Proceedings of the Annual Conference of the Association for International Agricultural and Extension Education (15th, Port of Spain, Trinidad and Tobago March 21-26, 1999).

ERIC Educational Resources Information Center

Richardson, John G., Ed.

This proceedings contains session topics: extension systems, extension programs, extension evaluation, program impacts, extension management, extension reform, experiential learning, program delivery, farming systems research, professional training and development, program strategies, teaching effectiveness, organizational leadership, extension…

Roles for ROS and hydrogen sulfide in the longevity response to germline loss in Caenorhabditis elegans.

PubMed

Wei, Yuehua; Kenyon, Cynthia

2016-05-17

In Caenorhabditis elegans, removing germ cells slows aging and extends life. Here we show that transcription factors that extend life and confer protection to age-related protein-aggregation toxicity are activated early in adulthood in response to a burst of reactive oxygen species (ROS) and a shift in sulfur metabolism. Germline loss triggers H2S production, mitochondrial biogenesis, and a dynamic pattern of ROS in specific somatic tissues. A cytoskeletal protein, KRI-1, plays a key role in the generation of H2S and ROS. These kri-1-dependent redox species, in turn, promote life extension by activating SKN-1/Nrf2 and the mitochondrial unfolded-protein response, respectively. Both H2S and, remarkably, kri-1-dependent ROS are required for the life extension produced by low levels of the superoxide-generator paraquat and by a mutation that inhibits respiration. Together our findings link reproductive signaling to mitochondria and define an inducible, kri-1-dependent redox-signaling module that can be invoked in different contexts to extend life and counteract proteotoxicity.

Nineteenth International Cosmic Ray Conference. HE Sessions, Volume 7

NASA Technical Reports Server (NTRS)

Jones, F. C. (Compiler)

1985-01-01

Papers submitted for presentation at the 19th International Cosmic ray Conference are compiled. This volume contains papers which address various aspects of extensive air showers (EAS) produced by energetic particles and gamma rays.

Thomas Graham, Jr.: Preparing for the 1995 NPT Conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1994-07-01

With attention increasingly focused on the critical nuclear Non-Proliferation Treaty (NPT) extension and review conference beginning in April 1995, Thomas Graham, Jr. plays a key role in negotiations to gain indefinite treaty extension during voting at the conference. He has been Arms Control and Disarmament Agency (ACDA) general counsel since 1983, served as acting director from January to November 1992 and since November 23, 1992, has been acting deputy director. Among other assignments, he served as legal advisor to the US SALT II delegation and senior ACDA representative to the US Intermediate-Range Nuclear Forces delegation in 1981-82. He was interviewedmore » May 26 by Jack Mendelsohn and Jon B. Wolfsthal.« less

Energy in Agriculture: Proceedings of a Conference-Workshop, Atlanta, Georgia, October 1-3, 1975.

ERIC Educational Resources Information Center

Southern Regional Education Board, Atlanta, GA.

This publication is the proceedings of a conference-workshop held in Atlanta, Georgia in October 1975. At this conference 13 papers were presented on various aspects of energy use in agriculture. Also included are the final reports of the extension, the teaching, and the research workshop groups. Title of papers include Energy in Agriculture and…

EPOXI Mission Press Conference

NASA Image and Video Library

2010-11-18

Dr. James Green, Director of Planetary Science, NASA Headquarters, at podium, speaks during a press conference, Thursday, Nov. 18, 2010, at NASA Headquarters in Washington. The press conference was held to discuss the Nov. 4 successful flyby of Comet Hartley 2 by NASA's EPOXI Mission Spacecraft. Images from the flyby provided scientists the most extensive observations of a comet in history. Photo Credit: (NASA/Paul E. Alers)

EPOXI Mission Press Conference

NASA Image and Video Library

2010-11-18

Pete Schultz, EPOXI scientist from Brown University, makes a point during a press conference, Thursday, Nov. 18, 2010, at NASA Headquarters in Washington. The press conference was held to discuss the Nov. 4 successful flyby of Comet Hartley 2 by NASA's EPOXI Mission Spacecraft. Images from the flyby provided scientists the most extensive observations of a comet in history. Photo Credit: (NASA/Paul E. Alers)

Increasing Understanding of Public Problems and Policies, 1994. [National Public Policy Education Conference (44th, Boise, Idaho, September 18-21, 1994).

ERIC Educational Resources Information Center

Halbrook, Steve A., Ed.; Grace, Teddee E., Ed.

The National Public Policy Education Conference is held annually to improve the policy education efforts of extension workers responsible for public affairs programs. The 1994 conference addressed the following topics: (1) ethical perspectives in public policy education; (2) transition of food and agricultural policy; (3) building human…

Midwest Research-to-Practice Annual Conference in Adult Continuing and Community Education. Conference Proceedings (11th, Manhattan, Kansas, October 8-9, 1992).

ERIC Educational Resources Information Center

Kansas State Univ., Manhattan. Coll. of Education.

A conference on research to practice in adult, continuing and community education included the following papers: "Education as a Community Intervention Strategy" (Ashcraft, Andrews); "Assessing Educational Needs of Adults: An Ohio Extension Example" (Bratkovich, Miller); "Questions and Issues Related to a Lack of Multicultural Research in Adult…

Mid-America and Its Future: 1989. Proceedings of a Four-State Economic Development Conference (13th, Shenandoah, Iowa, April 18, 1989).

ERIC Educational Resources Information Center

Kobberdahl, Wayne, Comp.

This volume contains summaries of presentations and excerpts from workshops at a conference organized by the Cooperative Extension Services of Iowa, Kansas, Nebraska, and Missouri. The conference brought together community officials and leaders from the four-state area to share experiences and gain new ideas about community development. Topics…

Conference Support, 23rd Western Photosynthesis Conference 2014, Final Technical Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wachter, Rebekka

The Western Photosynthesis Conference is a regional conference that is held on an annual basis to bring together researchers primarily from the Western United States to share their newest research advances on photosynthetic processes. The 23rd conference was focused on both fundamental and more applied research on the biological conversion of solar energy to various energy storage forms. Several particular areas of solar energy conversion were emphasized in this conference (see below). Some of these topics, such as carbon limitations on photosynthesis, biomimicry and phenotyping, have traditionally not been incorporated extensively in the Western Photosynthesis Conference. We found that thesemore » topics have substantially broadened of the scope of this meeting.« less

Influence of Cryogenic Treatments on the Wear Behavior of AISI 420 Martensitic Stainless Steel

NASA Astrophysics Data System (ADS)

Prieto, G.; Tuckart, W. R.

2017-11-01

The objective of the present work is to characterize the wear behavior of a cryogenically treated low-carbon AISI 420 martensitic stainless steel, by means of ball-on-disk tribological tests. Wear tests were performed under a range of applied normal loads and in two different environments, namely a petrolatum bath and an argon atmosphere. Wear tracks were analyzed by both optical and scanning electron microscopy and Raman spectroscopy to evaluate wear volume, track geometry, surface features and the tribolayers generated after testing. This paper is an extension of the work originally reported in the VIII Iberian Conference of Tribology (Prieto and Tuckart, in: Ballest Jiménez, Rodríguez Espinosa, Serrano Saurín, Pardilla Arias, Olivares Bermúdez (eds) VIII Iberian conference of tribology, Cartagena, 2015). In this study, it has been experimentally demonstrated that cryogenically treated specimens showed a wear resistance improvement ranging from 35 to 90% compared to conventionally treated ones.

EPOXI Mission Press Conference

NASA Image and Video Library

2010-11-18

Tim Larson, EPOXI Project Manager from the Jet Propulsion Laboratory in Pasadena, Calif., speaks during a press conference, Thursday, Nov. 18, 2010, at NASA Headquarters in Washington. The press conference was held to discuss the Nov. 4 successful flyby of Comet Hartley 2 by NASA's EPOXI Mission Spacecraft. Images from the flyby provided scientists the most extensive observations of a comet in history. Photo Credit: (NASA/Paul E. Alers)

National Literacy Mission: Problems and Prospects. Proceedings of the All India Adult Education Conference (41st, Aurangabad, India, October 28-31, 1988). Series 169.

ERIC Educational Resources Information Center

Saxena, J. C., Ed.; Sachdeva, J. L., Ed.

The conference reported in this document was convened by the Indian Adult Education Association in collaboration with the Adult Continuing Education & Extension Centre of Marathwada University. Attended by 230 delegates from throughout India, the conference focussed on ways of developing an all-out attack on the country's huge illiteracy…

Increasing Understanding of Public Problems and Policies: 1993. [Proceedings of the Annual Conference of the National Public Policy Education Committee (43rd, Clearwater Beach, Florida, September 12-15, 1993).

ERIC Educational Resources Information Center

Halbrook, Steve A., Ed.; Grace, Teddee E., Ed.

The annual conference of the National Public Policy Education Committee (NPPEC) is held to improve the policy education efforts of extension workers responsible for public affairs programs. This publication contains 26 conference papers: "Rural America and the Information Revolution: An Exploration of Possibilities and Potentialities"…

Induction of Cytoprotective Pathways Is Central to the Extension of Lifespan Conferred by Multiple Longevity Pathways

PubMed Central

Shore, David E.; Carr, Christopher E.; Ruvkun, Gary

2012-01-01

Many genetic and physiological treatments that extend lifespan also confer resistance to a variety of stressors, suggesting that cytoprotective mechanisms underpin the regulation of longevity. It has not been established, however, whether the induction of cytoprotective pathways is essential for lifespan extension or merely correlated. Using a panel of GFP-fused stress response genes, we identified the suites of cytoprotective pathways upregulated by 160 gene inactivations known to increase Caenorhabditis elegans longevity, including the mitochondrial UPR (hsp-6, hsp-60), the ER UPR (hsp-4), ROS response (sod-3, gst-4), and xenobiotic detoxification (gst-4). We then screened for other gene inactivations that disrupt the induction of these responses by xenobiotic or genetic triggers, identifying 29 gene inactivations required for cytoprotective gene expression. If cytoprotective responses contribute directly to lifespan extension, inactivation of these genes would be expected to compromise the extension of lifespan conferred by decreased insulin/IGF-1 signaling, caloric restriction, or the inhibition of mitochondrial function. We find that inactivation of 25 of 29 cytoprotection-regulatory genes shortens the extension of longevity normally induced by decreased insulin/IGF-1 signaling, disruption of mitochondrial function, or caloric restriction, without disrupting normal longevity nearly as dramatically. These data demonstrate that induction of cytoprotective pathways is central to longevity extension and identify a large set of new genetic components of the pathways that detect cellular damage and couple that detection to downstream cytoprotective effectors. PMID:22829775

Farmer's market, demonstration gardens, and research projects expand outreach of Extension Master Gardeners

Treesearch

Pamela J. Bennett; Ellen M. Bauske; Alison Stoven O' Connor; Jean Reeder; Carol Busch; Heidi A. Kratsch; Elizabeth Leger; Angela O' Callaghan; Peter J. Nitzche; Jim Downer

2013-01-01

Extension Master Gardener (EMG) volunteers are central to expanding the outreach and engagement of extension staff. A workshop format was used at the Annual Conference of the American Society for Horticultural Science on 31 July 2012 in Miami, FL to identify successful management techniques and projects that expand EMG volunteer outreach, leading to increased extension...

EPOXI Mission Press Conference

NASA Image and Video Library

2010-11-18

Jessica Sunshine, EPOXI Deputy Principal Investigator, University of Maryland, far right, discusses imagery sent back from the EPOXI Mission spacecraft during a press conference, Thursday, Nov. 18, 2010, at NASA Headquarters in Washington. The press conference was held to discuss the Nov. 4 successful flyby of Comet Hartley 2 by NASA's EPOXI Mission Spacecraft. Images from the flyby provided scientists the most extensive observations of a comet in history. Photo Credit: (NASA/Paul E. Alers)

EPOXI Mission Press Conference

NASA Image and Video Library

2010-11-18

Michael A'Hearn, EPOXI Principal Investigator, University of Maryland, holds a plastic bottle containing ice to illustrate a point during a press conference, Thursday, Nov. 18, 2010, at NASA Headquarters in Washington. The press conference was held to discuss the Nov. 4 successful flyby of Comet Hartley 2 by NASA's EPOXI Mission Spacecraft. Images from the flyby provided scientists the most extensive observations of a comet in history. Photo Credit: (NASA/Paul E. Alers)

The Role of the Church in Rural Development. Report on the Proceedings and Recommendations of the Working Conference (Salisbury, Rhodesia, August 27-30, 1972).

ERIC Educational Resources Information Center

Smith, G. A., Ed.; Jolson, A., Ed.

The proceedings of a national conference to examine the present situation and needs in rural areas of Rhodesia and to formulate a strategy of joint Christian participation in development are provided. The conference program centered around three main themes: Training Schemes, Extension and Development in Rural Areas, and Ecumenical Action in Rural…

Proceedings of the Next Generation Exploration Conference

NASA Technical Reports Server (NTRS)

Schingler, Robbie (Editor); Lynch, Kennda

2006-01-01

The Next Generation Exploration Conference (NGEC) brought together the emerging next generation of space leaders over three intensive days of collaboration and planning. The participants extended the ongoing work of national space agencies to draft a common strategic framework for lunar exploration, to include other destinations in the solar system. NGEC is the first conference to bring together emerging leaders to comment on and contribute to these activities. The majority of the three-day conference looked beyond the moon and focused on the "next destination": Asteroids, Cis-Lunar, Earth 3.0, Mars Science and Exploration, Mars Settlement and Society, and Virtual Worlds and Virtual Exploration.

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

This report consists of vugraphs of the presentations at the conference. The conference was divided into the following sessions: (1) First Generation Wire Development: Status and Issues; (2) First Generation Wire in Pre-Commercial Prototypes; (3) Second Generation Wire Development: Private Sector Progress and Issues; (4) Second Generation Wire Development: Federal Laboratories; and (5) Fundamental Research Issues for HTS Wire Development.

PRISMA-Children (C) and PRISMA-Protocol for Children (P-C) Extensions: a study protocol for the development of guidelines for the conduct and reporting of systematic reviews and meta-analyses of newborn and child health research.

PubMed

Kapadia, Mufiza Z; Askie, Lisa; Hartling, Lisa; Contopoulos-Ioannidis, Despina; Bhutta, Zulfiqar A; Soll, Roger; Moher, David; Offringa, Martin

2016-04-18

Paediatric systematic reviews differ from adult systematic reviews in several key aspects such as considerations of child tailored interventions, justifiable comparators, valid outcomes and child sensitive search strategies. Available guidelines, including PRISMA-P (2015) and PRISMA (2009), do not cover all the complexities associated with reporting systematic reviews in the paediatric population. Using a collaborative, multidisciplinary structure, we aim to develop evidence-based and consensus-based PRISMA-P-C (Protocol for Children) and PRISMA-C (Children) Extensions to guide paediatric systematic review protocol and completed review reporting. This project's methodology follows published recommendations for developing reporting guidelines and involves the following six phases; (1) establishment of a steering committee representing key stakeholder groups; (2) a scoping review to identify potential Extension items; (3) three types of consensus activities including meetings of the steering committee to achieve high-level decisions on the content and methodology of the Extensions, a survey of key stakeholders to generate a list of possible items to include in the Extensions and a formal consensus meeting to select the reporting items to add to, or modify for, the Extension; (4) the preliminary checklist items generated in phase III will be evaluated against the existing evidence and reporting practices in paediatric systematic reviews; (5) extension statements and explanation and elaboration documents will provide detailed advice for each item and examples of good reporting; (6) development and implementation of effective knowledge translation of the extension checklist, and an evaluation of the Extensions by key stakeholders. This protocol was considered a quality improvement project by the Hospital for Sick Children's Ethics Committee and did not require ethical review. The resultant checklists, jointly developed with all relevant stakeholders, will be disseminated through peer-reviewed journals as well as national and international conference presentations. Endorsement of the checklist will be sought simultaneously in multiple journals. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

PRISMA-Children (C) and PRISMA-Protocol for Children (P-C) Extensions: a study protocol for the development of guidelines for the conduct and reporting of systematic reviews and meta-analyses of newborn and child health research

PubMed Central

Kapadia, Mufiza Z; Askie, Lisa; Hartling, Lisa; Contopoulos-Ioannidis, Despina; Bhutta, Zulfiqar A; Soll, Roger; Moher, David; Offringa, Martin

2016-01-01

Introduction Paediatric systematic reviews differ from adult systematic reviews in several key aspects such as considerations of child tailored interventions, justifiable comparators, valid outcomes and child sensitive search strategies. Available guidelines, including PRISMA-P (2015) and PRISMA (2009), do not cover all the complexities associated with reporting systematic reviews in the paediatric population. Using a collaborative, multidisciplinary structure, we aim to develop evidence-based and consensus-based PRISMA-P-C (Protocol for Children) and PRISMA-C (Children) Extensions to guide paediatric systematic review protocol and completed review reporting. Methods and analysis This project's methodology follows published recommendations for developing reporting guidelines and involves the following six phases; (1) establishment of a steering committee representing key stakeholder groups; (2) a scoping review to identify potential Extension items; (3) three types of consensus activities including meetings of the steering committee to achieve high-level decisions on the content and methodology of the Extensions, a survey of key stakeholders to generate a list of possible items to include in the Extensions and a formal consensus meeting to select the reporting items to add to, or modify for, the Extension; (4) the preliminary checklist items generated in phase III will be evaluated against the existing evidence and reporting practices in paediatric systematic reviews; (5) extension statements and explanation and elaboration documents will provide detailed advice for each item and examples of good reporting; (6) development and implementation of effective knowledge translation of the extension checklist, and an evaluation of the Extensions by key stakeholders. Ethics and Dissemination This protocol was considered a quality improvement project by the Hospital for Sick Children's Ethics Committee and did not require ethical review. The resultant checklists, jointly developed with all relevant stakeholders, will be disseminated through peer-reviewed journals as well as national and international conference presentations. Endorsement of the checklist will be sought simultaneously in multiple journals. PMID:27091820

Papers presented to the Conference on Heat and Detachment in Crustal Extension on Continents and Planets

NASA Technical Reports Server (NTRS)

1985-01-01

Several topics relative to heat and detachment in crustal extension on continents and planets are discussed. Rifting on Venus, heat flow and continental breakup, magnetism, the mountains and tectonic processes of Io, and the ductile extension of planetary lithospheres are among the topics covered.

Proceedings: international conference on transfer of forest science knowledge and technology.

Treesearch

Cynthia Miner; Ruth Jacobs; Dennis Dykstra; Becky Bittner

2007-01-01

This proceedings compiles papers presented by extensionists, natural resource specialists, scientists, technology transfer specialists, and others at an international conference that examined knowledge and technology transfer theories, methods, and case studies. Theory topics included adult education, applied science, extension, diffusion of innovations, social...

A primer for effective organization of professional conferences.

PubMed

Werner, Susan E; Kenefick, Colleen

2005-01-01

The challenge of organizing a successful conference is a tremendous commitment requiring extensive preparation and teamwork. It is tempting but dangerous to underestimate the details needed to coordinate an outstanding event. Conferences follow a natural life cycle from proposal, gaining administrative support, planning, implementing, and then finally evaluating outcomes. These guidelines identify the tasks and areas of responsibilities required including setting objectives, budgeting, selecting a venue, publicity, programming, and working with vendors.

Selected papers from the 7th IEEE International Nanoelectronics Conference (INEC 2016) and the 5th International Symposium on Next-Generation Electronics (ISNE 2016)

NASA Astrophysics Data System (ADS)

Kok, Chi-Wah; Tam, Wing-Shan

2017-12-01

May is a busy but fruitful month of the year 2016, in which two renowned international conferences, the 7th IEEE International Nanoelectronics Conference (INEC 2016) and the 5th International Symposium on Next Generation Electronics (ISNE 2016), were successfully held in the technology hubs of Chengdu China and Hsinchu Taiwan, respectively. This special issue is a collection of selected research papers presented in these two conferences.

Glossary of Conference Terms: English, French, Arabic.

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Paris (France).

The results of an idea jointly conceived by the International Labour Office (ILO), the Food and Agriculture Organization of the United Nations (FAO) and the United Nations Educational, Scientific, and Cultural Organization (UNESCO), this work consists of three extensive glossaries of commonly used conference terms, classified under key words and…

Discussing Benefits and Risks of Tracheostomy: What Physicians Actually Say.

PubMed

Hebert, Lauren M; Watson, Anne C; Madrigal, Vanessa; October, Tessie W

2017-12-01

When contemplating tracheostomy placement in a pediatric patient, a family-physician conference is often the setting for the disclosure of risks and benefits of the procedure. Our objective was to compare benefits and risks of tracheostomy presented during family-physician conferences to an expert panel's recommendations for what should be presented. We conducted a retrospective review of 19 transcripts of audio-recorded family-physician conferences regarding tracheostomy placement in children. A multicenter, multidisciplinary expert panel of clinicians was surveyed to generate a list of recommended benefits and risks for comparison. Primary analysis of statements by clinicians was qualitative. Single-center PICU of a tertiary medical center. Family members who participated in family-physician conferences regarding tracheostomy placement for a critically ill child from April 2012 to August 2014. We identified 300 physician statements describing benefits and risks of tracheostomy. Physicians were more likely to discuss benefits than risks (72% vs 28%). Three broad categories of benefits were identified: 1) tracheostomy would limit the impact of being in the PICU (46%); 2) perceived obstacles of tracheostomy can be overcome (34%); and 3) tracheostomy optimizes respiratory health (20%). Risks fell into two categories: tracheostomy involves a big commitment (71%), and it has complications (29%). The expert panel's recommendations were similar to risks and benefits discussed during family conferences; however, they suggested physicians present an equal balance of discussion of risks and benefits. When discussing tracheostomy placement, physicians emphasized benefits that are shared by physicians and families while minimizing the risks. The expert panel recommended a balanced approach by equally weighing risks and benefits. To facilitate educated decision making, physicians should present a more extensive range of risks and benefits to families making this critical decision.

Next Generation Communications: Making IT Work. Pacific Telecommunications Council Annual Conference Proceedings (24th, Honolulu, Hawaii, January 13-17, 2002).

ERIC Educational Resources Information Center

Pacific Telecommunications Council, Honolulu, HI.

This proceedings includes the papers presented at the 2002 conference of the Pacific Telecommunications Council (PTC), with its theme "Next Generation Communications: Making IT Work." The PTC2002 annual conference seeks to focus on harnessing the complexities of the broadest range of communications technologies and services for the user.…

Bibliography of Research in Natural Language Generation

DTIC Science & Technology

1993-11-01

on 1397] Barbara J. Gross Focuing and description in Artifcial Intelligence (GWAI-88), Geseke, West natural language dialogues, In Joshi et al. (557...Proceedings of the Fifth Canadian Conference from information in a frame structure. Data and on Artificial Intelligence , pages Ŕ-24, London, Knowledge...generation workshops (IWNLGS, ENLGWS), natural language processing conferences (ANLP, TINLAP, SPEECH), artificial intelligence conferences (AAAI, SCA

Increasing Understanding of Public Problems and Policies; A Group Study of Four Topics in the Field of Extension Education.

ERIC Educational Resources Information Center

Farm Foundation, Chicago, IL.

Sixteen essays pertaining to agricultural extension education were the basis of the 18th National Agricultural Policy Conference, held September 10-18, 1968, at Sequoyah State Park, Wagoner, Oklahoma. Individual topics of papers include leadership training, Iowa State welfare, low income area community development, an urban extension pilot…

Multiplexed resequencing analysis to identify rare variants in pooled DNA with barcode indexing using next-generation sequencer.

PubMed

Mitsui, Jun; Fukuda, Yoko; Azuma, Kyo; Tozaki, Hirokazu; Ishiura, Hiroyuki; Takahashi, Yuji; Goto, Jun; Tsuji, Shoji

2010-07-01

We have recently found that multiple rare variants of the glucocerebrosidase gene (GBA) confer a robust risk for Parkinson disease, supporting the 'common disease-multiple rare variants' hypothesis. To develop an efficient method of identifying rare variants in a large number of samples, we applied multiplexed resequencing using a next-generation sequencer to identification of rare variants of GBA. Sixteen sets of pooled DNAs from six pooled DNA samples were prepared. Each set of pooled DNAs was subjected to polymerase chain reaction to amplify the target gene (GBA) covering 6.5 kb, pooled into one tube with barcode indexing, and then subjected to extensive sequence analysis using the SOLiD System. Individual samples were also subjected to direct nucleotide sequence analysis. With the optimization of data processing, we were able to extract all the variants from 96 samples with acceptable rates of false-positive single-nucleotide variants.

Action without frontiers. SADC meeting.

PubMed

Klouda, T

1997-02-01

The factors which affect AIDS and the transmission of HIV transcend national, racial, cultural, religious, political, and programmatic boundaries. The European Union and the Southern African Development Community (SADC) jointly held a conference in Lilongwe, Malawi, during December 4-6 to bring together senior officials from a wide range of development sectors in the 12 countries of the SADC region to examine the potential for regional, comprehensive action on relevant issues. Conference outcomes will be reviewed and agreed upon at a future regional ministerial meeting. Origins of the conference, innovative aspects of the conference, and regional and sectoral involvement are discussed. Employment, mining, medical drugs, education, and tourism were discussed extensively at the conference as separate sectors.

Utilization of Ancillary Studies in the Cytologic Diagnosis of Respiratory Lesions

PubMed Central

Layfield, Lester J.; Roy-Chowdhuri, Sinchita; Baloch, Zubair; Ehya, Hormoz; Geisinger, Kim; Hsiao, Susan J.; Lin, Oscar; Lindeman, Neal I.; Roh, Michael; Schmitt, Fernando; Sidiropoulos, Nikoletta; VanderLaan, Paul A.

2017-01-01

The Papanicolaou Society of Cytopathology has developed a set of guidelines for respiratory cytology including indications for sputum examination, bronchial washings and brushings, CT-guided FNA and endobronchial ultrasound guided fine needle aspiration (EBUS-FNA), as well as recommendations for classification and criteria, ancillary testing and post-cytologic diagnosis management and follow-up. All recommendation documents are based on the expertise of committee members, an extensive literature review, and feedback from presentations at national and international conferences. The guideline documents selectively present the results of these discussions. The present document summarizes recommendations for ancillary testing of cytologic samples. Ancillary testing including microbiologic, immunocytochemical, flow cytometric, and molecular testing, including next-generation sequencing are discussed. PMID:27561242

Illinois White House Conference on Families: State Report.

ERIC Educational Resources Information Center

1980

This report describes the process designed in Illinois to respond to President Carter's initiative for a White House Conference on Families. It also describes the product of that process: recommendations in ten topic areas of importance to the American family. Extensive discussions of such topics as children and parents, education, marriage,…

Resources for the Internet: Applications for Foreign Language Teachers.

ERIC Educational Resources Information Center

Finnemann, Michael D.

1995-01-01

A session of the Illinois Council on the Teaching of Foreign Languages (ICTFL) October 1995 conference dealing with Internet resources for second language teachers is summarized, and in extension of that information, World Wide Web resources for language teachers are enumerated. In the conference session seven types of Internet resource are…

Proceeding of the 2014 sorghum improvement conference of north america (SICNA)

USDA-ARS?s Scientific Manuscript database

The 2014 Sorghum Improvement Conference of North America (SICNA 2014) meeting was held at the Texas A&M AgriLife Research and Extension Center , Agnes, Corpus Christi, TX on June 25-27, 2014. The meeting was attended by about 80 participants representing a diverse cross section of the sorghum indus...

Proceedings of the Annual Conference of the Military Testing Association (16th).

ERIC Educational Resources Information Center

1974

The military utilizes tests extensively and should be aware of current testing problems. A conference composed of members from the business, educational, and military communities, both foreign and domestic, was held and these major issues addressed: (1) The Development of Training Requirements; (2) Personnel Assignment Using Interest Inventories;…

Proceedings of the second SISAL users` conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Feo, J T; Frerking, C; Miller, P J

1992-12-01

This report contains papers on the following topics: A sisal code for computing the fourier transform on S{sub N}; five ways to fill your knapsack; simulating material dislocation motion in sisal; candis as an interface for sisal; parallelisation and performance of the burg algorithm on a shared-memory multiprocessor; use of genetic algorithm in sisal to solve the file design problem; implementing FFT`s in sisal; programming and evaluating the performance of signal processing applications in the sisal programming environment; sisal and Von Neumann-based languages: translation and intercommunication; an IF2 code generator for ADAM architecture; program partitioning for NUMA multiprocessor computer systems;more » mapping functional parallelism on distributed memory machines; implicit array copying: prevention is better than cure ; mathematical syntax for sisal; an approach for optimizing recursive functions; implementing arrays in sisal 2.0; Fol: an object oriented extension to the sisal language; twine: a portable, extensible sisal execution kernel; and investigating the memory performance of the optimizing sisal compiler.« less

Architecture of conference control functions

NASA Astrophysics Data System (ADS)

Kausar, Nadia; Crowcroft, Jon

1999-11-01

Conference control is an integral part in many-to-many communications that is used to manage and co-ordinate multiple users in conferences. There are different types of conferences which require different types of control. Some of the features of conference control may be user invoked while others are for internal management of a conference. In recent years, ITU (International Telecommunication Union) and IETF (Internet Engineering Task Force) have standardized two main models of conferencing, each system providing a set of conference control functionalities that are not easily provided in the other one. This paper analyzes the main activities appropriate for different types of conferences and presents an architecture for conference control called GCCP (Generic Conference Control Protocol). GCCP interworks different types of conferencing and provides a set of conference control functions that can be invoked by users directly. As an example of interworking, interoperation of IETF's SIP and ITU's H.323 call control functions have been examined here. This paper shows that a careful analysis of a conferencing architecture can provide a set of control functions essential for any group communication model that can be extensible if needed.

