Frequency of alleles conferring resistance to a Bacillus thuringiensis toxin in a Philippine population of Scirpophaga incertulas (Lepidoptera: Pyralidae).

PubMed

Bentur, J S; Andow, D A; Cohen, M B; Romena, A M; Gould, F

2000-10-01

Using the F2 screen methodology, we estimated the frequency of alleles conferring resistance to the Cry1Ab toxin of Bacillus thuringiensis Berliner in a Philippine population of the stem borer Scirpophaga incertulas (Walker). Evaluation of >450 isofemale lines for survival of F2 larvae on cry1Ab plants did not detect the presence of an allele conferring a high level of resistance. The frequency of such an allele in the sampled population was conservatively estimated to be <3.6 x 10(-3) with 95% confidence and a detection probability of 94%. However, there was evidence of the presence of alleles conferring partial resistance to Cry1Ab. The frequency of alleles for partial resistance was estimated as 4.8 x 10(-3) with a 95% CI between 1.3 x 10(-3) and 1.04 x 10(-2) and a detection probability of 94%. Our results suggest that the frequency of alleles conferring resistance to Cry1Ab in the population of S. incertulas sampled is not too high to preclude successful implementation of the high dose/refuge resistance management strategy.

Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1 maturation inhibitor bevirimat.

PubMed

Adamson, Catherine S; Sakalian, Michael; Salzwedel, Karl; Freed, Eric O

2010-04-20

The maturation inhibitor bevirimat (BVM) potently inhibits human immunodeficiency virus type 1 (HIV-1) replication by blocking capsid-spacer peptide 1 (CA-SP1) cleavage. Recent clinical trials demonstrated that a significant proportion of HIV-1-infected patients do not respond to BVM. A patient's failure to respond correlated with baseline polymorphisms at SP1 residues 6-8. In this study, we demonstrate that varying levels of BVM resistance are associated with point mutations at these residues. BVM susceptibility was maintained by SP1-Q6A, -Q6H and -T8A mutations. However, an SP1-V7A mutation conferred high-level BVM resistance, and SP1-V7M and T8Delta mutations conferred intermediate levels of BVM resistance. Future exploitation of the CA-SP1 cleavage site as an antiretroviral drug target will need to overcome the baseline variability in the SP1 region of Gag.

Accumulation of multiple mutations in linezolid-resistant Staphylococcus epidermidis causing bloodstream infections; in silico analysis of L3 amino acid substitutions that might confer high-level linezolid resistance.

PubMed

Ikonomidis, Alexandros; Grapsa, Anastasia; Pavlioglou, Charikleia; Demiri, Antonia; Batarli, Alexandra; Panopoulou, Maria

2016-12-01

Fifty-six Staphylococcus epidermidis clinical isolates, showing high-level linezolid resistance and causing bacteremia in critically ill patients, were studied. All isolates belonged to ST22 clone and carried the T2504A and C2534T mutations in gene coding for 23SrRNA as well as the C189A, G208A, C209T and G384C missense mutations in L3 protein which resulted in Asp159Tyr, Gly152Asp and Leu94Val substitutions. Other silent mutations were also detected in genes coding for ribosomal proteins L3 and L22. In silico analysis of missense mutations showed that although L3 protein retained the sequence of secondary motifs, the tertiary structure was influenced. The observed alteration in L3 protein folding provides an indication on the putative role of L3-coding gene mutations in high-level linezolid resistance. Furthermore, linezolid pressure in health care settings where linezolid consumption is of high rates might lead to the selection of resistant mutants possessing L3 mutations that might confer high-level linezolid resistance.

Renewable Electricity Futures (Presentation)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hand, M. M.

2012-08-01

This presentation library summarizes findings of NREL's Renewable Electricity Futures study, published in June 2012. RE Futures investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. It was presented to the 2012 Western Conference of Public Service Commissioners, during their June, 2012, meeting. The Western Conference of Public Service Commissioners is a regional association within the National Association of Regulatory Utility Commissioners (NARUC).

2014 International Conference on Science & Engineering in Mathematics, Chemistry and Physics (ScieTech 2014)

NASA Astrophysics Data System (ADS)

2014-04-01

2014 International Conference on Science & Engineering in Mathematics, Chemistry and Physics (ScieTech 2014), was held at the Media Hotel, Jakarta, Indonesia, on 13-14 January 2014. The ScieTech 2014 conference is aimed to bring together researchers, engineers and scientists in the domain of interest from around the world. ScieTech 2014 is placed on promoting interaction between the theoretical, experimental, and applied communities, so that a high level exchange is achieved in new and emerging areas within Mathematics, Chemistry and Physics. We would like to express our sincere gratitude to all in the Technical Program Committee who have reviewed the papers and developed a very interesting Conference Program as well as the invited and plenary speakers. This year, we received 187 papers and after rigorous review, 50 papers were accepted. The participants come from 16 countries. There are 5 (Five) Paralell Sessions and Four Keynote Speakers. It is an honour to present this volume of Journal of Physics: Conference Series (JPCS) and we deeply thank the authors for their enthusiastic and high-grade contributions. Finally, we would like to thank the conference chairmen, the members of the steering committee, the organizing committee, the organizing secretariat and the financial support from the conference sponsors that allowed the success of ScieTech 2014. The Editors of the Scietech 2014 Proceedings: Dr. Ford Lumban Gaol Dr. Benfano Soewito Dr. P.N. Gajjar

Mortality predictors in a 60-year follow-up of adolescent males: exploring delinquency, socioeconomic status, IQ, high-school drop-out status, and personality.

PubMed

Trumbetta, Susan L; Seltzer, Benjamin K; Gottesman, Irving I; McIntyre, Kathleen M

2010-01-01

To examine whether socioeconomic status (SES), high school (HS) completion, IQ, and personality traits that predict delinquency in adolescence also could explain men's delinquency-related (Dq-r) mortality risk across the life span. Through a 60-year Social Security Death Index (SSDI) follow-up of 1812 men from Hathaway's adolescent normative Minnesota Multiphasic Personality Inventory (MMPI) sample, we examined mortality risk at various ages and at various levels of prior delinquency severity. We examined SES (using family rent level), HS completion, IQ, and MMPI indicators simultaneously as mortality predictors and tested for SES (rent level) interactions with IQ and personality. We ascertained 418 decedents. Dq-r mortality peaked between ages 45 years to 64 years and continued through age 75 years, with high delinquency severity showing earlier and higher mortality risk. IQ and rent level failed to explain Dq-r mortality. HS completion robustly conferred mortality protection through ages 55 years and 75 years, explained IQ and rent level-related risk, but did not fully explain Dq-r risk. Dq-r MMPI scales, Psychopathic Deviate, and Social Introversion, respectively, predicted risk for and protection from mortality by age 75 years, explaining mortality risk otherwise attributable to delinquency. Wiggins' scales also explained Dq-r mortality risk, as Authority Conflict conferred risk for and Social Maladjustment and Hypomania conferred protection from mortality by age 75 years. HS completion robustly predicts mortality by ages 55 years and 75 years. Dq-r personality traits predict mortality by age 75 years, accounting, in part, for Dq-r mortality.

3rd International Conference on Energy Equipment Science and Engineering (ICEESE 2017)

NASA Astrophysics Data System (ADS)

2018-03-01

PREFACE On behalf of the organizing committee of the 2017 3rd International Conference on Energy Equipment Science and Engineering (ICEESE 2017), I would like to express a warm “Thank You” to all the participants, for their important contribution they brought to the Conference! I strongly appreciate the contribution of the authors, who submitted valuable papers and agreed to do successive revisions of their papers, following the recommendations received from the reviewers. ICEESE 2017 was held in Beijing, China during December28-31, 2017, which was organized by Wuhan University and Guizhou Minzu University. The conference provides a useful and wide platform both for display the latest research and for exchange of research results and thoughts in Energy Equipment Science and Engineering. The participants of the conference were from almost every part of the world, with background of either academia or industry, even well-known enterprise. The success and prosperity of the conference is reflected high level of the papers received. List of Committees available in this pdf.

Status of trauma quality improvement programs in the Americas: a survey of trauma care providers.

PubMed

Zetlen, Hilary L; LaGrone, Lacey N; Foianini, Jorge Esteban; Egoavil, Eduardo Huaman; Sproviero, Jorge; Rivera, Felipe Vega; Mock, Charles N

2017-12-01

Global disparities in trauma care contribute to significant morbidity and mortality (M&M) in low- and middle-income countries. Implementation of quality improvement (QI) programs has been shown to be a cost-effective strategy to improve trauma care quality. In this study, we aim to characterize the trauma QI programs in a broad range of low- to high-income countries in the Americas to assess areas for targeted improvement in global trauma QI efforts. We conducted a mixed methods survey of trauma care providers in North and South America distributed in-person at trauma care conferences and online via a secure survey platform. Responses were analyzed to observe differences across respondent country income categories. One hundred ninety-two surveys were collected, representing 21 different countries from three income strata (three lower-middle-, eleven upper-middle-, and eight high-income countries). Respondents were primarily physicians or physicians-in-training (85%). Eighty-nine percent of respondents worked at an institution where M&M conferences occurred. M&M conferences were significantly more frequent at higher income levels (P = 0.002), as was attending physician presence at M&M conferences (70% in high-income countries versus 43% in lower-middle-income countries). There were also significant differences in the structure, quality, and follow-up of M&M conferences in lower versus higher income countries. Sixty-three percent of respondents reported observing some kind of positive change at their institution due to M&M conferences. The survey also suggested significantly higher utilization of autopsy (P < 0.001) and electronic trauma registries (P = 0.01) at higher income levels. This survey demonstrated an encouraging pattern of widespread adoption of trauma QI programs in several countries in North and South America. However, there continue to be significant disparities in the structure and function of trauma QI efforts in low- and middle-income countries in the Americas. There are several potential areas for development and improvement of trauma care systems, including standardization of case selection and follow-up for M&M conferences and increased use of medical literature to improve evidence-based care. Copyright © 2017 Elsevier Inc. All rights reserved.

The use of a Mentoring-Based Conference as a Research Career Stimulation Strategy

PubMed Central

Interian, Alejandro; Escobar, Javier I.

2009-01-01

Introduction Across healthcare, US minority populations including Latinos face disparities in risk for disease, clinical outcomes, and quality of care. The discourse related to disparity problems has often highlighted the need to increase the number of minority scientists so that the productivity of research focusing on minority populations is expanded. As a result, a group of Latino mental health researchers collaborated to develop a national network of senior mentors that participated in annual mentoring-oriented conferences. A cost-effective program was developed to stimulate the entry of new investigators into the field and provide mentoring with a focus on Latino mental health issues. Method A conference-platform was used as the career stimulation strategy. Annual conferences were held (2002 – 2006) that emphasized the showcasing of new investigators' work, pairing new investigators with senior researchers, and a feedback-oriented environment. Quantitative data were used to track new investigator career progress (i.e., publications, research grants), while qualitative data were used to assess all attendees' feedback, which was provided via conference feedback questionnaires. Results The feedback questionnaires revealed high levels of satisfaction with the conference, noting most highly the interactive, friendly, and nurturing conference format. Career tracking data indicated that nearly half of the new investigators participants published their work in peer-reviewed journals, and that about one-third of were successful in obtaining research funding. Conclusions These mentoring conferences appear to be an effective tool for stimulating the research careers of new investigators engaged in Latino mental health research. PMID:19881428

Patient-reported disease knowledge and educational needs in Lynch syndrome: findings of an interactive multidisciplinary patient conference

PubMed Central

2014-01-01

Background Patients with Lynch Syndrome, the most common hereditary colorectal cancer syndrome, benefit from genetic education and family counseling regarding diagnostic testing and cancer surveillance/prevention recommendations. Although genetic counseling is currently the most common venue where such education and counseling takes place, little is known about the level of disease knowledge and education needs as directly reported by patients and families with Lynch Syndrome. Furthermore, experiences with forums for larger-scale knowledge transfer have been limited in the current literature. Methods We conducted a one-day interactive multidisciplinary patient conference, designed to complement individual genetic counseling for updating disease knowledge, supportive networking and needs assessment among Lynch Syndrome patients and their family members. The patient conference was designed utilizing the conceptual framework of action research. Paired pre- and post-conference surveys were administered to 44 conference participants anonymously to assess patient-reported disease knowledge and education needs. Results A multidisciplinary team of expert providers utilized a variety of educational formats during the one-day conference. Four main focus areas were: genetic testing, surveillance/prevention, living with Lynch Syndrome, and update on research. Thirty-two participants (73%) completed the pre-conference, and 28 (64%) participants completed the post-conference surveys. Nineteen respondents were affected and the remaining were unaffected. The scores of the disease-knowledge items significantly increased from 84% pre- to 92% post-conference (p = 0.012). Patients reported a high level of satisfaction and identified further knowledge needs in nutrition (71%), surveillance/prevention options (71%), support groups (36%), cancer risk assessment (32%), active role in medical care (32%), and research opportunities (5%). Conclusion Our experience with a dedicated patient education conference focused on Lynch Syndrome demonstrated that such an educational format is effective for updating or reinforcing disease knowledge, for identifying patient-reported unmet educational needs, as well as for peer-support. PMID:24499499

Patient-reported disease knowledge and educational needs in Lynch syndrome: findings of an interactive multidisciplinary patient conference.

PubMed

Bannon, Sarah A; Mork, Maureen; Vilar, Eduardo; Peterson, Susan K; Lu, Karen; Lynch, Patrick M; Rodriguez-Bigas, Miguel A; You, Yiqian Nancy

2014-02-05

Patients with Lynch Syndrome, the most common hereditary colorectal cancer syndrome, benefit from genetic education and family counseling regarding diagnostic testing and cancer surveillance/prevention recommendations. Although genetic counseling is currently the most common venue where such education and counseling takes place, little is known about the level of disease knowledge and education needs as directly reported by patients and families with Lynch Syndrome. Furthermore, experiences with forums for larger-scale knowledge transfer have been limited in the current literature. We conducted a one-day interactive multidisciplinary patient conference, designed to complement individual genetic counseling for updating disease knowledge, supportive networking and needs assessment among Lynch Syndrome patients and their family members. The patient conference was designed utilizing the conceptual framework of action research. Paired pre- and post-conference surveys were administered to 44 conference participants anonymously to assess patient-reported disease knowledge and education needs. A multidisciplinary team of expert providers utilized a variety of educational formats during the one-day conference. Four main focus areas were: genetic testing, surveillance/prevention, living with Lynch Syndrome, and update on research. Thirty-two participants (73%) completed the pre-conference, and 28 (64%) participants completed the post-conference surveys. Nineteen respondents were affected and the remaining were unaffected. The scores of the disease-knowledge items significantly increased from 84% pre- to 92% post-conference (p = 0.012). Patients reported a high level of satisfaction and identified further knowledge needs in nutrition (71%), surveillance/prevention options (71%), support groups (36%), cancer risk assessment (32%), active role in medical care (32%), and research opportunities (5%). Our experience with a dedicated patient education conference focused on Lynch Syndrome demonstrated that such an educational format is effective for updating or reinforcing disease knowledge, for identifying patient-reported unmet educational needs, as well as for peer-support.

PREFACE: 2013 International Conference on Manufacturing, Optimization, Industrial and Material Engineering (MOIME 2013)

NASA Astrophysics Data System (ADS)

Lumban Gaol, Ford; Rizwan Hussain, Raja; Pandiangan, Tumpal; Desai, Amit

2013-06-01

Banner The 2013 International Conference on Manufacturing, Optimization, Industrial and Material Engineering (MOIME 2013), was held at the Grand Royal Panghegar Hotel, Bandung, Indonesia, from 9-10 March 2013. The MOIME 2013 conference brought together researchers, engineers and scientists in the field from around the world. MOIME 2013 aimed to promote interaction between the theoretical, experimental, and applied communities, so that a high level exchange was achieved in new and emerging areas within Material Engineering, Industrial Engineering and all areas that related to Optimization. We would like to express our sincere gratitude to all in the Technical Program Committee who reviewed the papers and developed a very interesting Conference Program as well as the invited and plenary speakers. This year, we received 103 papers and after rigorous review, 45 papers were accepted. The participants came from 16 countries. There were six Plenary and Invited Speakers. It is an honour to present this volume of IOP Conference Series: Materials Science and Engineering (MSE) and we deeply thank the authors for their enthusiastic and high-grade contribution. Finally, we would like to thank the conference chairmen, the members of the steering committee, the organizing committee, the organizing secretariat and the conference sponsors for the financial support that contributed to the success of MOIME 2013. The Editors of the MOIME 2013 Dr Ford Lumban Gaol Dr Raja Rizwan Hussain Tumpal Pandiangan Dr Amit Desai The PDF contains the abstracts from the plenary and invited articles and the workshop.

2014 International Conference on Manufacturing, Optimization, Industrial and Material Engineering

NASA Astrophysics Data System (ADS)

Lumban Gaol, Ford; Webb, Jeff; Ding, Jun

2014-06-01

The 2nd International Conference on Manufacturing, Optimization, Industrial and Material Engineering 2014 (MOIME 2014), was held at the Grand Mercure Harmoni, Opal Room 3rd Floor, Jakarta, Indonesia, during 29-30 March 2014. The MOIME 2014 conference is designed to bring together researchers, engineers and scientists in the domain of interest from around the world. MOIME 2014 is placed on promoting interaction between the theoretical, experimental, and applied communities, so that a high level exchange is achieved in new and emerging areas within Material Engineering, Industrial Engineering and all areas that relate to Optimization. We would like to express our sincere gratitude to all in the Technical Program Committee who have reviewed the papers and developed a very interesting Conference Program as well as the invited and plenary speakers. This year, we received 97 papers and after rigorous review, 24 papers were accepted. The participants come from 7 countries. There are 4 (four) parallel session and 2 Invited Speakers and one workshop. It is an honour to present this volume of IOP Conference Series: Materials Science and Engineering (MSE) and we deeply thank the authors for their enthusiastic and high-grade contributions. Finally, we would like to thank the conference chairmen, the members of the steering committee, the organizing committee, the organizing secretariat and the financial support from the conference sponsors that allowed the success of MOIME 2014. The Editors of the MOIME 2014 Proceedings Editors Dr Ford Lumban Gaol Jeff Webb, PhD Professor Jun Ding, PhD

PREFACE: 3rd International Conference on Manufacturing, Optimization, Industrial and Material Engineering (MOIME 2015)

NASA Astrophysics Data System (ADS)

Lumban Gaol, Ford; Webb, Jeff; Ding, Jun

2015-05-01

The 3rd International Conference on Manufacturing, Optimization, Industrial and Material Engineering (MOIME 2015) was held at the Sheraton Kuta, Bali, Indonesia, from 28 - 29 March 2015. The MOIME 2015 conference is aimed to bring together researchers, engineers and scientists in the domain of interest from around the world. MOIME 2015 is placed on promoting interaction between the theoretical, experimental, and applied communities, so that a high level exchange is achieved in new and emerging areas within Material Engineering, Industrial Engineering and all areas that relate to Optimization. We would like to express our sincere gratitude to all in the Technical Program Committee who have reviewed the papers and developed a very interesting Conference Program, as well as the invited and plenary speakers. This year, we received 99 papers and after rigorous review, 24 papers were accepted. The participants come from eight countries. There were four parallel sessions and two invited speakers. It is an honour to present this volume of IOP Conference Series: Materials Science and Engineering (MSE) and we deeply thank the authors for their enthusiastic and high-grade contributions. Finally, we would like to thank the conference chairmen, the members of the steering committee, the organizing committee, the organizing secretariat and the financial support from the conference sponsors that allowed the success of MOIME 2015. The Editors of the MOIME 2015 Proceedings Dr. Ford Lumban Gaol Jeff Webb, Ph.D Prof. Jun DING, Ph.D

Face-Threatening Acts and Politeness Theory: Contrasting Speeches from Supervisory Conferences.

ERIC Educational Resources Information Center

Roberts, Jo

Discourse analysis describes a level of spoken text that lies between grammar and nonlinguistic organization. Using such an approach to understand the practical problems of communication in supervisory conferences, this paper explores two dimensions of the conference: risk and politeness levels. Level of risk is determined by the degrees of…

Improving the Spiritual Dimension of Whole Person Care: Reaching National and International Consensus

PubMed Central

Vitillo, Robert; Hull, Sharon K.; Reller, Nancy

2014-01-01

Abstract Two conferences, Creating More Compassionate Systems of Care (November 2012) and On Improving the Spiritual Dimension of Whole Person Care: The Transformational Role of Compassion, Love and Forgiveness in Health Care (January 2013), were convened with the goals of reaching consensus on approaches to the integration of spirituality into health care structures at all levels and development of strategies to create more compassionate systems of care. The conferences built on the work of a 2009 consensus conference, Improving the Quality of Spiritual Care as a Dimension of Palliative Care. Conference organizers in 2012 and 2013 aimed to identify consensus-derived care standards and recommendations for implementing them by building and expanding on the 2009 conference model of interprofessional spiritual care and its recommendations for palliative care. The 2013 conference built on the 2012 conference to produce a set of standards and recommended strategies for integrating spiritual care across the entire health care continuum, not just palliative care. Deliberations were based on evidence that spiritual care is a fundamental component of high-quality compassionate health care and it is most effective when it is recognized and reflected in the attitudes and actions of both patients and health care providers. PMID:24842136

Combination of all-stage and high-temperature adult-plant resistance QTL confers high-level, durable resistance to stripe rust in winter wheat cultivar Madsen.

PubMed

Liu, L; Wang, M N; Feng, J Y; See, D R; Chao, S M; Chen, X M

2018-05-24

Wheat cultivar Madsen has a new gene on the short arm of chromosome 1A and two QTL for all-stage resistance and three QTL for high-temperature adult-plant resistance that in combination confer high-level, durable resistance to stripe rust. Wheat cultivar Madsen has maintained a high-level resistance to stripe rust over 30 years. To map quantitative trait loci (QTL) underlying the high-level, durable resistance, 156 recombinant inbred lines (RILs) developed from cross Avocet S × Madsen were phenotyped with selected races of Puccinia striiformis f. sp. tritici in the greenhouse seedling tests, and in naturally infected fields during 2015-2017. The RILs were genotyped by SSR and SNP markers from genotyping by sequencing and the 90 K wheat SNP chip. Three QTL for all-stage resistance were mapped on chromosomes 1AS, 1BS and 2AS, and two QTL for high-temperature adult-plant (HTAP) resistance were mapped on 3BS and 6BS. The most effective QTL on 2AS, explaining 8.97-23.10% of the phenotypic variation in seedling tests and 8.60-71.23% in field tests, contained Yr17 for all-stage resistance and an additional gene for HTAP resistance. The 6BS QTL, detected in all field tests, was identified as Yr78. The 1AS QTL, conferring all-stage resistance, was identified as a new gene, which explained 20.45 and 30.23% of variation in resistance to races PSTv-37 and PSTv-40, respectively, and contributed significantly to field resistance at Pullman in 2015-2017, but was not detected at Mount Vernon. The interactions among QTL were mostly additive, and RILs with all five QTL had the highest level of resistance in the field, similar to Madsen. Genotyping 148 US Pacific Northwest wheat cultivars with markers for the 1AS, 2AS and 6BS QTL validated the genes and markers, and indicated their usefulness for marker-assisted selection.

PREFACE: 2013 International Conferences on Geological, Geographical, Aerospace and Earth Sciences (AeroEarth 2013)

NASA Astrophysics Data System (ADS)

2014-03-01

The 2013 International Conferences on Geological, Geographical, Aerospace and Earth Sciences (AeroEarth 2013), was held at the Swiss Bell Mangga Besar, Jakarta, Indonesia, on 23 December 2013. The AeroEarth conference aims to bring together researchers, engineers and scientists in the domain of interest from around the world. AeroEarth 2013 promotes interaction between the theoretical, experimental, and applied communities, so that high-level exchange is achieved in new and emerging areas within Earth Science. Through research and development, earth scientists have the power to preserve the planet's different resource domains by providing expert opinion and information about the forces which make life possible on Earth. We would like to express our sincere gratitude to all in the Technical Program Committee who have reviewed the papers and developed a very interesting Conference Program as well as the invited and plenary speakers. This year, we received 91 papers and after rigorous review, 17 papers were accepted. The participants come from 8 countries. There are 3 (three) Plenary Sessions and two invited Speakers. It is an honour to present this volume of IOP Conference Series: Earth and Environmental Science (EES) and we deeply thank the authors for their enthusiastic and high-grade contribution. Finally, we would like to thank the conference chairmen, the members of the steering committee, the organizing committee, the organizing secretariat and the financial support from the conference sponsors that allowed the success of AeroEarth 2013. The AeroEarth 2013 Proceedings Editors Dr. Ford Lumban Gaol Dr. Benfano Soewito Dr. Amit Desai Further information on the invited plenary speakers and photographs from the conference can be found in the pdf.

Vancouver AIDS conference: special report. The role of the military: to protect society -- and themselves.

PubMed

Whiteside, A; Winsbury, R

1996-01-01

Military personnel are at particularly high risk of becoming infected with HIV because they are in the age group at highest risk for infection, age 15-24 years; they are away from home for long periods of time; many feel invulnerable and ready to take risks; there are usually prostitutes and drugs in military areas; and troops have cash, but maybe not condoms, in their pockets. The level of attention given to HIV/AIDS in the military has grown over the course of the last few international AIDS conferences. One roundtable on HIV/AIDS in the armed forces was held at the 11th International Conference on AIDS held in Vancouver during July 7-12, 1996. A large-scale survey reported at the conference found the level of sexual activity to be significantly higher among US military personnel than in the civilian population. Even the oldest soldiers reported higher levels of multiple partner sex habits than the most sexually active young men in the UK and France. The data further indicate that significant numbers of those men who were infected continued to knowingly have unprotected sex. Data from Angola, Cambodia, Cameroon, the Central African Republic, Congo, Cote d'Ivoire, Thailand, and Zimbabwe show significantly higher levels of HIV infection among military personnel compared to the civilian populations. The authors stress the important role the military can play in preventing the spread of HIV and the need to involve military personnel in AIDS prevention programs.

CONFERENCE NOTE: Conference on Precision Electromagnetic Measurements

NASA Astrophysics Data System (ADS)

1991-01-01

The next Conference on Precision Electromagnetic Measurements (CPEM), will be held from 9 to 12 June 1992 at the Centre des Nouvelles Industries et Technologies (CNIT), La Défense, Paris, France. This conference, which is held every two years and whose importance and high level, confirmed by thirty years' experience, are recognized throughout the world, can be considered as a forum in which scientists, metrologists and professionals will have the opportunity to present and compare their research results on fundamental constants, standards and new techniques of precision measurement in the electromagnetic domain. Topics The following topics are regarded as the most appropriate for this conference: realization of units and fundamental constants d.c. a.c. and high voltage time and frequency radio-frequency and microwaves dielectrics, antennas, fields lasers, fibre optics advanced instrumentation, cryoelectronics. There will also be a session on international cooperation. Conference Language The conference language will be English. No translation will be provided. Organizers Société des Electriciens et des Electroniciens (SEE). Bureau National de Métrologie (BNM) Sponsors Institute of Electrical and Electronics Engineers (IEEE) Instrumentation & Measurement Society Union Radio Scientifique Internationale United States National Institute of Standards and Technology Centre National d'Etudes des Télécommunications Mouvement Français pour la Qualité, Section Métrologie Comité National Français de Radioélectricité Scientifique Contact Jean Zara, CPEM 92 publicity, Bureau National de Métrologie, 22, rue Monge, 75005 Paris Tel.: (33) 1 46 34 48 16, Fax: (33) 1 46 34 48 63

Functional Characterization of Bacteria Isolated from Ancient Arctic Soil Exposes Diverse Resistance Mechanisms to Modern Antibiotics

PubMed Central

Perron, Gabriel G.; Whyte, Lyle; Turnbaugh, Peter J.; Goordial, Jacqueline; Hanage, William P.; Dantas, Gautam; Desai, Michael M.

2015-01-01

Using functional metagenomics to study the resistomes of bacterial communities isolated from different layers of the Canadian high Arctic permafrost, we show that microbial communities harbored diverse resistance mechanisms at least 5,000 years ago. Among bacteria sampled from the ancient layers of a permafrost core, we isolated eight genes conferring clinical levels of resistance against aminoglycoside, β-lactam and tetracycline antibiotics that are naturally produced by microorganisms. Among these resistance genes, four also conferred resistance against amikacin, a modern semi-synthetic antibiotic that does not naturally occur in microorganisms. In bacteria sampled from the overlaying active layer, we isolated ten different genes conferring resistance to all six antibiotics tested in this study, including aminoglycoside, β-lactam and tetracycline variants that are naturally produced by microorganisms as well as semi-synthetic variants produced in the laboratory. On average, we found that resistance genes found in permafrost bacteria conferred lower levels of resistance against clinically relevant antibiotics than resistance genes sampled from the active layer. Our results demonstrate that antibiotic resistance genes were functionally diverse prior to the anthropogenic use of antibiotics, contributing to the evolution of natural reservoirs of resistance genes. PMID:25807523

Comments by the Chairman

NASA Astrophysics Data System (ADS)

Fouillat, Pascal

2013-08-01

The European Conference on Radiation and its Effects on Components and Systems (RADECS 2012) was held on September 24-28, 2012, in Biarritz, France. The latest advances in the field of radiation effects on electronic and photonic materials, devices, circuits, sensors, and systems, were presented and discussed. The conference featured a Technical Program, an Industrial Exhibit, and one day meeting on radiation ground effects held on September 24 (RADGROUND). The conference gathered 390 attendees, scientists and engineers from 26 countries, with a high participation of France (101), USA (80), Russia (50), Spain (28), Germany (28), and U.K. (25). Raoul Velazco, from TIMA Labs, was in charge of the Technical Program, assisted by a Technical Program Committee listed below and a pool ofmore than 150 reviewers which contributed maintain the high level of quality reached since many years by the RADECS conferences. The total number of contributions reached 201 and each paper received at least four reviews. There were 145 papers accepted and presented in the Oral Sessions (48), Poster Sessions (69), and Data Workshop (28). The scope of the conference encompassed technological processes and design techniques for producing radiation tolerant systems for space, aeronautical or terrestrial applications, as well as relevant methodologies for their characterization and qualification. The Conference Record, gathering all the papers compliant with IEEE quality standards and editorial rules, is available through the IEEE Xplore Digital Library. The paper candidates and selected for publication in the IEEE TRANSACTIONS ON NUCLEAR SCIENCE will be published in this special issue.

Operation quality assessment model for video conference system

NASA Astrophysics Data System (ADS)

Du, Bangshi; Qi, Feng; Shao, Sujie; Wang, Ying; Li, Weijian

2018-01-01

Video conference system has become an important support platform for smart grid operation and management, its operation quality is gradually concerning grid enterprise. First, the evaluation indicator system covering network, business and operation maintenance aspects was established on basis of video conference system's operation statistics. Then, the operation quality assessment model combining genetic algorithm with regularized BP neural network was proposed, which outputs operation quality level of the system within a time period and provides company manager with some optimization advice. The simulation results show that the proposed evaluation model offers the advantages of fast convergence and high prediction accuracy in contrast with regularized BP neural network, and its generalization ability is superior to LM-BP neural network and Bayesian BP neural network.

Comparative Efficacy of Hemagglutinin, Nucleoprotein, and Matrix 2 Protein Gene-Based Vaccination against H5N1 Influenza in Mouse and Ferret

PubMed Central

Rao, Srinivas S.; Kong, Wing-Pui; Wei, Chih-Jen; Van Hoeven, Neal; Gorres, J. Patrick; Nason, Martha; Andersen, Hanne; Tumpey, Terrence M.; Nabel, Gary J.

2010-01-01

Efforts to develop a broadly protective vaccine against the highly pathogenic avian influenza A (HPAI) H5N1 virus have focused on highly conserved influenza gene products. The viral nucleoprotein (NP) and ion channel matrix protein (M2) are highly conserved among different strains and various influenza A subtypes. Here, we investigate the relative efficacy of NP and M2 compared to HA in protecting against HPAI H5N1 virus. In mice, previous studies have shown that vaccination with NP and M2 in recombinant DNA and/or adenovirus vectors or with adjuvants confers protection against lethal challenge in the absence of HA. However, we find that the protective efficacy of NP and M2 diminishes as the virulence and dose of the challenge virus are increased. To explore this question in a model relevant to human disease, ferrets were immunized with DNA/rAd5 vaccines encoding NP, M2, HA, NP+M2 or HA+NP+M2. Only HA or HA+NP+M2 vaccination conferred protection against a stringent virus challenge. Therefore, while gene-based vaccination with NP and M2 may provide moderate levels of protection against low challenge doses, it is insufficient to confer protective immunity against high challenge doses of H5N1 in ferrets. These immunogens may require combinatorial vaccination with HA, which confers protection even against very high doses of lethal viral challenge. PMID:20352112

High-resolution genetic and physical mapping of eastern filbert blight resistance in hazelnut

Treesearch

Vidyasagar Sathuvall; Shawn A. Mehlenbacher

2012-01-01

Eastern filbert blight (EFB), caused by the pyrenomycete Anisogramma anomala, is a serious threat to the hazelnut (Corylus avellana L.) industry in the Pacific Northwest. A dominant allele at a single locus from the obsolete pollenizer 'Gasaway' confers a very high level of resistance, and has been extensively used in...

When should we expect microbial phenotypic traits to predict microbial abundances?

PubMed

Fox, Jeremy W

2012-01-01

Species' phenotypic traits may predict their relative abundances. Intuitively, this is because locally abundant species have traits making them well-adapted to local abiotic and biotic conditions, while locally rare species are not as well-adapted. But this intuition may not be valid. If competing species vary in how well-adapted they are to local conditions, why doesn't the best-adapted species simply exclude the others entirely? But conversely, if species exhibit niche differences that allow them to coexist, then by definition there is no single best adapted species. Rather, demographic rates depend on species' relative abundances, so that phenotypic traits conferring high adaptedness do not necessarily confer high abundance. I illustrate these points using a simple theoretical model incorporating adjustable levels of "adaptedness" and "niche differences." Even very small niche differences can weaken or even reverse the expected correlation between adaptive traits and abundance. Conversely, adaptive traits confer high abundance when niche differences are very strong. Future work should be directed toward understanding the link between phenotypic traits and frequency-dependence of demographic rates.

Long-term evaluation of mucosal and systemic immunity and protection conferred by different polio booster vaccines.

PubMed

Xiao, Yuhong; Daniell, Henry

2017-09-25

Oral polio vaccine (OPV) and Inactivated Polio Vaccine (IPV) have distinct advantages and limitations. IPV does not provide mucosal immunity and introduction of IPV to mitigate consequences of circulating vaccine-derived polio virus from OPV has very limited effect on transmission and OPV campaigns are essential for interrupting wild polio virus transmission, even in developed countries with a high coverage of IPV and protected sewer systems. The problem is magnified in many countries with limited resources. Requirement of refrigeration for storage and transportation for both IPV and OPV is also a major challenge in developing countries. Therefore, we present here long-term studies on comparison of a plant-based booster vaccine, which is free of virus and cold chain with IPV boosters and provide data on mucosal and systemic immunity and protection conferred by neutralizing antibodies. Mice were primed subcutaneously with IPV and boosted orally with lyophilized plant cells containing 1μg or 25μg polio viral protein 1 (VP1), once a month for three months or a single booster one year after the first prime. Our results show that VP1-IgG1 titers in single or double dose IPV dropped to background levels after one year of immunization. This decrease correlated with >50% reduction in seropositivity in double dose and <10% seropositivity in single dose IPV against serotype 1. Single dose IPV offered no or minimal protection against serotype 1 and 2 but conferred protection against serotype 3. VP1-IgA titers were negligible in IPV single or double dose vaccinated mice. VP1 antigen with two plant-derived adjuvants induced significantly high level and long lasting VP1-IgG1, IgA and neutralizing antibody titers (average 4.3-6.8 log2 titers). Plant boosters with VP1 and plant derived adjuvants maintained the same level titers from 29 to 400days and conferred the same level of protection against all three serotypes throughout the duration of this study. Even during period, when no plant booster was given (∼260days), VP1-IgG1 titers were maintained at high levels. Lyophilized plant cells expressing VP1 can be stored without losing efficacy, eliminating cold chain. Virus-free, cold-chain free vaccine is ready for further clinical development. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

PREFACE: High Performance Computing Symposium 2011

NASA Astrophysics Data System (ADS)

Talon, Suzanne; Mousseau, Normand; Peslherbe, Gilles; Bertrand, François; Gauthier, Pierre; Kadem, Lyes; Moitessier, Nicolas; Rouleau, Guy; Wittig, Rod

2012-02-01

HPCS (High Performance Computing Symposium) is a multidisciplinary conference that focuses on research involving High Performance Computing and its application. Attended by Canadian and international experts and renowned researchers in the sciences, all areas of engineering, the applied sciences, medicine and life sciences, mathematics, the humanities and social sciences, it is Canada's pre-eminent forum for HPC. The 25th edition was held in Montréal, at the Université du Québec à Montréal, from 15-17 June and focused on HPC in Medical Science. The conference was preceded by tutorials held at Concordia University, where 56 participants learned about HPC best practices, GPU computing, parallel computing, debugging and a number of high-level languages. 274 participants from six countries attended the main conference, which involved 11 invited and 37 contributed oral presentations, 33 posters, and an exhibit hall with 16 booths from our sponsors. The work that follows is a collection of papers presented at the conference covering HPC topics ranging from computer science to bioinformatics. They are divided here into four sections: HPC in Engineering, Physics and Materials Science, HPC in Medical Science, HPC Enabling to Explore our World and New Algorithms for HPC. We would once more like to thank the participants and invited speakers, the members of the Scientific Committee, the referees who spent time reviewing the papers and our invaluable sponsors. To hear the invited talks and learn about 25 years of HPC development in Canada visit the Symposium website: http://2011.hpcs.ca/lang/en/conference/keynote-speakers/ Enjoy the excellent papers that follow, and we look forward to seeing you in Vancouver for HPCS 2012! Gilles Peslherbe Chair of the Scientific Committee Normand Mousseau Co-Chair of HPCS 2011 Suzanne Talon Chair of the Organizing Committee UQAM Sponsors The PDF also contains photographs from the conference banquet.

Back to the future: what would the post-2015 global development goals look like if we replicated methods used to construct the Millennium Development Goals?

PubMed Central

2014-01-01

Background The Millennium Development Goals (MDGs) were ‘top-down’ goals formulated by policy elites drawing from targets within United Nations (UN) summits and conferences in the 1990s. Contemporary processes shaping the new post-2015 development agenda are more collaborative and participatory, markedly different to the pre-MDG era. This study examines what would the outcome be if a methodology similar to that used for the MDGs were applied to the formulation of the post-2015 development goals (Post-2015DGs), identifying those targets arising from UN summits and conferences since the declaration of the MDGs, and aggregating them into goals. Methods The UN Department of Economic and Social Affairs (DESA) list of major UN summits and conferences from 2001 to 2012 was utilised to examine targets. The DESA list was chosen due to the agency’s core mission to promote development for all. Targets meeting MDG criteria of clarity, conciseness and measurability were selected and clustered into broad goals based on processes outlined by Hulme and Vandemoortele. The Post-2015DGs that were identified were formatted into language congruent with the MDGs to assist in the comparative analysis, and then further compared to the 12 illustrative goals offered by the UN High-Level Panel of Eminent Persons on the Post-2015 Development (High-Level Panel) Agenda’s May 2013 report. Results Ten Post-2015DGs were identified. Six goals expressly overlapped with the current MDGs and four new goals were identified. Health featured prominently in the MDG agenda, and continues to feature strongly in four of the 10 Post-2015DGs. However the Post-2015DGs reposition health within umbrella agendas relating to women, children and the ageing. Six of the 10 Post-2015DGs incorporate the right to health agenda, emphasising both the standing and interconnection of the health agenda in DESA’s summits and conferences under review. Two Post-2015DGs have been extended into six separate goals by the High-Level Panel, and it is these goals that are clearly linked to sustainable development diaspora. Conclusions This study exposes the evolving political agendas underplaying the current post-2015 process, as targets from DESA’s 22 major UN summits and conferences from 2001 to 2012 are not wholly mirrored in the HLP’s 12 goals. PMID:24708796

Back to the future: what would the post-2015 global development goals look like if we replicated methods used to construct the Millennium Development Goals?

PubMed

Brolan, Claire E; Lee, Scott; Kim, David; Hill, Peter S

2014-04-03

The Millennium Development Goals (MDGs) were 'top-down' goals formulated by policy elites drawing from targets within United Nations (UN) summits and conferences in the 1990s. Contemporary processes shaping the new post-2015 development agenda are more collaborative and participatory, markedly different to the pre-MDG era. This study examines what would the outcome be if a methodology similar to that used for the MDGs were applied to the formulation of the post-2015 development goals (Post-2015DGs), identifying those targets arising from UN summits and conferences since the declaration of the MDGs, and aggregating them into goals. The UN Department of Economic and Social Affairs (DESA) list of major UN summits and conferences from 2001 to 2012 was utilised to examine targets. The DESA list was chosen due to the agency's core mission to promote development for all. Targets meeting MDG criteria of clarity, conciseness and measurability were selected and clustered into broad goals based on processes outlined by Hulme and Vandemoortele. The Post-2015DGs that were identified were formatted into language congruent with the MDGs to assist in the comparative analysis, and then further compared to the 12 illustrative goals offered by the UN High-Level Panel of Eminent Persons on the Post-2015 Development (High-Level Panel) Agenda's May 2013 report. Ten Post-2015DGs were identified. Six goals expressly overlapped with the current MDGs and four new goals were identified. Health featured prominently in the MDG agenda, and continues to feature strongly in four of the 10 Post-2015DGs. However the Post-2015DGs reposition health within umbrella agendas relating to women, children and the ageing. Six of the 10 Post-2015DGs incorporate the right to health agenda, emphasising both the standing and interconnection of the health agenda in DESA's summits and conferences under review. Two Post-2015DGs have been extended into six separate goals by the High-Level Panel, and it is these goals that are clearly linked to sustainable development diaspora. This study exposes the evolving political agendas underplaying the current post-2015 process, as targets from DESA's 22 major UN summits and conferences from 2001 to 2012 are not wholly mirrored in the HLP's 12 goals.

Design of chimeric expression elements that confer high-level gene activity in chromoplasts.

PubMed

Caroca, Rodrigo; Howell, Katharine A; Hasse, Claudia; Ruf, Stephanie; Bock, Ralph

2013-02-01

Non-green plastids, such as chromoplasts, generally have much lower activity of gene expression than chloroplasts in photosynthetically active tissues. Suppression of plastid genes in non-green tissues occurs through a complex interplay of transcriptional and translational control, with the contribution of regulation of transcript abundance versus translational activity being highly variable between genes. Here, we have investigated whether the low expression of the plastid genome in chromoplasts results from inherent limitations in gene expression capacity, or can be overcome by designing appropriate combinations of promoters and translation initiation signals in the 5' untranslated region (5'-UTR). We constructed chimeric expression elements that combine promoters and 5'-UTRs from plastid genes, which are suppressed during chloroplast-to-chromoplast conversion in Solanum lycopersicum (tomato) fruit ripening, either just at the translational level or just at the level of mRNA accumulation. These chimeric expression elements were introduced into the tomato plastid genome by stable chloroplast transformation. We report the identification of promoter-UTR combinations that confer high-level gene expression in chromoplasts of ripe tomato fruits, resulting in the accumulation of reporter protein GFP to up to 1% of total cellular protein. Our work demonstrates that non-green plastids are capable of expressing genes to high levels. Moreover, the chimeric cis-elements for chromoplasts developed here are widely applicable in basic and applied research using transplastomic methods. © 2012 The Authors The Plant Journal © 2012 Blackwell Publishing Ltd.

PREFACE: International Conference on Fundamentals and Applications of HIPIMS

NASA Astrophysics Data System (ADS)

Ehiasarian, Arutiun; Bandorf, Ralf

2012-09-01

Thin film technology and surface engineering are nowadays key components for numerous innovative products like efficient windows, flat screens, sensors or hard coatings used in tool coating and automotive applications, as well as products for everyday life. In line with the demands of surface technology, coating technology is also evolving and improving. The latest major technology jump was the introduction of pulse technology in physical vapor deposition. High power impulse magnetron sputtering is the most recent development of pulse sputtering. After approximately a decade of intense academic investigation and development we observe today a transfer of this new technology towards industrial processes. As well as several international activities the international conference on fundamentals and applications of HIPIMS continues the success story of the HIPIMS days, initiated in 2004 at Sheffield Hallam University, UK. Becoming the only international conference especially dedicated to HIPIMS the HIPIMS conference is a venue for industrial and academic exchange on the latest developments in this fast evolving new technology. As a joint undertaking of Sheffield Hallam University SHU, Network of Competence for Industrial Plasma Surface Technology INPLAS and Fraunhofer Institute for Surface Engineering and Thin Films IST the HIPIMS conference was launched in 2010 in Sheffield, UK. With 120 delegates the impact of the new conference was underlined. The growing importance of HIPIMS technology was connected with a growth by nearly 35% to 160 participants in 2011 at the second HIPIMS conference in Braunschweig, DE. The participants were made up of equal numbers from research and development (university and research institutes) and industry. Being a global conference representatives from 25 different countries from all continents attended. The HIPIMS conference is also in joint collaboration with the COST Action MP0804 Highly Ionized Pulse Plasma Processes (www.hipp-cost.eu). COST (European Cooperation in Science and Technology) is one of the longest-running European frameworks supporting cooperation among scientists and researchers across Europe (www.cost.eu). The COST Action MP0804 HIPP processes focuses on the fundamentals and the industrial implementation of highly ionized pulse plasmas, where HIPIMS is the most prominent and most mature technology, today. Over 50 high level contributions, divided in 37 oral and 14 poster presentations were highly appreciated by the professional audience. The message from 2011 was that HIPIMS technology has now reached industry. In the opening session of the conference representatives from different companies reported on the latest developments in industrialization. Using HIPIMS technology, the lifetime of mills using a state of the art coating can be extended by 50%. Comparable deposition rates for coating cutting inserts on the different faces are reported. The ice-free window for automotive application is one solution just becoming available by HIPIMS technology. The talks from international experts covered a range from fundamental physics, experimental investigations, theoretically modeling to several applications and made the international conference on fundamentals and applications a success story to be continued in the following years. Arutiun Ehiasarian and Ralf Bandorf (Conference Chairmen of HIPIMS 2010 and 2011, respectively) Organising Committee (2010 and 2011) - Affiliations Professor Dr Papken Hovsepian (Sheffield Hallam University, Nanotechnology Center for PVD Research, UK) Professor Dr Günter Bräuer (Fraunhofer Institute for Surface Engineering and Thin Films IST/ Network of Competence INPLAS, Braunschweig, DE) Professor Dr Arutiun P. Ehiasarian (Sheffield Hallam University, Materials Research Institute, UK) Dr Ralf Bandorf (Fraunhofer Institute for Surface Engineering and Thin Films IST, Braunschweig, DE) Main Sponsor Society of Vacuum Coaters SVC Albuquerque, New Mexico, USA Sponsors Ionbond Netherlands BV Venlo, NL Hauzer Techno Coating BV Venlo, NL Hüttinger Elektronik GmbH + Co. KG Freiburg, DE Conference Photos Conference photograph Attendees HIPIMS Conference 2010, Sheffield, UK Conference photograph Attendees HIPIMS Conference 2011, Braunschweig, Germany

Activation of Antibiotic Production in Bacillus spp. by Cumulative Drug Resistance Mutations

PubMed Central

Tojo, Shigeo; Tanaka, Yukinori

2015-01-01

Bacillus subtilis strains produce a wide range of antibiotics, including ribosomal and nonribosomal peptide antibiotics, as well as bacilysocin and neotrehalosadiamine. Mutations in B. subtilis strain 168 that conferred resistance to drugs such as streptomycin and rifampin resulted in overproduction of the dipeptide antibiotic bacilysin. Cumulative drug resistance mutations, such as mutations in the mthA and rpsL genes, which confer low- and high-level resistance, respectively, to streptomycin, and mutations in rpoB, which confer resistance to rifampin, resulted in cells that overproduced bacilysin. Transcriptional analysis demonstrated that the enhanced transcription of biosynthesis genes was responsible for the overproduction of bacilysin. This approach was effective also in activating the cryptic genes of Bacillus amyloliquefaciens, leading to actual production of antibiotic(s). PMID:26369962

Thirteenth annual U.S. DOE low-level radioactive waste management conference: Proceedings

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1991-12-31

The 40 papers in this document comprise the proceedings of the Department of Energy`s Thirteenth Annual Low-Level Radioactive Waste Management Conference that was held in Atlanta, Georgia, on November 19--21, 1991. General subjects addressed during the conference included: disposal facility design; greater-than-class C low-level waste; public acceptance considerations; waste certification; site characterization; performance assessment; licensing and documentation; emerging low-level waste technologies; waste minimization; mixed waste; tracking and transportation; storage; and regulatory changes. Papers have been processed separately for inclusion on the data base.

The National Clinical Assessment Tool for Medical Students in the Emergency Department (NCAT-EM)

PubMed Central

Jung, Julianna; Franzen, Douglas; Lawson, Luan; Manthey, David; Tews, Matthew; Dubosh, Nicole; Fisher, Jonathan; Haughey, Marianne; House, Joseph B.; Trainor, Arleigh; Wald, David A.; Hiller, Katherine

2018-01-01

Introduction Clinical assessment of medical students in emergency medicine (EM) clerkships is a highly variable process that presents unique challenges and opportunities. Currently, clerkship directors use institution-specific tools with unproven validity and reliability that may or may not address competencies valued most highly in the EM setting. Standardization of assessment practices and development of a common, valid, specialty-specific tool would benefit EM educators and students. Methods A two-day national consensus conference was held in March 2016 in the Clerkship Directors in Emergency Medicine (CDEM) track at the Council of Residency Directors in Emergency Medicine (CORD) Academic Assembly in Nashville, TN. The goal of this conference was to standardize assessment practices and to create a national clinical assessment tool for use in EM clerkships across the country. Conference leaders synthesized the literature, articulated major themes and questions pertinent to clinical assessment of students in EM, clarified the issues, and outlined the consensus-building process prior to consensus-building activities. Results The first day of the conference was dedicated to developing consensus on these key themes in clinical assessment. The second day of the conference was dedicated to discussing and voting on proposed domains to be included in the national clinical assessment tool. A modified Delphi process was initiated after the conference to reconcile questions and items that did not reach an a priori level of consensus. Conclusion The final tool, the National Clinical Assessment Tool for Medical Students in Emergency Medicine (NCAT-EM) is presented here. PMID:29383058

Building leadership skills and promoting workforce development: evaluation data collected from public health professionals in the field of maternal and child health.

PubMed

Kroelinger, Charlan D; Kasehagen, Laurin; Barradas, Danielle T; 'Ali, Zarinah

2012-12-01

Professional development, including training and leadership skill building, is important for maternal and child health (MCH) epidemiologists. Current workforce development and training opportunities vary, but lack an emphasis on linking leadership competencies with MCH epidemiology. This paper describes efforts at the annual MCH Epidemiology Conference (the "Conference") to promote leadership activities and workforce development, and recommendations to enhance professional development. An evaluation of attendee opinions on Conference workforce development activities was conducted during the 2009 and 2010 Conferences (70 and 66 % response rates, respectively). Frequencies and percentages were calculated overall and by attendee profession. Qualitative responses to questions regarding workforce and professional development were classified by theme in 2009, and a categorical question was developed for the 2010 evaluation. A combined 38 % of Conference attendees in 2009 and 2010 were MCH epidemiologists and 62 % were other MCH professionals. Attendees recommended more support and access to training, mentoring, and resources including job opportunities. Continuing education (41 %), special knowledge and skills-building training (51 %), and development of online resources for training (57 %) were highly recommended by attendees. Career (47 %) and leadership (49 %) mentoring by senior-level professionals in the field were also highly recommended. Promotion of leadership can be achieved by integrating the concept of leadership into the Conference itself; by publishing and disseminating MCH epidemiologic research in scientific, program, and policy settings; and by communicating the importance of epidemiologic findings to stakeholders and other non-scientific audiences.

10th international conference on high-occupancy vehicle systems : conference proceedings

DOT National Transportation Integrated Search

2001-08-01

This report documents the proceedings from the 10th International High-Occupancy Vehicle (HOV) Systems Conference held in Dallas, Texas on August 27-30, 2000. The Conference was sponsored by the Transportation Research Board (TRB), in cooperation wit...

2017 The 7th International Conference on Computer Engineering and Networks

NASA Astrophysics Data System (ADS)

This conference proceeding is a collection of the papers accepted by the CENet 2017 - the 7th International Conference on Computer Engineering and Networks held on Shanghai from 22-23 July, 2017. This proceeding contains the five parts: Part I focuses on Machine learning (21 papers); Part II Wireless communication (21 papers); Part III Information theory (21 papers), Part IV Cloud science (14 papers) and Part V Data analysis (21 papers). Each part can be used as an excellent reference by industry practitioners, university faculty, and undergraduate as well as graduate students who need to build a knowledge base of the most current advances and state-of-practice in the topics covered by this conference proceedings. This will enable them to produce, maintain, and manage systems with high levels of trustworthiness and complexity Thanks go to the authors for their hard work and dedication as well as the reviewers for ensuring the selection of only the highest quality papers; their efforts made this proceedings possible.

VP2 (PTA motif) encoding DNA vaccine confers protection against lethal challenge with infectious pancreatic necrosis virus (IPNV) in trout.

PubMed

Ahmadivand, Sohrab; Soltani, Mehdi; Behdani, Mahdi; Evensen, Øystein; Alirahimi, Ehsan; Soltani, Elahe; Hassanzadeh, Reza; Ashrafi-Helan, Javad

2018-02-01

IPNV in Atlantic salmon is represented by various strains with different virulence and immunogenicity linked to various motifs of the VP2 capsid. IPNV variant with P 217 , T 221 , A 247 (PTA) motif is found to be avirulent in Atlantic salmon, but virulent in rainbow trout, and other salmonid species. This study describes a DNA vaccine delivered intramuscularly encoding the VP2 protein of infectious pancreatic necrosis virus (IPNV) with PTA motif that confers high protection in rainbow trout (Oncorhynchus mykiss). Intramuscular injection of 2, 5 and 10 μg of DNA (pcDNA3.1-VP2) in rainbow trout fry (4-5 g), confers relative protection of 75-83% in the different vaccine groups at 30 days post vaccination (450° days). The VP2 gene is expressed in spleen, kidney, muscle and liver at day 30 post-vaccination (RT-PCR), and IFN-1 and Mx-1 mRNA are upregulated at early time post vaccination, and so also for IgM, IgT, CD4 and CD8 in the head kidney of vaccinated fish compared to controls, 15 and 30 days post vaccination. Significant increase of serum anti-IPNV antibodies was found 30-90 days post-vaccination that was correlated with protection levels. Mortality corresponded with viral VP4 gene expression were significantly decreased in vaccinated and challenged fish. This shows for the first time that a VP2-encoding DNA vaccine delivered intramuscularly elicits a high level of protection alongside with high levels of circulating antibodies in rainbow trout and a lowered viral replication. Copyright © 2017 Elsevier Ltd. All rights reserved.

Abundance of Plasma Antioxidant Proteins Confers Tolerance to Acute Hypobaric Hypoxia Exposure

PubMed Central

Padhy, Gayatri; Sethy, Niroj Kumar; Ganju, Lilly

2013-01-01

Abstract Padhy, Gayatri, Niroj Kumar Sethy, Lilly Ganju, and Kalpana Bhargava. Abundance of plasma antioxidant proteins confers tolerance to acute hypobaric hypoxia exposure. High Alt Med Biol 14:289–297, 2013—Systematic identification of molecular signatures for hypobaric hypoxia can aid in better understanding of human adaptation to high altitude. In an attempt to identify proteins promoting hypoxia tolerance during acute exposure to high altitude, we screened and identified hypoxia tolerant and susceptible rats based on hyperventilation time to a simulated altitude of 32,000 ft (9754 m). The hypoxia tolerance was further validated by estimating 8-isoprotane levels and protein carbonyls, which revealed that hypoxia tolerant rats possessed significant lower plasma levels as compared to susceptible rats. We used a comparative plasma proteome profiling approach using 2-dimensional gel electrophoresis (2-DGE) combined with MALDI TOF/TOF for both groups, along with an hypoxic control group. This resulted in the identification of 19 differentially expressed proteins. Seven proteins (TTR, GPx-3, PON1, Rab-3D, CLC11, CRP, and Hp) were upregulated in hypoxia tolerant rats, while apolipoprotein A-I (APOA1) was upregulated in hypoxia susceptible rats. We further confirmed the consistent higher expression levels of three antioxidant proteins (PON1, TTR, and GPx-3) in hypoxia-tolerant animals using ELISA and immunoblotting. Collectively, these proteomics-based results highlight the role of antioxidant enzymes in conferring hypoxia tolerance during acute hypobaric hypoxia. The expression of these antioxidant enzymes could be used as putative biomarkers for screening altitude adaptation as well as aiding in better management of altered oxygen pathophysiologies. PMID:24067188

International conference on defects in insulating crystals

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1977-01-01

Short summaries of conference papers are presented. Some of the conference topics included transport properties, defect levels, superionic conductors, radiation effects, John-Teller effect, electron-lattice interactions, and relaxed excited states. (SDF)

Identification of immunogenic proteins within distinct molecular mass fractions of Flavobacterium psychrophilum

USDA-ARS?s Scientific Manuscript database

Flavobacterium psychrophilum is the etiologic agent of bacterial coldwater disease (CWD) and this pathogen has large economic impacts on salmonid aquaculture worldwide. Previously, it was demonstrated that high levels of protection against F. psychrophilum challenge were conferred to rainbow trout,...

School-College Collaboration and the Teaching of English: Deja Vu All over Again?

ERIC Educational Resources Information Center

Harris, Charles B.

1995-01-01

Traces the historically optimistic view of college-secondary school cooperation. Asks why such optimism has faded in recent years. Considers how college-level departments of English can collaborate with high school English programs, such as in collaborative conferences. (HB)

Differential KrasV12 protein levels control a switch regulating lung cancer cell morphology and motility

PubMed Central

Schäfer, C.; Mohan, A.; Burford, W.; Driscoll, M. K.; Ludlow, A. T.; Wright, W. E.; Shay, J. W.; Danuser, G.

2016-01-01

Introduction Oncogenic Kras mutations are important drivers of lung cancer development and metastasis. They are known to activate numerous cellular signaling pathways implicated in enhanced proliferation, survival, tumorigenicity and motility during malignant progression. Objectives Most previous studies of Kras in cancer have focused on the comparison of cell states in the absence or presence of oncogenic Kras mutations. Here we show that differential expression of the constitutively active mutation KrasV12 has profound effects on cell morphology and motility that drive metastatic processes. Methods The study relies on lung cancer cell transformation models, patient-derived lung cancer cell lines, and human lung tumor sections combined with molecular biology techniques, live-cell imaging and staining methods. Results Our analysis shows two cell functional states driven by KrasV12 protein levels: a non-motile state associated with high KrasV12 levels and tumorigenicity, and a motile state associated with low KrasV12 levels and cell dissemination. Conversion between the states is conferred by differential activation of a mechano-sensitive double-negative feedback between KrasV12/ERK/Myosin II and matrix-adhesion signaling. KrasV12 expression levels change upon cues such as hypoxia and integrin-mediated cell-matrix adhesion, rendering KrasV12 levels an integrator of micro-environmental signals that translate into cellular function. By live cell imaging of tumor models we observe shedding of mixed high and low KrasV12 expressers forming multi-functional collectives with potentially optimal metastatic properties composed of a highly mobile and a highly tumorigenic unit. Discussion Together these data highlight previously unappreciated roles for the quantitative effects of expression level variation of oncogenic signaling molecules in conferring fundamental alterations in cell function regulation required for cancer progression. PMID:29057096

XVII International AIDS Conference: From Evidence to Action - Social, behavioural and economic science and policy and political science.

PubMed

Mykhalovskiy, Eric; Brown, Glen; Kort, Rodney

2009-10-06

AIDS 2008 firmly established stigma and discrimination as fundamental priorities in the push for universal access to HIV prevention, treatment, care and support. Conference sessions and discussions reinforced the tangible negative effects of stigma on national legislation and policies. A strong theme throughout the conference was the need to replace prevention interventions that focus exclusively on individual behaviour change or biomedical prevention interventions with "combination prevention" approaches that address both individual and structural factors that increase vulnerability to HIV infection.Several high-level sessions addressed various aspects of the debate over "vertical" (disease-specific) versus "horizontal" (health systems) funding. The majority of evidence presented at the conference suggests that HIV investments strengthen health systems through the establishment of clinical and laboratory infrastructure, strengthened supply and procurement systems, improvements in health care worker training, and increased community engagement.Human rights were a focal point at the conference; several presentations emphasized the importance of securing human rights to achieve universal access goals, including workplace discrimination, travel restrictions, gender inequality, and the criminalization of homosexuality, drug use, sex work, and HIV transmission and/or exposure.

XVII International AIDS Conference: From Evidence to Action - Social, behavioural and economic science and policy and political science

PubMed Central

2009-01-01

AIDS 2008 firmly established stigma and discrimination as fundamental priorities in the push for universal access to HIV prevention, treatment, care and support. Conference sessions and discussions reinforced the tangible negative effects of stigma on national legislation and policies. A strong theme throughout the conference was the need to replace prevention interventions that focus exclusively on individual behaviour change or biomedical prevention interventions with "combination prevention" approaches that address both individual and structural factors that increase vulnerability to HIV infection. Several high-level sessions addressed various aspects of the debate over "vertical" (disease-specific) versus "horizontal" (health systems) funding. The majority of evidence presented at the conference suggests that HIV investments strengthen health systems through the establishment of clinical and laboratory infrastructure, strengthened supply and procurement systems, improvements in health care worker training, and increased community engagement. Human rights were a focal point at the conference; several presentations emphasized the importance of securing human rights to achieve universal access goals, including workplace discrimination, travel restrictions, gender inequality, and the criminalization of homosexuality, drug use, sex work, and HIV transmission and/or exposure. PMID:19811671

Building Leadership Skills and Promoting Workforce Development: Evaluation Data Collected from Public Health Professionals in the Field of Maternal and Child Health

PubMed Central

Kasehagen, Laurin; Barradas, Danielle T.; ‘Ali, Zarinah

2015-01-01

Professional development, including training and leadership skill building, is important for maternal and child health (MCH) epidemiologists. Current workforce development and training opportunities vary, but lack an emphasis on linking leadership competencies with MCH epidemiology. This paper describes efforts at the annual MCH Epidemiology Conference (the “Conference”) to promote leadership activities and workforce development, and recommendations to enhance professional development. An evaluation of attendee opinions on Conference workforce development activities was conducted during the 2009 and 2010 Conferences (70 and 66 % response rates, respectively). Frequencies and percentages were calculated overall and by attendee profession. Qualitative responses to questions regarding workforce and professional development were classified by theme in 2009, and a categorical question was developed for the 2010 evaluation. A combined 38 % of Conference attendees in 2009 and 2010 were MCH epidemiologists and 62 % were other MCH professionals. Attendees recommended more support and access to training, mentoring, and resources including job opportunities. Continuing education (41 %), special knowledge and skills-building training (51 %), and development of online resources for training (57 %) were highly recommended by attendees. Career (47 %) and leadership (49 %) mentoring by senior-level professionals in the field were also highly recommended. Promotion of leadership can be achieved by integrating the concept of leadership into the Conference itself; by publishing and disseminating MCH epidemiologic research in scientific, program, and policy settings; and by communicating the importance of epidemiologic findings to stakeholders and other non-scientific audiences. PMID:22923283

Translations on Eastern Europe, Scientific Affairs, Number 591.

DTIC Science & Technology

1978-07-10

of the Sea conferences and negotiations, territorial seas and straits, coastal and international seabed economic areas, marine pollution...technological levels, and the economic effectiveness of their production. The People’s Republic of Bulgaria, for example, is the second country in...optimization of the technological processes and achieving high technical- economic para- meters—merit a particularly high appraisal. In this context, we

Activation of Antibiotic Production in Bacillus spp. by Cumulative Drug Resistance Mutations.

PubMed

Tojo, Shigeo; Tanaka, Yukinori; Ochi, Kozo

2015-12-01

Bacillus subtilis strains produce a wide range of antibiotics, including ribosomal and nonribosomal peptide antibiotics, as well as bacilysocin and neotrehalosadiamine. Mutations in B. subtilis strain 168 that conferred resistance to drugs such as streptomycin and rifampin resulted in overproduction of the dipeptide antibiotic bacilysin. Cumulative drug resistance mutations, such as mutations in the mthA and rpsL genes, which confer low- and high-level resistance, respectively, to streptomycin, and mutations in rpoB, which confer resistance to rifampin, resulted in cells that overproduced bacilysin. Transcriptional analysis demonstrated that the enhanced transcription of biosynthesis genes was responsible for the overproduction of bacilysin. This approach was effective also in activating the cryptic genes of Bacillus amyloliquefaciens, leading to actual production of antibiotic(s). Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Projections of Education Statistics to 2001: An Update.

