Requirements for Certification of Teachers, Counselors, Librarians, Administrators for Elementary and Secondary Schools. 61st Edition, 1996-97.

ERIC Educational Resources Information Center

Tryneski, John, Ed.

This publication offers an update in concise form of pertinent information for teachers, administrators, librarians, counselors, and other school personnel on certification requirements. Recommendations of regional and national associations regarding school staff responsibilities and school policies are presented, as well as current addresses for…

Friulian: The Friulian Language in Education in Italy. Regional Dossiers Series

ERIC Educational Resources Information Center

Petris, Cinzia, Comp.

2014-01-01

This regional dossier aims to provide a concise, description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

Catalan: The Catalan Language in Education in Spain, 2nd Edition. Regional Dossiers Series

ERIC Educational Resources Information Center

Areny, Maria, Comp.; Mayans, Pere, Comp.; Forniès, David, Comp.

2013-01-01

Regional dossiers aim at providing a concise description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

Comparative evaluation of microleakage of lingual retainer wires bonded with three different lingual retainer composites: an in vitro study.

PubMed

Nimbalkar-Patil, Smita; Vaz, Anna; Patil, Pravinkumar G

2014-11-01

To evaluate microleakage when two types of retainer wires were bonded with two light cured and a self cured lingual retainer composites. Total 120 freshly extracted human mandibular incisor teeth were collected and separated into six subgroups of 20 teeth each. Two different wires, a 0.036 inch hard round stainless steel (HRSS) wire sandblasted at the ends and 0.0175 inch multistranded wire bonded onto the lingual surfaces of the incisors with three different types of composite resins of 3M company; Concise Orthodontic (self-cure), Transbond XT (light-cure) and Transbond LR (light-cure). Specimens were further sealed with a nail varnish, stained with 0.5% basic fuchsine for 24 hours, sectioned and examined under a stereomicroscope, and scored for microleakage for the enamel-composite and wire-composite interfaces. Statistical analysis was performed by Kruskal-Wallis and Mann-Whitney U-tests. For HRSS wire, at the enamel-composite interface, the microleakage was least with Transbond LR followed by Concise Orthodontic and greatest for Transbond XT (p<0.05). At the wire composite interface too, the microleakage was in order of Transbond LR

Manx Gaelic: The Manx Gaelic Language in Education in the Isle of Man. Regional Dossiers Series

ERIC Educational Resources Information Center

McArdle, Fiona, Comp.; Teare, Robert, Comp.

2016-01-01

This regional dossier aims at providing a concise description of and basic statistics on minority language education in a specific region of Europe--the Isle of Man. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative…

Editors' Introduction to the Thematic Issue: Mad about Methods? Teaching Research Methods in Political Science

ERIC Educational Resources Information Center

Adriaensen, Johan; Kerremans, Bart; Slootmaeckers, Koen

2015-01-01

The contributors to this special issue all seek to address the challenge of teaching research methods to political science students. This introduction aims to provide a concise framework for the various innovations presented throughout this issue, situating them in the wider literature. Particular emphasis is placed on the factors that distinguish…

Not All Wizards Are from Oz: Iterative Design of Intelligent Learning Environments by Communication Capacity Tapering

ERIC Educational Resources Information Center

Mavrikis, Manolis; Gutierrez-Santos, Sergio

2010-01-01

This paper presents a methodology for the design of intelligent learning environments. We recognise that in the educational technology field, theory development and system-design should be integrated and rely on an iterative process that addresses: (a) the difficulty to elicit precise, concise, and operationalized knowledge from "experts" and (b)…

Sorbian: The Sorbian Language in Education in Germany, 2nd Edition. Regional Dossiers Series

ERIC Educational Resources Information Center

Brezan, Beate, Comp.; Nowak, Meto, Comp.

2016-01-01

This regional dossier aims to provide a concise, description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

North Frisian: The North Frisian Language in Education in Germany, 3rd Edition. Regional Dossiers Series

ERIC Educational Resources Information Center

Walker, Alastair G. H., Comp.

2015-01-01

This regional dossier aims to provide a concise, description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

Swedish: The Swedish Language in Education in Finland, 2nd Edition. Regional Dossiers Series

ERIC Educational Resources Information Center

Østern, Anna-Lena, Comp.; Harju-Luukkainen, Heidi, Comp.

2013-01-01

This regional dossier aims to provide a concise, description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

Ladin: The Ladin Language in Education in Italy, 2nd Edition. Regional Dossiers Series

ERIC Educational Resources Information Center

Verra, Roland, Comp.

2016-01-01

This regional dossier aims to provide a concise, description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

Galician: The Galician Language in Education in Spain, 2nd Edition. Regional Dossiers Series

ERIC Educational Resources Information Center

Costas, Xosé-Henrique, Comp.; Expósito-Loureiro, Andrea, Comp.

2016-01-01

This regional dossier aims to provide a concise, description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

Welsh: The Welsh Language in Education in the UK, 2nd Edition. Regional Dossiers Series

ERIC Educational Resources Information Center

Jones, Meirion Prys, Comp.; Jones, Ceinwen, Comp.

2014-01-01

This regional dossier aims to provide a concise, description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

Irish: The Irish Language in Education in the Republic of Ireland, 2nd Edition. Regional Dossiers Series

ERIC Educational Resources Information Center

Ó Murchú, Helen, Comp.

2016-01-01

This regional dossier aims to provide a concise, description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

Asturian: The Asturian Language in Education in Spain, 2nd Edition. Regional Dossiers Series

ERIC Educational Resources Information Center

González-Riaño, Xosé Antón, Comp.; Fernández-Costales, Alberto, Comp.

2014-01-01

This regional dossier aims to provide a concise, description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

50 CFR 221.55 - What evidence is admissible at the hearing?

Code of Federal Regulations, 2010 CFR

2010-10-01

... guidance by the ALJ and the parties in interpreting and applying the provisions of this section. (b) Objections. Any party objecting to the admission or exclusion of evidence shall concisely state the grounds...

7 CFR 1.655 - What evidence is admissible at the hearing?

Code of Federal Regulations, 2010 CFR

2010-01-01

... guidance by the ALJ and the parties in interpreting and applying the provisions of this section. (b) Objections. Any party objecting to the admission or exclusion of evidence shall concisely state the grounds...

Concept document of the repository-based software engineering program: A constructive appraisal

NASA Technical Reports Server (NTRS)

1992-01-01

A constructive appraisal of the Concept Document of the Repository-Based Software Engineering Program is provided. The Concept Document is designed to provide an overview of the Repository-Based Software Engineering (RBSE) Program. The Document should be brief and provide the context for reading subsequent requirements and product specifications. That is, all requirements to be developed should be traceable to the Concept Document. Applied Expertise's analysis of the Document was directed toward assuring that: (1) the Executive Summary provides a clear, concise, and comprehensive overview of the Concept (rewrite as necessary); (2) the sections of the Document make best use of the NASA 'Data Item Description' for concept documents; (3) the information contained in the Document provides a foundation for subsequent requirements; and (4) the document adequately: identifies the problem being addressed; articulates RBSE's specific role; specifies the unique aspects of the program; and identifies the nature and extent of the program's users.

Circus! Oregon ASCD Curriculum Bulletin, Vol. 30, No. 332, May 1976.

ERIC Educational Resources Information Center

Fenner, Mildred S.; Witter, Janet

This bulletin discusses the circus, as described by circus companies, and offers ideas by educators from several states for how to use circus-related topics in the classroom. The bulletin is divided into several sections. The first section defines and describes the circus, with a short history. Next, a concise 200-year history of the circus in the…

Nenets, Khanty and Selkup: The Nenets, Khanty and Selkup Language in Education in the Yamal Region in Russia. Regional Dossiers Series

ERIC Educational Resources Information Center

Laptander, Roza Ivanovna, Comp.

2016-01-01

This regional dossier aims to provide a concise, description and basic statistics about minority language education in a specific region of Europe. Aspects that are addressed include features of the education system, recent educational policies, main actors, legal arrangements, and support structures, as well as quantitative aspects, such as the…

How to Write Effective Procedure Manuals.

ERIC Educational Resources Information Center

Wold, Geoffrey H.

1987-01-01

Describes six key guidelines for developing usable procedure manuals, including defining the audience; designing a standard format; preparing an outline; using a clear, concise writing style; testing the procedures; and "finalizing" the product with indices, glossaries, appendices, and section tabs. Well-written manuals can increase…

48 CFR 5.704 - Publicizing preaward.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Publicizing preaward. 5.704 Section 5.704 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION...), use clear and concise language to describe the planned procurement. Use descriptions of the goods and...

48 CFR 5.704 - Publicizing preaward.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Publicizing preaward. 5.704 Section 5.704 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION...), use clear and concise language to describe the planned procurement. Use descriptions of the goods and...

48 CFR 5.704 - Publicizing preaward.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Publicizing preaward. 5.704 Section 5.704 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION...), use clear and concise language to describe the planned procurement. Use descriptions of the goods and...

48 CFR 5.704 - Publicizing preaward.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Publicizing preaward. 5.704 Section 5.704 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION...), use clear and concise language to describe the planned procurement. Use descriptions of the goods and...

48 CFR 5.704 - Publicizing preaward.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Publicizing preaward. 5.704 Section 5.704 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION ACQUISITION...), use clear and concise language to describe the planned procurement. Use descriptions of the goods and...

40 CFR 164.22 - Contents of document setting forth objections.

Code of Federal Regulations, 2011 CFR

2011-07-01

... objections. 164.22 Section 164.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... RODENTICIDE ACT, ARISING FROM REFUSALS TO REGISTER, CANCELLATIONS OF REGISTRATIONS, CHANGES OF CLASSIFICATIONS... registration, or change the classification of a pesticide, shall clearly and concisely set forth such...

40 CFR 164.22 - Contents of document setting forth objections.

Code of Federal Regulations, 2010 CFR

2010-07-01

... objections. 164.22 Section 164.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... RODENTICIDE ACT, ARISING FROM REFUSALS TO REGISTER, CANCELLATIONS OF REGISTRATIONS, CHANGES OF CLASSIFICATIONS... registration, or change the classification of a pesticide, shall clearly and concisely set forth such...

40 CFR 1508.9 - Environmental assessment.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Environmental assessment. 1508.9 Section 1508.9 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY TERMINOLOGY AND INDEX § 1508.9 Environmental assessment. Environmental assessment: (a) Means a concise public document for which a Federal...

Attitudes and Action.

ERIC Educational Resources Information Center

Glander, Molly H.; O'Donnell, William J.

This handbook provides sexual information for college students. Though designed for students at North Carolina State University, it is a good model for similar publications on other campuses. The booklet begins by defining different forms of sexual activity--solo, casual, relational, and procreational. Other sections provide concise information on…

The Language of Library Leadership: Effective Communication.

ERIC Educational Resources Information Center

Hanson, Charles D.

This paper examines the role of communication in library leadership. The discussion is organized into 14 sections: (1) multidimensional approaches to effective leadership communication and varying communication style to the situation; (2) the importance of conciseness; (3) streamlining library communication; (4) the vision being communicated by…

40 CFR 1508.9 - Environmental assessment.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Environmental assessment. 1508.9 Section 1508.9 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY TERMINOLOGY AND INDEX § 1508.9 Environmental assessment. Environmental assessment: (a) Means a concise public document for which a Federal...

5 CFR 297.307 - Statement of disagreement.

Code of Federal Regulations, 2010 CFR

2010-01-01

... Section 297.307 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PRIVACY... concise statement of disagreement. Such a statement should be filed with the appropriate system manager... system manager should provide a copy of the statement of disagreement to any individual or agency to whom...

5 CFR 297.307 - Statement of disagreement.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Section 297.307 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PRIVACY... concise statement of disagreement. Such a statement should be filed with the appropriate system manager... system manager should provide a copy of the statement of disagreement to any individual or agency to whom...

Solar Energy Information and Education Project. Final Report.

ERIC Educational Resources Information Center

Hensley, Michael

The New Mexico Solar Energy Institute (NMSEI) conducted a concentrated information and education program during 1985. This report summarizes NMSEI's Information and Education project activities. It provides detailed descriptions of project costs and concise recommendations for similar programs. Individual sections contain explanations of the scope…

Evaluation of the remineralization potential of amorphous calcium phosphate and fluoride containing pit and fissure sealants using scanning electron microscopy.

PubMed

Choudhary, Prashant; Tandon, Shobha; Ganesh, M; Mehra, Anshul

2012-01-01

To evaluate the remineralization potential of Amorphous Calcium Phosphate (ACP) and Fluoride containing pit and Fissure Sealants using Scanning Electron Microscopy. Thirty maxillary first premolars were divided into three groups of ten each and were randomly selected for ACP containing (Aegis- Opaque White, Bosworth Co. Ltd.), Fluoride containing (Teethmate F1 Natural Clear, Kuraray Co. Ltd.), resin based (Concise- Opaque White, 3M ESPE Co. Ltd.) pit and fissure sealant applications. The Concise group served as a control. The teeth weresubjected to the pH-cycling regimen for a period of two weeks. After two weeks, the teeth were sectioned bucco-lingually into 4mm sections and were observed under Scanning Electron Microscope at 50X, 250X, 500X, 1000X and 1500X magnifications. The qualitative changes at the tooth surface and sealant interface were examined and presence of white zone at the interface was considered positive for remineralization. Both ACP containing (Aegis) and Fluoride containing (Teethmate F1) group showed white zone at the tooth surface-sealant interface. The resin based group (Concise) showed regular interface between the sealant and the tooth structure, but no clear cut white zone was observed. Both, Aegis and Teethmate F1 have the potential to remineralize. Release of Amorphous Calcium Phosphate molecules in Aegis group and formation of Fluoroapetite in Teethmate F1 group, were probably responsible for the remineralization.

Information, Education, Communication in Population.

ERIC Educational Resources Information Center

Hawaii Univ., Honolulu. East-West Center.

Programs and services of the Swedish International Development Authority (SIDA) are reviewed in this report on resources available for the support of population information, education, and communication activities. Four major sections describe in concise, outline form: (1) the agency and its programs, (2) the specific program in population/family…

Outline of Polish Morphology.

ERIC Educational Resources Information Center

Bidwell, Charles E.

This volume, one of a series of concise but relatively exhaustive descriptions of the grammatical structures of the principal standard Slavic languages, contains an outline of Polish morphology. The four major sections are morphophonemics, nominal inflection, the Polish verb (Part 1--stem alternation and conjugation, and the Polish verb (Part…

U.S. Army Civil Affairs and Political Transformation in Occupation: Lustration and Recasting Society

DTIC Science & Technology

2017-06-09

the nuances of program execution by the German people , and the society at large. 74 Dobbins et al...for the occupation for the German people in five concise paragraphs, the first directly addressed Nazism and its future in German society : The Allied...Freedom Message to the Iraqi People ,” quoted in Tommy Franks, American Soldier (New York: Harper Collins, 2004) 528. 93 Ambassador and American

Testing and Standards: A Brief Encyclopedia.

ERIC Educational Resources Information Center

Wilde, Sandra

This reference guide contains clear and concise explanations of concepts related to educational testing and standards. The book may be read straight through as a primer on educational assessment or may be used as a reference for particular topics. The sections are: (1) Accountability (Consumers, Taxpayers, and Citizens); (2) Authenticity in…

29 CFR 458.67 - Standards complaint; initiation of proceedings.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Section 458.67 Labor Regulations Relating to Labor OFFICE OF LABOR-MANAGEMENT STANDARDS, DEPARTMENT OF... believes it appropriate, refrain from disclosing the identity of any person who called the violation to his... shall include the following: (a) The name and identity of each respondent. (b) A clear and concise...

27 CFR 44.142 - Records.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false Records. 44.142 Section 44... PAYMENT OF TAX, OR WITH DRAWBACK OF TAX Operations by Export Warehouse Proprietors § 44.142 Records. Every export warehouse proprietor must keep in such warehouse complete and concise records, containing the: (a...

29 CFR 1404.5 - Listing on the roster, criteria for listing and removal, procedure for removal.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) of this section are preferably demonstrated by the submission of five recent arbitration awards... MEDIATION AND CONCILIATION SERVICE ARBITRATION SERVICES Roster of Arbitrators; Admission and Retention... exhibits and can prepare clear and concise findings and awards within reasonable time limits. (iv) For...

A Concise Dictionary of Minnesota Ojibwe.

ERIC Educational Resources Information Center

Nichols, John D.; Nyholm, Earl

The dictionary of the Ojibwa or Chippewa language represents the speech of the Mille Lacs Band of Minnesota and contains over 7,000 Ojibwa terms. Each entry gives information on the word stem, grammatical classification, English gloss, form variations, and references to alternate forms. An introductory section describes the entry format and use,…

46 CFR 502.186 - Contents of memoranda.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 9 2013-10-01 2013-10-01 false Contents of memoranda. 502.186 Section 502.186 Shipping FEDERAL MARITIME COMMISSION GENERAL AND ADMINISTRATIVE PROVISIONS RULES OF PRACTICE AND PROCEDURE Shortened Procedure § 502.186 Contents of memoranda. The memorandum should contain concise arguments and fact, the same as would be offered if a formal...

39 CFR 3030.14 - Answer contents.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Answer contents. 3030.14 Section 3030.14 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL RULES FOR COMPLAINTS Form and Manner Requirements of Initial Pleadings § 3030.14 Answer contents. (a) An answer must: (1) Contain a clear and concise statement of any disputed factual allegations upon...

46 CFR 502.186 - Contents of memoranda.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 9 2010-10-01 2010-10-01 false Contents of memoranda. 502.186 Section 502.186 Shipping FEDERAL MARITIME COMMISSION GENERAL AND ADMINISTRATIVE PROVISIONS RULES OF PRACTICE AND PROCEDURE Shortened Procedure § 502.186 Contents of memoranda. The memorandum should contain concise arguments and fact, the same as would be offered if a formal...

West Virginia Department of Transportation (WVDOT) hosted a peer exchange from October 19 \\0x2010 October 22, 2010.

DOT National Transportation Integrated Search

2010-10-01

The expressed objectives of the Peer Exchange were to discuss : 1) A draft revised policy manual for the RSS Section that in its final form is clear, concise, : and a standalone document. : 2) Strengths and weaknesses of the outlined policies. : 3...

26 CFR 1.6033-3 - Additional provisions relating to private foundations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... to private foundations. (a) In general. The foundation managers (as defined in section 4946(b)) of... contributions made or approved for future payment during the year, showing the amount of each such grant or... foundation's managers or substantial contributors, and a concise statement of the purpose of each such grant...

12 CFR 222.21 - Affiliate marketing opt-out and exceptions.

Code of Federal Regulations, 2014 CFR

2014-01-01

....21 Section 222.21 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE... Affiliate marketing opt-out and exceptions. (a) Initial notice and opt-out requirement—(1) In general. You... the consumer in writing or, if the consumer agrees, electronically, in a concise notice that you may...

21 CFR 25.43 - Records of decision.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Records of decision. 25.43 Section 25.43 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ENVIRONMENTAL IMPACT... environmental impact statements, at the time of its decision, the agency shall prepare a concise public record...

The Handbook of Literacy Assessment and Evaluation. Second Edition.

ERIC Educational Resources Information Center

Harp, Bill

This handbook gives teachers, reading specialists, administrators, or students concise, up-to-date information on the most popular assessment and evaluation tools in literacy. This second edition retains many of the tools reviewed in the first edition and adds 12 new tools. The first section reviews 24 tools that are teacher-made. The second…

Error-free holographic frames encryption with CA pixel-permutation encoding algorithm

NASA Astrophysics Data System (ADS)

Li, Xiaowei; Xiao, Dan; Wang, Qiong-Hua

2018-01-01

The security of video data is necessary in network security transmission hence cryptography is technique to make video data secure and unreadable to unauthorized users. In this paper, we propose a holographic frames encryption technique based on the cellular automata (CA) pixel-permutation encoding algorithm. The concise pixel-permutation algorithm is used to address the drawbacks of the traditional CA encoding methods. The effectiveness of the proposed video encoding method is demonstrated by simulation examples.

[The dynamic concision for three-dimensional reconstruction of human organ built with virtual reality modeling language (VRML)].

PubMed

Yu, Zhengyang; Zheng, Shusen; Chen, Huaiqing; Wang, Jianjun; Xiong, Qingwen; Jing, Wanjun; Zeng, Yu

2006-10-01

This research studies the process of dynamic concision and 3D reconstruction from medical body data using VRML and JavaScript language, focuses on how to realize the dynamic concision of 3D medical model built with VRML. The 2D medical digital images firstly are modified and manipulated by 2D image software. Then, based on these images, 3D mould is built with VRML and JavaScript language. After programming in JavaScript to control 3D model, the function of dynamic concision realized by Script node and sensor node in VRML. The 3D reconstruction and concision of body internal organs can be formed in high quality near to those got in traditional methods. By this way, with the function of dynamic concision, VRML browser can offer better windows of man-computer interaction in real time environment than before. 3D reconstruction and dynamic concision with VRML can be used to meet the requirement for the medical observation of 3D reconstruction and has a promising prospect in the fields of medical image.

Dynamic concision for three-dimensional reconstruction of human organ built with virtual reality modelling language (VRML).

PubMed

Yu, Zheng-yang; Zheng, Shu-sen; Chen, Lei-ting; He, Xiao-qian; Wang, Jian-jun

2005-07-01

This research studies the process of 3D reconstruction and dynamic concision based on 2D medical digital images using virtual reality modelling language (VRML) and JavaScript language, with a focus on how to realize the dynamic concision of 3D medical model with script node and sensor node in VRML. The 3D reconstruction and concision of body internal organs can be built with such high quality that they are better than those obtained from the traditional methods. With the function of dynamic concision, the VRML browser can offer better windows for man-computer interaction in real-time environment than ever before. 3D reconstruction and dynamic concision with VRML can be used to meet the requirement for the medical observation of 3D reconstruction and have a promising prospect in the fields of medical imaging.

Dynamic concision for three-dimensional reconstruction of human organ built with virtual reality modelling language (VRML)*

PubMed Central

Yu, Zheng-yang; Zheng, Shu-sen; Chen, Lei-ting; He, Xiao-qian; Wang, Jian-jun

2005-01-01

This research studies the process of 3D reconstruction and dynamic concision based on 2D medical digital images using virtual reality modelling language (VRML) and JavaScript language, with a focus on how to realize the dynamic concision of 3D medical model with script node and sensor node in VRML. The 3D reconstruction and concision of body internal organs can be built with such high quality that they are better than those obtained from the traditional methods. With the function of dynamic concision, the VRML browser can offer better windows for man-computer interaction in real-time environment than ever before. 3D reconstruction and dynamic concision with VRML can be used to meet the requirement for the medical observation of 3D reconstruction and have a promising prospect in the fields of medical imaging. PMID:15973760

46 CFR 502.54 - Contents of rules.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 9 2013-10-01 2013-10-01 false Contents of rules. 502.54 Section 502.54 Shipping FEDERAL MARITIME COMMISSION GENERAL AND ADMINISTRATIVE PROVISIONS RULES OF PRACTICE AND PROCEDURE Rulemaking § 502.54 Contents of rules. The Commission will incorporate in any publication of proposed or final rules a concise and general statement of their...

10 CFR 1003.35 - Contents.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Contents. 1003.35 Section 1003.35 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) OFFICE OF HEARINGS AND APPEALS PROCEDURAL REGULATIONS Appeals § 1003.35 Contents. (a) The appeal shall contain a concise statement of grounds upon which it is brought and a description of the relief sought. It shall include ...

31 CFR 8.55 - Contents of complaint.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance: Treasury 1 2014-07-01 2014-07-01 false Contents of complaint. 8.55 Section 8.55 Money and Finance: Treasury Office of the Secretary of the Treasury PRACTICE BEFORE THE BUREAU OF ALCOHOL, TOBACCO AND FIREARMS Disciplinary Proceedings § 8.55 Contents of complaint. (a) Charges. A complaint will give a plain and concise...

10 CFR 1003.35 - Contents.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Contents. 1003.35 Section 1003.35 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) OFFICE OF HEARINGS AND APPEALS PROCEDURAL REGULATIONS Appeals § 1003.35 Contents. (a) The appeal shall contain a concise statement of grounds upon which it is brought and a description of the relief sought. It shall include ...

46 CFR 201.64 - Contents of rules.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 8 2012-10-01 2012-10-01 false Contents of rules. 201.64 Section 201.64 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION POLICY, PRACTICE AND PROCEDURE RULES OF PRACTICE AND PROCEDURE Rule Making (Rule 6) § 201.64 Contents of rules. The Administration will incorporate in any rule to be adopted a concise general statement...

10 CFR 1003.35 - Contents.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Contents. 1003.35 Section 1003.35 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) OFFICE OF HEARINGS AND APPEALS PROCEDURAL REGULATIONS Appeals § 1003.35 Contents. (a) The appeal shall contain a concise statement of grounds upon which it is brought and a description of the relief sought. It shall include ...

46 CFR 502.54 - Contents of rules.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 9 2010-10-01 2010-10-01 false Contents of rules. 502.54 Section 502.54 Shipping FEDERAL MARITIME COMMISSION GENERAL AND ADMINISTRATIVE PROVISIONS RULES OF PRACTICE AND PROCEDURE Rulemaking § 502.54 Contents of rules. The Commission will incorporate in any rules adopted a concise general statement of their basis and purpose. [Rule 54....

10 CFR 1003.35 - Contents.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Contents. 1003.35 Section 1003.35 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) OFFICE OF HEARINGS AND APPEALS PROCEDURAL REGULATIONS Appeals § 1003.35 Contents. (a) The appeal shall contain a concise statement of grounds upon which it is brought and a description of the relief sought. It shall include ...

10 CFR 1003.35 - Contents.

Code of Federal Regulations, 2010 CFR

2007-01-01

... 10 Energy 4 2007-01-01 2007-01-01 false Contents. 1003.35 Section 1003.35 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) OFFICE OF HEARINGS AND APPEALS PROCEDURAL REGULATIONS Appeals § 1003.35 Contents. (a) The appeal shall contain a concise statement of grounds upon which it is brought and a description of the relief sought. It shall include ...

10 CFR 1003.35 - Contents.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Contents. 1003.35 Section 1003.35 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) OFFICE OF HEARINGS AND APPEALS PROCEDURAL REGULATIONS Appeals § 1003.35 Contents. (a) The appeal shall contain a concise statement of grounds upon which it is brought and a description of the relief sought. It shall include ...

Cardiac imaging: does radiation matter?

PubMed Central

Einstein, Andrew J.; Knuuti, Juhani

2012-01-01

The use of ionizing radiation in cardiovascular imaging has generated considerable discussion. Radiation should not be considered in isolation, but rather in the context of a careful examination of the benefits, risks, and costs of cardiovascular imaging. Such consideration requires an understanding of some fundamental aspects of the biology, physics, epidemiology, and terminology germane to radiation, as well as principles of radiological protection. This paper offers a concise, contemporary perspective on these areas by addressing pertinent questions relating to radiation and its application to cardiac imaging. PMID:21828062

Reciprocity relations in transmission electron microscopy: A rigorous derivation.

PubMed

Krause, Florian F; Rosenauer, Andreas

2017-01-01

A concise derivation of the principle of reciprocity applied to realistic transmission electron microscopy setups is presented making use of the multislice formalism. The equivalence of images acquired in conventional and scanning mode is thereby rigorously shown. The conditions for the applicability of the found reciprocity relations is discussed. Furthermore the positions of apertures in relation to the corresponding lenses are considered, a subject which scarcely has been addressed in previous publications. Copyright © 2016 Elsevier Ltd. All rights reserved.

The clinical effectiveness of concise cognitive behavioral therapy with or without pharmacotherapy for depressive and anxiety disorders; a pragmatic randomized controlled equivalence trial in clinical practice.

PubMed

Meuldijk, D; Carlier, I V E; van Vliet, I M; van Veen, T; Wolterbeek, R; van Hemert, A M; Zitman, F G

2016-03-01

Depressive and anxiety disorders contribute to a high disease burden. This paper investigates whether concise formats of cognitive behavioral- and/or pharmacotherapy are equivalent with longer standard care in the treatment of depressive and/or anxiety disorders in secondary mental health care. A pragmatic randomized controlled equivalence trial was conducted at five Dutch outpatient Mental Healthcare Centers (MHCs) of the Regional Mental Health Provider (RMHP) 'Rivierduinen'. Patients (aged 18-65 years) with a mild to moderate anxiety and/or depressive disorder, were randomly allocated to concise or standard care. Data were collected at baseline, 3, 6 and 12 months by Routine Outcome Monitoring (ROM). Primary outcomes were the Brief Symptom Inventory (BSI) and the Web Screening Questionnaire (WSQ). We used Generalized Estimating Equations (GEE) to assess outcomes. Between March 2010 and December 2012, 182 patients, were enrolled (n=89 standard care; n=93 concise care). Both intention-to-treat and per-protocol analyses demonstrated equivalence of concise care and standard care at all time points. Severity of illness reduced, and both treatments improved patient's general health status and subdomains of quality of life. Moreover, in concise care, the beneficial effects started earlier. Concise care has the potential to be a feasible and promising alternative to longer standard secondary mental health care in the treatment of outpatients with a mild to moderate depressive and/or anxiety disorder. For future research, we recommend adhering more strictly to the concise treatment protocols to further explore the beneficial effects of the concise treatment. The study is registered in the Netherlands Trial Register, number NTR2590. Clinicaltrials.gov identifier: NCT01643642. Copyright © 2015 Elsevier Inc. All rights reserved.

Joint proceedings, Second Genetics Workshop of the Society of American Foresters and Seventh Lake States Forest Tree Improvement Conference, October 21-23, 1965.

Treesearch

NCFES

1966-01-01

Included are (1) 22 technical papers (by researchers from many sections of the United States and Canada) pertaining to selection and progeny testing, radiation genetics, intraspecific variation, natural and artificial hybridization, breeding systems, breeding methodology and specialized tree breeding techniques, and applied breeding and allied fields; (2) concise...

10 CFR § 1003.35 - Contents.

Code of Federal Regulations, 2010 CFR

2017-01-01

... 10 Energy 4 2017-01-01 2017-01-01 false Contents. § 1003.35 Section § 1003.35 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) OFFICE OF HEARINGS AND APPEALS PROCEDURAL REGULATIONS Appeals § 1003.35 Contents. (a) The appeal shall contain a concise statement of grounds upon which it is brought and a description of the relief sought. It shall...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sivaraman, Chitra

The purpose of this report is to provide a concise status update for value-added products (VAP) implemented by the Atmospheric Radiation Measurement Climate Research Facility. The report is divided into the following sections: (1) new VAPs for which development has begun, (2) progress on existing VAPs, (3) future VAPs that have been recently approved, (4) other work that leads to a VAP, and (5) top requested VAPs from the archive.

Rule extraction from minimal neural networks for credit card screening.

PubMed

Setiono, Rudy; Baesens, Bart; Mues, Christophe

2011-08-01

While feedforward neural networks have been widely accepted as effective tools for solving classification problems, the issue of finding the best network architecture remains unresolved, particularly so in real-world problem settings. We address this issue in the context of credit card screening, where it is important to not only find a neural network with good predictive performance but also one that facilitates a clear explanation of how it produces its predictions. We show that minimal neural networks with as few as one hidden unit provide good predictive accuracy, while having the added advantage of making it easier to generate concise and comprehensible classification rules for the user. To further reduce model size, a novel approach is suggested in which network connections from the input units to this hidden unit are removed by a very straightaway pruning procedure. In terms of predictive accuracy, both the minimized neural networks and the rule sets generated from them are shown to compare favorably with other neural network based classifiers. The rules generated from the minimized neural networks are concise and thus easier to validate in a real-life setting.

Nature: a new paradigm for well-being and ergonomics.

PubMed

Richardson, Miles; Maspero, Marta; Golightly, David; Sheffield, David; Staples, Vicki; Lumber, Ryan

2017-02-01

Nature is presented as a new paradigm for ergonomics. As a discipline concerned with well-being, the importance of natural environments for wellness should be part of ergonomics knowledge and practice. This position is supported by providing a concise summary of the evidence of the value of the natural environment to well-being. Further, an emerging body of research has found relationships between well-being and a connection to nature, a concept that reveals the integrative character of human experience which can inform wider practice and epistemology in ergonomics. Practitioners are encouraged to bring nature into the workplace, so that ergonomics keeps pace with the move to nature-based solutions, but also as a necessity in the current ecological and social context. Practitioner Summary: Nature-based solutions are coming to the fore to address societal challenges such as well-being. As ergonomics is concerned with well-being, there is a need for a paradigm shift in the discipline. This position is supported by providing a concise summary of the evidence of the value of the natural environment to well-being.

22 CFR 216.9 - Bilateral and multilateral studies and concise reviews of environmental issues.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Bilateral and multilateral studies and concise... DEVELOPMENT ENVIRONMENTAL PROCEDURES § 216.9 Bilateral and multilateral studies and concise reviews of... or multilateral environmental studies, relevant or related to the proposed action, prepared by the...

22 CFR 216.9 - Bilateral and multilateral studies and concise reviews of environmental issues.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Bilateral and multilateral studies and concise... DEVELOPMENT ENVIRONMENTAL PROCEDURES § 216.9 Bilateral and multilateral studies and concise reviews of... or multilateral environmental studies, relevant or related to the proposed action, prepared by the...

Artificial Muscle (AM) Cilia Array for Underwater Systems

DTIC Science & Technology

2016-12-15

structures, including cilia-like structures. Specifically, a custom 3D printer was created that utilizes custom-made Nafion filament for 30 printing of custom... printing ) of IPMC material to create custom-shaped AM structures, including cilia-like structures. Various custom-shaped AM structures were fabricated via...integrating square cross-section IPMC actuators with a printed circuit board power delivery system. IV. Concise Accomplishments Performance

Education in the Arab Region Viewed from the 1970 Marrakesh Conference. Educational Studies and Documents Number 1.

ERIC Educational Resources Information Center

El-Ghannam, Mohammed A.

Designed to provide a comprehensive and concise picture of education in the Arab region, this booklet is the outgrowth of one of a series of conferences organized by UNESCO. The material is organized into three sections: the social and economic background of the Arab region; recent achievements and existing problems of education in the Arab…

School Crime Handbook. Summary of California Penal and Civil Laws Pertaining to Crimes Committed against Persons or Property on School Grounds.

ERIC Educational Resources Information Center

California State Office of the Attorney General, Sacramento.

This handbook was prepared to ensure that, as required by section 626.1 of the California Penal Code in 1984, "students, parents, and all school officials and employees have access to a concise, easily understandable summary of California penal and civil law pertaining to crimes committed against persons or property on school grounds."…

ACRF Instrumentation Status: New, Current, and Future - October – November 2007

DOE Office of Scientific and Technical Information (OSTI.GOV)

JW Voyles

2007-11-30

The purpose of this report is to provide a concise but comprehensive overview of Atmospheric Radiation Measurement (ARM) Climate Research Facility (ACRF) instrumentation status. The report is divided into the following four sections: (1) new instrumentation in the process of being acquired and deployed, (2) existing instrumentation and progress on improvements or upgrades, (3) proposed future instrumentation, and (4) SBIR instrument development.

Scaling Cross Sections for Ion-atom Impact Ionization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Igor D. Kaganovich; Edward Startsev; Ronald C. Davidson

2003-06-06

The values of ion-atom ionization cross sections are frequently needed for many applications that utilize the propagation of fast ions through matter. When experimental data and theoretical calculations are not available, approximate formulas are frequently used. This paper briefly summarizes the most important theoretical results and approaches to cross section calculations in order to place the discussion in historical perspective and offer a concise introduction to the topic. Based on experimental data and theoretical predictions, a new fit for ionization cross sections is proposed. The range of validity and accuracy of several frequently used approximations (classical trajectory, the Born approximation,more » and so forth) are discussed using, as examples, the ionization cross sections of hydrogen and helium atoms by various fully stripped ions.« less

Randomization to Standard and Concise Informed Consent Forms: Development of Evidence-Based Consent Practices

PubMed Central

Enama, Mary E.; Hu, Zonghui; Gordon, Ingelise; Costner, Pamela; Ledgerwood, Julie E.; Grady, Christine

2012-01-01

Background Consent to participate in research is an important component of the conduct of ethical clinical trials. Current consent practices are largely policy-driven. This study was conducted to assess comprehension of study information and satisfaction with the consent form between subjects randomized to concise or to standard informed consent forms as one approach to developing evidence-based consent practices. Methods Participants (N=111) who enrolled into two Phase I investigational influenza vaccine protocols (VRC 306 and VRC 307) at the NIH Clinical Center were randomized to one of two IRB-approved consents; either a standard or concise form. Concise consents had an average of 63% fewer words. All other aspects of the consent process were the same. Questionnaires about the study and the consent process were completed at enrollment and at the last visit in both studies. Results Subjects using concise consent forms scored as well as those using standard length consents in measures of comprehension (7 versus 7, p=0.79 and 20 versus 21, p=0.13), however, the trend was for the concise consent group to report feeling better informed. Both groups thought the length and detail of the consent form was appropriate. Conclusions Randomization of study subjects to different length IRB-approved consents forms as one method for developing evidence-based consent practices, resulted in no differences in study comprehension or satisfaction with the consent form. A concise consent form may be used ethically in the context of a consent process conducted by well-trained staff with opportunities for discussion and education throughout the study. PMID:22542645

Delta's Key to the Next Generation TOEFL[R] Test: Six Practice Tests for the iBT

ERIC Educational Resources Information Center

Gallagher, Nancy

2012-01-01

Six Practice Tests for the iBT gives students plenty of practice as they prepare for the Internet-based TOEFL (iBT) or the new form of the institutional TOEFL (ITP). This new book/audio set contains a concise description of the TOEFL and the types of questions in each section, as well as six full-length tests that have not been published before.…

Engaging Students with Active Thinking

NASA Astrophysics Data System (ADS)

Wieman, Carl E.

This Peer Review issue focuses on science and engaged learning. As any advertising executive or politician can tell you, engaging people is all about attitudes and beliefs, not abstract tacts. There is a lot we can learn from these professional communicators about how to effectively engage students. Far too often we, as educators, provide students with the content of science-often in the distilled formal representations that we have found to be the most concise and general-but fail to address students' own attitudes and beliefs. (Although heaven forbid that we should totally abandon reason and facts, as is typical in politics and advertising).

Comets and life in the Universe

NASA Technical Reports Server (NTRS)

Oro, J.; Mills, T.; Lazcano, A.

1995-01-01

The notion that comets supplied the primitive Earth with the requisite chemical species for the process of chemical evolution, which is widely held to have led to the origin of life on Earth, has now gained considerable intellectual momentum since its first formulation in 1961. The role of comets in the Earth's biogenesis has been thoroughly addressed in the literature. At this time, in light of a few recent findings, we present here a concise review of this topic together with a brief discussion of the possible role of cometary material in the origin of life elsewhere in the Universe.

Blood banking and transfusion medicine for the apheresis medicine practitioner.

PubMed

Jeffus, Susanne; Wehrli, Gay

2012-01-01

This article provides a concise overview of blood banking and transfusion medicine (BBTM) for the therapeutic apheresis medicine practitioner. It addresses the complete pathway from blood donor qualification to blood collection, to processing and storing blood components, to patient testing, to ordering blood components for therapeutic apheresis (TA) procedures, to preparing the component for transfusion, and finally to transfusion. The nurses, technologists, and physicians orchestrate these activities in concert to best serve patients undergoing TA procedures. Enhancing knowledge of these processes may improve the quality of patient care and the utilization of blood products. Copyright © 2012 Wiley Periodicals, Inc.

Inferential Framework for Autonomous Cryogenic Loading Operations

NASA Technical Reports Server (NTRS)

Luchinsky, Dmitry G.; Khasin, Michael; Timucin, Dogan; Sass, Jared; Perotti, Jose; Brown, Barbara

2017-01-01

We address problem of autonomous cryogenic management of loading operations on the ground and in space. As a step towards solution of this problem we develop a probabilistic framework for inferring correlations parameters of two-fluid cryogenic flow. The simulation of two-phase cryogenic flow is performed using nearly-implicit scheme. A concise set of cryogenic correlations is introduced. The proposed approach is applied to an analysis of the cryogenic flow in experimental Propellant Loading System built at NASA KSC. An efficient simultaneous optimization of a large number of model parameters is demonstrated and a good agreement with the experimental data is obtained.

Prospects for future climate change and the reasons for early action: critical review discussion

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sylvia A. Edgerton; Mark Z. Jacobson; Alberto Ayala

2008-11-15

This paper presents a discussion of the 2008 A&WMA Critical Review (see Coal Abstracts Oct 2008 00143) by invited panellists and others who chose to comment. It includes written submissions and presentation of transcripts that were, in a few instances, edited for conciseness, to minimize redundancy, and to provide supporting and instructional citations. Substantial deviations from the intent of a discussant are unintentional and can be addressed in a follow-up letter to the journal. The invited discussants are: Dr. Mark Jacobson, Dr. Albertao Ayala, Dr Carol Whiteman and Dr Mark Trexlor. 4 figs.