Disturbances and Contradictions in an Online Conference

ERIC Educational Resources Information Center

Carr, Tony; Ludvigsen, Sten Runar

2017-01-01

This article analyses participant experiences and statements about perceived problems in two online conferences to identify tensions and disturbances relating to external factors, conference technology, online discussions and design choices and then considers the underlying contradictions within the conference systems which generate both positive…

An Historical Analysis of the Development of Selected Areas of University Extension Programs in the United States, 1900-1965, as Related in Professional Literature.

ERIC Educational Resources Information Center

Jessup, Michael Hyle

This study is concerned with the historical development of certain areas of university extension--credit and noncredit courses, correspondence study, and conferences, institutes, and short courses--which appear widespread and important in current extension programs. Credit and noncredit courses and correspondence study were among the earliest…

Foreword: The 12th International Conference on Vibrations at Surfaces (VAS 12) (Erice, 20 26 July 2007)

NASA Astrophysics Data System (ADS)

Benedek, Giorgio; Vattuone, Luca

2008-06-01

The 12th International Conference on Vibrations at Surfaces (VAS 12) took place from 20 26 July 2007 as an event of the International School of Solid State Physics at the Ettore Majorana Foundation and Centre for Scientific Culture, Erice (Italy). The format and special environment of the conference have contributed to its transition from a traditional, medium-size conference into a more effective workshop, with a series of lectures reporting the most recent developments in the field, two poster sessions presenting recent results and even works in progress being discussed. The papers collected in this issue cover the highlights of the conference very thoroughly. Quite a few novel aspects concerning vibrations at surfaces are represented here, for example: new aspects in surface phonon spectroscopy, such as the very recent progress in inelastic x-ray scattering, the first observation of the boson peak in disordered surfaces, progress in the theory of atom scattering inelastic resonances, the action spectroscopy, the study of polycrystalline surfaces with electron energy-loss spectroscopy etc; parallel developments in experimental vibrational studies of adsorbed phases, either inorganic or organic, with those in ab initio theoretical simulations; the theory of enhanced electron--phonon interaction in low dimensions (2D and 1D); the extension from the traditional realm of surface vibrations and spectroscopy to other aspects of surface dynamics, like friction and various nonlinear effects, and to relevant dynamical phenomena occurring at interfaces. Other novelties presented at the conference, but already published in recent issues of the Journal of Physics: Condensed Matter, are also worth mentioning: the spin-echo spectroscopy with 3He allowing for slow-dynamics spectroscopy at very high, unprecedented resolutions (2007 J. Phys.: Cond. Matter 19 300301 and 305010; the first demonstration of dissociative surface trapping of molecules (2007 J. Phys.: Cond. Matter 19 305003; the discovery of optical surface phonons in metals, solving a quarter of a century old controversy about surface acoustic resonances (2007 J. Phys.: Cond. Matter 19 305011). Future development of the VAS conference series could involve extending it to new areas directly involving surface vibrations which have traditionally been covered by other scientific communities. These are nonlinear optics (second-harmonic generation, femtosecond pump and probe experiments), surface acoustic waves (SAW) in THz domains with extension to dispersion effects and optical phonons, THz SAW applications to sensors and other devices, etc. The mature field of surface vibrations has many new branches into a wide range of applicative, mostly nanotechnological areas. The present VAS edition was intended to renew the conference and stimulate its evolution into new challenging directions. We believe that this special issue of the Journal of Physics: Condensed Matter will meet with the same large consensus gained at the 12th International Conference on Vibrations at Surfaces, and will foster new progress in the fields of surface dynamical phenomena and their applications. The next International Conference on Vibrations at Surfaces (VAS 13) will take place in the fall of 2009 in Orlando, Florida, and will be chaired by Professor Talat S Rahman, University of Central Florida. We gratefully acknowledge the Ettore Majorana Foundation and Centre for Scientific Culture, Erice (Italy) and its staff for excellent hospitality and support, and SPECS and Varian for financial aid.

Proceedings of the Annual Conference of the Military Testing Association (17th, Fort Benjamin Harrison, Indiana, September 15-19, 1975).

ERIC Educational Resources Information Center

1975

The 62 papers presented at the 1975 conference of the Military Testing Association cover almost all areas of military and occupational assessment and evaluation, and are arranged in 19 "common subject-matter groupings": Symposium (on Aptitude Testing), Training Extension Courses, Computerized Testing, Task Validation and Qualification…

Defining the Essentials for the Foreign Language Classroom. Selected Papers from the 1989 Central States Conference.

ERIC Educational Resources Information Center

McAlpine, Dave, Ed.; And Others

Selected papers from the 1989 Central State Conference on the Teaching of Foreign Languages include the following: "From Talk to Action: An Essential for Curricular Change" (June K. Phillips); "Comprehensible Input for Intermediate Foreign Language Students via Video" (Tracy David Terrell); "Developing Extensive Reading Skills: The Transition to…

Water Conservation with Water Saving Devices, Proceedings of a Conference. Extension Bulletin 421.

ERIC Educational Resources Information Center

Shelton, Theodore B., Ed.

Presented are six papers on water conservation which were presented at a conference in New Jersey. The first two papers present recommendations of the New Jersey Department of Environmental Protection on water conservation and a master plan for New Jersey's water supply needs. The following four papers discuss water conservation with water-saving…

Tinkering with Technology: A Library Workshop to Support 4-H Youth Development

ERIC Educational Resources Information Center

Hendrix, Beth; Williamson, Evan

2017-01-01

When University of Idaho (UI) Extension brought the Idaho 4-H Teen Conference to UI's main campus, the conference organizers collaborated with UI librarians to organize a workshop in the library's newly established makerspace, the Making, Innovating, and Learning Laboratory (MILL). In the MILL, the students used cutting-edge technology to foster…

Using Audience Response Devices for Extension Programming

ERIC Educational Resources Information Center

de Koff, Jason P.

2013-01-01

Audience response devices (ARDs), or "clickers," have traditionally been used in the classroom to take attendance, provide testing of current knowledge and knowledge gain, and assist with review of course topics. The ARDs were used at a recent Extension conference, which provided an opportunity to test how well this tool worked. Though…

Large-scale frequency- and time-domain quantum entanglement over the optical frequency comb (Conference Presentation)

NASA Astrophysics Data System (ADS)

Pfister, Olivier

2017-05-01

When it comes to practical quantum computing, the two main challenges are circumventing decoherence (devastating quantum errors due to interactions with the environmental bath) and achieving scalability (as many qubits as needed for a real-life, game-changing computation). We show that using, in lieu of qubits, the "qumodes" represented by the resonant fields of the quantum optical frequency comb of an optical parametric oscillator allows one to create bona fide, large scale quantum computing processors, pre-entangled in a cluster state. We detail our recent demonstration of 60-qumode entanglement (out of an estimated 3000) and present an extension to combining this frequency-tagged with time-tagged entanglement, in order to generate an arbitrarily large, universal quantum computing processor.

Stress Energy Tensor in LCFT and LOGARITHMIC Sugawara Construction

NASA Astrophysics Data System (ADS)

Kogan, Ian I.; Nichols, Alexander

We discuss the partners of the stress energy tensor and their structure in Logarithmic conformal field theories. In particular we draw attention to the fundamental differences between theories with zero and non-zero central charge. However they are both characterised by at least two independent parameters. We show how, by using a generalised Sugawara construction, one can calculate the logarithmic partner of T. We show that such a construction works in the c=-2 theory using the conformal dimension one primary currents which generate a logarithmic extension of the Kac-Moody algebra. This is an expanded version of a talk presented by A. Nichols at the conference on Logarithmic Conformal Field Theory and its Applications in Tehran Iran, 2001.

International Conference on Problems Related to the Stratosphere

NASA Technical Reports Server (NTRS)

Huntress, W., Jr.

1977-01-01

The conference focused on four main areas of investigation: laboratory studies and stratospheric chemistry and constituents, sources for and chemical budget of stratospheric halogen compounds, sources for and chemical budget of stratospheric nitrous oxide, and the dynamics of decision making on regulation of potential pollutants of the stratosphere. Abstracts of the scientific sessions of the conference as well as complete transcriptions of the panel discussions on sources for an atmospheric budget of holocarbons and nitrous oxide are included. The political, social and economic issues involving regulation of potential stratospheric pollutants were examined extensively.

Academic Advising: Transition and Continuity. Proceedings of the National Academic Advising Association Annual Region VII Conference (5th, Dallas, Texas, May 21-23, 1989).

ERIC Educational Resources Information Center

Hargrave, O. T., Ed.

Papers from the conference proceedings of the National Academic Advising Association are as follows: "Advising, Writing Centers, and Academic Services: Applications and Extensions of Student Developmental Theories" (M. Brooks and C. Murphy); "Development of an Expert System for Student Advisement" (J. Sullivan et al.); "Evaluating Advising: The…

42 CFR 137.424 - Is the recommended decision from the informal conference final for the Secretary?

Code of Federal Regulations, 2010 CFR

2010-10-01

... SELF-GOVERNANCE Appeals Pre-Award Disputes § 137.424 Is the recommended decision from the informal... from the informal conference, it may still appeal the initial decision within 30 days of receiving the... appeal within 30 days, or before the expiration of the extension it has received under § 137.426 , the...

76 FR 2109 - Next Generation Risk Assessment Public Dialogue Conference

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-12

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9246-7] Next Generation Risk Assessment Public Dialogue Conference Correction In notice document 2010-32977 appearing on page 82387 in the issue of Thursday, December 30, 2010, make the following correction: In the second column, below the signature date, the...

Understanding Air Pollution and Energy Choices Through ...

EPA Pesticide Factsheets

This is a joint presentation on two outreach activities - the PM sensor kit and the Generate game - at the National Science Teacher Association annual conference. This is a joint presentation on two outreach activities - the PM sensor kit and the Generate game - at the National Science Teacher Association annual conference.

Lifelong Learning Research Conference Proceedings (9th, College Park, Maryland, February 25-26, 1988).

ERIC Educational Resources Information Center

Rivera, William M., Comp.; Davis, Cynthia, Comp.

The following 26 papers, with abstracts and references, are included in these proceedings: "Panel: Continuing Professional Education in Cooperative Extension" (Robert L. Bruce, G. L. Carter, Jr., Ronald Jimmerson, Joan S. Thomson); "New Farm Families: Implications for Extension Educators" (Jane W. McGonigal, Robert L. Bruce); "The Experience of…

Interactive Whiteboards: A New Tool for Extension Education

ERIC Educational Resources Information Center

Schroeder, Mary M.; Burns, Connie S.; Reicks, Marla M.

2011-01-01

Use of interactive whiteboards (IWBs) in school classrooms and conference rooms is increasing. To evaluate the effectiveness of IWBs as a tool for Extension education, two groups of 3rd and 4th grade Minnesota students (n=325) were taught nutrition using traditional methods or IWBs. Significant increases in knowledge and behavior were observed in…

76 FR 38684 - Notice of Public Meeting for Proposed Withdrawal Extension; Colorado

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-01

...] Notice of Public Meeting for Proposed Withdrawal Extension; Colorado AGENCY: Bureau of Land Management... 2, 2011, in Pueblo, Colorado. The meeting will begin at 6 p.m. and adjourn at approximately 8 p.m... Sangre De Cristo Arts and Conference Center, 210 N. Santa Fe Ave., Pueblo, Colorado. FOR FURTHER...

Grasslands ecosystems, endangered species, and sustainable ranching in the Mexico-U.S. borderlands: Conference proceedings

Treesearch

Xavier Basurto; Diana Hadley

2006-01-01

The semi-arid grasslands in the Mexico-United States border region are relatively intact and provide one of the best opportunities in North America to preserve and nurture an extensive series of grassland ecosystems. The conference was organized to increase appreciation for the importance of the remaining semi-arid grasslands and to create a platform for expanding the...

Health Professions Education Extension Amendments of 1992. Conference Report, 2d Session. (To accompany H.R. 3508, 102d Congress, 2d Session.)

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House.

This conference report contains a proposed alternative amendment to the Public Health Service Act to reconcile differences between the Senate and House amendments. The bulk of the document presents the proposed revisions to: Title I on health professions education; Title II concerning nurse education; and Title III offering miscellaneous…

Quantifying Federal Funding and Scholarly Output Related to the Academic Emergency Medicine Consensus Conferences

PubMed Central

Nishijima, Daniel K.; Dinh, Tu; May, Larissa; Yadav, Kabir; Gaddis, Gary M.; Cone, David C.

2014-01-01

Purpose Since 2000, Academic Emergency Medicine (AEM), the journal of the Society for Academic Emergency Medicine, has presented a one-day consensus conference to generate a research agenda for advancement of a scientific topic. One of the 12 annual issues of AEM is reserved for the proceedings of these conferences. The purpose of this study was to measure academic productivity of these conferences by evaluating subsequent federal research funding received by authors of conference manuscripts and calculating citation counts of conference papers. Method This was a cross-sectional study conducted during August and September 2012. NIH RePORTER was searched to identify subsequent federal funding obtained by authors of the consensus conference issues from 2000 to 2010. Funded projects were coded as related or unrelated to conference topic. Citation counts for all conference manuscripts were quantified using Scopus and Google Scholar. Simple descriptive statistics were reported. Results 852 individual authors contributed to 280 papers published in the 11 consensus conference issues. 137 authors (16%) obtained funding for 318 projects. A median of 22 topic-related projects per conference (range 10–97 projects) accounted for a median of $20,488,331 per conference (range $7,779,512–122,918,205). The average (±SD) number of citations per paper was 15.7 ±20.5 in Scopus and 23.7 ±32.6 in Google Scholar. Conclusions The authors of consensus conference manuscripts obtained significant federal grant support for follow-up research related to conference themes. In addition, the manuscripts generated by these conferences were frequently cited. Conferences devoted to research agenda development appear to be an academically worthwhile endeavor. PMID:24280853

High-definition reconstruction of clonal composition in cancer.

PubMed

Fischer, Andrej; Vázquez-García, Ignacio; Illingworth, Christopher J R; Mustonen, Ville

2014-06-12

The extensive genetic heterogeneity of cancers can greatly affect therapy success due to the existence of subclonal mutations conferring resistance. However, the characterization of subclones in mixed-cell populations is computationally challenging due to the short length of sequence reads that are generated by current sequencing technologies. Here, we report cloneHD, a probabilistic algorithm for the performance of subclone reconstruction from data generated by high-throughput DNA sequencing: read depth, B-allele counts at germline heterozygous loci, and somatic mutation counts. The algorithm can exploit the added information present in correlated longitudinal or multiregion samples and takes into account correlations along genomes caused by events such as copy-number changes. We apply cloneHD to two case studies: a breast cancer sample and time-resolved samples of chronic lymphocytic leukemia, where we demonstrate that monitoring the response of a patient to therapy regimens is feasible. Our work provides new opportunities for tracking cancer development. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

The social media revolution is changing the conference experience: analytics and trends from eight international meetings.

PubMed

Wilkinson, Sarah E; Basto, Marnique Y; Perovic, Greta; Lawrentschuk, Nathan; Murphy, Declan G

2015-05-01

To analyse the use of Twitter at urology conferences to enhance the social media conference experience. We prospectively registered the hashtags of eight international urology conferences taking place in 2013, using the social media metrics website, Symplur.com. In addition, we prospectively registered the hashtag for the European Association of Urology (EAU) Annual Congress for 3 consecutive years (2012-2014) to analyse the trend in the use of Twitter at a particular meeting. Metrics including number of 'tweets', number of participants, tweet traffic per day, and overall digital impressions, which were captured for 5 days before each conference, the conference itself, and the following 2 days. We also measured corresponding social media activity at a very large non-urology meeting (the American Society of Clinical Oncology) for comparative purposes. Twitter activity was noted at all eight conferences in 2013. In all, 12,363 tweets were sent generating over 14 million impressions. The number of participants tweeting at each meeting varied from 80 (Congress of the Société Internationale d'Urologie, #SIU2013) to 573 (the American Urological Association, #AUA13). Overall, the AUA meeting (#AUA13) generated the most Twitter activity with >8.6 million impressions and a total of 4663 tweets over the peri-conference period. It also had the most impressions and tweets per day over this period, at 717,000 and 389, respectively. The EAU Annual Congress 2013 (#EAU13) generated 1.74 million impressions from a total of 1762 tweets from 236 participants. For trends in Twitter use, there was a very sharp rise in Twitter activity at the EAU Annual Congress between 2012 and 2014. Over this 3-year period, the number of participants increased almost 10-fold, leading to an increase in the number of tweets from 347 to almost 6000. At #EAU14, digital impressions reached 7.35 million with 5903 tweets sent by 797 participants. Urological conferences, to a varying extent, have adopted social media as a means of amplifying the conference experience to a wider audience, generating international engagement and global reach. Twitter is a very powerful tool that amplifies the content of scientific meetings, and conference organisers should put in place strategies to capitalise on this. © 2014 The Authors. BJU International © 2014 BJU International.

EDITORIAL: Adaptive and Active Materials: Selected Papers from the ASME 2008 Conference on Smart Materials, Adaptive Structures and Intelligent Systems (SMASIS 08) (Maryland, USA, 28-30 October 2008) Adaptive and Active Materials: Selected Papers from the ASME 2008 Conference on Smart Materials, Adaptive Structures and Intelligent Systems (SMASIS 08) (Maryland, USA, 28-30 October 2008)

NASA Astrophysics Data System (ADS)

Lynch, Christopher

2009-10-01

The rapid development of the field of Smart Materials, Adaptive Structures, and Materials Systems led the Aerospace Division ASMS TC to launch the new annual SMASIS conference in 2008. The conference focuses on the multi-disciplinary challenges of developing new multifunctional materials and implementing them in advanced systems. The research spans length scales from nano-structured materials to civil, air, and space structures. The first conference consisted of six symposia, each focusing on a different research area. This special issue of Smart Materials and Structures summarizes some of the top research presented at the 2008 SMASIS conference in the materials-focused symposia. These symposia focused on the behavior and mechanics of active materials, on multifunctional materials, and on bio-inspired materials. The behavior and mechanics of active materials is an approach that combines observed material behavior with mechanism-based models that not only give insight into the observed behavior, but guide the development of new materials. This approach has been applied to shape memory metals and polymers, ferroelectrics, ferromagnetics, and recently to multiferroic materials, and has led to considerable improvements in our understanding of multi-field phenomena. Multifunctional materials are the next generation of active materials. These materials include structural, sensing, and actuation components integrated into a material system. A natural extension of multifunctional materials is a new class of bio-inspired materials. Bio-inspired materials range from detailed bio-mimicry of sensing and self healing materials to nano and microstructures that take advantage of features observed in biological systems. The Editors would like to express their sincere thanks to all of the authors for their contributions to this special issue on 'Adaptive and Active Materials' for Smart Materials and Structures. We convey our gratitude to all of the reviewers for their time and dedication. We thank IOP Publishing for their support and encouragement of this special issue and the staff for their special attention and timely response.

Laser driven plasmas based incoherent x-ray sources at PALS and ELI Beamlines (Conference Presentation)

NASA Astrophysics Data System (ADS)

Kozlová, Michaela

2017-05-01

We will present data on a various X-ray production schemes from laser driven plasmas at the PALS Research Center and discuss the plan for the ELI Beamlines project. One of the approaches, how to generate ultrashort pulses of incoherent X-ray radiation, is based on interaction of femtosecond laser pulses with solid or liquid targets. So-called K-alpha source depending on used targets emits in hard X-ray region from micrometric source size. The source exhibits sufficient spatial coherence to observe phase contrast. Detailed characterization of various sources including the x-ray spectrum and the x-ray average yield along with phase contrast images of test objects will be presented. Other method, known as laser wakefield electron acceleration (LWFA), can produce up to GeV electron beams emitting radiation in collimated beam with a femtosecnond pulse duration. This approach was theoretically and experimentally examined at the PALS Center. The parameters of the PALS Ti:S laser interaction were studied by extensive particle-in-cell simulations with radiation post-processors in order to evaluate the capabilities of our system in this field. The extensions of those methods at the ELI Beamlines facility will enable to generate either higher X-ray energies or higher repetition rate. The architecture of such sources and their considered applications will be proposed.

Tracking the follow-up of work in progress papers.

PubMed

Mubin, Omar; Arsalan, Mudassar; Al Mahmud, Abdullah

2018-01-01

Academic conferences offer numerous submission tracks to support the inclusion of a variety of researchers and topics. Work in progress papers are one such submission type where authors present preliminary results in a poster session. They have recently gained popularity in the area of Human Computer Interaction (HCI) as a relatively easier pathway to attending the conference due to their higher acceptance rate as compared to the main tracks. However, it is not clear if these work in progress papers are further extended or transitioned into more complete and thorough full papers or are simply one-off pieces of research. In order to answer this we explore self-citation patterns of four work in progress editions in two popular HCI conferences (CHI2010, CHI2011, HRI2010 and HRI2011). Our results show that almost 50% of the work in progress papers do not have any self-citations and approximately only half of the self-citations can be considered as true extensions of the original work in progress paper. Specific conferences dominate as the preferred venue where extensions of these work in progress papers are published. Furthermore, the rate of self-citations peaks in the immediate year after publication and gradually tails off. By tracing author publication records, we also delve into possible reasons of work in progress papers not being cited in follow up publications. In conclusion, we speculate on the main trends observed and what they may mean looking ahead for the work in progress track of premier HCI conferences.

Options for Families in the Face of Adversity. (Proceedings of the Family Study Conference, Oklahoma State University, March 16-18, 1977).

ERIC Educational Resources Information Center

Oklahoma State Univ., Stillwater. Div. of Home Economics.

This report of a statewide conference on the possible options for families in the face of adversity was co-sponsored by the Family Study Center--Division of Home Economics, and the Office of University Extension, Oklahoma State University. General sessions on the effect of social change on the family, the co-relation between the energy crisis and…

The Computer: Extension of the Human Mind III. Proceedings of the Annual Summer Computer Conference (3rd, Eugene, Oregon, August 1-3, 1984).

ERIC Educational Resources Information Center

Oregon Univ., Eugene. Center for Advanced Technology in Education.

The 13 conference presentations in this proceedings are arranged by general and special interest sessions and listed within each session in the order in which they were presented. These papers are: (1) "Key Issues for the Near Future" (David Moursund); (2) "Educating with Computers: Insights from Cognitive Psychology (and Video Games)" (Morton Ann…

Alternative Designs for Evaluating Workplace Literacy Programs. Conference Proceedings and Commissioned Papers at the "Design Guidance for Evaluating Workplace Literacy Programs" Work Group Conference (Washington, D.C. April 13, 1993).

ERIC Educational Resources Information Center

Research Triangle Inst., Research Triangle Park, NC.

This document contains the five papers presented at a meeting at which key issues in evaluating workplace literacy programs were discussed. In "Key Components of Workplace Liteacy Projects and Definitions of Project 'Modules,'" Judith A. Alamprese describes the context for evaluating the National Extension Program, components of workplace literacy…

Linking Research and Practice: The NCTM Research Agenda Conference Report

ERIC Educational Resources Information Center

Arbaugh, Fran; Herbel-Eisenmann, Beth; Ramirez, Nora; Knuth, Eric; Kranendonk, Henry; Quander, Judith Reed

2010-01-01

In August 2008, the National Council of Teachers of Mathematics (NCTM) brought together approximately 60 mathematics education researchers and practitioners for a 4-day working conference. During this working conference, the participants analyzed over 350 mathematics education practitioner-generated questions in seven areas: assessment,…

The Generation in Between: A Perspective from the Keystone IV Conference.

PubMed

Chen, Frederick M; Bliss, Erika; Dunn, Aaron; Edgoose, Jennifer; Elliott, Tricia C; Maxwell, Lisa C; Morris, Carl G; Phillips, Robert L

2016-01-01

Keystone IV affirmed the value of relationships in family medicine, but each generation of family physicians took away different impressions and lessons. "Generation III," between the Baby Boomers and Millennials, reported conflict between their professional ideal of family medicine and the realities of current practice. But the Keystone conference also helped them appreciate core values of family medicine, their shared experience, and new opportunities for leadership. © Copyright 2016 by the American Board of Family Medicine.

Non-Relative Value Unit-Generating Activities Represent One-Fifth of Academic Neuroradiologist Productivity.

PubMed

Wintermark, M; Zeineh, M; Zaharchuk, G; Srivastava, A; Fischbein, N

2016-07-01

A neuroradiologist's activity includes many tasks beyond interpreting relative value unit-generating imaging studies. Our aim was to test a simple method to record and quantify the non-relative value unit-generating clinical activity represented by consults and clinical conferences, including tumor boards. Four full-time neuroradiologists, working an average of 50% clinical and 50% academic activity, systematically recorded all the non-relative value unit-generating consults and conferences in which they were involved during 3 months by using a simple, Web-based, computer-based application accessible from smartphones, tablets, or computers. The number and type of imaging studies they interpreted during the same period and the associated relative value units were extracted from our billing system. During 3 months, the 4 neuroradiologists working an average of 50% clinical activity interpreted 4241 relative value unit-generating imaging studies, representing 8152 work relative value units. During the same period, they recorded 792 non-relative value unit-generating study reviews as part of consults and conferences (not including reading room consults), representing 19% of the interpreted relative value unit-generating imaging studies. We propose a simple Web-based smartphone app to record and quantify non-relative value unit-generating activities including consults, clinical conferences, and tumor boards. The quantification of non-relative value unit-generating activities is paramount in this time of a paradigm shift from volume to value. It also represents an important tool for determining staffing levels, which cannot be performed on the basis of relative value unit only, considering the importance of time spent by radiologists on non-relative value unit-generating activities. It may also influence payment models from medical centers to radiology departments or practices. © 2016 by American Journal of Neuroradiology.

Community Concerns and Extension Youth Programs. Proceedings Regional Conference (February 18-20, 1981). Publication 28.

ERIC Educational Resources Information Center

White, Leigh Cree, Ed.

The 4-H/Community Resource Development workshop was designed to help people conducting Extension 4-H programs on sensitive and complex community issues improve their ability to create a better climate for discussion of alternatives and development of community projects. Topics of the presentations included the role of the 4-H administrator,…

76 FR 9399 - ITS Joint Program Office; Pre-Proposal Safety Pilot Joint Bidders Conference; Notice of Public...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-17

... Conference; Notice of Public Meeting AGENCY: Research and Innovative Technology Administration, U.S... Rhode Island Avenue, NW., Washington, DC 20036. The conference is for interested parties to learn about... systems. The model deployment data generated will be used for establishing safety benefits in support of...

A Decade of Graduate Climate Conferences for Training the Next Generation of Earth Scientists

NASA Astrophysics Data System (ADS)

Rosengard, S.; Rothenberg, D. A.; Lapo, K. E.; Johnson, L.; Rohr, T.; Perez-Betancourt, D.

2015-12-01

Since 2006, the Graduate Climate Conference (GCC) has served as a unique forum for students from diverse fields (both in physical/life and social sciences) to share innovative research relating to the climate system and global change. Organized exclusively by graduate students for graduate students, the conference provides a nurturing environment for attendees to familiarize themselves with the bleeding-edge in climate research, foster scientific connections between and across fields, and initiate new interdisciplinary collaborations. Moreover, the conference's single session format both ensures full exposure to the range of work being presented and provides presenters with a large and engaged audience. Here, we will both elucidate the history and objectives of the conference in addition to showcasing its impact on the younger generation within the climate science community via data and feedback collected from almost a decade of past participants. We will present results quantifying both the high scientific merit of the conference (i.e statistics on the amount of presented work that matriculated into peer reviewed publication, etc.) and the critical opportunity for professional development it provides (i.e. how many students gave their first serious scientific talk at the GCC, what sort professional collaborations developed at the GCC, post-doc fellowships and assistant professorships obtained by participants, etc.). The goal of this work is to illustrate how effective the GCC has been at connecting, educating, and nurturing the future generations of researchers from an extremely diverse set of backgrounds and to share with the community a successful model for future conferences both in the geosciences and the broader scientific community.

Generating political will for safe motherhood in Indonesia.

PubMed

Shiffman, Jeremy

2003-03-01

In 1987 an international conference brought global attention to an issue that previously had been ignored: the world's alarmingly high number of maternal deaths in childbirth. The conference ended with a declaration calling for a reduction in maternal mortality by at least half by the year 2000. As the deadline approached, safe motherhood activists lamented the fact that the world was nowhere near to achieving this objective. They attributed this failure to a variety of causes, but were in agreement that the medical technology was available to prevent maternal deaths in childbirth, and the key was generating the political will to make such technology widely available to women in developing countries.What 'political will' means, however, has been left as an unopened black box. What causes governments to give priority to the issue of safe motherhood, given that national political systems are burdened with thousands of issues to sort through each year? In marked contrast to our extensive knowledge about the medical interventions necessary to prevent maternal death, we know little about the political interventions necessary to increase the likelihood that national leaders pay meaningful attention to the issue. Drawing from a scholarly literature on agenda setting, this paper identifies four factors that heighten the likelihood that an issue will rise to national-level attention: the existence of clear indicators showing that a problem exists; the presence of effective political entrepreneurs to push the cause; the organization of attention-generating focusing events that promote widespread concern for the issue; and the availability of politically palatable policy alternatives that enable national leaders to understand that the problem is surmountable. The paper presents a case study of the emergence, waning and re-generation of political priority for safe motherhood in Indonesia over the decade 1987-1997, to highlight how these four factors interacted to raise safe motherhood from near obscurity in the country to national-level prominence. While there are contextual factors that make this case unique, some elements are applicable to all developing countries. The paper draws out these dimensions in the hope that greater knowledge surrounding how political will actually has been generated can help shape strategic action to address this much neglected global problem.

Introduction, Development and Extension of Compulsory Education. Conference Papers for the 8th Session of the International Standing Conference for the History of Education (Parma, Italy, September 3-6, 1986). Volume I.

ERIC Educational Resources Information Center

Genovesi, Giovanni, Ed.

This first of four volumes on the history of compulsory education among the nations of Europe and the Western hemisphere deals with historical antecedents and early development. Of the 29 total articles, 18 are in English and 2 have English summaries. Many selections include bibliographies. Titles and authors are as follows: "The Political…

SPINDEX Users Conference. Proceedings of a Meeting Held at Cornell University (Ithaca, New York, March 31 and April 1, 1978).