ERIC Educational Resources Information Center

Gerald, Debra E.; Hussar, William J.

Statistical projections for elementary and secondary schools and institutions of higher education are provided at the national and state levels through the year 2001. National projection tables cover enrollment, high school graduates, earned degrees conferred, classroom teachers, and expenditures of public elementary and secondary schools.…

Greening the University Curriculum: Appraising an International Movement

ERIC Educational Resources Information Center

Haigh, Martin

2005-01-01

The declaration of the "United Nations Decade of Education for Sustainable Development" (ESD), Resolution 57/254, February 2003, provides the best yet occasion for higher education institutions (HEIs) to "green" their curricula. The idea for the Decade emerges from a progression of high-level international conferences,…

Alum adjuvanted rabies DNA vaccine confers 80% protection against lethal 50 LD50 rabies challenge virus standard strain.

PubMed

Garg, Rajni; Kaur, Manpreet; Saxena, Ankur; Prasad, Rajendra; Bhatnagar, Rakesh

2017-05-01

Rabies is a serious concern world-wide. Despite availability of rabies vaccines for long; their efficacy, safety, availability and cost effectiveness has been a tremendous issue. This calls for improvement of rabies vaccination strategies. DNA vaccination has immense potential in this regard. The DNA vaccine pgp.LAMP-1 conferred 60% protection to BALB/c mice against 20 LD 50 rabies challenge virus standard (CVS) strain challenge. Upon supplementation with Emulsigen-D, the vaccine formulation conferred complete protection against lethal challenge. To assess the feasibility of this vaccine formulation for human use, it was tested along with other FDA approved adjuvants, namely, Alum, Immuvac, Montanide ISA720 VG. Enhanced immune response correlated with high IgG antibody titer, Th2 biased response with a high level of rabies virus neutralizing antibodies (RVNAs) and IgG1/IgG2a ratio >1, observed upon alum supplementation of the rabies DNA vaccine. The total IgG antibody titer was 2IU/ml and total RVNA titer was observed to be 4IU/ml which is eight times higher than the minimum protective titer recommended by WHO. Furthermore, it conferred 80% protection against challenge with 50 LD 50 of the rabies CVS strain, conducted in compliance with the potency test for rabies recommended by the National Institutes of Health (NIH), USA. Previously, we have established pre-clinical safety of this vaccine as per the guidelines of Schedule Y, FDA as well as The European Agency for evaluation of Medicinal Products. The vaccine showed no observable toxicity at the site of injection as well as at systemic level in Wistar rats when administered with 10X recommended dose. Therefore, supplementation of rabies DNA vaccine, pgp.LAMP-1 with alum would lead to development of a non-toxic, efficacious, stable and affordable vaccine that can be used to combat high numbers of fatal rabies infections tormenting developing countries. Copyright © 2017 Elsevier Ltd. All rights reserved.

ISMB Conference Funding to Support Attendance of Early Researchers and Students

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gaasterland, Terry

ISMB Conference Funding for Students and Young Scientists Historical Description The Intelligent Systems for Molecular Biology (ISMB) conference has provided a general forum for disseminating the latest developments in bioinformatics on an annual basis for the past 22 years. ISMB is a multidisciplinary conference that brings together scientists from computer science, molecular biology, mathematics and statistics. The goal of the ISMB meeting is to bring together biologists and computational scientists in a focus on actual biological problems, i.e., not simply theoretical calculations. The combined focus on “intelligent systems” and actual biological data makes ISMB a unique and highly important meeting.more » 21 years of experience in holding the conference has resulted in a consistently well-organized, well attended, and highly respected annual conference. "Intelligent systems" include any software which goes beyond straightforward, closed-form algorithms or standard database technologies, and encompasses those that view data in a symbolic fashion, learn from examples, consolidate multiple levels of abstraction, or synthesize results to be cognitively tractable to a human, including the development and application of advanced computational methods for biological problems. Relevant computational techniques include, but are not limited to: machine learning, pattern recognition, knowledge representation, databases, combinatorics, stochastic modeling, string and graph algorithms, linguistic methods, robotics, constraint satisfaction, and parallel computation. Biological areas of interest include molecular structure, genomics, molecular sequence analysis, evolution and phylogenetics, molecular interactions, metabolic pathways, regulatory networks, developmental control, and molecular biology generally. Emphasis is placed on the validation of methods using real data sets, on practical applications in the biological sciences, and on development of novel computational techniques. The ISMB conferences are distinguished from many other conferences in computational biology or artificial intelligence by an insistence that the researchers work with real molecular biology data, not theoretical or toy examples; and from many other biological conferences by providing a forum for technical advances as they occur, which otherwise may be shunned until a firm experimental result is published. The resulting intellectual richness and cross-disciplinary diversity provides an important opportunity for both students and senior researchers. ISMB has become the premier conference series in this field with refereed, published proceedings, establishing an infrastructure to promote the growing body of research.« less

Publication rate of abstracts presented at European Paediatric Orthopaedic Society Annual Meetings, 2006 to 2008.

PubMed

Kleine-Konig, Marie-Theres; Schulte, Tobias L; Gosheger, Georg; Rödl, Robert; Schiedel, Frank M

2014-09-01

The quality of the abstracts presented at a conference reflects the scientific work and level of activity of the scientific association concerned. The aim of the present study was to determine the rate of publications of podium presentations and posters at the conferences of the European Paediatric Orthopaedic Society (EPOS) from 2006 to 2008 and to identify factors that favor publication in peer-reviewed journals. The results are compared with those of other international societies. All 646 abstracts (including podiums, posters, and e-posters) presented at the EPOS conferences were investigated using the PubMed database to identify any corresponding published articles in the journals listed in the database. A period of 5 years before and after the relevant conference was used for the PubMed search. Factors influencing publication and the quality of the study, such as the type of presentation and the level of evidence, were also investigated. A publication rate of 36.7% was observed, corresponding to 237 publications of 646 abstracts. The period to publication showed a mean of 13.88 ± 1.34 months. It was found that abstracts of podium presentations were published significantly more often than poster abstracts (P<0.001). Experimental studies, with a publication rate of 50.9%, showed better results than clinical studies (36.0%). Overall, the articles were published in 61 different journals, with the largest number (n=50) appearing in the Journal of Pediatric Orthopaedics. In addition, the present study shows that abstracts with a higher level of evidence were associated with a higher publication rate. At 36.7%, the rate of publication of EPOS abstracts is within the range reached by other specialist orthopaedics societies, such as the German Society of Orthopaedics and Trauma Surgery (36%) and the British Orthopaedic Association (36%). However, it is lower than the publication rate of the Pediatric Orthopaedic Society of North America (POSNA), at 50%. The high percentage of unpublished conference abstracts (63%), which did not go through a peer-reviewed process, casts doubts upon the practice of utilizing the citation of abstracts based purely on conference abstracts. Statistical study.

Consultation-Conference on Developmental Disabilities and Gerontology. Proceedings of a Conference (Ann Arbor, Michigan, May 8-10, 1978).

ERIC Educational Resources Information Center

Segal, Robert M., Ed.

This document contains the proceedings from the National Conference on Developmental Disabilities and Gerontology, a conference designed to develop guidelines for program development on national, state, and local levels; develop and disseminate a proceedings publication; and provide an interface between professionals working at national, state,…

[Regional health and autonomy conferences (CRSAs): the implications for medical democracy at a regional level].

PubMed

Devictor, Bernadette

2010-01-01

The HPST law seeks to reorganize the governance of healthcare at a regional level and to maintain the existence of regional health conferences, now known as regional health and autonomy conferences (CRSAs). The purpose of this article is to examine the new duties attributed to the CRSAs and to consider the various issues raised by their practice. The article also provides an analysis of the preconditions required for the successful implementation of medical democracy at a regional level, ie.: the involvement of the CRSAs in the assessment of regional healthcare policies, the mobilization of funds, the composition of the CRSAs (including the full range of healthcare areas), the importance of providing adequate support for territorial conferences, and the elaboration of a communicative space for fostering exchanges between CRSAs.

Feminism, Budgeting and Gender Justice

ERIC Educational Resources Information Center

Misra, S. N.; Ghadai, Sanjaya Kumar

2017-01-01

The Fourth Conference on Women at Beijing (1995) underlined the importance of gender mainstreaming; spurring India to provide for separate Gender Budgeting in 2005-06. The Constitution tries to make fine balance between right to equality and positive discrimination for promoting gender justice in India. Yet high levels of Gender Inequality Index…

Tolerance to powdery mildew conferred in susceptible watermelon scion by grafting on resistant rootstocks

USDA-ARS?s Scientific Manuscript database

Cucurbit powdery mildew (PM) caused by Podosphaera xanthii, can impact seedling growth and cause serious losses in greenhouse and open field production. We have developed several watermelon and bottle gourd germplasm lines with high levels of resistance to PM. A PM susceptible cultivar Mickey Lee ...

Powdery mildew resistant cucurbit rootstocks confer tolerance to grafted susceptible watermelon scions

USDA-ARS?s Scientific Manuscript database

Cucurbit powdery mildew (PM) caused by Podosphaera xanthii can impact seedling growth and cause serious losses in greenhouse and open fields. We have developed watermelon and bottle gourd germplasm lines with high levels of resistance to PM. A PM susceptible watermelon cultivar Mickey Lee (ML) was g...

Iraq: Regional Perspectives and U.S. Policy

DTIC Science & Technology

2008-12-01

conference on Iraq that was held in November 2004, in Sharm al Shaykh, Egypt, which included high level representatives from Iraq, its key neighbors...engagement with Syria and Iran expanded after early 2007. The International Compact for Iraq was adopted in May 2007 at a two-day summit in Sharm al

Back to the Future with Business and Marketing Education. Annual Atlantic Coast Business and Marketing Education Conference Proceedings (12th, Raleigh, North Carolina, February 17-18, 1995).

ERIC Educational Resources Information Center

Joyner, Randy L., Ed.

This proceedings includes: "Bridging the International Learning Gap" (Arnold); "Back to the Future" (Baker); "Conducting Successful Class Projects over the Internet" (Beasley); "The Need for Ethics Instruction at the High School Level" (Brown); "Incorporating Industry-Based Skills Standards into High School Secretarial Programs" (Bunn);…

Roster of Physics Departments with Enrollment and Degree Data, 2015: Results from the 2015 Survey of Enrollments and Degrees. Focus On

ERIC Educational Resources Information Center

Nicholson, Starr; Mulvey, Patrick J.

2016-01-01

Physics bachelor's degree production continues to increase, with the 8,122 bachelor's awarded representing yet another all-time high. Further increases in physics bachelor's degree production are anticipated as undergraduate junior- and senior-level enrollments continue to climb. The all-time high of 1,860 physics PhDs conferred in the class of…

Roster of Astronomy Departments with Enrollment and Degree Data, 2015: Results from the 2015 Survey of Enrollments and Degrees. Focus On

ERIC Educational Resources Information Center

Nicholson, Starr; Mulvey, Patrick J.

2016-01-01

Physics bachelor's degree production continues to increase, with the 8,122 bachelor's awarded representing yet another all-time high. Further increases in physics bachelor's degree production are anticipated as undergraduate junior- and senior-level enrollments continue to climb. The all-time high of 1,860 physics PhDs conferred in the class of…

[A new star in the sky of psychiatry: The European College of Neuropsychopharmacology].

PubMed

Gabay, Pablo M

2014-01-01

A commentary about the activities of the ECNP, whose congresses have become a new destination for many professionals interested in clinic and high level research in psychiatry and brain is made. The author presents the goals of the ECNP, the meeting activities in general, and, in particular, the press conferences that took place during the congresses. The 26th Congress (Barcelona, Spain, October, 2013) and the 27th Congress (Berlin, Germany, October, 2014) are reviewed. The high scientific level of both congresses is highlighted.

PREFACE: International Conference on High Pressure Science and Technology, Joint AIRAPT-22 & HPCJ-50

NASA Astrophysics Data System (ADS)

Viña, Luis; Tejedor, Carlos; Calleja, José M.

2010-01-01

The International Joint AIRAPT-22 & HPCJ-50 Conference was held in Odaiba, Tokyo, on 26-31 July 2009. About 480 scientists from 24 countries attended the conference and 464 papers, including 3 plenary lectures, 39 invited talks, and 156 oral presentations, were presented. It is my great pleasure to present this proceedings volume, which is based on the high quality scientific works presented at the conference. The International AIRAPT conference has been held every two years in various countries around the world since 1965, while High Pressure Conference of Japan (HPCJ) has been held annually since 1959 in various Japanese cities. Pressure is a fundamental parameter to control the property of matter. As a result, both AIRAPT and HPCJ have become highly multidisciplinary, and cover Physics, Chemistry, Materials Science, Earth and Planetary Sciences, Biosciences, Food Science, and Technology. Although each discipline has a unique target, they all have high-pressure research in common. This proceedings volume includes about 200 papers of state-of-the-art studies from numerous fields. I hope this proceedings volume provides excellent pieces of information in various fields to further advance high-pressure research. Conference logo Takehiko Yagi Conference Chairman Institute for Solid State Physics The University of Tokyo 7 December 2009 Conference photograph Participants at the conference venue, Tokyo International Exchange Center, Odaiba, Tokyo, Japan. Editor in Chief TAKEMURA Kenichi National Institute for Materials Science, Japan Editorial board Tadashi KONDO Osaka University, Japan Hitoshi MATSUKI The University of Tokushima, Japan Nobuyuki MATUBAYASI Kyoto University, Japan Yoshihisa MORI Okayama University of Science, Japan Osamu OHTAKA Osaka University, Japan Chihiro SEKINE Muroran Institute of Technology, Japan

[Online-conference using JGN.].

PubMed

Nakayama, Kazuya; Kojima, Kazuhiko; Suzuki, Masayuki; Kikuchi, Yuzo; Iwahara, Masayoshi; Matsui, Osamu; Noguchi, Masato

2004-01-01

Telemedicine and online conference systems have some benefits so that equalizing medical level, improving efficiency of medical care and improving service for patients. It is possible to give advice and to support its medical projects stationed in other facility and to provide the same quality treatments for patients. In this paper, we set up an experimental network system to teleconference using JGN (Japan Gigabit Network) and tried to discussion alternatively for case study between Kanazawa university and Fukui red cross hospital, 70 km away. The JGN used in this study is an ultra-high-speed network for the purpose of research and development. Kanazawa university, and Fukui red cross hospital are connected by a 10 Mbps communication link of the JGN. We tried online conference on the experimental network using video chat system. In result, using video chat system, the average transmission rate of MRI images (256 X 256pixel, 16bit) is 0.2 s/frame.

Proceedings ICASS 2017

NASA Astrophysics Data System (ADS)

Fu, Qiang; Schaaf, Peter

2018-07-01

This special issue of the high impact international peer reviewed journal Applied Surface Science represents the proceedings of the 2nd International Conference on Applied Surface Science ICASS held 12-16 June 2017 in Dalian China. The conference provided a forum for researchers in all areas of applied surface science to present their work. The main topics of the conference are in line with the most popular areas of research reported in Applied Surface Science. Thus, this issue includes current research on the role and use of surfaces in chemical and physical processes, related to catalysis, electrochemistry, surface engineering and functionalization, biointerfaces, semiconductors, 2D-layered materials, surface nanotechnology, energy, new/functional materials and nanotechnology. Also the various techniques and characterization methods will be discussed. Hence, scientific research on the atomic and molecular level of material properties investigated with specific surface analytical techniques and/or computational methods is essential for any further progress in these fields.

PREFACE: 16th International Conference on Calorimetry in High Energy Physics (CALOR 2014)

NASA Astrophysics Data System (ADS)

Novotny, Rainer W.

2015-02-01

The XVIth International Conference on Calorimetry in High Energy Physics - CALOR 2014 - was held in Giessen, Germany from 6-11 April 2014 at the Science Campus of the University. It was hosted by the Justus-Liebig-University and the HIC for FAIR Helmholtz International Center. The series of conferences on calorimetry were started in 1990 at Fermilab and are focusing primarily on operating and future calorimeter systems within the Hadron and High-Energy Physics community without neglecting the impact on other fields such as Astrophysics or Medical Imaging. Confirmed by the impressive list of over 70 oral presentations, 5 posters and over 100 attendees, the field of calorimetry appears alive and attractive. The present volume contains the written contributions of almost all presentations which can be found at http://calor2014.de. Time slots of 15 or 30 minutes including discussion were allocated. The conference was accompanied by a small exhibition of several industrial companies related to the field. The day before the opening of the scientific program, Richard Wigmans gave an excellent and vivid tutorial on basic aspects on calorimetry meant as an introduction for students and conference attendees new in the field. The opening ceremony was used to give an impression of the present and future status and the scientific program of the new FAIR facility nearby at Darmstadt presented by Klaus Peters from GSI. The conference program of the first day was dedicated to the performance and required future upgrade of the LHC experiments, dominated by ATLAS, CMS and LHCb. The program of the next day contained specific aspects on electronics and readout as well as calorimetry in outer space. Several contributions discussed in detail new concepts for hadron calorimeters within the CALICE collaboration completed by a session on sampling calorimeters. The next sections were dedicated to operating and future calorimeters at various laboratories and covering a wide range of projectiles and beam energies, such as ELSA at Bonn, BELLE2, BESIII or future projects at JLab, FAIR or RHIC. The last group of contributions was focusing on new concepts including new detector materials or techniques taking into account the general demand on radiation hardness. Damage caused by a large fluence of hadrons appears to become the limiting factor for the detector performance in future collider experiments. The scientific program was completed by a single contribution on applications in medical imaging. Marcella Diemoz gave a personal conference summary underlining again the high quality of the presentations, lively discussions and the wide range of the physics program and the related detector systems. The significant support by the Justus-Liebig-University, HIC for FAIR and sponsoring industrial partners allowed to keep the overall costs low and to support the participation of students and young scientists. I personally would like to thank the session chairs, the local organizing committee, the secretaries, technicians and students of the institute for the smooth operation of the conference. Finally, I would like to express my appreciation to all participants who made the conference successful by their high level contributions and discussion distributing their ideas and experiences. Rainer W Novotny Chair of the Conference

FOREWORD: The 4th CCM International Conference on Pressure Metrology from Ultra-High Vacuum to Very High Pressures (10-9 Pa to 109 Pa)

NASA Astrophysics Data System (ADS)

Legras, Jean-Claude; Jousten, Karl; Severn, Ian

2005-12-01

The fourth CCM (Consultative Committee for Mass and related quantities) International Conference on Pressure Metrology from Ultra-High Vacuum to Very High Pressures (10-9 Pa to 109 Pa) was held at the Institute of Physics in London from 19-21 April 2005. The event, which was organized by the Low, Medium and High Pressure working groups of the CCM, was attended by in excess of one hundred participants with representatives from five continents and every regional metrology organization. The purpose of this conference is to review all the work that is devoted to the highest quality of pressure measurement by primary standards as well as the dissemination of the pressure scale. A total of 52 papers were presented orally, and 26 as posters, in sessions that covered the following topics: Latest scientific advances in pressure and vacuum metrology Innovative transfer standards, advanced sensors and new instrument development Primary (top-level) measurement standards International and regional key comparisons New approaches to calibration It is interesting the note that since the third conference in 1999 the pressure range covered has increased by two orders of magnitude to 109 Pa, to take into account more exacting scientific and industrial demands for traceable vacuum measurement. A further feature of the conference was the increased range of instrumentation and techniques used in the realization and potential realization of pressure standards. Seton Bennett, Director of International Metrology at the National Physical Laboratory, opened the conference and Andrew Wallard, Director of the Bureau International des Poids et Mesures (BIPM), gave the keynote address which described the implementation of the mutual recognition arrangement and the resulting removal of metrological barriers to international trade. Many experts have contributed significant amounts of their time to organize the event and to review the submitted papers. Thanks are due to all of these people, particularly Gianfranco Molinar who offered much advice based on experience of organizing the previous conference. Special thanks must also be made to Mitsuru Tanaka, President of the CCM, and Andrew Wallard, Director of the BIPM, for their support of the event. The event was coordinated by Jasmina Bolfek-Radovani, of the Institute of Physics, without whose tireless efforts the event would not have been as successful. The production of this issue of Metrologia would not have been possible without the help and support of its editor, Jeffrey Williams. The National Measurement System Directorate of the Department of Trade and Industry supported the conference and it was sponsored by DH Instruments and BOC Edwards. Additional financial assistance was also received from Chell Instruments Ltd, DH-Budenberg, GE Infrastructure Sensing, Hi-Pro Pressure Products Ltd, Kurt J Lesker Company Ltd and Leybold Vacuum UK Ltd. Finally we would like to thank all of the conference participants who made the event both technically stimulating and enjoyable. By the time the next CCM Pressure conference is held in Berlin in 2011, pressure science and technology will undoubtedly have moved on still further and we may see the culmination of work to realize primary pressure standards by more fundamental methods.

Two-Year College Chemistry Conference Proceedings: Eastern Regional Conference (2nd, Boston, October 11-12, 1968); Annual Conference (9th, Minneapolis, April 11-12, 1969); and Western Regional Conference (3rd, Salt Lake City, June 13-14, 1969).

ERIC Educational Resources Information Center

Chapman, Kenneth, Ed.

This document includes contributed short papers and summaries of recorded remarks from four meetings of the 1968-1969 Two-Year College Chemistry Conferences. Topics include the two-year college chemistry teacher, chemistry laboratories, teaching first-year college chemistry, a sophomore level chemistry course for both majors and nonmajors, organic…

Reduction in mRNA and protein expression of a nicotinic acetylcholine receptor α8 subunit is associated with resistance to imidacloprid in the brown planthopper, Nilaparvata lugens.

PubMed

Zhang, Yixi; Wang, Xin; Yang, Baojun; Hu, Yuanyuan; Huang, Lixin; Bass, Chris; Liu, Zewen

2015-11-01

Target-site resistance is commonly caused by qualitative changes in insecticide target-receptors and few studies have implicated quantitative changes in insecticide targets in resistance. Here we show that resistance to imidacloprid in a selected strain of Nilaparvata lugens is associated with a reduction in expression levels of the nicotinic acetylcholine receptor (nAChR) subunit Nlα8. Synergism bioassays of the selected strain suggested resistance was conferred, in part, by a target-site mechanism. Sequencing of N. lugens nAChR subunit genes identified no mutations associated with resistance, however, a decrease in mRNA and protein levels of Nlα8 was observed during selection. RNA interference knockdown of Nlα8 decreased the sensitivity of N. lugens to imidacloprid, demonstrating that a decrease in Nlα8 expression is sufficient to confer resistance in vivo. Radioligand binding assays revealed that the affinity of the high-affinity imidacloprid-binding site of native nAChRs was reduced by selection, and reducing the amount of Nlα8 cRNA injected into Xenopus oocytes significantly decreased imidacloprid potency on recombinant receptors. Taken together, these results provide strong evidence that a decrease in Nlα8 levels confers resistance to imidacloprid in N. lugens, and thus provides a rare example of target-site resistance associated with a quantitative rather than qualitative change. In insects, target-site mutations often cause high resistance to insecticides, such as neonicotinoids acting on nicotinic acetylcholine receptors (nAChRs). Here we found that a quantitative change in target-protein level, decrease in mRNA and protein levels of Nlα8, contributed importantly to imidacloprid resistance in Nilaparvata lugens. This finding provides a new target-site mechanism of insecticide resistance. © 2015 International Society for Neurochemistry.

The Allegheny initiative for mental health integration for the homeless: integrating heterogeneous health services for homeless persons.

PubMed

Gordon, Adam J; Montlack, Melissa L; Freyder, Paul; Johnson, Diane; Bui, Thuy; Williams, Jennifer

2007-03-01

The Allegheny Initiative for Mental Health Integration for the Homeless (AIM-HIGH) was a 3-year urban initiative in Pennsylvania that sought to enhance integration and coordination of medical and behavioral services for homeless persons through system-, provider-, and client-level interventions. On a system level, AIM-HIGH established partnerships between several key medical and behavioral health agencies. On a provider level, AIM-HIGH conducted 5 county-wide conferences regarding homeless integration, attended by 637 attendees from 72 agencies. On a client level, 5 colocated medical and behavioral health care clinics provided care to 1986 homeless patients in 4084 encounters, generating 1917 referrals for care. For a modest investment, AIM-HIGH demonstrated that integration of medical and behavioral health services for homeless persons can occur in a large urban environment.

The Allegheny Initiative for Mental Health Integration for the Homeless: Integrating Heterogeneous Health Services for Homeless Persons

PubMed Central

Gordon, Adam J.; Montlack, Melissa L.; Freyder, Paul; Johnson, Diane; Bui, Thuy; Williams, Jennifer

2007-01-01

The Allegheny Initiative for Mental Health Integration for the Homeless (AIM-HIGH) was a 3-year urban initiative in Pennsylvania that sought to enhance integration and coordination of medical and behavioral services for homeless persons through system-, provider-, and client-level interventions. On a system level, AIM-HIGH established partnerships between several key medical and behavioral health agencies. On a provider level, AIM-HIGH conducted 5 county-wide conferences regarding homeless integration, attended by 637 attendees from 72 agencies. On a client level, 5 colocated medical and behavioral health care clinics provided care to 1986 homeless patients in 4084 encounters, generating 1917 referrals for care. For a modest investment, AIM-HIGH demonstrated that integration of medical and behavioral health services for homeless persons can occur in a large urban environment. PMID:17267708

77 FR 64816 - National Human Genome Research Institute; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-23

... sign language interpretation or other reasonable accommodations, should notify the Contact Person... relevance. Place: National Human Genome Research Institute, 5635 Fishers Lane, Terrace Level Conference Room... Genome Research Institute, 5635 Fishers Lane, Terrace Level Conference Room, Rockville, MD 20892. Contact...

Error-prone PCR mutation of Ls-EPSPS gene from Liriope spicata conferring to its enhanced glyphosate-resistance.

PubMed

Mao, Chanjuan; Xie, Hongjie; Chen, Shiguo; Valverde, Bernal E; Qiang, Sheng

2017-09-01

Liriope spicata (Thunb.) Lour has a unique LsEPSPS structure contributing to the highest-ever-recognized natural glyphosate tolerance. The transformed LsEPSPS confers increased glyphosate resistance to E. coli and A. thaliana. However, the increased glyphosate-resistance level is not high enough to be of commercial value. Therefore, LsEPSPS was subjected to error-prone PCR to screen mutant EPSPS genes capable of endowing higher resistance levels. A mutant designated as ELs-EPSPS having five mutated amino acids (37Val, 67Asn, 277Ser, 351Gly and 422Gly) was selected for its ability to confer improved resistance to glyphosate. Expression of ELs-EPSPS in recombinant E. coli BL21 (DE3) strains enhanced resistance to glyphosate in comparison to both the LsEPSPS-transformed and -untransformed controls. Furthermore, transgenic ELs-EPSPS A. thaliana was about 5.4 fold and 2-fold resistance to glyphosate compared with the wild-type and the Ls-EPSPS-transgenic plants, respectively. Therefore, the mutated ELs-EPSPS gene has potential value for has potential for the development of glyphosate-resistant crops. Copyright © 2016 Elsevier Inc. All rights reserved.

Taking your conference experience to the next level with social media

NASA Astrophysics Data System (ADS)

Burk, John

2012-03-01

I enjoyed reading Jill Tennant's "Insider Conference Tips" ; however, I think she overlooked one thing that can make conferences even more useful and strengthen the connections you make between attendees—social media. Many conferences are finding themselves completely transformed by participants live-blogging and tweeting presentations, colleagues who haven't previously met arranging "meetups" via Twitter, and, perhaps most powerfully, using social media to allow those who can't be there in person at the conference to still participate.

PREFACE: 1st International Conference on Mechanical Engineering Research 2011 (ICMER2011)

NASA Astrophysics Data System (ADS)

Abu Bakar, Rosli

2012-09-01

The year 2010 represented a significant milestone in the history of the Mechanical Engineering community with the organization of the first and second national level conferences (National Conference in Mechanical Engineering for Research, 1st and 2nd NCMER) at Universiti Malaysia Pahang on 26-27 May and 3-4 December 2010. The conferences attracted a large number of delegates from different premier academic and research institutions in the country to participate and share their research experiences at the conference. The International Conference on Mechanical Engineering Research (ICMER 2011) followed on from the first and second conferences due to good support from researchers. The ICMER 2011 is a good platform for researchers and postgraduate students to present their latest finding in research. The conference covers a wide range of topics including the internal combustion engine, machining processes, heat and mass transfer, fuel, biomechanical analysis, aerodynamic analysis, thermal comfort, computational techniques, design and simulation, automotive transmission, optimization techniques, hybrid electric vehicles, engine vibration, heat exchangers, finite element analysis, computational fluid dynamics, green energy, vehicle dynamics renewable energy, combustion, design, product development, advanced experimentation techniques, to name but a few. The international conference has helped to bridge the gap between researchers working at different institutions and in different countries to share their knowledge and has helped to motivate young scientists with their research. This has also given some clear direction for further research from the deliberations of the conference. Several people have contributed in different ways to the success of the conference. We thank the keynote speakers and all authors of the contributed papers, for the cooperation rendered to us in the publication of the CD conference proceedings. In particular, we would like to place on record our thanks to the expert reviewers who have spared their time reviewing the papers. We also highly appreciate the assistance offered by many volunteers in the preparation of the conference proceedings. All papers in ICMER 2011 have the opportunity to be published in IOP Conference Series: Materials Science and Engineering, (indexed by Scopus, Ei Compendex, Inspec), International Journal of Automotive and Mechanical Engineering (IJAME) and Journal of Mechanical Engineering and Sciences (JMES). Professor Dr Hj Rosli Abu Bakar Chairman ICMER 2011

Mother, Earth, Father Sky Symposium

NASA Technical Reports Server (NTRS)

Bowman, B.

1977-01-01

A conference was held in which minority aerospace scientists and engineers interacted with the minority community, particularly at the junior high, high school, and college levels. There were two presentations in the biological sciences, two in the physical and environmental sciences, seven in engineering and computer sciences, and nine in aerospace science and engineering. Aerospace technology careers and aerospace activities were discussed as to how they are relevant to minorities and women.

75 FR 51828 - National Human Genome Research Institute; Notice of Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-23

... space available. Individuals who plan to attend and need special assistance, such as sign language.... Place: National Institutes of Health, 5635 Fishers Lane, Terrace Level Conference Center, Bethesda, MD.../or proposals. Place: National Institutes of Health, 5635 Fishers Lane, Terrace Level Conference...

78 FR 20932 - National Institute on Alcohol Abuse and Alcoholism; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-08

... sign language interpretation or other reasonable accommodations, should notify the Contact Person... applications. Place: National Institutes of Health, 5635 Fishers Lane, Terrace Level Conference Rooms, Bethesda... council. Place: National Institutes of Health, 5635 Fishers Lane, Terrace Level Conference Rooms...

Proceedings of the 1st Army Installation Energy Security and Independence Conference

DTIC Science & Technology

2007-03-01

robustness of Transmission and Distribution system, and that pro- motes the use of demand response, CHP, and use of renewable intermit - ERDC/CERL TR...charged during low load periods. • Generation is run at optimum level during high loads. • Storage follows load and provides fast power balance during

Current Activities of the Joint Council on Economic Education.

ERIC Educational Resources Information Center

Highsmith, Robert J.

1987-01-01

Reviews current activities of the Joint Council, among them, a researcher training institute, a new K-12 economic education scope and sequence document, a junior high level test of economic knowledge, an instructional package for advanced placement classes, a textbook conference, a project to help teachers of students who work with at-risk…

Identification of QTLs conferring resistance to downy mildew in legacy cultivars of lettuce

USDA-ARS?s Scientific Manuscript database

Many cultivars of lettuce (Lactuca sativa L.), the most popular leafy vegetable, are susceptible to downy mildew disease caused by Bremia lactucae. Cultivars Iceberg and Grand Rapids that were released in 18th and 19th century, respectively, have high levels of quantitative resistance to downy milde...

Supervision that Improves Teaching: Strategies and Techniques. Second Edition

ERIC Educational Resources Information Center

Sullivan, Susan; Glanz, Jeffrey

2004-01-01

In this exciting, new edition of "Supervision That Improves Teaching," the authors have taken their reflective clinical supervision process to a new level, with the planning conference now the heart of the supervision cycle. Sullivan and Glanz have addressed the dilemmas of preserving meaningful supervision in an era of high-stakes…

Evolution of high-level resistance during low-level antibiotic exposure.

PubMed

Wistrand-Yuen, Erik; Knopp, Michael; Hjort, Karin; Koskiniemi, Sanna; Berg, Otto G; Andersson, Dan I

2018-04-23

It has become increasingly clear that low levels of antibiotics present in many environments can select for resistant bacteria, yet the evolutionary pathways for resistance development during exposure to low amounts of antibiotics remain poorly defined. Here we show that Salmonella enterica exposed to sub-MIC levels of streptomycin evolved high-level resistance via novel mechanisms that are different from those observed during lethal selections. During lethal selection only rpsL mutations are found, whereas at sub-MIC selection resistance is generated by several small-effect resistance mutations that combined confer high-level resistance via three different mechanisms: (i) alteration of the ribosomal RNA target (gidB mutations), (ii) reduction in aminoglycoside uptake (cyoB, nuoG, and trkH mutations), and (iii) induction of the aminoglycoside-modifying enzyme AadA (znuA mutations). These results demonstrate how the strength of the selective pressure influences evolutionary trajectories and that even weak selective pressures can cause evolution of high-level resistance.

Promoting social responsibility for health: health impact assessment and healthy public policy at the community level.

PubMed

Mittelmark, M B

2001-09-01

The 1997 Jakarta Declaration on Health Promotion into the 21st Century called for new responses to address the emerging threats to health. The declaration placed a high priority on promoting social responsibility for health, and it identified equity-focused health impact assessment as a high priority for action. This theme was among the foci at the 2000 Fifth Global Conference on Health Promotion held in Mexico. This paper, which is an abbreviation of a technical report prepared for the Mexico conference, advances arguments for focusing on health impact assessment at the local level. Health impact assessment identifies negative health impacts that call for policy responses, and identifies and encourages practices and policies that promote health. Health impact assessment may be highly technical and require sophisticated technology and expertise. But it can also be a simple, highly practical process, accessible to ordinary people, and one that helps a community come to grips with local circumstances that need changing for better health. To illustrate the possibilities, this paper presents a case study, the People Assessing Their Health (PATH) project from Eastern Nova Scotia, Canada. It places ordinary citizens, rather than community elites, at the very heart of local decision-making. Evidence from PATH demonstrates that low technology health impact assessment, done by and for local people, can shift thinking beyond the illness problems of individuals. It can bring into consideration, instead, how programmes and policies support or weaken community health, and illuminate a community's capacity to improve local circumstances for better health. This stands in contrast to evidence that highly technological approaches to community-level health impact assessment can be self-defeating. Further development of simple, people-centred, low technology approaches to health impact assessment at the local level is called for.

PREFACE: 23rd International Conference on High Pressure Science and Technology (AIRAPT-23)

NASA Astrophysics Data System (ADS)

Gupta, Satish C.

2012-07-01

The 23rd AIRAPT International Conference on High Pressure Science and Technology was held at Bhabha Atomic Research Centre, Mumbai, from 25-30 September 2011. This conference is part of the series of AIRAPT International Conferences which are held biennially. AIRAPT is an acronym for the French title which translates as 'International Association for the Advancement of High Pressure Science and Technology'. This was the second time the AIRAPT Conference was organized in India. The first was held 20 years ago at the National Aeronautical Laboratory, Bangalore in 1991. The 23rd Conference covered many important topics in the area of both static and dynamic high pressures including theoretical and experimental investigations on the response of materials under high pressures, new developments using neutron and synchrotron sources, investigations on superconductivity under high pressure, studies of geophysical and planetary sciences, biosciences, and the synthesis of new materials. The conference program included Bridgman award lecture, Jemieson award lecture, seven plenary talks, 85 invited talks, 83 oral presentations and about 195 posters. In all there were 372 presentations. 285 scientists from 19 countries participated in the conference. The countries represented included Austria, Canada, China, Estonia, France, Germany, India, Israel, Italy, Japan, Nepal, New Zealand, Poland, Russia, South Korea, Spain, Sweden, Switzerland, Turkey, UK, Ukraine and USA. Many new developments were presented, for example, measurement techniques using the new generation synchrotron sources, more powerful neutron sources and much brighter laser sources; integration of gas-gun with synchrotron source; the achievement of multi-megabar pressures in shock-less dynamic compressions; and capabilities to synthesize centimeter size diamonds with better quality. All these developments have opened up new opportunities for understanding the physics of materials under high pressures. I would like to thank all those who have made valuable contributions to the success of the conference, which include the members of the AIRAPT executive committee, the International Advisory Committee and National Advisory Committee, the plenary speakers, invited speakers, the chairmen of various sessions, all the participants, and the authors of the papers in this volume. All the papers accepted for the proceedings have been reviewed by two independent referees. I am extremely thankful to all the anonymous referees, who have spent their valuable time to ensure the quality of the papers of this volume. I wish to express my gratitude to the members of the Local Organizing Committee for their help and hard work for the success of the conference. Finally, I convey my special thanks to Dr T C Kaushik and Dr K D Joshi, who worked tirelessly and enthusiastically towards making this conference a success. I am confident that this volume of the Conference proceedings will provide an excellent source of information on the current trends in the field of High Pressure Science and Technology. Satish C Gupta Conference Chairman 25-30 September 2011 Conference logo Conference photograph

78 FR 47715 - National Human Genome Research Institute; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-06

... space available. Individuals who plan to attend and need special assistance, such as sign language...: National Institutes of Health, Terrace Level Conference Room, 5635 Fishers Lane, Rockville, MD 20892. Open... Institutes of Health, Terrace Level Conference Room, 5635 Fishers Lane, Rockville, MD 20892. Closed...

77 FR 2735 - National Human Genome Research Institute; Notice of Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-19

... space available. Individuals who plan to attend and need special assistance, such as sign language... relevance. Place: National Institutes of Health, 5635 Fishers Lane, Terrace Level Conference Room, Rockville... applications and/or proposals. Place: National Institutes of Health, 5635 Fishers Lane Terrace Level Conference...

10th international conference on high-occupancy vehicle systems : compendium of technical papers

DOT National Transportation Integrated Search

2001-08-01

This report provides the technical papers submitted as part of the 10th International High-Occupancy Vehicle (HOV) Systems Conference held in Dallas, Texas on August 27-30, 2000. The Conference was sponsored by the Transportation Research Board (TRB)...

Elevated catalase expression in a fungal pathogen is a double-edged sword of iron

PubMed Central

Belmonte, Rodrigo; Budge, Susan; Lopez Garcia, Angela; Lee, Keunsook K.; Bebes, Attila; Quinn, Janet

2017-01-01

Most fungal pathogens of humans display robust protective oxidative stress responses that contribute to their pathogenicity. The induction of enzymes that detoxify reactive oxygen species (ROS) is an essential component of these responses. We showed previously that ectopic expression of the heme-containing catalase enzyme in Candida albicans enhances resistance to oxidative stress, combinatorial oxidative plus cationic stress, and phagocytic killing. Clearly ectopic catalase expression confers fitness advantages in the presence of stress, and therefore in this study we tested whether it enhances fitness in the absence of stress. We addressed this using a set of congenic barcoded C. albicans strains that include doxycycline-conditional tetON-CAT1 expressors. We show that high basal catalase levels, rather than CAT1 induction following stress imposition, reduce ROS accumulation and cell death, thereby promoting resistance to acute peroxide or combinatorial stress. This conclusion is reinforced by our analyses of phenotypically diverse clinical isolates and the impact of stochastic variation in catalase expression upon stress resistance in genetically homogeneous C. albicans populations. Accordingly, cat1Δ cells are more sensitive to neutrophil killing. However, we find that catalase inactivation does not attenuate C. albicans virulence in mouse or invertebrate models of systemic candidiasis. Furthermore, our direct comparisons of fitness in vitro using isogenic barcoded CAT1, cat1Δ and tetON-CAT1 strains show that, while ectopic catalase expression confers a fitness advantage during peroxide stress, it confers a fitness defect in the absence of stress. This fitness defect is suppressed by iron supplementation. Also high basal catalase levels induce key iron assimilatory functions (CFL5, FET3, FRP1, FTR1). We conclude that while high basal catalase levels enhance peroxide stress resistance, they place pressure on iron homeostasis through an elevated cellular demand for iron, thereby reducing the fitness of C. albicans in iron-limiting tissues within the host. PMID:28542620

Elevated catalase expression in a fungal pathogen is a double-edged sword of iron.

PubMed

Pradhan, Arnab; Herrero-de-Dios, Carmen; Belmonte, Rodrigo; Budge, Susan; Lopez Garcia, Angela; Kolmogorova, Aljona; Lee, Keunsook K; Martin, Brennan D; Ribeiro, Antonio; Bebes, Attila; Yuecel, Raif; Gow, Neil A R; Munro, Carol A; MacCallum, Donna M; Quinn, Janet; Brown, Alistair J P

2017-05-01

Most fungal pathogens of humans display robust protective oxidative stress responses that contribute to their pathogenicity. The induction of enzymes that detoxify reactive oxygen species (ROS) is an essential component of these responses. We showed previously that ectopic expression of the heme-containing catalase enzyme in Candida albicans enhances resistance to oxidative stress, combinatorial oxidative plus cationic stress, and phagocytic killing. Clearly ectopic catalase expression confers fitness advantages in the presence of stress, and therefore in this study we tested whether it enhances fitness in the absence of stress. We addressed this using a set of congenic barcoded C. albicans strains that include doxycycline-conditional tetON-CAT1 expressors. We show that high basal catalase levels, rather than CAT1 induction following stress imposition, reduce ROS accumulation and cell death, thereby promoting resistance to acute peroxide or combinatorial stress. This conclusion is reinforced by our analyses of phenotypically diverse clinical isolates and the impact of stochastic variation in catalase expression upon stress resistance in genetically homogeneous C. albicans populations. Accordingly, cat1Δ cells are more sensitive to neutrophil killing. However, we find that catalase inactivation does not attenuate C. albicans virulence in mouse or invertebrate models of systemic candidiasis. Furthermore, our direct comparisons of fitness in vitro using isogenic barcoded CAT1, cat1Δ and tetON-CAT1 strains show that, while ectopic catalase expression confers a fitness advantage during peroxide stress, it confers a fitness defect in the absence of stress. This fitness defect is suppressed by iron supplementation. Also high basal catalase levels induce key iron assimilatory functions (CFL5, FET3, FRP1, FTR1). We conclude that while high basal catalase levels enhance peroxide stress resistance, they place pressure on iron homeostasis through an elevated cellular demand for iron, thereby reducing the fitness of C. albicans in iron-limiting tissues within the host.

Antibody treatment against pulmonary exposure to abrin confers significantly higher levels of protection than treatment against ricin intoxication.

PubMed

Sabo, Tamar; Gal, Yoav; Elhanany, Eitan; Sapoznikov, Anita; Falach, Reut; Mazor, Ohad; Kronman, Chanoch

2015-09-02

Abrin, a potent plant-derived toxin bearing strong resemblance to ricin, irreversibly inactivates ribosomes by site-specific depurination, thereby precipitating cessation of protein synthesis in cells. Due to its high availability and ease of preparation, abrin is considered a biological threat, especially in context of bioterror warfare. To date, there is no established therapeutic countermeasure against abrin intoxication. In the present study, we examined the progress of pulmonary abrin intoxication in mice, evaluated the protective effect of antibody-based post-exposure therapy, and compared these findings to those observed for ricin intoxication and therapy. Salient features of abrin intoxication were found to be similar to those of ricin and include massive recruitment of neutrophils to the lungs, high levels of pro-inflammatory markers in the bronchoalveolar lavage fluid and damage of the alveolar-capillary barrier. In contrast, the protective effect of anti-abrin antibody treatment was found to differ significantly from that of anti-ricin treatment. While anti-ricin treatment efficiency was quite limited even at 24h post-exposure (34% protection), administration of polyclonal anti-abrin antibodies even as late as 72h post-exposure, conferred exceedingly high-level protection (>70%). While both anti-toxin antibody treatments caused neutrophil and macrophage levels in the lungs to revert to normal, only anti-abrin treatment brought about a significant decline in the pulmonary levels of the pro-inflammatory cytokine IL-6. The differential ability of the anti-toxin treatments to dampen inflammation caused by the two similar toxins, abrin and ricin, could explain the radically different levels of protection achieved following antibody treatment. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Lifelong Learning Research Conference Proceedings (4th, College Park, Maryland, February 12-13, 1982).

ERIC Educational Resources Information Center

Whaples, Gene C., Comp.; Rivera, William M., Comp.

These conference proceedings contain 55 papers and symposia presented at the conference whose focus was on nonformal adult education. Papers deal with adult/continuing education concerns such as participatory research, ABLE (Adult Basic Level Education) parenting, army basic skills educational development, learning contracts, volunteerism,…

Doesn't He Have Beautiful Blue Eyes? Tips for a Successful Parent-Teacher Conference.

ERIC Educational Resources Information Center

Strudler, Ruth

1993-01-01

Tips for successful parent-teacher conferences concerning children with special needs focus on preventing a conflict cycle and developing a cooperation cycle. Specific suggestions to reduce stress levels and involve parents positively are offered for preconference behaviors, conference behaviors, and postconference behaviors. (DB)

Inter Association Child Care Conference. Conference Proceedings 1979.

ERIC Educational Resources Information Center

Austin, David, Ed.

This publication of the proceedings of the Inter Association Child Care Conference includes a debate for and against professionalization in the field of child care. A section on meeting the treatment needs of children through educational preparation of child care practitioners discusses background factors, levels of education for practitioners,…

Facilities Planning Conference for Community-Junior College State-Level Personnel.

ERIC Educational Resources Information Center

Florida Univ., Gainesville. Inst. of Higher Education.

This report on planning and developing facilities for community-junior colleges includes papers presented at a conference for state-level facility planners. The meeting covered the following areas: (1) development of physical facilities responsive to educational programs and community needs; (2) efficient use of existing facilities through…

PREFACE: International Conference on Computing in High Energy and Nuclear Physics (CHEP'07)

NASA Astrophysics Data System (ADS)

Sobie, Randall; Tafirout, Reda; Thomson, Jana

2007-07-01

The 2007 International Conference on Computing in High Energy and Nuclear Physics (CHEP) was held on 2-7 September 2007 in Victoria, British Columbia, Canada. CHEP is a major series of international conferences for physicists and computing professionals from the High Energy and Nuclear Physics community, Computer Science and Information Technology. The CHEP conference provides an international forum to exchange information on computing experience and needs for the community, and to review recent, ongoing, and future activities. The CHEP'07 conference had close to 500 attendees with a program that included plenary sessions of invited oral presentations, a number of parallel sessions comprising oral and poster presentations, and an industrial exhibition. Conference tracks covered topics in Online Computing, Event Processing, Software Components, Tools and Databases, Software Tools and Information Systems, Computing Facilities, Production Grids and Networking, Grid Middleware and Tools, Distributed Data Analysis and Information Management and Collaborative Tools. The conference included a successful whale-watching excursion involving over 200 participants and a banquet at the Royal British Columbia Museum. The next CHEP conference will be held in Prague in March 2009. We would like thank the sponsors of the conference and the staff at the TRIUMF Laboratory and the University of Victoria who made the CHEP'07 a success. Randall Sobie and Reda Tafirout CHEP'07 Conference Chairs

GE STEM Teacher's Conference

NASA Image and Video Library

2017-07-13

Teachers participate in the Rocketry Engineering Design Challenge during the 2017 GE Foundation High School STEM Integration Conference at the Center for Space Education at NASA's Kennedy Space Center. High school teachers from across the country took part in the week-long conference, which is designed to explore effective ways for teachers, schools and districts from across the country to integrate STEM throughout the curriculum. The conference is a partnership between GE Foundation and the National Science Teachers Association.

The S230R Integrase Substitution Associated with Viral Rebound during DTG Monotherapy Confers Low Levels INSTI Drug Resistance.

PubMed

Pham, Hanh T; Labrie, Lydia; Wijting, Ingeborg E A; Hassounah, Said; Lok, Ka Yee; Portna, Inna; Goring, Mark; Han, Yingshan; Lungu, Cynthia; van der Ende, Marchina E; Brenner, Bluma G; Boucher, Charles A; Rijnders, Bart J A; van Kampen, Jeroen J A; Mesplède, Thibault; Wainberg, Mark A

2018-03-29

Dolutegravir (DTG) is an integrase strand-transfer inhibitor (INSTI) used for treatment of HIV-infected individuals. Due to its high genetic barrier to resistance, DTG has been clinically investigated as maintenance monotherapy to maintain viral suppression and to reduce complication and healthcare costs. Our study aims to explain the underlying mechanism related to the emergence of a S230R substitution in patients who experienced virological failure while using DTG monotherapy. We evaluated the effect of S230R substitution in regard to IN enzyme activity, viral infectivity, replicative capacity and susceptibility to different INSTIs by biochemical and cell-based assays. S230R substitution conferred 63% reduction in enzyme efficiency. The S230R virus was 1.29-fold less infectious than wildtype (WT), but could replicate in PM1 cells without significant delay. Resistance levels against DTG, CAB, RAL and EVG in tissue culture were 3.85-, 3.72-, 1.52-, and 1.21-fold, respectively. Our data indicate that the S230R substitution is comparable to the previously reported R263K in some respects. Virological failure under DTG monotherapy can occur through the development of such S230R or R263K mutations without the need for high levels DTG resistance.

High Productivity Computing Systems and Competitiveness Initiative

DTIC Science & Technology

2007-07-01

planning committee for the annual, international Supercomputing Conference in 2004 and 2005. This is the leading HPC industry conference in the world. It...sector partnerships. Partnerships will form a key part of discussions at the 2nd High Performance Computing Users Conference, planned for July 13, 2005...other things an interagency roadmap for high-end computing core technologies and an accessibility improvement plan . Improving HPC Education and

Teachers Use Tools and Strategies to Engage Students in Grade-Level Assignments

ERIC Educational Resources Information Center

Southern Regional Education Board (SREB), 2013

2013-01-01

This newsletter of best practices in implementing the High Schools That Work (HSTW), Making Middle Grades Work (MMGW) and Technology Centers That Work (TCTW) school improvement models is based on presentations at the 27th Annual HSTW Staff Development Conference in Charlotte, North Carolina, in the summer of 2013. The newsletter is divided up into…

Resistance to downy mildew in lettuce ‘La Brillante’ is conferred by dm50 gene and multiple QTL

USDA-ARS?s Scientific Manuscript database

Many cultivars of lettuce (Lactuca sativa L.) are susceptible to downy mildew, a nearly globally ubiquitous disease caused by Bremia lactucae. We previously determined that Batavia type cultivar La Brillante has a high level of field resistance to the disease in California. Testing of a mapping popu...

What Friends Are For: Collaborative Intelligence Analysis and Search

DTIC Science & Technology

2014-06-01

14. SUBJECT TERMS Intelligence Community, information retrieval, recommender systems , search engines, social networks, user profiling, Lucene...improvements over existing search systems . The improvements are shown to be robust to high levels of human error and low similarity between users ...precision NOLH nearly orthogonal Latin hypercubes P@ precision at documents RS recommender systems TREC Text REtrieval Conference USM user

Final Report of Cambridge Conference on School Mathematics, January 1962 - August 1970.

ERIC Educational Resources Information Center

Cambridge Conference on School Mathematics, Newton, MA.

The Cambridge Conference on School Mathematics (CCSM) was an association of prominent mathematicians who had a concern for mathematics education at school level, from kindergarten through grade twelve. These mathematicians organized three main conferences in three areas of mathematics education, and have carried on activities related to the…

Using a Conference Workshop Setting to Engage Mathematics Teachers in Culturally Relevant Pedagogy

ERIC Educational Resources Information Center

Timmons-Brown, Stephanie; Warner, Catharine

2016-01-01

In this article, the authors explore using a conference workshop setting to engage mathematics teachers, who serve largely underserved student populations, in culturally relevant pedagogy (CRP). The conference workshop encouraged the exchange of information among teachers of similar grade levels and classroom contexts. The authors' analysis of the…

A School-Wide Approach to Student-Led Conferences: A Practitioner's Guide.

ERIC Educational Resources Information Center

Kinney, Patti; Munroe, Mary Beth; Sessions, Pam

Noting that the benefits of student-led conferences align well with practices recognized as developmentally appropriate for the middle school years, this book provides a step-by-step guide to implementing student-led conferences at the middle school level. The chapters are: (1) "Setting the Stage," presenting the rationale for student-led…

Emphasis: Technical Education. Conference Report (St. Louis, Mo., May 12-14, 1966).

ERIC Educational Resources Information Center

American Association of Junior Colleges, Washington, DC.

The purpose of this conference was to bring expertise in the field of technical education to bear upon the identification and resolution of problems inhibiting the expansion of programs at the junior college level. Sixty-four participants were involved. The conference focused upon the relationships of technical education to: society, college…

News Quantum physics: German Physical Society spring meeting Journal access: American Physical Society's online journals will be available for free in all US high schools Award: High-school physics teacher receives American award for excellence Teacher training: Fobinet offers coordination of teacher-training activities Astronomy: Astronomy fans see stars at Astrofest Conference: Delegates enjoy the workshops and activities at CPD conference Forthcoming events

NASA Astrophysics Data System (ADS)

2011-05-01

Quantum physics: German Physical Society spring meeting Journal access: American Physical Society's online journals will be available for free in all US high schools Award: High-school physics teacher receives American award for excellence Teacher training: Fobinet offers coordination of teacher-training activities Astronomy: Astronomy fans see stars at Astrofest Conference: Delegates enjoy the workshops and activities at CPD conference Forthcoming events

Gender differences in conference presentations: a consequence of self-selection?

PubMed Central

Fanson, Kerry V.; Lanfear, Rob; Symonds, Matthew R.E.; Higgie, Megan

2014-01-01

Women continue to be under-represented in the sciences, with their representation declining at each progressive academic level. These differences persist despite long-running policies to ameliorate gender inequity. We compared gender differences in exposure and visibility at an evolutionary biology conference for attendees at two different academic levels: student and post-PhD academic. Despite there being almost exactly a 1:1 ratio of women and men attending the conference, we found that when considering only those who presented talks, women spoke for far less time than men of an equivalent academic level: on average student women presented for 23% less time than student men, and academic women presented for 17% less time than academic men. We conducted more detailed analyses to tease apart whether this gender difference was caused by decisions made by the attendees or through bias in evaluation of the abstracts. At both academic levels, women and men were equally likely to request a presentation. However, women were more likely than men to prefer a short talk, regardless of academic level. We discuss potential underlying reasons for this gender bias, and provide recommendations to avoid similar gender biases at future conferences. PMID:25346879

Creatinine metabolite, HMH (5-hydroxy-1-methylhydantoin; NZ-419), modulates bradykinin-induced changes in vascular smooth muscle cells.

PubMed

Ienaga, Kazuharu; Sohn, Mimi; Naiki, Mitsuru; Jaffa, Ayad A

2014-06-01

A creatinine metabolite, 5-hydroxy-1-methylhydantoin (HMH: NZ-419), a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. In the current study, we demonstrate that HMH modulates the effects of glucose and bradykinin (BK) in vascular smooth muscle cell (VSMC). HMH a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. HMH inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that HMH may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.

Proceedings of the 13th Space Photovoltaic Research and Technology Conference (SPRAT 13)

NASA Technical Reports Server (NTRS)

1994-01-01

The Thirteenth Space Photovoltaic Research and Technology (SPRAT) Conference included 38 technical papers, 6 program reviews and 5 workshop discussions. The effects of shrinking research and development budgets were evident in the focus and tone of this SPRAT. Most attendees appeared to be oriented toward near term, system oriented projects and fewer were involved in long term, high risk research. It was generally agreed that space power requirements would continue to move toward smaller (less than 2kW) power levels. Most future applications are believed to be in traditional orbits (LEO, GEO) although interesting opportunities may be found in high radiation, mid-altitude orbits useful for global communication networks. New solar cell devices and materials will be difficult to introduce unless they are mission enabling, or offer significant cost and/or performance benefits. Many factors influence the selection of type of array.

Guide for Planning a High School Environmental Action Conference.

ERIC Educational Resources Information Center

Wanless, Angie, Comp.; And Others

The purpose of this manual is to provide guidelines and suggestions for people organizing an environmental action conference for high school students. The format and planning suggestions are based on the methods used for a conference organized by the Wisconsin Center for Environmental Education in 1991. The bulk of the manual provides structure…

PREFACE: 3rd International Conference on Science & Engineering in Mathematics, Chemistry and Physics 2015 (ScieTech 2015)

NASA Astrophysics Data System (ADS)

Gaol, F. L.

2015-06-01

The 3rd International Conference on Science & Engineering in Mathematics, Chemistry and Physics 2015 (ScieTech 2015), was held at The Westin Resort Nusa Dua, Bali on 31 January - 1 February 2015. The ScieTech 2015 conference is aimed to bring together researchers, engineers and scientists from around the world. ScieTech 2015 is placed on promoting interaction between the theoretical, experimental, and applied communities, so that a high level exchange is achieved in new and emerging areas within mathematics, chemistry and physics. As we already know that science and technology have brought tremendous benefits for human civilization. People are becoming healthier, wealthier, better educated, more peaceful, increasingly connected, and living longer. Of course, science and technology provide many answers to global challenges, but we will face more complex problems in the next decade due to increasing world population, limitation of energy, and climate change. Therefore, researchers should be more active in conducting research that enables collaboration between one and the others. Interdisciplinary cooperation is absolutely necessary in order to create a smart system for solving the global problems. We need a global and general long-term view of the future with long-range goals for solving complex problems in next decade. Therefore the conference was held to be a forum for researchers from different disciplines to start collaborating and conducting research that provides a solution to the global issues. The theme of ScieTech 2015 was ''The interdisciplinary Application between Mathematics, Chemistry and Physics to enhance the Quality of Life''. We would like to express our sincere gratitude to all in the Technical Program Committee who have reviewed the papers and developed a very interesting conference program as well as the invited and plenary speakers. This year, we received 197 papers and after rigorous review, 59 papers were accepted. The participants came from 19 countries, and there were six paralell sessions and four keynote speakers. It is an honour to present this volume of Journal of Physics: Conference Series (JPCS) and we deeply thank the authors for their enthusiastic and high-grade contributions. Finally, we would like to thank the conference chairmen, members of the steering committee, the organizing committee, the organizing secretariat and the financial support from the conference sponsors that allowed the success of ScieTech 2015.

PREFACE: International Workshop on Discovery Physics at the LHC (Kruger2014)

NASA Astrophysics Data System (ADS)

Cleymans, Jean

2015-06-01

The third biannual conference on 'Discovery Physics at the LHC' was held on December 1-6 2014 at the Kruger Gate Hotel in South Africa. Over 100 participants attended from Austria, Australia, Belgium, Brazil, Canada, China, the Czech Republic, France, Germany, Italy, the Netherlands, Norway, Poland, South Africa, Switzerland, the UK and the USA. The latest results from the Large Hadron Collider as well the latest theoretical insights were presented. With the majestic Kruger National Park in the background this led to a very stimulating conference with many exchanges taking place. The proceedings reflect the high level of the conference. The financial contributions from the SA-CERN programme, the UCT-CERN Research Centre, the University of Johannesburg, the University of the Witwatersrand and iThemba L.A.B.S. are gratefully acknowledged. Local Organizing Committee: Z. Buthelezi J. Cleymans (chair) S. H. Connell A. S. Cornell T. Dietel S. Förtsch N. Haasbroek A. Hamilton W. A. Horowitz B. Mellado Z. Z. Vilakazi S. Yacoob

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

The papers in this document comprise the proceedings of the Department of Energy's Twelfth Annual Low-Level Radioactive Waste Management Conference, which was held in Chicago, Illinois, on August 28 and 29, 1990. General subjects addressed during the conference included: mixed waste, low-level radioactive waste tracking and transportation, public involvement, performance assessment, waste stabilization, financial assurance, waste minimization, licensing and environmental documentation, below-regulatory-concern waste, low-level radioactive waste temporary storage, current challenges, and challenges beyond 1990.

PREFACE: Sixth International Conference on Dissociative Recombination: Theory, Experiments and Applications

NASA Astrophysics Data System (ADS)

Wolf, Andreas; Lammich, Lutz; Schmelcher, Peter

2005-01-01

Dissociative recombination between electrons and molecular ions is an elementary reaction in electron-induced chemistry attracting strong attention across discipline boundaries, from fundamental questions of intramolecular dynamics to astrophysics, plasma science, as well as atmospheric and planetary physics. The process is explored on the level of atomic quantum dynamics both experimentally and theoretically, employing cold collisions at temperatures down to 10 Kelvin involving small molecules or also very large systems ranging up to biomolecules. Dissociative recombination (DR) and related processes, such as dissociative excitation, collisional cooling of vibrations and rotations, photodissociation via high-lying electronic states, resonant electron attachment, and electron-induced processes in large molecules and clusters, are studied by a variety of experimental methods, including stored and trapped molecular ions, plasma techniques such as stationary and flowing afterglow, and laser spectroscopic diagnostic of molecular excitations. The Sixth International Conference on Dissociative Recombination: Theory, Experiments and Applications (DR2004) was organized by the Research Group on Atomic and Molecular Physics with Stored Ions at the Max-Planck Institute for Nuclear Physics in Heidelberg, Germany, and held near Heidelberg in the town of Mosbach in July 2004. It was attended by about 90 scientists working in atomic and molecular physics, astrophysics, plasma- and biophysics. International Conferences on Dissociative Recombination and related processes were held before at Lake Louise, Alberta, Canada (1988), Saint Jacut, Brittany, France (1992), Ein Gedi, Israel (1995), Nässlingen, Stockholm Archipelago, Sweden (1999), and last within a symposium at the American Chemical Society meeting in Chicago, USA (2001). The presentations of this conference document a strong development of theoretical ideas towards the understanding of DR in particular in polyatomic systems. Strong attention was given to the elementary triatomic benchmark system H3+, characterized by ambitious, complementary experimental projects. Interaction of experiment and theory improves in particular the understanding of non-adiabatic molecular interactions involving electronic continuum states. New experimental techniques focus on a detailed control of the internal molecular excitation on the level of single quantum states, which gives increasing importance to laser interactions and ion storage at cryogenic temperatures. Apart from its place in the series of "DR conferences", this meeting is also the final assembly of the EU Research Training Network "Electron Transfer Reactions" (ETR) which in the period from 2000 to 2004 helped to establish many invaluable links between 15 experimental and theoretical institutes active in the field of DR and related processes. We express our gratitude to the EU for the support through the Research Training Network Programme, which has made possible the attendance of many students and young researchers. Furthermore, generous financial support for this conference was provided by the Max-Planck Institute for Nuclear Physics in Heidelberg. The efficient support of the conference center "Alte Mälzerei", operated by the city of Mosbach, is gratefully acknowledged. Finally we warmly thank the staff and the students of the Max-Planck Institute for Nuclear Physics for the dedicated help during the conference.

GE STEM Teacher's Conference

NASA Image and Video Library

2017-07-13

Teachers prepare to demonstrate the projects they built for the Rocketry Engineering Design Challenge during the 2017 GE Foundation High School STEM Integration Conference at the Center for Space Education at NASA's Kennedy Space Center. High school teachers from across the country took part in the week-long conference, which is designed to explore effective ways for teachers, schools and districts from across the country to integrate STEM throughout the curriculum. The conference is a partnership between GE Foundation and the National Science Teachers Association.

Development and characterization of mutant winter wheat (Triticum aestivum L.) accessions resistant to the herbicide quizalofop.

PubMed

Ostlie, Michael; Haley, Scott D; Anderson, Victoria; Shaner, Dale; Manmathan, Harish; Beil, Craig; Westra, Phillip

2015-02-01

New herbicide resistance traits in wheat were produced through the use of induced mutagenesis. While herbicide-resistant crops have become common in many agricultural systems, wheat has seen few introductions of herbicide resistance traits. A population of Hatcher winter wheat treated with ethyl methanesulfonate was screened with quizalofop to identify herbicide-resistant plants. Initial testing identified plants that survived multiple quizalofop applications. A series of experiments were designed to characterize this trait. In greenhouse studies the mutants exhibited high levels of quizalofop resistance compared to non-mutant wheat. Sequencing ACC1 revealed a novel missense mutation causing an alanine to valine change at position 2004 (Alopecurus myosuroides reference sequence). Plants carrying single mutations in wheat's three genomes (A, B, D) were identified. Acetyl co-enzyme A carboxylase in resistant plants was 4- to 10-fold more tolerant to quizalofop. Populations of segregating backcross progenies were developed by crossing each of the three individual mutants with wild-type wheat. Experiments conducted with these populations confirmed largely normal segregation, with each mutant allele conferring an additive level of resistance. Further tests showed that the A genome mutation conferred the greatest resistance and the B genome mutation conferred the least resistance to quizalofop. The non-transgenic herbicide resistance trait identified will enhance weed control strategies in wheat.