Concise Review: Guidance in Developing Commercializable Autologous/Patient-Specific Cell Therapy Manufacturing

PubMed Central

Armant, Myriam; Brandwein, Harvey; Burger, Scott; Campbell, Andrew; Carpenito, Carmine; Clarke, Dominic; Fong, Timothy; Karnieli, Ohad; Niss, Knut; Van't Hof, Wouter; Wagey, Ravenska

2013-01-01

Cell therapy is poised to play an enormous role in regenerative medicine. However, little guidance is being made available to academic and industrial entities in the start-up phase. In this technical review, members of the International Society for Cell Therapy provide guidance in developing commercializable autologous and patient-specific manufacturing strategies from the perspective of process development. Special emphasis is placed on providing guidance to small academic or biotech researchers as to what simple questions can be addressed or answered at the bench in order to make their cell therapy products more feasible for commercial-scale production. We discuss the processes that are required for scale-out at the manufacturing level, and how many questions can be addressed at the bench level. The goal of this review is to provide guidance in the form of topics that can be addressed early in the process of development to better the chances of the product being successful for future commercialization. PMID:24101671

Out of the lab and into the fab: Nano-alignment as an enabler for Silicon Photonics' next chapter

NASA Astrophysics Data System (ADS)

Jordan, Scott

2017-06-01

The rapid advent of Silicon Photonics presents many challenges for test and packaging. Here we concisely review SiP device attributes that differ significantly from classical photonic configurations, with a view to the future beyond current, connectivity-oriented silicon photonics developments, looking to such endeavors as all-optical computing and quantum computing. The necessity for nano-precision alignment of optical elements in test and packaging operations quickly emerges as the unfilled need. We review the industrial test and packaging solutions developed back in the 1997-2001 photonics boom to address the needs of that era's devices, and map their gaps with the new SiP device classes. Finally we review the new state-of-the-art of recent advances in the field that address these gaps.

Misfit stresses in a composite core-shell nanowire with an eccentric parallelepipedal core subjected to one-dimensional cross dilatation eigenstrain

NASA Astrophysics Data System (ADS)

Krasnitckii, S. A.; Kolomoetc, D. R.; Smirnov, A. M.; Gutkin, M. Yu

2017-03-01

We present an analytical solution to the boundary-value problem in the classical theory of elasticity for a core-shell nanowire with an eccentric parallelepipedal core of an arbitrary rectangular cross section. The core is subjected to one-dimensional cross dilatation eigenstrain. The misfit stresses are found in a concise and transparent closed form which is convenient for practical use in theoretical modeling of misfit relaxation processes.

ARM Climate Research Facility Quarterly Ingest Status Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koontz, A.; Sivaraman, C.

2016-10-01

The purpose of this report is to provide a concise status update for ingests maintained by the Atmospheric Radiation Measurement (ARM) Climate Research Facility. The report is divided into the following sections: (1) new ingests for which development has begun, (2) progress on existing ingests, (3) future ingests that have been recently approved, (4) other work that leads to an ingest, and (5) top requested ingests from the ARM Data Archive. New information is highlighted in blue text.

ARM Climate Research Facility Quarterly Ingest Status Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Koontz, A.; Sivaraman, C.

2016-07-01

The purpose of this report is to provide a concise status update for ingests maintained by the Atmospheric Radiation Measurement (ARM) Climate Research Facility. The report is divided into the following sections: (1) new ingests for which development has begun, (2) progress on existing ingests, (3) future ingests that have been recently approved, (4) other work that leads to an ingest, and (5) top requested ingests from the ARM Data Archive. New information is highlighted in blue text.

Clinical usefulness of the two-question assessment tool for depressive symptoms in Japanese patients with chronic obstructive pulmonary disease.

PubMed

Arimura, Yasuji; Yamazaki, Shin; Yanagi, Shigehisa; Matsumoto, Nobuhiro; Takegami, Misa; Hayashino, Yasuaki; Fukuhara, Shunichi; Nakazato, Masamitsu

2013-02-01

Depressive symptoms are highly prevalent in patients with chronic obstructive pulmonary disease (COPD) and have been associated with poor outcomes. Developing a concise questionnaire to measure depressive symptoms in COPD patients is needed in outpatient settings. We evaluated the clinical usefulness of a concise two-question instrument to assess depressive symptoms in patients with COPD. The study was conducted as a cross-sectional analysis in patients with COPD. All patients completed a self-reported questionnaire consisting of the two-question instrument, as well as a shortened version of the Center for Epidemiologic Studies Depression Scale (CESD-10) to measure depressive symptoms. Performance of the two-question instrument was evaluated using the results for CESD-10 as standard. We also measured patients' health-related quality of life using the Medical Outcomes Study 8-Item Short-Form Health Survey (SF-8) to determine whether the instrument was related to SF-8. Sensitivity of the two-question instrument in the detection of depressive symptoms was 73.3 % (95 % confidence interval [CI] 51-95.7), specificity was 73 % (95 % CI 58.7-87.3), and area under the receiver operating characteristics curve was 0.73 (95 % CI 0.59-0.87). When study patients were divided into two groups with a cutoff of 1 point on the two-question instrument, scores for all subscales of the SF-8 except "bodily pain" were significantly lower in patients with than without depressive symptoms. This concise two-question instrument is useful as assessment of depressive symptom in patients with COPD in busy outpatient settings.

Concise Review: Microfluidic Technology Platforms: Poised to Accelerate Development and Translation of Stem Cell-Derived Therapies

PubMed Central

Titmarsh, Drew M.; Chen, Huaying; Glass, Nick R.; Cooper-White, Justin J.

2014-01-01

Stem cells are a powerful resource for producing a variety of cell types with utility in clinically associated applications, including preclinical drug screening and development, disease and developmental modeling, and regenerative medicine. Regardless of the type of stem cell, substantial barriers to clinical translation still exist and must be overcome to realize full clinical potential. These barriers span processes including cell isolation, expansion, and differentiation; purification, quality control, and therapeutic efficacy and safety; and the economic viability of bioprocesses for production of functional cell products. Microfluidic systems have been developed for a myriad of biological applications and have the intrinsic capability of controlling and interrogating the cellular microenvironment with unrivalled precision; therefore, they have particular relevance to overcoming such barriers to translation. Development of microfluidic technologies increasingly utilizes stem cells, addresses stem cell-relevant biological phenomena, and aligns capabilities with translational challenges and goals. In this concise review, we describe how microfluidic technologies can contribute to the translation of stem cell research outcomes, and we provide an update on innovative research efforts in this area. This timely convergence of stem cell translational challenges and microfluidic capabilities means that there is now an opportunity for both disciplines to benefit from increased interaction. PMID:24311699

Debye-Waller Factor in Neutron Scattering by Ferromagnetic Metals

NASA Astrophysics Data System (ADS)

Paradezhenko, G. V.; Melnikov, N. B.; Reser, B. I.

2018-04-01

We obtain an expression for the neutron scattering cross section in the case of an arbitrary interaction of the neutron with the crystal. We give a concise, simple derivation of the Debye-Waller factor as a function of the scattering vector and the temperature. For ferromagnetic metals above the Curie temperature, we estimate the Debye-Waller factor in the range of scattering vectors characteristic of polarized magnetic neutron scattering experiments. In the example of iron, we compare the results of harmonic and anharmonic approximations.

Insights, Pearls, and Guidance on Successfully Producing and Publishing Educational Research

PubMed Central

Romanelli, Frank

2016-01-01

It is the collaborative responsibility of authors, reviewers, and editors to produce high-quality manuscripts that advance knowledge and educational practice. Experience with manuscript submissions to the American Journal of Pharmaceutical Education reveal several areas for improvement that authors can make to increase their submission success rate during the review process. These improvements include research question justification, improved clarity and details regarding methodology, concise data and results, and a discussion that frames research findings in the context of what is already known. This paper summarizes common flaws we see in submitted manuscripts and makes suggestions on how to address these areas and improve publication success. PMID:27402978

Flowcharting with D-charts

NASA Technical Reports Server (NTRS)

Meyer, D.

1985-01-01

A D-Chart is a style of flowchart using control symbols highly appropriate to modern structured programming languages. The intent of a D-Chart is to provide a clear and concise one-for-one mapping of control symbols to high-level language constructs for purposes of design and documentation. The notation lends itself to both high-level and code-level algorithmic description. The various issues that may arise when representing, in D-Chart style, algorithms expressed in the more popular high-level languages are addressed. In particular, the peculiarities of mapping control constructs for Ada, PASCAL, FORTRAN 77, C, PL/I, Jovial J73, HAL/S, and Algol are discussed.

Flowcharting with D-charts

NASA Technical Reports Server (NTRS)

Meyer, D. D.

1985-01-01

A D-Chart is a style of flowchart using control symbols highly appropriate to modern structured programming languages. The intent of a D-Chart is to provide a clear and concise one-for-one mapping of control symbols to high-level language constructs for purposes of design and documentation. The notation lends itself to both high-level and code-level algorithmic description. The various issues that may arise when representing, in D-Chart style, algorithms expressed in the more popular high-level languages are addressed. In particular, the peculiarities of mapping control constructs for Ada, PASCAL, FORTRAN 77, C, PL/I, Joviai J73, HAL/S, and Algol are discussed.

Magnetic resonance imaging of the pediatric neck: an overview.

PubMed

Shekdar, Karuna V; Mirsky, David M; Kazahaya, Ken; Bilaniuk, Larissa T

2012-08-01

Evaluation of neck lesions in the pediatric population can be a diagnostic challenge, for which magnetic resonance (MR) imaging is extremely valuable. This article provides an overview of the value and utility of MR imaging in the evaluation of pediatric neck lesions, addressing what the referring clinician requires from the radiologist. Concise descriptions and illustrations of MR imaging findings of commonly encountered pathologic entities in the pediatric neck, including abnormalities of the branchial apparatus, thyroglossal duct anomalies, and neoplastic processes, are given. An approach to establishing a differential diagnosis is provided, and critical points of information are summarized. Copyright © 2012 Elsevier Inc. All rights reserved.

Guidelines for Preparation of a Scientific Paper

PubMed Central

Kosiba, Margaret M.

1988-01-01

Even the experienced scientific writer may have difficulty transferring research results to clear, concise, publishable words. To assist the beginning scientific writer, guidelines are proposed that will provide direction for determining a topic, developing protocols, collecting data, using computers for analysis and word processing, incorporating copyediting notations, consulting scientific writing manuals, and developing sound writing habits. Guidelines for writing each section of a research paper are described to help the writer prepare the title page, introduction, materials and methods, results, and discussion sections of the paper, as well as the acknowledgments and references. Procedures for writing the first draft and subsequent revisions include a checklist of structural and stylistic problems and common errors in English usage. PMID:3339646

10 CFR 75.34 - Inventory change reports.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Transactions Reports (Inventory Change Reports), when appropriate, must be accompanied by Concise Notes... Commission, Division of Fuel Cycle Safety and Safeguards, Washington, DC 20555-0001. This Concise Note is... operational program for the facility, including particularly, but not exclusively, the schedule for taking...

10 CFR 75.34 - Inventory change reports.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Transactions Reports (Inventory Change Reports), when appropriate, must be accompanied by Concise Notes... Commission, Division of Fuel Cycle Safety and Safeguards, Washington, DC 20555-0001. This Concise Note is... operational program for the facility, including particularly, but not exclusively, the schedule for taking...

10 CFR 75.34 - Inventory change reports.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Transactions Reports (Inventory Change Reports), when appropriate, must be accompanied by Concise Notes... Commission, Division of Fuel Cycle Safety and Safeguards, Washington, DC 20555-0001. This Concise Note is... operational program for the facility, including particularly, but not exclusively, the schedule for taking...

10 CFR 75.34 - Inventory change reports.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Transactions Reports (Inventory Change Reports), when appropriate, must be accompanied by Concise Notes... Commission, Division of Fuel Cycle Safety and Safeguards, Washington, DC 20555-0001. This Concise Note is... operational program for the facility, including particularly, but not exclusively, the schedule for taking...

A concise synthesis of optically active solanacol, the germination stimulant for seeds of root parasitic weeds.

PubMed

Kumagai, Hiroshi; Fujiwara, Mami; Kuse, Masaki; Takikawa, Hirosato

2015-01-01

Solanacol, isolated from tobacco (Nicotiana tabacum L.), is a germination stimulant for seeds of root parasitic weeds. A concise synthesis of optically active solanacol has been achieved by employing enzymatic resolution as a key step.

A randomized trial comparing concise and standard consent forms in the START trial

PubMed Central

Touloumi, Giota; Walker, A. Sarah; Smolskis, Mary; Sharma, Shweta; Babiker, Abdel G.; Pantazis, Nikos; Tavel, Jorge; Florence, Eric; Sanchez, Adriana; Hudson, Fleur; Papadopoulos, Antonios; Emanuel, Ezekiel; Clewett, Megan; Munroe, David; Denning, Eileen

2017-01-01

Background Improving the effectiveness and efficiency of research informed consent is a high priority. Some express concern about longer, more complex, written consent forms creating barriers to participant understanding. A recent meta-analysis concluded that randomized comparisons were needed. Methods We conducted a cluster-randomized non-inferiority comparison of a standard versus concise consent form within a multinational trial studying the timing of starting antiretroviral therapy in HIV+ adults (START). Interested sites were randomized to standard or concise consent forms for all individuals signing START consent. Participants completed a survey measuring comprehension of study information and satisfaction with the consent process. Site personnel reported usual site consent practices. The primary outcome was comprehension of the purpose of randomization (pre-specified 7.5% non-inferiority margin). Results 77 sites (2429 participants) were randomly allocated to use standard consent and 77 sites (2000 participants) concise consent, for an evaluable cohort of 4229. Site and participant characteristics were similar for the two groups. The concise consent was non-inferior to the standard consent on comprehension of randomization (80.2% versus 82%, site adjusted difference: 0.75% (95% CI -3.8%, +5.2%)); and the two groups did not differ significantly on total comprehension score, satisfaction, or voluntariness (p>0.1). Certain independent factors, such as education, influenced comprehension and satisfaction but not differences between consent groups. Conclusions An easier to read, more concise consent form neither hindered nor improved comprehension of study information nor satisfaction with the consent process among a large number of participants. This supports continued efforts to make consent forms more efficient. Trial registration Informed consent substudy was registered as part of START study in clinicaltrials.gov #NCT00867048, and EudraCT # 2008-006439-12 PMID:28445471

Personality, Organizational Orientations and Self-Reported Learning Outcomes

ERIC Educational Resources Information Center

Bamber, David; Castka, Pavel

2006-01-01

Purpose: To identify competencies connecting personality, organizational orientations and self-reported learning outcomes (as measured by concise Likert-type scales), for individuals who are learning for their organizations. Design/methodology/approach: Five concise factor scales were constructed to represent aspects of personality. Three further…

A General, Concise Strategy that Enables Collective Total Syntheses of over 50 Protoberberine and Five Aporhoeadane Alkaloids within Four to Eight Steps.

PubMed

Zhou, Shiqiang; Tong, Rongbiao

2016-05-17

A concise, catalytic, and general strategy that allowed efficient total syntheses of 22 natural 13-methylprotoberberines within four steps for each molecule is reported. This synthesis represents the most efficient and shortest route to date, featuring three catalytic processes: CuI-catalyzed redox-A(3) reaction, Pd-catalyzed reductive carbocyclization, and PtO2 -catalyzed hydrogenation. Importantly, this new strategy to the tetracyclic framework has also been applied to the collective concise syntheses of >30 natural protoberberines (without 13-methyl group) and five aporhoeadane alkaloids. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Identifying Core Profiles in Attitudes toward School Violence

ERIC Educational Resources Information Center

Frisby, Craig L.; Kim, Se-Kang; Wolfmeyer, Mary Anne

2005-01-01

Focus group methods for studying opinions and perceptions of school violence are effective for understanding differences among individuals, but cannot report these differences in a concise manner. Traditional quantitative methods for analyzing data from school violence perception surveys allow for the concise reporting of data, but cannot…

A Dodecalogue of Basic Didactics from Applications of Abstract Differential Geometry to Quantum Gravity

NASA Astrophysics Data System (ADS)

Raptis, Ioannis

2007-12-01

We summarize the twelve most important in our view novel concepts that have arisen, based on results that have been obtained, from various applications of Abstract Differential Geometry (ADG) to Quantum Gravity (QG). The present document may be used as a concise, yet informal, discursive and peripatetic conceptual guide- cum-terminological glossary to the voluminous technical research literature on the subject. In a bonus section at the end, we dwell on the significance of introducing new conceptual terminology in future QG research by means of ‘poetic language’.

Effects of Physical Exercise on Cognitive Functioning and Wellbeing: Biological and Psychological Benefits

PubMed Central

Mandolesi, Laura; Polverino, Arianna; Montuori, Simone; Foti, Francesca; Ferraioli, Giampaolo; Sorrentino, Pierpaolo; Sorrentino, Giuseppe

2018-01-01

Much evidence shows that physical exercise (PE) is a strong gene modulator that induces structural and functional changes in the brain, determining enormous benefit on both cognitive functioning and wellbeing. PE is also a protective factor for neurodegeneration. However, it is unclear if such protection is granted through modifications to the biological mechanisms underlying neurodegeneration or through better compensation against attacks. This concise review addresses the biological and psychological positive effects of PE describing the results obtained on brain plasticity and epigenetic mechanisms in animal and human studies, in order to clarify how to maximize the positive effects of PE while avoiding negative consequences, as in the case of exercise addiction. PMID:29755380

Concise Review: Developing Best‐Practice Models for the Therapeutic Use of Extracellular Vesicles

PubMed Central

Reiner, Agnes T.; Witwer, Kenneth W.; van Balkom, Bas W.M.; de Beer, Joel; Brodie, Chaya; Corteling, Randolph L.; Gabrielsson, Susanne; Gimona, Mario; Ibrahim, Ahmed G.; de Kleijn, Dominique; Lai, Charles P.; Lötvall, Jan; del Portillo, Hernando A.; Reischl, Ilona G.; Riazifar, Milad; Salomon, Carlos; Tahara, Hidetoshi; Toh, Wei Seong; Wauben, Marca H.M.; Yang, Vicky K.; Yang, Yijun; Yeo, Ronne Wee Yeh; Yin, Hang; Giebel, Bernd

2017-01-01

Abstract Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell‐related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened a Workshop on this topic to discuss the opportunities and challenges associated with development of EV‐based therapeutics at the preclinical and clinical levels. This review outlines topic‐specific action items that, if addressed, will enhance the development of best‐practice models for EV therapies. Stem Cells Translational Medicine 2017;6:1730–1739 PMID:28714557

The evolution of infectious agents in relation to sex in animals and humans: brief discussions of some individual organisms

PubMed Central

Reed, David L.; Currier, Russell W.; Walton, Shelley F.; Conrad, Melissa; Sullivan, Steven A.; Carlton, Jane M.; Read, Timothy D.; Severini, Alberto; Tyler, Shaun; Eberle, R.; Johnson, Welkin E.; Silvestri, Guido; Clarke, Ian N.; Lagergård, Teresa; Lukehart, Sheila A.; Unemo, Magnus; Shafer, William M.; Beasley, R. Palmer; Bergström, Tomas; Norberg, Peter; Davison, Andrew J.; Sharp, Paul M.; Hahn, Beatrice H.; Blomberg, Jonas

2013-01-01

The following series of concise summaries addresses the evolution of infectious agents in relation to sex in animals and humans from the perspective of three specific questions: (1) what have we learned about the likely origin and phylogeny, up to the establishment of the infectious agent in the genital econiche, including the relative frequency of its sexual transmission; (2) what further research is needed to provide additional knowledge on some of these evolutionary aspects; and (3) what evolutionary considerations might aid in providing novel approaches to the more practical clinical and public health issues facing us currently and in the future? PMID:21824167

Delaware Technical & Community College's response to the critical shortage of Delaware secondary science teachers

NASA Astrophysics Data System (ADS)

Campbell, Nancy S.

This executive position paper examines the critical shortage of Delaware high school science teachers and Delaware Technical & Community College's possible role in addressing this shortage. A concise analysis of economic and political implications of the science teacher shortage is presented. The following topics were researched and evaluated: the specific science teacher needs for Delaware school districts; the science teacher education program offerings at Delaware universities and colleges; the Alternative Route to Teacher Certification (ARTC); and the state of Delaware's scholarship response to the need. Recommendations for Delaware Tech's role include the development and implementation of two new Associate of Arts of Teaching programs in physics secondary science education and chemistry secondary science education.

Applying the One Health Concept to Mycobacterial Research - Overcoming Parochialism.

PubMed

Thirunavukkarasu, S; Plain, K M; de Silva, K; Marais, B J; Whittington, R J

2017-09-01

Mycobacterial infections remain a public health problem. Historically important, globally ubiquitous and with a wide host range, we are still struggling to control mycobacterial infections in humans and animals. While previous reviews have focused on individual mycobacterial infections in either humans or animals, a comprehensive review of the zoonotic aspect of mycobacteria in the context of the One Health initiative is lacking. With the purpose of providing a concise and comprehensive resource, we have collated literature to address the zoonotic potential of different mycobacterial species and elaborate on the necessity for an inter-sectorial approach to attain a new vision to combat mycobacterial infections. © 2017 Blackwell Verlag GmbH.

Concise total syntheses of (+/-)-strychnine and (+/-)-akuammicine.

PubMed

Sirasani, Gopal; Paul, Tapas; Dougherty, William; Kassel, Scott; Andrade, Rodrigo B

2010-05-21

Concise total syntheses of Strychnos alkaloids strychnine (1) and akuammicine (2) have been realized in 13 and 6 operations, respectively. Key steps include (1) the vinylogous Mannich reaction; (2) a novel, sequential one-pot spirocyclization/intramolecular aza-Baylis-Hillman reaction; and (3) a Heck cyclization. The synthesis of 1 proceeds via the Wieland-Gumlich aldehyde (26).

The Dirty Dozen: A Concise Measure of the Dark Triad

ERIC Educational Resources Information Center

Jonason, Peter K.; Webster, Gregory D.

2010-01-01

There has been an exponential increase of interest in the dark side of human nature during the last decade. To better understand this dark side, the authors developed and validated a concise, 12-item measure of the Dark Triad: narcissism, psychopathy, Machiavellianism. In 4 studies involving 1,085 participants, they examined its structural…

Partnerships for affordable and equitable disaster insurance

NASA Astrophysics Data System (ADS)

Mysiak, J.; Pérez-Blanco, C. D.

2015-08-01

Extreme events are becoming more frequent and intense, inflating the economic damages and social hardship set-off by natural catastrophes. Amidst budgetary cuts, there is a growing concern on societies' ability to design solvent disaster recovery strategies, while addressing equity and affordability concerns. The participation of private sector along with public one through Public-Private Partnerships (PPPs) has gained on importance as a means to address these seemingly conflicting objectives through the provision of (catastrophic) natural hazard insurance. This is the case of many OECD countries, notably some EU Member States such as the United Kingdom and Spain. The EU legislator has adapted to this new scenario and recently produced major reforms in the legislation and regulation that govern the framework in which PPPs for (catastrophic) natural hazard insurance develop. This paper has a dual objective: (1) review the complex legal background that rules the provision of insurance against natural catastrophes in the EU after these major reforms, (2) assess the implications of the reforms and offer concise Policy Guiding Principles.

Geographic variation in opinions on climate change at state and local scales in the USA

NASA Astrophysics Data System (ADS)

Howe, Peter D.; Mildenberger, Matto; Marlon, Jennifer R.; Leiserowitz, Anthony

2015-06-01

Addressing climate change in the United States requires enactment of national, state and local mitigation and adaptation policies. The success of these initiatives depends on public opinion, policy support and behaviours at appropriate scales. Public opinion, however, is typically measured with national surveys that obscure geographic variability across regions, states and localities. Here we present independently validated high-resolution opinion estimates using a multilevel regression and poststratification model. The model accurately predicts climate change beliefs, risk perceptions and policy preferences at the state, congressional district, metropolitan and county levels, using a concise set of demographic and geographic predictors. The analysis finds substantial variation in public opinion across the nation. Nationally, 63% of Americans believe global warming is happening, but county-level estimates range from 43 to 80%, leading to a diversity of political environments for climate policy. These estimates provide an important new source of information for policymakers, educators and scientists to more effectively address the challenges of climate change.

Nocturia × disturbed sleep: a review.

PubMed

Furtado, Daniele; Hachul, Helena; Andersen, Monica L; Castro, Rodrigo A; Girão, Manoel B; Tufik, Sergio

2012-03-01

In this article, we provide a concise review of the literature on nocturia and its interference with sleep and, consequently, on quality of life. There are few studies addressing the possible influences of nocturia on sleep disruption. Nocturia is a potential contributor to sleep disorders because affected individuals experience nonrestorative sleep due to frequent interruptions. We also attempted to determine whether individuals with nocturia wake to urinate or, alternately, urinate because they are awake. This review attempts to outline this specific association by examining the possible interactions with other medical conditions and the pathophysiology and prevalence. Most studies have observed a higher prevalence among women; however, the impact on quality of life is higher in men. Nocturia is not necessarily associated with natural aging. The exploration of these topics provides information to clarify the implications of nocturia on sleep, sleep disruption, and other related consequences. Additional evidence is still required to address the question of whether nocturia leads to disordered sleep or whether disordered sleep leads to nocturia.

Concise solid-phase synthesis of inverse poly(amidoamine) dendrons using AB2 building blocks.

PubMed

Huang, Adela Ya-Ting; Tsai, Ching-Hua; Chen, Hsing-Yin; Chen, Hui-Ting; Lu, Chi-Yu; Lin, Yu-Ting; Kao, Chai-Lin

2013-06-28

A concise solid-phase synthesis of inverse poly(amidoamine) dendrons was developed. Upon introduction of AB2-type monomers, each dendron generation was constructed via one reaction. G2 to G5 dendrons were constructed in a peptide synthesizer in 93%, 89%, 82%, and 78% yields, respectively, within 5 days.

The Affective Reactivity Index: A Concise Irritability Scale for Clinical and Research Settings

ERIC Educational Resources Information Center

Stringaris, Argyris; Goodman, Robert; Ferdinando, Sumudu; Razdan, Varun; Muhrer, Eli; Leibenluft, Ellen; Brotman, Melissa A.

2012-01-01

Background: Irritable mood has recently become a matter of intense scientific interest. Here, we present data from two samples, one from the United States and the other from the United Kingdom, demonstrating the clinical and research utility of the parent- and self-report forms of the Affective Reactivity Index (ARI), a concise dimensional measure…

Synthetic study toward ecteinascidin 743: concise construction of the diazabicyclo[3.3.1]nonane skeleton and assembly of the pentacyclic core.

PubMed

Enomoto, Taro; Yasui, Yoshizumi; Takemoto, Yoshiji

2010-07-16

Synthesis of the pentacyclic core of ecteinascidin 743 is described. This synthesis features concise construction of the diazabicyclo[3.3.1]nonane skeleton using gold(I)-catalyzed one-pot keto amide formation, acid-promoted enamide formation, and oxidative Friedel-Crafts cyclization as the key steps.

Calculation method for laser radar cross sections of rotationally symmetric targets.

PubMed

Cao, Yunhua; Du, Yongzhi; Bai, Lu; Wu, Zhensen; Li, Haiying; Li, Yanhui

2017-07-01

The laser radar cross section (LRCS) is a key parameter in the study of target scattering characteristics. In this paper, a practical method for calculating LRCSs of rotationally symmetric targets is presented. Monostatic LRCSs for four kinds of rotationally symmetric targets (cone, rotating ellipsoid, super ellipsoid, and blunt cone) are calculated, and the results verify the feasibility of the method. Compared with the results for the triangular patch method, the correctness of the method is verified, and several advantages of the method are highlighted. For instance, the method does not require geometric modeling and patch discretization. The method uses a generatrix model and double integral, and its calculation is concise and accurate. This work provides a theory analysis for the rapid calculation of LRCS for common basic targets.

A predictor-corrector scheme for vortex identification

NASA Technical Reports Server (NTRS)

Singer, Bart A.; Banks, David C.

1994-01-01

A new algorithm for identifying and characterizing vortices in complex flows is presented. The scheme uses both the vorticity and pressure fields. A skeleton line along the center of a vortex is produced by a two-step predictor-corrector scheme. The technique uses the vector field to move in the direction of the skeleton line and the scalar field to correct the location in the plane perpendicular to the skeleton line. A general vortex cross section can be concisely defined with five parameters at each point along the skeleton line. The details of the method and examples of its use are discussed.

Penetration of nanoparticles and nanomaterials in the skin: fiction or reality?

PubMed

Baroli, Biancamaria

2010-01-01

The advent of nanotechnological products in the market, while holding great promise, is raising concerns in consumers. Therefore, this contribution will attempt to compare different particulate formulations and to answer whether their passive penetration into, and potential permeation through the skin may be possible or not. To this end, skin structure, composition, and penetration paths will be concisely reviewed. Parameters generally cited to affect skin absorption will be resumed and commented on from the perspective of potentially penetrating nanosized agents. These sections will provide the basis to understand what is fiction and what is reality.

Challenges and Developments in the Assessment of (Mal)adaptive Personality and Pathological States in Older Adults.

PubMed

Rossi, Gina; Videler, Arjan; van Alphen, S P J

2018-04-01

Since older adults often show an atypical presentation of (mal)adaptive personality traits and pathological states, the articles in this special issue will concisely discuss some perennial issues in clinical assessment in older adults and thus outline the main challenges this domain faces. By bringing empirical work and meta-analytic studies from leading scholars in the field of geropsychology, the articles will also address these challenges by reporting the latest developments in the field. This way, we hope to reshape the way clinicians and researchers assess (mal)adaptive personality and pathological states in older adults into a more reliable and valid assessment method that integrates the specific biopsychosocial context of older age.

A CLINICIAN'S GUIDE TO X-LINKED HYPOPHOSPHATEMIA

PubMed Central

Carpenter, Thomas O.; Imel, Erik A.; Holm, Ingrid A.; Jan de Beur, Suzanne M.; Insogna, Karl L.

2011-01-01

X-linked hypophosphatemia (XLH) is the prototypic disorder of renal phosphate wasting, and the most common form of heritable rickets. Physicians, patients, and XLH support groups have all expressed concerns about the dearth of information about this disease and the lack of treatment guidelines which frequently lead to missed diagnoses or mismanagement. This perspective addresses the recommendation by conferees for the dissemination of concise and accessible treatment guidelines for clinicians arising from the “Advances in Rare Bone Diseases Scientific Conference,” held at the National Institutes of Health in October 2008. We briefly review the clinical and pathophysiologic features of the disorder, and offer this guide in response to the conference recommendation, base on our collective accumulated experience in the management of this complex disorder. PMID:21538511

Users Guide on Scaled CMOS Reliability: NASA Electronic Parts and Packaging (NEPP) Program Office of Safety and Mission Assurance

NASA Technical Reports Server (NTRS)

White, Mark; Cooper, Mark; Johnston, Allan

2011-01-01

Reliability of advanced CMOS technology is a complex problem that is usually addressed from the standpoint of specific failure mechanisms rather than overall reliability of a finished microcircuit. A detailed treatment of CMOS reliability in scaled devices can be found in Ref. 1; it should be consulted for a more thorough discussion. The present document provides a more concise treatment of the scaled CMOS reliability problem, emphasizing differences in the recommended approach for these advanced devices compared to that of less aggressively scaled devices. It includes specific recommendations that can be used by flight projects that use advanced CMOS. The primary emphasis is on conventional memories, microprocessors, and related devices.

The Concise Guide to PHARMACOLOGY 2015/16: Overview.

PubMed

Alexander, Stephen Ph; Kelly, Eamonn; Marrion, Neil; Peters, John A; Benson, Helen E; Faccenda, Elena; Pawson, Adam J; Sharman, Joanna L; Southan, Christopher; Buneman, O Peter; Catterall, William A; Cidlowski, John A; Davenport, Anthony P; Fabbro, Doriano; Fan, Grace; McGrath, John C; Spedding, Michael; Davies, Jamie A

2015-12-01

The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13347/full. This compilation of the major pharmacological targets is divided into eight areas of focus: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed version of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and GRAC and provides a permanent, citable, point-in-time record that will survive database updates. © 2015 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society.

Concise, Stereocontrolled Synthesis of the Citrinadin B Core Architecture

PubMed Central

Guerrero, Carlos A.; Sorensen, Erik J.

2011-01-01

A concise, stereocontrolled synthesis of the citrinadin B core architecture from scalemic, readily available starting materials is disclosed. Highlights include ready access to both cyclic tryptophan tautomer and TRANS-2,6-disubstituted piperidine fragments, an efficient, stereoretentive mixed Claisen acylation for the coupling of these halves, and further diastereoselective carbonyl addition and oxidative rearrangement for assembly of the core. PMID:21894952

Computer-Aided Characterization and Diagnosis of Diffuse Liver Diseases Based on Ultrasound Imaging: A Review.

PubMed

Bharti, Puja; Mittal, Deepti; Ananthasivan, Rupa

2016-04-19

Diffuse liver diseases, such as hepatitis, fatty liver, and cirrhosis, are becoming a leading cause of fatality and disability all over the world. Early detection and diagnosis of these diseases is extremely important to save lives and improve effectiveness of treatment. Ultrasound imaging, a noninvasive diagnostic technique, is the most commonly used modality for examining liver abnormalities. However, the accuracy of ultrasound-based diagnosis depends highly on expertise of radiologists. Computer-aided diagnosis systems based on ultrasound imaging assist in fast diagnosis, provide a reliable "second opinion" for experts, and act as an effective tool to measure response of treatment on patients undergoing clinical trials. In this review, we first describe appearance of liver abnormalities in ultrasound images and state the practical issues encountered in characterization of diffuse liver diseases that can be addressed by software algorithms. We then discuss computer-aided diagnosis in general with features and classifiers relevant to diffuse liver diseases. In later sections of this paper, we review the published studies and describe the key findings of those studies. A concise tabular summary comparing image database, features extraction, feature selection, and classification algorithms presented in the published studies is also exhibited. Finally, we conclude with a summary of key findings and directions for further improvements in the areas of accuracy and objectiveness of computer-aided diagnosis. © The Author(s) 2016.

Lectures on Kähler Geometry - Series: London Mathematical Society Student Texts (No. 69)

NASA Astrophysics Data System (ADS)

Moroianu, Andrei

2004-03-01

Kähler geometry is a beautiful and intriguing area of mathematics, of substantial research interest to both mathematicians and physicists. This self-contained graduate text provides a concise and accessible introduction to the topic. The book begins with a review of basic differential geometry, before moving on to a description of complex manifolds and holomorphic vector bundles. Kähler manifolds are discussed from the point of view of Riemannian geometry, and Hodge and Dolbeault theories are outlined, together with a simple proof of the famous Kähler identities. The final part of the text studies several aspects of compact Kähler manifolds: the Calabi conjecture, Weitzenböck techniques, Calabi Yau manifolds, and divisors. All sections of the book end with a series of exercises and students and researchers working in the fields of algebraic and differential geometry and theoretical physics will find that the book provides them with a sound understanding of this theory. The first graduate-level text on Kähler geometry, providing a concise introduction for both mathematicians and physicists with a basic knowledge of calculus in several variables and linear algebra Over 130 exercises and worked examples Self-contained and presents varying viewpoints including Riemannian, complex and algebraic

Concise Review: Mesenchymal Stem Cells for Functional Cartilage Tissue Engineering: Taking Cues from Chondrocyte‐Based Constructs

PubMed Central

Tan, Andrea R.

2017-01-01

Abstract Osteoarthritis, the most prevalent form of joint disease, afflicts 9% of the U.S. population over the age of 30 and costs the economy nearly $100 billion annually in healthcare and socioeconomic costs. It is characterized by joint pain and dysfunction, though the pathophysiology remains largely unknown. Due to its avascular nature and limited cellularity, articular cartilage exhibits a poor intrinsic healing response following injury. As such, significant research efforts are aimed at producing engineered cartilage as a cell‐based approach for articular cartilage repair. However, the knee joint is mechanically demanding, and during injury, also a milieu of harsh inflammatory agents. The unforgiving mechano‐chemical environment requires tissue replacements that are capable of bearing such burdens. The use of mesenchymal stem cells (MSCs) for cartilage tissue engineering has emerged as a promising cell source due to their ease of isolation, capacity to readily expand in culture, and ability to undergo lineage‐specific differentiation into chondrocytes. However, to date, very few studies utilizing MSCs have successfully recapitulated the structural and functional properties of native cartilage, exposing the difficult process of uniformly differentiating stem cells into desired cell fates and maintaining the phenotype during in vitro culture and after in vivo implantation. To address these shortcomings, here, we present a concise review on modulating stem cell behavior, tissue development and function using well‐developed techniques from chondrocyte‐based cartilage tissue engineering. Stem Cells Translational Medicine 2017;6:1295–1303 PMID:28177194

A Summary of Best Management Practices for Nonpoint Source Pollution

DTIC Science & Technology

1992-08-01

200-1, Environmental Protection and Enhancement, requies that NPS pollution be minimized and that Army installations and major commands comply with...Federal and state regula- tions. However, environmental managers and engineers have no concise summary of alterna- tives available for NPS pollution... environmental managers and engineers have no concise summary of alternatives available for NPS pollution control. This report presents a range of

Analysis of the Browns Ferry Unit 3 irradiation experiments. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Simmons, G.L.

1984-11-01

The results of the analysis of two experiments performed at the Browns Ferry-3 reactor are presented. These calculations utilize state-of-the-art neutron transport techniques and a new neutron cross-section library that has been developed for LWR applications. The calculations agree well with the experimental data obtained in irradiations inside the reactor vessel. For the measurements performed in the reactor cavity, the calculations agree well at the reactor midplane. Accurate determination of the axial distribution of the neutron fluence in the reactor cavity depends on having a concise representation of the axial-void distribution in the core. Detailed data are presented describing themore » procedures used in the generation of the new cross-section library that has been named SAILOR. This library is available from the Radiation-Shielding Information Center.« less

Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (edited by Gerhard Michal)

NASA Astrophysics Data System (ADS)

Voige, Reviewed By William H.

2000-02-01

For decades, a wall chart detailing living organisms' metabolic pathways has been a fixture in many classrooms and laboratories where biochemistry is taught. One of the most popular of those charts first appeared 30 years ago. Now its editor, Gerhard Michal, has produced a book that summarizes metabolism (broadly defined) in graphical and textual formats. The book retains the elegance of the chart. Names of molecules are printed in a crisp, easy-to-read font, and structural formulas are shown with exemplary clarity. Color coding serves multiple purposes: to differentiate enzymes, substrates, cofactors, and effector molecules; to indicate in which group or groups of organisms a reaction has been observed; and to distinguish enzymatic reactions from regulatory effects. The primary advantage of presenting this information in book format is immediately apparent. A typical metabolic chart covers about 2 m2; the book has a total surface area nearly 10 times greater. The extra space is used to add explanatory text to the figures and to include many topics not covered by the traditional definition of metabolism. Examples include replication, transcription, translation, reaction mechanisms for proteolytic enzymes, and the role of chaperones in protein folding. Illustrating these topics is not as straightforward as delineating a metabolic pathway, but the author has done an admirable job of designing figures that clarify these and other aspects of biochemistry and complement the accompanying text. A potential deficiency of book format is the inability to clearly show links between different realms of metabolism: carbohydrate and amino acid pathways, for example. The book overcomes this problem in two ways. A diagrammatic overview of metabolism (with references to applicable sections of the book) is printed inside its front cover, and key compounds (pyruvate, for example) have a distinctive green background to provide a visual link between pathways. (The author compares this feature to the hyperlinks in an electronic document.) The book's index is comprehensive and useful. Entries for "phenylketonuria" and "sickle cell anemia", for example, lead to commendably concise summaries of these hereditary diseases (and the relevant metabolic pathway, in the former case). Looking up a specific molecule, however, is less helpful. The listing for fumarate hydratase, a citric acid cycle enzyme, directs the reader to the chapter on special bacterial metabolism but not to the section on the citric acid cycle itself. Literature references are included at the end of each section and are mainly from the 1990s, but they could be more useful. A long section on heme proteins, for example, concludes with eight citations, but their titles are not included, so it is impossible to determine what topic each one addresses. This book will be most useful to those with a good understanding of the fundamentals of biochemistry. Some of the information it presents could easily confuse less experienced readers. For example, it classifies selenocysteine as a standard amino acid in a figure but not in the accompanying text. In the diagram of anaerobic glycolysis, a double-headed arrow for the hexokinase reaction reinforces the frustratingly common student misperception that the phosphoryl group of glucose-6-phosphate can be used to phosphorylate ADP. Biochemical Pathways compiles a large amount of information in a single source. Its good index and clear, concise text and diagrams should make it a reliable way of gaining insight into many biochemical topics. With a price similar to that of most textbooks, it merits a place in the libraries of individuals and academic departments that teach biochemistry.

Two-Dimensional Transition Metal Oxide and Chalcogenide-Based Photocatalysts

NASA Astrophysics Data System (ADS)

Haque, Farjana; Daeneke, Torben; Kalantar-zadeh, Kourosh; Ou, Jian Zhen

2018-06-01

Two-dimensional (2D) transition metal oxide and chalcogenide (TMO&C)-based photocatalysts have recently attracted significant attention for addressing the current worldwide challenges of energy shortage and environmental pollution. The ultrahigh surface area and unconventional physiochemical, electronic and optical properties of 2D TMO&Cs have been demonstrated to facilitate photocatalytic applications. This review provides a concise overview of properties, synthesis methods and applications of 2D TMO&C-based photocatalysts. Particular attention is paid on the emerging strategies to improve the abilities of light harvesting and photoinduced charge separation for enhancing photocatalytic performances, which include elemental doping, surface functionalization as well as heterojunctions with semiconducting and conductive materials. The future opportunities regarding the research pathways of 2D TMO&C-based photocatalysts are also presented. [Figure not available: see fulltext.

Evolutionary and mechanistic theories of aging.

PubMed

Hughes, Kimberly A; Reynolds, Rose M

2005-01-01

Senescence (aging) is defined as a decline in performance and fitness with advancing age. Senescence is a nearly universal feature of multicellular organisms, and understanding why it occurs is a long-standing problem in biology. Here we present a concise review of both evolutionary and mechanistic theories of aging. We describe the development of the general evolutionary theory, along with the mutation accumulation, antagonistic pleiotropy, and disposable soma versions of the evolutionary model. The review of the mechanistic theories focuses on the oxidative stress resistance, cellular signaling, and dietary control mechanisms of life span extension. We close with a discussion of how an approach that makes use of both evolutionary and molecular analyses can address a critical question: Which of the mechanisms that can cause variation in aging actually do cause variation in natural populations?

