternative approaches to vehicle development were considered. Furthermore, Team 2 set out to define a highly functional, flexible, and cost-effective launch vehicle concept. Utilizing this approach, a versatile two-stage launch vehicle concept was chosen as a preferred option. The preferred vehicle option has the capability to fly in several different configurations (e.g. engine arrangements) that gives this concept an inherent operational flexibility which allows the vehicle to meet a wide range of performance requirements without the need for costly block upgrades. Even still, this concept preserves the option for evolvability should the need arise in future mission scenarios. The foundation of this conceptual design is a focus on low cost and effectiveness rather than efficiency or cutting-edge technology. This paper details the approach and process, as well as the trade space analysis, leading to the preferred vehicle concept.

Concept Design of High Power Solar Electric Propulsion Vehicles for Human Exploration

NASA Technical Reports Server (NTRS)

Hoffman, David J.; Kerslake, Thomas W.; Hojnicki, Jeffrey S.; Manzella, David H.; Falck, Robert D.; Cikanek, Harry A., III; Klem, Mark D.; Free, James M.

2011-01-01

Human exploration beyond low Earth orbit will require enabling capabilities that are efficient, affordable and reliable. Solar electric propulsion (SEP) has been proposed by NASA s Human Exploration Framework Team as one option to achieve human exploration missions beyond Earth orbit because of its favorable mass efficiency compared to traditional chemical propulsion systems. This paper describes the unique challenges associated with developing a large-scale high-power (300-kWe class) SEP vehicle and design concepts that have potential to meet those challenges. An assessment of factors at the subsystem level that must be considered in developing an SEP vehicle for future exploration missions is presented. Overall concepts, design tradeoffs and pathways to achieve development readiness are discussed.

Modified Policy-Delphi study for exploring obesity prevention priorities

PubMed Central

Haynes, Emily; Palermo, Claire; Reidlinger, Dianne P

2016-01-01

Introduction Until now, industry and government stakeholders have dominated public discourse about policy options for obesity. While consumer involvement in health service delivery and research has been embraced, methods which engage consumers in health policy development are lacking. Conflicting priorities have generated ethical concern around obesity policy. The concept of ‘intrusiveness’ has been applied to policy decisions in the UK, whereby ethical implications are considered through level of intrusiveness to choice; however, the concept has also been used to avert government regulation to address obesity. The concept of intrusiveness has not been explored from a stakeholder's perspective. The aim is to investigate the relevance of intrusiveness and autonomy to health policy development, and to explore consensus on obesity policy priorities of under-represented stakeholders. Methods and analysis The Policy-Delphi technique will be modified using the James Lind Alliance approach to collaborative priority setting. A total of 60 participants will be recruited to represent three stakeholder groups in the Australian context: consumers, public health practitioners and policymakers. A three-round online Policy-Delphi survey will be undertaken. Participants will prioritise options informed by submissions to the 2009 Australian Government Inquiry into Obesity, and rate the intrusiveness of those proposed. An additional round will use qualitative methods in a face-to-face discussion group to explore stakeholder perceptions of the intrusiveness of options. The novelty of this methodology will redress the balance by bringing the consumer voice forward to identify ethically acceptable obesity policy options. Ethics and dissemination Ethical approval was granted by the Bond University Health Research Ethics Committee. The findings will inform development of a conceptual framework for analysing and prioritising obesity policy options, which will be relevant internationally and to ethical considerations of wider public health issues. The findings will be disseminated through peer-reviewed publications, conference presentations and collaborative platforms of policy and science. PMID:27601495

Modified Policy-Delphi study for exploring obesity prevention priorities.

PubMed

Haynes, Emily; Palermo, Claire; Reidlinger, Dianne P

2016-09-06

Until now, industry and government stakeholders have dominated public discourse about policy options for obesity. While consumer involvement in health service delivery and research has been embraced, methods which engage consumers in health policy development are lacking. Conflicting priorities have generated ethical concern around obesity policy. The concept of 'intrusiveness' has been applied to policy decisions in the UK, whereby ethical implications are considered through level of intrusiveness to choice; however, the concept has also been used to avert government regulation to address obesity. The concept of intrusiveness has not been explored from a stakeholder's perspective. The aim is to investigate the relevance of intrusiveness and autonomy to health policy development, and to explore consensus on obesity policy priorities of under-represented stakeholders. The Policy-Delphi technique will be modified using the James Lind Alliance approach to collaborative priority setting. A total of 60 participants will be recruited to represent three stakeholder groups in the Australian context: consumers, public health practitioners and policymakers. A three-round online Policy-Delphi survey will be undertaken. Participants will prioritise options informed by submissions to the 2009 Australian Government Inquiry into Obesity, and rate the intrusiveness of those proposed. An additional round will use qualitative methods in a face-to-face discussion group to explore stakeholder perceptions of the intrusiveness of options. The novelty of this methodology will redress the balance by bringing the consumer voice forward to identify ethically acceptable obesity policy options. Ethical approval was granted by the Bond University Health Research Ethics Committee. The findings will inform development of a conceptual framework for analysing and prioritising obesity policy options, which will be relevant internationally and to ethical considerations of wider public health issues. The findings will be disseminated through peer-reviewed publications, conference presentations and collaborative platforms of policy and science. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Transportation: Destination Mars

NASA Technical Reports Server (NTRS)

Eoff, Bill

1998-01-01

As the agency space transportation lead center, Marshall Space Flight Center has been conducting transportation assessments for future robotic and human Mars missions to identify critical technologies. Five human Mars options are currently under assessment with each option including all transportation requirements from Earth to Mars and return. The primary difference for each option is the propulsion source from Earth to Mars. In case any of the options require heavy launch capability that is not currently projected as available, an in-house study has been initiated to determine the most cost effective means of providing such launch capability. This assessment is only considering launch architectures that support the overall human Mars mission cost goal of $25B. The guidelines for the launch capability study included delivery of 80 metric ton (176 KLB) payloads, 25 feet diameter x 92 feet long, to 220 nmi orbits at 28.5 degrees. The launch vehicle concept of the study was designated "Magnum" to differentiate from prior heavy launch vehicle assessments. This assessment along with the assessment of options for all transportation phases of a Mars mission are on-going.

Study to define an approach for developing a computer-based system capable of automatic, unattended assembly/disassembly of spacecraft, phase 1

NASA Technical Reports Server (NTRS)

Nevins, J. L.; Defazio, T. L.; Seltzer, D. S.; Whitney, D. E.

1981-01-01

The initial set of requirements for additional studies necessary to implement a space-borne, computer-based work system capable of achieving assembly, disassembly, repair, or maintenance in space were developed. The specific functions required of a work system to perform repair and maintenance were discussed. Tasks and relevant technologies were identified and delineated. The interaction of spacecraft design and technology options, including a consideration of the strategic issues of repair versus retrieval-replacement or destruction by removal were considered along with the design tradeoffs for accomplishing each of the options. A concept system design and its accompanying experiment or test plan were discussed.

Multiple main-belt asteroid mission options for a Mariner Mark II spacecraft

NASA Astrophysics Data System (ADS)

Sauer, Carl G., Jr.; Yen, Chen-Wan L.

This paper presents the trajectory options available for a MMII spacecraft mission to asteroids and introduces systematic methods of uncovering attractive mission opportunities. The analysis presented considers multiple synchronous gravity assists of Mars and introduces a terminal resonant or phasing orbit; a concept useful for both increasing the number of asteroid rendezvous targets attainable during a launch opportunity, and also in increasing the number of potential asteroid flybys. Systematic examinations of the requirements for superior asteroidal alignments are made and a comprehensive set of asteroid rendezvous opportunities for the 1998 to 2010 period are presented. Examples of candidate missions involving one or more rendezvous and several flybys are also presented.

Multiple main-belt asteroid mission options for a Mariner Mark II spacecraft

NASA Technical Reports Server (NTRS)

Sauer, Carl G., Jr.; Yen, Chen-Wan L.

1990-01-01

This paper presents the trajectory options available for a MMII spacecraft mission to asteroids and introduces systematic methods of uncovering attractive mission opportunities. The analysis presented considers multiple synchronous gravity assists of Mars and introduces a terminal resonant or phasing orbit; a concept useful for both increasing the number of asteroid rendezvous targets attainable during a launch opportunity, and also in increasing the number of potential asteroid flybys. Systematic examinations of the requirements for superior asteroidal alignments are made and a comprehensive set of asteroid rendezvous opportunities for the 1998 to 2010 period are presented. Examples of candidate missions involving one or more rendezvous and several flybys are also presented.

Analysis of digester design concepts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ashare, E.; Wilson, E. H.

1979-01-29

Engineering economic analyses were performed on various digester design concepts to determine the relative performance for various biomass feedstocks. A comprehensive literature survey describing the state-of-the-art of the various digestion designs is included. The digester designs included in the analyses are CSTR, plug flow, batch, CSTR in series, multi-stage digestion and biomethanation. Other process options investigated included pretreatment processes such as shredding, degritting, and chemical pretreatment, and post-digestion processes, such as dewatering and gas purification. The biomass sources considered include feedlot manure, rice straw, and bagasse. The results of the analysis indicate that the most economical (on a unit gasmore » cost basis) digester design concept is the plug flow reactor. This conclusion results from this system providing a high gas production rate combined with a low capital hole-in-the-ground digester design concept. The costs determined in this analysis do not include any credits or penalties for feedstock or by-products, but present the costs only for conversion of biomass to methane. The batch land-fill type digester design was shown to have a unit gas cost comparable to that for a conventional stirred tank digester, with the potential of reducing the cost if a land-fill site were available for a lower cost per unit volume. The use of chemical pretreatment resulted in a higher unit gas cost, primarily due to the cost of pretreatment chemical. A sensitivity analysis indicated that the use of chemical pretreatment could improve the economics provided a process could be developed which utilized either less pretreatment chemical or a less costly chemical. The use of other process options resulted in higher unit gas costs. These options should only be used when necessary for proper process performance, or to result in production of a valuable by-product.« less

Effluent treatment for nuclear thermal propulsion ground testing

NASA Technical Reports Server (NTRS)

Shipers, Larry R.

1993-01-01

The objectives are to define treatment functions, review concept options, discuss PIPET effluent treatment system (ETS), and outline future activities. The topics covered include the following: reactor exhaust; effluent treatment functions; effluent treatment categories; effluent treatment options; concept evaluation; PIPETS ETS envelope; PIPET effluent treatment concept; and future activities.

Is the shortened dental arch still a satisfactory option?

PubMed

Manola, M; Hussain, F; Millar, B J

2017-07-21

Aims Dental practitioners may hold the view that missing posterior teeth should be replaced to ensure a healthy masticatory system and satisfactory oral function. However, the shortened dental arch (SDA) concept is still in use, but after 35 years is it acceptable? This review searches the literature for the evidence and opinions regarding the suitability of the SDA as a current treatment modality.Methods Medline and PubMed databases were searched for relevant terms, all the abstracts were assessed and articles selected according to the pre-set exclusion and inclusion criteria.Results The search yielded 1,895 articles and after the assessment of the abstracts and application of the exclusion and inclusion criteria, 44 articles were selected for this review. These included 11 cohort studies, two longitudinal studies, two animal studies, three cross sectional studies, eight clinical studies and 18 case control studies. There appears to be a trend over the past three decades for more papers to be opposed to the SDA concept.Conclusion Evidence that the SDA causes pathology is lacking. Clinicians, healthcare authorities and patients have shown favourable attitudes towards the SDA and this continues, although there is an increase in studies opposing the concept and some are dissatisfied with this option. The concept remains viable particularly for the medically compromised patient or where restorations are considered unsuitable but further more specific studies are warranted.

In-situ Resource Utilization (ISRU) to Support the Lunar Outpost and the Rationale for Precursor Missions

NASA Technical Reports Server (NTRS)

Simon, Thomas M.

2008-01-01

One of the ways that the Constellation Program can differ from Apollo is to employ a live-off-the-land or In-Situ Resource Utilization (ISRU) supported architecture. The options considered over the past decades for using indigenous materials have varied considerably in terms of what resources to attempt to acquire, how much to acquire, and what the motivations are to acquiring these resources. The latest NASA concepts for supporting the lunar outpost have considered many of these plans and compared these options to customers requirements and desires. Depending on the architecture employed, ISRU technologies can make a significant contribution towards a sustainable and affordable lunar outpost. While extensive ground testing will reduce some mission risk, one or more flight demonstrations prior to the first crew's arrival will build confidence and increase the chance that outpost architects will include ISRU as part of the early outpost architecture. This presentation includes some of the options for using ISRU that are under consideration for the lunar outpost, the precursor missions that would support these applications, and a notional timeline to allow the lessons learned from the precursor missions to support outpost hardware designs.

Satellite services system analysis study. Volume 4: Service equipment concepts

NASA Technical Reports Server (NTRS)

1981-01-01

Payload deployment equipment is discussed, including payload separation, retention structures, the remote manipulator system, tilt tables, the payload installation and deployment aid, the handling and positioning aid, and spin tables. Close proximity retrieval, and on-orbit servicing equipment is discussed. Backup and contingency equipment is also discussed. Delivery and retrieval of high-energy payloads are considered. Earth return equipment, the aft flight deck, optional, and advanced equipment are also discussed.

Extracorporeal photopheresis: Review of technical aspects.

PubMed

Arora, Satyam; Setia, Rasika

2017-01-01

Extracorporeal photochemotherapy (ECP) is considered as an immune modulating therapy majorly targeting the T cells of the Immune system. ECP induces an anti-inflammatory condition with tolerogenic responses without inducing a global immunosuppression state which is a typical feature of other therapeutic options such as steroids. Clinical indication of ECP has grown over time since its initial applications. Our review discusses the technical aspects of the concept of photopheresis with the available methods for its clinical applications.

Proximity Operations for the Robotic Boulder Capture Option for the Asteroid Redirect Mission

NASA Technical Reports Server (NTRS)

Reeves, David M.; Naasz, Bo J.; Wright, Cinnamon A.; Pini, Alex J.

2014-01-01

In September of 2013, the Asteroid Robotic Redirect Mission (ARRM) Option B team was formed to expand on NASA's previous work on the robotic boulder capture option. While the original Option A concept focuses on capturing an entire smaller Near-Earth Asteroid (NEA) using an inflatable bag capture mechanism, this design seeks to land on a larger NEA and retrieve a boulder off of its surface. The Option B team has developed a detailed and feasible mission concept that preserves many aspects of Option A's vehicle design while employing a fundamentally different technique for returning a significant quantity of asteroidal material to the Earth-Moon system. As part of this effort, a point of departure proximity operations concept was developed complete with a detailed timeline, as well as DeltaV and propellant allocations. Special attention was paid to the development of the approach strategy, terminal descent to the surface, controlled ascent with the captured boulder, and control during the Enhanced Gravity Tractor planetary defense demonstration. The concept of retrieving a boulder from the surface of an asteroid and demonstrating the Enhanced Gravity Tractor planetary defense technique is found to be feasible and within the proposed capabilities of the Asteroid Redirect Vehicle (ARV). While this point of departure concept initially focuses on a mission to Itokawa, the proximity operations design is also shown to be extensible to wide range of asteroids.

Evaluation of a metal shear web selectively reinforced with filamentary composites for space shuttle application. Phase 3 Summary report: Shear web component testing and analysis

NASA Technical Reports Server (NTRS)

Laakso, J. H.; Straayer, J. W.

1973-01-01

Three large scale advanced composite shear web components were tested and analyzed to evaluate application of the design concept to a space shuttle orbiter thrust structure. The shear web design concept consisted of a titanium-clad + or - 45 deg boron/epoxy web laminate stiffened with vertical boron/epoxy reinforced aluminum stiffeners. The design concept was evaluated to be efficient and practical for the application that was studied. Because of the effects of buckling deflections, a requirement is identified for shear buckling resistant design to maximize the efficiency of highly-loaded advanced composite shear webs. An approximate analysis of prebuckling deflections is presented and computer-aided design results, which consider prebuckling deformations, indicate that the design concept offers a theoretical weight saving of 31 percent relative to all metal construction. Recommendations are made for design concept options and analytical methods that are appropriate for production hardware.

The German joint research project "concepts for future gravity satellite missions"

NASA Astrophysics Data System (ADS)

Reubelt, Tilo; Sneeuw, Nico; Fichter, Walter; Müller, Jürgen

2010-05-01

Within the German joint research project "concepts for future gravity satellite missions", funded by the Geotechnologies programme of the German Federal Ministry of Education and Research, options and concepts for future satellite missions for precise (time-variable) gravity field recovery are investigated. The project team is composed of members from science and industry, bringing together experts in geodesy, satellite systems, metrology, sensor technology and control systems. The majority of team members already contributed to former gravity missions. The composition of the team guarantees that not only geodetic aspects and objectives are investigated, but also technological and financial constraints are considered. Conversely, satellite, sensor and system concepts are developed and improved in a direct exchange with geodetic and scientific claims. The project aims to develop concepts for both near and mid-term future satellite missions, taking into account e.g. advanced satellite formations and constellations, improved orbit design, innovative metrology and sensor systems and advances in satellite systems.

Space Station needs, attributes and architectural options. Volume 2, book 2, part 1: Mission implementation concepts

NASA Technical Reports Server (NTRS)

1983-01-01

The overall configuration and modules of the initial and evolved space station are described as well as tended industrial and polar platforms. The mass properties that are the basis for costing are summarized. User friendly attributes (interfaces, resources, and facilities) are identified for commercial; science and applications; industrial park; international participation; national security; and the external tank option. Configuration alternates studied to determine a baseline are examined. Commonality for clustered 3-man and 9-man stations are considered as well as the use of tethered platforms. Requirements are indicated for electrical, communication and tracking; data management Subsystem requirements for electrical, data management, communication and tracking, environment control/life support system; and guidance navigation and control subsystems are identified.

Space Station needs, attributes and architectural options. Volume 2, book 2, part 1: Mission implementation concepts

NASA Astrophysics Data System (ADS)

1983-04-01

The overall configuration and modules of the initial and evolved space station are described as well as tended industrial and polar platforms. The mass properties that are the basis for costing are summarized. User friendly attributes (interfaces, resources, and facilities) are identified for commercial; science and applications; industrial park; international participation; national security; and the external tank option. Configuration alternates studied to determine a baseline are examined. Commonality for clustered 3-man and 9-man stations are considered as well as the use of tethered platforms. Requirements are indicated for electrical, communication and tracking; data management Subsystem requirements for electrical, data management, communication and tracking, environment control/life support system; and guidance navigation and control subsystems are identified.

The extension of the thermal-vacuum test optimization program to multiple flights

NASA Technical Reports Server (NTRS)

Williams, R. E.; Byrd, J.

1981-01-01

The thermal vacuum test optimization model developed to provide an approach to the optimization of a test program based on prediction of flight performance with a single flight option in mind is extended to consider reflight as in space shuttle missions. The concept of 'utility', developed under the name of 'availability', is used to follow performance through the various options encountered when the capabilities of reflight and retrievability of space shuttle are available. Also, a 'lost value' model is modified to produce a measure of the probability of a mission's success, achieving a desired utility using a minimal cost test strategy. The resulting matrix of probabilities and their associated costs provides a means for project management to evaluate various test and reflight strategies.

Integrated residential photovoltaic array development

NASA Astrophysics Data System (ADS)

Shepard, N. F., Jr.

1981-02-01

An optimum integrated residential photovoltaic array/module is addressed. Nineteen existing or proposed systems intended for residential applications are described. Each of these systems is rated against a comprehensive set of evaluation criteria in an effort to formulate three module design concepts for further study and analysis. This evaluation led to a number of observations which are enumerated and should be considered in future module and array designs. Three module concepts are presented as baseline design approaches to be further analyzed and optimized. These options include: (1) a rectangular, direct mounted, shingle type module; (2) an integrally mounted module with nonconductive exposed elements; and (3) an aluminum framed, stand off module. Preliminary design drawings are presented for each of these module configurations.

Integrated residential photovoltaic array development

NASA Technical Reports Server (NTRS)

Shepard, N. F., Jr.

1981-01-01

An optimum integrated residential photovoltaic array/module is addressed. Nineteen existing or proposed systems intended for residential applications are described. Each of these systems is rated against a comprehensive set of evaluation criteria in an effort to formulate three module design concepts for further study and analysis. This evaluation led to a number of observations which are enumerated and should be considered in future module and array designs. Three module concepts are presented as baseline design approaches to be further analyzed and optimized. These options include: (1) a rectangular, direct mounted, shingle type module; (2) an integrally mounted module with nonconductive exposed elements; and (3) an aluminum framed, stand off module. Preliminary design drawings are presented for each of these module configurations.

A Program Manager’s Guide for Program Improvement in Ongoing Psychological Health and Traumatic Brain Injury Programs. The RAND Toolkit, Volume 4

DTIC Science & Technology

2014-01-01

Hughes EFX, Boerstler H, O’Connor EJ. “Assessing the Impact of Continuous Quality Improvement/ Total Quality Management : Concept versus...facing the public and private sectors. All RAND reports undergo rigorous peer review to ensure high standards for research quality and objectivity. Gery...RAND Program Manager’s Guide helps managers assess program performance, consider options for improvement, implement solutions, then assess whether the

Space Station crew safety alternatives study. Volume 2: Threat development

NASA Technical Reports Server (NTRS)

Raasch, R. F.; Peercy, R. L., Jr.; Rockoff, L. A.

1985-01-01

The first 15 years of accumulated space station concepts for initial operational capability (IOC) during the early 1990's were considered. Twenty-five threats to the space station are identified and selected threats addressed as impacting safety criteria, escape and rescue, and human factors safety concerns. Of the 25 threats identified, eight are discussed including strategy options for threat control: fire, biological or toxic contamination, injury/illness, explosion, loss of pressurization, radiation, meteoroid penetration, and debris.

Space station crew safety alternatives study, volume 1

NASA Technical Reports Server (NTRS)

Peercy, R. L., Jr.; Raasch, R. F.; Rockoff, L. A.

1985-01-01

The first 15 years of accumulated space station concepts for initial operational capability (IOC) during the early 1990's were considered. Twenty-five threats to the space station are identified and selected threats addressed as impacting safety criteria, escape and rescue, and human factors safety concerns. Of the 25 threats identified, eight are discussed including strategy options for threat control: fire, biological or toxic contamination, injury/illness, explosion, loss of pressurization, radiation, meteoroid penetration and debris.

Conceptual design studies for surface infrastructure

NASA Technical Reports Server (NTRS)

Bufkin, Ann L.; Jones, William R., II

1986-01-01

The utimate design of a manned Mars base will be the result of considerable engineering analysis and many trade studies to optimize the configuration. Many options and scenarios are available and all need to be considered at this time. Initial base elements, two base configuration concepts, internal space architectural concerns, and two base set-up scenarios are discussed. There are many variables as well as many unknowns to be reckoned with before people set foot on the red planet.

Reproductive Decision-Making in MMR Mutation Carriers After Results Disclosure: Impact of Psychological Status in Childbearing Options.

PubMed

Duffour, Jacqueline; Combes, Audrey; Crapez, Evelyne; Boissière-Michot, Florence; Bibeau, Frédéric; Senesse, Pierre; Ychou, Marc; Courraud, Julie; de Forges, Hélène; Roca, Lise

2016-06-01

Reproductive techniques such as prenatal diagnosis (PND) or preimplantation genetic diagnosis (PGD), although debated, are legally forbidden in France in case of Lynch syndrome. The preference of mutation carriers about their reproductive options is not systematically considered in France. We aimed to prospectively assess the reproductive preferences of mismatch repair mutation carriers consulting in our institution (2003-2010, n = 100). We also considered the short- and long-term post-disclosure psychological impact using the Impact of Events Scale-Revised questionnaire to measure the prevalence of posttraumatic stress disorder (PTSD) in those patients. Complete data were obtained for 34 respondents (17 males, 17 females, median age of 33.5 years [22-59]). Seventeen respondents (57 %) preferred spontaneous natural conception versus 28 % and 35 % choosing PND and PGD, respectively. At results disclosure, respondents mainly explained their distress by fear of premature death (43 %) and transmitting mutated genes (42 %). One year later, this last fear remained predominant in 55 % of subjects. None of the main socio-demographical, psychological or medical variables (including fear of transmitting mutations) was significantly associated with the reproductive preferences. Results disclosure had a real and time-decreasing psychological impact on mutation carriers. Reproductive techniques, expected to decrease the hereditary risk, were not significantly preferred to natural conception.

The coastal use structure within the coastal system. A sustainable development-consistent approach

NASA Astrophysics Data System (ADS)

Vallega, A.

1996-01-01

To contribute to the development of methodological approaches to coastal area management consistent with the sustainable development concept and guidelines provided by UNCED Agenda 21, Chapter 17, first the classifications of coastal uses provided by literature and those adopted by coastal management programmes are presented and discussed. Moving from this basis and reasoning in terms of general system-sustained approach the following concepts and methodological issues are considered: a goal-oriented concept of coastal use; the sustainable development-grounded coastal use framework and the role of discriminants through which it is conceived and described; the relationships between coastal uses; in particular, conflicting relationships focusing attention on conflicts between decision-making centres, as well as users, motivations and tractability of uses; the relationships between coastal uses and the ecosystem; the basic options for sustainability-consistent coastal use development.

Techno-economic projections for advanced small solar thermal electric power plants to years 1990-2000

NASA Technical Reports Server (NTRS)

Fujita, T.; Manvi, R.; Roschke, E. J.; El-Gabalawi, N.; Herrera, G.; Kuo, T. J.; Chen, K. H.

1979-01-01

Advanced technologies applicable to solar thermal electric power systems in the 1990-200 time-frame are delineated for power applications that fulfill a wide spectrum of small power needs with primary emphasis on power ratings less than 10MWe. Projections of power system characteristics (energy and capital costs as a function of capacity factor) are made based on development of identified promising technologies and are used as the basis for comparing technology development options and combinations of these options to determine developmental directions offering potential for significant improvements. Stirling engines, Brayton/Rankine combined cycles and storage/transport concepts encompassing liquid metals, and reversible-reaction chemical systems are considered for two-axis tracking systems such as the central receiver or power tower concept and distributed parabolic dish receivers which can provide efficient low-cost solar energy collection while achieving high temperatures for efficient energy conversion. Pursuit of advanced technology across a broad front can result in post-1985 solar thermal systems having the potential of approaching the goal of competitiveness with conventional power systems.

Investing in deliberation: a definition and classification of decision support interventions for people facing difficult health decisions.

PubMed

Elwyn, Glyn; Frosch, Dominick; Volandes, Angelo E; Edwards, Adrian; Montori, Victor M

2010-01-01

This article provides an analysis of 'decision aids', interventions to support patients facing tough decisions. Interest has increased since the concept of shared decision making has become widely considered to be a means of achieving desirable clinical outcomes. We consider the aims of these interventions and examine assumptions about their use. We propose three categories, interventions that are used in face-to-face encounters, those designed for use outside clinical encounters and those which are mediated, using telephone or other communication media. We propose the following definition: decision support interventions help people think about choices they face; they describe where and why choice exists; they provide information about options, including, where reasonable, the option of taking no action. These interventions help people to deliberate, independently or in collaboration with others, about options, by considering relevantattributes; they support people to forecast how they might feel about short, intermediate and long-term outcomes which have relevant consequences, in ways which help the process of constructing preferences and eventual decision making, appropriate to their individual situation. Although quality standards have been published for these interventions, we are also cautious about premature closure and consider that the need for short versions for use inside clinical encounters and long versions for external use requires further research. More work is also needed on the use of narrative formats and the translation of theory into practical designs. The interest in decision support interventions for patients heralds a transformation in clinical practice although many important areas remain unresolved.

Coupling Adaptation Tipping Points and Engineering Options: New Insights for Resilient Water Infrastructure Replacement Planning

NASA Astrophysics Data System (ADS)

Smet, K.; de Neufville, R.; van der Vlist, M.

2017-12-01

This work presents an innovative approach for replacement planning for aging water infrastructure given uncertain future conditions. We draw upon two existing methodologies to develop an integrated long-term replacement planning framework. We first expand the concept of Adaptation Tipping Points to generate long-term planning timelines that incorporate drivers of investment related to both internal structural processes as well as changes in external operating conditions. Then, we use Engineering Options to explore different actions taken at key moments in this timeline. Contrasting to the traditionally more static approach to infrastructure design, designing the next generation of infrastructure so it can be changed incrementally is a promising method to safeguard current investments given future uncertainty. This up-front inclusion of structural options in the system actively facilitates future adaptation, transforming uncertainty management in infrastructure planning from reactive to more proactive. A two-part model underpins this approach. A simulation model generates diverse future conditions, allowing development of timelines of intervention moments in the structure's life. This feeds into an economic model, evaluating the lifetime performance of different replacement strategies, making explicit the value of different designs and their flexibility. A proof of concept study demonstrates this approach for a pumping station. The strategic planning timelines for this structure demonstrate that moments when capital interventions become necessary due to reduced functionality from structural degradation or changed operating conditions are widely spread over the structure's life. The disparate timing of these necessary interventions supports an incremental, adaptive mindset when considering end-of-life and replacement decisions. The analysis then explores different replacement decisions, varying the size and specific options included in the proposed new structure. Results show that incremental adaptive designs and incorporating options can improve economic performance, as compared to traditional, "build it once & build it big" designs. The benefit from incorporating flexibility varies with structural functionality, future conditions and the specific options examined.

Toward a gender-sensitive assisted reproduction policy.

PubMed

Donchin, Anne

2009-01-01

The recent case of the UK woman who lost her legal struggle to be impregnated with her own frozen embryos, raises critical issues about the meaning of reproductive autonomy and the scope of regulatory practices. I revisit this case within the context of contemporary debate about the moral and legal dimensions of assisted reproduction. I argue that the gender neutral context that frames discussion of regulatory practices is unjust unless it gives appropriate consideration to the different positions women and men occupy in relation to reproductive processes and their options for autonomous choice. First, I consider relevant legal rulings, media debate, and scholarly commentary. Then I discuss the concept of reproductive autonomy imbedded in this debate. I argue that this concept conflates informed consent and reproductive autonomy, thereby providing an excessively narrow reading of autonomy that fails to give due regard to relations among individuals or the social, political and economic environment that shapes their options. I contrast this notion of autonomy with feminist formulations that seek to preserve respect for the agency of individuals without severing them from the conditions of their embodiment, their surrounding social relationships, or the political contexts that shape their options. Taking these considerations into account I weigh the advantages of regulation over the commercial market arrangement that prevails in some countries and suggest general guidelines for a regulatory policy that would more equitably resolve conflicting claims to reproductive autonomy.

A Method for Aircraft Concept Selection Using Multicriteria Interactive Genetic Algorithms

NASA Technical Reports Server (NTRS)

Buonanno, Michael; Mavris, Dimitri

2005-01-01

The problem of aircraft concept selection has become increasingly difficult in recent years as a result of a change from performance as the primary evaluation criteria of aircraft concepts to the current situation in which environmental effects, economics, and aesthetics must also be evaluated and considered in the earliest stages of the decision-making process. This has prompted a shift from design using historical data regression techniques for metric prediction to the use of physics-based analysis tools that are capable of analyzing designs outside of the historical database. The use of optimization methods with these physics-based tools, however, has proven difficult because of the tendency of optimizers to exploit assumptions present in the models and drive the design towards a solution which, while promising to the computer, may be infeasible due to factors not considered by the computer codes. In addition to this difficulty, the number of discrete options available at this stage may be unmanageable due to the combinatorial nature of the concept selection problem, leading the analyst to arbitrarily choose a sub-optimum baseline vehicle. These concept decisions such as the type of control surface scheme to use, though extremely important, are frequently made without sufficient understanding of their impact on the important system metrics because of a lack of computational resources or analysis tools. This paper describes a hybrid subjective/quantitative optimization method and its application to the concept selection of a Small Supersonic Transport. The method uses Genetic Algorithms to operate on a population of designs and promote improvement by varying more than sixty parameters governing the vehicle geometry, mission, and requirements. In addition to using computer codes for evaluation of quantitative criteria such as gross weight, expert input is also considered to account for criteria such as aeroelasticity or manufacturability which may be impossible or too computationally expensive to consider explicitly in the analysis. Results indicate that concepts resulting from the use of this method represent designs which are promising to both the computer and the analyst, and that a mapping between concepts and requirements that would not otherwise be apparent is revealed.

Grid-independent residential power systems

NASA Astrophysics Data System (ADS)

Nelson, Robert E.

1996-02-01

A self-powered, gas-fired, warm air furnace is evaluated as a candidate for the autonomous generation of electrical power. A popular, commercial residential furnace is analyzed for electrical power requirements. Available energy conversion concepts are considered for this application, and the thermophotovoltaic (TPV) option is selected due to reliability and cost. The design and the internal components peculiar to the TPV converter will be covered. Operating results, including NOx emission, will be summarized. This work was sponsored by the Basic Research Group, Gas Research Institute, Chicago, IL.

Choroidal neovascular membrane.

PubMed

Bhatt, N S; Diamond, J G; Jalali, S; Das, T

1998-06-01

Choroidal neovascular membrane in the macular area is one of the leading causes of severe visual loss. Usually a manifestation in elderly population, it is often associated with age-related macular degeneration. The current mainstay of management is early diagnosis, usually by fundus examination, aided by angiography and photocoagulation in selected cases. Various other modalities of treatment including surgery are being considered as alternate options, but with limited success. The purpose of this review is to briefly outline the current concepts and the management strategy from a clinician's viewpoint.

Space Station crew safety alternatives study. Volume 4: Appendices

NASA Technical Reports Server (NTRS)

Peercy, R. L., Jr.; Raasch, R. F.; Rockoff, L. A.

1985-01-01

The scope of this study considered the first 15 years of accumulated space station concepts for Initial Operational Capability (10C) during the early 1990's. Twenty-five threats to the space station are identified and selected threats addressed as impacting safety criteria, escape and rescue, and human factors safety concerns. Of the 25 threats identified, eight are discussed including strategy options for threat control: fire, biological or toxic contamination, injury/illness, explosion, loss of pressurization, radiation, meteoroid penetration and debris.

The Department of Defense’s Use of Private Security Contractors in Iraq and Afghanistan: Background, Analysis, and Options for Congress

DTIC Science & Technology

2010-01-19

they are generally considered to be support personnel under Title X. 34 A 2007 study published by the Combat Studies Institute determined the tooth...for which it contracts with private companies in military operations. Congress has generally accepted the concept of using unarmed contractors to...installations and U.S. embassies and consulates in a number of countries where stability generally is not an issue. 3 According to one report, “Not

The Black-Scholes option pricing problem in mathematical finance: generalization and extensions for a large class of stochastic processes

NASA Astrophysics Data System (ADS)

Bouchaud, Jean-Philippe; Sornette, Didier

1994-06-01

The ability to price risks and devise optimal investment strategies in thé présence of an uncertain "random" market is thé cornerstone of modern finance theory. We first consider thé simplest such problem of a so-called "European call option" initially solved by Black and Scholes using Ito stochastic calculus for markets modelled by a log-Brownien stochastic process. A simple and powerful formalism is presented which allows us to generalize thé analysis to a large class of stochastic processes, such as ARCH, jump or Lévy processes. We also address thé case of correlated Gaussian processes, which is shown to be a good description of three différent market indices (MATIF, CAC40, FTSE100). Our main result is thé introduction of thé concept of an optimal strategy in the sense of (functional) minimization of the risk with respect to the portfolio. If the risk may be made to vanish for particular continuous uncorrelated 'quasiGaussian' stochastic processes (including Black and Scholes model), this is no longer the case for more general stochastic processes. The value of the residual risk is obtained and suggests the concept of risk-corrected option prices. In the presence of very large deviations such as in Lévy processes, new criteria for rational fixing of the option prices are discussed. We also apply our method to other types of options, `Asian', `American', and discuss new possibilities (`doubledecker'...). The inclusion of transaction costs leads to the appearance of a natural characteristic trading time scale. L'aptitude à quantifier le coût du risque et à définir une stratégie optimale de gestion de portefeuille dans un marché aléatoire constitue la base de la théorie moderne de la finance. Nous considérons d'abord le problème le plus simple de ce type, à savoir celui de l'option d'achat `européenne', qui a été résolu par Black et Scholes à l'aide du calcul stochastique d'Ito appliqué aux marchés modélisés par un processus Log-Brownien. Nous présentons un formalisme simple et puissant qui permet de généraliser l'analyse à une grande classe de processus stochastiques, tels que les processus ARCH, de Lévy et ceux à sauts. Nous étudions également le cas des processus Gaussiens corrélés, dont nous montrons qu'ils donnent une bonne description de trois indices boursiers (MATIF, CAC40, FTSE100). Notre résultat principal consiste en l'introduction du concept de stratégie optimale dans le sens d'une minimisation (fonctionnelle) du risque en fonction du portefeuille d'actions. Si le risque peut être annulé pour les processus `quasi-Gaussien' non-corrélés, dont le modèle de Black et Scholes est un exemple, cela n'est plus vrai dans le cas général, le risque résiduel permettant de proposer des coûts d'options "corrigés". En présence de très grandes fluctuations du marché telles que décrites par les processus de Lévy, de nouveaux critères pour fixer rationnellement le prix des options sont nécessaires et sont discutés. Nous appliquons notre méthode à d'autres types d'options, telles que `asiatiques', `américaines', et à de nouvelles options que nous introduisons comme les `options à deux étages'... L'inclusion des frais de transaction dans le formalisme conduit à l'introduction naturelle d'un temps caractéristique de transaction.

Options for the Future of the US National Strong-Motion Program

USGS Publications Warehouse

,

1997-01-01

This report constitutes the requested 'Options Document'. This report considers three options. Option I assumes a constant level of financial support for Operating Expenses (OE) with not additional personnel support. Option II assumes a slight increase in OE support of $150K for FY 99 and beyond. Option III considers the role that a NSMP must play if the nation's urgent need to record the main earthquake at locations of significance for society is to be met. Two parts of Option III are considered. The first part of this option, termed Option III A, considers the role that strong-motion recording in and near man-made structures must play if a near-real time hazard initiative is to be implemented in the United States; The second part of Option III; termed Option III B, considers the scope of a NSMP needed to address society's needs to record the main earthquake in locations of significance for future public earthquake safety.

Alternative disposal options for transuranic waste

DOE Office of Scientific and Technical Information (OSTI.GOV)

Loomis, G.G.

1994-12-31

Three alternative concepts are proposed for the final disposal of stored and retrieved buried transuranic waste. These proposed options answer criticisms of the existing U.S. Department of Energy strategy of directly disposing of stored transuranic waste in deep, geological salt formations at the Waste Isolation Pilot Plant (WIPP) in Carlsbad, New Mexico. The first option involves enhanced stabilization of stored waste by thermal treatment followed by convoy transportation and internment in the existing WIPP facility. This concept could also be extended to retrieved buried waste with proper permitting. The second option involves in-state, in situ internment using an encapsulating lensmore » around the waste. This concept applies only to previously buried transuranic waste. The third option involves sending stored and retrieved waste to the Nevada Test Site and configuring the waste around a thermonuclear device from the U.S. or Russian arsenal in a specially designed underground chamber. The thermonuclear explosion would transmute plutonium and disassociate hazardous materials while entombing the waste in a national sacrifice area.« less

Concept of Operations for RCO SPO

NASA Technical Reports Server (NTRS)

Matessa, Michael; Strybel, Thomas; Vu, Kim; Battiste, Vernol; Schnell, Thomas

2017-01-01

Reduced crew operations (RCO) refers to the reduction of crew members flying long-haul or military operations with more than one pilot onboard. Single pilot operations (SPO) refers to flying a commercial transport aircraft with only one pilot on board the aircraft, assisted by advanced onboard automation andor ground operators providing piloting support services. Properly implemented, RCO/SPO could provide operating cost savings while maintaining a level of safety no less than conventional two-pilot commercial operations. A concept of operations (ConOps) for any paradigm describes the characteristics of its various components and their integration in a multi-dimensional design space. This paper presents key options for humanautomation function allocation being considered by NASA in its ongoing development of RCO/SPO ConOps.

A Small Fission Power System for NASA Planetary Science Missions

NASA Technical Reports Server (NTRS)

Mason, Lee; Casani, John; Elliott, John; Fleurial, Jean-Pierre; MacPherson, Duncan; Nesmith, William; Houts, Michael; Bechtel, Ryan; Werner, James; Kapernick, Rick;

Martian Meteorological Lander

NASA Astrophysics Data System (ADS)

Vorontsov, V.; Pichkhadze, K.; Polyakov, A.

2002-01-01

Martian meteorological lander (MML) is dedicated for landing onto the Mars surface with the purpose to carry on the monitoring of Mars atmosphere condition at a landing point during one Martian year. MML is supposed to become the basic element of a global net of meteorological mini stations and will permit to observe the dynamics of Martian atmosphere parameters changes during a long time duration. The main scientific tasks of MML are as follows: -study of vertical structure of Mars atmosphere during MML descending; -meteorological observations on Mars surface during one Martian year. One of the essential factor influencing to the lander design is descent trajectory design. During the preliminary phase of development five (5) options of MML were considered. In our opinion, these variants provide the accomplishment of the above-mentioned tasks with a high effectiveness. Joined into the first group, variants with parachute system and with Inflatable Air Brakes+Inflatable Airbag are similar in arranging of pre-landing braking stage and completely analogous in landing by means of airbags. The usage of additional Inflatable Braking Unit (IBU) in the second variant does not affect the procedure of braking - decreasing of velocity by the moment of touching the surface due to decreasing of ballistic parameter Px. A distinctive feature of MML development variants of other three concepts is the presence of Inflatable Braking Unit (IBU) in their configurations (IBU is rigidly joined with landing module up to the moment of its touching the surface). Besides, in variant with the tore-shaped IBU it acts as a shock- absorbing unit. In two options, Inflatable Braking Shock-Absorbing Unit (IBSAU) (or IBU) releases the surface module after its landing at the moment of IBSAU (or IBU) elastic recoil. Variants of this concept are equal in terms of mass (approximately 15 kg). For variants of concepts with IBU the landing velocity is up to50-70 m/s. Stations of last three options are much more reliable in comparison with MML of first and second options because their functional diagram is realized by operation of 3-4 (instead of 8-10 for MML of first and second concepts) executive devices. A distinctive moment for MML of last three concepts , namely for variants 3 and 5, is the final stage of landing stipulated by penetration of forebody into the soil. Such a profile of landing was taken into account during the development of one of the landing vehicles for the "MARS-96" SC. This will permit to implement simple technical decisions for putting the meteorological complex into operation and to carry out its further operations on the surface. After comparative analysis of 5 concepts for the more detailed development concepts with parachute system and with IBU and penetration unit have been chosen as most prospective. However, finally, on the next step the new modification of the lander (hybrid version of third and fifth option with inflatable braking device and penetrating unit) has been proposed and chosen for the next step of development. The several small stations should be transported to Mars in frameworks of Scout Mars mission, or Phobos Sample Return mission as piggyback payload.

Adaptation of the Electra Radio to Support Multiple Receive Channels

NASA Technical Reports Server (NTRS)

Satorius, Edgar H.; Shah, Biren N.; Bruvold, Kristoffer N.; Bell, David J.

2011-01-01

Proposed future Mars missions plan communication between multiple assets (rovers). This paper presents the results of a study carried out to assess the potential adaptation of the Electra radio to a multi-channel transceiver. The basic concept is a Frequency Division multiplexing (FDM) communications scheme wherein different receiver architectures are examined. Options considered include: (1) multiple IF slices, A/D and FPGAs each programmed with an Electra baseband modem; (2) common IF but multiple A/Ds and FPGAs and (3) common IF, single A/D and single or multiple FPGAs programmed to accommodate the FDM signals. These options represent the usual tradeoff between analog and digital complexity. Given the space application, a common IF is preferable; however, multiple users present dynamic range challenges (e.g., near-far constraints) that would favor multiple IF slices (Option 1). Vice versa, with a common IF and multiple A/Ds (Option 2), individual AGC control of the A/Ds would be an important consideration. Option 3 would require a common AGC control strategy and would entail multiple digital down conversion paths within the FPGA. In this paper, both FDM parameters as well as the different Electra design options will be examined. In particular, signal channel spacing as a function of user data rates and transmit powers will be evaluated. In addition, tradeoffs between the different Electra design options will be presented with the ultimate goal of defining an augmented Electra radio architecture for potential future missions.

Engaging Adolescents to Inform the Development of a Mobile Gaming App to Incentivize Physical Activity

PubMed Central

Dibble, Marguerite

2017-01-01

Background Involving youth in the development of a mobile game designed to increase physical activity may increase relevancy and adoption. Objective To share the development process used to create a gaming app aimed at incentivizing physical activity in high school students. Methods Five focus groups were conducted with high school students (N=50) to understand gaming behaviors. A subset of students from the focus groups chose to complete a Web-based survey (N=10). Four different versions of gaming artwork and concept design based on student input were pilot tested (N=35), and group consensus building determined the direction of the game. The 4 game versions differed in their artwork style and gaming concept with some requiring competition versus cooperation, or being more individual versus team based. Group consensus building meant that all artwork and game concept options were displayed at the front of a classroom. Students could then vote for their top artwork and concept choices by putting stickers on the top 1 or 2 artwork and concept options that they liked best. Once all votes were cast, investigators discussed the voting results with students, and brainstormed ways to incorporate popular aspects of the 3 “losing” artwork and game concepts into the winning ideas. Results Focus group transcripts were analyzed for common themes. Artwork and gaming concept-voting data was tallied at the time of voting to share with students in real time. Focus groups and survey results revealed important themes for a successful gaming app: (1) competition, (2) balanced in-game rewards, (3) accessibility, and (4) aesthetic features. Consensus voting indicated the popularity of a collaborative competitive content design (35/66, 53%) and playful art (27/71, 38%). Conclusions To ensure saliency and effectiveness of game-based physical activity interventions, youth need to be included in design and implementation. Furthermore, the unique preferences and social constructs of high school students need to be considered during intervention development. PMID:28851676

Trajectory Design of the Lunar Impactor Mission Concept

NASA Technical Reports Server (NTRS)

Chung, Min-Kun J.; McElrath, Timothy P.; Roncoli, Ralph B.

2006-01-01

The National Aeronautics and Space Administration (NASA) solicited proposals in 2006 for an opportunity to include a small secondary payload with the launch of the Lunar Reconnaissance Orbiter (LRO) scheduled for October 2008. The cost cap of the proposal was between $50 and $80M, and the mass cap was 1,000 kilograms. JPL proposed a Lunar Impactor (LI) concept for this solicitation. The mission objective of LI was to impact the permanently shadowed region of a South polar crater ultimately to detect the presence of water. The detection of water ice would prove to be an important factor on future lunar exploration. NASA Ames Research Center also proposed a similar concept, the Lunar Crater observation and Sensing Satellite (LCROSS), which was selected by NASA for the mission. However, in this paper, the trajectory design of the LI proposed by JPL is considered. Since the LI spacecraft was to be launched on the LRO launch vehicle as a secondary payload, its initial trajectory must be diverted at some later time from the LRO trans-lunar trajectory for the subsequent impact. Several such trajectories have been considered, where each trajectory option fields some specific values for the mission parameters. The mission parameters include the availability of LRO instruments at the time of impact for the observation by LRO, the mission duration, the impact velocity, the impact angle, etc. It is possible for the LI to be deflected with a relatively low delta-V to impact a South polar crater at a reasonable impact velocity and impact angle directly with no delay. However, the instruments on-board LRO may not be ready for observation. Thus, several delayed trajectory options have been considered further. The lunar phase at the time of impact may also play an important factor for observation, especially from Earth. Several lunar flyby trajectory maneuvers have been identified to arrive at the Moon for impact at the desired lunar phase. By using a combination of these successive lunar flyby maneuvers, the impact lunar phase may be adjusted to the desired location. A few such trajectories have been suggested. Also, some attempts have been made to maximize the impact velocity by converting the impact trajectory into a retrograde orbit with respect to Earth. Since these types of trajectories take advantage of the Sun-Earth three-body region to minimize the delta-V, the mission duration is relatively long. A few such trajectories are suggested. Also, an attempt has been made to adjust the lunar impact within a desired time period for the optimum Earth observation for the above trajectories. The mission parameters resulting from each trajectory option above are considered and weighed against the cost and robustness of the mission in a brief summary.

The 25 kW power module evolution study. Part 3: Conceptual designs for power module evolution. Volume 4: Design analyses

NASA Technical Reports Server (NTRS)

1979-01-01

Topics covered include growth options evaluation, mass properties, attitude control and structural dynamics, contamination evaluation, berthing concepts, orbit reboost options and growth kit concepts. Systems support elements and space support equipment are reviewed with emphasis on power module operations and technology planning.

Preliminary Assessment of Thrust Augmentation of NEP Based Missions

NASA Technical Reports Server (NTRS)

Chew, Gilbert; Pelaccio, Dennis G.; Chiroux, Robert; Pervan, Sherry; Rauwolf, Gerald A.; White, Charles

2005-01-01

Science Applications International Corporation (SAIC), with support from NASA Marshall Space Flight Center, has conducted a preliminary study to compare options for augmenting the thrust of a conventional nuclear electric propulsion (NEP) system. These options include a novel nuclear propulsion system concept known as Hybrid Indirect Nuclear Propulsion (HINP) and conventional chemical propulsion. The utility and technical feasibility of the HINP concept are assessed, and features and potential of this new in-space propulsion system concept are identified. As part of the study, SAIC developed top-level design tools to model the size and performance of an HINP system, as well as for several chemical propulsion options, including liquid and gelled propellants. A mission trade study was performed to compare a representative HINP system with chemical propulsion options for thrust augmentation of NEP systems for a mission to Saturn's moon Titan. Details pertaining to the approach, features, initial demonstration results for HINP model development, and the mission trade study are presented. Key technology and design issues associated with the HINP concept and future work recommendations are also identified.

Eco-efficiency improvements in industrial water-service systems: assessing options with stakeholders.

PubMed

Levidow, Les; Lindgaard-Jørgensen, Palle; Nilsson, Asa; Skenhall, Sara Alongi; Assimacopoulos, Dionysis

2014-01-01

The well-known eco-efficiency concept helps to assess the economic value and resource burdens of potential improvements by comparison with the baseline situation. But eco-efficiency assessments have generally focused on a specific site, while neglecting wider effects, for example, through interactions between water users and wastewater treatment (WWT) providers. To address the methodological gap, the EcoWater project has developed a method and online tools for meso-level analysis of the entire water-service value chain. This study investigated improvement options in two large manufacturing companies which have significant potential for eco-efficiency gains. They have been considering investment in extra processes which can lower resource burdens from inputs and wastewater, as well as internalising WWT processes. In developing its methodology, the EcoWater project obtained the necessary information from many agents, involved them in the meso-level assessment and facilitated their discussion on alternative options. Prior discussions with stakeholders stimulated their attendance at a workshop to discuss a comparative eco-efficiency assessment for whole-system improvement. Stakeholders expressed interest in jointly extending the EcoWater method to more options and in discussing investment strategies. In such ways, optimal solutions will depend on stakeholders overcoming fragmentation by sharing responsibility and knowledge.

A Comparison of Fission Power System Options for Lunar and Mars Surface Applications

NASA Technical Reports Server (NTRS)

Mason, Lee S.

2006-01-01

This paper presents a comparison of reactor and power conversion design options for 50 kWe class lunar and Mars surface power applications with scaling from 25 to 200 kWe. Design concepts and integration approaches are provided for three reactor-converter combinations: gas-cooled Brayton, liquid-metal Stirling, and liquid-metal thermoelectric. The study examines the mass and performance of low temperature, stainless steel based reactors and higher temperature refractory reactors. The preferred system implementation approach uses crew-assisted assembly and in-situ radiation shielding via installation of the reactor in an excavated hole. As an alternative, self-deployable system concepts that use earth-delivered, on-board radiation shielding are evaluated. The analyses indicate that among the 50 kWe stainless steel reactor options, the liquid-metal Stirling system provides the lowest mass at about 5300 kg followed by the gas-cooled Brayton at 5700 kg and the liquid-metal thermoelectric at 8400 kg. The use of a higher temperature, refractory reactor favors the gas-cooled Brayton option with a system mass of about 4200 kg as compared to the Stirling and thermoelectric options at 4700 and 5600 kg, respectively. The self-deployed concepts with on-board shielding result in a factor of two system mass increase as compared to the in-situ shielded concepts.

Gut microbiota role in irritable bowel syndrome: New therapeutic strategies

PubMed Central

Distrutti, Eleonora; Monaldi, Lorenzo; Ricci, Patrizia; Fiorucci, Stefano

2016-01-01

In the last decade the impressive expansion of our knowledge of the vast microbial community that resides in the human intestine, the gut microbiota, has provided support to the concept that a disturbed intestinal ecology might promote development and maintenance of symptoms in irritable bowel syndrome (IBS). As a correlate, manipulation of gut microbiota represents a new strategy for the treatment of this multifactorial disease. A number of attempts have been made to modulate the gut bacterial composition, following the idea that expansion of bacterial species considered as beneficial (Lactobacilli and Bifidobacteria) associated with the reduction of those considered harmful (Clostridium, Escherichia coli, Salmonella, Shigella and Pseudomonas) should attenuate IBS symptoms. In this conceptual framework, probiotics appear an attractive option in terms of both efficacy and safety, while prebiotics, synbiotics and antibiotics still need confirmation. Fecal transplant is an old treatment translated from the cure of intestinal infective pathologies that has recently gained a new life as therapeutic option for those patients with a disturbed gut ecosystem, but data on IBS are scanty and randomized, placebo-controlled studies are required. PMID:26900286

Treatment Satisfaction in Systemic Lupus Erythematosus: Development of a Patient-Reported Outcome Measure.

PubMed

Mathias, Susan D; Berry, Pamela; Pascoe, Katie; de Vries, Jane; Askanase, Anca D; Colwell, Hilary H; Chang, David J

2017-03-01

The aim of this study was to develop a patient-reported outcome measure specific for systemic lupus erythematosus (SLE) to assess patient satisfaction with treatment, treatment options, and medical care. Patients with SLE were recruited from four US rheumatology practices. Concept elicitation interviews identified aspects that patients considered important and relevant regarding satisfaction with treatment and medical care. Concept elicitation interviews and clinical input were used to draft the Lupus Satisfaction Questionnaire (LSQ). A second cohort of patients with SLE participated in combined concept elicitation/cognitive debriefing interviews, after which the LSQ was revised. Fourteen patients completed concept elicitation interviews: 93% were female, 57% were white, and 85% had moderate/severe SLE. Current treatments included hydroxychloroquine (93%), steroids (79%), and belimumab (57%), and 43% were biologic naive. Patients were generally satisfied with their treatment and medical care; however, they were dissatisfied with treatment adverse effects and the number of available treatment options. Cognitive debriefing interviews (n = 8) demonstrated that the LSQ was comprehensive, clear, and relevant; therefore, only minor revisions were made to the questionnaire. The LSQ assesses satisfaction with current SLE treatments (25 items), medical care (11 items), and insurance coverage (3 items). The draft LSQ was evaluated in 195 adults with SLE. Fifty-eight percent of patients reported that they were "somewhat satisfied" with their SLE treatment. The LSQ has been developed to assess treatment satisfaction among patients with SLE. Following further testing to support its validity and reliability, it will provide a useful tool to facilitate assessment of satisfaction with treatments for SLE and help inform treatment decisions.

Selection of Lockheed Martin's Preferred TSTO Configurations for the Space Launch Initiative

NASA Technical Reports Server (NTRS)

Hopkins, Joshua B.