Linking information and people in a social system for academic conferences

NASA Astrophysics Data System (ADS)

Brusilovsky, Peter; Oh, Jung Sun; López, Claudia; Parra, Denis; Jeng, Wei

2017-04-01

This paper investigates the feasibility of maintaining a social information system to support attendees at an academic conference. The main challenge of this work was to create an infrastructure where users' social activities, such as bookmarking, tagging, and social linking could be used to enhance user navigation and maximize the users' ability to locate two important types of information in conference settings: presentations to attend and attendees to meet. We developed Conference Navigator 3, a social conference support system that integrates a conference schedule planner with a social linking service. We examined its potential and functions in the context of a medium-scale academic conference. In this paper, we present the design of the system's socially enabled features and report the results of a conference-based study. Our study demonstrates the feasibility of social information systems for supporting academic conferences. Despite the low number of potential users and the short timeframe in which conferences took place, the usage of the system was high enough to provide sufficient data for social mechanisms. The study shows that most critical social features were highly appreciated and used, and provides direction for further research.

Proceedings of the IFIP WG 11.3 Working Conference on Database Security (6th) Held in Vancouver, British Columbia on 19-22 August 1992.

DTIC Science & Technology

1992-01-01

multiversioning scheme for this purpose was presented in [9]. The scheme guarantees that high level methods would read down object states at lower levels that...order given by fork-stamp, and terminated writing versions with timestamp WStamp. Such a history is needed to implement the multiversioning scheme...recovery protocol for multiversion schedulers and show that this protocol is both correct and secure. The behavior of the recovery protocol depends

High performance systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Vigil, M.B.

1995-03-01

This document provides a written compilation of the presentations and viewgraphs from the 1994 Conference on High Speed Computing given at the High Speed Computing Conference, {open_quotes}High Performance Systems,{close_quotes} held at Gleneden Beach, Oregon, on April 18 through 21, 1994.

Making Conferences Human Places of Learning

ERIC Educational Resources Information Center

Kenny, Michael

2014-01-01

Open Space Technology is a cumbersome name for a participative conference model that enables dynamic inclusive engagement and challenges traditional, highly structured hierarchical conference formats. Based on self-organising systems, (Wenger, 1998) Open Space Technology conferences have an open process, start with no agenda and empower the most…

Proceedings: National Conference on Bilingual Education (Austin, Texas, April 14-15, 1972).

ERIC Educational Resources Information Center

Dissemination and Assessment Center for Bilingual Education, Austin, TX.

Goals of the National Conference on Bilingual Education, held on April 14-15, 1972 in Austin, Texas, were to emphasize bilingual education interaction at the national level using outstanding consultants from throughout the United States and to exchange ideas among educators in existing programs. The conference was also organized to give bilingual…

Earned Degrees Conferred: 1969-70 Summary Data.

ERIC Educational Resources Information Center

Hooper, Mary Evans

This document presents a report of earned degrees conferred by institutions of higher education in the United States in 1969-1970. Some of the highlights of the report include: (1) 1,072,581 degrees were conferred at the bachelor's and higher levels at 1,617 institutions; (2) publically controlled institutions awarded 65% of all degrees; (3)…

Reports from the International Conference on Education, 1977. Rapports de la Conference internationale de l'education, 1977.

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Paris (France).

This dual-language catalog contains abstracts of 188 documents prepared for the 1977 International Conference on Education. The documents describe educational policies toward development, major trends in education, and the problem of information at the national and international levels posed by the improvement of educational systems. Abstracts are…

Selected Papers from the 1982 Conference "New York Writes: Kindergarten through College" (New York, New York, April 3, 1982).

ERIC Educational Resources Information Center

Kwalick, Barry, Ed.; And Others

Presenting sound instructional strategies and writing theories, these proceedings of a conference held at Marymount Manhattan College address the needs of writing teachers at all educational levels. Following an introduction outlining the conference and the "New York Writes" project, the keynote address discusses the renewed interest in…

Architecture for Change: Information as Foundation. 1998 AAHE Assessment Conference (Cincinnati, OH, June 13-17, 1998).

ERIC Educational Resources Information Center

Miller, Margaret A.; Ehrmann, Stephen C.; Rohan, Sue; Eaton, Judith S.; Mac Gregor, Jean; Wergin, Jon F.; Alberts, Bruce

The seven speeches in these proceedings were presented at the 1998 American Association for Higher Education conference on assessment. "Blueprints" sets out the architecture of the conference with four "strands," each focusing on one level of information. The first is assessment of pedagogies in the classroom, on campus, and…

PREFACE: 4th Global Conference on Materials Science and Engineering (CMSE 2015)

NASA Astrophysics Data System (ADS)

Ruda, H. E.; Khotsianovsky, A.

2015-12-01

IOP Conference Series: Materials Science and Engineering is publishing a volume of conference proceedings that contains a selection of papers presented at the 4th Global Conference on Materials Science and Engineering (CMSE 2015), which is an annual event that started in 2012. CMSE 2015, technically supported by the Institute of Applied Physics and Materials Engineering of University of Macau, organized by Wuhan Advance Materials Society, was successfully held at the University of Macau-new campus located on Hengqin Island from August 3rd-6th, 2015. It aims to bring together leading academic scientists, researchers and scholars to exchange and share their experience and research results on all aspects of Materials Science and Engineering, and to discuss the practical challenges encountered and the solutions adopted. Macau, one of the two special administrative regions of the People's Republic of China, where East meets West, turned out to be an ideal meeting place for domestic and overseas participants of this annual international conference. The conference program included keynote presentations, special sessions, oral and poster contributions. From several hundred submissions, 52 of the most promising and mainstream, IOP-relevant, contributions were included in this volume. The submissions present original ideas or results of general significance, supported by clear reasoning, compelling evidence and methods, theories and practices relevant to the research. The authors state clearly the problems and the significance of their research to theory and practice. Being a successful conference, this event gathered more than 200 qualified and high-level researchers and experts from over 40 countries, including 10 keynote speakers from 6 countries, which created a good platform for worldwide researchers and engineers to enjoy the academic communication. Taking advantage of this opportunity, we would like to thank all participants of this conference, and particularly the authors of all accepted papers for their high quality and fruitful contributions. Special thanks are due to all reviewers for their careful critical reading of the manuscripts and useful comments and suggestions. We do hope that this volume will be beneficial for readers to their future research endeavours and careers. We also gratefully acknowledge tremendous efforts and dedication of many individuals, especially CMSE Conference Secretary Ms. Liu Qin, Editor Anete Ashton and all the Editorial Board members in IOP Publishing for their support in producing the proceedings of this event. Guest Editors: Prof. Harry E. Ruda University of Toronto, Canada Dr. Alexander Khotsianovsky Pisarenko Institute of Problems of Strength of the National Academy of Sciences of Ukraine, Ukraine

PREFACE: INERA Conference 2015: Light in Nanoscience and Nanotechnology (LNN 2015)

NASA Astrophysics Data System (ADS)

Nesheva, D.; Chamati, H.; Genova, J.; Gesheva, K.; Ivanova, T.; Szekeres, A.

2016-02-01

We are pleased to introduce the Proceedings of the Conference ''Light in Nanoscience and Nanotechnology 2015'' (LNN 2015) organized by the Institute of Solid State Physics, Bulgarian Academy of Sciences in the frames of the INERA Project ''Research and Innovation Capacity Strengthening of ISSP-BAS in Multifunctional Nanostructures'' REGPOT-2012-2013-1 NMP. The LNN 2015 Conference was dedicated to the ''International year of light - 2015''. The Conference took place from 20th to 22nd of October in the beautiful spa resort Hissar, situated 140 km away from Sofia, close to the famous Valley of Roses, amidst a real abundance of curative mineral waters. The resort has an old history - even the ancient Romans knew well the curative properties of the water. Today the town has more than 4 km of Roman as well as architectural remains. During the age of the Roman Empire, the town, called Augusta, was a wealthy healing center with Emperors' palaces, wide stone streets, marble baths, statues of Roman Gods and exuberant vegetation. Participants from 13 different countries delivered 22 invited lectures, 17 oral and 46 poster presentations, contributing in 8 different topics. Papers submitted to the Proceedings were refereed according to the standards of the Journal of Physics: Conference Series and the accepted ones illustrate the diversity and the high level of the contributions. The Conference gave a good opportunity for interesting discussions and exchange of ideas between the participants. Not least, a significant factor for the success of the LNN 2015 was the social program, the relaxing spa facilities and the guided tour through the Roman remains of the town. The proceedings of conferences and workshops organized in the frames of INERA Project are regularly published by the Journal of Physics: Conference Series. We are grateful to the Journal's staff for providing us this opportunity.

PREFACE: 7th EEIGM International Conference on Advanced Materials Research

NASA Astrophysics Data System (ADS)

Joffe, Roberts

2013-12-01

The 7th EEIGM Conference on Advanced Materials Research (AMR 2013) was held at Luleå University of Technology on the 21-22 March 2013 in Luleå, SWEDEN. This conference is intended as a meeting place for researchers involved in the EEIGM programme, in the 'Erasmus Mundus' Advanced Materials Science and Engineering Master programme (AMASE) and the 'Erasmus Mundus' Doctoral Programme in Materials Science and Engineering (DocMASE). This is great opportunity to present their on-going research in the various fields of Materials Science and Engineering, exchange ideas, strengthen co-operation as well as establish new contacts. More than 60 participants representing six countries attended the meeting, in total 26 oral talks and 19 posters were presented during two days. This issue of IOP Conference Series: Materials Science and Engineering presents a selection of articles from EEIGM-7 conference. Following tradition from previous EEIGM conferences, it represents the interdisciplinary nature of Materials Science and Engineering. The papers presented in this issue deal not only with basic research but also with applied problems of materials science. The presented topics include theoretical and experimental investigations on polymer composite materials (synthetic and bio-based), metallic materials and ceramics, as well as nano-materials of different kind. Special thanks should be directed to the senior staff of Division of Materials Science at LTU who agreed to review submitted papers and thus ensured high scientific level of content of this collection of papers. The following colleagues participated in the review process: Professor Lennart Walström, Professor Roberts Joffe, Professor Janis Varna, Associate Professor Marta-Lena Antti, Dr Esa Vuorinen, Professor Aji Mathew, Professor Alexander Soldatov, Dr Andrejs Purpurs, Dr Yvonne Aitomäki, Dr Robert Pederson. Roberts Joffe October 2013, Luleå Conference photograph EEIGM7 conference participants, 22 March 2013 The PDF contains the book of abstracts.

An Analysis of Individual and Institutional Levels of Productivity for Reading Journals and Conferences.

ERIC Educational Resources Information Center

Hopkins, Carol J.

A study was undertaken to portray the levels of productivity of reading professionals for the past seven years, to determine the productivity ratings of institutions based on publications in reading journals and presentations at National Reading Conferences, and to identify the most productive individuals in terms of publications in reading…

Fifth International Conference on High Energy Density Physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beg, Farhat

The Fifth International Conference on High Energy Density Physics (ICHED 2015) was held in the Catamaran Hotel in San Diego from August 23-27, 2015. This meeting was the fifth in a series which began in 2008 in conjunction with the April meeting of the American Physical Society (APS). The main goal of this conference has been to bring together researchers from all fields of High Energy Density Science (HEDS) into one, unified meeting.

2008 Joint Chemical Biological, Radiological and Nuclear (CBRN) Conference and Exhibition

DTIC Science & Technology

2008-06-26

Untitled Document 2008cbrn.html[5/16/ 2016 10:15:46 AM] 2008 Joint Chemical Biological, Radiological and Nuclear (CBRN) Conference & Exhibition... 2016 10:15:46 AM] Mr. Fred Crowson, Chief, Physical Science and Technology Division, Joint Science & Technology Office for Chemical and Biological... analysis Detect and measure alpha, beta, gamma, neutron, and x-ray emissions Levels A, B, and C capable Level A Level B 2-Jul-08 10 Extract Capabilities

Resistance management strategies in malaria vector mosquito control. Baseline data for a large-scale field trial against Anopheles albimanus in Mexico.

PubMed

Penilla, R P; Rodríguez, A D; Hemingway, J; Torres, J L; Arredondo-Jiménez, J I; Rodríguez, M H

1998-07-01

A high level of DDT resistance and low levels of resistance to organophosphorus, carbamate and pyrethroid insecticides were detected by discriminating dose assays in field populations of Anopheles albimanus in Chiapas, southern Mexico, prior to a large-scale resistance management project described by Hemingway et al. (1997). Biochemical assays showed that the DDT resistance was caused by elevated levels of glutathione S-transferase (GST) activity leading to increased rates of metabolism of DDT to DDE. The numbers of individuals with elevated GST and DDT resistance were well correlated, suggesting that this is the only major DDT resistance mechanism in this population. The carbamate resistance in this population is conferred by an altered acetylcholinesterase (AChE)-based resistance mechanism. The level of resistance observed in the bioassays correlates with the frequency of individuals homozygous for the altered AChE allele. This suggests that the level of resistance conferred by this mechanism in its heterozygous state is below the level of detection by the WHO carbamate discriminating dosage bioassay. The low levels of organophosphate (OP) and pyrethroid resistance could be conferred by either the elevated esterase or monooxygenase enzymes. The esterases were elevated only with the substrate pNPA, and are unlikely to be causing broad spectrum OP resistance. The altered AChE mechanism may also be contributing to the OP but not the pyrethroid resistance. Significant differences in resistance gene frequencies were obtained from the F1 mosquitoes resulting from adults obtained by different collection methods. This may be caused by different insecticide selection pressures on the insects immediately prior to collection, or may be an indication that the indoor- and outdoor-resting A. albimanus collections are not from a randomly mating single population. The underlying genetic variability of the populations is currently being investigated by molecular methods.

Industrial College of the Armed Forces and Mobilization Concepts Development Center Annual Mobilization Conference Proceedings (6th) Held 16-17 April 1987: Marshaling Resources for Conflict Short of Declared War; Do We have a Process.

DTIC Science & Technology

1987-04-17

stranger to this campus, to the issue of this Conference or, indeed I suspect, to most of this audience. I need, therefore, note only two things. First, Dr... most critical thing you could ever do would be to get involved in a war situation. But you can count on the fingers of one hand the number of high-level... most people think, "Well, it’ll be kind of a quick in and out, sort of like we did with Libya" -- we get all geared up, we go bomb, we get out and it’s

Career Counseling Information

DTIC Science & Technology

1989-01-01

heart disease as described by the National Institutes of Health Conference on Obesity. Fat is clearly the culprit, not total body weight. Overweight is...requiring high-level security clearance, long lead time and specialized training, or overseas screening. This expanded window will allow most personnel with ...replaced with a comprehensive Career Leader Development Program (CLDP). CLDP will include Petty officer Indoctrination Course (POIC); Chief Petty officer

Self-Assembly of Reconfigurable By-Design Optical Materials with Molecular-Level Control

DTIC Science & Technology

2014-09-21

International Conference on Metamaterials, Photonic Crystals and Plasmonics, Singapore, May 20 - 23, 2014. Zhang, W. “Design, Synthesis, and Applications of...metal  nanoparticles  positioned  in  3D   crystal   lattices...materials such as photonic crystal and metamaterial hold high promise of providing a path to by-design optical materials with engineered optical

PREFACE: 12th High-Tech Plasma Processes Conference (HTPP-12)

NASA Astrophysics Data System (ADS)

Gleizes, Alain; Ghedini, Emanuele; Gherardi, Matteo; Sanibondi, Paolo; Dilecce, Giorgio

2012-12-01

The High-Tech Plasma Processes - 12th European Plasma Conference (HTPP-12) was held in Bologna (Italy) on 24-29 June 2012. The conference series started in 1990 as a thermal plasma conference and gradually expanded to include other topic fields as well. Now the High-Tech Plasma Processes - European Plasma Conference (HTPP) is a bi-annual international conference based in Europe with topics encompassing the whole area of plasma processing science. The aim of the conference is to bring different scientific communities together, facilitate the contacts between science, technology and industry and provide a platform for the exploration of both fundamental topics and new applications of plasmas. Thanks to the efforts of the conference chairman, Professor Vittorio Colombo and of the co-chair, Professor Piero Favia, a well balanced participation from both the communities of thermal and nonthermal plasma researchers was achieved; this resulted in just about 196 attendees from 39 countries, with 8 plenary and 15 invited talks, plus 50 oral and 140 poster contributions. This volume of Journal of Physics: Conference Series gathers papers from regular contributions of HTPP-12; each contribution submitted for publication has been peer reviewed and the Editors are very grateful to the referees for their careful support in improving the original manuscripts. In the end, 39 manuscripts were accepted for publication, covering different topics of plasma processing science: from plasma fundamentals and modelling to source design and process diagnostics, from nanomaterial synthesis to surface modification, from waste treatment to plasma applications in a liquid environment. It is an honour to present this volume of Journal of Physics: Conference Series and we deeply thank the authors for their enthusiastic and high-grade contribution. Finally, we would like to thank the conference chairmen, the members of the steering committee, the international scientific committee, the local organizing committee, the organizing secretariat and the financial support from the conference sponsors that allowed the success of HTPP-12. The Editors of the HTPP 12 Proceedings Professor Alain Gleizes (head of the ISC) Dr Emanuele Ghedini Dr Matteo Gherardi Dr Paolo Sanibondi Dr Giorgio Dilecce Bologna, 30 October 2012

Next-generation sequencing reveals a Novel NSCLC ALK F1174V mutation and confirms ALK G1202R mutation confers high-level resistance to alectinib (CH5424802/RO5424802) in ALK-rearranged NSCLC patients who progressed on crizotinib.

PubMed

Ignatius Ou, Sai-Hong; Azada, Michele; Hsiang, David J; Herman, June M; Kain, Tatiana S; Siwak-Tapp, Christina; Casey, Cameron; He, Jie; Ali, Siraj M; Klempner, Samuel J; Miller, Vincent A

2014-04-01

Acquired secondary mutations in the anaplastic lymphoma kinase (ALK) gene have been identified in ALK-rearranged (ALK+) non-small-cell lung cancer (NSCLC) patients who developed disease progression while on crizotinib treatment. Here, we identified a novel secondary acquired NSCLC ALK F1174V mutation by comprehensive next-generation sequencing in one ALK+ NSCLC patient who progressed on crizotinib after a prolonged partial response to crizotinib. In a second case, we identified a secondary acquired ALK G1202R, which also confers resistance to alectinib (CH5424802/RO5424802), a second-generation ALK inhibitor that can inhibit ALK gatekeeper L1196M mutation in vitro. ALK G1202R is located at the solvent front of the ALK kinase domain and exhibits a high level of resistance to all other ALK inhibitors currently in clinical development in vitro. Comprehensive genomic profiling of resistant tumor is increasingly important in tailoring treatment decisions after disease progression on crizotinib in ALK+ NSCLC given the promise of second-generation ALK inhibitors and other therapeutic strategies.

Race, Genetics and Medicine: New Information, Enduring Questions: Final Report on Conference held on April 9, 2005 and its Sequelae

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beckwith, Jonathan R.

The Conference, “Race, Genetics and Medicine: New Information, Enduring Questions,” was held on Saturday, April 9, 2005 in the Science Center, Lecture Hall D at Harvard University, Cambridge, MA. Approximately 150 people attended. The audience was composed mainly of college and graduate school science students and postdoctoral fellows, some science and medical school faculty, science teachers at various levels, journalists and interested members of the public. The keynote speaker and the panelists reflected different academic disciplines (genetics, medicine, anthropology, sociology) and a CEO of a biotechnology company with background in medicine and law. They also presented different perspectives on themore » utility of race concepts in medicine and even on the use of the word “race.” While the talks often involved descriptions of genetic approaches that were not simple to explain, the speakers did an effective job of getting across the gist of studies that have been carried out on these issues. Although no consensus was reached, the conference gave the audience the opportunity to understand the issues and to have the tools to follow the debates in the future. Our strongest feedback was from attendees who had heard of the race and genetics issues through various media, but did not have a sense of what they were really about. They reported to us that they now felt they understood the basis of these discussions. Our post-conference activities have been successfully completed. While we had proposed to make available transcripts of the talks to the public through a Website, some of the speakers would not agree to have their presentations available in this way. Therefore, we asked permission from the DOE to use the funds to prepare classroom lesson plans for high school students to discuss the issues. These were prepared over a year-long period by the Genetic Screening Study Group Members with an educator, Ms. Ronnee Yashon, who teaches at Tufts University and who had long experience as a high school biology teacher. The lesson plans were then distributed for free to high school teachers attending the annual Conferences of the National Association of Biology Teachers and the National Science Teachers Association. One of the participants in our Conference, Professor Evelynn Hammonds of Harvard University, subsequently initiated a study group comprising faculty from a number of different New England universities and colleges, who have been analyzing the issues raised at the conference. That group, of which I am a member, has published an article examining the issues in a recent issue of PLoS Medicine. In summary, the Conference was successful in directly communicating to the public an understanding of these controversial issues, providing materials for teaching about the subject in schools, and stimulated others to involve themselves more deeply in the issues. Included with this Report are a copy of the Program for the Conference and a copy of the prepared high school Lesson Plans.« less

The Imperative Educational Network: Parents, Teachers, and Concerned Individuals. Volume 4. Proceedings of the Imperative Educational Network Conference (Athens, Georgia, 1992).

ERIC Educational Resources Information Center

Tomlinson, Louise M., Ed.

This conference sought to provide a forum for the exchange of ideas on how parents, teachers, and other concerned individuals can contribute to strengthening the educational support system, and sought to generate practical information on strategies to improve achievement levels of youth. A conference program prospectus by Louise M. Tomlinson…

Proceedings of the New England Conference on Ocean Science Education, Woods Hole, Massachusetts, May 1966.

ERIC Educational Resources Information Center

Mangelsdorf, Frederick E.; And Others

Reported are the papers presented at the New England Conference on Ocean Science Education. The purpose of the conference was to bring together prominent oceanographers and New England educators at the primary and secondary level to discuss current progress in oceanographic research and to relate this progress to the needs of schools for materials…

Change Strategies and Disabled Persons: Postsecondary Education and Beyond. National Conference (2nd, Dayton, Ohio, October 3-6, 1978).

ERIC Educational Resources Information Center

Marx, Pat, Ed.; Hall, Perry, Ed.

The document presents proceedings on the second national conference on the physically disabled student at the postsecondary level. Specific conference objectives were: (1) to develop an understanding of the impact of attitudes on service to design and delivery and to identify effective techniques for attitude development; (2) to identify methods…

Architects of the Future. Selected Conference Papers, Volume 1. National Association for Developmental Education Annual Conference Proceedings (19th, Chicago, Illinois, February 22-26, 1995).

ERIC Educational Resources Information Center

Higbee, Jeanne L., Ed.; Dwinell, Patricia L., Ed.

This conference proceedings publication addresses issues in developmental education at the postsecondary level. Papers included are: "Developmental Studies Teachers to Retention Specialists: Assets, Not Liabilities" (Carol H. Bader); "Primary and Secondary Orientation Support for One Underrepresented Group" (Allen R. Barlow and Kerri Heavens);…

Financial Measures Conference: Progress in Measuring Financial Conditions of Colleges and Universities. Proceedings of the 1979 Working Conference (Annapolis, Maryland, September 27-28, 1979).

ERIC Educational Resources Information Center

Stich, Judith, Ed.

Proceedings of the 1979 Financial Measures Conference which assess "Progress in Measuring Financial Conditions of Colleges and Universities" are presented. Focus is the prospective uses of financial indicators and the results of attempts to employ indicators at the institutional, state, regional, and federal levels for management, and…

The Imperative Educational Network: Parents, Teachers, and Concerned Individuals. Volume 2. Proceedings of the Imperative Educational Network Conference (Athens, Georgia, 1990).

ERIC Educational Resources Information Center

Tomlinson, Louise M., Ed.

This conference was designed to provide a forum for the exchange of ideas on how parents, teachers, and other concerned individuals can contribute to strengthening the educational support system, and to generate practical information on strategies to improve achievement levels of youth. The first article, titled "Conference Program…

European Physical Society Conference on High Energy Physics

NASA Astrophysics Data System (ADS)

The European Physical Society Conference on High Energy Physics, organized by the High Energy and Particle Physics Division of the European Physical Society, is a major international conference that reviews biennially since 1971 the state of our knowledge of the fundamental constituents of matter and their interactions. The latest conferences in this series were held in Stockholm, Grenoble, Krakow, Manchester, Lisbon, and Aachen. Jointly organized by the Institute of High Energy Physics of the Austrian Academy of Sciences, the University of Vienna, the Vienna University of Technology, and the Stefan Meyer Institute for Subatomic Physics of the Austrian Academy of Sciences, the 23rd edition of this conference took place in Vienna, Austria. Among the topics covered were Accelerators, Astroparticle Physics, Cosmology and Gravitation, Detector R&D and Data Handling, Education and Outreach, Flavour Physics and Fundamental Symmetries, Heavy Ion Physics, Higgs and New Physics, Neutrino Physics, Non-Perturbative Field Theory and String Theory, QCD and Hadronic Physics, as well as Top and Electroweak Physics.

National Longitudinal Study Planning Conference, October 1-3, 1975. Final Paper from the Panel.

ERIC Educational Resources Information Center

Howard, Walter R.

This planning conference was one in a series of such conferences aimed at providing continuous guidance for the development of the National Longitudinal Study of the High School Class of 1972 (NLS) a study designed to discover what happens to young adults after they leave high school, and to relate this information to earlier educational…

Post-exposure treatment of Ebola virus disease in guinea pigs using EBOTAb, an ovine antibody-based therapeutic.

PubMed

Dowall, Stuart D; Bosworth, Andrew; Rayner, Emma; Taylor, Irene; Landon, John; Cameron, Ian; Coxon, Ruth; Al Abdulla, Ibrahim; Graham, Victoria A; Hall, Graham; Kobinger, Gary; Hewson, Roger; Carroll, Miles W

2016-07-28

Ebola virus (EBOV) is highly pathogenic, with a predisposition to cause outbreaks in human populations accompanied by significant mortality. An ovine polyclonal antibody therapy has been developed against EBOV, named EBOTAb. When tested in the stringent guinea pig model of EBOV disease, EBOTAb has been shown to confer protection at levels of 83.3%, 50% and 33.3% when treatment was first started on days 3, 4 and 5 post-challenge, respectively. These timepoints of when EBOTAb treatment was initiated correspond to when levels of EBOV are detectable in the circulation and thus mimic when treatment would likely be initiated in human infection. The effects of EBOTAb were compared with those of a monoclonal antibody cocktail, ZMapp, when delivered on day 3 post-challenge. Results showed ZMapp to confer complete protection against lethal EBOV challenge in the guinea pig model at this timepoint. The data reported demonstrate that EBOTAb is an effective treatment against EBOV disease, even when delivered late after infection.

Intragroup Contact and Anxiety Among Ethnic Minority Adolescents: Considering Ethnic Identity and School Diversity Transitions

PubMed Central

Yip, Tiffany; Shelton, J. Nicole

2015-01-01

Everyday interactions with same-racial/ethnic others may confer positive benefits for adolescents, but the meaning of these interactions are likely influenced by individual differences and larger structural contexts. This study examined the situation-level association between contact with same-ethnic others and anxiety symptoms among a diverse sample of 306 racial/ethnic minority adolescents (Mage = 14 years; 66 % female), based on (1) individual differences in ethnic identity centrality and (2) developmental histories of transitions in diversity between elementary, middle, and high school. The results indicated that at the level of the situation, when adolescents interacted with more same-ethnic others, they reported fewer anxiety symptoms. Further, for adolescents who had experienced a transition in school diversity, the positive benefits of contact with same-ethnic others was only conferred for those who felt that their ethnicity was very important to them. The importance of examining individual differences within larger developmental histories to understand the everyday experiences of ethnic minority adolescents are discussed. PMID:24951944

Climate for Articulation. Report of a Conference of Vocational Directors and Technical College Presidents and Directors in South Carolina, October 12-14, 1978.

ERIC Educational Resources Information Center

White, Robert H., Ed.

A summary is presented of the proceedings of a South Carolina conference of vocational and technical college presidents and directors which focused on (1) the articulation of selected secondary level vocational education and similar postsecondary level technical institution programs and (2) mutual concerns of vocational directors and technical…

"Loops and Legs in Quantum Field Theory", 12th DESY Workshop on Elementary Particle Physics

NASA Astrophysics Data System (ADS)

The bi-annual international conference "Loops and Legs in Quantum Field Theory" has been held at Weimar, Germany, from April 27 to May 02, 2014. It has been the 12th conference of this series, started in 1992. The main focus of the conference are precision calculations of multi- loop and multi-leg processes in elementary particle physics for processes at present and future high-energy facilities within and beyond the Standard Model. At present many physics questions studied deal with processes at the LHC and future facilities like the ILC. A growing number of contributions deals with important developments in the field of computational technologies and algorithmic methods, including large-scale computer algebra, efficient methods to compute large numbers of Feynman diagrams, analytic summation and integration methods of various kinds, new related function spaces, precise numerical methods and Monte Carlo simulations. The present conference has been attended by more than 110 participants from all over the world, presenting more than 75 contributions, most of which have been written up for these pro- ceedings. The present volume demonstrates in an impressive way the enormous development of the field during the last few years, reaching the level of 5-loop calculations in QCD and a like- wise impressive development in massive next-to-leading order and next-to-next-to-leading order processes. Computer algebraic and numerical calculations require terabyte storage and many CPU years, even after intense parallelization, to obtain state-of-the-art theoretical predictions. The city of Weimar gave a suitable frame to the conference, with its rich history, especially in literature, music, arts, and architecture. Goethe, Schiller, Wieland, Herder, Bach and Liszt lived there and created many of their masterpieces. The many young participants signal that our field is prosperous and faces an exciting future. The conference hotel "Kaiserin Augusta" offered a warm hospitality and excellent working conditions. We would like to thank Martina Mende for all her work in helping to organize this conference. Details of the conference can be found under: https://indico.desy.de/conferenceDisplay.py?confId=8107

PREFACE: EUCAS '09: The 9th European Conference on Applied Superconductivity (Dresden, Germany, 13-17 September 2009) EUCAS '09: The 9th European Conference on Applied Superconductivity (Dresden, Germany, 13-17 September 2009)

NASA Astrophysics Data System (ADS)

Holzapfel, Bernhard; Schultz, Ludwig; Schlörb, Heike

2010-03-01

During the 9th European Conference on Applied Superconductivity, 6 plenary, 22 invited, 206 oral and 429 poster contributions were presented on recent developments in the field of applied superconductivity. This issue of Superconductor Science and Technology contains plenary, invited and a selection of contributed oral papers of the four main EUCAS areas: materials, wires and tapes, large scale applications and electronics. The remaining contributed papers that were selected for the conference proceedings will be published in the Journal of Physics: Conference Series. The Dresden EUCAS conference, with 712 participants from 43 countries, continued the tradition of preceding EUCAS conferences of combining basic superconductivity research contributions with the discussion of recent material advances and new developments in large scale and electronic applications. In Dresden, contributions on the recently discovered Fe-based superconductors were presented for the first time during a EUCAS conference and their potential for applications was intensively discussed. Among all the high level papers of this issue we particularly want to highlight the plenary contribution of Praveen Chaudhari on grain boundaries in cuprate superconductors. In his paper Praveen discusses the Jc limitation in HTSC tapes and tunnelling spectroscopy in LSCO thin film bicrystals. Just a few weeks ago we received the sad news that Praveen had passed away on 13 January 2010. Already fighting with his serious illness, Praveen spent all his efforts last fall finishing his plenary talk and paper. This paper will remind us always of his contributions to basic and applied aspects of superconductivity in general and especially his important work on HTSC grain boundaries. Finally we want to acknowledge the help of the International Advisory and National Committees in setting up the scientific program and we would especially like to express our gratitude to all the members of the Local Organization Committee. Their enthusiastic and well organized work made this Dresden EUCAS conference a memorable event for all participants.

An Arabidopsis Soil-Salinity–Tolerance Mutation Confers Ethylene-Mediated Enhancement of Sodium/Potassium Homeostasis[W

PubMed Central

Jiang, Caifu; Belfield, Eric J.; Cao, Yi; Smith, J. Andrew C.; Harberd, Nicholas P.

2013-01-01

High soil Na concentrations damage plants by increasing cellular Na accumulation and K loss. Excess soil Na stimulates ethylene-induced soil-salinity tolerance, the mechanism of which we here define via characterization of an Arabidopsis thaliana mutant displaying transpiration-dependent soil-salinity tolerance. This phenotype is conferred by a loss-of-function allele of ETHYLENE OVERPRODUCER1 (ETO1; mutant alleles of which cause increased production of ethylene). We show that lack of ETO1 function confers soil-salinity tolerance through improved shoot Na/K homeostasis, effected via the ETHYLENE RESISTANT1–CONSTITUTIVE TRIPLE RESPONSE1 ethylene signaling pathway. Under transpiring conditions, lack of ETO1 function reduces root Na influx and both stelar and xylem sap Na concentrations, thereby restricting root-to-shoot delivery of Na. These effects are associated with increased accumulation of RESPIRATORY BURST OXIDASE HOMOLOG F (RBOHF)–dependent reactive oxygen species in the root stele. Additionally, lack of ETO1 function leads to significant enhancement of tissue K status by an RBOHF-independent mechanism associated with elevated HIGH-AFFINITY K+ TRANSPORTER5 transcript levels. We conclude that ethylene promotes soil-salinity tolerance via improved Na/K homeostasis mediated by RBOHF-dependent regulation of Na accumulation and RBOHF-independent regulation of K accumulation. PMID:24064768

Proceedings of the Air Force Conference on Fatigue and Fracture of Aircraft Structures and Materials Held at Miami Beach, Florida on 15-18 December 1969

DTIC Science & Technology

1970-12-01

a Circular Hole A.S. Kobayashi and D.E. Maiden 217 Fatigue Performance of High Strength An Effective Strain Concept for Steels as Related to Their a ...in AFLC Col. H.B. Morrison, Jr. 899 Results of Analysis, Fatigue Testing and Usage of a High Speed Aircraft Subjected to Combined Peacetime and High ...on the level of the in a recent study of the fatigue performance of some stable elastic limit that can be produced by dislocation pin- high yield

Breakthrough in chloroplast genetic engineering of agronomically important crops

PubMed Central

Daniell, Henry; Kumar, Shashi; Dufourmantel, Nathalie

2012-01-01

Chloroplast genetic engineering offers several unique advantages, including high-level transgene expression, multi-gene engineering in a single transformation event and transgene containment by maternal inheritance, as well as a lack of gene silencing, position and pleiotropic effects and undesirable foreign DNA. More than 40 transgenes have been stably integrated and expressed using the tobacco chloroplast genome to confer desired agronomic traits or express high levels of vaccine antigens and biopharmaceuticals. Despite such significant progress, this technology has not been extended to major crops. However, highly efficient soybean, carrot and cotton plastid transformation has recently been accomplished through somatic embryogenesis using species-specific chloroplast vectors. This review focuses on recent exciting developments in this field and offers directions for further research and development. PMID:15866001

PREFACE: 2nd International Workshop on Theoretical and Computational Physics (IWTCP-2): Modern Methods and Latest Results in Particle Physics, Nuclear Physics and Astrophysics and the 39th National Conference on Theoretical Physics (NCTP-39)

NASA Astrophysics Data System (ADS)

Hoang, Trinh Xuan; Ky, Nguyen Anh; Lan, Nguyen Tri; Viet, Nguyen Ai

2015-06-01

This volume contains selected papers presented at the 2nd International Workshop on Theoretical and Computational Physics (IWTCP-2): Modern Methods and Latest Results in Particle Physics, Nuclear Physics and Astrophysics and the 39th National Conference on Theoretical Physics (NCTP-39). Both the workshop and the conference were held from 28th - 31st July 2014 in Dakruco Hotel, Buon Ma Thuot, Dak Lak, Vietnam. The NCTP-39 and the IWTCP-2 were organized under the support of the Vietnamese Theoretical Physics Society, with a motivation to foster scientific exchanges between the theoretical and computational physicists in Vietnam and worldwide, as well as to promote high-standard level of research and education activities for young physicists in the country. The IWTCP-2 was also an External Activity of the Asia Pacific Center for Theoretical Physics (APCTP). About 100 participants coming from nine countries participated in the workshop and the conference. At the IWTCP-2 workshop, we had 16 invited talks presented by international experts, together with eight oral and ten poster contributions. At the NCTP-39, three invited talks, 15 oral contributions and 39 posters were presented. We would like to thank all invited speakers, participants and sponsors for making the workshop and the conference successful. Trinh Xuan Hoang, Nguyen Anh Ky, Nguyen Tri Lan and Nguyen Ai Viet

A novel resistance gene, lnu(H), conferring resistance to lincosamides in Riemerella anatipestifer CH-2.

PubMed

Luo, Hong-Yan; Liu, Ma-Feng; Wang, Ming-Shu; Zhao, Xin-Xin; Jia, Ren-Yong; Chen, Shun; Sun, Kun-Feng; Yang, Qiao; Wu, Ying; Chen, Xiao-Yue; Biville, Francis; Zou, Yuan-Feng; Jing, Bo; Cheng, An-Chun; Zhu, De-Kang

2018-01-01

The Gram-negative bacterium Riemerella anatipestifer CH-2 is resistant to lincosamides, having a lincomycin (LCM) minimum inhibitory concentration (MIC) of 128 µg/mL. The G148_1775 gene of R. anatipestifer CH-2, designated lnu(H), encodes a 260-amino acid protein with ≤41% identity to other reported lincosamide nucleotidylyltransferases. Escherichia coli Rosetta TM (DE3) containing the pBAD24-lnu(H) plasmid showed four- and two-fold increases in the MICs of LCM and clindamycin (CLI), respectively. A kinetic assay of the purified Lnu(H) enzyme for LCM and CLI showed that the protein could inactive lincosamides. Mass spectrometry analysis demonstrated that the Lnu(H) enzyme catalysed adenylylation of lincosamides. In addition, an lnu(H) gene deletion strain exhibited 512- and 32-fold decreases in LCM and CLI MICs, respectively. The wild-type level of lincosamide resistance could be restored by complementation with a shuttle plasmid carrying the lnu(H) gene. The transformant R. anatipestifer ATCC 11845 [lnu(H)] acquired by natural transformation also exhibited high-level lincosamide resistance. Moreover, among 175 R. anatipestifer field isolates, 56 (32.0%) were positive for the lnu(H) gene by PCR. In conclusion, Lnu(H) is a novel lincosamide nucleotidylyltransferase that inactivates LCM and CLI by nucleotidylylation, thus conferring high-level lincosamide resistance to R. anatipestifer CH-2. Copyright © 2017. Published by Elsevier B.V.

Progress in Applied Surface, Interface and Thin Film Science 2015. Solar Renewable Energy News IV, November 23-26, 2015, Florence, Italy (SURFINT-SREN IV)

NASA Astrophysics Data System (ADS)

2017-02-01

The main goal of the conference is to contribute to new knowledge in surface, interface, ultra-thin films and very-thin films science of inorganic and organic materials by the most rapid interactive manner - by direct communication among scientists of corresponding research fields. The list of topics indicates that conference interests cover the development of basic theoretical physical and chemical principles and performance of surfaces-, thin films-, and interface-related procedures, and corresponding experimental research on atomic scale. Topical results are applied at development of new inventive industrial equipments needed for investigation of electrical, optical, and structural properties, and other parameters of atomic-size research objects. The conference range spreads, from physical point of view, from fundamental research done on sub-atomic and quantum level to production of devices built on new physical principles. The conference topics include also presentation of principally new devices in following fields: solar cells, liquid crystal displays, high-temperature superconductivity, and sensors. During the event, special attention will be given to evaluation of scientific and technical quality of works prepared by PhD students, to deep ecological meaning of solar cell energy production, and to exhibitions of companies.

Opening All Options. Proceedings of the Ohio Middle School and Junior High School Career Guidance Conference (Columbus, Ohio, June 24-26, 1987).

ERIC Educational Resources Information Center

Ohio State Dept. of Education, Columbus.

This document presents the conference proceedings of a career guidance conference which focused attention on the need to develop a comprehensive career guidance program in Ohio middle and junior high schools. Papers include: (1) "Competency-Based Guidance Programs: A Model of the Future" (C. D. Johnson and Sharon Johnson); (2) "How…

The 1992 NASA Langley Measurement Technology Conference: Measurement Technology for Aerospace Applications in High-Temperature Environments

NASA Technical Reports Server (NTRS)

Singh, Jag J. (Editor); Antcliff, Richard R. (Editor)

1992-01-01

An intensive 2-day conference to discuss the current status of measurement technology in the areas of temperature/heat flux, stress/strain, pressure, and flowfield diagnostics for high temperature aerospace applications was held at Langley Research Center, Hampton, Virginia, on April 22 and 23, 1993. Complete texts of the papers presented at the Conference are included in these proceedings.

The Imperative Educational Network: Parents, Teachers, and Concerned Individuals. Volume 3. Proceedings of the Imperative Educational Network Conference (Athens, Georgia, 1991).

ERIC Educational Resources Information Center

Tomlinson, Louise M., Ed.

This conference sought to provide a forum for the exchange of ideas on how parents, teachers, and other concerned individuals can contribute to strengthening the educational support system, and to generate practical information on strategies to improve achievement levels of youth. A conference program prospectus by Louise M. Tomlinson offers a…

Museums and the Web 2001: Selected Papers from an International Conference (5th, Seattle, Washington, March 15-17, 2001).

ERIC Educational Resources Information Center

Bearman, David, Ed.; Trant, Jennifer, Ed.

In this selection of papers from the conference, authors from 10 of the more than 35 countries and every continent (except Antarctica) provide discussions covering all levels of museum Web design. They brought a wide variety of experiences and backgrounds to the conference, all of which ensured new perspectives and new ideas. The meetings opened…

ED-MEDIA/ED-TELECOM 98 World Conference on Educational Multimedia and Hypermedia & World Conference on Educational Telecommunications. Proceedings (10th, Freiburg, Germany, June 20-25, 1998).

ERIC Educational Resources Information Center

Ottmann, Thomas, Ed.; Tomek, Ivan, Ed.

This collection presents papers pertaining to the wide area of educational multimedia/hypermedia and telecommunications. The conference serves as a forum for the dissemination of information on the research, development, and applications in all areas of multimedia/hypermedia and telecommunications in education across all disciplines and levels.…

Conference on Bio-Social Factors in the Development and Learning of Disadvantaged Children. Conference Proceedings (Syracuse, New York, April 19-21, 1967).

ERIC Educational Resources Information Center

Yeshiva Univ., New York, NY. Ferkauf Graduate School of Humanities and Social Sciences.

These conference proceedings contain two major papers. The paper by Susan S. Stodolsky and Gerald S. Lesser, "Learning Patterns in the Disadvantaged," reports a study of effects of social class and ethnic group influences on levels and patterns of mental ability. Scores for verbal ability, reasoning, number facility, and space conceptualization of…

Transgenic cotton expressing Cry10Aa toxin confers high resistance to the cotton boll weevil.

PubMed

Ribeiro, Thuanne Pires; Arraes, Fabricio Barbosa Monteiro; Lourenço-Tessutti, Isabela Tristan; Silva, Marilia Santos; Lisei-de-Sá, Maria Eugênia; Lucena, Wagner Alexandre; Macedo, Leonardo Lima Pepino; Lima, Janaina Nascimento; Santos Amorim, Regina Maria; Artico, Sinara; Alves-Ferreira, Márcio; Mattar Silva, Maria Cristina; Grossi-de-Sa, Maria Fatima

2017-08-01

Genetically modified (GM) cotton plants that effectively control cotton boll weevil (CBW), which is the most destructive cotton insect pest in South America, are reported here for the first time. This work presents the successful development of a new GM cotton with high resistance to CBW conferred by Cry10Aa toxin, a protein encoded by entomopathogenic Bacillus thuringiensis (Bt) gene. The plant transformation vector harbouring cry10Aa gene driven by the cotton ubiquitination-related promoter uceA1.7 was introduced into a Brazilian cotton cultivar by biolistic transformation. Quantitative PCR (qPCR) assays revealed high transcription levels of cry10Aa in both T 0 GM cotton leaf and flower bud tissues. Southern blot and qPCR-based 2 -ΔΔCt analyses revealed that T 0 GM plants had either one or two transgene copies. Quantitative and qualitative analyses of Cry10Aa protein expression showed variable protein expression levels in both flower buds and leaves tissues of T 0 GM cotton plants, ranging from approximately 3.0 to 14.0 μg g -1 fresh tissue. CBW susceptibility bioassays, performed by feeding adults and larvae with T 0 GM cotton leaves and flower buds, respectively, demonstrated a significant entomotoxic effect and a high level of CBW mortality (up to 100%). Molecular analysis revealed that transgene stability and entomotoxic effect to CBW were maintained in T 1 generation as the Cry10Aa toxin expression levels remained high in both tissues, ranging from 4.05 to 19.57 μg g -1 fresh tissue, and the CBW mortality rate remained around 100%. In conclusion, these Cry10Aa GM cotton plants represent a great advance in the control of the devastating CBW insect pest and can substantially impact cotton agribusiness. © 2017 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

Second topical conference on high-temperature plasma diagnostics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jahoda, F.C.; Freese, K.B.

1978-02-01

This report contains the program and abstracts of papers presented at the Second American Physical Society Topical Conference on High Temperature Plasma Diagnostics, March 1-3, 1978, Santa Fe, New Mexico.

Elevated Cell Wall Chitin in Candida albicans Confers Echinocandin Resistance In Vivo

PubMed Central

Lee, Keunsook K.; MacCallum, Donna M.; Jacobsen, Mette D.; Walker, Louise A.; Odds, Frank C.

2012-01-01

Candida albicans cells with increased cell wall chitin have reduced echinocandin susceptibility in vitro. The aim of this study was to investigate whether C. albicans cells with elevated chitin levels have reduced echinocandin susceptibility in vivo. BALB/c mice were infected with C. albicans cells with normal chitin levels and compared to mice infected with high-chitin cells. Caspofungin therapy was initiated at 24 h postinfection. Mice infected with chitin-normal cells were successfully treated with caspofungin, as indicated by reduced kidney fungal burdens, reduced weight loss, and decreased C. albicans density in kidney lesions. In contrast, mice infected with high-chitin C. albicans cells were less susceptible to caspofungin, as they had higher kidney fungal burdens and greater weight loss during early infection. Cells recovered from mouse kidneys at 24 h postinfection with high-chitin cells had 1.6-fold higher chitin levels than cells from mice infected with chitin-normal cells and maintained a significantly reduced susceptibility to caspofungin when tested in vitro. At 48 h postinfection, caspofungin treatment induced a further increase in chitin content of C. albicans cells harvested from kidneys compared to saline treatment. Some of the recovered clones had acquired, at a low frequency, a point mutation in FKS1 resulting in a S645Y amino acid substitution, a mutation known to confer echinocandin resistance. This occurred even in cells that had not been exposed to caspofungin. Our results suggest that the efficacy of caspofungin against C. albicans was reduced in vivo due to either elevation of chitin levels in the cell wall or acquisition of FKS1 point mutations. PMID:21986821

High Stakes Testing and Reading Assessment. National Reading Conference Policy Brief

ERIC Educational Resources Information Center

Afflerbach, Peter

2005-01-01

This National Reading Conference Policy Brief provides information related to high stakes reading tests and reading assessment. High stakes reading tests are those with highly consequential outcomes for students, teachers, and schools. These outcomes may include student promotion or retention, student placement in reading groups, school funding…

An evaluation of two H1-linked markers and their suitability for selecting Globodera rostochiensis resistant potatoes in the New York breeding program

USDA-ARS?s Scientific Manuscript database

The golden cyst nematode (Globodera rostochiensis) is a serious pest that can dramatically reduce potato crop yield. Pathotype Ro1 of G. rostochiensis was first detected in the United States in 1941 and is still present on several farms in New York State. The H1 gene confers high levels of resistan...

China’s International Behavior. Activism, Opportunism, and Diversification

DTIC Science & Technology

2009-01-01

military, science and technology, culture, education, and tourism . In the words of reports from the high- level 2006 Central Conference on Foreign...services took effect in July 2007 and covers construction, environmental protection, tourism , transportation, and education. Talks on investment and...legitimacy and gover - nance practices are not a priority for China in its bilateral relations.163 Such issues become relevant to Chinese leaders and

Retiree Health Plans for Public School Teachers after GASB 43 and 45. Conference Paper 2009-03

ERIC Educational Resources Information Center

Clark, Robert L.

2009-01-01

Most public elementary and high school teachers are covered by health insurance provided by their employer while they are employed. In most cases, these health plans are managed at the state level. At retirement, teachers with sufficient years of service are allowed to remain in the health plan. Retiree health plans for teachers vary widely across…

GE STEM Teacher's Conference

NASA Image and Video Library

2017-07-13

Education Specialists Lynn Dotson, left, of the NASA Public Engagement Center, and Lester Morales, right, of Texas State University's NASA STEM Educator Professional Development Collaborative, explain the Rocketry Engineering Design Challenge to teachers participating in the 2017 GE Foundation High School STEM Integration Conference at the Center for Space Education at NASA's Kennedy Space Center. High school teachers from across the country took part in the week-long conference, which is designed to explore effective ways for teachers, schools and districts from across the country to integrate STEM throughout the curriculum. The conference is a partnership between GE Foundation and the National Science Teachers Association.

N-Acetylcysteine and Allopurinol Confer Synergy in Attenuating Myocardial Ischemia Injury via Restoring HIF-1α/HO-1 Signaling in Diabetic Rats

PubMed Central

Mao, Xiaowen; Wang, Tingting; Liu, Yanan; Irwin, Michael G.; Ou, Jing-song; Liao, Xiao-long; Gao, Xia; Xu, Yuan; Ng, Kwok F. J.; Vanhoutte, Paul M.; Xia, Zhengyuan

2013-01-01

Objectives To determine whether or not the antioxidants N-acetylcysteine (NAC) and allopurinol (ALP) confer synergistic cardioprotection against myocardial ischemia/reperfusion (MI/R) injury by stabilizing hypoxia inducible factor 1α (HIF-1α)/heme oxygenase 1 (HO-1) signaling in diabetic myocardium. Methods Control or diabetic [streptozotocin (STZ)-induced] Sprague Dawley rats received vehicle or NAC, ALP or their combination for four weeks starting one week after STZ injection. The animals were then subjected to thirty minutes of coronary artery occlusion followed by two hours reperfusion in the absence or presence of the selective HO-1 inhibitor, tin protoporphyrin-IX (SnPP-IX) or the HIF-1α inhibitor 2-Methoxyestradiol (2ME2). Cardiomyocytes exposed to high glucose were subjected to hypoxia/re-oxygenation in the presence or absence of HIF-1α and HO-1 achieved by gene knock-down with related siRNAs. Results Myocardial and plasma levels of 15-F2t-isoprostane, an index of oxidative stress, were significantly increased in diabetic rats while cardiac HO-1 protein and activity were reduced; this was accompanied with reduced cardiac protein levels of HIF-1α, and increased post-ischemic myocardial infarct size and cellular injury. NAC and ALP given alone and in particular their combination normalized cardiac levels of HO-1 and HIF-1α protein expression and prevented the increase in 15-F2t-isoprostane, resulting in significantly attenuated post-ischemic myocardial infarction. NAC and ALP also attenuated high glucose-induced post-hypoxic cardiomyocyte death in vitro. However, all the above protective effects of NAC and ALP were cancelled either by inhibition of HO-1 or HIF-1α with SnPP-IX and 2ME2 in vivo or by HO-1 or HIF-1α gene knock-down in vitro. Conclusion NAC and ALP confer synergistic cardioprotection in diabetes via restoration of cardiac HIF-1α and HO-1 signaling. PMID:23874823

Indicators of Performance. Papers Presented at the Annual Conference of the Society for Research into Higher Education (15th, Brighton, England, December 19-20, 1979).

ERIC Educational Resources Information Center

Billing, David, Ed.

Thirty-two papers on performance indicators are presented based on the conference themes of performance of the higher education system at the national level, institutional evaluation, and assessment of staff and students. Papers and authors include the following: "Higher Education Systems at National Level" (A. Thompson); "The CNAA…

Online consensus conferences for clinical guidelines development - a survey among participants from the International Guidelines for the Treatment of Actinic Keratosis.

PubMed

Werner, Ricardo N; Jacobs, Anja; Rosumeck, Stefanie; Nast, Alexander

2014-12-01

Guideline development requires considerable time and financial resources. New technical devices such as software for online conferences may help to reduce time and financial efforts of guidelines development. The present survey may serve as an explorative pilot for a future study to determine the technical feasibility, acceptability and possible weaknesses of online consensus conferences for clinical guidelines development. An anonymous online survey was conducted among participants in the online consensus conference of the International League of Dermatological Societies (ILDS) Guidelines for the Treatment of Actinic Keratosis. The majority of participants reported no technical problems with the participation in the online consensus conference; one participant had substantial technical problems accountable to a regional telephone breakdown. The majority of participants would not have preferred a traditional face-to-face conference, and all participants rated online consensus conferences for international guidelines as absolutely acceptable. Rates of acceptance were particularly high among those participants with prior experience with consensus conferences. Certain aspects, particularly the possibilities of debating, were rated as possibly superior in face-to-face conferences by some participants. The data from the online survey indicate that online consensus conferences may be an appropriate alternative to traditional face-to-face consensus conferences, especially within the frame of international guidelines that would require high travel costs and time. Further research is necessary to confirm the data from this explorative pilot study. © 2014 John Wiley & Sons, Ltd.

PREFACE: IC-MSQUARE 2012: International Conference on Mathematical Modelling in Physical Sciences

NASA Astrophysics Data System (ADS)

Kosmas, Theocharis; Vagenas, Elias; Vlachos, Dimitrios

2013-02-01

The first International Conference on Mathematical Modelling in Physical Sciences (IC-MSQUARE) took place in Budapest, Hungary, from Monday 3 to Friday 7 September 2012. The conference was attended by more than 130 participants, and hosted about 290 oral, poster and virtual papers by more than 460 pre-registered authors. The first IC-MSQUARE consisted of different and diverging workshops and thus covered various research fields in which mathematical modelling is used, such as theoretical/mathematical physics, neutrino physics, non-integrable systems, dynamical systems, computational nanoscience, biological physics, computational biomechanics, complex networks, stochastic modelling, fractional statistics, DNA dynamics, and macroeconomics. The scientific program was rather heavy since after the Keynote and Invited Talks in the morning, two parallel sessions ran every day. However, according to all attendees, the program was excellent with a high level of talks and the scientific environment was fruitful; thus all attendees had a creative time. The mounting question is whether this occurred accidentally, or whether IC-MSQUARE is a necessity in the field of physical and mathematical modelling. For all of us working in the field, the existing and established conferences in this particular field suffer from two distinguished and recognized drawbacks: the first is the increasing orientation, while the second refers to the extreme specialization of the meetings. Therefore, a conference which aims to promote the knowledge and development of high-quality research in mathematical fields concerned with applications of other scientific fields as well as modern technological trends in physics, chemistry, biology, medicine, economics, sociology, environmental sciences etc., appears to be a necessity. This is the key role that IC-MSQUARE will play. We would like to thank the Keynote Speaker and the Invited Speakers for their significant contributions to IC-MSQUARE. We would also like to thank the members of the International Scientific Committee and the members of the Organizing Committee. Conference Chairmen Theocharis Kosmas Department of Physics, University of Ioannina Elias Vagenas RCAAM, Academy of Athens Dimitrios Vlachos Department of Computer Science and Technology, University of Peloponnese The PDF also contains a list of members of the International Scientific Committes and details of the Keynote and Invited Speakers.

PREFACE: 13th High-Tech Plasma Processes Conference (HTPP-2014)

NASA Astrophysics Data System (ADS)

2014-11-01

The High-Tech Plasma Processes - 13th European Plasma Conference (HTPP-2014) was held in Toulouse (France) on 22-27 June 2014. The conference series started in 1990 as a thermal plasma conference and has gradually expanded to include other related topics. Now the High-Tech Plasma Processes - European Plasma Conference (HTPP) is an international conference organised in Europe every two years with topics encompassing the whole field of plasma processing science. The aim of the conference is to bring different scientific communities together, to facilitate contacts between science, technology and industry and to provide a platform for the exploration of both the fundamental topics and new applications of plasmas. For this edition of HTPP, as was the case for the last, we have acheived a well balanced participation from the communities of both thermal and non-thermal plasma researchers. 142 people from 17 countries attended the conference with the total number of contributions being 155, consisting of 8 plenary and 8 invited talks plus 51 oral and 88 poster contributions. We have received numerous papers corresponding to the contributions of HTPP-2014 that have been submitted for publication in this volume of Journal of Physics: Conference Series. Each submitted contribution has been peer reviewed (60 referees with at least two reviewing each paper) and the Editors are very grateful to the referees for their careful support in improving the original manuscripts. In total, 52 manuscripts have been accepted for publication covering a range of topics of plasma processing science from plasma fundamentals to process applications through to experiments, diagnostics and modelling. We have grouped the papers into the following 5 topics: - Arc-Materials Interaction and Metallurgy - Plasma Torches and Spraying - Synthesis of Powders and Nanomaterials - Deposition and Surface Treatment - Non-Equilibrium Plasmas We deeply thank the authors for their enthusiastic and high-grade contributions and we are convinced that this volume of Journal of Physics: Conference Series will be interesting for our community. Finally, we would like to thank the conference chairmen, the members of the steering committee, the international scientific committee, the local organizing committee, the organizing secretariat and the financial support from the conference sponsors that allowed the success of HTPP-2014. The Editors of the HTPP-2014 Proceedings Dr Alain Gleizes, chairman of HTPP-2014 Prof. Jochen Schein, head of the ISC Prof. Philippe Teulet Toulouse, 14th October 2014

New Challenges in Developing High School and Post High School Programs in Agricultural Occupations. Conference Report. Resident Instruction Series No. 5.

ERIC Educational Resources Information Center

New Mexico State Univ., University Park. Coll. of Agriculture and Home Economics.

A special 2-week conference designed to assist nine participating states in developing plans for new educational programs in agricultural occupations was hosted by the New Mexico State University, July 20-31, 1964. Major papers presented to the 35 participants were: (1) Purpose of the Conference, (2) Where We Have Been--and Where We Are Now, (3)…

SCinet Architecture: Featured at the International Conference for High Performance Computing,Networking, Storage and Analysis 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lyonnais, Marc; Smith, Matt; Mace, Kate P.

SCinet is the purpose-built network that operates during the International Conference for High Performance Computing,Networking, Storage and Analysis (Super Computing or SC). Created each year for the conference, SCinet brings to life a high-capacity network that supports applications and experiments that are a hallmark of the SC conference. The network links the convention center to research and commercial networks around the world. This resource serves as a platform for exhibitors to demonstrate the advanced computing resources of their home institutions and elsewhere by supporting a wide variety of applications. Volunteers from academia, government and industry work together to design andmore » deliver the SCinet infrastructure. Industry vendors and carriers donate millions of dollars in equipment and services needed to build and support the local and wide area networks. Planning begins more than a year in advance of each SC conference and culminates in a high intensity installation in the days leading up to the conference. The SCinet architecture for SC16 illustrates a dramatic increase in participation from the vendor community, particularly those that focus on network equipment. Software-Defined Networking (SDN) and Data Center Networking (DCN) are present in nearly all aspects of the design.« less

PREFACE: Yamada Conference LX on Research in High Magnetic Fields (RHMF2006)

NASA Astrophysics Data System (ADS)

Motokawa, Mitsuhiro

2006-12-01

The 60th Yamada Conference on Research in High Magnetic Fields (RHMF2006) was held at Sendai Civic Auditorium, Miyagi Prefecture, Japan, from 16 - 19 August 2006, as the 8th RHMF. The first was held in Osaka (1982) followed by Leuven (1988), Amsterdam (1991), Nijmegen (1994), Sydney (1997), Porto (2000), and Toulouse (2003). RHMF2006, which was also a satellite conference of the 17th International Conference on Magnetism (Kyoto, 20 - 25 August 2006), covered a broad range of topics concerned with research in high magnetic fields: (1) magnetism, (2) strongly correlated electron systems, (3) superconductors, (4) metals and metallic nanostructures, (5) molecular systems, (6) semiconductors, (7) field effects on non-magnetic systems, (8) neutron and x-ray experiments in high magnetic fields, (9) magnet technology, (10) measurement techniques in high magnetic fields, and (11) high field facilities. First of all we would like to express sincere thanks to the Yamada Science Foundation for their support and encouragement. We would like to thank all the members of the International Advisory Committee and the Program Committee for their collaboration. The conference was organized as usual with oral sessions having both invited and contributed talks and poster sessions. The technical program started on the morning of Thursday 17 August, with a tutorial lecture by Professor M von Ortenberg. The special posters were invited to introduce recent activities and up-to-date equipment of 17 high field facilities in the world. On the Friday evening, we had a banquet at Sendai City Museum for the history and culture of Sendai, with Emeritus Professor M Date (a Chairman for the first conference in Osaka) and many other guests. The conference was closed with a talk by Professor F Herlach on the afternoon of Saturday 19 August. We heard with great pleasure the announcement from Professor J Wosnitza that next RHMF will be held in Dresden in 2009. This conference had 197 participants, 9 of which were women and 62 were from 17 countries other than Japan. Finally we would like to thank all the participants and authors for their contributions to the success of RHMF2006. Mitsuhiro Motokawa Chairperson, RHMF2006

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jung, Ho Won; Tschaplinski, Timothy J; Wang, Lin

Upon local infection, plants possess inducible systemic defense responses against their natural enemies. Bacterial infection results in the accumulation to high levels of the mobile metabolite C9-dicarboxylic acid azelaic acid in the vascular sap of Arabidopsis. Azelaic acid confers local and systemic resistance against Pseudomonas syringae. The compound primes plants to strongly accumulate salicylic acid (SA), a known defense signal, upon infection. Mutation of a gene induced by azelaic acid (AZI1) results in the specific loss in plants of systemic immunity triggered by pathogen or azelaic acid and of the priming of SA induction. AZI1, a predicted secreted protein, ismore » also important for generating vascular sap that confers disease resistance. Thus, azelaic acid and AZI1 comprise novel components of plant systemic immunity involved in priming defenses.« less

Identification of cis-elements conferring high levels of gene expression in non-green plastids.

PubMed

Zhang, Jiang; Ruf, Stephanie; Hasse, Claudia; Childs, Liam; Scharff, Lars B; Bock, Ralph

2012-10-01

Although our knowledge about the mechanisms of gene expression in chloroplasts has increased substantially over the past decades, next to nothing is known about the signals and factors that govern expression of the plastid genome in non-green tissues. Here we report the development of a quantitative method suitable for determining the activity of cis-acting elements for gene expression in non-green plastids. The in vivo assay is based on stable transformation of the plastid genome and the discovery that root length upon seedling growth in the presence of the plastid translational inhibitor kanamycin is directly proportional to the expression strength of the resistance gene nptII in transgenic tobacco plastids. By testing various combinations of promoters and translation initiation signals, we have used this experimental system to identify cis-elements that are highly active in non-green plastids. Surprisingly, heterologous expression elements from maize plastids were significantly more efficient in conferring high expression levels in root plastids than homologous expression elements from tobacco. Our work has established a quantitative method for characterization of gene expression in non-green plastid types, and has led to identification of cis-elements for efficient plastid transgene expression in non-green tissues, which are valuable tools for future transplastomic studies in basic and applied research. © 2012 The Authors. The Plant Journal © 2012 Blackwell Publishing Ltd.

RAD18 mediates resistance to ionizing radiation in human glioma cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xie, Chen; Wang, Hongwei; Cheng, Hongbin

Highlights: • RAD18 is an important mediator of the IR-induced resistance in glioma cell lines. • RAD18 overexpression confers resistance to IR-mediated apoptosis. • The elevated expression of RAD18 is associated with recurrent GBM who underwent IR therapy. - Abstract: Radioresistance remains a major challenge in the treatment of glioblastoma multiforme (GBM). RAD18 a central regulator of translesion DNA synthesis (TLS), has been shown to play an important role in regulating genomic stability and DNA damage response. In the present study, we investigate the relationship between RAD18 and resistance to ionizing radiation (IR) and examined the expression levels of RAD18more » in primary and recurrent GBM specimens. Our results showed that RAD18 is an important mediator of the IR-induced resistance in GBM. The expression level of RAD18 in glioma cells correlates with their resistance to IR. Ectopic expression of RAD18 in RAD18-low A172 glioma cells confers significant resistance to IR treatment. Conversely, depletion of endogenous RAD18 in RAD18-high glioma cells sensitized these cells to IR treatment. Moreover, RAD18 overexpression confers resistance to IR-mediated apoptosis in RAD18-low A172 glioma cells, whereas cells deficient in RAD18 exhibit increased apoptosis induced by IR. Furthermore, knockdown of RAD18 in RAD18-high glioma cells disrupts HR-mediated repair, resulting in increased accumulation of DSB. In addition, clinical data indicated that RAD18 was significantly higher in recurrent GBM samples that were exposed to IR compared with the corresponding primary GBM samples. Collectively, our findings reveal that RAD18 may serve as a key mediator of the IR response and may function as a potential target for circumventing IR resistance in human GBM.« less

The Company and Its Role in the Production of Qualifications: The Constitution and Development of Middle-Level Qualifications in Germany and France--A Comparison.