Shared decision making: empowering the bedside nurse.

PubMed

Slack, Stephanie M; Boguslawski, Jean M; Eickhoff, Rachel M; Klein, Kristi A; Pepin, Teresa M; Schrandt, Kevin; Wise, Carrie A; Zylstra, Jody A

2005-12-01

Shared decision making is a process that has empowered specialty nurses at the Mayo Clinic in Rochester, MN, to solve a practice concern. Staff nurses recognized a lack of concise, collated information available that described what nurses need to know when caring for patients receiving chemotherapy. Many aspects of the administration process were knowledge and experience based and not easily retrievable. The Hematology/Oncology/Blood and Marrow Transplant Clinical Practice Committee identified this as a significant practice issue. Ideas were brainstormed regarding how to make the information available to nursing colleagues. The Chemotherapy Yellow Pages is a resource that was developed to facilitate the rapid retrieval of pertinent information for bedside nurses. The content of this article outlines a'model of shared decision making and the processes used to address and resolve the practice concern.

Big Data Analytics with Datalog Queries on Spark.

PubMed

Shkapsky, Alexander; Yang, Mohan; Interlandi, Matteo; Chiu, Hsuan; Condie, Tyson; Zaniolo, Carlo

2016-01-01

There is great interest in exploiting the opportunity provided by cloud computing platforms for large-scale analytics. Among these platforms, Apache Spark is growing in popularity for machine learning and graph analytics. Developing efficient complex analytics in Spark requires deep understanding of both the algorithm at hand and the Spark API or subsystem APIs (e.g., Spark SQL, GraphX). Our BigDatalog system addresses the problem by providing concise declarative specification of complex queries amenable to efficient evaluation. Towards this goal, we propose compilation and optimization techniques that tackle the important problem of efficiently supporting recursion in Spark. We perform an experimental comparison with other state-of-the-art large-scale Datalog systems and verify the efficacy of our techniques and effectiveness of Spark in supporting Datalog-based analytics.

Big Data Analytics with Datalog Queries on Spark

PubMed Central

Shkapsky, Alexander; Yang, Mohan; Interlandi, Matteo; Chiu, Hsuan; Condie, Tyson; Zaniolo, Carlo

2017-01-01

There is great interest in exploiting the opportunity provided by cloud computing platforms for large-scale analytics. Among these platforms, Apache Spark is growing in popularity for machine learning and graph analytics. Developing efficient complex analytics in Spark requires deep understanding of both the algorithm at hand and the Spark API or subsystem APIs (e.g., Spark SQL, GraphX). Our BigDatalog system addresses the problem by providing concise declarative specification of complex queries amenable to efficient evaluation. Towards this goal, we propose compilation and optimization techniques that tackle the important problem of efficiently supporting recursion in Spark. We perform an experimental comparison with other state-of-the-art large-scale Datalog systems and verify the efficacy of our techniques and effectiveness of Spark in supporting Datalog-based analytics. PMID:28626296

A concise and practical stereoselective synthesis of ipragliflozin L-proline

PubMed Central

Ma, Shuai; Liu, Zhenren; Pan, Jing; Zhang, Shunli

2017-01-01

A concise and practical stereoselective synthesis of ipragliflozin L-proline was presented starting from 2-[(5-iodo-2-fluorophenyl)methyl]-1-benzothiophene and 2,3,4,6-tetra-O-pivaloyl-α-D-glucopyranosyl bromide without catalyst via iodine–lithium–zinc exchange. The overall yield was 52% in three steps and the product purity was excellent. Two key diastereomers were prepared with efficient and direct access to the α-C-arylglucoside. PMID:28684985

Mental Representations Formed From Educational Website Formats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Elizabeth T. Cady; Kimberly R. Raddatz; Tuan Q. Tran

2006-10-01

The increasing popularity of web-based distance education places high demand on distance educators to format web pages to facilitate learning. However, limited guidelines exist regarding appropriate writing styles for web-based distance education. This study investigated the effect of four different writing styles on reader’s mental representation of hypertext. Participants studied hypertext written in one of four web-writing styles (e.g., concise, scannable, objective, and combined) and were then administered a cued association task intended to measure their mental representations of the hypertext. It is hypothesized that the scannable and combined styles will bias readers to scan rather than elaborately read, whichmore » may result in less dense mental representations (as identified through Pathfinder analysis) relative to the objective and concise writing styles. Further, the use of more descriptors in the objective writing style will lead to better integration of ideas and more dense mental representations than the concise writing style.« less

Modeling positional effects of regulatory sequences with spline transformations increases prediction accuracy of deep neural networks

PubMed Central

Avsec, Žiga; Cheng, Jun; Gagneur, Julien

2018-01-01

Abstract Motivation Regulatory sequences are not solely defined by their nucleic acid sequence but also by their relative distances to genomic landmarks such as transcription start site, exon boundaries or polyadenylation site. Deep learning has become the approach of choice for modeling regulatory sequences because of its strength to learn complex sequence features. However, modeling relative distances to genomic landmarks in deep neural networks has not been addressed. Results Here we developed spline transformation, a neural network module based on splines to flexibly and robustly model distances. Modeling distances to various genomic landmarks with spline transformations significantly increased state-of-the-art prediction accuracy of in vivo RNA-binding protein binding sites for 120 out of 123 proteins. We also developed a deep neural network for human splice branchpoint based on spline transformations that outperformed the current best, already distance-based, machine learning model. Compared to piecewise linear transformation, as obtained by composition of rectified linear units, spline transformation yields higher prediction accuracy as well as faster and more robust training. As spline transformation can be applied to further quantities beyond distances, such as methylation or conservation, we foresee it as a versatile component in the genomics deep learning toolbox. Availability and implementation Spline transformation is implemented as a Keras layer in the CONCISE python package: https://github.com/gagneurlab/concise. Analysis code is available at https://github.com/gagneurlab/Manuscript_Avsec_Bioinformatics_2017. Contact avsec@in.tum.de or gagneur@in.tum.de Supplementary information Supplementary data are available at Bioinformatics online. PMID:29155928

Rule-based modeling: a computational approach for studying biomolecular site dynamics in cell signaling systems

PubMed Central

Chylek, Lily A.; Harris, Leonard A.; Tung, Chang-Shung; Faeder, James R.; Lopez, Carlos F.

2013-01-01

Rule-based modeling was developed to address the limitations of traditional approaches for modeling chemical kinetics in cell signaling systems. These systems consist of multiple interacting biomolecules (e.g., proteins), which themselves consist of multiple parts (e.g., domains, linear motifs, and sites of phosphorylation). Consequently, biomolecules that mediate information processing generally have the potential to interact in multiple ways, with the number of possible complexes and post-translational modification states tending to grow exponentially with the number of binary interactions considered. As a result, only large reaction networks capture all possible consequences of the molecular interactions that occur in a cell signaling system, which is problematic because traditional modeling approaches for chemical kinetics (e.g., ordinary differential equations) require explicit network specification. This problem is circumvented through representation of interactions in terms of local rules. With this approach, network specification is implicit and model specification is concise. Concise representation results in a coarse graining of chemical kinetics, which is introduced because all reactions implied by a rule inherit the rate law associated with that rule. Coarse graining can be appropriate if interactions are modular, and the coarseness of a model can be adjusted as needed. Rules can be specified using specialized model-specification languages, and recently developed tools designed for specification of rule-based models allow one to leverage powerful software engineering capabilities. A rule-based model comprises a set of rules, which can be processed by general-purpose simulation and analysis tools to achieve different objectives (e.g., to perform either a deterministic or stochastic simulation). PMID:24123887

NMR Mapping of Protein Conformational Landscapes using Coordinated Behavior of Chemical Shifts upon Ligand Binding

PubMed Central

Cembran, Alessandro; Kim, Jonggul; Gao, Jiali; Veglia, Gianluigi

2014-01-01

Proteins exist as an ensemble of conformers that are distributed on free energy landscapes resembling folding funnels. While the most stable conformers populate low energy basins, protein function is often carried out through low-populated conformational states that occupy high energy basins. Ligand binding shifts the populations of these states, changing the distribution of these conformers. Understanding how the equilibrium among the states is altered upon ligand binding, interaction with other binding partners, and/or mutations and post-translational modifications is of critical importance for explaining allosteric signaling in proteins. Here, we propose a statistical analysis of the chemical shifts (CONCISE, COordiNated ChemIcal Shifts bEhavior) for the interpretation of protein conformational equilibria following linear trajectories of NMR chemical shifts. CONCISE enables one to quantitatively measure the population shifts associated with ligand titrations and estimate the degree of collectiveness of the protein residues’ response to ligand binding, giving a concise view of the structural transitions. The combination of CONCISE with thermocalorimetric and kinetic data allows one to depict a protein’s approximate conformational energy landscape. We tested this method with the catalytic subunit of cAMP-dependent protein kinase A, a ubiquitous enzyme that undergoes conformational transitions upon both nucleotide and pseudo-substrate binding. When complemented with chemical shift covariance analysis (CHESCA), this new method offers both collective response and residue-specific correlations for ligand binding to proteins. PMID:24604024

“Brevity is the Soul of Wit”: Use of a Stepwise Project to Teach Concise Scientific Writing

PubMed Central

Cyr, Nicole E.

2017-01-01

Skillful writing is essential for professionals in science and medicine. Consequently, many undergraduate institutions have adjusted their curriculum to include in-depth instruction and practice in writing for students majoring in the sciences. In neuroscience, students are often asked to write a laboratory report in the style of a primary scientific article or a term paper structured like a review article. Typically, students write section by section and build up to the final draft of a complete paper. In this way, students learn how to write a scientific paper. While learning to write such a paper is important, this is not the only type of written communication relevant to scientific careers. Here, I describe a stepwise writing project aimed to improve editing, succinctness, and the ability to synthesize the literature. Furthermore, I provide feedback from the students, and discuss the advantages and challenges of this project. PMID:29371841

A framework for treating DSM-5 alternative model for personality disorder features.

PubMed

Hopwood, Christopher J

2018-04-15

Despite its demonstrated empirical superiority over the DSM-5 Section 2 categorical model of personality disorders for organizing the features of personality pathology, limitations remain with regard to the translation of the DSM-5 Section 3 alternative model of personality disorders (AMPD) to clinical practice. The goal of this paper is to outline a general and preliminary framework for approaching treatment from the perspective of the AMPD. Specific techniques are discussed for the assessment and treatment of both Criterion A personality dysfunction and Criterion B maladaptive traits. A concise and step-by-step model is presented for clinical decision making with the AMPD, in the hopes of offering clinicians a framework for treating personality pathology and promoting further research on the clinical utility of the AMPD. Copyright © 2018 John Wiley & Sons, Ltd. Copyright © 2018 John Wiley & Sons, Ltd.

A national research agenda for public health services and systems.

PubMed

2012-05-01

The field of public health services and systems research (PHSSR) has emerged over the past decade to produce the evidence needed to address critical uncertainties about how best to organize, finance, and deliver effective public health strategies to all Americans. To advance these efforts, a national PHSSR research agenda-setting process was used to identify a broad inventory of information needs and uncertainties that public health stakeholders face in the domains of public health workforce, public health system structure and performance, public health financing, and public health information and technology. This paper presents the results of an expert review process used to transform the identified information needs into a concise set of research questions that can be pursued through new scientific inquiry in PHSSR. Established research frameworks were used to specify the contexts, mechanisms of action, and outcomes within the public health system that require further study. A total of 72 research questions were developed from the 113 original items in the PHSSR inventory of information needs. The questions include both persistent problems and newly emerging needs in public health practice and policy. The resulting research agenda provides a starting point for mobilizing the public health scientific enterprise around contemporary, high-priority uncertainties identified by broad cross sections of public health stakeholders. Regular updates to this agenda will be required to achieve continuous improvements in both the science and practice of public health. Copyright © 2012 American Journal of Preventive Medicine. All rights reserved.

Concise Review: The Periosteum: Tapping into a Reservoir of Clinically Useful Progenitor Cells

PubMed Central

Chang, Hana

2012-01-01

Elucidation of the periosteum and its regenerative potential has become a hot topic in orthopedics. Yet few review articles address the unique features of periosteum-derived cells, particularly in light of translational therapies and engineering solutions inspired by the periosteum's remarkable regenerative capacity. This review strives to define periosteum-derived cells in light of cumulative research in the field; in addition, it addresses clinical translation of current insights, hurdles to advancement, and open questions in the field. First, we examine the periosteal niche and its inhabitant cells and the key characteristics of these cells in the context of mesenchymal stem cells and their relevance for clinical translation. We compare periosteum-derived cells with those derived from the marrow niche in in vivo studies, addressing commonalities as well as features unique to periosteum cells that make them potentially ideal candidates for clinical application. Thereafter, we review the differentiation and tissue-building properties of periosteum cells in vitro, evaluating their efficacy in comparison with marrow-derived cells. Finally, we address a new concept of banking periosteum and periosteum-derived cells as a novel alternative to currently available autogenic umbilical blood and perinatal tissue sources of stem cells for today's population of aging adults who were “born too early” to bank their own perinatal tissues. Elucidating similarities and differences inherent to multipotent cells from distinct tissue niches and their differentiation and tissue regeneration capacities will facilitate the use of such cells and their translation to regenerative medicine. PMID:23197852

Concise Redox Deracemization of Secondary and Tertiary Amines with a Tetrahydroisoquinoline Core via a Nonenzymatic Process.

PubMed

Ji, Yue; Shi, Lei; Chen, Mu-Wang; Feng, Guang-Shou; Zhou, Yong-Gui

2015-08-26

A concise deracemization of racemic secondary and tertiary amines with a tetrahydroisoquinoline core has been successfully realized by orchestrating a redox process consisted of N-bromosuccinimide oxidation and iridum-catalyzed asymmetric hydrogenation. This compatible redox combination enables one-pot, single-operation deracemization to generate chiral 1-substituted 1,2,3,4-tetrahydroisoquinolines with up to 98% ee in 93% yield, offering a simple and scalable synthetic technique for chiral amines directly from racemic starting materials.

Concise chemical synthesis of a tetrasaccharide repeating unit of the O-antigen of Hafnia alvei 10457.

PubMed

Kumar, Rishi; Maulik, Prakas R; Misra, Anup Kumar

2008-08-01

Concise chemical synthesis of a tetrasaccharide repeating unit of the O-antigen of Hafnia alvei 10457 is reported. Construction of the tetrasaccharide as its 4-methoxyphenyl glycoside was achieved by condensation of less abundant monosaccharide units such as, D-galactofuranose, N-acetyl-D-galactosamine and N-acetylneuraminic acid. The synthetic strategy consists of the preparation of suitably protected required monosaccharide intermediates from the commercially available reducing sugars and high yielding glycosylation reactions.

Acting on Information: Representing Actions That Manipulate Information

NASA Technical Reports Server (NTRS)

Golden, Keith

1999-01-01

Information manipulation is the creation of new information based on existing information sources. This paper discusses problems that arise when planning for information manipulation, and proposes a novel action representation, called ADLIM, that addresses these problems, including: How to represent information in a way sufficient to express the effects of actions that modify the information. I present a simple, yet expressive, representation of information goals and effects that generalizes earlier work on representing sensing actions; How to concisely represent actions that copy information, or produce new information that is based on existing information sources. I show how this is a generalization of the frame problem, and present a solution based on generalized frame effects; and How to generate a pipeline of information-processing commands that will produce an output containing exactly the desired information. I present a new approach to goal regression.

A Concept Mapping Approach to Guide and Understand Dissemination and Implementation

PubMed Central

Green, Amy E.; Fettes, Danielle L.; Aarons, Gregory A.

2013-01-01

Many efforts to implement evidence-based programs do not reach their full potential or fail due to the variety of challenges inherent in dissemination and implementation. This article describes the use of concept mapping—a mixed method strategy—to study implementation of behavioral health innovations and evidence-based practice (EBP). The application of concept mapping to implementation research represents a practical and concise way to identify and quantify factors affecting implementation, develop conceptual models of implementation, target areas to address as part of implementation readiness and active implementation, and foster communication among stakeholders. Concept mapping is described and a case example is provided to illustrate its use in an implementation study. Implications for the use of concept mapping methods in both research and applied settings towards the dissemination and implementation of behavioral health services are discussed. PMID:22892987

A concept mapping approach to guide and understand dissemination and implementation.

PubMed

Green, Amy E; Fettes, Danielle L; Aarons, Gregory A

2012-10-01

Many efforts to implement evidence-based programs do not reach their full potential or fail due to the variety of challenges inherent in dissemination and implementation. This article describes the use of concept mapping-a mixed method strategy-to study implementation of behavioral health innovations and evidence-based practice (EBP). The application of concept mapping to implementation research represents a practical and concise way to identify and quantify factors affecting implementation, develop conceptual models of implementation, target areas to address as part of implementation readiness and active implementation, and foster communication among stakeholders. Concept mapping is described and a case example is provided to illustrate its use in an implementation study. Implications for the use of concept mapping methods in both research and applied settings towards the dissemination and implementation of behavioral health services are discussed.

Masters Thesis- Criticality Alarm System Design Guide with Accompanying Alarm System Development for the Radioisotope Production Laboratory in Richland, Washington

DOE Office of Scientific and Technical Information (OSTI.GOV)

Greenfield, Bryce A.

2009-12-01

A detailed instructional manual was created to guide criticality safety engineers through the process of designing a criticality alarm system (CAS) for Department of Energy (DOE) hazard class 1 and 2 facilities. Regulatory and technical requirements were both addressed. A list of design tasks and technical subtasks are thoroughly analyzed to provide concise direction for how to complete the analysis. An example of the application of the design methodology, the Criticality Alarm System developed for the Radioisotope Production Laboratory (RPL) of Richland, Washington is also included. The analysis for RPL utilizes the Monte Carlo code MCNP5 for establishing detector coveragemore » in the facility. Significant improvements to the existing CAS were made that increase the reliability, transparency, and coverage of the system.« less

The Empowerment of Patients with Mental Conditions and Addictions through e-Health.

PubMed

Nakos, Giorgos; Magita, Andrianna; Mechili, Aggelos E; Diomidous, Marianna; Mantas, John

2015-01-01

The aim of the current paper is the imparting of useful information to both patients and people in general regarding the development of mental conditions based on drug addictions, through e-health. It will provide all related information in order to achieve the empowerment of the selected sample regarding their conditions in terms of conceptualizing their health status. The general part is consisting of an overview on patient empowerment and e-health. The special part refers to the details of developing and presenting the above mentioned website. The information presented in the web site is addressing the general population and not only patients suffering a mental condition or addiction. The website contains the related articles and information obtained from the related bibliographical search. The main goal of the website is to impart concise information on the related issues.

Developing and Modifying Behavioral Coding Schemes in Pediatric Psychology: A Practical Guide

PubMed Central

McMurtry, C. Meghan; Chambers, Christine T.; Bakeman, Roger

2015-01-01

Objectives To provide a concise and practical guide to the development, modification, and use of behavioral coding schemes for observational data in pediatric psychology. Methods This article provides a review of relevant literature and experience in developing and refining behavioral coding schemes. Results A step-by-step guide to developing and/or modifying behavioral coding schemes is provided. Major steps include refining a research question, developing or refining the coding manual, piloting and refining the coding manual, and implementing the coding scheme. Major tasks within each step are discussed, and pediatric psychology examples are provided throughout. Conclusions Behavioral coding can be a complex and time-intensive process, but the approach is invaluable in allowing researchers to address clinically relevant research questions in ways that would not otherwise be possible. PMID:25416837

Integrated Science Assessment (ISA) for Sulfur Oxides ...

EPA Pesticide Factsheets

EPA announced the availability of the final report, Integrated Science Assessment (ISA) for Sulfur Oxides – Health Criteria final assessment. This report represents a concise synthesis and evaluation of the most policy-relevant science and will ultimately provide the scientific bases for EPA’s decision regarding whether the current standard for oxides of sulfur (SO2) sufficiently protects public health. The Integrated Plan for Review of the Primary NAAQS for SOx U.S. 2: EPA (2007) identifies key policy-relevant questions that provide a framework for this review of the scientific evidence. These questions frame the entire review of the NAAQS, and thus are informed by both science and policy considerations. The ISA organizes and presents the scientific evidence such that, when considered along with findings from risk analyses and policy considerations, will help the EPA address these questions in completing the NAAQS review.

Matrix of educational and training materials in remote sensing

NASA Technical Reports Server (NTRS)

Lindenlaub, J. C.; Lube, B. M.

1976-01-01

Remote sensing educational and training materials developed by LARS have been organized in a matrix format. Each row in the matrix represents a subject area in remote sensing and the columns represent different types of instructional materials. This format has proved to be useful for displaying in a concise manner the subject matter content, prerequisite requirements and technical depth of each instructional module in the matrix. A general description of the matrix is followed by three examples designed to illustrate how the matrix can be used to synthesize training programs tailored to meet the needs of individual students. A detailed description of each of the modules in the matrix is contained in a catalog section.

GLASS TRANSITION AND DEGREE OF CONVERSION OF A LIGHT-CURED ORTHODONTIC COMPOSITE

PubMed Central

Sostena, Michela M. D. S.; Nogueira, Renata A.; Grandini, Carlos R.; Moraes, João Carlos Silos

2009-01-01

Objective: This study evaluated the glass transition temperature (Tg) and degree of conversion (DC) of a light-cured (Fill Magic) versus a chemically cured (Concise) orthodontic composite. Material and Methods: Anelastic relaxation spectroscopy was used for the first time to determine the Tg of a dental composite, while the DC was evaluated by infrared spectroscopy. The light-cured composite specimens were irradiated with a commercial LED light-curing unit using different exposure times (40, 90 and 120 s). Results: Fill Magic presented lower Tg than Concise (35-84°C versus 135°C), but reached a higher DC. Conclusions: The results of this study suggest that Fill Magic has lower Tg than Concise due to its higher organic phase content, and that when this light-cured composite is used to bond orthodontic brackets, a minimum energy density of 7.8 J/cm2 is necessary to reach adequate conversion level and obtain satisfactory adhesion. PMID:20027428

How to ask and what to do: A guide for clinical inquiry and intervention regarding female sexual health after cancer

PubMed Central

Bober, Sharon L.; Reese, Jennifer B.; Barbera, Lisa; Bradford, Andrea; Carpenter, Kristen M.; Goldfarb, Shari; Carter, Jeanne

2016-01-01

Purpose of review As the number of female cancer survivors continues to grow, there is a growing need to bridge the gap between the high rate of women's cancer-related sexual dysfunction and the lack of attention and intervention available to the majority of survivors who suffer from sexual problems. Previously identified barriers that hinder communication for providers include limited time, lack of preparation, and a lack of patient resources and access to appropriate referral sources. Recent findings This paper brings together a recently developed model for approaching clinical inquiry about sexual health with a brief problem checklist that has been adapted for use for female cancer survivors, as well as practical evidence-based strategies on how to address concerns identified on the checklist. Examples of patient education sheets are provided, as well as strategies for building a referral network. Summary By providing access to a concise and efficient tool for clinical inquiry, as well as targeted material resources and practical health-promoting strategies based on recent evidence-based findings, we hope to begin eliminating the barriers that hamper oncology providers from addressing the topic of sexual/vaginal health after cancer. PMID:26716390

[An approach regarding the use of medication in biology textbooks as a strategy for health promotion].

PubMed

Corrêa, Anderson Domingues; Caminha, Juliana dos Reis; de Souza, Cristina Alves Magalhães; Alves, Luiz Anastacio

2013-10-01

The inappropriate use of medication represents a major threat to public health and drugs rank first among the agents causing intoxication in Brazil, ahead of poisons for rodents and insects, illegal drugs, pesticides, cleaning products and spoiled food. The National Curriculum of Secondary Education Parameters (PCN+) give major emphasis to health, since the reference to Drugs is mentioned repeatedly in the text. The scope of this research was to study the approaches to drug use in textbooks. For this purpose, eleven biology textbooks were analyzed, namely six single volumes and five with three volumes each, i.e. a total of twenty-one volumes. The rational use of medication should be considered an important topic for the promotion of health which affects all sectors of society and should be emphasized in basic education. In line with this idea and based on the results obtained, it is suggested that the textbooks analyzed should be adapted to the new legislation and content that addresses Rational Drug Use, thus meeting the recommendations of PCN+. In this context, the books should concisely address the following topics: self-medication, adherence to drug treatment, advertisements and reports on drugs, among others.

Quantum Optics in Phase Space

NASA Astrophysics Data System (ADS)

Schleich, Wolfgang P.

2001-04-01

Quantum Optics in Phase Space provides a concise introduction to the rapidly moving field of quantum optics from the point of view of phase space. Modern in style and didactically skillful, Quantum Optics in Phase Space prepares students for their own research by presenting detailed derivations, many illustrations and a large set of workable problems at the end of each chapter. Often, the theoretical treatments are accompanied by the corresponding experiments. An exhaustive list of references provides a guide to the literature. Quantum Optics in Phase Space also serves advanced researchers as a comprehensive reference book. Starting with an extensive review of the experiments that define quantum optics and a brief summary of the foundations of quantum mechanics the author Wolfgang P. Schleich illustrates the properties of quantum states with the help of the Wigner phase space distribution function. His description of waves ala WKB connects semi-classical phase space with the Berry phase. These semi-classical techniques provide deeper insight into the timely topics of wave packet dynamics, fractional revivals and the Talbot effect. Whereas the first half of the book deals with mechanical oscillators such as ions in a trap or atoms in a standing wave the second half addresses problems where the quantization of the radiation field is of importance. Such topics extensively discussed include optical interferometry, the atom-field interaction, quantum state preparation and measurement, entanglement, decoherence, the one-atom maser and atom optics in quantized light fields. Quantum Optics in Phase Space presents the subject of quantum optics as transparently as possible. Giving wide-ranging references, it enables students to study and solve problems with modern scientific literature. The result is a remarkably concise yet comprehensive and accessible text- and reference book - an inspiring source of information and insight for students, teachers and researchers alike.

An Ever Present Danger: A Concise History of British Military Operations on the North-West Frontier, 1849-1947 (Occasional Paper, Number 33)

DTIC Science & Technology

2010-06-01

belong almost exclusively to the trans-border Pashtun tribes. As Thomas H. Johnson and M. Chris Mason have pointed out; “The implica- 2 tions of the...Moreman, The Army in India and the Development of Frontier Warfare, 1849–1947 (London: Macmillan Press Ltd., 1998), 240. 4. Thomas H. Johnson and M...time they confronted the Pashtun tribes of the North-West Frontier. 14 Notes 1. Barbara D. Metcalf and Thomas R. Metcalf, A Concise History

Monte Carlo analysis of uncertainty propagation in a stratospheric model. 1: Development of a concise stratospheric model

NASA Technical Reports Server (NTRS)

Rundel, R. D.; Butler, D. M.; Stolarski, R. S.

1977-01-01

A concise model has been developed to analyze uncertainties in stratospheric perturbations, yet uses a minimum of computer time and is complete enough to represent the results of more complex models. The steady state model applies iteration to achieve coupling between interacting species. The species are determined from diffusion equations with appropriate sources and sinks. Diurnal effects due to chlorine nitrate formation are accounted for by analytic approximation. The model has been used to evaluate steady state perturbations due to injections of chlorine and NO(X).

Concise synthesis and PTP1B inhibitory activity of (R)- and (S)-dihydroresorcylide.

PubMed

Jiang, Cheng-Shi; Zhang, Li; Gong, Jing-Xu; Li, Jing-Ya; Yao, Li-Gong; Li, Jia; Guo, Yue-Wei

2017-12-01

The present study was designed to develop a concise synthetic route for macrolide, with the purpose of confirming the absolute configuration of natural dihydroresorcylide (1) and making it more easily accessible for biological evaluation. The absolute configuration of C-3 in natural 1 was revised to be R by comparison of the rotation sign of synthetic (R)- and (S)-1. The synthetic (R)-1 was found to be a novel highly specific PTP1B inhibitor with an IC 50 value of 17.06 μM.

Caesarean Section--A Density-Equalizing Mapping Study to Depict Its Global Research Architecture.

PubMed

Brüggmann, Dörthe; Löhlein, Lena-Katharina; Louwen, Frank; Quarcoo, David; Jaque, Jenny; Klingelhöfer, Doris; Groneberg, David A

2015-11-17

Caesarean section (CS) is a common surgical procedure. Although it has been performed in a modern context for about 100 years, there is no concise analysis of the international architecture of caesarean section research output available so far. Therefore, the present study characterizes the global pattern of the related publications by using the NewQIS (New Quality and Quantity Indices in Science) platform, which combines scientometric methods with density equalizing mapping algorithms. The Web of Science was used as a database. 12,608 publications were identified that originated from 131 countries. The leading nations concerning research activity, overall citations and country-specific h-Index were the USA and the United Kingdom. Relation of the research activity to epidemiologic data indicated that Scandinavian countries including Sweden and Finland were leading the field, whereas, in relation to economic data, countries such as Israel and Ireland led. Semi-qualitative indices such as country-specific citation rates ranked Sweden, Norway and Finland in the top positions. International caesarean section research output continues to grow annually in an era where caesarean section rates increased dramatically over the past decades. With regard to increasing employment of scientometric indicators in performance assessment, these findings should provide useful information for those tasked with the improvement of scientific achievements.

Portal vein thrombosis: a clinician-oriented and practical review.

PubMed

Handa, Pankaj; Crowther, Mark; Douketis, James D

2014-07-01

With advances in modern imaging techniques, portal vein thrombosis (PVT) is being increasingly diagnosed. It has a wide ranging clinical spectrum from being an asymptomatic state to a potentially life-threatening situation. It is not unusual to find it as an incidental finding in the abdominal imagings done for other reasons. It is commonly associated with cirrhosis and abdominal malignancies and also has a strong association with prothrombotic disorders. It is often difficult for the clinicians to decide whether PVT is acute or chronic. This poses great challenges to its management strategies that include anticoagulants, thrombolysis, and surgical options. Timely diagnosis and appropriate management have great bearings on its outcomes of morbidity and mortality. In this clinician-oriented review, we have provided a concise review of clinical aspects of PVT and discussed various management strategies while addressing the common questions that come to a physician's mind dealing with such a patient. © The Author(s) 2013.

Transition metal-catalyzed carboxylation reactions with carbon dioxide.

PubMed

Martin, Ruben; Tortajada, Andreu; Juliá-Hernández, Francisco; Borjesson, Marino; Moragas, Toni

2018-05-03

Driven by the inherent synthetic potential of CO2 as an abundant, inexpensive and renewable C1 chemical feedstock, the recent years have witnessed renewed interest in devising catalytic CO2 fixations into organic matter. Although the formation of C-C bonds via catalytic CO2 fixation remained rather limited for a long period of time, a close look into the recent literature data indicates that catalytic carboxylation reactions have entered a new era of exponential growth, evolving into a mature discipline that allows for streamlining the synthesis of carboxylic acids, building blocks of utmost relevance in industrial endeavours. These strategies have generally proven broadly applicability and convenient to perform. However, substantial challenges still need to be addressed reinforcing the need to cover metal-catalyzed carboxylation arena in a conceptual and concise manner, delineating the underlying new principles that are slowly emerging in this vibrant area of expertise. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Moles: Tool-Assisted Environment Isolation with Closures

NASA Astrophysics Data System (ADS)

de Halleux, Jonathan; Tillmann, Nikolai

Isolating test cases from environment dependencies is often desirable, as it increases test reliability and reduces test execution time. However, code that calls non-virtual methods or consumes sealed classes is often impossible to test in isolation. Moles is a new lightweight framework which addresses this problem. For any .NET method, Moles allows test-code to provide alternative implementations, given as .NET delegates, for which C# provides very concise syntax while capturing local variables in a closure object. Using code instrumentation, the Moles framework will redirect calls to provided delegates instead of the original methods. The Moles framework is designed to work together with the dynamic symbolic execution tool Pex to enable automated test generation. In a case study, testing code programmed against the Microsoft SharePoint Foundation API, we achieved full code coverage while running tests in isolation without an actual SharePoint server. The Moles framework integrates with .NET and Visual Studio.

Diabetes and Ramadan: A concise and practical update

PubMed Central

Ahmed, Mohamed H.; Husain, Nazik Elmalaika; Elmadhoun, Wadie M.; Noor, Sufian K.; Khalil, Abbas A.; Almobarak, Ahmed O.

2017-01-01

Despite the fact that the month of Ramadan includes 29–30 days and the duration of fasting for each day can last for between 12 and 16 h, it was estimated that a large number of individuals with diabetes do fast during Ramadan. In light of recent advancement of new pharmacological agents, drugs such as vildagliptin, sitagliptin, and liraglutide were found to be safe to use during this month of fasting. These therapeutic agents can also be used in combination with metformin. The use of sulfonylureas, in most of the recent guidelines about diabetes and Ramadan, seems not to gain much support due to the risk of hypoglycemia. In this review, we also addressed the use of insulin injection, insulin pump, and education before, during, and after Ramadan. Further research is needed to determine (i) the therapeutic benefit of new antidiabetic agents and (ii) the benefit of new technologies for the treatment of diabetes. PMID:29026740

Certification & validation of biosafety level-2 & biosafety level-3 laboratories in Indian settings & common issues

PubMed Central

Mourya, Devendra T.; Yadav, Pragya D.; Khare, Ajay; Khan, Anwar H.

2017-01-01

With increasing awareness regarding biorisk management worldwide, many biosafety laboratories are being setup in India. It is important for the facility users, project managers and the executing agencies to understand the process of validation and certification of such biosafety laboratories. There are some international guidelines available, but there are no national guidelines or reference standards available in India on certification and validation of biosafety laboratories. There is no accredited government/private agency available in India to undertake validation and certification of biosafety laboratories. Therefore, the reliance is mostly on indigenous experience, talent and expertise available, which is in short supply. This article elucidates the process of certification and validation of biosafety laboratories in a concise manner for the understanding of the concerned users and suggests the important parameters and criteria that should be considered and addressed during the laboratory certification and validation process. PMID:29434059

Structural equation modeling: building and evaluating causal models: Chapter 8

USGS Publications Warehouse

Grace, James B.; Scheiner, Samuel M.; Schoolmaster, Donald R.

2015-01-01

Scientists frequently wish to study hypotheses about causal relationships, rather than just statistical associations. This chapter addresses the question of how scientists might approach this ambitious task. Here we describe structural equation modeling (SEM), a general modeling framework for the study of causal hypotheses. Our goals are to (a) concisely describe the methodology, (b) illustrate its utility for investigating ecological systems, and (c) provide guidance for its application. Throughout our presentation, we rely on a study of the effects of human activities on wetland ecosystems to make our description of methodology more tangible. We begin by presenting the fundamental principles of SEM, including both its distinguishing characteristics and the requirements for modeling hypotheses about causal networks. We then illustrate SEM procedures and offer guidelines for conducting SEM analyses. Our focus in this presentation is on basic modeling objectives and core techniques. Pointers to additional modeling options are also given.

Integrated Science Assessment (ISA) for Carbon Monoxide ...

EPA Pesticide Factsheets

EPA announced that the First External Review Draft of the Integrated Science Assessment (ISA) for Carbon Monoxide (CO) and related Annexes was made available for independent peer review and public review. This draft ISA document represents a concise synthesis and evaluation of the most policy-relevant science and will ultimately provide the scientific bases for EPA's decision regarding whether the current standards for CO sufficiently protect public health and the environment. The Integrated Plan for Review of the NAAQS for CO {U.S. EPA, 2008 #8615} identifies key policy-relevant questions that provide a framework for this review of the scientific evidence. These questions frame the entire review of the NAAQS, and thus are informed by both science and policy considerations. The ISA organizes and presents the scientific evidence such that it, when considered along with findings from risk analyses and policy considerations, will help the EPA address these questions during the NAAQS review:

Developing standard operating procedures for gene drive research in disease vector mosquitoes.

PubMed

Adelman, Zach N; Pledger, David; Myles, Kevin M

2017-12-01

Numerous arthropod species represent potential targets for gene-drive-based population suppression or replacement, including those that transmit diseases, damage crops, or act as deleterious invasive species. Containment measures for gene drive research in arthropods have been discussed in the literature, but the importance of developing safe and effective standard operating procedures (SOPs) for these types of experiments has not been adequately addressed. Concisely written SOPs link safe work practices, containment measures, institutional training, and research-specific protocols. Here we discuss information to be considered by principal investigators, biosafety officers, and institutional biosafety committees as they work together to develop SOPs for experiments involving gene drive in arthropods, and describe various courses of action that can be used to maintain the effectiveness of SOPs through evaluation and revision. The information provided herein will be especially useful to investigators and regulatory personnel who may lack extensive experience working with arthropods under containment conditions.

Certification & validation of biosafety level-2 & biosafety level-3 laboratories in Indian settings & common issues.

PubMed

Mourya, Devendra T; Yadav, Pragya D; Khare, Ajay; Khan, Anwar H

2017-10-01

With increasing awareness regarding biorisk management worldwide, many biosafety laboratories are being setup in India. It is important for the facility users, project managers and the executing agencies to understand the process of validation and certification of such biosafety laboratories. There are some international guidelines available, but there are no national guidelines or reference standards available in India on certification and validation of biosafety laboratories. There is no accredited government/private agency available in India to undertake validation and certification of biosafety laboratories. Therefore, the reliance is mostly on indigenous experience, talent and expertise available, which is in short supply. This article elucidates the process of certification and validation of biosafety laboratories in a concise manner for the understanding of the concerned users and suggests the important parameters and criteria that should be considered and addressed during the laboratory certification and validation process.

Developing and modifying behavioral coding schemes in pediatric psychology: a practical guide.

PubMed

Chorney, Jill MacLaren; McMurtry, C Meghan; Chambers, Christine T; Bakeman, Roger

2015-01-01

To provide a concise and practical guide to the development, modification, and use of behavioral coding schemes for observational data in pediatric psychology. This article provides a review of relevant literature and experience in developing and refining behavioral coding schemes. A step-by-step guide to developing and/or modifying behavioral coding schemes is provided. Major steps include refining a research question, developing or refining the coding manual, piloting and refining the coding manual, and implementing the coding scheme. Major tasks within each step are discussed, and pediatric psychology examples are provided throughout. Behavioral coding can be a complex and time-intensive process, but the approach is invaluable in allowing researchers to address clinically relevant research questions in ways that would not otherwise be possible. © The Author 2014. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Intelligent alarming

NASA Technical Reports Server (NTRS)

Braden, W. B.

1992-01-01

This talk discusses the importance of providing a process operator with concise information about a process fault including a root cause diagnosis of the problem, a suggested best action for correcting the fault, and prioritization of the problem set. A decision tree approach is used to illustrate one type of approach for determining the root cause of a problem. Fault detection in several different types of scenarios is addressed, including pump malfunctions and pipeline leaks. The talk stresses the need for a good data rectification strategy and good process models along with a method for presenting the findings to the process operator in a focused and understandable way. A real time expert system is discussed as an effective tool to help provide operators with this type of information. The use of expert systems in the analysis of actual versus predicted results from neural networks and other types of process models is discussed.

AANA Journal Course: update for nurse anesthetists. Arrhythmia management devices and electromagnetic interference.

PubMed

Mattingly, Emily

2005-04-01

The technological complexity of implantable arrhythmia management devices, specifically pacemakers and defibrillators, has increased dramatically since their introduction only a few decades ago. Patients with such devices are encountered much more frequently in hospitals and surgery centers, yet anesthesia provider knowledge of safe and proper management is often incomplete. Anesthesia textbooks and references may provide only short paragraphs on arrhythmia management devices that do not address important perioperative management strategies for this ever-growing patient population. It is no longer satisfactory to simply place a magnet over an implanted device during surgery and assume that this action protects the patient from harm due to electromagnetic interference from inappropriate device function. This AANA Journal course serves as a concise review of basic device function, the sources and effects of electromagnetic interference in the operative setting, and patient management recommendations from current literature.

A concise review on advances in development of small molecule anti-inflammatory therapeutics emphasising AMPK: An emerging target.

PubMed

Gejjalagere Honnappa, Chethan; Mazhuvancherry Kesavan, Unnikrishnan

2016-12-01

Inflammatory diseases are complex, multi-factorial outcomes of evolutionarily conserved tissue repair processes. For decades, non-steroidal anti-inflammatory drugs and cyclooxygenase inhibitors, the primary drugs of choice for the management of inflammatory diseases, addressed individual targets in the arachidonic acid pathway. Unsatisfactory safety and efficacy profiles of the above have necessitated the development of multi-target agents to treat complex inflammatory diseases. Current anti-inflammatory therapies still fall short of clinical needs and the clinical trial results of multi-target therapeutics are anticipated. Additionally, new drug targets are emerging with improved understanding of molecular mechanisms controlling the pathophysiology of inflammation. This review presents an outline of small molecules and drug targets in anti-inflammatory therapeutics with a summary of a newly identified target AMP-activated protein kinase, which constitutes a novel therapeutic pathway in inflammatory pathology. © The Author(s) 2016.

Material Innovation in Advancing Organometal Halide Perovskite Functionality.

PubMed

Zheng, Fan; Saldana-Greco, Diomedes; Liu, Shi; Rappe, Andrew M

2015-12-03

Organometal halide perovskites (OMHPs) have garnered much attention recently for their unprecedented rate of increasing power conversion efficiency (PCE), positioning them as a promising basis for the next-generation photovoltaic devices. However, the gap between the rapid increasing PCE and the incomplete understanding of the structure-property-performance relationship prevents the realization of the true potential of OMHPs. This Perspective aims to provide a concise overview of the current status of OMHP research, highlighting the unique properties of OMHPs that are critical for solar applications but still not adequately explained. Stability and performance challenges of OMHP solar cells are discussed, calling upon combined experimental and theoretical efforts to address these challenges for pioneering commercialization of OMHP solar cells. Various material innovation strategies for improving the performance and stability of OMHPs are surveyed, showing that the OMHP architecture can serve as a promising and robust platform for the design and optimization of materials with desired functionalities.