2002-01-01

Lockheed Martin is developing concepts for safe, affordable Two Stage to Orbit (TSTO) reusable launch vehicles as part of NASA s Space Launch Initiaiive. This paper discusses the options considered for the design of the TSTO, the impact of each of these options on the vehicle configuration, the criteria used for selection of preferred configurations, and the results of the selection process. More than twenty configurations were developed in detail in order to compare optioiis such as propellant choice, serial vs. parallel burn sequence, use of propellant crossfeed between stages, bimese or optimized stage designs, and high or low staging velocities. Each configuration was analyzed not only for performance and sizing, but also for cost and reliability. The study concluded that kerosene was the superior fuel for first stages, and that bimese vehicles were not attractive.

Report of the NASA lunar energy enterprise case study task force

NASA Technical Reports Server (NTRS)

1989-01-01

The Lunar Energy Enterprise Cast Study Task Force was formed to determine the economic viability and commercial business potential of mining and extracting He-3 from the lunar soil for use in earth-based fusion reactors. In addition, the Solar Power Satellite (SPS) and the Lunar Power Station (LPS) were also evaluated because they involve the use of lunar materials and could provide energy for lunar-based activities. The Task Force considered: (1) the legal and liability aspects of the space energy projects; (2) the long-range terrestrial energy needs and options; (3) the technical maturity of the three space energy projects; and (4) their commercial potential. The use of electricity is expected to increase, but emerging environmental concerns and resource availability suggest changes for the national energy policy. All three options have the potential to provide a nearly inexhaustible, clean source of electricity for the U.S. and worldwide, without major adverse impacts on the Earth's environment. Assumption by industry of the total responsibility for these energy projects is not yet possible. Pursuit of these energy concepts requires the combined efforts of government and industry. The report identifies key steps necessary for the development of these concepts and an evolving industrial role.

Space transfer concepts and analysis for exploration missions. Implementation plan and element description document (draft final). Volume 4: Solar electric propulsion vehicle

NASA Technical Reports Server (NTRS)

1991-01-01

This document presents the solar electric propulsion (SEP) concept design developed as part of the Space Transfer Concepts and Analysis for Exploration Missions (STCAEM) study. The evolution of the SEP concept is described along with the requirements, guidelines and assumptions for the design. Operating modes and options are defined and a systems description of the vehicle is presented. Artificial gravity configuration options and space and ground support systems are discussed. Finally, an implementation plan is presented which addresses technology needs, schedules, facilities, and costs.

Space transfer concepts and analysis for exploration missions. Implementation plan and element description document (draft final). Volume 2: Cryo/aerobrake vehicle

NASA Technical Reports Server (NTRS)

1991-01-01

The cryogenic/aerobrake (CAB) and the cryogenic all-propulsive (CAP) concept designs developed in support of the Space Transfer Concepts and Analysis for Exploration Missions (STCAEM) study are presented. The evolution of the CAB and CAP concepts is described along with the requirements, guidelines and assumptions for the designs. Operating modes and options are defined and systems descriptions of the vehicles are presented. Artificial gravity configuration options and space and ground support systems are discussed. Finally, an implementation plan is presented which addresses technology needs, schedules, facilities, and costs.

Space transfer concepts and analysis for exploration missions. Implementation plan and element description document (draft final). Volume 5: Nuclear electric propulsion vehicle

NASA Technical Reports Server (NTRS)

1991-01-01

The nuclear electric propulsion (NEP) concept design developed in support of the Space Transfer Concepts and Analysis for Exploration Missions (STCAEM) study is presented. The evolution of the NEP concept is described along with the requirements, guidelines, and assumptions for the design. Operating modes and options are defined and a systems description of the vehicle is presented. Artificial gravity configuration options and space and ground support systems are discussed. Finally, an implementation plan is presented which addresses technology needs, schedules, facilities and costs.

Space transfer concepts and analysis for exploration missions. Implementation plan and element description document (draft final). Volume 3: Nuclear thermal rocket vehicle

NASA Technical Reports Server (NTRS)

1991-01-01

This document presents the nuclear thermal rocket (NTR) concept design developed in support of the Space Transfer Concepts and Analysis for Exploration Missions (STCAEM) study. The evolution of the NTR concept is described along with the requirements, guidelines and assumptions for the design. Operating modes and options are defined and a systems description of the vehicle is presented. Artificial gravity configuration options and space and ground support systems are discussed. Finally, an implementation plan is presented which addresses technology needs, schedules, facilities and costs.

Space Station redesign option A: Modular buildup concept

NASA Technical Reports Server (NTRS)

1993-01-01

In early 1993, President Clinton mandated that NASA look at lower cost alternatives to Space Station Freedom. He also established an independent advisory committee - the Blue Ribbon Panel - to review the redesign work and evaluate alternatives. Daniel Goldin, NASA Administrator, established a Station Redesign Team that began operating in late March from Crystal City, Virginia. NASA intercenter teams - one each at Marshall Space Flight Center, Johnson Space Center, and Langley Research Center provided engineering and other support. The results of the Option A study done at Marshall Space Flight Center are summarized. Two configurations (A-1 and A-2) are covered. Additional data is provided in the briefing package MSFC SRT-001, Final System Review to SRT-002, Space Station Option A Modular Buildup Concept, Volumes 1-5, Revision B, June 10, 1993. In June 1993, President Clinton decided to proceed with a modular concept consistent with Option A, and asked NASA to provide an Implementation Plan by September. All data from the Option A redesign activity was provided to NASA's Transition Team for use in developing the Implementation Plan.

Defense Health Care: Additional Analysis of Costs and Benefits of Potential Governance Structures Is Needed

DTIC Science & Technology

2012-09-01

options, (2) a business case analysis and strategy for implementing its shared services concept, and (3) more complete analyses of the options’ strengths...and weaknesses. DoD concurred with developing a business case analysis for its shared services concept. DoD did not concur with the other two

[Reproductive options for people living with HIV: 2013 guidelines from the French expert working group].

PubMed

Mandelbrot, L; Berrebi, A; Rouzioux, C; Partisani, M; Faucher, P; Tubiana, R; Matheron, S; Bujan, L; Morlat, P

2014-01-01

The desire for children is a legitimate aspiration that should be part of multidisciplinary care for all men, women or couples living with HIV. The use of effective antiretroviral therapy has revolutionized the prevention of sexual, as well as mother-to-child HIV transmission. When the HIV plasma viral load is undetectable on long-term antiretroviral therapy, the risk of mother-to-child transmission is <1% and the risk of heterosexual HIV transmission without condom use in a stable relationship is very low (estimated at less than 1/10,000) in the absence of inflammation of the genital tract. In a man with a long-term undetectable viral load, viral shedding in semen is uncommon, but may occur persistently or intermittently. The same appears true of viral shedding in the vaginal tract of women. Reproductive options are: natural conception, self-insemination when the woman is HIV-infected, assisted reproduction. Natural conception is now considered to be an acceptable option when the conditions are met, after exploring four aspects: (1) virological (viral load undetectable sustained for at least 6 months on therapy), (2) genital (absence of genital infections or lesions), (3) fertility (after appropriate evaluation) and (4) detecting the ovulation period to limit intercourse without condoms. Assisted reproduction has two objectives in the context of HIV, to allow the couple to conceive without abandoning condom use and/or to treat infertility. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Coordinating Demand-Side Efficiency Evaluation, Measurement and Verification Among Western States: Options for Documenting Energy and Non-Energy Impacts for the Power Sector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schiller, Steven R.; Schwartz, Lisa C.

Demand-side energy efficiency (efficiency) represents a low-cost opportunity to reduce electricity consumption and demand and provide a wide range of non-energy benefits, including avoiding air pollution. Efficiency-related energy and non-energy impacts are determined and documented by implementing evaluation, measurement and verification (EM&V) systems. This technical brief describes efficiency EM&V coordination strategies that Western states can consider taking on together, outlines EM&V-related products that might be appropriate for multistate coordination, and identifies some implications of coordination. Coordinating efficiency EM&V activities can save both time and costs for state agencies and stakeholders engaged in efficiency activities and can be particularly beneficial formore » multiple states served by the same utility. First, the brief summarizes basic information on efficiency, its myriad potential benefits and EM&V for assessing those benefits. Second, the brief introduces the concept of multistate EM&V coordination in the context of assessing such benefits, including achievement of state and federal goals to reduce air pollutants.1 Next, the brief presents three coordination strategy options for efficiency EM&V: information clearinghouse/exchange, EM&V product development, and a regional energy efficiency tracking system platform. The brief then describes five regional EM&V products that could be developed on a multistate basis: EM&V reporting formats, database of consistent deemed electricity savings values, glossary of definitions and concepts, efficiency EM&V methodologies, and EM&V professional standards or accreditation processes. Finally, the brief discusses options for next steps that Western states can take to consider multistate coordination on efficiency EM&V. Appendices provide background information on efficiency and EM&V, as well as definitions and suggested resources on the covered topics. This brief is intended to inform state public utility commissions, boards for public and consumer-owned utilities, state energy offices and air agencies, and other organizations involved in discussions about the use of efficiency EM&V.« less

Asteroid Redirect Crewed Mission Space Suit and EVA System Architecture Trade Study

NASA Technical Reports Server (NTRS)

Bowie, Jonathan T.; Blanco, Raul A.; Watson, Richard D.; Kelly, Cody; Buffington, Jesse; Sipila, Stephanie A.

2014-01-01

This paper discusses the Asteroid Redirect Crewed Mission (ARCM) space suit and Extravehicular Activity (EVA) architecture trade study and the current state of the work to mature the requirements and products to the mission concept review level. The mission requirements and the resulting concept of operations will be discussed. A historical context will be presented as to present the similarities and differences from previous NASA missions. That will set the stage for the trade study where all options for both pressure garment and life support were considered. The rationale for the architecture decisions will then be presented. Since the trade study did identity risks, the subsequent tests and analyses that mitigated the risks will be discussed. Lastly, the current state of the effort will be provided.

A study of space station needs, attributes, and architectural options, volume 2, technical. Book 2: Mission implementation concepts

NASA Technical Reports Server (NTRS)

1983-01-01

Space station systems characteristics and architecture are described. A manned space station operational analysis is performed to determine crew size, crew task complexity and time tables, and crew equipment to support the definition of systems and subsystems concepts. This analysis is used to select and evaluate the architectural options for development.

Marriageable Women: A Focus on Participants in a Community Healthy Marriage Program

PubMed Central

Manning, Wendy D.; Trella, Deanna; Lyons, Heidi; Toit, Nola Cora Du

2012-01-01

Although disadvantaged women are the targets of marriage programs, little attention has been paid to women's marriage constraints and their views of marriage. Drawing on an exchange framework and using qualitative data collected from single women participating in a marriage initiative, we introduce the concept of marriageable women—the notion that certain limitations may make women poor marriage partners. Like their male counterparts, we find women also possess qualities that are not considered assets in the marriage market, such as economic constraints, mental and physical health issues, substance use, multiple partner fertility, and gender distrust. We also consider how women participating in a marriage program frame their marriage options, whereas a few opt out of the marriage market altogether. PMID:23258947

Fixed-base flywheel storage systems for electric-utility applications: An assessment of economic viability and R and D priorities

NASA Astrophysics Data System (ADS)

Olszewski, M.; Steele, R. S.

1983-02-01

Electric utility side meter storage options were assessed for the daily 2 h peaking spike application. The storage options considered included compressed air, batteries, and flywheels. The potential role for flywheels in this application was assessed and research and development (R and D) priorities were established for fixed base flywheel systems. Results of the worth cost analysis indicate that where geologic conditions are favorable, compressed air energy storage (CAES) is a strong competitor against combustion turbines. Existing battery and flywheel systems rated about equal, both being, at best, marginally uncompetitive with turbines. Advanced batteries, if existing cost and performance goals are met, could be competitive with CAES. A three task R and D effort for flywheel development appears warranted. The first task, directed at reducing fabrication coss and increasing performance of a chopped fiber, F-glass, solid disk concept, could produce a competitive flywheel system.

United States planetary rover status: 1989

NASA Technical Reports Server (NTRS)

Pivirotto, Donna L. S.; Dias, William C.

1990-01-01

A spectrum of concepts for planetary rovers and rover missions, is covered. Rovers studied range from tiny micro rovers to large and highly automated vehicles capable of traveling hundreds of kilometers and performing complex tasks. Rover concepts are addressed both for the Moon and Mars, including a Lunar/Mars common rover capable of supporting either program with relatively small modifications. Mission requirements considered include both Science and Human Exploration. Studies include a range of autonomy in rovers, from interactive teleoperated systems to those requiring and onboard System Executive making very high level decisions. Both high and low technology rover options are addressed. Subsystems are described for a representative selection of these rovers, including: Mobility, Sample Acquisition, Science, Vehicle Control, Thermal Control, Local Navigation, Computation and Communications. System descriptions of rover concepts include diagrams, technology levels, system characteristics, and performance measurement in terms of distance covered, samples collected, and area surveyed for specific representative missions. Rover development schedules and costs are addressed for Lunar and Mars exploration initiatives.

Near-Nash targeting strategies for heterogeneous teams of autonomous combat vehicles

NASA Astrophysics Data System (ADS)

Galati, David G.; Simaan, Marwan A.

2008-04-01

Military strategists are currently seeking methodologies to control large numbers of autonomous assets. Automated planners based upon the Nash equilibrium concept in non-zero sum games are one option. Because such planners inherently consider possible adversarial actions, assets are able to adapt to, and to some extent predict, potential enemy actions. However, these planners must function properly both in cases in which a pure Nash strategy does not exist and in scenarios possessing multiple Nash equilibria. Another issue that needs to be overcome is the scalability of the Nash equilibrium. That is, as the dimensionality of the problem increases, the Nash strategies become unfeasible to compute using traditional methodologies. In this paper we introduce the concept of near-Nash strategies as a mechanism to overcome these difficulties. We then illustrate this concept by deriving the near-Nash strategies and using these strategies as the basis for an intelligent battle plan for heterogeneous teams of autonomous combat air vehicles in the Multi-Team Dynamic Weapon Target Assignment model.

Status of Liquid Oxygen/Liquid Methane Injector Study for a Mars Ascent Engine

NASA Technical Reports Server (NTRS)

Trinh, Huu Ogyic; Cramer, John M.

1998-01-01

Preliminary mission studies for human exploration of Mars have been performed at Marshall Space Flight Center (MSFC). These studies indicate that for non-toxic chemical rockets only a cryogenic propulsion system would provide high enough performance to be considered for a Mars ascent vehicle. Although the mission is possible with Earth-supplied propellants for this vehicle, utilization of in-situ propellants is highly attractive. This option would significantly reduce the overall mass of the return vehicle. Consequently, the cost of the mission would be greatly reduced because the number and size of the Earth launch vehicle(s) needed for the mission decrease. NASA/Johnson Space Center has initiated several concept studies (2) of in-situ propellant production plants. Liquid oxygen (LOX) is the primary candidate for an in-situ oxidizer. In-situ fuel candidates include methane (CH4), ethylene (C2H4), and methanol (CH3OH). MSFC initiated a technology development program for a cryogenic propulsion system for the Mars human exploration mission in 1998. One part of this technology program is the effort described here: an evaluation of propellant injection concepts for a LOX/liquid methane Mars Ascent Engine (MAE) with an emphasis on light-weight, high efficiency, reliability, and thermal compatibility. In addition to the main objective, hot-fire tests of the subject injectors will be used to test other key technologies including light-weight combustion chamber materials and advanced ignition concepts. This state-of-the-art technology will then be applied to the development of a cryogenic propulsion system that will meet the requirements of the planned Mars sample return (MSR) mission. The current baseline propulsion system for the MSR mission uses a storable propellant combination [monomethyl hydrazine/mixed oxides of nitrogen-25(MMH/MON-25)]. However, a mission option that incorporates in-situ propellant production and utilization for the ascent stage is being carefully considered as a subscale precursor to a future human mission to Mars.

Inservice Elementary and Middle School Teachers' Conceptions of Photosynthesis and Respiration

ERIC Educational Resources Information Center

Krall, Rebecca McNall; Lott, Kimberly H.; Wymer, Carol L.

2009-01-01

The purpose of this descriptive study was to investigate inservice elementary and middle school teachers' conceptions of photosynthesis and respiration, basic concepts they are expected to teach. A forced-choice instrument assessing selected standards-based life science concepts with non-scientific conceptions embedded in distracter options was…

PrEP as peri-conception HIV prevention for women and men

PubMed Central

Heffron, Renee; Pintye, Jillian; Matthews, Lynn T.; Weber, Shannon; Mugo, Nelly

2016-01-01

Daily oral tenofovir (TDF)-based pre-exposure prophylaxis (PrEP) is an effective HIV prevention strategy and recommended for men and women with substantial risk of HIV acquisition. The peri-conception period, the stage prior to pregnancy when condom use is necessarily reduced, has elevated HIV risk that can be mitigated by PrEP use. Data from a randomized trial suggest that peri-conception PrEP use by HIV-seronegative women does not increase the risk of pregnancy loss, birth defects or congenital anomalies, preterm birth, or infant growth faltering. Women considering PrEP use throughout pregnancy must weigh the known increased risk of HIV acquisition with unknown risks of drug effects on infant growth. PrEP has been used safely by HIV-seronegative men with HIV-seropositive female partners who have become pregnant. As an effective user-controlled HIV prevention strategy, PrEP offers autonomy and empowerment for HIV prevention and can be recommended alongside antiretroviral therapy, fertility screening, vaginal self-insemination, intercourse timed to peak fertility, medically assisted reproduction, and other safer conception strategies to provide multiple options. The integration of PrEP into safer conception programs is warranted and will safely reduce HIV transmission to women, men and children during the peri-conception period. PMID:26993627

Management/Technical Interaction in Integrated Information System Development.

ERIC Educational Resources Information Center

Bagley, Clarence H.; Gardner, Don E.

The integrated information system element of the management information system concept has practical applications for management in the areas of both information analysis and decision-model building. Four basic options for achieving integration in operational data systems are: a default option, the coordinated file option, the distributed…

Engaging Adolescents to Inform the Development of a Mobile Gaming App to Incentivize Physical Activity.

PubMed

Pope, Lizzy; Garnett, Bernice; Dibble, Marguerite

2017-08-29

Involving youth in the development of a mobile game designed to increase physical activity may increase relevancy and adoption. To share the development process used to create a gaming app aimed at incentivizing physical activity in high school students. Five focus groups were conducted with high school students (N=50) to understand gaming behaviors. A subset of students from the focus groups chose to complete a Web-based survey (N=10). Four different versions of gaming artwork and concept design based on student input were pilot tested (N=35), and group consensus building determined the direction of the game. The 4 game versions differed in their artwork style and gaming concept with some requiring competition versus cooperation, or being more individual versus team based. Group consensus building meant that all artwork and game concept options were displayed at the front of a classroom. Students could then vote for their top artwork and concept choices by putting stickers on the top 1 or 2 artwork and concept options that they liked best. Once all votes were cast, investigators discussed the voting results with students, and brainstormed ways to incorporate popular aspects of the 3 "losing" artwork and game concepts into the winning ideas. Focus group transcripts were analyzed for common themes. Artwork and gaming concept-voting data was tallied at the time of voting to share with students in real time. Focus groups and survey results revealed important themes for a successful gaming app: (1) competition, (2) balanced in-game rewards, (3) accessibility, and (4) aesthetic features. Consensus voting indicated the popularity of a collaborative competitive content design (35/66, 53%) and playful art (27/71, 38%). To ensure saliency and effectiveness of game-based physical activity interventions, youth need to be included in design and implementation. Furthermore, the unique preferences and social constructs of high school students need to be considered during intervention development. ©Lizzy Pope, Bernice Garnett, Marguerite Dibble. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 29.08.2017.

Development of a Thin Film Primary Surface Heat Exchanger for Advanced Power Cycles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allison, Tim; Beck, Griffin; Bennett, Jeffrey

This project objective is to develop a high-temperature design upgrade for an existing primary surface heat exchanger so that the redesigned hardware is capable of operation in CO 2 at temperatures up to 1,510°F (821°C) and pressure differentials up to 130 psi (9 bar). The heat exchanger is proposed for use as a recuperator in an advanced low-pressure oxy-fuel Brayton cycle that is predicted to achieve over 50% thermodynamic efficiency, although the heat exchanger could also be used in other high-temperature, low-differential pressure cycles. This report describes the progress to date, which includes continuing work performed to select and testmore » new candidate materials for the recuperator redesign, final mechanical and thermal performance analysis results of various redesign concepts, and the preliminary design of a test loop for the redesigned recuperator including a budgetary estimate for detailed test loop design, procurement, and test operation. A materials search was performed in order to investigate high-temperature properties of many candidate materials, including high-temperature strength and nickel content. These properties were used to rank the candidate materials, resulting in a reduced list of nine materials for corrosion testing. Multiple test rigs were considered and analyzed for short-term corrosion testing and Thermal Gravimetric Analysis (TGA) was selected as the most cost-effective option for evaluating corrosion resistance of the candidate materials. In addition, tantalum, niobium, and chromium coatings were identified as potential options for increased corrosion resistance. The test results show that many materials exhibit relatively low weight gain rates, and that niobium and tantalum coatings may improve corrosion resistance for many materials, while chromium coatings appear to oxidize and debond quickly. Metallurgical analysis of alloys was also performed, showing evidence of intergranular attack in 282 that may cause long-term reliability problems in CO 2 service at these temperatures. However, long-term testing in a flowing environment is recommended in order to understand accurately the severity of the attack. Detailed economic modeling of the existing air cycle recuperator and CO 2 cycle recuperator options was also completed, including costs for material, fabrication, fuel, maintenance, and operation. The analysis results show that the increased capital cost for high-temperature materials may be offset by higher cycle efficiencies, decreasing the overall lifetime cost of the system. The economic analysis also examines costs associated with increased pressure drop and material changes for two redesign options. These results show that, even with slightly reduced performance and/or higher material costs, the lifetime cost per energy production may still be reduced by over 12%. The existing recuperator design information was provided by Solar Turbines, Inc. via several models, drawings, and design handoff meetings. Multiple fluid/thermal and structural models were created in order to analyze critical recuperator performance and mechanical strength in critical areas throughout the redesign process. These models were analyzed for a baseline condition (consistent with current Mercury 50 operation) for validation purposes. Results are presented for heat transfer coefficients and pressure drops, matching well with the existing operational data. Simulation of higher-temperature CO 2 conditions was also performed, showing a slight expected increase in both heat transfer and pressure drop. Mechanical analysis results for critical areas on the cross-flow and counter-flow sheets have also been obtained for air and CO 2 cases. These results show similar stresses in both cases but significantly reduced safety factors for the CO 2 case due to reduced yield and creep rupture strengths of alloy 625 at the higher temperatures. A concept brainstorm session and initial down-selection were completed in order to identify promising redesign options for further analysis. Detailed analysis of all promising redesign options was performed via finite element and computational fluid dynamic simulations in order to characterize mechanical and thermal-fluid performance of each option. These options included material change, various sheet thickness configurations, pitch and phasing of cross-flow and counter-flow sheets, and separator sheets. The analysis results have identified two viable redesign options that maintain existing safety margins optimally through a material change to Haynes 282 and (A) sheet thickness increases of 40% on the counter-flow sheet and 75% on the hot side cross-flow corrugation sheet or (B) addition of a separator sheet in the counter-flow section while maintaining the original counter-flow sheet thickness and increasing the cross-flow corrugation sheet thickness by 90% to account for the increase in cell height. While both options satisfy mechanical stress constraints, the separator sheet design has a higher part count, slightly reduced heat transfer, and slightly higher pressure drop than the first option and is not preferred. Finally, several test loop concepts have been developed for different full-scale and reduced-scale recuperator testing options. For each option, various loop components, such as heat exchangers, valves, heaters, and compressors, were evaluated in an effort to maximize utilization of existing resources. All concepts utilize an existing 3-MW CO 2 compressor, heater, and loop coolers, but the concepts vary by incorporating different amounts of new equipment for achieving various flow rates (all concepts operate at design pressure and temperature). The third concept achieves a 1 kg/s test without purchasing any costly equipment (coolers, heaters, blowers, etc.). Since the stacked cell design of the recuperator results in the same flow conditions at each core cell (even for a reduced-scale test). Thus, test loop Concept #3 was selected for the preliminary design. This loop design is detailed within the report, culminating in a budgetary estimate of $1,013,000.00 for the detailed design, construction, commissioning, and operation of a high-temperature recuperator test loop.« less

Advanced multiple access concepts in mobile satellite systems

NASA Technical Reports Server (NTRS)

Ananasso, Fulvio

1990-01-01

Some multiple access strategies for Mobile Satellite Systems (MSS) are discussed. These strategies were investigated in the context of three separate studies conducted for the International Maritime Satellite Organization (INMARSAT) and the European Space Agency (ESA). Satellite-Switched Frequency Division Multiple Access (SS-FDMA), Code Division Multiple Access (CDMA), and Frequency-Addressable Beam architectures are addressed, discussing both system and technology aspects and outlining advantages and drawbacks of either solution with associated relevant hardware issues. An attempt is made to compare the considered option from the standpoint of user terminal/space segment complexity, synchronization requirements, spectral efficiency, and interference rejection.

Space station crew safety alternatives study. Volume 3: Safety impact of human factors

NASA Technical Reports Server (NTRS)

Rockoff, L. A.; Raasch, R. F.; Peercy, R. L., Jr.

1985-01-01

The first 15 years of accumulated space station concepts for Initial Operational Capability (IOC) during the early 1990's was considered. Twenty-five threats to the space station are identified and selected threats addressed as impacting safety criteria, escape and rescue, and human factors safety concerns. Of the 25 threats identified, eight are discussed including strategy options for threat control: fire, biological or toxic contamination, injury/illness, explosion, loss of pressurization, radiation, meteoroid penetration and debris. Of particular interest here is volume three (of five volumes) pertaining to the safety impact of human factors.

[Sensitivity to change].

PubMed

Igl, W; Zwingmann, C; Faller, H

2005-04-01

In rehabilitation research patient questionnaires are widely used for evaluative purposes, i. e. to measure improvements or deteriorations over time. This is only possible if the questionnaires applied appropriately reflect "true" change over time, i. e. they have to be sensitive to change. The aim of this paper is to point out the importance of the "sensitivity to change" concept for evaluative assessment tools and evaluative studies, respectively, considering quality of life research as an example. Various qualitative aspects, e. g. scaling of response options of assessment tools, are covered as well as quantitative methods, i. e. study designs and indices. Furthermore, recommendations for interpretation are given.

Reconfigurable Computing Concepts for Space Missions: Universal Modular Spares

NASA Technical Reports Server (NTRS)

Patrick, M. Clinton

2007-01-01

Computing hardware for control, data collection, and other purposes will prove many times over crucial resources in NASA's upcoming space missions. Ability to provide these resources within mission payload requirements, with the hardiness to operate for extended periods under potentially harsh conditions in off-World environments, is daunting enough without considering the possibility of doing so with conventional electronics. This paper examines some ideas and options, and proposes some initial approaches, for logical design of reconfigurable computing resources offering true modularity, universal compatibility, and unprecedented flexibility to service all forms and needs of mission infrastructure.

Analysis of space systems study for the space disposal of nuclear waste study report. Volume 2: Technical report

NASA Technical Reports Server (NTRS)

1981-01-01

Reasonable space systems concepts were systematically identified and defined and a total system was evaluated for the space disposal of nuclear wastes. Areas studied include space destinations, space transportation options, launch site options payload protection approaches, and payload rescue techniques. Systems level cost and performance trades defined four alternative space systems which deliver payloads to the selected 0.85 AU heliocentric orbit destination at least as economically as the reference system without requiring removal of the protective radiation shield container. No concepts significantly less costly than the reference concept were identified.

A Power Conversion Concept for the Jupiter Icy Moons Orbiter

NASA Technical Reports Server (NTRS)

Mason, Lee S.

2003-01-01

The Jupiter Icy Moons Orbiter (JIMO) mission is currently under study by the Office of Space Science under the Project Prometheus Program. JIMO is examining the use of Nuclear Electric Propulsion (NEP) to carry scientific payloads to three Jovian moons. A potential power system concept includes dual 100 kWe Brayton converters, a deployable pumped loop heat rejection subsystem, and a 400 Vac Power Management and Distribution (PMAD) bus. Many trades were performed in aniving at this candidate power system concept. System-level studies examined design and off-design operating modes, determined startup requirements, evaluated subsystem redundancy options, and quantified the mass and radiator area of reactor power systems from 20 to 200 kWe. In the Brayton converter subsystem, studies were performed to investigate converter packaging options, and assess the induced torque effects on spacecraft dynamics due to rotating machinery. In the heat rejection subsystem, design trades were conducted on heat transport approaches, material and fluid options, and deployed radiator geometries. In the PMAD subsystem, the overall electrical architecture was defined and trade studies examined distribution approaches, voltage levels, and cabling options.

Planetary entry, descent, and landing technologies

NASA Astrophysics Data System (ADS)

Pichkhadze, K.; Vorontsov, V.; Polyakov, A.; Ivankov, A.; Taalas, P.; Pellinen, R.; Harri, A.-M.; Linkin, V.

2003-04-01

Martian meteorological lander (MML) is intended for landing on the Martian surface in order to monitor the atmosphere at landing point for one Martian year. MMLs shall become the basic elements of a global network of meteorological mini-landers, observing the dynamics of changes of the atmospheric parameters on the Red Planet. The MML main scientific tasks are as follows: (1) Study of vertical structure of the Martian atmosphere throughout the MML descent; (2) On-surface meteorological observations for one Martian year. One of the essential factors influencing the lander's design is its entry, descent, and landing (EDL) sequence. During Phase A of the MML development, five different options for the lander's design were carefully analyzed. All of these options ensure the accomplishment of the above-mentioned scientific tasks with high effectiveness. CONCEPT A (conventional approach): Two lander options (with a parachute system + airbag and an inflatable airbrake + airbag) were analyzed. They are similar in terms of fulfilling braking phases and completely analogous in landing by means of airbags. CONCEPT B (innovative approach): Three lander options were analyzed. The distinguishing feature is the presence of inflatable braking units (IBU) in their configurations. SELECTED OPTION (innovative approach): Incorporating a unique design approach and modern technologies, the selected option of the lander represents a combination of the options analyzed in the framework of Concept B study. Currently, the selected lander option undergoes systems testing (Phase D1). Several MMLs can be delivered to Mars in frameworks of various missions as primary or piggybacking payload: (1) USA-led "Mars Scout" (2007); (2) France-led "NetLander" (2007/2009); (3) Russia-led "Mars-Deimos-Phobos sample return" (2007); (4) Independent mission (currently under preliminary study); etc.

Implementation Options for the PROPEL Electrodynamic Tether Demonstration Mission

NASA Technical Reports Server (NTRS)

Bilen, Sven G.; Johnson, Les; Gilchrist, Brian E.; Hoyt, Robert P.; Elder, Craig H.; Fuhrhop, Keith P.; Scadera, Michael P.; Stone, Nobie H.

2014-01-01

The PROPEL flight mission concept will demonstrate the safe use of an electrodynamic tether for generating thrust. PROPEL is being designed to be a versatile electrodynamic-tether system for multiple end users and to be flexible with respect to platform. As such, several implementation options are being explored, including a comprehensive mission design for PROPEL with a mission duration of six months; a space demonstration mission concept design with configuration of a pair of tethered satellites, one of which is the Japanese H-II Transfer Vehicle; and an ESPA-based system. We report here on these possible implementation options for PROPEL. electrodynamic tether; PROPEL demonstration mission; propellantless propulsion

Scientific Issues Relevant to Setting Regulatory Criteria to Identify Endocrine-Disrupting Substances in the European Union.

PubMed

Slama, Rémy; Bourguignon, Jean-Pierre; Demeneix, Barbara; Ivell, Richard; Panzica, Giancarlo; Kortenkamp, Andreas; Zoeller, R Thomas

2016-10-01

Endocrine disruptors (EDs) are defined by the World Health Organization (WHO) as exogenous compounds or mixtures that alter function(s) of the endocrine system and consequently cause adverse effects in an intact organism, or its progeny, or (sub)populations. European regulations on pesticides, biocides, cosmetics, and industrial chemicals require the European Commission to establish scientific criteria to define EDs. We address the scientific relevance of four options for the identification of EDs proposed by the European Commission. Option 1, which does not define EDs and leads to using interim criteria unrelated to the WHO definition of EDs, is not relevant. Options 2 and 3 rely on the WHO definition of EDs, which is widely accepted by the scientific community, with option 3 introducing additional categories based on the strength of evidence (suspected EDs and endocrine-active substances). Option 4 adds potency to the WHO definition, as a decision criterion. We argue that potency is dependent on the adverse effect considered and is scientifically ambiguous, and note that potency is not used as a criterion to define other particularly hazardous substances such as carcinogens and reproductive toxicants. The use of potency requires a context that goes beyond hazard identification and corresponds to risk characterization, in which potency (or, more relevantly, the dose-response function) is combined with exposure levels. There is scientific agreement regarding the adequacy of the WHO definition of EDs. The potency concept is not relevant to the identification of particularly serious hazards such as EDs. As is common practice for carcinogens, mutagens, and reproductive toxicants, a multi-level classification of ED based on the WHO definition, and not considering potency, would be relevant (corresponding to option 3 proposed by the European Commission). Slama R, Bourguignon JP, Demeneix B, Ivell R, Panzica G, Kortenkamp A, Zoeller RT. 2016. Scientific issues relevant to setting regulatory criteria to identify endocrine disrupting substances in the European Union. Environ Health Perspect 124:1497-1503; http://dx.doi.org/10.1289/EHP217.

Scientific Issues Relevant to Setting Regulatory Criteria to Identify Endocrine-Disrupting Substances in the European Union

PubMed Central

Slama, Rémy; Bourguignon, Jean-Pierre; Demeneix, Barbara; Ivell, Richard; Panzica, Giancarlo; Kortenkamp, Andreas; Zoeller, R. Thomas

2016-01-01

Background: Endocrine disruptors (EDs) are defined by the World Health Organization (WHO) as exogenous compounds or mixtures that alter function(s) of the endocrine system and consequently cause adverse effects in an intact organism, or its progeny, or (sub)populations. European regulations on pesticides, biocides, cosmetics, and industrial chemicals require the European Commission to establish scientific criteria to define EDs. Objectives: We address the scientific relevance of four options for the identification of EDs proposed by the European Commission. Discussion: Option 1, which does not define EDs and leads to using interim criteria unrelated to the WHO definition of EDs, is not relevant. Options 2 and 3 rely on the WHO definition of EDs, which is widely accepted by the scientific community, with option 3 introducing additional categories based on the strength of evidence (suspected EDs and endocrine-active substances). Option 4 adds potency to the WHO definition, as a decision criterion. We argue that potency is dependent on the adverse effect considered and is scientifically ambiguous, and note that potency is not used as a criterion to define other particularly hazardous substances such as carcinogens and reproductive toxicants. The use of potency requires a context that goes beyond hazard identification and corresponds to risk characterization, in which potency (or, more relevantly, the dose–response function) is combined with exposure levels. Conclusions: There is scientific agreement regarding the adequacy of the WHO definition of EDs. The potency concept is not relevant to the identification of particularly serious hazards such as EDs. As is common practice for carcinogens, mutagens, and reproductive toxicants, a multi-level classification of ED based on the WHO definition, and not considering potency, would be relevant (corresponding to option 3 proposed by the European Commission). Citation: Slama R, Bourguignon JP, Demeneix B, Ivell R, Panzica G, Kortenkamp A, Zoeller RT. 2016. Scientific issues relevant to setting regulatory criteria to identify endocrine disrupting substances in the European Union. Environ Health Perspect 124:1497–1503; http://dx.doi.org/10.1289/EHP217 PMID:27108591

An analytical approach to air defense: cost, effectiveness and SWOT analysis of employing fighter aircraft and modern SAM systems

NASA Astrophysics Data System (ADS)

Kus, Orcun; Kocaman, Ibrahim; Topcu, Yucel; Karaca, Volkan

2012-05-01

The problem of defending a specific airspace is among the main issues a military commander to solve. Proper protection of own airspace is crucial for mission success at the battlefield. The military doctrines of most world armed forces involve two main options of defending the airspace. One of them is utilizing formations of fighter aircraft, which is a flexible choice. The second option is deploying modern SAM (Surface to Air Missile) systems, which is more expansive. On the other hand the decision makers are to cope with miscellaneous restrictions such as the budgeting problems. This study defines air defense concept according to modern air warfare doctrine. It considers an air defense scenario over an arbitrary airspace and compares the performance and cost-effectiveness of employing fighter aircraft and SAM systems. It also presents SWOT (Strenghts - Weakness - Opportunities - Threats) analyses of air defense by fighter aircraft and by modern SAMs and tries to point out whichever option is better. We conclude that deploying SAMs has important advantages over using fighter aircraft by means of interception capacity within a given time period and is cost-effective.

The rapid reproducers paradox: population control and individual procreative rights.

PubMed

Wissenburg, M

1998-01-01

This article argues that population policies need to be evaluated from macro and micro perspectives and to consider individual rights. Ecological arguments that are stringent conditions of liberal democracy are assessed against a moral standard. The moral standard is applied to a series of reasons for limiting procreative rights in the cause of sustainability. The focus is directly on legally enforced antinatalist measures and not on indirect policies with incentives and disincentives. The explicit assumption is that population policy violates the fairness to individuals for societal gain and that population policies are incompatible with stringent conditions of liberal democracy. The author identifies the individual-societal tradeoff as the "rapid reproducers paradox." The perfect sustainable population level is either not possible or is a repugnant alternative. 12 ecological arguments are presented, and none are found compatible with notions of a liberal democracy. Three alternative antinatalist options are the acceptance of less rigid and still coercive policies, amendments to the conception of liberal democracy, or loss of hope and choice of noncoercive solutions to sustainability, none of which is found viable. If voluntary abstinence and distributive solutions fail, then frugal demand options and technological supply options both will be necessary.

Editorial Commentary: Graft Removal Versus Retention for Septic Arthritis After Anterior Cruciate Ligament Reconstruction: Accounting for Patient Preference Flips the Script on Current Practice.

PubMed

Cote, Mark P

2018-03-01

Septic arthritis is a rare but potentially devastating complication after anterior cruciate ligament (ACL) reconstruction. Studies examining surgical treatment options including graft retention and removal are largely inconclusive. Although the literature indicated that 43.8% of patients who have the graft removed later go on to have a revision ACL reconstruction compared with only 6.5% among those whose graft is retained, this expected-value decision analysis found removal to be the optimal treatment for patients with septic arthritis after ACL reconstruction. This is largely based on patient preference to avoid a late reoperation for residual knee infection. These findings support the concept of utility when considering treatment options for patients with a septic knee. For some, avoiding a late reoperation for a persistent infection is the most important factor and as such graft removal may be the most appropriate treatment to produce a positive outcome among these patients despite the fact that currently, an attempt at graft retention could represent the generally preferred treatment option among practicing surgeons. Copyright © 2017. Published by Elsevier Inc.

Novel implications in the treatment of hepatocellular carcinoma

PubMed Central

Best, Jan; Schotten, Clemens; Theysohn, Jens M.; Wetter, Axel; Müller, Stefan; Radünz, Sonia; Schulze, Maren; Canbay, Ali; Dechêne, Alexander; Gerken, Guido

2017-01-01

Worldwide hepatocellular carcinoma remains one of the leading causes of cancer-related death, associated with a poor prognosis due to late diagnosis in the majority of cases. Physicians at care are frequently confronted with patients who are ineligible for curative treatment such as liver resection, transplantation or radiofrequency ablation. Besides established palliative locoregional therapies, such as ablation or chemoembolization, new treatment options, such as microwave ablation, drug-eluting bead transarterial chemoembolization or selective internal radiation therapy, are emerging; however, data from randomized controlled trials are still lacking. In order to achieve optimal tumor control, patients should receive tailored treatment concepts, considering their tumor burden, liver function and performance status, instead of strictly assigning patients to treatment modalities following algorithms that may be partly very restrictive. Palliative locoregional pretreatment might facilitate downstaging to ensure later curative resection or transplantation. In addition, the combined utilization of different locoregional treatment options or systemic co-treatment has been the subject of several trials. In cases where local tumor control cannot be achieved, or in the scenario of extrahepatic spread, sorafenib remains the only approved systemic therapy option. Alternative targeted therapies, such as immune checkpoint inhibitors have shown encouraging preliminary results, while data from phase III studies are pending. PMID:28042235

Asteroid Redirect Robotic Mission: Robotic Boulder Capture Option Overview

NASA Technical Reports Server (NTRS)

Mazanek, Daniel D.; Merrill, Raymond G.; Belbin, Scott P.; Reeves, David M.; Earle, Kevin D.; Naasz, Bo J.; Abell, Paul A.

2014-01-01

The National Aeronautics and Space Administration (NASA) is currently studying an option for the Asteroid Redirect Robotic Mission (ARRM) that would capture a multi-ton boulder (typically 2-4 meters in size) from the surface of a large (is approximately 100+ meter) Near-Earth Asteroid (NEA) and return it to cislunar space for subsequent human and robotic exploration. This alternative mission approach, designated the Robotic Boulder Capture Option (Option B), has been investigated to determine the mission feasibility and identify potential differences from the initial ARRM concept of capturing an entire small NEA (4-10 meters in size), which has been designated the Small Asteroid Capture Option (Option A). Compared to the initial ARRM concept, Option B allows for centimeter-level characterization over an entire large NEA, the certainty of target NEA composition type, the ability to select the boulder that is captured, numerous opportunities for mission enhancements to support science objectives, additional experience operating at a low-gravity planetary body including extended surface contact, and the ability to demonstrate future planetary defense strategies on a hazardous-size NEA. Option B can leverage precursor missions and existing Agency capabilities to help ensure mission success by targeting wellcharacterized asteroids and can accommodate uncertain programmatic schedules by tailoring the return mass.

Venus Mobile Explorer with RPS for Active Cooling: A Feasibility Study

NASA Technical Reports Server (NTRS)

Leifer, Stephanie D.; Green, Jacklyn R.; Balint, Tibor S.; Manvi, Ram

2009-01-01

We present our findings from a study to evaluate the feasibility of a radioisotope power system (RPS) combined with active cooling to enable a long-duration Venus surface mission. On-board power with active cooling technology featured prominently in both the National Research Council's Decadal Survey and in the 2006 NASA Solar System Exploration Roadmap as mission-enabling for the exploration of Venus. Power and cooling system options were reviewed and the most promising concepts modeled to develop an assessment tool for Venus mission planners considering a variety of future potential missions to Venus, including a Venus Mobile Explorer (either a balloon or rover concept), a long-lived Venus static lander, or a Venus Geophysical Network. The concepts modeled were based on the integration of General Purpose Heat Source (GPHS) modules with different types of Stirling cycle heat engines for power and cooling. Unlike prior investigations which reported on single point design concepts, this assessment tool allows the user to generate either a point design or parametric curves of approximate power and cooling system mass, power level, and number of GPHS modules needed for a "black box" payload housed in a spherical pressure vessel.

Adaptability of optimization concept in the context of cryogenic distribution for superconducting magnets of fusion machine

NASA Astrophysics Data System (ADS)

Sarkar, Biswanath; Bhattacharya, Ritendra Nath; Vaghela, Hitensinh; Shah, Nitin Dineshkumar; Choukekar, Ketan; Badgujar, Satish

2012-06-01

Cryogenic distribution system (CDS) plays a vital role for reliable operation of largescale fusion machines in a Tokamak configuration. Managing dynamic heat loads from the superconducting magnets, namely, toroidal field, poloidal field, central solenoid and supporting structure is the most important function of the CDS along with the static heat loads. Two concepts are foreseen for the configuration of the CDS: singular distribution and collective distribution. In the first concept, each magnet is assigned with one distribution box having its own sub-cooler bath. In the collective concept, it is possible to share one common bath for more than one magnet system. The case study has been performed with an identical dynamic heat load profile applied to both concepts in the same time domain. The choices of a combined system from the magnets are also part of the study without compromising the system functionality. Process modeling and detailed simulations have been performed for both the options using Aspen HYSYS®. Multiple plasma pulses per day have been considered to verify the residual energy deposited in the superconducting magnets at the end of the plasma pulse. Preliminary 3D modeling using CATIA® has been performed along with the first level of component sizing.

The shortened dental arch concept: awareness and opinion of dentists in Victoria, Australia.

PubMed

Abuzar, M A; Humplik, A J; Shahim, N

2015-09-01

The occlusion of a complete dental arch is generally desirable but not necessary nor always achievable in many individuals. It is, however, relevant for dentists to consider what minimum number of teeth is required by individuals for oral function. This study investigated dentists' awareness and opinion of the shortened dental arch (SDA) concept in an Australian context. A self-administered voluntary and anonymous questionnaire was mailed to a sample of 434 dentists, randomly selected from both rural and metropolitan locations in Victoria, Australia. The information collected included awareness of the SDA concept and its application as a treatment option. More than half of the respondents (61%) were aware of the SDA concept. All respondents 'agreed' or 'strongly agreed' with the seven criteria of SDA proposed in this study based on Käyser (1989). The majority (78.4%) believed that the SDA concept is useful in clinical practice. Dentists with <20 years of experience expressed more awareness compared to others (χ(2) test, p = 0.004). Most dentists who responded to this survey agreed that the SDA is a practical and useful treatment modality for older adults with limitations to complex restorative care. However, application of the SDA varied considerably among dentists. © 2015 Australian Dental Association.

Energy from space; Proceedings of the Symposium on Solar Energy from Space, Vienna, Austria, August 9-21, 1982

NASA Astrophysics Data System (ADS)

Freeman, J. W.

Aspects of solar power generation in space are considered. The subjects discussed include: a vision of future energy from space; solar power satellite concept for utilization of energy from space; the institutional challenge of solar power satellites; system study of the solar power satellite concept; market potential and possible limitations for satellite solar power stations; financing a solar power satellite project; and European questions related to satellite power systems. Also addressed are: options and high payoff choices for transportation; an electric propulsion transportation system from low-earth orbit to geostationary orbit utilizing beamed microwave power; the Canadarm robot arm of the Shuttle Remote Manipulator System; an early experimental solar power satellite; power economical considerations for the integration of terrestrial and extraterrestrial solar generators into existing power generation stations; and space solar power in perspective. For individual items see A84-21477 to A84-21489

Survey and Method for Determination of Trajectory Predictor Requirements

NASA Technical Reports Server (NTRS)

Rentas, Tamika L.; Green, Steven M.; Cate, Karen Tung

2009-01-01

A survey of air-traffic-management researchers, representing a broad range of automation applications, was conducted to document trajectory-predictor requirements for future decision-support systems. Results indicated that the researchers were unable to articulate a basic set of trajectory-prediction requirements for their automation concepts. Survey responses showed the need to establish a process to help developers determine the trajectory-predictor-performance requirements for their concepts. Two methods for determining trajectory-predictor requirements are introduced. A fast-time simulation method is discussed that captures the sensitivity of a concept to the performance of its trajectory-prediction capability. A characterization method is proposed to provide quicker, yet less precise results, based on analysis and simulation to characterize the trajectory-prediction errors associated with key modeling options for a specific concept. Concept developers can then identify the relative sizes of errors associated with key modeling options, and qualitatively determine which options lead to significant errors. The characterization method is demonstrated for a case study involving future airport surface traffic management automation. Of the top four sources of error, results indicated that the error associated with accelerations to and from turn speeds was unacceptable, the error associated with the turn path model was acceptable, and the error associated with taxi-speed estimation was of concern and needed a higher fidelity concept simulation to obtain a more precise result

Initiating decision-making in neurology consultations: 'recommending' versus 'option-listing' and the implications for medical authority.

PubMed

Toerien, Merran; Shaw, Rebecca; Reuber, Markus

2013-07-01

This article compares two practices for initiating treatment decision-making, evident in audio-recorded consultations between a neurologist and 13 patients in two hospital clinics in the UK. We call these 'recommending' and 'option-listing'. The former entails making a proposal to do something; the latter entails the construction of a list of options. Using conversation analysis (CA), we illustrate each, showing that the distinction between these two practices matters to participants. Our analysis centres on two distinctions between the practices: epistemic differences and differences in the slots each creates for the patient's response. Considering the implications of our findings for understanding medical authority, we argue that option-listing - relative to recommending - is a practice whereby clinicians work to relinquish a little of their authority. This article contributes, then, to a growing body of CA work that offers a more nuanced, tempered account of medical authority than is typically portrayed in the sociological literature. We argue that future CA studies should map out the range of ways - in addition to recommending - in which treatment decision-making is initiated by clinicians. This will allow for further evidence-based contributions to debates on the related concepts of patient participation, choice, shared decision-making and medical authority. © 2013 The Authors. Sociology of Health & Illness © 2013 Foundation for the Sociology of Health & Illness/John Wiley & Sons Ltd.

Preferential Option for the Poor: Making a Pedagogical Choice

ERIC Educational Resources Information Center

Kirylo, James D.

2006-01-01

When children are sick, hurt, or in desperate need, parents/caregivers naturally make preferential options for them. Yet, as it relates to social justice, particularly when working with students from marginalized and poverty situations, the concept of making a preferential option in a school setting is not as clear. However, a school setting is a…

Medium Earth Orbit Scatterometer (MEOScat) Concept Phase Study

NASA Technical Reports Server (NTRS)

Spencer, Michael W.

2004-01-01

In this report, advanced scatterometer concept options to operate in the post-SeaWinds era are examined. In order to meet the future requirements of scientific and operational users, a variety of scatterometer systems capable of producing improved wind vector products are evaluated. Special emphasis is placed on addressing concept options that operate at higher altitudes in order to improve the temporal revisit time. A preliminary set of generalized wind measurement goals designed to meet the future needs of both scientific and operational communities is put forth. Geophysically based measurement constraints (such as allowable carrier frequencies and measurement incidence angles) are identified. It was found that a potential key constraint at higher satellite altitudes is the longer time required to make all of the azimuth measurements. The revisit and coverage characteristics of a variety of platform orbits throughout the MEO range is studied in detail, and a discussion of the associated increase in radiation is presented. The "trade space" of scatterometer architectures and design options, along with associated advantages and disadvantages, is described for mission options in the MEO range. Finally, key technology studies that will enable further development of a MEO scatterometer mission are identified.

A CMOS pixel sensor prototype for the outer layers of linear collider vertex detector

NASA Astrophysics Data System (ADS)

Zhang, L.; Morel, F.; Hu-Guo, C.; Himmi, A.; Dorokhov, A.; Hu, Y.

2015-01-01

The International Linear Collider (ILC) expresses a stringent requirement for high precision vertex detectors (VXD). CMOS pixel sensors (CPS) have been considered as an option for the VXD of the International Large Detector (ILD), one of the detector concepts proposed for the ILC. MIMOSA-31 developed at IPHC-Strasbourg is the first CPS integrated with 4-bit column-level ADC for the outer layers of the VXD, adapted to an original concept minimizing the power consumption. It is composed of a matrix of 64 rows and 48 columns. The pixel concept combines in-pixel amplification with a correlated double sampling (CDS) operation in order to reduce the temporal noise and fixed pattern noise (FPN). At the bottom of the pixel array, each column is terminated with a self-triggered analog-to-digital converter (ADC). The ADC design was optimized for power saving at a sampling frequency of 6.25 MS/s. The prototype chip is fabricated in a 0.35 μm CMOS technology. This paper presents the details of the prototype chip and its test results.

The Reinforcement of Ableism: Normality, the Medical Model of Disability, and Humanism in Applied Behavior Analysis and ASD.

PubMed

Shyman, Eric

2016-10-01

The field of educating individuals with Autism Spectrum Disorder has ever been rife with controversy regarding issues ranging from etiology and causation to effective intervention and education options. One such basis for controversy has been between humanism, and humanistic philosophical concepts, and its fundamental differences with behaviorism, and behavioristic philosophical concepts. These differences have long been debated, and the belief that the two orientations are generally mutually exclusive has been largely maintained. Recently, however, there has been some resurgence of interest in reconciling some of the fundamental humanistic and behavioristic tenets. Most of these discussions, however, center on specific interventional methodologies as its basis without delving more deeply into the underlying philosophical issues. This article will explore some fundamental humanistic concepts that ought to be reconciled in order for behaviorism to be considered a humanistic practice. While the notion that the possibility of reconciliation is maintained, the central argument maintains that much work needs to be done on the part of behaviorism both philosophically and methodologically in order for such reconciliation to be achieved.

Dilemma of concepts and strategies for the prevention of spread of HIV in relation to human behavior, law and human rights

PubMed Central

Dennin, Reinhard H.; Lafrenz, Michael; Sinn, Arndt; Li, Lan-juan

2011-01-01

The new prevalence data regarding the estimated global number of human immunodeficiency virus positive (HIV+) cases, i.e., including people who are either aware or unaware of their HIV infection in 2010, lead many to wonder why the increase in incidence has reached today’s unprecedented level and escalated within such a short time. This, in spite of prevention campaigns in countries affected by HIV/acquired immune deficiency syndrome (AIDS) with their urgent messages aimed at preventing HIV transmission by promoting changes in individual’s behavior. This article analyzes the background of the prevention strategies, in particular their political, social and legal concepts in terms of human rights, and reveals traits of human behavior not considered thus far. A radical reappraisal is necessary, at social and legislative levels, as well as options additional to current concepts. When ethical issues come up, they become blamed for outmoded moralistic positions. However, ignoring the reality has led to dire consequences from prioritizing individual human rights over society’s collective need to prevent the spread of HIV. PMID:21726067

Actinide Solubility and Speciation in the WIPP [PowerPoint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reed, Donald T.

2015-11-02

The presentation begins with the role and need for nuclear repositories (overall concept, international updates (Sweden, Finland, France, China), US approach and current status), then moves on to the WIPP TRU repository concept (design, current status--safety incidents of February 5 and 14, 2014, path forward), and finally considers the WIPP safety case: dissolved actinide concentrations (overall approach, oxidation state distribution and redox control, solubility of actinides, colloidal contribution and microbial effects). The following conclusions are set forth: (1) International programs are moving forward, but at a very slow and somewhat sporadic pace. (2) In the United States, the Salt repositorymore » concept, from the perspective of the long-term safety case, remains a viable option for nuclear waste management despite the current operational issues/concerns. (3) Current model/PA prediction (WIPP example) are built on redundant conservatisms. These conservatisms are being addressed in the ongoing and future research to fill existing data gaps--redox control of plutonium by Fe(0, II), thorium (analog) solubility studies in simulated brine, contribution of intrinsic and biocolloids to the mobile concentration, and clarification of microbial ecology and effects.« less

Options for flight testing rocket-based combined-cycle (RBCC) engines

NASA Technical Reports Server (NTRS)

Olds, John

1996-01-01

While NASA's current next-generation launch vehicle research has largely focused on advanced all-rocket single-stage-to-orbit vehicles (i.e. the X-33 and it's RLV operational follow-on), some attention is being given to advanced propulsion concepts suitable for 'next-generation-and-a-half' vehicles. Rocket-based combined-cycle (RBCC) engines combining rocket and airbreathing elements are one candidate concept. Preliminary RBCC engine development was undertaken by the United States in the 1960's. However, additional ground and flight research is required to bring the engine to technological maturity. This paper presents two options for flight testing early versions of the RBCC ejector scramjet engine. The first option mounts a single RBCC engine module to the X-34 air-launched technology testbed for test flights up to about Mach 6.4. The second option links RBCC engine testing to the simultaneous development of a small-payload (220 lb.) two-stage-to-orbit operational vehicle in the Bantam payload class. This launcher/testbed concept has been dubbed the W vehicle. The W vehicle can also serve as an early ejector ramjet RBCC launcher (albeit at a lower payload). To complement current RBCC ground testing efforts, both flight test engines will use earth-storable propellants for their RBCC rocket primaries and hydrocarbon fuel for their airbreathing modes. Performance and vehicle sizing results are presented for both options.