ERIC Educational Resources Information Center

CEDEFOP Flash, 1990

1990-01-01

This paper summarizes a conference on the development of midlevel technical personnel in Germany and France. The proceedings of the conference were divided into five presentations: (1) an introduction to the subject of the project and the conference; (2) a comparative presentation of the origins and development of educational training routes in…

PREFACE: 1st International Workshop on Theoretical and Computational Physics: Condensed Matter, Soft Matter and Materials Physics & 38th National Conference on Theoretical Physics

NASA Astrophysics Data System (ADS)

2014-09-01

This volume contains selected papers presented at the 38th National Conference on Theoretical Physics (NCTP-38) and the 1st International Workshop on Theoretical and Computational Physics: Condensed Matter, Soft Matter and Materials Physics (IWTCP-1). Both the conference and the workshop were held from 29 July to 1 August 2013 in Pullman hotel, Da Nang, Vietnam. The IWTCP-1 was a new activity of the Vietnamese Theoretical Physics Society (VTPS) organized in association with the 38th National Conference on Theoretical Physics (NCTP-38), the most well-known annual scientific forum dedicated to the dissemination of the latest development in the field of theoretical physics within the country. The IWTCP-1 was also an External Activity of the Asia Pacific Center for Theoretical Physics (APCTP). The overriding goal of the IWTCP is to provide an international forum for scientists and engineers from academia to share ideas, problems and solution relating to the recent advances in theoretical physics as well as in computational physics. The main IWTCP motivation is to foster scientific exchanges between the Vietnamese theoretical and computational physics community and world-wide scientists as well as to promote high-standard level of research and education activities for young physicists in the country. About 110 participants coming from 10 countries participated in the conference and the workshop. 4 invited talks, 18 oral contributions and 46 posters were presented at the conference. In the workshop we had one keynote lecture and 9 invited talks presented by international experts in the fields of theoretical and computational physics, together with 14 oral and 33 poster contributions. The proceedings were edited by Nguyen Tri Lan, Trinh Xuan Hoang, and Nguyen Ai Viet. We would like to thank all invited speakers, participants and sponsors for making the conference and the workshop successful. Nguyen Ai Viet Chair of NCTP-38 and IWTCP-1

Social status level and dimension interactively influence person evaluations indexed by P300s.

PubMed

Gyurovski, Ivo; Kubota, Jennifer; Cardenas-Iniguez, Carlos; Cloutier, Jasmin

2018-06-01

Functional neuroimaging research suggests that status-based evaluations may not solely depend on the level of social status but also on the conferred status dimension. However, no reports to date have studied how status level and dimension shape early person evaluations. To explore early status-based person evaluations, event-related brain potential data were collected from 29 participants while they indicated the status level and dimension of faces that had been previously trained to be associated with one of four status types: high moral, low moral, high financial, or low financial. Analysis of the P300 amplitude (previously implicated in social evaluation) revealed an interaction of status level and status dimension such that enhanced P300 amplitudes were observed in response to targets of high financial and low moral status relative to targets of low financial and high moral status. Implications of these findings are discussed in the context of our current understanding of status-based evaluation and, more broadly, of the processes by which person knowledge may shape person perception and evaluation.

Fourth High Alpha Conference, volume 1

NASA Technical Reports Server (NTRS)

1994-01-01

The goal of the Fourth High Alpha Conference was to focus on the flight validation of high angle-of-attack technologies and provide an in-depth review of the latest high angle-of-attack activities. Areas that were covered include: high angle-of-attack aerodynamics, propulsion and inlet dynamics, thrust vectoring, control laws and handling qualities, tactical utility, and forebody controls.

Animal Welfare Groups Press for Limits on High School Research.

ERIC Educational Resources Information Center

BioScience, 1979

1979-01-01

Discussions from the conference on "The Use of Animals in High School Biology Classes" are highlighted in this article. The list of science fair rules, which resulted from the conference, is included. (SA)

NASA Public Affairs and NUANCE Lab News Conference at Reno-Stead Airport.

NASA Image and Video Library

2016-10-19

News Conference following the test of Unmanned Aircraft Systems Traffic Management (UTM) technical capability Level 2 (TCL2) at Reno-Stead Airport, Nevada. Huy Tran, NASA Ames Aeronautics Director gives a NASA UTM Project Overview.

NASA Public Affairs and NUANCE Lab News Conference at Reno-Stead Airport.

NASA Image and Video Library

2016-10-19

News Conference following the test of Unmanned Aircraft Systems Traffic Management (UTM) technical capability Level 2 (TCL2) at Reno-Stead Airport, Nevada. Mark Baker, Director of Business Development, Nevada Institute of Autonomous Systems.

The use of online discussions for post-clinical conference.

PubMed

Berkstresser, Kristie

2016-01-01

Nurse educators, at every level of pre-licensure nursing education, are charged with developing critical thinking skills within their students. Post-clinical conference is one teaching strategy that nurse educators can employ to help promote the development of critical thinking skills in pre-licensure nursing students. However, traditional face-to-face post-clinical conference is marred with issues and concerns, as identified in the nursing education literature. An alternative to face-to-face post-clinical conference, asynchronous online learning environment, mitigates the issues and concerns associated with traditional post-clinical conference. Adult learning theory supports the use of asynchronous online learning environment because the asynchronous online learning environment promotes student-centered teaching strategy in place of teacher-centered learning, which by its nature traditional face-to-face post-clinical conference tends to support. Copyright © 2015 Elsevier Ltd. All rights reserved.

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance

PubMed Central

Bonhoure, Nicolas; Byrnes, Ashlee; Moir, Robyn D.; Hodroj, Wassim; Preitner, Frédéric; Praz, Viviane; Marcelin, Genevieve; Chua, Streamson C.; Martinez-Lopez, Nuria; Singh, Rajat; Moullan, Norman; Auwerx, Johan; Willemin, Gilles; Shah, Hardik; Hartil, Kirsten; Vaitheesvaran, Bhavapriya; Kurland, Irwin

2015-01-01

MAF1 is a global repressor of RNA polymerase III transcription that regulates the expression of highly abundant noncoding RNAs in response to nutrient availability and cellular stress. Thus, MAF1 function is thought to be important for metabolic economy. Here we show that a whole-body knockout of Maf1 in mice confers resistance to diet-induced obesity and nonalcoholic fatty liver disease by reducing food intake and increasing metabolic inefficiency. Energy expenditure in Maf1−/− mice is increased by several mechanisms. Precursor tRNA synthesis was increased in multiple tissues without significant effects on mature tRNA levels, implying increased turnover in a futile tRNA cycle. Elevated futile cycling of hepatic lipids was also observed. Metabolite profiling of the liver and skeletal muscle revealed elevated levels of many amino acids and spermidine, which links the induction of autophagy in Maf1−/− mice with their extended life span. The increase in spermidine was accompanied by reduced levels of nicotinamide N-methyltransferase, which promotes polyamine synthesis, enables nicotinamide salvage to regenerate NAD+, and is associated with obesity resistance. Consistent with this, NAD+ levels were increased in muscle. The importance of MAF1 for metabolic economy reveals the potential for MAF1 modulators to protect against obesity and its harmful consequences. PMID:25934505

Vaccine-induced protection against anthrax in cheetah (Acinonyx jubatus) and black rhinoceros (Diceros bicornis).

PubMed

Turnbull, P C B; Tindall, B W; Coetzee, J D; Conradie, C M; Bull, R L; Lindeque, P M; Huebschle, O J B

2004-09-03

Institution of a policy of vaccination in endangered species with a vaccine not previously administered to it cannot be undertaken lightly. This applies even more in the case of cheetah (Acinonyx jubatus) with their unusually monomorphic gene pool and the potential restrictions this places on their immune responses. However, the recently observed mortalities from anthrax in these animals in the Etosha National Park, Namibia, made it imperative to evaluate vaccination. Black rhinoceros (Diceros bicornis), another endangered species in the park, have been vaccinated for over three decades but the effectiveness of this has never been evaluated. Passive protection tests in A/J mice using sera from 12 cheetahs together with enzyme immunoassay indicated that cheetah are able to mount seemingly normal primary and secondary humoral immune responses to the Sterne 34F2 live spore livestock vaccine. Overall protection rates in mice injected with the sera rose and fell in concert with rises and declines in antibody titres, although fine analysis showed that the correlation between titre and protection was complex. Once a high level of protection (96% of mice 1 month after a second booster in the cheetahs) had been achieved, the duration of substantial protection appeared good (60% of the mice 5 months after the second booster). Protection conferred on mice by sera from three of four vaccinated rhino was almost complete, but, obscurely, none of the mice receiving serum from the fourth rhino were protected. Sera from three park lions with naturally acquired high antibody titres, included as controls, also conferred high levels of protection. For the purposes of wildlife management, the conclusions were that vaccination of cheetah with the standard animal anthrax vaccine causes no observable ill effect in the animals and does appear to confer protective immunity. At least one well-separated booster does appear to be desirable. Vaccination of rhino also appears to be justified from the limited data obtained.

Tidewater Multi-Service Market Perspectives: Driving change through MTF and market-level assessment and strategies

DTIC Science & Technology

2011-01-25

The Quadruple Aim: Working Together, Achieving Success 2011 Military Health System Conference Driving change through MTF and market -level assessment...and strategies Tidewater Multi-Service Market Perspectives January 25, 2011 Rear Admiral A. Stocks, MC, USN Colonel E. Stone, MC, USAF...Colonel K. Gausman, NC, USA 1 Military Health System Conference Tidewater Multi-Service Market Report Documentation Page Form ApprovedOMB No. 0704-0188

Support for the 38th International Conference on High Energy Physics, 3-10 August 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Young-Kee

The 38th International Conference on High Energy Physics (ICHEP) held in Chicago from August 3 to 10, 2016 was for physicists from around the world to gather to share the latest advancements in particle physics, astrophysics/cosmology, and accelerator science and to discuss plans for major future facilities. DOE funding provided partial support for space rental audio-visual services for scientific presentations at the conference.

PREFACE: 12th Conference on Recent Developments in Gravity (NEB XII)

NASA Astrophysics Data System (ADS)

Christodoulakis, Theodosios; Vagenas, Elias C.

2007-06-01

Continuing the 24 year old tradition, one of the Greek relativistic groups, this time the Relativity Group of the Physics Department of the University of Athens, organized the 12th Conference of the series "Recent Developments in Gravity" (NEB XII). This time NEB took place at Nafplio, Greece, from Thursday 29 June to Sunday 2 July, 2006. The Conference was attended by more than 100 participants, more than 50% of whom were relativists from abroad (both Greek and other nationalities). This signifies a tendency of the last few Conferences to open up the Greek Relativity Conference to the international scientific community. Actually, many notable members of the relativistic community all over the globe showed particular interest in coming to Nafplio, and spend four relaxed days in a nice sunny and historical place, presenting the results of their more recent work and discussing it with colleagues and students from Greece. The NEB XII Conference covered various aspects of gravitational physics: Relativistic Astrophysics, Mathematical Relativity, Quantum Gravity, and Cosmology. Although the program was rather heavy and for the first time we had parallel sessions running in the afternoons, the wonderful weather (apart from the last afternoon when it rained heavily) and the beauty of Nafplio helped the organizers offer the participants a warm, pleasant, and creative time. According to most attendees, their impression was more than good, not only with respect to the hospitable environment, but with respect to the high level of talks as well. We hope the next Conference, which will be organized by the Relativity Group of the Aristotle University of Thessaloniki in the summer of 2008, will raise the standards of the Conference even higher, thus further establishing our Conference as a notable Conference in the Relativistic community all over the world. Finally, we would like to thank the Gravitational Physics Section of the European Physical Society (GPS/EPS), ILIAS/ENTApP, the Hellenic Ministry for Education and Religion, Athens University and ETHNIKI Insurance Co. that financially supported the Conference. We also thank the members of the Local Organizing Committee and the International Scientific Committee. Editors Theodosios I Christodoulakis Elias C Vagenas International Scientific Committee Kokkotas, K (University of Thessaloniki, Greece) Schäfer, G (University of Jena, Germany) Zanelli, J (CECS, Chile) Local Organizing Committee Christodoulakis, T I (University of Athens) Chairman Apostolatos, T (University of Athens) Stavrinos, P (University of Athens) Grammenos, T (University of Thessaly) Zoupas, A (University of Athens and University of Thessaly) Vagenas, E C (University of Athens)

NASA Public Affairs and NUANCE Lab News Conference at Reno-Stead Airport.

NASA Image and Video Library

2016-10-19

News Conference following the test of Unmanned Aircraft Systems Traffic Management (UTM) technical capability Level 2 (TCL2) at Reno-Stead Airport, Nevada. Tom Wilczek, Aerospace and Defence industry representative and Nevada Govenor's Office of Economic Development.

Real Audiences and Contexts for LD Writers.

ERIC Educational Resources Information Center

Stires, Susan

1983-01-01

The process/conference model of writing instruction is described for intermediate-level learning disabled students. Students proceed through several stages of writing (rehearsal, drafting, revising, editing, and rewriting) during which they have conferences with the teacher and eventually publish their writing. (CL)

NASA Public Affairs and NUANCE Lab News Conference at Reno-Stead Airport.

NASA Image and Video Library

2016-10-19

News Conference following the test of Unmanned Aircraft Systems Traffic Management (UTM) technical capability Level 2 (TCL2) at Reno-Stead Airport, Nevada. Maril Mora, President / CEO of the Reno -Tahoe Airport Authority welcomes NASA and Partners.

Levels of airborne dust in furniture making factories in the High Wycombe area

PubMed Central

Hounam, R. F.; Williams, J.

1974-01-01

Hounam, R. F. and Williams, J. (1974).British Journal of Industrial Medicine,31, 1-9. Levels of airborne dust in furniture making factories in the High Wycombe area. A dust survey was carried out in five furniture making factories in, or in the vicinity of, High Wycombe. The results, which are among the first to be reported for the United Kingdom, have provided information on the concentrations and size distributions of airborne dust to which wood machinists are currently exposed. Although measured concentrations covered a wide range, the average concentration was similar to the threshold limit value of 5 mg m-3 provisionally recommended by the American Conference of Governmental Industrial Hygienists. A high proportion by mass of the airborne dust was of a size which will be deposited in the nasal passages on inhalation. Images PMID:4821408

PREFACE: 1st International Conference in Applied Physics and Materials Science

NASA Astrophysics Data System (ADS)

2015-06-01

We are delighted to come up with thirty two (32) contributed research papers in these proceedings, focusing on Materials Science and Applied Physics as an output of the 2013 International Conference in Applied Physics and Materials Science (ICAMS2013) held on October 22-24, 2013 at the Ateneo de Davao University, Davao City, Philippines. The conference was set to provide a high level of international forum and had brought together leading academic scientists, industry professionals, researchers and scholars from universities, industries and government agencies who have shared their experiences, research results and discussed the practical challenges encountered and the solutions adopted as well as the advances in the fields of Applied Physics and Materials Science. This conference has provided a wide opportunity to establish multidisciplinary collaborations with local and foreign experts. ICAMS2013, held concurrently with 15th Samahang Pisika ng Visayas at Mindanao (SPVM) National Physics Conference and 2013 International Meeting for Complex Systems, was organized by the Samahang Pisika ng Visayas at Mindanao (Physics Society of Visayas and Mindanao) based in MSU-Iligan Institute of Technology, Iligan City, Philippines. The international flavor of converging budding researchers and experts on Materials Science and Applied Physics was the first to be organized in the 19 years of SPVM operation in the Philippines. We highlighted ICAMS2013 gathering by the motivating presence of Dr. Stuart Parkin, a British Physicist, as one of our conference's plenary speakers. Equal measures of gratitude were also due to all other plenary speakers, Dr. Elizabeth Taylor of Institute of Physics (IOP) in London, Dr. Surya Raghu of Advanced Fluidics in Maryland, USA and Prof. Hitoshi Miyata of Niigata University, Japan, Prof. Djulia Onggo of Institut Teknologi Bandung, Indonesia, and Dr. Hironori Katagiri of Nagaoka National College of Technology, Japan. The warm hospitality of the host university, Ateneo de Davao University, Davao City, Philippines blended with the overwhelming enthusiasm of the conference speakers, participants, and the unwavering support of the conference sponsors and donors and the administration of the MSU-Iligan Institute of Technology, Iligan City, Philippines, all have brought realization to the production of these proceedings.

Teaching of Psychology: Ideas and Innovations. Proceedings of the Annual Conference on Undergraduate Teaching of Psychology (8th, Ellenville, New York, March 16-18, 1994).

ERIC Educational Resources Information Center

Hartog, Sandra B., Ed.; Levine, Judith R., Ed.

This publications presents 20 papers from a conference on innovations in teaching psychology at the college level along with a conference program that lists and describes all presentations. The papers are "They Can't Learn When They Don't Know How: Teaching Statistics Using a Learning to Learn Model" (Beverly Rolker-Dolinsky and Donna Qualters);…

Research in Vocational and Technical Education. (Proceedings of a Conference, June 10-11, 1966).

ERIC Educational Resources Information Center

Quirk, Cathleen, Ed.; Sheehan, Carol, Ed.

Selected high school, vocational school, community college, university, and industry personnel attended a conference to encourage research and dissemination of research findings in vocational and technical education. Studies reported are--(1) "Vocational Interests and Personality Patterns of High School Dropouts of High Ability," (2) "The…

7th National Conference on High-Occupancy Vehicle Systems : HOV systems in a new light

DOT National Transportation Integrated Search

1995-07-01

These proceedings of the 7th National Conference on High-Occupancy Vehicle Systems, held at the Bilmore Hotel in Los Angeles, California June 5-8, 1994 focus on the High Occupancy Vehicle (HOV) system in California; experiences from the Northridge Ea...

International High/Scope Conference Proceedings (Ypsilanti, Michigan, May 4-7, 1999).

ERIC Educational Resources Information Center

High/Scope Educational Research Foundation, Ypsilanti, MI.

These conference proceedings provide summaries of 61 presentations on various aspects of the High/Scope educational approach. In addition to summaries of special presentations on music and movement and on preschool "basics," topics addressed include: (1) High/Scope in the secondary setting; (2) classroom environment; (3) outdoor…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Juarez, A.

Los Alamos and Lawrence Livermore National Laboratories hosted the tenth annual Strategic Weapons in the 21st Century Conference (SW21) on 21 January 2016 to reinforce the national commitment to leadership and institutional excellence for nuclear deterrence. The event has been successful over the years in drawing together a diverse, high-level group of policy makers and experts from multiple disciplines to engage in informed dialogue on topics related to strategic weapons in national and international security.

First Draft of the act Programming Language

DTIC Science & Technology

2014-01-22

International Conference on, pages 1–15, 2013. [4] Yang Zhao, Jie Liu, and Edward A. Lee. A programming model for time - synchronized distributed real- time ...including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing...report is to document the first complete attempt at the design of a high-level programming language for timed systems called act. We define the lexical

Long-Term Mental Health among Low-Income, Minority Women Following Exposure to Multiple Natural Disasters in Early and Late Adolescence Compared to Adulthood

ERIC Educational Resources Information Center

Jacobs, Marni B.; Harville, Emily W.

2015-01-01

Background: High impact experiences following a natural disaster have been shown to influence later psychopathology. Individual-level factors such as age may also contribute to a disaster's impact on mental health, though it is unclear whether young age confers a protective effect or represents a period of increased risk as compared to adulthood.…

Trehalose accumulation enhances tolerance of Saccharomyces cerevisiae to acetic acid.

PubMed

Yoshiyama, Yoko; Tanaka, Koichi; Yoshiyama, Kohei; Hibi, Makoto; Ogawa, Jun; Shima, Jun

2015-02-01

Trehalose confers protection against various environmental stresses on yeast cells. In this study, trehalase gene deletion mutants that accumulate trehalose at high levels showed significant stress tolerance to acetic acid. The enhancement of trehalose accumulation can thus be considered a target in the breeding of acetic acid-tolerant yeast strains. Copyright © 2014 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

High Frontier, The Journal for Space & Missile Professionals. Volume 5, Number 3

DTIC Science & Technology

2009-05-01

assume cyberspace responsibilities as directed by CORONA Fall. General Kehler has commanded at the squadron, group, and twice at the wing level, and has...October 2008 CORONA conference, the Air Force Space Command (AFSPC), in con- cert with Air Force Cyberspace Command (Provisional), is working diligently...which include electronic jamming equipment, computer viruses , directed-energy weapons, laser beam weapons, and non-directed-energy weapons

The relative contribution of target-site mutations in complex acaricide resistant phenotypes as assessed by marker assisted backcrossing in Tetranychus urticae.

PubMed

Riga, Maria; Bajda, Sabina; Themistokleous, Christos; Papadaki, Stavrini; Palzewicz, Maria; Dermauw, Wannes; Vontas, John; Leeuwen, Thomas Van

2017-08-23

The mechanisms underlying insecticide and acaricide resistance in insects and mites are often complex, including additive effects of target-site insensitivity, increased metabolism and transport. The extent to which target-site resistance mutations contribute to the resistance phenotype is, however, not well studied. Here, we used marker-assisted backcrossing to create 30 congenic lines carrying nine mutations (alone, or in combination in a few cases) associated with resistance to avermectins, pyrethroids, mite growth inhibitors and mitochondrial complex III inhibitors (QoI) in a polyphagous arthropod pest, the spider mite Tetranychus urticae. Toxicity tests revealed that mutations in the voltage-gated sodium channel, chitin synthase 1 and cytochrome b confer high levels of resistance and, when fixed in a population, these mutations alone can result in field failure of acaricide treatment. In contrast, although we confirmed the implication of mutations in glutamate-gated chloride channels in abamectin and milbemectin insensitivity, these mutations do not lead to the high resistance levels that are often reported in abamectin resistant strains of T. urticae. Overall, this study functionally validates reported target-site resistance mutations in T. urticae, by uncoupling them from additional mechanisms, allowing to finally investigate the strength of the conferred phenotype in vivo.

US objectives generally achieved at broadcasting satellite international conference. Improvements can help in future conferences

NASA Astrophysics Data System (ADS)

1984-08-01

The implementation of broadcasting satellite service for the Western Hemisphere was planned. Broadcasting satellites transmit television programs and other information services from Earth orbit to home or office antennas. At the request of the Senate Appropriations Subcommittee on Commerce, Justice, State and the Judiciary, GAO reviewed conference results as compared to established conference objectives and examined the interagency coordination of U.S. participation in this international conference. The United States basically achieved its two most important conference objectives: adopting a technically and procedurally flexible plan for broadcasting satellite service and obtaining a sufficient allocation of satellite orbit slots and frequencies to meet domestic needs. The U.S. was unable, however, to obtain agreement on adopting a maximum signal power level for satellites. The Department of State could improve its preparation, internal coordination, and administrative support for future international conferences and recommends actions to the Secretary of State to improve its international telecommunications activities.

Conference attendance does not correlate with emergency medicine residency in-training examination scores.

PubMed

Gene Hern, H; Wills, Charlotte; Alter, Harrison; Bowman, Steven H; Katz, Eric; Shayne, Philip; Vahidnia, Farnaz

2009-12-01

The residency review committee for emergency medicine (EM) requires residents to have greater than 70% attendance of educational conferences during residency training, but it is unknown whether attendance improves clinical competence or scores on the American Board of Emergency Medicine (ABEM) in-training examination (ITE). This study examined the relationship between conference attendance and ITE scores. The hypothesis was that greater attendance would correlate to a higher examination score. This was a multi-center retrospective cohort study using conference attendance data and examination results from residents in four large county EM residency training programs. Longitudinal multi-level models, adjusting for training site, U.S. Medical Licensing Examination (USMLE) Step 1 score, and sex were used to explore the relationship between conference attendance and in-training examination scores according to year of training. Each year of training was studied, as well as the overall effect of mean attendance as it related to examination score. Four training sites reported data on 405 residents during 2002 to 2008; 386 residents had sufficient data to analyze. In the multi-level longitudinal models, attendance at conference was not a significant predictor of in-training percentile score (coefficient = 0.005, 95% confidence interval [CI] = -0.053 to 0.063, p = 0.87). Score on the USMLE Step 1 examination was a strong predictor of ITE score (coefficient = 0.186, 95% CI = 0.155 to 0.217; p < 0.001), as was female sex (coefficient = 2.117, 95% CI = 0.987 to 3.25; p < 0.001). Greater conference attendance does not correlate with performance on an individual's ITE scores. Conference attendance may represent an important part of EM residency training but perhaps not of ITE performance. (c) 2009 by the Society for Academic Emergency Medicine.

XPLANE: Real-Time Awareness of Tactical Networks

DTIC Science & Technology

2012-09-01

Conference, pages 1–6. IEEE, 2010. [3] Nate Foster, Rob Harrison, Michael J. Freedman, Christopher Monsanto , Jennifer Rexford, Alec Story, and David...architecture for user-level packet capture. In Proceedings USENIX Winter 1993 Conference. ACM, 1993. [10] Christopher Monsanto , Nate Foster, Rob

NASA Public Affairs and NUANCE Lab News Conference at Reno-Stead Airport.

NASA Image and Video Library

2016-10-19

News Conference following the test of Unmanned Aircraft Systems Traffic Management (UTM) technical capability Level 2 (TCL2) at Reno-Stead Airport, Nevada. Parimal Kopardekar, NASA Ames Senior Engineer for Ait Transportation Systems gave an overview of UTM (Left).

NASA Public Affairs and NUANCE Lab News Conference at Reno-Stead Airport.

NASA Image and Video Library

2016-10-19

News Conference following the test of Unmanned Aircraft Systems Traffic Management (UTM) technical capability Level 2 (TCL2) at Reno-Stead Airport, Nevada. Parimal Kopardekar, NASA Ames Senior Engineer for Ait Transportation Systems gave an overview of UTM.

Places to Intervene to Make Complex Food Systems More Healthy, Green, Fair, and Affordable

PubMed Central

Malhi, Luvdeep; Karanfil, Özge; Merth, Tommy; Acheson, Molly; Palmer, Amanda; Finegood, Diane T.

2009-01-01

A Food Systems and Public Health conference was convened in April 2009 to consider research supporting food systems that are healthy, green, fair, and affordable. We used a complex systems framework to examine the contents of background material provided to conference participants. Application of our intervention-level framework (paradigm, goals, system structure, feedback and delays, structural elements) enabled comparison of the conference themes of healthy, green, fair, and affordable. At the level of system structure suggested actions to achieve these goals are fairly compatible, including broad public discussion and implementation of policies and programs that support sustainable food production and distribution. At the level of paradigm and goals, the challenge of making healthy and green food affordable becomes apparent as some actions may be in conflict. Systems thinking can provide insight into the challenges and opportunities to act to make the food supply more healthy, green, fair, and affordable. PMID:23173029

The use of pseudotypes to study viruses, virus sero-epidemiology and vaccination.

PubMed

Bentley, Emma M; Mather, Stuart T; Temperton, Nigel J

2015-06-12

The globalization of the world's economies, accompanied by increasing international travel, changing climates, altered human behaviour and demographics is leading to the emergence of different viral diseases, many of which are highly pathogenic and hence are considered of great public and animal health importance. To undertake basic research and therapeutic development, many of these viruses require handling by highly trained staff in BSL-3/4 facilities not readily available to the majority of the global R&D community. In order to circumvent the enhanced biosafety requirement, the development of non-pathogenic, replication-defective pseudotyped viruses is an effective and established solution to permit the study of many aspects of virus biology in a low containment biosafety level (BSL)-1/2 laboratory. Under the spectre of the unfolding Ebola crisis, this timely conference (the second to be organised by the Viral Pseudotype Unit, www.viralpseudotypeunit.info*) discusses the recent advances in pseudotype technology and how it is revolutionizing the study of important human and animal pathogens (human and avian influenza viruses, rabies/lyssaviruses, HIV, Marburg and Ebola viruses). Key topics addressed in this conference include the exploitation of pseudotypes for serology and serosurveillance, immunogenicity testing of current and next-generation vaccines and new pseudotype assay formats (multiplexing, kit development). The first pseudotype-focused Euroscicon conference organised by the Viral Pseudotype Unit was recently reviewed [1]. Copyright © 2015. Published by Elsevier Ltd.. All rights reserved.

Structure-based methods to predict mutational resistance to diarylpyrimidine non-nucleoside reverse transcriptase inhibitors.

PubMed

Azeem, Syeda Maryam; Muwonge, Alecia N; Thakkar, Nehaben; Lam, Kristina W; Frey, Kathleen M

2018-01-01

Resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) is a leading cause of HIV treatment failure. Often included in antiviral therapy, NNRTIs are chemically diverse compounds that bind an allosteric pocket of enzyme target reverse transcriptase (RT). Several new NNRTIs incorporate flexibility in order to compensate for lost interactions with amino acid conferring mutations in RT. Unfortunately, even successful inhibitors such as diarylpyrimidine (DAPY) inhibitor rilpivirine are affected by mutations in RT that confer resistance. In order to aid drug design efforts, it would be efficient and cost effective to pre-evaluate NNRTI compounds in development using a structure-based computational approach. As proof of concept, we applied a residue scan and molecular dynamics strategy using RT crystal structures to predict mutations that confer resistance to DAPYs rilpivirine, etravirine, and investigational microbicide dapivirine. Our predictive values, changes in affinity and stability, are correlative with fold-resistance data for several RT mutants. Consistent with previous studies, mutation K101P is predicted to confer high-level resistance to DAPYs. These findings were further validated using structural analysis, molecular dynamics, and an enzymatic reverse transcription assay. Our results confirm that changes in affinity and stability for mutant complexes are predictive parameters of resistance as validated by experimental and clinical data. In future work, we believe that this computational approach may be useful to predict resistance mutations for inhibitors in development. Published by Elsevier Inc.

Using High-Content Imaging to Analyze Toxicological Tipping ...

EPA Pesticide Factsheets

Presentation at International Conference on Toxicological Alternatives & Translational Toxicology (ICTATT) held in China and Discussing the possibility of using High Content Imaging to Analyze Toxicological Tipping Points Slide Presentation at International Conference on Toxicological Alternatives & Translational Toxicology (ICTATT) held in China and Discussing the possibility of using High Content Imaging to Analyze Toxicological Tipping Points

International High/Scope Registry Conference Proceedings (Ypsilanti, Michigan, May 7-10, 1997).

ERIC Educational Resources Information Center

High/Scope Educational Research Foundation, Ypsilanti, MI.

These conference proceedings provide summaries of 66 presentations on various aspects of the High/Scope educational approach. In addition to summaries of special presentations on music and movement, topics addressed include: (1) observation/feedback strategies; (2) adult-child interaction; (3) songs in daily routines; (4) High/Scope for infants…

Guidance and control 1991; Proceedings of the Annual Rocky Mountain Guidance and Control Conference, Keystone, CO, Feb. 2-6, 1991

NASA Astrophysics Data System (ADS)

Culp, Robert D.; McQuerry, James P.

1991-07-01

The present conference on guidance and control encompasses advances in guidance, navigation, and control, storyboard displays, approaches to space-borne pointing control, international space programs, recent experiences with systems, and issues regarding navigation in the low-earth-orbit space environment. Specific issues addressed include a scalable architecture for an operational spaceborne autonavigation system, the mitigation of multipath error in GPS-based attitude determination, microgravity flight testing of a laboratory robot, and the application of neural networks. Other issues addressed include image navigation with second-generation Meteosat, Magellan star-scanner experiences, high-precision control systems for telescopes and interferometers, gravitational effects on low-earth orbiters, experimental verification of nanometer-level optical pathlengths, and a flight telerobotic servicer prototype simulator. (For individual items see A93-15577 to A93-15613)

Degrees Conferred by Schools and Colleges of Pharmacy, 1987-1988.

ERIC Educational Resources Information Center

Penna, Richard P.; Sherman, Michael S.

1989-01-01

Data and statistics, gathered by the American Association of Colleges of Pharmacy, on the degrees conferred by U.S. pharmacy schools are presented. Data on entry level degrees, post-baccalaureate PharmD, graduate degrees, gender, and ethnic minorities are analyzed. (Author/MLW)

The net effect: spanning diseases, crossing borders—highlights from the fourth triennial APCA conference and annual HPCA conference for palliative care

PubMed Central

Downing, J; Namisango, E; Kiyange, F; Luyirika, E; Gwyther, L; Enarson, S; Kampi, J; Sithole, Z; Kemigisha-Ssali, E; Masclee, M; Mukasa, I

2013-01-01

The African Palliative Care Association (APCA) jointly hosted its triennial palliative care conference for Africa with the Hospice and Palliative Care Association of South Africa (HPCA) on 17–20 September 2013 in Johannesburg, South Africa. At the heart of the conference stood a common commitment to see patient care improved across the continent. The theme for the conference, ‘The Net Effect: Spanning Diseases, Crossing Borders’, reflected this joint vision and the drive to remember the ‘net effect’ of our work in palliative care—that is, the ultimate impact of the care that we provide for our patients and their families across the disease and age spectrum and across the borders of African countries. The conference, held in Johannesburg, brought together 471 delegates from 34 countries. The key themes and messages from the conference are encapsulated in ten ‘C’s of commitment to political will and support at the highest levels of governance; engaging national, regional, and international bodies; collaboration; diversity; palliative care for children; planning for human resources and capacity building; palliative care integration at all levels; developing an evidence base for palliative care in Africa; using new technologies; and improved quality of care. Participants found the conference to be a forum that challenged their understanding of the topics presented, as well as enlightening in terms of applying best practice in their own context. Delegates found a renewed commitment and passion for palliative care and related health interventions for children and adults with life-limiting and life-threatening illnesses within the region. This conference highlighted many of the developments in palliative care in the region and served as a unique opportunity to bring people together and serve as a lynchpin for palliative care provision and development in Africa. The delegates were united in the fact that together we can ‘span diseases,’ ‘cross borders,’ and realise the ‘African Dream’ for palliative care. PMID:24222787

2012 Gordon Research Conference on Microbial Stress Response, Schedule and Speaker/Poster Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Donohue, Timothy J.

2012-07-20

The Gordon Research Conference on Microbial Stress Response was held at Mount Holyoke College, South Hadley, Massachusetts, July 15-20, 2012. The Conference was well-attended with 180 participants. The 2012 Microbial Stress Responses Gordon Research Conference will provide a forum for the open reporting of recent discoveries on the diverse mechanisms employed by microbes to respond to stress. Approaches range from analysis at the molecular level (how are signals perceived and transmitted to change gene expression or function) to cellular and microbial community responses. Attached is a copy of the formal schedule and speaker program and the poster program.

The Medical Meaning of Reeducation for Germany: Contemporary Interpretation of Cultural and Institutional Change.

ERIC Educational Resources Information Center

Gerhardt, Uta

1997-01-01

Examines the approaches taken, the topics discussed, and the practical results of the 1944 conference, "Germany after the War." Organized and led by psychiatrist Richard Brickner, the conference focused on reeducation, institutional change, and psychological rehabilitation. The conference recommendations became highly relevant in the…

Fourth High Alpha Conference, volume 3

NASA Technical Reports Server (NTRS)

1994-01-01

Thie goal of this conference was to focus on the flight validation of high-angle-of-attack technologies and provide an in-depth review of the latest high-angle-of-attack activities. Areas covered include: (1) high-angle-of-attack aerodynamics; (2) propulsion and inlet dynamics; (3) thrust vectoring; (4) control laws and handling qualities; (5) tactical utility; and (6) forebody controls.

INSERVICE EDUCATION OF HIGH SCHOOL MATEMATICS TEACHER. (REPORT OF A CONFERENCE UNDER THE JOINT AUSPICES OF THE U.S. DEPT. OF HEALTH, EDUCATION, AND WELFARE AND THE NATIONAL COUNCIL OF TEACHERS OF MATHEMATICS, WASHINGTON, MARCH 17-19,1960).

ERIC Educational Resources Information Center

BROWN, KENNETH E.; SNADER, DANIEL W.

A CONFERENCE OF EDUCATORS WAS CALLED TO DEAL WITH THE NEED FOR IMPROVED HIGH SCHOOL MATHEMATICS TEACHING. SPECIFICALLY THE CONFERENCE CONSIDERED THE NEED FOR INSERVICE EDUCATION FOR TEACHING NEW IMPROVED PROGRAMS, THE KINDS OF PROGRAMS NOW IN PROGRESS, AND THE ROLE OF SCHOOL ADMINISTRATORS IN IMPLEMENTING THEM. INCLUDED ARE THE ADDRESSES AND THE…

Sequence Requirements of the 5-Enolpyruvylshikimate-3-phosphate Synthase 5[prime]-Upstream Region for Tissue-Specific Expression in Flowers and Seedlings.

PubMed Central

Benfey, PN; Takatsuji, H; Ren, L; Shah, DM; Chua, NH

1990-01-01

We have analyzed expression from deletion derivatives of the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) 5[prime]-upstream region in transgenic petunia flowers and seedlings. In seedlings, expression was strongest in root cortex cells and in trichomes. High-level expression in petals and in seedling roots was conferred by large (>500 base-pair) stretches of sequence, but was lost when smaller fragments were analyzed individually. This apparent requirement for extensive sequence suggests that combinations of cis-elements that are widely separated control tissue-specific expression from the EPSPS promoter. We have also used the high-level, petal-specific expression of the EPSPS promoter to change petal color in two mutant petunia lines. PMID:12354968

NASA Symposium 76. [opportunities for minorities and women in NASA programs

NASA Technical Reports Server (NTRS)

1976-01-01

New Mexico State University and the National Aeronautics and Space Administration hosted a symposium to promote NASA's efforts to increase the available pool of minority and women scientists and engineers to meet affirmative hiring goals. The conferences also provided an opportunity for key NASA officials to meet with appropriate officials of participating institutions to stimulate greater academic interest (among professors and students) in NASA's research and development programs. Minority aerospace scientists and engineers had opportunity to interact with the minority community, particulary with young people at the junior high, high school, and college levels. One aim was to raise minority community's level of understanding regarding NASA's Regional Distribution System for storage and retrieval of scientific and technical information.

Are functional foods redefining nutritional requirements?

PubMed

Jones, Peter J; Varady, Krista A

2008-02-01

Functional foods are increasing in popularity owing to their ability to confer health and physiological benefits. Nevertheless, the notion that functional foods improve health when providing nutrients at levels above and beyond existing recommended intakes is inconsistent with the definition of requirement. This disparity highlights the need for an alternative definition of nutrient requirement. The present objective is to examine distinctions between optimization of health, as defined by what we currently deem as required intakes, versus adding physiological benefit using bioactive agents found in functional foods. Presently, requirement is defined as the lowest amount of intake of a nutrient that will maintain a defined level of nourishment for a specific indicator of adequacy. In contrast, functional foods are described as ingredients that are not necessary for body function, yet provide added physiological benefit that confer better overall health. Plant sterols are one example of such an ingredient. Plant sterols lower plasma cholesterol concentrations, and may thus be considered essential nutrients in physiological situations where circulating cholesterol concentrations are high. Similarly, intakes of omega-3 fats beyond existing requirement may confer additional health benefits such as hypolipidemic and anti-diabetic effects. These examples underscore the inconsistencies between what is defined as a nutrient requirement versus what is identified as a health benefit of a functional food. Such discrepancies emphasize the need for a more all-encompassing definition of a nutrient requirement; that is, one that moves beyond the prevention of overt deficiency to encompass improved health and disease risk reduction.

Conference Proceedings of Operational Loads Data Held at Sienna, Italy on 2-6 April 1984

DTIC Science & Technology

1984-08-01

new designs , e.g. highly agile, unconventional lay-outs, largely constructed of composite materials and heavily dependent upon active control ...significance of severe discrete gusts at low level, or the fatigue implications of flight control system design characteristics. For all these reasons, we... control technology is clearly going to have a major impact on military aircraft design . User pressure for greater structural efficiency is going to increase

The pineapple AcMADS1 promoter confers high level expression in tomato and arabidopsis flowering and fruiting tissues, but AcMADS1 does not complement the tomato LeMADS-RIN (rin) mutant

USDA-ARS?s Scientific Manuscript database

A previous EST study identified a MADS box transcription factor coding sequence, AcMADS1, that is strongly induced during non-climacteric pineapple fruit ripening. Phylogenetic analyses place the AcMADS1 protein in the same superclade as LeMADS-RIN, a master regulator of fruit ripening upstream of e...

Conference on Semi-Insulating III-V Materials (2nd), held 19-21 Apr 82, Evian (France),

DTIC Science & Technology

1983-02-28

Dist Special 19. KEY WORDS (Continue on reverse side If neceary mud Identity by block numb ) Semiconductor devices Field effect transitors Integrated...doped GaAs sub- 4 strates. The results showed no The catalog of defects includes statistically significant differ- vacancies, interstitials, anti...orientation also had high level profiles of GaAs active transconductance. In addition,the statistical scatter-uni-layers and their correlation to o m

Programming Environments for High Level Scientific Problem Solving. IFIP WG 2.5 Working Conference 6 Held in Karlsruhe, Germany on September 23 - 27, 1991

DTIC Science & Technology

1991-09-27

Springer Verlag (1989). (13] Hulshof , B.J.A. and van Hulzen, J.A.: "Automatic error cumulation control", Proceedir EUROSAM 󈨘 (J. Fitch. ed.), Springer...User’s Manual", Dept of Comp. Science. Univ. of Twente (In preparation). 268 [15] van Hulzen, J.A., Hulshof , B.J.A.. Gates, B.L. and van Heerwaarden, M.C

Export of the Virulence Factors from Shigella Flexneri and Characterization of the mxi loci

DTIC Science & Technology

1992-07-20

steps in Shigella pathogenesis. To identify temperature-regulated virulence genes on the plasmid, lacZ protein fusions were randomly generated in S ...this locus conferred the Mxi- phenotype and was found to affect virulence of S . flexneri at the level of invasion, which correlated with reduced...excretion of IpaC. Protease protection experiments indicated the presence of high intracellular reservoirs of Ipa proteins in wild-type S . flexneri as

PREFACE: NC-AFM 2005: Proceedings of the 8th International Conference on Non-Contact Atomic Force Microscopy

NASA Astrophysics Data System (ADS)

Reichling, M.; Mikosch, W.

2006-04-01

The 8th International Conference on Non-Contact Atomic Force Microscopy, held in Bad Essen, Germany, from 15 18th August 2005, attracted a record breaking number of participants presenting excellent contributions from a variety of scientific fields. This clearly demonstrated the high level of activity and innovation present in the community of NC-AFM researchers and the continuous growth of the field. The strongest ever participation of companies for a NC-AFM meeting is a sign for the emergence of new markets for the growing NC-AFM community; and the high standard of the products presented at the exhibition, many of them brand-new developments, reflected the unbroken progress in technology. The development of novel technologies and the sophistication of known techniques in research laboratories and their subsequent commercialization is still a major driving force for progress in this area of nanoscience. The conference was a perfect demonstration of how progress in the development of enabling technologies can readily be transcribed into basic research yielding fundamental insight with an impact across disciplines. The NC-AFM 2005 scientific programme was based on five cornerstones, each representing an area of vivid research and scientific progress. Atomic resolution imaging on oxide surfaces, which has long been a vision for the catalysis community, appears to be routine in several laboratories and after a period of demonstrative experiments NC-AFM now makes unique contributions to the understanding of processes in surface chemistry. These capabilities also open up new routes for the analysis of clusters and molecules deposited on dielectric surfaces where resolution limits are pushed towards the single atom level. Atomic precision manipulation with the dynamic AFM left the cradle of its infancy and flourishes in the family of bottom-up fabrication nanotechnologies. The systematic development of established and the introduction of new concepts of contrast formation allow the highly resolved measurement of a number of physical properties far beyond the determination of surface topography. The development of techniques allowing atomic resolution dynamic mode imaging in liquids pushes the door open for an atomic precision analysis of biological samples under physiological conditions. In each of these fields, the conference demonstrated cutting-edge results and also provided perspectives for the next steps on the roadmap of NC-AFM towards the development of its full extent. The conference in Bad Essen was made possible by the continuous dedication of the local management and we are most grateful to Frauke Riemann, Joachim Fontaine and the members of the supporting team for the smooth organization. We gratefully appreciate the financial support of the exhibitors, namely Anfatec, HALCYONICS, JEOL, LOT-Oriel, NanoMagnetics, NT-MDT, Omicron, Schaefer Technology, SURFACE, UNISOKU and the local sponsors which enabled us to provide free participation at the conference for ten promising young researchers who had submitted excellent contributions. It was a great pleasure for us to continue our most successful collaboration with Nanotechnology as our partner for the proceedings publication and we would like to thank Ian Forbes and the publishing team for the professional handling of the peer review and all production matters.

Factors associated with multidisciplinary case conference outcomes in children admitted to a regional hospital in Hong Kong with suspected child abuse: a retrospective case series with internal comparison.

PubMed

Lo, W C; Fung, G Pg; Cheung, P Ch

2017-10-01

In all cases of suspected child abuse, accurate risk assessment is vital to guide further management. This study examined the relationship between risk factors in a risk assessment matrix and child abuse case conference outcomes. Records of all children hospitalised at United Christian Hospital in Hong Kong for suspected child abuse from January 2012 to December 2014 were reviewed. Outcomes of the hospital abuse work-up as concluded in the Multi-Disciplinary Case Conference were categorised as 'established', 'high risk', or 'not established'. All cases of 'established' and 'high risk' were included in the positive case conference outcome group and all cases of 'not established' formed the comparison group. On the other hand, using the Risk Assessment Matrix developed by the California State University, Fresno in 1990, each case was allotted a matrix score of low, intermediate, or high risk in each of 15 matrix domains, and an aggregate matrix score was derived. The effect of individual matrix domain on case conference outcome was analysed. Receiver operating characteristic curve analysis was used to examine the relationship between case conference outcome and aggregate matrix score. In this study, 265 children suspected of being abused were included, with 198 in the positive case conference outcome group and 67 in the comparison group. Three matrix domains (severity and frequency of abuse, location of injuries, and strength of family support systems) were significantly associated with case conference outcome. An aggregate cut-off score of 23 yielded a sensitivity of 91.4% and specificity of 38.2% in relation to outcome of abuse categorisation. Risk assessment should be performed when handling suspected child abuse cases. A high aggregate score should arouse suspicion in all disciplines managing child abuse cases.

Degrees Conferred by Schools and Colleges of Pharmacy, 1986-1987.

ERIC Educational Resources Information Center

Penna, Richard P.; Sherman, Michael S.

1988-01-01

Data and statistics on the degrees conferred by U.S. pharmacy schools are presented. This report serves as an indicator of the pharmacy schools' output of pharmacy practitioners. Tables are analyzed by entry level degrees, postbaccalaureate PharmD, graduate degrees, gender, and ethnic minorities. (MLW)

NASA Public Affairs and NUANCE Lab News Conference at Reno-Stead Airport.

NASA Image and Video Library

2016-10-19

News Conference following the test of Unmanned Aircraft Systems Traffic Management (UTM) technical capability Level 2 (TCL2) at Reno-Stead Airport, Nevada. Joseph Rios, NASA Ames Aerospace Engineer and UTM Technical Lead, describes the purpose of the test and flight scenarios.

Fourth High Alpha Conference, volume 2

NASA Technical Reports Server (NTRS)

1994-01-01

The goal of the Fourth High Alpha Conference, held at the NASA Dryden Flight Research Center on July 12-14, 1994, was to focus on the flight validation of high angle of attack technologies and provide an in-depth review of the latest high angle of attack activities. Areas that were covered include high angle of attack aerodynamics, propulsion and inlet dynamics, thrust vectoring, control laws and handling qualities, and tactical utility.

Genome-Wide Tuning of Protein Expression Levels to Rapidly Engineer Microbial Traits.

PubMed

Freed, Emily F; Winkler, James D; Weiss, Sophie J; Garst, Andrew D; Mutalik, Vivek K; Arkin, Adam P; Knight, Rob; Gill, Ryan T

2015-11-20

The reliable engineering of biological systems requires quantitative mapping of predictable and context-independent expression over a broad range of protein expression levels. However, current techniques for modifying expression levels are cumbersome and are not amenable to high-throughput approaches. Here we present major improvements to current techniques through the design and construction of E. coli genome-wide libraries using synthetic DNA cassettes that can tune expression over a ∼10(4) range. The cassettes also contain molecular barcodes that are optimized for next-generation sequencing, enabling rapid and quantitative tracking of alleles that have the highest fitness advantage. We show these libraries can be used to determine which genes and expression levels confer greater fitness to E. coli under different growth conditions.

Proline accumulation in baker's yeast enhances high-sucrose stress tolerance and fermentation ability in sweet dough.

PubMed

Sasano, Yu; Haitani, Yutaka; Ohtsu, Iwao; Shima, Jun; Takagi, Hiroshi

2012-01-03

During bread-making processes, yeast cells are exposed to various baking-associated stresses. High-sucrose concentrations exert severe osmotic stress that seriously damages cellular components by generation of reactive oxygen species (ROS). Previously, we found that the accumulation of proline conferred freeze-thaw stress tolerance and the baker's yeast strain that accumulated proline retained higher-level fermentation abilities in frozen doughs than the wild-type strain. In this study, we constructed self-cloning diploid baker's yeast strains that accumulate proline. These resultant strains showed higher cell viability and lower intracellular oxidation levels than that observed in the wild-type strain under high-sucrose stress condition. Proline accumulation also enhanced the fermentation ability in high-sucrose-containing dough. These results demonstrate the usefulness of proline-accumulating baker's yeast for sweet dough baking. Copyright © 2011 Elsevier B.V. All rights reserved.

International High/Scope Registry Conference Proceedings (Ypsilanti, Michigan, May 8-11, 1996).

ERIC Educational Resources Information Center

High/Scope Educational Research Foundation, Ypsilanti, MI.

These conference proceedings provide summaries of 66 presentations on various aspects of the High/Scope active learning approach for high-risk students, as well as related topics. Topics addressed include: (1) real-life problem solving; (2) songs in daily routines; (3) open-ended art materials; (4) transition strategies; (5) recall ideas for…

Genomic Footprints of Selective Sweeps from Metabolic Resistance to Pyrethroids in African Malaria Vectors Are Driven by Scale up of Insecticide-Based Vector Control.

PubMed

Barnes, Kayla G; Weedall, Gareth D; Ndula, Miranda; Irving, Helen; Mzihalowa, Themba; Hemingway, Janet; Wondji, Charles S

2017-02-01

Insecticide resistance in mosquito populations threatens recent successes in malaria prevention. Elucidating patterns of genetic structure in malaria vectors to predict the speed and direction of the spread of resistance is essential to get ahead of the 'resistance curve' and to avert a public health catastrophe. Here, applying a combination of microsatellite analysis, whole genome sequencing and targeted sequencing of a resistance locus, we elucidated the continent-wide population structure of a major African malaria vector, Anopheles funestus. We identified a major selective sweep in a genomic region controlling cytochrome P450-based metabolic resistance conferring high resistance to pyrethroids. This selective sweep occurred since 2002, likely as a direct consequence of scaled up vector control as revealed by whole genome and fine-scale sequencing of pre- and post-intervention populations. Fine-scaled analysis of the pyrethroid resistance locus revealed that a resistance-associated allele of the cytochrome P450 monooxygenase CYP6P9a has swept through southern Africa to near fixation, in contrast to high polymorphism levels before interventions, conferring high levels of pyrethroid resistance linked to control failure. Population structure analysis revealed a barrier to gene flow between southern Africa and other areas, which may prevent or slow the spread of the southern mechanism of pyrethroid resistance to other regions. By identifying a genetic signature of pyrethroid-based interventions, we have demonstrated the intense selective pressure that control interventions exert on mosquito populations. If this level of selection and spread of resistance continues unabated, our ability to control malaria with current interventions will be compromised.

PREFACE: 6th Workshop on Infrared Spectroscopy and Microscopy with Accelerator-Based Sources (WIRMS11)

NASA Astrophysics Data System (ADS)

Lupi, Stefano; Perucchi, Andrea

2012-05-01

This volume of Journal of Physics: Conference Series is dedicated to a subset of papers related to the work presented at the 6th edition of the international Workshop on Infrared Spectroscopy and Microscopy with Accelerator-Based Sources (WIRMS), held in Trieste, Italy, September 4-8 2011. Previous editions of the conference were held in Porquerolles (France), Lake Tahoe (USA), Rathen (Germany), Awaji (Japan), and Banff (Canada). This edition was organized and chaired by Stefano Lupi (Roma La Sapienza) and co-chaired by Andrea Perucchi (Elettra), with the support of the Italian Synchrotron Light Laboratory ELETTRA, which was honored to host the WIRMS workshop in its tenth anniversary. The 6th WIRMS edition addressed several different topics, ranging from biochemistry to strongly correlated materials, from geology to conservation science, and from forensics to the study of cometary dusts. Representatives from the infrared scientific programs at synchrotron light sources and free-electron-laser facilities. This edition was attended by 88 participants, including representatives from the infrared scientific programs at synchrotron light sources and free-electron-laser facilities, who enjoyed the stimulating scientific presentations, several detailed discussions, and the beautiful weather and scenery of the Trieste gulf. Participants came from 16 different nations and four continents, including many young scientists, six of which were supported by the organizers. There were 45 scientific talks divided in 11 sessions: Facilities, Microspectroscopy (I, II, III), Time-Resolved Spectroscopies, Extreme Conditions, Condensed Matter, Near-Field, Imaging, THz Techniques and High-Resolution Spectroscopy. 37 posters were also presented at two very lively evening poster sessions. We would like to use the opportunity of writing this preface to thank all the participants of the workshop for the very high level of their scientific contribution and for the very friendly atmosphere, which were the most important keys to the success of the workshop. We also wish to thank all the companies (Bruker, Tydex, Spiricon, Allectra, Neaspec, Micos) and institutions (Sincrotrone Trieste, Sapienza University of Rome, EMS, INFN, CNR-IOM) sponsoring this event. We are indebted to the members of the International Advisory Committee for their valuable help in the difficult choosing of the invited speakers, and for more general advice on the conference organization and structuring. A special acknowledgment goes to the ELETTRA secretary staff, and in particular to Mariella Antonetti, who has been involved with the organization from the very beginning. The 7th WIRMS conference will be held in Melbourne (Australia). Our best wishes go to the organizers for a successful conference. Additional information on the conference can still be found on the conference website: http://www.elettra.trieste.it/events/2011/WIRMS/ A selection of the conference pictures is also available on Flickr: http://www.flickr.com/photos/sincrotronets/sets/72157627705743677/ Guest Editors Stefano Lupi and Andrea Perucchi Conference photograph The PDF also contains details of the Local Organizing Committee and International Advisory Committee and a list of Sponsors.

The European Physical Society Conference on High Energy Physics

NASA Astrophysics Data System (ADS)

2017-07-01

The European Physical Society Conference on High Energy Physics (EPS- HEP) is one of the major international conferences that review the field. It takes place every other year since 1971. It is organized by the High Energy and Particle Physics Division of the European Physical Society in cooperation with an appointed European Local Institute of Research or an internationally recognized University or Academy Body. EPS-HEP 2017 was held on 5-12 July in Venice, Italy at Palazzo del Cinema and Palazzo del Casinò, located in the Lido island. The conference has been organized by the Istituto Nazionale di Fisica Nucleare (INFN) and by the Department of Physics and Astronomy of the University of Padova. Editorial Board: Paolo Checchia, Mauro Mezzetto, Giuseppina Salente, Michele Doro, Livia Conti, Caterina Braggio, Chiara Sirignano, Andrea Dainese, Martino Margoni, Roberto Rossin, Pierpaolo Mastrolia, Patrizia Azzi, Enrico Conti, Marco Zanetti, Luca Martucci, Sofia Talas Lucano Canton.

What Every 17-Year Old Should Know about Planet Earth: The Report of a Conference of Educators and Geoscientists.

ERIC Educational Resources Information Center

Mayer, Victor J.; Armstrong, Ronald E.

1990-01-01

Presented are the background, conference charge, organization, and results from the "Planet Earth" conference. Discussed were the goals and concepts that every high school senior should know when completing a pre-college education. The issues, goals, and concepts of a curriculum are suggested. (KR)

Residential segregation and the survival of U.S. urban public hospitals.

PubMed

Ko, Michelle; Needleman, Jack; Derose, Kathryn Pitkin; Laugesen, Miriam J; Ponce, Ninez A

2014-06-01

Residential segregation is associated geographic disparities in access to care, but its impact on local health care policy, including public hospitals, is unknown. We examined the effects of racial residential segregation on U.S. urban public hospital closures from 1987 to 2007, controlling for hospital, market, and policy characteristics. We found that a high level of residential segregation moderated the protective effects of Black population composition, such that a high level of residential segregation, in combination with a high percentage of poor residents, conferred a higher likelihood of hospital closure. More segregated and poorer communities face disadvantages in access to care that may be compounded as a result of instability in the health care safety net. Policy makers should consider the influence of social factors such as residential segregation on the allocation of the safety net resources.

Book of Readings. Delta Pi Epsilon National Conference (Cleveland, OH, November 21-23, 2002).

ERIC Educational Resources Information Center

Delta Pi Epsilon Society, Little Rock, AR.

This document contains 17 papers from a national conference on promoting excellence in research and teaching for business. The following papers are included: "The Development of Innovative Learning Models for Modern Information Technology Professional Education" (Stephen C. Shih); "Entry-Level Information Services and Support…

Proceedings of the 1987 conference on tools for the simulation profession

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hawkins, R.; Klukis, K.

1987-01-01

This book covers the proceedings of the 1987 conference on tools for the simulation profession. Some of the topics are: SIMULACT: a generic tool for simulating distributed systems; ESL language simulation of spacecraft batteries; and Trends in global cadmium levels from increased use of fossil fuels.

Recent Initiatives in Labor-Management Cooperation.

ERIC Educational Resources Information Center

National Center for Productivity and Quality of Working Life, Washington, DC.

This report draws on a series of conferences held to develop guides for labor-management cooperation at the plant level. These included six recent initiatives conferences held in cooperation with State University Institutes of Industrial Relations and the Federal Mediation and Conciliation Service (FMCS) and a seventh sponsored by the Commission…

Peer-review for selection of oral presentations for conferences: Are we reliable?

PubMed

Deveugele, Myriam; Silverman, Jonathan

2017-11-01

Although peer-review for journal submission, grant-applications and conference submissions has been called 'a counter- stone of science', and even 'the gold standard for evaluating scientific merit', publications on this topic remain scares. Research that has investigated peer-review reveals several issues and criticisms concerning bias, poor quality review, unreliability and inefficiency. The most important weakness of the peer review process is the inconsistency between reviewers leading to inadequate inter-rater reliability. To report the reliability of ratings for a large international conference and to suggest possible solutions to overcome the problem. In 2016 during the International Conference on Communication in Healthcare, organized by EACH: International Association for Communication in Healthcare, a calibration exercise was proposed and feedback was reported back to the participants of the exercise. Most abstracts, as well as most peer-reviewers, receive and give scores around the median. Contrary to the general assumption that there are high and low scorers, in this group only 3 peer-reviewers could be identified with a high mean, while 7 has a low mean score. Only 2 reviewers gave only high ratings (4 and 5). Of the eight abstracts included in this exercise, only one abstract received a high mean score and one a low mean score. Nevertheless, both these abstracts received both low and high scores; all other abstracts received all possible scores. Peer-review of submissions for conferences are, in accordance with the literature, unreliable. New and creative methods will be needed to give the participants of a conference what they really deserve: a more reliable selection of the best abstracts. More raters per abstract improves the inter-rater reliability; training of reviewers could be helpful; providing feedback to reviewers can lead to less inter-rater disagreement; fostering negative peer-review (rejecting the inappropriate submissions) rather than a positive (accepting the best) could be fruitful for selecting abstracts for conferences. Copyright © 2017 Elsevier B.V. All rights reserved.

Multifunctional Structures for High-Energy Lightweight Load-Bearing Storage

NASA Technical Reports Server (NTRS)

Loyselle, Patricia L.

2018-01-01

This is a pull-up banner of the Multifunctional Structures for High-Energy Lightweight Load-bearing Storage (M-SHELLS) technology that will be on display at the SciTech Conference in January 2018. Efforts in Multifunctional Structures for High Energy Load-Bearing Storage (M-Shells) are pushing the boundaries of development for hybrid electric propulsion for future commercial aeronautical transport. The M-Shells hybrid material would serve as the power/energy storage of the vehicle and provide structural integrity, freeing up usable volume and mass typically occupied by bulky batteries. The ultimate goal is to demonstrate a system-level mass savings with a multifunctional structure with energy storage.

PREFACE: 12th Russia/CIS/Baltic/Japan Symposium on Ferroelectricity and 9th International Conference on Functional Materials and Nanotechnologies (RCBJSF-2014-FM&NT)

NASA Astrophysics Data System (ADS)

Sternberg, Andris; Grinberga, Liga; Sarakovskis, Anatolijs; Rutkis, Martins

2015-03-01

The joint International Symposium RCBJSF-2014-FM&NT successfully has united two international events - 12th Russia/CIS/Baltic/Japan Symposium on Ferroelectricity (RCBJSF-12) and 9th International Conference Functional Materials and Nanotechnologies (FM&NT-2014). The RCBJSF symposium is a continuation of series of meetings on ferroelectricity, the first of which took place in Novosibirsk (USSR) in 1976. FM&NT conferences started in 2006 and have been organized by Institute of Solid State Physics, University of Latvia in Riga. In 2012 the International program committee decided to transform this conference into a traveling Baltic State conference and the FM&NT-2013 was organized by the Institute of Physics, University of Tartu, Estonia. In 2014 the joint international symposium RCBJSF-2014-FM&NT was organized by the Institute of Solid State Physics, University of Latvia and was part of Riga - 2014, the European Capital of Culture event. The purpose of the joint Symposium was to bring together scientists, students and high-level experts in solid state physics, materials science, engineering and related disciplines. The number of the registered participants from 26 countries was over 350. During the Symposium 128 high quality scientific talks (5 plenary, 42 invited, 81 oral) and over 215 posters were presented. All presentations were divided into 4 parallel sessions according to 4 main topics of the Symposium: Ferroelectricity, including ferroelectrics and multiferroics, pyroelectrics, piezoelectrics and actuators, integrated ferroelectrics, relaxors, phase transitions and critical phenomena. Multifunctional Materials, including theory, multiscale and multiphenomenal material modeling and simulation, advanced inorganic, organic and hybrid materials. Nanotechnologies, including progressive methods, technologies and design for production, investigation of nano- particles, composites, structures, thin films and coatings. Energy, including perspective materials and technologies for renewable and hydrogen energy, fuel cells, photovoltaics, LEDs, OLEDs. Based on these reports, 48 papers are included in this volume of IOP Conference Series: Materials Science and Engineering. Additional information about RCBJSF-2014-FM&NT is available at the homepage http://www.fmnt.lu.lv. The Organizing Committee would like to thank all the speakers, contributors, session chairs, referees and other involved staff for their efforts in making the RCBJSF-2014-FM&NT successful. Sincerely, organizers of the event Andris Sternberg Liga Grinberga Anatolijs Sarakovskis Martins Rutkis

Assessment of winter air pollution episodes using long-range transport modeling in Hangzhou, China, during World Internet Conference, 2015.

PubMed

Ni, Zhi-Zhen; Luo, Kun; Zhang, Jun-Xi; Feng, Rui; Zheng, He-Xin; Zhu, Hao-Ran; Wang, Jing-Fan; Fan, Jian-Ren; Gao, Xiang; Cen, Ke-Fa

2018-05-01

A winter air pollution episode was observed in Hangzhou, South China, during the Second World Internet Conference, 2015. To study the pollution characteristics and underlying causes, the Weather Research and Forecasting with Chemistry model was used to simulate the spatial and temporal evolution of the pollution episode from December 8 to 19, 2015. In addition to scenario simulations, analysis of the atmospheric trajectory and synoptic weather conditions were also performed. The results demonstrated that control measures implemented during the week preceding the conference reduced the fine particulate matter (PM 2.5 ) pollution level to some extent, with a decline in the total PM 2.5 concentration in Hangzhou of 15% (7%-25% daily). Pollutant long-range transport, which occurred due to a southward intrusion of strong cold air driven by the Siberia High, led to severe pollution in Hangzhou on December 15, 2015, accounting for 85% of the PM 2.5 concentration. This study provides new insights into the challenge of winter pollution prevention in Hangzhou. For adequate pollution prevention, more regional collaborations should be fostered when creating policies for northern China. Copyright © 2018 Elsevier Ltd. All rights reserved.