Homepage to distribute the anatomy learning contents including Visible Korean products, comics, and books.

PubMed

Chung, Beom Sun; Chung, Min Suk

2018-03-01

The authors have operated the homepage (http://anatomy.co.kr) to provide the learning contents of anatomy. From the homepage, sectioned images, volume models, and surface models-all Visible Korean products-can be downloaded. The realistic images can be interactively manipulated, which will give rise to the interest in anatomy. The various anatomy comics (learning comics, comic strips, plastination comics, etc.) are approachable. Visitors can obtain the regional anatomy book with concise contents, mnemonics, and schematics as well as the simplified dissection manual and the pleasant anatomy essay. Medical students, health allied professional students, and even laypeople are expected to utilize the easy and comforting anatomy contents. It is hoped that other anatomists successively produce and distribute their own informative contents.

Advances in the high performance polymer electrolyte membranes for fuel cells.

PubMed

Zhang, Hongwei; Shen, Pei Kang

2012-03-21

This critical review tersely and concisely reviews the recent development of the polymer electrolyte membranes and the relationship between their properties and affecting factors like operation temperature. In the first section, the advantages and shortcomings of the corresponding polymer electrolyte membrane fuel cells are analyzed. Then, the limitations of Nafion membranes and their alternatives to large-scale commercial applications are discussed. Secondly, the concepts and approaches of the alternative proton exchange membranes for low temperature and high temperature fuel cells are described. The highlights of the current scientific achievements are given for various aspects of approaches. Thirdly, the progress of anion exchange membranes is presented. Finally, the perspectives of future trends on polymer electrolyte membranes for different applications are commented on (400 references).

ARM Climate Research Facility Quarterly Value-Added Product Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sivaraman, C.

The purpose of this report is to provide a concise status update for Value-Added Products (VAPs) implemented by the Atmospheric Radiation Measurement (ARM) Climate Research Facility. The report is divided into the following sections: (1) new VAPs for which development has begun; (2) progress on existing VAPs; (3) future VAPs that have been recently approved; (4) other work that leads to a VAP; (5) top requested VAPs from the ARM Data Archive; and (6) a summary of VAP and data releases to production and evaluation. New information is highlighted in blue text. New information about processed data by the developermore » is highlighted in red text. The upcoming milestones and dates are highlighted in green.« less

Renal-related adverse effects of intravenous contrast media in computed tomography

PubMed Central

Leow, Kheng Song; Wu, Yi Wei; Tan, Cher Heng

2015-01-01

Renal-related adverse effects of intravascular contrast media (CM) include contrast-induced nephropathy in computed tomography and angiography. While large retrospective studies have been published, the exact pathogenesis of this condition is still unknown. We review the main international guidelines, including the American College of Radiology white paper and the guidelines of European Society of Urogenital Radiology, Royal College of Radiologists and Canadian Association of Radiologists, as well as their references, regarding this subject. We present a simplified, concise approach to renal-related adverse effects of CM, taking into consideration the basis for each recommendation in these published guidelines. This will allow the reader to better understand the rationale behind appropriate patient preparation for cross-sectional imaging. PMID:25917468

Biostratigraphy and chronostratigraphy of the Cambrian-Ordovician great American carbonate bank

USGS Publications Warehouse

Taylor, John F.; Repetski, John E.; Loch, James D.; Leslie, Stephen A.

2012-01-01

The carbonate strata of the great American carbonate bank (GACB) have been subdivided and correlated with ever-increasing precision and accuracy during the past half century through use of the dominant organisms that evolved on the Laurentian platform through the Cambrian and the Ordovician. Trilobites and conodonts remain the primary groups used for this purpose, although brachiopods, both calcareous and phosphatic, and graptolites are very important in certain facies and intervals. A series of charts show the chronostratigraphic units (series and stages) currently in use for deposits of the GACB and the biostratigraphic units (zones, subzones, and biomeres) whose boundaries delineate them. Older and, in some cases obsolete, stages and faunal units are included in the figures to allow users to relate information from previous publications and/or industry databases to modern units. This chapter also provides a brief discussion on the use of biostratigraphy in the recognition and interregional correlation of supersequence boundaries within the Sauk and Tippecanoe megasequences, and the varied perspectives on the nature of biostratigraphic units and their defining taxa during the past half century. Also included are a concise update on the biomere concept, and an explanation of the biostratigraphic consequences of a profound change in the dynamics of extinction and replacement that occurred on the GACB in the Early Ordovician when the factors responsible for platformwide biomere-type extinctions faded and ultimately disappeared. A final section addresses recent and pending refinements in the genus and species taxonomy of biostratigraphically significant fossil groups, the potential they hold for greatly improved correlation, and the obstacles to be overcome for that potential to be realized.

Public Utility Commission manual for Section 210 of PURPA for Vermont

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The Public Utility Regulatory Policies Act of 1978 (PURPA) places obligations on both electric utilities and state regulatory commissions. PURPA requires every electric utility to purchase all energy and capacity made available to it, by a qualifying facility, and to sell energy and capacity to a qualifying facility upon the qualifying facility's request. State regulatory commissions must implement and administer these utility obligations and other requirements that were implemented by the Federal Energy Regulatory Commission's (FERC) final rules, which became effective March 20, 1981, and must set fair rates for electric power purchases and sales between utilities and small powermore » producers. This manual provides a concise, annotated explanation of the final FERC rules, a description of federal and state statutory authorizations, court challenges to these authorizations, analysis of the relationship between federal and state laws, analysis of Vermont's implementation of section 210 of PURPA and for comparison, annotations of selected state regulatory authority decisions.« less

Public Utility Commission manual for Section 210 of PURPA for Montana

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The Public Utility Regulatory Policies Act of 1978 (PURPA) places obligations on both electric utilities and state regulatory commissions. PURPA requires every electric utility to purchase all energy and capacity made available to it, by a qualifying facility, and to sell energy and capacity to a qualifying facility upon the qualifying facility's request. State regulatory commissions must implement and administer these utility obligations and other requirements that were implemented by the Federal Energy Regulatory Commission's (FERC) final rules, which became effective March 20, 1981; and must set fair rates for electric power purchases and sales between utilities and small powermore » producers. This manual provides a concise, annotated explanation of the final FERC rules, a description of federal and state statutory authorizations, court challenges to these authorizations analysis of the relationship between federal and state laws, analysis of Montana's implementation of section 210 of PURPA and for comparison, annotations of selected state regulatory authority decisions.« less

Public Utility Commission manual for Section 210 of PURPA for Arkansas

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The Public Utility Regulatory Policies Act of 1978 (PURPA) places obligations on both electric utilities and state regulatory commissions. PURPA requires every electric utility to purchase all energy and capacity made available to it, by a qualifying facility, and to sell energy and capacity to a qualifying facility upon the qualifying facility's request. State regulatory commissions must implement and administer these utility obligations and other requirements that were implemented by the Federal Energy Regulatory Commission's (FERC) final rules, which became effective March 20, 1981; and must set fair rates for electric power purchases and sales between utilities and small powermore » producers. This manual provides a concise, annotated explanation of the final FERC rules, a description of federal and state statutory authorizations, court challenges to these authorizations, analysis of the relationship between federal and state laws, analysis of Arkansas' implementation of section 210 of PURPA and for comparison, annotations of selected state regulatory authority decisions.« less

Development of “-omics” research in Schistosoma spp. and -omics-based new diagnostic tools for schistosomiasis

PubMed Central

Wang, Shuqi; Hu, Wei

2014-01-01

Schistosomiasis, caused by dioecious flatworms in the genus Schistosoma, is torturing people from many developing countries nowadays and frequently leads to severe morbidity and mortality of the patients. Praziquantel based chemotherapy and morbidity control for this disease adopted currently necessitate viable and efficient diagnostic technologies. Fortunately, those “-omics” researches, which rely on high-throughput experimental technologies to produce massive amounts of informative data, have substantially contributed to the exploitation and innovation of diagnostic tools of schistosomiasis. In its first section, this review provides a concise conclusion on the progresses pertaining to schistosomal “-omics” researches to date, followed by a comprehensive section on the diagnostic methods of schistosomiasis, especially those innovative ones based on the detection of antibodies, antigens, nucleic acids, and metabolites with a focus on those achievements inspired by “-omics” researches. Finally, suggestions about the design of future diagnostic tools of schistosomiasis are proposed, in order to better harness those data produced by “-omics” studies. PMID:25018752

Concise Catalog of Deep-Sky Objects

NASA Astrophysics Data System (ADS)

Finlay, Warren H.

This book is intended to give a concise summary of some of the more interesting astrophysical facts that are known about objects commonly observed by amateur astronomers. Pondering this information while viewing an object in the field has added a new level to the author's enjoyment of deep-sky observing, and it is hoped this information will be similarly enjoyed by other amateur astronomers. The book is not intended to be read cover to cover, but rather is designed so that each object entry can be read individually one at a time and in no particular order, perhaps while at the eyepiece.

Shakespeare Goes Online: Web Resources for Teaching Shakespeare.

ERIC Educational Resources Information Center

Schuetz, Carol L.

This annotated bibliography contains five sections and 62 items. The first section lists general resources including six Web site addresses; the second section, on Shakespeare's works, contains five Web site addresses; the third section, on Shakespeare and the Globe Theatre, provides five Web site addresses; the fourth section presents classroom…

Zernike expansion of derivatives and Laplacians of the Zernike circle polynomials.

PubMed

Janssen, A J E M

2014-07-01

The partial derivatives and Laplacians of the Zernike circle polynomials occur in various places in the literature on computational optics. In a number of cases, the expansion of these derivatives and Laplacians in the circle polynomials are required. For the first-order partial derivatives, analytic results are scattered in the literature. Results start as early as 1942 in Nijboer's thesis and continue until present day, with some emphasis on recursive computation schemes. A brief historic account of these results is given in the present paper. By choosing the unnormalized version of the circle polynomials, with exponential rather than trigonometric azimuthal dependence, and by a proper combination of the two partial derivatives, a concise form of the expressions emerges. This form is appropriate for the formulation and solution of a model wavefront sensing problem of reconstructing a wavefront on the level of its expansion coefficients from (measurements of the expansion coefficients of) the partial derivatives. It turns out that the least-squares estimation problem arising here decouples per azimuthal order m, and per m the generalized inverse solution assumes a concise analytic form so that singular value decompositions are avoided. The preferred version of the circle polynomials, with proper combination of the partial derivatives, also leads to a concise analytic result for the Zernike expansion of the Laplacian of the circle polynomials. From these expansions, the properties of the Laplacian as a mapping from the space of circle polynomials of maximal degree N, as required in the study of the Neumann problem associated with the transport-of-intensity equation, can be read off within a single glance. Furthermore, the inverse of the Laplacian on this space is shown to have a concise analytic form.

Specific training program improves oncologists' palliative care communication skills in a randomized controlled trial.

PubMed

Goelz, Tanja; Wuensch, Alexander; Stubenrauch, Sara; Ihorst, Gabriele; de Figueiredo, Marcelo; Bertz, Hartmut; Wirsching, Michael; Fritzsche, Kurt

2011-09-01

The aim of the study was to demonstrate that COM-ON-p, concise and individualized communication skills training (CST), improves oncologists' communication skills in consultations focusing on the transition to palliative care. Forty-one physicians were randomly assigned to a control (CG) or intervention group (IG). At t(0), all physicians held two video-recorded consultations with actor-patient pairs. Afterward, physicians in the IG participated in COM-ON-p. Five weeks after t(0), a second assessment took place (t(1)). COM-ON-p consists of an 11-hour workshop (1.5 days), pre- and postassessment (2 hours), and coaching (0.5 hours). Physicians focused on practicing individual learning goals with actor patients in small groups. To evaluate the training, blinded raters assessed communication behavior of the physicians in video-recorded actor-patient consultations using a specific checklist. Data were analyzed using a mixed model with baseline levels as covariates. Participants in the IG improved significantly more than those in the CG in all three sections of the COM-ON-Checklist: skills specific to the transition to palliative care, global communication skills, and involvement of significant others (all P < .01). Differences between the CG and IG on the global items of communication skills and involvement of significant others were also significant (P < .01). Effect sizes were medium to large, with a 0.5-point improvement on average on a five-point rating scale. Physicians can be trained to meet better core challenges during the transition to palliative care through developed concise CST. Generalization and transfer into clinical practice must be proven in additional studies.

Caesarean Section—A Density-Equalizing Mapping Study to Depict Its Global Research Architecture

PubMed Central

Brüggmann, Dörthe; Löhlein, Lena-Katharina; Louwen, Frank; Quarcoo, David; Jaque, Jenny; Klingelhöfer, Doris; Groneberg, David A.

2015-01-01

Caesarean section (CS) is a common surgical procedure. Although it has been performed in a modern context for about 100 years, there is no concise analysis of the international architecture of caesarean section research output available so far. Therefore, the present study characterizes the global pattern of the related publications by using the NewQIS (New Quality and Quantity Indices in Science) platform, which combines scientometric methods with density equalizing mapping algorithms. The Web of Science was used as a database. 12,608 publications were identified that originated from 131 countries. The leading nations concerning research activity, overall citations and country-specific h-Index were the USA and the United Kingdom. Relation of the research activity to epidemiologic data indicated that Scandinavian countries including Sweden and Finland were leading the field, whereas, in relation to economic data, countries such as Israel and Ireland led. Semi-qualitative indices such as country-specific citation rates ranked Sweden, Norway and Finland in the top positions. International caesarean section research output continues to grow annually in an era where caesarean section rates increased dramatically over the past decades. With regard to increasing employment of scientometric indicators in performance assessment, these findings should provide useful information for those tasked with the improvement of scientific achievements. PMID:26593932

A concise guide for the determination of less-studied technology-critical elements (Nb, Ta, Ga, In, Ge, Te) by inductively coupled plasma mass spectrometry in environmental samples

NASA Astrophysics Data System (ADS)

Filella, Montserrat; Rodushkin, Ilia

2018-03-01

There is an increasing demand for analytical techniques able to measure so-called 'technology-critical elements', a set of chemical elements increasingly used in technological applications, in environmental matrices. Nowadays, inductively coupled plasma-mass spectrometry (ICP-MS) has become the technique of choice for measuring trace element concentrations. However, its application is often less straightforward than often assumed. The hints and drawbacks of ICP-MS application to the measurement of a set of less-studied technology-critical elements (Nb, Ta, Ga, In, Ge and Te) is discussed here and concise guidelines given.

Vascular complications of transcatheter aortic valve replacement: A concise literature review

PubMed Central

Chaudhry, Muhammad Ali; Sardar, Muhammad Rizwan

2017-01-01

Transcatheter aortic valve replacement (TAVR) is a relatively newer therapeutic modality which offers a promising alternative to surgical aortic valve replacement for patients with prohibitive, high and intermediate surgical risk. The increasing trend to pursue TAVR in these patients has also led to growing awareness of the associated potential vascular complications. The significant impact of these complications on eventual clinical outcome and mortality makes prompt recognition and timely management a critical factor in TAVR patients. We hereby present a concise review with emphasis on diverse vascular complications associated with TAVR and their effective management to improve overall clinical outcomes. PMID:28824787

Concise Review: Process Development Considerations for Cell Therapy

PubMed Central

Brieva, Thomas; Raviv, Lior; Rowley, Jon; Niss, Knut; Brandwein, Harvey; Oh, Steve; Karnieli, Ohad

2015-01-01

The development of robust and well-characterized methods of production of cell therapies has become increasingly important as therapies advance through clinical trials toward approval. A successful cell therapy will be a consistent, safe, and effective cell product, regardless of the cell type or application. Process development strategies can be developed to gain efficiency while maintaining or improving safety and quality profiles. This review presents an introduction to the process development challenges of cell therapies and describes some of the tools available to address production issues. This article will provide a summary of what should be considered to efficiently advance a cellular therapy from the research stage through clinical trials and finally toward commercialization. The identification of the basic questions that affect process development is summarized in the target product profile, and considerations for process optimization are discussed. The goal is to identify potential manufacturing concerns early in the process so they may be addressed effectively and thus increase the probability that a therapy will be successful. Significance The present study contributes to the field of cell therapy by providing a resource for those transitioning a potential therapy from the research stage to clinical and commercial applications. It provides the necessary steps that, when followed, can result in successful therapies from both a clinical and commercial perspective. PMID:26315572

Reporting and publishing guidelines: article 12 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report.

PubMed

Wilson, Kevin C; Irwin, Richard S; File, Thomas M; Schünemann, Holger J; Guyatt, Gordon H; Rabe, Klaus F

2012-12-01

Professional societies, like many other organizations around the world, have recognized the need to use rigorous processes to ensure that health care recommendations are informed by the best available research evidence. This is the twelfth of a series of 14 articles that were prepared to advise guideline developers in respiratory and other diseases. This article discusses the reporting and publishing of guidelines. The authors formulated and discussed the following questions on the reporting and publishing of guidelines. (1) What should be reported in guidelines? (2) How should guidelines be written? (3) How should the bottom-line message be conveyed? (4) How should guidelines be packaged? (5) Where should guidelines be published? (6) Who benefits from the publication of guidelines? (7) What information should be vetted by the editor(s)? (8) How should guidelines be peer reviewed? We conducted a review of the literature, looking for systematic reviews and methodological research that addressed these questions, but we did not conduct a full systematic review. Our conclusions are based on the available evidence from the published literature and logical arguments from experienced guideline developers. There is little empirical evidence that addresses the reporting and publishing of guidelines. A standard format for reporting guidelines is desirable to ensure that guidelines are comprehensive and that all of the information necessary to judge their quality is presented. In addition, guidelines should contain concise evidence-based recommendations. To facilitate the use of guidelines by consumers, it is preferable to publish them in journals that serve the target audience and to package them in multiple ways. Editors and peer reviewers should ensure that reporting standards have been met, potential conflicts of interest have been adequately addressed and made public, and that the recommendations address important clinical questions.

Homepage to distribute the anatomy learning contents including Visible Korean products, comics, and books

PubMed Central

Chung, Beom Sun

2018-01-01

The authors have operated the homepage (http://anatomy.co.kr) to provide the learning contents of anatomy. From the homepage, sectioned images, volume models, and surface models—all Visible Korean products—can be downloaded. The realistic images can be interactively manipulated, which will give rise to the interest in anatomy. The various anatomy comics (learning comics, comic strips, plastination comics, etc.) are approachable. Visitors can obtain the regional anatomy book with concise contents, mnemonics, and schematics as well as the simplified dissection manual and the pleasant anatomy essay. Medical students, health allied professional students, and even laypeople are expected to utilize the easy and comforting anatomy contents. It is hoped that other anatomists successively produce and distribute their own informative contents. PMID:29644104

Venus: The Atmosphere, Climate, Surface, Interior and Near-Space Environment of an Earth-Like Planet

NASA Astrophysics Data System (ADS)

Taylor, Fredric W.; Svedhem, Håkan; Head, James W.

2018-02-01

This is a review of current knowledge about Earth's nearest planetary neighbour and near twin, Venus. Such knowledge has recently been extended by the European Venus Express and the Japanese Akatsuki spacecraft in orbit around the planet; these missions and their achievements are concisely described in the first part of the review, along with a summary of previous Venus observations. The scientific discussions which follow are divided into three main sections: on the surface and interior; the atmosphere and climate; and the thermosphere, exosphere and magnetosphere. These reports are intended to provide an overview for the general reader, and also an introduction to the more detailed topical surveys in the following articles in this issue, where full references to original material may be found.

Astronomical catalog desk reference, 1994 edition

NASA Technical Reports Server (NTRS)

1994-01-01

The Astronomical Catalog Desk Reference is designed to aid astronomers in locating machine readable catalogs in the Astronomical Data Center (ADC) archives. The key reference components of this document are as follows: A listing of shortened titles for all catalogs available from the ADC (includes the name of the lead author and year of publication), brief descriptions of over 300 astronomical catalogs, an index of ADC catalog numbers by subject keyword, and an index of ADC catalog numbers by author. The heart of this document is the set of brief descriptions generated by the ADC staff. The 1994 edition of the Astronomical Catalog Desk Reference contains descriptions for over one third of the catalogs in the ADC archives. Readers are encouraged to refer to this section for concise summaries of those catalogs and their contents.

Systematic review of Kinect applications in elderly care and stroke rehabilitation

PubMed Central

2014-01-01

In this paper we present a review of the most current avenues of research into Kinect-based elderly care and stroke rehabilitation systems to provide an overview of the state of the art, limitations, and issues of concern as well as suggestions for future work in this direction. The central purpose of this review was to collect all relevant study information into one place in order to support and guide current research as well as inform researchers planning to embark on similar studies or applications. The paper is structured into three main sections, each one presenting a review of the literature for a specific topic. Elderly Care section is comprised of two subsections: Fall detection and Fall risk reduction. Stroke Rehabilitation section contains studies grouped under Evaluation of Kinect’s spatial accuracy, and Kinect-based rehabilitation methods. The third section, Serious and exercise games, contains studies that are indirectly related to the first two sections and present a complete system for elderly care or stroke rehabilitation in a Kinect-based game format. Each of the three main sections conclude with a discussion of limitations of Kinect in its respective applications. The paper concludes with overall remarks regarding use of Kinect in elderly care and stroke rehabilitation applications and suggestions for future work. A concise summary with significant findings and subject demographics (when applicable) of each study included in the review is also provided in table format. PMID:24996956

Geologic setting, petrophysical characteristics, and regional heterogeneity patterns of the Smackover in southwest Alabama. Draft topical report on Subtasks 2 and 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kopaska-Merkel, D.C.; Mann, S.D.; Tew, B.H.

1992-06-01

This is the draft topical report on Subtasks 2 and 3 of DOE contract number DE-FG22-89BC14425, entitled ``Establishment of an oil and gas database for increased recovery and characterization of oil and gas carbonate reservoir heterogeneity.`` This volume constitutes the final report on Subtask 3, which had as its primary goal the geological modeling of reservoir heterogeneity in Smackover reservoirs of southwest Alabama. This goal was interpreted to include a thorough analysis of Smackover reservoirs, which was required for an understanding of Smackover reservoir heterogeneity. This report is divided into six sections (including this brief introduction). Section two, entitled ``Geologicmore » setting,`` presents a concise summary of Jurassic paleogeography, structural setting, and stratigraphy in southwest Alabama. This section also includes a brief review of sedimentologic characteristics and stratigraphic framework of the Smackover, and a summary of the diagenetic processes that strongly affected Smackover reservoirs in Alabama. Section three, entitled ``Analytical methods,`` summarizes all nonroutine aspects of the analytical procedures used in this project. The major topics are thin-section description, analysis of commercial porosity and permeability data, capillary-pressure analysis, and field characterization. ``Smackover reservoir characteristics`` are described in section four, which begins with a general summary of the petrographic characteristics of porous and permeable Smackover strata. This is followed by a more-detailed petrophysical description of Smackover reservoirs.« less

El Toro Library Solar Heating and Cooling Demonstration Project. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This report is divided into a number of essentially independent sections, each of which covers a specific topic. The sections, and the topics covered, are as follows. Section 1 provides a brief summary description of the solar energy heating and cooling system including the key final design parameters. Section 2 contains a copy of the final Acceptance Test Report. Section 3 consists of a reduced set of final updated as-built mechanical, electrical, control and instrumentations drawings of the solar energy heating and cooling system. Section 4 provides a summary of system maintenance requirements, in the form of a maintenance schedulemore » which lists necessary maintenance tasks to be performed at monthly, quarterly, semi-annual, and annual intervals. Section 5 contains a series of photographs of the final solar energy system installation, including the collector field and the mechanical equipment room. Section 6 provides a concise summary of system operation and performance for the period of December 1981 through June 1982, as measured, computed and reported by Vitro Laboratories Division of Automation Industries, Inc., for the DOE National Solar Data Network. Section 7 provides a summary of key as-built design parameters, compared with the corresponding original design concept parameters. Section 8 provides a description of a series of significant problems encountered during construction, start-up and check-out of the solar energy heating and cooling system, together with the method employed to solve the problem at the time and/or recommendations for avoiding the problem in the future design of similar systems. Appendices A through H contain the installation, operation and maintenance submittals of the various manufacturers on the major items of equipment in the system. Reference CAPE-2823.« less

Concise, stereodivergent and highly stereoselective synthesis of cis- and trans-2-substituted 3-hydroxypiperidines – development of a phosphite-driven cyclodehydration

PubMed Central

Westphal, Julia C

2014-01-01

Summary A concise (5 to 6 steps), stereodivergent, highly diastereoselective (dr up to >19:1 for both stereoisomers) and scalable synthesis (up to 14 g) of cis- and trans-2-substituted 3-piperidinols, a core motif in numerous bioactive compounds, is presented. This sequence allowed an efficient synthesis of the NK-1 inhibitor L-733,060 in 8 steps. Additionally, a cyclodehydration-realizing simple triethylphosphite as a substitute for triphenylphosphine is developed. Here the stoichiometric oxidized P(V)-byproduct (triethylphosphate) is easily removed during the work up through saponification overcoming separation difficulties usually associated to triphenylphosphine oxide. PMID:24605158

Concise Review: Pluripotent Stem Cell-Derived Cardiac Cells, A Promising Cell Source for Therapy of Heart Failure: Where Do We Stand?

PubMed

Gouadon, Elodie; Moore-Morris, Thomas; Smit, Nicoline W; Chatenoud, Lucienne; Coronel, Ruben; Harding, Sian E; Jourdon, Philippe; Lambert, Virginie; Rucker-Martin, Catherine; Pucéat, Michel

2016-01-01

Heart failure is still a major cause of hospitalization and mortality in developed countries. Many clinical trials have tested the use of multipotent stem cells as a cardiac regenerative medicine. The benefit for the patients of this therapeutic intervention has remained limited. Herein, we review the pluripotent stem cells as a cell source for cardiac regeneration. We more specifically address the various challenges of this cell therapy approach. We question the cell delivery systems, the immune tolerance of allogenic cells, the potential proarrhythmic effects, various drug mediated interventions to facilitate cell grafting and, finally, we describe the pathological conditions that may benefit from such an innovative approach. As members of a transatlantic consortium of excellence of basic science researchers and clinicians, we propose some guidelines to be applied to cell types and modes of delivery in order to translate pluripotent stem cell cardiac derivatives into safe and effective clinical trials. © 2015 AlphaMed Press.

An introduction to DARC technology.

PubMed

Ahmad, Syed Shoeb

2017-01-01

Glaucoma is a multi-factorial neurodegenerative disorder. The common denominator in all types of glaucomas is retinal ganglion cell death through apoptosis. However, this cellular demise in glaucoma is detected late by structural or functional analyses. There can be a 10-year delay prior to the appearance of visual field defects and pre-perimetric glaucoma is an issue still being addressed. However, a new cutting-edge technology called detection of apoptosing retinal cells (DARC) is being developed. This technique is capable of non-invasive, real-time visualization of apoptotic changes at the cellular level. It can detect glaucomatous cell damage at a very early stage, at the moment apoptosis starts, and thus management can be initiated even prior to development of visual field changes. In future, this technique will also be able to provide conclusive evidence of the effectiveness of treatment protocol and the need for any modifications which may be required. This article aims to provide a concise review of DARC technology.

TOPICAL REVIEW: Electronic portal imaging devices: a review and historical perspective of contemporary technologies and research

NASA Astrophysics Data System (ADS)

Antonuk, Larry E.

2002-03-01

A review of electronic portal imaging devices (EPIDs) used in external beam, megavoltage radiation therapy is presented. The review consists of a brief introduction to the definition, role and clinical significance of portal imaging, along with a discussion of radiotherapy film systems and the motivations for EPIDs. This is followed by a summary of the challenges and constraints inherent to portal imaging along with a concise, historical review of the technologies that have been explored and developed. The paper then examines, in greater depth, the two first-generation technologies that have found widespread clinical use starting from the late 1980s. This is followed by a broad overview of the physics, operation, properties and advantages of active matrix, flat-panel, megavoltage imagers, presently being commercially introduced to clinical environments or expected to be introduced in the future. Finally, a survey of contemporary research efforts focused on improving portal imaging performance by addressing various weaknesses in existing commercial systems is presented.

A revised taxonomy of assistance animals

PubMed Central

Parenti, Lindsay; Foreman, Anne; Meade, B. Jean; Wirth, Oliver

2015-01-01

The use of animals in various assistive, therapeutic, and emotional support roles has contributed to the uncoordinated expansion of labels used to distinguish these animals. To address the inconsistent vocabulary and confusion, this article proposes a concise taxonomy for classifying assistance animals. Several factors were identified to differentiate categories, including (1) whether the animal performs work or tasks related to an individual’s disability; (2) the typical level of skill required by the animal performing the work or task; (3) whether the animal is used by public service, military, or healthcare professionals; (4) whether training certifications or standards are available; and (5) the existence of legal public access protections for the animal and handler. Acknowledging that some category labels have already been widely accepted or codified, six functional categories were identified: (1) service animal; (2) public service animal; (3) therapy animal; (4) visitation animal; (5) sporting, recreational, or agricultural animal; and (6) support animal. This taxonomy provides a clear vocabulary for use by consumers, professionals working in the field, researchers, policy makers, and regulatory agencies. PMID:24203538

Enhancing presentation skills for the advanced practice nurse: strategies for success.

PubMed

Vollman, Kathleen M

2005-01-01

Professional speaking is a component of the professional practice role of the advanced practice nurse (APN). The skills to communicate effectively to one person or an audience of 100 provide the APN with the essential tools for implementing change, collaborating effectively, presenting information at professional meetings, or communicating the impact of clinical outcomes in the boardroom. Public speaking skills, a professional image, and improved communication can facilitate advancement along any career ladder. The greater your fear, the more self-confidence you will gain by stepping up to a challenge and conquering it. This article describes strategies for organizing and presenting your message in a clear and concise format. Techniques to manage the anxiety produced when attempting to articulate your thoughts is essential for effective communication. Skills for enhancing the delivery of your message through effective body language, professional image, voice modulation, and use of audiovisual aids are addressed. Creative techniques for fielding questions are key in promoting a dynamic closure and provide consistent reinforcement of the key message content.

A propagation effects handbook for satellite systems design. A summary of propagation impairments on 10-100 GHz satellite links, with techniques for system design. [tropospheric scattering

NASA Technical Reports Server (NTRS)

Kaul, R.; Wallace, R.; Kinal, G.

1980-01-01

This handbook provides satellite system engineers with a concise summary of the major propagation effects experienced on Earth-space paths in the 10 to 100 GHz frequency range. The dominant effect, attenuation due to rain, is dealt with in terms of both experimental data from measurements made in the U.S. and Canada, and the mathematical and conceptual models devised to explain the data. Rain systems, rain and attenuation models, depolarization and experimental data are described. The design techniques recommended for predicting propagation effects in Earth-space communications systems are presented. The questions of where in the system design process the effects of propagation should be considered, and what precautions should be taken when applying the propagation results are addressed in order to bridge the gap between the propagation research data and the classical link budget analysis of Earth-space communications system.

A revised taxonomy of assistance animals.

PubMed

Parenti, Lindsay; Foreman, Anne; Meade, B Jean; Wirth, Oliver

2013-01-01

The use of animals in various assistive, therapeutic, and emotional support roles has contributed to the uncoordinated expansion of labels used to distinguish these animals. To address the inconsistent vocabulary and confusion, this article proposes a concise taxonomy for classifying assistance animals. Several factors were identified to differentiate categories, including (1) whether the animal performs work or tasks related to an individual's disability; (2) the typical level of skill required by the animal performing the work or task; (3) whether the animal is used by public service, military, or healthcare professionals; (4) whether training certifications or standards are available; and (5) the existence of legal public access protections for the animal and handler. Acknowledging that some category labels have already been widely accepted or codified, six functional categories were identified: (1) service animal; (2) public service animal; (3) therapy animal; (4) visitation animal; (5) sporting, recreational, or agricultural animal; and (6) support animal. This taxonomy provides a clear vocabulary for use by consumers, professionals working in the field, researchers, policy makers, and regulatory agencies.

The Molecular Signatures Database (MSigDB) hallmark gene set collection.

PubMed

Liberzon, Arthur; Birger, Chet; Thorvaldsdóttir, Helga; Ghandi, Mahmoud; Mesirov, Jill P; Tamayo, Pablo

2015-12-23

The Molecular Signatures Database (MSigDB) is one of the most widely used and comprehensive databases of gene sets for performing gene set enrichment analysis. Since its creation, MSigDB has grown beyond its roots in metabolic disease and cancer to include >10,000 gene sets. These better represent a wider range of biological processes and diseases, but the utility of the database is reduced by increased redundancy across, and heterogeneity within, gene sets. To address this challenge, here we use a combination of automated approaches and expert curation to develop a collection of "hallmark" gene sets as part of MSigDB. Each hallmark in this collection consists of a "refined" gene set, derived from multiple "founder" sets, that conveys a specific biological state or process and displays coherent expression. The hallmarks effectively summarize most of the relevant information of the original founder sets and, by reducing both variation and redundancy, provide more refined and concise inputs for gene set enrichment analysis.

Bilingual parallel programming

DOE Office of Scientific and Technical Information (OSTI.GOV)

Foster, I.; Overbeek, R.

1990-01-01

Numerous experiments have demonstrated that computationally intensive algorithms support adequate parallelism to exploit the potential of large parallel machines. Yet successful parallel implementations of serious applications are rare. The limiting factor is clearly programming technology. None of the approaches to parallel programming that have been proposed to date -- whether parallelizing compilers, language extensions, or new concurrent languages -- seem to adequately address the central problems of portability, expressiveness, efficiency, and compatibility with existing software. In this paper, we advocate an alternative approach to parallel programming based on what we call bilingual programming. We present evidence that this approach providesmore » and effective solution to parallel programming problems. The key idea in bilingual programming is to construct the upper levels of applications in a high-level language while coding selected low-level components in low-level languages. This approach permits the advantages of a high-level notation (expressiveness, elegance, conciseness) to be obtained without the cost in performance normally associated with high-level approaches. In addition, it provides a natural framework for reusing existing code.« less

Probiotics and prebiotics--perspectives and challenges.

PubMed

Figueroa-González, Ivonne; Quijano, Guillermo; Ramírez, Gerardo; Cruz-Guerrero, Alma

2011-06-01

Owing to their health benefits, probiotics and prebiotics are nowadays widely used in yogurts and fermented milks, which are leader products of functional foods worldwide. The world market for functional foods has grown rapidly in the last three decades, with an estimated size in 2003 of ca US$ 33 billion, while the European market estimation exceeded US$ 2 billion in the same year. However, the production of probiotics and prebiotics at industrial scale faces several challenges, including the search for economical and abundant raw materials for prebiotic production, the low-cost production of probiotics and the improvement of probiotic viability after storage or during the manufacturing process of the functional food. In this review, functional foods based on probiotics and prebiotics are introduced as a key biotechnological field with tremendous potential for innovation. A concise state of the art addressing the fundamentals and challenges for the development of new probiotic- and prebiotic-based foods is presented, the niches for future research being clearly identified and discussed. Copyright © 2011 Society of Chemical Industry.

Thinking ethical and regulatory frameworks in medicine from the perspective of solidarity on both sides of the Atlantic.

PubMed

Prainsack, Barbara; Buyx, Alena

2016-12-01

This article provides a concise overview of the history of scholarship on solidarity in Europe and North America. While recent decades have seen an increase in conceptual and scholarly interest in solidarity in North America and other parts of the Anglo-Saxon world, the concept is much more strongly anchored in Europe. Continental European politics in particular have given rise to two of the most influential traditions of solidarity, namely, socialism and Christian ethics. Solidarity has also guided important public instruments and institutions in Europe (e.g., welfare, healthcare, etc.). Despite the much stronger affinity of continental European societies to solidaristic thinking, we argue that solidarity has much to offer for addressing societal challenges on both sides of the Atlantic and beyond. After proposing a working definition of solidarity that highlights its utility for guiding policy and practice, we give an example of how a solidarity-based perspective can shape instruments for the governance of data use.

Using Common Graphics Paradigms Implemented in a Java Applet to Represent Complex Scheduling Requirements

NASA Technical Reports Server (NTRS)

Jaap, John; Meyer, Patrick; Davis, Elizabeth

1997-01-01

The experiments planned for the International Space Station promise to be complex, lengthy and diverse. The scarcity of the space station resources will cause significant competition for resources between experiments. The scheduling job facing the Space Station mission planning software requires a concise and comprehensive description of the experiments' requirements (to ensure a valid schedule) and a good description of the experiments' flexibility (to effectively utilize available resources). In addition, the continuous operation of the station, the wide geographic dispersion of station users, and the budgetary pressure to reduce operations manpower make a low-cost solution mandatory. A graphical representation of the scheduling requirements for station payloads implemented via an Internet-based application promises to be an elegant solution that addresses all of these issues. The graphical representation of experiment requirements permits a station user to describe his experiment by defining "activities" and "sequences of activities". Activities define the resource requirements (with alternatives) and other quantitative constraints of tasks to be performed. Activities definitions use an "outline" graphics paradigm. Sequences define the time relationships between activities. Sequences may also define time relationships with activities of other payloads or space station systems. Sequences of activities are described by a "network" graphics paradigm. The bulk of this paper will describe the graphical approach to representing requirements and provide examples that show the ease and clarity with which complex requirements can be represented. A Java applet, to run in a web browser, is being developed to support the graphical representation of payload scheduling requirements. Implementing the entry and editing of requirements via the web solves the problems introduced by the geographic dispersion of users. Reducing manpower is accomplished by developing a concise representation which eliminates the misunderstanding possible with verbose representations and which captures the complete requirements and flexibility of the experiments.

Concise Review: Endothelial Progenitor Cells in Regenerative Medicine: Applications and Challenges

PubMed Central

Chong, Mark Seow Khoon; Ng, Wei Kai

2016-01-01

Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for revascularization strategies. Significant advances have been made in understanding the biology of EPCs, and preclinical studies have demonstrated the vasculogenic, angiogenic, and beneficial paracrine effects of transplanted EPCs in the treatment of ischemic diseases. Despite these promising results, widespread clinical acceptance of EPCs for clinical therapies remains hampered by several challenges. The present study provides a concise summary of the different EPC populations being studied for ischemic therapies and their known roles in the healing of ischemic tissues. The challenges and issues surrounding the use of EPCs and the current strategies being developed to improve the harvest efficiency and functionality of EPCs for application in regenerative medicine are discussed. Significance Endothelial progenitor cells (EPCs) have immense clinical value for cardiovascular therapies. The present study provides a concise description of the EPC subpopulations being evaluated for clinical applications. The current major lines of investigation involving preclinical and clinical evaluations of EPCs are discussed, and significant gaps limiting the translation of EPCs are highlighted. The present report could be useful for clinicians and clinical researchers with interests in ischemic therapy and for basic scientists working in the related fields of tissue engineering and regenerative medicine. PMID:26956207

Plain Language to Communicate Physical Activity Information: A Website Content Analysis.

PubMed

Paige, Samantha R; Black, David R; Mattson, Marifran; Coster, Daniel C; Stellefson, Michael

2018-04-01

Plain language techniques are health literacy universal precautions intended to enhance health care system navigation and health outcomes. Physical activity (PA) is a popular topic on the Internet, yet it is unknown if information is communicated in plain language. This study examined how plain language techniques are included in PA websites, and if the use of plain language techniques varies according to search procedures (keyword, search engine) and website host source (government, commercial, educational/organizational). Three keywords ("physical activity," "fitness," and "exercise") were independently entered into three search engines (Google, Bing, and Yahoo) to locate a nonprobability sample of websites ( N = 61). Fourteen plain language techniques were coded within each website to examine content formatting, clarity and conciseness, and multimedia use. Approximately half ( M = 6.59; SD = 1.68) of the plain language techniques were included in each website. Keyword physical activity resulted in websites with fewer clear and concise plain language techniques ( p < .05), whereas fitness resulted in websites with more clear and concise techniques ( p < .01). Plain language techniques did not vary by search engine or the website host source. Accessing PA information that is easy to understand and behaviorally oriented may remain a challenge for users. Transdisciplinary collaborations are needed to optimize plain language techniques while communicating online PA information.

Science communication in the field of fundamental biomedical research (editorial).

PubMed

Illingworth, Sam; Prokop, Andreas

2017-10-01

The aim of this special issue on science communication is to inspire and help scientists who are taking part or want to take part in science communication and engage with the wider public, clinicians, other scientists or policy makers. For this, some articles provide concise and accessible advice to individual scientists, science networks, or learned societies on how to communicate effectively; others share rationales, objectives and aims, experiences, implementation strategies and resources derived from existing long-term science communication initiatives. Although this issue is primarily addressing scientists working in the field of biomedical research, much of it similarly applies to scientists from other disciplines. Furthermore, we hope that this issue will also be used as a helpful resource by academic science communicators and social scientists, as a collection that highlights some of the major communication challenges that the biomedical sciences face, and which provides interesting case studies of initiatives that use a breadth of strategies to address these challenges. In this editorial, we first discuss why we should communicate our science and contemplate some of the different approaches, aspirations and definitions of science communication. We then address the specific challenges that researchers in the biomedical sciences are faced with when engaging with wider audiences. Finally, we explain the rationales and contents of the different articles in this issue and the various science communication initiatives and strategies discussed in each of them, whilst also providing some information on the wide range of further science communication activities in the biomedical sciences that could not all be covered here. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Translation and Validation of the Thai Version of a Modified Brief Pain Inventory: A Concise Instrument for Pain Assessment in Postoperative Cardiac Surgery.