Contemporary health care economics: an overview.

PubMed

McLaughlin, Nancy; Ong, Michael K; Tabbush, Victor; Hagigi, Farhad; Martin, Neil A

2014-11-01

Economic evaluations provide a decision-making framework in which outcomes (benefits) and costs are assessed for various alternative options. Although the interest in complete and partial economic evaluations has increased over the past 2 decades, the quality of studies has been marginal due to methodological challenges or incomplete cost determination. This paper provides an overview of the main types of complete and partial economic evaluations, reviews key methodological elements to be considered for any economic evaluation, and reviews concepts of cost determination. The goal is to provide the clinician neurosurgeon with the knowledge and tools needed to appraise published economic evaluations and to direct high-quality health economic evaluations.

Life-threatening hypersplenism due to idiopathic portal hypertension in early childhood: case report and review of the literature

PubMed Central

2010-01-01

Background Idiopathic portal hypertension (IPH) is a disorder of unknown etiology and is characterized clinically by portal hypertension, splenomegaly, and hypersplenism accompanied by pancytopenia. This study evaluates the pathogenic concept of the disease by a systematic review of the literature and illustrates novel pathologic and laboratory findings. Case Presentation We report the first case of uncontrolled splenic hyperperfusion and enlargement with subsequent hypersplenism leading to life-threatening complications of IPH in infancy and emergent splenectomy. Conclusions Our results suggest that splenic NO and VCAM-1, rather than ET-1, have a significant impact on the development of IPH, even at a very early stage of disease. The success of surgical interventions targeting the splenic hyperperfusion suggests that the primary defect in the regulation of splenic blood flow seems to be crucial for the development of IPH. Thus, beside other treatment options splenectomy needs to be considered as a prime therapeutic option for IPH. PMID:20961440

Multi-objective decision-making under uncertainty: Fuzzy logic methods

NASA Technical Reports Server (NTRS)

Hardy, Terry L.

1994-01-01

Selecting the best option among alternatives is often a difficult process. This process becomes even more difficult when the evaluation criteria are vague or qualitative, and when the objectives vary in importance and scope. Fuzzy logic allows for quantitative representation of vague or fuzzy objectives, and therefore is well-suited for multi-objective decision-making. This paper presents methods employing fuzzy logic concepts to assist in the decision-making process. In addition, this paper describes software developed at NASA Lewis Research Center for assisting in the decision-making process. Two diverse examples are used to illustrate the use of fuzzy logic in choosing an alternative among many options and objectives. One example is the selection of a lunar lander ascent propulsion system, and the other example is the selection of an aeration system for improving the water quality of the Cuyahoga River in Cleveland, Ohio. The fuzzy logic techniques provided here are powerful tools which complement existing approaches, and therefore should be considered in future decision-making activities.

Problem Patrons: Reviewing Your Options.

ERIC Educational Resources Information Center

Shuman, Bruce A.

2002-01-01

Considers possible options for public librarians dealing with problem patrons. Highlights include considering the safety of the patrons and staff; general considerations of library security, including security guards, legal responsibility for patrons and staff safety; and working through possible options ahead of time to be more prepared. (LRW)

A Review and Survey of Neurosurgeon-Hospital Relationships: Evolution and Options.

PubMed

Kim, Dong H; Duco, Bernard; Wolterman, Daniel; Stokes, Charles; Brace, Rod; Solomon, Robert A; Barbaro, Nicholas; Westmark, Richard; MacDougall, David; Bean, James; O'Leary, Joanna; Moayeri, Nicole; Dacey, Ralph G; Berger, Mitchel S; Harbaugh, Robert

2017-04-01

As healthcare delivery shifts from fee-for-service, episodic care to pay for performance and population health, both hospitals and physicians are looking for new forms of integration. A number of regulations and restrictions govern physician relationships with hospitals. In this paper, we review the legal basis for such relationships and the options available. We also survey neurosurgeons and hospital executives to gain their perspective on the current situation and likely future. Two series of structured interviews were conducted with 10 neurosurgeons who work in a range of situations in diverse markets, and with Memorial Hermann Healthcare System senior executive leadership. Their responses form the basis for the subsequent discussion. Neurosurgeons can be independent, join a confederation such as an Independent Physician Association or another type of "clinically integrated" network, or be employed by a hospital, medical school, or physician group. With varying levels of integration comes the strength of size, management expertise, negotiating leverage, economies of scale, and possibly financial advantages, but with impact on autonomy and independence. Constructive alignment can lead to a win-win situation for both the individual physician and the organization, but options vary widely due to heterogeneous local conditions. This paper reviews possible relationships, moving along a spectrum from no financial integration to full integration. Concepts such as physician leasing, professional service agreements, "clinical integration," and employment are presented. This paper offers a practical reference that might be useful to a new graduate, independent neurosurgeon considering integration, or employed physicians considering alternatives. Copyright © 2016 by the Congress of Neurological Surgeons.

Analysing urban resilience through alternative stormwater management options: application of the conceptual Spatial Decision Support System model at the neighbourhood scale.

PubMed

Balsells, M; Barroca, B; Amdal, J R; Diab, Y; Becue, V; Serre, D

2013-01-01

Recent changes in cities and their environments, caused by rapid urbanisation and climate change, have increased both flood probability and the severity of flooding. Consequently, there is a need for all cities to adapt to climate and socio-economic changes by developing new strategies for flood risk management. Following a risk paradigm shift from traditional to more integrated approaches, and considering the uncertainties of future urban development, one of the main emerging tasks for city managers becomes the development of resilient cities. However, the meaning of the resilience concept and its operability is still not clear. The goal of this research is to study how urban engineering and design disciplines can improve resilience to floods in urban neighbourhoods. This paper presents the conceptual Spatial Decision Support System (DS3) model which we consider a relevant tool to analyse and then implement resilience into neighbourhood design. Using this model, we analyse and discuss alternative stormwater management options at the neighbourhood scale in two specific areas: Rotterdam and New Orleans. The results obtained demonstrate that the DS3 model confirmed in its framework analysis that stormwater management systems can positively contribute to the improved flood resilience of a neighbourhood.

MODELING CONCEPTS FOR BMP/LID SIMULATION

EPA Science Inventory

Enhancement of simulation options for stormwater best management practices (BMPs) and hydrologic source control is discussed in the context of the EPA Storm Water Management Model (SWMM). Options for improvement of various BMP representations are presented, with emphasis on inco...

Space station needs, attributes and architectural options. Volume 1: Executive summary NASA

NASA Technical Reports Server (NTRS)

1983-01-01

The uses alignment plan was implemented. The existing data bank was used to define a large number of station requirements. Ten to 20 valid mission scenarios were developed. Architectural options as they are influenced by communications operations, subsystem evolvability, and required technology growth are defined. Costing of evolutionary concepts, alternative approaches, and options, was based on minimum design details.

Restoration of Secondary Containment in Double Shell Tank (DST) Pits

DOE Office of Scientific and Technical Information (OSTI.GOV)

SHEN, E.J.

2000-10-05

Cracks found in many of the double-shell tank (DST) pump and valve pits bring into question the ability of the pits to provide secondary containment and remain in compliance with State and Federal regulations. This study was commissioned to identify viable options for maintain/restoring secondary containment capability in these pits. The basis for this study is the decision analysis process which identifies the requirements to be met and the desired goals (decision criteria) that each option will be weighed against. A facilitated workshop was convened with individuals knowledgeable of Tank Farms Operations, engineering practices, and safety/environmental requirements. The outcome ofmore » this workshop was the validation or identification of the critical requirements, definition of the current problem, identification and weighting of the desired goals, baselining of the current repair methods, and identification of potential alternate solutions. The workshop was followed up with further investigations into the potential solutions that were identified in the workshop and through other efforts. These solutions are identified in the body of this report. Each of the potential solutions were screened against the list of requirements and only those meeting the requirements were considered viable options. To expand the field of viable options, hybrid concepts that combine the strongest features of different individual approaches were also examined. Several were identified. The decision analysis process then ranked each of the viable options against the weighted decision criteria, which resulted in a recommended solution. The recommended approach is based upon installing a sprayed on coating system.« less

Completing the third person's perspective on patients' involvement in medical decision-making: approaching the full picture.

PubMed

Kasper, Jürgen; Hoffmann, Frauke; Heesen, Christoph; Köpke, Sascha; Geiger, Friedemann

2012-01-01

Shared decision making is based on the idea of cooperation and partnership between patients and doctors. In this concept both parties may initiate and perform specific decision-making steps. However, the common observation-based instruments focus solely on doctors' behaviour. Content and quality of information provided to involve patients in medical decisions are hardly considered in evaluation of SDM. This study investigates the advantages of a revised observer inventory taking into account these aspects. Based on the OPTION scale, a more comprehensive observation-based inventory was developed, additionally considering both the patient-sided indicators for patient involvement and the criteria of evidence-based patient information. The inventory comprises three scales (doctor, patient, doctor-patient dyad) and 15 indicators each. Rater training and re-analyses of 76 consultations previously analysed using the OPTION scale were conducted. Convergent validities were calculated between the observer-based scales and the patients' ratings on the Shared Decision Making Questionnaire, the Decisional Conflict Scale and the Control Preference Scale. Interrater reliabilities of the revised scales were high (r=.87 to .74) and even higher when only the dyadic perspective was coded (.86). The revised inventory provided additional information on the involvement taking place. No substantive correlations were found between observation-based and patients' subjective judgments. The observers' perspective on patient involvement needs to consider patient activities. Inconsistencies of patients' and observers' judgements concerning patient participation need further investigation. Copyright © 2012. Published by Elsevier GmbH.

Origins Space Telescope Concept 2: Trades, Decisions, and Study Status

NASA Astrophysics Data System (ADS)

Leisawitz, David; DiPirro, Michael; Carter, Ruth; Origins Space Telescope Decadal Mission Concept Study Team

2018-01-01

The Origins Space Telescope (OST) will trace the history of our cosmic origins from the time dust and heavy elements began to alter the astrophysical processes that shaped galaxies and enabled planets to form, culminating at least once in the development of a life-bearing planet. But how did the universe evolve in response to its changing ingredients, and how common are planets that support life? The OST, an advancing concept for the Far-Infrared Surveyor mission described in the NASA Astrophysics roadmap, is being designed to answer these questions. As envisaged in the Roadmap, Enduring Quests/Daring Visions, OST will offer sensitivity and spectroscopic capabilities that vastly exceed those found in any preceding far-IR observatory. The spectral range of OST was extended down to 6 microns to allow measurements of key biomarkers in transiting exoplanet spectra. Thus, OST is a mid- and far-IR mission. OST Concept 2 will inform the Science and Technology Definition Team’s understanding of the “solution space,” enabling a recommendation to the 2020 Decadal Survey which, while not fully optimized, will be scientifically compelling, executable, and intended to maximize the science return per dollar. OST Concept 1, described in a companion paper, would satisfy virtually all of the STDT’s science objectives in under 5 years. Concept 2 is intentionally less ambitious than Concept 1, but it still includes a 4 K telescope, enabling exquisitely sensitive far-IR measurements. This paper will summarize the architecture options considered for OST Concept 2 and describe the factors that led to the chosen design concept. Lessons from the Concept 1 study influenced our choices. We report progress on the Concept 2 study to date.

Europa Explorer Operational Scenarios Development

NASA Technical Reports Server (NTRS)

Lock, Robert E.; Pappalardo, Robert T.; Clark, Karla B.

2008-01-01

In 2007, NASA conducted four advanced mission concept studies for outer planets targets: Europa, Ganymede, Titan and Enceladus. The studies were conducted in close cooperation with the planetary science community. Of the four, the Europa Explorer Concept Study focused on refining mission options, science trades and implementation details for a potential flagship mission to Europa in the 2015 timeframe. A science definition team (SDT) was appointed by NASA to guide the study. A JPL-led engineering team worked closely with the science team to address 3 major focus areas: 1) credible cost estimates, 2) rationale and logical discussion of radiation risk and mitigation approaches, and 3) better definition and exploration of science operational scenario trade space. This paper will address the methods and results of the collaborative process used to develop Europa Explorer operations scenarios. Working in concert with the SDT, and in parallel with the SDT's development of a science value matrix, key mission capabilities and constraints were challenged by the science and engineering members of the team. Science goals were advanced and options were considered for observation scenarios. Data collection and return strategies were tested via simulation, and mission performance was estimated and balanced with flight and ground system resources and science priorities. The key to this successful collaboration was a concurrent development environment in which all stakeholders could rapidly assess the feasibility of strategies for their success in the full system context. Issues of science and instrument compatibility, system constraints, and mission opportunities were treated analytically and objectively leading to complementary strategies for observation and data return. Current plans are that this approach, as part of the system engineering process, will continue as the Europa Explorer Concept Study moves toward becoming a development project.

Space Station Systems Analysis Study. Volume 1: Executive summary, part 1 and 2

NASA Technical Reports Server (NTRS)

1977-01-01

The elements of space station programs required to support an operational base theme, a space laboratory theme, and advanced missions relatable to public needs/national interests are defined. Missions satisfying the foregoing requirements are identified, program scenarios/options are established. System options are evaluated for a selected number of program options. Subsystem analysis and programmatic comparisons are performed for selected primary concepts.

Space station needs, attributes and architectural options. Volume 4, attachment 1: Task 2 and 3 mission implementation and cost

NASA Technical Reports Server (NTRS)

1983-01-01

Mission scenario analysis and architectural concepts, alternative systems concepts, mission operations and architectural development, architectural analysis trades, evolution, configuration, and technology development are assessed.

Propulsion issues, options and trades

NASA Technical Reports Server (NTRS)

Forsythe, Doug J.

1986-01-01

Several different types of propulsion concepts are discussed: pulsed fission; continuous nuclear fission; chemical; and chemical boost with advanced nuclear fission. Some of the key characteristics of each type are provided, and typical concepts of each are shown.

Implementation of power barrier option valuation

NASA Astrophysics Data System (ADS)

Cahyani, Agatha C. P.; Sumarti, Novriana

2015-09-01

Options are financial instruments that can be utilized to reduce risk in stock investment. Barrier options are one of the major types of options actively used in financial markets where its life period depends on the path of the underlying stock prices. The features of the barrier option can be used to modify other types of options. In this research, the barrier option will be implemented into power option, so it is called power barrier option. This option is an extension of the vanilla barrier options where the Call payoff being considered is defined as P C =max (STβ-Kβ,0 ) , and the Put payoff being considered is defined as P P =max (Kβ-STβ,0 ) . Here β > 0 and β ≠ 1, K is the strike price of the option, and ST is the price of the underlying stock at time maturity T. In this paper, we generate the prices of stock using binomial method which is adjusted to the power option. In the conclusion, the price of American power barrier option is more expensive than the price of European power barrier option.

Patient-related and financial outcomes analysis of conventional full-arch rehabilitation versus the All-on-4 concept: a cohort study.

PubMed

Babbush, Charles A; Kanawati, Ali; Kotsakis, Georgios A; Hinrichs, James E

2014-04-01

Patient-related variables such as cost of treatment, length of the treatment period, and comfort provided by the interim prosthesis when treatment planning for full-arch rehabilitation are often neglected in dental publications. Two patient cohorts were followed up longitudinally in this study: the "All-on-4 treatment concept group" and the "historical group." The number of implants, total treatment time, number of surgical procedures, number of sinus grafts, necessity for immediate provisional implants, adjusted cost associated for treatment in each group, and the quality of interim prosthesis were compared. The total adjusted cost for patients receiving All-on-4 treatment concept averaged at $42,422 ± 3860 (&OV0556;31,392 ± 2856), whereas the mean total adjusted cost for the historical group was $57,944 ± 20,198 (&OV0556;42,879 ± 2113) (P = 0.01). The difference in cost had a mean value of $7307 (&OV0556;5407) per jaw. Factors associated with complexity of treatment and patient comfort, such as the quality of interim prosthesis, number of surgeries, and duration of treatment time, all significantly favored the All-on-4 treatment concept group in comparison with conventional treatment modalities. When implant rehabilitation of the total jaw is sought, the All-on-4 treatment concept should be considered the least costly and least time consuming treatment option.

Job Hunting in Tougher Times.

ERIC Educational Resources Information Center

Ross, Steven S.

1985-01-01

Several resources to consider are offered to ease the squeeze created by the computer market downturn. Areas addressed include: job-shop option; other-industries option; overseas option; graduate school option; entrepreneurial option; military option; job fairs; and weighing locations. Notes that colleges are looking for engineering teachers,…

Defining resilience within a risk-informed assessment framework

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coles, Garill A.; Unwin, Stephen D.; Holter, Gregory M.

2011-08-01

The concept of resilience is the subject of considerable discussion in academic, business, and governmental circles. The United States Department of Homeland Security for one has emphasised the need to consider resilience in safeguarding critical infrastructure and key resources. The concept of resilience is complex, multidimensional, and defined differently by different stakeholders. The authors contend that there is a benefit in moving from discussing resilience as an abstraction to defining resilience as a measurable characteristic of a system. This paper proposes defining resilience measures using elements of a traditional risk assessment framework to help clarify the concept of resilience andmore » as a way to provide non-traditional risk information. The authors show various, diverse dimensions of resilience can be quantitatively defined in a common risk assessment framework based on the concept of loss of service. This allows the comparison of options for improving the resilience of infrastructure and presents a means to perform cost-benefit analysis. This paper discusses definitions and key aspects of resilience, presents equations for the risk of loss of infrastructure function that incorporate four key aspects of resilience that could prevent or mitigate that loss, describes proposed resilience factor definitions based on those risk impacts, and provides an example that illustrates how resilience factors would be calculated using a hypothetical scenario.« less

Natural Conception May Be an Acceptable Option in HIV-Serodiscordant Couples in Resource Limited Settings.

PubMed

Sun, Lijun; Wang, Fang; Liu, An; Xin, Ruolei; Zhu, Yunxia; Li, Jianwei; Shao, Ying; Ye, Jiangzhu; Chen, Danqing; Li, Zaicun

2015-01-01

Many HIV serodiscordant couples have a strong desire to have their own biological children. Natural conception may be the only choice in some resource limited settings but data about natural conception is limited. Here, we reported our findings of natural conception in HIV serodiscordant couples. Between January 2008 and June 2014, we retrospectively collected data on 91 HIV serodiscordant couples presenting to Beijing Youan Hospital with childbearing desires. HIV counseling, effective ART on HIV infected partners, pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) in negative female partners and timed intercourse were used to maximally reduce the risk of HIV transmission. Of the 91 HIV serodiscordant couples, 43 were positive in male partners and 48 were positive in female partners. There were 196 unprotected vaginal intercourses, 100 natural conception and 97 newborns. There were no cases of HIV seroconversion in uninfected sexual partners. Natural conception may be an acceptable option in HIV-serodiscordant couples in resource limited settings if HIV-positive individuals have undetectable viremia on HAART, combined with HIV counseling, PrEP, PEP and timed intercourse.

Comparison of different target material options for the European Spallation Source based on certain aspects related to the final disposal

NASA Astrophysics Data System (ADS)

Kókai, Zsófia; Török, Szabina; Zagyvai, Péter; Kiselev, Daniela; Moormann, Rainer; Börcsök, Endre; Zanini, Luca; Takibayev, Alan; Muhrer, Günter; Bevilacqua, Riccardo; Janik, József

2018-02-01

Different target options have been examined for the European Spallation Source, which is under construction in Lund, Sweden. During the design update phase, parameters and characteristics for the target design have been optimized not only for neutronics but also with respect to the waste characteristics related to the final disposal of the target. A rotating, solid tungsten target was eventually selected as baseline concept; the other options considered included mercury and lead-bismuth (LBE) targets suitable for a pulsed source. Since the licensee is obliged to present a decommissioning plan even before the construction phase starts, the radioactive waste category of the target after full operation time is of crucial importance. The results obtained from a small survey among project partners of 7th Framework Program granted by EU 202247 contract have been used. Waste characteristics of different potential spallation target materials were compared. Based on waste index, the tungsten target is the best alternative and the second one is the mercury target. However, all alternatives have HLW category after a 10 year cooling. Based on heat generation alone all of the options would be below the HLW limit after this cooling period. The LBE is the least advantageous alternative based on waste index and heat generation comparison. These results can be useful in compiling the licensing documents of the ESS facility as the target alternatives can be compared from various aspects related to their disposal.

45 CFR 1306.31 - Choosing a Head Start program option.

Code of Federal Regulations, 2010 CFR

2010-10-01

... option must consider such factors as the child's age, developmental level, disabilities, health or learning problems, previous preschool experiences and family situation. Grantees must also consider parents...

45 CFR 1306.31 - Choosing a Head Start program option.

Code of Federal Regulations, 2011 CFR

2011-10-01

... option must consider such factors as the child's age, developmental level, disabilities, health or learning problems, previous preschool experiences and family situation. Grantees must also consider parents...

Strategies for the return of science data from in situ vehicles at Titan

NASA Astrophysics Data System (ADS)

Spilker, T. R.; Reh, K. R.; Erd, C.; Elliott, J. O.; Mohr, D.; Strange, N. J.

2009-04-01

Collaborative studies of the Titan Saturn System Mission (TSSM) in 2008 by ESA and NASA have included examination of strategies for optimizing the science return from that mission concept's proposed in situ elements. The current baselined mission concept calls for an orbiter provided and launched by NASA that would deliver to Titan and support two ESA-provided in situ elements, a lake lander whose science mission duration would be about nine hours, and a montgolfière (hot-air balloon) that would operate at ~10 km altitude in Titan's lower atmosphere for 6-12 months. This architecture has much in common with the highly successful Cassini-Huygens mission. The short-lived lake lander in particular would have a mission profile very similar to that of the Huygens probe, with all science data communications occurring while the NASA orbiter is relatively near Titan. Practical mission profile options for the montgolfière include extended periods when the NASA orbiter is farther from Titan, reducing data rates. Over long periods of time the montgolfière cannot be considered fixed over one location on Titan's surface, and in fact is expected to circumnavigate Titan in less than six months. Thus the schedule of communications windows between the in situ elements and the orbiter cannot be precisely determined far in advance, varying as the balloon literally "rides the wind". Other issues played critical roles in evaluating the many options available early in the studies. Some options for the timing of delivery of the in situ elements yielded more mass capability available for those elements, but their reduced data return due to orbit geometry outweighs the added mass capability. Another delivery option, delivery from Titan orbit, yields reduced delivery mass capability but was thought (before studies) to offer better data relay capability. Studies revealed that this strategy actually decreases the return from the lake lander as compared to options delivering the in situ elements from hyperbolic flybys. This presentation will describe options examined in the TSSM communications strategy studies. Particular attention is given to that chosen for the baseline strategy, with potential returned data volumes that provide generous margins over anticipated data requirements. Many of the results are not unique to Titan alone, but are applicable to in situ missions at any satellite of a giant planet. These collaborative studies were funded by, and performed under the cognizance of, NASA and ESA.

Proceedings: 1989 electric utility franchise conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romo, R.G.

The primary purpose of the Conference was to present and discuss strategic issues related to franchising electric service. The theme for the conference was to both improve the management of existing franchises and the negotiation of new franchises. To promote a better understanding of the planning issues related to this theme, the following sessions were designed: (1) public utility franchising, (2) investor owned utility and community perspectives on franchising, (3) franchise case study presentations, (4) alternatives to franchise renewal: the public acquisition option, and (5) special franchise issues. The Conference combined results from research coupled with actual franchise negotiating experiences,more » and concepts and ideas considered or implemented by utilities, government agencies, consultants and others.« less

Cognitive dissonance experienced by nurse practitioner faculty.

PubMed

Fontenot, Holly B; Hawkins, Joellen W; Weiss, Josie A

2012-08-01

The purpose of this study was to explicate the concept of cognitive dissonance as experienced and reported by nurse practitioner (NP) faculty members. Responses from NP faculty members to an online survey about their experiences with cognitive dissonance. The respondents detailed their experiences with cognitive dissonance, citing differences between expectations for which they are rewarded and those for which they are paid. Expecting all faculty members to excel in practice, research, teaching, and service may create unrealistic workloads for NP faculty members. Examining expectations and considering creation of a clinical track for faculty who practice may be options administrators of NP programs might explore. ©2012 The Author(s) Journal compilation ©2012 American Academy of Nurse Practitioners.

Space shuttle phase B extension, volume 1

NASA Technical Reports Server (NTRS)

1971-01-01

In order to define a system which would significantly reduce payload delivery costs, activities were extended to modifications of the reusable space shuttle design concept. Considered were systems using orbiters with external propellant tanks and an interim expendable booster which allowed phased development of the usable orbiter and booster. Analyzed were: Merits of internal and external propellant tanks and the impact of external LH2 compared to L02 and LH2; impact of cargo bay size; impact abort; merit of expendable booster options; and merit of a phased development program. Studies showed that external L02/LH2 and the continued use of the J-2S engine on the orbiter reduced program cost and risk.

Nuclear Thermal Propulsion Mars Mission Systems Analysis and Requirements Definition

NASA Technical Reports Server (NTRS)

Mulqueen, Jack; Chiroux, Robert C.; Thomas, Dan; Crane, Tracie

2007-01-01

This paper describes the Mars transportation vehicle design concepts developed by the Marshall Space Flight Center (MSFC) Advanced Concepts Office. These vehicle design concepts provide an indication of the most demanding and least demanding potential requirements for nuclear thermal propulsion systems for human Mars exploration missions from years 2025 to 2035. Vehicle concept options vary from large "all-up" vehicle configurations that would transport all of the elements for a Mars mission on one vehicle. to "split" mission vehicle configurations that would consist of separate smaller vehicles that would transport cargo elements and human crew elements to Mars separately. Parametric trades and sensitivity studies show NTP stage and engine design options that provide the best balanced set of metrics based on safety, reliability, performance, cost and mission objectives. Trade studies include the sensitivity of vehicle performance to nuclear engine characteristics such as thrust, specific impulse and nuclear reactor type. Tbe associated system requirements are aligned with the NASA Exploration Systems Mission Directorate (ESMD) Reference Mars mission as described in the Explorations Systems Architecture Study (ESAS) report. The focused trade studies include a detailed analysis of nuclear engine radiation shield requirements for human missions and analysis of nuclear thermal engine design options for the ESAS reference mission.

Evaluation of concepts for locomotive crew egress

DOT National Transportation Integrated Search

2003-03-01

This report presents the results of the first phase of a program to develop innovative concepts for a locomotive crew egress system. The program targeted rollover derailment accidents, where the options for crew egress are most limited. : In Phase I ...

Alternative approximation concepts for space frame synthesis

NASA Technical Reports Server (NTRS)

Lust, R. V.; Schmit, L. A.

1985-01-01

A structural synthesis methodology for the minimum mass design of 3-dimensionall frame-truss structures under multiple static loading conditions and subject to limits on displacements, rotations, stresses, local buckling, and element cross-sectional dimensions is presented. A variety of approximation concept options are employed to yield near optimum designs after no more than 10 structural analyses. Available options include: (A) formulation of the nonlinear mathematcal programming problem in either reciprocal section property (RSP) or cross-sectional dimension (CSD) space; (B) two alternative approximate problem structures in each design space; and (C) three distinct assumptions about element end-force variations. Fixed element, design element linking, and temporary constraint deletion features are also included. The solution of each approximate problem, in either its primal or dual form, is obtained using CONMIN, a feasible directions program. The frame-truss synthesis methodology is implemented in the COMPASS computer program and is used to solve a variety of problems. These problems were chosen so that, in addition to exercising the various approximation concepts options, the results could be compared with previously published work.

H-II Transfer Vehicle (HTV) and the Operations Concept for Extravehicular Activity (EVA) Hardware

NASA Technical Reports Server (NTRS)

Chullen, Cinda

2010-01-01

With the retirement of the Space Shuttle fleet imminent in 2011, a new concept of operations will become reality to meet the transportation challenges of the International Space Station (ISS). The planning associated with the retirement of the Space Shuttle has been underway since the announcement in 2004. Since then, several companies and government entities have had to look for innovative low-cost commercial orbital transportation systems to continue to achieve the objectives of ISS delivery requirements. Several options have been assessed and appear ready to meet the large and demanding delivery requirements of the ISS. Options that have been identified that can facilitate the challenge include the Russian Federal Space Agency's Soyuz and Progress spacecraft, European Space Agency's Automated Transfer Vehicle (ATV), the Japan Aerospace Exploration Agency's (JAXA's) H-II Transfer Vehicle (HTV) and the Boeing Delta IV Heavy (DIV-H). The newest of these options is the JAXA's HTV. This paper focuses on the HTV, mission architecture and operations concept for Extra-Vehicular Activities (EVA) hardware, the associated launch system, and details of the launch operations approach.

H-II Transfer Vehicle (HTV) and the Operations Concept for Extravehicular Activity (EVA) Hardware

NASA Technical Reports Server (NTRS)

Chullen, Cinda; Blome, Elizabeth; Tetsuya, Sakashita

2011-01-01

With the retirement of the Space Shuttle fleet imminent in 2011, a new operations concept will become reality to meet the transportation challenges of the International Space Station (ISS). The planning associated with the retirement of the Space Shuttle has been underway since the announcement in 2004. Since then, several companies and government entities have had to look for innovative low-cost commercial orbital transportation systems to continue to achieve the objectives of ISS delivery requirements. Several options have been assessed and appear ready to meet the large and demanding delivery requirements of the ISS. Options that have been identified that can facilitate the challenge include the Russian Federal Space Agency's Soyuz and Progress spacecraft, European Space Agency's Automated Transfer Vehicle (ATV), and the Japan Aerospace Exploration Agency's (JAXA s) H-II Transfer Vehicle (HTV). The newest of these options is the JAXA's HTV. This paper focuses on the HTV, mission architecture and operations concept for Extra-Vehicular Activities (EVA) hardware, the associated launch system, and details of the launch operations approach.

Advanced Space Transportation Program (ASTP)

NASA Image and Video Library

2000-04-03

This is a computer generated image of a Shuttle launch utilizing 2nd generation Reusable Launch Vehicle (RLV) flyback boosters, a futuristic concept that is currently undergoing study by NASA's Space Launch Initiative (SLI) Propulsion Office, managed by the Marshall Space Fight Center in Huntsville, Alabama, working in conjunction with the Agency's Glenn Research Center in Cleveland, Ohio. Currently, after providing thrust to the Space Shuttle, the solid rocket boosters are parachuted into the sea and are retrieved for reuse. The SLI is considering vehicle concepts that would fly first-stage boosters back to a designated landing site after separation from the orbital vehicle. These flyback boosters would be powered by several jet engines integrated into the booster capable of providing over 100,000 pounds of thrust. The study will determine the requirements for the engines, identify risk mitigation activities, and identify costs associated with risk mitigation and jet engine development and production, as well as determine candidate jet engine options to pursue for the flyback booster.

Satellite Power Systems /SPS/ - Overview of system studies and critical technology

NASA Technical Reports Server (NTRS)

Manson, S. V.

1980-01-01

Systems studies and critical technology issues for the development and evaluation of Satellite Power Systems (SPS) for the photovoltaic generation of electrical energy and its transmission to earth are reviewed. Initial concept studies completed in 1976 and system definition studies initiated in the same year have indicated the technical feasibility of SPS and identified challenging issues to be addressed as part of the SPS Concept Development and Evaluation Program. Systems considered in the study include photovoltaic and solar thermal power conversion configurations employing klystron or solid state microwave generators or lasers for power transmission, and power transmission options, system constructability and in-orbit and ground operations. Technology investigations are being performed in the areas of microwave power transmission, structure/controls interactions and the behavior of key materials in the space/SPS environment. Favorable results have been obtained in the areas of microwave phase distribution and phase control, dc-RF conversion, antenna radiating element, and no insurmountable problems have been discovered in any of the investigations to date.

Dynamic modelling and simulation of CSP plant based on supercritical carbon dioxide closed Brayton cycle

NASA Astrophysics Data System (ADS)

Hakkarainen, Elina; Sihvonen, Teemu; Lappalainen, Jari

2017-06-01

Supercritical carbon dioxide (sCO2) has recently gained a lot of interest as a working fluid in different power generation applications. For concentrated solar power (CSP) applications, sCO2 provides especially interesting option if it could be used both as the heat transfer fluid (HTF) in the solar field and as the working fluid in the power conversion unit. This work presents development of a dynamic model of CSP plant concept, in which sCO2 is used for extracting the solar heat in Linear Fresnel collector field, and directly applied as the working fluid in the recuperative Brayton cycle; these both in a single flow loop. We consider the dynamic model is capable to predict the system behavior in typical operational transients in a physically plausible way. The novel concept was tested through simulation cases under different weather conditions. The results suggest that the concept can be successfully controlled and operated in the supercritical region to generate electric power during the daytime, and perform start-up and shut down procedures in order to stay overnight in sub-critical conditions. Besides the normal daily operation, the control system was demonstrated to manage disturbances due to sudden irradiance changes.

On the path to 2025: understanding the Alzheimer's disease continuum.

PubMed

Aisen, Paul S; Cummings, Jeffrey; Jack, Clifford R; Morris, John C; Sperling, Reisa; Frölich, Lutz; Jones, Roy W; Dowsett, Sherie A; Matthews, Brandy R; Raskin, Joel; Scheltens, Philip; Dubois, Bruno

2017-08-09

Basic research advances in recent years have furthered our understanding of the natural history of Alzheimer's disease (AD). It is now recognized that pathophysiological changes begin many years prior to clinical manifestations of disease and the spectrum of AD spans from clinically asymptomatic to severely impaired. Defining AD purely by its clinical presentation is thus artificial and efforts have been made to recognize the disease based on both clinical and biomarker findings. Advances with biomarkers have also prompted a shift in how the disease is considered as a clinico-pathophysiological entity, with an increasing appreciation that AD should not only be viewed with discrete and defined clinical stages, but as a multifaceted process moving along a seamless continuum. Acknowledging this concept is critical to understanding the development process for disease-modifying therapies, and for initiating effective diagnostic and disease management options. In this article, we discuss the concept of a disease continuum from pathophysiological, biomarker, and clinical perspectives, and highlight the importance of considering AD as a continuum rather than discrete stages. While the pathophysiology of AD has still not been elucidated completely, there is ample evidence to support researchers and clinicians embracing the view of a disease continuum in their study, diagnosis, and management of the disease.

Liquid flyback booster pre-phase: A study assessment

NASA Technical Reports Server (NTRS)

Peterson, W.; Ankney, W.; Bell, J.; Berning, M.; Bryant, L.; Bufkin, A.; Cain, L.; Caram, J.; Cockrell, B.; Curry, D.

1994-01-01

The concept of a flyback booster has been around since early in the shuttle program. The original two-stage shuttle concepts used a manned flyback booster. These boosters were eliminated from the program for funding and size reasons. The current shuttle uses two Redesigned Solid Rocket Motors (RSRM's), which are recovered and refurbished after each flight; this is one of the major cost factors of the program. Replacement options have been studied over the past ten years. The conclusion reached by the most recent study is that the liquid flyback booster (LFBB) is the only competitive option from a life-cycle cost perspective. The purpose of this study was to assess the feasibility and practicality of LFBB's. The study provides an expansion of the recommendations made during the aforementioned study. The primary benefits are the potential for enhanced reusability and a reduction of recurring costs. The potential savings in vehicle turnaround could offset the up-front costs. Development of LFBB's requires a commitment to the shuttle program for 20 to 30 years. LFBB's also offer enhanced safety and abort capabilities. Currently, any failure of an RSRM can be considered catastrophic, since there are no intact abort capabilities during the burn of the RSRM's. The performance goal of the LFBB's was to lift a fully loaded orbiter under optimal conditions, so as not to be the limiting factor of the performance capability of the shuttle. In addition, a final benefit is the availability of growth paths for applications other than shuttle.

Liquid Flyback Booster Pre-Phase A Study Assessment. Volume 1

NASA Technical Reports Server (NTRS)

Peterson, W.; Ankney, W.; Bell, J.; Berning, M.; Bryant, L.; Bufkin, A.; Cain, L.; Caram, J.; Cockrell, B.; Curry, D.;

Organizational Design within University Extension Units: Some Concepts, Options, and Guidelines

ERIC Educational Resources Information Center

Baker, Harold R.

1976-01-01

Drawing on the behavioral sciences, the author outlines alternative modes of structuring and organizing an extension unit. The advantages and disadvantages of several organizational design options, the purposes and management of the temporary task force, and some general guidelines for making organizational design decisions are discussed.…

78 FR 10249 - Environmental Impact Statement: Will and Kankakee Counties, IL and Lake County, IN

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-13

... design concepts. Alternatives to be evaluated will include (1) taking no action and (2) evaluating... design issues in a way that does not materially increase overall impacts. The primary environmental... or design options within the selected corridor, financing options, and construction sequencing...

The space station power system

NASA Technical Reports Server (NTRS)

1989-01-01

The requirements for electrical power by the proposed Space Station Freedom are discussed. The options currently under consideration are examined. The three power options are photovoltaic, solar dynamic, and a hybrid system. Advantages and disadvantages of each system are tabulated. Drawings and artist concepts of the Space Station configuration are provided.

Using Newborn Screening Bloodspots for Research: Public Preferences for Policy Options.

PubMed

Hayeems, Robin Z; Miller, Fiona A; Barg, Carolyn J; Bombard, Yvonne; Cressman, Celine; Painter-Main, Michael; Wilson, Brenda; Little, Julian; Allanson, Judith; Avard, Denise; Giguere, Yves; Chakraborty, Pranesh; Carroll, June C

2016-06-01

Retaining residual newborn screening (NBS) bloodspots for medical research remains contentious. To inform this debate, we sought to understand public preferences for, and reasons for preferring, alternative policy options. We assessed preferences among 4 policy options for research use of residual bloodspots through a bilingual national Internet survey of a representative sample of Canadians. Fifty percent of respondents were randomly assigned to select reasons supporting these preferences. Understanding of and attitudes toward screening and research concepts, and demographics were assessed. Of 1102 respondents (94% participation rate; 47% completion rate), the overall preference among policy options was ask permission (67%); this option was also the most acceptable choice (80%). Assume permission was acceptable to 46%, no permission required was acceptable to 29%, and no research allowed was acceptable to 26%. The acceptability of the ask permission option was reduced among participants assigned to the reasoning exercise (84% vs 76%; P = .004). Compared with assume/no permission required, ordered logistic regression showed a significant reduction in preference for the ask permission option with greater understanding of concepts (odds ratio, 0.87; P < .001), greater confidence in science (odds ratio, 0.16; P < .001), and a perceived responsibility to contribute to research (odds ratio, 0.39; P < .001). Surveyed Canadians prefer that explicit permission is sought for storage and research use of NBS bloodspots. This preference was diminished when reasons supporting and opposing routine storage, and other policy options, were presented. Findings warrant consideration as NBS communities strategize to respond to shifting legislative contexts. Copyright © 2016 by the American Academy of Pediatrics.

Designing flexible engineering systems utilizing embedded architecture options

NASA Astrophysics Data System (ADS)

Pierce, Jeff G.

This dissertation develops and applies an integrated framework for embedding flexibility in an engineered system architecture. Systems are constantly faced with unpredictability in the operational environment, threats from competing systems, obsolescence of technology, and general uncertainty in future system demands. Current systems engineering and risk management practices have focused almost exclusively on mitigating or preventing the negative consequences of uncertainty. This research recognizes that high uncertainty also presents an opportunity to design systems that can flexibly respond to changing requirements and capture additional value throughout the design life. There does not exist however a formalized approach to designing appropriately flexible systems. This research develops a three stage integrated flexibility framework based on the concept of architecture options embedded in the system design. Stage One defines an eight step systems engineering process to identify candidate architecture options. This process encapsulates the operational uncertainty though scenario development, traces new functional requirements to the affected design variables, and clusters the variables most sensitive to change. The resulting clusters can generate insight into the most promising regions in the architecture to embed flexibility in the form of architecture options. Stage Two develops a quantitative option valuation technique, grounded in real options theory, which is able to value embedded architecture options that exhibit variable expiration behavior. Stage Three proposes a portfolio optimization algorithm, for both discrete and continuous options, to select the optimal subset of architecture options, subject to budget and risk constraints. Finally, the feasibility, extensibility and limitations of the framework are assessed by its application to a reconnaissance satellite system development problem. Detailed technical data, performance models, and cost estimates were compiled for the Tactical Imaging Constellation Architecture Study and leveraged to complete a realistic proof-of-concept.

Centralized vs decentralized lunar power system study

NASA Astrophysics Data System (ADS)

Metcalf, Kenneth; Harty, Richard B.; Perronne, Gerald E.

1991-09-01

Three power-system options are considered with respect to utilization on a lunar base: the fully centralized option, the fully decentralized option, and a hybrid comprising features of the first two options. Power source, power conditioning, and power transmission are considered separately, and each architecture option is examined with ac and dc distribution, high and low voltage transmission, and buried and suspended cables. Assessments are made on the basis of mass, technological complexity, cost, reliability, and installation complexity, however, a preferred power-system architecture is not proposed. Preferred options include transmission based on ac, transmission voltages of 2000-7000 V with buried high-voltage lines and suspended low-voltage lines. Assessments of the total cost associated with the installations are required to determine the most suitable power system.

Utilising integrated urban water management to assess the viability of decentralised water solutions.

PubMed

Burn, Stewart; Maheepala, Shiroma; Sharma, Ashok

2012-01-01

Cities worldwide are challenged by a number of urban water issues associated with climate change, population growth and the associated water scarcity, wastewater flows and stormwater run-off. To address these problems decentralised solutions are increasingly being considered by water authorities, and integrated urban water management (IUWM) has emerged as a potential solution to most of these urban water challenges, and as the key to providing solutions incorporating decentralised concepts at a city wide scale. To incorporate decentralised options, there is a need to understand their performance and their impact on a city's total water cycle under alternative water and land management options. This includes changes to flow, nutrient and sediment regimes, energy use, greenhouse gas emissions, and the impacts on rivers, aquifers and estuaries. Application of the IUWM approach to large cities demands revisiting the fundamental role of water system design in sustainable city development. This paper uses the extended urban metabolism model (EUMM) to expand a logical definition for the aims of IUWM, and discusses the role of decentralised systems in IUWM and how IUWM principles can be incorporated into urban water planning.

Theory of Financial Risk and Derivative Pricing

NASA Astrophysics Data System (ADS)

Bouchaud, Jean-Philippe; Potters, Marc

2009-01-01

Foreword; Preface; 1. Probability theory: basic notions; 2. Maximum and addition of random variables; 3. Continuous time limit, Ito calculus and path integrals; 4. Analysis of empirical data; 5. Financial products and financial markets; 6. Statistics of real prices: basic results; 7. Non-linear correlations and volatility fluctuations; 8. Skewness and price-volatility correlations; 9. Cross-correlations; 10. Risk measures; 11. Extreme correlations and variety; 12. Optimal portfolios; 13. Futures and options: fundamental concepts; 14. Options: hedging and residual risk; 15. Options: the role of drift and correlations; 16. Options: the Black and Scholes model; 17. Options: some more specific problems; 18. Options: minimum variance Monte-Carlo; 19. The yield curve; 20. Simple mechanisms for anomalous price statistics; Index of most important symbols; Index.

Theory of Financial Risk and Derivative Pricing - 2nd Edition

NASA Astrophysics Data System (ADS)

Bouchaud, Jean-Philippe; Potters, Marc

2003-12-01

Foreword; Preface; 1. Probability theory: basic notions; 2. Maximum and addition of random variables; 3. Continuous time limit, Ito calculus and path integrals; 4. Analysis of empirical data; 5. Financial products and financial markets; 6. Statistics of real prices: basic results; 7. Non-linear correlations and volatility fluctuations; 8. Skewness and price-volatility correlations; 9. Cross-correlations; 10. Risk measures; 11. Extreme correlations and variety; 12. Optimal portfolios; 13. Futures and options: fundamental concepts; 14. Options: hedging and residual risk; 15. Options: the role of drift and correlations; 16. Options: the Black and Scholes model; 17. Options: some more specific problems; 18. Options: minimum variance Monte-Carlo; 19. The yield curve; 20. Simple mechanisms for anomalous price statistics; Index of most important symbols; Index.

A System Dynamics Approach for the Selection of Contaminated Land Management Options

NASA Astrophysics Data System (ADS)

McKnight, U. S.; Kuebert, M.; Finkel, M.; Bieg, M.

2006-12-01

Large-scale contaminated land and groundwater is a widespread problem that can severely impact human health, the environment and the economy at many urban sites all over the world. Usually a considerable number of potential management solutions exist at each of these sites. A detailed investigation of all these options, however, is not economically feasible which makes streamlining of the planning and decision process a mandatory requirement. Decisions to be taken should be made as early as possible in order to reduce expenditures on site investigation. Therefore, a tiered decision-making procedure is required, including (i) identification and prioritization of focal areas of risks, (ii) feasibility screening of remediation targets and available management alternatives to narrow the range of possible options for (iii) subsequent detailed investigations of only a select group of preferable options. For each of these elements, tailored decision and investigation concepts are required. These concepts and applied methods should be specifically adapted to the type and scale of the particular decision to be taken- more target-oriented, cost-efficient investigation programs, as well as model-based assessment methods are needed (Ruegner et al. 2006). A gap exists within this framework with respect to preliminary assessment methodologies representing the first decision level. To fill this gap, a new system dynamics approach has been developed that represents the system of source- pathway-receptor sequences by means of a mass flux model. The dynamics are governed by the effects of possible remedial actions, which are described as mass flux change over time (Serapiglia et al. 2005). This approach has been implemented in the preliminary evaluation tool CARO-plus (Cost-efficiency Assessment of Remediation Options) that models the effects of potential remedial actions, including tackling the contaminant source and managing the groundwater plume. The model represents the causal relationships that exist between the state of the system, the effects of the technologies and their costs, and may considerably impact the outcome to be predicted. The tool enables a fast and effective "screening" of management scenarios using simplified approaches (analytical models). Replacing the concept of total cleanup of sites based on concentration standards, the evaluation tool contains risk modules that describe exposure pathways, i.e. transfer of contaminants from groundwater to the receptor "human being", in accordance to MEPAS (Strenge & Chamberlain 1995). As multiple lines of evidence may apply, the effects of remediation options can be analyzed on the basis of contaminant mass flux, concentrations, and/or risk indices (carcinogenic/noncarcinogenic). Costs are calculated in terms of net present values. Uncertainty is taken into account using Monte-Carlo sensitivity analyses. In the presentation, examples will be shown for how the proposed approach helps to pre-select compatible remediation options by giving an overview to the following set of questions: (i) what is the time scale for risks expected at a particular site, (ii) does the scenario reduce/control risk at the receptor, (iii) is the scenario compatible with cleanup objectives (e.g. in the case that concentration standards are still required for specific compounds present at a site), (iv) does the scenario satisfy cost objectives and can therefore be considered financially viable, (v) is the scenario acceptable to regulators and the community, and (vi) what factors are most critical to the decision-making process.

The Europa Clipper Mission Concept

NASA Astrophysics Data System (ADS)

Pappalardo, Robert; Goldstein, Barry; Magner, Thomas; Prockter, Louise; Senske, David; Paczkowski, Brian; Cooke, Brian; Vance, Steve; Wes Patterson, G.; Craft, Kate

2014-05-01

A NASA-appointed Science Definition Team (SDT), working closely with a technical team from the Jet Propulsion Laboratory (JPL) and the Applied Physics Laboratory (APL), recently considered options for a future strategic mission to Europa, with the stated science goal: Explore Europa to investigate its habitability. The group considered several mission options, which were fully technically developed, then costed and reviewed by technical review boards and planetary science community groups. There was strong convergence on a favored architecture consisting of a spacecraft in Jupiter orbit making many close flybys of Europa, concentrating on remote sensing to explore the moon. Innovative mission design would use gravitational perturbations of the spacecraft trajectory to permit flybys at a wide variety of latitudes and longitudes, enabling globally distributed regional coverage of the moon's surface, with nominally 45 close flybys at altitudes from 25 to 100 km. We will present the science and reconnaissance goals and objectives, a mission design overview, and the notional spacecraft for this concept, which has become known as the Europa Clipper. The Europa Clipper concept provides a cost-efficient means to explore Europa and investigate its habitability, through understanding the satellite's ice and ocean, composition, and geology. The set of investigations derived from the Europa Clipper science objectives traces to a notional payload for science, consisting of: Ice Penetrating Radar (for sounding of ice-water interfaces within and beneath the ice shell), Topographical Imager (for stereo imaging of the surface), ShortWave Infrared Spectrometer (for surface composition), Neutral Mass Spectrometer (for atmospheric composition), Magnetometer and Langmuir Probes (for inferring the satellite's induction field to characterize an ocean), and Gravity Science (to confirm an ocean).The mission would also include the capability to perform reconnaissance for a future lander, with the Reconnaissance goal: Characterize safe and scientifically compelling sites for a future lander mission to Europa. To accomplish these reconnaissance objectives and the investigations that flow from them, principally to address issues of landing site safety, two additional instruments would be included in the notional payload: a Reconnaissance Camera (for high-resolution imaging) and a Thermal Imager (to characterize the surface through its thermal properties). These instruments, in tandem with the notional payload for science, could assess the science value of potential landing sites. This notional payload serves as a proof-of-concept for the Europa Clipper during its formulation stage. The actual payload would be chosen through a NASA Announcement of Opportunity. If NASA were to proceed with the mission, it could be possible to launch early in the coming decade, on an Atlas V or the Space Launch System (SLS).

What weight loss treatment options do geriatric patients with overweight and obesity want to consider?

PubMed

MacMillan, M; Cummins, K; Fujioka, K

2016-12-01

Since the 1990s, a number of weight loss medications have been removed from the USA and or European market because of adverse events associated with these medications. These medications include fenfluramine (heart valve thickening), sibutramine (cardiovascular risk) and rimonabant (depression). This history may affect a patient's desire to consider weight loss medications as an option for weight management. This descriptive study was designed to observe what treatment options the geriatric patient (age 65 or higher) seeking weight loss would like to consider, as well as the reasons they felt they struggled with overweight or obesity. A questionnaire was given to 102 geriatric patients with overweight or obesity before starting a weight loss programme at a weight management centre. The questionnaire asked the patient why they felt they were overweight or obese and what treatment options they wished to consider. The geriatric patients were matched with younger patients in body mass index and sex. The three most common perceptions that geriatric patients felt were causes of their increased weight were 'lack of exercise' (76.2%), 'poor food choices' (59.4%) and 'cravings' (47.5%). When geriatric patients were asked what treatment options they would like to discuss, the four most common options requested were 'diet and healthy eating' (67.3%), weight loss medications (57.4%), a request for a 'metabolic work up' (55.4%) and 'exercise' (53.5%). These responses were no different from their younger cohorts. When geriatric patients with a body mass index of 35 or higher were given bariatric surgery as a treatment option, 21.9% marked it as a treatment option they would like to consider. Over half of geriatric patients desired to discuss weight loss medications as a treatment option. Diet and exercise were also of strong interest, which is in line with current weight management guidelines.

A Survey of Titan Balloon Concepts and Technology Status

NASA Technical Reports Server (NTRS)

Hall, Jeffery L.

2011-01-01

This paper surveys the options for, and technology status of, balloon vehicles to explore Saturn's moon Titan. A significant amount of Titan balloon concept thinking and technology development has been performed in recent years, particularly following the spectacular results from the descent and landing of the Huygens probe and remote sensing observations by the Cassini spacecraft. There is widespread recognition that a balloon vehicle on the next Titan mission could provide an outstanding and unmatched capability for in situ exploration on a global scale. The rich variety of revealed science targets has combined with a highly favorable Titan flight environment to yield a wide diversity of proposed balloon concepts. The paper presents a conceptual framework for thinking about balloon vehicle design choices and uses it to analyze various Titan options. The result is a list of recommended Titan balloon vehicle concepts that could perform a variety of science missions, along with their projected performance metrics. Recent technology developments for these balloon concepts are discussed to provide context for an assessment of outstanding risk areas and technological maturity. The paper concludes with suggestions for technology investments needed to achieve flight readiness.

Space industrialization. Volume 3: Space industrialization implementation concepts

NASA Technical Reports Server (NTRS)

1978-01-01

Methods for selecting the most viable program options were examined along with techniques for hardware development. Several separate program options were defined, and future plans for space exploitation were reviewed. Hardware elements in various sectors of space are discussed in detail to provide a definition for the major functional elements and operations.

78 FR 6382 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing and Immediate...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

... shares other than 100.\\8\\ Moreover, the concept of listing and trading parallel options products of... terms of the Options Disclosure Document. With regard to the impact of this proposal on system capacity... Authority (``OPRA'') have the necessary systems capacity to handle the potential additional traffic...

78 FR 6391 - Self-Regulatory Organizations; NASDAQ OMX BX, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

... shares other than 100.\\8\\ Moreover, the concept of listing and trading parallel options products of... system capacity, the Exchange has analyzed its capacity and represents that it and the Options Price Reporting Authority (``OPRA'') have the necessary systems capacity to handle the potential additional...

Investigation of lunar base thermal control system options

NASA Technical Reports Server (NTRS)

Ewart, Michael K.

1993-01-01

Long duration human exploration missions to the Moon will require active thermal control systems which have not previously been used in space. The two technologies which are most promising for long term lunar base thermal control are heat pumps and radiator shades. Recent trade-off studies at the Johnson Space Center have focused development efforts on the most promising heat pump and radiator shade technologies. Since these technologies are in the early stages of development and many parameters used in the study are not well defined, a parametric study was done to test the sensitivity to each assumption. The primary comparison factor in these studies was the total mass system, with power requirements included in the form of a mass penalty for power. Heat pump technologies considered were thermally driven heat pumps such as metal hydride, complex compound, absorption and zeolite. Also considered were electrically driven Stirling and vapor compression heat pumps. Radiator shade concepts considered included step shaped, V-shaped and parabolic (or catenary) shades and ground covers. A further trade study compared the masses of heat pump and radiator shade systems.

Back to the future? Views of heads of schools of nursing about undergraduate specialization in mental health nursing.

PubMed

Happell, Brenda; McAllister, Margaret

2014-12-01

Preparation of nursing students for practice in mental health settings in Australia has been criticized since comprehensive education replaced preregistration specialist education. Current and projected workforce shortages have given rise to considering the reintroduction of specialization at preregistration level as a potential solution. Support of heads of schools of nursing would be essential for such an initiative to be considered. A qualitative exploratory study was undertaken involving in-depth telephone interviews with heads of schools of nursing in Queensland. Participants generally favoured the concept of specialization in mental health nursing at undergraduate level. Data analysis revealed the following themes: meeting workforce needs, improving quality of care, employability of graduates, an attractive option for students, and what would have to go. Participants identified many benefits to mental health service delivery and consumer outcomes. How the initiative could be developed within an already overcrowded curriculum was identified as the major barrier. This level of support is encouraging if necessary changes to the educational preparation for mental health nursing practice are to be considered. © 2014 Australian College of Mental Health Nurses Inc.

Managing a Special Library. Parts I and II.

ERIC Educational Resources Information Center

Labovitz, Judy; Swanigan, Meryl

1985-01-01

Various concepts from "In Search of Excellence" are described in context of authors' personal styles. Discussions address thinking in terms of options, using statistics, learning value of corporate politics, a bias toward action, productivity through people, the "lean-machine" concept, staying close to client, entrepreneurship…

Voluntary Simplicity: A Lifestyle Option.

ERIC Educational Resources Information Center

Pestle, Ruth E.