Interfamily Transfer of Dual NB-LRR Genes Confers Resistance to Multiple Pathogens

PubMed Central

Narusaka, Mari; Kubo, Yasuyuki; Hatakeyama, Katsunori; Imamura, Jun; Ezura, Hiroshi; Nanasato, Yoshihiko; Tabei, Yutaka; Takano, Yoshitaka; Shirasu, Ken; Narusaka, Yoshihiro

2013-01-01

A major class of disease resistance (R) genes which encode nucleotide binding and leucine rich repeat (NB-LRR) proteins have been used in traditional breeding programs for crop protection. However, it has been difficult to functionally transfer NB-LRR-type R genes in taxonomically distinct families. Here we demonstrate that a pair of Arabidopsis (Brassicaceae) NB-LRR-type R genes, RPS4 and RRS1, properly function in two other Brassicaceae, Brassica rapa and Brassica napus, but also in two Solanaceae, Nicotiana benthamiana and tomato (Solanum lycopersicum). The solanaceous plants transformed with RPS4/RRS1 confer bacterial effector-specific immunity responses. Furthermore, RPS4 and RRS1, which confer resistance to a fungal pathogen Colletotrichum higginsianum in Brassicaceae, also protect against Colletotrichum orbiculare in cucumber (Cucurbitaceae). Importantly, RPS4/RRS1 transgenic plants show no autoimmune phenotypes, indicating that the NB-LRR proteins are tightly regulated. The successful transfer of two R genes at the family level implies that the downstream components of R genes are highly conserved. The functional interfamily transfer of R genes can be a powerful strategy for providing resistance to a broad range of pathogens. PMID:23437080

Acoustical case studies of three green buildings

NASA Astrophysics Data System (ADS)

Siebein, Gary; Lilkendey, Robert; Skorski, Stephen

2005-04-01

Case studies of 3 green buildings with LEED certifications that required extensive acoustical retrofit work to become satisfactory work environments for their intended user groups will be used to define areas where green building design concepts and acoustical design concepts require reconciliation. Case study 1 is an office and conference center for a city environmental education agency. Large open spaces intended to collect daylight through clerestory windows provided large, reverberant volumes with few acoustic finishes that rendered them unsuitable as open office space and a conference room/auditorium. Case Study 2 describes one of the first gold LEED buildings in the southeast whose primary design concepts were so narrowly focused on thermal and lighting issues that they often worked directly against basic acoustical requirements resulting in sound levels of NC 50-55 in classrooms and faculty offices, crosstalk between classrooms and poor room acoustics. Case study 3 is an environmental education and conference center with open public areas, very high ceilings, and all reflective surfaces made from wood and other environmentally friendly materials that result in excessive loudness when the building is used by the numbers of people which it was intended to serve.

PREFACE: 3rd International Conference on Mathematical Modeling in Physical Sciences (IC-MSQUARE 2014)

NASA Astrophysics Data System (ADS)

2015-01-01

The third International Conference on Mathematical Modeling in Physical Sciences (IC-MSQUARE) took place at Madrid, Spain, from Thursday 28 to Sunday 31 August 2014. The Conference was attended by more than 200 participants and hosted about 350 oral, poster, and virtual presentations. More than 600 pre-registered authors were also counted. The third IC-MSQUARE consisted of different and diverging workshops and thus covered various research fields where Mathematical Modeling is used, such as Theoretical/Mathematical Physics, Neutrino Physics, Non-Integrable Systems, Dynamical Systems, Computational Nanoscience, Biological Physics, Computational Biomechanics, Complex Networks, Stochastic Modeling, Fractional Statistics, DNA Dynamics, Macroeconomics etc. The scientific program was rather heavy since after the Keynote and Invited Talks in the morning, three parallel oral sessions and one poster session were running every day. However, according to all attendees, the program was excellent with high level of talks and the scientific environment was fruitful, thus all attendees had a creative time. We would like to thank the Keynote Speaker and the Invited Speakers for their significant contribution to IC-MSQUARE. We also would like to thank the Members of the International Advisory and Scientific Committees as well as the Members of the Organizing Committee.

Pigeonpea Hybrid-Proline-Rich Protein (CcHyPRP) Confers Biotic and Abiotic Stress Tolerance in Transgenic Rice

PubMed Central

Mellacheruvu, Sunitha; Tamirisa, Srinath; Vudem, Dashavantha Reddy; Khareedu, Venkateswara Rao

2016-01-01

In this study, we report the overexpression of Cajanus cajan hybrid-proline-rich protein encoding gene (CcHyPRP) in rice which resulted in increased tolerance to both abiotic and biotic stresses. Compared to the control plants, the transgenic rice lines, expressing CcHyPRP, exhibited high-level tolerance against major abiotic stresses, viz., drought, salinity, and heat, as evidenced by increased biomass, chlorophyll content, survival rate, root, and shoot growth. Further, transgenic rice lines showed increased panicle size and grain number compared to the control plants under different stress conditions. The CcHyPRP transgenics, as compared to the control, revealed enhanced activities of catalase and superoxide dismutase (SOD) enzymes and reduced malondialdehyde (MDA) levels. Expression pattern of CcHyPRP::GFP fusion-protein confirmed its predominant localization in cell walls. Moreover, the CcHyPRP transgenics, as compared to the control, exhibited increased resistance to the fungal pathogen Magnaporthe grisea which causes blast disease in rice. Higher levels of bZIP and endochitinase transcripts as well as endochitinase activity were observed in transgenic rice compared to the control plants. The overall results demonstrate the intrinsic role of CcHyPRP in conferring multiple stress tolerance at the whole-plant level. The multipotent CcHyPRP seems promising as a prime candidate gene to fortify crop plants for enhanced tolerance/resistance to different stress factors. PMID:26834756

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance.

PubMed

Bonhoure, Nicolas; Byrnes, Ashlee; Moir, Robyn D; Hodroj, Wassim; Preitner, Frédéric; Praz, Viviane; Marcelin, Genevieve; Chua, Streamson C; Martinez-Lopez, Nuria; Singh, Rajat; Moullan, Norman; Auwerx, Johan; Willemin, Gilles; Shah, Hardik; Hartil, Kirsten; Vaitheesvaran, Bhavapriya; Kurland, Irwin; Hernandez, Nouria; Willis, Ian M

2015-05-01

MAF1 is a global repressor of RNA polymerase III transcription that regulates the expression of highly abundant noncoding RNAs in response to nutrient availability and cellular stress. Thus, MAF1 function is thought to be important for metabolic economy. Here we show that a whole-body knockout of Maf1 in mice confers resistance to diet-induced obesity and nonalcoholic fatty liver disease by reducing food intake and increasing metabolic inefficiency. Energy expenditure in Maf1(-/-) mice is increased by several mechanisms. Precursor tRNA synthesis was increased in multiple tissues without significant effects on mature tRNA levels, implying increased turnover in a futile tRNA cycle. Elevated futile cycling of hepatic lipids was also observed. Metabolite profiling of the liver and skeletal muscle revealed elevated levels of many amino acids and spermidine, which links the induction of autophagy in Maf1(-/-) mice with their extended life span. The increase in spermidine was accompanied by reduced levels of nicotinamide N-methyltransferase, which promotes polyamine synthesis, enables nicotinamide salvage to regenerate NAD(+), and is associated with obesity resistance. Consistent with this, NAD(+) levels were increased in muscle. The importance of MAF1 for metabolic economy reveals the potential for MAF1 modulators to protect against obesity and its harmful consequences. © 2015 Bonhoure et al.; Published by Cold Spring Harbor Laboratory Press.

"High/Scope Supporting the Child, the Family, the Community": A Report of the Proceedings of the High/Scope Ireland Third Annual Conference, 12th October 2004, Newry, Northern Ireland

ERIC Educational Resources Information Center

Peyton, Lynne

2005-01-01

The third annual High/Scope Ireland Conference provided a forum for speakers workshop leaders and delegates from across Ireland, the UK, USA, Europe and South Africa to share their experiences of High/Scope in action. Research demonstrates that long term benefits for High/Scope participants include increased literacy rates, school success and…

Researching Complex and Multi-Level Workplace Factors Affecting Disability and Prolonged Sickness Absence.

PubMed

Kristman, Vicki L; Shaw, William S; Boot, Cécile R L; Delclos, George L; Sullivan, Michael J; Ehrhart, Mark G

2016-12-01

Purpose There is growing research evidence that workplace factors influence disability outcomes, but these variables reflect a variety of stakeholder perspectives, measurement tools, and methodologies. The goal of this article is to summarize existing research of workplace factors in relation to disability, compare this with employer discourse in the grey literature, and recommend future research priorities. Methods The authors participated in a year-long collaboration that ultimately led to an invited 3-day conference, "Improving Research of Employer Practices to Prevent Disability, held October 14-16, 2015, in Hopkinton, Massachusetts, USA. The collaboration included a topical review of the literature, group conference calls to identify key areas and challenges, drafting of initial documents, review of industry publications, and a conference presentation that included feedback from peer researchers and a question/answer session with a special panel of knowledge experts with direct employer experience. Results Predominant factors in the scientific literature were categorized as physical or psychosocial job demands, work organization and support, and workplace beliefs and attitudes. Employees experiencing musculoskeletal disorders in large organizations were the most frequently studied population. Research varied with respect to the basic unit of assessment (e.g., worker, supervisor, policy level) and whether assessments should be based on worker perceptions, written policies, or observable practices. The grey literature suggested that employers focus primarily on defining roles and responsibilities, standardizing management tools and procedures, being prompt and proactive, and attending to the individualized needs of workers. Industry publications reflected a high reliance of employers on a strict biomedical model in contrast to the more psychosocial framework that appears to guide research designs. Conclusion Assessing workplace factors at multiple levels, within small and medium-sized organizations, and at a more granular level may help to clarify generalizable concepts of organizational support that can be translated to specific employer strategies involving personnel, tools, and practices.

PREFACE: 4th Symposium on Prospects in the Physics of Discrete Symmetries (DISCRETE2014)

NASA Astrophysics Data System (ADS)

Di Domenico, Antonio; Mavromatos, Nick E.; Mitsou, Vasiliki A.; Skliros, Dimitri P.

2015-07-01

The DISCRETE 2014: Fourth Symposium in the Physics of Discrete Symmetries took place at King's College London, Strand Campus, London WC2R 2LS, from Tuesday, December 2 2014 till Saturday, December 6 2014. This is the fourth Edition of the DISCRETE conference series, which is a biannual event, having been held previously in Valencia (Discrete'08), Rome (Discrete2010) and Lisbon (Discrete2012). The topics covered at the DISCRETE series of conferences are: T, C, P, CP symmetries; accidental symmetries (B, L conservation); CPT symmetry, decoherence and entangled states, Lorentz symmetry breaking (phenomenology and current bounds); neutrino mass and mixing; implications for cosmology and astroparticle physics, dark matter searches; experimental prospects at LHC, new facilities. In DISCRETE 2014 we have also introduced two new topics: cosmological aspects of non-commutative space-times as well as PT symmetric Hamiltonians (non-Hermitian but with real eigenvalues), a topic that has wide applications in particle physics and beyond. The conference was opened by the King's College London Vice Principal on Research and Innovation, Mr Chris Mottershead, followed by a welcome address by the Chair of DISCRETE 2014 (Professor Nick E. Mavromatos). After these introductory talks, the scientific programme of the DISCRETE 2014 symposium started. Following the tradition of DISCRETE series of conferences, the talks (138 in total) were divided into plenary-review talks (25), invited research talks (50) and shorter presentations (63) — selected by the conveners of each session in consultation with the organisers — from the submitted abstracts. We have been fortunate to have very high-quality, thought stimulating and interesting talks at all levels, which, together with the discussions among the participants, made the conference quite enjoyable. There were 152 registered participants for the event.

Homoeologous recombination-based transfer and molecular cytogenetic mapping of a wheat streak mosaic virus and Triticum mosaic virus resistance gene Wsm3 from Thinopyrum intermedium to wheat.

PubMed

Danilova, Tatiana V; Zhang, Guorong; Liu, Wenxuan; Friebe, Bernd; Gill, Bikram S

2017-03-01

Here, we report the production of a wheat- Thinopyrum intermedium recombinant stock conferring resistance to wheat streak mosaic virus and Triticum mosaic virus. Wheat streak mosaic caused by the wheat streak mosaic virus (WSMV) is an important disease of bread wheat (Triticum aestivum) worldwide. To date, only three genes conferring resistance to WSMV have been named and two, Wsm1 and Wsm3, were derived from the distantly related wild relative Thinopyrum intermedium. Wsm3 is only available in the form of a compensating wheat-Th. intermedium whole-arm Robertsonian translocation T7BS·7S#3L. Whole-arm alien transfers usually suffer from linkage drag, which prevents their use in cultivar improvement. Here, we report ph1b-induced homoeologous recombination to shorten the Th. intermedium segment and recover a recombinant chromosome consisting of the short arm of wheat chromosome 7B, part of the long arm of 7B, and the distal 43% of the long arm derived from the Th. intermedium chromosome arm 7S#3L. The recombinant chromosome T7BS·7BL-7S#3L confers resistance to WSMV at 18 and 24 °C and also confers resistance to Triticum mosaic virus, but only at 18 °C. Wsm3 is the only gene conferring resistance to WSMV at a high temperature level of 24 °C. We also developed a user-friendly molecular marker that will allow to monitor the transfer of Wsm3 in breeding programs. Wsm3 is presently being transferred to adapted hard red winter wheat cultivars and can be used directly in wheat improvement.

Ranking major and minor research misbehaviors: results from a survey among participants of four World Conferences on Research Integrity.

PubMed

Bouter, Lex M; Tijdink, Joeri; Axelsen, Nils; Martinson, Brian C; Ter Riet, Gerben

2016-01-01

Codes of conduct mainly focus on research misconduct that takes the form of fabrication, falsification, and plagiarism. However, at the aggregate level, lesser forms of research misbehavior may be more important due to their much higher prevalence. Little is known about what the most frequent research misbehaviors are and what their impact is if they occur. A survey was conducted among 1353 attendees of international research integrity conferences. They were asked to score 60 research misbehaviors according to their views on and perceptions of the frequency of occurrence, preventability, impact on truth (validity), and impact on trust between scientists on 5-point scales. We expressed the aggregate level impact as the product of frequency scores and truth, trust and preventability scores, respectively. We ranked misbehaviors based on mean scores. Additionally, relevant demographic and professional background information was collected from participants. Response was 17% of those who were sent the invitational email and 33% of those who opened it. The rankings suggest that selective reporting, selective citing, and flaws in quality assurance and mentoring are viewed as the major problems of modern research. The "deadly sins" of fabrication and falsification ranked highest on the impact on truth but low to moderate on aggregate level impact on truth, due to their low estimated frequency. Plagiarism is thought to be common but to have little impact on truth although it ranked high on aggregate level impact on trust. We designed a comprehensive list of 60 major and minor research misbehaviors. Our respondents were much more concerned over sloppy science than about scientific fraud (FFP). In the fostering of responsible conduct of research, we recommend to develop interventions that actively discourage the high ranking misbehaviors from our study.

International High/Scope Registry Conference Proceedings (Ypsilanti, Michigan, May 5-8, 1998).

ERIC Educational Resources Information Center

High/Scope Educational Research Foundation, Ypsilanti, MI.

These conference proceedings provide summaries of 71 presentations on various aspects of the High/Scope educational approach. In addition to summaries of special presentations on music and movement, topics addressed include: (1) student engagement; (2) outdoor learning; (3) change strategies; (4) various discussions of the Child Observation…

High accumulation of anthocyanins via the ectopic expression of AtDFR confers significant salt stress tolerance in Brassica napus L.

PubMed

Kim, Jihye; Lee, Won Je; Vu, Tien Thanh; Jeong, Chan Young; Hong, Suk-Whan; Lee, Hojoung

2017-08-01

The ectopic expression of AtDFR results in increased accumulation of anthocyanins leading to enhanced salinity and drought stress tolerance in B. napus plants. Flavonoids with antioxidant effects confer many additional benefits to plants. Evidence indicates that flavonoids, including anthocyanins, protect tissues against oxidative stress from various abiotic stressors. We determined whether increases in anthocyanins increased abiotic stress tolerance in Brassica napus, because the values of B. napus L. and its cultivation area are increasing worldwide. We overexpressed Arabidopsis dihydroflavonol-4-reductase (DFR) in B. napus. Increased DFR transcript levels for AtDFR-OX B. shoots correlated with higher anthocyanin accumulation. AtDFR-OX Brassica shoots exhibited lower reactive oxygen species (ROS) accumulation than wild-type (WT) shoots under high NaCl and mannitol concentrations. This was corroborated by 3,3-diaminobenzidine staining for ROS scavenging activity in 1,1-diphenyl-2-picryl-hydrazyl assays. Shoots of the AtDFR-OX B. napus lines grown in a high salt medium exhibited enhanced salt tolerance and higher chlorophyll content than similarly grown WT plants. Our observations suggested that the AtDFR gene can be effectively manipulated to modulate salinity and drought stress tolerance by directing to high accumulation of anthocyanins in oilseed plants.

Policy Conference on Highly Qualified Manpower, Paris, 26-28 September 1966.

ERIC Educational Resources Information Center

Organisation for Economic Cooperation and Development, Paris (France). Centre for Educational Research and Innovation.

This conference report provides a general view of the problems arising in the education and utilization of qualified manpower and the possibility of identifying the policy measures needed in order to facilitate their solution. Part I of the report gives an account of the proceedings of the conference. Part II presents extracts from or summaries of…

International Society for the Social Studies Annual Conference Proceedings (Orlando, Florida, February 26-27, 2009). Volume 2009, Issue 1

ERIC Educational Resources Information Center

Russell, William Benedict, III, Ed.

2009-01-01

The "International Society for the Social Studies Annual Conference Proceedings" is a peer-reviewed professional publication published once a year following the annual conference. It contains the following papers: (1) Teacher Perceptions of Authentic Pedagogy: A Case Study of Professional Development in an African American High School's…

Combination of Pneumococcal Surface Protein A (PspA) with Whole Cell Pertussis Vaccine Increases Protection Against Pneumococcal Challenge in Mice

PubMed Central

Ferreira, Daniela M.; Moreno, Adriana T.; Ferreira, Patricia C. D.; Lima, Fernanda A.; Santos, Fernanda L.; Sakauchi, Maria Aparecida; Takata, Célia S.; Higashi, Hisako G.; Raw, Isaías; Kubrusly, Flavia S.; Ho, Paulo L.

2010-01-01

Streptococcus pneumoniae is the leading cause of respiratory acute infections around the world. In Latin America, approximately 20,000 children under 5 years of age die of pneumococcal diseases annually. Pneumococcal surface protein A (PspA) is among the best-characterized pneumococcal antigens that confer protection in animal models of pneumococcal infections and, as such, is a good alternative for the currently available conjugated vaccines. Efficient immune responses directed to PspA in animal models have already been described. Nevertheless, few low cost adjuvants for a subunit pneumococcal vaccine have been proposed to date. Here, we have tested the adjuvant properties of the whole cell Bordetella pertussis vaccine (wP) that is currently part of the DTP (diphtheria-tetanus-pertussis) vaccine administrated to children in several countries, as an adjuvant to PspA. Nasal immunization of BALB/c mice with a combination of PspA5 and wP or wPlow – a new generation vaccine that contains low levels of B. pertussis LPS – conferred protection against a respiratory lethal challenge with S. pneumoniae. Both PspA5-wP and PspA5-wPlow vaccines induced high levels of systemic and mucosal antibodies against PspA5, with similar profile, indicating no essential requirement for B. pertussis LPS in the adjuvant properties of wP. Accordingly, nasal immunization of C3H/HeJ mice with PspA5-wP conferred protection against the pneumococcal challenge, thus ruling out a role for TLR4 responses in the adjuvant activity and the protection mechanisms triggered by the vaccines. The high levels of anti-PspA5 antibodies correlated with increased cross-reactivity against PspAs from different clades and also reflected in cross-protection. In addition, passive immunization experiments indicated that antibodies played an important role in protection in this model. Finally, subcutaneous immunization with a combination of PspA5 with DTPlow protected mice against challenge with two different pneumococcal strains, opening the possibility for the development of a combined infant vaccine composed of DTP and PspA. PMID:20523738

Role of a Novel I1781T Mutation and Other Mechanisms in Conferring Resistance to Acetyl-CoA Carboxylase Inhibiting Herbicides in a Black-Grass Population

PubMed Central

Kaundun, Shiv Shankhar; Hutchings, Sarah-Jane; Dale, Richard P.; McIndoe, Eddie

2013-01-01

Background Knowledge of the mechanisms of herbicide resistance is important for designing long term sustainable weed management strategies. Here, we have used an integrated biology and molecular approach to investigate the mechanisms of resistance to acetyl-CoA carboxylase inhibiting herbicides in a UK black-grass population (BG2). Methodology/Principal Findings Comparison between BG2 phenotypes using single discriminant rates of herbicides and genotypes based on ACCase gene sequencing showed that the I1781L, a novel I1781T, but not the W2027C mutations, were associated with resistance to cycloxydim. All plants were killed with clethodim and a few individuals containing the I1781L mutation were partially resistant to tepraloxydim. Whole plant dose response assays demonstrated that a single copy of the mutant T1781 allele conferred fourfold resistance levels to cycloxydim and clodinafop-propargyl. In contrast, the impact of the I1781T mutation was low (Rf = 1.6) and non-significant on pinoxaden. BG2 was also characterised by high levels of resistance, very likely non-target site based, to the two cereal selective herbicides clodinafop-propargyl and pinoxaden and not to the poorly metabolisable cyclohexanedione herbicides. Analysis of 480 plants from 40 cycloxydim resistant black grass populations from the UK using two very effective and high throughput dCAPS assays established for detecting any amino acid changes at the 1781 ACCase codon and for positively identifying the threonine residue, showed that the occurrence of the T1781 is extremely rare compared to the L1781 allele. Conclusion/Significance This study revealed a novel mutation at ACCase codon position 1781 and adequately assessed target site and non-target site mechanisms in conferring resistance to several ACCase herbicides in a black-grass population. It highlights that over time the level of suspected non-target site resistance to some cereal selective ACCase herbicides have in some instances surpassed that of target site resistance, including the one endowed by the most commonly encountered I1781L mutation. PMID:23936046

Coordinating an interdisciplinary disease management conference on a military installation: collaboration between military and civilian communities, lessons learned.

PubMed

Lewis-Fleming, Glenda; Knapp, Casey A

2009-08-01

The needs of individuals with chronic diseases or disabilities are similar whether within military or civilian communities. With finite resources and the continuing global war on terrorism, military treatment facilities (MTFs) may find collaborative, multidisciplinary, continuing education efforts with community agencies invaluable. Collaborative efforts that bring military and civilian communities together can result in innovative programs that offer cost-effective high-quality information to enhance the knowledge and skill level of military families, providers, and other professionals who provide services and care for military eligible beneficiaries. This article addresses the development and implementation of two major multidisciplinary disease management conferences at Naval Medical Center Portsmouth (NMCP), Virginia. It provides an overview of lessons learned in the areas of preplanning, team building, program development, implementation, and evaluation. Despite challenges, tremendous benefits may be reaped from efforts to include diverse target populations from military and civilian communities.

Uncertainty and Surprise: Ideas from the Open Discussion

NASA Astrophysics Data System (ADS)

Jordan, Michelle E.

Approximately one hundred participants met for three days at a conference entitled "Uncertainty and Surprise: Questions on Working with the Unexpected and Unknowable." There were a diversity of conference participants ranging from researchers in the natural sciences and researchers in the social sciences (business professors, physicists, ethnographers, nursing school deans) to practitioners and executives in public policy and management (business owners, health care managers, high tech executives), all of whom had varying levels of experience and expertise in dealing with uncertainty and surprise. One group held the traditional, statistical view that uncertainty comes from variance and events that are described by usually unimodal probability law. A second group was comfortable on the one hand with phase diagrams and the phase transitions that come from systems with multi-modal distributions, and on the other hand, with deterministic chaos. A third group was comfortable with the emergent events from evolutionary processes that may not have any probability laws at all.

Government Venture Capital: A Case Study of the In-Q-Tel Model

DTIC Science & Technology

2004-03-23

their IP during the contracting process. “The folklore is that the government has a reputation for ‘ poaching ’ technology, either by getting a hook into...the introductions to individuals that can make a significant impact to a company’s business. Often these include members of government, industry...result of an In-Q-Tel-sponsored conference. Company 2 said that In-Q-Tel has made a significant impact by providing high-level introductions at

Proceedings of the Annual Conference of the Military Testing Association (23rd) held at Arlington, Virginia, on 25-30 October 1981. Volume 1

DTIC Science & Technology

1981-01-01

instruction and type of task, and method of instruction and ability level were found with respect to school ... student . Methods of instruction that reduce the intellectual demand often reduce the differences between high and low ability students (Cronbach and...Snow, 1977). If these methods are applied to instruction of low ability students over a long period, many low ability students may equal or excel

URREF Reliability Versus Credibility in Information Fusion

DTIC Science & Technology

2013-07-01

Fusion, Vol. 3, No. 2, December, 2008. [31] E. Blasch, J. Dezert, and P. Valin , “DSMT Applied to Seismic and Acoustic Sensor Fusion,” Proc. IEEE Nat...44] E. Blasch, P. Valin , E. Bossé, “Measures of Effectiveness for High- Level Fusion,” Int. Conference on Information Fusion, 2010. [45] X. Mei, H...and P. Valin , “Information Fusion Measures of Effectiveness (MOE) for Decision Support,” Proc. SPIE 8050, 2011. [49] Y. Zheng, W. Dong, and E

The genetic basis of adaptive pigmentation variation in Drosophila melanogaster.

PubMed

Pool, John E; Aquadro, Charles F

2007-07-01

In a broad survey of Drosophila melanogaster population samples, levels of abdominal pigmentation were found to be highly variable and geographically differentiated. A strong positive correlation was found between dark pigmentation and high altitude, suggesting adaptation to specific environments. DNA sequence polymorphism at the candidate gene ebony revealed a clear association with the pigmentation of homozygous third chromosome lines. The darkest lines sequenced had nearly identical haplotypes spanning 14.5 kb upstream of the protein-coding exons of ebony. Thus, natural selection may have elevated the frequency of an allele that confers dark abdominal pigmentation by influencing the regulation of ebony.

Influence of academical institutes on educational processes

NASA Astrophysics Data System (ADS)

Chernyakov, S. M.

Murmansk is in the most northern European part of Russia and has problems with a higher educational system and with preparation of some necessary specialists for organizations of our region. They are consequencies of social and economical changes in the Russian society. But it gives a chance to revalue our system of higher education and a role of society and academical institutes in the process of education. During several years the Russian government supports a program ``Integration of basic science and higher school'' which has an aim to unite efforts of educational and academical organizations for to solve some educational and scientific problems of higher school using a potential of academical society. We decided to use the support of our government for solving of the part of our problems. In 1999 we had offered to organize a regional scientific student conference devoted to natural-science problems of the Arctic region and the project was supported. The first experience of the conference was obtained during the May 2000 when in Murmansk it was conducted the 1st regional scientific student conference devoted to physics and methods investigation of high-latitude atmosphere. The conference was organized by the Polar Geophysical Institute of the Kola Scientific Centre of the Russian Academy of Sciences together with the Murmansk State Pedagogical University and the Murmansk State Technical University. It had a broad response and continuation. This year we shall conduct already the 5th conference ''Natural-science problems of the Arctic region'' which will take place in April. We receive reports of students from the Murmansk region and also from Arkhangelsk, Novgorod, Petrozavodsk, Sankt-Petersburg, Tumen, Yakutsk and other regions of Russia. It is experience of involving in the conference students from other regions of Russia which do investigations in the field. We plan to organize during the conference (as a part of it) a videoconference. We hope that those students which shall not be able to be at our conference will have the possibility to take part in it through an Internet connection. Nowadays a situation in education of northern regions needs that educational higher school organizations as well as a society must work together more closely for to strengthen educational level of our regions and to give more sustainable development of them.

An initial examination of the potential role of T-cell immunity in protection against feline immunodeficiency virus (FIV) infection.

PubMed

Aranyos, Alek M; Roff, Shannon R; Pu, Ruiyu; Owen, Jennifer L; Coleman, James K; Yamamoto, Janet K

2016-03-14

The importance of vaccine-induced T-cell immunity in conferring protection with prototype and commercial FIV vaccines is still unclear. Current studies performed adoptive transfer of T cells from prototype FIV-vaccinated cats to partial-to-complete feline leukocyte antigen (FLA)-matched cats a day before either homologous FIVPet or heterologous-subtype pathogenic FIVFC1 challenge. Adoptive-transfer (A-T) conferred a protection rate of 87% (13 of 15, p < 0.001) against FIVPet using the FLA-matched T cells, whereas all 12 control cats were unprotected. Furthermore, A-T conferred protection rate of 50% (6 of 12, p<0.023) against FIVFC1 using FLA-matched T cells, whereas all 8 control cats were unprotected. Transfer of FLA-matched T and B cells demonstrated that T cells are needed to confer A-T protection. In addition, complete FLA-matching and addition of T-cell numbers > 13 × 10(6) cells were required for A-T protection against FIVFC1 strain, reported to be a highly pathogenic virus resistant to vaccine-induced neutralizing-antibodies. The addition of FLA-matched B cells alone was not protective. The poor quality of the anti-FIV T-cell immunity induced by the vaccine likely contributed to the lack of protection in an FLA-matched recipient against FIVFC1. The quality of the immune response was determined by the presence of high mRNA levels of cytolysin (perforin) and cytotoxins (granzymes A, B, and H) and T helper-1 cytokines (interferon-γ [IFNγ] and IL2). Increased cytokine, cytolysin and cytotoxin production was detected in the donors which conferred protection in A-T studies. In addition, the CD4(+) and CD8(+) T-cell proliferation and/or IFNγ responses to FIV p24 and reverse transcriptase increased with each year in cats receiving 1X-3X vaccine boosts over 4 years. These studies demonstrate that anti-FIV T-cell immunity induced by vaccination with a dual-subtype FIV vaccine is essential for prophylactic protection against AIDS lentiviruses such as FIV and potentially HIV-1. Copyright © 2016 Elsevier Ltd. All rights reserved.

An initial examination of the potential role of T-cell immunity in protection against feline immunodeficiency virus (FIV) infection

PubMed Central

Aranyos, Alek M.; Roff, Shannon R.; Pu, Riuyu; Owen, Jennifer L.; Coleman, James K.; Yamamoto, Janet K.

2016-01-01

The importance of vaccine-induced T-cell immunity in conferring protection with prototype and commercial FIV vaccines is still unclear. Current studies performed adoptive transfer of T cells from prototype FIV-vaccinated cats to partial-to-complete feline leukocyte antigen (FLA)-matched cats a day before either homologous FIVPet or heterologous-subtype pathogenic FIVFC1 challenge. Adoptive-transfer (A–T) conferred a protection rate of 87% (13 of 15, p<0.001) against FIVPet using FLA-matched T cells, whereas all 12 control cats were unprotected. Furthermore, A-T conferred protection rate of 50% (6 of 12, p<0.023) against FIVFC1 using FLA-matched T cells, whereas all 8 control cats were unprotected. Transfer of FLA-matched T and B cells demonstrated that T cells are needed to confer A-T protection. In addition, complete FLA-matching and addition of T-cell numbers >13×106 cells were required for A-T protection against FIVFC1 strain, reported to be a highly pathogenic virus resistant to vaccine-induced neutralizing-antibodies. The addition of FLA-matched B cells alone was not protective. The poor quality of the anti-FIV T-cell immunity induced by the vaccine likely contributed to the lack of protection in an FLA-matched recipient against FIVFC1. The quality of the immune response was determined by the presence of high mRNA levels of cytolysin (perforin) and cytotoxins (granzymes A, B, and H) and T helper-1 cytokines (interferon-γ [IFNγ] and IL2). Increased cytokine, cytolysin and cytotoxin production was detected in the donors which conferred protection in A-T studies. In addition, the CD4+ and CD8+ T-cell proliferation and/or IFNγ responses to FIV p24 and reverse transcriptase increased with each year in cats receiving 1X-3X vaccine boosts over 4 years. These studies demonstrate that anti-FIV T-cell immunity induced by vaccination with a dual-subtype FIV vaccine is essential for prophylactic protection against AIDS lentiviruses such as FIV and potentially HIV-1. PMID:26802606

The Healthgrid White Paper.

PubMed

Breton, Vincent; Dean, Kevin; Solomonides, Tony; Blanquer, I; Hernandez, V; Medico, E; Maglaveras, N; Benkner, S; Lonsdale, G; Lloyd, S; Hassan, K; McClatchey, R; Miguet, S; Montagnat, J; Pennec, X; De Neve, W; De Wagter, C; Heeren, G; Maigne, L; Nozaki, K; Taillet, M; Bilofsky, H; Ziegler, R; Hoffman, M; Jones, C; Cannataro, M; Veltri, P; Aloisio, G; Fiore, S; Mirto, M; Chouvarda, I; Koutkias, V; Malousi, A; Lopez, V; Oliveira, I; Sanchez, J P; Martin-Sanchez, F; De Moor, G; Claerhout, B; Herveg, J A M

2005-01-01

Over the last four years, a community of researchers working on Grid and High Performance Computing technologies started discussing the barriers and opportunities that grid technologies must face and exploit for the development of health-related applications. This interest lead to the first Healthgrid conference, held in Lyon, France, on January 16th-17th, 2003, with the focus of creating increased awareness about the possibilities and advantages linked to the deployment of grid technologies in health, ultimately targeting the creation of a European/international grid infrastructure for health. The topics of this conference converged with the position of the eHealth division of the European Commission, whose mandate from the Lisbon Meeting was "To develop an intelligent environment that enables ubiquitous management of citizens' health status, and to assist health professionals in coping with some major challenges, risk management and the integration into clinical practice of advances in health knowledge." In this context "Health" involves not only clinical procedures but covers the whole range of information from molecular level (genetic and proteomic information) over cells and tissues, to the individual and finally the population level (social healthcare). Grid technology offers the opportunity to create a common working backbone for all different members of this large "health family" and will hopefully lead to an increased awareness and interoperability among disciplines. The first HealthGrid conference led to the creation of the Healthgrid association, a non-profit research association legally incorporated in France but formed from the broad community of European researchers and institutions sharing expertise in health grids. After the second Healthgrid conference, held in Clermont-Ferrand on January 29th-30th, 2004, the need for a "white paper" on the current status and prospective of health grids was raised. Over fifty experts from different areas of grid technologies, eHealth applications and the medical world were invited to contribute to the preparation of this document.

Conference on the Sustainable Development of Small Island Developing States: year-end update.

PubMed

Chasek, P; Goree, L J

1993-12-21

A brief description is given of the background behind the Small Island States Global Conference scheduled for March 1994. Preliminary meetings led to the formation of a draft program of action pertaining to climatic change and sea level increases, natural and environmental disasters, freshwater resources, management of wastes, coastal and marine resources, land and energy resources, tourism and biodiversity resources, regional institutions and technical cooperation, and a variety of other topics. Little agreement was reached on implementation, monitoring, and review among member states, which called for additional meetings. The World Coast Conference, held in November 1993, focused on progressive sustainable development and integrated coastal zone management (ICZM). Participants agreed on the necessity to 1) strengthen state's capabilities for ICZM, 2) identify priorities, 3) set up comprehensive and flexible assessment mechanisms, 4) coordinate activities at all levels, and 5) address longterm concerns. Only two nongovernmental organizations (NGOs) sent reports on donor activities. Host country meetings were held in Barbados in preparation for the planned 1994 Conference and settlement of logistics. CNN will provide television coverage of the Conference and produce documentaries on small island states. General Assembly highlights included summary statements by Belgium, Vanuatu, Maldives, the Caribbean community, Korea, and Australia members. The Barbados Declaration, which is in process and will be adopted in some form at the 1994 Conference, may incorporate elements from the Rio Declaration on Environment and Development. The Ecojournalism workshop scheduled for Jamaica in January 1994 is aiming to instill awareness of the 1994 Conference and small island issues. 157 NGOs have received accreditation for the 1994 Conference, of which 50 are from small island states, 50 from developed countries, and 53 from nonisland developing countries. The NGO Liaison Committee will focus on workshops on special issues, examples of sustainable development such as the Village of Hope, and a showcase of affordable technologies and services in order to achieve more sustainable patterns of development.

14th High-Tech Plasma Processes Conference (HTPP 14)

NASA Astrophysics Data System (ADS)

2017-04-01

Preface The High-Tech Plasma Processes Conference (HTPP) is a bi-annual international conference based in Europe with topics encompassing the whole area of plasma processing science. This conference is open to all the international community in the world involved in plasma science and plasma technology. The aim of the conference is to bring different scientific communities together, facilitate the contacts between science, technology and industry and provide a platform for the exploration of both fundamental topics and new applications of plasmas. For this edition of HTPP, as was the case for the last, we have achieved a well balanced participation from the communities of both thermal and non-thermal plasma researchers. 75 people from 17 countries attended the conference with the total number of contributions being 74, consisting of 19 invited talks and 55 poster contributions. As a HTPP tradition a poster competition has been carried out during the conference. The winner of the poster competition was Fabrice Mavier from Université de Limoges, France with his paper “Pulsed arc plasma jet synchronized with drop-on-demand dispenser” All the participants also ejoyed the social program including an “unconventional” tour of the city, the visit to the famous Hofbräuhaus and the dinner at the Blutenburg, a beautiful inner-city castle. We have received papers corresponding to the contributions of HTPP-2014 that have been submitted for publication in this volume of Journal of Physics: Conference Series. Each submitted contribution has been peer reviewed and the Editors are very grateful to the referees for their careful support in improving the original manuscripts. In total, 18 manuscripts have been accepted for publication covering a range of topics of plasma processing science from plasma fundamentals to process applications through to experiments, diagnostics and modelling. We deeply thank the authors for their enthusiastic and high-grade contributions and we are convinced that this volume of Journal of Physics: Conference Series will be interesting for our community. Finally, we would like to thank the conference chairmen, the members of the steering committee, the international scientific committee, the local organizing committee, the organizing secretariat and the financial support from the conference sponsors that allowed the success of HTPP-2016. The Editors of the HTPP-2016 Proceedings Dr. Dirk Uhrlandt, head of the ISC Prof. Philippe Teulet Prof. Jochen Schein Neubiberg, 6th of March 2017

PREFACE: International Conference on the Applications of the Mössbauer Effect (ICAME 2009)

NASA Astrophysics Data System (ADS)

Müller, Herbert; Reissner, Michael; Steiner, Walter; Wiesinger, Günter

2010-04-01

The International Conference on the Applications of the Mössbauer Effect (ICAME2009) was held for the first time in Austria, at the Vienna University of Technology on 19-24 July 2009. This largest conference of the Mössbauer community attracted much interest, nearly 500 colleagues announced their intention to participate. Unfortunately, due to the world-wide finance crisis, in the end many could not manage to come. Nevertheless 380 abstracts were submitted. More than 300 participants from 38 countries were present at the conference. The programme contained 20 invited talks, selected by the international advisory board. 49 contributions were selected for oral presentation. Following the advice of the IBAME board, no parallel sessions were organized. Therefore most of the work was presented as posters, attached for the whole week, giving thus the opportunity for intense discussions outside of the poster sessions. A special tutorial session, dedicated to Mössbauer spectroscopy with synchrotron radiation, organized by R Rüffer was held on the first day. It was included in the conference programme giving all participants the opportunity to attend this meeting. Although lasting until late in the evening, the audience was always well occupied. New developments in the field of iron-containing superconductors were discussed in a micro symposium. The scientific level of the whole conference was high. After thorough peer-reviewing, 147 papers were accepted by the referees and are presented in this volume. ICAME2009 was possible due to the efforts of many people, in the organizing committee, the programme committee and the editorial board and to the students who took care of the participants during the conference and all social activities. ICAME2009 was in several ways a special conference. It was the 30th in the series of ICAME meetings, and the first after the celebration of 50 years of the Mössbauer Effect. In 2009 Rudolf Mössbauer also celebrated his 80th birthday. The positive atmosphere, the high attendance in the sessions and the lively discussions made the conference a great success and a memorable event. It was pointed out, that Mössbauer spectroscopy is still an interesting and powerful method with great opportunities in the future. Herbert Müller (Secretary) Michael Reissner (Chairman) This book is dedicated to our colleagues Nicol Malcom, who could not come, because he suddenly died a few weeks in advance to the conference and Hercilio Rechenberg, who died on his way home from Vienna. Conference photograph Conference Organisation Local Organizing Committee Reissner Michael (Chairman)Müller Herbert (Conference Secretary) Amthauer Georg Lottermoser WernerSteiner Walter Bauer Ernst Michor Herwig Vogl Gero Bühler-Paschen Silke Müller Martin Waas Monika Grodzicki Michael Redhammer Günther Wiesinger Günter Grössinger Roland Sassik Herbert Hilscher Gerfried Sepiol Bogdan International Programme Committee Amthauer Georg Gütlich Philipp Steiner Walter Baggio-Saitovich Elisa Litterst Fred Jochen Trautwein Alfred Xaver Berry Frank Long Gary Vogl Gero Felner Israel Nagy Denes Lajos Yoshida Yutaka Greneche Jean-Marc Rüffer Rudolf International Advisory Board Alp E ErcanGénin Jean-Marie Baggio-Saitovitch Elisa Greneche Jean-Marc Miglierini Marcel Balogh Judit Grodzicki Michael Musić Svetozar Bender Koch Christian Gütlich Philipp Nagy Dénes Lajos Berry Frank Häggström Lennart Nishida Tetsuaki Brown Dennis Hanzel Darko Pérez Alcázar German Campbell Stewart Hassaan Mohamed Yousri Rüffer Rudolf Carbucicchio Massimo Jumas Jean-Claude Ryan Dominic H Croci Simonetta Kadyrzhanov Kariat Sanchez Francisco Di Naili Katila Toivo Schünemann Volker Elzain Mohamed Kim Chul Sung Stanek Jan Fabris José Domingos Klingelhöfer Göstar Stevens John Felner Israel Langouche Guido Suzdalev Igor P Fern George R Lyubutin Igor S Szymanski Krzysztof Forder Sue D Marco Jose F Waanders Frans Gajbhiye Nandeo Mašlaň Miroslav Yoshida Yutaka

NATIONAL CONFERENCE ON URBAN STORM WATER: ENHANCING PROGRAMS AT THE LOCAL LEVEL - PROCEEDINGS CHICAGO, IL FEBRUARY 17-20, 2003

EPA Science Inventory

A wide array of effective storm water management and resource protection tools have been developed for urban environments, but their implementation continues to be hampered by a lack of technology transfer opportunities. At the national conference Urban Storm Water: Enhancing Pro...

Top Ten Musings about Publishing Qualitative Manuscripts: Managing the Devil in the Details

ERIC Educational Resources Information Center

Palladino, John M.

2011-01-01

The purpose of this presentation was to engage in dialogue with editors of other qualitative journals and conference participants about the common roadblocks that hinder the publication possibilities for qualitative research studies. All audience participants were conference presenters and/or qualitative researchers, novice level and above. The…

National Land Use Policy: Objectives, Components, Implementation.

ERIC Educational Resources Information Center

Soil Conservation Society of America, Ankeny, IA.

Proceedings of a special conference sponsored by the Soil Conservation Society of America, are compiled in this report. The conference served as a forum for those involved in land use planning and implementation at all levels of government and private enterprise. Comments were directed to four main topics: (1) Objectives and Need for a National…

Bridging Learning Opportunities: AMTEC '93 Conference Proceedings (Windsor, Ontario, Canada, June 14-16, 1993).

ERIC Educational Resources Information Center

Selby, Stuart, Ed.; Marzotto, Esio, Ed.

The bridging theme of the AMTEC'93 conference provided the stimulation to look beyond traditional boundaries: across international borders; across levels of disciplines and school systems; across social differences and across individual differences. These bridges can help make learning more effective, as can attention to related contemporary…

Avoiding Predatory Journals and Questionable Conferences: A Resource Guide

ERIC Educational Resources Information Center

Eaton, Sarah Elaine

2018-01-01

Purpose: The goal of this guide is to provide a clear overview of the topics of predatory journals and questionable conferences and advice on how to avoid them. This guide intentionally adopts a plain language approach to ensure it is accessible to readers with a variety English language proficiency levels. Methods: Electronic searches were…

Proceedings: Conference on Institutional Planning in Community Colleges (Seattle, Washington, April 29-30, 1976). Occasional Paper Number 27.

ERIC Educational Resources Information Center

Morishima, James K., Ed.; And Others

This document contains three conference papers concerning institutional research at the community college level. Ann Bromley discusses the practical implications of institutional research. The president, administrative staff, and faculty must be involved in identification of research issues, formulation of design, and application of findings.…

American Council on Consumer Interests Annual Conference (37th, Cincinnati, Ohio, April 3-6, 1991). The Proceedings.

ERIC Educational Resources Information Center

Haldeman, Virginia, Ed.

These conference proceedings include 88 presentations, workshops, and poster sessions. Topics include child support guidelines, food quality and safety, family resource management expert systems, airline deregulation, home-based employment, consumer education, Europe in the 1990s, low-reading level consumers, children as consumers, promotional…

NASA Public Affairs and NUANCE Lab News Conference at Reno-Stead Airport.

NASA Image and Video Library

2016-10-19

News Conference following the test of Unmanned Aircraft Systems Traffic Management (UTM) technical capability Level 2 (TCL2) at Reno-Stead Airport, Nevada. Parimal Kopardekar, NASA Ames Senior Engineer for Ait Transportation Systems gave an overview of UTM (Left). Huy Tran, NASA Ames Aeronautics Director, presents NASA UTM Project Overview.

Joint American Nuclear Society and Health Physics Society Conference: Applicability of Radiation Response Models to Low Dose Protection Standards.

PubMed

Glines, Wayne M; Markham, Anna

2018-05-01

Seventy-five years after the Hanford Site was initially created as the primary plutonium production site for atomic weapons development under the Manhattan Project, the American Nuclear Society and the Health Physics Society are sponsoring a conference from 30 September through 3 October 2018, in Pasco, Washington, titled "Applicability of Radiation Response Models to Low Dose Protection Standards." The goal of this conference is to use current scientific data to update the approach to regulating low-level radiation doses; i.e., to answer a quintessential question of radiation protection-how to best develop radiation protection standards that protect human populations against detrimental effects while allowing the beneficial uses of radiation and radioactive materials. Previous conferences (e.g., "Wingspread Conference," "Arlie Conference") have attempted to address this question; but now, almost 20 y later, the key issues, goals, conclusions, and recommendations of those two conferences remain and are as relevant as they were then. Despite the best efforts of the conference participants and increased knowledge and understanding of the science underlying radiation effects in human populations, the bases of current radiation protection standards have evolved little. This 2018 conference seeks to provide a basis and path forward for evolving radiation protection standards to be more reflective of current knowledge and understanding of low dose response models.

International Conference on Intelligent Systems for Molecular Biology (ISMB)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Goldberg, Debra; Hibbs, Matthew; Kall, Lukas

The Intelligent Systems for Molecular Biology (ISMB) conference has provided a general forum for disseminating the latest developments in bioinformatics on an annual basis for the past 13 years. ISMB is a multidisciplinary conference that brings together scientists from computer science, molecular biology, mathematics and statistics. The goal of the ISMB meeting is to bring together biologists and computational scientists in a focus on actual biological problems, i.e., not simply theoretical calculations. The combined focus on "intelligent systems" and actual biological data makes ISMB a unique and highly important meeting, and 13 years of experience in holding the conference hasmore » resulted in a consistently well organized, well attended, and highly respected annual conference. The ISMB 2005 meeting was held June 25-29, 2005 at the Renaissance Center in Detroit, Michigan. The meeting attracted over 1,730 attendees. The science presented was exceptional, and in the course of the five-day meeting, 56 scientific papers, 710 posters, 47 Oral Abstracts, 76 Software demonstrations, and 14 tutorials were presented. The attendees represented a broad spectrum of backgrounds with 7% from commercial companies, over 28% qualifying for student registration, and 41 countries were represented at the conference, emphasizing its important international aspect. The ISMB conference is especially important because the cultures of computer science and biology are so disparate. ISMB, as a full-scale technical conference with refereed proceedings that have been indexed by both MEDLINE and Current Contents since 1996, bridges this cultural gap.« less

Frontiers in biomedical engineering and biotechnology.

PubMed

Liu, Feng; Goodarzi, Ali; Wang, Haifeng; Stasiak, Joanna; Sun, Jianbo; Zhou, Yu

2014-01-01

The 2nd International Conference on Biomedical Engineering and Biotechnology (iCBEB 2013), held in Wuhan on 11–13 October 2013, is an annual conference that aims at providing an opportunity for international and national researchers and practitioners to present the most recent advances and future challenges in the fields of Biomedical Information, Biomedical Engineering and Biotechnology. The papers published by this issue are selected from this conference, which witnesses the frontier in the field of Biomedical Engineering and Biotechnology, which particularly has helped improving the level of clinical diagnosis in medical work.

Epigenetics, eh! A meeting summary of the Canadian Conference on Epigenetics.

PubMed

Rodenhiser, David I; Bérubé, Nathalie G; Mann, Mellissa R W

2011-10-01

In May 2011, the Canadian Conference on Epigenetics: Epigenetics Eh! was held in London, Canada. The objectives of this conference were to showcase the breadth of epigenetic research on environment and health across Canada and to provide the catalyst to develop collaborative Canadian epigenetic research opportunities, similar to existing international epigenetic initiatives in the US and Europe. With ten platform sessions and two sessions with over 100 poster presentations, this conference featured cutting-edge epigenetic research, presented by Canadian and international principal investigators and their trainees in the field of epigenetics and chromatin dynamics. An EpigenART competition included ten artists, creating a unique opportunity for artists and scientists to interact and explore their individual interpretations of this scientific discipline. The conference provided a unique venue for a significant cross-section of Canadian epigenetic researchers from diverse disciplines to meet, interact, collaborate and strategize at the national level.

Effect of gamma-irradiation on the levels of total and cis/trans isomers of beta-carotene in dehydrated parsley

NASA Astrophysics Data System (ADS)

Sebastião, Kátia I.; Almeida-Muradian, Lígia B.; Romanelli, Maria Fernanda; Koseki, Paula Massae; Villavicencio, Anna Lúcia C. H.

2002-03-01

Ionizing radiation is a method for preservation of foods that use the high energy of gamma rays or accelerated electrons, thereby ionizing molecules. The most important precursor of vitamin A is β-carotene, a carotenoid with pro-vitamin A activity. The highly unsaturated chain confers the instability of β-carotene, and some reactions, as isomerisation, can reduce the characteristics of pro-vitamin A. The present study investigated whether increasing doses of 0, 10 and 20 kGy lower the total β-carotene level and if an enhancement of cis-isomers occurred on samples of dehydrated parsley. No differences were observed of either fractions analyzed at doses applied in this study, nor did it contribute to the decrease of vitamin A.

Conference on asbestos control and replacement for electric utilities: Proceedings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

An EPRI conference on Asbestos Control and Replacement for Electric Utilities was held April 9, 1992 in conjunction with the National Asbestos Council's Environmental Management 192 Conference and Exposition. The high cost and potential liabilities of asbestos removal projects, compounded by concerns over the health effects of asbestos replacement materials, was the main motivation for the conference. The objective of the conference was to assemble guidance and information that will help utilities manage asbestos and to effectively prioritize EPRI research in this area. Ten papers covered such topics as computer-aided asbestos management, utility experience with asbestos management, asbestos monitoring andmore » disposal, and asbestos replacement materials. Utility feedback received at the conference indicates that present and planned EPRI research activities in this area will effectively meet industry needs.« less

DefenseLink.mil - Special Report - Travels With Gates

Science.gov Websites

of Estonia Estonia Defense Secretary Robert M. Gates holds a press conference after the Tallinn High . Sgt. Jerry Morrison Defense Secretary Robert M. Gates holds a press conference after the Tallinn High . Sgt. Jerry Morrison Defense Secretary Robert M. Gates walks with the Prime Minister of Estonia Andrus

The Utilisation of Highly Qualified Personnel. Venice Conference, 25th-27th October 1971.

ERIC Educational Resources Information Center

Organisation for Economic Cooperation and Development, Paris (France).

This document reports the highlights of an international conference designed to study the utilization of highly qualified personnel. Following the opening addresses by various participants, discussion documents and basic reports are presented. Four areas of concern include the state of employment and employment policy, the conditions and aims of…

PREFACE: 5th Baltic Conference on Silicate Materials

NASA Astrophysics Data System (ADS)

Mezinskis, G.; Bragina, L.; Colombo, P.; Frischat, G. H.; Grabis, J.; Greil, P.; Deja, J.; Kaminskas, R.; Kliava, J.; Medvids, A.; Nowak, I.; Siauciunas, R.; Valancius, Z.; Zalite, I.

2011-12-01

Logo This Volume of IOP Conference Series: Materials Science and Engineering presents a selection of the contributions to the 5th Baltic Conference on Silicate Materials (BaltSilica2011) held at Riga Technical University, Riga, Latvia from 23-25 May 2011. The conference was organized by Riga Technical University (Latvia) and Kaunas University of Technology (Lithuania). The series of Baltic conferences on silicate materials was started since 2004: the first conference was held in Riga, Latvia, 2004; the second conference was held in Kaunas, Lithuania 2005; the third was held again in Riga, Latvia, 2007, and the fourth was held in Kaunas, Lithuania 2009. BaltSilica 2011 was attended by around 50 participants from Latvia, Lithuania, Estonia, Germany, Poland, Italy, France, Ukraine and Russia. In comparison with previous silicate materials conferences, the broadening of participating countries is an indication of the interest of scientists, engineers and students to exchange research ideas, latest results, and to find new research topics for cooperation in the fields of silicate, high temperature materials, and inorganic nanomaterials. The scientific programme included 8 invited plenary lectures 23 oral presentations and 25 posters [1]. Scientific themes covered in the conference and in this special issue: Natural and Artificial Stone Materials; Traditional and New Ceramic and Glass-Like Materials; Nanoparticles and Nanomaterials. This volume consists of 23 selected proceeding papers. The Editor of this special issue is grateful to all the contributors to BaltSilica 2011. I am also very grateful to the scientific committee, the local organizing committee, the session chairs, the referees who refereed the submitted articles to this issue, and to students from the Department of Silicate, High Temperature and Inorganic Nanomaterials Technology of the Riga Technical University who ensured the smooth running of the conference. Particular thanks goes to eight plenary speakers who provided interesting findings and thoughtful overviews in the scientific themes of the conference. Special thanks go to Prof., Dr.rer.nat. Günther Heinz Frischat (Germany) who encouraged and supported the organization of these scientific meetings from the very first BaltSilica conferences. With warm regards and best wishes for the next BaltSilica conference. The Conference Chairman Gundars Mezinskis Reference [1] Baltic Conference on Silicate Materials. Book of abstracts of the 5th Baltic Conference on Silicate Materials BaltSilica 2011 : 23-25 May 2011, Riga, Latvia ed G Mezinskis, G Sedmale, J Setina, I Sperberga, L Krage, I Pavlovska, D Andersone (Riga: RTU Publishing House) p 94

Space Network Control Conference on Resource Allocation Concepts and Approaches

NASA Technical Reports Server (NTRS)

Moe, Karen L. (Editor)

1991-01-01

The results are presented of the Space Network Control (SNC) Conference. In the late 1990s, when the Advanced Tracking and Data Relay Satellite System is operational, Space Network communication services will be supported and controlled by the SNC. The goals of the conference were to survey existing resource allocation concepts and approaches, to identify solutions applicable to the Space Network, and to identify avenues of study in support of the SNC development. The conference was divided into three sessions: (1) Concepts for Space Network Allocation; (2) SNC and User Payload Operations Control Center (POCC) Human-Computer Interface Concepts; and (3) Resource Allocation Tools, Technology, and Algorithms. Key recommendations addressed approaches to achieving higher levels of automation in the scheduling process.

Level of autonomy of primary care nurse practitioners.

PubMed

Bahadori, Alex; Fitzpatrick, Joyce J

2009-09-01

The purpose of this descriptive study was to determine the level of autonomy of nurse practitioners (NPs) providing care to patients in a primary care setting. Data were collected from 48 primary care NPs (PCNPs) who attended a state clinical conference. The Dempster Practice Behavior Scale (DPBS) was used to measure the autonomy of the NPs. The total mean score for the DPBS in this study was 127 (SD = 10.25), indicating a very high level of autonomy of the NPs. The Empowerment subscale had the lowest overall mean score, and the Valuation subscale had the highest. There was no statistically significant relationship between level of autonomy and age, years worked as an RN, and years worked as an NP. This study provided evidence that PCNPs are highly autonomous professionals and continue to struggle with empowerment. NPs educationally prepared with a better knowledge of legal and political issues will be better suited to influence healthcare reform. NPs, as autonomous professionals, will be more likely to impact and shape future healthcare policy.

Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.

PubMed

Ramsuran, Veron; Naranbhai, Vivek; Horowitz, Amir; Qi, Ying; Martin, Maureen P; Yuki, Yuko; Gao, Xiaojiang; Walker-Sperling, Victoria; Del Prete, Gregory Q; Schneider, Douglas K; Lifson, Jeffrey D; Fellay, Jacques; Deeks, Steven G; Martin, Jeffrey N; Goedert, James J; Wolinsky, Steven M; Michael, Nelson L; Kirk, Gregory D; Buchbinder, Susan; Haas, David; Ndung'u, Thumbi; Goulder, Philip; Parham, Peter; Walker, Bruce D; Carlson, Jonathan M; Carrington, Mary

2018-01-05

The highly polymorphic human leukocyte antigen ( HLA ) locus encodes cell surface proteins that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner, diversifying allele-specific effects beyond peptide-binding preference. Analysis of 9763 HIV-infected individuals from 21 cohorts shows that higher HLA-A levels confer poorer control of HIV. Elevated HLA-A expression provides enhanced levels of an HLA-A-derived signal peptide that specifically binds and determines expression levels of HLA-E, the ligand for the inhibitory NKG2A natural killer (NK) cell receptor. HLA-B haplotypes that favor NKG2A-mediated NK cell licensing (i.e., education) exacerbate the deleterious effect of high HLA-A on HIV control, consistent with NKG2A-mediated inhibition impairing NK cell clearance of HIV-infected targets. Therapeutic blockade of HLA-E:NKG2A interaction may yield benefit in HIV disease. Copyright © 2017, American Association for the Advancement of Science.

Holding a country countdown to 2015 conference on Millennium Development Goals (MDGs) - the Zambian experience.

PubMed

Mukonka, Victor M; Malumo, Sarai; Kalesha, Penelope; Nambao, Mary; Mwale, Rodgers; Mwinga, Kasonde; Katepa-Bwalya, Mary; Babaniyi, Olusegan; Mason, Elizabeth; Phiri, Caroline; Wamulume, Pauline K

2014-01-21

Initiatives such as the Country Countdown to 2015 Conference on Millennium Development Goals (MDGs) have provided countries with high maternal and child deaths like Zambia a platform to assess progress, discuss challenges and share lessons learnt as a conduit for national commitment to reaching and attaining the MDGs four and five. This paper discusses and highlights the process of holding a successful country countdown conference and shares Zambia's experience with other countries planning to organise country countdown to 2015 Conferences on MDGs.

Maize Homologs of Hydroxycinnamoyltransferase, a Key Enzyme in Lignin Biosynthesis, Bind the Nucleotide Binding Leucine-Rich Repeat Rp1 Proteins to Modulate the Defense Response.

PubMed

Wang, Guan-Feng; He, Yijian; Strauch, Renee; Olukolu, Bode A; Nielsen, Dahlia; Li, Xu; Balint-Kurti, Peter J

2015-11-01

In plants, most disease resistance genes encode nucleotide binding Leu-rich repeat (NLR) proteins that trigger a rapid localized cell death called a hypersensitive response (HR) upon pathogen recognition. The maize (Zea mays) NLR protein Rp1-D21 derives from an intragenic recombination between two NLRs, Rp1-D and Rp1-dp2, and confers an autoactive HR in the absence of pathogen infection. From a previous quantitative trait loci and genome-wide association study, we identified a single-nucleotide polymorphism locus highly associated with variation in the severity of Rp1-D21-induced HR. Two maize genes encoding hydroxycinnamoyltransferase (HCT; a key enzyme involved in lignin biosynthesis) homologs, termed HCT1806 and HCT4918, were adjacent to this single-nucleotide polymorphism. Here, we show that both HCT1806 and HCT4918 physically interact with and suppress the HR conferred by Rp1-D21 but not other autoactive NLRs when transiently coexpressed in Nicotiana benthamiana. Other maize HCT homologs are unable to confer the same level of suppression on Rp1-D21-induced HR. The metabolic activity of HCT1806 and HCT4918 is unlikely to be necessary for their role in suppressing HR. We show that the lignin pathway is activated by Rp1-D21 at both the transcriptional and metabolic levels. We derive a model to explain the roles of HCT1806 and HCT4918 in Rp1-mediated disease resistance. © 2015 American Society of Plant Biologists. All Rights Reserved.

Integration of family planning with poverty alleviation.

PubMed

Peng, P

1996-12-01

The Chinese Communist Central Committee and the State Council aim to solve food and clothing problems among impoverished rural people by the year 2000. This goal was a priority on the agenda of the recent October 1996 National Conference on Poverty Alleviation and Development and the 1996 National Conference of the State Family Planning Commission. Poverty is attributed to rapid population growth and underdevelopment. Poverty is concentrated in parts of 18 large provinces. These provinces are characterized by Family Planning Minister Peng as having high birth rates, early marriage and childbearing, unplanned births, and multiple births. Overpopulation is tied to overconsumption, depletion of resources, deforestation, soil erosion, pollution, shortages of water, decreases in shares of cultivated land, degraded grasslands, and general destruction of the environment. Illiteracy in poor areas is over 20%, compared to the national average of 15%. Mortality and morbidity are higher. Family planning is harder to enforce in poor areas. Pilot programs in Sichuan and Guizhou provinces are promoting integration of family planning with poverty alleviation. Several conferences have addressed the integrated program strategies. Experience has shown that poverty alleviation occurs by controlled population growth and improved quality of life. Departments should "consolidate" their development efforts under Communist Party leadership at all levels. Approaches should emphasize self-reliance and public mobilization. The emphasis should be on women's participation in development. Women's income should be increased. Family planning networks at the grassroots level need to be strengthened simultaneously with increased poverty alleviation and development. The government strategy is to strengthen leadership, mobilize the public, and implement integrated programs.

Maize Homologs of Hydroxycinnamoyltransferase, a Key Enzyme in Lignin Biosynthesis, Bind the Nucleotide Binding Leucine-Rich Repeat Rp1 Proteins to Modulate the Defense Response1

PubMed Central

Wang, Guan-Feng; He, Yijian; Strauch, Renee; Olukolu, Bode A.; Nielsen, Dahlia; Li, Xu; Balint-Kurti, Peter J.