PubMed

Keawnantawat, Pakamas; Thanasilp, Sureeporn; Preechawong, Sunida

2017-07-01

Acute pain after cardiac surgery can be assessed using validated instruments such as the modified interference subscale of the Brief Pain Inventory (mod-BPI). Despite the available knowledge, the Thai version of a mod-BPI has not yet been presented. To translate a mod-BPI into the Thai language (BPI-T) and to validate it in acute pain after cardiac surgery. This multisetting, cross-sectional study was done from 4 cardiac centers. With a convenience sampling technique, 132 cardiac surgery patients were enrolled during the first 72 postoperative hours. A BPI-T composed of 4 items on the intensity subscale and 6 items on the interference subscale was translated following Brislin's model. Convergent validity against the numeric rating scale (NRS), confirmatory factor analysis (CFA), and internal consistency reliability were examined. Of the total sample, 70% experienced moderate to severe pain (cutoff points of worst pain ≥ 4/10), and 65% had moderate to severe interference with deep breathing and coughing, 53% with general activity, and 49% with walking. The CFA confirmed the 2-factor structure of intensity and interference subscales consistent with the original version (root-mean-square error of approximation = 0.08, comparative fit index = 0.95, χ 2 = 39.00, df = 27, χ 2 /df = 1.44, P = 0.06). The physical and mental subdimensions under the interference subscale were determined (standardized factor loading = 0.70 and 0.42, respectively). The BPI-T also has good internal consistency (Cronbach's alpha coefficients 0.76 and 0.85). Pearson's correlation coefficients at 0.35 to 0.70 supported the convergent validity to the NRS. The BPI-T is a concise instrument for pain assessment in postoperative cardiac surgery. © 2016 World Institute of Pain.

A Patient-Centered Approach to Informed Consent: Results from a Survey and Randomized Trial.

PubMed

Krishnamurti, Tamar; Argo, Nichole

2016-08-01

Traditional informed consent documents tend to be too lengthy and technical to facilitate proper patient engagement. Patient-centered, short informed consent content could be equally informative, while minimizing patient burden and producing greater patient engagement. This study aimed to develop and evaluate patient-centered, patient-designed paper and video informed consent formats. Two studies were conducted. In study 1, 118 self-identifying asthma patients recruited from a national, online pool completed survey tasks from their personal computers. Participants in study 1 were randomly assigned to examine sections of a standard informed consent document for an asthma trial and to select information they deemed critical to their decision making. In study 2, a sample of 83 self-identifying asthma patients completed experimental tasks in a university laboratory. Participants in study 2 were randomly assigned to a full informed consent document; a shortened, patient-designed informed consent document created from study 1; or a video with content matched to the shortened paper form. Study 1 yielded a more readable, concise version of a standard informed consent document (5 v. 17 pages). This shortened, patient-designed form closely met normative criteria for good clinical practice. In study 2, participants who viewed either the shortened paper consent or video reported greater engagement than those viewing the standard paper consent, without lowered performance on any other decision-relevant variables (i.e., comprehension, judged risk/benefit, feelings of trust). The video consent format did not cause increased enrollment. Results suggest that providing concise informed consent content, systematically developed from patients' self-reported information needs, may be more effective at engaging and informing clinical trial participants than the traditional consent approach, without detriment to trial comprehension, risk assessment, or enrollment. © The Author(s) 2016.

29 CFR 1910.1003 - 13 Carcinogens (4-Nitrobiphenyl, etc.).

Code of Federal Regulations, 2010 CFR

2010-07-01

.... Disposal means the safe removal of the carcinogens addressed by this section from the work environment... in an environment free of the 13 carcinogens addressed by this section. The clean change room shall... external environment. Decontamination means the inactivation of a carcinogen addressed by this section or...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bechtel Nevada

The Nevada Test Site Environmental Report 2003 was prepared by Bechtel Nevada to meet the requirements and guidelines of the U.S. Department of Energy and the information needs of the public. This report is meant to be useful to members of the public, public officials, regulators, and Nevada Test Site contractors. The Executive Summary strives to present in a concise format the purpose of the document, the NTS mission and major programs, a summary of radiological releases and doses to the public resulting from site operations, a summary of non-radiological releases, and an overview of the Nevada Test Site Environmentalmore » Management System. The Executive Summary, combined with the following Compliance Summary, are written to meet all the objectives of the report and to be stand-alone sections for those who choose not to read the entire document.« less

FDA drug labeling: rich resources to facilitate precision medicine, drug safety, and regulatory science.

PubMed

Fang, Hong; Harris, Stephen C; Liu, Zhichao; Zhou, Guangxu; Zhang, Guoping; Xu, Joshua; Rosario, Lilliam; Howard, Paul C; Tong, Weida

2016-10-01

Here, we provide a concise overview of US Food and Drug Administration (FDA) drug labeling, which details drug products, drug-drug interactions, adverse drug reactions (ADRs), and more. Labeling data have been collected over several decades by the FDA and are an important resource for regulatory research and decision making. However, navigating through this data is challenging. To aid such navigation, the FDALabel database was developed, which contains a set of approximately 80000 labeling data. The full-text searching capability of FDALabel and querying based on any combination of specific sections, document types, market categories, market date, and other labeling information makes it a powerful and attractive tool for a variety of applications. Here, we illustrate the utility of FDALabel using case scenarios in pharmacogenomics biomarkers and ADR studies. Published by Elsevier Ltd.

Using Behavior Economics to Understand Alcohol Use Disorders: A Concise Review and Identification of Research Priorities

PubMed Central

Gray, Joshua C.; MacKillop, James

2016-01-01

We review recent advances in the application of behavioral economics to alcohol use disorders (AUDs). Specifically, we review individual differences in alcohol demand (i.e., the relative reinforcing value of alcohol) and delayed reward discounting (i.e., impulsive decision making) in relation to AUDs. Additionally, we review the efficacy of reinforcement-based clinical applications. What emerges from the literature is an extensive body of cross-sectional research implicating alcohol demand and delayed reward discounting with alcohol misuse. However, more research is needed to examine these domains across the lifespan in order to understand their longitudinal trajectories. Similarly, clinical research is consistently supportive of reinforcement-based clinical interventions, but the number of randomized controlled trials to date is relatively small and there has been limited examination of the putative mechanisms of behavior change. PMID:27795939

The Concise Knowledge Astronomy

NASA Astrophysics Data System (ADS)

Clerke, Agnes Mary; Fowler, Alfred; Ellard Gore, John

2011-01-01

Preface; Section I. History Agnes M. Clerke: 1. From Hipparchus to Laplace; 2. A century of progress; Section II. Geometrical Astronomy and Astronomical Instruments A. Fowler: 1. The Earth and its rotation; 2. The Earth's revolution round the Sun; 3. How the positions of the heavenly bodies are defined; 4. The Earth's orbit; 5. Mean solar time; 6. The movements of the Moon; 7. Movements of planets, satellites, and comets; 8. Eclipses and occultations; 9. How to find our situation on the Earth; 10. The exact size and shape of the earth; 11. The distances and dimensions of the heavenly bodies; 12. The masses of celestial bodies; 13. Gravitational effects of Sun and moon upon the Earth; 14. Instrumental measurement of angles and time; 15. Telescopes; 16. Instruments of precision; 17. Astrophysical instruments; Section III. The Solar System Agnes M. Clerke: 1. The solar system as a whole; 2. The Sun; 3. The Sun's surroundings; 4. The interior planets; 5. The Earth and Moon; 6. The planet Mars; 7. The asteroids; 8. The planet Jupiter; 9. The Saturnian system; 10. Uranus and Neptune; 11. Famous comets; 12. Nature and origin of comets; 13. Meteorites and shooting stars; Section IV. The Sidereal Heavens J.E. Gore: 1. The stars and constellations; 2. Double, multiple, and coloured stars; 3. The distances and motions of the stars; 4. Binary stars; 5. Variable and temporary stars; 6. Clusters and nebulae; 7. The construction of the heavens; Index.

Mission and science activity scheduling language

NASA Technical Reports Server (NTRS)

Hull, Larry G.

1993-01-01

To support the distributed and complex operational scheduling required for future National Aeronautics and Space Administration (NASA) missions, a formal, textual language, the Scheduling Applications Interface Language (SAIL), has been developed. Increased geographic dispersion of investigators is leading to distributed mission and science activity planning, scheduling, and operations. SAIL is an innovation which supports the effective and efficient communication of scheduling information among physically dispersed applications in distributed scheduling environments. SAIL offers a clear, concise, unambiguous expression of scheduling information in a readable, hardware independent format. The language concept, syntax, and semantics incorporate language features found useful during five years of research and prototyping with scheduling languages in physically distributed environments. SAIL allows concise specification of mission and science activity plans in a format which promotes repetition and reuse.

The second demographic transition: A concise overview of its development

PubMed Central

Lesthaeghe, Ron

2014-01-01

This article gives a concise overview of the theoretical development of the concept of the “second demographic transition” since it was coined in 1986, its components, and its applicability, first to European populations and subsequently also to non-European societies as well. Both the demographic and the societal contrasts between the first demographic transition (FDT) and the second demographic transition (SDT) are highlighted. Then, the major criticisms of the SDT theory are outlined, and these issues are discussed in the light of the most recent developments in Europe, the United States, the Far East, and Latin America. It turns out that three major SDT patterns have developed and that these evolutions are contingent on much older systems of kinship and family organization. PMID:25453112

Crohn's disease: management in adults, children and young people - concise guidance .

PubMed

Tun, Gloria Sz; Cripps, Sarah; Lobo, Alan J

2018-06-01

Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal tract. Individuals with CD present with acute inflammatory exacerbations as well as acute and chronic complications. Management requires specialist input from gastroenterologists, colorectal surgeons, nurse specialists and pharmacists as well as general and primary care physicians to allow appropriate selection of treatment options including surgery and rapid assessment and treatment of those with acute exacerbations. Monitoring of the individual and their medication is crucial in preventing and recognising complications including those associated with treatment. This concise guideline focuses on recommendations from National Institute for Health and Care Excellence (NICE) -Clinical -Guideline 152 (CG152) considered of key importance for implementation. © Royal College of Physicians 2018. All rights reserved.

Concise Review: Inner Ear Stem Cells—An Oxymoron, But Why?

PubMed Central

Ronaghi, Mohammad; Nasr, Marjan; Heller, Stefan

2012-01-01

Hearing loss, caused by irreversible loss of cochlear sensory hair cells, affects millions of patients worldwide. In this concise review, we examine the conundrum of inner ear stem cells, which obviously are present in the inner ear sensory epithelia of nonmammalian vertebrates, giving these ears the ability to functionally recover even from repetitive ototoxic insults. Despite the inability of the mammalian inner ear to regenerate lost hair cells, there is evidence for cells with regenerative capacity because stem cells can be isolated from vestibular sensory epithelia and from the neonatal cochlea. Challenges and recent progress toward identification of the intrinsic and extrinsic signaling pathways that could be used to re-establish stemness in the mammalian organ of Corti are discussed. PMID:22102534

Concise expression of a classical radiation spectrum

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, C.

1993-06-01

In this paper we present a concise expression of the classical electromagnetic radiation spectrum of a moving charge. It is shown to be equivalent to the often used and much more complicated form derived from the Lienard-Wiechert potentials when the observation distance [ital R] satisfies the condition [ital R][much gt][gamma][lambda]. The expression reveals a relationship between the radiation spectrum and the motion of the radiation source. It also forms the basis of an efficient computing approach, which is of practical value in numerical calculations of the spectral output of accelerated charges. The advantages of this approach for analytical and numericalmore » applications are discussed and the bending-magnet synchrotron radiation spectrum is calculated according to the approach.« less

Feasibility study of an Integrated Program for Aerospace vehicle Design (IPAD). Volume 1B: Concise review

NASA Technical Reports Server (NTRS)

Miller, R. E., Jr.; Southall, J. W.; Kawaguchi, A. S.; Redhed, D. D.

1973-01-01

Reports on the design process, support of the design process, IPAD System design catalog of IPAD technical program elements, IPAD System development and operation, and IPAD benefits and impact are concisely reviewed. The approach used to define the design is described. Major activities performed during the product development cycle are identified. The computer system requirements necessary to support the design process are given as computational requirements of the host system, technical program elements and system features. The IPAD computer system design is presented as concepts, a functional description and an organizational diagram of its major components. The cost and schedules and a three phase plan for IPAD implementation are presented. The benefits and impact of IPAD technology are discussed.

Systematic reviews addressing identified health policy priorities in Eastern Mediterranean countries: a situational analysis.

PubMed

El-Jardali, Fadi; Akl, Elie A; Karroum, Lama Bou; Kdouh, Ola; Akik, Chaza; Fadlallah, Racha; Hammoud, Rawan

2014-08-20

Systematic reviews can offer policymakers and stakeholders concise, transparent, and relevant evidence pertaining to pressing policy priorities to help inform the decision-making process. The production and the use of systematic reviews are specifically limited in the Eastern Mediterranean region. The extent to which published systematic reviews address policy priorities in the region is still unknown. This situational analysis exercise aims at assessing the extent to which published systematic reviews address policy priorities identified by policymakers and stakeholders in Eastern Mediterranean region countries. It also provides an overview about the state of systematic review production in the region and identifies knowledge gaps. We conducted a systematic search of the Health System Evidence database to identify published systematic reviews on policy-relevant priorities pertaining to the following themes: human resources for health, health financing, the role of the non-state sector, and access to medicine. Priorities were identified from two priority-setting exercises conducted in the region. We described the distribution of these systematic reviews across themes, sub-themes, authors' affiliations, and countries where included primary studies were conducted. Out of the 1,045 systematic reviews identified in Health System Evidence on selected themes, a total of 200 systematic reviews (19.1%) addressed the priorities from the Eastern Mediterranean region. The theme with the largest number of systematic reviews included was human resources for health (115) followed by health financing (33), access to medicine (27), and role of the non-state sector (25). Authors based in the region produced only three systematic reviews addressing regional priorities (1.5%). Furthermore, no systematic review focused on the Eastern Mediterranean region. Primary studies from the region had limited contribution to systematic reviews; 17 systematic reviews (8.5%) included primary studies conducted in the region. There are still gaps in the production of systematic reviews addressing policymakers' and stakeholders' priorities in the Eastern Mediterranean region. Efforts should be directed towards better aligning systematic review production with policy needs and priorities. Study findings can inform the agendas of researchers, research institutions, and international funding agencies of priority areas where systematic reviews are required.

Systematic reviews addressing identified health policy priorities in Eastern Mediterranean countries: a situational analysis

PubMed Central

2014-01-01

Background Systematic reviews can offer policymakers and stakeholders concise, transparent, and relevant evidence pertaining to pressing policy priorities to help inform the decision-making process. The production and the use of systematic reviews are specifically limited in the Eastern Mediterranean region. The extent to which published systematic reviews address policy priorities in the region is still unknown. This situational analysis exercise aims at assessing the extent to which published systematic reviews address policy priorities identified by policymakers and stakeholders in Eastern Mediterranean region countries. It also provides an overview about the state of systematic review production in the region and identifies knowledge gaps. Methods We conducted a systematic search of the Health System Evidence database to identify published systematic reviews on policy-relevant priorities pertaining to the following themes: human resources for health, health financing, the role of the non-state sector, and access to medicine. Priorities were identified from two priority-setting exercises conducted in the region. We described the distribution of these systematic reviews across themes, sub-themes, authors’ affiliations, and countries where included primary studies were conducted. Results Out of the 1,045 systematic reviews identified in Health System Evidence on selected themes, a total of 200 systematic reviews (19.1%) addressed the priorities from the Eastern Mediterranean region. The theme with the largest number of systematic reviews included was human resources for health (115) followed by health financing (33), access to medicine (27), and role of the non-state sector (25). Authors based in the region produced only three systematic reviews addressing regional priorities (1.5%). Furthermore, no systematic review focused on the Eastern Mediterranean region. Primary studies from the region had limited contribution to systematic reviews; 17 systematic reviews (8.5%) included primary studies conducted in the region. Conclusions There are still gaps in the production of systematic reviews addressing policymakers’ and stakeholders’ priorities in the Eastern Mediterranean region. Efforts should be directed towards better aligning systematic review production with policy needs and priorities. Study findings can inform the agendas of researchers, research institutions, and international funding agencies of priority areas where systematic reviews are required. PMID:25139256

Multivariate analyses applied to fetal, neonatal and pediatric MRI of neurodevelopmental disorders

PubMed Central

Levman, Jacob; Takahashi, Emi

2015-01-01

Multivariate analysis (MVA) is a class of statistical and pattern recognition methods that involve the processing of data that contains multiple measurements per sample. MVA can be used to address a wide variety of medical neuroimaging-related challenges including identifying variables associated with a measure of clinical importance (i.e. patient outcome), creating diagnostic tests, assisting in characterizing developmental disorders, understanding disease etiology, development and progression, assisting in treatment monitoring and much more. Compared to adults, imaging of developing immature brains has attracted less attention from MVA researchers. However, remarkable MVA research growth has occurred in recent years. This paper presents the results of a systematic review of the literature focusing on MVA technologies applied to neurodevelopmental disorders in fetal, neonatal and pediatric magnetic resonance imaging (MRI) of the brain. The goal of this manuscript is to provide a concise review of the state of the scientific literature on studies employing brain MRI and MVA in a pre-adult population. Neurological developmental disorders addressed in the MVA research contained in this review include autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, schizophrenia and more. While the results of this review demonstrate considerable interest from the scientific community in applications of MVA technologies in pediatric/neonatal/fetal brain MRI, the field is still young and considerable research growth remains ahead of us. PMID:26640765

Multivariate analyses applied to fetal, neonatal and pediatric MRI of neurodevelopmental disorders.

PubMed

Levman, Jacob; Takahashi, Emi

2015-01-01

Multivariate analysis (MVA) is a class of statistical and pattern recognition methods that involve the processing of data that contains multiple measurements per sample. MVA can be used to address a wide variety of medical neuroimaging-related challenges including identifying variables associated with a measure of clinical importance (i.e. patient outcome), creating diagnostic tests, assisting in characterizing developmental disorders, understanding disease etiology, development and progression, assisting in treatment monitoring and much more. Compared to adults, imaging of developing immature brains has attracted less attention from MVA researchers. However, remarkable MVA research growth has occurred in recent years. This paper presents the results of a systematic review of the literature focusing on MVA technologies applied to neurodevelopmental disorders in fetal, neonatal and pediatric magnetic resonance imaging (MRI) of the brain. The goal of this manuscript is to provide a concise review of the state of the scientific literature on studies employing brain MRI and MVA in a pre-adult population. Neurological developmental disorders addressed in the MVA research contained in this review include autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, schizophrenia and more. While the results of this review demonstrate considerable interest from the scientific community in applications of MVA technologies in pediatric/neonatal/fetal brain MRI, the field is still young and considerable research growth remains ahead of us.

Integrated Science Assessments

EPA Pesticide Factsheets

Integrated Science Assessments are reports that represent a concise evaluation and synthesis of the most policy-relevant science for reviewing the National Ambient Air Quality Standards for the six principal pollutants.

The Concise Guide to Pharmacology 2013/14: Enzymes

PubMed Central

Alexander, Stephen PH; Benson, Helen E; Faccenda, Elena; Pawson, Adam J; Sharman, Joanna L; Spedding, Michael; Peters, John A; Harmar, Anthony J

2013-01-01

The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.12444/full. Enzymes are one of the seven major pharmacological targets into which the Guide is divided, with the others being G protein-coupled receptors, ligand-gated ion channels, ion channels, nuclear hormone receptors, catalytic receptors and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. A new landscape format has easy to use tables comparing related targets. It is a condensed version of material contemporary to late 2013, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in previous Guides to Receptors and Channels. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and the Guide to Receptors and Channels, providing a permanent, citable, point-in-time record that will survive database updates. PMID:24528243

The Affective Reactivity Index: a concise irritability scale for clinical and research settings

PubMed Central

Stringaris, Argyris; Goodman, Robert; Ferdinando, Sumudu; Razdan, Varun; Muhrer, Eli; Leibenluft, Ellen; Brotman, Melissa A

2012-01-01

Background Irritable mood has recently become a matter of intense scientific interest. Here, we present data from two samples, one from the United States and the other from the United Kingdom, demonstrating the clinical and research utility of the parent- and self-report forms of the Affective Reactivity Index (ARI), a concise dimensional measure of irritability. Methods The US sample (n = 218) consisted of children and adolescents recruited at the National Institute of Mental Health meeting criteria for bipolar disorder (BD, n = 39), severe mood dysregulation (SMD, n = 67), children at family risk for BD (n = 35), or were healthy volunteers (n = 77). The UK sample (n = 88) was comprised of children from a generic mental health setting and healthy volunteers from primary and secondary schools. Results Parent- and self-report scales of the ARI showed excellent internal consistencies and formed a single factor in the two samples. In the US sample, the ARI showed a gradation with irritability significantly increasing from healthy volunteers through to SMD. Irritability was significantly higher in SMD than in BD by parent-report, but this did not reach significance by self-report. In the UK sample, parent-rated irritability was differentially related to emotional problems. Conclusions Irritability can be measured using a concise instrument both in a highly specialized US, as well as a general UK child mental health setting. PMID:22574736

The Concise Guide to Pharmacology 2013/14: G Protein-Coupled Receptors

PubMed Central

Alexander, Stephen PH; Benson, Helen E; Faccenda, Elena; Pawson, Adam J; Sharman, Joanna L; Spedding, Michael; Peters, John A; Harmar, Anthony J

2013-01-01

The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.12444/full. G protein-coupled receptors are one of the seven major pharmacological targets into which the Guide is divided, with the others being G protein-coupled receptors, ligand-gated ion channels, ion channels, catalytic receptors, nuclear hormone receptors, transporters and enzymes. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. A new landscape format has easy to use tables comparing related targets. It is a condensed version of material contemporary to late 2013, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in previous Guides to Receptors and Channels. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and the Guide to Receptors and Channels, providing a permanent, citable, point-in-time record that will survive database updates. PMID:24517644

The Concise Guide to Pharmacology 2013/14: Transporters

PubMed Central

Alexander, Stephen PH; Benson, Helen E; Faccenda, Elena; Pawson, Adam J; Sharman, Joanna L; Spedding, Michael; Peters, John A; Harmar, Anthony J

2013-01-01

The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.12444/full. Transporters are one of the seven major pharmacological targets into which the Guide is divided, with the others being G protein-coupled receptors, ligand-gated ion channels, ion channels, catalytic receptors, nuclear hormone receptors and enzymes. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. A new landscape format has easy to use tables comparing related targets. It is a condensed version of material contemporary to late 2013, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in previous Guides to Receptors and Channels. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and the Guide to Receptors and Channels, providing a permanent, citable, point-in-time record that will survive database updates. PMID:24528242

Procedures For Microbial-Ecology Laboratory

NASA Technical Reports Server (NTRS)

Huff, Timothy L.

1993-01-01

Microbial Ecology Laboratory Procedures Manual provides concise and well-defined instructions on routine technical procedures to be followed in microbiological laboratory to ensure safety, analytical control, and validity of results.

46 CFR 201.74 - Declaratory orders.

Code of Federal Regulations, 2010 CFR

2010-10-01

... PROCEDURE Formal Proceedings, Notice, Pleadings, Replies (Rule 7) § 201.74 Declaratory orders. The... the issuance thereof shall state clearly and concisely the nature of the controversy or uncertainty...

Scabies.

PubMed

Bielan, B

2001-08-01

The "Clinical Snapshot" series provides a concise examination of a clinical presentation including history, treatment, patient education, and nursing measures. Using the format here, you are invited to submit your "Clinical Snapshot" to Dermatology Nursing.

Concise review: Inner ear stem cells--an oxymoron, but why?

PubMed

Ronaghi, Mohammad; Nasr, Marjan; Heller, Stefan

2012-01-01

Hearing loss, caused by irreversible loss of cochlear sensory hair cells, affects millions of patients worldwide. In this concise review, we examine the conundrum of inner ear stem cells, which obviously are present in the inner ear sensory epithelia of nonmammalian vertebrates, giving these ears the ability to functionally recover even from repetitive ototoxic insults. Despite the inability of the mammalian inner ear to regenerate lost hair cells, there is evidence for cells with regenerative capacity because stem cells can be isolated from vestibular sensory epithelia and from the neonatal cochlea. Challenges and recent progress toward identification of the intrinsic and extrinsic signaling pathways that could be used to re-establish stemness in the mammalian organ of Corti are discussed. Copyright © 2011 AlphaMed Press.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kolda, Tamara Gibson

We propose two new multilinear operators for expressing the matrix compositions that are needed in the Tucker and PARAFAC (CANDECOMP) decompositions. The first operator, which we call the Tucker operator, is shorthand for performing an n-mode matrix multiplication for every mode of a given tensor and can be employed to concisely express the Tucker decomposition. The second operator, which we call the Kruskal operator, is shorthand for the sum of the outer-products of the columns of N matrices and allows a divorce from a matricized representation and a very concise expression of the PARAFAC decomposition. We explore the properties ofmore » the Tucker and Kruskal operators independently of the related decompositions. Additionally, we provide a review of the matrix and tensor operations that are frequently used in the context of tensor decompositions.« less

Modeling concepts for communication of geometric shape data

NASA Technical Reports Server (NTRS)

Collins, M. F.; Emnett, R. F.; Magedson, R. L.; Shu, H. H.

1984-01-01

ANSI5, an abbreviation for Section 5 of the American National Standard under Engineering Drawing and Related Documentation Practices (Committee Y14) on Digital Representation for Communication of Product Definition Data (ANSI Y14.26M-1981), allows encoding of a broad range of geometric shapes to be communicated through digital channels. A brief review of its underlying concepts is presented. The intent of ANSI5 is to devise a unified set of concise language formats for transmission of data pertaining to five types of geometric entities in Euclidean 3 space (E(3)). These are regarded as point like, curve like, surface like, solid like, and a combination of these types. For the first four types, ANSI5 makes a distinction between the geometry and topology. Geometry is a description of the spatial occupancy of the entity, and topology discusses the interconnectedness of the entity's boundary components.

The Histochemistry and Cell Biology compendium: a review of 2012.

PubMed

Taatjes, Douglas J; Roth, Jürgen

2013-06-01

The year 2012 was another exciting year for Histochemistry and Cell Biology. Innovations in immunohistochemical techniques and microscopy-based imaging have provided the means for advances in the field of cell biology. Over 130 manuscripts were published in the journal during 2012, representing methodological advancements, pathobiology of disease, and cell and tissue biology. This annual review of the manuscripts published in the previous year in Histochemistry and Cell Biology serves as an abbreviated reference for the readership to quickly peruse and discern trends in the field over the past year. The review has been broadly divided into multiple sections encompassing topics such as method advancements, subcellular components, extracellular matrix, and organ systems. We hope that the creation of this subdivision will serve to guide the reader to a specific topic of interest, while simultaneously providing a concise and easily accessible encapsulation of other topics in the broad area of Histochemistry and Cell Biology.

Development of the Brazilian brief version of the Diabetes Quality of Life Measure (DQOL-Brazil-8).

PubMed

Brasil, Fábio; Brasil, Andreia Mara Brolezzi; e Souza, Rodrigo Augusto de Paula; Pontarolo, Roberto; Correr, Cassyano Januário

2015-01-01

To provide for Brazil, through the selection of items of the Brazilian version of the Diabetes Quality of Life Measure (DQOL-Brazil), a concise instrument. This is a cross-sectional study in which the DQOL-Brazil was administered to 150 type 1 diabetic patients and 146 type 2 diabetic patients. The items of the instrument were selected according to the analysis of the principal components and Spearman's correlations with treatment satisfaction, glycated hemoglobin level, and Nottingham Health Profile. From a total of 44 items, only 8 were selected to compose the summary instrument (DQOL-Brazil-8). The DQOL-Brazil-8 presented Spearman's correlation of 0.873 with the DQOL-Brazil and a Cronbach's alpha coefficient of 0.702. The Brazilian health professionals now have a brief tool for a fast application that preserves the best features of the full DQOL-Brazil.

Theory of back-surface-field solar cells

NASA Technical Reports Server (NTRS)

Vonroos, O.

1979-01-01

Report describes simple concise theory of back-surface-field (BSF) solar cells (npp + junctions) based on Shockley's depletion-layer approximation and cites superiority of two-junction devices over conventional unijunction cells.

Guide to cement-based integrated pavement solutions.

DOT National Transportation Integrated Search

2011-08-01

This guide provides a clear, concise, and cohesive presentation of cement-bound materials options for 10 : specific engineering pavement applications: new concrete pavements, concrete overlays, pervious concrete, : precast pavements, roller-compacted...

10 CFR 2.348 - Separation of functions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... allocation of agency resources; or (iv) General regulatory, scientific, or engineering principles that are... decision that clearly and concisely sets forth the information or argument relied on to show the contrary...

10 CFR 2.348 - Separation of functions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... allocation of agency resources; or (iv) General regulatory, scientific, or engineering principles that are... decision that clearly and concisely sets forth the information or argument relied on to show the contrary...

47 CFR 61.33 - Letters of transmittal.

Code of Federal Regulations, 2010 CFR

2010-10-01

... inches (21.6 cm×27.9 cm) in size. All letters of transmittal must (1) Concisely explain the nature and... No. Secretary, Federal Communications Commission; Washington, DC 20554 Attention: Wireline...

Materials Laboratory Classes for First Year Undergraduates

ERIC Educational Resources Information Center

Fahy, F. W.

1975-01-01

Describes a combined demonstration and student experiment course to illustrate fundamental techniques, instrumentation, and concise report writing. Describes experiments including tensile tests, heat treatment, equilibrium diagram, microexamination, strain measurement, and recrystallization. (GH)

The role and application of ion beam analysis for studies of plasma-facing components in controlled fusion devices

NASA Astrophysics Data System (ADS)

Rubel, Marek; Petersson, Per; Alves, Eduardo; Brezinsek, Sebastijan; Coad, Joseph Paul; Heinola, Kalle; Mayer, Matej; Widdowson, Anna

2016-03-01

First wall materials in controlled fusion devices undergo serious modification by several physical and chemical processes arising from plasma-wall interactions. Detailed information is required for the assessment of material lifetime and accumulation of hydrogen isotopes in wall materials. The intention of this work is to give a concise overview of key issues in the characterization of plasma-facing materials and components in tokamaks, especially in JET with an ITER-Like Wall. IBA techniques play a particularly prominent role here because of their isotope selectivity in the low-Z range (1-10), high sensitivity and combination of several methods in a single run. The role of 3He-based NRA, RBS (standard and micro-size beam) and HIERDA in fuel retention and material migration studies is presented. The use of tracer techniques with rare isotopes (e.g. 15N) or marker layers on wall diagnostic components is described. Special instrumentation, development of equipment to enhance research capabilities and issues in handling of contaminated materials are addressed.

Genome editing in plants: Advancing crop transformation and overview of tools.

PubMed

Shah, Tariq; Andleeb, Tayyaba; Lateef, Sadia; Noor, Mehmood Ali

2018-05-07

Genome manipulation technology is one of emerging field which brings real revolution in genetic engineering and biotechnology. Targeted editing of genomes pave path to address a wide range of goals not only to improve quality and productivity of crops but also permit to investigate the fundamental roots of biological systems. These goals includes creation of plants with valued compositional properties and with characters that confer resistance to numerous biotic and abiotic stresses. Numerous novel genome editing systems have been introduced during the past few years; these comprise zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats/Cas9 (CRISPR/Cas9). Genome editing technique is consistent for improving average yield to achieve the growing demands of the world's existing food famine and to launch a feasible and environmentally safe agriculture scheme, to more specific, productive, cost-effective and eco-friendly. These exciting novel methods, concisely reviewed herein, have verified themselves as efficient and reliable tools for the genetic improvement of plants. Copyright © 2018 Elsevier Masson SAS. All rights reserved.

The rites of writing papers: steps to successful publishing for psychiatrists.

PubMed

Brakoulias, Vlasios; Macfarlane, Matthew D; Looi, Jeffrey C

2015-02-01

To encourage psychiatrists to publish high-quality articles in peer-reviewed journals by demystifying the publishing process. This paper will describe the publishing process and outline key factors that ensure that publishing is an achievable goal for psychiatrists. The publishing process can be long and often this is related to delays associated with obtaining reviewers and their comments. Negative reviewer comments often relate to grammatical and typographical errors, an insufficient literature review, failure to adequately discuss limitations and conclusions that are not adequately supported by the results. Authors who systematically respond to their paper's reviewer comments are usually successful in having their papers accepted. Success in publishing is usually determined by a topic that appeals to the readership of a journal, a credible methodology and a paper that is well-written. Publishing is achievable for all psychiatrists providing they can write a paper that delivers a clear and concise message, are willing to address reviewer comments and that their paper is tailored to the readership of the journal. © The Royal Australian and New Zealand College of Psychiatrists 2014.

Measuring outcome from vestibular rehabilitation, part II: refinement and validation of a new self-report measure.

PubMed

Morris, Anna E; Lutman, Mark E; Yardley, Lucy

2009-01-01

A prototype self-report measure of vestibular rehabilitation outcome is described in a previous paper. The objectives of the present work were to identify the most useful items and assess their psychometric properties. Stage 1: One hundred fifty-five participants completed a prototype 36-item Vestibular Rehabilitation Benefit Questionnaire (VRBQ). Statistical analysis demonstrated its subscale structure and identified redundant items. Stage 2: One hundred twenty-four participants completed a refined 22-item VRBQ and three established questionnaires (Dizziness Handicap Inventory, DHI; Vertigo Symptom Scale short form, VSS-sf; Medical Outcomes Study short form 36, SF-36) in a longitudinal study. Statistical analysis revealed four internally consistent subscales of the VRBQ: Dizziness, Anxiety, Motion-Provoked Dizziness, and Quality of Life. Correlations with the DHI, VSS-sf, and SF-36 support the validity of the VRBQ, and effect size estimates suggest that the VRBQ is more responsive than comparable questionnaires. Twenty participants completed the VRBQ twice in a 24-hour period, indicating excellent test-retest reliability. The VRBQ appears to be a concise and psychometrically robust questionnaire that addresses the main aspects of dizziness impact.

Gstat: a program for geostatistical modelling, prediction and simulation

NASA Astrophysics Data System (ADS)

Pebesma, Edzer J.; Wesseling, Cees G.

1998-01-01

Gstat is a computer program for variogram modelling, and geostatistical prediction and simulation. It provides a generic implementation of the multivariable linear model with trends modelled as a linear function of coordinate polynomials or of user-defined base functions, and independent or dependent, geostatistically modelled, residuals. Simulation in gstat comprises conditional or unconditional (multi-) Gaussian sequential simulation of point values or block averages, or (multi-) indicator sequential simulation. Besides many of the popular options found in other geostatistical software packages, gstat offers the unique combination of (i) an interactive user interface for modelling variograms and generalized covariances (residual variograms), that uses the device-independent plotting program gnuplot for graphical display, (ii) support for several ascii and binary data and map file formats for input and output, (iii) a concise, intuitive and flexible command language, (iv) user customization of program defaults, (v) no built-in limits, and (vi) free, portable ANSI-C source code. This paper describes the class of problems gstat can solve, and addresses aspects of efficiency and implementation, managing geostatistical projects, and relevant technical details.

The Ultimate Factor of Safety for Aircraft and Spacecraft Its History, Applications and Misconceptions

NASA Technical Reports Server (NTRS)

Zipay, John J.; Modlin, C. Thomas, Jr.; Larsen, Curtis E.

2016-01-01

The ultimate factor of safety (FOSULT) concept used in aircraft and spacecraft has evolved over many decades. Currently an FOSULT 1.5 is the FAR-mandated value for aircraft while an FOSULT of 1.4 has been used in various spacecraft. This paper was motivated by the desire to concisely explain the origins, proper interpretation and application of the ultimate factor of safety concept, since the authors have seen throughout their careers many misconceptions and incorrect applications of this concept. The history of the ultimate factor of safety concept is briefly summarized, the proper application of the factor of safety in aircraft design, structural analysis and operations is covered in detail, examples of limit load exceedance in aircraft and spacecraft are discussed, the evolution of the 1.4 FOSULT for spacecraft is described and some misconceptions regarding the ultimate factor of safety concept are addressed. It is hoped that this paper can be a summary resource for engineers to understand the origin, purpose and proper application of the ultimate factor of safety.

For your information. Management in the school setting: position statement.

PubMed

Zacharski, Susan; DeSisto, Marie; Pontius, Deborah; Sheets, Jodi; Richesin, Cynthia

2013-09-01

It is the position of the National Association of School Nurses (NASN) that the safe and effective management of allergies and anaphylaxis in schools requires a collaborative, multidisciplinary team approach. The registered professional school nurse (hereinafter referred to as the school nurse) is the leader in a comprehensive management approach that includes planning and coordination of care, educating staff, providing a safe environment, and ensuring prompt emergency response should exposure to a life-threatening allergen occur. Furthermore, NASN supports, in states where laws and regulations allow, the maintenance of stock nonpatient-specific epinephrine and physician-standing orders for school nurses to administer epinephrine in life-threatening situations in the school setting. School districts must have a clear, concise, all-inclusive policy in place to address the management of allergies in the school setting that should be reviewed annually (National School Boards Association [NSBA], 2012). This policy shall be consistent with federal and state laws, nursing practice standards, and established safe practices in accordance with evidence-based information and include development of a developmentally appropriate Individualized Healthcare Plan (IHP) and Emergency Care Plan (ECP).

Stem cell bioprinting for applications in regenerative medicine.

PubMed

Tricomi, Brad J; Dias, Andrew D; Corr, David T

2016-11-01

Many regenerative medicine applications seek to harness the biologic power of stem cells in architecturally complex scaffolds or microenvironments. Traditional tissue engineering methods cannot create such intricate structures, nor can they precisely control cellular position or spatial distribution. These limitations have spurred advances in the field of bioprinting, aimed to satisfy these structural and compositional demands. Bioprinting can be defined as the programmed deposition of cells or other biologics, often with accompanying biomaterials. In this concise review, we focus on recent advances in stem cell bioprinting, including performance, utility, and applications in regenerative medicine. More specifically, this review explores the capability of bioprinting to direct stem cell fate, engineer tissue(s), and create functional vascular networks. Furthermore, the unique challenges and concerns related to bioprinting living stem cells, such as viability and maintaining multi- or pluripotency, are discussed. The regenerative capacity of stem cells, when combined with the structural/compositional control afforded by bioprinting, provides a unique and powerful tool to address the complex demands of tissue engineering and regenerative medicine applications. © 2016 New York Academy of Sciences.

Department of Defense Data Model, Version 1, Fy 1998, Volume 1.

DTIC Science & Technology

1998-05-31

INSTALLATION-POSTAL-ADDRESS INSTALLATION-RESTORATION- ADVISORY -BOARD INSTALLATION-SURVEY INSTALLATION-USPS-POSTAL-ADDRESS INSTALLMENT- PAYMENT ...Standards 5 U SECTION 5 Entity Report 6 SECTION 6 Attribute Report 7 SECTION 7 Entity Relationship Report 8 SECTION 8 DoD Data Model Enhancements Report ...8 SECTION 9 Functional Area Using Model Report 8 Appendix A IDEFlx Modeling Conventions 8 Appendix B Acronyms ; 8 Appendix

Genetics Home Reference: Majeed syndrome

MedlinePlus

... Al-Saad KK, Ijadi-Maghsoodi R, El-Shanti HI, Ferguson PJ. A splice site mutation confirms the ... gov/books/NBK1974/ Citation on PubMed El-Shanti HI, Ferguson PJ. Chronic recurrent multifocal osteomyelitis: a concise ...

CSC Tip Sheets: Action Checklists

EPA Pesticide Factsheets

Learn how to use action checklists to motivate behavior change by providing a clear and concise list of activities that community members and organizations can use to reduce their carbon footprint and achieve other sustainability goals.

Integrated mobility measurement and notation system

NASA Technical Reports Server (NTRS)

Roebuck, J. A., Jr.

1967-01-01

System for description of movements and positions facilitates design of space suits with more mobility. This measurement and notation system gives concise and unequivocal descriptions, compatible with engineering analysis and applicable to specific needs.

28 CFR 0.181 - Requirements for orders.

Code of Federal Regulations, 2010 CFR

2010-07-01

... the Attorney General § 0.181 Requirements for orders. Each order prepared for issuance by or approval of the Attorney General shall be given a suitable title, shall contain a clear and concise statement...

10 CFR 2.348 - Separation of functions.

Code of Federal Regulations, 2013 CFR

2013-01-01

..., scientific, or engineering principles that are useful for an understanding of the issues in a proceeding and... final decision that clearly and concisely sets forth the information or argument relied on to show the...

10 CFR 2.348 - Separation of functions.

Code of Federal Regulations, 2014 CFR

2014-01-01

..., scientific, or engineering principles that are useful for an understanding of the issues in a proceeding and... final decision that clearly and concisely sets forth the information or argument relied on to show the...

Polarons in acetanilide

NASA Astrophysics Data System (ADS)

Scott, Alwyn C.; Bigio, Irving J.; Johnston, Clifford T.

1989-06-01

The best available data are presented of the integrated intensity of the 1650-cm-1 band in crystalline acetanilide as a function of temperature. A concise theory of polaron states is presented and used to interpret the data.

Polarons in acetanilide

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scott, A. C.; Bigio, I. J.; Johnston, C. T.

1989-06-15

The best available data are presented of the integrated intensity of the1650-cm/sup /minus/1/ band in crystalline acetanilide as a function oftemperature. A concise theory of polaron states is presented and used tointerpret the data.

Biogenetically inspired approach to the Strychnos alkaloids. Concise syntheses of (+/-)-akuammicine and (+/-)-strychnine.