This guide provides practical ideas for incorporating the concept of voluntary simplicity into home economics classes. Discussed in the first chapter are the need to study voluntary simplicity, its potential contributions to home economics, and techniques and a questionnaire for measuring student attitudes toward the concept. The remaining…

41 CFR 102-73.130 - When may Federal agencies consider acquiring leases with purchase options?

Code of Federal Regulations, 2010 CFR

2010-07-01

... consider leasing with a purchase option at or below fair market value, consistent with the lease-purchase... and other advantages to the Government and is consistent with the Government's goals. (b) The...

Fuel cell adventures. Dynamics of a technological community in a quasi-market of technological options

NASA Astrophysics Data System (ADS)

Schaeffer, G. J.; Uyterlinde, M. A.

In this paper some insights from a social science perspective in the dynamics of the fuel cell community will be provided. An important concept used in the analysis is that of a `quasi'-market of technological options. The strategic choices of actors for certain technological options can be regarded as analogous to choices of consumers made on a market. A scientometric research approach has been used to investigate the aggregate effects of this and other variations of strategic behaviour. These concepts and analyses are shown to be helpful in answering questions such as why fuel cells are so popular today whereas they have not always been, and why preferences for different types of fuel cells shift over time. At the end of the paper the relevance of these kind of analyses for technology forecasting and management practices is briefly discussed.

[Achilles tendon rupture : Current diagnostic and therapeutic standards].

PubMed

Hertel, G; Götz, J; Grifka, J; Willers, J

2016-08-01

A superior life expectancy and an increased activity in the population result in an increase in degenerative diseases, such as Achilles tendon ruptures. The medical history and physical examinations are the methods of choice to diagnose Achilles tendon ruptures. Ultrasound and radiography represent reasonable extended diagnostic procedures. In order to decide on the medical indications for the therapy concept, the advantages and disadvantages of conservative and surgical treatment options have to be weighed up on an indivdual basis. There are explicit contraindications for both treatment options. For the surgical treatment concept open suture techniques, minimally invasive methods and reconstructive procedures are available. The postoperative management of the patient is as important as the choice of surgical technique. With the correct medical indications and supervision of the patient it is possible to achieve extremely satisfying results for the patient with both conservative and surgical treatment options.

NASA electrothermal auxiliary propulsion technology

NASA Technical Reports Server (NTRS)

Stone, J. R.

1986-01-01

Electrothermal auxiliary propulsion systems provide high performance options which can have major mission benefits. There are several electrothermal concepts which offer a range of characteristics and benefits. Resistojets are the highest thrust to power option and are currently operational at mission average values of specific impulse, I sub sp approximately 295 sec. Long life, multipropellant resistojets are being developed for the space station, and resistojet technology advancements are being pursued to improve the I sub sp by more than 20 percent for resistojets used in satellite applications. Direct current arcjets have the potential of I sub sp over 400 sec with storable propellants and should provide over 1000 sec with hydrogen. Advanced concepts are being investigated to provide high power density options and possible growth to primary propulsion applications. Broad based experimental and analytical research and technology programs of NASA are summarized and recent significant advances are reviewed.

26 CFR 1.544-4 - Options.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Options. 1.544-4 Section 1.544-4 Internal Revenue... (CONTINUED) Personal Holding Companies § 1.544-4 Options. The shares of stock which may be acquired by reason of an option shall be considered to be constructively owned by the individual having the option to...

Worldwide advanced nuclear power reactors with passive and inherent safety: What, why, how, and who

DOE Office of Scientific and Technical Information (OSTI.GOV)

Forsberg, C.W.; Reich, W.J.

1991-09-01

The political controversy over nuclear power, the accidents at Three Mile Island (TMI) and Chernobyl, international competition, concerns about the carbon dioxide greenhouse effect and technical breakthroughs have resulted in a segment of the nuclear industry examining power reactor concepts with PRIME safety characteristics. PRIME is an acronym for Passive safety, Resilience, Inherent safety, Malevolence resistance, and Extended time after initiation of an accident for external help. The basic ideal of PRIME is to develop power reactors in which operator error, internal sabotage, or external assault do not cause a significant release of radioactivity to the environment. Several PRIME reactormore » concepts are being considered. In each case, an existing, proven power reactor technology is combined with radical innovations in selected plant components and in the safety philosophy. The Process Inherent Ultimate Safety (PIUS) reactor is a modified pressurized-water reactor, the Modular High Temperature Gas-Cooled Reactor (MHTGR) is a modified gas-cooled reactor, and the Advanced CANDU Project is a modified heavy-water reactor. In addition to the reactor concepts, there is parallel work on super containments. The objective is the development of a passive box'' that can contain radioactivity in the event of any type of accident. This report briefly examines: why a segment of the nuclear power community is taking this new direction, how it differs from earlier directions, and what technical options are being considered. A more detailed description of which countries and reactor vendors have undertaken activities follows. 41 refs.« less

The Bobath (NDT) concept in adult neurological rehabilitation: what is the state of the knowledge? A scoping review. Part II: intervention studies perspectives.

PubMed

Vaughan-Graham, Julie; Cott, Cheryl; Wright, F Virginia

2015-01-01

The study's purpose was to describe the range of knowledge pertaining to the Bobath (NDT) concept in adult neurological rehabilitation, synthesizes the findings, identify knowledge gaps and develop empirically based recommendations for future research. A scoping review of research and non-research articles published from 2007 to 2012. Two independent reviewers selected studies based on a systematic procedure. Inclusion criteria for studies were electronically accessible English language literature with Bobath and/or Neurodevelopmental Therapy as the subject heading in the title/keyword/abstract/intervention comparison with respect to adult neurological conditions. Data were abstracted and summarized with respect to study design, theoretical framework, clinical application including population representation, study fidelity, intervention comparison, duration of care, measurement and findings. Of the 33 publications identified 17 were intervention studies (11 RCT's/1 prospective parallel group design/5 N-of-1). One other paper was a systematic review. The intervention studies, primarily RCT designs, have serious methodological concerns particularly related to study/treatment fidelity and measurement resulting in no clear clinical direction. Aspects such as theoretical framework, therapist skill, quality of movement measurement and individualized interventions require careful consideration in the design of Bobath studies. Implications for Rehabilitation Future intervention studies should be based on the current Bobath theoretical framework and key aspects of clinical practice. Study and treatment fidelity issues need to be carefully considered when interpreting the results of existing RCT's evaluating the Bobath concept. N-of-1 randomized, observational, factorial and mixed method study designs should be considered as alternative study options.

75 FR 17412 - Cancer Therapy Evaluation Program Intellectual Property Option to Collaborator

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-06

... Program Intellectual Property Option to Collaborator AGENCY: National Cancer Institute (NCI), National... Evaluation Program (CTEP) INTELLECTUAL PROPERTY OPTION. The proposed policy, if finalized, would establish... recommended Intellectual Property Option and Institution Notification if they wish to be considered for...

[Head and neck paragangliomas: An interdisciplinary challenge].

PubMed

Künzel, J; Bahr, K; Hainz, M; Rossmann, H; Matthias, C

2015-12-01

Current treatment strategies for head and neck paragangliomas are moving away from radical resection and toward surgical tumor reduction, in order to preserve function and reduce morbidity. Radiotherapy modalities are alternative primary treatment options. A PubMed search of the relevant literature on genetics and treatment of head and neck paragangliomas was conducted. The rapid progress made in genetic research was mainly triggered by two factors: firstly, the establishment of central registries for paraganglioma patients and secondly, the availability of next-generation sequencing methods. Exome sequencing and a gene-panel sequencing approach have already been successfully applied to paraganglioma syndromes. The latter method in particular is rapid and cost-effective, and may soon replace complex genotyping algorithms. The literature provides good evidence that diversified modern treatment options are available to realize individual treatment concepts for almost all paraganglioma manifestations. Generally, small and symptomatic tumors should be completely resected, particularly in younger patients. Considering the patient's age, symptoms, morbidity risk, and comorbidities, larger tumors should be surgically treated in a function-preserving manner. In these cases, primary radiotherapy is an equivalent alternative option. A "wait and scan" strategy is possible in selected cases. The potential morbidity of surgical treatment must be weighed against the expectable quality of life. Comprehensive consultation with the patient about possible treatment modalities is mandatory. Treatment decision making should involve a multidisciplinary team of experts.

Applying the OTV to lunar logistics

NASA Technical Reports Server (NTRS)

Willcockson, W. H.

1988-01-01

The Orbit Transfer Vehicle (OTV), representing the next generation of upper stages, has recently been studied in a Phase A concept definition study managed by NASA's Marshall Space Flight Center. The vehicle has been previously defined as strictly an orbit-to-orbit type transfer device. Recently its application to the task of lunar surface logistics was investigated. Transfer options to the surface were considered which included direct transfer, and transfer via lunar orbit as well as the L1 libration point. The subsystem modifications required to enable lunar landings were established for the following elements: aerobrake, main propulsion system, landing legs, primary structure, and avionics. It is concluded that the majority of the basic systems required for efficient transfer to the lunar surface are already contained in the OTV.

Design and operation of a Loran-C time reference station

NASA Technical Reports Server (NTRS)

Putkovich, K.

1974-01-01

Some of the practical questions that arise when one decides to use Loran-C in a time reference system are explored. An extensive effort is made to provide basic, practical information on establishing and operating a reference station. Four areas were covered: (1) the design, configuration and operational concepts which should be considered prior to establishing and operating a reference station using Loran-C, (2) the options and tradeoffs available regarding capabilities, cost, size, versatility, ease of operation, etc., that are available to the designer, (3) what measurements are made, how they are made and what they mean, and (4) the experience the U.S. Naval Observatory Time Service Division has had in the design and operation of such stations.

Evaluating the prospects for sustainable energy development in a sample of Chinese villages.

PubMed

Mortimer, Nigel D; Grant, John F

2008-04-01

This paper describes the methods used to evaluate the potential for achieving sustainable energy development in six Chinese villages included in the Sustainable Users' Concepts for China Engaging Scientific Scenarios (SUCCESS) Project by examining energy efficiency potential and local renewable energy prospects. The approaches needed to obtain and analyse information on possible energy efficiency measures and renewable energy resources are summarised. Results are presented in terms of cumulative net savings in primary energy consumption, as an indicator of energy resource depletion, and associated carbon dioxide emissions, as an indicator of global climate change. Options for sustainable energy development are ranked in order of likely implementation and practical actions which could be considered in each village are identified.

Amelogenesis imperfecta: review of diagnostic findings and treatment concepts.

PubMed

Sabandal, Martin M I; Schäfer, Edgar

2016-09-01

Mineralization defects like amelogenesis imperfecta are often of hereditary origin. This article reviews the diagnostic findings and summarizes the suggested treatment approaches. Currently, there are no defined therapy recommendations available for patients suffering from amelogenesis imperfecta. The mentioned therapies are more or less equal but no comprehensive therapy recommendation is evident. When treating patients suffering from amelogenesis imperfecta, a comprehensive therapy of almost every dental discipline has to be considered. The earlier the diagnosis of amelogenesis imperfecta is confirmed, the better the outcome is. Optimal treatment approaches consist of early diagnosis and treatment approach and frequent dental recall appointments to prevent progressive occlusal wear or early destruction by caries. Full-mouth prosthetic treatment seems to be the best treatment option.

Operations planning for Space Station Freedom - And beyond

NASA Technical Reports Server (NTRS)

Gibson, Stephen S.; Martin, Thomas E.; Durham, H. J.

1992-01-01

The potential of automated planning and electronic execution systems for enhancing operations on board Space Station Freedom (SSF) are discussed. To exploit this potential the Operations Planning and Scheduling Subsystem is being developed at the NASA Johnson Space Center. Such systems may also make valuable contributions to the operation of resource-constrained, long-duration space habitats of the future. Points that should be considered during the design of future long-duration manned space missions are discussed. Early development of a detailed operations concept as an end-to-end mission description offers a basis for iterative design evaluation, refinement, and option comparison, particularly when used with an advanced operations planning system capable of modeling the operations and resource constraints of the proposed designs.

The tobacco endgame: a qualitative review and synthesis

PubMed Central

McDaniel, Patricia A; Smith, Elizabeth A; Malone, Ruth E

2016-01-01

The tobacco endgame concept reorients discussion away from the persistent control of tobacco toward plans for ending the tobacco epidemic, and envisions a tobacco-free future. A variety of policy approaches have been proposed, with many offered prior to the introduction of the unifying term ‘endgame’. We conducted a qualitative synthesis of the literature on tobacco control endgames, and drew on media accounts and discussion of analogous ideas for illustrative purposes. We identified proposals focused on the product, user, market/supply or larger institutional structures. Research on public support for these proposals was limited, but suggestive of some public appetite for endgame ideas. Advocates should be encouraged to explore new policy options and consider the goal of a tobacco-free future. PMID:26320149

The "Kiel Concept" of Long-Term Administration of Daily Low-Dose Sildenafil Initiated in the Immediate Post-Prostatectomy Period: Evaluation and Comparison With the International Literature on Penile Rehabilitation.

PubMed

Osmonov, Daniar K; Jünemann, Klaus P; Bannowsky, Andreas

2017-07-01

Radical prostatectomy (RP) is the most common definitive invasive treatment option for localized prostate cancer. Although the different surgical procedures-open RP, laparoscopic RP, and robot-assisted laparoscopic RP-do not differ significantly for the results of postoperative erectile dysfunction (ED) and continence, the fear of losing erectile function (EF) is often an important factor for preoperatively sexually active men when deciding for or against a procedure. To review the available literature on rehabilitation of EF after RP and to evaluate the value of the "Kiel concept" against different strategies of phosphodiesterase type 5 inhibitor (PDE5i) low-dose treatments. A review of the available literature up to January 2017 was undertaken using the key terms postsurgical ED, penile rehabilitation," PDE5i rehabilitation, and PDE5i daily dose treatment. As a main outcome measure we chose reviewed different concepts on the rehabilitation of EF after RP, taking into account the clinical background of the Kiel concept. The different therapeutic concepts for rehabilitation of EF after nerve-sparing RP are surprising. The most frequently applied method is application of different PDE5is. Despite different studies on efficacy, the issue of an optimal concept remains unresolved. The reason for this, among others, can be found in the difficulty of comparing different studies, which can vary with respect to the degree of nerve sparing, postoperative preservation of nocturnal erections, concomitant morbidity, and the number and experience of surgeons. In 86% of patients, the Kiel concept has been shown to support rehabilitation of EF after nerve-sparing RP with some form of therapeutic method. The Kiel concept is one therapeutic option among other comparable therapeutic options. Osmonov DK, Jünemann KP, Bannowsky A. The "Kiel Concept" of Long-Term Administration of Daily Low-Dose Sildenafil Initiated in the Immediate Post-Prostatectomy Period: Evaluation and Comparison With the International Literature on Penile Rehabilitation. Sex Med Rev 2017;5:387-392. Copyright © 2017 International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.

Orbital service module systems analysis study documentation. Volume 2: Technical report

NASA Technical Reports Server (NTRS)

1978-01-01

Near term, cost effective concepts were defined to augment the power and duration capability offered to shuttle payload users. Feasible concept options that could evolve to provide free-flying power and other services to users in the 1984 time frame were also examined.

13 CFR 124.514 - Exercise of 8(a) options and modifications.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Exercise of 8(a) options and... Contractual Assistance § 124.514 Exercise of 8(a) options and modifications. (a) Unpriced options. The exercise of an unpriced option is considered to be a new contracting action. (1) If a concern has graduated...

13 CFR 124.514 - Exercise of 8(a) options and modifications.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Exercise of 8(a) options and... Contractual Assistance § 124.514 Exercise of 8(a) options and modifications. (a) Unpriced options. The exercise of an unpriced option is considered to be a new contracting action. (1) If a concern has graduated...

13 CFR 124.514 - Exercise of 8(a) options and modifications.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Exercise of 8(a) options and... Contractual Assistance § 124.514 Exercise of 8(a) options and modifications. (a) Unpriced options. The exercise of an unpriced option is considered to be a new contracting action. (1) If a concern has graduated...

13 CFR 124.514 - Exercise of 8(a) options and modifications.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Exercise of 8(a) options and... Contractual Assistance § 124.514 Exercise of 8(a) options and modifications. (a) Unpriced options. The exercise of an unpriced option is considered to be a new contracting action. (1) If a concern has graduated...

13 CFR 124.514 - Exercise of 8(a) options and modifications.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Exercise of 8(a) options and... Contractual Assistance § 124.514 Exercise of 8(a) options and modifications. (a) Unpriced options. The exercise of an unpriced option is considered to be a new contracting action. (1) If a concern has graduated...

[The Probabilistic Efficiency Frontier: A Value Assessment of Treatment Options in Hepatitis C].

PubMed

Mühlbacher, Axel C; Sadler, Andrew

2017-06-19

Background The German Institute for Quality and Efficiency in Health Care (IQWiG) recommends the concept of the efficiency frontier to assess health care interventions. The efficiency frontier supports regulatory decisions on reimbursement prices for the appropriate allocation of health care resources. Until today this cost-benefit assessment framework has only been applied on the basis of individual patient-relevant endpoints. This contradicts the reality of a multi-dimensional patient benefit. Objective The objective of this study was to illustrate the operationalization of multi-dimensional benefit considering the uncertainty in clinical effects and preference data in order to calculate the efficiency of different treatment options for hepatitis C (HCV). This case study shows how methodological challenges could be overcome in order to use the efficiency frontier for economic analysis and health care decision-making. Method The operationalization of patient benefit was carried out on several patient-relevant endpoints. Preference data from a discrete choice experiment (DCE) study and clinical data based on clinical trials, which reflected the patient and the clinical perspective, respectively, were used for the aggregation of an overall benefit score. A probabilistic efficiency frontier was constructed in a Monte Carlo simulation with 10000 random draws. Patient-relevant endpoints were modeled with a beta distribution and preference data with a normal distribution. The assessment of overall benefit and costs provided information about the adequacy of the treatment prices. The parameter uncertainty was illustrated by the price-acceptability-curve and the net monetary benefit. Results Based on the clinical and preference data in Germany, the interferon-free treatment options proved to be efficient for the current price level. The interferon-free therapies of the latest generation achieved a positive net cost-benefit. Within the decision model, these therapies showed a maximum overall benefit. Due to their high additional benefit and approved prices, the therapies lie above of the extrapolated efficiency frontier, which suggests that these options have efficient reimbursement prices. Considering uncertainty, even a higher price would have resulted in a positive cost-benefit ratio. Conclusion IQWiG's efficiency frontier was used to assess the value of different treatment options in HCV. This study demonstrates that the probabilistic efficiency frontier, price-acceptability-curve and the net monetary benefit can contribute essential information to reimbursement decisions and price negotiations. © Georg Thieme Verlag KG Stuttgart · New York.

Educational Choice in Secondary School in Flanders: The Relative Impact of Occupational Interests on Option Choice

ERIC Educational Resources Information Center

Pinxten, Maarten; De Fraine, Bieke; Van Den Noortgate, Wim; Van Damme, Jan; Anumendem, Dickson

2012-01-01

The present study aims at unravelling the myriad of student-level (i.e., gender, socioeconomic status [SES], academic self-concept, achievement, ability, and occupational interests) and school-level (i.e., gender composition, maths composition, and SES composition) determinants of option choice in the academic track of secondary school in…

The Conquest of Outer Space--Optional Curriculum Model

ERIC Educational Resources Information Center

Florian, Gabriel; Florian, Aurelia-Daniela; Pufu, Nicolae

2015-01-01

This paper proposes an optional syllabus for the students in the XIIth grade. The proposed theme analyzes the concept of "variable mass" both in terms of classical mechanics and relativistic mechanics. In terms of classical mechanics we refer to the slow motion of a body, whose mass ranges in ascending way (by annealing a mass particle…

78 FR 14597 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-06

... assessed different fees than other indexes.\\21\\ In addition, the concept of offering a volume discount to.... This volume discount on trading Options on Treasury Securities will serve to increase order flow, which... options transaction charge. It is also reasonable and equitable to offer a floor volume discount on...

Space transfer concepts and analyses for exploration missions: Technical directive 10

NASA Technical Reports Server (NTRS)

Woodcock, Gordon R.

1992-01-01

The current technical effort is part of the third phase of a broad-scoped and systematic study of space transfer concepts for human lunar and Mars missions. The study addressed issues that were raised during the previous phases but specifically on launch vehicle size trades and MEV options.

The Impact of the Vocational Assessment Process on Juvenile Offender Self Concept

ERIC Educational Resources Information Center

McAuley-Davis, Talisha

2013-01-01

Juvenile crime and recidivism continue to be significant, costly issues in American society. Employment contributes to successful reentry and lower recidivism. However, low self concept and problems with exploring careers and identifying options may interfere with juvenile offenders' abilities to plan for employment and successfully carry out…

Cultural Conceptions of Morality: Examining Laypeople's Associations of Moral Character

ERIC Educational Resources Information Center

Vauclair, Christin-Melanie; Wilson, Marc; Fischer, Ronald

2014-01-01

Whether moral conceptions are universal or culture-specific is controversial in moral psychology. One option is to refrain from imposing theoretical constraints and to ask laypeople from different cultures how "they" conceptualize morality. Our article adopts this approach by examining laypeople's associations of moral character in…

Space station needs, attributes and architectural options. Volume 1, attachment 1: Executive summary NASA

NASA Technical Reports Server (NTRS)

1983-01-01

User alignment plan, physical and life sciences and applications, commercial requirements national security, space operations, user needs, foreign contacts, mission scenario analysis and architectural concepts, alternative systems concepts, mission operations architectural development, architectural analysis trades, evolution, configuration, and technology development are discussed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klimsiak, Tomasz, E-mail: tomas@mat.umk.pl; Rozkosz, Andrzej, E-mail: rozkosz@mat.umk.pl

In the paper we consider the problem of valuation of American options written on dividend-paying assets whose price dynamics follow the classical multidimensional Black and Scholes model. We provide a general early exercise premium representation formula for options with payoff functions which are convex or satisfy mild regularity assumptions. Examples include index options, spread options, call on max options, put on min options, multiply strike options and power-product options. In the proof of the formula we exploit close connections between the optimal stopping problems associated with valuation of American options, obstacle problems and reflected backward stochastic differential equations.

A discontinuous Galerkin method for numerical pricing of European options under Heston stochastic volatility

NASA Astrophysics Data System (ADS)

Hozman, J.; Tichý, T.

2016-12-01

The paper is based on the results from our recent research on multidimensional option pricing problems. We focus on European option valuation when the price movement of the underlying asset is driven by a stochastic volatility following a square root process proposed by Heston. The stochastic approach incorporates a new additional spatial variable into this model and makes it very robust, i.e. it provides a framework to price a variety of options that is closer to reality. The main topic is to present the numerical scheme arising from the concept of discontinuous Galerkin methods and applicable to the Heston option pricing model. The numerical results are presented on artificial benchmarks as well as on reference market data.

Recent concepts in missions to Mars - Extraterrestrial processes

NASA Technical Reports Server (NTRS)

Ramohalli, K. N.; Ash, R. L.; Lawton, E. A.; French, J. R.; Frisbee, R. H.

1986-01-01

This paper presents some recent concepts in Mars Sample Return (MSR) missions that utilize extraterrestrial resources. The concepts examined include the power and energy needs of this mission. It is shown that solar energy is not especially attractive. Radioisotopic power generator and a Rankine cycle use are seen to be viable options. Quantitative estimates, taking into consideration state-of-the-art and projected technologies indicate that the power/energy per se is not critical to the mission - but reliability is. Hence, various modern options for the components of the power generation and utilization are discussed. The dramatic savings in Shuttle (or other) vehicle launches are quantitatively plotted. The basic system that is discussed here is the production of hydrocarbon (methane) fuel and oxygen from Martian atmosphere. For the simplest mission, it is seen that earth-carried methane burned with oxygen produced on site provides the best system.

Meta Search Engines.

ERIC Educational Resources Information Center

Garman, Nancy

1999-01-01

Describes common options and features to consider in evaluating which meta search engine will best meet a searcher's needs. Discusses number and names of engines searched; other sources and specialty engines; search queries; other search options; and results options. (AEF)

Status of Progress Made Toward Preliminary Design Concepts for the Inventory in Select Media for DOE-Managed HLW/SNF

DOE Office of Scientific and Technical Information (OSTI.GOV)

Matteo, Edward N.; Hardin, Ernest L.; Hadgu, Teklu

As the title suggests, this report provides a summary of the status and progress for the Preliminary Design Concepts Work Package. Described herein are design concepts and thermal analysis for crystalline and salt host media. The report concludes that thermal management of defense waste, including the relatively small subset of high thermal output waste packages, is readily achievable. Another important conclusion pertains to engineering feasibility, and design concepts presented herein are based upon established and existing elements and/or designs. The multipack configuration options for the crystalline host media pose the greatest engineering challenges, as these designs involve large, heavy wastemore » packages that pose specific challenges with respect to handling and emplacement. Defense-related Spent Nuclear Fuel (DSNF) presents issues for post-closure criticality control, and a key recommendation made herein relates to the need for special packaging design that includes neutron-absorbing material for the DSNF. Lastly, this report finds that the preliminary design options discussed are tenable for operational and post-closure safety, owing to the fact that these concepts have been derived from other published and well-studied repository designs.« less

Design of the helium cooled lithium lead breeding blanket in CEA: from TBM to DEMO

NASA Astrophysics Data System (ADS)

Aiello, G.; Aubert, J.; Forest, L.; Jaboulay, J.-C.; Li Puma, A.; Boccaccini, L. V.

2017-04-01

The helium cooled lithium lead (HCLL) blanket concept was originally developed in CEA at the beginning of 2000: it is one of the two European blanket concepts to be tested in ITER in the form of a test blanket module (TBM) and one of the four blanket concepts currently being considered for the DEMOnstration reactor that will follow ITER. The TBM is a highly optimized component for the ITER environment that will provide crucial information for the development of the DEMO blanket, but its design needs to be adapted to the DEMO reactor. With respect to the TBM design, reduction of the steel content in the breeding zone (BZ) is sought in order to maximize tritium breeding reactions. Different options are being studied, with the potential of reaching tritium breeding ratio (TBR) values up to 1.21. At the same time, the design of the back supporting structure (BSS), which is a DEMO specific component that has to support the blanket modules inside the vacuum vessel (VV), is ongoing with the aim of maximizing the shielding power and minimizing pumping power. This implies a re-engineering of the modules’ attachment system. Design changes however, will have an impact on the manufacturing and assembly sequences that are being developed for the HCLL-TBM. Due to the differences in joint configurations, thicknesses to be welded, heat dissipation and the various technical constraints related to the accessibility of the welding tools and implementation of non-destructive examination (NDE), the manufacturing procedure should be adapted and optimized for DEMO design. Laser welding instead of TIG could be an option to reduce distortions. The time-of-flight diffraction (TOFD) technique is being investigated for NDE. Finally, essential information expected from the HCLL-TBM program that will be needed to finalize the DEMO design is discussed.

Evaluation of a Decision Aid for Women with Epilepsy Who Are Considering Pregnancy: A Randomized Controlled Trial.

PubMed

McGrath, Amanda; Sharpe, Louise; Lah, Suncica; Parratt, Kaitlyn

2017-07-01

For many women with epilepsy (WWE), decision making about pregnancy is complicated by considerations such as the potential teratogenicity of antiepileptic drugs, offspring risk of epilepsy, seizure occurrence during pregnancy, and the challenges of parenting amidst poorly controlled seizures. This proof-of-concept, randomized controlled trial aimed to evaluate a decision aid (DA) developed to help WWE decide if they should start or enlarge their families. Seventy-nine WWE of childbearing age were recruited from Epilepsy Action Australia between October and November 2013 and randomized to receive the intervention (the DA) or not, and to complete a set of questionnaires pre- and post- intervention. The DA, delivered as a PDF booklet, provided balanced evidence-based information about options, risks and benefits, including probabilities; as well as steps for clarifying values and considering options within one's personal situation. Compared with the control group, the DA group had statistically significant improvements in knowledge about pregnancy and epilepsy (Cohen's d = 1.24; 95%CI = 0.77 to 1.83) and reduced decisional conflict (Cohen's d = 0.59; 95%CI = 0.21 to 0.99). Changes in decision self-efficacy, certainty of choice, patient-practitioner communication abilities and value congruence with choice were comparable between the DA and control group. Importantly, women's decisions about motherhood were not biased towards either direction, and there were no adverse effects on depression or anxiety. All women who received the DA indicated they would recommend it to other WWE. The DA has the potential to serve as a useful support tool for WWE who are considering motherhood. Future research is needed to test the DA in clinical settings with guidance from a health professional. The trial was registered with the Australian New Zealand Clinical Trials Registry (ID ACTRN12613001082796).

Preliminary Assessment of Using Gelled and Hybrid Propellant Propulsion for VTOL/SSTO Launch Systems

NASA Technical Reports Server (NTRS)

Palaszewski, Bryan; OLeary, Robert; Pelaccio, Dennis G.

1998-01-01

A novel, reusable, Vertical-Takeoff-and-Vertical-Takeoff-and-Landing, Single-Stage-to-Orbit (VTOL/SSTO) launch system concept, named AUGMENT-SSTO, is presented in this paper to help quantify the advantages of employing gelled and hybrid propellant propulsion system options for such applications. The launch vehicle system concept considered uses a highly coupled, main high performance liquid oxygen/liquid hydrogen (LO2/LH2) propulsion system, that is used only for launch, while a gelled or hybrid propellant propulsion system auxiliary propulsion system is used during final orbit insertion, major orbit maneuvering, and landing propulsive burn phases of flight. Using a gelled or hybrid propellant propulsion system for major orbit maneuver burns and landing has many advantages over conventional VTOL/SSTO concepts that use LO2/LH2 propulsion system(s) burns for all phases of flight. The applicability of three gelled propellant systems, O2/H2/Al, O2/RP-1/Al, and NTO/MMH/Al, and a state-of-the-art (SOA) hybrid propulsion system are examined in this study. Additionally, this paper addresses the applicability of a high performance gelled O2/H2 propulsion system to perform the primary, as well as the auxiliary propulsion system functions of the vehicle.

Advanced Technology Composite Fuselage - Repair and Damage Assessment Supporting Maintenance

NASA Technical Reports Server (NTRS)

Flynn, B. W.; Bodine, J. B.; Dopker, B.; Finn, S. R.; Griess, K. H.; Hanson, C. T.; Harris, C. G.; Nelson, K. M.; Walker, T. H.; Kennedy, T. C.;

Techno-environmental assessment of the green biorefinery concept: Combining process simulation and life cycle assessment at an early design stage.

PubMed

Corona, Andrea; Ambye-Jensen, Morten; Vega, Giovanna Croxatto; Hauschild, Michael Zwicky; Birkved, Morten

2018-09-01

The Green biorefinery (GBR) is a biorefinery concept that converts fresh biomass into value-added products. The present study combines a Process Flowsheet Simulation (PFS) and Life Cycle Assessment (LCA) to evaluate the technical and environmental performance of different GBR configurations and the cascading utilization of the GBR output. The GBR configurations considered in this study, test alternatives in the three main steps of green-biorefining: fractionation, precipitation, and protein separation. The different cascade utilization alternatives analyse different options for press-pulp utilization, and the LCA results show that the environmental profile of the GBR is highly affected by the utilization of the press-pulp and thus by the choice of conventional product replaced by the press-pulp. Furthermore, scenario analysis of different GBR configurations shows that higher benefits can be achieved by increasing product yields rather than lowering energy consumption. Green biorefining is shown to be an interesting biorefining concept, especially in a Danish context. Biorefining of green biomass is technically feasible and can bring environmental savings, when compared to conventional production methods. However, the savings will be determined by the processing involved in each conversion stage and on the cascade utilization of the different platform products. Copyright © 2018 Elsevier B.V. All rights reserved.

Concept for a Lunar Transfer Vehicle for Small Satellite Delivery to the Moon from the International Space Station

NASA Technical Reports Server (NTRS)

Elliott, John; Alkalai, Leon

2010-01-01

The International Space Station (ISS) has developed as a very capable center for scientific research in Lower Earth Orbit. An additional potential of the ISS that has not thus far been exploited, is the use of this orbiting plat-form for the assembly and launching of vehicles that could be sent to more distant destinations. This paper reports the results of a recent study that looked at an architecture and conceptual flight system design for a lunar transfer vehicle (LTV) that could be delivered to the ISS in segments, assembled, loaded with payload and launched from the ISS with the objective of delivering multiple small and micro satellites to lunar orbit. The design of the LTV was optimized for low cost and high payload capability, as well as ease of assembly. The resulting design would use solar electric propulsion (SEP) to carry a total payload mass of 250 kg from the ISS to a 100 km lunar orbit. A preliminary concept of operations was developed considering currently available delivery options and ISS capabili-ties that should prove flexible enough to accommodate a variety of payloads and missions. This paper will present an overview of the study, including key trades, mission and flight system design, and notional operational concept.

Overview and Current Status of Analyses of Potential LEU Design Concepts for TREAT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Connaway, H. M.; Kontogeorgakos, D. C.; Papadias, D. D.

2015-10-01

Neutronic and thermal-hydraulic analyses have been performed to evaluate the performance of different low-enriched uranium (LEU) fuel design concepts for the conversion of the Transient Reactor Test Facility (TREAT) from its current high-enriched uranium (HEU) fuel. TREAT is an experimental reactor developed to generate high neutron flux transients for the testing of nuclear fuels. The goal of this work was to identify an LEU design which can maintain the performance of the existing HEU core while continuing to operate safely. A wide variety of design options were considered, with a focus on minimizing peak fuel temperatures and optimizing the powermore » coupling between the TREAT core and test samples. Designs were also evaluated to ensure that they provide sufficient reactivity and shutdown margin for each control rod bank. Analyses were performed using the core loading and experiment configuration of historic M8 Power Calibration experiments (M8CAL). The Monte Carlo code MCNP was utilized for steady-state analyses, and transient calculations were performed with the point kinetics code TREKIN. Thermal analyses were performed with the COMSOL multi-physics code. Using the results of this study, a new LEU Baseline design concept is being established, which will be evaluated in detail in a future report.« less

Consider Creating a Channel Management Strategy with Both Colleagues and Patients

PubMed Central

Felkey, Bill G.; Fox, Brent I.

2013-01-01

Patient engagement is poised to provide considerable opportunities for reaching patients. The range of connectivity options should be considered to include the best option for each specific patient. In this article, we address this area of growing importance, telecommunication channel management. PMID:24421455

Trade Study of Multiple Thruster Options for the Mars Airplane Concept

NASA Technical Reports Server (NTRS)

Kuhl, Christopher A.; Gayle, Steven W.; Hunter, Craig A.; Kenney, Patrick S.; Scola, Salvatore; Paddock, David A.; Wright, Henry S.; Gasbarre, Joseph F.

2009-01-01

A trade study was performed at NASA Langley Research Center under the Planetary Airplane Risk Reduction (PARR) project (2004-2005) to examine the option of using multiple, smaller thrusters in place of a single large thruster on the Mars airplane concept with the goal to reduce overall cost, schedule, and technical risk. The 5-lbf (22N) thruster is a common reaction control thruster on many satellites. Thousands of these types of thrusters have been built and flown on numerous programs, including MILSTAR and Intelsat VI. This study has examined the use of three 22N thrusters for the Mars airplane propulsion system and compared the results to those of the baseline single thruster system.

The New Explorers teacher`s guide: The new language of science

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-09-01

The Chicago Science Explorers Program is designed to make students aware of the many career options that are available to them which involve science. The program also hopes to encourage students to consider a career in science by providing interesting classroom experiences, information on various careers generated from the video tape, and a class field trip. In the videotape The New Language of Science, Dr. Larry Smarr of the University of Illinois illustrates how supercomputers can create visualizations of such complex scientific concepts and events as black holes in space, microbursts, smog, drug interactions in the body, earthquakes, and tornadoes.more » It also illustrates how math and science are integrated and emphasizes the need for students to take as much advanced mathematics as is offered at the junior high and high school level. Another underlying concept of the videotape is teamwork. Often students think of science as being an isolated career and this video tape clearly demonstrates that no one scientist would have enough knowledge to create a visualization alone. This report is the teacher`s guide for this video.« less

Concept of operations for knowledge discovery from Big Data across enterprise data warehouses

NASA Astrophysics Data System (ADS)

Sukumar, Sreenivas R.; Olama, Mohammed M.; McNair, Allen W.; Nutaro, James J.

2013-05-01

The success of data-driven business in government, science, and private industry is driving the need for seamless integration of intra and inter-enterprise data sources to extract knowledge nuggets in the form of correlations, trends, patterns and behaviors previously not discovered due to physical and logical separation of datasets. Today, as volume, velocity, variety and complexity of enterprise data keeps increasing, the next generation analysts are facing several challenges in the knowledge extraction process. Towards addressing these challenges, data-driven organizations that rely on the success of their analysts have to make investment decisions for sustainable data/information systems and knowledge discovery. Options that organizations are considering are newer storage/analysis architectures, better analysis machines, redesigned analysis algorithms, collaborative knowledge management tools, and query builders amongst many others. In this paper, we present a concept of operations for enabling knowledge discovery that data-driven organizations can leverage towards making their investment decisions. We base our recommendations on the experience gained from integrating multi-agency enterprise data warehouses at the Oak Ridge National Laboratory to design the foundation of future knowledge nurturing data-system architectures.

[The organo-clinical hiatus today. Some thoughts about Neurosciences, Psychopathology and Clinical Psychiatry in the early twenty-first century].

PubMed

Motuca, Mariano

2016-01-01

The concept of "organo clinical-hiatus" prepared by Henri Ey the mid-twentieth century has transcended the boundaries of time and has an amazing utility if it is considered from the point of view of both epistemological and clinical. Current developments in the field of neuroscience on the one hand and effective in clinical practice of psychopathological concepts born in the nineteenth century on the other, pose a challenge for psychiatrists today. It is important not to take a naive position on the new neuroscientific knowledge adopting a dogmatic stance that keeps us patient and while maintaining a clear position that avoids specialty contempt by those who argue that mental illness is a mere construct sustained by the medical hegemonic power. We believe the best way to protect our psychiatric practice of involuntary biases and attacks blinded by reductionist ideas is having a historical knowledge of our discipline and a solid epistemological basis. That way we will have the largest options to help our patients.

Managing forest structure and fire hazard--a tool for planners.

Treesearch

M.C. Johnson; D.L. Peterson; C.L. Raymond

2006-01-01

Fire planners and other resource managers need to examine a range of potential fuel and vegetation treatments to select options that will lead to desired outcomes for fire hazard and natural resource conditions. A new approach to this issue integrates concepts and tools from silviculture and fuel science to quantify outcomes for a large number of treatment options in...

Space station systems analysis study. Part 2, Volume 2. [technical report

NASA Technical Reports Server (NTRS)

1977-01-01

Specific system options are defined and identified for a cost effective space station capable of orderly growth with regard to both function and orbit location. Selected program options are analyzed and configuration concepts are developed to meet objectives for the satellite power system, earth servicing, space processing, and supporting activities. Transportation systems are analyzed for both LEO and GEO orbits.

"An Option for Art But Not an Option for Life": Beauty as an Educational Imperative

ERIC Educational Resources Information Center

Winston, Joe

2008-01-01

This article proposes that beauty deserves to become an area of key interest to educationalists. The article begins by examining the reasons for the neglect of beauty in educational discourse before proposing how it might regain its influence as an educational concept by re-addressing the Platonic tradition and, in particular, by finding its…

Preliminary Concept of Operations for the Spent Fuel Management System--WM2017

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cumberland, Riley M; Adeniyi, Abiodun Idowu; Howard, Rob L

The Nuclear Fuels Storage and Transportation Planning Project (NFST) within the U.S. Department of Energy s Office of Nuclear Energy is tasked with identifying, planning, and conducting activities to lay the groundwork for developing interim storage and transportation capabilities in support of an integrated waste management system. The system will provide interim storage for commercial spent nuclear fuel (SNF) from reactor sites and deliver it to a repository. The system will also include multiple subsystems, potentially including; one or more interim storage facilities (ISF); one or more repositories; facilities to package and/or repackage SNF; and transportation systems. The project teammore » is analyzing options for an integrated waste management system. To support analysis, the project team has developed a Concept of Operations document that describes both the potential integrated system and inter-dependencies between system components. The goal of this work is to aid systems analysts in the development of consistent models across the project, which involves multiple investigators. The Concept of Operations document will be updated periodically as new developments emerge. At a high level, SNF is expected to travel from reactors to a repository. SNF is first unloaded from reactors and placed in spent fuel pools for wet storage at utility sites. After the SNF has cooled enough to satisfy loading limits, it is placed in a container at reactor sites for storage and/or transportation. After transportation requirements are met, the SNF is transported to an ISF to store the SNF until a repository is developed or directly to a repository if available. While the high level operation of the system is straightforward, analysts must evaluate numerous alternative options. Alternative options include the number of ISFs (if any), ISF design, the stage at which SNF repackaging occurs (if any), repackaging technology, the types of containers used, repository design, component sizing, and timing of events. These alternative options arise due to technological, economic, or policy considerations. As new developments regularly emerge, the operational concepts will be periodically updated. This paper gives an overview of the different potential alternatives identified in the Concept of Operations document at a conceptual level.« less

Assessment of the Technical Maturity of Generation IV Concepts for Test or Demonstration Reactor Applications, Revision 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gougar, Hans David

2015-10-01

The United States Department of Energy (DOE) commissioned a study the suitability of different advanced reactor concepts to support materials irradiations (i.e. a test reactor) or to demonstrate an advanced power plant/fuel cycle concept (demonstration reactor). As part of the study, an assessment of the technical maturity of the individual concepts was undertaken to see which, if any, can support near-term deployment. A Working Group composed of the authors of this document performed the maturity assessment using the Technical Readiness Levels as defined in DOE’s Technology Readiness Guide . One representative design was selected for assessment from of each ofmore » the six Generation-IV reactor types: gas-cooled fast reactor (GFR), lead-cooled fast reactor (LFR), molten salt reactor (MSR), supercritical water-cooled reactor (SCWR), sodium-cooled fast reactor (SFR), and very high temperature reactor (VHTR). Background information was obtained from previous detailed evaluations such as the Generation-IV Roadmap but other technical references were also used including consultations with concept proponents and subject matter experts. Outside of Generation IV activity in which the US is a party, non-U.S. experience or data sources were generally not factored into the evaluations as one cannot assume that this data is easily available or of sufficient quality to be used for licensing a US facility. The Working Group established the scope of the assessment (which systems and subsystems needed to be considered), adapted a specific technology readiness scale, and scored each system through discussions designed to achieve internal consistency across concepts. In general, the Working Group sought to determine which of the reactor options have sufficient maturity to serve either the test or demonstration reactor missions.« less

Space Operations Center system analysis study extension. Volume 2: Programmatics and cost

NASA Technical Reports Server (NTRS)

1982-01-01

A summary of Space Operations Center (SOC) orbital space station costs, program options and program recommendations is presented. Program structure, hardware commonality, schedules and program phasing are considered. Program options are analyzed with respect to mission needs, design and technology options, and anticipated funding constraints. Design and system options are discussed.

Space transfer concepts and analyses for exploration missions, phase 4

NASA Technical Reports Server (NTRS)

Woodcock, Gordon R.

1993-01-01

Earlier studies carried out under this contract covered a wide range of lunar and Mars transportation options, and lunar rove concepts and technology needs. The current report discusses the activities conducted under Technical Directives 16 and 17. Mars transportation was addressed as well as a review and update of architectures and propulsion systems.

Australian Biology Test Item Bank, Years 11 and 12. Volume II: Year 12.

ERIC Educational Resources Information Center

Brown, David W., Ed.; Sewell, Jeffrey J., Ed.

This document consists of test items which are applicable to biology courses throughout Australia (irrespective of course materials used); assess key concepts within course statement (for both core and optional studies); assess a wide range of cognitive processes; and are relevant to current biological concepts. These items are arranged under…

The Collegiate Student Orientation Scale (CSOS): Application of the Marketing Concept to Higher Education

ERIC Educational Resources Information Center

Bristow, Dennis N.; Schneider, Kenneth C.

2002-01-01

Today's administrators in higher education face a dynamic marketplace that offers students an array of educational options and alternatives. Much like organizations more traditionally associated with marketing strategies and tactics, colleges and universities are gradually moving towards and embracing the marketing concept and a focus on consumer…

Australian Biology Test Item Bank, Years 11 and 12. Volume I: Year 11.

ERIC Educational Resources Information Center

Brown, David W., Ed.; Sewell, Jeffrey J., Ed.

This document consists of test items which are applicable to biology courses throughout Australia (irrespective of course materials used); assess key concepts within course statement (for both core and optional studies); assess a wide range of cognitive processes; and are relevant to current biological concepts. These items are arranged under…

Finding a Plausible Option for Revitalising Agricultural Higher Education in India: A Systematic Review

ERIC Educational Resources Information Center

Kumar, Niraj

2016-01-01

The objectives of this paper were to explore the existing status of agricultural higher education in India, application of marketing concepts in similar institutions and to find the most appropriate marketing concept to make agricultural higher education more competitive. Extensive searches of relevant agricultural education, business management…

Materials experiment carrier concepts definition study. Volume 2: Technical report, part 2

NASA Technical Reports Server (NTRS)

1981-01-01

A materials experiment carrier (MEC) that provides effective accommodation of the given baseline materials processing in space (MPS) payloads and demonstration of the MPS platform concept for high priority materials processing science, multidiscipline MPS investigations, host carrier for commercial MPS payloads, and system economy of orbital operations is defined. The study flow of task work is shown. Study tasks featured analysis and trades to identify the MEC system concept options.

A novel conceptual framework for understanding the mechanism of adherence to long term therapies

PubMed Central

Reach, Gérard

2008-01-01

The World Health Organization claimed recently that improving patient adherence to long term therapies would be more beneficial than any biomedical progress. First, however, we must understand its mechanisms. In this paper I propose a novel approach using concepts elaborated in a field rarely explored in medicine, the philosophy of mind. While conventional psychological models (eg, the Health Belief Model) provide explanations and predictions which have only a statistical value, the philosophical assumption that mental states (eg, beliefs) are causally efficient (mental causation) can provide the basis for a causal theory of health behaviors. This paper shows that nonadherence to long term therapies can be described as the medical expression of a philosophical concept, that is, weakness of will. I use philosophical explanations of this concept to suggest a mechanistic explanation of nonadherence. I propose that it results from the failure of two principles of rationality. First, a principle of continence, described by the philosopher Donald Davidson in his explanation of weakness of will. This principle exhorts us to act after having considered all available arguments and according to which option we consider best. However, patients conforming to this principle of continence should rationally be nonadherent. Indeed, when patients face a choice between adherence and nonadherence, they must decide, in general, between a large, but delayed reward (eg, health) and a small, but immediate reward (eg, smoking a cigarette). According to concepts elaborated by George Ainslie and Jon Elster, the force of our desires is strongly influenced by the proximity of reward. This inter-temporal choice theory on one hand, and the mere principle of continence on the other, should therefore lead to nonadherence. Nevertheless, adherence to long term therapies is possible, as a result of the intervention of an additional principle, the principle of foresight, which tells us to give priority to mental states oriented towards the future. PMID:19920939

Comparing the ability of OPTION(12) and OPTION(5) to assess shared decision-making in genetic counselling.

PubMed

Vortel, Martina A; Adam, Shelin; Port-Thompson, Ashley V; Friedman, Jan M; Grande, Stuart W; Birch, Patricia H

2016-10-01

OPTION(12) is the most widely used tool to measure shared decision-making (SDM) in health care. A newer scale, OPTION(5), has been proposed as a more parsimonious measure that better addresses core concepts of SDM. This study compares OPTION(5) to OPTION(12) in prenatal genetic counselling. Two raters independently used OPTION(12) and OPTION(5) to score 27 clinical encounters between genetic counsellors (GC) and women with pregnancies at increased risk for genetic conditions. Global and item scores on the two instruments were compared to test concurrent validity and to identify usability in this context. Inter-rater reliability was also assessed for both instruments. Mean scores for OPTION(12) were 43.8 (SD=9.7), and for OPTION(5) were=60.6 (SD=12.5). The correlation between OPTION(12) and OPTION(5) scores was r=0.70. Inter-rater reliability was 0.70 and 0.85 for OPTION(12) and OPTION(5) respectively, however mean inter-rater reliability for individual items was 0.31 and 0.63 for OPTION(12) and OPTION(5) respectively. GCs exhibit SDM as measured by both OPTION instruments. OPTION(5) exhibits improved psychometric performance relative to OPTION(12), and more specifically targets the core constructs of SDM. However, refinement of OPTION instruments or manuals is needed to improve reliability and validity in GC assessment. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Direct disposal of spent fuel: developing solutions tailored to Japan

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kawamura, Hideki; McKinley, Ian G

2013-07-01

With the past Government policy of 100% reprocessing in Japan now open to discussion, options for direct disposal of spent fuel (SF) are now being considered in Japan. The need to move rapidly ahead in developing spent fuel management concepts is closely related to the ongoing debate on the future of nuclear power in Japan and the desire to understand the true costs of the entire life cycle of different options. Different scenarios for future nuclear power - and associated decisions on extent of reprocessing - will give rise to quite different inventories of SF with different disposal challenges. Althoughmore » much work has been carried out spent fuel disposal within other national programmes, the potential for mining the international knowledge base is limited by the boundary conditions for disposal in Japan. Indeed, with a volunteer approach to siting, no major salt deposits and few undisturbed sediments, high tectonic activity, relatively corrosive groundwater and no deserts, it is evident that a tailored solution is needed. Nevertheless, valuable lessons can be learned from projects carried out worldwide, if focus is placed on basic principles rather than implementation details. (authors)« less

Emerging concepts in alcoholic hepatitis

PubMed Central

Fung, Phoenix; Pyrsopoulos, Nikolaos

2017-01-01

Severe alcoholic hepatitis is implicated as a costly, worldwide public health issue with high morbidity and mortality. The one-month survival for severe alcoholic hepatitis is low with mortality rates high as 30%-50%. Abstinence from alcohol is the recommended first-line treatment. Although corticosteroids remain as the current evidence based option for selected patients with discriminant function > 32, improvement of short-term survival rate may be the only benefit. Identification of individuals with risk factors for the development of severe alcoholic hepatitis may provide insight to the diverse clinical spectrum and prognosis of the disease. The understanding of the complex pathophysiologic processes of alcoholic hepatitis is the key to elucidating new therapeutic treatments. Newer research describes the use of gut microbiota modification, immune modulation, stimulation of liver regeneration, caspase inhibitors, farnesoid X receptors, and the extracorporeal liver assist device to aid in hepatocellular recovery. Liver transplantation can be considered as the last medical option for patients failing conventional medical interventions. Although the preliminary data is promising in patients with low risk of recividism, controversy remains due to organ scarcity. This review article comprehensively summarizes the epidemiology, pathophysiology, risk factors, and prognostic indicators of severe alcoholic hepatitis with a focus on the current and emerging therapeutics. PMID:28515843

A decision support tool for sustainable planning of urban water systems: presenting the Dynamic Urban Water Simulation Model.

PubMed

Willuweit, Lars; O'Sullivan, John J

2013-12-15

Population growth, urbanisation and climate change represent significant pressures on urban water resources, requiring water managers to consider a wider array of management options that account for economic, social and environmental factors. The Dynamic Urban Water Simulation Model (DUWSiM) developed in this study links urban water balance concepts with the land use dynamics model MOLAND and the climate model LARS-WG, providing a platform for long term planning of urban water supply and water demand by analysing the effects of urbanisation scenarios and climatic changes on the urban water cycle. Based on potential urbanisation scenarios and their effects on a city's water cycle, DUWSiM provides the functionality for assessing the feasibility of centralised and decentralised water supply and water demand management options based on forecasted water demand, stormwater and wastewater generation, whole life cost and energy and potential for water recycling. DUWSiM has been tested using data from Dublin, the capital of Ireland, and it has been shown that the model is able to satisfactorily predict water demand and stormwater runoff. Copyright © 2013 Elsevier Ltd. All rights reserved.

Platelet-rich plasma for bone healing and regeneration.

PubMed

Oryan, Ahmad; Alidadi, Soodeh; Moshiri, Ali

2016-01-01

Successful healing of large bone defects (LBDs) is a complicated phenomenon because the body's natural ability often fails to effectively repair the LBDs. New modalities should be utilized to increase the quality and accelerate bone healing. Platelet concentrates in different forms can be considered an attractive option for such purpose. Platelets as a natural source of growth factors, cytokines, and other micro and macromolecules are hypothesized to improve bone healing. This review has covered important concepts regarding platelet-rich plasma (PRP) including mechanisms of action, preparation protocols and their differences, and factors affecting the PRP efficacy during bone healing. In addition, the most recent studies in different levels which evaluated the role of PRP on bone repair has been reviewed and discussed to clarify the controversies and conflicts, and to illustrate a future prospective and directions for orthopedic surgeons to overcome current limitations and difficulties. As the efficacy of PRP is dependent on various factors, the outcome of PRP therapy is variable and unpredictable in orthopedic patients. Therefore, it is still too soon to suggest PRP as the first line treatment option in complicated bone injuries such as LBDs and nonunions. However, combination of PRP with natural and synthetic biomaterials can enhance the effectiveness of PRP.

Spatially organized «vertical city» as a synthesis of tall buildings and airships

NASA Astrophysics Data System (ADS)

Gagulina, Olga; Matovnikov, Sergei

2018-03-01

The paper explores the compact city concept based on the «spatial» urban development principles and describes the prerequisites and possible methods to move from «horizontal» planning to «vertical» urban environments. It highlights the close connection between urban space, high-rise city landscape and conveyance options and sets out the ideas for upgrading the existing architectural and urban planning principles. It also conceptualizes the use of airships to create additional spatial connections between urban structure elements and high-rise buildings. Functional changes are considered in creating both urban environment and internal space of tall buildings, and the environmental aspects of the new spatial model are brought to light. The paper delineates the prospects for making a truly «spatial» multidimensional city space.

[Gastrointestinal bleeding--concepts of surgical therapy in the upper gastrointestinal tract].

PubMed

Knoefel, W T; Rehders, A

2006-02-01

Bleeding of the upper gastrointestinal tract is the main symptom of a variety of possible conditions and still results in considerable mortality. Endoscopy is the first diagnostic modality, enabling rapid therapeutic intervention. In case of intractable or relapsing bleeding, surgery is often inevitable. However, emergency operations result in significantly higher mortality rates. Therefore the option of early elective surgical intervention should be considered for patients at increased risk of relapsing bleeding. If bleeding is symptomatic due to a complex underlying condition such as hemosuccus pancreaticus or hemobilia, angiography is now recognized as the definitive investigation. Angiographic hemostasis can be achieved in most cases. Due to the underlying condition, surgical management still remains the mainstay in treating these patients. This paper reviews surgical strategy in handling upper gastrointestinal bleeding.

Multi-objective decision-making under uncertainty: Fuzzy logic methods

NASA Technical Reports Server (NTRS)

Hardy, Terry L.

1995-01-01

Fuzzy logic allows for quantitative representation of vague or fuzzy objectives, and therefore is well-suited for multi-objective decision-making. This paper presents methods employing fuzzy logic concepts to assist in the decision-making process. In addition, this paper describes software developed at NASA Lewis Research Center for assisting in the decision-making process. Two diverse examples are used to illustrate the use of fuzzy logic in choosing an alternative among many options and objectives. One example is the selection of a lunar lander ascent propulsion system, and the other example is the selection of an aeration system for improving the water quality of the Cuyahoga River in Cleveland, Ohio. The fuzzy logic techniques provided here are powerful tools which complement existing approaches, and therefore should be considered in future decision-making activities.