ERIC Educational Resources Information Center

Hickerson, H. Thomas, Ed.

These conference proceedings contain 21 papers presented by users of the Selective Permutation Indexing (SPINDEX) system, designed by the National Archives to produce a variety of computer-generated bibliographic aids for archival holdings. Institutions participating in the SPINDEX users' conference represented government, church, university,…

2nd Generation Reusable Launch Vehicle Potential Commercial Development Scenarios

NASA Technical Reports Server (NTRS)

Creech, Stephen D.; Rogacki, John R. (Technical Monitor)

2001-01-01

The presentation will discuss potential commercial development scenarios for a Second Generation Reusable Launch Vehicle. The analysis of potential scenarios will include commercial rates of return, government return on investment, and market considerations. The presentation will include policy considerations in addition to analysis of Second Generation Reusable Launch Vehicle economics. The data discussed is being developed as a part of NASA's Second Generation Reusable Launch Vehicle Program, for consideration as potential scenarios for enabling a next generation system. Material will include potential scenarios not previously considered by NASA or presented at other conferences. Candidate paper has not been presented at a previous meeting, and conference attendance of the author has been approved by NASA.

Establishing effective working relations with a potential user community - NASA Lewis Research Center experience

NASA Technical Reports Server (NTRS)

Foster, P.

1977-01-01

The NASA Lewis Research Center has held a series of six major and unique technology utilization conferences which were major milestones in planned structured efforts to establish effective working relationships with specific technology user communities. These efforts were unique in that the activities undertaken prior to the conference were extensive, and effectively laid the groundwork for productive technology transfer following, and as a direct result of, the conferences. The effort leading to the conference was in each case tailored to the characteristics of the potential user community, however, the common factors comprise a basic framework applicable to similar endeavors. The process is essentially a planned sequence of steps that constitute a technical market survey and a marketing program for the development of beneficial applications of aerospace technology beyond the aerospace field.

Twitter expands the reach and engagement of a national scientific meeting: the Irish Society of Urology.

PubMed

Nason, G J; O'Kelly, F; Bouchier-Hayes, D; Quinlan, D M; Manecksha, R P

2015-09-01

Social media is the interaction among people in which they create, share or exchange information and ideas in virtual communities and web-based networks. This year, the Irish Society of Urology (ISU) expanded its involvement in social media with a preregistered Twitter hashtag (#ISU14) for the annual meeting. The aim of this study was to highlight the use of Twitter at an annual national meeting held in 2014. The Symplur healthcare analytics website was used to prospectively examine traffic related to the 2014 ISU Annual Meeting. This feature was used to generate statistics for the number of impressions, unique tweets (excluding retweets) and distinct contributors who used the indexing hashtag #ISU14. Individual tweets were assessed using the conference hashtag on the Twitter website. The total number of attendees at the conference was 119, and 99 individuals participated in Twitter using the conference hashtag (#ISU14). 31 % of attendees participated in tweeting at the conference. Over the course of the conference, a total of 798 unique tweets were generated, creating over 665,000 impressions in cyberspace. 590 (73.9 %) tweets were generated from attendees at the conference, while 26.1 % of tweets were from virtual followers. 702 (87.9 %) tweets were from urologists and 439 (55 %) tweets were of scientific nature. Tweet activity peaked during the guest lectures on both days. Twitter use at the ISU has been shown to facilitate interaction between delegates and allows users to follow as well as participate from afar.

2009 Gordon Research Conference, Applied and Environmental Microbiology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dubilier, Nicole

The topic of the 2009 Gordon Conference on Applied and Environmental Microbiology is: From Single Cells to the Environment. The Conference will present and discuss cutting-edge research on applied and environmental microbiology with a focus on understanding interactions between microorganisms and the environment at levels ranging from single cells to complex communities. The Conference will feature a wide range of topics such as single cell techniques (including genomics, imaging, and NanoSIMS), microbial diversity at scales ranging from clonal to global, environmental 'meta-omics', biodegradation and bioremediation, metal - microbe interactions, animal microbiomes and symbioses. The Conference will bring together investigators whomore » are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Some poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with extensive discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an ideal setting for scientists from different disciplines to exchange ideas, brainstorm and discuss cross-disciplinary collaborations.« less

NSI conference support

NASA Technical Reports Server (NTRS)

Aaron, Susan

1991-01-01

One of the many services NSI provides as an extension of customer/user support is to attend major scientific conferences. The conference effort provides NASA/OSSA scientists with many benefits: (1) scientist get to see NSI in action; they utilize the network to read email, and have recently begun to demonstrate their scientific research to their colleagues; (2) scientist get an opportunity to meet and interact with NSI Staff, which gives scientists a chance to get status on their requirements, ask about network status, get acquainted with our procedures, and learn about services; and (3) scientists are exposed to networking in a larger sense; particularly by knowing about other NASA groups who provide valuable scientific resources over the Internet.

Boronline, a new generation of boron meter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pirat, P.

2011-07-01

Rolls-Royce is a global business providing integrated power systems for use on land, at sea and in the air. The Group has a balanced business portfolio with leading market positions - civil aerospace, defence aerospace, marine and energy Rolls-Royce understands the challenges of design, procurement, manufacture, operation and in-service support of nuclear reactor plants, with over 50 years of experience through the Royal Navy submarine programme. Rolls-Royce can therefore offer full product life-cycle management for new civil nuclear installations, as well as support to existing installations, including plant lifetime extensions. Rolls-Royce produced for 40 years, Instrumentation and Control (I andmore » C) systems of and associated services for nuclear reactors in Europe, including 58 French reactors and others situated in the United States and in others countries, such as China. Rolls-Royce equipped in this domain 200 nuclear reactors in 20 countries. Among all of its nuclear systems, Rolls Royce is presenting to the conference its new generation of on-line boron measurement system, so called Boronline. (authors)« less

75 FR 82387 - Next Generation Risk Assessment Public Dialogue Conference

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-30

... space. DATES: The conference will be held on February 15, 2011 from 8 a.m. to 5:30 p.m. and on February... knowledge about molecular system biology. This is the beginning of a process that will evolve over several... conference. Space is limited, and reservations will be accepted on a first-come, first-serve basis. For more...

The Imperative Educational Network: Parents, Teachers, and Concerned Individuals. Volume 4. Proceedings of the Imperative Educational Network Conference (Athens, Georgia, 1992).

ERIC Educational Resources Information Center

Tomlinson, Louise M., Ed.

This conference sought to provide a forum for the exchange of ideas on how parents, teachers, and other concerned individuals can contribute to strengthening the educational support system, and sought to generate practical information on strategies to improve achievement levels of youth. A conference program prospectus by Louise M. Tomlinson…

The Imperative Educational Network: Parents, Teachers, and Concerned Individuals. Volume 2. Proceedings of the Imperative Educational Network Conference (Athens, Georgia, 1990).

ERIC Educational Resources Information Center

Tomlinson, Louise M., Ed.

This conference was designed to provide a forum for the exchange of ideas on how parents, teachers, and other concerned individuals can contribute to strengthening the educational support system, and to generate practical information on strategies to improve achievement levels of youth. The first article, titled "Conference Program…

SHIFTING POLITICAL POWER IN THE UNITED STATES, IMPLICATIONS FOR EDUCATION IN AGRICULTURE. PAPER PRESENTED TO THE FEDERAL EXTENSION SERVICE ANNUAL STAFF CONFERENCE, JANUARY 10, 1967.

ERIC Educational Resources Information Center

HATHAWAY, DALE E.

THE RISE OF THE TWO PARTY SYSTEM IN THE SOUTH, REAPPORTIONMENT, AND POPULATION SHIFTS HAVE REMOVED THE SOUTH'S DOMINANCE IN AGRICULTURAL AFFAIRS AND INCREASED THE POWER OF THE LARGER COMMERCIALIZED FARMS OF THE WEST. EXTENSION PROGRAMS FOR THE RURAL POOR, WHO ARE LARGELY IN THE SOUTH, WILL FIND LITTLE SUPPORT FROM THE TRADITIONAL AGRICULTURAL…

A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan

PubMed Central

Kwan, Elizabeth X.; Foss, Eric J.; Tsuchiyama, Scott; Alvino, Gina M.; Kruglyak, Leonid; Kaeberlein, Matt; Raghuraman, M. K.; Brewer, Bonita J.; Kennedy, Brian K.; Bedalov, Antonio

2013-01-01

Aging and longevity are complex traits influenced by genetic and environmental factors. To identify quantitative trait loci (QTLs) that control replicative lifespan, we employed an outbred Saccharomyces cerevisiae model, generated by crossing a vineyard and a laboratory strain. The predominant QTL mapped to the rDNA, with the vineyard rDNA conferring a lifespan increase of 41%. The lifespan extension was independent of Sir2 and Fob1, but depended on a polymorphism in the rDNA origin of replication from the vineyard strain that reduced origin activation relative to the laboratory origin. Strains carrying vineyard rDNA origins have increased capacity for replication initiation at weak plasmid and genomic origins, suggesting that inability to complete genome replication presents a major impediment to replicative lifespan. Calorie restriction, a conserved mediator of lifespan extension that is also independent of Sir2 and Fob1, reduces rDNA origin firing in both laboratory and vineyard rDNA. Our results are consistent with the possibility that calorie restriction, similarly to the vineyard rDNA polymorphism, modulates replicative lifespan through control of rDNA origin activation, which in turn affects genome replication dynamics. PMID:23505383

A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan.

PubMed

Kwan, Elizabeth X; Foss, Eric J; Tsuchiyama, Scott; Alvino, Gina M; Kruglyak, Leonid; Kaeberlein, Matt; Raghuraman, M K; Brewer, Bonita J; Kennedy, Brian K; Bedalov, Antonio

2013-01-01

Aging and longevity are complex traits influenced by genetic and environmental factors. To identify quantitative trait loci (QTLs) that control replicative lifespan, we employed an outbred Saccharomyces cerevisiae model, generated by crossing a vineyard and a laboratory strain. The predominant QTL mapped to the rDNA, with the vineyard rDNA conferring a lifespan increase of 41%. The lifespan extension was independent of Sir2 and Fob1, but depended on a polymorphism in the rDNA origin of replication from the vineyard strain that reduced origin activation relative to the laboratory origin. Strains carrying vineyard rDNA origins have increased capacity for replication initiation at weak plasmid and genomic origins, suggesting that inability to complete genome replication presents a major impediment to replicative lifespan. Calorie restriction, a conserved mediator of lifespan extension that is also independent of Sir2 and Fob1, reduces rDNA origin firing in both laboratory and vineyard rDNA. Our results are consistent with the possibility that calorie restriction, similarly to the vineyard rDNA polymorphism, modulates replicative lifespan through control of rDNA origin activation, which in turn affects genome replication dynamics.

Incorporating climate change into corporate business strategies. Conference proceedings

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-12-31

This document contains the papers presented at the International Climate Change Conference and Technologies Exhibition June 12-13, 1997. Topics include energy supply and electricity generation; forestry and agriculture; and the chemical, energy, and manufacturing industries.

The Next Generation: Access and Opportunity in Continuing Higher Education. Proceedings of the Annual Meeting of the Association for Continuing Higher Education (70th, Nashville, Tennessee, November 8-11, 2008)

ERIC Educational Resources Information Center

Barrineau, Irene T., Ed.

2008-01-01

These proceedings record the 70th Annual Conference and Meeting of ACHE (Association for Continuing Higher Education) held at the Gaylord Opryland Resort and Convention Center in Nashville, Tennessee. The conference theme, "The Next Generation: Access and Opportunity in CHE" challenged attendees to think about the coming new age and its…

Chapman Conference on Generation of the Oceanic Lithosphere

NASA Astrophysics Data System (ADS)

Presnall, D. C.; Hales, A. L.; Frey, F. A.

On April 6-10, 1981, the Chapman conference on Generation of the Oceanic Lithosphere was held at Airlie House, Warrenton, Virginia. It was convened by D.C. Presnall, A.L. Hales (both at the University of Texas at Dallas), and F.A. Frey (Massachusetts Institute of Technology). The purpose of the conference was to bring together scientists with diverse specialties to develop a better understanding of the constraints imposed by geophysics, geochemistry, petrology, and tectonics on processes of oceanic lithosphere generation. Sessions were held on the nature of the crust and upper mantle at spreading centers; trace elements and isotopes; experimental petrology; magma chamber dynamics, melt migration, and mantle flow; slow versus fast spreading ridges; Atlantic spreading centers; Pacific spreading centers; and hydrothermal activity, metasomatism, and metamorphism. Fifty-four oral papers and 47 poster papers were presented. One hundred twenty-eight scientists attended from Australia, Canada, Cyprus, Denmark, France, Iceland, Japan, Mexico, United Kingdom, United States, and the USSR.

Next generation vaccines.

PubMed

Riedmann, Eva M

2011-07-01

In February this year, about 100 delegates gathered for three days in Vienna (Austria) for the Next Generation Vaccines conference. The meeting held in the Vienna Hilton Hotel from 23rd-25th February 2011 had a strong focus on biotech and industry. The conference organizer Jacob Fleming managed to put together a versatile program ranging from the future generation of vaccines to manufacturing, vaccine distribution and delivery, to regulatory and public health issues. Carefully selected top industry experts presented first-hand experience and shared solutions for overcoming the latest challenges in the field of vaccinology. The program also included several case study presentations on novel vaccine candidates in different stages of development. An interactive pre-conference workshop as well as interactive panel discussions during the meeting allowed all delegates to gain new knowledge and become involved in lively discussions on timely, interesting and sometimes controversial topics related to vaccines.

The Imperative Educational Network: Parents, Teachers, and Concerned Individuals. Volume 3. Proceedings of the Imperative Educational Network Conference (Athens, Georgia, 1991).

ERIC Educational Resources Information Center

Tomlinson, Louise M., Ed.

This conference sought to provide a forum for the exchange of ideas on how parents, teachers, and other concerned individuals can contribute to strengthening the educational support system, and to generate practical information on strategies to improve achievement levels of youth. A conference program prospectus by Louise M. Tomlinson offers a…

The Indian Child Welfare Act: Unto the Seventh Generation. Conference Proceedings (Los Angeles, California, January 15-17, 1992). National Conference Proceedings Series.

ERIC Educational Resources Information Center

Johnson, Troy R., Ed.

This proceedings contains edited transcripts of speeches and workshops given at a conference on the Indian Child Welfare Act (ICWA), held at UCLA in January 1992. Workshop titles were: fetal alcohol syndrome; responding to the family in Indian child welfare; joint in-service training for management of Indian Child Welfare Act cases; domestic…

Second Annual Conference on Astronomical Data Analysis Software and Systems. Abstracts

NASA Technical Reports Server (NTRS)

1992-01-01

Abstracts from the conference are presented. The topics covered include the following: next generation software systems and languages; databases, catalogs, and archives; user interfaces/visualization; real-time data acquisition/scheduling; and IRAF/STSDAS/PROS status reports.

Effective ways to communicate research using the poster format

USDA-ARS?s Scientific Manuscript database

Numerous academic conferences feature multiple venues for presentation of academic research results. While numerous associations provide conference presenters with potential best practices for the generation and presentation of information, not all presenters follow the suggested guidelines. This st...

Matching Extension and Connectivity in Graphs. 1. Introduction and Terminology,

DTIC Science & Technology

1986-01-01

minimal elementary bipartite graphs, J. Combin. Theory Ser. B 23, 1977, 127-138. 1986. Matching Theory, Ann. Discrete Math ., North-Holland, Amsterdam, 1986...to appear). M. D. PLUMMER 1980. On n-extendable graphs, Discrete Math . 31, 1980, 201-210. 1985. A theorem on matchings in the plane, Conference in...memory of Gabriel Dirac, Ann. Discrete Math ., North-Holland, Amsterdam, to appear. 1986a. Matching extension in bipartite graphs, preprint, 1986. 1986b

The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors

PubMed Central

Romano, Keith P.; Ali, Akbar; Aydin, Cihan; Soumana, Djade; Özen, Ayşegül; Deveau, Laura M.; Silver, Casey; Cao, Hong; Newton, Alicia; Petropoulos, Christos J.; Huang, Wei; Schiffer, Celia A.

2012-01-01

Hepatitis C virus (HCV) infects over 170 million people worldwide and is the leading cause of chronic liver diseases, including cirrhosis, liver failure, and liver cancer. Available antiviral therapies cause severe side effects and are effective only for a subset of patients, though treatment outcomes have recently been improved by the combination therapy now including boceprevir and telaprevir, which inhibit the viral NS3/4A protease. Despite extensive efforts to develop more potent next-generation protease inhibitors, however, the long-term efficacy of this drug class is challenged by the rapid emergence of resistance. Single-site mutations at protease residues R155, A156 and D168 confer resistance to nearly all inhibitors in clinical development. Thus, developing the next-generation of drugs that retain activity against a broader spectrum of resistant viral variants requires a comprehensive understanding of the molecular basis of drug resistance. In this study, 16 high-resolution crystal structures of four representative protease inhibitors – telaprevir, danoprevir, vaniprevir and MK-5172 – in complex with the wild-type protease and three major drug-resistant variants R155K, A156T and D168A, reveal unique molecular underpinnings of resistance to each drug. The drugs exhibit differential susceptibilities to these protease variants in both enzymatic and antiviral assays. Telaprevir, danoprevir and vaniprevir interact directly with sites that confer resistance upon mutation, while MK-5172 interacts in a unique conformation with the catalytic triad. This novel mode of MK-5172 binding explains its retained potency against two multi-drug-resistant variants, R155K and D168A. These findings define the molecular basis of HCV N3/4A protease inhibitor resistance and provide potential strategies for designing robust therapies against this rapidly evolving virus. PMID:22910833

Personality of Teacher in Advanced Socialist Society. Collection of Papers from the Conference of Educationalists of Socialist Countries (3rd, Warsaw, Poland, June 1977).

ERIC Educational Resources Information Center

Tmej, K., Ed.; Petracek, S., Ed.

A need for concerted efforts in devising a more profound socialist education for the younger generation, and a strengthening of ideological ties joining the socialist nations was revealed in conference papers on: (1) the conference's significance (K. Tmej); (2) inaugural address (J. Kuberski); (3) Marxism-Leninism on the task of schools and…

A view from Cheyenne Mountain: Generation III's perspective of Keystone III.

PubMed

Bliss, Erika; Cadwallader, Kara; Steyer, Terrence E; Clements, Deborah S; Devoe, Jennifer E; Fink, Kenneth; Khubesrian, Marina; Lyons, Paul; Steiner, Elizabeth; Weismiller, David

2014-01-01

In October 2000 the family of family medicine convened the Keystone III conference at Cheyenne Mountain Resort. Keystone III participants included members of Generation I (entered practice before 1970), Generation II (entered 1970-1990), and Generation III (entered after 1990). They represented a wide range of family physicians, from medical students to founders of the discipline, and from small-town solo practice to academic medicine. During the conference, the three generations worked together and separately thinking about the past, present, and future of family medicine, our roles in it, and how the understanding of a family physician and our discipline had and would continue to evolve. After the conference, the 10 Generation III members wrote the article published here, reflecting on our experiences as new physicians and physicians in training, and the similarities and differences between our experiences and those of physicians in Generations I and II. Key similarities included commitment to whole-person care, to a wide scope of practice, to community health, and to ongoing engagement with our discipline. Key differences included our understanding of availability, the need for work-life balance, the role of technology in the physician-patient relationship, and the perceptions of the relationship between medicine and a range of outside forces such as insurance and government. This article, presented with only minor edits, thus reflects accurately our perceptions in late 2000. The accompanying editorial reflects our current perspective.

WebWise 2.0: The Power of Community. WebWise Conference on Libraries and Museums in the Digital World Proceedings (9th, Miami Beach, Florida, March 5-7, 2008)

ERIC Educational Resources Information Center

Green, David

2009-01-01

Since it was coined by Tim O'Reilly in formulating the first Web 2.0 Conference in 2004, the term "Web 2.0" has definitely caught on as a designation of a second generation of Web design and experience that emphasizes a high degree of interaction with, and among, users. Rather than simply consulting and reading Web pages, the Web 2.0 generation is…

The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction.

PubMed

Rascón, Brenda; Hubbard, Basil P; Sinclair, David A; Amdam, Gro V

2012-07-01

Our interest in healthy aging and in evolutionarily conserved mechanisms of lifespan extension prompted us to investigate whether features of age-related decline in the honey bee could be attenuated with resveratrol. Resveratrol is regarded as a caloric restriction mimetic known to extend lifespan in some but not all model species. The current, prevailing view is that resveratrol works largely by activating signaling pathways. It has also been suggested that resveratrol may act as an antioxidant and confer protection against nervous system impairment and oxidative stress. To test whether honey bee lifespan, learning performance, and food perception could be altered by resveratrol, we supplemented the diets of honey bees and measured lifespan, olfactory learning, and gustatory responsiveness to sucrose. Furthermore, to test the effects of resveratrol under metabolic challenge, we used hyperoxic environments to generate oxidative stress. Under normal oxygen conditions, two resveratrol treatments-30 and 130 μM-lengthened average lifespan in wild-type honey bees by 38% and 33%, respectively. Both resveratrol treatments also lengthened maximum and median lifespan. In contrast, hyperoxic stress abolished the resveratrol life-extension response. Furthermore, resveratrol did not affect learning performance, but did alter gustation. Honey bees that were not fed resveratrol exhibited greater responsiveness to sugar, while those supplemented with resveratrol were less responsive to sugar. We also discovered that individuals fed a high dose of resveratrol-compared to controls-ingested fewer quantities of food under ad libitum feeding conditions.

10 CFR 710.25 - Appointment of Hearing Officer; prehearing conference; commencement of hearings.

Code of Federal Regulations, 2010 CFR

2010-01-01

... papers, issuing subpoenas for witnesses to attend the hearing or for the production of specific documents... extension of the hearing date past 90 calendar days from the date the request for hearing is received by the...

75 FR 82416 - Proposed Information Collection Renewals

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-30

...--Online Registration Form. OMB Control Number: 0420-0541. Type of Review: Regular--extension, without... and Budget (OMB) review; comment request. SUMMARY: The Peace Corps has submitted the following three... of three information collections: World Wise Schools Conference Online Registration Form (OMB 0420...

Proceedings of the Displaced Homemakers Conference.

ERIC Educational Resources Information Center

Illinois State Office of Education, Springfield. Div. of Adult Vocational and Technical Education.

The 1979 Displaced Homemakers Conference focused on developing awareness of services available from various Illinois agencies to displaced homemakers, generating the spirit and means for cooperative relationships among agencies serving them, and offering prototypes of how women's centers are attempting to coordinate the various services of state…

PREFACE: 15th International Conference on Photoacoustic and Photothermal Phenomena (ICPPP15)

NASA Astrophysics Data System (ADS)

Glorieux, Christ; Thoen, Jan

2010-01-01

Conference banner Although the roots of this scientific field go back to the end of the nineteenth century when A G Bell discovered the photoacoustic effect generated by the absorption of modulated light in a sample, major and rapid progress only occurred since the mid-1970's when the photoacoustic effect in condensed matter was put on a firm theoretical basis by A Rosencwaig and A Gersho. Since that time the fields of photoacoustics and the related fields of photothermal phenomena and laser ultrasonics have grown enormously. A multitude of ways of generating the effects has emerged using all kinds of radiation. Likewise, the diversity in methods for the detection of the generated thermal and acoustic waves has increased dramatically. One of the reasons for the popularity of the photoacoustic and photothermal field is the wide applicability of these techniques for fundamental and applied research. At this moment, the field has become really multidisciplinary and it is safe to say that it has reached a mature state with an established position in measurement technology and materials characterization. This conference as well as the ones before reflected this large diversity in the program topics and the research disciplines of the participants. This 15th International Conference on Photoacoustic and Photothermal Phenomena was held on a campus of the Catholic University of Leuven in Belgium in the week of 19-23 July 2009. During the conference 15 tutorial lectures, 8 plenary lectures, 36 invited talks, 120 oral and 172 poster communications were presented. The conference was attended by 252 participants from 38 countries from all over the world. During a special session award lectures were presented by winners of the prizes of the International Photoacoustic and Photothermal Association (IPPA). Winners of the senior prize were A Mandelis, D Fournier and A C Boccara. The winner of the junior prize was T W Murray. The editors of the proceedings of this conference believe that the published papers provide significant contributions to the field of photoacoustic and phothermal phenomena and can serve as a good introduction to scientists outside of the field. C Glorieux J Thoen Editors Conference photograph

Educational Impact of Trainee-Facilitated Head and Neck Radiology-Pathology Correlation Conferences.

PubMed

Ginat, Daniel Thomas; Cipriani, Nicole A; Christoforidis, Gregory

2018-05-17

The goal of this study was to evaluate the benefits of resident and fellow-facilitated radiology-pathology head and neck conferences. A total of seven resident-facilitated and six fellow-facilitated head and neck radiology-pathology cases were presented as part of the radiology department conference series. The radiology residents were surveyed regarding the perceived quality and effectiveness of the fellow-facilitated sessions. The number of publications yielded from all the cases presented was tracked. Overall, the residents assessed the quality of the fellow-facilitated conferences with an average score of 3.9 out of 5 and the overall helpfulness with an average of 3.5 out of 5. The overall average level of resident understanding among the residents for the topics presented to them by the fellows at baseline was 2.5 out of 5 and 3.4 out of 5 after the presentations, which was a significant increase (p-value < 0.01). There were three peer-reviewed publications generated from the resident presentations and four peer-reviewed publications generated from the fellow presentations, which represents a 54% publication rate collectively. Therefore, trainee-facilitated head and neck radiology-pathology conferences at our institution provide added learning and scholarly activity opportunities.

Integrating Gender into the Political Science Core Curriculum

ERIC Educational Resources Information Center

Cassese, Erin C.; Bos, Angela L.; Duncan, Lauren E.

2012-01-01

The New Research on Gender in Political Psychology Conference brought together new and experienced teachers with interests in gender politics. The conference session "Teaching Gender throughout the Curriculum" generated a great deal of discussion concerning the pedagogical practice of gender mainstreaming. Gender mainstreaming--the integration of…

ISAF Overview Brief

DTIC Science & Technology

2011-01-01

Eager Afghans NEW PA STUDENTS NATO / ISAF UNCLASSIFIED NATO / ISAF UNCLASSIFIED ISAF Overview Brief, MHS Conference 2011 – Attrition, Leader deficit...doctors (male/fem), 2 nurses, 2 midwives. 100k-300k XRAY, surgery, OB, physiotherapy , pediatrician, pharmacist, dentist. 10k-15k An extension of the BHC

Comparing Current Students to a Pre-Millennial Generation: Are They Really Different?

ERIC Educational Resources Information Center

Yahr, Michael A.; Schimmel, Kurt

2013-01-01

The Millennial generation, also known as Generation Y, has garnered much attention in the print and broadcast media and at academic conferences because of the challenges that they pose to universities and corporations. Aggregate characteristics and preferences of the Millennial generation and of Generation X, their immediate predecessors, have…

An impetus to move the field forward: a look at child and adolescent mental health services participants' views of the prospects for change.

PubMed

Haynes, Katherine Taylor

2010-03-01

In September 2009 key stakeholders convened for the invitation-only Child and Adolescent Mental Health Services (CAMHS): Issues and Solutions conference. This paper provides a brief synopsis of the key high points and issues in children's mental health (CMH) and describes the process by which participants collectively brainstormed the priorities and distilled the four key foci for the new action agenda, and summarizes the key outcomes. In addition, this paper offers participants' perspectives on the conference. Based on observation notes and post-conference qualitative interviews, this paper reports conference participants' feedback on the event, their views on the prospects for change generated by the conference and suggestions for follow-up.

A Monocular SLAM Method to Estimate Relative Pose During Satellite Proximity Operations

DTIC Science & Technology

2015-03-26

localization and mapping with efficient outlier handling. In The IEEE Conference on Computer Vision and Pattern Recognition (CVPR), June 2013. 5. Herbert Bay...S.H. Spencer . Next generation advanced video guidance sensor. In Aerospace Conference, 2008 IEEE, pages 1–8, March 2008. 12. Michael Calonder, Vincent

QoS Adaptation in Multimedia Multicast Conference Applications for E-Learning Services

ERIC Educational Resources Information Center

Deusdado, Sérgio; Carvalho, Paulo

2006-01-01

The evolution of the World Wide Web service has incorporated new distributed multimedia conference applications, powering a new generation of e-learning development and allowing improved interactivity and prohuman relations. Groupware applications are increasingly representative in the Internet home applications market, however, the Quality of…

Adolescent Health: A Generation at Risk.

ERIC Educational Resources Information Center

Hechinger, Fred M.

1994-01-01

A 3-day conference brought together health and education experts to explore responses to adolescent health problems and to suggest ways to implement the recommendations put forward in "Fateful Choices: Healthy Youth for the 21st Century," by Fred M. Hechinger. Conference participants identified a number of adolescent health problems and the areas…

Future Directions for the National Health Accounts

PubMed Central

Huskamp, Haiden A.; Newhouse, Joseph P.

1999-01-01

Over the past 15 years, the Health Care Financing Administration (HCFA) has engaged in ongoing efforts to improve the methodology and data collection processes used to develop the national health accounts (NHA) estimates of national health expenditures (NHE). In March 1998, HCFA initiated a third conference to explore possible improvements or useful extensions to the current NHA projects. This article summarizes the issues discussed at the conference, provides an overview of three commissioned papers on future directions for the NHA that were presented, and summarizes suggestions made by participants regarding future directions for the accounts. PMID:11481786

Proceedings of the American Power Conference. Volume 58-II

DOE Office of Scientific and Technical Information (OSTI.GOV)

McBride, A.E.