PubMed

Ito, M; Clark, C W; Mortimore, M; Goh, J B; Martin, S F

2001-08-22

A linear synthesis of the indole alkaloid (+/-)-akuammicine (2) was completed by a novel sequence of reactions requiring only 10 steps from commercially available starting materials. The approach features a tandem vinylogous Mannich addition and an intramolecular hetero Diels-Alder reaction to rapidly assemble the pentacyclic heteroyohimboid derivative 8 from the readily available hydrocarboline 6. Oxidation of the E ring of 8 gave the lactone 9 that was converted into deformylgeissoschizine (11). The subsequent elaboration of 11 into 2 was effected by a biomimetically patterned transformation that involved sequential oxidation and base-induced skeletal reorganization. A variation of these tactics was then applied to the synthesis of the C(18) hydroxylated akuammicine derivative 36. Because 36 had previously been converted into strychnine (1) in four steps, its preparation constitutes a concise, formal synthesis of this complex alkaloid.

Granulocyte colony-stimulating factor in the treatment of acute radiation syndrome: a concise review.

PubMed

Hofer, Michal; Pospíšil, Milan; Komůrková, Denisa; Hoferová, Zuzana

2014-04-16

This article concisely summarizes data on the action of one of the principal and best known growth factors, the granulocyte colony-stimulating factor (G-CSF), in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. Highlighted are the topics of its real or anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with other drugs, the ability of other agents to stimulate endogenous G-CSF production, as well as of the capability of this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. G-CSF is one of the pivotal drugs in the treatment of radiation accident victims and its employment in this indication can be expected to remain or even grow in the future.

Generating Concise Rules for Human Motion Retrieval

NASA Astrophysics Data System (ADS)

Mukai, Tomohiko; Wakisaka, Ken-Ichi; Kuriyama, Shigeru

This paper proposes a method for retrieving human motion data with concise retrieval rules based on the spatio-temporal features of motion appearance. Our method first converts motion clip into a form of clausal language that represents geometrical relations between body parts and their temporal relationship. A retrieval rule is then learned from the set of manually classified examples using inductive logic programming (ILP). ILP automatically discovers the essential rule in the same clausal form with a user-defined hypothesis-testing procedure. All motions are indexed using this clausal language, and the desired clips are retrieved by subsequence matching using the rule. Such rule-based retrieval offers reasonable performance and the rule can be intuitively edited in the same language form. Consequently, our method enables efficient and flexible search from a large dataset with simple query language.

Concise Stereocontrolled Formal Synthesis of (±)-Quinine and Total Synthesis of (±)-7-Hydroxyquinine via Merged Morita-Baylis-Hillman-Tsuji-Trost Cyclization

PubMed Central

Webber, Peter; Krische, Michael J.

2010-01-01

Concise stereoselective syntheses of (±)-quinine and (±)-7-hydroxyquinine are achieved using a catalytic enone cycloallylation that combines the nucleophilic features of the Morita-Baylis-Hillman reaction and the electrophilic features of the Tsuji-Trost reaction. Cyclization of enone-allyl carbonate 11 delivers the product of cycloallylation 13 in 68% yield. Diastereoselective conjugate reduction of the enone 13 (>20:1 dr) followed by exchange of N-protecting groups provides the saturated N-Boc-protected methyl ketone 19, which upon aldol dehydration provides quinoline containing enone 15, possessing all carbon atoms of quinine. Exposure of ketone 15 to L-selectride enables diastereoselective carbonyl reduction (>20:1 dr) to furnish the allylic alcohol 16. Stereoselective hydroxyl-directed epoxidation using an oxovanadium catalyst modified by N-hydroxy-N-Me-pivalamide delivers epoxide 17 (17:1 dr). Cyclization of the resulting amine-epoxide 17 provides (±)-7-hydroxyquinine in 13 steps and 11% overall yield from aminoacetaldehyde diethyl acetal. Notably, highly stereoselective formation of five contiguous stereocenters is achieved through a series of 1,2-asymmetric induction events. A formal synthesis of (±)-quinine is achieved upon deoxygenation of the N-Cbz-protected allylic acetate 22 to provide olefin 23, which previously has been converted to quinine. Thus, (±)-quinine is accessible in 16 steps and 4% overall yield from commercial aminoacetaldehyde diethyl acetal, making this route the most concise approach to quinine, to date. PMID:18989927

Relationship between the quality of children's handwriting and the Beery Buktenica developmental test of visuomotor integration after one year of writing tuition.

PubMed

Duiser, Ivonne H F; van der Kamp, John; Ledebt, Annick; Savelsbergh, Geert J P

2014-04-01

We examined whether the three subtests of the Beery Buktenica developmental test of visuomotor integration predicted quality of handwriting across and within groups of boys and girls classified as proficient, at risk or non-proficient writers according to the Concise Assessment Scale for Children's Handwriting. The Beery Buktenica developmental test of visuomotor integration and the Concise Assessment Scale for Children's Handwriting tests were administered to 240 grade 2 children. Proficient writers scored better on the visuomotor integration subtest than non-proficient writers, while proficient and at risk writers scored better than non-proficient writers on the motor coordination subtest. No differences were found on the visual perception subtest. Girls were more often classified as proficient writers than boys, and they scored better on the motor coordination subtest. Across groups, regression indicated that gender and both the visuomotor integration subtest and the motor coordination subtest were significant predictors for the quality of handwriting (i.e., accounted for 17% of the variance). After one year of writing tuition, the visuomotor integration subtest (and to a lesser extent the motor coordination subtest) but not the visual perception subtest significant relates to quality of children's handwriting as measured with the Concise Assessment Scale for Children's Handwriting. However, the relatively little variance explained also points to other abilities and/or task constraints that underlie quality of handwriting. © 2013 Occupational Therapy Australia.

Integrated Science Assessment (ISA) for Carbon Monoxide ...

EPA Pesticide Factsheets

EPA announced that the Second External Review Draft of the Integrated Science Assessment (ISA) for Carbon Monoxide (CO) and related Annexes was made available for independent peer review and public review. This draft ISA document represents a concise synthesis and evaluation of the most policy-relevant science and will ultimately provide the scientific bases for EPA's decision regarding whether the current standards for CO sufficiently protect public health and the environment. Section 108(a) of the Clean Air Act directs the EPA Administrator to identify certain pollutants that “cause or contribute to air pollution which may reasonably be anticipated to endanger public health or welfare” and to issue air quality criteria for them. These air quality criteria are to “accurately reflect the latest scientific knowledge useful in indicating the kind and extent of all identifiable effects on public health or welfare which may be expected from the presence of such pollutant in the ambient air….” Under section 109 of the Act, EPA is to establish national ambient air quality standards (NAAQS) for each pollutant for which EPA has issued criteria. Section 109(d) of the Act requires periodic review and, if appropriate, revision of existing air quality criteria to reflect advances in scientific knowledge on the effects of the pollutant on public health or welfare. EPA is also to revise the NAAQS, if appropriate, based on the revised air quality criteria.

Wood machining highlights, 1972 and 1973

Treesearch

Charles W. Mcmillin

1975-01-01

Important wood machining research published during 1972 and 1973 is highlighted to provide the reader with a concise summary of activity in 17 fields of endeavor. The review is based on 427 references and contains 154 citations.

Geometric Design Laboratory Fact Sheet

DOT National Transportation Integrated Search

2006-08-02

This fact sheet provides concise information about the Geometric Design Laboratory (GDL) at the Turner-Fairbank Highway Research Center. The mission of the GDL is to provide technical support to the Federal Highway Administration's Office of Safety R...

WHAT'S the Matter at Rhic?

NASA Astrophysics Data System (ADS)

de Cassagnac, Raphael Granier

I present here a concise review of the experimental results obtained at the Relativistic Heavy Ion Collider (RHIC), which shed light on the hot and dense quark gluon matter produced at these high temperature and density conditions.

Magnetohydrodynamic power generation

NASA Technical Reports Server (NTRS)

Smith, J. L.

1984-01-01

Magnetohydrodynamic (MHD) Power Generation is a concise summary of MHD theory, history, and future trends. Results of the major international MHD research projects are discussed. Data from MHD research is included. Economics of initial and operating costs are considered.

Solid state Impatt Amplifiers performance data

DOT National Transportation Integrated Search

1973-12-01

Evaluation data on an 8-watt and a 16-watt Impatt Amplifier represented to concisely describe the performance of these amplifiers. The data include component specifications and photographs, TSC test set-up configuration, amplitude and phase character...

Sustainable concrete pavements : a manual of practice.

DOT National Transportation Integrated Search

2011-08-01

Developed as a more detailed follow-up to a 2009 briefing document, Building Sustainable Pavement with Concrete, this guide provides a clear, concise, and cohesive discussion of pavement sustainability concepts and of recommended practices for maximi...

Guide for Commenting on NEEDS and IPM

EPA Pesticide Factsheets

Find on this page a document intended to provide guidance on submitting clear, concise, and impactful comments on NEEDS (National Electric Energy Data System), other inputs to the Integrated Planning Model (IPM), or outputs from IPM.

Wood Machining Highlights, 1972 and 1973

Treesearch

C.W. McMillin

1975-01-01

Important wood machining research published during 1972 and 1973 is highlighted to provide the reader with a concise summary of activity in 17 fields of endeavor. The review is based on 427 references and contains 154 citations.

Benzo[b]fluorenes via indanone dianion annulation: a short synthesis of prekinamycin.

PubMed

Birman, Vladimir B; Zhao, Zhufeng; Guo, Lei

2007-03-29

[structure: see text]. A rapid construction of benzo[b]fluorenones via reaction of 1-indanone dianions with phthalate diesters is described. Its utility is illustrated with a concise synthesis of prekinamycin.

Defining Terrorism.

ERIC Educational Resources Information Center

Hoffman, Bruce

1986-01-01

Notes the lack of a concise meaning for the word terrorism. Develops a working definition which states that terrorism is the deliberate creation and exploitation of fear through violence or the threat of violence in the attainment of political objectives. (JDH)

8 CFR 265.1 - Forms.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Forms. 265.1 Section 265.1 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS NOTICES OF ADDRESS § 265.1 Forms. Except... under section 262 of the Act shall report each change of address and new address within 10 days on Form...

Manyscale Computing for Sensor Processing in Support of Space Situational Awareness

NASA Astrophysics Data System (ADS)

Schmalz, M.; Chapman, W.; Hayden, E.; Sahni, S.; Ranka, S.

2014-09-01

Increasing image and signal data burden associated with sensor data processing in support of space situational awareness implies continuing computational throughput growth beyond the petascale regime. In addition to growing applications data burden and diversity, the breadth, diversity and scalability of high performance computing architectures and their various organizations challenge the development of a single, unifying, practicable model of parallel computation. Therefore, models for scalable parallel processing have exploited architectural and structural idiosyncrasies, yielding potential misapplications when legacy programs are ported among such architectures. In response to this challenge, we have developed a concise, efficient computational paradigm and software called Manyscale Computing to facilitate efficient mapping of annotated application codes to heterogeneous parallel architectures. Our theory, algorithms, software, and experimental results support partitioning and scheduling of application codes for envisioned parallel architectures, in terms of work atoms that are mapped (for example) to threads or thread blocks on computational hardware. Because of the rigor, completeness, conciseness, and layered design of our manyscale approach, application-to-architecture mapping is feasible and scalable for architectures at petascales, exascales, and above. Further, our methodology is simple, relying primarily on a small set of primitive mapping operations and support routines that are readily implemented on modern parallel processors such as graphics processing units (GPUs) and hybrid multi-processors (HMPs). In this paper, we overview the opportunities and challenges of manyscale computing for image and signal processing in support of space situational awareness applications. We discuss applications in terms of a layered hardware architecture (laboratory > supercomputer > rack > processor > component hierarchy). Demonstration applications include performance analysis and results in terms of execution time as well as storage, power, and energy consumption for bus-connected and/or networked architectures. The feasibility of the manyscale paradigm is demonstrated by addressing four principal challenges: (1) architectural/structural diversity, parallelism, and locality, (2) masking of I/O and memory latencies, (3) scalability of design as well as implementation, and (4) efficient representation/expression of parallel applications. Examples will demonstrate how manyscale computing helps solve these challenges efficiently on real-world computing systems.

20 CFR 30.720 - How can an excluded provider request a hearing?

Code of Federal Regulations, 2010 CFR

2010-04-01

... shall contain: (a) A concise notice of the issues on which the provider desires to give evidence at the... medical standards, medical ethics or medical regulation for an advisory opinion from a competent...

20 CFR 10.820 - How can an excluded provider request a hearing?

Code of Federal Regulations, 2010 CFR

2010-04-01

... named under § 10.818(f) and shall contain: (a) A concise notice of the issues on which the provider... questions concerning professional medical standards, medical ethics or medical regulation for an advisory...

Strategies for improving traveler information.

DOT National Transportation Integrated Search

2011-01-01

This project developed a clear, concise, and fiscally sound plan to improve traveler information : for the Michigan Department of Transportation (DOT). The DOT has a long history of innovation : in the field of ITS, including a robust traveler inform...

FRATIS concept of operations : assess test readiness of FRATIS (task 4).

DOT National Transportation Integrated Search

2012-08-01

This technical memorandum presents a concise assessment of the key technical and nontechnical issues and limitations related to field-testing the Freight Advanced Traveler Information System (FRATIS) Dynamic Mobility Applications (DMA) bundle and its...

75 FR 57261 - Request for Comments on Incentivizing Humanitarian Technologies and Licensing Through the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-20

... to develop a workable test to apply these principles that is clear, concise, administratively... was made available to researchers on generous terms. The USPTO seeks to develop a workable test to...

Cybernetics and Workshop Design.

ERIC Educational Resources Information Center

Eckstein, Daniel G.

1979-01-01

Cybernetic sessions allow for the investigation of several variables concurrently, resulting in a large volume of input compacted into a concise time frame. Three session questions are reproduced to illustrate the variety of ideas generated relative to workshop design. (Author)

Concise, Enantioselective Total Synthesis of (-)-Alstonerine

PubMed Central

Miller, Kenneth A.

2008-01-01

A novel enantioselective total synthesis of (-)-alstonerine has been completed that requires only 1 5 steps from L-tryptophan. The synthesis features the first application of a Pauson-Khand reaction t o synthesize an azabridged bicyclic skeleton. PMID:17298078

Quantitative evaluation of refolding conditions for a disulfide-bond-containing protein using a concise 18O-labeling technique

PubMed Central

Uchimura, Hiromasa; Kim, Yusam; Mizuguchi, Takaaki; Kiso, Yoshiaki; Saito, Kazuki

2011-01-01

A concise method was developed for quantifying native disulfide-bond formation in proteins using isotopically labeled internal standards, which were easily prepared with proteolytic 18O-labeling. As the method has much higher throughput to estimate the amounts of fragments possessing native disulfide arrangements by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) than the conventional high performance liquid chromatography (HPLC) analyses, it allows many different experimental conditions to be assessed in a short time. The method was applied to refolding experiments of a recombinant neuregulin 1-β1 EGF-like motif (NRG1-β1), and the optimum conditions for preparing native NRG1-β1 were obtained by quantitative comparisons. Protein disulfide isomerase (PDI) was most effective at the reduced/oxidized glutathione ratio of 2:1 for refolding the denatured sample NRG1-β1 with the native disulfide bonds. PMID:21500299

Soft Systems Methodology

NASA Astrophysics Data System (ADS)

Checkland, Peter; Poulter, John

Soft systems methodology (SSM) is an approach for tackling problematical, messy situations of all kinds. It is an action-oriented process of inquiry into problematic situations in which users learn their way from finding out about the situation, to taking action to improve it. The learning emerges via an organised process in which the situation is explored using a set of models of purposeful action (each built to encapsulate a single worldview) as intellectual devices, or tools, to inform and structure discussion about a situation and how it might be improved. This paper, written by the original developer Peter Checkland and practitioner John Poulter, gives a clear and concise account of the approach that covers SSM's specific techniques, the learning cycle process of the methodology and the craft skills which practitioners develop. This concise but theoretically robust account nevertheless includes the fundamental concepts, techniques, core tenets described through a wide range of settings.

Design and Fabrication of Full Wheatstone-Bridge-Based Angular GMR Sensors.

PubMed

Yan, Shaohua; Cao, Zhiqiang; Guo, Zongxia; Zheng, Zhenyi; Cao, Anni; Qi, Yue; Leng, Qunwen; Zhao, Weisheng

2018-06-05

Since the discovery of the giant magnetoresistive (GMR) effect, GMR sensors have gained much attention in last decades due to their high sensitivity, small size, and low cost. The full Wheatstone-bridge-based GMR sensor is most useful in terms of the application point of view. However, its manufacturing process is usually complex. In this paper, we present an efficient and concise approach to fabricate a full Wheatstone-bridge-based angular GMR sensor by depositing one GMR film stack, utilizing simple patterned processes, and a concise post-annealing procedure based on a special layout. The angular GMR sensor is of good linear performance and achieves a sensitivity of 0.112 mV/V/Oe at the annealing temperature of 260 °C in the magnetic field range from -50 to +50 Oe. This work provides a design and method for GMR-sensor manufacturing that is easy for implementation and suitable for mass production.

Concise Review: Dental Pulp Stem Cells: A Novel Cell Therapy for Retinal and Central Nervous System Repair.

PubMed

Mead, Ben; Logan, Ann; Berry, Martin; Leadbeater, Wendy; Scheven, Ben A

2017-01-01

Dental pulp stem cells (DPSC) are neural crest-derived ecto-mesenchymal stem cells that can relatively easily and non-invasively be isolated from the dental pulp of extracted postnatal and adult teeth. Accumulating evidence suggests that DPSC have great promise as a cellular therapy for central nervous system (CNS) and retinal injury and disease. The mode of action by which DPSC confer therapeutic benefit may comprise multiple pathways, in particular, paracrine-mediated processes which involve a wide array of secreted trophic factors and is increasingly regarded as the principal predominant mechanism. In this concise review, we present the current evidence for the use of DPSC to repair CNS damage, including recent findings on retinal ganglion cell neuroprotection and regeneration in optic nerve injury and glaucoma. Stem Cells 2017;35:61-67. © 2016 AlphaMed Press.

Targeted nanosystems: Advances in targeted dendrimers for cancer therapy.

PubMed

Yang, Hu

2016-02-01

Dendrimers possess discrete highly compact nanostructures constituted of successive branched layers. Soon after the inception of dendrimers, recognition of their tunable structures and biologically favorable properties provoked a great enthusiasm in delving deeply into the utility of dendrimers for biomedical and pharmaceutical applications. One of the most important nanotechnology applications is the development of nanomedicines for targeted cancer therapies. Tremendous success in targeted therapies has been achieved with the use of dendrimer-based nanomedicines. This article provides a concise review on latest advances in the utility of dendrimers in immunotherapies and hormone therapies. Much basic and clinical research has been done since the invention of dendrimers, which are highly branched nano-sized molecules with the ability to act as carriers in nanomedicine. In this concise review article, the authors highlighted the current use of dendrimers in immunotherapies and hormone therapies in the fight against cancers. Copyright © 2015 Elsevier Inc. All rights reserved.

Mechanical modeling for magnetorheological elastomer isolators based on constitutive equations and electromagnetic analysis

NASA Astrophysics Data System (ADS)

Wang, Qi; Dong, Xufeng; Li, Luyu; Ou, Jinping

2018-06-01

As constitutive models are too complicated and existing mechanical models lack universality, these models are beyond satisfaction for magnetorheological elastomer (MRE) devices. In this article, a novel universal method is proposed to build concise mechanical models. Constitutive model and electromagnetic analysis were applied in this method to ensure universality, while a series of derivations and simplifications were carried out to obtain a concise formulation. To illustrate the proposed modeling method, a conical MRE isolator was introduced. Its basic mechanical equations were built based on equilibrium, deformation compatibility, constitutive equations and electromagnetic analysis. An iteration model and a highly efficient differential equation editor based model were then derived to solve the basic mechanical equations. The final simplified mechanical equations were obtained by re-fitting the simulations with a novel optimal algorithm. In the end, verification test of the isolator has proved the accuracy of the derived mechanical model and the modeling method.

Assessment and management of alcohol dependence and withdrawal in the acute hospital: concise guidance.

PubMed

Stewart, Stephen; Swain, Sharon

2012-06-01

Alcohol dependence is common among patients attending acute hospitals. It can be the major reason for attendance or a significant cofactor. Assessment of these patients in the acute setting can be challenging owing to the multidisciplinary approach required. Doctors in acute hospitals are often inexperienced in managing dependence, a mental health problem. They might focus on the physical harms or the withdrawal, a consequence of the dependence. For this reason, assessment of dependence and prevention and management of acute alcohol withdrawal are often suboptimal. There is little existing guidance on how to manage this patient population, especially in non-specialist settings. With recently published National Institute for Health and Clinical Excellence (NICE) guidance on the management of dependence and withdrawal, now is the perfect time to produce concise guidelines in the hope that a more succinct suite of guidance can reach a larger audience.

16 CFR 681.2 - Duties of card issuers regarding changes of address.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Duties of card issuers regarding changes of address. 681.2 Section 681.2 Commercial Practices FEDERAL TRADE COMMISSION THE FAIR CREDIT REPORTING ACT IDENTITY THEFT RULES § 681.2 Duties of card issuers regarding changes of address. (a) Scope. This section...

28 CFR 51.25 - Withdrawal of submissions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... SECTION 5 OF THE VOTING RIGHTS ACT OF 1965, AS AMENDED Procedures for Submission to the Attorney General... addressed to the Chief, Voting Section, Civil Rights Division, to be delivered at the addresses...

28 CFR 51.24 - Address for submissions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... SECTION 5 OF THE VOTING RIGHTS ACT OF 1965, AS AMENDED Procedures for Submission to the Attorney General... submission shall be clearly marked: Submission under section 5 of the Voting Rights Act. [Order 1214-87, 52... General via the U.S. Postal Service shall be addressed to the Chief, Voting Section, Civil Rights Division...

Detailed Facility Report Data Dictionary | ECHO | US EPA

EPA Pesticide Factsheets

The Detailed Facility Report Data Dictionary provides users with a list of the variables and definitions that have been incorporated into the Detailed Facility Report. The Detailed Facility Report provides a concise enforcement and compliance history for a facility.

Is Science Logical?

ERIC Educational Resources Information Center

Pease, Craig M.; Bull, J. J.

1992-01-01

Offers a concise, abstract description of the scientific method different from the historical, philosophical, and case-study approaches, which lead to comprehension of this method. Discusses features of scientific models, dynamic interactions underlying scientific progress, ways that scientist successfully understand nature, mechanisms for…

Religion and Multiculturalism in Education.

ERIC Educational Resources Information Center

Alexander, H. A.

1995-01-01

Provides a concise historical overview of theological thinking concerning fundamentalism, absolutism, and relativism. Considers corresponding responses to issues regarding multiculturalism. Concludes that a diversity of viewpoints is necessary for society to learn from its mistakes and progress in a positive fashion. (MJP)

The Good Buy.

ERIC Educational Resources Information Center

Newsom, John

2002-01-01

Describes school purchasing process, examples of illegal or wasteful purchasing activities, a concise ethical guide to school purchasing excerpted from the Texas Agency's Financial Accountability System Resource Guide, and suggestions from experts on how schools can ensure legal and ethical purchasing practices. (PKP)

Correcting a Widespread Error concerning the Angular Velocity of a Rotating Rigid Body.

ERIC Educational Resources Information Center

Leubner, C.

1981-01-01

Since many texts use an incorrect argument in obtaining the instantaneous velocity of a rotating body, a correct and concise derivation of this quantity for a rather general case is given. (Author/SK)

Research Update: Write Research to be Read.

ERIC Educational Resources Information Center

Murray, Donald M.

1982-01-01

Discusses 10 rules of thumb for writing educational research reports that are concise and accessible. The principles include writing in terms of people, emphasizing the positive, editing for simplicity, and breaking any of the previously discussed rules when necessary. (HTH)

Public reporting, consumerism, and patient empowerment.

PubMed

Huckman, Robert S; Kelley, Mark A

2013-11-14

Public reporting of health care outcomes is largely ignored by consumers, perhaps because it doesn't include concise, comprehensible information on factors such as out-of-pocket costs, the effectiveness of a procedure or treatment, and applicability to their situation.

Synthesis of labeled meropenem for the analysis of M. tuberculosis transpeptidases.

PubMed

Kastrinsky, David B; Barry, Clifton E

2010-01-01

A concise synthesis of (14)C labeled meropenem prepared from (14)C dimethylamine hydrochloride is described. Using a similar reaction sequence, the meropenem nucleus was also attached to biotin providing a probe for protein interaction studies.

ITS logical architecture : volume II, process specifications.

DOT National Transportation Integrated Search

1981-07-01

Author's abstract: This report identifies 24 critical issues related to pedestrian and bicycle facilities and programs, summarizes the state-of-the-art on each issue as it is contained in the published literature, and provides a concise commentary on...

Seborrheic dermatitis: a clinical practice snapshot.

PubMed

Schmidt, Jennifer A

2011-08-01

Seborrheic dermatitis is a chronic, recurring skin disorder that has no cure.Current clinical research has implicated Malassezia yeast in the etiology. Using a clear, concise clinical picture and a thorough patient history, even the novice NP can formulate an effective treatment plan.

Successfully Preparing Your CMS Web Area for OWC Review

EPA Pesticide Factsheets

Common issues in draft websites reviewed by EPA's Office of Web Communications that result in multiple rounds of review; such as lack of focus on key audiences' top tasks, not using plain language and conciseness, and unclear titles and headings.

From Chains for Mean Value Inequalities to Mitrinovic's Problem II

ERIC Educational Resources Information Center

Zhu, Ling

2005-01-01

In this note, an integrated form of some significant means with two variables is provided, and some chains for mean value inequalities are obtained. At the same time, a concise family of algebraic functions appears, which satisfy Mitrinovic's requirements.

10 CFR 603.1005 - General responsibilities.

Code of Federal Regulations, 2010 CFR

2010-01-01

... incorporate clauses from the Federal Acquisition Regulation (48 CFR parts 1-53) or Department of Energy Acquisition Regulation (48 CFR parts 901-970) because those provisions are designed for procurement contracts...) Be written in clear and concise language, to minimize potential ambiguity. ...

Aging integumentary system. Podiatric review.

PubMed

Muehlman, C; Rahimi, F

1990-11-01

The authors present a concise review of age-related changes that occur in the skin and its derivatives, as they pertain to the podiatric practitioner. A brief discussion of wound healing and several common skin disorders that affect the elderly is also included.

Humans and the Environment in America's Past.

ERIC Educational Resources Information Center

Harvey, Mark W. T.

1996-01-01

Presents a concise and interesting overview of U.S. attitudes towards nature, conservation, and environmental issues. Traces the constantly shifting relationship between these issues and social and commercial interests. Follows this relationship from the early colonists to the current environmental movement. (MJP)

Immune System Toxicity and Immunotoxicity Hazard Identification

EPA Science Inventory

Exposure to chemicals may alter immune system health, increasing the risk of infections, allergy and autoimmune diseases. The chapter provides a concise overview of the immune system, host factors that affect immune system heal, and the effects that xenobiotic exposure may have ...

Best Practices for Effective Poster Design

NASA Astrophysics Data System (ADS)

Star Cartier, Kimberly Michelle; Zhao, Ming; Beatty, Thomas G.; Morehead, Robert C.; Jontof-Hutter, Daniel

2016-01-01

This meta-poster illustrates how good poster design can effectively communicate scientific ideas to a broad professional audience. Inclusion of illustrative fugues supplemented by concise explanations of scientific information will provide a clear overview of your science to aid your oral pitch.

10 CFR 603.1005 - General responsibilities.

Code of Federal Regulations, 2013 CFR

2013-01-01

... incorporate clauses from the Federal Acquisition Regulation (48 CFR parts 1-53) or Department of Energy Acquisition Regulation (48 CFR parts 901-970) because those provisions are designed for procurement contracts...) Be written in clear and concise language, to minimize potential ambiguity. ...

10 CFR 603.1005 - General responsibilities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... incorporate clauses from the Federal Acquisition Regulation (48 CFR parts 1-53) or Department of Energy Acquisition Regulation (48 CFR parts 901-970) because those provisions are designed for procurement contracts...) Be written in clear and concise language, to minimize potential ambiguity. ...

10 CFR 603.1005 - General responsibilities.

Code of Federal Regulations, 2012 CFR

2012-01-01

... incorporate clauses from the Federal Acquisition Regulation (48 CFR parts 1-53) or Department of Energy Acquisition Regulation (48 CFR parts 901-970) because those provisions are designed for procurement contracts...) Be written in clear and concise language, to minimize potential ambiguity. ...

10 CFR 603.1005 - General responsibilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... incorporate clauses from the Federal Acquisition Regulation (48 CFR parts 1-53) or Department of Energy Acquisition Regulation (48 CFR parts 901-970) because those provisions are designed for procurement contracts...) Be written in clear and concise language, to minimize potential ambiguity. ...

36 CFR 218.2 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... ADMINISTRATIVE REVIEW PROCESSES Predecisional Administrative Review Process for Hazardous Fuel Reduction Projects... reduction project: A hazardous fuel reduction project authorized by the Healthy Forests Restoration Act of... reduction project pursuant to the HFRA. Decision notice (DN): A concise written record of a responsible...

36 CFR 220.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... environmental impact statement (EIS) or environmental assessment (EA). Decision notice. A concise written record... ENVIRONMENTAL POLICY ACT (NEPA) COMPLIANCE § 220.3 Definitions. The following definitions supplement, by adding... about natural resource systems is sometimes uncertain. Decision document. A record of decision, decision...

Media: A Pocket Guide.

ERIC Educational Resources Information Center

Arrasjid, Harun; Arrasjid, Dorine Audrey

An attempt has been made to provide a concise but comprehensive guide to instructional media for instructors, students, and teachers. Topics covered include audio learning systems, overhead projection, opaque projection, slide and filmstrip projection, projection surfaces, chalkboards and markboards, graphics, models, duplicating, motion pictures,…

Synthesis of labeled meropenem for the analysis of M. tuberculosis transpeptidases

PubMed Central

Kastrinsky, David B.; Barry, Clifton E.

2009-01-01

A concise synthesis of 14C labeled meropenem prepared from 14C dimethylamine hydrochloride is described. Using a similar reaction sequence, the meropenem nucleus was also attached to biotin providing a probe for protein interaction studies. PMID:20161438

Curriculum Resources.

ERIC Educational Resources Information Center

Thompson, Norma H.

1988-01-01

Discusses an article which presents a concise discussion of secular humanism. Reviews additional materials on censorship from the perspective of the new religious right, the fundamentalists, and public policy and the law. The sources provide background to enhance teaching about secular humanism and textbook censorship. (SLM)

Roundhouse Diagrams.

ERIC Educational Resources Information Center

Ward, Robin E.; Wandersee, James

2000-01-01

Students must understand key concepts through reasoning, searching out related concepts, and making connections within multiple systems to learn science. The Roundhouse diagram was developed to be a concise, holistic, graphic representation of a science topic, process, or activity. Includes sample Roundhouse diagrams, a diagram checklist, and…

75 FR 19340 - Wireless Technologies, Devices, and Services

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-14

... Technologies, Devices, and Services AGENCY: Federal Communications Commission. ACTION: Proposed rule. SUMMARY... technologies, devices, and services. Specifically, the Commission seeks comment regarding particular changes to... concise rules that facilitate new wireless technologies, devices and services, and are easy for the public...

76 FR 14442 - 60-Day Notice of Proposed Information Collection: DS 6561 Pre-Assignment for Overseas Duty for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-16

... automated collection techniques or other forms of technology. Abstract of proposed collection: The DS 6561 form provides a concise summary of basic medical history, lab tests and physical examination. Since...

Role of Grain Boundaries under Long-Time Radiation

NASA Astrophysics Data System (ADS)

Zhu, Yichao; Luo, Jing; Guo, Xu; Xiang, Yang; Chapman, Stephen Jonathan

2018-06-01

Materials containing a high proportion of grain boundaries offer significant potential for the development of radiation-resistant structural materials. However, a proper understanding of the connection between the radiation-induced microstructural behavior of a grain boundary and its impact at long natural time scales is still missing. In this Letter, point defect absorption at interfaces is summarized by a jump Robin-type condition at a coarse-grained level, wherein the role of interface microstructure is effectively taken into account. Then a concise formula linking the sink strength of a polycrystalline aggregate with its grain size is introduced and is well compared with experimental observation. Based on the derived model, a coarse-grained formulation incorporating the coupled evolution of grain boundaries and point defects is proposed, so as to underpin the study of long-time morphological evolution of grains induced by irradiation. Our simulation results suggest that the presence of point defect sources within a grain further accelerates its shrinking process, and radiation tends to trigger the extension of twin boundary sections.

Chemistry in Confinement: Copper and Palladium Catalyzed Ecofriendly Organic Transformations within Porous Frameworks.

PubMed

Kumar, Basuvaraj Suresh; Pitchumani, Kasi

2018-05-01

A concise account on the use of transition metals copper (Cu) and palladium (Pd), as their cations as well as nanoparticles exchanged/immobilized onto porous frameworks such as zeolites, metal organic frameworks (MOFs), covalent organic polymers (COPs) and hollow nanostructures, functioning as catalysts in organic synthesis is presented. This biomimetic account, "focusing on catalytic systems in confinement" within zero-dimensional microenvironments and second sphere coordination covers primarily results from our group on N-sulfonylketenimine mediated cycloaddition, hydrogenation and C-C bond forming reactions, thus providing an interesting insight into the versatility and utility of these Cu and Pd catalysts. Other significant advantages and green credentials of confinement such as stability, selectivity, reusability, promotion of multicomponent reactions, use of green solvents, atom economy, and use of ambient conditions are highlighted at appropriate places. In the final section, our views on the current achievements and the future prospects in this area are summarized. © 2018 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Aquatic toxicity information retrieval data base (AQUIRE for non-vms) (1600 bpi). Data file

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The purpose of AQUIRE is to provide scientists and managers quick access to a comprehensive, systematic, computerized compilation of aquatic toxicity data. During 1992 and early 1993, nine data updates were made to the AQUIRE system. AQUIRE now contains 109,338 individual aquatic toxicity test results for 5,159 chemicals, 2,429 organisms, and over 160 endpoints reviewed from 7,517 publications. New features include a data selection option that permits searches that are restricted to data added or modified through any of the eight most recent updates, and a report generation (Full Record Detail) that displays the entire AQUIRE record for each testmore » identified in a search. Selection of the Full Record Detail feature allows the user to peruse all AQUIRE fields for a given test, including the information stored in the remarks section, while the standard AQUIRE output format presents selected data fields in a concise table. The standard report remains an available option for rapid viewing of system output.« less

Aquatic toxicity information retrieval data base (AQUIRE for non-vms) (6250 bpi). Data file

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The purpose of AQUIRE is to provide scientists and managers quick access to a comprehensive, systematic, computerized compilation of aquatic toxicity data. During 1992 and early 1993, nine data updates were made to the AQUIRE system. AQUIRE now contains 109,338 individual aquatic toxicity test results for 5,159 chemicals, 2,429 organisms, and over 160 endpoints reviewed from 7,517 publications. New features include a data selection option that permits searches that are restricted to data added or modified through any of the eight most recent updates, and a report generation (Full Record Detail) that displays the entire AQUIRE record for each testmore » identified in a search. Selection of the Full Record Detail feature allows the user to peruse all AQUIRE fields for a given test, including the information stored in the remarks section, while the standard AQUIRE output format presents selected data fields in a concise table. The standard report remains an available option for rapid viewing of system output.« less

Particle Physics, 2nd Edition

NASA Astrophysics Data System (ADS)

Martin, B. R.; Shaw, G.

1998-01-01

Particle Physics, Second Edition is a concise and lucid account of the fundamental constituents of matter. The standard model of particle physics is developed carefully and systematically, without heavy mathematical formalism, to make this stimulating subject accessible to undergraduate students. Throughout, the emphasis is on the interpretation of experimental data in terms of the basic properties of quarks and leptons, and extensive use is made of symmetry principles and Feynman diagrams, which are introduced early in the book. The Second Edition brings the book fully up to date, including the discovery of the top quark and the search for the Higgs boson. A final short chapter is devoted to the continuing search for new physics beyond the standard model. Particle Physics, Second Edition features: * A carefully structured and written text to help students understand this exciting and demanding subject. * Many worked examples and problems to aid student learning. Hints for solving the problems are given in an Appendix. * Optional "starred" sections and appendices, containing more specialised and advanced material for the more ambitious reader.

Depleted Uranium and Human Health.

PubMed

Faa, Armando; Gerosa, Clara; Fanni, Daniela; Floris, Giuseppe; Eyken, Peter V; Lachowicz, Joanna I; Nurchi, Valeria M

2018-01-01

Depleted uranium (DU) is generally considered an emerging pollutant, first extensively introduced into environment in the early nineties in Iraq, during the military operation called "Desert Storm". DU has been hypothesized to represent a hazardous element both for soldiers exposed as well as for the inhabitants of the polluted areas in the war zones. In this review, the possible consequences on human health of DU released in the environment are critically analyzed. In the first part, the chemical properties of DU and the principal civil and military uses are summarized. A concise analysis of the mechanisms underlying absorption, blood transport, tissue distribution and excretion of DU in the human body is the subject of the second part of this article. The following sections deal with pathological condition putatively associated with overexposure to DU. Developmental and birth defects, the Persian Gulf syndrome, and kidney diseases that have been associated to DU are the arguments treated in the third section. Finally, data regarding DU exposure and cancer insurgence will be critically analyzed, including leukemia/lymphoma, lung cancer, uterine cervix cancer, breast cancer, bladder cancer and testicular cancer. The aim of the authors is to give a contribution to the debate on DU and its effects on human health and disease. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

77 FR 61279 - Approval and Promulgation of Implementation Plans; Mississippi; 110(a)(2)(G) Infrastructure...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-09

... section 110(a)(2)(G). EPA's July 31, 2012 (77 FR 45320), proposed approval was contingent upon Mississippi.... This SIP revision was submitted to address Clean Air Act (CAA or Act) section 110(a)(2)(G). Specifically, EPA is approving Mississippi's July 26, 2012, submission addressing section 110(a)(2)(G), of the...

Taiwan: Background Notes Series.

ERIC Educational Resources Information Center

Reams, Joanne Reppert

Concise background information on Taiwan is provided. The publication begins with a profile of Taiwan, discussing the people, geography, political establishment, and economy. A map of the country is provided. The bulk of the publication then provides more detailed information on Taiwan's people, geography, history, administration, political…

Constraint Reasoning Over Strings

NASA Technical Reports Server (NTRS)

Koga, Dennis (Technical Monitor); Golden, Keith; Pang, Wanlin

2003-01-01

This paper discusses an approach to representing and reasoning about constraints over strings. We discuss how many string domains can often be concisely represented using regular languages, and how constraints over strings, and domain operations on sets of strings, can be carried out using this representation.

A concise history of central venous access.

PubMed

Beheshti, Michael V

2011-12-01

Central venous access has become a mainstay of modern interventional radiology practice. Its history has paralleled and enabled many current medical therapies. This short overview provides an interesting historical perspective of these increasingly common interventional procedures. Copyright © 2011 Elsevier Inc. All rights reserved.

Phytoremediation of Contaminated Soil and Ground Water at Hazardous Waste Sites

EPA Pesticide Factsheets

The purpose of this issue paper is to provide a concise discussion of the processes associated with the use of phytoremediation as a cleanup or containment technique for remediation of hazardous waste sites. Introductory material on plant processes is ...

CEIS: Does the Foundation for a Nationwide Information System for Education Already Exist?

ERIC Educational Resources Information Center

Journal of Educational Data Processing, 1974

1974-01-01

Complete but concise picture of the California Education Information System, how it developed, its current status, its basic features, and a description of its contents. Covers design, developmental history, business subsystem, pupil subsystem, and a summary. (Author)

Theoretical Foundations of Learning Environments. Second Edition

ERIC Educational Resources Information Center

Jonassen, David, Ed.; Land, Susan, Ed.

2012-01-01

"Theoretical Foundations of Learning Environments" provides students, faculty, and instructional designers with a clear, concise introduction to the major pedagogical and psychological theories and their implications for the design of new learning environments for schools, universities, or corporations. Leading experts describe the most…

78 FR 8195 - Biweekly Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-05

... of the bases for the contention and a concise statement of the alleged facts or expert opinion which..., ``Allowable Value for Primary Containment and Drywell Isolation Instrumentation,'' Function 3.c, ``Reactor Core Isolation Cooling (RCIC) Steam Supply Line Pressure--Low.'' This TS allowable value will be...

Federal Election Commission.

ERIC Educational Resources Information Center

Elliot, Lee Ann

1996-01-01

Presents a concise overview of the responsibilities, membership, structure, and requirements of the Federal Election Commission (FEC). Created in 1974, the FEC oversees the financial activities of candidates and political parties. Discusses corporate and union political action committees (PACs) as well as contribution limits and prohibitions. (MJP)

Priority Techniques for High Occupancy Vehicles : State-of-the-Art Overview

DOT National Transportation Integrated Search

1975-11-01

The report, part of a series of publications based on research and development efforts is a concise state-of-the-art overview of priority techniques for high occupancy vehicles (buses, carpools, and vanpools). The report identifies and summarizes sel...

The Independent Music Teacher: Practice and Preparation.

ERIC Educational Resources Information Center

Uszler, Marienne

1996-01-01

Provides a concise overview of the working conditions and challenges faced by independent music teachers (IMT). Most IMTs function in a number of capacities, as performer, teacher, and entrepreneur. Discusses changing trends in employment, including computer technology and the move for national certification. (MJP)

Marxism and Liberation Theology.

ERIC Educational Resources Information Center

Hudelson, Richard

1986-01-01

Provides a concise summary of the main features of Marxism and challenges the thesis of the Vatican's "Instruction on Certain Aspects of the Theology of Liberation" that any use of Marxist categories or analysis entails a wholesale acceptance of Marxist philosophy, with its atheistic implications. (Author/ABB)

Disposition and Mechanisms of Toxicities of Metals and Metalloids

EPA Science Inventory

Dr. Hughes will provide a concise overview of general disposition (e.g., absorption) and mechanisms of toxicity of metal toxicity (e.g., direct interaction with functional groups of critical proteins, generation of reactive oxygen species, and alteration of cell signaling pathway...