[Data security and the handling of patient data in home monitoring systems].

PubMed

Heydenreich, F; Jürgens, C; Tost, F

2009-09-01

Data security must be considered seriously in the context of telemedical home monitoring because of the transmission and communication of patients' personal data. The contract governing medical treatment allows the ophthalmologist to process all data relevant to treatment. In Germany the legal framework for this purpose is provided by the Data Protection Act, various German hospital acts, and codes of medical professional conduct. In principle, these rules apply to telemedical home monitoring as well as to common physician-patient relationships. The patient must be informed extensively in an understandable manner and must give his or her written consent. However, the advanced options of new IT technologies demand the development of technical and organizational concepts that guarantee compliance with legal and regulatory affairs, assure data security, and prevent data abuse.

Evolving Concepts of Pulmonary Hypertension Secondary to Left Heart Disease.

PubMed

Ramu, Bhavadharini; Thenappan, Thenappan

2016-04-01

Pulmonary hypertension associated with left heart disease is the most common form of pulmonary hypertension. Although its pathophysiology remains incompletely understood, it is now well recognized that the presence of pulmonary hypertension is associated with a worse prognosis. Right ventricular failure has independent and additive prognostic value over pulmonary hypertension for adverse outcomes in left heart disease. Recently, several new terminologies have been introduced to better define and characterize the nature and severity of pulmonary hypertension. Several new treatment options including the use of pulmonary arterial hypertension specific therapies are being considered, but there is lack of evidence. Here, we review the recent advances in this field and summarize the diagnostic and therapeutic modalities of use in the management of pulmonary hypertension associated with left heart disease.

Cost-effectiveness of the management of rh-negative pregnant women.

PubMed

Duplantie, Julie; Gonzales, Odilon Martinez; Bois, Antoine; Nshimyumukiza, Léon; Gekas, Jean; Bujold, Emmanuel; Morin, Valérie; Vallée, Maud; Giguère, Yves; Gagné, Christian; Rousseau, François; Reinharz, Daniel

2013-08-01

The purpose of this study was to determine the most cost-effective option to prevent alloimmunization against the Rh factor. A virtual population of Rh-negative pregnant women in Quebec was built to simulate the cost-effectiveness of preventing alloimmunization. The model considered four options: (1) systematic use of anti-D immunoglobulin; (2) fetal Rh(D) genotyping; (3) immunological determination of the father's Rh type; (4) mixed screening: immunological determination of the father's Rh type, followed if positive by fetal Rh(D) genotyping. Two outcomes were considered, in addition to the estimated costs: (1) the number of babies without hemolytic disease, and (2) the number of surviving infants. In a first pregnancy, two options emerged as the most cost-effective options: systematic prophylaxis and immunological Rh typing of the father, with overlapping confidence intervals between them. In a second pregnancy, the results were similar. In all cases (first or second pregnancy or a combination of the two) fetal genotyping was not found to be a cost-effective option. Routine prophylaxis and immunological Rh typing of the father are the most cost-effective options for the prevention of Rh alloimmunization. Considering that immunological typing of the father would probably not be carried out by the majority of clinicians, routine prophylaxis remains the preferred option. However, this could change if the cost of Rh(D) fetal genotyping fell below $140 per sample.

Mission and Design Sensitivities for Human Mars Landers Using Hypersonic Inflatable Aerodynamic Decelerators

NASA Technical Reports Server (NTRS)

Polsgrove, Tara P.; Thomas, Herbert D.; Dwyer Ciancio, Alicia; Collins, Tim; Samareh, Jamshid

2017-01-01

Landing humans on Mars is one of NASA's long term goals. NASA's Evolvable Mars Campaign (EMC) is focused on evaluating architectural trade options to define the capabilities and elements needed to sustain human presence on the surface of Mars. The EMC study teams have considered a variety of in-space propulsion options and surface mission options. Understanding how these choices affect the performance of the lander will allow a balanced optimization of this complex system of systems problem. This paper presents the effects of mission and vehicle design options on lander mass and performance. Beginning with Earth launch, options include fairing size assumptions, co-manifesting elements with the lander, and Earth-Moon vicinity operations. Capturing into Mars orbit using either aerocapture or propulsive capture is assessed. For entry, descent, and landing both storable as well as oxygen and methane propellant combinations are considered, engine thrust level is assessed, and sensitivity to landed payload mass is presented. This paper focuses on lander designs using the Hypersonic Inflatable Aerodynamic Decelerators, one of several entry system technologies currently considered for human missions.

26 CFR 1.1563-3 - Rules for determining stock ownership.

Code of Federal Regulations, 2010 CFR

2010-04-01

... acquire such stock. For example, assume Smith owns an option to purchase 100 shares of the outstanding stock of M Corporation. Under this subparagraph, Smith is considered to own such 100 shares. The result would be the same if Smith owned an option to acquire the option (or one of a series of options) to...

Identify potential lock treatment options to prevent movement of aquatic invasive species through the Chicago Area Waterways System (CAWS)

USGS Publications Warehouse

Hubert, Terrance D.; Boogaard, Michael A.; Fredricks, Kim T.

2016-01-14

Compatibility of the various options was also evaluated to assess the possibility that options could be combined to enhance efficacy. Engineering requirements were not considered as part of this evaluation. The available information suggests that hot water at 43 °C and ozone are the most feasible options.

Options for management of municipal solid waste in New York City: A preliminary comparison of health risks and policy implications

PubMed Central

Moy, Pearl; Krishnan, Nikhil; Ulloa, Priscilla; Cohen, Steven; Brandt-Rauf, Paul W.

2008-01-01

Landfill disposal and waste-to-energy (WTE) incineration remain the two principal options for managing municipal solid waste (MSW). One critical determinant of the acceptability of these options is the different health risks associated with each. In this analysis relying on published data and exposure modeling, we have performed health risk assessments for landfill disposal versus WTE treatment options for the management of New York City’s MSW. These are based on the realistic scenario of using a waste transfer station (WTS) in Brooklyn and then transporting the untreated MSW by truck to a landfill in Pennsylvania or using a WTE facility in Brooklyn and then transporting the resultant ash by truck to a landfill in Pennsylvania. The overall results indicate that the individual cancer risks for both options would be considered generally acceptable, although the risk from landfilling is approximately 5 times greater than from WTE treatment; the individual non-cancer health risks for both options would be considered generally unacceptable, although once again the risk from landfilling is approximately 5 times greater than from WTE treatment. If one considers only the population in Brooklyn that would be directly affected by the siting of either a WTS or a WTE facility in their immediate neighborhood, individual cancer and non-cancer health risks for both options would be considered generally acceptable, but risks for the former remain considerably higher than for the latter. These results should be considered preliminary due to several limitations of this study such as: consideration of risks only from inhalation exposures; assumption that only volume and not composition of the waste stream is altered by WTE treatment; reliance on data from the literature rather than actual measurements of the sites considered, assuming comparability of the sites. However, the results of studies such as this, in conjunction with ecological, socioeconomic and equity considerations, should prove useful to environmental managers, regulators, policy makers, community representatives and other stakeholders in making sound and acceptable decisions regarding the optimal handling of MSW. PMID:17379391

CHOICE (Considering Honest Options in Career Exploration).

ERIC Educational Resources Information Center

Langford, Carolyn

The Considering Honest Options in Career Exploration (CHOICE) program is a career decision-making plan designed to assist counselors and teachers in helping high school juniors and seniors develop specific written career plans that they can implement after high school. This guide includes an overview of CHOICE and three CHOICE learning modules.…

Inservice Elementary and Middle School Teachers' Conceptions of Photosynthesis and Respiration

NASA Astrophysics Data System (ADS)

Krall, Rebecca Mcnall; Lott, Kimberly H.; Wymer, Carol L.

2009-02-01

The purpose of this descriptive study was to investigate inservice elementary and middle school teachers’ conceptions of photosynthesis and respiration, basic concepts they are expected to teach. A forced-choice instrument assessing selected standards-based life science concepts with non-scientific conceptions embedded in distracter options was utilized to assess 76 inservice elementary and middle school teachers from the central Appalachian region. Outcomes from four tasks assessing photosynthesis and respiration concepts are discussed. Findings revealed similarities between non-scientific conceptions the teachers demonstrated and non-scientific conceptions reported in the research literature on elementary and middle school students’ understanding of the concepts. Findings also informed subsequent inservice teacher professional development efforts in life science and the development of a biology course for preservice elementary teachers.

12-hour shifts: an ethical dilemma for the nurse executive.

PubMed

Lorenz, Susan G

2008-06-01

Flexible work hours, including 12-hour shifts, have become a common scheduling option for nurses. The author explores whether 12-hour shifts are an ethical scheduling option for nurses because recent research suggests that 12-hour shifts are a potential hazard to patients. A multistep model for ethical decision making, reflecting the concept of procedural justice, is used to examine this issue.

75 FR 26738 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-12

... Considered: Agenda: (1) Consideration of the trading of futures and binary options based on motion picture... revenues collared futures and binary option contracts, and the Cantor Exchange (``Cantor'') The Expendables... related to MDEX's Takers opening weekend motion picture revenues collared futures and binary option...

Effective Media Use: Using Film and Television to Instruct an Organizational Behavior Course

ERIC Educational Resources Information Center

Kernodle, Tom

2009-01-01

Media can be used to effectively teach Organizational Behavior (OB) concepts at the college level. University instructors have the option to employ several different methods of teaching in order to convey course concepts in the classroom. This article describes the effectiveness that five particular pieces of media can have on active learning in…

Concept Six Year-Round School Plan. A Simulation Notebook.

ERIC Educational Resources Information Center

White, William

Concept 6, a new program designed to cope with burgeoning enrollments and a shortage of classroom space in Jefferson County, Colorado, keeps school buildings in use 250 days and divides the school year into six terms of instruction. Individual students attend classes four terms and choose their vacations during the other two. An option for a fifth…

A restoration practitioner's guide to the restoration gene pool concept

Treesearch

Thomas A. Jones; Thomas A. Monaco

2007-01-01

Choosing plant materials for each desired species is often one of the most difficult steps in developing a restoration plan. The Restoration Gene Pool concept was developed to clarify the options available to the ecological restoration practitioner in terms of plant materials. We present a decision-making flowchart incorporating the issues delineated in the Restoration...

Space station systems analysis study. Part 3: Documentation. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

1977-01-01

The space stations systems analysis study is summarized. A cost efffective system concept capable of meeting a broad spectrum of mission requirements was developed. Candidate objectives were reviewed and implementation requirements were defined. Program options for both low earth and geosynchronous orbits were examined. Space construction concepts were analyzed and defined in detail.

76 FR 53705 - Notice To Rescind a Notice of Intent To Prepare an Environmental Impact Statement (EIS), Ada...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-29

... new concept are not significant and do not warrant an EIS. Recommendations for improvements along this... with several concepts derived from previous planning efforts. Then a wide range of route options were...) technology such as closed caption television cameras, speed detectors, and other hardware and software...

75 FR 38164 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-01

... time before the opening of trading in the underlying security when the Hybrid System will accept orders... related language in CBOE Rule 4.18 because the concept of leasing memberships no longer exists after the... Holder''). The Exchange is proposing to delete references to the concept of registering a membership for...

Improving Student Understanding of Lipids Concepts in a Biochemistry Course Using Test-Enhanced Learning

ERIC Educational Resources Information Center

Horn, Savannah; Hernick, Marcy

2015-01-01

Test-enhanced learning has successfully been used as a means to enhance learning and promote knowledge retention in students. We have examined whether this approach could be used in a biochemistry course to enhance student learning about lipids-related concepts. Students were provided access to two optional learning modules with questions related…

New-Concept Part-Time Employment as a Work-Family Adaptive Strategy for Women Professionals with Small Children

ERIC Educational Resources Information Center

Hill, E. Jeffrey; Martinson, Vjollca; Ferris, Maria

2004-01-01

This study investigates how the option for new-concept part-time (NPT) employment influences the ability of mothers of preschool children working in professional occupations to successfully integrate work and family responsibilities. Female NPT professionals (n=279) and female full-time (FT) professionals (n=250) were compared. The NPT group…

The focus series: A collection of single-concept remote sensing educational materials

NASA Technical Reports Server (NTRS)

Davis, S. M.

1977-01-01

The FOCUS series is a collection of two-page foldout documents each consisting of a diagram or photograph and an extended option of three to four hundred words. The series was developed to present basic remote sensing concepts in a simple, concise way. Issues currently available are collected in this information note.

Habitation Concepts and Tools for Asteroid Missions and Commercial Applications

NASA Technical Reports Server (NTRS)

Smitherman, David

2010-01-01

In 2009 studies were initiated in response to the Augustine Commission s review of the Human Spaceflight Program to examine the feasibility of additional options for space exploration beyond the lunar missions planned in the Constellation Program. One approach called a Flexible Path option included possible human missions to near-Earth asteroids. This paper presents an overview of possible asteroid missions with emphasis on the habitation options and vehicle configurations conceived for the crew excursion vehicles. One launch vehicle concept investigated for the Flexible Path option was to use a dual launch architecture that could serve a wide variety of exploration goals. The dual launch concept used two medium sized heavy lift launch vehicles for lunar missions as opposed to the single Saturn V architecture used for the Apollo Program, or the one-and-a-half vehicle Ares I / Ares V architecture proposed for the Constellation Program. This dual launch approach was studied as a Flexible Path option for lunar missions and for possible excursions to other destinations like geosynchronous earth orbiting satellites, Lagrange points, and as presented in this paper, asteroid rendezvous. New habitation and exploration systems for the crew are presented that permit crew sizes from 2 to 4, and mission durations from 100 to 360 days. Vehicle configurations are presented that include habitation systems and tools derived from International Space Station (ISS) experience and new extra-vehicular activity tools for asteroid exploration, Figure 1. Findings from these studies and as presented in this paper indicate that missions to near-Earth asteroids appear feasible in the near future using the dual launch architecture, the technologies under development from the Constellation Program, and systems derived from the current ISS Program. In addition, the capabilities derived from this approach that are particularly beneficial to the commercial sector include human access to geosynchronous orbit and the Lagrange points with new tools for satellite servicing and in-space assembly.

A Summary of NASA Architecture Studies Utilizing Fission Surface Power Technology

NASA Technical Reports Server (NTRS)

Mason, Lee; Poston, Dave

2010-01-01

Beginning with the Exploration Systems Architecture Study in 2005, NASA has conducted various mission architecture studies to evaluate implementation options for the U.S. Space Policy (formerly the Vision for Space Exploration). Several of the studies examined the use of Fission Surface Power (FSP) systems for human missions to the lunar and Martian surface. This paper summarizes the FSP concepts developed under four different NASA-sponsored architecture studies: Lunar Architecture Team, Mars Architecture Team, Lunar Surface Systems/Constellation Architecture team, and International Architecture Working Group-Power Function team. The results include a summary of FSP design characteristics, a compilation of mission-compatible FSP configuration options, and an FSP concept-of-operations that is consistent with the overall mission objectives.

Satellite Power Study (SPS) concept definition study (Exhibit D). Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

Hanley, G. M.

1981-01-01

Efforts concentrated on updating of the Rockwell reference concept, definition of new system options, studies of special emphasis topics, further definition of the transportation system, and further program definition. The Rockwell reference satellite concept has a gallium arsenide (GaAs) solar cell array having flat concentrators with an effective concentration ratio of 1.83at end of life. Alternatives to this concept includes solid state power amplifiers or magnetrons for dc/RF conversion and multibandgap solar cells for solar to dc energy conversion. Two solid state concepts were studied. It was determined that the magnetron approach was the lowest mass and cost system.

Energy Conversion and Storage Requirements for Hybrid Electric Aircraft

NASA Technical Reports Server (NTRS)

Misra, Ajay

2016-01-01

Among various options for reducing greenhouse gases in future large commercial aircraft, hybrid electric option holds significant promise. In the hybrid electric aircraft concept, gas turbine engine is used in combination with an energy storage system to drive the fan that propels the aircraft, with gas turbine engine being used for certain segments of the flight cycle and energy storage system being used for other segments. The paper will provide an overview of various energy conversion and storage options for hybrid electric aircraft. Such options may include fuel cells, batteries, super capacitors, multifunctional structures with energy storage capability, thermoelectric, thermionic or a combination of any of these options. The energy conversion and storage requirements for hybrid electric aircraft will be presented. The role of materials in energy conversion and storage systems for hybrid electric aircraft will be discussed.

Familiy Planning and Pregnancy

MedlinePlus

... should be managed to reduce risks to both mother and child; the options available for conception , prenatal diagnosis , and fetal sex determination . Updated November 2012 Bleeding Disorders The Clotting ...

75 FR 49475 - Petroleum Wax Candles From the People's Republic of China: Preliminary Results of Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-13

... prior scope rulings, refers to candles that are in the shapes of identifiable objects, or are holiday... 30686 (August 28, 1996) (``Order''). Option A: The Department would consider all candle shapes...-related art. All other candle shapes would be considered outside of the scope of the Order. Option B: The...

Flight operations payload training for crew and support personnel. Task 3: Inflight operations and training for payloads

NASA Technical Reports Server (NTRS)

Beardslee, R. F.

1976-01-01

Various degrees of Commander/Pilot involvement in on-orbit operation of payloads are examined. Constraints and limitations resulting from their participation or affecting their ability to participate are identified. Four options, each representing a different set of involvement depths and concepts are analyzed. Options identified are boundaries around extremes in Commander/Pilot payload involvement. Real world choices may fall somewhere in between, but for the purposes of this study the options as represented provide a matrix from which logical and practical decisions can be made about crew participation in payload operations.

Space Civil Engineering option - A progress report

NASA Technical Reports Server (NTRS)

Criswell, Marvin E.; Sadeh, Willy Z.

1992-01-01

Space Civil Engineering is an emerging engineering discipline that focuses on extending and expanding Civil Engineering to the development, operation, and maintenance of infrastructures on celestial bodies. Space Civil Engineering is presently being developed as a new discipline within the Department of Civil Engineering at Colorado State University and with support of the NASA Space Grant College Program. Academic programs geared toward creating Space Civil Engineering Options at both undergraduate and graduate levels are being formulated. Basic ideas and concepts and the current status of the curriculum in the Space Civil Engineering Option primarily at the undergraduate level are presented.

Understanding how prostate cancer patients value the current treatment options for metastatic castration resistant prostate cancer.

PubMed

Benidir, Tarik; Hersey, Karen; Finelli, Antonio; Hamilton, Rob; Joshua, Anthony M; Kulkarni, Girish; Zlotta, Alexandre; Fleshner, Neil

2018-05-01

Several new compounds are now available for castration resistant prostate cancer (CRPC). Individual costs range between $40,000 and $93,000 with mean survival extensions from 2.4 to 4.8 months. Currently, it remains unclear how patients with prostate cancer (PCa) value the effect of these therapies in the setting of CRPC. To assess patient understanding of core cancer concepts, opinions on the cost and overall benefit of CRPC drugs, whether out-of-pocket costs would change opinions and whether patients would ultimately opt out of CRPC drug treatment for an end-of-life (EOL) premium. We conducted a qualitative survey among patients with various PCa states ranging from active surveillance to CRPC and from various familial, financial and educational demographics. Through a series of hypothetical scenarios, we extrapolated opinions on CRPC drug value, efficacy and monetary worth. We assessed patient willingness to accept an EOL ($50,000) premium in lieu of CRPC drug treatment. Statistically, chi-squared analysis and Fisher's exact test were used when appropriate. In total, 103 patients completed the questionnaire, one-half of whom did not understand "advanced PCa" state and more than one-third of the concept of palliative care despite multiple meetings with Urologists. Patients willingness-to-pay and proposed drug value was higher than that accepted by government when government funded, with costs exceeding $250,000 per person, but lower than that accepted by government when self-funded. A majority (60%) would accept/consider the EOL premium in the setting of CRPC. Patients with higher education were more skeptical about CRPC drug value and more likely to accept the EOL premium (P = 0.003.) CONCLUSION: Patients have an incomplete understanding of their own disease prognosis and its therapeutic options. This ultimately influences patient decision-making. Education, income and out-of-pocket costs diminished opinion of CRPC drugs considerably. As such, an EOL premium should be considered in subsets of patients. Crown Copyright © 2018. Published by Elsevier Inc. All rights reserved.

Raising Nuclear Thermal Propulsion (NTP) Technology Readiness Above 3

NASA Technical Reports Server (NTRS)

Gerrish, Harold P., Jr.

2014-01-01

NTP development is currently supported by the NASA program office "Advanced Exploration Systems". The concept is a main propulsion option being considered for human missions to Mars in the 2030's. Major NTP development took place in the 1960's and 1970's under the Rover/NERVA program. The technology had matured to TRL 6 and was preparing to go to TRL 7 with a prototype flight engine before the program was cancelled. Over the last 40 years, a variety of continuations started, but only lasted a few years each. The Rover/NERVA infrastructure is almost all gone. The only remains are a few pieces of hardware, final reports and a few who worked the Rover/NERVA. Two types of nuclear fuel are being investigated to meet the current engine design specific impulse of 900 seconds compared to approximately 850 seconds demonstrated during Rover/NERVA. One is a continuation of composite fuel with new coatings to better control mid-band corrosion. The other type is a CERMET fuel made of Tungsten and UO2. Both fuels are being made from Rover/NERVA lessons learned, but with slightly different recipes to increase fuel endurance at higher operating temperatures. The technology readiness level (TRL) of these current modified reactor fuels is approximately TRL 3. To keep the development cost low and help mature the TRL level past 4 quickly, a few special non-nuclear test facilities have been made to test surrogate fuel, with depleted uranium, as coupons and full length elements. Both facilities utilize inductive heating and are licensed to handle depleted uranium. TRL 5 requires exposing the fuel to a nuclear environment and TRL 6 requires a prototype ground or flight engine system test. Currently, three different NTP ground test facility options are being investigated: exhaust scrubber, bore hole, and total exhaust containment. In parallel, a prototype flight demonstration test is also being studied. The first human mission to Mars in the 2030's is currently 2033. For an advanced propulsion concept to be seriously considered for use, the engine development plans need to show it is feasible and affordable to reach TRL 8 by 2027 and can be qualified for human mission use.

Understanding Consistency Maintenance in Service Discovery Architectures in Response to Message Loss

DTIC Science & Technology

2002-07-01

manager (SM), and (3) service cache manager ( SCM ). The SCM is an optional element not supported by all discovery protocols. These components participate...the SCM operates as an intermediary, matching advertised SDs of SMs to requirements provided by SUs. Table 1 shows how these general concepts map...Service DescriptionService ItemService Description (SD) Directory Service Agent (optional) not applicableLookup ServiceService Cache Manager ( SCM

Cross-Domain Synergy: Using Artillery in the Fight for Sea Control

DTIC Science & Technology

2017-04-28

weapon systems designed to contest operational access to joint forces have given many countries low-cost options to prevent intrusion into their...systems designed to contest operational access to joint forces have given many countries low-cost options to prevent intrusion into their...1 The concept of anti-access is not new. The Great Wall of China and Athenian walls demonstrate this strategy has existed for

Mars lander survey

NASA Technical Reports Server (NTRS)

Stump, William R.; Babb, Gus R.; Davis, Hubert P.

1986-01-01

The requirements, issues, and design options are reviewed for manned Mars landers. Issues such as high 1/d versus low 1/d shape, parking orbit, and use of a small Mars orbit transfer vehicle to move the lander from orbit to orbit are addressed. Plots of lander mass as a function of Isp, destination orbit, and cargo up and down, plots of initial stack mass in low Earth orbit as a function of lander mass and parking orbit, detailed weight statements, and delta V tables for a variety of options are included. Lander options include a range from minimum landers up to a single stage reusable design. Mission options include conjunction and Venus flyby trajectories using all-cryogenic, hybrid, NERVA, and Mars orbit aerobraking propulsion concepts.

Economic evaluation of preventive dental programs: what can they tell us?

PubMed

Morgan, Mike; Mariño, Rodrigo; Wright, Clive; Bailey, Denise; Hopcraft, Matthew

2012-10-01

The role of public health program planners is to determine the effectiveness of public health programs, what recommendations should be made, what future initiatives should be taken, and what policies should be developed. At a basic level, to choose between competing alternatives, two characteristics of an intervention must be considered; these are its outcome and its cost. Based on cost and outcome, planners must select the option that offers the most advantages. Economic evaluation is commonly adopted by decision makers in the health sector to investigate the effectiveness of public health programs and to help plan future initiatives. Economic evaluation assists decision makers who must weigh the information it provides in the context of many and often competing options. In this way, an economic evaluation is an aid to decision making rather than the decision itself. Economic evaluation is becoming essential for informed decision making, with potential implications for public health policy and practice and for clinical practice too. While economic evaluations are commonly used in decision-making processes about health programs, few examples exist in the oral health literature. In the case of preventive oral health programs, economic analysis is often difficult, largely because it makes demands on epidemiological and demographic data that are hard to meet. This study will address the concepts and tools required to conduct economic evaluations of prevention programs. The emphasis will be on oral health and preventive dental programs, although the concepts presented could be useful for other public health programs by practitioners and managers with the aim of producing effective and efficient oral health programs. © 2012 John Wiley & Sons A/S.

Quantifying induced effects of subsurface renewable energy storage

NASA Astrophysics Data System (ADS)

Bauer, Sebastian; Beyer, Christof; Pfeiffer, Tilmann; Boockmeyer, Anke; Popp, Steffi; Delfs, Jens-Olaf; Wang, Bo; Li, Dedong; Dethlefsen, Frank; Dahmke, Andreas

2015-04-01

New methods and technologies for energy storage are required for the transition to renewable energy sources. Subsurface energy storage systems such as salt caverns or porous formations offer the possibility of hosting large amounts of energy or substance. When employing these systems, an adequate system and process understanding is required in order to assess the feasibility of the individual storage option at the respective site and to predict the complex and interacting effects induced. This understanding is the basis for assessing the potential as well as the risks connected with a sustainable usage of these storage options, especially when considering possible mutual influences. For achieving this aim, in this work synthetic scenarios for the use of the geological underground as an energy storage system are developed and parameterized. The scenarios are designed to represent typical conditions in North Germany. The types of subsurface use investigated here include gas storage and heat storage in porous formations. The scenarios are numerically simulated and interpreted with regard to risk analysis and effect forecasting. For this, the numerical simulators Eclipse and OpenGeoSys are used. The latter is enhanced to include the required coupled hydraulic, thermal, geomechanical and geochemical processes. Using the simulated and interpreted scenarios, the induced effects are quantified individually and monitoring concepts for observing these effects are derived. This presentation will detail the general investigation concept used and analyze the parameter availability for this type of model applications. Then the process implementation and numerical methods required and applied for simulating the induced effects of subsurface storage are detailed and explained. Application examples show the developed methods and quantify induced effects and storage sizes for the typical settings parameterized. This work is part of the ANGUS+ project, funded by the German Ministry of Education and Research (BMBF).

Technical - Economic Research for Passive Buildings

NASA Astrophysics Data System (ADS)

Miniotaite, Ruta

2017-10-01

A newly constructed passive house must save 80 % of heat resources; otherwise it is not a passive house. The heating energy demand of a passive building is less than 15 kWh/m2 per year. However, a passive house is something more than just an energy-saving house. This concept involves sustainable, high-quality, valuable, healthy and durable construction. Features of a passive house: high insulation of envelope components, high-quality windows, good tightness of the building, regenerative ventilation system and elimination of thermal bridges. The Energy Performance of Buildings Directive (EPBD) 61 requires all new public buildings to become near-zero energy buildings by 2019 and will be extended to all new buildings by 2021. This concept involves sustainable, high-quality, valuable, healthy and durable construction. Foundation, walls and roofs are the most essential elements of a house. The type of foundation for a private house is selected considering many factors. The article examines technological and structural solutions for passive buildings foundation, walls and roofs. The technical-economic comparison of the main structures of a passive house revealed that it is cheaper to install an adequately designed concrete slab foundation than to build strip or pile foundation and the floor separately. Timber stud walls are the cheapest wall option for a passive house and 45-51% cheaper compared to other options. The comparison of roofs and ceilings showed that insulation of the ceiling is 25% more efficient than insulation of the roof. The comparison of the main envelope elements efficiency by multiple-criteria evaluation methods showed that it is economically feasible to install concrete slab on ground foundation, stud walls with sheet cladding and a pitched roof with insulated ceiling.

Evaluating Safer Conception Options for HIV-Serodiscordant Couples (HIV-Infected Female/HIV-Uninfected Male): A Closer Look at Vaginal Insemination

PubMed Central

Mmeje, Okeoma; Cohen, Craig R.; Cohan, Deborah

2012-01-01

HIV serodiscordant couples represent at least half of all HIV-affected couples worldwide. Many of these couples have childbearing desires. Safer methods of conception may allow for pregnancy while minimizing the risk of sexual transmission of HIV. In serodiscordant partnerships with an HIV-infected female and HIV-uninfected male, vaginal insemination of a partner's semen during the fertile period coupled with 100% condom use may be the safest method of conception. PMID:22927714

Basic Lessons in ORA and AutoMap 2012

DTIC Science & Technology

2012-06-11

boy named Dave. He has 2 balls. 1 ball is red. 1 ball is blue. milkAndCookies.txt: Dave wants milk and cookies. He drives to the store. He then buys... milk and cookies. 2. Create Concept List From the Pull Down Menu select Generate => Concept List => Concept List (per text). Navigate to where you...the thesaurus. Using the ThesauriContentOnly option You create a Meta-Network (Carley, 200) with the one-grams dog, cow , and farm. If you are going

Satellite power systems (SPS) concept definition study. Volume 1: Executive summary

NASA Technical Reports Server (NTRS)

Hanley, G. M.

1980-01-01

System definition studies resulted in a further definition of the reference system using gallium arsenide solar arrays, analysis of alternative subsystem options for the reference concept, preliminary solid state microwave concept studies, and an environmental analysis of laser transmission systems. The special emphasis studies concentrated on satellite construction, satellite construction base definition, satellite construction base construction, and rectenna construction. Major emphasis in the transportation studies was put on definition of a two stage parallel burn, vertical takeoff/horizontal landing concept. The electric orbit transfer vehicle was defined in greater detail. Program definition included cost analyses and schedule definition.

Mission and Design Sensitivities for Human Mars Landers Using Hypersonic Inflatable Aerodynamic Decelerators

NASA Technical Reports Server (NTRS)

Polsgrove, Tara P.; Thomas, Herbert D.; Collins, Tim; Dwyer Cianciolo, Alicia; Samareh, Jamshid

2017-01-01

Landing humans on Mars is one of NASA's long term goals. The Evolvable Mars Campaign (EMC) is focused on evaluating architectural trade options to define the capabilities and elements needed for a sustainable human presence on the surface of Mars. The EMC study teams have considered a variety of in-space propulsion options and surface mission options. As we seek to better understand how these choices affect the performance of the lander, this work informs and influences requirements for transportation systems to deliver the landers to Mars and enable these missions. This paper presents the effects of mission and vehicle design options on lander mass and performance. Beginning with Earth launch, options include fairing size assumptions, co-manifesting other elements with the lander, and Earth-Moon vicinity operations. Capturing into Mars orbit using either aerocapture or propulsive capture is assessed. For entry, descent, and landing both storable as well as oxygen and methane propellant combinations are considered, engine thrust level is assessed, and sensitivity to landed payload mass is presented. This paper focuses on lander designs using the Hypersonic Inflatable Aerodynamic Decelerators (HIAD), one of several entry system technologies currently considered for human missions.

Advanced GPS Technologies (AGT)

DTIC Science & Technology

2015-05-01

Distribution A GPS Ill Developmental Optical Clock Deployable Antenna Concept 3 \\.J Science and Technology for GPS •:• Spacecraft • AFRL has funded a...Digital Waveform Generators New antenna concepts Supporting electronics Algorithms and new signal combining methods Satellite bus technologies...GPS Military High Gain Antenna Developing Options for Ground Testing 1) Deployable phased array • Low profile element • High efficiency phase

78 FR 65741 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-01

... Effectiveness of a Proposed Rule Change To Adopt the Concept of a ``Responsible Person'' on the CBOE Stock... Exchange proposes to adopt the concept of a ``Responsible Person'' on its CBOE Stock Exchange (``CBSX... impediments to and perfect the mechanism of a free and open market and a national market system, and, in...

Study design options in evaluating gene-environment interactions: practical considerations for a planned case-control study of pediatric leukemia.

PubMed

Goodman, Michael; Dana Flanders, W

2007-04-01

We compare methodological approaches for evaluating gene-environment interaction using a planned study of pediatric leukemia as a practical example. We considered three design options: a full case-control study (Option I), a case-only study (Option II), and a partial case-control study (Option III), in which information on controls is limited to environmental exposure only. For each design option we determined its ability to measure the main effects of environmental factor E and genetic factor G, and the interaction between E and G. Using the leukemia study example, we calculated sample sizes required to detect and odds ratio (OR) of 2.0 for E alone, an OR of 10 for G alone and an interaction G x E of 3. Option I allows measuring both main effects and interaction, but requires a total sample size of 1,500 cases and 1,500 controls. Option II allows measuring only interaction, but requires just 121 cases. Option III allows calculating the main effect of E, and interaction, but not the main effect of G, and requires a total of 156 cases and 133 controls. In this case, the partial case-control study (Option III) appears to be more efficient with respect to its ability to answer the research questions for the amount of resources required. The design options considered in this example are not limited to observational epidemiology and may be applicable in studies of pharmacogenomics, survivorship, and other areas of pediatric ALL research.

The 1980 V-TECS Marketing Study.

ERIC Educational Resources Information Center

Hattwick, Richard E.; And Others

The Vocational-Technical Education Consortium of States (V-TECS) conducted a marketing study that considered the implications of six options for the organization's future. The first option is continuation of the status quo, which is dangerous because existing members may leave the consortium. The second option is the status quo combined with an…

Other Remedy Options Evaluated

EPA Pesticide Factsheets

EPA considered several remedy options for reducing emissions from electric generating units (EGUs) that contribute significantly to nonattainment or interfere with maintenance of the air quality standards by downwind states.

Older People's Discourses About Euthanasia and Assisted Suicide: A Foucauldian Exploration.

PubMed

Lamers, Carolien P T; Williams, Rebecca R

2016-12-01

This study aims to contribute an alternative understanding of the position of older people in the euthanasia and assisted suicide (EU/AS) debate. Seven interviews were analyzed using Foucauldian discourse analysis, to explore concepts like knowledge, power, subjectification and surveillance. The participants presented a "confused and conflicted" discourse, expressing the view that EU/AS is a family affair, whilst also articulating a strong sense of self-determination. Although a discourse of the medicalization of dying through medical control and surveillance was endorsed, an alternative discourse of "dying outside the medical gaze" emerged. Participants, who were in favor of EU/AS, felt "voiceless," as apparent double standards were applied in the debate, and powerful others, for example, physicians and politicians, seemed reluctant to engage. Within an "aged death" discourse, the anticipated dependency on poor care from (professional) others, made participants consider EU/AS as ways of avoiding this stage of life and the associated loss of dignity. By using Foucauldian discourse analysis, alternative power relationships were revealed which might give a different interpretation to the concept of the "slippery slope." Societal discourses and related behaviors, which devalue the dependent and old, might become internalized by older people, leading them to consider EU/AS as preferable end-of-life options. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Information basis for developing comprehensive waste management system-US-Japan joint nuclear energy action plan waste management working group phase I report.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nutt, M.; Nuclear Engineering Division

2010-05-25

The activity of Phase I of the Waste Management Working Group under the United States - Japan Joint Nuclear Energy Action Plan started in 2007. The US-Japan JNEAP is a bilateral collaborative framework to support the global implementation of safe, secure, and sustainable, nuclear fuel cycles (referred to in this document as fuel cycles). The Waste Management Working Group was established by strong interest of both parties, which arise from the recognition that development and optimization of waste management and disposal system(s) are central issues of the present and future nuclear fuel cycles. This report summarizes the activity of themore » Waste Management Working Group that focused on consolidation of the existing technical basis between the U.S. and Japan and the joint development of a plan for future collaborative activities. Firstly, the political/regulatory frameworks related to nuclear fuel cycles in both countries were reviewed. The various advanced fuel cycle scenarios that have been considered in both countries were then surveyed and summarized. The working group established the working reference scenario for the future cooperative activity that corresponds to a fuel cycle scenario being considered both in Japan and the U.S. This working scenario involves transitioning from a once-through fuel cycle utilizing light water reactors to a one-pass uranium-plutonium fuel recycle in light water reactors to a combination of light water reactors and fast reactors with plutonium, uranium, and minor actinide recycle, ultimately concluding with multiple recycle passes primarily using fast reactors. Considering the scenario, current and future expected waste streams, treatment and inventory were discussed, and the relevant information was summarized. Second, the waste management/disposal system optimization was discussed. Repository system concepts were reviewed, repository design concepts for the various classifications of nuclear waste were summarized, and the factors to consider in repository design and optimization were then discussed. Japan is considering various alternatives and options for the geologic disposal facility and the framework for future analysis of repository concepts was discussed. Regarding the advanced waste and storage form development, waste form technologies developed in both countries were surveyed and compared. Potential collaboration areas and activities were next identified. Disposal system optimization processes and techniques were reviewed, and factors to consider in future repository design optimization activities were also discussed. Then the potential collaboration areas and activities related to the optimization problem were extracted.« less

Trajectory Options for a Potential Mars Mission Combining Orbiting Science, Relay and a Sample Return Rendezvous Demonstration

NASA Technical Reports Server (NTRS)

Guinn, Joseph R.; Kerridge, Stuart J.; Wilson, Roby S.

2012-01-01

Mars sample return is a major scientific goal of the 2011 US National Research Council Decadal Survey for Planetary Science. Toward achievement of this goal, recent architecture studies have focused on several mission concept options for the 2018/2020 Mars launch opportunities. Mars orbiters play multiple roles in these architectures such as: relay, landing site identification/selection/certification, collection of on-going or new measurements to fill knowledge gaps, and in-orbit collection and transportation of samples from Mars to Earth. This paper reviews orbiter concepts that combine these roles and describes a novel family of relay orbits optimized for surface operations support. Additionally, these roles provide an intersection of objectives for long term NASA science, human exploration, technology development and international collaboration.

Boulder Capture System Design Options for the Asteroid Robotic Redirect Mission Alternate Approach Trade Study

NASA Technical Reports Server (NTRS)

Belbin, Scott P.; Merrill, Raymond G.

2014-01-01

This paper presents a boulder acquisition and asteroid surface interaction electromechanical concept developed for the Asteroid Robotic Redirect Mission (ARRM) option to capture a free standing boulder on the surface of a 100 m or larger Near Earth Asteroid (NEA). It details the down select process and ranking of potential boulder capture methods, the evolution of a simple yet elegant articulating spaceframe, and ongoing risk reduction and concept refinement efforts. The capture system configuration leverages the spaceframe, heritage manipulators, and a new microspine technology to enable the ARRM boulder capture. While at the NEA it enables attenuation of terminal descent velocity, ascent to escape velocity, boulder collection and restraint. After departure from the NEA it enables, robotic inspection, sample caching, and crew Extra Vehicular Activities (EVA).

Lunar lander and return propulsion system trade study

NASA Technical Reports Server (NTRS)

Hurlbert, Eric A.; Moreland, Robert; Sanders, Gerald B.; Robertson, Edward A.; Amidei, David; Mulholland, John

1993-01-01

This trade study was initiated at NASA/JSC in May 1992 to develop and evaluate main propulsion system alternatives to the reference First Lunar Outpost (FLO) lander and return-stage transportation system concept. Thirteen alternative configurations were developed to explore the impacts of various combinations of return stage propellants, using either pressure or pump-fed propulsion systems and various staging options. Besides two-stage vehicle concepts, the merits of single-stage and stage-and-a-half options were also assessed in combination with high-performance liquid oxygen and liquid hydrogen propellants. Configurations using an integrated modular cryogenic engine were developed to assess potential improvements in packaging efficiency, mass performance, and system reliability compared to non-modular cryogenic designs. The selection process to evaluate the various designs was the analytic hierarchy process. The trade study showed that a pressure-fed MMH/N2O4 return stage and RL10-based lander stage is the best option for a 1999 launch. While results of this study are tailored to FLO needs, the design date, criteria, and selection methodology are applicable to the design of other crewed lunar landing and return vehicles.

Computational Study of a McDonnell Douglas Single-Stage-to-Orbit Vehicle Concept for Aerodynamic Analysis

NASA Technical Reports Server (NTRS)

Prabhu, Ramadas K.

1996-01-01

This paper presents the results of a computational flow analysis of the McDonnell Douglas single-stage-to-orbit vehicle concept designated as the 24U. This study was made to determine the aerodynamic characteristics of the vehicle with and without body flaps over an angle of attack range of 20-40 deg. Computations were made at a flight Mach number of 20 at 200,000 ft. altitude with equilibrium air, and a Mach number of 6 with CF4 gas. The software package FELISA (Finite Element Langley imperial College Sawansea Ames) was used for all the computations. The FELISA software consists of unstructured surface and volume grid generators, and inviscid flow solvers with (1) perfect gas option for subsonic, transonic, and low supersonic speeds, and (2) perfect gas, equilibrium air, and CF4 options for hypersonic speeds. The hypersonic flow solvers with equilibrium air and CF4 options were used in the present studies. Results are compared with other computational results and hypersonic CF4 tunnel test data.

H2@Scale Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruth, Mark

2017-07-12

'H2@Scale' is a concept based on the opportunity for hydrogen to act as an intermediate between energy sources and uses. Hydrogen has the potential to be used like the primary intermediate in use today, electricity, because it too is fungible. This presentation summarizes the H2@Scale analysis efforts performed during the first third of 2017. Results of technical potential uses and supply options are summarized and show that the technical potential demand for hydrogen is 60 million metric tons per year and that the U.S. has sufficient domestic resources to meet that demand. A high level infrastructure analysis is also presentedmore » that shows an 85% increase in energy on the grid if all hydrogen is produced from grid electricity. However, a preliminary spatial assessment shows that supply is sufficient in most counties across the U.S. The presentation also shows plans for analysis of the economic potential for the H2@Scale concept. Those plans involve developing supply and demand curves for potential hydrogen generation options and as compared to other options for use of that hydrogen.« less

Extended duration orbiter study: CO2 removal and water recovery

NASA Technical Reports Server (NTRS)

Marshall, R. D.; Ellis, G. S.; Schubert, F. H.; Wynveen, R. A.

1979-01-01

Two electrochemical depolarized carbon dioxide concentrator subsystems were evaluated against baseline lithium hydroxide for (1) the baseline orbiter when expanded to accommodate a crew of seven (mission option one), (2) an extended duration orbiter with a power extension package to reduce fuel cell expendables (mission option two), and (3) an extended duration orbiter with a full capability power module to eliminate fuel cell expendables (mission option three). The electrochemical depolarized carbon dioxide concentrator was also compared to the solid amine regenerable carbon dioxide removal concept. Water recovery is not required for Mission Option One since sufficient water is generated by the fuel cells. The vapor compression distillation subsystem was evaluated for mission option two and three only. Weight savings attainable using the vapor compression distillation subsystem for water recovery versus on-board water storage were determined. Combined carbon dioxide removal and water recovery was evaluated to determine the effect on regenerable carbon dioxide removal subsystem selection.

Spacelab experiment computer study. Volume 1: Executive summary (presentation)

NASA Technical Reports Server (NTRS)

Lewis, J. L.; Hodges, B. C.; Christy, J. O.

1976-01-01

A quantitative cost for various Spacelab flight hardware configurations is provided along with varied software development options. A cost analysis of Spacelab computer hardware and software is presented. The cost study is discussed based on utilization of a central experiment computer with optional auxillary equipment. Groundrules and assumptions used in deriving the costing methods for all options in the Spacelab experiment study are presented. The groundrules and assumptions, are analysed and the options along with their cost considerations, are discussed. It is concluded that Spacelab program cost for software development and maintenance is independent of experimental hardware and software options, that distributed standard computer concept simplifies software integration without a significant increase in cost, and that decisions on flight computer hardware configurations should not be made until payload selection for a given mission and a detailed analysis of the mission requirements are completed.

Co-Optimization of Electricity Transmission and Generation Resources for Planning and Policy Analysis: Review of Concepts and Modeling Approaches

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krishnan, Venkat; Ho, Jonathan; Hobbs, Benjamin F.

2016-05-01

The recognition of transmission's interaction with other resources has motivated the development of co-optimization methods to optimize transmission investment while simultaneously considering tradeoffs with investments in electricity supply, demand, and storage resources. For a given set of constraints, co-optimized planning models provide solutions that have lower costs than solutions obtained from decoupled optimization (transmission-only, generation-only, or iterations between them). This paper describes co-optimization and provides an overview of approaches to co-optimizing transmission options, supply-side resources, demand-side resources, and natural gas pipelines. In particular, the paper provides an up-to-date assessment of the present and potential capabilities of existing co-optimization tools, andmore » it discusses needs and challenges for developing advanced co-optimization models.« less

Physiology undergraduate degree requirements in the U.S.

PubMed

VanRyn, Valerie S; Poteracki, James M; Wehrwein, Erica A

2017-12-01

Course-level learning objectives and core concepts for undergraduate physiology teaching exist. The next step is to consider how these resources fit into generalizable program-level guidelines for Bachelor of Science (BS) degrees in Physiology. In the absence of program-level guidelines for Physiology degree programs, we compiled a selective internal report to review degree requirements from 18 peer BS programs entitled "Physiology" in the United States (U.S.). There was a range of zero to three required semesters of math, physics, physics laboratory, general biology, biology laboratory, general chemistry, chemistry laboratory, organic chemistry, organic chemistry laboratory, biochemistry, biochemistry laboratory, anatomy, anatomy laboratory, core systems physiology, and physiology laboratory. Required upper division credits ranged from 11 to 31 and included system-specific, exercise and environmental, clinically relevant, pathology/disease-related, and basic science options. We hope that this information will be useful for all programs that consider themselves to be physiology, regardless of name. Reports such as this can serve as a starting point for collaboration among BS programs to improve physiology undergraduate education and best serve our students. Copyright © 2017 the American Physiological Society.

Material Requirements, Selection And Development for the Proposed JIMO SpacePower System

NASA Astrophysics Data System (ADS)

Ring, P. J.; Sayre, E. D.

2004-02-01

NASA is proposing a major new nuclear Space initiative-The Jupiter Icy Moons Orbiter (JIMO). A mission such as this inevitably requires a significant power source both for propulsion and for on-board power. Three reactor concepts, liquid metal cooled, heat pipe cooled and gas cooled are being considered together with three power conversion systems Brayton (cycle), Thermoelectric and Stirling cycles, and possibly Photo voltaics for future systems. Regardless of the reactor system selected it is almost certain that high temperature (materials), refractory alloys, will be required. This paper revisits the material selection options, reviewing the rationale behind the SP-100 selection of Nb-1Zr as the major cladding and structural material and considers the alternatives and developments needed for the longer duty cycle of the JIMO power supply. A side glance is also taken at the basis behind the selection of Uranium nitride fuel over UO2 or UC and a brief discussion of the reason for the selection of Lithium as the liquid metal coolant for SP-100 over other liquid metals.

Economic feasibility study for new technological alternatives in wastewater treatment processes: a review.

PubMed

Molinos-Senante, María; Hernández-Sancho, Francesc; Sala-Garrido, Ramón

2012-01-01

The concept of sustainability involves the integration of economic, environmental, and social aspects and this also applies in the field of wastewater treatment. Economic feasibility studies are a key tool for selecting the most appropriate option from a set of technological proposals. Moreover, these studies are needed to assess the viability of transferring new technologies from pilot-scale to full-scale. In traditional economic feasibility studies, the benefits that have no market price, such as environmental benefits, are not considered and are therefore underestimated. To overcome this limitation, we propose a new methodology to assess the economic viability of wastewater treatment technologies that considers internal and external impacts. The estimation of the costs is based on the use of cost functions. To quantify the environmental benefits from wastewater treatment, the distance function methodology is proposed to estimate the shadow price of each pollutant removed in the wastewater treatment. The application of this methodological approach by decision makers enables the calculation of the true costs and benefits associated with each alternative technology. The proposed methodology is presented as a useful tool to support decision making.

Foldit Biology

DTIC Science & Technology

2015-07-31

vicinity of the enzyme , searching for the active site; (iii) find the active site and position the substrate at it, triggering the catalysis . As the...visualization options. The Lysozyme example is used to introduce the concepts of how enzymes work, and use a view option to visualize the surface of the... enzyme , its active site and its substrate. It is also in this example that we introduce the Foldit Biology notion of a ‘protein state’. Each protein

Preliminary design of a supersonic Short-Takeoff and Vertical-Landing (STOVL) fighter aircraft

NASA Technical Reports Server (NTRS)

1990-01-01

A preliminary study of a supersonic short takeoff and vertical landing (STOVL) fighter is presented. Three configurations (a lift plus lift/cruise concept, a hybrid fan vectored thrust concept, and a mixed flow vectored thrust concept) were initially investigated with one configuration selected for further design analysis. The selected configuration, the lift plus lift/cruise concept, was successfully integrated to accommodate the powered lift short takeoff and vertical landing requirements as well as the demanding supersonic cruise and point performance requirements. A supersonic fighter aircraft with a short takeoff and vertical landing capability using the lift plus lift/cruise engine concept seems a viable option for the next generation fighter.

Shuttle-Derived Launch Vehicles' Capablities: An Overview

NASA Technical Reports Server (NTRS)

Rothschild, William J.; Bailey, Debra A.; Henderson, Edward M.; Crumbly, Chris

2005-01-01

Shuttle-Derived Launch Vehicle (SDLV) concepts have been developed by a collaborative team comprising the Johnson Space Center, Marshall Space Flight Center, Kennedy Space Center, ATK-Thiokol, Lockheed Martin Space Systems Company, The Boeing Company, and United Space Alliance. The purpose of this study was to provide timely information on a full spectrum of low-risk, cost-effective options for STS-Derived Launch Vehicle concepts to support the definition of crew and cargo launch requirements for the Space Exploration Vision. Since the SDLV options use high-reliability hardware, existing facilities, and proven processes, they can provide relatively low-risk capabilities to launch extremely large payloads to low Earth orbit. This capability to reliably lift very large, high-dollar-value payloads could reduce mission operational risks by minimizing the number of complex on-orbit operations compared to architectures based on multiple smaller launchers. The SDLV options also offer several logical spiral development paths for larger exploration payloads. All of these development paths make practical and cost-effective use of existing Space Shuttle Program (SSP) hardware, infrastructure, and launch and flight operations systems. By utilizing these existing assets, the SDLV project could support the safe and orderly transition of the current SSP through the planned end of life in 2010. The SDLV concept definition work during 2004 focused on three main configuration alternatives: a side-mount heavy lifter (approximately 77 MT payload), an in-line medium lifter (approximately 22 MT Crew Exploration Vehicle payload), and an in-line heavy lifter (greater than 100 MT payload). This paper provides an overview of the configuration, performance capabilities, reliability estimates, concept of operations, and development plans for each of the various SDLV alternatives. While development, production, and operations costs have been estimated for each of the SDLV configuration alternatives, these proprietary data have not been included in this paper.

The electrical power subsystem design for the high energy solar physics spacecraft concepts

NASA Technical Reports Server (NTRS)

Kulkarni, Milind

1993-01-01

This paper discusses the Electrical Power Subsystem (EPS) requirements, architecture, design description, performance analysis, and heritage of the components for two spacecraft concepts for the High Energy Solar Physics (HESP) Mission. It summarizes the mission requirements and the spacecraft subsystems and instrument power requirements, and it describes the EPS architecture for both options. A trade study performed on the selection of the solar cells - body mounted versus deployed panels - and the optimum number of panels is also presented. Solar cell manufacturing losses, array manufacturing losses, and the radiation and temperature effects on the GaAs/Ge and Si solar cells were considered part of the trade study and are included in this paper. Solar cell characteristics, cell circuit description, and the solar array area design are presented, as is battery sizing analysis performed based on the power requirements during launch and initial spacecraft operations. This paper discusses Earth occultation periods and the battery power requirements during this period as well as shunt control, battery conditioning, and bus regulation schemes. Design margins, redundancy philosophy, and predicted on-orbit battery and solar cell performance are summarized. Finally, the heritage of the components and technology risk assessment are provided.

Understanding and Addressing Socio-Cultural Barriers to Medical Male Circumcision in Traditionally Non-Circumcising Rural Communities in Sub-Saharan Africa

PubMed Central

Khumalo-Sakutukwa, Gertrude; Lane, Tim; van-Rooyen, Heidi; Chingono, Alfred; Humphries, Hilton; Timbe, Andrew; Fritz, Katherine; Chirowodza, Admire; Morin, Stephen F.

2013-01-01

Given the success of recent clinical trials establishing the safety and efficacy of adult medical male circumcision in Africa, attention has now shifted to barriers and facilitators to programmatic implementation in traditionally non-circumcising communities. In this study, we attempted to develop a fuller understanding of the role of cultural issues in the acceptance of adult circumcision. We conducted four focus group discussions with 28 participants in Mutoko in Zimbabwe, and 33 participants in Vulindlela, in KwaZulu-Natal, South Africa, as well as 19 key informant interviews in both settings. We found the concept of male circumcision to be an alien practice, particularly as expressed in the context of local languages. Cultural barriers included local concepts of ethnicity, social groups, masculinity, and sexuality. On the other hand, we found that concerns about the impact of HIV on communities resulted in willingness to consider adult male circumcision as an option if it would result in lowering the local burden of the epidemic. Adult medical male circumcision promotional messages that create a synergy between understandings of both traditional and medical circumcision will be more successful in these communities. PMID:23815101

"Something of the two of us". The emotionally loaded embryo disposition decision making of patients who view their embryo as a symbol of their relationship.

PubMed

Provoost, Veerle; Pennings, Guido; De Sutter, Petra; Dhont, Marc

2012-06-01

This paper describes a recently identified conception of the cryopreserved embryo as a symbol of one's relationship (SOR). A questionnaire was sent together with the embryo disposition decision (EDD) form to patients for whom embryos were cryopreserved at the department in Ghent, Belgium. We collected data on patient characteristics, their EDD attitudes and the reasons for their willingness or unwillingness to consider each of the disposition options (donation to others for reproduction, donation for science and discarding). The SOR view was found more often in patients who were less educated and whose last treatment was less than 3 years ago. Viewing the embryo as a SOR was not linked to more difficult decision making, but to more emotionally loaded decision making. In particular, patients with this view more often reported feelings of grief. This view was also linked to the outcome of the decision making process. The conception of the embryo as a SOR is part of an affective attitude towards embryos that has an impact on patients' disposition decisions. Alongside patients' values and principles, it is important that counselors acknowledge and clarify patients' affective conceptualizations.

Tricuspid Regurgitation – Medical Management and Evolving Interventional Concepts

PubMed Central

Beckhoff, Frederik; Alushi, Brunilda; Jung, Christian; Navarese, Eliano; Franz, Marcus; Kretzschmar, Daniel; Wernly, Bernhard; Lichtenauer, Michael; Lauten, Alexander

2018-01-01

Severe tricuspid regurgitation (TR) is a complex condition of the right ventricle (RV) and tricuspid valve apparatus and is frequently associated with symptomatic heart failure and a significant morbidity and mortality. In these patients, left heart pathologies lead to chronic pressure overload of the RV, eventually causing progressive RV dilatation and functional TR. Therefore, TR cannot be considered as isolated heart valve disease pathology but has to be understood and treated as one component of a complex structural RV pathology and is frequently also a marker of an advanced stage of cardiac disease. In these patients, medical therapy restricted to diuretics and heart failure medication is frequently ineffective. Also, severe TR in the setting of advanced heart failure constitutes a high risk for cardiac surgery. Neither one of these treatment options has demonstrated a beneficial effect on long-term prognosis. The recent innovations in transcatheter technology led to efforts to develop interventional approaches to severe TR. Multiple innovative treatment concepts are currently under preclinical and clinical investigation to replace or repair TV function. However, up to date none of these approaches is established and there is still a lack of clinical data to support the efficacy of transcatheter TR treatment. PMID:29892601

Orbiter, Flyby and Lander Mission Concepts for Investigating Europa's Habitability

NASA Astrophysics Data System (ADS)

Prockter, L. M.