2015-01-01

In plants, most disease resistance genes encode nucleotide binding Leu-rich repeat (NLR) proteins that trigger a rapid localized cell death called a hypersensitive response (HR) upon pathogen recognition. The maize (Zea mays) NLR protein Rp1-D21 derives from an intragenic recombination between two NLRs, Rp1-D and Rp1-dp2, and confers an autoactive HR in the absence of pathogen infection. From a previous quantitative trait loci and genome-wide association study, we identified a single-nucleotide polymorphism locus highly associated with variation in the severity of Rp1-D21-induced HR. Two maize genes encoding hydroxycinnamoyltransferase (HCT; a key enzyme involved in lignin biosynthesis) homologs, termed HCT1806 and HCT4918, were adjacent to this single-nucleotide polymorphism. Here, we show that both HCT1806 and HCT4918 physically interact with and suppress the HR conferred by Rp1-D21 but not other autoactive NLRs when transiently coexpressed in Nicotiana benthamiana. Other maize HCT homologs are unable to confer the same level of suppression on Rp1-D21-induced HR. The metabolic activity of HCT1806 and HCT4918 is unlikely to be necessary for their role in suppressing HR. We show that the lignin pathway is activated by Rp1-D21 at both the transcriptional and metabolic levels. We derive a model to explain the roles of HCT1806 and HCT4918 in Rp1-mediated disease resistance. PMID:26373661

PREFACE: Astronomy at High Angular Resolution 2011: The central kiloparsec in galactic nuclei

NASA Astrophysics Data System (ADS)

Iserlohe, Christof; Karas, Vladimir; Krips, Melanie; Eckart, Andreas; Britzen, Silke; Fischer, Sebastian

2012-07-01

We are pleased to present the proceedings from the Astronomy at High Angular Resolution 2011: The central kiloparsec in galactic nuclei conference. The conference took place in the Physikzentrum of the Deutsche Physikalische Gesellschaft (DPG), Bad Honnef, Germany, from 28 August to 2 September 2011. It was the second conference of this kind, following the Astronomy at High Angular Resolution conference held in Bad Honnef, three years earlier in 2008. The main objective of the conference was to frame the discussion of the broad range of physical processes that occur in the central 100pc of galactic nuclei. In most cases, this domain is difficult to probe through observations. This is mainly because of the lack of angular resolution, the brightness of the central engine and possible obscurations through dust and gas, which play together in the central regions of host galaxies of galactic nuclei within a broad range of activity. The presence of large amounts of molecular and atomic (both neutral and ionized) gas, dust and central engines with outflows and jets implies that the conditions for star formation in these regions are very special, and probably different from those in the disks of host galaxies. Numerous presentations covering a broad range of topics, both theoretical and experimental, those related to research on Active Galactic Nuclei and on a wide range of observed wavelengths were submitted to the Scientific Organizing Committee. Presentations have been grouped into six sessions: The nuclei of active galaxies The Galactic Center The immediate environment of Super Massive Black Holes The physics of nuclear jets and the interaction of the interstellar medium The central 100pc of the nuclear environment Star formation in that region The editors thank all participants of the AHAR 2011 conference for their enthusiasm and their numerous and vivid contributions to this conference. We would especially like to thank John Hugh Seiradakis from the Aristotle University of Thessaloniki in Greece for giving the dinner talk on the most astounding ancient Antikythera mechanism. We would also like to thank Victor Gomer and the staff of the Physikzentrum of the Deutsche Physikalische Gesellschaft in Bad Honnef where the conference took place. Last but not least we would like to thank all unnamed helpers, without whom the organisation of this conference would not have been possible. Financial support for this conference was granted by the Deutsche Forschungsgemeinschaft (DFG) Sonderforschungsbereich project number SFB 956. We also acknowledge support from the European Community Framework Programme 7, Advanced Radio Astronomy in Europe, grant agreement no. 227290. Christof Iserlohe, Vladimir Karas, Melanie Krips, Andreas Eckart, Silke Britzen and Sebastian Fischer The Editors Conference photograph Conference Group Photo, 1 September 2011 The PDF also contains additional photographs from the conference and the Contents of the Proceedings.

Fibre Concrete 2017

NASA Astrophysics Data System (ADS)

2017-09-01

9th international conference on fibre reinforced concretes (FRC), textile reinforced concretes (TRC) and ultra-high performance concretes (UHPC) Preface The Fibre Concrete Conference series is held biennially to provide a platform to share knowledge on fibre reinforced concretes, textile concretes and ultra-high performance concretes regarding material properties and behaviour, technology procedures, topics of long-term behaviour, creep, durability; sustainable aspects of concrete including utilisation of waste materials in concrete production and recycling of concrete. The tradition of Fibre Concrete Conferences started in eighties of the last century. Nowadays the conference is organized by the Department of Concrete and Masonry Structures of the Czech Technical University in Prague, Faculty of Civil Engineering. The 9th International Conference Fibre Concrete 2017 had 109 participants from 27 countries all over the world. 55 papers were presented including keynote lectures of Professor Bažant, Professor Bartoš and Dr. Broukalová. The conference program covered wide range of topics from scientific research to practical applications. The presented contributions related to performance and behaviour of cement based composites, their long-term behaviour and durability, sustainable aspects, advanced analyses of structures from these composites and successful applications. This conference was organized also to honour Professor Zděnek P. Bažant on the occasion of his jubilee and to appreciate his merits and discoveries in the field of fibre reinforced composites, structural mechanics and engineering.

Clinical conferences for physicians: Who sets the agenda?

PubMed

Abakumova, T R; Safina, A F; Ziganshina, L E

2015-01-01

Clinical conferences are generally defined as scheduled events at which practicing physicians themselves present to their colleagues interesting clinical cases, share their new experiences and learn about the latest achievements of medical science and practice. The value of a clinical conference is thought to be in direct communication between physicians, in analysis of topical issues in a given specialty with the aim to improve the quality of care. Speakers based on their own observations and studies reveal the most urgent problems, analyze results and offer potential decisions to their colleagues interested in the same questions. The event format may be different: workshops, highly specialized sections, round tables and seminars with participation of the leading specialists in a given field. These conferences are generally organised by the Ministries and Departments of Health, by leading research and/or educational institutions in the field, by recognised medical centres and other institutions. Recently pharmaceutical companies got actively involved in medical events, acting as sponsors of various scientific conferences and congresses, however threatening the mission of these events [1]. This brings up some uneasy questions: who are the medical conferences for? Who is in charge of setting the conference agenda? Do they contribute to evidence-based medicine; do they contribute to better health? Unfortunately, there is a trend to duplication or multiplication of conferences: various agencies and departments deliver the same conferences, presentations at which are often pre-arranged by pharmaceutical companies and do not have clear scientific novelty, while the conferences themselves have largely transformed into advertising of new pharmaceuticals or new technologies [2]. Pharmaceutical corporations sponsor invited speakers paying for their trips and paying honoraria, organising cocktail parties as part of medical activities. With the help of leading experts with impressive titles serving as speakers at the conferences, pharmaceutical companies are trying to be as close as possible to routine practice of prescribing of certain drugs, manipulating evidence, controlling scientific societies as well as the process of clinical guideline development and publication of research results [3]. The degree of expert involvement depends on their level of influence [4]. We aimed to study how often regular medical practitioners attend these conferences; to analyse who were keynote speakers and where they were coming from; to identify which organizations were responsible for organisation of these conferences and for sending out invitations to these conferences and for disseminating information about them. We summarized all the invitations (printed on paper) received by one regular medical practitioner employed with the outpatient clinical of the city of Kazan for the period of two years (2012-2013). During the study period (2012-2013), a regular medical practitioner received 47 printed paper invitations to scientific conferences: 22 in 2012 and 25 in 2013. The conferences were not distributed evenly over the months of the years. November appeared to be the month with the highest density/number of medical conferences: 7 conferences in 2012 and 10 in 2013. If the distribution was even, then we could calculate the number per month dividing the number per year by 9 active months (excluding July, August and September). This resulted in 2.4 and 2.8 conferences per month. Among these studied conferences 4 were organized by public health agencies: invitation tickets were accompanied by the corresponding official order to organise a conference, issued by the Health Department. Noteworthy, that 2 of these conferences were held in conference rooms of the largest hotels of the city. Forty-one out of 47 medical conferences were sponsored by big pharma: either jointly with the major medical higher educational institutions of the city or plainly by pharmaceutical companies. Seventeen conferences were held during official working hours, in the first half of the day. Not only the logo of the pharmaceutical companies was printed on invitation tickets, but there was also an advert of the promoted pharmaceutical brand.Nine conference invitations contained invitation to dinner. In one of the invitations to a conference on neuroscience it was written: "dinner under the unforgettable music". Two conference invitations contained invitation to a lunch. Programs of 20 conferences (which were included) listed guest lecturers, coming from the leading medical universities in Moscow and St. Petersburg. Opinion leaders' involvement: some of the leading experts acted as speakers from 4 to 7 conferences a month in this sample conference invitations package of a regular polyclinic physician. In 2012-2013 health practitioners were invited to attend medical conferences regularly, at least 2 times a month, with November being the busiest month. The keynote speakers were the opinion leaders from the local medical educational institutions and visitors from Moscow and St. Petersburg; their involvement with the conferences was repetitive. Governmental institutions jointly with big pharma were responsible for organisation of these conferences and attracting audience.Limitations of these observations:Unfortunately, the information on printed-paper conference invitations was not complete because not all tickets have survived. From the interview with the physician we know that in addition to these printed on paper invitations there were many invitations and alerts sent out by e-mail, SMS messages and personal phone calls, making the regularity of these conferences much higher. The physician, who kindly provided this information to us, asked not to be named or thanked in any public presentation of the results of these analyses.

Antigenic relatedness between glycoproteins of human respiratory syncytial virus subgroups A and B: evaluation of the contributions of F and G glycoproteins to immunity.

PubMed Central

Johnson, P R; Olmsted, R A; Prince, G A; Murphy, B R; Alling, D W; Walsh, E E; Collins, P L

1987-01-01

The degree of antigenic relatedness between human respiratory syncytial virus (RSV) subgroups A and B was estimated from antibody responses induced in cotton rats by respiratory tract infection with RSV. Glycoprotein-specific enzyme-linked immunosorbent assays of antibody responses induced by RSV infection demonstrated that the F glycoproteins of subgroups A and B were antigenically closely related (relatedness, R approximately 50%), whereas the G glycoproteins were only distantly related (R approximately 5%). Intermediate levels of antigenic relatedness (R approximately 25%) were seen in neutralizing antibodies from cotton rats infected with RSV of the two subgroups. Immunity against the F glycoprotein of subgroup A, induced by vaccinia-A2-F, conferred a high level of protection which was of comparable magnitude against challenge by RSV of either subgroup. In comparison, immunity against the G glycoprotein of subgroup A, induced by vaccinia-A2-G, conferred less complete, but significant, protection. Importantly, in vaccinia-A2-G-immunized animals, suppression of homologous challenge virus replication was significantly greater (13-fold) than that observed for the heterologous virus. PMID:3305988

Toward Ultraintense Compact RBS Pump for Recombination 3.4 nm Laser via OFI

NASA Astrophysics Data System (ADS)

Suckewer, S.; Ren, J.; Li, S.; Lou, Y.; Morozov, A.; Turnbull, D.; Avitzour, Y.

In our presentation we overview progress we made in developing a new ultrashort and ultraintensive laser system based on Raman backscattering (RBS) amplifier /compressor from time of 10th XRL Conference in Berlin to present time of 11th XRL Conference in Belfast. One of the main objectives of RBS laser system development is to use it for pumping of recombination X-ray laser in transition to ground state of CVI ions at 3.4 nm. Using elaborate computer code the processes of Optical Field Ionization, electron energy distribution, and recombination were calculated. It was shown that in very earlier stage of recombination, when electron energy distribution is strongly non-Maxwellian, high gain in transition from the first excited level n=2 to ground level m=1 can be generated. Adding large amount of hydrogen gas into initial gas containing carbon atoms (e.g. methane, CH4) the calculated gain has reached values up to 150-200 cm-2 Taking into account this very encouraging result, we have proceed with arrangement of experimental setup. We will present the observation of plasma channels and measurements of electron density distribution required for generation of gain at 3.4 nm.

Proceedings of National Nutrition Education Conference (6th, Washington, D.C., November 2-4, 1971).

ERIC Educational Resources Information Center

Department of Agriculture, Washington, DC.

The conference provided an opportunity for nutritionists and workers in allied professions at the local, State, and national levels to come together to identify and consider effective techniques for working with youth in the development of food habits. Participants raised and explored some of the youth-oriented problems related to nutrition,…

Online Clinical Post-Conference, Face-to-Face Clinical Postconference: Effects on Critical Thinking in Associate Degree Nursing Students

ERIC Educational Resources Information Center

Ebersole-Berkstresser, Kristie Anne

2013-01-01

Nurse educators, at every level of pre-licensure nursing education, are charged with developing critical thinking skills within their students. Post-clinical conference is one teaching strategy that nurse educators can employ to help promote the development of critical thinking skills in pre-licensure nursing students. However, traditional…

Association of Small Computer Users in Education (ASCUE) Summer Conference. Proceedings (27th, North Myrtle Beach, South Carolina, June 12-16, 1994).

ERIC Educational Resources Information Center

Huston, Rick, Ed.; Armel, Donald, Ed.

Topics addressed by 40 papers from a conference on microcomputers include: developing a campus wide computer ethics policy; integrating new technologies into professional education; campus computer networks; computer assisted instruction; client/server architecture; competencies for entry-level computing positions; auditing and professional…

NAWeb 99: What Works and Why. International Conference on Web-Based Learning (5th, New Brunswick, Canada, October 2-5, 1999).

ERIC Educational Resources Information Center

Hall, Richard, Ed.

This proceedings of the Fifth International Conference on Web-Based Learning, NAWeb 99, includes the following papers: "Coordinating Different Masters and Customers: Dalhousie's Diploma in Disability Management Program"; "The Design, Development, Implementation, and Evaluation of a Graduate Level Course for Teaching Web-Based Instruction";…

HRD and Employee Outcomes. Symposium 42. [Concurrent Symposium Session at AHRD Annual Conference, 2000.

ERIC Educational Resources Information Center

2000

This document contains three papers from a symposium on human resource development (HRD) and employee outcomes that was conducted as part of a HRD conference. "The Impact of Participating in Human Resource Development Activities on Individuals' Job Level and Income" (Tim de Jong, Bob Witziers, Martin Mulder) presents the results of a…

NASA Public Affairs and NUANCE Lab News Conference at Reno-Stead Airport.

NASA Image and Video Library

2016-10-19

News Conference following the test of Unmanned Aircraft Systems Traffic Management (UTM) technical capability Level 2 (TCL2) at Reno-Stead Airport, Nevada. Parimal Kopardekar, NASA Ames Senior Engineer for Ait Transportation Systems gave an overview of UTM (Left). Tom Wilczek, Aerospace and Defence industry representative and Nevada Govenor's Office of Economic Development (Right).

ED-MEDIA 2001 World Conference on Educational Multimedia, Hypermedia & Telecommunications. Proceedings (13th, Tampere, Finland, June 25-30, 2001).

ERIC Educational Resources Information Center

Montgomerie, Craig, Ed.; Viteli, Jarmo, Ed.

This 13th annual ED-MEDIA conference serves as a multidisciplinary forum for the discussion of the latest research, developments, and applications of multimedia, hypermedia, and telecommunications for all levels of education. This document contains papers from attendees representing more than 60 countries, with keynote speakers representing both…

Integrated tools for natural resources inventories in the 21st century

Treesearch

M. Hansen; T. Burk

2000-01-01

Includes 96 papers presented at the conference Integrated Tools for Natural Resources Inventories in the 21st Century, August 16-20, 1998, in Boise, Idaho, USA. This conference drew several hundred forest inventory and related professionals from multiple organizational levels and over 30 foreign countries. Topics covered include those related to natural resource...

Reading, Writing, Thinking: Proceedings of the 13th European Conference on Reading

ERIC Educational Resources Information Center

Pandis, Meeli, Ed.; Ward, Angela, Ed.; Mathews, Samuel R., Ed.

2005-01-01

This collection of papers presented at the 13th European Conference on Reading brings together a vast range of knowledge, research, and perspectives about literacy and its complex processes. The book explores topics including: (1) Literacy and critical thinking; (2) Working with learners at all levels, from young children to adolescents to…

EdMedia 2012: World Conference on Educational Multimedia, Hypermedia and Telecommunications. Proceedings (Denver, Colorado, June 26-29, 2012)

ERIC Educational Resources Information Center

Amiel, Tel, Ed.; Wilson, Brent, Ed.

2012-01-01

The Association for the Advancement of Computing in Education (AACE) is an international, non-profit educational organization. The Association's purpose is to advance the knowledge, theory, and quality of teaching and learning at all levels with information technology. "EdMedia 2012: World Conference on Educational Multimedia, Hypermedia and…

Putting the Pieces Together. Proceedings of the PEPNet 2008 Biennial Conference (Columbus, Ohio, April 15-18, 2008)

ERIC Educational Resources Information Center

PEPNet 2, 2008

2008-01-01

"Putting the Pieces Together" provided a distinctive opportunity for professionals to interact with their colleagues to learn more about effective practices and strategies for meeting the needs of deaf or hard of hearing students at the secondary and postsecondary levels. Conference participants engaged is sessions that focused on…

NASA Public Affairs and NUANCE Lab News Conference at Reno-Stead Airport.

NASA Image and Video Library

2016-10-19

News Conference following the test of Unmanned Aircraft Systems Traffic Management (UTM) technical capability Level 2 (TCL2) at Reno-Stead Airport, Nevada. Parimal Kopardekar, NASA Ames Senior Engineer for Ait Transportation Systems gave an overview of UTM (Left). Maril Mora (Podium), President / CEO of the Reno -Tahoe Airport Authority welcomes NASA and Partners.

Proceedings of the 20th International Conference on Defects in Semiconductors Held in Berkeley, CA, USA, 26-30 July 1999

DTIC Science & Technology

1999-07-30

National Science Foundation through the GOALI Program, under grant number ECS-9705134. References [1] T. Ogino, M. Aoki, Jap. J. Appl. Phys. 19 (1980... pulled from molten silicon through a graphite slot for solar cell production in economical way [8]. It was observed that EFG silicon contains high...samples the closest resem- blance to our observations is found in the Au-Hj config- uration where the --/- gold acceptor level is pulled down in the

Fatty Acid Synthesis Gene Variants and Breast Cancer Risk: A Study within the European Prospective Investigation into Cancer and Nutrition

DTIC Science & Technology

2005-02-01

refined carbohydrates, is associated with high incidence of breast cancer in women. Excess energy intake causes elevated blood levels of glucose and...confer increased breast cancer susceptibility. In a series of 46 breast cancer cases, we are systematically searching the coding and regulatory regions of...of excess energy in the form of triglycerides , produced either from the diet fatty acids or from those synthesized de novo. Excess energy intake and

International Conference on the Physics of Semiconductors (17th) Held in San Francisco, California on August 6-10, 1984

DTIC Science & Technology

1984-09-30

experimental probe of the Landau level density of states, which we find to be distinctly non -gaussian and in qualitative agreement with theoretical predictions...dispersion on the cleaved Si(111)2xi surface. For good single domain 2x1 surfaces different experimental groups agree on a highly dispersive dangling-bond...work underlies the operation of new devices proposed II] and realized experimentally : a gate controlled microwave generator (2,3J and a charge

Molecular Biology: Conference on Genetic Engineering Techniques (2nd) Held in London (United Kingdom) on 20-21 November 1986.

DTIC Science & Technology

1987-05-27

system in Chinese t-PA to be a serine protease of 327 amino ovary hamster cells. Precise yields from acids in length. The protein appears, high-level...ham- ster or mouse cell line, allowing the differentiation of human and hamster or ________ mouse clones by hybridization with total human DNA or...appropriate lo- functional protein when transferred into cation downstream of a strong promoter in baby hamster kidney (BHK) cells or rat place of one or

High Level Synthesis in ASP

DTIC Science & Technology

1986-08-19

Thus in and g (X, Y) A and X share one element, and B and Y share another. Assigning a value to A (via its storage element) also assigns that value to X...functionality as well as generate it. i4 29 References [Ada] ’ADA as a Hardware Description Language: An Initial Report’ M.R. Bar- bacci, S. Grout, G ...1985; pp. 303-320. (Expert] ’An Expert-System Paradigm for Design’ Forrest D. Brewer, Daniel D. Gajski ; 23rd Design Automation Conference, 1986; pp

Partnerships and Linkages for Success. Enhancing the Employment Potential of Persons with Disabilities. Report of the Los Angeles Regional Conference (September 25-27, 1989).

ERIC Educational Resources Information Center

Walker, Sylvia, Ed.; Asbury, Charles A., Ed.

This report provides highlights from a conference that focused on strategies for assisting minority youth with disabilities to face labor market challenges. An introduction lists conference objectives. Section I contains a profile of the high school students with disabilities who participated in the workshops. The profile includes demographic…

Proceedings of the International Conference on Educational Data Mining (EDM) (5th, Chania, Greece, June 19-21, 2012)

ERIC Educational Resources Information Center

International Educational Data Mining Society, 2012

2012-01-01

The 5th International Conference on Educational Data Mining (EDM 2012) is held in picturesque Chania on the beautiful Crete island in Greece, under the auspices of the International Educational Data Mining Society (IEDMS). The EDM 2012 conference is a leading international forum for high quality research that mines large data sets of educational…

2009 Gordon Research Conference, Applied and Environmental Microbiology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dubilier, Nicole

The topic of the 2009 Gordon Conference on Applied and Environmental Microbiology is: From Single Cells to the Environment. The Conference will present and discuss cutting-edge research on applied and environmental microbiology with a focus on understanding interactions between microorganisms and the environment at levels ranging from single cells to complex communities. The Conference will feature a wide range of topics such as single cell techniques (including genomics, imaging, and NanoSIMS), microbial diversity at scales ranging from clonal to global, environmental 'meta-omics', biodegradation and bioremediation, metal - microbe interactions, animal microbiomes and symbioses. The Conference will bring together investigators whomore » are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Some poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with extensive discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an ideal setting for scientists from different disciplines to exchange ideas, brainstorm and discuss cross-disciplinary collaborations.« less

INTRODUCTION: The 8th International Conference on Vacuum Ultraviolet Radiation Physics

NASA Astrophysics Data System (ADS)

Nilsson, Per Olof; Hedin, Lars

1987-01-01

The VUV conferences series The international conferences on vacuum ultraviolet radiation physics started in 1962, and are now being held every third year. VUV-8 took place at Lund University, August 4-8, 1986. VUV-9 will be arranged at the University of Hawaii, USA, August 14-18, 1989, with Prof. C S Fadley as conference chairman. Chairman of the international advisory board for the period 1986-89 is Prof. L Hedin. The theme of the series can be summarized as experimental and theoretical progress in research fields utilizing the interaction of VUV radiation with matter. The topics cover broad areas within atomic and molecular physics, solid state physics and VUV instrumentation. The conferences emphasize interdisciplinary aspects. To these belong common experimental techniques as, e.g., synchrotron radiation instrumentation, and common theoretical foundations for the description of photon interactions with matter. The VUV-8 conference The VUV-8 conference in Lund was attended by 300 participants from 26 countries. An address list of the participants is given at the end of this volume. There were 33 invited papers given as plenary or key-note talks. As many as 229 posters were presented; 49 of them were also given orally. These numbers are typical for the VUV conferences, except for the number of posters, which was unusually large. In the conference planning the poster sessions were stressed, and particular care was taken to provide a good atmosphere at these sessions. Thus the posters were kept up during the whole conference, coffee was served in the hail with the posters and there were convenient places to sit down close to the posters. Considering the wide scope of the conference it was necessary to emphasize a limited number of topics of high current interest and importance. Thus besides traditional topics, several rapidly expanding fields were discussed in special sessions. At VUV-8 there were the following sessions. Theory of atoms and molecules photoabsorption and -ionization of atoms and molecules and related phenomena multiphoton and other dynamical processes plasma physics VUV lasers time resolved spectroscopy instrumentation for VUV radiation synchrotron radiation centres solid state spectroscopy dynamical processes involving localized levels fundamental aspects of photoemission spin-polarized photoemission inverse photoemission semiconductors organic materials adsorbates Proceedings of VUV-8 The present volume contains most of the invited papers (28 out of 33). Regarding the contributed papers, over 50 are now being published in regular issues of PHYSICA SCRIPTA. These papers will also appear in a reprint volume, PHYSICA SCRIPTA RS4, which soon will be available. Abstracts of invited and contributed papers appeared in three conference volumes as follows: Volume I: Atomic and molecular physics. Instrumentation. Volume II: Solid state physics. Volume III: Post deadline papers. These books have been registered in an international data base and can thus be cited as published documents. Copies may be received from the conference secretary.* Acknowledgements We would like to thank our sponsors, which are listed on the following page, the members of the international program committee, and all others who helped in the planning of the program. Above all we like to thank those who worked with the local organization. Due to their dedicated efforts the conference ran very smoothly with a pleasant atmosphere.

Medicine: business or profession?

PubMed

Zhai, Xiaomei

2012-06-01

As professionals, doctors have a contractual relationship with society that trains them and confers on them exclusive power to practice medical care. In the contract, power and responsibility should be balanced. When the power is conferred by society to a profession, the profession should take responsibility for society, including the provision of high quality services, and maintain high standard principled conduct and integrity.

Computers for the Disabled. Proceedings of the Discovery '83 Conference (Minneapolis, Minnesota, September 12-14, 1983).

ERIC Educational Resources Information Center

Roehl, Janet E., Ed.

These proceedings provide 30 papers from a conference to highlight a frontier area in serving the disabled--microcomputers--which blends two disciplines, vocational rehabilitation and special education. Keynote addresses are "High Tech/High Touch: Making Good on the Promise" (Fenderson); "Curbcuts and Computers: Providing Access to Computers and…

Vitamin E confers cytoprotective effects on cardiomyocytes under conditions of heat stress by increasing the expression of metallothionein.

PubMed

Wang, Xiaowu; Dong, Wenpeng; Yuan, Binbin; Yang, Yongchao; Yang, Dongpeng; Lin, Xi; Chen, Changfu; Zhang, Weida

2016-05-01

Heat stress (HS) is commonly used to refer to the heat load that an individual is subjected to due to either metabolic heat, or environmental factors, including high temperatures and high humidity levels. HS has been reported to affect and even damage the functioning of various organs; overexposure to high temperatures and high humidity may lead to accidental deaths. It has been suggested that the cardiovascular system is primarily targeted by exposure to HS conditions; the HS-induced dysfunction of cardiomyocytes, which is characterized by mitochondrial dysfunction, may result in the development of cardiovascular diseases. The excessive production of reactive oxygen species (ROS) also participates in mitochondrial dysfunction. However, effective methods for the prevention and treatment of mitochondrial and cardiovascular dysfunction induced by exposure to HS are lacking. In the present study, we hypothesized that vitamin E (VE), an antioxidant, is capable of preventing oxidative stress and mitochondrial injury in cardiomyocytes induced by exposure to HS. The results revealed that pre‑treatment with VE increased the expression of metallothionein (MT), which has previously been reported to confer cytoprotective effects, particularly on the cardiovascular system. Pre-treatment with VE restored mitochondrial function in cardiomyocytes under conditions of HS by increasing the expression of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), nuclear respiratory factor 1 (NRF-1) and mitochondrial transcription factor A (TFAM), and by increasing adenosine triphosphate (ATP) levels. Furthermore, pre-treatment with VE decreased the production of ROS, which was induced by exposure to HS and thus exerted antioxidant effects. In addition, pre-treatment with VE attenuated oxidative stress induced by exposure to HS, as demonstrated by the increased levels of antioxidant enzymes [superoxide dismutase (SOD) and glutathione (GSH)], and by the decreased levels of markers of oxidative injury [malondialdehyde (MDA) and lactate dehydrogenase (LDH)]. Taken together, these findings suggest that pre-treatment with VE can prevent mitochondrial dysfunction and oxidative stress in cardiomyocytes induced by exposure to HS, by increasing the expression of MT.

Conference on asbestos control and replacement for electric utilities: Proceedings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

An EPRI conference on Asbestos Control and Replacement for Electric Utilities was held April 9, 1992 in conjunction with the National Asbestos Council`s Environmental Management 192 Conference and Exposition. The high cost and potential liabilities of asbestos removal projects, compounded by concerns over the health effects of asbestos replacement materials, was the main motivation for the conference. The objective of the conference was to assemble guidance and information that will help utilities manage asbestos and to effectively prioritize EPRI research in this area. Ten papers covered such topics as computer-aided asbestos management, utility experience with asbestos management, asbestos monitoring andmore » disposal, and asbestos replacement materials. Utility feedback received at the conference indicates that present and planned EPRI research activities in this area will effectively meet industry needs.« less

High p95HER2/HER2 Ratio Associated With Poor Outcome in Trastuzumab-Treated HER2-Positive Metastatic Breast Cancer NCCTG N0337 and NCCTG 98-32-52 (Alliance).

PubMed

Chumsri, Saranya; Sperinde, Jeff; Liu, Heshan; Gligorov, Joseph; Spano, Jean-Philippe; Antoine, Martine; Moreno Aspitia, Alvaro; Tan, Winston; Winslow, John; Petropoulos, Christos J; Chenna, Ahmed; Bates, Michael; Weidler, Jodi Marie; Huang, Weidong; Dueck, Amylou; Perez, Edith A

2018-03-12

Purpose: p95HER2 is a truncated form of HER2 that confers resistance to trastuzumab in vitro , but clinical results have been conflicting to date. Given that p95HER2 levels correlate with total HER2 expression levels, which confer better outcomes, we sought to evaluate the p95HER2/HER2 ratio in the North Central Cancer Treatment Group N0337 and N98-32-52 trials. Experimental Design: The HERmark assay and VeraTag technology (Monogram Biosciences) were used to measure total HER2 and p95HER2 expression levels in 91 patient samples. Results: In the multivariate model, increasing total HER2 level was significantly associated with longer (OS; HR, 0.33; P = 0.002) and decreasing p95HER2 level was significantly associated with longer OS (HR, 4.2; P = 0.01). Total HER2 expression level was significantly associated with longer progression-free survival (PFS) (HR, 0.57; P = 0.04), whereas p95HER2 level was not (HR, 1.7; P = 0.25). However, there was a positive association between p95HER2 and total HER2 expression levels ( R 2 = 0.48; P < 0.001). Consistent with our hypothesis, the ratio of p95HER2/HER2 was significantly associated with worsening PFS (HR, 1.7; P = 0.04) and OS (HR, 2.8; P = 0.002). Patients with the highest tertile of p95HER2/HER2 values had significantly less favorable PFS (HR, 1.8; P = 0.06) and OS (HR, 2.3; P = 0.02). Conclusions: A high p95HER2/HER2 ratio identified patients with metastatic breast cancer with poor outcomes on trastuzumab-based therapies. Further investigation of the p95HER2/HER2 ratio as a potential prognostic or predictive biomarker for HER2-targeted therapy is warranted. Clin Cancer Res; 1-6. ©2018 AACR. ©2018 American Association for Cancer Research.

PREFACE: International Conference on Advancement in Science and Technology 2012 (iCAST): Contemporary Mathematics, Mathematical Physics and their Applications

NASA Astrophysics Data System (ADS)

Ganikhodjaev, Nasir; Mukhamedov, Farrukh; Hee, Pah Chin

2013-04-01

The 4th International Conference on the Advancement of Science and Technology 2012 (iCAST 2012), with theme 'Contemporary Mathematics, Mathematical Physics and their Applications', took place in Kuantan, Malaysia, from Wednesday 7 to Friday 9 November 2012. The conference was attended by more than 100 participants, and hosted about 160 oral and poster papers by more than 140 pre-registered authors. The key topics of the 4th iCAST 2012 include Pure Mathematics, Applied Mathematics, Theoretical/Mathematical Physics, Dynamical Systems, Statistics and Financial Mathematics. The scientific program was rather full since after the Keynote and Invited Talks in the morning, four parallel sessions ran every day. However, according to all attendees, the program was excellent with a high level of talks and the scientific environment was fruitful; thus all attendees had a creative time. The conference aimed to promote the knowledge and development of high-quality research in mathematical fields concerned with the application of other scientific fields as well as modern technological trends in physics, chemistry, biology, medicine, economics, sociology and environmental sciences. We would like to thank the Keynote and the Invited Speakers for their significant contributions to 4th iCAST 2012. We would also like to thank the members of the International Scientific Committee and the members of the Organizing Committee. We cannot end without expressing our many thanks to International Islamic University Malaysia and our sponsors for their financial support . This volume presents selected papers which have been peer-reviewed. The editors hope that it may be useful and fruitful for scholars, researchers, and advanced technical members of the industrial laboratory facilities for developing new tools and products. Guest Editors Nasir Ganikhodjaev, Farrukh Mukhamedov and Pah Chin Hee The PDF contains the committee lists, board list and biographies of the plenary speakers.

Helicobacter pylori Adaptation In Vivo in Response to a High-Salt Diet

PubMed Central

Loh, John T.; Gaddy, Jennifer A.; Algood, Holly M. Scott; Gaudieri, Silvana; Mallal, Simon

2015-01-01

Helicobacter pylori exhibits a high level of intraspecies genetic diversity. In this study, we investigated whether the diversification of H. pylori is influenced by the composition of the diet. Specifically, we investigated the effect of a high-salt diet (a known risk factor for gastric adenocarcinoma) on H. pylori diversification within a host. We analyzed H. pylori strains isolated from Mongolian gerbils fed either a high-salt diet or a regular diet for 4 months by proteomic and whole-genome sequencing methods. Compared to the input strain and output strains from animals fed a regular diet, the output strains from animals fed a high-salt diet produced higher levels of proteins involved in iron acquisition and oxidative-stress resistance. Several of these changes were attributable to a nonsynonymous mutation in fur (fur-R88H). Further experiments indicated that this mutation conferred increased resistance to high-salt conditions and oxidative stress. We propose a model in which a high-salt diet leads to high levels of gastric inflammation and associated oxidative stress in H. pylori-infected animals and that these conditions, along with the high intraluminal concentrations of sodium chloride, lead to selection of H. pylori strains that are most fit for growth in this environment. PMID:26438795

Proceedings of the ninth national conference on undergraduate research, 1995. Volume 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yearout, R.D.

1995-07-01

The Ninth National Conference on Undergraduate Research (NCUR 95) was held at Union College in Schenectady, New York. This annual celebration of undergraduate scholarly activity continues to elicit strong nation-wide support and enthusiasm among both students and faculty. Attendance was nearly 1,650, which included 1,213 student oral and poster presenters. For the second year in a row, many student papers had to be rejected for presentation at NCUR due to conference size limitations. Thus, submitted papers for presentation at NCUR 95 were put through a careful review process before acceptance. Those students who have been selected to have their papermore » appear in these Proceedings have been through yet a second review process. As a consequence, their work has been judged to represent an impressive level of achievement at the undergraduate level. Volume 2 contains papers related to Engineering and Mathematics (41 papers) and Physical Science (18 papers).« less

Development of the Ultra-Light Stretched Lens Array

NASA Technical Reports Server (NTRS)

O'Neill, M. J.; McDanal, A. J.; George, P. J.; Piszczor, M. F.; Edwards, D. L.; Botke, M. M.; Jaster, P. A.; Brandhorst, H. W.; Eskenazi, M.I.; Munafo, Paul M. (Technical Monitor)

2002-01-01

At the last IEEE (Institute of Electrical and Electronics Engineers) PVSC (Photovoltaic Specialists Conference), the new stretched lens array (SLA) concept was introduced. Since that conference, the SLA team has made significant advances in the SLA technology, including component level improvements, array level optimization, space environment exposure testing, and prototype hardware fabrication and evaluation. This paper will describe the evolved version of the SLA, highlighting the improvements in the lens, solar cell, rigid panel structure, and complete solar array wing. The near term SLA will provide outstanding wing level performance: greater than 180 W/kg specific power, greater than 300 W/sq m power density, greater than 300 V operational voltage, and excellent durability in the space environment.

Foreword: 18th Aps-Sccm and 24th Airapt

NASA Astrophysics Data System (ADS)

Collins, Gilbert; Moore, David S.; Yoo, Choong-Shik

2014-05-01

This second joint conference between the APS Topical Group on Shock Compression of Condensed Matter and the International Association for the Advancement of High Pressure Science and Technology (AIRAPT) demonstrates that static and dynamic compression of condensed matter continues to be a vibrant field of science and engineering. It is also by its nature an interdisciplinary field, incorporating chemistry, materials science, solid mechanics, plasma physics, and condensed matter physics, and utilizes theoretical, computational, and experimental tools. Recent years have brought about many advances in loading platforms, diagnostics, and computations that are leading to the emergence of many new avenues of research. These advances are also breathing new life into traditional topics such as equations of state, phase transformations, and chemistry at extreme conditions. The plenary lectures by Gennady Kanel, Karl Syassen, David Ceperley, Jon Eggert, Duck Young Kim, and Richard Kraus spanned the disciplines of static and dynamic high pressure physics and illustrated the breadth of the field. They also showed that interesting and important problems remain for researchers of the future to solve. The main guiding principal in the organization of this conference was to intertwine static and dynamical experimental alongside computational and theoretical studies of similar materials. To achieve this goal, we arranged the conference to include static, dynamic, and computational components in the same sessions, quite often taking presenters out of their comfort zone. The three special sessions on Deep Carbon Budget (organized by Giulia Galli and Rus Hemley), High Energy Density Materials (organized by Raymond Jeanloz and Jon Eggert), and Dynamic Response of Materials (organized by Yogendra Gupta and John Sarrao) furthered this guiding principal. We also endeavored to represent the breadth of static and dynamic high pressure science and technology, notably beyond that done at national laboratories. To this end, a significant fraction of the plenary, invited and contributed presentations showcased work done in academia, defense laboratories and industry, as well as internationally. Although travel distance and visa issues always present difficulties, the conference had strong representation from a record number of international participants, including sizable groups from Russia and China (thanks to Tony Zocher and Frank Cherne), as well as Japan, the United Kingdom, France, Canada, Germany, Israel, and Italy. It is our sincere hope that international interactions that occurred at the conference will lead to further collaborations in the future. Finally, we strived to increase student participation at the conference. Through the leadership of Scott Alexander and his committee, a new all-day student symposium was held the day before the main conference, with only student attendees and presenters, in order to acclimate the students to conference participation and help them network with their peers. In cooperation with the APS Topical Group and the AIRAPT and with additional support from DTRA and the AWE, the conference was able to provide financial assistance to a large number of students to attend the conference and present their research. This aid helped increase the number of student attendees significantly over previous conferences. Finally, the conference sponsored a networking lunch for students and representatives from a number of laboratories and other institutions, which was well attended. Seattle proved itself to be an excellent venue for the conference. The international flavor of the city provided ample dining options and numerous activity choices outside of the conference sessions. The major international airport made travel as easy as possible, as Seattle is a convenient central location for attendees from Europe and Asia. The conference was truly a team effort with critical contributions from many individuals. We deeply appreciate their contributions to the success of the conference and the publication of these proceedings. Gilbert (RIP) Collins David S Moore Choong-Shik Yoo

Exogenous Gene Transmission of Isocitrate Dehydrogenase 2 Mimics Ischemic Preconditioning Protection.

PubMed

Kolb, Alexander L; Corridon, Peter R; Zhang, Shijun; Xu, Weimin; Witzmann, Frank A; Collett, Jason A; Rhodes, George J; Winfree, Seth; Bready, Devin; Pfeffenberger, Zechariah J; Pomerantz, Jeremy M; Hato, Takashi; Nagami, Glenn T; Molitoris, Bruce A; Basile, David P; Atkinson, Simon J; Bacallao, Robert L

2018-04-01

Ischemic preconditioning confers organ-wide protection against subsequent ischemic stress. A substantial body of evidence underscores the importance of mitochondria adaptation as a critical component of cell protection from ischemia. To identify changes in mitochondria protein expression in response to ischemic preconditioning, we isolated mitochondria from ischemic preconditioned kidneys and sham-treated kidneys as a basis for comparison. The proteomic screen identified highly upregulated proteins, including NADP+-dependent isocitrate dehydrogenase 2 (IDH2), and we confirmed the ability of this protein to confer cellular protection from injury in murine S3 proximal tubule cells subjected to hypoxia. To further evaluate the role of IDH2 in cell protection, we performed detailed analysis of the effects of Idh2 gene delivery on kidney susceptibility to ischemia-reperfusion injury. Gene delivery of IDH2 before injury attenuated the injury-induced rise in serum creatinine ( P <0.05) observed in controls and increased the mitochondria membrane potential ( P <0.05), maximal respiratory capacity ( P <0.05), and intracellular ATP levels ( P <0.05) above those in controls. This communication shows that gene delivery of Idh2 can confer organ-wide protection against subsequent ischemia-reperfusion injury and mimics ischemic preconditioning. Copyright © 2018 by the American Society of Nephrology.

Mechanisms of naturally evolved ethanol resistance in Drosophila melanogaster

PubMed Central

Fry, James D.

2014-01-01

The decaying fruit in which Drosophila melanogaster feed and breed can contain ethanol in concentrations as high as 6–7%. In this cosmopolitan species, populations from temperate regions are consistently more resistant to ethanol poisoning than populations from the tropics, but little is known about the physiological basis of this difference. I show that when exposed to low levels of ethanol vapor, flies from a tropical African population accumulated 2–3 times more internal ethanol than flies from a European population, giving evidence that faster ethanol catabolism by European flies contributes to the resistance difference. Using lines differing only in the origin of their third chromosome, however, I show that faster ethanol elimination cannot fully explain the resistance difference, because relative to African third chromosomes, European third chromosomes confer substantially higher ethanol resistance, while having little effect on internal ethanol concentrations. European third chromosomes also confer higher resistance to acetic acid, a metabolic product of ethanol, than African third chromosomes, suggesting that the higher ethanol resistance conferred by the former might be due to increased resistance to deleterious effects of ethanol-derived acetic acid. In support of this hypothesis, when ethanol catabolism was blocked with an Alcohol dehydrogenase mutant, there was no difference in ethanol resistance between flies with European and African third chromosomes. PMID:25392459

PREFACE: 2nd International Conference on Mathematical Modeling in Physical Sciences 2013 (IC-MSQUARE 2013)

NASA Astrophysics Data System (ADS)

2014-03-01

The second International Conference on Mathematical Modeling in Physical Sciences (IC-MSQUARE) took place at Prague, Czech Republic, from Sunday 1 September to Thursday 5 September 2013. The Conference was attended by more than 280 participants and hosted about 400 oral, poster, and virtual presentations while counted more than 600 pre-registered authors. The second IC-MSQUARE consisted of different and diverging workshops and thus covered various research fields where Mathematical Modeling is used, such as Theoretical/Mathematical Physics, Neutrino Physics, Non-Integrable Systems, Dynamical Systems, Computational Nanoscience, Biological Physics, Computational Biomechanics, Complex Networks, Stochastic Modeling, Fractional Statistics, DNA Dynamics, Macroeconomics. The scientific program was rather heavy since after the Keynote and Invited Talks in the morning, three parallel sessions were running every day. However, according to all attendees, the program was excellent with high level of talks and the scientific environment was fruitful, thus all attendees had a creative time. We would like to thank the Keynote Speaker and the Invited Speakers for their significant contribution to IC-MSQUARE. We also would like to thank the Members of the International Advisory and Scientific Committees as well as the Members of the Organizing Committee. Further information on the editors, speakers and committees is available in the attached pdf.

CALL FOR PAPERS: 13th International Conference on Force and Mass Measurement

NASA Astrophysics Data System (ADS)

1992-01-01

10 14 May 1993, Helsinki Fair Centre, Finland Scope of the Conference The Conference reports and reviews the state of the art and future trends in force and mass measurements in science and industry. Emphasis is on the applications of new methods, current problems in calibration and quality control, as well as on advancements in new sensor technologies and industrial application of force and mass measurements. Main Themes and Topics 1. The state of the art and development trends in force and mass measurements Development and stability of high level mass standards Mass comparators and force standard machine New research topics in mass and force 2. Calibration and quality control Calibration methods Estimation of uncertainties and classification of accuracies Relations between calibration, testing and quality control Requirements for quality control Verification of weighing instruments and their main devices 3. Application of force and mass measurements Automatic weighing Mass flow measurements Quality control in process industry Sensor technologies Practical applications Special applications in industry, trade, etc. Deadline for submission of abstracts: 30 June 1992. For further information please contact: Finnish Society of Automation, Asemapäällikönkatu 12C, SF-00520 HELSINKI, Finland Phone: Int. +3580 1461 644, Fax: Int. +3580 1461 650

Scientific program and abstracts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gerich, C.

1983-01-01

The Fifth International Conference on High-Power Particle Beams is organized jointly by the Lawrence Livermore National Laboratory and Physics International Company. As in the previous conferences in this series, the program includes the following topics: high-power, electron- and ion-beam acceleration and transport; diode physics; high-power particle beam interaction with plasmas and dense targets; particle beam fusion (inertial confinement); collective ion acceleration; particle beam heating of magnetically confined plasmas; and generation of microwave/free-electron lasers.

High-Level Resistance of Staphylococcus aureus to β-Lactam Antibiotics Mediated by Penicillin-Binding Protein 4 (PBP4).

PubMed

Hamilton, Stephanie M; Alexander, J Andrew N; Choo, Eun Ju; Basuino, Li; da Costa, Thaina M; Severin, Anatoly; Chung, Marilyn; Aedo, Sandra; Strynadka, Natalie C J; Tomasz, Alexander; Chatterjee, Som S; Chambers, Henry F

2017-06-01

Penicillin-binding protein 4 (PBP4), a nonessential, low-molecular-weight penicillin-binding protein of Staphylococcus aureus , has been implicated in low-level resistance to β-lactam antibiotics, although the mechanism is unknown. Mutations in PBP4 and its promoter were identified in a laboratory-generated mutant strain, CRB, which expresses high-level resistance to β-lactams, including resistance to the new-generation cephalosporins active against methicillin-resistant strains of S. aureus These mutations did not appreciably alter the β-lactam antibiotic binding affinity of purified recombinant mutant PBP4 compared to that of wild-type PBP4. Compared to the susceptible parent strain, COLnex, the CRB strain produces a highly cross-linked cell wall peptidoglycan, indicative of increased transpeptidase activity. The pbp4 promoter mutation of CRB was associated with greatly increased amounts of PBP4 in membranes compared to those in the COLnex parent. Replacement of the native promoter of COLnex with the mutant promoter of CRB resulted in increased amounts of PBP4 in membranes and a highly cross-linked cell wall. PBP4 can be repurposed to provide essential transpeptidase activity in vivo and confer high-level resistance to β-lactam antibiotics, such as ceftobiprole and ceftaroline. Copyright © 2017 American Society for Microbiology.

High-Level Resistance of Staphylococcus aureus to β-Lactam Antibiotics Mediated by Penicillin-Binding Protein 4 (PBP4)

PubMed Central

Hamilton, Stephanie M.; Alexander, J. Andrew N.; Choo, Eun Ju; Basuino, Li; da Costa, Thaina M.; Severin, Anatoly; Chung, Marilyn; Aedo, Sandra; Strynadka, Natalie C. J.; Tomasz, Alexander; Chatterjee, Som S.

2017-01-01

ABSTRACT Penicillin-binding protein 4 (PBP4), a nonessential, low-molecular-weight penicillin-binding protein of Staphylococcus aureus, has been implicated in low-level resistance to β-lactam antibiotics, although the mechanism is unknown. Mutations in PBP4 and its promoter were identified in a laboratory-generated mutant strain, CRB, which expresses high-level resistance to β-lactams, including resistance to the new-generation cephalosporins active against methicillin-resistant strains of S. aureus. These mutations did not appreciably alter the β-lactam antibiotic binding affinity of purified recombinant mutant PBP4 compared to that of wild-type PBP4. Compared to the susceptible parent strain, COLnex, the CRB strain produces a highly cross-linked cell wall peptidoglycan, indicative of increased transpeptidase activity. The pbp4 promoter mutation of CRB was associated with greatly increased amounts of PBP4 in membranes compared to those in the COLnex parent. Replacement of the native promoter of COLnex with the mutant promoter of CRB resulted in increased amounts of PBP4 in membranes and a highly cross-linked cell wall. PBP4 can be repurposed to provide essential transpeptidase activity in vivo and confer high-level resistance to β-lactam antibiotics, such as ceftobiprole and ceftaroline. PMID:28373193

Conference on Continental margin mass wasting and Pleistocene sea-level changes, August 13-15, 1980

USGS Publications Warehouse

Folger, David W.; Hathaway, J.C.

1987-01-01

A conference on Continental Margin Mass Wasting and Pleistocene Sea-Level Changes was held in Woods Hole, Mass., August 13-15, 1980. Forty-seven participants, representing many government, academic, and industrial organizations, discussed the current state of knowledge of the features of marine mass wasting and of the interrelations of factors influencing them. These factors include sediment source, composition, textures, sedimentation rates, climatic and sea-level changes, gas and gas hydrate (clathrate) contents of sediments, geotechnical characteristics, oceanographic and morphological factors, ground-water processes, and seismic events. The part played by these factors in the processes and features of mass movement and the engineering considerations imposed by the emplacement of manmade structures on the sea floor were considered vital to the evaluation of hazards involved in offshore exploration and development. The conference concluded with a call for bold programs to establish the probability of occurrence and the quantitative importance of these factors and to devise more reliable means of measurement, particularly in place, of the characteristics of the sediment and features involved.

An impetus to move the field forward: a look at child and adolescent mental health services participants' views of the prospects for change.

PubMed

Haynes, Katherine Taylor

2010-03-01

In September 2009 key stakeholders convened for the invitation-only Child and Adolescent Mental Health Services (CAMHS): Issues and Solutions conference. This paper provides a brief synopsis of the key high points and issues in children's mental health (CMH) and describes the process by which participants collectively brainstormed the priorities and distilled the four key foci for the new action agenda, and summarizes the key outcomes. In addition, this paper offers participants' perspectives on the conference. Based on observation notes and post-conference qualitative interviews, this paper reports conference participants' feedback on the event, their views on the prospects for change generated by the conference and suggestions for follow-up.

International Conference on Education in Sparsely Populated Rural Areas (7th, Golspie High School, County of Sutherland, Scotland, July 9-17, 1974). Interskola Golspie '74 Report.

ERIC Educational Resources Information Center

Aberdeen Coll. of Education (Scotland).

Papers from a conference series initiated in the Aberdeen College of Education in 1968 and recently held in Golspie, Scotland (July 1974), address policy oriented recommendations relative to rural education. This conference report is intended to serve as a useful source of ideas; as background information on international rural educational…

The Fourth R: Reasoning. Proceedings of the Conference of the University/Urban Schools National Task Force (4th, San Juan, Puerto Rico, November 11 & 12, 1982).

ERIC Educational Resources Information Center

Bossone, Richard M., Ed.

This booklet contains proceedings of the Fourth Conference of the University/Urban Schools National Task Force. The conference was held to present information about four programs designed to help high school students to sharpen their reasoning skills. Criteria for program development state that: (1) the program can be taught to teachers in a…

SIAM conference on applications of dynamical systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-01-01

A conference (Oct.15--19, 1992, Snowbird, Utah; sponsored by SIAM (Society for Industrial and Applied Mathematics) Activity Group on Dynamical Systems) was held that highlighted recent developments in applied dynamical systems. The main lectures and minisymposia covered theory about chaotic motion, applications in high energy physics and heart fibrillations, turbulent motion, Henon map and attractor, integrable problems in classical physics, pattern formation in chemical reactions, etc. The conference fostered an exchange between mathematicians working on theoretical issues of modern dynamical systems and applied scientists. This two-part document contains abstracts, conference program, and an author index.

SIAM conference on applications of dynamical systems. Abstracts and author index

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-12-31

A conference (Oct.15--19, 1992, Snowbird, Utah; sponsored by SIAM (Society for Industrial and Applied Mathematics) Activity Group on Dynamical Systems) was held that highlighted recent developments in applied dynamical systems. The main lectures and minisymposia covered theory about chaotic motion, applications in high energy physics and heart fibrillations, turbulent motion, Henon map and attractor, integrable problems in classical physics, pattern formation in chemical reactions, etc. The conference fostered an exchange between mathematicians working on theoretical issues of modern dynamical systems and applied scientists. This two-part document contains abstracts, conference program, and an author index.

Expanding your horizons in science and mathematics

NASA Technical Reports Server (NTRS)

1985-01-01

Through the presentation of its Expanding Your Horizons in Science and Mathematics career education conferences for secondary school young women, the Math/Science Network continues its efforts to remove the educational, psychological, and cultural barriers which prevent women from entering math-and science-based careers. The Expanding Your Horizons conferences were presented on 77 college, university and high school campuses across the United States. This year, these unique one day conferences reached 15,500 students, 3,000 parents and educators, and involved 3,000 career women who volunteered their services as conference planners, workshop leaders, speakers, and role models.

PREFACE: Quark Matter 2006 Conference

NASA Astrophysics Data System (ADS)

Ma, Yu-Gang; Wang, En-Ke; Cai, Xu; Huang, Huan-Zhong; Wang, Xin-Nian; Zhu, Zhi-Yuan

2007-07-01

The Quark Matter 2006 conference was held on 14 20 November 2006 at the Shanghai Science Hall of the Shanghai Association of Sciences and Technology in Shanghai, China. It was the 19th International Conference on Ultra-Relativistic Nucleus Nucleus Collisions. The conference was organized jointly by SINAP (Shanghai Institute of Applied Physics, Chinese Academy of Sciences (CAS)) and CCNU (Central China Normal University, Wuhan). Over 600 scientists from 32 countries in five continents attended the conference. This is the first time that China has hosted such a premier conference in the field of relativistic heavy-ion collisions, an important event for the Chinese high energy nuclear physics community. About one half of the conference participants are junior scientists—a clear indication of the vigor and momentum for this field, in search of the fundamental nature of the nuclear matter at extreme conditions. Professor T D Lee, honorary chair of the conference and one of the founders of the quark matter research, delivered an opening address with his profound and philosophical remarks on the recent discovery of the nature of strongly-interacting quark-gluon-plasma (sQGP). Professor Hongjie Xu, director of SINAP, gave a welcome address to all participants on behalf of the two hosting institutions. Dr Peiwen Ji, deputy director of the Mathematics and Physics Division of the Natural Science Foundation of China (NSFC), also addressed the conference participants and congratulated them on the opening of the conference. Professor Mianheng Jiang, vice president of the Chinese Academy of Sciences (CAS), gave a concise introduction about the CAS as the premier research institution in China. He highlighted continued efforts at CAS to foster international collaborations between China and other nations. The Quark Matter 2006 conference is an example of such a successful collaboration between high energy nuclear physicists in China and other nations all over the world. The scientific program of the conference began with an overview of high energy nuclear physics in China by Professor Wenqing Shen, vice president of the National Natural Science Foundation of China. Professor Shen highlighted many contributions made by the Chinese scientists in both theory and experiment. Dr Nick Samios, former director of Brookhaven National Laboratory (BNL), gave a vivid account of the early years of RHIC and recent accomplishments. Highlights of the conference include new results from RHIC at BNL and SPS (Super Proton Synchrotron) at CERN (European Organization for Nuclear Research). Many experimental results reported at the conference support the notion that the quark-gluon matter at RHIC behaves like a perfect liquid with minimum viscosity to entropy ratio. There were 15 plenary sessions which covered 54 plenary talks, 12 parallel sessions and 1 poster session. A total of 320 abstracts were submitted to the conference out of which 124 were selected for oral presentation and the rest were assigned to the poster session. Talks and posters in the conference covered a broad range of experimental and theoretical progress in ultra-relativistic heavy-ion collisions, which includes new evidence of sQGP, jet quenching and heavy quark energy loss, heavy-ion collision phenomenology, quantum field theory at finite temperature and/or density, and relevant areas of astrophysics and plasma physics. The Quark Matter 2006 conference coincided with the 80th birthday of Professor T D Lee. A special reception was held in the banquet hall of the Shanghai Grand Theatre to celebrate Professor Lee's birthday and to honor his great contributions to physics, in particular, to the development of high energy nuclear physics research in China. We would like to thank the members of the International Advisory Committee for providing valuable advice on a variety of matters, from the general structure of the conference to the selection of the plenary speakers and selection of abstracts for oral presentations. Professors T Hemmick, H Satz, D T Son and N Xu gave excellent pedagogical lectures in the pre-conference student symposium and their efforts were greatly appreciated. The Shanghai Association of Science and Technology (SAST) and the staff of the Shanghai science hall provided valuable assistance and services during the conference. The conference would not have run so smoothly without their professional dedication. We also thank Professor Wenqing Shen, Chairman of the SAST, for his many valuable suggestions to the conference organizers and for providing close cooperation with SAST staff. We thank members of the Local Organizing Committee for many useful suggestions and help. We would like to express our special appreciation for the tireless efforts by many local staff who worked very hard to make this conference a success. Dr Xiang-Zhou Cai, Mrs Wei Zhou and Mrs Yang Shen undertook many duties to coordinate and organize the local services. Dr Kun Wang took responsibility of the conference web page. Dr Wei Guo, Dr Wendong Tian, Mr Chunwang Ma and Mrs Wanyan Qian organized student volunteers for the conference. Without their help and dedication this conference could not have been such a success. The Quark Matter 2006 conference has received substantial financial support from many organizations, including the Chinese Academy of Sciences (CAS), the National Natural Science Foundation of China (NSFC), the Ministry of Education of China (MOE), Shanghai Science and Technology Committee (SSTC), Chinese Nuclear Physics Society (CNPS), Shanghai Institute of Applied Physics (SINAP), Central China Normal University (CCNU), China Center of Advanced Science and Technology (CCAST), Brookhaven National Laboratory (BNL), Lawrence Berkeley National Laboratory (LBNL), European Laboratory for Particle Physics (CERN), and Journal of Physics G: Nuclear and Particle Physics (IOP Publishing).

Proceedings of the Nordic Conference on Mathematics Teaching (NORMA-94) Lahti 1994. Research Report 141.

ERIC Educational Resources Information Center

Pehkonen, Erkki, Ed.

This report contains papers from the Nordic Conference on Mathematics Teaching (NORMA-94). The first three papers are plenary talks aimed at giving the participants an opportunity to form a coherent view of the new theories of learning. The themes of the paper sessions addressed a variety of topics on different levels from elementary school to…

76 FR 52716 - Advisory Committee on Reactor Safeguards; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-23

... Register on Thursday, October 21, 2010 (75 FR 65038-65039). Thursday, September 8, 2011, Conference Room T2... low-level waste disposal and site- specific analysis. 1:15 p.m.-3:15 p.m.: Safety Evaluation Report... U.S.C. 552b(c)(4).] Friday, September 9, 2011, Conference Room T2-B1, 11545 Rockville Pike...

Australian Educational Computing: Journal of the Australian Council for Computers in Education. Volume 8, Special Conference Edition.

ERIC Educational Resources Information Center

Nanlohy, Phil, Ed.

1993-01-01

The 43 papers in this collection were presented at the Australian Council for Computers in Education 1993 annual conference. The papers focus on research and scholarship in the use of computers at the elementary, secondary, and higher education levels. The papers address the following aspects of the use of computers in education: (1) theoretical…

Second Forest Vegetation Simulator Conference; February 12-14, 2002; Fort Collins, CO.

Treesearch

Nicholas L. Crookston; Robert N. Havis

2002-01-01

The Forest Vegetation Simulator (FVS) is a computer program that projects the development of forest stands in the United States and British Columbia, Canada. The proceedings of the second FVS conference, held in Fort Collins, CO, includes 34 papers dealing with applications of FVS that range from the stand-level through full-scale landscape analyses. Forecasts ranging...

Annual NASSGP/NCHELP Research Network Conference Proceedings (5th, Denver, Colorado, May 25-27, 1988).

ERIC Educational Resources Information Center

Webster, Jeff, Ed.

This volume presents papers from a 1988 conference on collegiate student financial aid which focused on trends in the cost of higher education, student loan defaults, trends in borrowing, the impact of congressional legislation, and state-level financial aid research. The papers are grouped in five sections corresponding to the five topics, and…

The National Curriculum--Moving into Focus? Papers from the LEAU National Conference (Liverpool, England, April 14-15, 1989).

ERIC Educational Resources Information Center

Thomas, David, Ed.

The University of Liverpool's Evaluation and Assessment Unit (LEAU) organized a national conference on the growth, development, and potential of the National Curriculum. The National Curriculum consists of 10 subjects, each defined by attainment targets, programs of study, and attainment levels. These subjects are to be drawn up by working groups…

[Educational Quality Indicators: Taking Stock.] Proceedings of the Conference (Los Angeles, California, October 12-13, 1989).

ERIC Educational Resources Information Center

CRESST Evaluation Comment, 1989

1989-01-01

An overview of an international conference held on the campus of the University of California at Los Angeles (UCLA) to take stock of the development and use of educational quality indicator systems at the local, state, national, and international levels is provided. Major implications and findings of the education summit held at the University of…

Annual Conference on Drug-Free Schools and Communities Proceedings (4th, Falls Church, Virginia, June 11-15, 1990).

ERIC Educational Resources Information Center

Office of Elementary and Secondary Education, Washington, DC. School Improvement Programs.

This publication summarizes the presentations at individual and group sessions of a conference called to facilitate a broad exchange of concepts and experiences among those individuals and organizations most closely involved with Drug-Free Schools and Communities Programs at the national, state, and local levels. It is intended to highlight key…

Proceedings of the Conference on Nutrition and Mental Retardation (Ann Arbor, Michigan, February 10-11, 1971).

ERIC Educational Resources Information Center

Springer, Ninfa Saturnino, Ed.

The conference, planned primarily for nutritionists and dieticians, dealt with the role of nutrition in the prevention and management of mental retardation. Proceedings include an overview of mental retardation, an examination of nutrition manpower needs in the fields of mental health and mental retardation on both the national and state levels,…

What Is Good Writing? Proceedings of a Conference at the University of Connecticut (Storrs, Connecticut, December 6, 1980).

ERIC Educational Resources Information Center

Sheidley, William E., Ed.; And Others

The focus of the conference proceedings in this booklet was evaluation of student writing at various levels and in various fields. The booklet contains a schedule of activities; a description of the morning session, which included a panel discussion on evaluating writing in college freshman composition courses; examples of students' papers, with…

Spruce-fir management and spruce budworm; SAF region VI technical conference

Treesearch

Daniel Schmitt; ed.

1985-01-01

Presents a technical update of the management of spruce-fir forests. Integrated management of eastern spruce budworm is not yet a reality. The ecological, social, and economic knowledge needed to develop an integrated management system is not available. The conference was designed to move individuals to a higher level of spruce budworm management in the eastern spruce-...

Selected Papers from the Mokakit Conference "Establishing Pathways to Excellence in Indian Education" (1st, Ontario, Canada, July 25-27, 1984).

ERIC Educational Resources Information Center

McCue, Harvey A., Ed.

This volume contains 11 selected papers from the first Mokakit conference on Indian education in Canada. Mokakit, a Blackfoot word meaning "to strive for wisdom," was selected as the name of the sponsoring organization, which promotes the participation of Indians at all levels of educational research. Papers include: (1) "Locally…

PtrA/NINV, an alkaline/neutral invertase gene of Poncirus trifoliata, confers enhanced tolerance to multiple abiotic stresses by modulating ROS levels and maintaining photosynthetic efficiency.

PubMed

Dahro, Bachar; Wang, Fei; Peng, Ting; Liu, Ji-Hong

2016-03-29

Alkaline/neutral invertase (A/N-INV), an enzyme that hydrolyzes sucrose irreversibly into glucose and fructose, is essential for normal plant growth,development, and stress tolerance. However, the physiological and/or molecular mechanism underpinning the role of A/N-INV in abiotic stress tolerance is poorly understood. In this report, an A/N-INV gene (PtrA/NINV) was isolated from Poncirus trifoliata, a cold-hardy relative of citrus, and functionally characterized. PtrA/NINV expression levels were induced by cold, salt, dehydration, sucrose, and ABA, but decreased by glucose. PtrA/NINV was found to localize in both chloroplasts and mitochondria. Overexpression of PtrA/NINV conferred enhanced tolerance to multiple stresses, including cold, high salinity, and drought, as supported by lower levels of reactive oxygen species (ROS), reduced oxidative damages, decreased water loss rate, and increased photosynthesis efficiency, relative to wild-type (WT). The transgenic plants exhibited higher A/N-INV activity and greater reducing sugar content under normal and stress conditions. PtrA/NINV is an important gene implicated in sucrose decomposition, and plays a positive role in abiotic stress tolerance by promoting osmotic adjustment, ROS detoxification and photosynthesis efficiency. Thus, PtrA/NINV has great potential to be used in transgenic breeding for improvement of stress tolerance.

Common variants in the PARL and PINK1 genes increase the risk to leprosy in Han Chinese from South China.

PubMed

Wang, Dong; Zhang, Deng-Feng; Feng, Jia-Qi; Li, Guo-Dong; Li, Xiao-An; Yu, Xiu-Feng; Long, Heng; Li, Yu-Ye; Yao, Yong-Gang

2016-11-23

Leprosy is a chronic infectious and neurological disease caused by Mycobacterium leprae, an unculturable pathogen with massive genomic decay and dependence on host metabolism. We hypothesized that mitochondrial genes PARL and PINK1 would confer risk to leprosy. Thirteen tag SNPs of PARL and PINK1 were analyzed in 3620 individuals with or without leprosy from China. We also sequenced the entire exons of PARL, PINK1 and PARK2 in 80 patients with a family history of leprosy by using the next generation sequencing technology (NGS). We found that PARL SNP rs12631031 conferred a risk to leprosy (P adjusted  = 0.019) and multibacillary leprosy (MB, P adjusted  = 0.020) at the allelic level. rs12631031 and rs7653061 in PARL were associated with leprosy and MB (dominant model, P adjusted  < 0.05) at the genotypic level. PINK1 SNP rs4704 was associated with leprosy at the genotypic level (P adjusted  = 0.004). We confirmed that common variants in PARL and PINK1 were associated with leprosy in patients underwent NGS. Furthermore, PARL and PINK1 could physically interact with each other and were involved in the highly connected network formed by reported leprosy susceptibility genes. Together, our results showed that PARL and PINK1 genetic variants are associated with leprosy.

Keeping the Teacher at Arm's Length: Student Resistance in Writing Conferences in Two High School Classrooms

ERIC Educational Resources Information Center

Consalvo, Annamary; Maloch, Beth

2015-01-01

The purpose of this paper is to explore a subset of findings taken from yearlong qualitative study of writing conferences in two diversely populated, urban high school classrooms. Drawing on multiple data sources, we used case study and discourse analytic methods to follow two focal students across the year in order to examine instructional and…

High Performance Work and Learning Systems: Crafting a Worker-Centered Approach. Proceedings of a Conference (Washington, D.C., September 1991).