Commuter choice primer : an employer's guide to implementing effective commuter choice programs

DOT National Transportation Integrated Search

2003-01-01

The Commuter Choice Primer is intended to be a concise, user-friendly reference guide for employers and transportation professionals to developing and implementing worksite commuter choice programs. It is available on-line in both HTML and PDF format...

Staphylococcus aureus

USDA-ARS?s Scientific Manuscript database

There is a need, in addition to the peer-reviewed research publications, for a concise monograph that provides a thoughtful synthesis of the genome sequencing data of key etiologic agents for food borne disease, with a focus on the novel, interesting, and potentially useful aspects of the genome se...

Study of Direct RF Injection on Microcontroller

DTIC Science & Technology

2013-06-06

TASK NUMBER PPM00010812 5f. WORK UNIT NUMBER EF002775 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) The University of Texas at Dallas Dept. of...Electrical Engineering Richardson, TX 75080 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS...test board and micro-instruction. 2.3 Organization of Report Section 3.0 describes the experiment procedure for direct RF injection. Section 4.0

The City Blueprint Approach: Urban Water Management and Governance in Cities in the U.S.

NASA Astrophysics Data System (ADS)

Feingold, Daniel; Koop, Stef; van Leeuwen, Kees

2018-01-01

In this paper, we assess the challenges of water, waste and climate change in six cities across the U.S.: New York City, Boston, Milwaukee, Phoenix, Portland and Los Angeles. We apply the City Blueprint® Approach which consists of three indicator assessments: (1) the Trends and Pressures Framework (TPF), (2) the City Blueprint Framework (CBF) and (3) the water Governance Capacity Framework (GCF). The TPF summarizes the main social, environmental and financial pressures that may impede water management. The CBF provides an integrated overview of the management performances within the urban watercycle. Finally, the GCF provides a framework to identify key barriers and opportunities to develop governance capacity. The GCF has only been applied in NYC. Results show that all cities face pressures from heat risk. The management performances regarding resource efficiency and resource recovery from wastewater and solid waste show considerable room for improvement. Moreover, stormwater separation, infrastructure maintenance and green space require improvement in order to achieve a resilient urban watercycle. Finally, in New York City, the GCF results show that learning through smart monitoring, evaluation and cross-stakeholder learning is a limiting condition that needs to be addressed. We conclude that the City Blueprint Approach has large potential to assist cities in their strategic planning and exchange of knowledge, experiences and lessons. Because the methodology is well-structured, easy to understand, and concise, it may bridge the gap between science, policy and practice. It could therefore enable other cities to address their challenges of water, waste and climate change.

Concise review: managing genotoxicity in the therapeutic modification of stem cells.

PubMed

Baum, Christopher; Modlich, Ute; Göhring, Gudrun; Schlegelberger, Brigitte

2011-10-01

The therapeutic use of procedures for genetic stem cell modification is limited by potential adverse events related to uncontrolled mutagenesis. Prominent findings have been made in hematopoietic gene therapy, demonstrating the risk of clonal, potentially malignant outgrowth on the basis of mutations acquired during or after therapeutic genome modification. The incidence and the growth rate of insertional mutants have been linked to the "stemness" of the target cells and vector-related features such as the integration pattern, the architecture, and the exact content of transgene cassettes. Milieu factors supporting the survival and expansion of mutants may eventually allow oncogenic progression. Similar concerns apply for medicinal products based on pluripotent stem cells. Focusing on the genetic stress induced by insertional mutagenesis and culture adaptation, we propose four conclusions. (a) Mutations occurring in the production of stem cell-based medicines may be unavoidable and need to be classified according to their risk to trigger the formation of clones that are sufficiently long-lived and mitotically active to acquire secondary transforming mutations. (b) The development of rational prevention strategies depends upon the identification of the specific mutations forming such "dominant clones" (which can also be addressed as cancer stem cell precursors) and a better knowledge of the mechanisms underlying their creation, expansion, and homeostatic control. (c) Quantitative assay systems are required to assess the practical value of preventive actions. (d) Improved approaches for the genetic modification of stem cells can address all critical steps in the origin and growth control of mutants. Copyright © 2011 AlphaMed Press.

The City Blueprint Approach: Urban Water Management and Governance in Cities in the U.S.

PubMed

Feingold, Daniel; Koop, Stef; van Leeuwen, Kees

2018-01-01

In this paper, we assess the challenges of water, waste and climate change in six cities across the U.S.: New York City, Boston, Milwaukee, Phoenix, Portland and Los Angeles. We apply the City Blueprint ® Approach which consists of three indicator assessments: (1) the Trends and Pressures Framework (TPF), (2) the City Blueprint Framework (CBF) and (3) the water Governance Capacity Framework (GCF). The TPF summarizes the main social, environmental and financial pressures that may impede water management. The CBF provides an integrated overview of the management performances within the urban watercycle. Finally, the GCF provides a framework to identify key barriers and opportunities to develop governance capacity. The GCF has only been applied in NYC. Results show that all cities face pressures from heat risk. The management performances regarding resource efficiency and resource recovery from wastewater and solid waste show considerable room for improvement. Moreover, stormwater separation, infrastructure maintenance and green space require improvement in order to achieve a resilient urban watercycle. Finally, in New York City, the GCF results show that learning through smart monitoring, evaluation and cross-stakeholder learning is a limiting condition that needs to be addressed. We conclude that the City Blueprint Approach has large potential to assist cities in their strategic planning and exchange of knowledge, experiences and lessons. Because the methodology is well-structured, easy to understand, and concise, it may bridge the gap between science, policy and practice. It could therefore enable other cities to address their challenges of water, waste and climate change.

Policies to Enhance Prescribing Efficiency in Europe: Findings and Future Implications

PubMed Central

Godman, Brian; Shrank, William; Andersen, Morten; Berg, Christian; Bishop, Iain; Burkhardt, Thomas; Garuoliene, Kristina; Herholz, Harald; Joppi, Roberta; Kalaba, Marija; Laius, Ott; Lonsdale, Julie; Malmström, Rickard E.; Martikainen, Jaana E.; Samaluk, Vita; Sermet, Catherine; Schwabe, Ulrich; Teixeira, Inês; Tilson, Lesley; Tulunay, F. Cankat; Vlahović-Palčevski, Vera; Wendykowska, Kamila; Wettermark, Bjorn; Zara, Corinne; Gustafsson, Lars L.

2010-01-01

Introduction: European countries need to learn from each other to address unsustainable increases in pharmaceutical expenditures. Objective: To assess the influence of the many supply and demand-side initiatives introduced across Europe to enhance prescribing efficiency in ambulatory care. As a result provide future guidance to countries. Methods: Cross national retrospective observational study of utilization (DDDs – defined daily doses) and expenditure (Euros and local currency) of proton pump inhibitors (PPIs) and statins among 19 European countries and regions principally from 2001 to 2007. Demand-side measures categorized under the “4Es” – education engineering, economics, and enforcement. Results: Instigating supply side initiatives to lower the price of generics combined with demand-side measures to enhance their prescribing is important to maximize prescribing efficiency. Just addressing one component will limit potential efficiency gains. The influence of demand-side reforms appears additive, with multiple initiatives typically having a greater influence on increasing prescribing efficiency than single measures apart from potentially “enforcement.” There are also appreciable differences in expenditure (€/1000 inhabitants/year) between countries. Countries that have not introduced multiple demand side measures to counteract commercial pressures to enhance the prescribing of generics have seen considerably higher expenditures than those that have instigated a range of measures. Conclusions: There are considerable opportunities for European countries to enhance their prescribing efficiency, with countries already learning from each other. The 4E methodology allows European countries to concisely capture the range of current demand-side measures and plan for the future knowing that initiatives can be additive to further enhance their prescribing efficiency. PMID:21833180

Guidelines for the Diagnosis and Management of Food Allergy in the United States

PubMed Central

Boyce, Joshua A.; Assa'ad, Amal; Burks, A. Wesley; Jones, Stacie M.; Sampson, Hugh A.; Wood, Robert A.; Plaut, Marshall; Cooper, Susan F.; Fenton, Matthew J.; Arshad, S. Hasan; Bahna, Sami L.; Beck, Lisa A.; Byrd-Bredbenner, Carol; Camargo, Carlos A.; Eichenfield, Lawrence; Furuta, Glenn T.; Hanifin, Jon M.; Jones, Carol; Kraft, Monica; Levy, Bruce D.; Lieberman, Phil; Luccioli, Stefano; McCall, Kathleen M.; Schneider, Lynda C.; Simon, Ronald A.; Simons, F. Estelle R.; Teach, Stephen J.; Yawn, Barbara P.; Schwaninger, Julie M.

2014-01-01

Food allergy is an important public health problem that affects children and adults and may be increasing in prevalence. Despite the risk of severe allergic reactions and even death, there is no current treatment for food allergy: the disease can only be managed by allergen avoidance or treatment of symptoms. The diagnosis and management of food allergy also may vary from one clinical practice setting to another. Finally, because patients frequently confuse nonallergic food reactions, such as food intolerance, with food allergies, there is an unfounded belief among the public that food allergy prevalence is higher than it truly is. In response to these concerns, the National Institute of Allergy and Infectious Diseases, working with 34 professional organizations, federal agencies, and patient advocacy groups, led the development of clinical guidelines for the diagnosis and management of food allergy. These Guidelines are intended for use by a wide variety of health care professionals, including family practice physicians, clinical specialists, and nurse practitioners. The Guidelines include a consensus definition for food allergy, discuss comorbid conditions often associated with food allergy, and focus on both IgE-mediated and non-IgE-mediated reactions to food. Topics addressed include the epidemiology, natural history, diagnosis, and management of food allergy, as well as the management of severe symptoms and anaphylaxis. These Guidelines provide 43 concise clinical recommendations and additional guidance on points of current controversy in patient management. They also identify gaps in the current scientific knowledge to be addressed through future research. PMID:21134576

Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel.

PubMed

Boyce, Joshua A; Assa'ad, Amal; Burks, A Wesley; Jones, Stacie M; Sampson, Hugh A; Wood, Robert A; Plaut, Marshall; Cooper, Susan F; Fenton, Matthew J; Arshad, S Hasan; Bahna, Sami L; Beck, Lisa A; Byrd-Bredbenner, Carol; Camargo, Carlos A; Eichenfield, Lawrence; Furuta, Glenn T; Hanifin, Jon M; Jones, Carol; Kraft, Monica; Levy, Bruce D; Lieberman, Phil; Luccioli, Stefano; McCall, Kathleen M; Schneider, Lynda C; Simon, Ronald A; Simons, F Estelle R; Teach, Stephen J; Yawn, Barbara P; Schwaninger, Julie M

2010-12-01

Food allergy is an important public health problem that affects children and adults and may be increasing in prevalence. Despite the risk of severe allergic reactions and even death, there is no current treatment for food allergy: the disease can only be managed by allergen avoidance or treatment of symptoms. The diagnosis and management of food allergy also may vary from one clinical practice setting to another. Finally, because patients frequently confuse nonallergic food reactions, such as food intolerance, with food allergies, there is an unfounded belief among the public that food allergy prevalence is higher than it truly is. In response to these concerns, the National Institute of Allergy and Infectious Diseases, working with 34 professional organizations, federal agencies, and patient advocacy groups, led the development of clinical guidelines for the diagnosis and management of food allergy. These Guidelines are intended for use by a wide variety of health care professionals, including family practice physicians, clinical specialists, and nurse practitioners. The Guidelines include a consensus definition for food allergy, discuss comorbid conditions often associated with food allergy, and focus on both IgE-mediated and non-IgE-mediated reactions to food. Topics addressed include the epidemiology, natural history, diagnosis, and management of food allergy, as well as the management of severe symptoms and anaphylaxis. These Guidelines provide 43 concise clinical recommendations and additional guidance on points of current controversy in patient management. They also identify gaps in the current scientific knowledge to be addressed through future research. Published by Mosby, Inc.

The feasibility of implementing a communication skills training course in pediatric hematology/oncology fellowship.

PubMed

Weintraub, Lauren; Figueiredo, Lisa; Roth, Michael; Levy, Adam

Communication skills are a competency highlighted by the Accreditation Council on Graduate Medical Education; yet, little is known about the frequency with which trainees receive formal training or what programs are willing to invest. We sought to answer this question and designed a program to address identified barriers. We surveyed pediatric fellowship program directors from all disciplines and, separately, pediatric hematology/oncology fellowship program directors to determine current use of formal communication skills training. At our institution, we piloted a standardized patient (SP)-based communication skills training program for pediatric hematology/oncology fellows. Twenty-seven pediatric hematology/oncology program directors and 44 pediatric program directors participated in the survey, of which 56% and 48%, respectively, reported having an established, formal communication skills training course. Multiple barriers to implementation of a communication skills course were identified, most notably time and cost. In the pilot program, 13 pediatric hematology/oncology fellows have participated, and 9 have completed all 3 years of training. Precourse assessment demonstrated fellows had limited comfort in various areas of communication. Following course completion, there was a significant increase in self-reported comfort and/or skill level in such areas of communication, including discussing a new diagnosis (p =.0004), telling a patient they are going to die (p =.005), discussing recurrent disease (p <.001), communicating a poor prognosis (p =.002), or responding to anger (p ≤.001). We have designed a concise communication skills training program, which addresses identified barriers and can feasibly be implemented in pediatric hematology/oncology fellowship.

The NMatrix, a new method of presenting statistics, displays the characteristics of medicines with similar effects used in the treatment of lumbar spinal stenosis concisely and clearly, facilitating the selection of appropriate medications.

PubMed

Nakamura, Masao

2015-07-01

It is often difficult to compare the characteristics of a medicine with those of others based on common standards, whereas the application of rational standards would be expected to facilitate the comparison of medicines with similar effects. The present study was conducted to clarify the characteristics of individual medicines and to examine whether rational standards allow the most appropriate medicines to be chosen. Participants diagnosed with lumbar spinal stenosis (LSS) were assessed for QOL and ADL based on the Roland-Morris Disability Questionnaire, JOA score, VAS, and the presence of intermittent claudication (IC). Four medicines--beraprost sodium, ethyl icosapentate (EPA), sarpogrelate hydrochloride, and limaprost alfadex (PGE1)--were prescribed in a random manner. These four medicines were assessed independently in four studies using the same study design and size in each case. Using the NMatrix, the characteristics of the four medicines and the results of mutual comparisons could be displayed concisely and clearly in one matrix based on significance levels. This work involved analyzing pooled data from the four studies. All four medicines improved IC--one of the characteristic symptoms of LSS--by 12 weeks after administration. PGE1 required more time than the other medicines to affect IC. EPA appeared to almost significantly ameliorate some items at every point, though the evidence was insufficient. The NMatrix concisely and clearly displays the characteristics of "medicines with similar effects" for the treatment of lumbar spinal stenosis, and can help physicians to choose the optimal medicine based on rational criteria for individual patients, according to their symptoms and progress.

MARRVEL: Integration of Human and Model Organism Genetic Resources to Facilitate Functional Annotation of the Human Genome.

PubMed

Wang, Julia; Al-Ouran, Rami; Hu, Yanhui; Kim, Seon-Young; Wan, Ying-Wooi; Wangler, Michael F; Yamamoto, Shinya; Chao, Hsiao-Tuan; Comjean, Aram; Mohr, Stephanie E; Perrimon, Norbert; Liu, Zhandong; Bellen, Hugo J

2017-06-01

One major challenge encountered with interpreting human genetic variants is the limited understanding of the functional impact of genetic alterations on biological processes. Furthermore, there remains an unmet demand for an efficient survey of the wealth of information on human homologs in model organisms across numerous databases. To efficiently assess the large volume of publically available information, it is important to provide a concise summary of the most relevant information in a rapid user-friendly format. To this end, we created MARRVEL (model organism aggregated resources for rare variant exploration). MARRVEL is a publicly available website that integrates information from six human genetic databases and seven model organism databases. For any given variant or gene, MARRVEL displays information from OMIM, ExAC, ClinVar, Geno2MP, DGV, and DECIPHER. Importantly, it curates model organism-specific databases to concurrently display a concise summary regarding the human gene homologs in budding and fission yeast, worm, fly, fish, mouse, and rat on a single webpage. Experiment-based information on tissue expression, protein subcellular localization, biological process, and molecular function for the human gene and homologs in the seven model organisms are arranged into a concise output. Hence, rather than visiting multiple separate databases for variant and gene analysis, users can obtain important information by searching once through MARRVEL. Altogether, MARRVEL dramatically improves efficiency and accessibility to data collection and facilitates analysis of human genes and variants by cross-disciplinary integration of 18 million records available in public databases to facilitate clinical diagnosis and basic research. Copyright © 2017 American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

Design of a concise Féry-prism hyperspectral imaging system based on multi-configuration

NASA Astrophysics Data System (ADS)

Dong, Wei; Nie, Yun-feng; Zhou, Jin-song

2013-08-01

In order to meet the needs of space borne and airborne hyperspectral imaging system for light weight, simplification and high spatial resolution, a novel design of Féry-prism hyperspectral imaging system based on Zemax multi-configuration method is presented. The novel structure is well arranged by analyzing optical monochromatic aberrations theoretically, and the optical structure of this design is concise. The fundamental of this design is Offner relay configuration, whereas the secondary mirror is replaced by Féry-prism with curved surfaces and a reflective front face. By reflection, the light beam passes through the Féry-prism twice, which promotes spectral resolution and enhances image quality at the same time. The result shows that the system can achieve light weight and simplification, compared to other hyperspectral imaging systems. Composed of merely two spherical mirrors and one achromatized Féry-prism to perform both dispersion and imaging functions, this structure is concise and compact. The average spectral resolution is 6.2nm; The MTFs for 0.45~1.00um spectral range are greater than 0.75, RMSs are less than 2.4um; The maximal smile is less than 10% pixel, while the keystones is less than 2.8% pixel; image quality approximates the diffraction limit. The design result shows that hyperspectral imaging system with one modified Féry-prism substituting the secondary mirror of Offner relay configuration is feasible from the perspective of both theory and practice, and possesses the merits of simple structure, convenient optical alignment, and good image quality, high resolution in space and spectra, adjustable dispersive nonlinearity. The system satisfies the requirements of airborne or space borne hyperspectral imaging system.

The Sequenced Angiosperm Genomes and Genome Databases.

PubMed

Chen, Fei; Dong, Wei; Zhang, Jiawei; Guo, Xinyue; Chen, Junhao; Wang, Zhengjia; Lin, Zhenguo; Tang, Haibao; Zhang, Liangsheng

2018-01-01

Angiosperms, the flowering plants, provide the essential resources for human life, such as food, energy, oxygen, and materials. They also promoted the evolution of human, animals, and the planet earth. Despite the numerous advances in genome reports or sequencing technologies, no review covers all the released angiosperm genomes and the genome databases for data sharing. Based on the rapid advances and innovations in the database reconstruction in the last few years, here we provide a comprehensive review for three major types of angiosperm genome databases, including databases for a single species, for a specific angiosperm clade, and for multiple angiosperm species. The scope, tools, and data of each type of databases and their features are concisely discussed. The genome databases for a single species or a clade of species are especially popular for specific group of researchers, while a timely-updated comprehensive database is more powerful for address of major scientific mysteries at the genome scale. Considering the low coverage of flowering plants in any available database, we propose construction of a comprehensive database to facilitate large-scale comparative studies of angiosperm genomes and to promote the collaborative studies of important questions in plant biology.

Propagation effects handbook for satellite systems design. A summary of propagation impairments on 10 to 100 GHz satellite links with techniques for system design

NASA Technical Reports Server (NTRS)

Ippolito, L. J.; Kaul, R. D.; Wallace, R. G.

1983-01-01

This Propagation Handbook provides satellite system engineers with a concise summary of the major propagation effects experienced on Earth-space paths in the 10 to 100 GHz frequency range. The dominant effect, attenuation due to rain, is dealt with in some detail, in terms of both experimental data from measurements made in the U.S. and Canada, and the mathematical and conceptual models devised to explain the data. In order to make the Handbook readily usable to many engineers, it has been arranged in two parts. Chapters 2-5 comprise the descriptive part. They deal in some detail with rain systems, rain and attenuation models, depolarization and experimental data. Chapters 6 and 7 make up the design part of the Handbook and may be used almost independently of the earlier chapters. In Chapter 6, the design techniques recommended for predicting propagation effects in Earth-space communications systems are presented. Chapter 7 addresses the questions of where in the system design process the effects of propagation should be considered, and what precautions should be taken when applying the propagation results.

An efficient ensemble learning method for gene microarray classification.

PubMed

Osareh, Alireza; Shadgar, Bita

2013-01-01

The gene microarray analysis and classification have demonstrated an effective way for the effective diagnosis of diseases and cancers. However, it has been also revealed that the basic classification techniques have intrinsic drawbacks in achieving accurate gene classification and cancer diagnosis. On the other hand, classifier ensembles have received increasing attention in various applications. Here, we address the gene classification issue using RotBoost ensemble methodology. This method is a combination of Rotation Forest and AdaBoost techniques which in turn preserve both desirable features of an ensemble architecture, that is, accuracy and diversity. To select a concise subset of informative genes, 5 different feature selection algorithms are considered. To assess the efficiency of the RotBoost, other nonensemble/ensemble techniques including Decision Trees, Support Vector Machines, Rotation Forest, AdaBoost, and Bagging are also deployed. Experimental results have revealed that the combination of the fast correlation-based feature selection method with ICA-based RotBoost ensemble is highly effective for gene classification. In fact, the proposed method can create ensemble classifiers which outperform not only the classifiers produced by the conventional machine learning but also the classifiers generated by two widely used conventional ensemble learning methods, that is, Bagging and AdaBoost.

Andrographis paniculata (Burm. f.) Wall. ex Nees: A Review of Ethnobotany, Phytochemistry, and Pharmacology

PubMed Central

Sule, Abubakar; Rahman, K. M. Hafizur

2014-01-01

As aboriginal sources of medications, medicinal plants are used from the ancient times. Andrographis paniculata is one of the highly used potential medicinal plants in the world. This plant is traditionally used for the treatment of common cold, diarrhoea, fever due to several infective cause, jaundice, as a health tonic for the liver and cardiovascular health, and as an antioxidant. It is also used to improve sexual dysfunctions and serve as a contraceptive. All parts of this plant are used to extract the active phytochemicals, but the compositions of phytoconstituents widely differ from one part to another and with place, season, and time of harvest. Our extensive data mining of the phytoconstituents revealed more than 55 ent-labdane diterpenoids, 30 flavonoids, 8 quinic acids, 4 xanthones, and 5 rare noriridoids. In this review, we selected only those compounds that pharmacology has already reported. Finally we focused on around 46 compounds for further discussion. We also discussed ethnobotany of this plant briefly. Recommendations addressing extraction process, tissue culture, and adventitious rooting techniques and propagation under abiotic stress conditions for improvement of phytoconstituents are discussed concisely in this paper. Further study areas on pharmacology are also proposed where needed. PMID:25950015

I'll take that to go: Big data bags and minimal identifiers for exchange of large, complex datasets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chard, Kyle; D'Arcy, Mike; Heavner, Benjamin D.

Big data workflows often require the assembly and exchange of complex, multi-element datasets. For example, in biomedical applications, the input to an analytic pipeline can be a dataset consisting thousands of images and genome sequences assembled from diverse repositories, requiring a description of the contents of the dataset in a concise and unambiguous form. Typical approaches to creating datasets for big data workflows assume that all data reside in a single location, requiring costly data marshaling and permitting errors of omission and commission because dataset members are not explicitly specified. We address these issues by proposing simple methods and toolsmore » for assembling, sharing, and analyzing large and complex datasets that scientists can easily integrate into their daily workflows. These tools combine a simple and robust method for describing data collections (BDBags), data descriptions (Research Objects), and simple persistent identifiers (Minids) to create a powerful ecosystem of tools and services for big data analysis and sharing. We present these tools and use biomedical case studies to illustrate their use for the rapid assembly, sharing, and analysis of large datasets.« less

Improving drug delivery technology for treating neurodegenerative diseases.

PubMed

Choonara, Yahya E; Kumar, Pradeep; Modi, Girish; Pillay, Viness

2016-07-01

Neurodegenerative diseases (NDs) represent intricate challenges for efficient uptake and transport of drugs to the brain mainly due to the restrictive blood-brain barrier (BBB). NDs are characterized by the loss of neuronal subtypes as sporadic and/or familial and several mechanisms of neurodegeneration have been identified. This review attempts to recap, organize and concisely evaluate the advanced drug delivery systems designed for treating common NDs. It highlights key research gaps and opinionates on new neurotherapies to overcome the BBB as an addition to the current treatments of countering oxidative stress, inflammation and apoptotic mechanisms. Current treatments do not fully address the biological, drug and therapeutic factors faced. This has led to the development of vogue treatments such as nose-to-brain technologies, bio-engineered systems, fusion protein chaperones, stem cells, gene therapy, use of natural compounds, neuroprotectants and even vaccines. However, failure of these treatments is mainly due to the BBB and non-specific delivery in the brain. In order to increase neuroavailability various advanced drug delivery systems provide promising alternatives that are able to augment the treatment of Alzheimer's disease and Parkinson's disease. However, much work is still required in this field beyond the preclinical testing phase.

Concise Review: Progress and Challenges in Using Human Stem Cells for Biological and Therapeutics Discovery: Neuropsychiatric Disorders.

PubMed

Panchision, David M

2016-03-01

In facing the daunting challenge of using human embryonic and induced pluripotent stem cells to study complex neural circuit disorders such as schizophrenia, mood and anxiety disorders, and autism spectrum disorders, a 2012 National Institute of Mental Health workshop produced a set of recommendations to advance basic research and engage industry in cell-based studies of neuropsychiatric disorders. This review describes progress in meeting these recommendations, including the development of novel tools, strides in recapitulating relevant cell and tissue types, insights into the genetic basis of these disorders that permit integration of risk-associated gene regulatory networks with cell/circuit phenotypes, and promising findings of patient-control differences using cell-based assays. However, numerous challenges are still being addressed, requiring further technological development, approaches to resolve disease heterogeneity, and collaborative structures for investigators of different disciplines. Additionally, since data obtained so far is on small sample sizes, replication in larger sample sets is needed. A number of individual success stories point to a path forward in developing assays to translate discovery science to therapeutics development. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

A practical framework for data management processes and their evaluation in population-based medical registries.

PubMed

Sariyar, M; Borg, A; Heidinger, O; Pommerening, K

2013-03-01

We present a framework for data management processes in population-based medical registries. Existing guidelines lack the concreteness we deem necessary for them to be of practical use, especially concerning the establishment of new registries. Therefore, we propose adjustments and concretisations with regard to data quality, data privacy, data security and registry purposes. First, we separately elaborate on the issues to be included into the framework and present proposals for their improvements. Thereafter, we provide a framework for medical registries based on quasi-standard-operation procedures. The main result is a concise and scientifically based framework that tries to be both broad and concrete. Within that framework, we distinguish between data acquisition, data storage and data presentation as sub-headings. We use the framework to categorise and evaluate the data management processes of a German cancer registry. The standardisation of data management processes in medical registries is important to guarantee high quality of the registered data, to enhance the realisation of purposes, to increase efficiency and to enable comparisons between registries. Our framework is destined to show how one central impediment for such standardisations - lack of practicality - can be addressed on scientific grounds.

MALDI matrices for low molecular weight compounds: an endless story?

PubMed

Calvano, Cosima Damiana; Monopoli, Antonio; Cataldi, Tommaso R I; Palmisano, Francesco

2018-04-23

Since its introduction in the 1980s, matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) has gained a prominent role in the analysis of high molecular weight biomolecules such as proteins, peptides, oligonucleotides, and polysaccharides. Its application to low molecular weight compounds has remained for long time challenging due to the spectral interferences produced by conventional organic matrices in the low m/z window. To overcome this problem, specific sample preparation such as analyte/matrix derivatization, addition of dopants, or sophisticated deposition technique especially useful for imaging experiments, have been proposed. Alternative approaches based on second generation (rationally designed) organic matrices, ionic liquids, and inorganic matrices, including metallic nanoparticles, have been the object of intense and continuous research efforts. Definite evidences are now provided that MALDI MS represents a powerful and invaluable analytical tool also for small molecules, including their quantification, thus opening new, exciting applications in metabolomics and imaging mass spectrometry. This review is intended to offer a concise critical overview of the most recent achievements about MALDI matrices capable of specifically address the challenging issue of small molecules analysis. Graphical abstract An ideal Book of matrices for MALDI MS of small molecules.

Hydrogel based cartilaginous tissue regeneration: recent insights and technologies.

PubMed

Chuah, Yon Jin; Peck, Yvonne; Lau, Jia En Josias; Hee, Hwan Tak; Wang, Dong-An

2017-03-28

Hydrogels have been extensively employed as an attractive biomaterial to address numerous existing challenges in the fields of regenerative medicine and research because of their unique properties such as the capability to encapsulate cells, high water content, ease of modification, low toxicity, injectability, in situ spatial fit and biocompatibility. These inherent properties have created many opportunities for hydrogels as a scaffold or a cell/drug carrier in tissue regeneration, especially in the field of cartilaginous tissue such as articular cartilage and intervertebral discs. A concise overview of the anatomy/physiology of these cartilaginous tissues and their pathophysiology, epidemiology and existing clinical treatments will be briefly described. This review article will discuss the current state-of-the-art of various polymers and developing strategies that are explored in establishing different technologies for cartilaginous tissue regeneration. In particular, an innovative approach to generate scaffold-free cartilaginous tissue via a transient hydrogel scaffolding system for disease modeling to pre-clinical trials will be examined. Following that, the article reviews numerous hydrogel-based medical implants used in clinical treatment of osteoarthritis and degenerated discs. Last but not least, the challenges and future directions of hydrogel based medical implants in the regeneration of cartilaginous tissue are also discussed.

Discrimination and health inequities.

PubMed

Krieger, Nancy

2014-01-01

In 1999, only 20 studies in the public health literature employed instruments to measure self-reported experiences of discrimination. Fifteen years later, the number of empirical investigations on discrimination and health easily exceeds 500, with these studies increasingly global in scope and focused on major types of discrimination variously involving race/ethnicity, indigenous status, immigrant status, gender, sexuality, disability, and age, separately and in combination. And yet, as I also document, even as the number of investigations has dramatically expanded, the scope remains narrow: studies remain focused primarily on interpersonal discrimination, and scant research investigates the health impacts of structural discrimination, a gap consonant with the limited epidemiologic research on political systems and population health. Accordingly, to help advance the state of the field, this updated review article: (a) briefly reviews definitions of discrimination, illustrated with examples from the United States; (b) discusses theoretical insights useful for conceptualizing how discrimination can become embodied and produce health inequities, including via distortion of scientific knowledge; (c) concisely summarizes extant evidence--both robust and inconsistent--linking discrimination and health; and (d) addresses several key methodological controversies and challenges, including the need for careful attention to domains, pathways, level, and spatiotemporal scale, in historical context.

Green Bonds and climate change: State of the art or artful dodge?

NASA Astrophysics Data System (ADS)

Queen, Irene T.

Debt-finance is a growing opportunity to fund environmental solutions. Green Bonds are being used by investors wishing to improve their Corporate Social Responsibility positions while maintaining valid returns on their investments. Based on the well-established bond-finance model, Green Bonds put money into diverse environmental projects addressing impacts from climate changes, depletion of natural resources, biodiversity loss, and pollution control. “Green” is a voluntary designation, based on a set of guidelines known as the Green Bond Principles. With varying degrees of clarity regarding their use and environmental impact and whether they are a viable solution to climate damages or merely a “greenwashed” ploy used by some issuers to appear more sustainable were questions examined as part of this research. A concise summary briefing (Appendix A), case study draft, and targeted public engagements were completed. Adaptability and responsiveness, sustainability, credibility, legitimacy, and opportunity for social transformation through the use of Green Bonds were reviewed using a case study analysis method. A unique pool of investment capital being mobilized by Green Bonds is emerging through motivated environmental investment coalitions. A review of the integrated impacts of Green Bonds as well as practical knowledge for their issuance is described here.

Image correlation based method for the analysis of collagen fibers patterns

NASA Astrophysics Data System (ADS)

Rosa, Ramon G. T.; Pratavieira, Sebastião.; Kurachi, Cristina

2015-06-01

The collagen fibers are one of the most important structural proteins in skin, being responsible for its strength and flexibility. It is known that their properties, like fibers density, ordination and mean diameter can be affected by several skin conditions, what makes these properties a good parameter to be used on the diagnosis and evaluation of skin aging, cancer, healing, among other conditions. There is, however, a need for methods capable of analyzing quantitatively the organization patterns of these fibers. To address this need, we developed a method based on the autocorrelation function of the images that allows the construction of vector field plots of the fibers directions and does not require any kind of curve fitting or optimization. The analyzed images were obtained through Second Harmonic Generation Imaging Microscopy. This paper presents a concise review on the autocorrelation function and some of its applications to image processing, details the developed method and the results obtained through the analysis of hystopathological slides of landrace porcine skin. The method has high accuracy on the determination of the fibers direction and presents high performance. We look forward to perform further studies keeping track of different skin conditions over time.

Peripheral Neuropathy: A Practical Approach to Diagnosis and Symptom Management.

PubMed

Watson, James C; Dyck, P James B

2015-07-01

Peripheral neuropathy is one of the most prevalent neurologic conditions encountered by physicians of all specialties. Physicians are faced with 3 distinct challenges in caring for patients with peripheral neuropathy: (1) how to efficiently and effectively screen (in less than 2 minutes) an asymptomatic patient for peripheral neuropathy when they have a disorder in which peripheral neuropathy is highly prevalent (eg, diabetes mellitus), (2) how to clinically stratify patients presenting with symptoms of neuropathy to determine who would benefit from specialty consultation and what testing is appropriate for those who do not need consultation, and (3) how to treat the symptoms of painful peripheral neuropathy. In this concise review, we address these 3 common clinical scenarios. Easily defined clinical patterns of involvement are used to identify patients in need of neurologic consultation, the yield of laboratory and other diagnostic testing is reviewed for the evaluation of length-dependent, sensorimotor peripheral neuropathies (the most common form of neuropathy), and an algorithmic approach with dosing recommendations is provided for the treatment of neuropathic pain associated with peripheral neuropathy. Copyright © 2015 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

The Sequenced Angiosperm Genomes and Genome Databases

PubMed Central

Chen, Fei; Dong, Wei; Zhang, Jiawei; Guo, Xinyue; Chen, Junhao; Wang, Zhengjia; Lin, Zhenguo; Tang, Haibao; Zhang, Liangsheng

2018-01-01

Angiosperms, the flowering plants, provide the essential resources for human life, such as food, energy, oxygen, and materials. They also promoted the evolution of human, animals, and the planet earth. Despite the numerous advances in genome reports or sequencing technologies, no review covers all the released angiosperm genomes and the genome databases for data sharing. Based on the rapid advances and innovations in the database reconstruction in the last few years, here we provide a comprehensive review for three major types of angiosperm genome databases, including databases for a single species, for a specific angiosperm clade, and for multiple angiosperm species. The scope, tools, and data of each type of databases and their features are concisely discussed. The genome databases for a single species or a clade of species are especially popular for specific group of researchers, while a timely-updated comprehensive database is more powerful for address of major scientific mysteries at the genome scale. Considering the low coverage of flowering plants in any available database, we propose construction of a comprehensive database to facilitate large-scale comparative studies of angiosperm genomes and to promote the collaborative studies of important questions in plant biology. PMID:29706973

NASA Contributions to the Development and Testing of Climate Indicators

NASA Astrophysics Data System (ADS)

Houser, P. R.; Leidner, A. K.; Tsaoussi, L.; Kaye, J. A.

2014-12-01

NASA is a major contributor the U.S. National Climate Assessment (NCA), a central component of the 2012-2022 U.S. Global Change Research Program's Strategic Plan. NASA supports a range of global climate and related environmental assessment activities through its data records, models, and model-produced data sets, as well as through involvement of agency personnel. These assessments provide important information on climate change and are used by policymakers, especially with the recent increased interest in climate vulnerability, impacts, and adaptation. Climate indicators provide a clear and concise way of communicating to the NCA audiences about not only status and trends of physical drivers of the climate system, but also the ecological and socioeconomic impacts, vulnerabilities, and responses to those drivers. NASA is enhancing its participation in future NCAs by encouraging the developing and testing of potential indicators that best address the needs expressed in the NCA indicator vision and that leverage NASA's capabilities. This presentation will highlight a suite of new climate indicators that draws significantly from NASA -produced data and/or modeling products, to support decisions related to impacts, adaptation, vulnerability, and mitigation associated with climate and global change.

Cardiac Radionuclide Imaging in Rodents: A Review of Methods, Results, and Factors at Play

PubMed Central

Cicone, Francesco; Viertl, David; Quintela Pousa, Ana Maria; Denoël, Thibaut; Gnesin, Silvano; Scopinaro, Francesco; Vozenin, Marie-Catherine; Prior, John O.

2017-01-01

The interest around small-animal cardiac radionuclide imaging is growing as rodent models can be manipulated to allow the simulation of human diseases. In addition to new radiopharmaceuticals testing, often researchers apply well-established probes to animal models, to follow the evolution of the target disease. This reverse translation of standard radiopharmaceuticals to rodent models is complicated by technical shortcomings and by obvious differences between human and rodent cardiac physiology. In addition, radionuclide studies involving small animals are affected by several extrinsic variables, such as the choice of anesthetic. In this paper, we review the major cardiac features that can be studied with classical single-photon and positron-emitting radiopharmaceuticals, namely, cardiac function, perfusion and metabolism, as well as the results and pitfalls of small-animal radionuclide imaging techniques. In addition, we provide a concise guide to the understanding of the most frequently used anesthetics such as ketamine/xylazine, isoflurane, and pentobarbital. We address in particular their mechanisms of action and the potential effects on radionuclide imaging. Indeed, cardiac function, perfusion, and metabolism can all be significantly affected by varying anesthetics and animal handling conditions. PMID:28424774

How leadership attributes influence employee loyalty in the aerospace industry: An exploratory qualitative inquiry

NASA Astrophysics Data System (ADS)

Harrison, Marriel

The influence leaders have on employee loyalty in the aerospace industry was examined through exploratory, qualitative inquiry. In-depth, semi-structured interviews were conducted to ascertain the influence of six leadership attributes on loyalty. These specific leadership attributes were addressed based on key themes from the scholarly leadership research and included communication, trust, accountability, understanding, compassion, and recognition. Data were analyzed to identify common themes and patterns among the 21 study participants. Based on the study findings, the majority of participants expressed that they want leaders to communicate--and to do so often and concisely. Participants also voiced that communication was a central component in resolving many of the problems associated with loyalty, such as clarity of direction or sense of inclusion in the organization. The central themes derived from the research include the following: (a) employee loyalty no longer exists when organizational leadership fails to challenge or empower employees or create an opportunity for growth, (b) effective leaders inspire employees by sharing the vision of an organization and including employees in the decision-making process, and (c) organizational culture, values, and effective leadership play an integral role in employee loyalty and long-term commitment to the organization.

[Marketing research in health service].

PubMed

Ameri, Cinzia; Fiorini, Fulvio

2015-01-01

Marketing research is the systematic and objective search for, and analysis of, information relevant to the identification and solution of any problem in the field of marketing. The key words in this definition are: systematic, objective and analysis. Marketing research seeks to set about its task in a systematic and objective fashion. This means that a detailed and carefully designed research plan is developed in which each stage of the research is specified. Such a research plan is only considered adequate if it specifies: the research problem in concise and precise terms, the information necessary to address the problem, the methods to be employed in gathering the information and the analytical techniques to be used to interpret it. Maintaining objectivity in marketing research is essential if marketing management is to have sufficient confidence in its results to be prepared to take risky decisions based upon those results. To this end, as far as possible, marketing researchers employ the scientific method. The characteristics of the scientific method are that it translates personal prejudices, notions and opinions into explicit propositions (or hypotheses). These are tested empirically. At the same time alternative explanations of the event or phenomena of interest are given equal consideration.

The importance of independent chronology in integrating records of past climate change for the 60-8 ka INTIMATE time interval

NASA Astrophysics Data System (ADS)

Brauer, Achim; Hajdas, Irka; Blockley, Simon P. E.; Bronk Ramsey, Christopher; Christl, Marcus; Ivy-Ochs, Susan; Moseley, Gina E.; Nowaczyk, Norbert N.; Rasmussen, Sune O.; Roberts, Helen M.; Spötl, Christoph; Staff, Richard A.; Svensson, Anders

2014-12-01

This paper provides a brief overview of the most common dating techniques applied in palaeoclimate and palaeoenvironmental studies including four radiometric and isotopic dating methods (radiocarbon, 230Th disequilibrium, luminescence, cosmogenic nuclides) and two incremental methods based on layer counting (ice layer, varves). For each method, concise background information about the fundamental principles and methodological approaches is provided. We concentrate on the time interval of focus for the INTIMATE (Integrating Ice core, MArine and TErrestrial records) community (60-8 ka). This dating guide addresses palaeoclimatologists who aim at interpretation of their often regional and local proxy time series in a wider spatial context and, therefore, have to rely on correlation with proxy records obtained from different archives from various regions. For this reason, we especially emphasise scientific approaches for harmonising chronologies for sophisticated and robust proxy data integration. In this respect, up-to-date age modelling techniques are presented as well as tools for linking records by age equivalence including tephrochronology, cosmogenic 10Be and palaeomagnetic variations. Finally, to avoid inadequate documentation of chronologies and assure reliable correlation of proxy time series, this paper provides recommendations for minimum standards of uncertainty and age datum reporting.