2012-04-01

Coauthors: R. T. Pappalardo (1), F. Bagenal (2), A. C. Barr (3), B. G. Bills (1), D. L. Blaney (1), D. D. Blankenship (4), W. Brinckerhoff (5), J. E. P. Connerney (5), K. Hand (1), T. Hoehler (6), W. Kurth (7), M. McGrath (8), M. Mellon (9), J. M. Moore (6), D. A. Senske (1), E. Shock (10), D. E. Smith (11), T. Gavin (1), G. Garner (1), T. Magner (12), B. C. Cooke (1), R. Crum (1), V. Mallder (12), L. Adams (12), K. Klaasen (1), G. W. Patterson (12), and S. D. Vance (1); 1: Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, USA; 2: University of Colorado, Boulder, CO, USA; 3: Brown University, Providence, RI, USA; 4: University of Texas Institute for Geophysics, Austin, TX, USA; 5: NASA Goddard Space Flight Center, Greenbelt, MD, USA; 6: NASA Ames Research Center, Mountain View, CA, USA; 7: University of Iowa, Iowa City, IA, USA; 8: NASA Marshall Space Flight Center, Huntsville, AL, USA; 9: Southwest Research Institute, Boulder, CO, USA; 10: Arizona State University, Tempe, AZ, USA; 11: Massachusetts Institute of Technology, Cambridge, MA, USA; 12: Johns Hopkins University Applied Physics Laboratory, Laurel, MD, USA. Introduction: Assessment of Europa's habitability requires understanding whether the satellite possesses the three "ingredients" for life: water, chemistry, and energy. The National Research Council's Planetary Decadal Survey [1] placed an extremely high priority on Europa science but noted that the budget profile for the Jupiter Europa Orbiter (JEO) mission concept [2] is incompatible with NASA's projected planetary science budget. Thus, in April 2011, NASA enlisted a small Europa Science Definition Team (ESDT) to consider Europa mission options that might be more feasible over the next decade from a programmatic perspective. The ESDT has studied three Europa mission concepts: a Europa orbiter, a Europa multiple-flyby mission, and a Europa lander. These share an overarching goal: Explore Europa to investigate its habitability. Each of the three mission options would address this goal in different and complementary ways, and each has high science value of its own, independent of the others. Each mission concept traces geophysical, compositional, and/or geological investigations that are best addressed by that specific platform. Investigations best addressed through near-continuous global data sets that are obtained under relatively uniform conditions could be undertaken by the orbiter; investigations that are more focused on characterization of local regions could be accomplished by a spacecraft making multiple flybys from Jupiter orbit; and measurements that are most effective from the surface could be addressed by a lander. Although there is overlap in the science objectives of these three mission concepts, each stands alone as a viable Europa mission concept.

Electrical system options for space exploration

NASA Technical Reports Server (NTRS)

Bercaw, Robert W.; Cull, Ronald C.

1991-01-01

The need for a space power utility concept is discussed and the impact of this concept on the engineering of space power systems is examined. Experiences gained from Space Station Freedom and SEI systems studies are used to discuss the factors that may affect the choice of frequency standards on which to build such a space power utility. Emphasis is given to electrical power control, conditioning, and distribution subsystems.

Searching for life with the Terrestrial Planet Finder: Lagrange point options for a formation flying interferometer

NASA Technical Reports Server (NTRS)

Beichman, C.; Gomez, G.; Lo, M.; Masdemont, J.; Romans, L.

2002-01-01

In this paper, we describe the mission design for TPF assuming a distributed spacecraft concept using formation flight around both a halo orbit around L2 as well as a heliocentric orbit. Although the mission architecture is still under study, the next two years will include study of four design cncepts and a downselect to two concepts around 2005.

Reusable Agena study. Volume 1: Executive summary. [space shuttle Agena upper stage tug concept

NASA Technical Reports Server (NTRS)

1974-01-01

The shuttle Agena upper stage interim tug concept is based on a building block approach. These building block concepts are extensions of existing ascent Agena configurations. Several current improvements, have been used in developing the shuttle/Agena upper stage concepts. High-density acid is used as the Agena upper stage oxidizer. The baffled injector is used in the main engine. The DF-224 is a fourth generation computer currently in development and will be flight proven in the near future. The Agena upper stage building block concept uses the current Agena as a baseline, adds an 8.5-inch (21.6 cm) extension to the fuel tank for optimum mixture ratio, uses monomethyl hydrazine as fuel, exchanges a 150:1 nozzle extension for the existing 45:1, exchanges an Autonetics DF-224 for the existing Honeywell computer, and adds a star sensor for guidance update. These modifications to the current Agena provide a 5-foot (1.52m) diameter shuttle/Agena upper stage that will fly all Vandenberg Air Force Base missions in the reusable mode without resorting to a kick motor. The delta V velocity of the Agena is increased by use of a strap-on propellant tank option. This option provides a shuttle/Agena upper stage with the capability to place almost 3900 pounds (1769 kg) into geosynchronous orbit (24 hour period) without the aid of kick motors.

Executive Summary of Ares V: Lunar Capabilities Concept Review Through Phase A-Cycle 3

NASA Technical Reports Server (NTRS)

Holladay, J. B.; Baggett, K. E.; Feldman, S. M.

2011-01-01

This Technical Memorandum (TM) was generated as an overall Ares V summary from the Lunar Capabilities Concept Review (LCCR) through Phase A-Cycle 3 (PA-C3) with the intent that it may be coupled with separately published appendices for a more detailed, integrated narrative. The Ares V has evolved from the initial point of departure (POD) 51.00.48 LCCR configuration to the current candidate POD, PA-C3D, and the family of vehicles concept that contains vehicles PA-C3A through H. The logical progression from concept to POD vehicles is summarized in this TM and captures the trade space and performance of each. The family-of-vehicles concept was assessed during PA-C3 and offered flexibility in the path forward with the ability to add options deemed appropriate. A description of each trade space is given in addition to a summary of each Ares V element. The Ares V contributions to a Mars campaign are also highlighted with the goal of introducing Ares V capabilities within the trade space. The assessment of the Ares V vehicle as it pertains to Mars missions remained locked to the architecture presented in Mars Design Reference Authorization 5.0 using the PA-C3D vehicle configuration to assess Mars transfer vehicle options, in-space EDS capabilities, docking adaptor and propellant transfer assessments, and lunar and Mars synergistic potential.

Restoration of Elbow Flexion.

PubMed

Loeffler, Bryan J; Lewis, Daniel R

2016-08-01

Active elbow flexion is required to position the hand in space, and loss of this function is debilitating. Nerve transfers or nerve grafts to restore elbow flexion may be options when the target muscle is viable, but in delayed reconstruction when the biceps and brachialis are atrophied or damaged, muscle transfer options should be considered. Muscle transfer options are discussed with attention to the advantages and disadvantages of each transfer option. Copyright © 2016 Elsevier Inc. All rights reserved.

The Other Bladder Syndrome: Underactive Bladder

PubMed Central

Miyazato, Minoru; Yoshimura, Naoki; Chancellor, Michael B

2013-01-01

Detrusor underactivity, or underactive bladder (UAB), is defined as a contraction of reduced strength and/or duration resulting in prolonged bladder emptying and/or a failure to achieve complete bladder emptying within a normal time span. UAB can be observed in many neurologic conditions and myogenic failure. Diabetic cystopathy is the most important and inevitable disease developing from UAB, and can occur silently and early in the disease course. Careful neurologic and urodynamic examinations are necessary for the diagnosis of UAB. Proper management is focused on prevention of upper tract damage, avoidance of overdistension, and reduction of residual urine. Scheduled voiding, double voiding, al-blockers, and intermittent self-catheterization are the typical conservative treatment options. Sacral nerve stimulation may be an effective treatment option for UAB. New concepts such as stem cell therapy and neurotrophic gene therapy are being explored. Other new agents for UAB that act on prostaglandin E2 and EP2 receptors are currently under development. The pharmaceutical and biotechnology industries that have a pipeline in urology and women’s health may want to consider UAB as a potential target condition. Scientific counsel and review of the current pharmaceutical portfolio may uncover agents, including those in other therapeutic fields, that may benefit the management of UAB. PMID:23671401

Space-Based Gravitational-wave Mission Concept Studies

NASA Technical Reports Server (NTRS)

Livas, Jeffrey C.

2012-01-01

The LISA Mission Concept has been under study for over two decades as a spacebased gravitational-wave detector capable of observing astrophysical sources in the 0.0001 to 1 Hz band. The concept has consistently received strong recommendations from various review panels based on the expected science, most recently from the US Astr02010 Decadal Review. Budget constraints have led both the US and European Space agencies to search for lower cost options. We report results from the US effort to explore the tradeoffs between mission cost and science return, and in particular a family of mission concepts referred to as SGO (Space-based Gravitational-wave Observatory).

Robotic Lunar Landers for Science and Exploration

NASA Technical Reports Server (NTRS)

Cohen, Barbara A.

2012-01-01

The MSFC/APL Robotic Lunar Landing Project (RLLDP) team has developed lander concepts encompassing a range of mission types and payloads for science, exploration, and technology demonstration missions: (1) Developed experience and expertise in lander systems, (2) incorporated lessons learned from previous efforts to improve the fidelity of mission concepts, analysis tools, and test beds Mature small and medium lander designs concepts have been developed: (1) Share largely a common design architecture. (2) Flexible for a large number of mission and payload options. High risk development areas have been successfully addressed Landers could be selected for a mission with much of the concept formulation phase work already complete

Space-Based Gravitational-Wave Observatory (SGO) Mission Concept Study

NASA Technical Reports Server (NTRS)

Livas, Jeffrey; McNamara, Paul; Jennrich, Oliver

2012-01-01

The LISA Mission Concept has been under study for over two decades as a space-based gravitational-wave detector capable of observing astrophysical sources in the 0.0001 to 1 Hz band. The concept has consistently received strong recommendations from various review panels based on the expected science, most recently from the US Astr02010 Decadal Review. Budget constraints have led both the US and European Space agencies to search for lower cost options. We report results from the US effort to explore the tradeoffs between mission cost and science return.

Low earth orbiting Nadir Etalon Sounding Spectrometer instrument concept for temperature, moisture and trace species, LeoNESS

NASA Technical Reports Server (NTRS)

Kumer, J. B.; Sterritt, L. W.; Roche, A. E.; Rosenberg, W. J.; Morrow, H. E.; Shenk, W. E.; Susskind, J.

1992-01-01

A concept for a low earth orbiting nadir etalon spectrometer sounder (LeoNESS) is described which can achieve retrieval of temperature, H2O, surface, boundary conditions, cloudiness, and trace species with an accuracy that meets or exceeds the AIRS specifications. Options employing 65-K and 30-K detectors are examined; the former may be implemented via passive radiative cooling. The concept, which is derived from the Cryogenic Limb Array Etalon Spectrometer, has the potential for improving the horizontal and vertical resolution.

Job Sharing--A New Way to Work

ERIC Educational Resources Information Center

Olmsted, Barney

1977-01-01

Describes the concept of job sharing, discusses the advantages and disadvantages to employees and employers, examines how widespread the practice is, and suggests ways that interested employers can implement this option. (SH)

Tug fleet and ground operations schedules and controls. Volume 3: Program cost estimates

NASA Technical Reports Server (NTRS)

1975-01-01

Cost data for the tug DDT&E and operations phases are presented. Option 6 is the recommended option selected from seven options considered and was used as the basis for ground processing estimates. Option 6 provides for processing the tug in a factory clean environment in the low bay area of VAB with subsequent cleaning to visibly clean. The basis and results of the trade study to select Option 6 processing plan is included. Cost estimating methodology, a work breakdown structure, and a dictionary of WBS definitions is also provided.

Space station operations task force. Panel 3 report: User development and integration

NASA Technical Reports Server (NTRS)

1987-01-01

The User Development and Integration Panel of the Space Station Operations Task Force was chartered to develop concepts relating to the operations of the Space Station manned base and the platforms, user accommodation and integration activities. The needs of the user community are addressed in the context with the mature operations phase of the Space Station. Issues addressed include space station pricing options, marketing strategies, payload selection and resource allocation options, and manifesting techniques.

Food System Trade Study for a Near-Term Mars Mission

NASA Technical Reports Server (NTRS)

Levri, Julie; Luna, Bernadette (Technical Monitor)

2000-01-01

This paper evaluates several food system options for a near-term Mars mission, based on plans for the 120-day BIO-Plex test. Food systems considered in the study are based on the International Space Station (ISS) Assembly Phase and Assembly Complete food systems. The four systems considered are: 1) ISS assembly phase food system (US portion) with individual packaging without salad production; 2) ISS assembly phase food system (US portion) with individual packaging, with salad production; 3) ISS assembly phase food system (US portion) with bulk packaging, with salad production; 4) ISS assembly complete food system (US portion) with bulk packaging with salad and refrigeration/freezing. The food system options are assessed using equivalent system mass (ESM), which evaluates each option based upon the mass, volume, power, cooling and crewtime requirements that are associated with each food system option. However, since ESM is unable to elucidate the differences in psychological benefits between the food systems, a qualitative evaluation of each option is also presented.

Implementation Options for the PROPEL Electrodynamic Tether Demonstration Mission

NASA Technical Reports Server (NTRS)

Bilen, Sven G.; Johnson, C. Les; Gilchrist, Brian E.; Hoyt, Robert P.; Elder, Craig H.; Fuhrhop, Keith P.; Scadera, Michael; Stone, Nobie

2014-01-01

The PROPEL ("Propulsion using Electrodynamics") flight demonstration mission concept will demonstrate the use of an electrodynamic tether (EDT) for generating thrust, which will allow the propulsion system to overcome the limitations of the rocket equation. The mission concept has been developed by a team of government, industry, and academia partners led by NASA Marshall Space Flight Center (MSFC). PROPEL is being designed for versatility of the EDT system with multiple end users in mind and to be flexible with respect to platform. Previously, we reported on a comprehensive mission design for PROPEL with a mission duration of six months or longer with multiple mission goals including demonstration of significant boost, deboost, inclination change, and drag make-up activities. To explore a range of possible configurations, primarily driven by cost considerations, other mission concept designs have been pursued. In partnership with the NASA's Office of Chief Technologist (OCT) Game Changing Program, NASA MSFC Leadership, and the MSFC Advanced Concepts Office, a mission concept design was developed for a near-term EDT propulsion flight validation mission. The Electrodynamic Tether Propulsion Study (ETPS) defined an EDT propulsion system capable of very large delta-V for use on future missions developed by NASA, DoD, and commercial customers. To demonstrate the feasibility of an ETPS, the study focused on a space demonstration mission concept design with configuration of a pair of tethered satellite busses, one of which is the Japanese H-II Transfer Vehicle (HTV). The HTV would fly its standard ISS resupply mission. When resupply mission is complete, the ISS reconfigures and releases the HTV to perform the EDT experiment at safe orbital altitudes below the ISS. Though the focus of this particular mission concept design addresses a scenario involving the HTV or a similar vehicle, the propulsion system's capability is relevant to a number of applications, as noted above. The ETPS builds on prior work on long-life, failure-resistant, conducting tethers and includes an instrument suite with demonstrated heritage capable of performing necessary diagnostics to measure performance against predictions for a given system size (to be determined) and boost rate. Mission designs in other configurations and launch vehicle options are being developed such that the system can be demonstration should a flight opportunity be identified. We will report on past and ongoing implementation options for PROPEL.

Unlocking Solar for Low- and Moderate-Income Residents: A Matrix of Financing Options by Resident, Provider, and Housing Type

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cook, Jeffrey J.; Bird, Lori A.

Historically the low and moderate income (LMI) market has been underserved by solar photovoltaics (PV), in part due to the unique barriers LMI residents face to participation in the PV market. The intent of this report is to identify the most promising strategies state policymakers might consider to finance PV for LMI customers across three housing types: single family, multi-family, and manufactured housing. The result is a financing matrix that documents the first and second tier financing options states may consider for each housing type. The first tier options were selected based upon their potential impact on LMI PV deployment.more » Second tier financing approaches could also be used to achieve state policy goals, but may not have as much effect on the relevant LMI market segment. Nevertheless, each financing option comes with tradeoffs that state policymakers may wish to consider when they make decisions about which financing approaches are best suited to achieve their LMI PV deployment goals.« less

Space Tug systems study (storable). Volume 3: Executive summary

NASA Technical Reports Server (NTRS)

1974-01-01

Space tug program options that consider key issues and mission requirements are assessed, component and subsystem candidates are evaluated, and tug configurations synthesized. Three tug program options are defined and evaluated.

77 FR 62303 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing and Immediate Effectiveness of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-12

... attendant therewith, may dissuade investors from using SPY options when they can instead use an SPX option... own account or for the account of a customer, must report information, in a manner and form prescribed... surrounding the use of options. The Exchange understands that the Commission, when considering the appropriate...

5 CFR 870.402 - Withholdings for Optional insurance.

Code of Federal Regulations, 2010 CFR

2010-01-01

... individual is considered to reach the next age band the 1st day of the pay period following the pay period in... Withholdings for Optional insurance. (a)(1) The insured individual pays the full cost of all Optional insurance..., it will issue a public notice in the Federal Register. (b) During each pay period in any part of...

26 CFR 1.318-3 - Estates, trusts, and options.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Estates, trusts, and options. 1.318-3 Section 1... (CONTINUED) INCOME TAXES Definitions; Constructive Ownership of Stock § 1.318-3 Estates, trusts, and options... of section 318(a)(2)(B) stock owned by a trust will be considered as being owned by its beneficiaries...

77 FR 64160 - Self-Regulatory Organizations; NYSE Arca, Inc.; Notice of Filing of Proposed Rule Change Relating...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-18

...--PUT--IMP--VOL--50DELTA--DFLT, which is derived from at the money listed put options on each of such... theoretical at-the-money strike. A delta of less than 50 is considered out-of- the-money, while a delta of greater than 50 is considered in-the- money. Each listed put option included in the Index will be an...

Reducing Development and Operations Costs using NASA's "GMSEC" Systems Architecture

NASA Technical Reports Server (NTRS)

Smith, Dan; Bristow, John; Crouse, Patrick

2007-01-01

This viewgraph presentation reviews the role of Goddard Mission Services Evolution Center (GMSEC) in reducing development and operation costs in handling the massive data from NASA missions. The goals of GMSEC systems architecture development are to (1) Simplify integration and development, (2)Facilitate technology infusion over time, (3) Support evolving operational concepts, and (4) All for mix of heritage, COTS and new components. First 3 missions (i.e., Tropical Rainforest Measuring Mission (TRMM), Small Explorer (SMEX) missions - SWAS, TRACE, SAMPEX, and ST5 3-Satellite Constellation System) each selected a different telemetry and command system. These results show that GMSEC's message-bus component-based framework architecture is well proven and provides significant benefits over traditional flight and ground data system designs. The missions benefit through increased set of product options, enhanced automation, lower cost and new mission-enabling operations concept options .

Radioisotope Heater Unit-Based Stirling Power Convertor Development at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Wilson, Scott D.; Geng, Steven M.; Penswick, Lawrence; Schmitz, Paul C.

2017-01-01

Stirling Radioisotope Power Systems (RPS) are being developed as an option to provide power on future space science missions where robotic spacecraft will orbit, flyby, land or rove. A variety of mission concepts have been studied by NASA and the U. S. Department of Energy that would utilize RPS for landers, probes, and rovers and only require milliwatts to tens of watts of power. These missions would contain science measuring instruments that could be distributed across planetary surfaces or near objects of interest in space solar flux insufficient for using solar cells. A low power Stirling convertor is being developed to provide an RPS option for future low power applications. Initial concepts convert heat available from several Radioisotope Heater Units to electrical power for spacecraft instruments and communication. Initial development activity includes defining and evaluating a variety of Stirling configurations and selecting one for detailed design, research of advanced manufacturing methods that could simplify fabrication, evaluating thermal interfaces, characterizing components and subassemblies to validate design codes, and preparing for an upcoming demonstration of proof of concept in a laboratory environment.

Structural Definition and Mass Estimation of Lunar Surface Habitats for the Lunar Architecture Team Phase 2 (LAT-2) Study

NASA Technical Reports Server (NTRS)

Dorsey, John T.; Wu, K, Chauncey; Smith, Russell W.

2008-01-01

The Lunar Architecture Team Phase 2 study defined and assessed architecture options for a Lunar Outpost at the Moon's South Pole. The Habitation Focus Element Team was responsible for developing concepts for all of the Habitats and pressurized logistics modules particular to each of the architectures, and defined the shapes, volumes and internal layouts considering human factors, surface operations and safety requirements, as well as Lander mass and volume constraints. The Structures Subsystem Team developed structural concepts, sizing estimates and mass estimates for the primary Habitat structure. In these studies, the primary structure was decomposed into a more detailed list of components to be sized to gain greater insight into concept mass contributors. Structural mass estimates were developed that captured the effect of major design parameters such as internal pressure load. Analytical and empirical equations were developed for each structural component identified. Over 20 different hard-shell, hybrid expandable and inflatable soft-shell Habitat and pressurized logistics module concepts were sized and compared to assess structural performance and efficiency during the study. Habitats were developed in three categories; Mini Habs that are removed from the Lander and placed on the Lunar surface, Monolithic habitats that remain on the Lander, and Habitats that are part of the Mobile Lander system. Each category of Habitat resulted in structural concepts with advantages and disadvantages. The same modular shell components could be used for the Mini Hab concept, maximizing commonality and minimizing development costs. Larger Habitats had higher volumetric mass efficiency and floor area than smaller Habitats (whose mass was dominated by fixed items such as domes and frames). Hybrid and pure expandable Habitat structures were very mass-efficient, but the structures technology is less mature, and the ability to efficiently package and deploy internal subsystems remains an open issue.

Analytical Modeling of Variable Density Multilayer Insulation for Cryogenic Storage

NASA Technical Reports Server (NTRS)

Hedayat, A.; Hastings, L. J.; Brown, T.; Cruit, Wendy (Technical Monitor)

2001-01-01

A unique foam/Multilayer Insulation (MLI) combination concept for orbital cryogenic storage was experimentally evaluated at NASA Marshall Space Flight Center (MSFC) using the Multipurpose Hydrogen Test Bed (MHTB). The MLI was designed for an on-orbit storage period of 45 days and included several unique features such as: a variable layer density and larger but fewer perforations for venting during ascent to orbit. Test results with liquid hydrogen indicated that the MLI weight or heat leak is reduced by about half in comparison with standard MLI. The focus of this paper is on analytical modeling of the Variable Density MLI (VD-MLI) on-orbit performance (i.e. vacuum/low pressure environment). The foam/VD-MLI combination model is considered to have five segments. The first segment represents the optional foam layer. The second, third, and fourth segments represent three MLI segments with different layer densities. The last segment is considered to be a shroud that surrounds the last MLI layer. Two approaches are considered. In the first approach, the variable density MLI is modeled layer by layer while in the second approach, a semi-empirical model is applied. Both models account for thermal radiation between shields, gas conduction, and solid conduction through the layer separator materials.

Additive Manufacturing: From Form to Function

DTIC Science & Technology

2016-01-01

embedded electronics in clothing that could allow additional protective benefits and health monitoring options.13 AM has also enabled proof-of-concept...the International Space Station (ISS) in September 2014 to test plastics . The second 3D printer was delivered to the ISS in April 2016. In addition...was developed by the Innovative Advanced Concepts program. The sensor is essentially a transparent sheet of plastic with printed elec- tronics that

hCG Triggering in ART: An Evolutionary Concept.

PubMed

Hershko Klement, Anat; Shulman, Adrian

2017-05-17

Human chorionic gonadotropin (hCG) is no longer a single, omnipotent ovulation triggering option. Gonadotropin releasing hormone (GnRH) agonist, initially presented as a substitute for hCG, has led to a new era of administering GnRH agonist followed by hCG triggering. According to this new concept, GnRH agonist enables successful ovum maturation, while hCG supports the luteal phase and pregnancy until placental shift.

Asteroid Redirect Crewed Mission Space Suit and EVA System Architecture Trade Study

NASA Technical Reports Server (NTRS)

Blanco, Raul A.; Bowie, Jonathan T.; Watson, Richard D.; Sipila, Stephanie A.

2014-01-01

The Asteroid Redirect Crewed Mission (ARCM) requires a Launch/Entry/Abort (LEA) suit capability and short duration Extra Vehicular Activity (EVA) capability for Orion. The EVAs will involve a two-person crew for approximately four hours. Currently, two EVAs are planned with one contingency EVA in reserve. Providing this EVA capability is very challenging due to system level constraints and a new and unknown environment. The goal of the EVA architecture for ARCM is one that builds upon previously developed technologies and lessons learned, and that accomplishes the ARCM mission while providing a stepping stone to future missions and destinations. The primary system level constraints are to 1) minimize system mass and volume and 2) minimize the interfacing impacts to the baseline Orion design. In order to minimize the interfacing impacts and to not perturb the baseline Orion schedule, the concept of adding "kits" to the baseline system is proposed. These kits consist of: an EVA kit (converts LEA suit to EVA suit), EVA Servicing and Recharge Kit (provides suit consumables), the EVA Tools, Translation Aids & Sample Container Kit (the tools and mobility aids to complete the tasks), the EVA Communications Kit (interface between the EVA radio and the MPCV), and the Cabin Repress Kit (represses the MPCV between EVAs). This paper will focus on the trade space, analysis, and testing regarding the space suit (pressure garment and life support system). Historical approaches and lessons learned from all past EVA operations were researched. Previous and current, successfully operated EVA hardware and high technology readiness level (TRL) hardware were evaluated, and a trade study was conducted for all possible pressure garment and life support options. Testing and analysis was conducted and a recommended EVA system architecture was proposed. Pressure garment options that were considered for this mission include the currently in-use ISS EVA Mobility Unit (EMU), all variations of the Advanced Crew Escape Suit (ACES), and the Exploration Z-suit. For this mission, the pressure garment that was selected is the Modified ACES (MACES) with EVA enhancements. Life support options that were considered included short closed-loop umbilicals, long open-loop umbilicals, the currently in-use ISS EMU Portable Life Support System (PLSS), and the currently in development Exploration PLSS. For this mission, the life support option that was selected is the Exploration PLSS. The greatest risk in the proposed architecture is viewed to be the comfort and mobility of the baseline MACES and the delicate balance between adding more mobility features while not compromising landing safety. Feasibility testing was accomplished in low fidelity analogs and in the JSC Neutral Buoyancy Laboratory (NBL) to validate the concept before a final recommendation on the architecture was made. The proposed architecture was found to meet the mission constraints, but much more work is required to determine the details of the required suit upgrades, the integration with the PLSS, and the rest of the tools and equipment required to accomplish the mission. This work and further definition of the remaining kits will be conducted in government fiscal year 14.

Modeling of Solid Waste Processing Options in BIO-Plex

NASA Technical Reports Server (NTRS)

Rodriguez, Luis F.; Finn, Cory; Kang, Sukwon; Hogan, John; Luna, Bernadette (Technical Monitor)

2000-01-01

BIO-Plex is a ground-based test bed currently under development by NASA for testing technologies and practices that may be utilized in future long-term life support missions. All aspects of such an Advanced Life Support (ALS) System must be considered to confidently construct a reliable system, which will not only allow the crew to survive in harsh environments, but allow the crew time to perform meaningful research. Effective handling of solid wastes is a critical aspect of the system, especially when recovery of resources contained in the waste is required. This is particularly important for ALS Systems configurations that include a Biomass Production Chamber. In these cases, significant amounts of inedible biomass waste may be produced, which can ultimately serve as a repository of necessary resources for sustaining life, notably carbon, water, and plant nutrients. Numerous biological and physicochemical solid waste processing options have been considered. Biological options include composting, aerobic digestion, and anaerobic digestion. Physicochemical options include pyrolysis, SCWO (supercritical water oxidation), various incineration configurations, microwave incineration, magnetically assisted gasification, and low temperature plasma reaction. Modeling of these options is a necessary step to assist in the design process. A previously developed top-level model of BIO-Plex implemented in MATLAB Simulink (r) for the use of systems analysis and design has been adopted for this analysis. Presently, this model only considered incineration for solid waste processing. Present work, reported here, includes the expansion of this model to include a wider array of solid waste processing options selected from the above options, bearing in mind potential, near term solid waste treatment systems. Furthermore, a trade study has also been performed among these solid waste processing technologies in an effort to determine the ideal technology for long-term life support missions.

Privacy, professionalism and Facebook: a dilemma for young doctors.

PubMed

MacDonald, Joanna; Sohn, Sangsu; Ellis, Pete

2010-08-01

This study aimed to examine the nature and extent of use of the social networking service Facebook by young medical graduates, and their utilisation of privacy options. We carried out a cross-sectional survey of the use of Facebook by recent medical graduates, accessing material potentially available to a wider public. Data were then categorised and analysed. Survey subjects were 338 doctors who had graduated from the University of Otago in 2006 and 2007 and were registered with the Medical Council of New Zealand. Main outcome measures were Facebook membership, utilisation of privacy options, and the nature and extent of the material revealed. A total of 220 (65%) graduates had Facebook accounts; 138 (63%) of these had activated their privacy options, restricting their information to 'Friends'. Of the remaining 82 accounts that were more publicly available, 30 (37%) revealed users' sexual orientation, 13 (16%) revealed their religious views, 35 (43%) indicated their relationship status, 38 (46%) showed photographs of the users drinking alcohol, eight (10%) showed images of the users intoxicated and 37 (45%) showed photographs of the users engaged in healthy behaviours. A total of 54 (66%) members had used their accounts within the last week, indicating active use. Young doctors are active members of Facebook. A quarter of the doctors in our survey sample did not use the privacy options, rendering the information they revealed readily available to a wider public. This information, although it included some healthy behaviours, also revealed personal information that might cause distress to patients or alter the professional boundary between patient and practitioner, as well as information that could bring the profession into disrepute (e.g. belonging to groups like 'Perverts united'). Educators and regulators need to consider how best to advise students and doctors on societal changes in the concepts of what is public and what is private.

The Treatment of Central Sleep Apnea Syndromes in Adults: Practice Parameters with an Evidence-Based Literature Review and Meta-Analyses

PubMed Central

Aurora, R. Nisha; Chowdhuri, Susmita; Ramar, Kannan; Bista, Sabin R.; Casey, Kenneth R.; Lamm, Carin I.; Kristo, David A.; Mallea, Jorge M.; Rowley, James A.; Zak, Rochelle S.; Tracy, Sharon L.

2012-01-01

The International Classification of Sleep Disorders, Second Edition (ICSD-2) distinguishes 5 subtypes of central sleep apnea syndromes (CSAS) in adults. Review of the literature suggests that there are two basic mechanisms that trigger central respiratory events: (1) post-hyperventilation central apnea, which may be triggered by a variety of clinical conditions, and (2) central apnea secondary to hypoventilation, which has been described with opioid use. The preponderance of evidence on the treatment of CSAS supports the use of continuous positive airway pressure (CPAP). Much of the evidence comes from investigations on CSAS related to congestive heart failure (CHF), but other subtypes of CSAS appear to respond to CPAP as well. Limited evidence is available to support alternative therapies in CSAS subtypes. The recommendations for treatment of CSAS are summarized as follows: CPAP therapy targeted to normalize the apnea-hypopnea index (AHI) is indicated for the initial treatment of CSAS related to CHF. (STANDARD)Nocturnal oxygen therapy is indicated for the treatment of CSAS related to CHF. (STANDARD)Adaptive Servo-Ventilation (ASV) targeted to normalize the apnea-hypopnea index (AHI) is indicated for the treatment of CSAS related to CHF. (STANDARD)BPAP therapy in a spontaneous timed (ST) mode targeted to normalize the apnea-hypopnea index (AHI) may be considered for the treatment of CSAS related to CHF only if there is no response to adequate trials of CPAP, ASV, and oxygen therapies. (OPTION)The following therapies have limited supporting evidence but may be considered for the treatment of CSAS related to CHF after optimization of standard medical therapy, if PAP therapy is not tolerated, and if accompanied by close clinical follow-up: acetazolamide and theophylline. (OPTION)Positive airway pressure therapy may be considered for the treatment of primary CSAS. (OPTION)Acetazolamide has limited supporting evidence but may be considered for the treatment of primary CSAS. (OPTION)The use of zolpidem and triazolam may be considered for the treatment of primary CSAS only if the patient does not have underlying risk factors for respiratory depression. (OPTION)The following possible treatment options for CSAS related to end-stage renal disease may be considered: CPAP, supplemental oxygen, bicarbonate buffer use during dialysis, and nocturnal dialysis. (OPTION) Citation: Aurora RN; Chowdhuri S; Ramar K; Bista SR; Casey KR; Lamm CI; Kristo DA; Mallea JM; Rowley JA; Zak RS; Tracy SL. The treatment of central sleep apnea syndromes in adults: practice parameters with an evidence-based literature review and meta-analyses. SLEEP 2012;35(1):17-40. PMID:22215916

Economic Benefits of Improved Water Quality: Public Perceptions of Option and Preservation Values

NASA Astrophysics Data System (ADS)

Bouwes, Nicolaas W., Sr.

The primary objective of this book is to report the authors‧ research approach to the estimation of benefits of water quality improvements in the South Platte River of northeastern Colorado. Benefits included a “consumer surplus” from enhanced enjoyment of water-based recreation, an “option value” of assured choice of future recreation use, and a “preservation value” of the ecosystem and its bequest to future generations. Concepts such as preservation and option value benefits have been often mentioned but seldom estimated in natural resources research. The authors have met their objective by providing the reader with a detailed description of their research without being tedious.

Surgical options for lumbosacral fusion: biomechanical stability, advantage, disadvantage and affecting factors in selecting options.

PubMed

Yoshihara, Hiroyuki

2014-07-01

Numerous surgical procedures and instrumentation techniques for lumbosacral fusion (LSF) have been developed. This is probably because of its high mechanical demand and unique anatomy. Surgical options include anterior column support (ACS) and posterior stabilization procedures. Biomechanical studies have been performed to verify the stability of those options. The options have their own advantage but also disadvantage aspects. This review article reports the surgical options for lumbosacral fusion, their biomechanical stability, advantages/disadvantages, and affecting factors in option selection. Review of literature. LSF has lots of options both for ACS and posterior stabilization procedures. Combination of posterior stabilization procedures is an option. Furthermore, combinations of ACS and posterior stabilization procedures are other options. It is difficult to make a recommendation or treatment algorithm of LSF from the current literature. However, it is important to know all aspects of the options and decision-making of surgical options for LSF needs to be tailored for each patient, considering factors such as biomechanical stress and osteoporosis.

LOX/hydrocarbon auxiliary propulsion system study

NASA Technical Reports Server (NTRS)

Orton, G. F.; Mark, T. D.; Weber, D. D.

1982-01-01

Liquid oxygen/hydrocarbon propulsion systems applicable to a second generation orbiter OMS/RCS were compared, and major system/component options were evaluated. A large number of propellant combinations and system concepts were evaluated. The ground rules were defined in terms of candidate propellants, system/component design options, and design requirements. System and engine component math models were incorporated into existing computer codes for system evaluations. The detailed system evaluations and comparisons were performed to identify the recommended propellant combination and system approach.

A system concept for gradual deployment of geostationary lightsats

NASA Astrophysics Data System (ADS)

Peters, Graham C.; Garry, James R. C.

1993-10-01

Small satellites provide an attractive option for developing countries wishing to own and operate a satellite for the first time. It is proposed that space segment capacity could be built-up in response to increasing traffic requirements by launching small satellites at intervals into a single orbital slot to form a cluster. This paper, which results from an ESA study, reviews the various system aspects which must be considered and develops a suitable approach for multi-satellite deployment and collocation. Particular attention is paid to the system and payload configuration required to achieve effective mutual sparing between the satellites' payloads as the constellation is expanded. Mission and operational aspects are examined to obtain an acceptable risk of collisions between the satellites in a single orbit slot. The complexity and cost of operations are investigated to obtain the optimum size of satellite required to satisfy different demand requirements taken from real market scenarios.

Development of a figure-of-merit for space missions

NASA Technical Reports Server (NTRS)

Preiss, Bruce; Pan, Thomas; Ramohalli, Kumar

1991-01-01

The concept of a quantitative figure-of-merit (FOM) to evaluate different and competing options for space missions is further developed. Over six hundred individual factors are considered. These range from mission orbital mechanics to in-situ resource utilization (ISRU/ISMU) plants. The program utilizes a commercial software package for synthesis and visual display; the details are completely developed in-house. Historical FOM's are derived for successful space missions such as the Surveyor, Voyager, Apollo, etc. A cost FOM is also mentioned. The bulk of this work is devoted to one specific example of Mars Sample Return (MSR). The program is flexible enough to accommodate a variety of evolving technologies. Initial results show that the FOM for sample return is a function of the mass returned to LEO, and that missions utilizing ISRU/ISMU are far more cost effective than those that rely on all earth-transported resources.

Analysis of nuclear waste disposal in space, phase 3. Volume 2: Technical report

NASA Technical Reports Server (NTRS)

Rice, E. E.; Miller, N. E.; Yates, K. R.; Martin, W. E.; Friedlander, A. L.

1980-01-01

The options, reference definitions and/or requirements currently envisioned for the total nuclear waste disposal in space mission are summarized. The waste form evaluation and selection process is documented along with the physical characteristics of the iron nickel-base cermet matrix chosen for disposal of commercial and defense wastes. Safety aspects of radioisotope thermal generators, the general purpose heat source, and the Lewis Research Center concept for space disposal are assessed as well as the on-pad catastrophic accident environments for the uprated space shuttle and the heavy lift launch vehicle. The radionuclides that contribute most to long-term risk of terrestrial disposal were determined and the effects of resuspension of fallout particles from an accidental release of waste material were studied. Health effects are considered. Payload breakup and rescue technology are discussed as well as expected requirements for licensing, supporting research and technology, and safety testing.

Pico Reentry Probes: Affordable Options for Reentry Measurements and Testing

NASA Technical Reports Server (NTRS)

Ailor, William H.; Kapoor, Vinod B.; Allen, Gay A., Jr.; Venkatapathy, Ethiraj; Arnold, James O.; Rasky, Daniel J.

2005-01-01

It is generally very costly to perform in-space and atmospheric entry experiments. This paper presents a new platform - the Pico Reentry Probe (PREP) - that we believe will make targeted flight-tests and planetary atmospheric probe science missions considerably more affordable. Small, lightweight, self-contained, it is designed as a "launch and forget" system, suitable for experiments that require no ongoing communication with the ground. It contains a data recorder, battery, transmitter, and user-customized instrumentation. Data recorded during reentry or space operations is returned at end-of-mission via transmission to Iridium satellites (in the case of earth-based operations) or a similar orbiting communication system for planetary missions. This paper discusses possible applications of this concept for Earth and Martian atmospheric entry science. Two well-known heritage aerodynamic shapes are considered as candidates for PREP: the shape developed for the Planetary Atmospheric Experiment Test (PAET) and that for the Deep Space II Mars Probe.

[Dilemmas and controversies related to cancers of the anterior laryngeal commissure].

PubMed

Djukić, V; Stanković, P; Stevandić, N; Janosević, Lj; Pavlović, B

2004-01-01

From diagnostic and therapeutical aspect, the cancers of the anterior laryngeal commissure are the separate category in glottic cancers. But, they have not been individually classified in the majority of statistical reports, and, therefore, the incidence of the anterior commissural cancer should be taken with precaution. The issue of therapeutical strategy is controversial, considering the options and limitations of resections of the anterior commissural tumors, within the conception of oncological radicalism. Dilemmas are being especially faced with in radiotherapy, given the failures and unsatisfactory radiotherapeutical results. The prospective clinical study included the analysis of the incidence of primary and secondary cancers of the anterior commissure of the larynx. The follow-up of five-year survivals allowed for the establishment of efficiency of the applied therapeutical methods. The results of five-year survival in patients treated by primary surgery were highly more significant in relation to results obtained by radiotherapy of patients.

Analysis of nuclear waste disposal in space, phase 3. Volume 2: Technical report

NASA Astrophysics Data System (ADS)

Rice, E. E.; Miller, N. E.; Yates, K. R.; Martin, W. E.; Friedlander, A. L.

1980-03-01

The options, reference definitions and/or requirements currently envisioned for the total nuclear waste disposal in space mission are summarized. The waste form evaluation and selection process is documented along with the physical characteristics of the iron nickel-base cermet matrix chosen for disposal of commercial and defense wastes. Safety aspects of radioisotope thermal generators, the general purpose heat source, and the Lewis Research Center concept for space disposal are assessed as well as the on-pad catastrophic accident environments for the uprated space shuttle and the heavy lift launch vehicle. The radionuclides that contribute most to long-term risk of terrestrial disposal were determined and the effects of resuspension of fallout particles from an accidental release of waste material were studied. Health effects are considered. Payload breakup and rescue technology are discussed as well as expected requirements for licensing, supporting research and technology, and safety testing.

[Oligometastasized colorectal cancer-modern treatment strategies].

PubMed

Binnebösel, M; Lambertz, A; Dejong, K; Neumann, U P

2018-06-05

The prognosis of colorectal cancer in UICC stage IV has been improved in the last decades by improvements in interdisciplinary treatment. Treatment strategies for oligometastasized colorectal cancer are developing more and more into an individualized treatment. An overview of the current literature of modern treatment concepts in oligometastasized colorectal cancer UICC stage IV is given. Surgery still has the supreme mandate in resectable colorectal liver metastases, as neoadjuvant and adjuvant treatment strategies to not provide any benefits for these patients. In marginal or non-resectable stages systemic treatment is superior in these patients depending on the prognostic parameters. Also in curative settings local treatment options should be considered as a reasonable additive tool. An interesting treatment approach for isolated liver metastases and non-resectable colorectal cancer is liver transplantation. Irrespective of new developments in treatment strategies for metastasized colorectal cancer, resection of colorectal liver metastases remains the gold standard whenever possible.

A new blood pump for cardiopulmonary bypass: the HiFlow centrifugal pump.

PubMed

Göbel, C; Eilers, R; Reul, H; Schwindke, P; Jörger, M; Rau, G

1997-07-01

Centrifugal blood pumps are considered to be generally superior to the traditionally used roller pumps in cardiopulmonary bypass. In our institute a new lightweight centrifugal sealless blood pump with a unique spherical thrust bearing and with a magnetic coupling was developed, the HiFlow. The small design makes the pump suitable for applications in complex devices or close to a patient. Hemolysis tests were carried out in which the BioMedicus pump BP-80 and a roller pump were used as reference. The centrifugal pump HiFlow showed the least blood trauma within the group of investigated pumps. In summary, the HiFlow pump concept with its low priming volume and limited contact surfaces shows great potential for clinical applications in cardiopulmonary bypass. Also, the possibility of using the pump as a short-term assist device with an option of a pulsatile driving mode was demonstrated.

Evaluation of new Deflux administration techniques: intraureteric HIT and Double HIT for the endoscopic correction of vesicoureteral reflux.

PubMed

Kirsch, Andrew J; Arlen, Angela M

2014-09-01

Vesicoureteral reflux (VUR) is one of the most common urologic diagnoses affecting children, and optimal treatment requires an individualized approach that considers potential risks. Management options include observation with or without continuous antibiotic prophylaxis and surgical correction via endoscopic, open or laparoscopic/robotic approaches. Endoscopic correction of VUR is an outpatient procedure associated with decreased morbidity compared with ureteral reimplantation. The concept of ureteral hydrodistention and intraluminal submucosal injection (Hydrodistention Implantation Technique [HIT]) has led to improved success rates in eliminating VUR compared with the subureteral transurethral injection technique. Further modifications now include use of proximal and distal intraluminal injections (Double HIT) that result in coaptation of both the ureteral tunnel and orifice. Endoscopic injection of dextranomer/hyaluronic acid copolymer, via the HIT and Double HIT, has emerged as a highly successful, minimally invasive alternative to open surgical correction, with minimal associated morbidity.

Breaking Binaries? Biomedicine and Serostatus Borderlands among Couples with Mixed HIV Status.

PubMed

Persson, Asha; Newman, Christy E; Ellard, Jeanne

2017-01-01

With recent breakthroughs in HIV treatment and prevention, the meanings of HIV-positivity and HIV-negativity are changing at biomedical and community levels. We explore how binary constructions of HIV serostatus identities are giving way to something more complex that brings both welcome possibilities and potential concerns. We draw on research with couples with mixed HIV status to argue that, in the context of lived experiences, serostatus identities have always been more ambiguous than allowed for in HIV discourse. However, their supposed dichotomous quality seems even more dubious now in view of contemporary biomedical technologies. Invoking the anthropological concept of "borderlands," we consider how biomedicine is generating more diverse serostatus identities, widening the options for how to live with HIV, and eroding the stigmatizing serostatus binary that has haunted the epidemic. But we also ask whether this emerging borderland, and its "normalizing" tendencies, is concomitantly giving rise to new and troubling binaries.

The Advanced Gamma-ray Imaging System (AGIS): Telescope Optical System Designs

NASA Astrophysics Data System (ADS)

Hanna, David S.; Buckley, J. H.; Falcone, A.; Fegan, S.; Finley, J.; Guarino, V.; Kaaret, P.; Krawczynski, H.; Krennrich, F.; Konopelko, A.; Romani, R.; Vassilliev, V.; Optical System Working Group; AGIS Collaboration

2008-03-01

The concept of a future ground-based gamma-ray observatory, AGIS, in the energy range 20 GeV-200 TeV is based on an array of 50-200 imaging atmospheric Cherenkov telescopes (IACTs). The anticipated improvement of AGIS sensitivity, angular resolution, and reliability of operation imposes demanding technological and cost requirements on the design of IACTs. In this submission we will focus on the optical system (OS) of AGIS telescopes and consider options which include traditional Davies-Cotton and the other prime-focus telescope designs, as well as the novel two-mirror aplanatic OS originally proposed by Schwarzschild. The emerging new mirror production technologies based on replication processes, such as cold and hot glass slumping, cured CFRP, and electroforming, provide new opportunities for cost effective solutions for the design of the OS. We initially evaluate capabilities of these mirror fabrication methods for the AGIS project.

Sodium Based Heat Pipe Modules for Space Reactor Concepts: Stainless Steel SAFE-100 Core

NASA Technical Reports Server (NTRS)

Martin, James J.; Reid, Robert S.

2004-01-01

A heat pipe cooled reactor is one of several candidate reactor cores being considered for advanced space power and propulsion systems to support future space exploration applications. Long life heat pipe modules, with designs verified through a combination of theoretical analysis and experimental lifetime evaluations, would be necessary to establish the viability of any of these candidates, including the heat pipe reactor option. A hardware-based program was initiated to establish the infrastructure necessary to build heat pipe modules. This effort, initiated by Los Alamos National Laboratory and referred to as the Safe Affordable Fission Engine (SAFE) project, set out to fabricate and perform non-nuclear testing on a modular heat pipe reactor prototype that can provide 100 kilowatt from the core to an energy conversion system at 700 C. Prototypic heat pipe hardware was designed, fabricated, filled, closed-out and acceptance tested.

Consumer perception of dry-cured sheep meat products: Influence of process parameters under different evoked contexts.

PubMed

de Andrade, Juliana Cunha; Nalério, Elen Silveira; Giongo, Citieli; de Barcellos, Marcia Dutra; Ares, Gastón; Deliza, Rosires

2017-08-01

The development of high-quality air-dried cured sheep meat products adapted to meet consumer demands represent an interesting option to add value to the meat of adult animals. The present study aimed to evaluate the influence of process parameters on consumer choice of two products from sheep meat under different evoked contexts, considering product concepts. A total of 375 Brazilian participants completed a choice-based conjoint task with three 2-level variables for each product: maturation time, smoking, and sodium reduction for dry-cured sheep ham, and natural antioxidant, smoking, and sodium reduction for sheep meat coppa. A between-subjects experimental design was used to evaluate the influence of consumption context on consumer choices. All the process parameters significantly influenced consumer choice. However, their relative importance was affected by evoked context. Copyright © 2017. Published by Elsevier Ltd.

Mechanisms, determination and the metaphysics of neuroscience.

PubMed

Soom, Patrice

2012-09-01

In this paper, I evaluate recently defended mechanistic accounts of the unity of neuroscience from a metaphysical point of view. Considering the mechanistic framework in general (Sections 2 and 3), I argue that explanations of this kind are essentially reductive (Section 4). The reductive character of mechanistic explanations provides a sufficiency criterion, according to which the mechanism underlying a certain phenomenon is sufficient for the latter. Thus, the concept of supervenience can be used in order to describe the relation between mechanisms and phenomena (Section 5). Against this background, I show that the mechanistic framework is subject to the causal exclusion problem and faces the classical metaphysical options when it comes to the relations obtaining between different levels of mechanisms (Section 6). Finally, an attempt to improve the metaphysics of mechanisms is made (Section 7) and further difficulties are pointed out (Section 8). Copyright © 2012 Elsevier Ltd. All rights reserved.

Waste Handling and Emplacement Options for Disposal of Radioactive Waste in Deep Boreholes.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cochran, John R.; Hardin, Ernest

2015-11-01

Traditional methods cannot be used to handle and emplace radioactive wastes in boreholes up to 16,400 feet (5 km) deep for disposal. This paper describes three systems that can be used for handling and emplacing waste packages in deep borehole: (1) a 2011 reference design that is based on a previous study by Woodward–Clyde in 1983 in which waste packages are assembled into “strings” and lowered using drill pipe; (2) an updated version of the 2011 reference design; and (3) a new concept in which individual waste packages would be lowered to depth using a wireline. Emplacement on coiled tubingmore » was also considered, but not developed in detail. The systems described here are currently designed for U.S. Department of Energy-owned high-level waste (HLW) including the Cesium- 137/Strontium-90 capsules from the Hanford Facility and bulk granular HLW from fuel processing in Idaho.« less

Ethical considerations in neonatal respiratory care.

PubMed

Orzalesi, Marcello; Cuttini, Marina

2005-01-01

Recent advances in neonatal care have greatly improved the chances for survival of very sick and/or very preterm neonates and have in fact changed the concept and the limits of viability. However, in some situations, when the infant's demise can only be postponed at the price of great suffering or when survival is associated with severe disabilities and an intolerable life for the patient and the parents, it may be unwise to employ the full armamentarium of modern neonatal intensive care. In those circumstances withholding or withdrawing mechanical ventilation and other life-saving, though invasive and painful, procedures might be a better option. This review examines the ethical principles underlying those difficult decisions, the most frequent circumstances where they should be considered, the role of parents and other parties in the decision-making process and the reported behavior of neonatologists in many American and European neonatal intensive care units. Copyright 2005 S. Karger AG, Basel

An assessment of inductive coupling roadway powered vehicles

NASA Technical Reports Server (NTRS)

Leschly, K. O.; Feinberg, A.; Heft, R.; Warren, G.

1980-01-01

The technical concept underlying the roadway powered vehicle system is the combination of an electrical power source embedded in the roadway and a vehicle-mounted power pickup that is inductively coupled to the roadway power source. The feasibility of such a system, implemented on a large scale was investigated. Factors considered included current and potential transportation modes and requirements, economics, energy, technology, social and institutional issues. These factors interrelate in highly complex ways, and a firm understanding of each of them does not yet exist. The study therefore was structured to manipulate known data in equally complex ways to produce a schema of options and useful questions that can form a basis for further, harder research. A dialectical inquiry technique was used in which two adversary teams, mediated by a third-party team, debated each factor and its interrelationship with the whole of the known information on the topic.

Large space-based systems for dealing with global environment change

NASA Technical Reports Server (NTRS)

Jenkins, Lyle M.

1992-01-01

Increased concern over the effects of global climate change and depletion of the ozone layer has resulted in support for the Global Change Research Program and the Mission to Planet Earth. Research to understand Earth system processes is critical, but it falls short of providing ways of mitigating the effects of change. Geoengineering options and alternatives to interactively manage change need to be developed. Space-based concepts for dealing with changes to the environment should be considered in addition to Earth-based actions. 'Mission for Planet Earth' describes those space-based geoengineering solutions that may combine with an international global change program to stabilize the Global environment. Large space systems that may be needed for this response challenge guidance and control engineering and technology. Definition, analysis, demonstration, and preparation of geoengineering technology will provide a basis for policy response if global change consequences are severe.

Power Requirements for The NASA Mars Design Reference Architecture (DRA) 5.0

NASA Technical Reports Server (NTRS)

Cataldo, Robert L.

2009-01-01

This paper summarizes the power systems analysis results from NASA s recent Mars DRA 5.0 study which examined three architecture options and resulting mission requirements for a human Mars landing mission in the post-2030 timeframe. DRA 5.0 features a long approximately 500 day surface stay split mission using separate cargo and crewed Mars transfer vehicles. Two cargo flights, utilizing minimum energy trajectories, pre-deploy a cargo lander to the surface and a habitat lander into a 24-hour elliptical Mars parking orbit where it remains until the arrival of the crew during the next mission opportunity approximately 26 months later. The pre-deployment of cargo poses unique challenges for set-up and emplacement of surface assets that results in the need for self or robotically deployed designs. Three surface architecture options were evaluated for breadth of science content, extent of exploration range/capability and variations in system concepts and technology. This paper describes the power requirements for the surface operations of the three mission options, power system analyses including discussion of the nuclear fission, solar photovoltaic and radioisotope concepts for main base power and long range mobility.

Assessment of Silicon Carbide Composites for Advanced Salt-Cooled Reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Katoh, Yutai; Wilson, Dane F; Forsberg, Charles W

2007-09-01

The Advanced High-Temperature Reactor (AHTR) is a new reactor concept that uses a liquid fluoride salt coolant and a solid high-temperature fuel. Several alternative fuel types are being considered for this reactor. One set of fuel options is the use of pin-type fuel assemblies with silicon carbide (SiC) cladding. This report provides (1) an initial viability assessment of using SiC as fuel cladding and other in-core components of the AHTR, (2) the current status of SiC technology, and (3) recommendations on the path forward. Based on the analysis of requirements, continuous SiC fiber-reinforced, chemically vapor-infiltrated SiC matrix (CVI SiC/SiC) compositesmore » are recommended as the primary option for further study on AHTR fuel cladding among various industrially available forms of SiC. Critical feasibility issues for the SiC-based AHTR fuel cladding are identified to be (1) corrosion of SiC in the candidate liquid salts, (2) high dose neutron radiation effects, (3) static fatigue failure of SiC/SiC, (4) long-term radiation effects including irradiation creep and radiation-enhanced static fatigue, and (5) fabrication technology of hermetic wall and sealing end caps. Considering the results of the issues analysis and the prospects of ongoing SiC research and development in other nuclear programs, recommendations on the path forward is provided in the order or priority as: (1) thermodynamic analysis and experimental examination of SiC corrosion in the candidate liquid salts, (2) assessment of long-term mechanical integrity issues using prototypical component sections, and (3) assessment of high dose radiation effects relevant to the anticipated operating condition.« less

Satellite Power Systems (SPS) Concept Definition Study. Volume 1: Executive Summary

NASA Technical Reports Server (NTRS)

Hanley, G.