1996-11-01

This book is part 2 of the proceedings of the American Power Conference, Technology for Competition and Globalization, 1996. The topics of the papers include structural plant design; challenges of the global marketplace; thermal hydraulic methods for nuclear power plant safety and operation; decontamination and decommissioning; competitive operations and maintenance; fuel opportunities; cooling; competitive power pricing; operations; transformers; relays; plant controls; training to meet the competitive future; burning technologies; ash and byproducts utilization; advanced systems; computer tools for plant design; globalization of power; power system protection and power quality; life extension; grounding; and transmission line equipment.

Polar Gateways Arctic Circle Sunrise Conference 2008, Barrow, Alaska: IHY-IPY Outreach on Exploration of Polar and Icy Worlds in The Solar System

NASA Astrophysics Data System (ADS)

Cooper, John F.; Kauristie, K.; Weatherwax, A. T.; Sheehan, G. W.; Smith, R. W.; Sandahl, I.; Østgaard, N.; Chernouss, S.; Moore, M. H.; Peticolas, L. M.; Senske, D. A.; Thompson, B. J.; Tamppari, L. K.; Lewis, E. M.

2008-09-01

Polar, heliophysical, and planetary science topics related to the International Heliophysical and Polar Years 2007-2009 were addressed during this circumpolar video conference hosted January 23-29, 2008 at the new Barrow Arctic Research Center of the Barrow Arctic Science Consortium in Barrow, Alaska. This conference was planned as an IHY-IPY event science outreach event bringing together scientists and educational specialists for the first week of sunrise at subzero Arctic temperatures in Barrow. Science presentations spanned the solar system from the polar Sun to Earth, Moon, Mars, Jupiter, Saturn, and the Kuiper Belt. On-site participants experienced look and feel of icy worlds like Europa and Titan by being in the Barrow tundra and sea ice environment and by going "on the ice" during snowmobile expeditions to the near-shore sea ice environment and to Point Barrow, closest geographic point in the U.S. to the North Pole. Many science presentations were made remotely via video conference or teleconference from Sweden, Norway, Russia, Canada, Antarctica, and the United States, spanning up to thirteen time zones (Alaska to Russia) at various times. Extensive educational outreach activities were conducted with the local Barrow and Alaska North Slope communities and through the NASA Digital Learning Network live from the "top of the world" at Barrow. The Sun-Earth Day team from Goddard, and a videographer from the Passport to Knowledge project, carried out extensive educational interviews with many participants and native Inupiaq Eskimo residents of Barrow. Video and podcast recordings of selected interviews are available at http://sunearthday.nasa.gov/2008/multimedia/podcasts.php. Excerpts from these and other interviews will be included in a new high definition video documentary called "From the Sun to the Stars: The New Science of Heliophysics" from Passport to Knowledge that will later broadcast on NASA TV and other educational networks. Full conference proceedings are accessible at http://polargateways2008.org/.

Polar Gateways Arctic Circle Sunrise Conference 2008, Barrow, Alaska: IHY-IPY Outreach on Exploration of Polar and Icy Worlds in the Solar System

NASA Technical Reports Server (NTRS)

Cooper, John F.; Kauristie, Kirsti; Weatherwax, Allan T.; Sheehan, Glenn W.; Smith, Roger W.; Sandahl, Ingrid; Ostgaard, Nikolai; Chernouss, Sergey; Thompson, Barbara J.; Peticolas, Laura;

Programs and Registrations (ACHE-NUEA), 1975-76.

ERIC Educational Resources Information Center

Barton, William D.; And Others

This annual report (1975-76) presents responses from 258 higher education institutions on the trends in continuing education registration in classes, conference programs, and independent study. (The institutions responding carried membership in the Association for Continuing Higher Education and the National University Extension Association.) The…

Grower Communication Networks: Information Sources for Organic Farmers

ERIC Educational Resources Information Center

Crawford, Chelsi; Grossman, Julie; Warren, Sarah T.; Cubbage, Fred

2015-01-01

This article reports on a study to determine which information sources organic growers use to inform farming practices by conducting in-depth semi-structured interviews with 23 organic farmers across 17 North Carolina counties. Effective information sources included: networking, agricultural organizations, universities, conferences, Extension, Web…

76 FR 51364 - Notification of a Public Teleconference of the Science Advisory Board Panel for the Review of the...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-18

... extensive scientific studies, conferences and workshops. To guide the efforts of the GLRI, EPA and its... Web site at http://www.epa.gov/sab in advance of the meeting. Procedures for Providing Public Input...

Water Chemistry and Chemistry Monitoring at Thermal and Nuclear Power Plants: Problems and Tasks (Based on Proceedings of Conferences)

NASA Astrophysics Data System (ADS)

Larin, B. M.

2018-02-01

In late May-early June 2017, two international science and technology conferences on problems of water chemistry and chemistry monitoring at thermal and nuclear power plants were held. The participants of both the first conference held at OAO VTI and the second conference that took place at NITI formulated the problems of the development of the regulatory base and implementation of promising water treatment technologies and outlined the ways of improving the water chemistry and chemistry monitoring at TPPs and NPPs for the near future. It was pointed out that the new amine-containing VTIAMIN agent developed by OAO VTI had been successfully tested on the power-generating units equipped with steam-gas plants to establish the minimum excess of the film-forming amine in the power-generating unit circuit that ensures the protection of the metal as 5-10 μg/dm3. A flow-injection technique for the analysis of trace concentrations of chlorides was proposed; the technique applied to the condensate of the 1000-MW steam turbine of the NPP power-generating unit yields the results comparable with the results obtained by the ion chromatography and the potentiometric method using the solver electrode. The participants of the conferences were demonstrated new Russian instruments to analyze the water media at the TPPs and NPPs, including the total organic carbon analyzer and the analyzer of mineral impurities in the condensate and feed water, that won a gold medal at the 45th International Exhibition of Inventions held in Geneva this April.

Parallel computational fluid dynamics '91; Conference Proceedings, Stuttgart, Germany, Jun. 10-12, 1991

NASA Technical Reports Server (NTRS)

Reinsch, K. G. (Editor); Schmidt, W. (Editor); Ecer, A. (Editor); Haeuser, Jochem (Editor); Periaux, J. (Editor)

1992-01-01

A conference was held on parallel computational fluid dynamics and produced related papers. Topics discussed in these papers include: parallel implicit and explicit solvers for compressible flow, parallel computational techniques for Euler and Navier-Stokes equations, grid generation techniques for parallel computers, and aerodynamic simulation om massively parallel systems.

Airborne Wind Shear Detection and Warning Systems: Third Combined Manufacturers' and Technologists' Conference, part 1

NASA Technical Reports Server (NTRS)

Vicroy, Dan D. (Compiler); Bowles, Roland L. (Compiler); Schlickenmaier, Herbert (Compiler)

1991-01-01

Papers presented at the conference on airborne wind shear detection and warning systems are compiled. The following subject areas are covered: terms of reference; case study; flight management; sensor fusion and flight evaluation; Terminal Doppler Weather Radar data link/display; heavy rain aerodynamics; and second generation reactive systems.

Automating Physical Database Design: An Extensible Approach

DTIC Science & Technology

1993-03-01

Schonberg. Tom Cheatham of Harvard University and Software Options provided much encouragement and support, as did Glenn Holloway, Judy Townley , and Mike...through- out, and also helped by reading drafts of a conference paper that reported earlier stages of this work (as did Glenn Holloway and Judy Townley

MAP-21

THOMAS, 112th Congress

Rep. Mica, John L. [R-FL-7

2012-04-16

07/06/2012 Became Public Law No: 112-141. (TXT | PDF) (All Actions) Notes: Division F of the conference report includes Flood Insurance Reform and Modernization (Title II) and Student Loan Interest Rate Extension (Title III). Tracker: This bill has the status Became LawHere are the steps for Status of Legislation:

Social Studies. [SITE 2001 Section].

ERIC Educational Resources Information Center

White, Cameron, Ed.

This document contains the following papers on social studies from the SITE (Society for Information Technology & Teacher Education) 2001 conference: (1) "Teacher's Guide to the Holocaust: An Extensive Online Resource for Teachers" (Ann E. Barron and others); (2) "Preparing a Virtual Field Trip To Teach Value of Community and…

Payment Services for Global Online Systems Including Internet.

ERIC Educational Resources Information Center

Seebeck, Bill; And Others

1995-01-01

A panel of four conference presenters address issues related to paying for services provided through online systems. Discussion includes the following topics: metering devices; electronic/digital cash; working within existing banking/credit card structures; provision of payment mechanisms in countries without extensive credit card usage; and…

PREFACE: 14th International Conference on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2014)

NASA Astrophysics Data System (ADS)

2014-11-01

It is our great pleasure to welcome you to the 14th International Conference on Micro- and Nano-Technology for Power Generation and Energy Conversion Applications, or PowerMEMS 2014, in Awaji Island, Japan. The aim of PowerMEM is to present the latest research results in the field of miniature, micro- and nano-scale technologies for power generation and energy conversion. The conference will also- give us the opportunity to exchange informations and new ideas in the field of Power MEMS/NEMS. The current status of the field of PowerMEMS spans the full spectrum from basic research to practical applications. We will enjoy valuable discussions not only from the viewpoint of academia but from commercial and industrial perspectives. In the conference, three invited speakers lead the technical program. We received 172 abstracts and after a careful reviewing process by the Technical Program Committee a total of 133 papers were selected for presentation. These have been organized into 16 Oral sessions in two parallel streams and two poster sessions including some late-news papers. The oral and regular poster papers are published by the Institute of Physics (IOP). We have also organized a PowerMEMS School in Kobe-Sannomiya contiguous to the main conference. This two-day school will cover various topics of energy harvesting. World leading experts will give invited lectures on their main topics. This is a new experiment to broaden the technology remit of our conference by organizing mini symposiums that aim to gather the latest research on the following topics by the organizers: Microscale Combustion, Wideband Vibration Energy Harvesting, RF Energy Transfer and Industrial Application. We hope this, and other activities will make PowerMEMS2014 a memorable success. One of the important programs in an international conference is the social program, and we prepare the PowerMEMS2014 banquet in the banquet room at the Westin Awaji Island Hotel. This will provide an opportunity to create strong networks between researchers. We also provide nice opportunities to experience Japanese nature and culture. The special cruise to see the magnificent whirlpool up close will definitely be one of the highlights. Additionally, we will serve Awaji's traditional performing art, Awaji Ningyo Joruri, which has a history of over 500 years and has been inherited through the generations. There are many individuals we would like to thank for their support in organizing PowerMEMS2014. The TPC, chaired by Takayuki Fujita, have given us their valuable time and best effort in reviewing abstracts. The PowerMEMS School chair Yuji Suzuki and the expert speakers made the School possible. The local organizing committee, led by Kensuke Kanda has provided us with invaluable assistance in preparing the PowerMEMS2014 venue. The financial support from both the Tsutomu Nakauchi Foundation, the Hyogo International Association and the conference sponsors have also been gratefully appreciated. Finally, we would like to thank each of you for attending the conference and bringing your expertise. We wish you all a successful conference and an exciting and relaxing stay in Awaji Island.

Increasing Understanding of Public Problems and Policies, 1995.

ERIC Educational Resources Information Center

Halbrook, Steve A., Ed.; Merry, Carroll E., Ed.

This document contains abstracts and the complete texts of 19 papers that were presented at a conference held to improve the policy education efforts of extension workers responsible for public affairs programs. The following papers are included: "Microwave Society and Crock-Pot Government" (Bill Graves); "Citizen Participation,…

The School and the Democratic Environment.

ERIC Educational Resources Information Center

1970

The purpose of the conference was to explore how schools can prepare students to function in a democratic society beset by unprededented demands, complexities, and inconsistencies between theory and practice. Educational reform was the long-range goal, the short-term goal being the extension of dialogue in large and small school districts leading…

Abstract for 1999 Rational Software User Conference

NASA Technical Reports Server (NTRS)

Dunphy, Julia; Rouquette, Nicolas; Feather, Martin; Tung, Yu-Wen

1999-01-01

We develop spacecraft fault-protection software at NASA/JPL. Challenges exemplified by our task: 1) high-quality systems - need for extensive validation & verification; 2) multi-disciplinary context - involves experts from diverse areas; 3) embedded systems - must adapt to external practices, notations, etc.; and 4) development pressures - NASA's mandate of "better, faster, cheaper".

Searchers Net Treasure in Monterey.

ERIC Educational Resources Information Center

McDermott, Irene E.

1999-01-01

Reports on Web keyword searching, metadata, Dublin Core, Extensible Markup Language (XML), metasearch engines (metasearch engines search several Web indexes and/or directories and/or Usenet and/or specific Web sites), and the Year 2000 (Y2K) dilemma, all topics discussed at the second annual Internet Librarian Conference sponsored by Information…

Enhancements and Extensions of Formal Models for Risk Assessment in Software Projects

DTIC Science & Technology

2002-09-01

the five defect categories. Cosmetic Defects. The name that corresponds to QSM®’s cosmetic defects. Cosmetic defects can be described as deferred...California. June 2002. (Fent00) Fenton , N. E. and Neil, M., Software Metrics: Roadmap. Proceedings of the Conference on the Future of Software

Produce Your Own: A Community Gardening Program

ERIC Educational Resources Information Center

Miller, JoLynn; Arnold, Shannon

2012-01-01

Many County Extension offices offer an adult Master Gardener Program, which includes advanced gardening training, short courses, newsletters, and conferences. However, with the comprehensive training provided comes a large time commitment. The Produce Your Own program was created to introduce adults to gardening in a similar manner, but with…

Proceedings of the American Power Conference. Volume 60-1

DOE Office of Scientific and Technical Information (OSTI.GOV)

McBride, A.E.

1998-12-01

The American Power Conference, 60th annual meeting, 1998, addressed reliability and economy as related to technology for competition and globalization. The topics of the papers included needs and advances in power engineering education, global climate change, distributed generation, the critical role of the nations largest coal, nuclear and hydropower stations, advances in generation technology, financing electric power projects, successful deregulation, year 2000 outlook for equipment conflict with information and control, system planning, asset management, relay and communication, particulate and SO{sub x} control, environmental protection compliance strategies, fuel cells, gas turbines, renewable energy, steam turbines, and cost reduction strategies.

Proceedings of the American Power Conference. Volume 60-2

DOE Office of Scientific and Technical Information (OSTI.GOV)

McBride, A.E.

1998-12-01

The American Power Conference, 60th annual meeting, 1998, addressed reliability and economy as related to technology for competition and globalization. The topics of the papers included needs and advances in power engineering education, global climate change, distributed generation, the critical role of the nations largest coal, nuclear and hydropower stations, advances in generation technology, financing electric power projects, successful deregulation, year 2000 outlook for equipment conflict with information and control, system planning, asset management, relay and communication, particulate and SO{sub x} control, environmental protection compliance strategies, fuel cells, gas turbines, renewable energy, steam turbines, and cost reduction strategies.

Intelligent modular star and target tracker: a new generation of attitude sensors

NASA Astrophysics Data System (ADS)

Schmidt, Uwe; Strobel, Rainer; Wunder, Dietmar; Graf, Eberhart

2018-04-01

This paper, "Intelligent modular star and target tracker: a new generation of attitude sensors," was presented as part of International Conference on Space Optics—ICSO 1997, held in Toulouse, France.

Eliminating Health Disparities Among Minority Women: A Report on Conference Workshop Process and Outcomes

PubMed Central

Kritek, Phyllis Beck; Hargraves, Martha; Cuellar, Ernestine H.; Dallo, Florence; Gauthier, Donna M.; Holland, Christi A.; Ilkiw, Connie; Swanson, Jane W.; Swanson, Reid

2002-01-01

A national conference convened in May 2001 explored health disparities among minority women. It included 5 one-hour workshops that randomly assigned each participant to 1 of 4 groups. Groups generated recommendations on conference topics and from these identified priority recommendations. Trained facilitators guided groups through brainstorming and weighted voting processes; individual recommendations were submitted in writing. Participants generated 598 recommendations, 71 of them voted as priorities; these were analyzed to capture participants' “messages.” Central themes focused on access issues and cultural incompetence as deterrents to the elimination of health disparities and on education, funding, and community-based, community-driven research as mechanisms for change. Strategies for change included reinventing or expanding the role of minority communities and changing health care itself and “how” it does its work. The essential element in all recommendations was community leadership and control. PMID:11919057

Conference scene: progress with promising human antibodies.

PubMed

Larrick, James W

2012-03-01

Antibodies and antibody-based therapeutics have become big business, with annual sales over US$50 billion, accounting for >6% of worldwide pharmaceutical revenues. Ten molecules have blockbuster status (>US$1 billion), with six generating more than US$6 billion in sales. In excess of 300 products based on this rapidly maturing technology are in clinical trials. The generation and manufacture of human antibodies is now routine, although the cost of goods remains an issue. Optimizing combinations of antibodies with other therapeutics (e.g., chemotherapy) is a major short-term goal, while target validation and product differentiation remain significant hurdles if growth is to continue. Some of the notable highlights of the recent 16th International Conference on Human Antibodies and Hybridomas meeting in Cannes, France are described below. The conference was sponsored by the international journal Human Antibodies, in association with the Integrative Medical Sciences Association (IMSA). The Program Chairman was Professor Mark Glassy, IMSA, San Diego, CA, USA.

Rio Grande/Rio Bravo Basin Coalition

Treesearch

Sarah Kotchian

1999-01-01

In June 1994, one hundred people gathered for the first Uniting the Basin Conference in El Paso to discuss the state of their basin and to explore ways to improve its sustainability for future generations. One of the recommendations of that conference was the formation of an international non-governmental coalition of groups throughout the Basin to share information...

Investing in Youth: A Compilation of Recommended Policies and Practices. National Conference (New Orleans, Louisiana, December 9-11, 1992).

ERIC Educational Resources Information Center

National Governors' Association, Washington, DC.

These proceedings include 13 "perspectives from the field" and 9 selected papers (with abstracts) from a national conference on recommended policies and practices for investing in youth. The 13 perspectives papers are as follows: "Saving the Next Generation" (Berlin); "Effective Strategies for Investing in Youth"…

Navigating the Information Ocean: Charting the Course. Abstracts from the Academic Library Association of Ohio Annual Conference (Columbus, Ohio, November 4, 1994).

ERIC Educational Resources Information Center

Academic Library Association of Ohio.

Abstracts of 14 papers presented at the conference are provided here. Titles are: "Electronic Information Terraforming: Designing and Implementing a Front-end System Using World-Wide Web Technology" (Abbie Basile; And Others); "Characteristics of Generation X and Implications for Reference and Instructional Services" (Catherine…

Proceeding of the ACM/IEEE-CS Joint Conference on Digital Libraries (1st, Roanoke, Virginia, June 24-28, 2001).

ERIC Educational Resources Information Center

Association for Computing Machinery, New York, NY.

Papers in this Proceedings of the ACM/IEEE-CS Joint Conference on Digital Libraries (Roanoke, Virginia, June 24-28, 2001) discuss: automatic genre analysis; text categorization; automated name authority control; automatic event generation; linked active content; designing e-books for legal research; metadata harvesting; mapping the…

Moving beyond the Reflectivity of Post-Lesson Mentoring Conferences in Teacher Education and Creating Learning/development Opportunities for Pre-Service Teachers

ERIC Educational Resources Information Center

Ciavaldini-Cartaut, Solange

2015-01-01

This longitudinal case study suggests ways to move beyond the reflective process usually associated with post-lesson mentoring conferences by describing the modalities likely to generate real learning/development opportunities. Based on cultural-historical activity theories (CHAT) and using methodologies from sociodiscursive interactionism, this…

IFLA General Conference, 1986. Special Libraries Division. Section: Geography and Map Library. Papers.

ERIC Educational Resources Information Center

International Federation of Library Associations and Institutions, The Hague (Netherlands).

Four papers on geography and map libraries were presented at the 1986 International Federation of Library Associations (IFLA) conference. "Generation and Utilization of Maps and Atlases in Japan," by Takashi Morita of Japan, presents an overview of the making and uses of maps and atlases in Japan and concludes that a comprehensive…

[3 summit conferences on Earth insufficient to save the Planet, Controversies and achievements].

PubMed

Pérez Pérez, Félix

2003-01-01

This review summarizes the present concerns on the deteriorated biological systems. This concern has generated many publications since it is a very serious subject. The human being has produced a deep impact on the environment that could even could induce climatic changes. Because these circumstances have increased the socioeconomical differences between developed and third world countries, the United Nations Organization had organized three summit conferences (Oslo, 1972; Rio do Janeiro, 1992; Johannesburgh, 2002) in order to propose solutions. This review discusses the conclusions held at these conferences.

Twelve tips for delivering successful interprofessional case conferences.

PubMed

O'Brien, Bridget C; Patel, Shalini R; Pearson, Meg; Eastburn, Abigail P; Earnest, Gillian E; Strewler, Anna; Gager, Krista; Manuel, Jennifer K; Dulay, Maya; Bachhuber, Melissa R; Shunk, Rebecca

2017-12-01

Interprofessional case conferences (ICCs) offer an interactive, practical way to engage members of two or more health professions in discussions that involve learning and working together to improve patient care. Well-orchestrated ICCs provide opportunities to integrate interprofessional (IP) education into routine clinical practice. The authors provide 12 tips to support the conceptualization, planning, implementation, facilitation, evaluation, and sustainability of ICCs. They draw from extensive experience as IP educators and facilitators of ICCs and from literature on IP education, case-based learning, small-group facilitation, peer-assisted learning, and learner engagement - all of which offer insights into ICCs but have not been integrated and applied to this context.

Learning from a lifetime of leading effective change.

PubMed

Johnson, Claire; Clum, Gerard; Lassiter, Wright L; Phillips, Reed; Sportelli, Louis; Hunter, James C

2014-12-01

The purpose of this article is to report on the opening plenary session of the Association of Chiropractic Colleges Educational Conference-Research Agenda Conference (ACC-RAC) 2014, "Aiming for Effective Change: Leadership in Chiropractic Education, Research and Clinical Practice." Speakers with extensive backgrounds with implementing substantial change on a broad level shared personal examples from their experiences in education, research, political organizations, and clinical practice. They described efforts, challenges, and opportunities that are encountered in order to implement effective change and shared their personal thoughts on leadership. Each of the speakers shared their diverse, unique insights and personal experiences to convey the process and meaning of leadership.

All Africa conference on tobacco control.

PubMed Central

Chapman, S.; Yach, D.; Saloojee, Y.; Simpson, D.

1994-01-01

Although the health hazards of smoking are now generally accepted in most Western countries, the arguments have not had much impact on poorer nations. A conference on tobacco control held in Harare, Zimbabwe, in November last year was the largest to tackle this problem. The conference heard how threats of epidemics of tobacco related disease in the distant future held little weight with governments of countries that often already had massive public health problems. More immediate effects needed to be emphasised. Speakers gave three cogent arguments; firstly, the loss of capacity for foreign trade in essential goods, since most African countries are net importers of tobacco; secondly, the extensive deforestation which is occurring to fuel the flue curing of tobacco; thirdly, evidence from Papua New Guinea that raising taxation on tobacco provides governments with increased income for many years before a decrease begins. Images p190-a PMID:8312774

China's quest for management of academic medicine.

PubMed

Butler, W T; Ruma, S J

1990-08-01

The China Medical Board organized a management conference for the presidents of China's national medical universities. A three-person consulting team arranged by the Association of American Medical Colleges led the conference. Designed as a preliminary examination of the management problems faced by the national medical universities, the conference covered content similar to that of the AAMC Executive Development Seminars, including governance, financial management, faculty practice plans, technology transfer, information management, and organizational diagnosis. China's national medical universities are strategically managed by the Ministry of Public Health in Beijing, and for several years the ministry has increasingly decentralized the management and operational planning and control of these universities. The universities do not have enough properly trained personnel to absorb the additional management responsibilities, and the university presidents feel that they and their senior staffs need extensive training in adapting western-style management principles and practice to the Chinese setting.

Risky business: The impact of climate and climate variability on human population dynamics in Western Europe during the Last Glacial Maximum

NASA Astrophysics Data System (ADS)

Burke, Ariane; Kageyama, Masa; Latombe, Guilllaume; Fasel, Marc; Vrac, Mathieu; Ramstein, Gilles; James, Patrick M. A.

2017-05-01

The extent to which climate change has affected the course of human evolution is an enduring question. The ability to maintain spatially extensive social networks and a fluid social structure allows human foragers to ;map onto; the landscape, mitigating the impact of ecological risk and conferring resilience. But what are the limits of resilience and to which environmental variables are foraging populations sensitive? We address this question by testing the impact of a suite of environmental variables, including climate variability, on the distribution of human populations in Western Europe during the Last Glacial Maximum (LGM). Climate variability affects the distribution of plant and animal resources unpredictably, creating an element of risk for foragers for whom mobility comes at a cost. We produce a model of habitat suitability that allows us to generate predictions about the probable distribution of human populations and discuss the implications of these predictions for the structure of human populations and their social and cultural evolution during the LGM.

Multicellularity makes somatic differentiation evolutionarily stable

PubMed Central

Wahl, Mary E.; Murray, Andrew W.

2016-01-01

Many multicellular organisms produce two cell lineages: germ cells, whose descendants produce the next generation, and somatic cells, which support, protect, and disperse the germ cells. This germ-soma demarcation has evolved independently in dozens of multicellular taxa but is absent in unicellular species. A common explanation holds that in these organisms, inefficient intercellular nutrient exchange compels the fitness cost of producing nonreproductive somatic cells to outweigh any potential benefits. We propose instead that the absence of unicellular, soma-producing populations reflects their susceptibility to invasion by nondifferentiating mutants that ultimately eradicate the soma-producing lineage. We argue that multicellularity can prevent the victory of such mutants by giving germ cells preferential access to the benefits conferred by somatic cells. The absence of natural unicellular, soma-producing species previously prevented these hypotheses from being directly tested in vivo: to overcome this obstacle, we engineered strains of the budding yeast Saccharomyces cerevisiae that differ only in the presence or absence of multicellularity and somatic differentiation, permitting direct comparisons between organisms with different lifestyles. Our strains implement the essential features of irreversible conversion from germ line to soma, reproductive division of labor, and clonal multicellularity while maintaining sufficient generality to permit broad extension of our conclusions. Our somatic cells can provide fitness benefits that exceed the reproductive costs of their production, even in unicellular strains. We find that nondifferentiating mutants overtake unicellular populations but are outcompeted by multicellular, soma-producing strains, suggesting that multicellularity confers evolutionary stability to somatic differentiation. PMID:27402737

ISMB/ECCB 2009 Stockholm

PubMed Central

Sagot, Marie-France; McKay, B.J. Morrison; Myers, Gene

2009-01-01

The International Society for Computational Biology (ISCB; http://www.iscb.org) presents the Seventeenth Annual International Conference on Intelligent Systems for Molecular Biology (ISMB), organized jointly with the Eighth Annual European Conference on Computational Biology (ECCB; http://bioinf.mpi-inf.mpg.de/conferences/eccb/eccb.htm), in Stockholm, Sweden, 27 June to 2 July 2009. The organizers are putting the finishing touches on the year's premier computational biology conference, with an expected attendance of 1400 computer scientists, mathematicians, statisticians, biologists and scientists from other disciplines related to and reliant on this multi-disciplinary science. ISMB/ECCB 2009 (http://www.iscb.org/ismbeccb2009/) follows the framework introduced at the ISMB/ECCB 2007 (http://www.iscb.org/ismbeccb2007/) in Vienna, and further refined at the ISMB 2008 (http://www.iscb.org/ismb2008/) in Toronto; a framework developed to specifically encourage increased participation from often under-represented disciplines at conferences on computational biology. During the main ISMB conference dates of 29 June to 2 July, keynote talks from highly regarded scientists, including ISCB Award winners, are the featured presentations that bring all attendees together twice a day. The remainder of each day offers a carefully balanced selection of parallel sessions to choose from: proceedings papers, special sessions on emerging topics, highlights of the past year's published research, special interest group meetings, technology demonstrations, workshops and several unique sessions of value to the broad audience of students, faculty and industry researchers. Several hundred posters displayed for the duration of the conference has become a standard of the ISMB and ECCB conference series, and an extensive commercial exhibition showcases the latest bioinformatics publications, software, hardware and services available on the market today. The main conference is preceded by 2 days of Special Interest Group (SIG) and Satellite meetings running in parallel to the fifth Student Council Symposium on 27 June, and in parallel to Tutorials on 28 June. All scientific sessions take place at the Stockholmsmässan/Stockholm International Fairs conference and exposition facility. Contact: bj@iscb.org PMID:19447790

2010 Plant Molecular Biology Gordon Research Conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Michael Sussman

The Plant Molecular Biology Conference has traditionally covered a breadth of exciting topics and the 2010 conference will continue in that tradition. Emerging concerns about food security have inspired a program with three main themes: (1) genomics, natural variation and breeding to understand adaptation and crop improvement, (2) hormonal cross talk, and (3) plant/microbe interactions. There are also sessions on epigenetics and proteomics/metabolomics. Thus this conference will bring together a range of disciplines, will foster the exchange of ideas and enable participants to learn of the latest developments and ideas in diverse areas of plant biology. The conference provides anmore » excellent opportunity for individuals to discuss their research because additional speakers in each session will be selected from submitted abstracts. There will also be a poster session each day for a two-hour period prior to dinner. In particular, this conference plays a key role in enabling students and postdocs (the next generation of research leaders) to mingle with pioneers in multiple areas of plant science.« less

Epigenetics Europe conference. Munich, Germany, 8-9 September 2011.

PubMed

Jeltsch, Albert

2011-12-01

At the Epigenetics Europe conference in Munich, Germany, held on 8-9 September 2011, 19 speakers from different European countries were presenting novel data and concepts on molecular epigenetics. The talks were mainly focused on questions of the generation, maintenance, flexibility and erasure of DNA methylation patterns in context of other epigenetic signals like histone tail modifications and ncRNAs.