ERIC Educational Resources Information Center

Marschall, Daniel, Ed.

A consensus that unions must develop coherent and comprehensive policies on new work systems and continuous learning in order to guide local activities, was the central theme of this conference on the interrelated issues of the high performance work organization. These proceedings include the following presentations: "Labor's Stake in High…

Genome-wide identification of QTLs conferring high-temperature adult-plant (HTAP) resistance to stripe rust (Puccinia striiformis f. sp. tritici) in wheat

USDA-ARS?s Scientific Manuscript database

High-temperature adult-plant (HTAP) resistance to stripe rust (caused by Puccinia striiformis f. sp. tritici) is a durable type of resistance in wheat. The objective of this study was to identify quantitative trait loci (QTL) conferring HTAP resistance to stripe rust in a population consisting of 16...

Real-Time, General-Purpose, High-Speed Signal Processing Systems for Underwater Research. Proceedings of a Working Level Conference held at Supreme Allied Commander, Atlantic, Anti-Submarine Warfare Research Center (SACLANTCEN) on 18-21 September 1979. Part 1. Sessions I to III.

DTIC Science & Technology

1979-12-01

intelligent graphics terminals in real-tim processing S (e) 5-1 to 5-9 MIel ita|ger The application of high-speed processors to propagation e.piriamnts...interface SACLANTCEN CP-25 5-2 M IM M STEIGER: Intelligent graphics terminals The less desirable features of the terminal are listed below. reiatively small...hours. Dismantling of the equipment is normally performed in less than one-half hour and often while waiting to clear customs. Transportation of the

The genetic basis of adaptive pigmentation variation in Drosophila melanogaster

PubMed Central

Pool, John E.; Aquadro, Charles F.

2009-01-01

In a broad survey of Drosophila melanogaster population samples, levels of abdominal pigmentation were found to be highly variable and geographically differentiated. A strong positive correlation was found between dark pigmentation and high altitude, suggesting adaptation to specific environments. DNA sequence polymorphism at the candidate gene ebony revealed a clear association with the pigmentation of homozygous third chromosome lines. The darkest lines sequenced had nearly identical haplotypes spanning 14.5 kilobases upstream of the protein-coding exons of ebony. Thus, natural selection may have elevated the frequency of an allele that confers dark abdominal pigmentation by influencing the regulation of ebony. PMID:17614900

Cutting Edge Research in Homeopathy: HRI's second international research conference in Rome.

PubMed

Tournier, Alexander L; Roberts, E Rachel

2016-02-01

Rome, 3rd-5th June 2015, was the setting for the Homeopathy Research Institute's (HRI) second conference with the theme 'Cutting Edge Research in Homeopathy'. Attended by over 250 delegates from 39 countries, this event provided an intense two and a half day programme of presentations and a forum for the sharing of ideas and the creation of international scientific collaborations. With 35 oral presentations from leaders in the field, the scientific calibre of the programme was high and the content diverse. This report summarises the key themes underpinning the cutting edge data presented by the speakers, including six key-note presentations, covering advancements in both basic and clinical research. Given the clear commitment of the global homeopathic community to high quality research, the resounding success of both Barcelona 2013 and Rome 2015 HRI conferences, and the dedicated support of colleagues, the HRI moves confidently forward towards the next biennial conference. Copyright © 2015.

Proceedings: Conference on asbestos control and replacement for electric utilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

An EPRI conference on Asbestos Control and Replacement for Electric Utilities was held April 6--7, 1993 in conjunction with the Environmental Information Association`s (formerly National Asbestos Council) Environmental Management `93 Conference and Exposition. The high cost and potential liabilities of asbestos removal projects, compounded by concerns over the health effects of asbestos replacement materials, was the main motivation for the conference. The objective of the conference was to assemble guidance and information that will help utilities manage asbestos and to effectively prioritize EPRI research in this area. Eleven papers covered such topics as changes in the Environmental Protection Agency`s (EPA)more » ban on asbestos, utility experience with asbestos management and abatement, asbestos monitoring and disposal, and asbestos replacement materials. Utility feedback received at the conference indicates that present and planned EPRI research activities in this area will effectively meet industry needs.« less

The Spirit of OMERACT: Q Methodology Analysis of Conference Characteristics Valued by Delegates.

PubMed

Flurey, Caroline A; Kirwan, John R; Hadridge, Phillip; Richards, Pamela; Grosskleg, Shawna; Tugwell, Peter S

2015-10-01

To identify the major features of OMERACT meetings as valued by frequent participants and to explore whether there are groups of participants with different opinions. Using Q methodology (a qualitative and quantitative approach to grouping people according to subjective opinion), participants (who attended more than 1 OMERACT conference) sorted 66 statements relating to the "spirit of OMERACT" according to level of agreement across a normal distribution grid. Data were examined using Q factor analysis. Of 226 potential participants, 105 responded (46%). All participants highly ranked the focus on global standardization of methods, outcome measures, data-driven research, methodological discussion, and international collaboration. Four factors describing the "spirit of OMERACT" were identified: "Evidence not eminence" (n = 31) valued the data- and evidence-driven research above personality and status; "Collaboration and collegiality" (n = 19) valued the international and cross-stakeholder collaboration, interaction, and collegiality; "Equal voices, equal votes, common goals" (n = 12) valued equality in discussion and voting, with everyone striving toward the same goal; "principles and product, not process" (n = 8) valued the principles of focusing on outcome measures and the product of guiding clinical trials, but were unsure whether the process is necessary to reach this. The factors did not segregate different stakeholder groups. Delegates value different elements of OMERACT, and thus the "spirit of OMERACT" encompasses evidence-based research, collaboration, and equality, although a small group are unsure whether the process is necessary to achieve the end result. Q methodology may prove useful for conference organizers to identify their delegates' different needs to tailor conference content.

Beijing: a conference of commitments?

PubMed

Davis, S

1996-05-01

The author of this article holds the view that the Declaration and Platform for Action at the UN Fourth World Conference on Women held in Beijing in 1995 was the product of the most highly participatory process ever organized under the auspices of the UN. The Declaration and Platform expressed the strongest views on gender equality, empowerment, and justice that governments have ever endorsed. These documents were the consolidation of gains made by women in previous UN conferences. The 135-page Platform can be used at all levels of decision making. Governments and international can be held accountable for its provisions. The Platform exposes the problems violence and exploitation against women and girls as well as the revelation that environmental destruction is due to an unsustainable pattern of consumption and production, particularly in developed countries. Conference participants included about 3000 nongovernmental groups (NGOs). The Women's Linkage Caucus and WEDO served to facilitate the advocacy process by providing briefings on text still under negotiation and providing on-line recommendations from the 1995 and 1994 Commission on the Status of Women preparatory committee meetings. A scoreboard that tracked government's commitment at the 1995 preparatory committee meetings was reinstated in Beijing. The information was conveyed on the Internet. The European Union is credited with diluting the language about government commitment to the Platform. Governments are still given responsibility for implementation, and the need for political will is stressed (paragraph 293). Paragraph 297 indicates the process for implementation of the Platform and coordination with NGOs. Although the Platform recognizes the importance of women's groups and other NGOs, the responsibility for implementation is still given to governments.

Understanding Resident Learning Preferences Within an Internal Medicine Noon Conference Lecture Series: A Qualitative Study

PubMed Central

Sawatsky, Adam P.; Zickmund, Susan L.; Berlacher, Kathryn; Lesky, Dan; Granieri, Rosanne

2014-01-01

Background The lecture remains the most common approach for didactic offerings in residency programs despite conflicting evidence about the effectiveness of this format. Objective The purpose of this study was to explore the perspectives of internal medicine residents toward conferences held in the lecture format. Methods The investigators invited internal medicine residents (N  =  144) to participate in focus groups discussing their perspectives about noon conference lectures. The investigators used a semistructured guide to ask about motivations for attendance and effectiveness of noon conferences, transcribed the recordings, coded the discussions, and analyzed the results. Results Seven focus groups with a total of 41 residents were held. This identified 4 major domains: (1) motivations for attendance; (2) appropriate content; (3) effective teaching methods; and (4) perspectives on active participation. Residents' motivations were categorized into external factors, including desire for a break and balance to their workload, and intrinsic attributes, including the learning opportunity, topic, and speaker. Appropriate content was described as clinically relevant, practical, and presenting a balance of evidence. Identified effective teaching methods included shorter teaching sessions focused on high-yield learning points structured around cases and questions. While active participation increases residents' perceived level of stress, the benefits of this format include increased attention and learning. Conclusions This study furthers our knowledge of the learning preferences of internal medicine residents within the changing environment of residency education and can be used in conjunction with principles of adult learning to reform how we deliver core medical knowledge. PMID:24701307

Improving the quality of healthcare for children: implementing the results of the AHSR research agenda conference.

PubMed Central

Halfon, N; Schuster, M; Valentine, W; McGlynn, E

1998-01-01

OBJECTIVE: To describe the rationale, development, content, and results of the AHSR-sponsored conference on developing a research agenda focused on improving the quality of care for children. DATA SOURCES AND METHODS: Planning documents, background papers, and conference proceedings. PRINCIPAL FINDINGS: The conference developed the research agenda focused on (1) monitoring the health of children; (2) evaluating the efficacy and effectiveness of health services for children; (3) assessing the quality of healthcare provided to children; (4) improving the quality of healthcare within health systems; (5) assessing the performance of community systems for children; (6) exploring the impact of different financial incentives on the provision of pediatric healthcare; and (7) developing and disseminating clinical practice guidelines and other information to physicians, families, and consumers. Specific issues and research questions in each area are also presented. Strategies for implementing the research agenda are presented and include: (1) expanding the child health services research workforce; (2) developing child healthcare quality improvement research centers; (3) conducting research in specific high-priority areas; (4) focusing research on improving the health of vulnerable populations; (5) improving child health data and collection systems at the national level; (6) developing better community health monitoring for children; (7) building and supporting research networks and a consortium of research users; and (8) developing a coordinated interagency federal effort to advance this agenda and to provide accountability for its completion. CONCLUSION: The proposed research agenda should be a national priority so that all Americans can be assured that children are receiving the best quality of care that the United States can provide. PMID:9776945

The Seventh Annual National Conference of Black Physics Students

NASA Technical Reports Server (NTRS)

Crawley, Gerard M.

1993-01-01

The National Conference of Black Physics Students began in 1986 when several Black physics graduate students at MIT and Harvard decided to address the 'pipeline problem' of African Americans in physics by organizing a conference for Black physics undergraduates. The goals of the conference were: (1) to develop a network within the Black physics community, (2) to make Black students in physics, particularly at graduate level, aware of academic and professional opportunities and (3) to bring important issues and developments in the field to the attention of these students. We are pleased to announce the Seventh Annual National Conference of Black Physics Students held February 12 and 13, 1993 served the largest population of students so far. The largest conference previous to this one hosted 150 students. We registered and prepared for 240 students with 210 actually attenting. We received so many qualified abstracts for technical talks by students that instead of NCBPS's tradition of 3-4 student presentations, we ran 4 parallel sessions in different rooms with 4-5 presentations in each room. In response to comments from previous conferences, the program contained 3 workshop/discussion sessions. The topics for the interactive discussion workshops were: 'Getting Ready for Graduate School,' 'How to Succeed in Graduate School,' and 'Issues Facing Black Scientists.'

Protistology Conferences: The Beginnings. The First International Protozoology Conference (Prague 1961) and the Tribute to Otto Jírovec, its Spiritual Father.

PubMed

Vávra, Jiří

2018-01-27

Two events have helped to shape protozoology/protistology as a specific scientific discipline. The first such event was the creation of the Society of Protozoologists in the U.S. in 1947 (and of its Journal of Protozoology, first published in 1954), the second event was the First International Conference on Protozoology, held in 1961 in Prague. The history of the Society of Protozoologists was comprehensively treated by Corliss (1998); the history of the Prague Conference is presented here as reminiscences and personal interpretation of events of the author, who was one of the conference organizers and a member of the organization committee. Special attention is given to the personality and scientific accomplishments of Otto Jírovec, the 1961 conference spiritual father and president. It is concluded that the Prague Conference, while establishing the tradition of protistology meetings, helped protistology to attain its present status as a fundamental science discipline, which discovers and interprets the web of life at one of its, basic, "microbial" levels. Protists literally permeate the earth biosphere and in a way represent the "dark matter" of the living world, still awaiting many discoveries. © 2018 The Author(s) Journal of Eukaryotic Microbiology © 2018 International Society of Protistologists.

Families with Limited English Proficiency Receive Less Information and Support in Interpreted ICU Family Conferences

PubMed Central

Thornton, J. Daryl; Pham, Kiemanh; Engelberg, Ruth A.; Jackson, J. Carey; Curtis, J. Randall

2009-01-01

Objective Family communication is important for delivering high quality end-of-life care in the ICU, yet little research has been conducted to describe and evaluate clinician-family communication with non-English speaking family members. We assessed clinician-family communication during ICU family conferences involving interpreters and compared it to conferences without interpreters. Design Cross-sectional descriptive study. Setting Family conferences in the ICU’s of four hospitals during which discussions about withdrawing life support or delivery of bad news were likely to occur. Participants 70 family members from 10 interpreted conferences and 214 family members from 51 non-interpreted conferences. Nine different physicians led interpreted conferences and 36 different physicians led non-interpreted conferences. Measurements All 61 conferences were audiotaped. We measured the duration of time that families, interpreters, and clinicians spoke during the conference and we tallied the number of supportive statements issued by clinicians in each conference. Results The mean conference time was 26.3 ± 13 minutes for interpreted and 32±15 minutes for non-interpreted conferences (p=0.25). The duration of clinician speech was 10.9 ± 5.8 minutes for interpreted conferences and 19.6 ± 10.2 minutes for non-interpreted conferences (p=0.001). The amount of clinician speech as a proportion of total speech time was 42.7% in interpreted conferences and 60.5% in non-interpreted conferences (p=0.004). Interpreter speech accounted for 7.9 ± 4.4 minutes and 32% of speech in interpreter conferences. Interpreted conferences contained fewer clinician statements providing support for families, including valuing families’ input (p=0.01), easing emotional burdens (p<0.01), and active listening (p<0.01). Conclusions This study suggests that families with non-English speaking members may be at increased risk of receiving less information about their loved one’s critical illness as well as less emotional support from their clinicians. Future studies should identify ways to improve communication with, and support for, non-English speaking families of critically ill patients. PMID:19050633

Report to the International Global Atmospheric Chemistry Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reisdorf, Jill; Wiedinmyer, Christine

IGAC’s mission is to facilitate atmospheric chemistry research towards a sustainable world. This is achieved through IGAC’s three focal activities: fostering community, building capacity, and providing leadership. A key component to achieving IGAC’s mission is its developing early career program. These scientists join an international network early in their career that puts the cogs in motion to further facilitate atmospheric chemistry research at an international level for years to come. IGAC’s Science Conference is a primary mechanism for IGAC to build cooperation and disseminate scientific information across its international community. The first IGAC Science Conference was held in 1993 in Eilat,more » Israel. Since then, IGAC has successfully held fourteen science conferences, consistently becoming a biennial conference starting in 2002. The biennial IGAC Science Conference is regarded as THE international conference on atmospheric chemistry and participation in the conference is typically in the range of 350-650 participants. Since 2004, IGAC has included an Early Career Scientists Program as part of the conference to foster the next generation of scientists. IGAC believes, and has seen, that by allowing scientists to form an international network of colleagues early in their career that future international collaborations in atmospheric chemistry are enhanced. The 2016 IGAC Science Conference Early Career Program consisted of numerous events throughout the week giving these scientists the opportunity to not only create a community amongst themselves, but to also engage and build relationships with senior scientists. In order to support the Early Career Scientists Program, IGAC sought funding from international, regional and local organizations to provide Travel Grants to the conference based on an assessment of both need and merit. This conference summary reports on outcomes of the 2016 IGAC Science Conference and the Early Career Program, which included early career travel grants funded by this DOE grant.« less

Development of a Composite Measure of State-Level Malpractice Environment

PubMed Central

Chung, Jeanette W; Sohn, Min-Woong; Merkow, Ryan P; Oh, Elissa H; Minami, Christina; Black, Bernard S; Bilimoria, Karl Y

2014-01-01

Objective To develop a composite measure of state-level malpractice environment. Data Sources Public use data from the National Practitioner Data Bank, Medical Liability Monitor, the National Conference of State Legislatures, and the American Bar Association. Study Design Principal component analysis of state-level indicators (paid claims rate, malpractice premiums, lawyers per capita, average award size, and malpractice laws), with indirect validation of the composite using receiver-operating characteristic curves to determine how accurately the composite could identify states with high-tort activity and costs. Principal Findings A single composite accounted for over 73 percent of total variance in the seven indicators and demonstrated reasonable criterion validity. Conclusion An empirical composite measure of state-level malpractice risk may offer advantages over single indicators in measuring overall risk and may facilitate cross-state comparisons of malpractice environments. PMID:24117397

44th Annual Anomalous Absorption Conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beg, Farhat

Conference Grant Report July 14, 2015 Submitted to the U. S. Department of Energy Attn: Dr. Sean Finnegan By the University of California, San Diego 9500 Gilman Drive La Jolla, California 92093 On behalf of the 44th Annual Anomalous Absorption Conference 8-13 June 2014, in Estes Park, Colorado Support Requested: $10,100 Amount expended: $3,216.14 Performance Period: 1 March 20 14 to 28 February 20 15 Principal Investigator Dr. Farhat Beg Center for Energy Research University of California, San Diego 9500 Gilman Drive La Jolla, California 92093-0417 858-822-1266 (telephone) 858-534-4543 (fax) fbeg@ucsd.edu Administrative Point of Contact: Brandi Pate, 858-534-0851, blpate®ucsd.edu I.more » Background The forty-fourth Anomalous Absorption Conference was held in Estes Park, Colorado from June 5-8, 2014 (aac2014.ucsd.edu). The first Anomalous Absorption Conference was held in 1971 to assemble experts in the poorly understood area of laser-plasma absorption. The goal of that conference was to address the anomalously large laser absorption seen in plasma experiments with respect to the laser absorption predicted by linear plasma theory. Great progress in this research area has been made in the decades since that first meeting, due in part to the scientific interactions that have occurred annually at this conference. Specifically, this includes the development of nonlinear laser-plasma theory and the simulation of laser interactions with plasmas. Each summer since that first meeting, this week-long conference has been held at unique locations in North America as a scientific forum for intense scientific exchanges relevant to the interaction of laser radiation with plasmas. Responsibility for organizing the conference has traditional rotated each year between the major Inertial Confinement Fusion (ICF) laboratories and universities including LANL, LLNL, LLE, UCLA UC Davis and NRL. As the conference has matured over the past four decades, its technical footprint has expanded beyond ICF-related laser-plasma interactions to encompass closely related technical areas including laser particle acceleration, high-intensity laser effects, short­ pulse laser interactions, PIC and Vlasov/rad-hydro modeling, inertial and magnetic fusion plasmas, advanced plasma diagnostics, alternate ignition schemes, EOS/transport/opacity, and this year, x­ ray free-electron lasers and their applications. The conference continues to be a showcase for the presentation and discussion of the latest developments in these areas. II. Meeting Report The conference was extremely successful with more than one hundred participants. There were ninety-nine (99) abstracts submitted. There were forty-four (44) presentations including eleven (11) invited talks. The following topics were covered: a) Radiation Hydrodynamics b) Implosion Plasma Kinetic Effects c) Alternate Ignition Schemes d) Astrophysical Phenomena e) Opacity/Transport/EOS f) High Power Lasers and Facilities g) High-Intensity Laser-Matter Interactions h) Hydrodynamics and Hydro-instabilities i) Hot Dense Plasma Atomic Processes j) High Energy Density Physics k) Laser Particle Acceleration Physics l) Advanced Plasma Diagnostics m) Advanced light sources and applications Despite significant advertising, there were two students who applied for the travel grants: Charlie Jarrott and Joohwan Kim. The total funds expended were $3,216.14.« less

Prescription omega-3 fatty acid products containing highly purified eicosapentaenoic acid (EPA).

PubMed

Brinton, Eliot A; Mason, R Preston

2017-01-31

The omega-3 fatty acid eicosapentaenoic acid (EPA) has multiple actions potentially conferring cardiovascular benefit, including lowering serum triglyceride (TG) and non-high-density lipoprotein cholesterol (non-HDL-C) levels and potentially reducing key steps in atherogenesis. Dietary supplements are a common source of omega-3 fatty acids in the US, but virtually all contain docosahexaenoic acid (DHA) in addition to EPA, and lipid effects differ between DHA and EPA. Contrary to popular belief, no over-the-counter omega-3 products are available in the US, only prescription products and dietary supplements. Among the US prescription omega-3 products, only one contains EPA exclusively (Vascepa); another closely related prescription omega-3 product also contains highly purified EPA, but is approved only in Japan and is provided in different capsule sizes. These high-purity EPA products do not raise low-density lipoprotein cholesterol (LDL-C) levels, even in patients with TG levels >500 mg/dL, in contrast to the increase in LDL-C levels with prescription omega-3 products that also contain DHA. The Japanese prescription EPA product was shown to significantly reduce major coronary events in hypercholesterolemic patients when added to statin therapy in the Japan EPA Lipid Intervention Study (JELIS). The effects of Vascepa on cardiovascular outcomes are being investigated in statin-treated patients with high TG levels in the Reduction of Cardiovascular Events With EPA-Intervention Trial (REDUCE-IT).

Flight is the key to postprandial blood glucose balance in the fruit bats Eonycteris spelaea and Cynopterus sphinx.

PubMed

Peng, Xingwen; He, Xiangyang; Liu, Qi; Sun, Yunxiao; Liu, Hui; Zhang, Qin; Liang, Jie; Peng, Zhen; Liu, Zhixiao; Zhang, Libiao

2017-11-01

Excessive sugar consumption could lead to high blood glucose levels that are harmful to mammalian health and life. Despite consuming large amounts of sugar-rich food, fruit bats have a longer lifespan, raising the question of how these bats overcome potential hyperglycemia. We investigated the change of blood glucose level in nectar-feeding bats ( Eonycteris spelaea ) and fruit-eating bats ( Cynopterus sphinx ) via adjusting their sugar intake and time of flight. We found that the maximum blood glucose level of C. sphinx was higher than 24 mmol/L that is considered to be pathological in other mammals. After C. sphinx bats spent approximately 75% of their time to fly, their blood glucose levels dropped markedly, and the blood glucose of E. spelaea fell to the fast levels after they spent 70% time of fly. Thus, the level of blood glucose elevated with the quantity of sugar intake but declined with the time of flight. Our results indicate that high-intensive flight is a key regulator for blood glucose homeostasis during foraging. High-intensive flight may confer benefits to the fruit bats in foraging success and behavioral interactions and increases the efficiency of pollen and seed disposal mediated by bats.

Vancouver AIDS conference: special report. A verdict on the conference: sadly, not one world or one hope.

PubMed

Whiteside, A

1996-01-01

Although the theme of the 11th International Conference on AIDS held in Vancouver during July 7-12, 1996, was "One World, One Hope," developed and developing countries have HIV/AIDS epidemics of different magnitudes, different levels of resources with which to combat the problems, and dissimilar objectives. The latest data released at the conference report an estimated 21.8 million people to be currently living with HIV/AIDS, the vast majority of whom live in developing countries. 84% of the estimated 7.7 million AIDS cases which have occurred since the beginning of the pandemic were in Africa or Asia; only 9% were in Europe and the US. The greatest burden of disease is and will be therefore experienced in the developing world which, relative to the developed world, has extremely limited resources. The epidemic continues to spread throughout much of the developing world, while levels of HIV infection in the developed world are largely remaining constant, with the center seemingly moving more into marginalized groups such as the homeless, drug users, and other groups. A whole range of new drugs will soon be available to treat HIV/AIDS among those who can afford them. It is possible that AIDS may simply become manageable as a chronic illness in the west. Such drugs, however, will be prohibitively expensive for almost all people infected with HIV. Moreover, the side effects of these new drugs remain to be seen, and it is possible that individuals will develop resistance to the treatment. The author laments the lack of papers at the conference analyzing the impact of the epidemic and hopes to see more representation and consideration of the developing world at the next conference, to be held in Geneva in 1998.

High-Level Primary Clarithromycin Resistance of Helicobacter pylori in Algiers, Algeria: A Prospective Multicenter Molecular Study.

PubMed

Djennane-Hadibi, Fazia; Bachtarzi, Mohamed; Layaida, Karim; Ali Arous, Nassima; Nakmouche, Mhamed; Saadi, Berkane; Tazir, Mohamed; Ramdani-Bouguessa, Nadjia; Burucoa, Christophe

2016-04-01

Knowledge of local antibiotic resistance is crucial to adaptation for the choice of the optimal first-line treatment for Helicobacter pylori infection. Clarithromycin is a key component of the standard triple therapy largely used worldwide and, more particularly, in Algeria. Clarithromycin resistance is the main risk factor for treatment failure. The aim of this study was to evaluate, for the first time in Algeria, the prevalence of the primary resistance of H. pylori to clarithromycin. We conducted a prospective study (2008-2014) that included 195 Algerian patients referred for gastroduodenal endoscopy to two University Hospitals, one General Hospital, and several private gastroenterologists in Algiers (Algeria). One gastric biopsy was collected for the molecular detection of H. pylori and the mutations in 23S rRNA genes that confer resistance to clarithromycin with a quadruplex real-time PCR using Scorpion primers. The Scorpion PCR detected H. pylori DNA in 91 biopsies (47%). A mutation conferring resistance to clarithromycin was detected in 32 of the 91 positive patients (35%) and in 29 of the 88 positive patients never previously treated for an H. pylori infection (33%). The prevalence of primary resistance of H. pylori to clarithromycin was 33% in the Algerian population being studied. The high level of primary clarithromycin resistance in the H. pylori strains infecting the Algerian population that we report leads us to recommend the abandonment of the standard clarithromycin-based triple therapy as a first-line treatment in Algeria.

Voltage-sensitive sodium channel mutations S989P + V1016G in Aedes aegypti confer variable resistance to pyrethroids, DDT and oxadiazines.

PubMed

Smith, Letícia B; Kasai, Shinji; Scott, Jeffrey G

2018-03-01

Aedes aegypti is a vector of several important human pathogens. Control efforts rely primarily on pyrethroid insecticides for adult mosquito control, especially during disease outbreaks. A. aegypti has developed resistance nearly everywhere it occurs and insecticides are used. An important mechanism of resistance is due to mutations in the voltage-sensitive sodium channel (Vssc) gene. Two mutations, in particular, S989P + V1016G, commonly occur together in parts of Asia. We have created a strain (KDR:ROCK) that contains the Vssc mutations S989P + V1016G as the only mechanism of pyrethroid resistance within the genetic background of Rockefeller (ROCK), a susceptible lab strain. We created KDR:ROCK by crossing the pyrethroid-resistant strain Singapore with ROCK followed by four backcrosses with ROCK and Vssc S989P + V1016G genotype selections. We determined the levels of resistance conferred to 17 structurally diverse pyrethroids, the organochloride DDT, and oxadiazines (VSSC blockers) indoxacarb (proinsecticide) and DCJW (the active metabolite of indoxacarb). Levels of resistance to the pyrethroids were variable, ranging from 21- to 107-fold, but no clear pattern between resistance and chemical structure was observed. Resistance is inherited as an incompletely recessive trait. KDR:ROCK had a > 2000-fold resistance to DDT, 37.5-fold cross-resistance to indoxacarb and 13.4-fold cross-resistance to DCJW. Etofenprox (and DDT) should be avoided in areas where Vssc mutations S989P + V1016G exist at high frequencies. We found that pyrethroid structure cannot be used to predict the level of resistance conferred by kdr. These results provide useful information for resistance management and for better understanding pyrethroid interactions with VSSC. © 2017 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. © 2017 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Hypophosphatemia during continuous veno-venous hemofiltration is associated with mortality in critically ill patients with acute kidney injury.

PubMed

Yang, Yi; Zhang, Ping; Cui, Yu; Lang, Xia; Yuan, Jing; Jiang, Hua; Lei, Wen; Lv, Rong; Zhu, Yi; Lai, En; Chen, Jiang

2013-09-19

The primary aim of this study was to determine whether hypophosphatemia during continuous veno-venous hemofiltration (CVVH) is associated with the global outcome of critically ill patients with acute kidney injury (AKI). 760 patients diagnosed with AKI and had received CVVH therapy were retrospectively recruited. Death during the 28-day period and survival at 28 days after initiation of CVVH were used as endpoints. Demographic and clinical data including serum phosphorus levels were recorded along with clinical outcome. Hypophosphatemia was defined according to the colorimetric method as serum phosphorus levels < 0.81 mmol/L (2.5 mg/dL), and severe hypophosphatemia was defined as serum phosphorus levels < 0.32 mmol/L (1 mg/dL). The ratio of CVVH therapy days with hypophosphatemia over total CVVH therapy days was calculated to reflect the persistence of hypophosphatemia. The Cox proportional hazard survival model analysis indicated that the incidence of hypophosphatemia or even severe hypophosphatemia was not associated with 28-day mortality independently (p = 0.700). Further analysis with the sub-cohort of patients who had developed hypophosphatemia during the CVVH therapy period indicated that the mean ratio of CVVH therapy days with hypophosphatemia over total CVVH therapy days was 0.58, and the ratio independently associated with the global outcome. Compared with the patients with low ratio (< 0.58), those with high ratio (≥ 0.58) conferred a 1.451-fold increase in 28-day mortality rate (95% CI 1.103-1.910, p = 0.008). Hypophosphatemia during CVVH associated with the global clinical outcome of critically ill patients with AKI. The ratio of CVVH therapy days with hypophosphatemia over total CVVH therapy days was independently associated with the 28-day mortality, and high ratio conferred higher mortality rate.

Insertion of transposon in the vicinity of SSK2 confers enhanced tolerance to furfural in Saccharomyces cerevisiae.

PubMed

Kim, Hyun-Soo; Kim, Na-Rae; Kim, Wankee; Choi, Wonja

2012-07-01

Furfural is one of the major inhibitors generated during sugar production from cellulosic materials and, as an aldehyde, inhibits various cellular activities of microorganisms used, leading to prolonged lag time during ethanologenic fermentation. Since Saccharomyces cerevisiae strains tolerant to furfural are of great economic benefit in producing bioethanol, much effort to obtain more efficient strains continues to be made. In this study, we examined the furfural tolerance of transposon mutant strains (Tn 1-5) with enhanced ethanol tolerance and found that one of them (Tn 2), in which SSK2 is downregulated at the transcriptional level, displayed improved furfural tolerance. Such phenotype was abolished by complementation of the entire open reading frame of SSK2, which encodes a mitogen-activated protein (MAP) kinase kinase kinase of the high osmolarity glycerol (HOG) signaling pathway, suggesting an inhibitory effect of SSK2 in coping with furfural stress. Tn 2 showed a significant decrease in the intracellular level of reactive oxygen species (ROS) and early and high activation of Hog1p, a MAP kinase integral to the HOG pathway in response to furfural. The transcriptional levels of CTT1 and GLR1, two of known Hog1p downstream target genes whose protein products are involved in reducing ROS, were increased by 43 % and 56 % respectively compared with a control strain, probably resulting in the ROS decrease. Tn 2 also showed a shortened lag time during fermentation in the presence of furfural, resulting from efficient conversion of furfural to non-toxic (or less toxic) furfuryl alcohol. Taken together, the enhanced furfural tolerance of Tn 2 is suggested to be conferred by the combined effect of an early event of less ROS accumulation and a late event of efficient detoxification of furfural.

Genetic characterization of an extended-spectrum AmpC cephalosporinase with hydrolysing activity against fourth-generation cephalosporins in a clinical isolate of Enterobacter aerogenes selected in vivo.

PubMed

Rodríguez-Martínez, Jose M; Fernández-Echauri, Pedro; Fernández-Cuenca, Felipe; Diaz de Alba, Paula; Briales, Alejandra; Pascual, Alvaro

2012-01-01

Extended-spectrum AmpC cephalosporinases (ESACs) have been reported in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii. Here, we characterize a new AmpC variant presenting a broadened substrate activity towards fourth-generation cephalosporins, selected in vivo following cefepime treatment for Enterobacter aerogenes. Two consecutive clonally related isolates of E. aerogenes were evaluated. Screening for ESAC production was performed using plates containing 200 mg/L cloxacillin. MICs were determined by microdilution (CLSI guidelines). bla(AmpC) genes were cloned into a pCR-Blunt II-TOPO vector and expressed in Escherichia coli. The ampC genes were cloned into vector pGEX-6P-1 for protein purification. Isolate Ea595 was resistant to two fourth-generation cephalosporins, cefepime and cefpirome; using plates containing cloxacillin, susceptibility to ceftazidime and cefepime was restored, suggesting overproduction of the ESAC β-lactamase. Sequencing identified a new AmpC β-lactamase variant presenting one amino acid substitution, Val291Gly, inside the H-10 helix. Recombinant plasmids harbouring this ESAC β-lactamase conferred a broadened resistance profile to cefepime and cefpirome, with resistance levels increasing from 16- to 32-fold in E. coli. AmpC-Ea595 hydrolysed ceftazidime, cefepime and cefpirome at high levels, presenting a lower K(m) and enabling us to classify the enzyme as an ESAC. Homology modelling suggested that the size of the active site could have increased. We characterized an ESAC β-lactamase selected in vivo and conferring a high level of resistance to fourth-generation cephalosporins in E. aerogenes. The broadened spectrum was caused by a new modification to the H-10 helix, which modified the active site.

PREFACE: 5th Workshop of Young Researchers in Astronomy & Astrophysics

NASA Astrophysics Data System (ADS)

Forgács-Dajka, Emese; Plachy, Emese; Molnár, László

2010-04-01

The 5th Workshop of Young Researchers in Astronomy and Astrophysics was held on 2-4 September 2009 at the Eötvös University in Budapest, Hungary. This meeting fits into a conference series which can already be considered a tradition where the younger generation has the opportunity to present their work. The event was also a great opportunity for senior astronomers and physicists to form new connections with the next generation of researchers. The selection of invited speakers concentrated on the researchers currently most active in the field, mostly on a post-doctoral/tenure/fresh faculty position level. A number of senior experts and PhD students were also invited. As the conference focused on people rather than a specific field, various topics from theoretical physics to planetology were covered in three days. The programme was divided into six sections: Physics of the Sun and the Solar System Gravity and high-energy physics Galactic and extragalactic astronomy, cosmology Celestial mechanics and exoplanets Infrared astronomy and young stars Variable stars We had the pleasure of welcoming 10 invited review talks from senior researchers and 42 contributed talks and a poster from the younger generation. Participants also enjoyed the hospitality of the pub Pál at the Pálvölgyi-cave after giving, hearing and disputing countless talks. Brave souls even descended to the unbuilt, adventurous Mátyásvölgyi-cave. Memories of the conference were shadowed though. Péter Csizmadia, one of our participants and three other climbers attempted a first ever ascent to the Ren Zhong Feng peak in Sichuan, China, but they never returned from the mountains. Péter departed to China shortly after the conference, with best wishes from participants and friends. We dedicate this volume to his memory. The organisers thankthe Physics Doctoral School of Eötvös University for its hospitality. The workshop was supported by the Mecenatúra and Polányi Mihály Programmes of the National Office for Research and Technology (NKTH) and the Ministry of Education and Culture (OKM) of Hungary. Emese Forgács-Dajka, Emese Plachy and László Molnár Conference photograph Conference photograph

35th International Conference of High Energy Physics

NASA Astrophysics Data System (ADS)

The French particle physics community is particularly proud to have been selected to host the 35th ICHEP conference in 2010 in Paris. This conference is the focal point of all our field since more than fifty years and is the reference event where all important results in particle physics cosmology and astroparticles are presented and discussed. This alone suffices to make this event very important. But in 2010, a coincidence of exceptional events will make this conference even more attractive! What is then so special about ICHEP 2010 conference? It will be the first ICHEP conference where physics results obtained at the LHC will be presented! New results about the elusive Higgs boson, or signals of physics beyond the standard model might therefore be announced at this conference! Major discoveries in other domains such as gravitational waves, neutrino telescopes, neutrino oscillations, dark matter or in the flavour sector are also possible, just to name a few. In addition , 2010 will be an important date to shape up the future of our field. Several major projects will present the status of their Conceptual or Engineering Design Reports during the conference. The International Linear Collider (ILC) Global Design Effort team will present the report corresponding to the end of their Technical Design Phase 1. The Compact Linear Collider (CLIC) will also report on its Conceptual Design Report. Other major projects such as Super B factories will also be presented. These reports together with LHC physics results will form the basis for key political decisions needed to be taken in the years to come. In summary, there can be no doubt that Paris is the place to be in summer 2010 for anyone interested in High Energy Physics and we will make every effort to make your stay as interesting and enjoyable as possible.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lock, Reinier

This conference's high turnout and buoyant mood was a tribute to the progress that the Corporate Council on Africa, and the constituencies represented at the conference, have made in focusing on Africa's real development challenges and in persuading U.S. corporations and institutions to do so. (author)

D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile

PubMed Central

Valleix, Sophie; Verona, Guglielmo; Jourde-Chiche, Noémie; Nédelec, Brigitte; Mangione, P. Patrizia; Bridoux, Frank; Mangé, Alain; Dogan, Ahmet; Goujon, Jean-Michel; Lhomme, Marie; Dauteuille, Carolane; Chabert, Michèle; Porcari, Riccardo; Waudby, Christopher A.; Relini, Annalisa; Talmud, Philippa J.; Kovrov, Oleg; Olivecrona, Gunilla; Stoppini, Monica; Christodoulou, John; Hawkins, Philip N.; Grateau, Gilles; Delpech, Marc; Kontush, Anatol; Gillmore, Julian D.; Kalopissis, Athina D.; Bellotti, Vittorio

2016-01-01

Apolipoprotein C-III deficiency provides cardiovascular protection, but apolipoprotein C-III is not known to be associated with human amyloidosis. Here we report a form of amyloidosis characterized by renal insufficiency caused by a new apolipoprotein C-III variant, D25V. Despite their uremic state, the D25V-carriers exhibit low triglyceride (TG) and apolipoprotein C-III levels, and low very-low-density lipoprotein (VLDL)/high high-density lipoprotein (HDL) profile. Amyloid fibrils comprise the D25V-variant only, showing that wild-type apolipoprotein C-III does not contribute to amyloid deposition in vivo. The mutation profoundly impacts helical structure stability of D25V-variant, which is remarkably fibrillogenic under physiological conditions in vitro producing typical amyloid fibrils in its lipid-free form. D25V apolipoprotein C-III is a new human amyloidogenic protein and the first conferring cardioprotection even in the unfavourable context of renal failure, extending the evidence for an important cardiovascular protective role of apolipoprotein C-III deficiency. Thus, fibrate therapy, which reduces hepatic APOC3 transcription, may delay amyloid deposition in affected patients. PMID:26790392

MEETING EDUCATIONAL NEEDS FOR POST-HIGH SCHOOL AGE YOUTH AND ADULTS IN ALABAMA, A REPORT OF CONFERENCES HELD ON VOCATIONAL, TECHNICAL, AND JUNIOR COLLEGE EDUCATION (AUBURN UNIVERSITY, 1964).

ERIC Educational Resources Information Center

Auburn Univ., AL. School of Education.

SPEECHES GIVEN AT THREE MEETINGS ARE INCLUDED--(1) A FACULTY MEETING OF THE SCHOOL OF EDUCATION, AUBURN UNIVERSITY (JANUARY 31, 1964), (2) THE ANNUAL SPRING CONFERENCE OF THE ALABAMA ASSOCIATION OF SCHOOL ADMINISTRATORS (APRIL 26-27, 1964), AND (3) A CONFERENCE SPONSORED BY THE SCHOOL OF EDUCATION AUBURN UNIVERSITY (JUNE 22-23, 1964). THE SPEECHES…

Manufacturing and operational issues with lead-acid batteries

NASA Astrophysics Data System (ADS)

Rand, D. A. J.; Boden, D. P.; Lakshmi, C. S.; Nelson, R. F.; Prengaman, R. D.

An expert panel replies to questions on lead-acid technology and performance asked by delegates to the Ninth Asian Battery Conference. The subjects are as follows. Grid alloys: effects of calcium and tin levels on microstructure, corrosion, mechanical and electrochemical properties; effect of alloy-fabrication process on mechanical strength and corrosion resistance; low dross-make during casting of lead-calcium-tin alloys; future of book-mould casting; effect of increasing levels of silver; stability of continuously processed grids at high temperature. Negative-plate expanders: function of lignosulfonates and barium sulfate; benefits of pre-blended expanders; optimum expander formulations. Valve-regulated batteries: effect of oxygen cycle; optimum methods for float charging; charging and deep-cycle lifetimes; reliability testing.

COST Action MP0806 'Particles in Turbulence': International Conference on Fundamentals, Experiments, Numeric and Applications

NASA Astrophysics Data System (ADS)

Abel, Markus; Bodenschatz, Eberhard; Toschi, Federico

2011-12-01

Turbulent flows are ubiquitous in nature and technology. Turbulent flows govern the transport of particulate matter in nature. For example, in atmospheric flows turbulence impacts the dynamics of aerosols, droplets, spores and of the living world by either chemo-attractant transport or transport of the insects themselves. In marine flows examples include the bubble dynamics that governs the uptake of oxygen and carbon dioxide at the ocean air interface, or the impact of turbulence on the life of phyto- and zoo-plankton, or the spread of pollutants in the oceans and estuaries. Turbulence is equally important for technology from process engineering in chemical and pharmaceutical industries to energy transport and energy generation. The COST Action MP0806 'Particles in Turbulence' has as the primary objective the support of the fundamental research on the statistical properties of particle transport in turbulent flows. The Action provides excellent opportunities for the exchange of ideas by bringing together scientists from different areas of research and applications, or different views on the problem. The COST Action MP0806 organizes several events annually. The conference held at the University of Potsdam from 16 to 18 March 2011 was the main meeting of the Action in 2011. In total 87 researchers from 18 countries (of which 12 were European) met and presented their work, discussed new ideas on theoretical, numerical and experimental approaches, as well as on applications to various scientific domains. The conference attracted also a number of participants from outside the COST Action. The scientific presentations focused on inertial and finite-size particles, particle collisions, as well as advection and reaction in simple and complex flow geometries. Very interesting results were presented at the forefront of the field: the increasing computational power combined with novel numerical techniques now allows for the first time simulation of the dynamics of finites size particles, of bubbles, or of the large scale dynamics of convective clouds. Similarly the technical evolution provided major leaps on the experimental side. High-speed cameras, refined turbulence setups, specially prepared particles, etc allow high-precision measurements of larger span in space- and time-scales and quantitative comparison with simulations and theoretical models. The formation of rain, one of the key ingredients of climate models, still attracts considerable attention and this topic motivated many studies presented during the conference. Finally, new theoretical developments are emerging further demonstrating the vitality of this research field. In total, 83 contributed talks were presented (60 presentations have been made available for download from the COST Action website, http://mp0806.cineca.it), 16 keynote speakers gave plenary talks, while 3 specifically invited speakers provided overviews on important application areas: aerosol control in nuclear safety applications ('Postulated Nuclear Accidents: Evaluating Radioactive Releases with Special Emphasis on Particulate' by Martin Kissane), formation of rain in warm clouds ('Growth of cloud droplets and raindrops in turbulent clouds' by by Wojciech Grabowski) and evolution of biological aggregates in marine environments ('Aggregation and fragmentation of marine aggregates in random flows' by Ulrike Feudel). The scientific level of all presentations was very high and participants really enjoyed the conference despite (or maybe thanks to) the very intense program. Motivated by the very rapid pace of progress in the field, we have scheduled another conference for next year to be held at Lorentz Center in Leiden (The Netherlands). We expect that this conference shall be the start of a conference series on 'Particles in Turbulence'. The conference would have neither been possible without the financial support of the COST Office, nor without the contagious enthusiasm of the many participants. We would also like to thank the students from Potsdam University for their exquisite help. We are very thankful to Anita Peeters for her unwavering support and help in the organization of this particular event, as well as, for the efforts ensuring the smooth running of the COST Action 'Particles in turbulence'. Markus Abel, Eberhard Bodenschatz, Federico Toschi The PDF files of the conference program and conference poster are attached.

Effect of Multidisciplinary Cancer Conference on Treatment Plan for Patients With Primary Rectal Cancer.

PubMed

Snelgrove, Ryan C; Subendran, Jhananiee; Jhaveri, Kartik; Thipphavong, Seng; Cummings, Bernard; Brierley, James; Kirsch, Richard; Kennedy, Erin D

2015-07-01

Although multidisciplinary cancer conferences have been reported to lead to improved patient outcomes, few studies have reported results of these for rectal cancer. The purpose of this work was to assess the quality of multidisciplinary cancer conferences, the effect of the conference on the initial treatment plan, compliance with the conference treatment recommendations, and clinical outcomes for rectal cancer. This was a prospective, longitudinal study. The study was conducted at a tertiary care academic hospital. Patients with primary rectal cancer were included in this study. The intervention was a rectal cancer-specific multidisciplinary cancer conference. The quality of the multidisciplinary cancer conference was assessed using the Cancer Care Ontario Multidisciplinary Cancer Conference standards score. A change in treatment plan was defined as a change from the initial treatment plan selected by the treating physician to an alternate treatment plan recommended at the conference. Twenty-five multidisciplinary cancer conferences were conducted over a 10-month study period. The Cancer Care Ontario Multidisciplinary Cancer Conference standards score was 7 (from a maximum score of 9). Forty-two patients with primary rectal cancer were presented, and there was a 29% (12/42) change in the initial treatment plan. A total of 42% (5/12) of these changes were attributed to reinterpretation of the MRI findings. There was 100% compliance with the conference treatment recommendations. The circumferential resection margin was positive in 5.5% (2/36). Selection bias may have led to an overestimate of effect, and there is no control group for comparison of clinical outcomes. A high-quality rectal cancer-specific multidisciplinary cancer conference led to a 29% change in the treatment plan for patients with primary rectal cancer, with almost half of these changes attributed to reinterpretation of the magnetic resonance images.

Directed combinatorial mutagenesis of Escherichia coli for complex phenotype engineering

DOE Office of Scientific and Technical Information (OSTI.GOV)

Liu, Rongming; Liang, Liya; Garst, Andrew D.

Strain engineering for industrial production requires a targeted improvement of multiple complex traits, which range from pathway flux to tolerance to mixed sugar utilization. Here, we report the use of an iterative CRISPR EnAbled Trackable genome Engineering (iCREATE) method to engineer rapid glucose and xylose co-consumption and tolerance to hydrolysate inhibitors in E. coli. Deep mutagenesis libraries were rationally designed, constructed, and screened to target ~40,000 mutations across 30 genes. These libraries included global and high-level regulators that regulate global gene expression, transcription factors that play important roles in genome-level transcription, enzymes that function in the sugar transport system, NAD(P)Hmore » metabolism, and the aldehyde reduction system. Specific mutants that conferred increased growth in mixed sugars and hydrolysate tolerance conditions were isolated, confirmed, and evaluated for changes in genome-wide expression levels. As a result, we tested the strain with positive combinatorial mutations for 3-hydroxypropionic acid (3HP) production under high furfural and high acetate hydrolysate fermentation, which demonstrated a 7- and 8-fold increase in 3HP productivity relative to the parent strain, respectively.« less

Directed combinatorial mutagenesis of Escherichia coli for complex phenotype engineering

DOE PAGES

Liu, Rongming; Liang, Liya; Garst, Andrew D.; ...

2018-03-29

Strain engineering for industrial production requires a targeted improvement of multiple complex traits, which range from pathway flux to tolerance to mixed sugar utilization. Here, we report the use of an iterative CRISPR EnAbled Trackable genome Engineering (iCREATE) method to engineer rapid glucose and xylose co-consumption and tolerance to hydrolysate inhibitors in E. coli. Deep mutagenesis libraries were rationally designed, constructed, and screened to target ~40,000 mutations across 30 genes. These libraries included global and high-level regulators that regulate global gene expression, transcription factors that play important roles in genome-level transcription, enzymes that function in the sugar transport system, NAD(P)Hmore » metabolism, and the aldehyde reduction system. Specific mutants that conferred increased growth in mixed sugars and hydrolysate tolerance conditions were isolated, confirmed, and evaluated for changes in genome-wide expression levels. As a result, we tested the strain with positive combinatorial mutations for 3-hydroxypropionic acid (3HP) production under high furfural and high acetate hydrolysate fermentation, which demonstrated a 7- and 8-fold increase in 3HP productivity relative to the parent strain, respectively.« less

Identifying patients with severe sepsis using administrative claims: patient-level validation of the angus implementation of the international consensus conference definition of severe sepsis.

PubMed

Iwashyna, Theodore J; Odden, Andrew; Rohde, Jeffrey; Bonham, Catherine; Kuhn, Latoya; Malani, Preeti; Chen, Lena; Flanders, Scott

2014-06-01

Severe sepsis is a common and costly problem. Although consistently defined clinically by consensus conference since 1991, there have been several different implementations of the severe sepsis definition using ICD-9-CM codes for research. We conducted a single center, patient-level validation of 1 common implementation of the severe sepsis definition, the so-called "Angus" implementation. Administrative claims for all hospitalizations for patients initially admitted to general medical services from an academic medical center in 2009-2010 were reviewed. On the basis of ICD-9-CM codes, hospitalizations were sampled for review by 3 internal medicine-trained hospitalists. Chart reviews were conducted with a structured instrument, and the gold standard was the hospitalists' summary clinical judgment on whether the patient had severe sepsis. Three thousand one hundred forty-six (13.5%) hospitalizations met ICD-9-CM criteria for severe sepsis by the Angus implementation (Angus-positive) and 20,142 (86.5%) were Angus-negative. Chart reviews were performed for 92 randomly selected Angus-positive and 19 randomly-selected Angus-negative hospitalizations. Reviewers had a κ of 0.70. The Angus implementation's positive predictive value was 70.7% [95% confidence interval (CI): 51.2%, 90.5%]. The negative predictive value was 91.5% (95% CI: 79.0%, 100%). The sensitivity was 50.4% (95% CI: 14.8%, 85.7%). Specificity was 96.3% (95% CI: 92.4%, 100%). Two alternative ICD-9-CM implementations had high positive predictive values but sensitivities of <20%. The Angus implementation of the international consensus conference definition of severe sepsis offers a reasonable but imperfect approach to identifying patients with severe sepsis when compared with a gold standard of structured review of the medical chart by trained hospitalists.

Effects of a mobility monitoring system on the cost of care in relation to reimbursement at Swiss nursing homes: learnings from a randomized controlled trial.

PubMed

Stark, Mario; Tietz, Rigo; Gattinger, Heidrun; Hantikainen, Virpi; Ott, Stefan

2017-12-01

Nursing homes in Switzerland are under pressure to efficiently coordinate staff activities to cover their personnel costs under the care financing system. In this study, the use of a mobility monitoring system accompanied with case conferences was investigated in order to improve sleep quality and estimate the cost benefit of this intervention. In an open two-phase randomized controlled trial at three nursing homes, residents with cognitive impairment were randomly assigned to an intervention group and a control group. In the intervention group, a 10-week period of intensive use of the monitoring system and case conferences led by an advanced nurse practitioner (Phase I) was followed by 3 months of reduced use of the monitoring system and case conferences led by an internal registered nurse (Phase II). In the control group, the monitoring system was only used for data acquisition. Nurses reported the activities with a specifically developed tool. Based on the recorded activities, the cost of care was calculated. The correlating reimbursement per patient was calculated from the care levels in the Swiss reimbursement system. Data from 44 residents was included in the analysis with a linear mixed model. Although analysis revealed no statistically significant effects, results indicate that the use of a monitoring system can guide nurses in organizing their tasks to increase effectiveness. Information systems such as the mobility monitor can help to identify single outliers that do not correspond with the overall situation. In the health care system, problematic individual cases can account for a disproportionally high cost levels. It was shown that information systems can have a significant economic impact in the long run. The study is registered at the German Clinical Trials Register under the Nr. DRKS00006829 .

Herbicide resistance-endowing ACCase gene mutations in hexaploid wild oat (Avena fatua): insights into resistance evolution in a hexaploid species

PubMed Central

Yu, Q; Ahmad-Hamdani, M S; Han, H; Christoffers, M J; Powles, S B

2013-01-01

Many herbicide-resistant weed species are polyploids, but far too little about the evolution of resistance mutations in polyploids is understood. Hexaploid wild oat (Avena fatua) is a global crop weed and many populations have evolved herbicide resistance. We studied plastidic acetyl-coenzyme A carboxylase (ACCase)-inhibiting herbicide resistance in hexaploid wild oat and revealed that resistant individuals can express one, two or three different plastidic ACCase gene resistance mutations (Ile-1781-Leu, Asp-2078-Gly and Cys-2088-Arg). Using ACCase resistance mutations as molecular markers, combined with genetic, molecular and biochemical approaches, we found in individual resistant wild-oat plants that (1) up to three unlinked ACCase gene loci assort independently following Mendelian laws for disomic inheritance, (2) all three of these homoeologous ACCase genes were transcribed, with each able to carry its own mutation and (3) in a hexaploid background, each individual ACCase resistance mutation confers relatively low-level herbicide resistance, in contrast to high-level resistance conferred by the same mutations in unrelated diploid weed species of the Poaceae (grass) family. Low resistance conferred by individual ACCase resistance mutations is likely due to a dilution effect by susceptible ACCase expressed by homoeologs in hexaploid wild oat and/or differential expression of homoeologous ACCase gene copies. Thus, polyploidy in hexaploid wild oat may slow resistance evolution. Evidence of coexisting non-target-site resistance mechanisms among wild-oat populations was also revealed. In all, these results demonstrate that herbicide resistance and its evolution can be more complex in hexaploid wild oat than in unrelated diploid grass weeds. Our data provide a starting point for the daunting task of understanding resistance evolution in polyploids. PMID:23047200

Proceedings of the Annual Conference of the International Group for the Psychology of Mathematics Education (12th, Veszprem, Hungary, July 20-25, 1988), Volume 2.

ERIC Educational Resources Information Center

Borbas, Andrea, Ed.

The proceedings for the annual conference of the International Group for the Psychology of Mathematics Education (PME) include the following papers: "Intervention in a Mathematics Course at the College Level" (L. Gattuso & R. Lacasse); "The Education of Talented Children" (F. Genzwein); "The Development of a Model for Competence in Mathematical…

The Secretary's Conference on Educational Technology, 2000: Measuring Impacts and Shaping the Future. [Proceedings] (Alexandria, Virginia, September 11-12, 2000).

ERIC Educational Resources Information Center

Department of Education, Washington, DC.

This conference focused on the effective use of technology in schools by examining the following issues: (1) What value-added does technology bring to schools? (2) What does it take at the system level to enable learners, teachers, administrators, and communities to use technology effectively? (3) What assessment strategies and designs are…

Proceedings of the Annual Conference of the International Group for the Psychology of Mathematics Education (9th, Noordwijkerhout, The Netherlands, July 22-29, 1985), Volume 1: Individual Contributions.

ERIC Educational Resources Information Center

Streefland, Leen, Ed.

This proceedings of the annual conference of the International Group for the Psychology of Mathematics Education (PME) includes the following research papers: "Calculators in Primary Education" (van den Brink); "Microworlds and Van Hiele Levels" (Dreyfus, Thompson); "Dynamical Mazes and the Ob-Serving Computer" (Harmegnies, Lowenthal); "Iterative…

The Effect of Instructor Nonverbal Immediacy Behaviors and Feedback Sensitivity on Hispanic Students' Affective Learning Outcomes in Ninth-Grade Writing Conferences

ERIC Educational Resources Information Center

Martin, Laura; Mottet, Timothy P.

2011-01-01

The purpose of this study was to show how instructor use of nonverbal immediacy behaviors influence Hispanic students' affective learning in ninth-grade writing conferences, regardless of the level of feedback sensitivity provided. According to Kluger and DeNisi's (1996) feedback intervention theory, when feedback is direct and targeted on the…

LANGUAGE LEARNING--THE INTERMEDIATE PHASE. REPORTS OF THE WORKING COMMITTEES OF THE NORTHEAST CONFERENCE ON THE TEACHING OF FOREIGN LANGUAGES, 1963.

ERIC Educational Resources Information Center

BOTTIGLIA, WILLIAM F.

THESE REPORTS OF THE WORKING COMMITTEES OF THE 1963 NORTHEAST CONFERENCE ON THE TEACHING OF FOREIGN LANGUAGES ANALYZE PROBLEMS CONFRONTING LANGUAGE TEACHERS AS THEY PROGRESS FROM THE AUDIOLINGUAL ORIENTATION OF THE ELEMENTARY LEVELS TO THE INTERMEDIATE PHASE IN A CONTINUUM OF LANGUAGE STUDY. IN AN ATTEMPT TO DISCOVER WHETHER BILINGUALISM CAN BE…

Increased Tuberculosis Patient Mortality Associated with Mycobacterium tuberculosis Mutations Conferring Resistance to Second-Line Antituberculous Drugs

PubMed Central

Seifert, Marva; Garfein, Richard S.; Rodwell, Timothy C.

2017-01-01

ABSTRACT Rapid molecular diagnostics have great potential to limit the spread of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) (M/XDR-TB). These technologies detect mutations in the Mycobacterium tuberculosis genome that confer phenotypic drug resistance. However, there have been few data published regarding the relationships between the detected M. tuberculosis resistance mutations and M/XDR-TB treatment outcomes, limiting our current ability to exploit the full potential of molecular diagnostics. We analyzed clinical, microbiological, and sequencing data for 451 patients and their clinical isolates collected in a multinational, observational cohort study to determine if there was an association between M. tuberculosis resistance mutations and patient mortality. The presence of an rrs 1401G mutation was associated with significantly higher odds of patient mortality (adjusted odds ratio [OR] = 5.72; 95% confidence interval [CI], 1.65 to 19.84]) after adjusting for relevant patient clinical characteristics and all other resistance mutations. Further analysis of mutations, categorized by the associated resistance level, indicated that the detection of mutations associated with high-level fluoroquinolone (OR, 3.99 [95% CI, 1.10 to 14.40]) and kanamycin (OR, 5.47 [95% CI, 1.64 to 18.24]) resistance was also significantly associated with higher odds of patient mortality, even after accounting for clinical site, patient age, reported smoking history, body mass index (BMI), diabetes, HIV, and all other resistance mutations. Specific gyrA and rrs resistance mutations, associated with high-level resistance, were associated with patient mortality as identified in clinical M. tuberculosis isolates from a diverse M/XDR-TB patient population at three high-burden clinical sites. These results have important implications for the interpretation of molecular diagnostics, including identifying patients at increased risk for mortality during treatment. (This study has been registered at ClinicalTrials.gov under registration no. NCT02170441.) PMID:28404672

Increased Tuberculosis Patient Mortality Associated with Mycobacterium tuberculosis Mutations Conferring Resistance to Second-Line Antituberculous Drugs.

PubMed

Georghiou, Sophia B; Seifert, Marva; Catanzaro, Donald G; Garfein, Richard S; Rodwell, Timothy C

2017-06-01

Rapid molecular diagnostics have great potential to limit the spread of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) (M/XDR-TB). These technologies detect mutations in the Mycobacterium tuberculosis genome that confer phenotypic drug resistance. However, there have been few data published regarding the relationships between the detected M. tuberculosis resistance mutations and M/XDR-TB treatment outcomes, limiting our current ability to exploit the full potential of molecular diagnostics. We analyzed clinical, microbiological, and sequencing data for 451 patients and their clinical isolates collected in a multinational, observational cohort study to determine if there was an association between M. tuberculosis resistance mutations and patient mortality. The presence of an rrs 1401G mutation was associated with significantly higher odds of patient mortality (adjusted odds ratio [OR] = 5.72; 95% confidence interval [CI], 1.65 to 19.84]) after adjusting for relevant patient clinical characteristics and all other resistance mutations. Further analysis of mutations, categorized by the associated resistance level, indicated that the detection of mutations associated with high-level fluoroquinolone (OR, 3.99 [95% CI, 1.10 to 14.40]) and kanamycin (OR, 5.47 [95% CI, 1.64 to 18.24]) resistance was also significantly associated with higher odds of patient mortality, even after accounting for clinical site, patient age, reported smoking history, body mass index (BMI), diabetes, HIV, and all other resistance mutations. Specific gyrA and rrs resistance mutations, associated with high-level resistance, were associated with patient mortality as identified in clinical M. tuberculosis isolates from a diverse M/XDR-TB patient population at three high-burden clinical sites. These results have important implications for the interpretation of molecular diagnostics, including identifying patients at increased risk for mortality during treatment. (This study has been registered at ClinicalTrials.gov under registration no. NCT02170441.). Copyright © 2017 American Society for Microbiology.

Transparent and Open Discussion of Errors Does Not Increase Malpractice Risk in Trauma Patients

PubMed Central

Stewart, Ronald M.; Corneille, Michael G.; Johnston, Joe; Geoghegan, Kathy; Myers, John G.; Dent, Daniel L.; McFarland, Marilyn; Alley, Joshua; Pruitt, Basil A.; Cohn, Stephen M.

2006-01-01

Objective: We set out to determine if there is an increased medical malpractice lawsuit rate when trauma patient cases are presented at an open, multidisciplinary morbidity and mortality conference (M&M). Introduction: Patient safety proponents emphasize the importance of transparency with respect to medical errors. In contrast, the tort system focuses on blame and punishment, which encourages secrecy. Our question: Can the goals of the patient safety movement be met without placing care providers and healthcare institutions at unacceptably high malpractice risk? Methods: The trauma registry, a risk management database, along with the written minutes of the trauma morbidity and mortality conference (M&M) were used to determine the number and incidence of malpractice suits filed following full discussion at an open M&M conference at an academic level I trauma center. Results: A total of 20,749 trauma patients were admitted. A total of 412 patients were discussed at M&M conference and a total of seven lawsuits were filed. Six of the patients were not discussed at M&M prior to the lawsuit being filed. One patient was discussed at M&M prior to the lawsuit being filed. The incidence of lawsuit was calculated in three groups: all trauma patients, all trauma patients with complications, and all patients presented at trauma M&M conference. The ratio of lawsuits filed to patients admitted and incidence in the three groups is as follows: All Patients, 7 lawsuits/20,479 patients (4.25 lawsuits/100,000 patients/year); M&M Presentation, 1 lawsuit/421 patients (29.6 lawsuits/100,000 patients/year); All Trauma Complications, 7 lawsuits/6,225 patients (14 lawsuits/100,000 patients/year). Patients with a complication were more likely to sue (P < 0.01); otherwise, there were no statistical differences between groups. Conclusions: A transparent discussion of errors, complications, and deaths does not appear to lead to an increased risk of lawsuit. PMID:16632999

An educational conference in a general hospital.

PubMed

Caldwell, Gordon

2011-12-01

Western Sussex Hospitals National Health Service (NHS) Trust comprises the District General Hospitals of Worthing and Chichester. Both hospitals have successful postgraduate medical education centres, providing training for junior doctors and continuing professional development for senior doctors. Until now, there have been limited multi-professional teaching and learning activities available. The two hospitals have recently merged. The education executive felt that workplace learning had become undervalued since the implementation of Modernising Medical Careers in the UK. The executive wanted to provide a multi-professional conference on Workplace Learning, both to support the merger and to promote the value of workplace and multi-professional learning. The conference topic covering the 'how' of workplace learning was innovative. Many educational conferences concentrate on the organisation and evaluation of classroom learning, rather than on how learning can be facilitated in the workplace during ordinary working practice. It was also innovative to ensure that the presenters were representative of the multi-professional workforce. The presentations were limited to 8 minutes each to promote high-impact short presentations. The talks were recorded for publishing on the trust's intranet and the internet. A committed team in a district general hospital can provide a high-quality educational conference with wide appeal. Local health care professionals can produce short high-impact presentations. The use of modern information technology and audio-visual systems can make the presentations available to both local and worldwide audiences. © Blackwell Publishing Ltd 2011.

First UMTA and AoA National Conference on Transportation for the Elderly and Handicapped

DOT National Transportation Integrated Search

1985-05-01

The Conference was highly successful in detailing problems now encountered in : providing transportation services to the elderly and handicapped and in : recommending specific solutions to those problems. There was a strong focus on : realistic, prac...

NASA Public Affairs and NUANCE Lab News Conference at Reno-Stead Airport.