1978-01-01

The evolution of a total satellite power is described as well as major subsystem alternatives. Trade study results are given for satellite concepts, ground receiving antennas, satellite construction sites, and transportation. Point design definition, end-to-end analysis, and programmatics are covered. The GaAlAs photovoltaic concept is recommended as the current preliminary baseline satellite concept with silicon photovoltaic and Rankine cycle solar-thermal concepts as viable alternatives. Geosynchronous orbit is preferred for the construction of the satellite. A horizontal takeoff and landing air breathing rocket HLLV concept is preferred for earth-to-LEO transportation, with vertical takeoff options as viable alternatives. An argon electric orbit transfer vehicle is preferred for cargo transport from LEO and GEO orbit, and a chemical LH2/L02, two-stage orbit transfer vehicle is recommended for crew transport. A stripline rectenna array is the current preferred concept.

Design Options for the High-Foot Ignition Capsule Series on NIF

NASA Astrophysics Data System (ADS)

Dittrich, T. R.; Hurricane, O. A.; Berzak Hopkins, L. F.; Callahan, D. A.; Clark, D.; Doeppner, T.; Haan, S. W.; Hammel, B. A.; Harte, J. A.; Hinkel, D. E.; Ma, T.; Pak, A. E.; Park, H.-S.; Salmonson, J. D.; Weber, C. R.; Zimmerman, G. B.; Olson, R. E.; Kline, J. L.; Leeper, R. J.

2015-11-01

Several options exist for improving implosion performance in the High-Foot series of ignition capsules on NIF. One option is to modify the fill tube used to supply DT to the capsule. Simulations indicate that a gold-coated glass tube may reduce implosion hydro effects and allow fielding a larger diameter tube capable of supporting the capsule, eliminating the need for the nominal tent support. A second option adds a fourth shock to the implosion history. According to simulation, this extra shock improves fuel confinement and capsule performance. A third option studies the feasibility of holding the DT fuel in liquid form in a foam layer inside the shell. This ``wetted foam'' concept, advanced by Olson, has existed for several years and may allow some control over the convergence of the capsule during implosion. This work was performed under the auspices of the Department of Energy by Lawrence Livermore National Laboratory under contract DE-AC52-07NA27344.

Real-life decision making in college students. I: Consistency across specific decisions.

PubMed

Galotti, Kathleen M; Wiener, Hillary J D; Tandler, Jane M

2014-01-01

First-year undergraduates participated in a short-term longitudinal study of real-life decision making over their first 14 months of college. They were surveyed about 7 different decisions: choosing courses for an upcoming term (3 different terms), choosing an academic major (twice), planning for the upcoming summer, and planning for sophomore-year housing. Participants showed moderate levels of consistency in the options they considered and in the criteria they used to decide between options, with about half of the options or criteria being used at 2 different points on the decision repeatedly studied. Participants varied somewhat in structural consistency, the tendency to consider the same number of options or criteria across decisions. They also varied in the way they integrated information across decision-making tasks. We suggest that people attempt to keep the information demands of the task within workable limits, sometimes sacrificing consistency as a result.

Assessing Option Grid® practicability and feasibility for facilitating shared decision making: An exploratory study.

PubMed

Tsulukidze, Maka; Grande, Stuart W; Gionfriddo, Michael R

2015-07-01

To assess the feasibility of Option Grids(®)for facilitating shared decision making (SDM) in simulated clinical consultations and explore clinicians' views on their practicability. We used mixed methods approach to analyze clinical consultations using the Observer OPTION instrument and thematic analysis for follow-up interviews with clinicians. Clinicians achieved high scores on information sharing and low scores on preference elicitation and integration. Four themes were identified: (1) Barriers affect practicability of Option Grids(®); (2) Option Grids(®) facilitate the SDM process; (3) Clinicians are aware of the gaps in their practice of SDM; (4) Training and ongoing feedback on the optimal use of Option Grids(®) are necessary. Use of Option Grids(®) by clinicians with background knowledge in SDM did not facilitate optimal levels of competency on the SDM core concepts of preference elicitation and integration. Future research must evaluate the impact of training on the use of Option Grids(®), and explore how best to help clinicians bridge the gap between knowledge and action. Clinicians proficiently imparting information in simulations struggled to elicit and integrate patient preferences - understanding this gap and developing strategies to close it are the next steps for implementing SDM into clinical practice. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Fragmentation targeted at preferred discontinuities: A new concept in endolithotripsy with Holmium laser:YAG.

PubMed

Sánchez-Martín, F M; Emiliani, E; Pueyo-Morer, E; Angerri-Feu, O; Sanguedolce, F; Millán, F; Villavicencio, H

2018-04-17

There are currently 3holmium laser, YAG (Ho:YAG) endolithotripsy procedures that are considered basic (fragmentation, pulverisation, "pop-corn" technique). We present the technique of fragmentation targeted at preferred discontinuities (FTPD), a new concept of endolithotripsy by Ho:YAG laser. The FTPD technique is based on the selective application of energy (targeting a specific preselected point) to an area that is visually prone to the formation of a fracture line or preferred discontinuity (conditioned by the anisotropy of the urolithiasis). The ideal energy regimen (setting) is a high range of working energy (2-3J) with a very low frequency range (5-8Hz) and short pulse width. Between January 2015 to February 2017, the FTPD technique was used in 37 procedures (7 NLP, 16 RIRS, 12 URS, 2 cystolithotomies), with a Ho:YAG laser (Lumenis Pulse 120H ® , Tel-Aviv, Israel). Maximum power used: 24W (3J/8Hz) with fibres of 365μ and 273μ (URS, RIRS), and 32W (4J/8Hz) with fibres of 550μ (NLP, cystolithotomy). Strategic improvement was achieved in all cases using the TFPD technique to continue the endolithotripsy or remove fragments. No complications were recorded after the use of this method. FTPD can be considered a complementary option in combination with the basic methods of fragmentation and pulverisation. In our experience, it constitutes significant progress in optimising the performance of Ho:YAG laser endolithotripsy. Copyright © 2018 AEU. Publicado por Elsevier España, S.L.U. All rights reserved.

Training cognition in ADHD: current findings, borrowed concepts, and future directions.

PubMed

Rutledge, Kyle J; van den Bos, Wouter; McClure, Samuel M; Schweitzer, Julie B

2012-07-01

With both its high prevalence and myriad of negative outcomes, Attention-Deficit/Hyperactivity Disorder (ADHD) demands a careful consideration of the efficacy of its treatment options. Although the benefits of medication have a robust empirical background, nonpharmaceutical interventions evoke particular interest, as they are often viewed more favorably by parents. This review pays special attention to the use of working memory and recent cognitive training attempts in ADHD, describing its cognitive, behavioral, and biological effects in relation to current neurological theory of the disorder. While these treatments have demonstrated positive effects on some measures, there are limitations, as studies have failed to demonstrate generalization to critical measures, such as teacher-rated classroom behaviors, and have provided limited but growing evidence of functionally significant improvements in behavior. There is also a clear lack of research on the effects of training on reward systems and self-control. These limitations may be addressed by broadening the scope and procedures of the training and incorporating research concepts from other fields of study. First, it is important to consider the developmental trajectories of brain regions in individuals with the disorder, as they may relate to the effectiveness of cognitive training. Notions from behavioral economics, including delay discounting and framing (i.e., context) manipulations that influence present orientation, also have applications in the study of cognitive training in ADHD. In considering these other domains, we may find new ways to conceptualize and enhance cognitive training in ADHD and, in turn, address current limitations of interventions that fall in this category.

Should health care professionals encourage living kidney donation?

PubMed

Hilhorst, Medard T; Kranenburg, Leonieke W; Busschbach, Jan J V

2007-03-01

Living kidney donation provides a promising opportunity in situations where the scarcity of cadaveric kidneys is widely acknowledged. While many patients and their relatives are willing to accept its benefits, others are concerned about living kidney programs; they appear to feel pressured into accepting living kidney transplantations as the only proper option for them. As we studied the attitudes and views of patients and their relatives, we considered just how actively health care professionals should encourage living donation. We argue that active interference in peoples' personal lives is justified - if not obligatory. First, we address the ambiguous ideals of non-directivity and value neutrality in counselling. We describe the main pitfalls implied in these concepts, and conclude that these concepts cannot account for the complex reality of living donation and transplantation. We depict what is required instead as truthful information and context-relative counselling. We then consider professional interference into personal belief systems. We argue that individual convictions are not necessarily strong, stable, or deep. They may be flawed in many ways. In order to justify interference in peoples' personal lives, it is crucial to understand the structure of these convictions. Evidence suggests that both patients and their relatives have attitudes towards living kidney donation that are often open to change and, accordingly, can be influenced. We show how ethical theories can account for this reality and can help us to discern between justified and unjustified interference. We refer to Stephen Toulmin's model of the structure of logical argument, the Rawlsian model of reflective equilibrium, and Thomas Nagel's representation of the particularistic position.

Large Deployable Reflector Technologies for Future European Telecom and Earth Observation Missions

NASA Astrophysics Data System (ADS)

Ihle, A.; Breunig, E.; Dadashvili, L.; Migliorelli, M.; Scialino, L.; van't Klosters, K.; Santiago-Prowald, J.

2012-07-01

This paper presents requirements, analysis and design results for European large deployable reflectors (LDR) for space applications. For telecommunications, the foreseeable use of large reflectors is associated to the continuous demand for improved performance of mobile services. On the other hand, several earth observation (EO) missions can be identified carrying either active or passive remote sensing instruments (or both), in which a large effective aperture is needed e.g. BIOMASS. From the European point of view there is a total dependence of USA industry as such LDRs are not available from European suppliers. The RESTEO study is part of a number of ESA led activities to facilitate European LDR development. This paper is focused on the structural-mechanical aspects of this study. We identify the general requirements for LDRs with special emphasis on launcher accommodation for EO mission. In the next step, optimal concepts for the LDR structure and the RF-Surface are reviewed. Regarding the RF surface, both, a knitted metal mesh and a shell membrane based on carbon fibre reinforced silicon (CFRS) are considered. In terms of the backing structure, the peripheral ring concept is identified as most promising and a large number of options for the deployment kinematics are discussed. Of those, pantographic kinematics and a conical peripheral ring are selected. A preliminary design for these two most promising LDR concepts is performed which includes static, modal and kinematic simulation and also techniques to generate the reflector nets.

Lunar Navigation with Libration Point Orbiters and GPS

NASA Technical Reports Server (NTRS)

Carpenter, J. Russell

2004-01-01

NASA is currently studying a Vision for Space Exploration based on spiral development of robotic and piloted missions to the moon and Mars, but research into how to perform such missions has continued ever since the first era of lunar exploration. One area of study that a number of researchers have pursued is libration point navigation and communication relay concepts. These concepts would appear to support many of NASA's current requirements for navigation and communications coverage for human and robotic spacecraft operating in lunar space and beyond. In trading libration point concepts against other options, designers must consider issues such as the number of spacecraft, required to provide coverage, insertion and stationkeeping costs, power and data rate requirements, frequency allocations, and many others. The libration points, along with a typical cis-lunar trajectory, are equilibrium locations for an infinitesimal mass in the rotating coordinate system that follows the motion of two massive bodies in circular orbits with respect to their common barycenter. There are three co-linear points along the line connecting the massive bodies: between the bodies, beyond the secondary body, and beyond the primary body. The relative distances of these points along the line connecting the bodies depend on the mass ratios. There are also two points that form equilateral triangles with the massive bodies. Ideally, motion in the neighborhood of the co-linear points is unstable, while motion near the equilibrium points is stable. However, in the real world, the motions are highly perturbed so that a satellite will require stationkeeping maneuvers.

Highly Reusable Space Transportation (HRST) Baseline Concepts and Analysis: Rocket/RBCC Options. Part 2; A Comparative Study

NASA Technical Reports Server (NTRS)

Woodcock, Gordon

1997-01-01

This study is an extension of a previous effort by the Principal Investigator to develop baseline data to support comparative analysis of Highly Reusable Space Transportation (HRST) concepts. The analyses presented herin develop baseline data bases for two two-stage-to-orbit (TSTO) concepts: (1) Assisted horizontal take-off all rocket (assisted HTOHL); and (2) Assisted vertical take-off rocket based combined cycle (RBCC). The study objectives were to: (1) Provide configuration definitions and illustrations for assisted HTOHL and assisted RBCC; (2) Develop a rationalization approach and compare these concepts with the HRST reference; and (3) Analyze TSTO configurations which try to maintain SSTO benefits while reducing inert weight sensitivity.

Lunar Transportation Facilities and Operations Study, option 1

NASA Astrophysics Data System (ADS)

1991-05-01

Throughout the Option I period of the Lunar Transportation Facilities and Operations Study (LTFOS), McDonnell Douglas Space Systems Company - Kennedy Space Center (MDSSC-KSC) provided support to both the Planetary Surface Systems (PSS) Office at the National Aeronautics and Space Administration (NASA) at the Johnson Space Center and to the Flight and Ground Systems Projects Office (Payload Projects Management) at the Kennedy Space Center. The primary objective of the Option I phase of the study was to assist the above NASA centers in developing Space Exploration Initiative (SEI) concepts. MDSSC-KSC conducted three analyses which provided launch and landing detail to the proposed exploration concepts. One analysis, the Lunar Ejecta Assessment, was conducted to determine the effects of launch and landing a vehicle in a dusty environment. A second analysis, the Thermal/Micrometeoroid Protection Trade Study, was refined to determine the impacts that Reference Architecture Option 5A would have on thermal/micrometeoroid protection approaches. The third analysis, the Centaur Prelaunch Procedure Analysis, used a Centaur prelaunch test and checkout flow to identify key considerations that would be important if a Lunar Excursion Vehicle (LEV) was to use an expander cycle liquid oxygen-liquid hydrogen engine. Several 'quick look' assessments were also conducted. One quick look assessment, the Storable Propellant Quick Look Assessment, was conducted to identify design considerations that should be made if storable propellants were to be used instead of liquid oxygen and liquid hydrogen. The LEV Servicer Maintenance Analysis provided an early look at the effort required to maintain an LEV Servicer on the lunar surface. Also, support was provided to the PSS Logistics Manager to develop initial LEV Servicer cost inputs. Consideration was given to the advanced development that must be provided to accomplish a lunar and/or Mars mission. MDSS-KSC also provided support to both MASE and PSS by reviewing and commenting on architecture documents and concept definitions to ensure adequate considerations were given to the launch and landing function of an exploration initiative.

Lunar Transportation Facilities and Operations Study, option 1

NASA Technical Reports Server (NTRS)

1991-01-01

Throughout the Option I period of the Lunar Transportation Facilities and Operations Study (LTFOS), McDonnell Douglas Space Systems Company - Kennedy Space Center (MDSSC-KSC) provided support to both the Planetary Surface Systems (PSS) Office at the National Aeronautics and Space Administration (NASA) at the Johnson Space Center and to the Flight and Ground Systems Projects Office (Payload Projects Management) at the Kennedy Space Center. The primary objective of the Option I phase of the study was to assist the above NASA centers in developing Space Exploration Initiative (SEI) concepts. MDSSC-KSC conducted three analyses which provided launch and landing detail to the proposed exploration concepts. One analysis, the Lunar Ejecta Assessment, was conducted to determine the effects of launch and landing a vehicle in a dusty environment. A second analysis, the Thermal/Micrometeoroid Protection Trade Study, was refined to determine the impacts that Reference Architecture Option 5A would have on thermal/micrometeoroid protection approaches. The third analysis, the Centaur Prelaunch Procedure Analysis, used a Centaur prelaunch test and checkout flow to identify key considerations that would be important if a Lunar Excursion Vehicle (LEV) was to use an expander cycle liquid oxygen-liquid hydrogen engine. Several 'quick look' assessments were also conducted. One quick look assessment, the Storable Propellant Quick Look Assessment, was conducted to identify design considerations that should be made if storable propellants were to be used instead of liquid oxygen and liquid hydrogen. The LEV Servicer Maintenance Analysis provided an early look at the effort required to maintain an LEV Servicer on the lunar surface. Also, support was provided to the PSS Logistics Manager to develop initial LEV Servicer cost inputs. Consideration was given to the advanced development that must be provided to accomplish a lunar and/or Mars mission. MDSS-KSC also provided support to both MASE and PSS by reviewing and commenting on architecture documents and concept definitions to ensure adequate considerations were given to the launch and landing function of an exploration initiative.

Strategic Implications of U.S. Troop Drawdown in Europe

DTIC Science & Technology

2012-03-15

day operations. This concept also opens other alternative options such as the “ lily padding ” or “leap frogging” of units. This means that the...bases can quickly become operational to support rotational Brigade Combat Teams (BCT), Air Wings and critical lift requirements. Initially, the lily ... pad concept “was advocated by former Defense Secretary Donald Rumsfeld, where you fly in, you land like a frog, and you hop on to your next

Solar thermal conversion

NASA Technical Reports Server (NTRS)

Selcuk, M. K.

1978-01-01

A brief review of the fundamentals of the conversion of solar energy into mechanical work (or electricity via generators) is given. Both past and present work on several conversion concepts are discussed. Solar collectors, storage systems, energy transport, and various types of engines are examined. Ongoing work on novel concepts of collectors, energy storage and thermal energy conversion are outlined and projections for the future are described. Energy costs for various options are predicted and margins and limitations are discussed.

Service contract with periodic preventive maintenance for a dump truck sold with a two-dimensional warranty

NASA Astrophysics Data System (ADS)

Nasrum, A.; Pasaribu, U. S.; Husniah, H.

2016-02-01

This paper deals with maintenance service contract for a dump truck sold with a two-dimensional warranties. We consider a situation where an agent offers two maintenance contract options and the owner of the equipment has to select the optimal option either the OEM carried out all repairs and preventive maintenance activities (option one) or the OEM only carries out failure while the costumer undertakes preventive maintenance action in-house (option two). As the number of preventive maintenance and corrective maintenance that occurs in the area of servicing contracts is very influential in determining the value of the contract, we have to determine the optimal time between preventive maintenance that can minimize the cost of repair in the contract area. Moreover, we also study the maintenance service contract considering reduction of the intensity function after preventive maintenance from both the owner and OEM point of views. In this paper, we use a Weibull intensity function to consider a product with increasing failure intensity. We use a non-cooperative game formulation to determine the optimal price structure (i.e., the contract price and repair cost) for the OEM and the owner. A numerical example derived from the model has shown that if the owner choose option one then the owner obtain a higher profit compared with the profit resulted from option two. The result agree with earlier work which uses the accelerated failure time (AFT) for the failure modeling, while here we model the failure of the dump truck without the use of the AFT.

Preeradication vaccine policy options for poliovirus infection and disease control.

PubMed

Thompson, Kimberly M; Pallansch, Mark A; Duintjer Tebbens, Radboud J; Wassilak, Steve G; Kim, Jong-Hoon; Cochi, Stephen L

2013-04-01

With the circulation of wild poliovirus (WPV) types 1 and 3 continuing more than a decade after the original goal of eradicating all three types of WPVs by 2000, policymakers consider many immunization options as they strive to stop transmission in the remaining endemic and outbreak areas and prevent reintroductions of live polioviruses into nonendemic areas. While polio vaccination choices may appear simple, our analysis of current options shows remarkable complexity. We offer important context for current and future polio vaccine decisions and policy analyses by developing decision trees that clearly identify potential options currently used by countries as they evaluate national polio vaccine choices. Based on a comprehensive review of the literature we (1) identify the current vaccination options that national health leaders consider for polio vaccination, (2) characterize current practices and factors that appear to influence national and international choices, and (3) assess the evidence of vaccine effectiveness considering sources of variability between countries and uncertainties associated with limitations of the data. With low numbers of cases occurring globally, the management of polio risks might seem like a relatively low priority, but stopping live poliovirus circulation requires making proactive and intentional choices to manage population immunity in the remaining endemic areas and to prevent reestablishment in nonendemic areas. Our analysis shows remarkable variability in the current national polio vaccine product choices and schedules, with combination vaccine options containing inactivated poliovirus vaccine and different formulations of oral poliovirus vaccine making choices increasingly difficult for national health leaders. © 2013 Society for Risk Analysis.

Bounds for Asian basket options

NASA Astrophysics Data System (ADS)

Deelstra, Griselda; Diallo, Ibrahima; Vanmaele, Michèle

2008-09-01

In this paper we propose pricing bounds for European-style discrete arithmetic Asian basket options in a Black and Scholes framework. We start from methods used for basket options and Asian options. First, we use the general approach for deriving upper and lower bounds for stop-loss premia of sums of non-independent random variables as in Kaas et al. [Upper and lower bounds for sums of random variables, Insurance Math. Econom. 27 (2000) 151-168] or Dhaene et al. [The concept of comonotonicity in actuarial science and finance: theory, Insurance Math. Econom. 31(1) (2002) 3-33]. We generalize the methods in Deelstra et al. [Pricing of arithmetic basket options by conditioning, Insurance Math. Econom. 34 (2004) 55-57] and Vanmaele et al. [Bounds for the price of discrete sampled arithmetic Asian options, J. Comput. Appl. Math. 185(1) (2006) 51-90]. Afterwards we show how to derive an analytical closed-form expression for a lower bound in the non-comonotonic case. Finally, we derive upper bounds for Asian basket options by applying techniques as in Thompson [Fast narrow bounds on the value of Asian options, Working Paper, University of Cambridge, 1999] and Lord [Partially exact and bounded approximations for arithmetic Asian options, J. Comput. Finance 10 (2) (2006) 1-52]. Numerical results are included and on the basis of our numerical tests, we explain which method we recommend depending on moneyness and time-to-maturity.

Monitoring protocols: options, approaches, implementation, benefits

USDA-ARS?s Scientific Manuscript database

Monitoring and adaptive management are fundamental concepts to rangeland management across land management agencies and embodied as best management practices for private landowners. Historically, rangeland monitoring was limited to determining impacts or maximizing the potential of specific land use...

Evaluating the potential for justice in urban climate change adaptation in the U.S.

EPA Science Inventory

Conference presentation that introduces the concept of justice as a consideration in evaluating climate change adaptation options. Provides an assessment of ongoing urban sustainability programs and identifies gaps and priority areas.

Thermal Control System for a Small, Extended Duration Lunar Surface Science Platform

NASA Technical Reports Server (NTRS)

Bugby, D.; Farmer, J.; OConnor, B.; Wirzburger, M.; Abel, E.; Stouffer, C.

2010-01-01

The presentation slides include: Introduction: lunar mission definition, Problem: requirements/methodology, Concept: thermal switching options, Analysis: system evaluation, Plans: dual-radiator LHP (loop heat pipe) test bed, and Conclusions: from this study.

Lunar Surface-to-Surface Power Transfer

NASA Technical Reports Server (NTRS)

Kerslake, Thomas W.

2007-01-01

A human lunar outpost, under NASA study for construction in the 2020's, has potential requirements to transfer electric power up to 50-kW across the lunar surface from 0.1 to 10-km distances. This power would be used to operate surface payloads located remotely from the outpost and/or outpost primary power grid. This paper describes concept designs for state-of-the-art technology power transfer subsystems including AC or DC power via cables, beamed radio frequency power and beamed laser power. Power transfer subsystem mass and performance are calculated and compared for each option. A simplified qualitative assessment of option operations, hazards, costs and technology needs is also described. Based on these concept designs and performance analyses, a DC power cabling subsystem is recommended to minimize subsystem mass and to minimize mission and programmatic costs and risks. Avenues for additional power transfer subsystem studies are recommended.

Concept Overview & Preliminary Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruth, Mark

2017-07-12

'H2@Scale' is an opportunity for wide-scale use of hydrogen as an intermediate that carries energy from various production options to multiple uses. It is based on identifying and developing opportunities for low-cost hydrogen production and investigating opportunities for using that hydrogen across the electricity, industrial, and transportation sectors. One of the key production opportunities is use of low-cost electricity that may be generated under high penetrations of variable renewable generators such as wind and solar photovoltaics. The technical potential demand for hydrogen across the sectors is 60 million metric tons per year. The U.S. has sufficient domestic renewable resources somore » that each could meet that demand and could readily meet the demand using a portfolio of generation options. This presentation provides an overview of the concept and the technical potential demand and resources. It also motivates analysis and research on H2@Scale.« less

Wide Field Infra-Red Survey Telescope (WFIRST) 2.4-Meter Mission Study

NASA Technical Reports Server (NTRS)

Content, D.; Aaron, K.; Alplanalp, L.; Anderson, K.; Capps, R.; Chang, Z.; Dooley, J.; Egerman, R.; Goullioud, R.; Klein, D.;

Airspace Technology Demonstration 3 (ATD-3): Multi-Flight Common Route (MFCR) Technology Transfer Document Summary Version 1.0

NASA Technical Reports Server (NTRS)

Sheth, Kapil; Bilimoria, Karl; Amer, Maryam M.; Wang, Easter M.

2017-01-01

This summary document and accompanying technology artifacts satisfy the second of three Research Transition Products (RTPs) defined in the ATD-3 Applied Traffic Flow Management (ATFM) Research Transition Team (RTT) Plan. This transfer consists of NASA's Multi-Flight Common Route (MFCR) research for efficient route corrections for en-route weather avoidance. The MFCR concept builds on the experience of the legacy Dynamic Weather Routes (DWR) and focuses on a better balance of potential savings with ATC acceptability, common route corrections options for multiple flights on similar routings, and better use of existing and/or modern automation for communication and coordination of route change options. All of these capabilities are expected to improve system performance significantly in terms of actual delay-reducing clearances issued to flights compared to that of the DWR tool and operating concept.

Paratransit Integration Symposium Proceedings, October 14, 1977

DOT National Transportation Integrated Search

1978-06-01

Paratransit innovation is considered by DOT/UMTA to be an essential part of the provision of public transportation. A variety of service options, ranging from many-to-many dial-a-ride to subscription ridership, offer cost effective options to convent...

How can health systems research reach the worst-off? A conceptual exploration.

PubMed

Pratt, Bridget; Hyder, Adnan A

2016-11-15

Health systems research is increasingly being conducted in low and middle-income countries (LMICs). Such research should aim to reduce health disparities between and within countries as a matter of global justice. For such research to do so, ethical guidance that is consistent with egalitarian theories of social justice proposes it ought to (amongst other things) focus on worst-off countries and research populations. Yet who constitutes the worst-off is not well-defined. By applying existing work on disadvantage from political philosophy, the paper demonstrates that (at least) two options exist for how to define the worst-off upon whom equity-oriented health systems research should focus: those who are worst-off in terms of health or those who are systematically disadvantaged. The paper describes in detail how both concepts can be understood and what metrics can be relied upon to identify worst-off countries and research populations at the sub-national level (groups, communities). To demonstrate how each can be used, the paper considers two real-world cases of health systems research and whether their choice of country (Uganda, India) and research population in 2011 would have been classified as amongst the worst-off according to the proposed concepts. The two proposed concepts can classify different countries and sub-national populations as worst-off. It is recommended that health researchers (or other actors) should use the concept that best reflects their moral commitments-namely, to perform research focused on reducing health inequalities or systematic disadvantage more broadly. If addressing the latter, it is recommended that they rely on the multidimensional poverty approach rather than the income approach to identify worst-off populations.

[Treatment strategy and planning for pilon fractures].

PubMed

Mittlmeier, Thomas; Wichelhaus, Alice

2017-08-01

Pilon fractures are mainly severe and prognostically serious injuries with a high rate of relevant soft tissue involvement. The adequate decision making and choice of treatment in the early phase of trauma are of paramount importance for the final outcome. This essentially encompasses the management of the soft tissue damage, the surgical planning and the differentiated selection of procedures. Most concepts of staged treatment nowadays offer a wide range of options which are integrated into expert-based algorithms. The aim of the present analysis was to display the strategy variations for the treatment of pilon fractures taking into account the advantages and disadvantages of the corresponding treatment concepts. A staged procedure including primary closed reduction employing ligamentotaxis and fixation of the joints of the hindfoot via tibiocalcaneal metatarsal fixation offers a safe basis for consecutive imaging and the selection of specific approaches for definitive reconstruction. A simultaneous reconstruction and fixation of the fibula during the primary intervention are generally not recommended in order to avoid any limitations for subsequent reconstructive procedures. A time frame for definitive reconstruction covers a period of up to 3 weeks after trauma and allows a detailed planning considering the individual dynamics of the soft tissue situation and any logistic requirements. For the choice of the definitive treatment concept a wide range of procedures and implants are available. There are also valid concepts for primary treatment of defined fracture constellations while primary arthrodesis represents a solution in cases of major destruction of the joint surface. Knowledge of the multiple procedural variations for pilon fracture treatment creates the basis to optimize the treatment modalities and to take into account individual parameters of the fracture.

Modular System to Enable Extravehicular Activity

NASA Technical Reports Server (NTRS)

Sargusingh, Miriam J.

2011-01-01

The ability to perform extravehicular activity (EVA), both human and robotic, has been identified as a key component to space missions to support such operations as assembly and maintenance of space system (e.g. construction and maintenance of the International Space Station), and unscheduled activities to repair an element of the transportation and habitation systems that can only be accessed externally and via unpressurized areas. In order to make human transportation beyond lower earth orbit (BLEO) practical, efficiencies must be incorporated into the integrated transportation systems to reduce system mass and operational complexity. Affordability is also a key aspect to be considered in space system development; this could be achieved through commonality, modularity and component reuse. Another key aspect identified for the EVA system was the ability to produce flight worthy hardware quickly to support early missions and near Earth technology demonstrations. This paper details a conceptual architecture for a modular extravehicular activity system (MEVAS) that would meet these stated needs for EVA capability that is affordable, and that could be produced relatively quickly. Operational concepts were developed to elaborate on the defined needs and define the key capabilities, operational and design constraints, and general timelines. The operational concept lead to a high level design concept for a module that interfaces with various space transportation elements and contains the hardware and systems required to support human and telerobotic EVA; the module would not be self-propelled and would rely on an interfacing element for consumable resources. The conceptual architecture was then compared to EVA Systems used in the Shuttle Orbiter, on the International Space Station to develop high level design concepts that incorporate opportunities for cost savings through hardware reuse, and quick production through the use of existing technologies and hardware designs. An upgrade option was included to make use of the developing suitport technologies.

Decision-making in healthy children, adolescents and adults explained by the use of increasingly complex proportional reasoning rules.

PubMed

Huizenga, Hilde M; Crone, Eveline A; Jansen, Brenda J

2007-11-01

In the standard Iowa Gambling Task (IGT), participants have to choose repeatedly from four options. Each option is characterized by a constant gain, and by the frequency and amount of a probabilistic loss. Crone and van der Molen (2004) reported that school-aged children and even adolescents show marked deficits in IGT performance. In this study, we have re-analyzed the data with a multivariate normal mixture analysis to show that these developmental changes can be explained by a shift from unidimensional to multidimensional proportional reasoning (Siegler, 1981; Jansen & van der Maas, 2002). More specifically, the results show a gradual shift with increasing age from (a) guessing with a slight tendency to consider frequency of loss to (b) focusing on frequency of loss, to (c) considering both frequency and amount of probabilistic loss. In the latter case, participants only considered options with low-frequency loss and then chose the option with the lowest amount of loss. Performance improved in a reversed task, in which punishment was placed up front and gain was delivered unexpectedly. In this reversed task, young children are guessing with already a slight tendency to consider both the frequency and amount of gain; this strategy becomes more pronounced with age. We argue that these findings have important implications for the interpretation of IGT performance, as well as for methods to analyze this performance.

A capital idea. Bonds and nontraditional financing options.

PubMed

Wareham, Therese L

2004-05-01

Not-for-profit healthcare organizations have four basic sources of capital: internal sources, philanthropy, asset sales, and external sources. External sources, in particular, offer a wealth of options that are important for such organizations--especially those facing significant capital shortfalls--to consider. External sources include bond offerings and nontraditional offerings, such as receivables financing, off-balance-sheet options, real estate investment trusts, and subordinated securities.

The conceptual solutions concerning decommissioning and dismantling of Russian civil nuclear powered ships

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kulikov, Konstantin N.; Nizamutdinov, Rinat A.; Abramov, Andrey N.

From 1959 up to 1991 nine civil nuclear powered ships were built in Russia: eight ice-breakers and one lash lighter carrier (cargo ship). At the present time three of them were taking out of service: ice-breaker 'Lenin' is decommissioned as a museum and is set for storage in the port of Murmansk, nuclear ice-breakers 'Arktika' and 'Sibir' are berthing. The ice-breakers carrying rad-wastes appear to be a possible source of radiation contamination of Murmansk region and Kola Bay because the ship long-term storage afloat has the negative effect on hull's structures. As the result of this under the auspices ofmore » the Federal Targeted Program 'Nuclear and Radiation Safety of Russia for 2008 and the period until 2015' the conception and projects of decommissioning of nuclear-powered ships are developed by the State corporation Rosatom with the involvement of companies of United Shipbuilding Corporation. In developing the principal provisions of conception of decommissioning and dismantling of icebreakers the technical and economic assessment of dismantling options in ship-repairing enterprises of North-West of Russia was performed. The paper contains description of options, research procedure, analysis of options of decommissioning and dismantling of nuclear ice-breakers, taking into account the principle of optimization of potential radioactive effect to personnel, human population and environment. The report's conclusions contain the recommendations for selection of option for development of nuclear icebreaker decommissioning and dismantling projects. (authors)« less

Job sharing: a viable option for the clinical nurse specialist.

PubMed

Haibeck, S V; Howard, J L

1991-01-01

NUMEROUS WORK TIME options have been developed to attract, retain and meet the various needs of nurses. Job sharing, a work option little known to nurses, can be a successful alternative for balancing professional and personal lifestyle. The business literature supports job sharing and other innovative work options as successful mechanisms in retaining quality employees in their respective professions. After exploring the literature in this area, a proposal for job sharing the oncology clinical nurse specialist (CNS) position was presented to the Personnel Director and Vice President of Nursing at our institution. The proposal addressed the advantages and disadvantages of the concept. These included: (1) scheduling flexibility, (2) reduced absenteeism and turnover, (3) increased productivity, (4) handling fringe benefits, and (5) job satisfaction. The proposal was accepted, and the job sharing position has been successfully implemented for more than 2 years now. This paper describes issues relevant to designing and implementing job sharing in a CNS position.

The Importance of Measuring Strength-of-Preference Scores for Health Care Options in Preference-Sensitive Care

PubMed Central

Crump, R. Trafford; Llewellyn-Thomas, Hilary A.

2012-01-01

Objective The objective was to determine whether a paired-comparison/leaning scale method: a) could feasibly be used to elicit strength-of-preference scores for elective health care options in large community-based survey settings; and b) could reveal preferential sub-groups that would have been overlooked if only a categorical-response format had been used. Study Design Medicare beneficiaries in four different regions of the United States were interviewed in person. Participants considered 8 clinical scenarios, each with 2 to 3 different health care options. For each scenario, participants categorically selected their favored option, then indicated how strongly they favored that option relative to the alternative on a paired-comparison bi-directional Leaning Scale. Results Two hundred and two participants were interviewed. For 7 of the 8 scenarios, a clear majority (> 50%) indicated that, overall, they categorically favored one option over the alternative(s). However, the bi-directional strength-of-preference Leaning Scale scores revealed that, in 4 scenarios, for half of those participants, their preference for the favored option was actually “weak” or “neutral”. Conclusion Investigators aiming to assess population-wide preferential attitudes towards different elective health care scenarios should consider gathering ordinal-level strength-of-preference scores and could feasibly use the paired-comparison/bi-directional Leaning Scale to do so. PMID:22494579

Experimental Test Concept for a Cargo Data Interchange System (CARDIS) : Volume 1. Text.

DOT National Transportation Integrated Search

1976-05-01

This report includes the recommended CARDIS experimental test system functional capabilities. It identifies the CARDIS functions that are inherent to an information exchange capability and optional systems which are required by the transportation rel...

Practice Options and Decision Making for Dental Students.

ERIC Educational Resources Information Center

Manski, Richard J.

1987-01-01

One dental school implemented in its fourth-year curriculum an intensive simulation exercise to teach students the application of fundamental economic concepts such as capital costs, leasehold improvements, operating expenses, working capital, and financial risk in dental practice. (MSE)

Experimental Test Concept for a Cargo Data Interchange System (CARDIS) : Volume 2. Appendixes.

DOT National Transportation Integrated Search

1976-05-01

This report includes the recommended CARDIS experimental test system functional capabilities. It identifies the CARDIS functions that are inherent to an information exchange capability and optional systems which are required by the transportation rel...

Space station systems analysis study. Part 2, volume 3: Appendixes, Book 2: Supporting data (7 through 18)

NASA Technical Reports Server (NTRS)

1977-01-01

Topics discussed include: (1) design considerations for a MARS sample return laboratory module for space station investigations; (2) crew productivity as a function of work shift arrangement; (3) preliminary analysis of the local logistics problem on the space construction base; (4) mission hardware construction operational flows and timelines; (5) orbit transfer vehicle concept definition; (6) summary of results and findings of space processing working review; (7) crew and habitability subsystem (option L); (8) habitability subsystem considerations for shuttle tended option L; (9) orbiter utilization in manned sortie missions; (10) considerations in definition of space construction base standard module configuration (option L); (11) guidance, control, and navigation subsystems; and (12) system and design tradeoffs.

Whole-organ re-engineering: a regenerative medicine approach to digestive organ replacement.

PubMed

Yagi, Hiroshi; Soto-Gutierrez, Alejandro; Kitagawa, Yuko

2013-06-01

Recovery from end-stage organ failure presents a challenge for the medical community, considering the limitations of extracorporeal assist devices and the shortage of donors when organ replacement is needed. There is a need for new methods to promote recovery from organ failure and regenerative medicine is an option that should be considered. Recent progress in the field of tissue engineering has opened avenues for potential clinical applications, including the use of microfluidic devices for diagnostic purposes, and bioreactors or cell/tissue-based therapies for transplantation. Early attempts to engineer tissues produced thin, planar constructs; however, recent approaches using synthetic scaffolds and decellularized tissue have achieved a more complex level of tissue organization in organs such as the urinary bladder and trachea, with some success in clinical trials. In this context, the concept of decellularization technology has been applied to produce whole organ-derived scaffolds by removing cellular content while retaining all the necessary vascular and structural cues of the native organ. In this review, we focus on organ decellularization as a new regenerative medicine approach for whole organs, which may be applied in the field of digestive surgery.

Satellite power system: Concept development and evaluation program, reference system report

NASA Technical Reports Server (NTRS)

1979-01-01

The Satellite Power System (SPS) Reference System is discussed and the technical and operational information required in support of environmental, socioeconomic, and comparative assessment studies are emphasized. The reference System concept features a gallium-aluminum-arsenide, and silicon solar cell options. Other aspects of an SPS are the construction of bases in space, launch and mission control bases on earth, and fleets of various transportation vehicles to support the construction and maintenance operations of the satellites.

Thermal control of high energy nuclear waste, space option. [mathematical models

NASA Technical Reports Server (NTRS)

Peoples, J. A.

1979-01-01

Problems related to the temperature and packaging of nuclear waste material for disposal in space are explored. An approach is suggested for solving both problems with emphasis on high energy density waste material. A passive cooling concept is presented which utilized conduction rods that penetrate the inner core. Data are presented to illustrate the effectiveness of the rods and the limit of their capability. A computerized thermal model is discussed and developed for the cooling concept.

U.S. Navy Employment Options for Unmanned Surface Vehicles (USVs)

DTIC Science & Technology

2013-01-01

sessions, modifying and extrapolating from the original concepts. Assessing Suitability We assessed the suitability of the USV concepts of employment...test and demonstration 1 U.S. Department of the Navy, The Navy Unmanned Surface Vehicle (USV) Master Plan, July 23, 2007. The TRL system was originally ...of interest, the USV uses its sonar to capture imagery. The USV then returns to its point of origin for recovery of the sonar system and the newly

Opinion and Special Articles: Loan forgiveness options for young neurologists: Current landscape and practice implications.

PubMed

George, Benjamin P; Dorsey, E Ray; Grischkan, Justin A

2017-04-11

Increasing education debt has led to the availability of a variety of loan forgiveness options including the Department of Education's Public Service Loan Forgiveness (PSLF) program. This article discusses the current landscape of loan forgiveness options including trends in PSLF for rising neurology trainees, and implications for choices in specialization, employment, practice location, and the pursuit of an academic career. We further provide guidance on how to navigate the various loan forgiveness options that neurology residents and fellows may consider. © 2017 American Academy of Neurology.

Decision-making on preimplantation genetic diagnosis and prenatal diagnosis: a challenge for couples with hereditary breast and ovarian cancer.

PubMed

Derks-Smeets, I A P; Gietel-Habets, J J G; Tibben, A; Tjan-Heijnen, V C G; Meijer-Hoogeveen, M; Geraedts, J P M; van Golde, R; Gomez-Garcia, E; van den Bogaart, E; van Hooijdonk, M; de Die-Smulders, C E M; van Osch, L A D M

2014-05-01

How do couples with a BRCA1/2 mutation decide on preimplantation genetic diagnosis (PGD) and prenatal diagnosis (PND) for hereditary breast and ovarian cancer syndrome (HBOC)? BRCA couples primarily classify PGD and/or PND as reproductive options based on the perceived severity of HBOC and moral considerations, and consequently weigh the few important advantages of PGD against numerous smaller disadvantages. Awareness of PGD is generally low among persons at high risk for hereditary cancers. Most persons with HBOC are in favour of offering PGD for BRCA1/2 mutations, although only a minority would consider this option for themselves. Studies exploring the motivations for using or refraining from PGD among well-informed BRCA carriers of reproductive age are lacking. We studied the reproductive decision-making process by interviewing a group of well-informed, reproductive aged couples carrying a BRCA1/2 mutation, regarding their decisional motives and considerations. This exploratory, qualitative study investigated the motives and considerations taken into account by couples with a BRCA1/2 mutation and who have received extensive counselling on PGD and PND and have made a well-informed decision regarding this option. Eighteen couples took part in focus group and dyadic interviews between January and September 2012. Semi-structured focus groups were conducted containing two to four couples, assembled based on the reproductive method the couple had chosen: PGD (n = 6 couples) or conception without testing (n = 8 couples). Couples who had chosen PND for BRCA (n = 4) were interviewed dyadically. Two of the women, of whom one had chosen PND and the other had chosen no testing, had a history of breast cancer. None of the couples who opted for PGD or conception without testing found the use of PND, with possible pregnancy termination, acceptable. PND users chose this method because of decisive, mainly practical reasons (natural conception, high chance of favourable outcome). Motives and considerations regarding PGD largely overlapped between PGD users, PND users and non-users, all mentioning some significant advantages (e.g. protecting the child and family from the mutation) and many smaller disadvantages (e.g. the necessity of in vitro fertilization (IVF), low chance of pregnancy by IVF/PGD). For female carriers, the safety of hormonal stimulation and the time required for PGD before undergoing preventive surgeries were important factors in the decision. Non-users expressed doubts about the moral justness of their decision afterwards and emphasized the impact the decision still had on their lives. The interviewed couples were at different stages in their chosen trajectory, up to 3 years after completion. This may have led to recall bias of original motives and considerations. Couples who did not actively seek information about PGD were excluded. Therefore the results may not be readily generalizable to all BRCA couples. The perceived severity of HBOC and, for female carriers, the safety of hormonal stimulation and the time frames for PGD planning before preventive surgeries are essential items BRCA couples consider in reproductive decision-making. The emotional impact of this decision should not be underestimated; especially non-users may experience feelings of doubt or guilt up to several years afterwards. PGD counselling with tailored information addressing these items and decisional support in order to guarantee well-informed decision-making is needed. This study was funded by the Dutch breast cancer foundation Stichting Pink Ribbon, grant number 2010.PS11.C74. None of the authors have competing interests to declare. Not applicable.

Physiotherapists use a great variety of motor learning options in neurological rehabilitation, from which they choose through an iterative process: a retrospective think-aloud study.

PubMed

Kleynen, Melanie; Moser, Albine; Haarsma, Frederike A; Beurskens, Anna J; Braun, Susy M

2017-08-01

The goal of this study was to examine which motor learning options are applied by experienced physiotherapists in neurological rehabilitation, and how they choose between the different options. A descriptive qualitative approach was used. A purposive sample of five expert physiotherapists from the neurological ward of a rehabilitation center participated. Data were collected using nine videotaped therapy situations. During retrospective think-aloud interviews, the physiotherapists were instructed to constantly "think aloud" while they were watching their own videos. Five "operators" were identified: "act", "know", "observe", "assess" and "argue". The "act" operator consisted of 34 motor learning options, which were clustered into "instruction", "feedback" and "organization". The "know", "observe", "assess" and "argue" operators explained how therapists chose one of these options. The four operators seem to be interrelated and together lead to a decision to apply a particular motor learning option. Results show that the participating physiotherapists used a great variety of motor learning options in their treatment sessions. Further, the decision-making process with regard to these motor learning options was identified. Results may support future intervention studies that match the content and process of therapy in daily practice. The study should be repeated with other physiotherapists. Implications for Rehabilitation The study provided insight into the way experienced therapist handle the great variety of possible motor learning options, including concrete ideas on how to operationalize these options in specific situations. Despite differences in patients' abilities, it seems that therapists use the same underlying clinical reasoning process when choosing a particular motor learning option. Participating physiotherapists used more than the in guidelines suggested motor learning options and considered more than the suggested factors, hence adding practice based options of motor learning to the recommended ones in the guidelines. A think-aloud approach can be considered for peer-to-peer and student coaching to enhance discussion on the motor learning options applied and the underlying choices and to encourage research by practicing clinicians.

A multi-criteria decision analysis assessment of waste paper management options.

PubMed

Hanan, Deirdre; Burnley, Stephen; Cooke, David

2013-03-01

The use of Multi-criteria Decision Analysis (MCDA) was investigated in an exercise using a panel of local residents and stakeholders to assess the options for managing waste paper on the Isle of Wight. Seven recycling, recovery and disposal options were considered by the panel who evaluated each option against seven environmental, financial and social criteria. The panel preferred options where the waste was managed on the island with gasification and recycling achieving the highest scores. Exporting the waste to the English mainland for incineration or landfill proved to be the least preferred options. This research has demonstrated that MCDA is an effective way of involving community groups in waste management decision making. Copyright © 2012 Elsevier Ltd. All rights reserved.

Multiple Restart Testing of a Stainless Steel Sodium Heat Pipe Module

NASA Astrophysics Data System (ADS)

Martin, James; Mireles, Omar; Reid, Robert

2005-02-01

A heat pipe cooled reactor is one of several candidate reactor concepts being considered for space power and propulsion systems to support future space exploration activities. Long life heat pipe modules, with concepts verified through a combination of theoretical analysis and experimental evaluations, would be necessary to establish the viability of this option. A number of stainless steel/sodium heat pipe modules have been designed and fabricated to support experimental testing of a Safe Affordable Fission Engine (SAFE) project, a 100-kWt core design pursued jointly by the Marshall Space Flight Center and the Los Alamos National Laboratory. One of the SAFE heat pipe modules was successfully subjected to over 200 restarts, examining the behavior of multiple passive freeze/thaw operations. Typical operation included a 1-hour startup to an average evaporator temperature of 1000 K followed by a 15-minute hold at temperature. Nominal maximum input power to the evaporator (measured at the power supply) during the hold period was 1.9 kW, with approximately 1.6 kW calculated as the axial power transfer to the condenser (the 300W difference was lost to environment at the evaporator surface). Between heating cycles the module was cooled to less than 325 K, returning the sodium to a frozen state in preparation for the next startup cycle.

Mitochondrial encephalopathy, lactic acidosis, and strokelike episodes: basic concepts, clinical phenotype, and therapeutic management of MELAS syndrome.

PubMed

Sproule, Douglas M; Kaufmann, Petra

2008-10-01

Since the initial description almost 25 years ago, the syndrome of mitochondrial encephalopathy, lactic acidosis, and strokelike episodes (MELAS) has been a useful model to study the complex interplay of factors that define mitochondrial disease. This syndrome, most commonly caused by an A-to-G transition mutation at position 3243 of the mitochondrial genome, is typified by characteristic neurological manifestations including seizures, encephalopathy, and strokelike episodes, as well as other frequent secondary manifestations including short stature, cognitive impairment, migraines, depression, cardiomyopathy, cardiac conduction defects, and diabetes mellitus. In this review, we discuss the history, pathogenesis, clinical features, and diagnostic and management strategies of mitochondrial disease in general and of MELAS in particular. We explore features of mitochondrial genetics, including the concepts of heteroplasmy, mitotic segregation, and threshold effect, as a basis for understanding the variability and complicated inheritance patterns seen with this group of diseases. We also describe systemic manifestations of MELAS-associated mutations, including cardiac, renal, endocrine, gastrointestinal, and endothelial abnormalities and pathology, as well as the hypothetical role of derangements to COX enzymatic function in driving the unique pathology and clinical manifestations of MELAS. Although therapeutic options for MELAS and other mitochondrial diseases remain limited, and recent trials have been disappointing, we also consider current and potential therapeutic modalities.

Global precipitation measurement (GPM)

NASA Astrophysics Data System (ADS)

Neeck, Steven P.; Flaming, Gilbert M.; Adams, W. James; Smith, Eric A.

2001-12-01

The National Aeronautics and Space Administration (NASA) is studying options for future space-based missions for the EOS Follow-on Era (post 2003), building upon the measurements made by Pre-EOS and EOS First Series Missions. One mission under consideration is the Global Precipitation Measurement (GPM), a cooperative venture of NASA, Japan, and other international partners. GPM will capitalize on the experience of the highly successful Tropical Rainfall Measurement Mission (TRMM). Its goal is to extend the measurement of rainfall to high latitudes with high temporal frequency, providing a global data set every three hours. A reference concept has been developed consisting of an improved TRMM-like primary satellite with precipitation radar and microwave radiometer to make detailed and accurate estimates of the precipitation structure and a constellation of small satellites flying compact microwave radiometers to provide the required temporal sampling of highly variable precipitation systems. Considering that DMSP spacecraft equipped with SSMIS microwave radiometers, successor NPOESS spacecraft equipped with CMIS microwave radiometers, and other relevant international systems are expected to be in operation during the timeframe of the reference concept, the total number of small satellites required to complete the constellation will be reduced. A nominal plan is to begin implementation in FY'03 with launches in 2007. NASA is presently engaged in advanced mission studies and advanced instrument technology development related to the mission.

Does the Constellation Program Offer Opportunities to Achieve Space Science Goals in Space?

NASA Technical Reports Server (NTRS)

Thronson, Harley A.; Lester, Daniel F.; Dissel, Adam F.; Folta, David C.; Stevens, John; Budinoff, Jason G.

2008-01-01

Future space science missions developed to achieve the most ambitious goals are likely to be complex, large, publicly and professionally very important, and at the limit of affordability. Consequently, it may be valuable if such missions can be upgraded, repaired, and/or deployed in space, either with robots or with astronauts. In response to a Request for Information from the US National Research Council panel on Science Opportunities Enabled by NASA's Constellation System, we developed a concept for astronaut-based in-space servicing at the Earth-Moon L1,2 locations that may be implemented by using elements of NASA's Constellation architecture. This libration point jobsite could be of great value for major heliospheric and astronomy missions operating at Earth-Sun Lagrange points. We explored five alternative servicing options that plausibly would be available within about a decade. We highlight one that we believe is both the least costly and most efficiently uses Constellation hardware that appears to be available by mid-next decade: the Ares I launch vehicle, Orion/Crew Exploration Vehicle, Centaur vehicle, and an airlock/servicing node developed for lunar surface operations. Our concept may be considered similar to the Apollo 8 mission: a valuable exercise before descent by astronauts to the lunar surface.

Investigational chemotherapy and novel pharmacokinetic mechanisms for the treatment of breast cancer brain metastases.

PubMed

Shah, Neal; Mohammad, Afroz S; Saralkar, Pushkar; Sprowls, Samuel A; Vickers, Schuyler D; John, Devin; Tallman, Rachel M; Lucke-Wold, Brandon P; Jarrell, Katherine E; Pinti, Mark; Nolan, Richard L; Lockman, Paul R

2018-03-28

In women, breast cancer is the most common cancer diagnosis and second most common cause of cancer death. More than half of breast cancer patients will develop metastases to the bone, liver, lung, or brain. Breast cancer brain metastases (BCBM) confers a poor prognosis, as current therapeutic options of surgery, radiation, and chemotherapy rarely significantly extend life and are considered palliative. Within the realm of chemotherapy, the last decade has seen an explosion of novel chemotherapeutics involving targeting agents and unique dosage forms. We provide a historical overview of BCBM chemotherapy, review the mechanisms of new agents such as poly-ADP ribose polymerase inhibitors, cyclin-dependent kinase 4/6 inhibitors, phosphatidyl inositol 3-kinaseinhibitors, estrogen pathway antagonists for hormone-receptor positive BCBM; tyrosine kinase inhibitors, antibodies, and conjugates for HER2 + BCBM; repurposed cytotoxic chemotherapy for triple negative BCBM; and the utilization of these new agents and formulations in ongoing clinical trials. The mechanisms of novel dosage formulations such as nanoparticles, liposomes, pegylation, the concepts of enhanced permeation and retention, and drugs utilizing these concepts involved in clinical trials are also discussed. These new treatments provide a promising outlook in the treatment of BCBM. Copyright © 2018 Elsevier Ltd. All rights reserved.

A cost engineered launch vehicle for space tourism

NASA Astrophysics Data System (ADS)

Koelle, -Ing. Dietrich E., , Dr.

1999-09-01

The paper starts with a set of major requirements for a space tourism vehicle and discusses major vehicle options proposed for this purpose. It seems that the requirements can be met best with a Ballistic SSTO Vehicle which has the additional advantage of lowest development cost compared to other launch vehicle options — important for a commercial development venture. The BETA Ballistic Reusable Vehicle Concept is characterized by the plug nozzle cluster engine configuration where the plug nozzle serves also as base plate and re-entry heat shield. In this case no athmospheric turn maneuver is required (as in case-of the front-entry Delta-Clipper DC-Y concept). In our specific case for space tourism this mode has the avantage that the forces at launch and reentry are in exactly the same direction, easing passenger seating arrangements. The second basic advantage is the large available volume on top of the vehicle providing ample space for passenger accomodation, visibility and volume for zero-g experience (free floating), one of the major passenger mission requirements. An adequate passenger cabin design for 100 passengers is presented, as well as the modern BETA-STV Concept with its mass allocations.

Evolvable Mars Campaign Long Duration Habitation Strategies: Architectural Approaches to Enable Human Exploration Missions

NASA Technical Reports Server (NTRS)

Simon, Matthew A.; Toups, Larry; Howe, A. Scott; Wald, Samuel I.

2015-01-01

The Evolvable Mars Campaign (EMC) is the current NASA Mars mission planning effort which seeks to establish sustainable, realistic strategies to enable crewed Mars missions in the mid-2030s timeframe. The primary outcome of the Evolvable Mars Campaign is not to produce "The Plan" for sending humans to Mars, but instead its intent is to inform the Human Exploration and Operations Mission Directorate near-term key decisions and investment priorities to prepare for those types of missions. The FY'15 EMC effort focused upon analysis of integrated mission architectures to identify technically appealing transportation strategies, logistics build-up strategies, and vehicle designs for reaching and exploring Mars moons and Mars surface. As part of the development of this campaign, long duration habitats are required which are capable of supporting crew with limited resupply and crew abort during the Mars transit, Mars moons, and Mars surface segments of EMC missions. In particular, the EMC design team sought to design a single, affordable habitation system whose manufactured units could be outfitted uniquely for each of these missions and reused for multiple crewed missions. This habitat system must provide all of the functionality to safely support 4 crew for long durations while meeting mass and volume constraints for each of the mission segments set by the chosen transportation architecture and propulsion technologies. This paper describes several proposed long-duration habitation strategies to enable the Evolvable Mars Campaign through improvements in mass, cost, and reusability, and presents results of analysis to compare the options and identify promising solutions. The concepts investigated include several monolithic concepts: monolithic clean sheet designs, and concepts which leverage the co-manifested payload capability of NASA's Space Launch System (SLS) to deliver habitable elements within the Universal Payload Adaptor between the SLS upper stage and the Orion/Service module on the top of the vehicle. Multiple modular habitat options for Mars surface and in-space missions are also considered with various functionality and volume splits between modules to find the best balance of reducing the single largest mass which must be delivered to a destination and reducing the number of separate elements which must be launched. Analysis results presented for each of these concepts in this paper include mass/volume/power sizing using parametric sizing tools, identification of unique operational constraints, and limited comments on the additional impacts of reusability/dormancy on system design. Finally, recommendations will be made for promising solutions which will be carried forward for consideration in the Evolvable Mars Campaign work.