Annual Conference on Nuclear and Space Radiation Effects, 17th, Cornell University, Ithaca, N.Y., July 15-18, 1980, Proceedings

NASA Technical Reports Server (NTRS)

Mcgarrity, J. M.

1980-01-01

The conference covered the radiation effects on devices, circuits, and systems, physics and basic radiation effects in materials, dosimetry and radiation transport, spacecraft charging, and space radiation effects. Other subjects included single particle upset phenomena, systems-generated electromagnetic pulse phenomena, fabrication of hardened components, testing techniques, and hardness assurance.

The Significance of Parents' and Grandparents' Role. Proceedings of the Fenno-Hungarian Conference on Developmental Psychology (3rd, Lahti, Finland, July 11-13, 1993).

ERIC Educational Resources Information Center

Kalliopuska, Mirja, Ed.

The third Fenno-Hungarian Conference on Developmental Psychology covered four main concepts: the historical roots and development of social competence through three generations, parent-child interaction, parenthood, and the development of socio-cognitive competence through childhood and adolescence. A series of papers was presented addressing the…

High-resolution genetic and physical mapping of eastern filbert blight resistance in hazelnut

Treesearch

Vidyasagar Sathuvall; Shawn A. Mehlenbacher

2012-01-01

Eastern filbert blight (EFB), caused by the pyrenomycete Anisogramma anomala, is a serious threat to the hazelnut (Corylus avellana L.) industry in the Pacific Northwest. A dominant allele at a single locus from the obsolete pollenizer 'Gasaway' confers a very high level of resistance, and has been extensively used in...

Introduction to the Red Pine SAF Region V Technical Conference, March 26-27, 2002

Treesearch

Thomas R. Crow

2002-01-01

Research on managing red pine has been ongoing for some time and management guides that incorporate information resulting from this research such as Buckman's (1962) Growth and Yield of Red Pine in Minnesota and Benzie's (1977) Manager's Handbook for Red Pine have been widely applied. Despite this extensive knowledge...

Adapting Science Materials for the Blind, Report of an Evaluation Planning Conference.

ERIC Educational Resources Information Center

Thier, Herbert D.; And Others

Persons from the field of science education and persons who had extensive experience working with visually handicapped children were brought together to establish some baselines and beginning ideas of approaches to the evaluation of a laboratory - centered science program (Science Curriculum Improvement Study) as it is being used with visually…

Increasing Understanding of Public Problems and Policies--1992.

ERIC Educational Resources Information Center

Halbrook, Steve A., Ed.; Grace, Teddee E., Ed.

This publication reports the major discussions at a conference that was held to improve the policy education efforts of extension workers responsible for public affairs programs. It begins with abstracts of the 22 presentations. Four papers deal with public policy education in the 1990s: "To Inform Their Discretion: Policy Education and…

A southern region conference on technology transfer and extension

Treesearch

Sarah F. Ashton; William G. Hubbard; H. Michael Rauscher

2009-01-01

Forest landowners and managers have different education and technology transfer needs and preferences. To be effective it is important to use a multi-faceted science delivery/technology transfer program to reach them. Multi-faceted science delivery programs can provide similar content over a wide range of mechanisms including printed publications, face-to-face...

DDS, 4,4′-diaminodiphenylsulfone, extends organismic lifespan

PubMed Central

Keam, Bhumsuk; Choi, Jung Min; Cho, Yunje; Hyun, Soonsil; Park, Sang Chul; Lee, Junho

2010-01-01

DDS, 4,4′-diaminodiphenylsulfone, is the most common drug prescribed to treat Hansen disease patients. In addition to its antibacterial activity, DDS has been reported to be involved in other cellular processes that occur in eukaryotic cells. Because DDS treatment significantly enhances the antioxidant activity in humans, we examined its effect on lifespan extension. Here we show that DDS extends organismic lifespan using Caenorhabditis elegans as a model system. DDS treatment caused a delay in aging and decreased the levels of a mitochondrial complex. The oxygen consumption rate was also significantly lowered. Consistent with these data, paraquat treatment evoked less reactive oxygen species in DDS-treated worms, and these worms were less sensitive to paraquat. Interestingly enough, all of the molecular events caused by DDS treatment were consistently reproduced in mice treated with DDS for 3 mo and in the C2C12 muscle cell line. Structural prediction identified pyruvate kinase (PK) as a protein target of DDS. Indeed, DDS bound and inhibited PK in vitro and inhibited it in vivo, and a PK mutation conferred extended lifespan of C. elegans. Supplement of pyruvate to the media protected C2C12 cells from apoptosis caused by paraquat. Our findings establish the significance of DDS in lowering reactive oxygen species generation and extending the lifespan, which renders the rationale to examining the possible effect of DDS on human lifespan extension. PMID:20974969

Groin Pain Syndrome Italian Consensus Conference on terminology, clinical evaluation and imaging assessment in groin pain in athlete

PubMed Central

Bisciotti, G N; Volpi, P; Zini, R; Auci, A; Aprato, A; Belli, A; Bellistri, G; Benelli, P; Bona, S; Bonaiuti, D; Carimati, G; Canata, G L; Cassaghi, G; Cerulli, S; Delle Rose, G; Di Benedetto, P; Di Marzo, F; Di Pietto, F; Felicioni, L; Ferrario, L; Foglia, A; Galli, M; Gervasi, E; Gia, L; Giammattei, C; Guglielmi, A; Marioni, A; Moretti, B; Niccolai, R; Orgiani, N; Pantalone, A; Parra, F; Quaglia, A; Respizzi, F; Ricciotti, L; Pereira Ruiz, M T; Russo, A; Sebastiani, E; Tancredi, G; Tosi, F; Vuckovic, Z

2016-01-01

The nomenclature and the lack of consensus of clinical evaluation and imaging assessment in groin pain generate significant confusion in this field. The Groin Pain Syndrome Italian Consensus Conference has been organised in order to prepare a consensus document regarding taxonomy, clinical evaluation and imaging assessment for groin pain. A 1-day Consensus Conference was organised on 5 February 2016, in Milan (Italy). 41 Italian experts with different backgrounds participated in the discussion. A consensus document previously drafted was discussed, eventually modified, and finally approved by all members of the Consensus Conference. Unanimous consensus was reached concerning: (1) taxonomy (2) clinical evaluation and (3) imaging assessment. The synthesis of these 3 points is included in this paper. The Groin Pain Syndrome Italian Consensus Conference reached a consensus on three main points concerning the groin pain syndrome assessment, in an attempt to clarify this challenging medical problem. PMID:28890800

Summary of talks and papers at ISCB-Asia/SCCG 2012

PubMed Central

2013-01-01

The second ISCB-Asia conference of the International Society for Computational Biology took place December 17-19, 2012, in Shenzhen, China. The conference was co-hosted by BGI as the first Shenzhen Conference on Computational Genomics (SCCG). 45 talks were presented at ISCB-Asia/SCCG 2012. The topics covered included software tools, reproducible computing, next-generation sequencing data analysis, transcription and mRNA regulation, protein structure and function, cancer genomics and personalized medicine. Nine of the proceedings track talks are included as full papers in this supplement. In this report we first give a short overview of the conference by listing some statistics and visualizing the talk abstracts as word clouds. Then we group the talks by topic and briefly summarize each one, providing references to related publications whenever possible. Finally, we close with a few comments on the success of this conference.

Report on annual utility oil buyers conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stambler, K.

1994-08-01

What was discussed at this year`s Utility Oil Buyers` Conference is summarized. This year`s conference was held in Boston and there were over 200 attendees representing over 130 different companies from the utility, oil trading, consulting and inspection industries. Attendees for this year`s came from as far away as Italy and Argentina. The mood at this year`s conference was somber, as each sector is feeling the effects of the decline in residual fuel oil demand--due to natural gas displacement, non-utility generation and an economy that is still lethargic. The topics that were covered ranged from {open_quotes}Life after Order 636{close_quotes} tomore » {open_quotes}Does Residual Fuel Oil Have a Future in a Utility Steam Boiler?{close_quotes} to {open_quotes}The Future of Shipping after OPA of 1990.{close_quotes} In addition, there were several topics that have been or will be covered at this conference.« less

10. international mouse genome conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Meisler, M.H.

Ten years after hosting the First International Mammalian Genome Conference in Paris in 1986, Dr. Jean-Louis Guenet presided over the Tenth Conference at the Pasteur Institute, October 7--10, 1996. The 1986 conference was a satellite to the Human Gene Mapping Workshop and had approximately 50 attendees. The 1996 meeting was attended by 300 scientists from around the world. In the interim, the number of mapped loci in the mouse increased from 1,000 to over 20,000. This report contains a listing of the program and its participants, and two articles that review the meeting and the role of the laboratory mousemore » in the Human Genome project. More than 200 papers were presented at the conference covering the following topics: International mouse chromosome committee meetings; Mutant generation and identification; Physical and genetic maps; New technology and resources; Chromatin structure and gene regulation; Rate and hamster genetic maps; Informatics and databases; and Quantitative trait analysis.« less

IHY-IPY conference report from Polar Gateways Arctic Circle Sunrise 2008

NASA Astrophysics Data System (ADS)

Cooper, John; Kauristie, Kirsti; Weatherwax, Allan; Thompson, Barbara; Sheehan, Glenn; Smith, Roger; Sandahl, Ingrid

Polar, heliophysical, and planetary science topics related to the International Heliophysical and Polar Years 2007-2009 were addressed during this unique circumpolar conference hosted January 23-29, 2008 at the new Barrow Arctic Research Center of the Barrow Arctic Science Consortium in Barrow, Alaska. Science presentations spanned the solar system from the polar Sun and heliospheric environment to Earth, Moon, Mars, Jupiter, Saturn, the Kuiper Belt, and the solar wind termination shock now crossed by both Voyager spacecraft. Many of the science presentations were made remotely via video conference or teleconference from Sweden, Norway, Russia, Canada, Antarctica, and the United States, spanning up to thirteen time zones (Alaska to Russia) at various times during the conference. U.S. remote contributions came from the University of Alaska at Fairbanks, the University of California at Berkeley, the University of Arizona, NASA Jet Propulsion Laboratory, and NASA Goddard Space Flight Center. Convening during the first week of 2008 Arctic sunrise at Barrow, this conference served as a prelude that year to international Sun-Earth Day celebrations for IHY, while also commemorating Barrow scientific and native cultural support for the first International Polar Year 1882-1883. Extensive educational outreach activities were conducted with the local Barrow and Alaska North Slope communities and through the NASA Digital Learning Network live from the "top of the world" at Barrow. The conference proceedings are Internet accessible via the home page at http://polargateways2008.org/.

Real Time Conference 2014 Overview

NASA Astrophysics Data System (ADS)

Nomachi, Masaharu

2015-06-01

This article presents an overview of the 19th Real Time Conference held last May 26-30, 2014, at the Nara Prefectural New Public Hall, Nara, Japan, organized by the Research Center for Nuclear Physics of the Osaka University. The program included many invited talks and oral sessions offering an extensive overview on the following topics: real-time system architectures, intelligent signal processing, fast data transfer links and networks, trigger systems, data acquisition, processing-farms, control, monitoring and test systems, emerging real-time technologies, new standards, real-time safety and security, and some feedback on experiences. In parallel to the oral and poster presentations, industrial exhibits by companies, workshops and short courses also ran through the week.

Assessing food safety training needs of environmental health specialists in the U.S.: focus group summary.

PubMed

Nummer, Brian; Fraser, Angela; Marcy, John; Klein, Ron

2010-04-01

As part of a U.S. Department of Agriculture Cooperative State Research, Education, and Extension Service grant, six focus group sessions on the topic of food safety education and training were held June 24, 2008, at NEHA's Annual Educational Conference & Exhibition in Tucson, Arizona. A total of 30 participants attended one of the six 50-minute sessions. Participants were NEHA conference attendees and nearly all stated they had a food safety training and education role in their job. A series of questions related to food safety at retail and food service levels was asked. This report summarizes some of the opinions provided by focus group participants.

4th Annual SATN Conference 2011: Curriculum Transformation at Universities of Technology: Towards Development of New Generation Universities

ERIC Educational Resources Information Center

Mthembu, T.

2012-01-01

The South African Technology Network (SATN) would like to thank the Editor of the "South African Journal of Higher Education" (SAJHE) for the opportunity to publish papers read at the 4th Annual SATN Conference that was hosted by Central University of Technology and held in Bloemfontein in November 2011. The journal makes it possible for…

Diagnostic and Therapeutic Radiopharmaceutical Agents for Selective Discrimination of Prostate Cancer

DTIC Science & Technology

2009-10-01

Bottenus, Brienne N.∞; Fugate, Glenn A.†; Benny, Paul*. Actinides Separations, Conference Pacific Northwest National Lab 6/2006 In situ formation of...Bottenus, Brienne N.∞; Benny, Paul*. Actinides Separations, Conference Pacific Northwest National Lab 3/12/2006 S-functionalized cysteine ligands...cancer imaging. The successful preparation and radiolabeling of the first generation of compounds illustrates one the key critical objectives being

Proceedings of the American power conference: Volume 59-1

DOE Office of Scientific and Technical Information (OSTI.GOV)

McBride, A.E.

1997-07-01

This is Volume 59-1 of the proceedings of the American Power Conference, 1997. The contents include environmental protection; regulatory compliance and permitting; convergence of electric and gas industries; renewable/wind energy; improving operations and maintenance; globalization of renewable, generation, and distribution technologies; diagnostics; battery reliability; access to power transmission facilities; software for competitive decision making and operation; transmission and distribution; and nuclear operations and options.

Report on Progress Toward Security and Stability in Afghanistan

DTIC Science & Technology

2010-04-01

which has resulted in continued capability gaps in the Combined Joint Statement of Requirements (CJSOR) from unresourced requirements not filled by...international partners. The most notable gap is the requirement for trainers and mentors to support development of the ANSF. U.S. Forces are taking...made at the December 2009 NATO Foreign Ministerial and February 2010 NATO Force Generation Conference. The December conference yielded contributions

Computing Accurate Grammatical Feedback in a Virtual Writing Conference for German-Speaking Elementary-School Children: An Approach Based on Natural Language Generation

ERIC Educational Resources Information Center

Harbusch, Karin; Itsova, Gergana; Koch, Ulrich; Kuhner, Christine

2009-01-01

We built a natural language processing (NLP) system implementing a "virtual writing conference" for elementary-school children, with German as the target language. Currently, state-of-the-art computer support for writing tasks is restricted to multiple-choice questions or quizzes because automatic parsing of the often ambiguous and fragmentary…

PREFACE: 5th Workshop of Young Researchers in Astronomy & Astrophysics

NASA Astrophysics Data System (ADS)

Forgács-Dajka, Emese; Plachy, Emese; Molnár, László

2010-04-01

The 5th Workshop of Young Researchers in Astronomy and Astrophysics was held on 2-4 September 2009 at the Eötvös University in Budapest, Hungary. This meeting fits into a conference series which can already be considered a tradition where the younger generation has the opportunity to present their work. The event was also a great opportunity for senior astronomers and physicists to form new connections with the next generation of researchers. The selection of invited speakers concentrated on the researchers currently most active in the field, mostly on a post-doctoral/tenure/fresh faculty position level. A number of senior experts and PhD students were also invited. As the conference focused on people rather than a specific field, various topics from theoretical physics to planetology were covered in three days. The programme was divided into six sections: Physics of the Sun and the Solar System Gravity and high-energy physics Galactic and extragalactic astronomy, cosmology Celestial mechanics and exoplanets Infrared astronomy and young stars Variable stars We had the pleasure of welcoming 10 invited review talks from senior researchers and 42 contributed talks and a poster from the younger generation. Participants also enjoyed the hospitality of the pub Pál at the Pálvölgyi-cave after giving, hearing and disputing countless talks. Brave souls even descended to the unbuilt, adventurous Mátyásvölgyi-cave. Memories of the conference were shadowed though. Péter Csizmadia, one of our participants and three other climbers attempted a first ever ascent to the Ren Zhong Feng peak in Sichuan, China, but they never returned from the mountains. Péter departed to China shortly after the conference, with best wishes from participants and friends. We dedicate this volume to his memory. The organisers thankthe Physics Doctoral School of Eötvös University for its hospitality. The workshop was supported by the Mecenatúra and Polányi Mihály Programmes of the National Office for Research and Technology (NKTH) and the Ministry of Education and Culture (OKM) of Hungary. Emese Forgács-Dajka, Emese Plachy and László Molnár Conference photograph Conference photograph

Next Generation Drivetrain Development and Test Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keller, Jonathan; Erdman, Bill; Blodgett, Doug

2015-11-03

This presentation was given at the Wind Energy IQ conference in Bremen, Germany, November 30 through December 2, 2105. It focused on the next-generation drivetrain architecture and drivetrain technology development and testing (including gearbox and inverter software and medium-voltage inverter modules.

THE AGONY OF THE INNER CITY, WHAT CAN CONTINUING EDUCATION DO.

ERIC Educational Resources Information Center

DRAZEK, STANLEY J.

THE REPORT OF A PANEL PROGRAM BY THE COUNCIL ON EXTENSION AT THE EIGHTY-FIRST NATIONAL CONFERENCE OF THE NATIONAL ASSOCIATION OF STATE UNIVERSITIES AND LAND-GRANT COLLEGES IN NOVEMBER, 1967, FEATURED URBAN AND UNIVERSITY LEADERS REPRESENTING DETROIT, MILWAUKEE, NEWARK, AND WATTS. THE FIRST ADDRESS COMPARED THE PLIGHT OF AMERICAN INNER CITY NEGRO…

Social Structure of the Contact Situation: Rural Appalachia and Urban America. Appalachian Center Information Report 1.

ERIC Educational Resources Information Center

Schwarzweller, Harry K.; Brown, James S.

An investigation of the characteristic structuring of rural communities in Appalachia and the institutional channels for change which exist within such communities comprise this revised version of a paper read at the Extension Leaders Conference, Morgantown, West Virginia, 1968. Specifically, this essay discusses how education, the mass media,…

Virginia Water Resources Research Center - at Virginia Tech since 1965

Science.gov Websites

Virginia Water Resources Research Center at Virginia Tech since 1965 Search for: Search Skip to collaborative research, extension, and education programs to develop solutions to water resource challenges. We Monitoring Council Conference: March 21, 2018 The Virginia Water Resources Research Center at Virginia Tech

The Many Histories of Community Psychology: Analyses of Current Trends and Future Prospects

ERIC Educational Resources Information Center

Fowler, Patrick J.; Toro, Paul A.

2008-01-01

Forty years since the seminal Swampscott Conference, the principles of community psychology transcend multiple areas of action and research, as well as international boundaries. The extensive development of community psychology offers an opportunity to examine from where the field has come and where it is going. Yet, a systematic approach to…

Governor's Conference on Drug Dependence and Abuse. An Occasional Paper of the Honors College.

ERIC Educational Resources Information Center

Milliken, William G.; And Others

1970-01-01

Following Governor Milliken's address, Dr. Dana Farnsworth defines the problem in terms of who's involved, to what extent, and with which drugs. His presentation focuses primarily on the motives of affluent young people who experiment with or become dependent upon hallucinogens, marihuana and amphetamines. He deals extensively with the drastically…

Library Standards and Guidelines for Institutions Affiliated with or Offering Extension Programs of Andrews University.

ERIC Educational Resources Information Center

Brenneise, Harvey, Ed.; And Others

Andrews University (Michigan), which is sponsored by the General Conference of Seventh-Day Adventists, extends its academic program to 14 other institutions, three in the United States and abroad. The program permits students in other countries to obtain a recognized, quality tertiary or graduate education. Andrews' research library, the James…

Press kit kicks off new branding.

PubMed

Rees, Tom

2004-01-01

A smartly produced press kit resulted in unprecedented news coverage when Denver's Porter Adventist Hospital recently unveiled plans for an extensive 80 million dollars redevelopment. A news conference was held to announce this plan, along with the opening of the hospital's new emergency department. The overall effort is part of the new branding strategy of the 75-year-old hospital.

Access, Outcomes, and Social Mobility in a Stratified System of Postsecondary Education

ERIC Educational Resources Information Center

Thompson, Jason

2017-01-01

Educational attainment sits at the core of research on social stratification in the United States. An extensive literature details the inequalities in access to levels of education, the socioeconomic rewards conferred upon those reaching higher levels of schooling, and the prospects for social mobility among those able to attain a college degree.…

Entertainment-Education: Dilemmas of Israeli Creators of Theatre about the Israeli-Palestinian Conflict in Promoting Peace

ERIC Educational Resources Information Center

Gesser-Edelsburg, Anat

2011-01-01

Israeli-Palestinian peace is promoted through political and diplomatic channels, as well as indirect channels such as conferences, lectures, meetings, workshops and political journalism. However, there is less awareness of the extensive artistic activity in Israel surrounding peace and its implications for society, or of the uniqueness of the…

Fungal genomes that influence basic physiological processes of black grama and fourwing saltbush in arid southwestern rangelands

Treesearch

J.R. Barrow; M. Lucero; P. Osuna-Avila; I. Reyes-Vera; R.E. Aaltonen

2007-01-01

Symbiotic fungi confer multiple benefits such as enhanced photosynthetic rates and drought tolerance in host plants. Shrubs and grasses of southwestern deserts are colonized by symbiotic fungi that cannot be removed by conventional sterilization methods. These fungi were extensively studied in Bouteloua eriopoda (Torr.) Torr. and Atriplex...

Proceedings of the Fifteenth Annual Conference on Fossil Energy Materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Judkins, R.R.

2002-02-12

The Fifteenth Annual Conference on Fossil Energy Materials was held in Knoxville, Tennessee, on April 30 through May 2, 2001. The meeting was sponsored by the U.S. Department of Energy's (DOE) Office of Fossil Energy through the Advanced Research Materials Program (ARM). The objective of the ARM Program is to conduct research and development on materials for longer-term fossil energy applications, as well as for generic needs of various fossil fuel technologies. The management of the program has been decentralized to the DOE Oak Ridge Operations Office and Oak Ridge National Laboratory (ORNL). The research is performed by staff membersmore » at ORNL and by researchers at other national laboratories, universities, and in private industry. The work is divided into the following categories: (1) structural, ceramics, (2) new alloys and coatings, (3) functional materials, and (4) technology development and transfer. These proceedings were produced primarily from electronic files provided by the authors. They have been neither refereed nor extensively edited. However, most of the papers have already undergone technical review within the individual organizations before submission to the Program Office. The proceedings are available on the Fossil Energy home page at http://www.ornl.gov/fossil (Workshops and Conferences). The successful completion of the conference and publication of the proceedings has required help from several people. The organizers wish to thank Angela Beach of the ORNL Conference Office for her help in the many arrangements, and the numerous staff and support personnel associated with the conference. Finally, we express our sincere appreciation to the authors whose efforts are the very basis of the conference.« less

Knowledge and institutional requirements to promote land degradation neutrality in drylands - An analysis of the outcomes of the 3rd UNCCD scientific conference

NASA Astrophysics Data System (ADS)

Akhtar-Schuster, Mariam; Safriel, Uriel; Abraham, Elena; de Vente, Joris; Essahli, Wafa; Escadafal, Richard; Stringer, Lindsay

2015-04-01

Achieving land degradation neutrality (LDN) through sustainable land management (SLM) targets the maintenance or restoration of the productivity of land, and therefore has to include decision-makers, knowledge generators and knowledge holders at the different relevant geographic scales. In order to enhance the implementation of the Convention, the Conference of the Parties (COP) of the United Nations Convention to Combat Desertification therefore decided that each future session of its Committee on Science and Technology (CST) would be organized in a predominantly scientific and technical conference-style format. This contribution will outline the major outcomes of UNCCD's 3rd scientific conference that will be held in Cancún, Mexico, from 9 to 12 March 2015, on addressing desertification, land degradation and drought issues (DLDD) for poverty reduction and sustainable development. The conference follows an exceptional new round table conference format that will allow the various stakeholders to discuss scientific as well as the contribution of traditional knowledge and practices in combating land degradation. This format should provide two-way communication and enable deeper insight into the availability and contribution of all forms of knowledge for achieving LDN through the assessment of: • the vulnerability of lands to DLDD and climate change and the adaptive capacities of socio-ecosystems; • best examples of adapted, knowledge-based practices and technologies; • monitoring and assessment methods to evaluate the effectiveness of adaptation practices and technologies. The outcomes of UNCCD's 3rd scientific conference will serve as a basis for discussing: • contributions of science to diagnose the status of land; • research gaps that need to be addressed to achieve LDN for poverty reduction; • additional institutional requirements to optimally bridge knowledge generation, knowledge maintenance and knowledge implementation at the science-policy interface.

Stress tolerance in plants via habitat-adapted symbiosis

USGS Publications Warehouse

Rodriguez, R.J.; Henson, J.; Van Volkenburgh, E.; Hoy, M.; Wright, L.; Beckwith, F.; Kim, Y.-O.; Redman, R.S.

2008-01-01

We demonstrate that native grass species from coastal and geothermal habitats require symbiotic fungal endophytes for salt and heat tolerance, respectively. Symbiotically conferred stress tolerance is a habitat-specific phenomenon with geothermal endophytes conferring heat but not salt tolerance, and coastal endophytes conferring salt but not heat tolerance. The same fungal species isolated from plants in habitats devoid of salt or heat stress did not confer these stress tolerances. Moreover, fungal endophytes from agricultural crops conferred disease resistance and not salt or heat tolerance. We define habitat-specific, symbiotically-conferred stress tolerance as habitat-adapted symbiosis and hypothesize that it is responsible for the establishment of plants in high-stress habitats. The agricultural, coastal and geothermal plant endophytes also colonized tomato (a model eudicot) and conferred disease, salt and heat tolerance, respectively. In addition, the coastal plant endophyte colonized rice (a model monocot) and conferred salt tolerance. These endophytes have a broad host range encompassing both monocots and eudicots. Interestingly, the endophytes also conferred drought tolerance to plants regardless of the habitat of origin. Abiotic stress tolerance correlated either with a decrease in water consumption or reactive oxygen sensitivity/generation but not to increased osmolyte production. The ability of fungal endophytes to confer stress tolerance to plants may provide a novel strategy for mitigating the impacts of global climate change on agricultural and native plant communities.The ISME Journal (2008) 2, 404-416; doi:10.1038/ismej.2007.106; published online 7 February 2008. ?? 2008 International Society for Microbial Ecology All rights reserved.

Crizotinib-Resistant Mutants of EML4-ALK Identified Through an Accelerated Mutagenesis Screen

PubMed Central

Zhang, Sen; Wang, Frank; Keats, Jeffrey; Zhu, Xiaotian; Ning, Yaoyu; Wardwell, Scott D; Moran, Lauren; Mohemmad, Qurish K; Anjum, Rana; Wang, Yihan; Narasimhan, Narayana I; Dalgarno, David; Shakespeare, William C; Miret, Juan J; Clackson, Tim; Rivera, Victor M

2011-01-01

Activating gene rearrangements of anaplastic lymphoma kinase (ALK) have been identified as driver mutations in non-small-cell lung cancer, inflammatory myofibroblastic tumors, and other cancers. Crizotinib, a dual MET/ALK inhibitor, has demonstrated promising clinical activity in patients with non-small-cell lung cancer and inflammatory myofibroblastic tumors harboring ALK translocations. Inhibitors of driver kinases often elicit kinase domain mutations that confer resistance, and such mutations have been successfully predicted using in vitro mutagenesis screens. Here, this approach was used to discover an extensive set of ALK mutations that can confer resistance to crizotinib. Mutations at 16 residues were identified, structurally clustered into five regions around the kinase active site, which conferred varying degrees of resistance. The screen successfully predicted the L1196M, C1156Y, and F1174L mutations, recently identified in crizotinib-resistant patients. In separate studies, we demonstrated that crizotinib has relatively modest potency in ALK-positive non-small-cell lung cancer cell lines. A more potent ALK inhibitor, TAE684, maintained substantial activity against mutations that conferred resistance to crizotinib. Our study identifies multiple novel mutations in ALK that may confer clinical resistance to crizotinib, suggests that crizotinib's narrow selectivity window may underlie its susceptibility to such resistance and demonstrates that a more potent ALK inhibitor may be effective at overcoming resistance. PMID:22034911

Proceedings of the American Power Conference. Volume 58-I

DOE Office of Scientific and Technical Information (OSTI.GOV)

McBride, A.E.

1996-10-01

This is volume 58-I of the proceedings of the American Power Conference, 1996, Technology for Competition and Globalization. The topics of the papers include power plant DC issues; cost of environmental compliance; advanced coal systems -- environmental performance; technology for competition in dispersed generation; superconductivity technologies for electric utility applications; power generation trends and challenges in China; aging in nuclear power plants; innovative and competitive repowering options; structural examinations, modifications and repairs; electric load forecasting; distribution planning; EMF effects; fuzzy logic and neural networks for power plant applications; electrokinetic decontamination of soils; integrated gasification combined cycle; advances in fusion; coolingmore » towers; relays; plant controls; flue gas desulfurization; waste product utilization; and improved technologies.« less

Staying Innovative and Change-Focused in the New Economy. A Collection of Special Papers Generated for the 2001 International Career Development Conference (Seattle, Washington, November 7-11, 2001).

ERIC Educational Resources Information Center

Walz, Garry R., Ed.; Knowdell, Richard, Ed.; Kirkman, Chris, Ed.

This publication is designed to broaden exposure to the ideas presented at the 2001 International Career Development Conference. It provides authors with an international forum for communicating their current research, proposals, and projects to the international career development community. The articles in this symposium include: (1) "Chaos,…

Renewable Electricity Futures (Presentation)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hand, M. M.

2012-08-01

This presentation library summarizes findings of NREL's Renewable Electricity Futures study, published in June 2012. RE Futures investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. It was presented to the 2012 Western Conference of Public Service Commissioners, during their June, 2012, meeting. The Western Conference of Public Service Commissioners is a regional association within the National Association of Regulatory Utility Commissioners (NARUC).