Computer applications in the search for unrelated stem cell donors.

PubMed

Müller, Carlheinz R

2002-08-01

The majority of patients which are eligible for a blood stem cell transplantation from an allogeneic donor do not have a suitable related donor so that an efficient unrelated donor search is a prerequisite for this treatment. Currently, there are over 7 million volunteer donors in the files of 50 registries in the world and in most countries the majority of transplants are performed from a foreign donor. Evidently, computer and communication technology must play a crucial role in the complex donor search process on the national and international level. This article describes the structural elements of the donor search process and discusses major systematic and technical issues to be addressed in the development and evolution of the supporting telematic systems. The theoretical considerations are complemented by a concise overview over the current state of the art which is given by describing the scope, relevance, interconnection and technical background of three major national and international computer appliances: The German Marrow Donor Information System (GERMIS) and the European Marrow Donor Information System (EMDIS) are interoperable business-to-business e-commerce systems and Bone Marrow Donors World Wide (BMDW) is the basic international donor information desk on the web.

Characterizing the nature and variability of avalanche hazard in western Canada

NASA Astrophysics Data System (ADS)

Shandro, Bret; Haegeli, Pascal

2018-04-01

The snow and avalanche climate types maritime, continental and transitional are well established and have been used extensively to characterize the general nature of avalanche hazard at a location, study inter-seasonal and large-scale spatial variabilities and provide context for the design of avalanche safety operations. While researchers and practitioners have an experience-based understanding of the avalanche hazard associated with the three climate types, no studies have described the hazard character of an avalanche climate in detail. Since the 2009/2010 winter, the consistent use of Statham et al. (2017) conceptual model of avalanche hazard in public avalanche bulletins in Canada has created a new quantitative record of avalanche hazard that offers novel opportunities for addressing this knowledge gap. We identified typical daily avalanche hazard situations using self-organizing maps (SOMs) and then calculated seasonal prevalence values of these situations. This approach produces a concise characterization that is conducive to statistical analyses, but still provides a comprehensive picture that is informative for avalanche risk management due to its link to avalanche problem types. Hazard situation prevalence values for individual seasons, elevations bands and forecast regions provide unprecedented insight into the inter-seasonal and spatial variability of avalanche hazard in western Canada.

Special report on transboundary air quality issues

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1998-12-31

The International Air Quality Board was created in 1996 to provide advice to the International Joint Commission in fulfilling an air quality alerting function requested by governments in that year. The Board undertook a review of the many issues affecting transboundary air quality along the Canada-US border. This report reflects on issues previously addressed by the Board in its reporting to the Commission. Section 1 discusses the need for Canada and the US to adopt a seamless border approach to address pollution sources and receptors in a holistic manner. Section 2 discusses nitrogen oxides as a key contaminant because ofmore » its direct impact on the ecosystem and its effects on future levels of other secondary pollutants. Section 3 outlines the deficiencies of emission inventories regarding persistent toxic substances such as mercury, which must be addressed if source-to-receptor relationships are to be established. Section 4 covers the need to develop monitoring and modelling tools to further examine pollutant transport and concentration, and the resulting human and ecological exposure. Section 5 describes issues in individual regions along the border. Section 6 is directed at the harmonization of standards, which would assist in the effective control of transboundary pollutants such as ozone. Section 7 discusses collaboration with other organizations in addressing transboundary air pollution issues. Section 8 describes various feedback mechanisms for verifying that the elimination or management of air pollution is achieving improvement and benefits. Section 9 considers emissions and preventive strategies for major source sectors, including coal-fired utilities and mobile sources. The final section outlines future Board activities.« less

40 CFR 256.04 - State plan approval, financial assistance.

Code of Federal Regulations, 2014 CFR

2014-07-01

... WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Purpose... of these guidelines which address sections 4003(1), (2), (3), and (5), and (2) It contains provisions... with all of the requirements of these guidelines, including the requirements which address sections...

40 CFR 256.04 - State plan approval, financial assistance.

Code of Federal Regulations, 2010 CFR

2010-07-01

... WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Purpose... of these guidelines which address sections 4003(1), (2), (3), and (5), and (2) It contains provisions... with all of the requirements of these guidelines, including the requirements which address sections...

40 CFR 256.04 - State plan approval, financial assistance.

Code of Federal Regulations, 2012 CFR

2012-07-01

... WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Purpose... of these guidelines which address sections 4003(1), (2), (3), and (5), and (2) It contains provisions... with all of the requirements of these guidelines, including the requirements which address sections...

40 CFR 256.04 - State plan approval, financial assistance.

Code of Federal Regulations, 2013 CFR

2013-07-01

... WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Purpose... of these guidelines which address sections 4003(1), (2), (3), and (5), and (2) It contains provisions... with all of the requirements of these guidelines, including the requirements which address sections...

40 CFR 256.04 - State plan approval, financial assistance.

Code of Federal Regulations, 2011 CFR

2011-07-01

... WASTES GUIDELINES FOR DEVELOPMENT AND IMPLEMENTATION OF STATE SOLID WASTE MANAGEMENT PLANS Purpose... of these guidelines which address sections 4003(1), (2), (3), and (5), and (2) It contains provisions... with all of the requirements of these guidelines, including the requirements which address sections...

Generating Concise Natural Language Summaries.

ERIC Educational Resources Information Center

McKeown, Kathleen; And Others

1995-01-01

Presents an approach to summarization that combines information from multiple facts into a single sentence using linguistic constructions. Describes two applications: one produces summaries of basketball games, and the other contains summaries of telephone network planning activity. Both summarize input data as opposed to full text. Discusses…

Microfiltration and Ultrafiltration Membranes for Drinking Water

EPA Science Inventory

This article provides a concise and abbreviated summary of AWWA Manual of Practice M53, Microfiltration and Ultrafiltration Membranes for Drinking Water, to serve as a quick point of reference. For convenience, the article’s organization matches that of M53, as follows: • wate...

24 CFR 91.315 - Strategic plan.

Code of Federal Regulations, 2014 CFR

2014-04-01

... concise summary of the jurisdiction's activities to enhance coordination among Continuums of Care, public... care (such as health-care facilities, mental health facilities, foster care and other youth facilities...), which must be developed in accordance with the primary objective of the CDBG program to develop viable...

24 CFR 91.315 - Strategic plan.

Code of Federal Regulations, 2013 CFR

2013-04-01

... concise summary of the jurisdiction's activities to enhance coordination among Continuums of Care, public... care (such as health-care facilities, mental health facilities, foster care and other youth facilities...), which must be developed in accordance with the primary objective of the CDBG program to develop viable...

24 CFR 91.315 - Strategic plan.

Code of Federal Regulations, 2012 CFR

2012-04-01

... concise summary of the jurisdiction's activities to enhance coordination among Continuums of Care, public... care (such as health-care facilities, mental health facilities, foster care and other youth facilities...), which must be developed in accordance with the primary objective of the CDBG program to develop viable...

Cloud Computing Explained

ERIC Educational Resources Information Center

Metz, Rosalyn

2010-01-01

While many talk about the cloud, few actually understand it. Three organizations' definitions come to the forefront when defining the cloud: Gartner, Forrester, and the National Institutes of Standards and Technology (NIST). Although both Gartner and Forrester provide definitions of cloud computing, the NIST definition is concise and uses…

Silvics of Missouri bottomland tree species

Treesearch

John Kabrick; Daniel Dey

2001-01-01

This issue of Notes For Forest Managers provides a concise summary of important silvical characteristics of Missouri's bottomland trees. It focuses on species adaptations to or tolerances of, environmental and site conditions. It is a compilation of information from seven different references cited in the text.

Training the Technical Editor.

ERIC Educational Resources Information Center

Cathcart, Margaret E.

The demand for skilled technical editors is growing as society places increasing emphasis on receiving accurate, concise, and complete technical data. Since many organizations do not have inhouse programs for training technical editors, a need exists to provide inexperienced people with basic editing skills. One organization has developed two…

Integrated Science Assessment (ISA) for Lead (Final Report, Jul 2013)

EPA Science Inventory

EPA announced the availability of the final report, Integrated Science Assessment (ISA) for Lead (Pb). This document represents a concise synthesis and evaluation of the most policy-relevant science and will ultimately provide the scientific bases for EPA’s decision regard...

Integrating Creativity into Online University Classes

ERIC Educational Resources Information Center

Muirhead, Brent

2007-01-01

In this article, the author provides a concise discussion on creativity, defining the term, sharing theoretical background information and offering insights into promoting creativity in online university classes. Emphasis will be placed on relevant ways to integrate creativity into instructional activities across the academic disciplines. He…

21 CFR 809.10 - Labeling for in vitro diagnostic products.

Code of Federal Regulations, 2010 CFR

2010-04-01

... principles of the procedure. Explain concisely, with chemical reactions and techniques involved, if...) Instruments: (i) Use or function. (ii) Installation procedures and special requirements. (iii) Principles of... product testing prior to full commercial marketing (for example, for use on specimens derived from humans...

Educational Stratification in Russia during the Soviet Period.

ERIC Educational Resources Information Center

Gerber, Theodore P.; Hout, Michael

1995-01-01

Maintains that, in spite of state efforts to reduce educational inequities, stratification actually increased during the Soviet period. Removing gender preferences for men corrected some inequity. However, parents' education, occupation, and geographical origin contributed to the stratification. Contains a concise history of Soviet educational…

Clinically relevant pharmacokinetic herb-drug interactions in antiretroviral therapy

USDA-ARS?s Scientific Manuscript database

For healthcare professionals, the volume of literature available on herb-drug interactions often makes it difficult to separate experimental/potential interactions from those deemed clinically relevant. There is a need for concise and conclusive information to guide pharmacotherapy in HIV/AIDS. In t...

Constructive Management of Conflict in Groups.

ERIC Educational Resources Information Center

Mitchell, Rex C.; Mitchell, Rie R.

1984-01-01

Provides a concise overview of important conflict management concepts and strategies for those working in group settings. Presents a brief conceptual basis for understanding conflict and group memebers' behavior when in conflict, followed by specific recommendations for managing and making use of conflict in groups. (JAC)

Types and Consequences of DNA Damage

EPA Science Inventory

This review provides a concise overview of the types of DNA damage and the molecular mechanisms by which a cell senses DNA damage, repairs the damage, converts the damage into a mutation, or dies as a consequence of unrepaired DNA damage. Such information is important in consid...

MARINE MAMMAL DISEASES: PATHOGENS AND PROCESSES

EPA Science Inventory

The purpose of this chapter is to provide a concise overview of the pathogens and processes that alter the health of marine mammals. Viral disease is the most common etiology of significant mortality events in marine mammals. Discussion of viral disease focuses on effects in the ...

DERMAL EXPOSURE ASSESSMENT: A SUMMARY OF EPA APPROACHES

EPA Science Inventory

This final report presents a concise description and evaluation of the approaches used in the Agency for dermal exposure assessment including a discussion about harmonization and research needs in this area. The report is intended to be used by EPA program offices in their effort...

17 CFR 229.402 - (Item 402) Executive compensation.

Code of Federal Regulations, 2013 CFR

2013-04-01

..., concise and understandable disclosure of all plan and non-plan compensation awarded to, earned by, or paid... stock units, phantom stock, phantom stock units, common stock equivalent units or any similar..., registrants may omit information regarding group life, health, hospitalization, or medical reimbursement plans...

17 CFR 229.402 - (Item 402) Executive compensation.

Code of Federal Regulations, 2012 CFR

2012-04-01

..., concise and understandable disclosure of all plan and non-plan compensation awarded to, earned by, or paid... stock units, phantom stock, phantom stock units, common stock equivalent units or any similar..., registrants may omit information regarding group life, health, hospitalization, or medical reimbursement plans...

17 CFR 229.402 - (Item 402) Executive compensation.

Code of Federal Regulations, 2010 CFR

2010-04-01

..., concise and understandable disclosure of all plan and non-plan compensation awarded to, earned by, or paid... stock units, phantom stock, phantom stock units, common stock equivalent units or any similar... to one person. Registrants may omit information regarding group life, health, hospitalization, or...

17 CFR 229.402 - (Item 402) Executive compensation.

Code of Federal Regulations, 2011 CFR

2011-04-01

..., concise and understandable disclosure of all plan and non-plan compensation awarded to, earned by, or paid... stock units, phantom stock, phantom stock units, common stock equivalent units or any similar... to one person. Registrants may omit information regarding group life, health, hospitalization, or...

Living English

ERIC Educational Resources Information Center

Speight, Stephen

1977-01-01

The latest (July, 1976) edition of the "Concise Oxford Dictionary" is seen as "prescriptive," and of limited use to foreigners, since it lacks an international phonetic transcription. It is questioned whether sufficient treatment is given to new words, scientific words, non-British English, obscene language, change of meaning, and obsolescence.…

Radiology of spinal curvature

DOE Office of Scientific and Technical Information (OSTI.GOV)

De Smet, A.A.

1985-01-01

This book offers the only comprehensive, concise summary of both the clinical and radiologic features of thoracic and lumbar spine deformity. Emphasis is placed on idiopathic scoliosis, which represents 85% of all patients with scoliosis, but less common areas of secondary scoliosis, kyphosis and lordosis are also covered.

China: Background Notes Series.

ERIC Educational Resources Information Center

Reams, Joanne Reppert

Concise background information on the People's Republic of China is provided. The publication begins with a profile of the country, outlining the people, geography, economy, and membership in international organizations. The bulk of the document then discusses in more detail China's people, geography, history, government, education, economy, and…

Coverage vs Frequency : Is Spatial Coverage or Temporal Frequency More Impactful on Transit Ridership?

DOT National Transportation Integrated Search

2017-08-01

Transit ridership has long been studied, and the findings are concisely elucidated by Taylor & Fink (2003) when they say To sum, transit ridership is largely, though not completely, a product of factors outside the control of transit managers. ...

Pulse!! The Virtual Clinical Learning Lab and Center of Excellence

DTIC Science & Technology

2011-08-01

environments, physiological assets and case-authoring tools using state- of-the art technologies common to the videogame industry but here appropriated...interior processes (e.g., fluid dynamics) are beyond the current reach of the videogame industry. c. Concise Accomplishments (limit 200 words/170

Why Teach Playwriting?

ERIC Educational Resources Information Center

Levy, Jonathan

2001-01-01

Ponders what students might learn from a course in playwriting: the ability to think in vivid instances and moments; the habit of close observation of the details of human behavior; the ability to think through and see through cliches; making hard choices; sympathy; dreaming within limits; and concision. (SR)

MicroSIFT Courseware Evaluations (88-168).

ERIC Educational Resources Information Center

Holznagel, Donald C., Ed.

This document consists of 81 microcomputer software package evaluations prepared for the MicroSIFT (Microcomputer Software and Information for Teachers) Clearinghouse at the Northwest Regional Educational Laboratory (NWREL) and distributed during 1983 as "sets" 6, 7, and 8. The concise, single-sheet resume describing and evaluating each…

A simple rule of direct reciprocity leads to the stable coexistence of cooperation and defection in the Prisoner's Dilemma game.

PubMed

Zheng, Xiu-Deng; Li, Cong; Yu, Jie-Ru; Wang, Shi-Chang; Fan, Song-Jia; Zhang, Bo-Yu; Tao, Yi

2017-05-07

The long-term coexistence of cooperation and defection is a common phenomenon in nature and human society. However, none of the theoretical models based on the Prisoner's Dilemma (PD) game can provide a concise theoretical model to explain what leads to the stable coexistence of cooperation and defection in the long-term even though some rules for promoting cooperation have been summarized (Nowak, 2006, Science 314, 1560-1563). Here, based on the concept of direct reciprocity, we develop an elementary model to show why stable coexistence of cooperation and defection in the PD game is possible. The basic idea behind our theoretical model is that all players in a PD game prefer a cooperator as an opponent, and our results show that considering strategies allowing opting out against defection provide a general and concise way of understanding the fundamental importance of direct reciprocity in driving the evolution of cooperation. Copyright © 2017 Elsevier Ltd. All rights reserved.

Concise Review: Fetal Membranes in Regenerative Medicine: New Tricks from an Old Dog?

PubMed Central

2017-01-01

Abstract The clinical application of the fetal membranes dates back to nearly a century. Their use has ranged from superficial skin dressings to surgical wound closure. The applications of the fetal membranes are constantly evolving, and key to this is the uncovering of multiple populations of stem and stem‐like cells, each with unique properties that can be exploited for regenerative medicine. In addition to pro‐angiogenic and immunomodulatory properties of the stem and stem‐like cells arising from the fetal membranes, the dehydrated and/or decellularized forms of the fetal membranes have been used to support the growth and function of other cells and tissues, including adipose‐derived mesenchymal stem cells. This concise review explores the biological origin of the fetal membranes, a history of their use in medicine, and recent developments in the use of fetal membranes and their derived stem and stem‐like cells in regenerative medicine. Stem Cells Translational Medicine 2017;6:1767–1776 PMID:28834402

Concise Review: Therapeutic Potential of Adipose Tissue-Derived Angiogenic Cells

PubMed Central

Brinchmann, Jan E.

2012-01-01

Inadequate blood supply to tissues is a leading cause of morbidity and mortality today. Ischemic symptoms caused by obstruction of arterioles and capillaries are currently not treatable by vessel replacement or dilatation procedures. Therapeutic angiogenesis, the treatment of tissue ischemia by promoting the proliferation of new blood vessels, has recently emerged as one of the most promising therapies. Neovascularization is most often attempted by introduction of angiogenic cells from different sources. Emerging evidence suggests that adipose tissue (AT) is an excellent reservoir of autologous cells with angiogenic potential. AT yields two cell populations of importance for neovascularization: AT-derived mesenchymal stromal cells, which likely act predominantly as pericytes, and AT-derived endothelial cells (ECs). In this concise review we discuss different physiological aspects of neovascularization, briefly present cells isolated from the blood and bone marrow with EC properties, and then discuss isolation and cell culture strategies, phenotype, functional capabilities, and possible therapeutic applications of angiogenic cells obtained from AT. PMID:23197872

Gastric precancerous diseases classification using CNN with a concise model.

PubMed

Zhang, Xu; Hu, Weiling; Chen, Fei; Liu, Jiquan; Yang, Yuanhang; Wang, Liangjing; Duan, Huilong; Si, Jianmin

2017-01-01

Gastric precancerous diseases (GPD) may deteriorate into early gastric cancer if misdiagnosed, so it is important to help doctors recognize GPD accurately and quickly. In this paper, we realize the classification of 3-class GPD, namely, polyp, erosion, and ulcer using convolutional neural networks (CNN) with a concise model called the Gastric Precancerous Disease Network (GPDNet). GPDNet introduces fire modules from SqueezeNet to reduce the model size and parameters about 10 times while improving speed for quick classification. To maintain classification accuracy with fewer parameters, we propose an innovative method called iterative reinforced learning (IRL). After training GPDNet from scratch, we apply IRL to fine-tune the parameters whose values are close to 0, and then we take the modified model as a pretrained model for the next training. The result shows that IRL can improve the accuracy about 9% after 6 iterations. The final classification accuracy of our GPDNet was 88.90%, which is promising for clinical GPD recognition.

Adapting Comparative Effectiveness Research Summaries for Delivery to Patients and Providers through a Patient Portal

PubMed Central

McDougald Scott, Amanda M.; Jackson, Gretchen Purcell; Ho, Yun-Xian; Yan, Zhou; Davison, Coda; Rosenbloom, S. Trent

2013-01-01

Despite increases in the scientific evidence for a variety of medical treatments, a gap remains in the adoption of best medical practices. This manuscript describes a process for adapting published summary guides from comparative effectiveness research to render them concise, targeted to audience, and easily actionable; and a strategy for disseminating such evidence to patients and their physicians through a web-based portal and linked electronic health record. This project adapted summary guides about oral medications for adults with type 2 diabetes to a fifth-grade literacy level and modified the resulting materials based on evaluations with the Suitability Assessment of Materials instrument. Focus groups and individual interviews with patients, diabetes providers, and health literacy experts were employed to evaluate and enhance the adapted summary guide. We present the lessons learned as general guidelines for the creation of concise, targeted, and actionable evidence and its delivery to both patients and providers through increasingly prevalent health information technologies. PMID:24551387

Surface engineering of graphitic carbon nitride polymers with cocatalysts for photocatalytic overall water splitting

PubMed Central

Zhang, Guigang; Lan, Zhi-An

2017-01-01

Graphitic carbon nitride based polymers, being metal-free, accessible, environmentally benign and sustainable, have been widely investigated for artificial photosynthesis in recent years for the photocatalytic splitting of water to produce hydrogen fuel. However, the photocatalytic stoichiometric splitting of pure water into H2 and O2 with a molecular ratio of 2 : 1 is far from easy, and is usually hindered by the huge activation energy barrier and sluggish surface redox reaction kinetics. Herein, we provide a concise overview of cocatalyst modified graphitic carbon nitride based photocatalysts, with our main focus on the modulation of the water splitting redox reaction kinetics. We believe that a timely and concise review on this promising but challenging research topic will certainly be beneficial for general readers and researchers in order to better understand the property–activity relationship towards overall water splitting, which could also trigger the development of new organic architectures for photocatalytic overall water splitting through the rational control of surface chemistry. PMID:28959425

Reynolds number scaling to predict droplet size distribution in dispersed and undispersed subsurface oil releases.

PubMed

Li, Pu; Weng, Linlu; Niu, Haibo; Robinson, Brian; King, Thomas; Conmy, Robyn; Lee, Kenneth; Liu, Lei

2016-12-15

This study was aimed at testing the applicability of modified Weber number scaling with Alaska North Slope (ANS) crude oil, and developing a Reynolds number scaling approach for oil droplet size prediction for high viscosity oils. Dispersant to oil ratio and empirical coefficients were also quantified. Finally, a two-step Rosin-Rammler scheme was introduced for the determination of droplet size distribution. This new approach appeared more advantageous in avoiding the inconsistency in interfacial tension measurements, and consequently delivered concise droplet size prediction. Calculated and observed data correlated well based on Reynolds number scaling. The relation indicated that chemical dispersant played an important role in reducing the droplet size of ANS under different seasonal conditions. The proposed Reynolds number scaling and two-step Rosin-Rammler approaches provide a concise, reliable way to predict droplet size distribution, supporting decision making in chemical dispersant application during an offshore oil spill. Copyright © 2016 Elsevier Ltd. All rights reserved.

3-D World Modeling For An Autonomous Robot

NASA Astrophysics Data System (ADS)

Goldstein, M.; Pin, F. G.; Weisbin, C. R.

1987-01-01

This paper presents a methodology for a concise representation of the 3-D world model for a mobile robot, using range data. The process starts with the segmentation of the scene into "objects" that are given a unique label, based on principles of range continuity. Then the external surface of each object is partitioned into homogeneous surface patches. Contours of surface patches in 3-D space are identified by estimating the normal and curvature associated with each pixel. The resulting surface patches are then classified as planar, convex or concave. Since the world model uses a volumetric representation for the 3-D environment, planar surfaces are represented by thin volumetric polyhedra. Spherical and cylindrical surfaces are extracted and represented by appropriate volumetric primitives. All other surfaces are represented using the boolean union of spherical volumes (as described in a separate paper by the same authors). The result is a general, concise representation of the external 3-D world, which allows for efficient and robust 3-D object recognition.

THE HUMAN BEHAVIOR RATING SCALE-BRIEF: A TOOL TO MEASURE 21ST CENTURY SKILLS OF K-12 LEARNERS.

PubMed

Woods-Groves, Suzanne

2015-06-01

Currently there is a call for brief concise measurements to appraise relevant 21st century college readiness skills in K-12 learners. This study employed K-12 teachers' ratings for over 3,000 students for an existing 91-item rating scale, the Human Behavior Rating Scale, that measured the 21st century skills of persistence, curiosity, externalizing affect, internalizing affect, and cognition. Teachers' ratings for K-12 learners were used to develop a brief, concise, and manageable 30-item tool, the Human Behavior Rating Scale-Brief. Results yielded high internal consistency coefficients and inter-item correlations. The items were not biased with regard to student sex or race, and were supported through confirmatory factor analyses. In addition, when teachers' ratings were compared with students' academic and behavioral performance data, moderate to strong relationships were revealed. This study provided an essential first step in the development of a psychometrically sound, manageable, and brief tool to appraise 21st century skills in K-12 learners.

Frontiers of Theoretical Research on Shape Memory Alloys: A General Overview

NASA Astrophysics Data System (ADS)

Chowdhury, Piyas

2018-03-01

In this concise review, general aspects of modeling shape memory alloys (SMAs) are recounted. Different approaches are discussed under four general categories, namely, (a) macro-phenomenological, (b) micromechanical, (c) molecular dynamics, and (d) first principles models. Macro-phenomenological theories, stemming from empirical formulations depicting continuum elastic, plastic, and phase transformation, are primarily of engineering interest, whereby the performance of SMA-made components is investigated. Micromechanical endeavors are generally geared towards understanding microstructural phenomena within continuum mechanics such as the accommodation of straining due to phase change as well as role of precipitates. By contrast, molecular dynamics, being a more recently emerging computational technique, concerns attributes of discrete lattice structures, and thus captures SMA deformation mechanism by means of empirically reconstructing interatomic bonding forces. Finally, ab initio theories utilize quantum mechanical framework to peek into atomistic foundation of deformation, and can pave the way for studying the role of solid-sate effects. With specific examples, this paper provides concise descriptions of each category along with their relative merits and emphases.

The Primary Care Behavioral Health (PCBH) Model: An Overview and Operational Definition.

PubMed

Reiter, Jeffrey T; Dobmeyer, Anne C; Hunter, Christopher L

2018-06-01

The Primary Care Behavioral Health (PCBH) model is a prominent approach to the integration of behavioral health services into primary care settings. Implementation of the PCBH model has grown over the past two decades, yet research and training efforts have been slowed by inconsistent terminology and lack of a concise, operationalized definition of the model and its key components. This article provides the first concise operationalized definition of the PCBH model, developed from examination of multiple published resources and consultation with nationally recognized PCBH model experts. The definition frames the model as a team-based approach to managing biopsychosocial issues that present in primary care, with the over-arching goal of improving primary care in general. The article provides a description of the key components and strategies used in the model, the rationale for those strategies, a brief comparison of this model to other integration approaches, a focused summary of PCBH model outcomes, and an overview of common challenges to implementing the model.

Serious Games: A Concise Overview on What They Are and Their Potential Applications to Healthcare.

PubMed

Giunti, Guido; Baum, Analía; Giunta, Diego; Plazzotta, Fernando; Benitez, Sonia; Gómez, Adrián; Luna, Daniel; Bernaldo de Quiros, Fernan González

2015-01-01

Younger generations are extensive users of digital devices; these technologies have always existed and have always been a part of their lives. Video games are a big part of their digital experience. User-centered design is an approach to designing systems informed by scientific knowledge of how people think, act, and coordinate to accomplish their goals. There is an emerging field of intervention research looking into using these techniques to produce video games that can be applied to healthcare. Games with the purpose of improving an individual's knowledge, skills, or attitudes in the "real" world are called "Serious Games". Before doctors and patients can consider using Serious Games as a useful solution for a health care-related problem, it is important that they first are aware of them, have a basic understanding of what they are, and what, if any, claims on their effectiveness exist. In order to bridge that gap, we have produced this concise overview to introduce physicians to the subject at hand.

Pediatric rehabilitation psychology: Rehabilitating a moving target.

PubMed

Kaufman, Jacqueline N; Lahey, Sarah; Slomine, Beth S

2017-08-01

The current special section includes manuscripts focusing on four aspects of pediatric rehabilitation psychology that are unique to this practice area. The first domain addressed is natural developmental progression in the context of a disability (i.e., habilitation). The next domain addressed in this special section is pediatric rehabilitation; pediatric rehabilitation psychology addresses the reacquisition of previously attained skills and abilities within the context of the natural developmental milieu. This special section also highlights the inherently interdisciplinary and transdisciplinary nature of pediatric rehabilitation psychology given the complex environment in which children exist. Finally, the special section includes illustrations of the crucial role pediatric rehabilitation psychologists play in facilitating transitions through major milestones, particularly from pediatrics to adulthood when living with a disability. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

A proposal of an architecture for the coordination level of intelligent machines

NASA Technical Reports Server (NTRS)

Beard, Randall; Farah, Jeff; Lima, Pedro

1993-01-01

The issue of obtaining a practical, structured, and detailed description of an architecture for the Coordination Level of Center for Intelligent Robotic Systems for Sapce Exploration (CIRSSE) Testbed Intelligent Controller is addressed. Previous theoretical and implementation works were the departure point for the discussion. The document is organized as follows: after this introductory section, section 2 summarizes the overall view of the Intelligent Machine (IM) as a control system, proposing a performance measure on which to base its design. Section 3 addresses with some detail implementation issues. An hierarchic petri-net with feedback-based learning capabilities is proposed. Finally, section 4 is an attempt to address the feedback problem. Feedback is used for two functions: error recovery and reinforcement learning of the correct translations for the petri-net transitions.

50 CFR 228.8 - Mailing address.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Mailing address. 228.8 Section 228.8 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS NOTICE AND HEARING ON SECTION 103(d) REGULATIONS § 228.8 Mailing...

The Workaholism Syndrome: An Emerging Issue in the Psychological Literature

ERIC Educational Resources Information Center

Piotrowski, Chris; Vodanovich, Stephen J.

2008-01-01

The present paper provides a concise overview of the "workaholism syndrome." This includes a discussion of workaholism from an addiction perspective, it's overall components and consequences, and a conceptual framework. Suggestions are offered for effective strategies to confront and mediate the onerous impact of workaholism.

A Second-Year Undergraduate Course in Applied Differential Equations.

ERIC Educational Resources Information Center

Fahidy, Thomas Z.

1991-01-01

Presents the framework for a chemical engineering course using ordinary differential equations to solve problems with the underlying strategy of concisely discussing the theory behind each solution technique without extensions to formal proofs. Includes typical class illustrations, student responses to this strategy, and reaction of the…

Teaching Cell Division: Basics and Recommendations.

ERIC Educational Resources Information Center

Smith, Mike U.; Kindfield, Ann C. H.

1999-01-01

Presents a concise overview of cell division that includes only the essential concepts necessary for understanding genetics and evolution. Makes recommendations based on published research and teaching experiences that can be used to judge the merits of potential activities and materials for teaching cell division. Makes suggestions regarding the…

76 FR 43726 - Solicitation for a Cooperative Agreement: Developing a Method for Conducting an Internal...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-21

... domains, such as leadership, external collaboration, management and operations, sanctions, assessment and... concise and accessible format provides an opportunity for agency leadership and management to assess... Audience: The primary audience for this product is the leadership and management of correctional...

ECO-Report - Halfway home

Treesearch

Jane Kapler Smith; Janet Sullivan; Clinton E. Carlson; L. Jack Lyon; J. Tewksbury; S. Hejl; T. Martin; Stephen F. Arno; Ward McCaughey; Cathy Stewart; Colin Hardy; J. Greg Jones; Madelyn Kempf; Leslie Weldon

1996-01-01

ECO-Report is an annual Rocky Mountain Research Station (RMRS) publication which contains a set of articles showcasing the Bitterroot Ecosystem Management Research Project (BEMRP) research projects and activities. The articles are concise, user-friendly, and designed to inform a broad range of audiences interested in ecosystem management. Articles featured in...

48 CFR 2452.242-71 - Contract management system.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., concise summary of technical progress made and the costs incurred for each task during the reporting... technical progress made for each task during the reporting period; and (B) Identifies problems, or potential... and progress reporting as described herein. (b) The contract management system shall consist of two...

Strategic Planning for Educational Reform and Improvement.

ERIC Educational Resources Information Center

D'Amico, Joseph J.

1988-01-01

Defines strategic planning, outlines its key elements and activities, and summarizes the difficulties of applying a top-down, profit-driven process to education. Explains Strategic Planning for Educational Reform and Improvement (SPERI), a set of manageable, concise procedures for top school administrators. Describes SPERI applications in an…

How To Improve Students' Writing Styles.

ERIC Educational Resources Information Center

Griffin, Beverly Norris

Instructors often criticize student writing styles in abstract, nebulous terms which further serve to alienate student writers from the concept of style. College instructors should direct students to such concise, recognized discourses on improving writing style as Strunk and White's "The Elements of Style." In these manuals, specific, effective…

A CONCISE REVIEW OF THE TOXICITY AND CARCINOGENICITY OF DIMETHYLARSINIC ACID

EPA Science Inventory

Dimethylarsinic acid (DMA) has been used as an herbicide (cacodylic acid) and is the major metabolite formed after exposure to tri- (arsenite) or pentavalent (arsenate) inorganic arsenic (iAs) via ingestion or inhalation in both humans and rodents. Once viewed simply as a detoxi...

44 CFR 10.12 - Pre-implementation actions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... integrated into the decision-making process. Because of the diversity of FEMA, it is not feasible to describe..., for integration of environmental considerations into the decision-making process. The Regional... document for the purpose of justifying the decision. Rather it is a concise document that sets forth the...

44 CFR 10.12 - Pre-implementation actions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... decision-making process. Because of the diversity of FEMA, it is not feasible to describe in this part the... shall provide further guidance, commensurate with their programs and organization, for integration of... the decision. Rather it is a concise document that sets forth the decision and describes the...

44 CFR 10.12 - Pre-implementation actions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... integrated into the decision-making process. Because of the diversity of FEMA, it is not feasible to describe..., for integration of environmental considerations into the decision-making process. The Regional... document for the purpose of justifying the decision. Rather it is a concise document that sets forth the...

44 CFR 10.12 - Pre-implementation actions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... integrated into the decision-making process. Because of the diversity of FEMA, it is not feasible to describe..., for integration of environmental considerations into the decision-making process. The Regional... document for the purpose of justifying the decision. Rather it is a concise document that sets forth the...

34 CFR 682.401 - Basic program agreement.

Code of Federal Regulations, 2010 CFR

2010-07-01

... or converting the records relating to its existing guaranty portfolio to an information or computer... that owns or controls the agency's existing information or computer system. If the agency is soliciting... must include a concise description of the agency's conversion project and the actual or estimated cost...

34 CFR 682.401 - Basic program agreement.

Code of Federal Regulations, 2011 CFR

2011-07-01

... or converting the records relating to its existing guaranty portfolio to an information or computer... that owns or controls the agency's existing information or computer system. If the agency is soliciting... must include a concise description of the agency's conversion project and the actual or estimated cost...

PHYTOREMEDIATION OF CONTAMINATED SOIL AND GROUND WATER AT HAZARDOUS WASTE SITES

EPA Science Inventory

The purpose of this issue paper is to provide a concise discussion of the processes associated with the use of phytoremediation as a cleanup or containment technique for remediation of hazardous waste sites. Introductory material on plant processes is provided. The different fo...

Reconstructing the Pupils Attitude towards Technology-Survey

ERIC Educational Resources Information Center

Ardies, Jan; De Maeyer, Sven; Gijbels, David

2013-01-01

In knowledge based economies technological literacy is gaining interest. Technological literacy correlates with attitude towards technology. When measuring technological literacy as an outcome of education, the attitudinal dimension has to be taken into account. This requires a valid, reliable instrument that should be as concise as possible, in…

49 CFR 802.14 - Review procedure and judicial review.

Code of Federal Regulations, 2010 CFR

2010-10-01

... concise statement enumerating the reasons for the requester's disagreement with the denial, pursuant to...) Statements of Disagreement. (1) Written Statements of Disagreement may be furnished by the individual within... envelope, “Privacy Act Statement of Disagreement.” (2) The Director, Bureau of Administration, or his...

BIOLOGICAL EFFECTS AND DOSIMETRY OF STATIC AND ELF (EXTREMELY LOW FREQUENCY) ELECTROMAGNETIC FIELDS

EPA Science Inventory

The book offers a good introduction to the research field for students, as well as a valuable overall review for the experienced investigator. The six chapters on interactions provide concise descriptions of physical processes for natural and man-made environmental exposures and ...

A Brief History.

ERIC Educational Resources Information Center

Yalouris, Nicolaos

1996-01-01

Provides a brief but concise overview of the historical development of the Olympic Games in ancient Greece. Originally conceived as a one day, single-race event, the Games grew to the point where they represented an apotheosis of Greek culture. Discusses the role played by conflict within the city-states. (MJP)

Sudden Fiction: What Is It?

ERIC Educational Resources Information Center

Tindall, James

Initially an assignment for a library science class, this paper presents various definitions of the current creative writing phenomenon called "sudden fiction" (very short short stories with concise character sketches, and terse tales limited in length to several pages). The paper includes: (1) a list of well regarded sudden fiction…

Labor Comes into Its Own.

ERIC Educational Resources Information Center

Wehrle, Edmund F.

1996-01-01

Presents a concise and interesting overview of the rise and extension of labor activity during the New Deal. Labor took advantage of Roosevelt's pro-union policies to consolidate their power and forever transform the lives of working men and women. Discusses improvements in working conditions, wages, and benefits. (MJP)

Handbook of noise ratings

NASA Technical Reports Server (NTRS)

Pearsons, K. S.; Bennett, R. L.

1974-01-01

The handbook was compiled to provide information in a concise form, describing the multitude of noise rating schemes. It is hoped that by describing the noise rating methods in a single volume the user will have better access to the definitions, application and calculation procedures of the current noise rating methods.

The Y2K problem and management strategies for the individual practitioner.

PubMed

Alex, J C; Jassin, B M

1999-01-01

This article will detail concisely the nature of the Y2K problem, how it could affect your computer systems and your business, and what measures you can institute to minimize and/or eliminate computer failure as you enter the year 2000.

Multicultural Issues in Child Care.

ERIC Educational Resources Information Center

Gonzalez-Mena, Janet

This volume focuses on cultural differences relevant to all child-care-giving settings, including day care, nursery, and preschool programs. Based on respect for cultural pluralism, this concise supplementary text is designed to increase caregiver sensitivity to different cultural child-care practices and values and to improve communication and…

The Systems Approach: Its Variety of Aspects.

ERIC Educational Resources Information Center

Mattessich, Richard

1982-01-01

This concise survey of the vast literature currently available in field-of-systems thinking and cybernetics discusses the areas of systems philosophy, systems analysis (mathematical systems theory), empirical systems research, and systems engineering, and outlines contributions of selected scholars. A bibliography of 148 books and papers is…

Effective Literacy Instruction for Students with Moderate or Severe Disabilities

ERIC Educational Resources Information Center

Copeland, Susan R.; Keefe, Elizabeth B.

2007-01-01

For students with moderate or severe disabilities, developing literacy skills is a critical component of successful communication, employment, and community participation. Finally, educators have a practical, concise guidebook for helping these students meet NCLB's academic standards for literacy. Appropriate for use in all settings, including…

Linking Multilingual Advertising to Foreign Language Teaching.

ERIC Educational Resources Information Center

Martin, Elizabeth

It is suggested that print advertising is particularly well suited to classroom second language teaching because it is attractive, entertaining, contains powerful emotional or factual messages, and is concise. Research indicates that multilingual or code-mixed advertising is common and reveals interesting linguistic phenomena, including semantic,…

21 CFR 101.13 - Nutrient content claims-general principles.

Code of Federal Regulations, 2014 CFR

2014-04-01

... must also bear: (A) Clear and concise quantitative information comparing the amount of the subject... is on the information panel, the quantitative information may be located elsewhere on the information...., “Modified fat cheesecake”). This statement of identity must be immediately followed by the comparative...

21 CFR 101.13 - Nutrient content claims-general principles.

Code of Federal Regulations, 2011 CFR

2011-04-01

... must also bear: (A) Clear and concise quantitative information comparing the amount of the subject... is on the information panel, the quantitative information may be located elsewhere on the information...., “Modified fat cheesecake”). This statement of identity must be immediately followed by the comparative...

21 CFR 101.13 - Nutrient content claims-general principles.

Code of Federal Regulations, 2010 CFR

2010-04-01

... must also bear: (A) Clear and concise quantitative information comparing the amount of the subject... is on the information panel, the quantitative information may be located elsewhere on the information...., “Modified fat cheesecake”). This statement of identity must be immediately followed by the comparative...

21 CFR 101.13 - Nutrient content claims-general principles.

Code of Federal Regulations, 2012 CFR

2012-04-01

... must also bear: (A) Clear and concise quantitative information comparing the amount of the subject... is on the information panel, the quantitative information may be located elsewhere on the information...., “Modified fat cheesecake”). This statement of identity must be immediately followed by the comparative...

21 CFR 101.13 - Nutrient content claims-general principles.

Code of Federal Regulations, 2013 CFR

2013-04-01

... must also bear: (A) Clear and concise quantitative information comparing the amount of the subject... is on the information panel, the quantitative information may be located elsewhere on the information...., “Modified fat cheesecake”). This statement of identity must be immediately followed by the comparative...

The Community College Story. Third Edition

ERIC Educational Resources Information Center

Vaughan, George B.

2006-01-01

This concise history of community colleges touches on major themes, including open access and equity, comprehensiveness, community-based philosophy, commitment to teaching, and lifelong learning. The third edition includes revised text as well as updated statistical information, time line, reading list, and Internet resources. In the more than a…

Vocabulary Instruction: Research to Practice. Second Edition

ERIC Educational Resources Information Center

Kame'enui, Edward J., Ed.; Baumann, James F., Ed.

2012-01-01

This highly regarded work brings together prominent authorities on vocabulary teaching and learning to provide a comprehensive yet concise guide to effective instruction. The book showcases practical ways to teach specific vocabulary words and word-learning strategies and create engaging, word-rich classrooms. Instructional activities and games…

29 CFR 458.55 - Content of complaint.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Prohibited Discipline § 458.55 Content of complaint. (a) The complaint shall contain appropriate identifying information and a clear and concise statement of the facts constituting the alleged violation. (b) The complainant shall submit with his complaint a statement setting forth the procedures, if any, invoked to...