77 FR 25319 - Commodity Options

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-27

... marketing loan program would not be considered swaps.\\25\\ \\25\\ After CFTC staff reviewed the ``options to redeem'' with both USDA staff members responsible for managing the cotton marketing loan program and industry representatives from Amcot (an association of US cotton marketing cooperatives), the Commission...

Mars ISRU for Production of Mission Critical Consumables - Options, Recent Studies, and Current State of the Art

NASA Technical Reports Server (NTRS)

Sanders, G. B.; Paz, A.; Oryshchyn, L.; Araghi, K.; Muscatello, A.; Linne, D.; Kleinhenz, J.; Peters, T.

2015-01-01

In 1978, a ground breaking paper titled, "Feasibility of Rocket Propellant Production on Mars" by Ash, Dowler, and Varsi discussed how ascent propellants could be manufactured on the Mars surface from carbon dioxide collected from the atmosphere to reduce launch mass. Since then, the concept of making mission critical consumables such as propellants, fuel cell reactants, and life support consumables from local resources, commonly known as In-Situ Resource Utilization (ISRU), for robotic and human missions to Mars has been studied many times. In the late 1990's, NASA initiated a series of Mars Human Design Reference Missions (DRMs), the first of which was released in 1997. These studies primarily focused on evaluating the impact of making propellants on Mars for crew ascent to Mars orbit, but creating large caches of life support consumables (water & oxygen) as a backup for regenerative life support systems for long-duration surface stays (>500 days) was also considered in Mars DRM 3.0. Until science data from the Mars Odyssey orbiter and subsequent robotic missions revealed that water may be widely accessable across the surface of Mars, prior Mars ISRU studies were limited to processing Mars atmospheric resources (carbon dioxide, nitrogen, argon, oxygen, and water vapor). In December 2007, NASA completed the Mars Human Design Reference Architecture (DRA) 5.0 study which considered water on Mars as a potential resource for the first time in a human mission architecture. While knowledge of both water resources on Mars and the hardware required to excavate and extract the water were very preliminary, the study concluded that a significant reduction in mass and significant enhancements to the mission architecture were possible if Mars water resources were utilized. Two subsequent Mars ISRU studies aimed at reexamining ISRU technologies, processing options, and advancements in the state-of-the-art since 2007 and to better understand the volume and packaging associated with Mars ISRU systems further substantiated the preliminary results from the Mars DRA 5.0 study. This paper will provide an overview of Mars ISRU consumable production options, the analyses, results, and conclusions from the Mars DRA 5.0 (2007), Mars Collaborative (2013), and Mars ISRU Payload for the Supersonic Retro Propulsion (2014) mission studies, and the current state-of-the-art of Mars ISRU technologies and systems. The paper will also briefly discuss the mission architectural implications associated with Mars resource and ISRU processing options.

Video rate morphological processor based on a redundant number representation

NASA Astrophysics Data System (ADS)

Kuczborski, Wojciech; Attikiouzel, Yianni; Crebbin, Gregory A.

1992-03-01

This paper presents a video rate morphological processor for automated visual inspection of printed circuit boards, integrated circuit masks, and other complex objects. Inspection algorithms are based on gray-scale mathematical morphology. Hardware complexity of the known methods of real-time implementation of gray-scale morphology--the umbra transform and the threshold decomposition--has prompted us to propose a novel technique which applied an arithmetic system without carrying propagation. After considering several arithmetic systems, a redundant number representation has been selected for implementation. Two options are analyzed here. The first is a pure signed digit number representation (SDNR) with the base of 4. The second option is a combination of the base-2 SDNR (to represent gray levels of images) and the conventional twos complement code (to represent gray levels of structuring elements). Operation principle of the morphological processor is based on the concept of the digit level systolic array. Individual processing units and small memory elements create a pipeline. The memory elements store current image windows (kernels). All operation primitives of processing units apply a unified direction of digit processing: most significant digit first (MSDF). The implementation technology is based on the field programmable gate arrays by Xilinx. This paper justified the rationality of a new approach to logic design, which is the decomposition of Boolean functions instead of Boolean minimization.

Field to fuel: developing sustainable biorefineries.

PubMed

Jenkins, Robin; Alles, Carina

2011-06-01

Life-cycle assessment (LCA) can be used as a scientific decision support technique to quantify the environmental implications of various biorefinery process, feedstock, and integration options. The goal of DuPont's integrated corn biorefinery (ICBR) project, a cost-share project with the United States Department of Energy, was to demonstrate the feasibility of a cellulosic ethanol biorefinery concept. DuPont used LCA to guide research and development to the most sustainable cellulosic ethanol biorefinery design in its ICBR project and will continue to apply LCA in support of its ongoing effort with joint venture partners. Cellulosic ethanol is a biofuel which has the potential to provide a sustainable solution to the nation's growing concerns around energy supply and climate change. A successful biorefinery begins with sustainable removal of biomass from the field. Michigan State University (MSU) used LCA to estimate the environmental performance of corn grain, corn stover, and the corn cob portion of the stover, grown under various farming practices for several corn growing locations in the United States Corn Belt. In order to benchmark the future technology options for producing cellulosic ethanol with existing technologies, LCA results for fossil energy consumption and greenhouse gas (GHG) emissions are compared to alternative ethanol processes and conventional gasoline. Preliminary results show that the DuPont ICBR outperforms gasoline and other ethanol technologies in the life-cycle impact categories considered here.

Pegvisomant in acromegaly: an update.

PubMed

Giustina, A; Arnaldi, G; Bogazzi, F; Cannavò, S; Colao, A; De Marinis, L; De Menis, E; Degli Uberti, E; Giorgino, F; Grottoli, S; Lania, A G; Maffei, P; Pivonello, R; Ghigo, E

2017-06-01

In 2007, we published an opinion document to review the role of pegvisomant (PEG) in the treatment of acromegaly. Since then, new evidence emerged on the biochemical and clinical effects of PEG and on its long-term efficacy and safety. We here reviewed the emerging aspects of the use of PEG in clinical practice in the light of the most recent literature. The clinical use of PEG is still suboptimal, considering that it remains the most powerful tool to control IGF-I in acromegaly allowing to obtain, with a pharmacological treatment, the most important clinical effects in terms of signs and symptoms, quality of life and comorbidities. The number of patients with acromegaly exposed to PEG worldwide has become quite elevated and the prolonged follow-up allows now to deal quite satisfactorily with many clinical issues including major safety issues, such as the concerns about possible tumour (re)growth under PEG. The positive or neutral impact of PEG on glucose metabolism has been highlighted, and the clinical experience, although limited, with sleep apnoea and pregnancy has been reviewed. Finally, the current concept of somatostatin receptor ligands (SRL) resistance has been addressed, in order to better define the acromegaly patients to whom the PEG option may be offered. PEG increasingly appears to be an effective and safe medical option for many patients not controlled by SRL but its use still needs to be optimized.

"Best Case/Worst Case": Qualitative Evaluation of a Novel Communication Tool for Difficult in-the-Moment Surgical Decisions.

PubMed

Kruser, Jacqueline M; Nabozny, Michael J; Steffens, Nicole M; Brasel, Karen J; Campbell, Toby C; Gaines, Martha E; Schwarze, Margaret L

2015-09-01

To evaluate a communication tool called "Best Case/Worst Case" (BC/WC) based on an established conceptual model of shared decision-making. Focus group study. Older adults (four focus groups) and surgeons (two focus groups) using modified questions from the Decision Aid Acceptability Scale and the Decisional Conflict Scale to evaluate and revise the communication tool. Individuals aged 60 and older recruited from senior centers (n = 37) and surgeons from academic and private practices in Wisconsin (n = 17). Qualitative content analysis was used to explore themes and concepts that focus group respondents identified. Seniors and surgeons praised the tool for the unambiguous illustration of multiple treatment options and the clarity gained from presentation of an array of treatment outcomes. Participants noted that the tool provides an opportunity for in-the-moment, preference-based deliberation about options and a platform for further discussion with other clinicians and loved ones. Older adults worried that the format of the tool was not universally accessible for people with different educational backgrounds, and surgeons had concerns that the tool was vulnerable to physicians' subjective biases. The BC/WC tool is a novel decision support intervention that may help facilitate difficult decision-making for older adults and their physicians when considering invasive, acute medical treatments such as surgery. © 2015, Copyright the Authors Journal compilation © 2015, The American Geriatrics Society.

Deciding Where to Turn: A Qualitative Investigation of College Students' Helpseeking Decisions After Sexual Assault.

PubMed

DeLoveh, Heidi L M; Cattaneo, Lauren Bennett

2017-03-01

Sexual assault is a widespread problem on college campuses that has been the subject of substantial attention in recent years (Ali, 2011; Krebs, Lindquist, Berzofsky, Shook-Sa, & Peterson, 2016). Resources designed to address the problem exist, but there is evidence that they are underutilized by survivors (Campbell, 2008). The current study used grounded theory to explore how sexual assault survivors make decisions about helpseeking. In-depth interviews were conducted with 14 college sexual assault survivors to develop a theoretical model for their decision-making process. The resulting model, Deciding Where to Turn, suggests that survivors engage in three key decision points: determining if there is a problem related to the sexual assault (Do I Need Help), considering options (What Can I Do), and weighing the consequences of these options (What Will I Do). This process results in one of four behavioral choices: cope on one's own, seek support from friends/family, seek support from formal resources, or covert helpseeking, where needs are met without disclosure. Deciding Where to Turn contributes to the literature by providing a framework for understanding helpseeking decisions after sexual assault, highlighting the need to match reactions to survivor perceptions. The concept of covert helpseeking in particular adds to the way researchers and practitioners think about helpseeking. Research and practice implications are discussed. © Society for Community Research and Action 2017.

Hip resurfacing in patients under thirty years old: an attractive option for young and active patients.

PubMed

Krantz, Nicolas; Miletic, Bruno; Migaud, Henri; Girard, Julien

2012-09-01

Metal-on-metal hip resurfacing is offered as an alternative to traditional hip arthroplasty for young, active adults with advanced osteoarthritis. The concept of hip resurfacing is considered very attractive for this specific population (hard-on-hard bearing component with a large femoral head limiting the risk of dislocation, and allowing femoral bone stock preservation). A prospective clinical trial was designed to investigate the outcome of hip resurfacing in young patients (under 30 years old). We studied 24 hips in 22 patients. Mean age at operation was 24.9 years (range 17.1-29.9). No patient was lost to follow-up. There was no revision at average follow-up of 50.6 months (44-59). Mean UCLA activity score improved from 5.5 (1-9) pre-operatively to 7.6 (1-10) postoperatively (p < 0.001). Mean Harris hip score increased from 43.9 (19-67) to 89.3 (55-100) (p < 0.001). Radiological analysis discerned no osteolysis and no implant migration. The absence of short-term complications, such as mechanical failure or dislocation, is encouraging and leads us to think that mid-term results will be satisfactory. Moreover, the specific advantages of hip resurfacing (bone stock preservation, excellent stability, low risk of dislocation, large-diameter head) make the procedure a very attractive option for young subjects.

Broad perspectives in radar for ocean measurements

NASA Technical Reports Server (NTRS)

Jain, A.

1978-01-01

The various active radar implementation options available for the measurement functions of interest for the SEASAT follow-on missions were evaluated. These functions include surface feature imaging, surface pressure and vertical profile, atmospheric sounding, surface backscatter and wind speed determination, surface current location, wavelength spectra, sea surface topography, and ice/snow thickness. Some concepts for the Synthetic Aperture Imaging Radar were examined that may be useful in the design and selection of the implementation options for these missions. The applicability of these instruments for the VOIR mission was also kept under consideration.

Valuing natural gas power generation assets in the new competitive marketplace

NASA Astrophysics Data System (ADS)

Hsu, Michael Chun-Wei

1999-10-01

The profitability of natural gas fired power plants depends critically on the spread between electricity and natural gas prices. The price levels of these two energy commodities are the key uncertain variables in determining the operating margin and therefore the value of a power plant. The owner of a generation unit has the decision of dispatching the plant only when profit margins are positive. This operating flexibility is a real option with real value. In this dissertation I introduce the spark spread call options and illustrate how such paper contracts replicate the uncertain payoff space facing power asset owners and, therefore, how the financial options framework can be applied in estimating the value of natural gas generation plants. The intrinsic value of gas power plants is approximated as the sum of a series of spark spread call options with succeeding maturity dates. The Black-Scholes spread option pricing model, with volatility and correlation term structure adjustments, is utilized to price the spark spread options. Sensitivity analysis is also performed on the BS spread option formulation to compare different asset types. In addition I explore the potential of using compound and compound-exchange option concepts to evaluate, respectively, the benefits of delaying investment in new generation and in repowering existing antiquated units. The compound option designates an option on top of another option. In this case the series of spark spread call options is the 'underlying' option while the option to delay new investments is the 'overlying.' The compound-exchange option characterizes the opportunity to 'exchange' the old power plant, with its series of spark spread call options, for a set of new spark spread call options that comes with the new generation unit. The strike price of the compound-exchange option is the repowering capital investment and typically includes the purchase of new steam generators and combustion turbines, as well as other facility upgrades. The pricing results using the proposed repowering option approach is compared to the sale prices from recent power plant auctions. Sensitivity of the repowering option model is also examined and the critical parameters al parameters identified.

Switzerland and Its Educational System: From Babylon zu Multiculturalism.

ERIC Educational Resources Information Center

Allemann-Ghionda, Cristina

1994-01-01

Discusses the paradoxes of the current policies toward multiculturalism and multilingualism in Switzerland. Asserts that policy perspectives lean toward diversity rather than assimilation. Proposes options for an educational concept in a linguistically and culturally plural Switzerland, embedded in Europe. (CFR)

Sandy Hook : alternative access concept plan and vehicle replacement study

DOT National Transportation Integrated Search

2009-06-01

This study addresses two critical issues of concern to the Sandy Hook Unit of Gateway National : Recreational Area: (1) options for alternative access to Sandy Hook during peak summer season, : particularly when the park is closed to private vehicles...

Would you rather take orders from Kirk or Spock? The relation between rational thinking and intelligence.

PubMed

Sternberg, R J

1993-10-01

This article considers the relation between rationality and intelligence. The article is divided into three main parts: In the first, I consider the concept of rationality and conclude that rational thinking is a part of intelligence, but not a major part. In the second, I consider Stanovich's concept of dysrationalia, and propose that an alternative concept, practical intelligence (or the lack thereof), may better accomplish the goals that Stanovich wishes to achieve with his concept. Finally, I draw some conclusions.

Towards resiliency with micro-grids: Portfolio optimization and investment under uncertainty

NASA Astrophysics Data System (ADS)

Gharieh, Kaveh

Energy security and sustained supply of power are critical for community welfare and economic growth. In the face of the increased frequency and intensity of extreme weather conditions which can result in power grid outage, the value of micro-grids to improve the communities' power reliability and resiliency is becoming more important. Micro-grids capability to operate in islanded mode in stressed-out conditions, dramatically decreases the economic loss of critical infrastructure in power shortage occasions. More wide-spread participation of micro-grids in the wholesale energy market in near future, makes the development of new investment models necessary. However, market and price risks in short term and long term along with risk factors' impacts shall be taken into consideration in development of new investment models. This work proposes a set of models and tools to address different problems associated with micro-grid assets including optimal portfolio selection, investment and financing in both community and a sample critical infrastructure (i.e. wastewater treatment plant) levels. The models account for short-term operational volatilities and long-term market uncertainties. A number of analytical methodologies and financial concepts have been adopted to develop the aforementioned models as follows. (1) Capital budgeting planning and portfolio optimization models with Monte Carlo stochastic scenario generation are applied to derive the optimal investment decision for a portfolio of micro-grid assets considering risk factors and multiple sources of uncertainties. (2) Real Option theory, Monte Carlo simulation and stochastic optimization techniques are applied to obtain optimal modularized investment decisions for hydrogen tri-generation systems in wastewater treatment facilities, considering multiple sources of uncertainty. (3) Public Private Partnership (PPP) financing concept coupled with investment horizon approach are applied to estimate public and private parties' revenue shares from a community-level micro-grid project over the course of assets' lifetime considering their optimal operation under uncertainty.

Evaluating holistic environmental consequences of brownfield management options using consequential life cycle assessment for different perspectives.

PubMed

Lesage, Pascal; Deschênes, Louise; Samson, Réjean

2007-08-01

Brownfields are abandoned, idled, or underused sites whose reuse necessitates some sort of intervention. These sites are largely urban and are frequently contaminated. Brownfield management options can be associated with three types of environmental consequences: those resulting from changes in the site's environmental quality (primary impacts); those resulting from the actual intervention stage (secondary impacts); and, if the vocation of the site changes, those resulting from effects on regional land use (tertiary impacts). Different stakeholders and decision-making contexts will place a different importance on each of these types of impacts. This article proposes a framework for comparing brownfield management options in regard to these three types of environmental impacts and for interpreting these results from different perspectives. The assessment framework is based on consequential life cycle assessment (LCA), which is shown to provide environmental information on the three types of impacts. The results for a case study are presented, where a "rehabilitation" option allowing residential redevelopment is compared to an "exposure minimization" option not resulting in the site being reused. Calculated primary and tertiary impacts are favorable to the rehabilitation option, whereas secondary impacts are favorable to the exposure minimization option. A ternary diagram presents the favorable option for different stereotypical perspectives. Tertiary impacts are much greater than secondary impacts, and consequently all perspectives that consider tertiary impacts favor rehabilitation. The perspective that considers primary and secondary impacts receives conflicting information. The ternary diagram, showing results for all perspectives, could possibly be useful for consensus-building among stakeholders.

Evaluating Holistic Environmental Consequences of Brownfield Management Options Using Consequential Life Cycle Assessment for Different Perspectives

NASA Astrophysics Data System (ADS)

Lesage, Pascal; Deschênes, Louise; Samson, Réjean

2007-08-01

Brownfields are abandoned, idled, or underused sites whose reuse necessitates some sort of intervention. These sites are largely urban and are frequently contaminated. Brownfield management options can be associated with three types of environmental consequences: those resulting from changes in the site’s environmental quality (primary impacts); those resulting from the actual intervention stage (secondary impacts); and, if the vocation of the site changes, those resulting from effects on regional land use (tertiary impacts). Different stakeholders and decision-making contexts will place a different importance on each of these types of impacts. This article proposes a framework for comparing brownfield management options in regard to these three types of environmental impacts and for interpreting these results from different perspectives. The assessment framework is based on consequential life cycle assessment (LCA), which is shown to provide environmental information on the three types of impacts. The results for a case study are presented, where a “rehabilitation” option allowing residential redevelopment is compared to an “exposure minimization” option not resulting in the site being reused. Calculated primary and tertiary impacts are favorable to the rehabilitation option, whereas secondary impacts are favorable to the exposure minimization option. A ternary diagram presents the favorable option for different stereotypical perspectives. Tertiary impacts are much greater than secondary impacts, and consequently all perspectives that consider tertiary impacts favor rehabilitation. The perspective that considers primary and secondary impacts receives conflicting information. The ternary diagram, showing results for all perspectives, could possibly be useful for consensus-building among stakeholders.

Understanding Participatory Action Research: A Qualitative Research Methodology Option

ERIC Educational Resources Information Center

MacDonald, Cathy

2012-01-01

Participatory Action Research (PAR) is a qualitative research methodology option that requires further understanding and consideration. PAR is considered democratic, equitable, liberating, and life-enhancing qualitative inquiry that remains distinct from other qualitative methodologies (Kach & Kralik, 2006). Using PAR, qualitative features of an…

Status of the Space Station environmental control and life support system design concept

NASA Technical Reports Server (NTRS)

Ray, C. D.; Humphries, W. R.

1986-01-01

The current status of the Space Station (SS) environmental control and life support system (ECLSS) design is outlined. The concept has been defined at the subsystem level. Data supporting these definitions are provided which identify general configuratioons for all modules. Requirements, guidelines and assumptions used in generating these configurations are detailed. The basic 2 US module 'core' Space Station is addressed along with system synergism issues and early man-tended and future growth considerations. Along with these basic studies, also addressed here are options related to variation in the 'core' module makeup and more austere Station concepts such as commonality, automation and design to cost.

Shungnak Energy Configuration Options.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosewater, David Martin; Eddy, John P.

Power systems in rural Alaska villages face a unique combination of challenges that can increase the cost of energy and lowers energy supply reliability. In the case of the remote village of Shungnak, diesel and heating fuel is either shipped in by barge or flown in by aircraft. This report presents a technical analysis of several energy infrastructure upgrade and modification options to reduce the amount of fuel consumed by the community of Shungnak. Reducing fuel usage saves money and makes the village more resilient to disruptions in fuel supply. The analysis considers demand side options, such as energy efficiency,more » alongside the installation of wind and solar power generation options. Some novel approaches are also considered including battery energy storage and the use of electrical home heating stoves powered by renewable generation that would otherwise be spilled and wasted. This report concludes with specific recommendations for Shungnak based on economic factors, and fuel price sensitivity. General conclusions are also included to support future work analyzing similar energy challenges in remote arctic regions.« less

Diesel plant retrofitting options to enhance decentralized electricity supply in Indonesia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baring-Gould, E I; Barley, C D; Drouilhet, S

1997-09-01

Over the last 20 years, the government of Indonesia has undertaken an extensive program to provide electricity to the population of that country. The electrification of rural areas has been partially achieved through the use of isolated diesel systems, which account for about 20% of the country`s generated electricity. Due to many factors related to inefficient power production with diesels, the National Renewable Energy Laboratory, in conjunction with PLN, the Indonesian national utility, Community Power Corporation, and Idaho Power Company, analyzed options for retrofitting existing diesel power systems. This study considered the use of different combinations of advanced diesel control,more » the addition of wind generators, photovoltaics and batteries to reduce the systems of overall cost and fuel consumption. This analysis resulted in a general methodology for retrofitting diesel power systems. This paper discusses five different retrofitting options to improve the performance of diesel power systems. The systems considered in the Indonesian analysis are cited as examples for the options discussed.« less

Energy efficiency business options for industrial end users in Latin American competitive energy markets: The case of Colombia

NASA Astrophysics Data System (ADS)

Botero, Sergio

2002-01-01

Energy markets today in Latin America and worldwide are being restructured from monopolies, either state-owned or privately-owned, to be more openly competitive and incorporate more participation from the private sector. Thus, the schemes that were formerly developed to foster end use energy efficiency are no longer applicable because they were based on mandatory regulations made with political decisions, without sufficiently considering economic feasibility. A consensus exists that the only way energy efficiency could survive in this new paradigm is by being market oriented, giving better services, and additional options to users. However; there is very little information on what end users prefer, and which options would most satisfy customers. Using Colombia as a case study, this research determines and categorizes the energy efficiency business options for large energy end users that can freely participate in the competitive energy market. The energy efficiency market is understood as a market of services aiming to increase efficiency in energy use. These services can be grouped into seven business options. A survey, following the descriptive method, was sent to energy end users in order to determine their preferences for specific energy efficiency business options, as well as the decision-making criteria taken into account for such options. This data was categorized in ten industry groups. As a conclusion, energy efficiency providers should adapt not only to the economic activity or processes of each customer, but also to the potential business options. It was also found that not all industries consider performance contracting as their most preferred option, as a matter of fact, some industries show much higher preference for conventional business options. Among end users, the divergence in option preferences contrasted with the convergence in decision-making criteria. The decision-making criteria "cost-benefit ratio" overwhelmed all other criterion. End users appear to chose a specific energy efficiency option based mostly on obtaining better economic returns, giving low consideration to other criterion that feature differences among the energy efficiency options.

Fission Surface Power Technology Development Testing at NASA's Early Flight Fission Test Facility

NASA Technical Reports Server (NTRS)

Houts. Michael G.

2009-01-01

Fission surface power (FSP) systems could be used to provide power anytime, anywhere on the surface of the Moon or Mars. FSP systems could be used at polar locations, at locations away from the poles, or in permanently shaded regions, with excellent performance at all sites. A potential reference 40 kWe option has been devised that is cost-competitive with alternatives while providing more power for less mass anywhere on the lunar surface. The reference FSP system (FSPS) is also readily extensible for use on Mars. At Mars the system would be capable of operating through global dust storms and providing year-round power at any Martian latitude. Under the NASA Exploration Technology Development Program (ETDP), NASA and the Department of Energy (DOE) have begun technology development on Fission Surface Power (FSP). The primary customer for this technology is the NASA Constellation Program which is responsible for the development of surface systems to support human exploration on the moon and Mars. The objectives of the FSP technology project are: 1) Develop FSP concepts that meet expected surface power requirements at reasonable cost with added benefits over other options. 2) Establish a hardware-based technical foundation for FSP design concepts and reduce overall development risk. 3) Reduce the cost uncertainties for FSP and establish greater credibility for flight system cost estimates. 4) Generate the key products to allow Agency decision-makers to consider FSP as a viable option for flight development. To be mass efficient, FSP systems must operate at higher coolant temperatures and use different types of power conversion than typical terrestrial systems. The primary reason is the difficulty in rejecting excess heat to space. Although many options exist, NASA s current reference FSP system uses a fast spectrum, pumped-NaK cooled reactor coupled to a Stirling power conversion subsystem. The reference system uses technology with significant terrestrial heritage while still providing excellent performance on the surface of the moon or Mars. Recent testing at NASA s Early Flight Fission Test Facility (EFF-TF) has helped assess the viability of the reference FSP system, and has helped evaluate methods for system integration. In June, 2009, a representative pumped NaK loop (provided by Marshall Space Flight Center) was coupled to a Stirling power converter (provided by Glenn Research Center) and tested at various conditions representative of those that would be seen during actual FSP system operation. In all areas, performance of the integrated system exceeded project goals. High-temperature NaK pump testing has also been performed at the EFF-TF, as has testing of methods for providing long-duration NaK purity.

The Europa Clipper mission concept

NASA Astrophysics Data System (ADS)

Pappalardo, Robert; Lopes, Rosaly

Jupiter's moon Europa may be a habitable world. Galileo spacecraft data suggest that an ocean most likely exists beneath Europa’s icy surface and that the “ingredients” necessary for life (liquid water, chemistry, and energy) could be present within this ocean today. Because of the potential for revolutionizing our understanding of life in the solar system, future exploration of Europa has been deemed an extremely high priority for planetary science. A NASA-appointed Science Definition Team (SDT), working closely with a technical team from the Jet Propulsion Laboratory (JPL) and the Applied Physics Laboratory (APL), recently considered options for a future strategic mission to Europa, with the stated science goal: Explore Europa to investigate its habitability. The group considered several mission options, which were fully technically developed, then costed and reviewed by technical review boards and planetary science community groups. There was strong convergence on a favored architecture consisting of a spacecraft in Jupiter orbit making many close flybys of Europa, concentrating on remote sensing to explore the moon. Innovative mission design would use gravitational perturbations of the spacecraft trajectory to permit flybys at a wide variety of latitudes and longitudes, enabling globally distributed regional coverage of the moon’s surface, with nominally 45 close flybys at altitudes from 25 to 100 km. We will present the science and reconnaissance goals and objectives, a mission design overview, and the notional spacecraft for this concept, which has become known as the Europa Clipper. The Europa Clipper concept provides a cost-efficient means to explore Europa and investigate its habitability, through understanding the satellite’s ice and ocean, composition, and geology. The set of investigations derived from these science objectives traces to a notional payload for science, consisting of: Ice Penetrating Radar (for sounding of ice-water interfaces within and beneath the ice shell), Topographical Imager (for stereo imaging of the surface), ShortWave Infrared Spectrometer (for surface composition), Neutral Mass Spectrometer (for atmospheric composition), Magnetometer and Langmuir Probes (for inferring the satellite’s induction field to characterize an ocean), and Gravity Science (to confirm an ocean).The mission would also include the capability to perform reconnaissance for a future lander, with the Reconnaissance goal: Characterize safe and scientifically compelling sites for a future lander mission to Europa. To accomplish these reconnaissance objectives and the investigations that flow from them, principally to address issues of landing site safety, two additional instruments would be included in the notional payload: a Reconnaissance Camera (for high-resolution imaging) and a Thermal Imager (to characterize the surface through its thermal properties). These instruments, in tandem with the notional payload for science, could assess the science value of potential landing sites. This notional payload serves as a proof-of-concept for the Europa Clipper during its formulation stage. The actual payload would be chosen through a NASA Announcement of Opportunity. If NASA were to proceed with the mission, it could be possible to launch early in the coming decade, on an Atlas V or the Space Launch System (SLS).

Generation of optimum vertical profiles for an advanced flight management system

NASA Technical Reports Server (NTRS)

Sorensen, J. A.; Waters, M. H.

1981-01-01

Algorithms for generating minimum fuel or minimum cost vertical profiles are derived and examined. The option for fixing the time of flight is included in the concepts developed. These algorithms form the basis for the design of an advanced on-board flight management system. The variations in the optimum vertical profiles (resulting from these concepts) due to variations in wind, takeoff mass, and range-to-destination are presented. Fuel savings due to optimum climb, free cruise altitude, and absorbing delays enroute are examined.

Design of an airborne lidar for stratospheric aerosol measurements

NASA Technical Reports Server (NTRS)

Evans, W. E.

1977-01-01

A modular, multiple-telescope receiving concept is developed to gain a relatively large receiver collection aperture without requiring extensive modifications to the aircraft. This concept, together with the choice of a specific photodetector, signal processing, and data recording system capable of maintaining approximately 1% precision over the required large signal amplitude range, is found to be common to all of the options. It is recommended that development of the lidar begin by more detailed definition of solutions to these important common signal detection and recording problems.

Scleral Lenses in the Management of Corneal Irregularity and Ocular Surface Disease.

PubMed

Shorter, Ellen; Harthan, Jennifer; Nau, Cherie B; Nau, Amy; Barr, Joseph T; Hodge, David O; Schornack, Muriel M

2017-09-29

To describe current practice patterns regarding the use of scleral lens therapy in the management of corneal irregularity and ocular surface disease among eye care providers who fit scleral lenses. The Scleral Lenses in Current Ophthalmic Practice: an Evaluation (SCOPE) study group conducted an electronic survey of eye care providers from January 15 to March 31, 2015. Respondents ranked management options for corneal irregularity in the order in which they would generally consider their use. Respondents also ranked options for the management of ocular surface disease in the order in which they would use each of the treatments. Results for each option were analyzed as percentage first-place ranking; percentage first-, second-, or third-place ranking; and mean rank score. Survey responses were obtained from 723 providers who had fit 5 or more scleral lenses. Of these respondents, 629 ranked options for management of corneal irregularity and 612 ranked options for management of ocular surface disease. Corneal rigid gas-permeable lenses were the first option for management of corneal irregularity for 44% of respondents, and scleral lenses were the first option for 34% of respondents. Lubricant drops were the first therapeutic recommendation for ocular surface disease for 84% of respondents, and scleral lenses were ranked first by 6% of respondents. Scleral lenses rank second only to corneal rigid gas-permeable lenses for management of corneal irregularity. Scleral lenses are generally considered after other medical intervention and before surgery for the management of ocular surface disease.

A Basic Study on Optimal Investment of Power Sources Considering Environmental Measures

NASA Astrophysics Data System (ADS)

Kato, Moritoshi; Zhou, Yicheng

This paper focuses on economic evaluations of a coal-fired thermal power station with a carbon dioxide capture and storage unit (CCS) by which an existing coal-fired thermal power station (COAL) is replaced. Decision makers decide to construct CCS considering both of contrary elements; one is waiting more favorable conditions such as a higher value of carbon credits which CCS has, another is reducing opportunity costs due to delay of construction of CCS. New methods using a real option approach are proposed. Firstly we calculate an economic value of CCS as an American coal option with dividend considering carbon emission costs of COAL as opportunity costs. Secondly we evaluate construction time of CCS using binominal decision tree taking into account the options. Numerical examples show that a real option value of CCS is from 28% to 44% of sales revenue, which are higher than net present values due to a value on waiting for more favorable conditions. And they also show that an earlier construction is exercised and the value becomes lower, the more challenging the benchmark of carbon emissions is or the higher the change rate of maintenance cost of COAL becomes. An effect of a lifetime of power stations is also analyzed.

Fertility preservation options in breast cancer patients.

PubMed

Kasum, Miro; von Wolff, Michael; Franulić, Daniela; Čehić, Ermin; Klepac-Pulanić, Tajana; Orešković, Slavko; Juras, Josip

2015-01-01

The purpose of this review is to analyse current options for fertility preservation in young women with breast cancer (BC). Considering an increasing number of BC survivors, owing to improvements in cancer treatment and delaying of childbearing, fertility preservation appears to be an important issue. Current fertility preservation options in BC survivors range from well-established standard techniques to experimental or investigational interventions. Among the standard options, random-start ovarian stimulation protocol represents a new technique, which significantly decreases the total time of the in vitro fertilisation cycle. However, in patients with oestrogen-sensitive tumours, stimulation protocols using aromatase inhibitors are currently preferred over tamoxifen regimens. Cryopreservation of embryos and oocytes are nowadays deemed the most successful techniques for fertility preservation in BC patients. GnRH agonists during chemotherapy represent an experimental method for fertility preservation due to conflicting long-term outcome results regarding its safety and efficacy. Cryopreservation of ovarian tissue, in vitro maturation of immature oocytes and other strategies are considered experimental and should only be offered within the context of a clinical trial. An early pretreatment referral to reproductive endocrinologists and oncologists should be suggested to young BC women at risk of infertility, concerning the risks and benefits of fertility preservation options.

Pressurization, Pneumatic, and Vent Subsystems of the X-34 Main Propulsion System

NASA Technical Reports Server (NTRS)

Hedayat, A.; Steadman, T. E.; Brown, T. M.; Knight, K. C.; White, C. E., Jr.; Champion, R. H., Jr.

1998-01-01

In pressurization systems, regulators and orifices are use to control the flow of the pressurant. For the X-34 Main Propulsion System, three pressurization subsystem design configuration options were considered. In the first option, regulators were used while in the other options, orifices were considered. In each design option, the vent/relief system must be capable of relieving the pressurant flow without allowing the tank pressure to rise above proof, therefore, impacts on the propellant tank vent system were investigated and a trade study of the pressurization system was conducted. The analysis indicated that design option using regulators poses least risk. Then, a detailed transient thermal/fluid analysis of the recommended pressurization system was performed. Helium usage, thermodynamic conditions, and overpressurization of each propellant tank were evaluated. The pneumatic and purge subsystem is used for pneumatic valve actuation, Inter-Propellant Seal purges, Engine Spin Start, and engine purges at the required interface pressures, A transient analysis of the pneumatic and purge subsystem provided helium usage and flow rates to Inter-Propellant Seal and engine interfaces. Fill analysis of the helium bottles of pressurization and pneumatic subsystems during ground operation was performed. The required fill time and the stored

78 FR 68494 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-14

... Exchange does not wish to remove the concept of the Select Symbols (and corresponding fees structure) from... volume in the Removed Symbols. Finally, these fees for the Removed Symbols will be the same as for all...

Feasibility study of the Boeing Small Research Module (BSRM) concept

NASA Technical Reports Server (NTRS)

1975-01-01

The design, capabilities, and subsystem options are described for the Boeing Small Research Module (BSRM). Specific scientific missions are defined and the BSRM capability to support these missions is discussed. Launch vehicle integration requirements and spacecraft operational features are also presented.

Centralized vs decentralized options for an European Data Relay Satellite system

NASA Astrophysics Data System (ADS)

Saint Aubert, S.; Hervieux, M.; Perbos, J. L.; Saggese, E.; Soprano, C.

1985-10-01

The European Data Relay Satellite (DRS) is now being planned to support future European missions in the nineties and in particular the various elements of the in-orbit infrastructure. Studies are being conducted to investigate the usefulness of the relay system as well as to provide the basis for issuing technical specifications for a development and launch in 1993. This paper presents the results of a study issued by ESA on possible options for a DRS System, concentrating on the comparison between a centralized and a decentralized data distribution concept. After recalling the space programs foreseen in Europe, the paper discusses the architecture and design of the various elements of the System: space segment, DRS ground segment, and user ground segment for different options of data dissemination.

Centralized vs decentralized options for a european data relay satellite system

NASA Astrophysics Data System (ADS)

Aubert, Ph. Saint; Hervieux, M.; Perbos, J. L.; Saggese, E.; Soprano, C.

The European Data Relay Satellite (DRS) is now being planned to support future European missions in the nineties and in particular the various elements of the in-orbit infrastructure. Studies are being conducted to investigate the usefulness of the Relay System as well as to provide the basis for issuing technical specifications for a development and launch in 1993. This paper presents the results of a study issued by ESA on possible options for a DRS System, concentrating on the comparison between a centralized and a decentralized data distribution concept. After recalling the space programmes foreseen in Europe, the paper discusses the architecture and design of the various elements of the System: space segment, DRS ground segment and user ground segment for different options of data dissemination.

Nonlethal weapons as force options for the Army

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alexander, J.B.

This paper suggests that future challenges to US national security will be very different from those previously experienced. In a number of foreseeable circumstances, conventional military force will be inappropriate. The National Command Authority, and other appropriate levels of command, need expanded options available to meet threats for which the application of massive lethal force is counterproductive or inadvisable. It is proposed that nonlethal concepts be developed that provide additional options for military leaders and politicians. Included in this initiative should be exploration of policy, strategy, doctrine, and training issues as well as the development of selected technologies and weapons.more » In addition, civilian law enforcement agencies have similar requirements for less-than-lethal systems. This may be an excellent example for a joint technology development venture.« less

The Concept of Energy Without Heat or Work.

ERIC Educational Resources Information Center

Kemp, H. R.

1984-01-01

Develops the concept of energy without using the terms heat and work. Topic areas considered include mechanical energy, internal energy, total energy, energy conservation, applications of energy conservation, kinds of internal energy, and restrictions on energy changes. Implications for teaching the energy concept are also considered. (JN)

The Opinions of GP's Patients About Suicide, Assisted Suicide, Euthanasia, and Suicide Prevention: An Italian Survey.

PubMed

Poma, Stefano Zanone; Vicentini, Silvia; Siviero, Francesca; Grossi, Antonello; Toniolo, Emanuele; Baldo, Vincenzo; De Leo, Diego

2015-08-01

A survey about opinions on end-of-life issues of a population represented by 1,171 people in the waiting room of general practitioners' surgeries was conducted in a province of northern Italy. Most subjects did not consider suicide as a reasonable option even in cases of a serious and incurable disease. Moreover, subjects did not consider euthanasia as a possible option either; however, they did express an opposite attitude when considering euthanasia in a third-person perspective. People with a personal history of suicidal behavior appear to present as a different population, overall expressing more open attitudes. © 2014 The American Association of Suicidology.

Analysis and Down Select of Flow Passages for Thermal Hydraulic Testing of a SNAP Derived Reactor

NASA Technical Reports Server (NTRS)

Godfroy, T. J.; Sadasivan, P.; Masterson, S.

2007-01-01

As past of the Vision for Space Exploration, man will return to the moon. To enable safe and productive time on the lunar surface will require adequate power resources. To provide the needed power and to give mission planners all landing site possibilities, including a permanently dark crater, a nuclear reactor provides the most options. Designed to be l00kWt providing approx. 25kWe this power plants would be very effective in delivering dependable, site non-specific power to crews or robotic missions on the lunar surface. An affordable reference reactor based upon the successful SNAP program of the 1960's and early 1970's has been designed by Los Alamos National Laboratory that will meet such a requirement. Considering current funding, environmental, and schedule limitations this lunar surface power reactor will be tested using non-nuclear simulators to simulate the heat from fission reactions. Currently a 25kWe surface power SNAP derivative reactor is in the early process of design and testing with collaboration between Los Alamos National Laboratory, Idaho National Laboratory, Glenn Research Center, Marshall Space Flight Center, and Sandia National Laboratory to ensure that this new design is affordable and can be tested using non-nuclear methods as have proven so effective in the past. This paper will discuss the study and down selection of a flow passage concept for a approx. 25kWe lunar surface power reactor. Several different flow passages designs were evaluated using computational fluid dynamics to determine pressure drop and a structural assessment to consider thermal and stress of the passage walls. The reactor design basis conditions are discussed followed by passage problem setup and results for each concept. A recommendation for passage design is made with rationale for selection.

Thermal Performance of Orion Active Thermal Control System With Seven-Panel Reduced-Curvature Radiator

NASA Technical Reports Server (NTRS)

Wang, Xiao-Yen J.; Yuko, James R.

2010-01-01

The active thermal control system (ATCS) of the crew exploration vehicle (Orion) uses radiator panels with fluid loops as the primary system to reject heat from spacecraft. The Lockheed Martin (LM) baseline Orion ATCS uses eight-panel radiator coated with silver Teflon coating (STC) for International Space Station (ISS) missions, and uses seven-panel radiator coated with AZ 93 white paint for lunar missions. As an option to increase the radiator area with minimal impact on other component locations and interfaces, the reduced-curvature (RC) radiator concept was introduced and investigated here for the thermal perspective. Each RC radiator panel has 15 percent more area than each Lockheed Martin (LM) baseline radiator panel. The objective was to determine if the RC seven-panel radiator concept could be used in the ATCS for both ISS and lunar missions. Three radiator configurations the LM baseline, an RC seven-panel radiator with STC, and an RC seven-panel radiator with AZ 93 coating were considered in the ATCS for ISS missions. Two radiator configurations the LM baseline and an RC seven-panel radiator with AZ 93 coating were considered in the ATCS for lunar missions. A Simulink/MATLAB model of the ATCS was used to compute the ATCS performance. Some major hot phases on the thermal timeline were selected because of concern about the large amount of water sublimated for thermal topping. It was concluded that an ATCS with an RC seven-panel radiator could be used for both ISS and lunar missions, but with two different coatings STC for ISS missions and AZ 93 for lunar missions to provide performance similar to or better than that of the LM baseline ATCS.

Viral Oncolysis — Can Insights from Measles Be Transferred to Canine Distemper Virus?

PubMed Central

Lapp, Stefanie; Pfankuche, Vanessa M.; Baumgärtner, Wolfgang; Puff, Christina

2014-01-01

Neoplastic diseases represent one of the most common causes of death among humans and animals. Currently available and applied therapeutic options often remain insufficient and unsatisfactory, therefore new and innovative strategies and approaches are highly needed. Periodically, oncolytic viruses have been in the center of interest since the first anecdotal description of their potential usefulness as an anti-tumor treatment concept. Though first reports referred to an incidental measles virus infection causing tumor regression in a patient suffering from lymphoma several decades ago, no final treatment concept has been developed since then. However, numerous viruses, such as herpes-, adeno- and paramyxoviruses, have been investigated, characterized, and modified with the aim to generate a new anti-cancer treatment option. Among the different viruses, measles virus still represents a highly interesting candidate for such an approach. Numerous different tumors of humans including malignant lymphoma, lung and colorectal adenocarcinoma, mesothelioma, and ovarian cancer, have been studied in vitro and in vivo as potential targets. Moreover, several concepts using different virus preparations are now in clinical trials in humans and may proceed to a new treatment option. Surprisingly, only few studies have investigated viral oncolysis in veterinary medicine. The close relationship between measles virus (MV) and canine distemper virus (CDV), both are morbilliviruses, and the fact that numerous tumors in dogs exhibit similarities to their human counterpart, indicates that both the virus and species dog represent a highly interesting translational model for future research in viral oncolysis. Several recent studies support such an assumption. It is therefore the aim of the present communication to outline the mechanisms of morbillivirus-mediated oncolysis and to stimulate further research in this potentially expanding field of viral oncolysis in a highly suitable translational animal model for the benefit of humans and dogs. PMID:24921409

Los Alamos RAGE Simulations of the HAIV Mission Concept

NASA Technical Reports Server (NTRS)

Weaver, Robert P.; Barbee, Brent W.; Wie, Bong; Zimmerman, Ben

2015-01-01

The mitigation of potentially hazardous objects (PHOs) can be accomplished by a variety of methods including kinetic impactors, gravity tractors and several nuclear explosion options. Depending on the available lead time prior to Earth impact, non- nuclear options can be very effective at altering a PHOs orbit. However if the warning time is short nuclear options are generally deemed most effective at mitigating the hazard. The NIAC mission concept for a nuclear mission has been presented at several meetings, including the last PDC (2013).We use the adaptive mesh hydrocode RAGE to perform detailed simulations of this Hypervelocity Asteroid Intercept Vehicle (HAIV) mission concept. We use the RAGE code to simulate the crater formation by the kinetic impactor as well as the explosion and energy coupling from the follower nuclear explosive device (NED) timed to detonate below the original surface to enhance the energy coupling. The RAGE code has been well validated for a wide variety of applications. A parametric study will be shown of the energy and momentum transfer to the target 100 m diameter object: 1) the HAIV mission as planned; 2) a surface explosion and 3) a subsurface (contained) explosion; both 2) and 3) use the same source energy as 1).Preliminary RAGE simulations show that the kinetic impactor will carve out a surface crater on the object and the subsequent NED explosion at the bottom of the crater transfers energy and momentum to the target effectively moving it off its Earth crossing orbit. Figure 1 shows the initial (simplified) RAGE 2D setup geometry for this study. Figure 2 shows the crater created by the kinetic impactor and Figure 3 shows the time sequence of the energy transfer to the target by the NED.

Exploring patient values in medical decision making: a qualitative study.

PubMed

Lee, Yew Kong; Low, Wah Yun; Ng, Chirk Jenn

2013-01-01

Patient decisions are influenced by their personal values. However, there is a lack of clarity and attention on the concept of patient values in the clinical context despite clear emphasis on patient values in evidence-based medicine and shared decision making. The aim of the study was to explore the concept of patient values in the context of making decisions about insulin initiation among people with type 2 diabetes. We conducted individual in-depth interviews with people with type 2 diabetes who were making decisions about insulin treatment. Participants were selected purposively to achieve maximum variation. A semi-structured topic guide was used to guide the interviews which were audio-recorded and analysed using a thematic approach. We interviewed 21 participants between January 2011 and March 2012. The age range of participants was 28-67 years old. Our sample comprised 9 women and 12 men. Three main themes, 'treatment-specific values', 'life goals and philosophies', and 'personal and social background', emerged from the analysis. The patients reported a variety of insulin-specific values, which were negative and/or positive beliefs about insulin. They framed insulin according to their priorities and philosophies in life. Patients' decisions were influenced by sociocultural (e.g. religious background) and personal backgrounds (e.g. family situations). This study highlighted the need for expanding the current concept of patient values in medical decision making. Clinicians should address more than just values related to treatment options. Patient values should include patients' priorities, life philosophy and their background. Current decision support tools, such as patient decision aids, should consider these new dimensions when clarifying patient values.

Programmed Sports Therapy (PST) in People with Haemophilia (PwH) "Sports Therapy Model for Rare Diseases".

PubMed

Hilberg, Thomas

2018-03-05

Sports and exercise therapy becomes more and more integrated in the treatment plan of different diseases. Although the benefits of this therapy are of high quality evidence, e.g. in cardiovascular diseases, no concepts of sports therapy are available as a treatment option for rare diseases.During the last eighteen years, we analyzed the situation as well as necessity, and developed a model, contents and the concept of the "Programmed Sports Therapy (PST)" for the treatment of PwH (people with haemophilia) as our model of rare disease. Many studies have shown that motoric skills are depressed in PwH, and that this gap to healthy people increases during age. The only way to reduce this progression is an appropriate therapy, adapted to the necessities of PwH. In haemophilia, in particular, physio- and sports therapy treatments should go hand in hand, the first in the acute phase after bleeding, the second later, after the acute phase has finished. One model, which considers all the different challenges, can be the cogwheel model presented here. Since haemophilia is a rare disease, new training concepts are necessary because classical group therapies are often impossible. PST based on the combination of sports therapy camps together with a supervised autonomous home training helps to directly bring the training to the trainee, in order to enhance key competences and improve the individual situation in PwH, and perhaps in patients with other rare diseases.The experience and scientific data substantiate the success of "Programmed Sports Therapy (PST)" and even this can be a model for other rare diseases.

Core Design Characteristics of the Fluoride Salt-Cooled High Temperature Demonstration Reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brown, Nicholas R; Qualls, A L; Betzler, Benjamin R

2016-01-01

Fluoride salt-cooled high temperature reactors (FHRs) are a promising reactor technology option with significant knowledge gaps to implementation. One potential approach to address those technology gaps is via a small-scale demonstration reactor with the goal of increasing the technology readiness level (TRL) of the overall system for the longer term. The objective of this paper is to outline a notional concept for such a system, and to address how the proposed concept would advance the TRL of FHR concepts. Development of the proposed FHR Demonstration Reactor (DR) will enable commercial FHR deployment through disruptive and rapid technology development and demonstration.more » The FHR DR will close remaining gaps to commercial viability. Lower risk technologies are included in the initial FHR DR design to ensure that the reactor can be built, licensed, and operated within an acceptable budget and schedule. Important capabilities that will be demonstrated by building and operating the FHR DR include core design methodologies; fabrication and operation of high temperature reactors; salt procurement, handling, maintenance, and ultimate disposal; salt chemistry control to maximize vessel life; tritium management; heat exchanger performance; pump performance; and reactivity control. The FHR DR is considered part of a broader set of FHR technology development and demonstration efforts, some of which are already underway. Nonreactor test efforts (e.g., heated salt loops or loops using simulant fluids) can demonstrate many technologies necessary for commercial deployment of FHRs. The FHR DR, however, fulfills a crucial role in FHR technology development by advancing the technical maturity and readiness level of the system as a whole.« less

Value of Information and Prospect theory as tools to involve decision-makers in water-related design, operation and planning of water systems

NASA Astrophysics Data System (ADS)

Alfonso, Leonardo

2013-04-01

The role of decision-makers is to take the outputs from hydrological and hydraulic analyses and, in some extent, use them as inputs to make decisions that are related to planning, design and operation of water systems. However, the use of these technical analyses is frequently limited, since there are other non-hydrological issues that must be considered, that may end up in very different solutions than those envisaged by the purely technical ones. A possibility to account for the nature of the human decisions under uncertainty is by exploring the use of concepts from decision theory and behavioural economics, such as Value of Information and Prospect Theory and embed them into the methodologies we use in the hydrology practice. Three examples are presented to illustrate these multidisciplinary interactions. The first one, for monitoring network design, uses Value of Information within a methodology to locate water level stations in a complex canal of networks in the Netherlands. The second example, for operation, shows how the Value of Information concept can be used to formulate alternative methods to evaluate flood risk according to the set of options available for decision-making during a flood event. The third example, for planning, uses Prospect Theory concepts to understand how the "losses hurt more than gains feel good" effect can determine the final decision of urbanise or not a flood-prone area. It is demonstrated that decision theory and behavioural economic principles are promising to evaluate the complex decision-making process in water-related issues.

An effective self-assessment based on concept map extraction from test-sheet for personalized learning

NASA Astrophysics Data System (ADS)

Liew, Keng-Hou; Lin, Yu-Shih; Chang, Yi-Chun; Chu, Chih-Ping

2013-12-01

Examination is a traditional way to assess learners' learning status, progress and performance after a learning activity. Except the test grade, a test sheet hides some implicit information such as test concepts, their relationships, importance, and prerequisite. The implicit information can be extracted and constructed a concept map for considering (1) the test concepts covered in the same question means these test concepts have strong relationships, and (2) questions in the same test sheet means the test concepts are relative. Concept map has been successfully employed in many researches to help instructors and learners organize relationships among concepts. However, concept map construction depends on experts who need to take effort and time for the organization of the domain knowledge. In addition, the previous researches regarding to automatic concept map construction are limited to consider all learners of a class, which have not considered personalized learning. To cope with this problem, this paper proposes a new approach to automatically extract and construct concept map based on implicit information in a test sheet. Furthermore, the proposed approach also can help learner for self-assessment and self-diagnosis. Finally, an example is given to depict the effectiveness of proposed approach.

Excellence in Teacher Education: Options for a Federal Partnership.

ERIC Educational Resources Information Center

Florio, David H.

An overview of options available for Federal cooperation in the improvement of teacher education considers possible areas in which government support may be effective. These include: (1) recruitment of talented students; (2) financial support for prospective teachers; (3) improvement grants to schools of education; (4) grants supporting…

Biomedical Engineering Education: A Conservative Approach

ERIC Educational Resources Information Center

Niemi, Eugene E., Jr.

1973-01-01

Describes the demand for graduates from biomedical engineering programs as being not yet fully able to absorb the supply. Suggests small schools interested in entering the field consider offering their programs at the undergraduate level via a minor or an option. Examples of such options and student projects are included. (CC)

7 CFR 3555.304 - Special servicing options.

Code of Federal Regulations, 2014 CFR

2014-01-01

... consider a mortgage recovery advance under this section in addition to the extended-term loan modification... required for taxes and insurance. (6) The following terms apply to the repayment of mortgage recovery... does not change the terms of the loan note guarantee. (4) Special servicing options shall be used in...

76 FR 76783 - Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-08

... Exchange may considering revising the fee schedule to assess transaction fees rates for non-Trading Permit... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-65875; File No. SR-CBOE-2011-112] Self-Regulatory Organizations; Chicago Board Options Exchange, Incorporated; Notice of Filing and Immediate...

12 CFR 350.4 - Contents of annual disclosure statement.

Code of Federal Regulations, 2010 CFR

2010-01-01

... for each such year. The annual disclosure statement may, at the option of bank management, consist of... Reserve System: (i) Schedule RC (Balance Sheet); (ii) Schedule RC-N (Past Due and Nonaccrual, Loans... option, provide additional information that bank management considers important to an evaluation of the...

Assessing Governance Alternatives for University-Owned Public Teaching Hospitals.

ERIC Educational Resources Information Center

Whitley, Evangeline L.

The governance options matrix is provided to offer a way for state and university policymakers to examine the functioning environments of specific university-owned public teaching hospitals. With it, they can consider the benefits and problems involved with different options for governance. The issues related to the environmental factors affecting…

Why the concept ''lifestyle diseases'' should be avoided.

PubMed

Vallgårda, Signild

2011-11-01

The concept lifestyle disease is used about a number of different diseases such as coronary heart disease, diabetes, lung cancer etc. The concept indicates that people's behaviours cause the diseases. This is only partly true. All diseases, both so-called lifestyle diseases and infectious diseases, have multiple causes. Singling out only one type of causes, such as is implied in the concept of lifestyle diseases can lead prevention to focus only on changing people s behaviours or lifestyles, and thus to neglect other possibilities to improve health. Mortality due to chronic diseases has increased during the last century and the main cause behind this is the decrease in the mortality in infectious diseases among younger people. More people live long enough to develop the chronic diseases. The concept lifestyle disease gives a too narrow picture of causes death and should be abandoned and give place for a broader understanding of causes and preventive options.