Second Generation of Mass Estimation

DTIC Science & Technology

2013-09-01

Takashi Washio, Jonathan R. Wells, Fei Tony Liu and Sunil Aryal (2013). DEMass: A New Density Estimator for Big Data. International Journal of Knowledge...and Information Systems. Vol. 35, Issue. 3, pp. 493-524 5.2 List of peer-reviewed conference publications [3] Sunil Aryal and Kai Ming Ting (2013...Measures. Submitted to 2013 IEEE International Conference on Data Mining [6] Sunil Aryal and Kai Ming Ting. An ensemble approach to estimate multi

Case Study 2: Using Games Based on Giant Dice and Time Restrictions to Enable Creativity When Teaching Artistic or Creative Subjects

ERIC Educational Resources Information Center

Barnard, Dan

2017-01-01

This case study draws on some experiments I have been doing in the use of dice in the ideas generation phase of a creative project. It draws on workshops I have run with creative technology students at Goldsmiths, with a range of adults at the Counterplay Conference in Aarhus (Denmark) and the Playful Learning Conference at Manchester Metropolitan…

Improving Generation Y Volunteerism in Extension Programs

ERIC Educational Resources Information Center

Andrews, Kevin B.; Lockett, Landry L.

2013-01-01

Members of Generation Y have many positive attributes that make them attractive to Extension volunteer administrators as a potential source of labor. However, they think differently, have unique needs, require new management styles, and have less tolerance for unpleasant working conditions than previous generations. Additionally, they are engaged…

Space Electrochemical Research and Technology

NASA Technical Reports Server (NTRS)

1991-01-01

The proceedings of NASA's third Space Electrochemical Research and Technology (SERT) conference are presented. The objective of the conference was to assess the present status and general thrust of research and development in those areas of electrochemical technology required to enable NASA missions in the next century. The conference provided a forum for the exchange of ideas and opinions of those actively involved in the field, in order to define new opportunities for the application of electrochemical processes in future NASA missions. Papers were presented in three technical areas: the electrochemical interface, the next generation in aerospace batteries and fuel cells, and electrochemistry for nonenergy storage applications.

Proceedings of the Fifth International Mobile Satellite Conference 1997

NASA Technical Reports Server (NTRS)

Jedrey, T. (Compiler); Rigley, J. (Compiler); Anderson, Louise (Editor)

1997-01-01

Satellite-based mobile communications systems provide voice and data communications to users over a vast geographic area. The users may communicate via mobile or hand-held terminals, which may also provide access to terrestrial communications services. While previous International Mobile Satellite Conferences have concentrated on technical advances and the increasing worldwide commercial activities, this conference focuses on the next generation of mobile satellite services. The approximately 80 papers included here cover sessions in the following areas: networking and protocols; code division multiple access technologies; demand, economics and technology issues; current and planned systems; propagation; terminal technology; modulation and coding advances; spacecraft technology; advanced systems; and applications and experiments.

Provider competition and health care quality: challenges and opportunities for research.

PubMed

Wong, Herbert S; McNamara, Peggy; Greenberg, Warren

2004-06-01

On May 28, 2003, the Agency for Healthcare Research and Quality and the Federal Trade Commission co-sponsored an invitational conference entitled, "Provider Competition and Quality: Latest Findings and Implications for the Next Generation of Research." The main objectives of this conference were to share and discuss the latest findings on provider competition and quality, to identify implications for antitrust policy, and to develop an agenda for further research in this area. While it is impossible to completely capture the rich exchange of ideas and perspectives that transpired at the conference, we highlight several key themes that emerged and present a research agenda to guide future investigations.

77 FR 36532 - Review of Small Generator Interconnection Agreements and Procedures; Solar Energy Industries...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-19

...; ER12-502-001; ER12-502-002; ER12- 1177-001; ER12-1855-000] Review of Small Generator Interconnection... Commission, 888 First Street NE., Washington, DC 20426. Members of the Commission may attend the conference... register at the following Web page: https://www.ferc.gov/whats-new/registration/small-generator-7-17-12...

Energy in perspective: an orientation conference for educators. [28 presentations

DOE Office of Scientific and Technical Information (OSTI.GOV)

McKlveen, J.W.

An awareness of energy and the pertinent economic, environmental, and risk/benefit consideration must be presented to the public. A logical beginning point is in the classroom, through knowledgeable and motivated educators. Ms. Carolyn Warner, Superintendent of Public Instruction, State of Arizona, presented the first paper, Energy and the Educator. Papers on all aspects of energy were presented at the conference by experts from throughout the United States. The papers were: Energy Resources: World and U.S.A.; Coal Technology: Mining, Energy Generation, Wastes, and Environmental Considerations; Energy Conservation; Arizona's Energy Resources and Development; Gas and Oil: Natural Gas, S.N.G., Oil, Oil Shale,more » and Tar Sands; Geothermal Energy Perspective; Solar Energy; Solar Technology; Natural Radiation Environment; Fission Theory; Arizona's Palo Verde Nuclear Generation Complex; Gas Cooled Reactors, Liquid Metal Reactors and Alternatives; Radioactive Wastes: Disposal Alternatives; Reactor Safety; Nuclear Safeguards; Fusion Power; Genetic and Somatic Radiation Effects; Energy Economics; Religion, Philosophy, and Energy; Nuclear Studies in Fine Arts and Archeology; Nuclear Methods Applied to Agriculture and Food Preservation; Nuclear Methods in Criminology; Environmental Impact of Energy Generation; and Risk and Insurance Consideration--Energy for Tomorrow. The tours to energy installations conducted during the conference and demonstration related to energy are cited. (MCW)« less

The role of adaptive trans-generational plasticity in biological invasions of plants

USDA-ARS?s Scientific Manuscript database

Trans-generational plasticity (TGP) that confers greater offspring fitness is likely to be an important mechanism contributing to the spread of some invasive plant species. TGP is predicted for populations found in habitats with predictable spatial or temporal resource heterogeneity, and that have ...

The Solanum tuberosum KST1 partial promoter as a tool for guard cell expression in multiple plant species.

PubMed

Kelly, Gilor; Lugassi, Nitsan; Belausov, Eduard; Wolf, Dalia; Khamaisi, Belal; Brandsma, Danja; Kottapalli, Jayaram; Fidel, Lena; Ben-Zvi, Batsheva; Egbaria, Aiman; Acheampong, Atiako Kwame; Zheng, Chuanlin; Or, Etti; Distelfeld, Assaf; David-Schwartz, Rakefet; Carmi, Nir; Granot, David

2017-05-17

To date, guard cell promoters have been examined in only a few species, primarily annual dicots. A partial segment of the potato (Solanum tuberosum) KST1 promoter (KST1 partial promoter, KST1ppro) has previously been shown to confer guard cell expression in potato, tomato (Solanum lycopersicum), citrus [Troyer citrange (C. sinensis×Poncirus trifoliata)], and Arabidopsis (Arabidopsis thaliana). Here, we describe an extensive analysis of the expression pattern of KST1ppro in eight (previously reported, as well as new) species from five different angiosperm families, including the Solanaceae and the Cucurbitaceae, Arabidopsis, the monocot barley (Hordeum vulgare), and two perennial species: grapevine (Vitis vinifera) and citrus. Using confocal imaging and three-dimensional movies, we demonstrate that KST1ppro drives guard cell expression in all of these species, making it the first dicot-originated guard cell promoter shown to be active in a monocot and the first promoter reported to confer guard cell expression in barley and cucumber (Cucumis sativus). The results presented here indicate that KST1ppro can be used to drive constitutive guard cell expression in monocots and dicots and in both annual and perennial plants. In addition, we show that the KST1ppro is active in guard cells shortly after the symmetric division of the guard mother cell and generates stable expression in mature guard cells. This allows us to follow the spatial and temporal distribution of stomata in cotyledons and true leaves. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology.

Gordon Research Conference on Nonlinear Optics and Lasers

NASA Astrophysics Data System (ADS)

Haus, Hermann

1992-02-01

The topics chosen were production of X rays with high power lasers, generation of millimeter waves with femtosecond pulses, microcavities and microlasers, second harmonic generation in fibers and advances in photorefractivity and parallel optical processing. It introduces ways of thinking and scientific methods in fields that are related, but would not generally appear in specialized conferences. There were three such examples: the methods of nonlinear optics as applied to electronic signal processing, the concept of squeezing (special quantum states of the electromagnetic field) as used to explain the generation of gravitational waves in the expanding universe, and particle interferometers with particle- instead of wave-gratings. By asking Nobel laureate Bloembergen one year in advance to give the traditional after dinner speech, we were privileged to hear him speak of the history of optics over the centuries resulting in the various principles of linear optics, and the highly accelerated pace of discovery of the analogous principles in nonlinear optics.

Nuclear Rocket Technology Conference

NASA Technical Reports Server (NTRS)

1966-01-01

The Lewis Research Center has a strong interest in nuclear rocket propulsion and provides active support of the graphite reactor program in such nonnuclear areas as cryogenics, two-phase flow, propellant heating, fluid systems, heat transfer, nozzle cooling, nozzle design, pumps, turbines, and startup and control problems. A parallel effort has also been expended to evaluate the engineering feasibility of a nuclear rocket reactor using tungsten-matrix fuel elements and water as the moderator. Both of these efforts have resulted in significant contributions to nuclear rocket technology. Many successful static firings of nuclear rockets have been made with graphite-core reactors. Sufficient information has also been accumulated to permit a reasonable Judgment as to the feasibility of the tungsten water-moderated reactor concept. We therefore consider that this technoIogy conference on the nuclear rocket work that has been sponsored by the Lewis Research Center is timely. The conference has been prepared by NASA personnel, but the information presented includes substantial contributions from both NASA and AEC contractors. The conference excludes from consideration the many possible mission requirements for nuclear rockets. Also excluded is the direct comparison of nuclear rocket types with each other or with other modes of propulsion. The graphite reactor support work presented on the first day of the conference was partly inspired through a close cooperative effort between the Cleveland extension of the Space Nuclear Propulsion Office (headed by Robert W. Schroeder) and the Lewis Research Center. Much of this effort was supervised by Mr. John C. Sanders, chairman for the first day of the conference, and by Mr. Hugh M. Henneberry. The tungsten water-moderated reactor concept was initiated at Lewis by Mr. Frank E. Rom and his coworkers. The supervision of the recent engineering studies has been shared by Mr. Samuel J. Kaufman, chairman for the second day of the conference, and Mr. Roy V. Humble. Dr. John C. Eward served as general chairman for the conference.

Third CLIPS Conference Proceedings, volume 2

NASA Technical Reports Server (NTRS)

Riley, Gary (Editor)

1994-01-01

Expert systems are computer programs which emulate human expertise in well defined problem domains. The C Language Integrated Production System (CLIPS) is an expert system building tool, developed at the Johnson Space Center, which provides a complete environment for the development and delivery of rule and/or object based expert systems. CLIPS was specifically designed to provide a low cost option for developing and deploying expert system applications across a wide range of hardware platforms. The development of CLIPS has helped to improve the ability to deliver expert system technology throughout the public and private sectors for a wide range of applications and diverse computing environments. The Third Conference on CLIPS provided a forum for CLIPS users to present and discuss papers relating to CLIPS applications, uses, and extensions.

77 FR 3010 - In the Matter of Mr. Francis Guilbeau; Order Prohibiting Involvement in NRC-Licensed Activities

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-20

... request a predecisional enforcement conference or request alternative dispute resolution (ADR) with the... the absence of any request for hearing or ADR, or written approval of an extension of time in which to... hearing or ADR is requested, the effective date of this Order shall be determined in accordance with the...

Use of Adaptive Study Material in Education in E-Learning Environment

ERIC Educational Resources Information Center

Kostolányová, Katerina; Šarmanová, Jana

2014-01-01

Personalised education is a topical matter today and the impact of ICT on education has been covered extensively. The adaptation of education to various types of student is an issue of a vast number of papers presented at diverse conferences. The topic incorporates the fields of information technologies and eLearning, but in no small part also the…

Written Artefacts in Post-Conference Feedback Sessions: The Running Commentary as a Support for Teacher Learning

ERIC Educational Resources Information Center

Engin, Marion

2015-01-01

Written artefacts often form a significant part of teacher education activities and play a crucial role in the dialogue between tutor and student teacher in a post-observation feedback session. However, although the dialogue of feedback sessions has been extensively researched, the role of the artefact has been less explored. This research…

Ectopic expression of Arabidopsis genes encoding salicylic acid- and jasmonic acid-related proteins confers partial resistance to soybean cyst nematode (Heterodera glycines) in transgenic soybean roots

USDA-ARS?s Scientific Manuscript database

Background. Extensive studies using the model system Arabidopsis thaliana to elucidate plant defense signaling and pathway networks indicate that salicylic acid (SA) is the key hormone triggering the plant defense response against biotrophic and hemi-biotrophic pathogens, while jasmonic acid (JA) an...

Conference report from the 2015 OECI Oncology Days, Portugal, 22–24 June—tumour heterogeneity and next generation sequencing: morphology and technology

PubMed Central

Cairns, Linda

2015-01-01

Tumour heterogeneity was the topic of the ‘Oncology Days’ series held at the 2015 OECI conference in which experts within the field provided an update on tumour heterogeneity and its relevance in the clinical setting. Here we present a summary of the presentations from the two major sessions of the meeting: clonal heterogeneity and phenotypic heterogeneity. PMID:26316886

Performance Characterization and Optimization of Microgrid-Based Energy Generation and Storage Technologies

DTIC Science & Technology

2012-01-01

A. Rufer, “Multiphysics and energetic modeling of a vanadium redox flow battery ,” in Proc. 2008 IEEE International Conference on Sustainable...p. 81. [11] K.W. Knehr and E.C. Kumbur, "Open circuit voltage of vanadium redox flow batteries : Discrepancy between models and experiments...Blanc and A. Rufer, “Multiphysics and energetic modeling of a vanadium redox flow battery ,” in Proc. 2008 IEEE International Conference on Sustainable

ITC/USA/'90; Proceedings of the International Telemetering Conference, Las Vegas, NV, Oct. 29-Nov. 2, 1990

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1990-01-01

This conference presents papers in the fields of airborne telemetry, measurement technology, video instrumentation and monitoring, tracking and receiving systems, and real-time processing in telemetry. Topics presented include packet telemetry ground station simulation, a predictable performance wideband noise generator, an improved drone tracking control system transponder, the application of neural networks to drone control, and an integrated real-time turbine engine flight test system.

Interwell exciton dispersion engineering, coherent phonons generation and optical detectionof exciton condensate

NASA Astrophysics Data System (ADS)

Hildebrandt, Stefan

2004-01-01

Conference Reports are meant to offer an authoritative view on a recently held scientific meeting rather than a comprehensive list of the conference presentations. Authors are invited to describe what they feel were the most interesting contributions.Changing the culture of science and publication was the tenor at the IUPAP Workshop on Scientific Misconduct and the Role of Physics Journals in its Investigation and Prevention, recently held in London.

Research-Teaching Linkages: Practice and Policy. Proceedings of the Third Annual Conference of the National Academy for the Integration of Research, Teaching and Learning (3rd, Dublin, Ireland, November 11-12, 2009)

ERIC Educational Resources Information Center

Murphy, Jennifer, Ed.; Griffin, Carrie, Ed.; Higgs, Bettie, Ed.

2010-01-01

The third annual conference of the National Academy for Integration of Research, Teaching and Learning (NAIRTL) was held at Trinity College Dublin on 11-12 November 2009, and was attended by over 300 delegates. The theme--"Research-Teaching Linkages: Practice and Policy"--was timely and generated some fascinating papers, workshops and…

Scientific program and abstracts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gerich, C.

1983-01-01

The Fifth International Conference on High-Power Particle Beams is organized jointly by the Lawrence Livermore National Laboratory and Physics International Company. As in the previous conferences in this series, the program includes the following topics: high-power, electron- and ion-beam acceleration and transport; diode physics; high-power particle beam interaction with plasmas and dense targets; particle beam fusion (inertial confinement); collective ion acceleration; particle beam heating of magnetically confined plasmas; and generation of microwave/free-electron lasers.

Proceedings of the Fifth Integrated Communications, Navigation, and Surveillance (ICNS) Conference and Workshop

NASA Technical Reports Server (NTRS)

Fujikawa, Gene (Compiler)

2005-01-01

Contents includes papers on the following: JPDO: Inter-Agency Cooperation for the Next Generation ATS; R&T Programs; Integrated CNS Systems and Architectures; Datalink Communication Systems; Navigation, System Demonstrations and Operations; Safety and Security Initiatives Impacting CNS; Global Communications Initiatives; Airborne Internet; Avionics for System-Level Enhancements; SWIM (System Wide Information Management); Weather Products and Data Dissemination Technologies; Airsapce Communication Networks; Surveillance Systems; Workshop Breakouts Sessions and ; ICNS Conference Information.

Security Games Applied to Real-World: Research Contributions and Challenges

DTIC Science & Technology

2012-01-01

Marecki, J.: GUARDS and PROTECT: Next Generation Applications of Security Games . SIGECOM 10 (March 2011) 31–34 4. Shieh, E ., An, B., Yang, R., Tambe...Steigerwald, E .: GUARDS - Game Theoretic Security Allocation on a National Scale. In: Proc. of The 10th International Conference on Autonomous Agents...Shieh, E ., Kiekintveld, C.: Refinement of Strong Stackelberg Equilibria in Security Games . In: Proc. of the 25th Conference on Artificial Intelligence

26 CFR 26.6081-1 - Automatic extension of time for filing generation-skipping transfer tax returns.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 14 2011-04-01 2010-04-01 true Automatic extension of time for filing generation-skipping transfer tax returns. 26.6081-1 Section 26.6081-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) ESTATE AND GIFT TAXES GENERATION-SKIPPING TRANSFER TAX...

26 CFR 26.6081-1 - Automatic extension of time for filing generation-skipping transfer tax returns.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 14 2010-04-01 2010-04-01 false Automatic extension of time for filing generation-skipping transfer tax returns. 26.6081-1 Section 26.6081-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) ESTATE AND GIFT TAXES GENERATION-SKIPPING TRANSFER TAX...

26 CFR 26.6081-1 - Automatic extension of time for filing generation-skipping transfer tax returns.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 26 Internal Revenue 14 2013-04-01 2013-04-01 false Automatic extension of time for filing generation-skipping transfer tax returns. 26.6081-1 Section 26.6081-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) ESTATE AND GIFT TAXES GENERATION-SKIPPING TRANSFER TAX...

26 CFR 26.6081-1 - Automatic extension of time for filing generation-skipping transfer tax returns.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 26 Internal Revenue 14 2014-04-01 2013-04-01 true Automatic extension of time for filing generation-skipping transfer tax returns. 26.6081-1 Section 26.6081-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) ESTATE AND GIFT TAXES GENERATION-SKIPPING TRANSFER TAX...

26 CFR 26.6081-1 - Automatic extension of time for filing generation-skipping transfer tax returns.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 26 Internal Revenue 14 2012-04-01 2012-04-01 false Automatic extension of time for filing generation-skipping transfer tax returns. 26.6081-1 Section 26.6081-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) ESTATE AND GIFT TAXES GENERATION-SKIPPING TRANSFER TAX...

Protection conferred by recombinant Yersinia pestis antigens produced by a rapid and highly scalable plant expression system

PubMed Central

Santi, Luca; Giritch, Anatoli; Roy, Chad J.; Marillonnet, Sylvestre; Klimyuk, Victor; Gleba, Yuri; Webb, Robert; Arntzen, Charles J.; Mason, Hugh S.

2006-01-01

Plague is still an endemic disease in different regions of the world. Increasing reports of incidence, the discovery of antibiotic resistance strains, and concern about a potential use of the causative bacteria Yersinia pestis as an agent of biological warfare have highlighted the need for a safe, efficacious, and rapidly producible vaccine. The use of F1 and V antigens and the derived protein fusion F1-V has shown great potential as a protective vaccine in animal studies. Plants have been extensively studied for the production of pharmaceutical proteins as an inexpensive and scalable alternative to common expression systems. In the current study the recombinant plague antigens F1, V, and fusion protein F1-V were produced by transient expression in Nicotiana benthamiana by using a deconstructed tobacco mosaic virus-based system that allowed very rapid and extremely high levels of expression. All of the plant-derived purified antigens, administered s.c. to guinea pigs, generated systemic immune responses and provided protection against an aerosol challenge of virulent Y. pestis. PMID:16410352

Endoplasmic reticulum aminopeptidase 1 function and its pathogenic role in regulating innate and adaptive immunity in cancer and major histocompatibility complex class I-associated autoimmune diseases.

PubMed

Fruci, D; Romania, P; D'Alicandro, V; Locatelli, F

2014-08-01

Major histocompatibility complex (MHC) class I molecules present antigenic peptides on the cell surface to alert natural killer (NK) cells and CD8(+) T cells for the presence of abnormal intracellular events, such as virus infection or malignant transformation. The generation of antigenic peptides is a multistep process that ends with the trimming of N-terminal extensions in the endoplasmic reticulum (ER) by aminopeptidases ERAP1 and ERAP2. Recent studies have highlighted the potential role of ERAP1 in reprogramming the immunogenicity of tumor cells in order to elicit innate and adaptive antitumor immune responses, and in conferring susceptibility to autoimmune diseases in predisposed individuals. In this review, we will provide an overview of the current knowledge about the role of ERAP1 in MHC class I antigen processing and how its manipulation may constitute a promising tool for cancer immunotherapy and treatment of MHC class I-associated autoimmune diseases. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Increased Use of Twitter at a Medical Conference: A Report and a Review of the Educational Opportunities

PubMed Central

Cumming, Grant P; Lee, Amanda J

2012-01-01

Background Most consider Twitter as a tool purely for social networking. However, it has been used extensively as a tool for online discussion at nonmedical and medical conferences, and the academic benefits of this tool have been reported. Most anesthetists still have yet to adopt this new educational tool. There is only one previously published report of the use of Twitter by anesthetists at an anesthetic conference. This paper extends that work. Objective We report the uptake and growth in the use of Twitter, a microblogging tool, at an anesthetic conference and review the potential use of Twitter as an educational tool for anesthetists. Methods A unique Twitter hashtag (#WSM12) was created and promoted by the organizers of the Winter Scientific Meeting held by The Association of Anaesthetists of Great Britain and Ireland (AAGBI) in London in January 2012. Twitter activity was compared with Twitter activity previously reported for the AAGBI Annual Conference (September 2011 in Edinburgh). All tweets posted were categorized according to the person making the tweet and the purpose for which they were being used. The categories were determined from a literature review. Results A total of 227 tweets were posted under the #WSM12 hashtag representing a 530% increase over the previously reported anesthetic conference. Sixteen people joined the Twitter stream by using this hashtag (300% increase). Excellent agreement (κ = 0.924) was seen in the classification of tweets across the 11 categories. Delegates primarily tweeted to create and disseminate notes and learning points (55%), describe which session was attended, undertake discussions, encourage speakers, and for social reasons. In addition, the conference organizers, trade exhibitors, speakers, and anesthetists who did not attend the conference all contributed to the Twitter stream. The combined total number of followers of those who actively tweeted represented a potential audience of 3603 people. Conclusions This report demonstrates an increase in uptake and growth in the use of Twitter at an anesthetic conference and the review illustrates the opportunities and benefits for medical education in the future. PMID:23232765

Increased use of Twitter at a medical conference: a report and a review of the educational opportunities.

PubMed

McKendrick, Douglas R A; Cumming, Grant P; Lee, Amanda J

2012-12-11

Most consider Twitter as a tool purely for social networking. However, it has been used extensively as a tool for online discussion at nonmedical and medical conferences, and the academic benefits of this tool have been reported. Most anesthetists still have yet to adopt this new educational tool. There is only one previously published report of the use of Twitter by anesthetists at an anesthetic conference. This paper extends that work. We report the uptake and growth in the use of Twitter, a microblogging tool, at an anesthetic conference and review the potential use of Twitter as an educational tool for anesthetists. A unique Twitter hashtag (#WSM12) was created and promoted by the organizers of the Winter Scientific Meeting held by The Association of Anaesthetists of Great Britain and Ireland (AAGBI) in London in January 2012. Twitter activity was compared with Twitter activity previously reported for the AAGBI Annual Conference (September 2011 in Edinburgh). All tweets posted were categorized according to the person making the tweet and the purpose for which they were being used. The categories were determined from a literature review. A total of 227 tweets were posted under the #WSM12 hashtag representing a 530% increase over the previously reported anesthetic conference. Sixteen people joined the Twitter stream by using this hashtag (300% increase). Excellent agreement (κ = 0.924) was seen in the classification of tweets across the 11 categories. Delegates primarily tweeted to create and disseminate notes and learning points (55%), describe which session was attended, undertake discussions, encourage speakers, and for social reasons. In addition, the conference organizers, trade exhibitors, speakers, and anesthetists who did not attend the conference all contributed to the Twitter stream. The combined total number of followers of those who actively tweeted represented a potential audience of 3603 people. This report demonstrates an increase in uptake and growth in the use of Twitter at an anesthetic conference and the review illustrates the opportunities and benefits for medical education in the future.

Proceedings: 1990 fossil plant cycling conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-12-01

Fossil plant cycling continues to be a key issue for many electric utilities. EPRI's previous cycling workshops, held in 1983, 1985, and 1987, allowed utilities to benefit from collective industry experience in the conversion of baseload fossil units to cyclic operation. Continued improvements in equipment, retrofits, diagnostics, and controls were highlighted at the 1990 conference. The objective is to provide a forum for utility discussions of the cycling operation of fossil fuel power plants. Potomac Electric Power Company (PEPCO) hosted the 1990 EPRI Fossil Fuel Cycling Conference in Washington, DC, on December 4--6, 1990. More than 130 representatives from utilities,more » vendors, government agencies, universities, and industry associations attended the conference. Following the general session, technical sessions covered such topics as plant modifications, utility retrofit experience, cycling economics, life assessment, controls, environmental controls, and energy storage. Attendees also toured PEPCO's Potomac River generating station, the site of an earlier EPRI cycling conversion study.« less

Third generation anthropomorphic physical phantom for mammography and DBT: incorporating voxelized 3D printing and uniform chest wall QC region

NASA Astrophysics Data System (ADS)

Zhao, Christine; Solomon, Justin; Sturgeon, Gregory M.; Gehm, Michael E.; Catenacci, Matthew; Wiley, Benjamin J.; Samei, Ehsan; Lo, Joseph Y.

2017-03-01

Physical breast phantoms provide a standard method to test, optimize, and develop clinical mammography systems, including new digital breast tomosynthesis (DBT) systems. In previous work, we produced an anthropomorphic phantom based on 500x500x500 μm breast CT data using commercial 3D printing. We now introduce an improved phantom based on a new cohort of virtual models with 155x155x155 μm voxels and fabricated through voxelized 3D printing and dithering, which confer higher resolution and greater control over contrast. This new generation includes a uniform chest wall extension for evaluating conventional QC metrics. The uniform region contains a grayscale step wedge, chest wall coverage markers, fiducial markers, spheres, and metal ink stickers of line pairs and edges to assess contrast, resolution, artifact spread function, MTF, and other criteria. We also experimented with doping photopolymer material with calcium, iodine, and zinc to increase our current contrast. In particular, zinc was discovered to significantly increase attenuation beyond 100% breast density with a linear relationship between zinc concentration and attenuation or breast density. This linear relationship was retained when the zinc-doped material was applied in conjunction with 3D printing. As we move towards our long term goal of phantoms that are indistinguishable from patients, this new generation of anthropomorphic physical breast phantom validates our voxelized printing process, demonstrates the utility of a uniform QC region with features from 3D printing and metal ink stickers, and shows potential for improved contrast via doping.

Conference on Fire Resistant Materials (FIREMEN): A compilation of presentations and papers

NASA Technical Reports Server (NTRS)

Kourtides, D. A. (Editor)

1978-01-01

The proceedings of the NASA Fire Resistant Materials Engineering (FIREMEN) Program held at Ames Research Center on April, 13, 14, 1978 are reported. The purpose of the conference was to discuss the results of NASA in the field of aircraft fire safety and fire resistant materials. The program components include the following: (1) large-scale testing; (2) fire toxicology; (3) polymeric materials; and (4) bibliography related and/or generated from the program.

Youth in Transition: The Challenges of Generational Change in Asia. Proceedings of the Biennial General Conference of the Association of Asian Social Science Research Councils (15th, Canberra, Australia, 2005)

ERIC Educational Resources Information Center

Gale, Fay, Ed.; Fahey, Stephanie, Ed.

2005-01-01

This book originates from a conference of the Association of Asian Social Science Research Councils and contains writings and research reports on Youth in Transition in the Asia and Pacific region. The definition of "youth" varies from country to country and ranges between the ages of 10 to 35. The publication summarizes issues in the…

GLOBECOM '92 - IEEE Global Telecommunications Conference, Orlando, FL, Dec. 6-9, 1992, Conference Record. Vols. 1-3

NASA Astrophysics Data System (ADS)

Papers are presented on such topics as the wireless data network in PCS, advances in digital mobile networks, ATM switching experiments, broadband applications, network planning, and advances in SONET/SDH implementations. Consideration is also given to gigabit computer networks, techniques for modeling large high-speed networks, coding and modulation, the next-generation lightwave system, signaling systems for broadband ISDN, satellite technologies, and advances in standardization of low-rate signal processing.

Cells in Space

NASA Technical Reports Server (NTRS)

Sibonga, Jean D. (Editor); Mains, Richard C. (Editor); Fast, Thomas N. (Editor); Callahan, Paul X. (Editor); Winget, Charles M. (Editor)

1989-01-01

Discussions and presentations addressed three aspects of cell research in space: the suitability of the cell as a subject in microgravity experiments, the requirements for generic flight hardware to support cell research, and the potential for collaboration between academia, industry, and government to develop these studies in space. Synopses are given for the presentations and follow-on discussions at the conference and papers are presented from which the presentations were based. An Executive Summary outlines the recommendations and conclusions generated at the conference.