NASA Image and Video Library

2016-10-19

News Conference following the test of Unmanned Aircraft Systems Traffic Management (UTM) technical capability Level 2 (TCL2) at Reno-Stead Airport, Nevada. The UTM Reno Press Conference on Oct. 19, 2016. (Left to Right) Parimal Kopardekar, NASA Ames Senior Engineer for Air Transportation Systems gave an overview of UTM; Maril Mora, President / CEO of the Reno -Tahoe Airport Authority welcomes NASA and Partners; Tom Wilczek, Aerospace and Defence industry representative and Nevada Governor's Office of Economic Development; Mark Baker, Director of Business Development, Nevada Institute of Autonomous Systems; Manos Maragakis, Dean of the College of Engineering, University of Nevada, Reno.

Impact of metformin treatment and swimming exercise on visfatin levels in high-fat-induced obesity rats.

PubMed

Gao, Ya; Wang, Changjiang; Pan, Tianrong; Luo, Li

2014-02-01

Visfatin is a recently discovered adipocytokine that contributes to glucose and obesity-related conditions. Until now, its responses to the insulin-sensitizing agent metformin and to exercise are largely unknown. We aim to investigate the impact of metformin treatment and/or swimming exercise on serum visfatin and visfatin levels in subcutaneous adipose tissue (SAT), peri-renal adipose tissue (PAT) and skeletal muscle (SM) of high-fat-induced obesity rats. Sprague-Dawley rats were fed a normal diet or a high-fat diet for 16 weeks to develop obesity model. The high-fat-induced obesity model rats were then randomized to metformin (MET), swimming exercise (SWI), or adjunctive therapy of metformin and swimming exercise (MAS), besides high-fat obesity control group and a normal control group, all with 10 rats per group. Zoometric and glycemic parameters, lipid profile, and serum visfatin levels were assessed at baseline and after 6 weeks of therapy. Visfatin levels in SAT, PAT and SM were determined by Western Blot. Metformin and swimming exercise improved lipid profile, and increased insulin sensitivity and body weight reduction were observed. Both metformin and swimming exercise down-regulated visfatin levels in SAT and PAT, while the adjunctive therapy conferred greater benefits, but no changes of visfatin levels were observed in SM. Our results indicate that visfatin down-regulation in SAT and PAT may be one of the mechanisms by which metformin and swimming exercise inhibit obesity.

Identification of QTLs conferring resistance to downy mildew in legacy cultivars of lettuce

PubMed Central

Simko, Ivan; Atallah, Amy J.; Ochoa, Oswaldo E.; Antonise, Rudie; Galeano, Carlos H.; Truco, Maria Jose; Michelmore, Richard W.

2013-01-01

Many cultivars of lettuce (Lactuca sativa L.), the most popular leafy vegetable, are susceptible to downy mildew disease caused by Bremia lactucae. Cultivars Iceberg and Grand Rapids that were released in the 18th and 19th centuries, respectively, have high levels of quantitative resistance to downy mildew. We developed a population of recombinant inbred lines (RILs) originating from a cross between these two legacy cultivars, constructed a linkage map, and identified two QTLs for resistance on linkage groups 2 (qDM2.1) and 5 (qDM5.1) that determined resistance under field conditions in California and the Netherlands. The same QTLs determined delayed sporulation at the seedling stage in laboratory experiments. Alleles conferring elevated resistance at both QTLs originate from cultivar Iceberg. An additional QTL on linkage group 9 (qDM9.1) was detected through simultaneous analysis of all experiments with mixed-model approach. Alleles for elevated resistance at this locus originate from cultivar Grand Rapids. PMID:24096732

2011 Plant Lipids: Structure, Metabolism, & Function Gordon Research Conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Christopher Benning

2011-02-04

This is the second Gordon Research Conference on 'Plant Lipids: Structure, Metabolism & Function'. It covers current topics in lipid structure, metabolism and function in eukaryotic photosynthetic organisms including seed plants, algae, mosses and ferns. Work in photosynthetic bacteria is considered as well as it serves the understanding of specific aspects of lipid metabolism in plants. Breakthroughs are discussed in research on plant lipids as diverse as glycerolipids, sphingolipids, lipids of the cell surface, isoprenoids, fatty acids and their derivatives. The program covers nine concepts at the forefront of research under which afore mentioned plant lipid classes are discussed. Themore » goal is to integrate areas such as lipid signaling, basic lipid metabolism, membrane function, lipid analysis, and lipid engineering to achieve a high level of stimulating interaction among diverse researchers with interests in plant lipids. One Emphasis is on the dynamics and regulation of lipid metabolism during plant cell development and in response to environmental factors.« less

Practicing safe cell culture: applied process designs for minimizing virus contamination risk.

PubMed

Kiss, Robert D

2011-01-01

CONFERENCE PROCEEDING Proceedings of the PDA/FDA Adventitious Viruses in Biologics: Detection and Mitigation Strategies Workshop in Bethesda, MD, USA; December 1-3, 2010 Guest Editors: Arifa Khan (Bethesda, MD), Patricia Hughes (Bethesda, MD) and Michael Wiebe (San Francisco, CA) Genentech responded to a virus contamination in its biologics manufacturing facility by developing and implementing a series of barriers specifically designed to prevent recurrence of this significant and impactful event. The barriers included steps to inactivate or remove potential virus particles from the many raw materials used in cell culture processing. Additionally, analytical testing barriers provided protection of the downstream processing areas should a culture contamination occur, and robust virus clearance capability provided further assurance of virus safety should a low level contamination go undetected. This conference proceeding will review Genentech's approach, and lessons learned, in minimizing virus contamination risk in cell culture processes through multiple layers of targeted barriers designed to deliver biologics products with high success rates.

NACA Conference on Some Problems of Aircraft Operation: A Compilation of the Papers Presented

NASA Technical Reports Server (NTRS)

1950-01-01

This volume contains copies of the technical papers presented at the NACA Conference on Some Problems of Aircraft Operation on October 9 and 10, 1950 at the Lewis Flight Propulsion Laboratory. This conference was attended by members of the aircraft industry and military services. The original presentation and this record are considered as complementary to, rather than as substitutes for, the Committee's system of complete and formal reports. A list of the conferees is included. [Contents include four subject areas: Atmospheric Turbulence and its Effect on Aircraft Operation; Some Aspects of Aircraft Safety - Icing, Ditching and Fire; Aerodynamic Considerations for High-Speed Transport Airplanes; Propulsion Considerations for High-Speed Transport Airplanes.

Thermal structures and materials for high-speed flight; Collection of Papers of the 1st Thermal Structures Conference, University of Virginia, Charlottesville, Nov. 13-15, 1990

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thornton, E.A.

1992-01-01

The present conference discusses aerobrake-maneuver vehicle aerothermodynamics, aerothermal issues in the structural design of high speed vehicles, laser surface-alloying of superlight metals with ceramic surfaces, high-temperature Al alloys for supersonic and hypersonic vehicles, advanced metallics for high temperature airframes, novel materials for engine applications, and the development status of computational methods for high temperature structural design. Also discussed are a transient thermal-structural analysis using adaptive unstructured remeshing and mesh movement, the FEM thermoviscoplastic analysis of aerospace structures, hot-structures testing techniques, a thermal-structural analysis of a carbon-carbon/refractory metal heat pipe-cooled leading edge, dynamic effects in thermoviscoplastic structures, microlevel thermal effects inmore » metal-matrix composites (MMCs), thermomechanical effects in the plasma spray manufacture of MMC monotapes, and intelligent HIP processing. Most of the presentations at this conference were abstracted previously (see A91-16027 to A91-16047).« less

DoD High Performance Computing Modernization Program Users Group Conference (HPCMP UGC 2011) Held in Portland, Oregon on June 20-23, 2011

DTIC Science & Technology

2011-06-01

4. Conclusion The Web -based AGeS system described in this paper is a computationally-efficient and scalable system for high- throughput genome...method for protecting web services involves making them more resilient to attack using autonomic computing techniques. This paper presents our initial...20–23, 2011 2011 DoD High Performance Computing Modernzation Program Users Group Conference HPCMP UGC 2011 The papers in this book comprise the

High Temperature Polymer Matrix Composites

NASA Technical Reports Server (NTRS)

1985-01-01

These are the proceedings of the High Temperature Polymer Matrix Composites Conference held at the NASA Lewis Research Center on March 16 to 18, 1983. The purpose of the conference is to provide scientists and engineers working in the field of high temperature polymer matrix composites an opportunity to review, exchange, and assess the latest developments in this rapidly expanding area of materials technology. Technical papers are presented in the following areas: (1) matrix development; (2) adhesive development; (3) characterization; (4) environmental effects; and (5) applications.

AMSAHTS 1990: Advances in Materials Science and Applications of High Temperature Superconductors

NASA Technical Reports Server (NTRS)

Bennett, Larry H. (Editor); Flom, Yury (Editor); Moorjani, Kishin (Editor)

1991-01-01

This publication is comprised of abstracts for oral and poster presentations scheduled for AMSAHTS '90. The conference focused on understanding high temperature superconductivity with special emphasis on materials issues and applications. AMSAHTS 90, highlighted the state of the art in fundamental understanding of the nature of high-Tc superconductivity (HTSC) as well as the chemistry, structure, properties, processing and stability of HTSC oxides. As a special feature of the conference, space applications of HTSC were discussed by NASA and Navy specialists.

Missile aerodynamics; Proceedings of the Conference, Monterey, CA, Oct. 31-Nov. 2, 1988

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mendenhall, M.R.; Nixon, D.; Dillenius, M.F.E.

1989-01-01

The present conference discusses the development status of predictive capabilities for missile aerodynamic characteristics, the application of experimental techniques to missile-release problems, prospective high-performance missile designs, the use of lateral jet controls for missile guidance, and the integration of stores on modern tactical aircraft. Also discussed are semiempirical aerodynamic methods for preliminary design, high angle-of-attack behavior for an advanced missile, and the dynamic derivatives of missiles and fighter-type configurations at high angles-of-attack.

Biology of extinction risk in marine fishes

PubMed Central

Reynolds, John D; Dulvy, Nicholas K; Goodwin, Nicholas B; Hutchings, Jeffrey A

2005-01-01

We review interactions between extrinsic threats to marine fishes and intrinsic aspects of their biology that determine how populations and species respond to those threats. Information is available on the status of less than 5% of the world's approximately 15 500 marine fish species, most of which are of commercial importance. By 2001, based on data from 98 North Atlantic and northeast Pacific populations, marine fishes had declined by a median 65% in breeding biomass from known historic levels; 28 populations had declined by more than 80%. Most of these declines would be sufficient to warrant a status of threatened with extinction under international threat criteria. However, this interpretation is highly controversial, in part because of a perception that marine fishes have a suite of life history characteristics, including high fecundity and large geographical ranges, which might confer greater resilience than that shown by terrestrial vertebrates. We review 15 comparative analyses that have tested for these and other life history correlates of vulnerability in marine fishes. The empirical evidence suggests that large body size and late maturity are the best predictors of vulnerability to fishing, regardless of whether differences among taxa in fishing mortality are controlled; there is no evidence that high fecundity confers increased resilience. The evidence reviewed here is of direct relevance to the diverse criteria used at global and national levels by various bodies to assess threat status of fishes. Simple life history traits can be incorporated directly into quantitative assessment criteria, or used to modify the conclusions of quantitative assessments, or used as preliminary screening criteria for assessment of the ∼95% of marine fish species whose status has yet to be evaluated either by conservationists or fisheries scientists. PMID:16243696

Biology of extinction risk in marine fishes.

PubMed

Reynolds, John D; Dulvy, Nicholas K; Goodwin, Nicholas B; Hutchings, Jeffrey A

2005-11-22

We review interactions between extrinsic threats to marine fishes and intrinsic aspects of their biology that determine how populations and species respond to those threats. Information is available on the status of less than 5% of the world's approximately 15500 marine fish species, most of which are of commercial importance. By 2001, based on data from 98 North Atlantic and northeast Pacific populations, marine fishes had declined by a median 65% in breeding biomass from known historic levels; 28 populations had declined by more than 80%. Most of these declines would be sufficient to warrant a status of threatened with extinction under international threat criteria. However, this interpretation is highly controversial, in part because of a perception that marine fishes have a suite of life history characteristics, including high fecundity and large geographical ranges, which might confer greater resilience than that shown by terrestrial vertebrates. We review 15 comparative analyses that have tested for these and other life history correlates of vulnerability in marine fishes. The empirical evidence suggests that large body size and late maturity are the best predictors of vulnerability to fishing, regardless of whether differences among taxa in fishing mortality are controlled; there is no evidence that high fecundity confers increased resilience. The evidence reviewed here is of direct relevance to the diverse criteria used at global and national levels by various bodies to assess threat status of fishes. Simple life history traits can be incorporated directly into quantitative assessment criteria, or used to modify the conclusions of quantitative assessments, or used as preliminary screening criteria for assessment of the approximately 95% of marine fish species whose status has yet to be evaluated either by conservationists or fisheries scientists.

Level I academic trauma center integration as a model for sustaining combat surgical skills: The right surgeon in the right place for the right time.

PubMed

Hight, Rachel A; Salcedo, Edgardo S; Martin, Sean P; Cocanour, Christine S; Utter, Garth; Galante, Joseph M

2015-06-01

As North Atlantic Treaty Organization (NATO) countries begin troop withdrawal from Afghanistan, military medicine needs programs for combat surgeons to retain the required knowledge and surgical skills. Each military branch runs programs at various Level I academic trauma centers to deliver predeployment training and provide a robust trauma experience for deploying surgeons. Outside of these successful programs, there is no system-wide mechanism for nondeploying military surgeons to care for a high volume of critically ill trauma patients on a regular basis in an educational environment that promotes continued professional development. We hypothesize that fully integrated military-civilian relationship regional Level I trauma centers provide a surgical experience more closely mirroring that seen in a Role III hospital than local Level II and Level III trauma center or medical treatment facilities. We characterized the Level I trauma center practice using the number of trauma resuscitations, operative trauma/acute care surgery procedures, number of work shifts, operative density (defined as the ratio of operative procedures/days worked), and frequency of educational conferences. The same parameters were collected from two NATO Role III hospitals in Afghanistan during the peak of Operation Enduring Freedom. Data for two civilian Level II trauma centers, two civilian Level III trauma centers, and a Continental United States Military Treatment Facility without trauma designation were collected. The number of trauma resuscitations, number of 24-hour shifts, operative density, and educational conferences are shown in the table for the Level I trauma center compared with the different institutions. Civilian center trauma resuscitations and operative density were highest at the Level I trauma center and were only slightly lower than what was seen in Afghanistan. Level II and III trauma centers had lower numbers for both. The Level I trauma center provided the most frequent educational opportunities. In a Level I academic trauma center integrated program, military and civilian surgeons have the same clinical and educational responsibilities: rounding and operating, managing critical care patients, covering trauma/acute care surgery call, and mentoring surgery residents in an integrated residency program. The Level I trauma center experience most closely mimics the combat surgeon experience seen at NATO Role III hospitals in Afghanistan compared with other civilian trauma centers. At high-volume Level I trauma centers, military surgeons will have a comprehensive trauma practice, including dedicated educational opportunities. We recommend integrated programs with Level I academic trauma centers as the primary mechanism for sustaining military combat surgical skills in the future.

Rocky Mountain High-Tech: LITA's Denver Conference.

ERIC Educational Resources Information Center

Flagg, Gordon

1992-01-01

Reports on the third national conference of the American Library Association's Library and Information Technology Association, which was held September 13-16, 1992, in Denver, Colorado. Program highlights are summarized, including virtual communities, virtual reality, the electronic library, artificial intelligence and expert-systems, navigating…

The Crossroads Model

ERIC Educational Resources Information Center

Settlage, John; Johnston, Adam

2014-01-01

"As we've attended professional conferences over the years, we've noticed an interesting phenomenon--the most animated, high-quality conversations often take place outside the meeting rooms," write Settlage and Johnston. Educators often feel frustrated when conferences are dominated by lecture-style presentations. To address…

Glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 plays a critical role in the lipolytic processing of chylomicrons

PubMed Central

Beigneux, Anne P.; Davies, Brandon S. J.; Gin, Peter; Weinstein, Michael M.; Farber, Emily; Qiao, Xin; Peale, Franklin; Bunting, Stuart; Walzem, Rosemary L.; Wong, Jinny S.; Blaner, William S.; Ding, Zhi-Ming; Melford, Kristan; Wongsiriroj, Nuttaporn; Shu, Xiao; de Sauvage, Fred; Ryan, Robert O.; Fong, Loren G.; Bensadoun, André; Young, Stephen G.

2007-01-01

Summary The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LpL) along the luminal surface of the capillaries. However, the endothelial cell molecule that facilitates chylomicron processing by LpL has not yet been defined. Here, we show that glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 (GPIHBP1) plays a critical role in the lipolytic processing of chylomicrons. Gpihbp1-deficient mice exhibit a striking accumulation of chylomicrons in the plasma, even on a low-fat diet, resulting in milky plasma and plasma triglyceride levels as high as 5,000 mg/dl. Normally, Gpihbp1 is expressed highly in heart and adipose tissue, the same tissues that express high levels of LpL. In these tissues, GPIHBP1 is located on the luminal face of the capillary endothelium. Expression of GPIHBP1 in cultured cells confers the ability to bind both LpL and chylomicrons. These studies strongly suggest that GPIHBP1 is an important platform for the LpL-mediated processing of chylomicrons in capillaries. PMID:17403372

Renewable Electricity Futures (Presentation)

DOE Office of Scientific and Technical Information (OSTI.GOV)

DeMeo, E.

2012-08-01

This presentation library summarizes findings of NREL's Renewable Electricity Futures study, published in June 2012. RE Futures investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. It was presented at Wind Powering America States Summit. The Summit, which follows the American Wind Energy Association's (AWEA's) annual WINDPOWER Conference and Exhibition, provides state Wind Working Groups, state energy officials, U.S. Energy Department and national laboratory representatives, and professional and institutional partners an opportunity to review successes, opportunities, and challenges for wind energy and plan future collaboration.

Albanian women in physics

NASA Astrophysics Data System (ADS)

Deda, Antoneta; Alushllari, Mirela; Mico, Silvana

2015-12-01

In this report, presented at the 5th IUPAP International Conference on Women in Physics, we describe the status of women physicists in Albania and offer some statistical data illustrating the present situation. Undergraduate physics enrollment by girls is high and stable, more women are receiving financial support for doctoral studies, women are well represented in recent academic promotions, and recently women scientists have been appointed to several leadership positions. However, both women and men are challenged by the overall low levels of funding for research and by issues of availability and affordability of child care.

Second International Conference on Near-Field Optical Analysis: Photodynamic Therapy and Photobiology Effects

NASA Technical Reports Server (NTRS)

Bulgher, Debra L. (Editor); Morrison, Dennis

2002-01-01

The International NASA/DARPA Photobiology Conference held at the Johnson Space Center in Houston/TX demonstrated where low level laser therapy (LLLT), respectively low intensity light activated biostimulation (LILAB) and nanotechnological applications employing photobiomodulation techniques will presumably go in the next ten years. The conference was a continuation of the 1st International Conference on Nearfield Optical Analysis organized by Andrei Sommer (ENSOMA Lab, University of Ulm, Germany) in November 2000 at Castle Reisenburg, Germany, which started with a group of ten scientists from eight different countries. The 1st conference was co-sponsored by the American Chemical Society to evaluate the molecular mechanism of accelerated and normal wound healing processes. The 2nd conference was co-sponsored by DARPA, NASA-JSC and the Medical College of Wisconsin. Despite the short time between events, the 2nd conference hosted 40 international experts form universities, research institutes, agencies and the industry. The materials published here are expected to become milestones forming a novel platform in biomedical photobiology. The multidisciplinary group of researchers focused on LLLT/LILAB-applications under extreme conditions expected to have beneficial effects particularly in space, on submarines, and under severe battlefield conditions. The group also focused on novel technologies with possibilities allowing investigating the interaction of light with biological systems, molecular mechanisms of wound healing, bone regeneration, nerve regeneration, pain modulation, as well as biomineralization and biofilm formulation processes induced by nanobacteria.

PREFACE: International Congress on Energy Fluxes and Radiation Effects (EFRE-2014)

NASA Astrophysics Data System (ADS)

2014-11-01

The International Congress on Energy Fluxes and Radiation Effects 2014 (EFRE 2014) was held in Tomsk, Russia, on September 21-26, 2014. The organizers of the Congress were the Institute of High Current Electronics SB RAS and Tomsk Polytechnic University. EFRE 2014 combines three international conferences which are regularly held in Tomsk, Russia: the 18th International Symposium on High-Current Electronics (18th SHCE), the 12th International Conference on Modification of Materials with Particle Beams and Plasma Flows (12th CMM) and the 16th International Conference on Radiation Physics and Chemistry of Condensed Matter (16th RPC). The International Conference on Radiation Physics and Chemistry of Condensed Matter is a traditional representative forum devoted to the discussion of the fundamental problems of physical and chemical non-linear processes in condensed matter (mainly inorganic dielectrics) under the action of particle and photon beams of all types including pulsed power laser radiation. The International Symposium on High-Current Electronics is held biannually in Tomsk, Russia. The program of the conferences covers a wide range of scientific and technical areas including pulsed power technology, ion and electron beams, high-power microwaves, plasma and particle beam sources, modification of materials, and pulsed power applications in chemistry, biology and medicine. The 12th International Conference on Modification of Materials with Particle Beams and Plasma Flows is devoted to the discussion of the fundamental and applied issues in the field of modification of materials properties with particle beams and plasma flows. The six-day Congress brought together more than 250 specialists and scientists from different countries and organizations and provided an excellent opportunity to exchange knowledge, make oral contributions and poster presentations, and initiate discussion on the topics of interest. The proceedings were edited by Victor Lisitsyn, Vladimir Lopatin, and Anna Bogdan. We appreciate the contribution of the invited speakers and all participants, as well as sponsors "Intech Analytics" and "MICROSPLAV" for making the Congress successful.

Snail phenotypic variation and stress proteins: do different heat response strategies contribute to Waddington's widget in field populations?

PubMed

Köhler, Heinz-R; Lazzara, Raimondo; Dittbrenner, Nils; Capowiez, Yvan; Mazzia, Christophe; Triebskorn, Rita

2009-03-15

On the basis of studies with laboratory strains of Drosophila and Arabidopsis, it has been hypothesized that potential buffers to the expression of phenotypic morphological variation, such as Hsp90 and possibly Hsp70, represent important components of Waddington's widget, which may confer capacitive evolution. As studies on field populations of living organisms to test this hypothesis are lacking, we tested whether a heat response strategy involving high stress protein levels is associated with low morphological variation and vice versa, using four natural populations of Mediterranean pulmonate snails. In response to 8 hr of elevated temperatures, a population of Xeropicta derbentina with uniform shell pigmentation pattern showed remarkably high Hsp70 but low Hsp90 levels. In contrast, a highly variable population of Cernuella virgata kept both Hsp90 and Hsp70 levels low when held at diverse though environmentally relevant temperatures. Two other populations (Theba pisana and another X. derbentina population) with intermediate variation in shell pigmentation pattern were also intermediate in inducing Hsp70, though Hsp90 was maintained at a low level. The observed correlation of stress protein levels and coloration pattern variation provide the first indirect evidence for an association of stress proteins with Waddington's widget under natural conditions.

Stress tolerance in plants via habitat-adapted symbiosis

USGS Publications Warehouse

Rodriguez, R.J.; Henson, J.; Van Volkenburgh, E.; Hoy, M.; Wright, L.; Beckwith, F.; Kim, Y.-O.; Redman, R.S.

2008-01-01

We demonstrate that native grass species from coastal and geothermal habitats require symbiotic fungal endophytes for salt and heat tolerance, respectively. Symbiotically conferred stress tolerance is a habitat-specific phenomenon with geothermal endophytes conferring heat but not salt tolerance, and coastal endophytes conferring salt but not heat tolerance. The same fungal species isolated from plants in habitats devoid of salt or heat stress did not confer these stress tolerances. Moreover, fungal endophytes from agricultural crops conferred disease resistance and not salt or heat tolerance. We define habitat-specific, symbiotically-conferred stress tolerance as habitat-adapted symbiosis and hypothesize that it is responsible for the establishment of plants in high-stress habitats. The agricultural, coastal and geothermal plant endophytes also colonized tomato (a model eudicot) and conferred disease, salt and heat tolerance, respectively. In addition, the coastal plant endophyte colonized rice (a model monocot) and conferred salt tolerance. These endophytes have a broad host range encompassing both monocots and eudicots. Interestingly, the endophytes also conferred drought tolerance to plants regardless of the habitat of origin. Abiotic stress tolerance correlated either with a decrease in water consumption or reactive oxygen sensitivity/generation but not to increased osmolyte production. The ability of fungal endophytes to confer stress tolerance to plants may provide a novel strategy for mitigating the impacts of global climate change on agricultural and native plant communities.The ISME Journal (2008) 2, 404-416; doi:10.1038/ismej.2007.106; published online 7 February 2008. ?? 2008 International Society for Microbial Ecology All rights reserved.

Mutational analysis and genotype-phenotype relation in familial hypercholesterolemia: The SAFEHEART registry.

PubMed

Bourbon, Mafalda; Alves, Ana Catarina; Alonso, Rodrigo; Mata, Nelva; Aguiar, Pedro; Padró, Teresa; Mata, Pedro

2017-07-01

Familial hypercholesterolemia (FH) is an autosomal dominant disease of cholesterol metabolism that confers an increased risk of premature atherosclerotic cardiovascular disease (ASCVD). Therefore, early identification and treatment of these patients can improve prognosis and reduce the burden of cardiovascular mortality. The aim of this work was to perform the mutational analysis of the SAFEHEART (Spanish Familial Hypercholesterolaemia Cohort Study) registry. The study recruited 2938 individuals with genetic diagnosis of FH belonging to 775 families. Statistical analysis was performed using SPSS v23. A total of 194 variants have been detected in this study, 24 of them were never described before. About 88% of the patients have a pathogenic or likely pathogenic variant. Patients with null variants have a more severe phenotype than patients with defective variants, presenting with significantly higher levels of atherogenic particles (total cholesterol, LDL-cholesterol and apolipoprotein B). This study shows the molecular characteristics of the FH patients included in the SAFEHEART registry and the relationship with the phenotypic expression. The majority of the genetic variants are considered to be pathogenic or likely pathogenic, which confers a high level of confidence to the entry and follow-up data analysis performed with this registry concerning FH patients' prognosis, treatment and survival. Copyright © 2017 Elsevier B.V. All rights reserved.

Accessibility Guidelines for Astronomy and Astrophysics Meetings

NASA Astrophysics Data System (ADS)

Monkiewicz, Jacqueline; Murphy, Nicholas; Diaz-Merced, Wanda Liz; Aarnio, Alicia; Knierman, Karen; AAS Working Group for Accessibility and Disability

2018-01-01

Attendance at meetings and conferences is a critical component of an astronomer's professional life, providing opportunities for presenting one's work, staying current in the field, career networking, and scientific collaboration. Exclusion from these gatherings due to lack of accessibility and accommodation failure is a reality for disabled astronomers, and contributes substantially to low levels of representation in the senior-most levels of the field. We present a preview of the AAS Working Group for Accessibility and Disability's best practice recommendations for meetings accessibility. Applying the principles of universal access and barrier-free design, we model a paradigm of anticipating and removing accessibility barriers in advance, rather than putting the burden of requesting accommodation solely on disabled astronomers and students. We cite several professional and nonprofessional societies identified as meetings accessibility exemplars, and model our guidelines on their best practices. We establish standards for accessibility budgeting, venue choice, publication of policies online, designating point persons, and identifying barriers. We make recommendations for oral and poster presentations, event registration, receptions and banquets, excursions, and other typical conference activities. For meetings which are constrained by fixed budgets and venue choice, we identify a number of low cost/high reward accessibility steps which might still have a large beneficial impact. We likewise provide adapted recommendations for low budget meetings. THIS IS A POSTER LOCATED IN THE AAS BOOTH

The Annual African American Conference on Diabetes: evolving program evaluation with evolving program implementation.

PubMed

Houston, Jacquelyn M; Martin, Maurice; Williams, Joel E; Hill, Rhonda L

2006-01-01

According to 2003 Behavioral Risk Factor Surveillance System data, South Carolina has the fourth highest rate of overall diabetes among the 50 states (9.3%) but the second highest rate among African Americans (15.5%). Nationwide, African Americans are disproportionately affected by diabetes. In addition, 40% of the African American population in South Carolina lives in a rural area, and approximately 26% live at or below the poverty level. Lack of access to health care and diabetes education are additional barriers for people with diabetes and their families. Since 1997, the South Carolina Diabetes Prevention and Control Program and the Diabetes Today Advisory Council have sponsored the African American Conference on Diabetes, which targets African Americans with diabetes, their families, and their caregivers. This article describes the evolution of the conference and its evaluation. In 2002, we conducted focus groups with 20 African American conference attendees with diabetes to 1) assess the program's effects, 2) determine how to reach more individuals, and 3) improve programming. In 2004, we incorporated the preconference and postconference Diabetes Understanding Scale survey to assess the cognitive impact of the conference on participants. Focus group results revealed that participants wanted to attend the conference because of the opportunity to increase their knowledge and change their behaviors through 1) education, 2) social support, 3) resources, and 4) logistics. Self-rated understanding increased significantly after the conference for each cognitive understanding item on the Diabetes Understanding Scale. Focus group results suggested that participants who continue to attend the conference year after year may improve diabetes self-management skills. A quantitative evaluation showed that this 1-day diabetes education conference significantly increased short-term, self-rated cognitive understanding of diabetes behaviors.

A Self-Aware Machine Platform in Manufacturing Shop Floor Utilizing MTConnect Data

DTIC Science & Technology

2014-10-02

condition monitoring , and equipment time to failure prediction in manufacturing 1 ANNUAL CONFERENCE OF THE PROGNOSTICS AND HEALTH MANAGEMENT SOCIETY 2014 589...Component Level Health Monitoring and Prediction One of the characteristics of a self-aware machine is to be able to detect its components...the annual conference of the prognostics and health management society. Filzmoser, P., Garrett, R. G., & Reimann, C . (2005). Mul- tivariate outlier

Mathematics: Perspectives on Applications. Proceedings of the Annual Fall Conference of the Association of Teachers of Mathematics in New England (Manchester, New Hampshire, November 1974).

ERIC Educational Resources Information Center

Cote, Normand H., Ed.

This publication contains the substance of all papers submitted at the fall 1974 Association of Teachers of Mathematics in New England (ATMNE) conference. As the title indicates, the focus of the publication is directed toward mathematical applications. The 25 papers cover topics ranging from applications at the elementary school level to those…

Transportation Education and Training. Meeting the Challenge. Proceedings of the Conference on Surface Transportation Education and Training (Williamsburg, Virginia, October 28-31, 1984). Special Report 210.

ERIC Educational Resources Information Center

National Academy of Sciences - National Research Council, Washington, DC. Transportation Research Board.

This report contains the findings of a conference held to define the skills and educational background needed by new transportation professionals at all levels, to review the education and training currently being offered in this field, and to recommend other concepts and actions that will enhance transportation education and training. The…

The National Educational Science Planning Conference.

DTIC Science & Technology

1983-01-27

OF STANDARDS-1963-A =7 FTD-ID(RS)T-1606-82 FOREIGN TECHNOLOGY DIVISION THE NATIONAL EDUCATIONAL SCIENCE PLANNING CONFERENCE DTIC EECTE %%C.. D...institute were abolished; people were laid off. Many officials and teachers never learned education theories and do not know anything about S Sponsored by...levels of education must learn educational sciences in order to master the objective laws of educational work. *: We must turn laymen into professionals

Blueprint for Action: Dialogues from Wingspread II. Proceedings of the Conference on Adolescent Pregnancy: State Action on Adolescent Pregnancy (2nd, Racine, Wisconsin, August 10-12, 1986).

ERIC Educational Resources Information Center

Interstate Conference of Employment Security Agencies, Inc., Washington, DC.

The purpose of the conference reported in this document was to improve and coordinate state-level efforts to ameliorate the crisis of adolescent pregnancy. The document includes summaries of addresses by Edgar May, vice-president of the American Public Welfare Association's board of directors; Ann Rosewater, staff director of the Select Committee…

PREFACE: The International Conference on Highly Frustrated Magnetism HFM2008

NASA Astrophysics Data System (ADS)

Eremin, Ilya; Brenig, Wolfram; Kremer, Reinhard; Litterst, Jochen

2009-01-01

The International Conference on Highly Frustrated Magnetism 2008 (HFM2008) took place on 7-12 September 2008 at the Technische Universität Carolo-Wilhelmina zu Braunschweig, Germany. This conference was the fourth event in a series of meetings, which started in Waterloo, Canada (HFM 2000), followed by the second one in Grenoble, France (HFM 2003), and the third meeting in Osaka, Japan (HFM 2006). HFM2008 attracted more than 220 participants from all over the world. The number of participants of the HFM conference series has been increasing steadily, from about 80 participants at HFM 2000, to 120 participants at HFM 2003, and 190 participants at HFM 2006, demonstrating that highly frustrated magnetism remains a rapidly growing area of research in condensed matter physics. At the end of HFM2008 it was decided that the next International Conference on Highly Frustrated Magnetism will be held in Baltimore, USA in 2010. HFM2008 saw four plenary talks by R Moessner, S Nakatsuji, S-W Cheong, and S Sachdev, 18 invited presentations, 30 contributed talks and about 160 poster presentations from all areas of frustrated magnetism. The subjects covered by the conference included: Kagome systems Itinerant frustrated systems Spinels and pyrochlore materials Triangular systems Unconventional order and spin liquids Chain systems Chain systems Novel frustrated systems This volume of Journal of Physics: Conference Series contains the proceedings of HFM2008 with 83 papers that provide a scientific record of the scientific topics covered by the conference. All articles have been refereed by experts in the field. It is our hope that the reader will enjoy and profit from the HFM2008 Proceedings. Ilya Eremin Proceedings Editor Wolfram Brenig, Reinhard Kremer, and Jochen Litterst Co-Editors International Advisory Board L Balents (USA) F Becca (Italy) S Bramwell (UK) P Fulde (Germany) B D Gaulin (Canada) J E Greedan (Canada) A Harrison (France) Z Hiroi (Japan) H Kawamura (Japan) A Keren (Israel) C Lacroix (France) C Lhuillier (France) A Loidl (Germany) G Misguich (France) J Richter (Germany) A M Olés (Poland) P Schiffer (USA) R Stern (Estonia) O Tchernyshyov (USA) M R. Valenti (Germany) G Zwicknagl (Germany) International Program Committee W Brenig (Germany) C Broholm (USA) M Gingras (Canada) K Ueda (Japan) P Mendels (France) F Mila (Switzerland) R Moessner (Germany) Conference photograph On behalf of the HFM2008 Organizing Committee, I wish to express my sincere thanks to everyone who supported us in organizing and setting up HFM2008. Especially, I would like to thank the European Science Foundation and the Max-Planck-Institut für Festkörperforschung for the generous financial support, the Technische Universität Braunschweig and the City of Braunschweig for hosting the conference, all colleagues who served on the Advisory and Program Board, the Referees, and last but not least, the staff members from Stuttgart and Braunschweig, Mrs Gisela Siegle, Mrs Regine Noack and Mrs Katharina Schnettler, for their helpful and invaluable assistance. Reinhard Kremer

Proceedings of the ninth national conference on undergraduate research, 1995. Volume 3

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yearout, R.D.

The Ninth National Conference on Undergraduate Research (NCUR 95) was held at Union College in Schenectady, New York. This annual celebration of undergraduate scholarly activity continues to elicit strong nation-wide support and enthusiasm among both students and faculty. Attendance was nearly 1,650, which included 1,213 student oral and poster presenters. For the second year in a row, many student papers had to be rejected for presentation at NCUR due to conference size limitations. Thus, submitted papers for presentation at NCUR 95 were put through a careful review process before acceptance. Those students who have been selected to have their papermore » appear in these Proceedings have been through yet a second review process. As a consequence, their work has been judged to represent an impressive level of achievement at the undergraduate level. Volume 3 contains papers related to Biological Sciences (46 papers); Chemical Sciences (21 papers); and Environmental Sciences (7 papers).« less

A gene encoding maize caffeoyl-CoA O-methyltransferase confers quantitative resistance to multiple pathogens.

PubMed

Yang, Qin; He, Yijian; Kabahuma, Mercy; Chaya, Timothy; Kelly, Amy; Borrego, Eli; Bian, Yang; El Kasmi, Farid; Yang, Li; Teixeira, Paulo; Kolkman, Judith; Nelson, Rebecca; Kolomiets, Michael; L Dangl, Jeffery; Wisser, Randall; Caplan, Jeffrey; Li, Xu; Lauter, Nick; Balint-Kurti, Peter

2017-09-01

Alleles that confer multiple disease resistance (MDR) are valuable in crop improvement, although the molecular mechanisms underlying their functions remain largely unknown. A quantitative trait locus, qMdr 9.02 , associated with resistance to three important foliar maize diseases-southern leaf blight, gray leaf spot and northern leaf blight-has been identified on maize chromosome 9. Through fine-mapping, association analysis, expression analysis, insertional mutagenesis and transgenic validation, we demonstrate that ZmCCoAOMT2, which encodes a caffeoyl-CoA O-methyltransferase associated with the phenylpropanoid pathway and lignin production, is the gene within qMdr 9.02 conferring quantitative resistance to both southern leaf blight and gray leaf spot. We suggest that resistance might be caused by allelic variation at the level of both gene expression and amino acid sequence, thus resulting in differences in levels of lignin and other metabolites of the phenylpropanoid pathway and regulation of programmed cell death.

Strategies for encouraging patient/family member partnerships with the health care team.

PubMed

Ahmann, Elizabeth; Dokken, Deborah

2012-01-01

The 5th International Conference of the Institute for Patient- and Family-Centered Care (IPFCC), held in Washington, DC, from June 4-6, 2012, offered an opportunity for almost 1,000 conference participants to share and learn about exciting new patient- and family-centered initiatives occurring across the U.S. and in many other countries. One focus addressed by keynote and plenary speakers, as well as numerous conference sessions and poster presentations, was how nurses and other health care professionals can encourage patients and family members to become partners with their health care teams. Various presenters shared strategies ranging from initial approaches to acknowledging family members as part of the team and offering simple, non-threatening roles in care provision, to policies and approaches inviting increased participation in health care encounters, to higher level involvement in the care planning process, and to partnership roles extending beyond care of the individual child and family. A wealth of ideas can be implemented at various levels by individual nurses, units, and health care institutions.

Biophotonics: the big picture

NASA Astrophysics Data System (ADS)

Marcu, Laura; Boppart, Stephen A.; Hutchinson, Mark R.; Popp, Jürgen; Wilson, Brian C.

2018-02-01

The 5th International Conference on Biophotonics (ICOB) held April 30 to May 1, 2017, in Fremantle, Western Australia, brought together opinion leaders to discuss future directions for the field and opportunities to consider. The first session of the conference, "How to Set a Big Picture Biophotonics Agenda," was focused on setting the stage for developing a vision and strategies for translation and impact on society of biophotonic technologies. The invited speakers, panelists, and attendees engaged in discussions that focused on opportunities and promising applications for biophotonic techniques, challenges when working at the confluence of the physical and biological sciences, driving factors for advances of biophotonic technologies, and educational opportunities. We share a summary of the presentations and discussions. Three main themes from the conference are presented in this position paper that capture the current status, opportunities, challenges, and future directions of biophotonics research and key areas of applications: (1) biophotonics at the nano- to microscale level; (2) biophotonics at meso- to macroscale level; and (3) biophotonics and the clinical translation conundrum.

Proceedings of the ninth national conference on undergraduate research, 1995. Volume 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yearout, R.D.

The Ninth National Conference on Undergraduate Research (NCUR 95) was held at Union College in Schenectady, New York. This annual celebration of undergraduate scholarly activity continues to elicit strong nation-wide support and enthusiasm among both students and faculty. Attendance was nearly 1,650, which included 1,213 student oral and poster presenters. For the second year in a row, many student papers had to be rejected for presentation at NCUR due to conference size limitations. Thus, submitted papers for presentation at NCUR 95 were put through a careful review process before acceptance. Those students who have been selected to have their papermore » appear in these Proceedings have been through yet a second review process. As a consequence, their work has been judged to represent an impressive level of achievement at the undergraduate level. Volume 1 contains papers related to Arts and Humanities (52 papers), and Social and Behavioral Sciences (64 papers).« less

Addressing the Underrepresentation of Women in Physics at Multiple Levels

NASA Astrophysics Data System (ADS)

Greco, Shannon; Dominguez, Arturo; Ortiz, Deedee; Zwicker, Andrew

2016-10-01

APS provides support to several universities and research institutions to host Conferences for Undergraduate Women in Physics (CUWiP). The goal of these Conferences is to provide practical tools and a community to help women persist in physics and STEM careers. This is particularly relevant for the DPP where women make up only 7% of the membership. In January 2017, Princeton University and the Princeton Plasma Physics Laboratory (PPPL) will host a CUWiP. CUWiP and the Science Undergraduate Laboratory Internship (SULI) program expose undergraduates to the variety of possible careers in plasma physics and fusion energy in academia, government labs or private industry. We will report on the success of a number of PPPL programs to engage women at all levels in physics and highlight how programs such as CUWiP and SULI contribute to this goal. Special thanks to the Department of Energy for supporting PPPL's education programs and to APS for supporting the Conference for Undergraduate Women in Physics.

Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment.

PubMed

Gomez, James E; Kaufmann-Malaga, Benjamin B; Wivagg, Carl N; Kim, Peter B; Silvis, Melanie R; Renedo, Nikolai; Ioerger, Thomas R; Ahmad, Rushdy; Livny, Jonathan; Fishbein, Skye; Sacchettini, James C; Carr, Steven A; Hung, Deborah T

2017-02-21

Antibiotic resistance arising via chromosomal mutations is typically specific to a particular antibiotic or class of antibiotics. We have identified mutations in genes encoding ribosomal components in Mycobacterium smegmatis that confer resistance to several structurally and mechanistically unrelated classes of antibiotics and enhance survival following heat shock and membrane stress. These mutations affect ribosome assembly and cause large-scale transcriptomic and proteomic changes, including the downregulation of the catalase KatG, an activating enzyme required for isoniazid sensitivity, and upregulation of WhiB7, a transcription factor involved in innate antibiotic resistance. Importantly, while these ribosomal mutations have a fitness cost in antibiotic-free medium, in a multidrug environment they promote the evolution of high-level, target-based resistance. Further, suppressor mutations can then be easily acquired to restore wild-type growth. Thus, ribosomal mutations can serve as stepping-stones in an evolutionary path leading to the emergence of high-level, multidrug resistance.

PREFACE: International Conference on Computing in High Energy and Nuclear Physics (CHEP 2012)

NASA Astrophysics Data System (ADS)

Ernst, Michael; Düllmann, Dirk; Rind, Ofer; Wong, Tony

2012-12-01

The International Conference on Computing in High Energy and Nuclear Physics (CHEP) was held at New York University on 21- 25 May 2012. CHEP is a major series of international conferences for physicists and computing professionals from the High Energy and Nuclear Physics community and related scientific and technical fields. The CHEP conference provides a forum to exchange information on computing progress and needs for the community, and to review recent, ongoing and future activities. CHEP conferences are held at roughly 18-month intervals, alternating between Europe, Asia, the Americas and other parts of the world. Recent CHEP conferences have been held in Taipei, Taiwan (2010); Prague, Czech Republic (2009); Victoria, Canada (2007); Mumbai, India (2006); Interlaken, Switzerland (2004); San Diego, United States (2003); Beijing, China (2001); Padova, Italy (2000). CHEP 2012 was organized by Brookhaven National Laboratory (BNL) and co-sponsored by New York University. The organizational structure for CHEP consists of an International Advisory Committee (IAC) which sets the overall themes of the conference, a Program Organizing Committee (POC) that oversees the program content, and a Local Organizing Committee (LOC) that is responsible for local arrangements (lodging, transportation and social events) and conference logistics (registration, program scheduling, conference site selection and conference proceedings). There were over 500 attendees with a program that included plenary sessions of invited speakers, a number of parallel sessions comprising around 125 oral and 425 poster presentations and industrial exhibitions. We thank all the presenters for the excellent scientific content of their contributions to the conference. Conference tracks covered topics on Online Computing, Event Processing, Distributed Processing and Analysis on Grids and Clouds, Computer Facilities, Production Grids and Networking, Software Engineering, Data Stores and Databases and Collaborative Tools. We would like to thank Brookhaven Science Associates, New York University, Blue Nest Events, the International Advisory Committee, the Program Committee and the Local Organizing Committee members for all their support and assistance. We also would like to acknowledge the support provided by the following sponsors: ACEOLE, Data Direct Networks, Dell, the European Middleware Initiative and Nexsan. Special thanks to the Program Committee members for their careful choice of conference contributions and enormous effort in reviewing and editing the conference proceedings. The next CHEP conference will be held in Amsterdam, the Netherlands on 14-18 October 2013. Conference Chair Michael Ernst (BNL) Program Committee Daniele Bonacorsi, University of Bologna, Italy Simone Campana, CERN, Switzerland Philippe Canal, Fermilab, United States Sylvain Chapeland, CERN, Switzerland Dirk Düllmann, CERN, Switzerland Johannes Elmsheuser, Ludwig Maximilian University of Munich, Germany Maria Girone, CERN, Switzerland Steven Goldfarb, University of Michigan, United States Oliver Gutsche, Fermilab, United States Benedikt Hegner, CERN, Switzerland Andreas Heiss, Karlsruhe Institute of Technology, Germany Peter Hristov, CERN, Switzerland Tony Johnson, SLAC, United States David Lange, LLNL, United States Adam Lyon, Fermilab, United States Remigius Mommsen, Fermilab, United States Axel Naumann, CERN, Switzerland Niko Neufeld, CERN, Switzerland Rolf Seuster, TRIUMF, Canada Local Organizing Committee Maureen Anderson, John De Stefano, Mariette Faulkner, Ognian Novakov, Ofer Rind, Tony Wong (BNL) Kyle Cranmer (NYU) International Advisory Committee Mohammad Al-Turany, GSI, Germany Lothar Bauerdick, Fermilab, United States Ian Bird, CERN, Switzerland Dominique Boutigny, IN2P3, France Federico Carminati, CERN, Switzerland Marco Cattaneo, CERN, Switzerland Gang Chen, Institute of High Energy Physics, China Peter Clarke, University of Edinburgh, United Kingdom Sridhara Dasu, University of Wisconsin-Madison, United States Günter Duckeck, Ludwig Maximilian University of Munich, Germany Richard Dubois, SLAC, United States Michael Ernst, BNL, United States Ian Fisk, Fermilab, United States Gonzalo Merino, PIC, Spain John Gordon, STFC-RAL, United Kingdom Volker Gülzow, DESY, Germany Frederic Hemmer, CERN, Switzerland Viatcheslav Ilyin, Moscow State University, Russia Nobuhiko Katayama, KEK, Japan Alexei Klimentov, BNL, United States Simon C. Lin, Academia Sinica, Taiwan Milos Lokajícek, FZU Prague, Czech Republic David Malon, ANL, United States Pere Mato Vila, CERN, Switzerland Mauro Morandin, INFN CNAF, Italy Harvey Newman, Caltech, United States Farid Ould-Saada, University of Oslo, Norway Ruth Pordes, Fermilab, United States Hiroshi Sakamoto, University of Tokyo, Japan Alberto Santoro, UERJ, Brazil Jim Shank, Boston University, United States Dongchul Son, Kyungpook National University, South Korea Reda Tafirout, TRIUMF, Canada Stephen Wolbers, Fermilab, United States Frank Wuerthwein, UCSD, United States

Climatic Impact Assessment Program, Proceedings of the Survey Conference, February 15-16, 1972

DOT National Transportation Integrated Search

1972-09-01

The report contains the proceedings of a survey conference, concerning the impact of climatic changes which might result from perturbation of the upper atmosphere by the exhaust effluent of a world high-altitude aircraft fleet, as projected to 1990. ...

Special Issue of Selected Papers from Visualization and Data Analysis 2011

NASA Technical Reports Server (NTRS)

Kao, David L.; Wong, Pak Chung

2012-01-01

This special issue features the best papers that were selected from the 18th SPIE Conference on Visualization and Data Analysis (VDA 2011). This annual conference is a major international forum for researchers and practitioners interested in data visualization and analytics research, development, and applications. VDA 2011 received 42 high-quality submissions from around the world. Twenty-four papers were selected for full conference papers. The top five papers have been expanded and reviewed for this special issue.

On the Mitigation of Solar Index Variability for High Precision Orbit Determination in Low Earth Orbit

DTIC Science & Technology

2016-09-16

Astrodynamics Specialist Conference, No. AAS 15-752, American Astronautical Society, 2015. 3Center, N. S. W. P., “Estimated Ap Forecast Verification,” http...atmospheric density modeling,” AIAA/AAS astrodynamics specialist conference and exhibit , 2008, pp. 18–21. 6Marcos, F. A., “Accuracy of atmospheric... Specialist Conference and Exhibit, Honolulu, Hawaii , 2008. 17Tobiska, W. K., Bowman, B. R., and Bouwer, S. D., “Solar and Geomagnetic Indices for

Real-Time, General-Purpose, High-Speed Signal Processing Systems for Underwater Research. Proceedings of a Working Level Conference held at Supreme Allied Commander, Atlantic Anti-Submarine Warfare Research Center (SACLANTCEN) on 18-21 September 1979. Part 2. Sessions IV to VI.

DTIC Science & Technology

1979-12-01

ACTIVATED, SYSTEM OPERATION AND TESTING MASCOT PROVIDES: 1. SYSTEM BUILD SOFTWARE COMPILE-TIME CHECKS,a. 2. RUN-TIME SUPERVISOR KERNEL, 3, MONITOR AND...p AD-AOBI 851 SACLANT ASW RESEARCH CENTRE LA SPEZIA 11ITALY) F/B 1711 REAL-TIME, GENERAL-PURPOSE, HIGH-SPEED SIGNAL PROCESSING SYSTEM -- ETC (U) DEC 79...Table of Contents Table of Contents (Cont’d) Page Signal processing language and operating system (w) 23-1 to 23-12 by S. Weinstein A modular signal

Evolution of the Pseudomonas aeruginosa Aminoglycoside Mutational Resistome In Vitro and in the Cystic Fibrosis Setting.

PubMed

López-Causapé, Carla; Rubio, Rosa; Cabot, Gabriel; Oliver, Antonio

2018-04-01

Inhaled administration of high doses of aminoglycosides is a key maintenance treatment of Pseudomonas aeruginosa chronic respiratory infections in cystic fibrosis (CF). We analyzed the dynamics and mechanisms of stepwise high-level tobramycin resistance development in vitro and compared the results with those of isogenic pairs of susceptible and resistant clinical isolates. Resistance development correlated with fusA1 mutations in vitro and in vivo. pmrB mutations, conferring polymyxin resistance, were also frequently selected in vitro In contrast, mutational overexpression of MexXY, a hallmark of aminoglycoside resistance in CF, was not observed in in vitro evolution experiments. Copyright © 2018 American Society for Microbiology.

Building Community: A 2005 Conference for Education and Public Outreach Professionals

NASA Astrophysics Data System (ADS)

Slater, T. F.; Bennett, M.; Garmany, K.

2004-12-01

In support of the Astronomical Society of the Pacific's (ASP) mission to increase the understanding and appreciation of astronomy, the ASP will host an international meeting in September 14-16, 2005 in Tucson focused on building and supporting a vibrant and connected community of individuals and groups engaged in educational and public outreach (EPO) in the disciplines of astronomy, astrobiology, space, and earth science. This conference is specially designed for individuals who are bringing the excitement of astronomy to non-astronomers. This community of science communicators includes: NASA and NSF-funded EPO program managers, developers, evaluators, PIOs, and others who support outreach efforts by government agencies and commercial industries; Scientists working with or assigned to EPO programs or efforts; Individuals working in formal science education: K-14 schools/colleges and minority-serving institutions as faculty or curriculum developers; Informal educators working in widely diverse settings including science centers, planetariums, museums, parks, and youth programs; Amateur astronomers involved in or interested in engaging children and adults in the excitement of astronomy; Public outreach specialists working in observatories, visitor centers, public information offices, and in multimedia broadcasting and journalism. The conference goals are to improve the quality and increase the effective dissemination of EPO materials, products, and programs through a multi-tiered professional development conference utilizing: Visionary plenary talks; Highly interactive panel discussions; Small group workshops and clinics focused on a wide range of EPO topics including evaluation and dissemination, with separate sessions for varying experience levels; Poster and project exhibition segments; Opportunities to increase program leveraging through structured and unstructured networking sessions; and Individual program action planning sessions. There will both separate and combined sessions for individuals working in formal, informal, public outreach, and scientific communications settings; and specific professional development sessions.

2011 Photosynthesis Gordon Research Conference & Seminar (June 11-17, 2011, Davidson College, Davidson, North Carolina)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prof. Krishna Niyogi

2011-06-17

Photosynthesis is the biological process that converts solar energy into chemical energy. Elucidation of the mechanisms of photosynthetic energy conversion at a molecular level is fundamentally important for understanding the biology of photosynthetic organisms, for optimizing biological solar fuels production, and for developing biologically inspired approaches to solar energy conversion. The 2011 Gordon Conference on Photosynthesis will present cutting-edge research focusing on the biochemical aspects of photosynthesis, including: (1) structure, assembly, and function of photosynthetic complexes; (2) the mechanism of water splitting by PSII; (3) light harvesting and quenching; (4) alternative electron transport pathways; (5) biosynthesis of pigments and cofactors;more » and (6) improvement of photosynthesis for bioenergy and food production. Reflecting the interdisciplinary nature of photosynthesis research, a diverse group of invited speakers will represent a variety of scientific approaches to investigate photosynthesis, such as biochemistry, molecular genetics, structural biology, systems biology, and spectroscopy. Highly interactive poster sessions provide opportunities for graduate students and postdocs to present their work and exchange ideas with leaders in the field. One of the highlights of the Conference is a session featuring short talks by junior investigators selected from the poster presentations. The collegial atmosphere of the Photosynthesis GRC, with programmed discussion sessions as well as informal gatherings in the afternoons and evenings, enables participants to brainstorm, exchange ideas, and forge new collaborations. For the second time, this Conference will be immediately preceded by a Gordon Research Seminar on Photosynthesis (June 11-12, 2011, at the same location), with a focus on 'Photosynthesis, Bioenergy, and the Environment.' The GRS provides an additional opportunity for graduate students and postdocs to present their research, and it provides a mechanism to encourage active participation by junior scientists interested in photosynthesis and its applications.« less

How do the Institutes on Teaching and Learning (ITLs) nurture the members of the Physiology Educators Community of Practice (PECOP)?

PubMed

Goodman, Barbara E

2017-09-01

Do you teach physiology? Do you use best practices when you teach physiology? Have you ever thought about conducting educational research? Do you need collaborators to help with ideas for educational research or to expand your research populations? The American Physiological Society (APS) Teaching Section has developed a biennial Institute on Teaching and Learning (ITL) through the APS Conference Program to address these issues. The first institute was held in June 2014, and the second institute was held in June 2016. A Physiology Education Community of Practice (PECOP) was created to help connect the institute participants and other physiology educators and to share evidence-based teaching in physiology at all education levels. The 2018 APS ITL will be the next meeting to learn best practices, to share ideas with colleagues, and to find collaborators in improving the teaching of physiology for students. The meeting will include workshops modeling best practices, plenary talks about hot new issues in physiology and science education, and poster sessions and informal meals to discuss interests with colleagues. Even if one's primary responsibility is bench research or administration, the training from the institute will improve efficiency and effectiveness when teaching. The two prior ITLs (2014 and 2016) were highly evaluated by educators of both undergraduate and professional students who spent a week together emphasizing improvement in their teaching. This paper reports the outcomes of the 2016 ITL and encourages participation in the upcoming ITL in Madison, WI, June 18-22, 2018. Watch the APS Conference site for more information about the 2018 ITL (http://www.the-aps.org/mm/Conferences/APS-Conferences). Copyright © 2017 the American Physiological Society.

Complementary epistasis involving Sr12 explains adult plant resistance to stem rust in Thatcher wheat (Triticum aestivum L.).

PubMed

Rouse, Matthew N; Talbert, Luther E; Singh, Davinder; Sherman, Jamie D

2014-07-01

Quantitative trait loci conferring adult plant resistance to Ug99 stem rust in Thatcher wheat display complementary gene action suggesting multiple quantitative trait loci are needed for effective resistance. Adult plant resistance (APR) in wheat (Triticum aestivum L.) to stem rust, caused by Puccinia graminis f. sp. tritici (Pgt), is desirable because this resistance can be Pgt race non-specific. Resistance derived from cultivar Thatcher can confer high levels of APR to the virulent Pgt race TTKSK (Ug99) when combined with stem rust resistance gene Sr57 (Lr34). To identify the loci conferring APR in Thatcher, we evaluated 160 RILs derived from Thatcher crossed to susceptible cultivar McNeal for field stem rust reaction in Kenya for two seasons and in St. Paul for one season. All RILs and parents were susceptible as seedlings to race TTKSK. However, adult plant stem rust severities in Kenya varied from 5 to 80 %. Composite interval mapping identified four quantitative trait loci (QTL). Three QTL were inherited from Thatcher and one, Sr57, was inherited from McNeal. The markers closest to the QTL peaks were used in an ANOVA to determine the additive and epistatic effects. A QTL on 3BS was detected in all three environments and explained 27-35 % of the variation. The peak of this QTL was at the same location as the Sr12 seedling resistance gene effective to race SCCSC. Epistatic interactions were significant between Sr12 and QTL on chromosome arms 1AL and 2BS. Though Sr12 cosegregated with the largest effect QTL, lines with Sr12 were not always resistant. The data suggest that Sr12 or a linked gene, though not effective to race TTKSK alone, confers APR when combined with other resistance loci.

17th Space Photovoltaic Research and Technology Conference

NASA Technical Reports Server (NTRS)

Jenkins, Phillip (Compiler)

2002-01-01

The 17th Space Photovoltaic Research and Technology (SPRAT XVII) Conference was held September 11-13, 2001, at the Ohio Aerospace Institute (OAI) in Cleveland, Ohio. The SPRAT conference, hosted by the Photovoltaic and Space Environments Branch of the NASA Glenn Research Center, brought together representatives of the space photovoltaic community from around the world to share the latest advances in space solar technology. This year's conference continued to build on many of the trends shown in SPRAT XVI; the use of new high-efficiency cells for commercial use and the development of novel array concepts such as Boeing's Solar Tile concept. In addition, new information was presented on space environmental interactions with solar arrays.

The green vaccine: A global strategy to combat infectious and autoimmune diseases

PubMed Central

Davoodi-Semiromi, Abdoreza; Samson, Nalapalli; Daniell, Henry

2009-01-01

Plant derived oral green vaccines eliminate expenses associated with fermenters, purification, cold storage/transportation and sterile delivery. Green vaccines are expressed via the plant nuclear or chloroplast genomes. Chloroplast expression has advantages of hyper-expression of therapeutic proteins (10,000 copies of trans-gene per cell), efficient oral delivery and transgene containment via maternal inheritance. To date, 23 vaccine antigens against 16 different bacterial, viral or protozoan pathogens have been expressed in chloroplasts. Mice subcutaneously immunized with the chloroplast derived anthrax protective antigen conferred 100% protection against lethal doses of the anthrax toxin. Oral immunization (ORV) of F1-V antigens without adjuvant conferred greater protection (88%) against 50-fold lethal dose of aerosolized plague (Yersinia pestis) than subcutaneous (SQV) immunization (33%). Oral immunization of malarial vaccine antigens fused to the cholera antigen (CTB-AMA1/CTB-Msp1) conferred prolonged immunity (50% life span), 100% protection against cholera toxin challenge and inhibited proliferation of the malarial parasite. Protection was correlated with antigen-specific titers of intestinal, serum IgA & IgG1 in ORV and only IgG1 in SQV mice, but no other immunoglobulin. High level expression in edible plant chloroplasts ideal for oral delivery and long-term immunity observed should facilitate development of low cost human vaccines for large populations, at times of outbreak. PMID:19430198

Transaction costs, externalities and information technology in health care.

PubMed

Ferguson, B; Keen, J

1996-01-01

This paper discusses some of the economic issues which underpin the rationale for investment in information and communications technologies (ICTs). Information imperfections lead to significant transaction costs (search, negotiating and monitoring) which in turn confer a negative externality on parties involved in exchange. This divergence in private and social costs leads to a degree of resource misallocation (efficiency loss) which, uncorrected, results in a sub-optimal outcome. Traditional solutions to this problem are to rely upon direct government action to reduce the costs of transacting between market agents, or to employ tax/subsidy measures and other legislative action to achieve the desired market outcome. Three key policy questions are raised in the context of the NHS purchaser/provider relationship. Firstly, what is the optimum level of transaction costs; secondly, can ICTs assist in lowering the level of transaction costs to the optimum level; thirdly, who should bear the investment cost in reducing the level of transaction costs? The issue of property rights in different information systems is discussed and raises interesting policy questions about how much investment should be undertaken centrally rather than devolved to a more local level. In some ways this economic framework offers a post hoc justification of why different ICT systems have been introduced at various levels of the NHS. Essentially this reduces to the problem of externalities: providing good information confers a positive externality: not providing relevant, timely and accurate information confers a negative externality, by increasing further the level of transaction costs. The crucial role which ICT systems can play lies in attempting to reduce the level of transaction costs and driving the market towards what Dahlman has described as the transaction-cost-constrained equilibrium.

Reorienting adolescent sexual and reproductive health research: reflections from an international conference.

PubMed

Michielsen, Kristien; De Meyer, Sara; Ivanova, Olena; Anderson, Ragnar; Decat, Peter; Herbiet, Céline; Kabiru, Caroline W; Ketting, Evert; Lees, James; Moreau, Caroline; Tolman, Deborah L; Vanwesenbeeck, Ine; Vega, Bernardo; Verhetsel, Elizabeth; Chandra-Mouli, Venkatraman

2016-01-13

On December 4th 2014, the International Centre for Reproductive Health (ICRH) at Ghent University organized an international conference on adolescent sexual and reproductive health (ASRH) and well-being. This viewpoint highlights two key messages of the conference--(1) ASRH promotion is broadening on different levels and (2) this broadening has important implications for research and interventions--that can guide this research field into the next decade. Adolescent sexuality has long been equated with risk and danger. However, throughout the presentations, it became clear that ASRH and related promotion efforts are broadening on different levels: from risk to well-being, from targeted and individual to comprehensive and structural, from knowledge transfer to innovative tools. However, indicators to measure adolescent sexuality that should accompany this broadening trend, are lacking. While public health related indicators (HIV/STIs, pregnancies) and their behavioral proxies (e.g., condom use, number of partners) are well developed and documented, there is a lack of consensus on indicators for the broader construct of adolescent sexuality, including sexual well-being and aspects of positive sexuality. Furthermore, the debate during the conference clearly indicated that experimental designs may not be the only appropriate study design to measure effectiveness of comprehensive, context-specific and long-term ASRH programmes, and that alternatives need to be identified and applied. Presenters at the conference clearly expressed the need to develop validated tools to measure different sub-constructs of adolescent sexuality and environmental factors. There was a plea to combine (quasi-)experimental effectiveness studies with evaluations of the development and implementation of ASRH promotion initiatives.

Electromagnetic Devices and Processes in Environment Protection: Post-Conference Materials.

DTIC Science & Technology

1994-09-09

the Response of Power Transmission and Distribution Lines to a Nuclear Detonation at a High Altitude" 5. R. Goleman, M. Pahczyk, M. Pawlot...processes are unfortunately endothermal ones. However, if necessary energy is produced via a C02-free way(e.g. using solar, hydro, wind, nuclear or...POST-CONFERENCE MATERIALS 31 DETERMINING THE RESPONSE OF POWER TRANSMISSION AND DISTRIBUTION LINES TO A NUCLEAR DETONATION AT A HIGH ALTITUDE

Computer conferencing: the "nurse" in the "Electronic School District".

PubMed

Billings, D M; Phillips, A

1991-01-01

As computer-based instructional technologies become increasingly available, they offer new mechanisms for health educators to provide health instruction. This article describes a pilot project in which nurses established a computer conference to provide health instruction to high school students participating in an electronic link of high schools. The article discusses computer conferencing, the "Electronic School District," the design of the nursing conference, and the role of the nurse in distributed health education.

Metallurgical coatings and thin films; Proceedings of the International Conference, 18th, San Diego, CA, Apr. 22-26, 1991. Vols. 1 & 2

NASA Technical Reports Server (NTRS)

Mcguire, Gary E. (Editor); Mcintyre, Dale C. (Editor); Hofmann, Siegfried (Editor)

1991-01-01

A conference on metallurgical coatings and thin films produced papers in the areas of coatings for use at high temperatures; hard coatings and deposition technologies; diamonds and related materials; tribological coatings/surface modifications; thin films for microelectronics and high temperature superconductors; optical coatings, film characterization, magneto-optics, and guided waves; and methods for characterizing films and modified surfaces.