Bioavailable Concentrations of Delphinidin and Its Metabolite, Gallic Acid, Induce Antioxidant Protection Associated with Increased Intracellular Glutathione in Cultured Endothelial Cells

PubMed Central

Goszcz, Katarzyna; Deakin, Sherine J.; Duthie, Garry G.; Stewart, Derek

2017-01-01

Despite limited bioavailability and rapid degradation, dietary anthocyanins are antioxidants with cardiovascular benefits. This study tested the hypothesis that the antioxidant protection conferred by the anthocyanin, delphinidin, is mediated by modulation of endogenous antioxidant defences, driven by its degradation product, gallic acid. Delphinidin was found to degrade rapidly (t1/2 ~ 30 min), generating gallic acid as a major degradation product. Both delphinidin and gallic acid generated oxygen-centred radicals at high (100 μM) concentrations in vitro. In a cultured human umbilical vein endothelial cell model of oxidative stress, the antioxidant protective effects of both delphinidin and gallic acid displayed a hormesic profile; 100 μM concentrations of both were cytotoxic, but relatively low concentrations (100 nM–1 μM) protected the cells and were associated with increased intracellular glutathione. We conclude that delphinidin is intrinsically unstable and unlikely to confer any direct antioxidant activity in vivo yet it offered antioxidant protection to cells at low concentrations. This paradox might be explained by the ability of the degradation product, gallic acid, to confer benefit. The findings are important in understanding the mode of protection conferred by anthocyanins and reinforce the necessity to conduct in vitro experiments at biologically relevant concentrations. PMID:29081896

CTOL Transport Technology, 1978. [conferences

NASA Technical Reports Server (NTRS)

1978-01-01

Technology generated by NASA and specifically associated with advanced conventional takeoff and landing transport aircraft is reported. Topics covered include: aircraft propulsion; structures and materials; and laminar flow control.

Bibliography of Soviet Laser Developments, Number 58, March-April 1982.

DTIC Science & Technology

1983-05-01

generation and diagnostics . DD IA7 1473 EOITION OF I NOV A OSOLETE UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE (When Does Entered) Introduction...10 C. He-Kr............................................. 10 iv 2. Molecular Beam and lIon a. C02...104 K. Plasma Generation and Diagnostics ....................... 105 III. MONOGRAPHS, BOOKS, CONFERENCE PROCEEDINGS................... 113

75 FR 10860 - Announcement of a Meeting of the International Telecommunication Advisory Committee

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-09

... (ITU) Telecommunication Standardization Sector (ITU-T) Study Group 13 (Future networks including mobile and Next Generation Networks). The ITAC will meet by conference call to prepare advice for the U.S. government for the meeting of ITU-T Study Group 13 (Future networks including mobile and Next Generation...

Keynote: What Is the State of E-Learning? Reflections on 30 Ways Learning Is Changing

ERIC Educational Resources Information Center

Bonk, Curtis J.

2016-01-01

This paper is based on a keynote talk delivered at the biennial DEANZ Conference at the University of Waikato in Hamilton, New Zealand, in April 2016. As highlighted in that talk, we have entered Education 3.0--an age of vast resource abundance and extensive opportunities for learner empowerment. During the past decade, we have seen the emergence…

Foundations for Security Aware Software Development Education

DTIC Science & Technology

2005-11-22

depending on the budget, that support robustness. We discuss the educational customer base, projected lifetime, and complexity of paradigm shift that should...in Honour of Sir Tony Hoar, [6] Cheetham, C. and Ferraiolo, K., "The Systems Security Millenial Perspectives in Computer Science, Engineering...Capability Maturity Model", 21st 2002, 229-246. National Information Systems Security Conference, [15] Schwartz, J., "Object Oriented Extensions to October 5

10th Annual Small Business Conference

DTIC Science & Technology

2006-11-02

has extensive process knowledge in military, space and commercial. Steve worked many corporate initiatives, and led a leveraging group that made a...2001, Mr. Loehrl served as Chief of the Chemical Demilitarization program, a $ 12 billion mission that was new to the Command. His - 1 - - 1... Trivia Question Apple Trivia Question Focus Right Product Right Time Right Place Right Price Rapid Fielding Initiative Equipment Items Fielded to All

Non-timber forest products: local livelihoods and integrated forest management

Treesearch

Iain Davidson-Hunt; Luc C. Duchesne; John C. Zasada

2001-01-01

In October of 1999 a conference was held in Kenora, Ontario, Canada, to explore the non-timber forest products (NTFPs) of boreal and cold temperate forests. Up to this time, the concept of NTFP, was one that had been developed largely for tropical and subtropical forests. An extensive body of literature exists on a wide range of topics for the NTFPs of tropical and...

Proceedings of the Fourth Symposium on Conference on Dynamics of Cosmic Gases, Varenna Italy (Lake of Como), August 18-30, 1960; ATTI DEL IV SYMPOSIUM SULLA DINAMICA DEL GAS COSMICO, VARENNA SUL LAGO DI COMO 18-30 AGOSTO 1960

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1961-01-01

Fifteen papers are included: separate abstracts have been prepared for l0. A single abstract has been prepared to cover the remaining 5 papers, which consist of observational studies. Extensive discussions are included. (T.F.H.)

Family group conferences in public mental health care: an exploration of opportunities.

PubMed

de Jong, Gideon; Schout, Gert

2011-02-01

Family group conferences are usually organized in youth care settings, especially in cases of (sexual) abuse of children and domestic violence. Studies on the application of family group conferences in mental health practices are scarce, let alone in a setting even more specific, such as public mental health care. The present study reports on an exploratory study on the applicability of family group conferencing in public mental health care. Findings suggest that there are six reasons to start family group conference pilots in public mental health care. First, care providers who work in public mental health care often need to deal with clients who are not motivated in seeking help. Family group conferences could yield support or provide a plan, even without the presence of the client. Second, conferences might complement the repertoire of treatment options between voluntary help and coercive treatment. Third, clients in public mental health care often have a limited network. Conferences promote involvement, as they expand and restore relationships, and generate support. Fourth, conferences could succeed both in a crisis and in other non-critical situations. Sometimes pressure is needed for clients to accept help from their network (such as in the case of an imminent eviction), while in other situations, it is required that clients are stabilized before a conference can be organized (such as in the case of a psychotic episode). Fifth, clients who have negative experiences with care agencies and their representatives might be inclined to accept a conference because these agencies act in another (modest) role. Finally, the social network could elevate the work of professionals. © 2011 The Authors. International Journal of Mental Health Nursing © 2011 Australian College of Mental Health Nurses Inc.

Compound mutations in BCR-ABL1 are not major drivers of primary or secondary resistance to ponatinib in CP-CML patients

PubMed Central

Hodgson, J. Graeme; Shah, Neil P.; Cortes, Jorge E.; Kim, Dong-Wook; Nicolini, Franck E.; Talpaz, Moshe; Baccarani, Michele; Müller, Martin C.; Li, Jin; Parker, Wendy T.; Lustgarten, Stephanie; Clackson, Tim; Haluska, Frank G.; Guilhot, Francois; Kantarjian, Hagop M.; Soverini, Simona; Hochhaus, Andreas; Hughes, Timothy P.; Rivera, Victor M.; Branford, Susan

2016-01-01

BCR-ABL1 kinase domain mutations can confer resistance to first- and second-generation tyrosine kinase inhibitors (TKIs) in chronic myeloid leukemia (CML). In preclinical studies, clinically achievable concentrations of the third-generation BCR-ABL1 TKI ponatinib inhibit T315I and all other single BCR-ABL1 mutants except T315M, which generates a single amino acid exchange, but requires 2 sequential nucleotide exchanges. In addition, certain compound mutants (containing ≥2 mutations in cis) confer resistance. Initial analyses based largely on conventional Sanger sequencing (SS) have suggested that the preclinical relationship between BCR-ABL1 mutation status and ponatinib efficacy is generally recapitulated in patients receiving therapy. Thus far, however, such analyses have been limited by the inability of SS to definitively identify compound mutations or mutations representing less than ∼20% of total alleles (referred to as “low-level mutations”), as well as limited patient follow-up. Here we used next-generation sequencing (NGS) to define the baseline BCR-ABL1 mutation status of 267 heavily pretreated chronic phase (CP)-CML patients from the PACE trial, and used SS to identify clonally dominant mutants that may have developed on ponatinib therapy (30.1 months median follow-up). Durable cytogenetic and molecular responses were observed irrespective of baseline mutation status and included patients with compound mutations. No single or compound mutation was identified that consistently conferred primary and/or secondary resistance to ponatinib in CP-CML patients. Ponatinib is effective in CP-CML irrespective of baseline mutation status. PMID:26603839

Report to the International Global Atmospheric Chemistry Project

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reisdorf, Jill; Wiedinmyer, Christine

IGAC’s mission is to facilitate atmospheric chemistry research towards a sustainable world. This is achieved through IGAC’s three focal activities: fostering community, building capacity, and providing leadership. A key component to achieving IGAC’s mission is its developing early career program. These scientists join an international network early in their career that puts the cogs in motion to further facilitate atmospheric chemistry research at an international level for years to come. IGAC’s Science Conference is a primary mechanism for IGAC to build cooperation and disseminate scientific information across its international community. The first IGAC Science Conference was held in 1993 in Eilat,more » Israel. Since then, IGAC has successfully held fourteen science conferences, consistently becoming a biennial conference starting in 2002. The biennial IGAC Science Conference is regarded as THE international conference on atmospheric chemistry and participation in the conference is typically in the range of 350-650 participants. Since 2004, IGAC has included an Early Career Scientists Program as part of the conference to foster the next generation of scientists. IGAC believes, and has seen, that by allowing scientists to form an international network of colleagues early in their career that future international collaborations in atmospheric chemistry are enhanced. The 2016 IGAC Science Conference Early Career Program consisted of numerous events throughout the week giving these scientists the opportunity to not only create a community amongst themselves, but to also engage and build relationships with senior scientists. In order to support the Early Career Scientists Program, IGAC sought funding from international, regional and local organizations to provide Travel Grants to the conference based on an assessment of both need and merit. This conference summary reports on outcomes of the 2016 IGAC Science Conference and the Early Career Program, which included early career travel grants funded by this DOE grant.« less

[Book review] Waterfowl ecology and management: Selected readings

USGS Publications Warehouse

Krapu, Gary L.

1983-01-01

This book is a compilation of papers from the extensive and varied published literature on the ecology and management of waterfowl. The 125 technical papers reprinted in this book are arranged in eight major sections and are from 21 journals, government reports, several books, and proceedings of symposia and annual conferences. The most frequent sources of papers are The Journal of Wildlife Management, The Auk, Transactions North American Wildlife and Natural Resources Conference, and Wildfowl. These readings span the period from 1937 through 1981. A majority of the technical papers was published during the sixties and seventies, reflecting the expansion of waterfowl research during that period. The front cover and the introductory page of each section are illustrated with black-and-white drawings of North American waterfowl by D. R. Barrick.

mTOR Signaling Confers Resistance to Targeted Cancer Drugs.

PubMed

Guri, Yakir; Hall, Michael N

2016-11-01

Cancer is a complex disease and a leading cause of death worldwide. Extensive research over decades has led to the development of therapies that target cancer-specific signaling pathways. However, the clinical benefits of such drugs are at best transient due to tumors displaying intrinsic or adaptive resistance. The underlying compensatory pathways that allow cancer cells to circumvent a drug blockade are poorly understood. We review here recent studies suggesting that mammalian TOR (mTOR) signaling is a major compensatory pathway conferring resistance to many cancer drugs. mTOR-mediated resistance can be cell-autonomous or non-cell-autonomous. These findings suggest that mTOR signaling should be monitored routinely in tumors and that an mTOR inhibitor should be considered as a co-therapy. Copyright © 2016 Elsevier Inc. All rights reserved.

European and Americas Committees for Treatment and Research in Multiple Sclerosis (ECTRIMS/ACTRIMS) - 7th Joint Triennial Congress (October 25-28, 2017 - Paris, France).

PubMed

Díaz, N

2017-10-01

The 7th Triennial Joint conference of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) was held in Paris, France. The meeting brought together attendees from a wide range of disciplines involved in multiple sclerosis (MS) research to explore an extensive program of teaching courses, plenary lectures, oral and poster sessions from approximately 2,000 abstracts submitted, and hot topic and young investigator presentations. These presentations covered topics including diagnostics, therapeutics and biomarkers, as well as a special section for MS nurses. Industry-sponsored symposia were also held. The report from this conference covers the latest developments in MS treatments.

Southern California Drosophila Conference: Irvine, CA - September 11, 2009.

PubMed

Rattner, Barbara P

2009-01-01

As has become tradition, this year's Southern California Drosophila Conference was hosted by the Developmental Biology Center (http://dbc.bio.uci.edu/) at the University of California, Irvine. On September 11, 2009, speakers from institutions in Los Angeles, Orange, Riverside, and San Diego Counties presented their latest results in an informal and friendly atmosphere and had the opportunity to learn about new resources and facilities, establish collaborations, and network about job openings and training opportunities. The talks presented covered the use of flies to study a variety of topics including the mechanisms of action of human pathogens, human diseases, and aging and lifespan extension. In addition, attendees heard about aspects of Drosophila neuronal development, olfactory behavior, transcriptional regulation, and signal transduction. Some of the highlights of the meeting are summarized in this brief report.

Progress in passive solar energy systems. Volume 8. Part 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hayes, J.; Andrejko, D.A.

1983-01-01

This book presents the papers given at a conference sponsored by the US DOE, the Solar Energy Research Institute, SolarVision, Inc., and the Southern California Solar Energy Society. The topics considered at the conference included sizing solar energy systems for agricultural applications, a farm scale ethanol production plant, the EEC wind energy RandD program, the passive solar performance assessment of an earth-sheltered house, the ARCO 1 MW photovoltaic power plant, the performance of a dendritic web photovoltaic module, second generation point focused concentrators, linear fresnel lens concentrating photovoltaic collectors, photovoltaic conversion efficiency, amorphous silicon thin film solar cells, a photovoltaicmore » system for a shopping center, photovoltaic power generation for the utility industry, spectral solar radiation, and the analysis of insolation data.« less

The Second Annual International Space University Alumni Conference

NASA Technical Reports Server (NTRS)

Johnson, Les (Compiler); Robinson, Paul A. (Compiler)

1994-01-01

The papers presented at the conference reflect the multidisciplinary nature of the International Space University (ISU) and its alumni. The first papers presented hold special relevance to the design projects, and cover such topics as lunar-based astronomical instrumentation, solar lunar power generation, habitation on the moon, and the legal issues governing multinational astronauts conducting research in space. The next set of papers cover various technical issues such as project success assessment, satellite networks and space station dynamics, thus reflecting the diverse backgrounds of the ISU alumni.

NASA Computational Fluid Dynamics Conference. Volume 1: Sessions 1-6

NASA Technical Reports Server (NTRS)

1989-01-01

Presentations given at the NASA Computational Fluid Dynamics (CFD) Conference held at the NASA Ames Research Center, Moffett Field, California, March 7-9, 1989 are given. Topics covered include research facility overviews of CFD research and applications, validation programs, direct simulation of compressible turbulence, turbulence modeling, advances in Runge-Kutta schemes for solving 3-D Navier-Stokes equations, grid generation and invicid flow computation around aircraft geometries, numerical simulation of rotorcraft, and viscous drag prediction for rotor blades.

Special coverage: 9th Conference on Retroviruses. New drugs, new data hold promise for next decade of HIV treatment.

PubMed

2002-05-01

Antiretroviral research presented recently at the 9th Conference on Retroviruses and Opportunistic Infections demonstrates that investigators and pharmaceutical companies continue to strive for the next highly potent and easily tolerated anti-HIV drug. Among the new approaches are entry inhibitor drug and second-generation non-nucleoside reverse transcriptase inhibitors. New studies also looked into potency against multidrug-resistant virus and medication regimens that are simpler to take and have fewer side effects.

Extensions to the Parallel Real-Time Artificial Intelligence System (PRAIS) for fault-tolerant heterogeneous cycle-stealing reasoning

NASA Technical Reports Server (NTRS)

Goldstein, David

1991-01-01

Extensions to an architecture for real-time, distributed (parallel) knowledge-based systems called the Parallel Real-time Artificial Intelligence System (PRAIS) are discussed. PRAIS strives for transparently parallelizing production (rule-based) systems, even under real-time constraints. PRAIS accomplished these goals (presented at the first annual C Language Integrated Production System (CLIPS) conference) by incorporating a dynamic task scheduler, operating system extensions for fact handling, and message-passing among multiple copies of CLIPS executing on a virtual blackboard. This distributed knowledge-based system tool uses the portability of CLIPS and common message-passing protocols to operate over a heterogeneous network of processors. Results using the original PRAIS architecture over a network of Sun 3's, Sun 4's and VAX's are presented. Mechanisms using the producer-consumer model to extend the architecture for fault-tolerance and distributed truth maintenance initiation are also discussed.

Mutation of C. elegans demethylase spr-5 extends transgenerational longevity

PubMed Central

Greer, Eric Lieberman; Becker, Ben; Latza, Christian; Antebi, Adam; Shi, Yang

2016-01-01

Complex organismal properties such as longevity can be transmitted across generations by non-genetic factors. Here we demonstrate that deletion of the C. elegans histone H3 lysine 4 dimethyl (H3K4me2) demethylase, spr-5, causes a trans-generational increase in lifespan. We identify a chromatin-modifying network, which regulates this lifespan extension. We further show that this trans-generational lifespan extension is dependent on a hormonal signaling pathway involving the steroid dafachronic acid, an activator of the nuclear receptor DAF-12. These findings suggest that loss of the demethylase SPR-5 causes H3K4me2 mis-regulation and activation of a known lifespan-regulating signaling pathway, leading to trans-generational lifespan extension. PMID:26691751

Tapping into the wisdom in the room: results from participant discussion at the 7th International Conference on Diagnostic Error in Medicine facilitated by a World Café technique.

PubMed

Cosby, Karen S; Zipperer, Lorri; Balik, Barbara

2015-09-01

The patient safety literature is full of exhortations to approach medical error from a system perspective and seek multidisciplinary solutions from groups including clinicians, patients themselves, as well as experts outside the traditional medical domain. The 7th annual International Conference on Diagnostic Error in Medicine sought to attract a multispecialty audience, and attempted to capture some of the conversations by engaging participants in a World Café, a technique used to stimulate discussion and preserve insight gained during the conference. We present the ideas generated in this session, discuss them in the context of psychological safety, and demonstrate the application of this novel technique.

Military Energy Alternatives Conference

DTIC Science & Technology

2012-03-08

Power Generation and Alternative Energy Branch US Army RDECOM CERDEC CP&ID Power Division Aberdeen Proving Ground, MD...Co-generation Applications •Tactical Mobile Power •Vehicle-mounted Auxiliary Power and Environmental Control •Energy Security for Base...Mobile Power (PM MEP / PM CP) Vehicle Power (PM Tactical Vehicle / PM HTV) Portable Solar Photovoltaic (PV) Modules and Mobile Hybrid PV Power Sources

U.S. Department of Energy awards $200 million for next-generation

Science.gov Websites

build a powerful new next-gen supercomputer, Aurora. The press conference took place at Chicago tech Congress and industry at the announcement of DOE's award of $200 million to Argonne in order to build a accelerate to next-generation exascale computing. DOE earlier announced a $325 million investment to build

PREFACE: 1982 International Conference on Plasma Physics

NASA Astrophysics Data System (ADS)

Wilhelmsson, Hans

1982-01-01

Invited Papers: The Physics of Hot Plasmas During the last decade a dramatic evolution of plasma physics has occurred. Not only have gigantic fusion plasma machines been planned, and are now being built, and elaborate spaceships and antenna systems been constructed to explore remote parts of the cosmos; new observations have revealed fascinating structures in space, ranging from pulsar plasmas under extreme conditions in very strong magnetic fields to large-scale magnetic field and electric current systems in cosmic plasmas. X-rays from very distant sources as well as radio-waves from the plasma in the magnetosphere and in the Aurora have recently been studied with new observational techniques. Ingenious laboratory experiments are continuously being carried out to exploit new fundamental processes in plasmas. These are of great interest for the basic understanding of plasmas and also have immediate consequences for applications, like plasma heating and diagnostics. The theoretical description of new plasma phenomena, and of the plasma state in general poses challenging problems, particularly in situations where high concentration of energy is located in the plasmas. Nonlinear wave analysis and turbulence theory have accordingly been extensively developed to describe in particular the collective plasma phenomena. New concepts have been envisaged like plasma solitons, which may be thought of as excitations of local concentrations of longitudinal plasma waves which turn out to be particularly stable. More and more sophisticated structures of nonlinear nature are being revealed by means of high capacity computer facilities. Simulation experiments allow for studies of chaotic behaviour of plasma particles. Related fields of activity form new trends in the development of plasma theory. The programme of the 1982 International Conference on Plasma Physics, which was held in Göteborg, Sweden, stressed the role of the Physics of Hot Plasmas. Studies of such plasmas are essential, not only for fusion energy development, but also for astro- and space research. Plasmas in different situations often have important features in common. Results obtained under various conditions, in the laboratory or in space, should therefore be compared and interrelated. The Göteborg conference emphasized more than the previous one, which was held in Nagoya, Japan, the astro- and space aspects, but there were still more contributions from the fusion and laboratory research. The fundamental plasma theory part was, however, the most extensive one in the programme. At the conference there were seventy invited talks, including six comprehensive talks addressed to all participants. The remaining sixtyfour invited talks were topical talks. Besides, we had received about 450 contributed papers. About 300 of them were given as posters, and most of the remaining ones were presented as orals. The set of one page abstracts of these contributed papers as well as the titles of the invited talks were collected in two volumes, which were sent to all participants a month before the conference. Another set, the four page papers, which had been carefully prepared by the authors for photoreproduction to one page papers, were published in a volume of proceedings of some 460 pages available at the conference. When trying to classify the contributions, it turned out that they fell naturally into four main categories, namely: General Theory Space and Astro Plasmas Fusion Laboratory Plasmas For practical reasons we had to divide the Abstracts into two Volumes, the first one including categories (1) and (2), and the second one the two remaining categories (3) and (4). In publishing the invited talks from the conference we had to handle a great number of extensive papers. It turned out to be natural to have also the invited papers published in two parts, as two separate numbers of Physica Scripta, the first one devoted to (1) General Theory, and (2) Space and Astro Plasmas, whereas the second one to (3) Fusion and (4) Laboratory Plasmas. The 1982 International Conference on Plasma Physics was organized by Chalmers University of Technology. It gathered about 500 participants from 40 countries. Large delegations came from the USA, France, West Germany, Japan, the USSR, and India, the number of participants from these countries ranging from 100 to 20. Sweden had about 50 participating scientists. There were a total of about 20 from the other Scandinavian countries. The principal sponsor of the conference was IUPAP, the International Union of Pure and Applied Physics. The conference also had a number of co-sponsors like IAU, the International Astronomical Union, URSI, the International Union of Radio Science, EPS, the European Physical Society, and EURATOM-FUSION. The conference was supported by Swedish Industry and Swedish Research Boards. The previous ICPP, held in Nagoya two years ago, was the first attempt to combine two types of conferences: the Plasma Theory Conference, first held in Kiev in the Soviet Union in 1971, and the Waves and Instabilities Congress, held for the first time in Innsbruck, Austria in 1973. As a consequence of the success of the Nagoya conference it was decided by the International Organizing Committee of the ICPP that the 1982 conference should also be of the combined type. The 1982 ICPP in Göteborg was thus a Joint Conference of the Fifth Kiev International Conference in Plasma Theory and the Fifth International Congress on Waves and Instabilities in Plasmas. During the conference in Göteborg the International Organizing Committee had a meeting and it was decided that also the next International Conference on Plasma Physics will be of the combined type. It will be held in Lausanne, Switzerland in 1984. The International Organizing Committee on the 1982 International Conference on Plasma Physics comprised about 40 plasma physics scientists from all over the world, who represented various sections of plasma physics. I would like to thank the active members of the IOC for an efficient and friendly co-operation in deciding about the program of invited speakers and for discussions on the general structure of the conference. Our most cordial thanks are extended to the invited speakers for coming to the conference to deliver such excellent talks and to provide us in good time for printing with so beautifully prepared manuscripts. Symposium on Plasma Theory: Preface Several satellite meetings were arranged following the 1982 International Conference on Plasma Physics in Göteborg. Among them a Symposium on Plasma Theory was held at Aspenäsgården outside Göteborg during three days, June 16-18, 1982. The purpose of the symposium was to discuss problems of current interest in plasma theory with applications to space and astrophysical plasmas as well as to fusion plasmas. A total of fifteen talks were given during the three days, and some very lively discussions arose, notably in the area of plasma turbulence. There were around 30 invited scientists present, about one third from the United States, one third from the Soviet Union, and the rest from England, Japan, and various other countries. This volume of Physica Scripta (2B, 506-595) includes some of the talks which were given at Aspenäsgården. Several of the authors of contributed papers to the 1982 International Conference on Plasma Physics were encouraged to write extended versions of their contributions, and these are also included in this number, as are furthermore some papers, which were prepared during prolonged stays of visiting scientists at our institute in connection with the 1982 ICPP. It is expected that the collection of papers thus assembled will give a general picture of the activities accompanying the main conference and that it will elucidate some trends in the development of plasma theory.

Building the Next Generation of Earth Scientists: the Deep Carbon Observatory Early Career Scientist Workshops

NASA Astrophysics Data System (ADS)

Pratt, K.; Fellowes, J.; Giovannelli, D.; Stagno, V.

2016-12-01

Building a network of collaborators and colleagues is a key professional development activity for early career scientists (ECS) dealing with a challenging job market. At large conferences, young scientists often focus on interacting with senior researchers, competing for a small number of positions in leading laboratories. However, building a strong, international network amongst their peers in related disciplines is often as valuable in the long run. The Deep Carbon Observatory (DCO) began funding a series of workshops in 2014 designed to connect early career researchers within its extensive network of multidisciplinary scientists. The workshops, by design, are by and for early career scientists, thus removing any element of competition and focusing on peer-to-peer networking, collaboration, and creativity. The successful workshops, organized by committees of early career deep carbon scientists, have nucleated a lively community of like-minded individuals from around the world. Indeed, the organizers themselves often benefit greatly from the leadership experience of pulling together an international workshop on budget and on deadline. We have found that a combination of presentations from all participants in classroom sessions, professional development training such as communication and data management, and field-based relationship building and networking is a recipe for success. Small groups within the DCO ECS network have formed; publishing papers together, forging new research directions, and planning novel and ambitious field campaigns. Many DCO ECS also have come together to convene sessions at major international conferences, including the AGU Fall Meeting. Most of all, there is a broad sense of camaraderie and accessibility within the DCO ECS Community, providing the foundation for a career in the new, international, and interdisciplinary field of deep carbon science.

PREFACE Preface

NASA Astrophysics Data System (ADS)

Bleicher, Markus; Caines, Helen; Calderon de la Barca Sanchez, Manuel; de Falco, Alessandro; Fries, Rainer; Granier de Cassagnac, Raphael; Hippolyte, Boris; Mischke, Andre; Nardi, Marzia; Salgado, Carlos A.

2011-01-01

The 4th Workshop for Young Scientists on the Physics of Ultrarelativistic Nucleus-nucleus Collisions (Hot Quarks 2010) was held in La Londe-Les-Maures, France, from June 21-26, 2010. Following the traditions of the conference, this meeting gathered more than 70 participants in the first years of their scientific careers. The present issue contains the proceedings of this workshop. The articles published in this volume clearly show the presence of a dynamic new generation of physicists interested in the different aspects of high energy nuclear collisions. The newest results from RHIC at Brookhaven and SPS at CERN were presented, as well as the latest results from the proton-proton programme from the LHC at CERN, while waiting for the data of the lead-lead collisions only available some months after the meeting. Along with these experimental findings, the corresponding theoretical research was also extensively discussed as well as the new perspectives for future facilities like FAIR, EIC and LHeC. We wish to thank the sponsors of the Hot Quarks 2010 Conference, who supported the authors of this volume: IN2P3/CNRS (France), EMMI (Germany), Institut Pluridisciplinaire Hubert Curien (France), National Science Foundation (USA), CERN (Switzerland), Helmholtz International Center for FAIR (Germany), Xunta de Galicia (Spain) and the Journal of Physics G. Markus Bleicher (Frankfurt (HIC4FAIR), Germany)Helen Caines (Yale University, USA)Manuel Calderon de la Barca Sanchez (UC Davis, USA)Alessandro de Falco (Cagliari/INFN, Italy)Rainer Fries (Texas A & M University, USA) Raphael Granier de Cassagnac (Ecole Polytechnique, France)Boris Hippolyte (IPHC, Strasbourg, France)Andre Mischke (Utrecht University, The Netherlands)Marzia Nardi (Torino/INFN, Italy)Carlos A Salgado (Universidade de Santiago de Compostela, Galicia, Spain)

Generation of Trichoderma atroviride mutants with constitutively activated G protein signaling by using geneticin resistance as selection marker.

PubMed

Gruber, Sabine; Omann, Markus; Rodrìguez, Carolina Escobar; Radebner, Theresa; Zeilinger, Susanne

2012-11-17

Species of the fungal genus Trichoderma are important industrial producers of cellulases and hemicellulases, but also widely used as biocontrol agents (BCAs) in agriculture. In the latter function Trichoderma species stimulate plant growth, induce plant defense and directly antagonize plant pathogenic fungi through their mycoparasitic capabilities. The recent release of the genome sequences of four mycoparasitic Trichoderma species now forms the basis for large-scale genetic manipulations of these important BCAs. Thus far, only a limited number of dominant selection markers, including Hygromycin B resistance (hph) and the acetamidase-encoding amdS gene, have been available for transformation of Trichoderma spp. For more extensive functional genomics studies the utilization of additional dominant markers will be essential. We established the Escherichia coli neomycin phosphotransferase II-encoding nptII gene as a novel selectable marker for the transformation of Trichoderma atroviride conferring geneticin resistance. The nptII marker cassette was stably integrated into the fungal genome and transformants exhibited unaltered phenotypes compared to the wild-type. Co-transformation of T. atroviride with nptII and a constitutively activated version of the Gα subunit-encoding tga3 gene (tga3Q207L) resulted in a high number of mitotically stable, geneticin-resistant transformants. Further analyses revealed a co-transformation frequency of 68% with 15 transformants having additionally integrated tga3Q207L into their genome. Constitutive activation of the Tga3-mediated signaling pathway resulted in increased vegetative growth and an enhanced ability to antagonize plant pathogenic host fungi. The neomycin phosphotransferase II-encoding nptII gene from Escherichia coli proved to be a valuable tool for conferring geneticin resistance to the filamentous fungus T. atroviride thereby contributing to an enhanced genetic tractability of these important BCAs.

Fusion 2.0: The Next Generation of Fusion in California: Aligning State and Regional Fusion Centers

DTIC Science & Technology

2010-03-01

bible ” for fusion center management, as evidenced by the theme of the 2009 National Fusion Center Conference; appropriately called “Achieving Baseline...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS FUSION 2.0: THE NEXT GENERATION OF FUSION IN CALIFORNIA: ALIGNING STATE AND...Master’s Thesis 4. TITLE AND SUBTITLE Fusion 2.0: The Next Generation of Fusion in California: Aligning State and Regional Fusion

Analysis of Alternative Extensions of the Existing Production Tax Credit for Wind Generators

EIA Publications

2007-01-01

Requestor: Ms. Janice Mays, Chief Counsel, Committee on Ways & Means, U.S. House of Representatives This is a letter response requesting analysis of alternative extensions of the existing production tax credit (PTC) that would apply to wind generators only.

The Role of the Computer in Education. Proceedings of the Annual Meeting (6th, Arlington Heights, Illinois, February 12-14, 1986).

ERIC Educational Resources Information Center

Micro-Ideas, Glenview, IL.

Fifty-five papers focusing on the role of computer technology in education at all levels are included in the proceedings of this conference, which was designed to model effective and appropriate uses of the computer as an extension of the teacher-based instructional system. The use of the computer as a tool was emphasized, and the word processor…

Economic Productivity and Adaptability: Four State-of-the-Art Papers on the Highest Research Extension Priorities within the Twelve States and D.C. Northeast Region. Publication 60.

ERIC Educational Resources Information Center

Northeast Regional Center for Rural Development, University Park, PA.

Four commissioned papers prepared for a conference on key concepts in the areas of economic productivity and adaptability in the Northeastern states are presented in this document. These papers reflect an important fact: that major socioeconomic changes are underway that will affect the ability of Northeastern states to maintain productive and…

Generic Tasks for Knowledge-Based Problem Solving: Extension and New Directions

DTIC Science & Technology

1991-02-01

Report. i 3] D. Brown and B. Chandrasekaran. Design: An information processing level analy- sis. In Design Problem Solving: Knowledge Structures and...generic information processing tasks. In Proceedings of the Internaoional Joint Conference on Artificial Inte!lzjence. IJCAI, 1987. [181 B...Chandrasekaran. What kind of information processing is intelligence? a perspective I on ai paradigms and a proposal. In D. Partridge and Y. Wilks, editors

Toughness and Matching Extension in Graphs,

DTIC Science & Technology

1986-05-01

New York, 1977. V. CHVATAL 1973a. Tough graphs and Hamiltonian circuits, Discrete Math . 5, 1973, 215- 228. 1973b. New directions in Hamiltonian...PLUMMER 1986. Matching Theory, Ann. Discrete Math ., North-Holland, Amsterdam, 1986 (to appear). M. D. PLUMMER 1980. On n-extendable graphs, Discrete ... Math . 31, 1980, 201-210. 1985. A theorem on matchings in the plane, Conference in memory of Gabriel Dirac, Ann. Discrete Math ., North-Holland, Amsterdam

Proceedings of the 2006 Toxicology and Risk Assessment Conference: Applying Mode of Action in Risk Assessment

DTIC Science & Technology

2006-07-01

physiologically-based pharmacokinetic modeling of interactions and multiple route exposure assessment; and integrating relative potency factors with response...defaults, while at the other end is the use of extensive chemical-specific data in physiologically based pharmacokinetic (PBPK) modeling or even...for internal dosimetry as well as an in depth prospective on the use and limitations of physiologically based pharmacokinetic (PBPK) models in

Learn from the burn: The High Park Fire 5 years later

Treesearch

Sue Miller; Charles Rhodes; Pete Robichaud; Sandra Ryan; Jen Kovecses; Carl Chambers; Sara Rathburn; Jared Heath; Stephanie Kampf; Codie Wilson; Dan Brogan; Brad Piehl; Mary Ellen Miller; John Giordanengo; Erin Berryman; Monique Rocca

2017-01-01

It has been 5 years since the High Park Fire burned over 85,000 acres in Northern Colorado, causing extensive property damage, loss of life, and severe impacts to the water quality of the Poudre River. In the fall of 2016, a conference was organized by the USFS Rocky Mountain Research Station and the Coalition for the Poudre River Watershed to discuss what has been...

Celebrating the Power of Literacy. The Twenty-Sixth Yearbook: A Peer Reviewed Publication of The College Reading Association [Papers from the College Reading Association Conference, 2004

ERIC Educational Resources Information Center

Dugan, Jo Ann R., Ed.; Linder, Patricia E., Ed.; Sampson, Mary Beth, Ed.; Brancato, Barrie A., Ed.

2004-01-01

This Yearbook begins with Robert J. Rickelman's presidential speech, "Predicting the Whether: Lessons Learned from the Past," which focused on looking at the "History of the College Reading Association" in order to predict some possible (the "whether") courses for the future of the organization. The author relied extensively on the "History of the…

6th Annual National Small Business Conference

DTIC Science & Technology

2009-06-03

Extension Partnership – MIT Lean Advancement Initiative – Customers • Lean Tools – Value Stream Mapping – Kaizen Events Center for Management...Blue denotes kaizen events Most suppliers did not have in-house lean capability therefore the OEM and customer facilitated the events 36 Center for...Management & Economic Research 37 Kaizen Events • Kaizen is the process of: – Identifying & eliminating waste – as quickly as possible – at the

Building dialogue on complex conservation issues in a conference setting.

PubMed

Rock, Jenny; Sparrow, Andrew; Wass, Rob; Moller, Henrik

2014-10-01

Dialogue about complex science and society issues is important for contemporary conservation agendas. Conferences provide an appropriate space for such dialogue, but despite its recognized worth, best practices for facilitating active dialogue are still being explored. Face-to-face (FTF) and computer-mediated communication (CMC) are two approaches to facilitating dialogue that have different strengths. We assessed the use of these approaches to create dialogue on cultural perspectives of conservation and biodiversity at a national ecology conference. In particular, we aimed to evaluate their potential to enhance dialogue through their integrated application. We used an interactive blog to generate CMC on participant-sourced issues and to prime subsequent discussion in an FTF conference workshop. The quantity and quality of both CMC and FTF discussion indicated that both approaches were effective in building dialogue. Prior to the conference the blog averaged 126 views per day, and 44 different authors contributed a total of 127 comments. Twenty-five participants subsequently participated in active FTF discussion during a 3-h workshop. Postconference surveys confirmed that CMC had developed participants' thinking and deepened FTF dialogue; 88% indicated specifically that CMC helped facilitate the FTF discussion. A further 83% of respondents concluded that preliminary blog discussion would be useful for facilitating dialogue at future conferences. © 2014 Society for Conservation Biology.

ANTLR Tree Grammar Generator and Extensions

NASA Technical Reports Server (NTRS)

Craymer, Loring

2005-01-01

A computer program implements two extensions of ANTLR (Another Tool for Language Recognition), which is a set of software tools for translating source codes between different computing languages. ANTLR supports predicated- LL(k) lexer and parser grammars, a notation for annotating parser grammars to direct tree construction, and predicated tree grammars. [ LL(k) signifies left-right, leftmost derivation with k tokens of look-ahead, referring to certain characteristics of a grammar.] One of the extensions is a syntax for tree transformations. The other extension is the generation of tree grammars from annotated parser or input tree grammars. These extensions can simplify the process of generating source-to-source language translators and they make possible an approach, called "polyphase parsing," to translation between computing languages. The typical approach to translator development is to identify high-level semantic constructs such as "expressions," "declarations," and "definitions" as fundamental building blocks in the grammar specification used for language recognition. The polyphase approach is to lump ambiguous syntactic constructs during parsing and then disambiguate the alternatives in subsequent tree transformation passes. Polyphase parsing is believed to be useful for generating efficient recognizers for C++ and other languages that, like C++, have significant ambiguities.

Twitter use at the 2016 Conference on the Science of Dissemination and Implementation in Health: analyzing #DIScience16.

PubMed

Allen, Caitlin G; Andersen, Brittany; Chambers, David A; Groshek, Jacob; Roberts, Megan C

2018-02-20

Poor dissemination of research findings may hamper the reach and impact of scientific discoveries. One key emerging platform for research dissemination is social media, including Twitter. While Twitter and other social media are increasingly being used to disseminate research content presented during scientific conferences, few studies have investigated the extent to which these tools are used throughout conferences and how they are being used. The aim for this study was to better understand the use of Twitter during the 2016 Annual Conference on the Science of Dissemination and Implementation in Health (D&I conference). We performed an analysis of Twitter use before, during, and after the 2016 D&I conference, which took place from December 14 to 15. All tweets (posted between December 1 and 31) that included the conference-specific hashtag (#DIScience16) were assessed. We identified 2639 tweets using the data analytics platform NUVI. We used NUVI software to generate statistics about reach, influence, mentions, and origin of the tweets. Individual tweet content was also assessed using DiscoverText and coded for disease category, implementation outcomes discussed, category of tweet, and conference track. A total of 2639 tweets were analyzed; 89.1% of the tweets were posted during the conference. A total of 389 unique users participated on Twitter, representing 31 states and 22 locations outside of the USA. Most (56.8%) tweets were re-tweets and were used for scientific promotion (50.6%). Key conference speakers and implementation outcomes (de-implementation, adaptation, and fidelity) were commonly discussed. Our findings reveal that Twitter was used as a platform during the D&I conference, both to facilitate conference discussion and to promote scientific ideas. This work contributes to the existing data analytics and implementation science literature in two major ways: (1) by advancing knowledge of how social media is used during annual academic conferences and (2) by providing a deeper understanding of themes and emerging areas of interest in the dissemination and implementation sciences. Knowing specific topics of interest can help planners and scientists better understand the landscape of current and future implementation research and encourage new research dissemination strategies.

Voluntary Movement Frequencies in Submaximal One- and Two-Legged Knee Extension Exercise and Pedaling

PubMed Central

Stang, Julie; Wiig, Håvard; Hermansen, Marte; Hansen, Ernst Albin

2016-01-01

Understanding of behavior and control of human voluntary rhythmic stereotyped leg movements is useful in work to improve performance, function, and rehabilitation of exercising, healthy, and injured humans. The present study aimed at adding to the existing understanding within this field. To pursue the aim, correlations between freely chosen movement frequencies in relatively simple, single-joint, one- and two-legged knee extension exercise were investigated. The same was done for more complex, multiple-joint, one- and two-legged pedaling. These particular activities were chosen because they could be considered related to some extent, as they shared a key aspect of knee extension, and because they at the same time were different. The activities were performed at submaximal intensities, by healthy individuals (n = 16, thereof eight women; 23.4 ± 2.7 years; 1.70 ± 0.11 m; 68.6 ± 11.2 kg). High and fair correlations (R-values of 0.99 and 0.75) occurred between frequencies generated with the dominant leg and the nondominant leg during knee extension exercise and pedaling, respectively. Fair to high correlations (R-values between 0.71 and 0.95) occurred between frequencies performed with each of the two legs in an activity, and the two-legged frequency performed in the same type of activity. In general, the correlations were higher for knee extension exercise than for pedaling. Correlations between knee extension and pedaling frequencies were of modest occurrence. The correlations between movement frequencies generated separately by each of the legs might be interpreted to support the following working hypothesis, which was based on existing literature. It is likely that involved central pattern generators (CPGs) of the two legs share a common frequency generator or that separate frequency generators of each leg are attuned via interneuronal connections. Further, activity type appeared to be relevant. Thus, the apparent common rhythmogenesis for the two legs appeared to be stronger for the relatively simple single-joint activity of knee extension exercise as compared to the more complex multi-joint activity of pedaling. Finally, it appeared that the shared aspect of knee extension in the related types of activities of knee extension exercise and pedaling was insufficient to cause obvious correlations between generated movement frequencies in the two types of activities. PMID:26973486

EDITORIAL: Photonica 2011: 3rd International School and Conference on Photonics Photonica 2011: 3rd International School and Conference on Photonics

NASA Astrophysics Data System (ADS)

Petrović, Jovana; Stepić, Milutin; Hadžievski, Ljupčo

2012-04-01

Photonics is a rapidly growing discipline of physics that investigates properties of light and its interaction with matter and develops devices based on these properties. Due to both the fundamental and applied nature of photonics research, it pervades many branches of modern technology: quantum mechanics, material science, electronics, telecommunications, biology, medicine, material processing, etc. The borders between these subjects are being erased, generating new research areas such as silicon photonics, biophotonics and quantum photonics. Diverse branches of photonics are united in a common effort to further miniaturize photonic devices, integrate them with existing technologies and develop new technologies. The International School and Conference on Photonics—Photonica—is a biennial forum for the education of young scientists, exchanging new knowledge and ideas, and fostering collaboration between scientists working in photonic science and technology. Conference topics cover a broad range of research activities in optical materials, metamaterials and plasmonics, nonlinear optics, lasers, laser spectroscopy, biophotonics, optoelectronics, optocommunications, photonic crystals, holography, quantum optics and related topics in atomic physics. The aim of the organizers is to provide a platform for discussing new developments, concepts and future trends of various disciplines of photonics by bringing together researchers from academia, government and industrial laboratories. The educational element of Photonica—a series of tutorials and keynote talks—enables students and young researchers to better understand the fundamentals and their use on a route to applications, and informs both young and experienced scientists of new directions of research. The introductory lectures that are directly related to the state-of-the-art are followed by presentations and discussions on recent results during oral and vibrant poster presentations. This Topical Issue is dedicated to Photonica 2011 held on 29 August-2 September 2011 in Belgrade, Serbia. The conference was attended by 144 participants from 27 countries who gave 132 oral and poster presentations and 24 lectures. The accompanying papers were peer reviewed and 82 were selected for publication. We take this opportunity to gratefully acknowledge the contribution of the reviewers to the quality of this issue. The papers are grouped in accordance with the conference topics, each section opening with an invited paper. The issue begins with papers dedicated to ultra-cold atomic systems that display coherent behaviour analogous to that of light. These well-controlled atomic systems are indispensible workhorses for experiments in quantum optics, which is the topic of the next section. Holography as a concept, measurement tool and technique for fabrication of periodic photonic structures is placed accordingly between fundamental and applied photonics. It is followed by reports on various photonic devices, their modelling and nonlinear phenomena. The progress in constructing these devices largely depends on artificial (composites, metamaterials) and natural optical materials and their processing. This Topical Issue is an original snapshot of the current research in photonics and by no means an extensive survey of the field. While the making of the former has been a challenging task, the compilation of the latter would be indomitable due to the rapid advances in and diversification of photonics research. In accordance with the aims of the conference itself, we hope that the results reported in this Topical Issue of Physica Scripta will serve to inform and to spark the imagination of scientists and engineers exploring or using the principles and products of photonics.

Where are they now? - A case study of the impact of international travel support for early career Arctic researchers

NASA Astrophysics Data System (ADS)

Majaneva, Sanna; Hamon, Gwénaëlle; Fugmann, Gerlis; Lisowska, Maja; Baeseman, Jenny

2016-09-01

Supporting and training the next generation of researchers is crucial to continuous knowledge and leadership in Arctic research. An increasing number of Arctic organizations have developed initiatives to provide travel support for Early Career Researchers (ECRs) to participate in workshops, conferences and meetings and to network with internationally renowned scientific leaders. However, there has been little evaluation of the effectiveness of these initiatives. As a contribution to the 3rd International Conference on Arctic Research Planning, a study was conducted to analyze the career paths of ECRs who received travel funding from the International Arctic Science Committee between the start of the International Polar Year (2007-2008) and 2013. Two surveys were used: one sent to ECRs who received IASC travel support and one as a specific event study to those unsuccessfully applied for IASC travel support to the IPY 2010 Conference. The results of the surveys indicate that travel support was beneficial to both the research and careers of the respondents, especially if the ECR was engaged with a task or responsibility at the event. Survey responses also included suggestions on how funds could be better used to support the next generation of Arctic researchers.

Childbearing Differences among Three Generations of U.S. Women

MedlinePlus

... on Vital and Health Statistics Annual Reports Health Survey Research Methods Conference Reports from the National Medical Care Utilization and Expenditure Survey Clearinghouse on Health Indexes Statistical Notes for Health ...

Boat, wake, and wave real-time simulation

NASA Astrophysics Data System (ADS)

Świerkowski, Leszek; Gouthas, Efthimios; Christie, Chad L.; Williams, Owen M.

2009-05-01

We describe the extension of our real-time scene generation software VIRSuite to include the dynamic simulation of small boats and their wakes within an ocean environment. Extensive use has been made of the programmabilty available in the current generation of GPUs. We have demonstrated that real-time simulation is feasible, even including such complexities as dynamical calculation of the boat motion, wake generation and calculation of an FFTgenerated sea state.

Weight management by phone conference call: A comparison with a traditional face-to-face clinic. Rationale and design for a randomized equivalence trial

PubMed Central

Lambourne, Kate; Washburn, Richard A.; Gibson, Cheryl; Sullivan, Debra K.; Goetz, Jeannine; Lee, Robert; Smith, Bryan K.; Mayo, Matthew S.; Donnelly, Joseph E.

2012-01-01

State-of-the-art treatment for weight management consists of a behavioral intervention to facilitate decreased energy intake and increased physical activity. These interventions are typically delivered face-to-face (FTF) by a health educator to a small group of participants. There are numerous barriers to participation in FTF clinics including availability, scheduling, the expense and time required to travel to the clinic site, and possible need for dependent care. Weight management clinics delivered by conference call have the potential to diminish or eliminate these barriers. The conference call approach may also reduce burden on providers, who could conduct clinic groups from almost any location without the expenses associated with maintaining FTF clinic space. A randomized trial will be conducted in 395 overweight/obese adults (BMI 25–39.9 kg/m2) to determine if weight loss (6 months) and weight maintenance (12 months) are equivalent between weight management interventions utilizing behavioral strategies and pre-packaged meals delivered by either a conference call or the traditional FTF approach. The primary outcome, body weight, will be assessed at baseline, 6, 12 and 18 months. Secondary outcomes including waist circumference, energy and macronutrient intake, and physical activity and will be assessed on the same schedule. In addition, a cost analysis and extensive process evaluation will be completed. PMID:22664647

Weight management by phone conference call: a comparison with a traditional face-to-face clinic. Rationale and design for a randomized equivalence trial.

PubMed

Lambourne, Kate; Washburn, Richard A; Gibson, Cheryl; Sullivan, Debra K; Goetz, Jeannine; Lee, Robert; Smith, Bryan K; Mayo, Matthew S; Donnelly, Joseph E

2012-09-01

State-of-the-art treatment for weight management consists of a behavioral intervention to facilitate decreased energy intake and increased physical activity. These interventions are typically delivered face-to-face (FTF) by a health educator to a small group of participants. There are numerous barriers to participation in FTF clinics including availability, scheduling, the expense and time required to travel to the clinic site, and possible need for dependent care. Weight management clinics delivered by conference call have the potential to diminish or eliminate these barriers. The conference call approach may also reduce burden on providers, who could conduct clinic groups from almost any location without the expenses associated with maintaining FTF clinic space. A randomized trial will be conducted in 395 overweight/obese adults (BMI 25-39.9 kg/m(2)) to determine if weight loss (6 months) and weight maintenance (12 months) are equivalent between weight management interventions utilizing behavioral strategies and pre-packaged meals delivered by either a conference call or the traditional FTF approach. The primary outcome, body weight, will be assessed at baseline, 6, 12 and 18 months. Secondary outcomes including waist circumference, energy and macronutrient intake, and physical activity and will be assessed on the same schedule. In addition, a cost analysis and extensive process evaluation will be completed. Copyright © 2012 Elsevier Inc. All rights reserved.

78 FR 26662 - Entergy Nuclear Operations, Inc., Indian Point Nuclear Generating Unit No. 3 Extension of Public...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-07

... NUCLEAR REGULATORY COMMISSION [Docket Nos. 50-286; NRC-2013-0063] Entergy Nuclear Operations, Inc., Indian Point Nuclear Generating Unit No. 3 Extension of Public Comment Period AGENCY: Nuclear Regulatory... FURTHER INFORMATION CONTACT: Douglas V. Pickett, Senior Project Manager, Office of Nuclear Reactor...

NNSA Administrator Addresses the Next Generation of Nuclear Security Professionals: Part 2

ScienceCinema

Thomas D'Agostino

2017-12-09

Administrator Thomas DAgostino of the National Nuclear Security Administration addressed the next generation of nuclear security professionals during the opening session of todays 2009 Department of Energy (DOE) Computational Science Graduate Fellowship Annual Conference. Administrator DAgostino discussed NNSAs role in implementing President Obamas nuclear security agenda and encouraged the computing science fellows to consider careers in nuclear security.

NNSA Administrator Addresses the Next Generation of Nuclear Security Professionals: Part 1

ScienceCinema

Thomas D'Agostino

2017-12-09

Administrator Thomas DAgostino of the National Nuclear Security Administration addressed the next generation of nuclear security professionals during the opening session of todays 2009 Department of Energy (DOE) Computational Science Graduate Fellowship Annual Conference. Administrator DAgostino discussed NNSAs role in implementing President Obamas nuclear security agenda and encouraged the computing science fellows to consider careers in nuclear security.

Use of Long-Term E. Coli Cultures: To Study Generation of Genetic Diversity & Teach General Microbiology Laboratory Skills

ERIC Educational Resources Information Center

Petrie, Angela; Finkel, Steven E.; Erbe, Jarrod

2005-01-01

A novel method of studying the generation of genetic diversity in an undergraduate microbiology laboratory is described. The basis of this approach is the accumulation of mutations that confer a competitive advantage, or growth advantage in stationary phase (GASP) phenotype, to E. coli grown in stationary phase for extended periods of time.

Development of the Next Generation Air Quality Modeling System (20th Joint Conference on the Applications of Air Pollution Meteorology with the A&WMA)

EPA Science Inventory

A next generation air quality modeling system is being developed at the U.S. EPA to enable modeling of air quality from global to regional to (eventually) local scales. We envision that the system will have three configurations: 1. Global meteorology with seamless mesh refinemen...

Next-generation sequencing reveals a Novel NSCLC ALK F1174V mutation and confirms ALK G1202R mutation confers high-level resistance to alectinib (CH5424802/RO5424802) in ALK-rearranged NSCLC patients who progressed on crizotinib.

PubMed

Ignatius Ou, Sai-Hong; Azada, Michele; Hsiang, David J; Herman, June M; Kain, Tatiana S; Siwak-Tapp, Christina; Casey, Cameron; He, Jie; Ali, Siraj M; Klempner, Samuel J; Miller, Vincent A

2014-04-01

Acquired secondary mutations in the anaplastic lymphoma kinase (ALK) gene have been identified in ALK-rearranged (ALK+) non-small-cell lung cancer (NSCLC) patients who developed disease progression while on crizotinib treatment. Here, we identified a novel secondary acquired NSCLC ALK F1174V mutation by comprehensive next-generation sequencing in one ALK+ NSCLC patient who progressed on crizotinib after a prolonged partial response to crizotinib. In a second case, we identified a secondary acquired ALK G1202R, which also confers resistance to alectinib (CH5424802/RO5424802), a second-generation ALK inhibitor that can inhibit ALK gatekeeper L1196M mutation in vitro. ALK G1202R is located at the solvent front of the ALK kinase domain and exhibits a high level of resistance to all other ALK inhibitors currently in clinical development in vitro. Comprehensive genomic profiling of resistant tumor is increasingly important in tailoring treatment decisions after disease progression on crizotinib in ALK+ NSCLC given the promise of second-generation ALK inhibitors and other therapeutic strategies.

Space Electrochemical Research and Technology. Abstracts

NASA Technical Reports Server (NTRS)

1995-01-01

This document contains abstracts of the proceedings of NASA's fifth Space Electrochemical Research and Technology (SERT) Conference, held at the NASA Lewis Research Center on May 1-3, 1995. The objective of the conference was to assess the present status and general thrust of research and development in those areas of electrochemical technology required to enable NASA missions into the next century. The conference provided a forum for the exchange of ideas and opinions of those actively involved in the field, in order to define new opportunities for the application of electrochemical processes in future NASA missions. Papers were presented in three technical areas: (1) the electrochemical interface, (2) the next generation in aerospace batteries and fuel cells, and (3) electrochemistry for non-energy storage applications. This document contains the abstracts of the papers presented.

Progress report on new antiepileptic drugs: A summary of the Twelfth Eilat Conference (EILAT XII).

PubMed

Bialer, Meir; Johannessen, Svein I; Levy, René H; Perucca, Emilio; Tomson, Torbjörn; White, H Steve

2015-03-01

The Twelfth Eilat Conference on New Antiepileptic Drugs (AEDs) - EILAT XII, took place in Madrid, Spain from August 31st to September 3rd 2014. About 130 basic scientists, clinical pharmacologists and neurologists from 22 countries attended the conference, whose main themes included "Conquering pharmacoresistant epilepsy", "Innovative emergency treatments", "Progress report on second-generation treatment" and "New methods and formulations". Consistent with previous formats of this conference, a large part of the program was devoted to a review of AEDs in development, as well as updates on AEDs introduced since 2004. Like the EILAT X and EILAT XI reports, the current article focuses on the preclinical and clinical pharmacology of AEDs that are currently in development. These include adenosine-releasing silk, allopregnanolone (SAGE-547), AMP-X-0079, brivaracetam, bumetanide, cannabidiol, cannabidivarin, 2-deoxy-glucose, everolimus, ganaxolone, huperzine A, imepitoin, minocycline, NAX 801-2, pitolisant, PRX 0023, SAGE-217, valnoctamide and its homologue sec-butyl-propylacetamide (SPD), and VLB-01. Since the previous Eilat conference, perampanel has been introduced into the market and twelve novel potential epilepsy treatments are presented for the first time. Copyright © 2015 Elsevier B.V. All rights reserved.

The secretary's Conference for Youth on Drinking and Driving: special report.

PubMed Central

Callen, K

1983-01-01

Part of a Department of Health and Human Services initiative against teenage alcohol abuse, a national Conference for Youth on Drinking and Driving--held March 26-28, 1983 in Chevy Chase, Md. --brought together more than 300 high school student delegates and school superintendents from every State and Territory. The conference spotlighted successful programs that students around the country have undertaken to promote sober driving--programs that incorporate these key principles: (a) they rely almost solely on peer leadership "by students for students"; (b) they employ a "holistic" approach to health promotion, emphasizing self-esteem and alternatives to alcohol and drug abuse; and (c) they use the resources of the whole community. Working with student leaders of these model programs, conference delegates devised ways to launch similar programs in their own schools and communities and to enlist help from parents, teachers, lawmakers, the media, and business and civic groups. The Department of Health and Human Services plans to hold similar conferences annually, to mobilize future generations of students against drunk driving. Images p337-a p337-b p338-a p340-a p342-a PMID:6137022

Proceedings of the 4th Conference on Aerospace Materials, Processes, and Environmental Technology

NASA Technical Reports Server (NTRS)

Griffin, D. E. (Editor); Stanley, D. C. (Editor)

2001-01-01

The next millennium challenges us to produce innovative materials, processes, manufacturing, and environmental technologies that meet low-cost aerospace transportation needs while maintaining US leadership. The pursuit of advanced aerospace materials, manufacturing processes, and environmental technologies supports the development of safer, operational, next-generation, reusable, and expendable aeronautical and space vehicle systems. The Aerospace Materials, Processes, and Environmental Technology Conference (AMPET) provided a forum for manufacturing, environmental, materials, and processes engineers, scientists, and managers to describe, review, and critically assess advances in these key technology areas.

Noise control in aeroacoustics; Proceedings of the 1993 National Conference on Noise Control Engineering, NOISE-CON 93, Williamsburg, VA, May 2-5, 1993

NASA Technical Reports Server (NTRS)

Hubbard, Harvey H. (Editor)

1993-01-01

In the conference over 100 papers were presented in eight sessions: (1) Emission: Noise Sources; (2) Physical Phenomena; (3) Noise ControlElements; (4) Vibration and Shock: Generation, Transmission, Isolation, and Reduction; (5) Immission: Physical Aspects of Environmental Noise; (6) Immission: Effects of Noise; (7) Analysis; and (8) Requirements. In addition, the distinguished lecture series included presentations on the High Speed Civil Transport and on research from the United Kingdom on aircraft noise effects.

The International Conference on Intelligent Biology and Medicine (ICIBM) 2016: from big data to big analytical tools.

PubMed

Liu, Zhandong; Zheng, W Jim; Allen, Genevera I; Liu, Yin; Ruan, Jianhua; Zhao, Zhongming

2017-10-03

The 2016 International Conference on Intelligent Biology and Medicine (ICIBM 2016) was held on December 8-10, 2016 in Houston, Texas, USA. ICIBM included eight scientific sessions, four tutorials, one poster session, four highlighted talks and four keynotes that covered topics on 3D genomics structural analysis, next generation sequencing (NGS) analysis, computational drug discovery, medical informatics, cancer genomics, and systems biology. Here, we present a summary of the nine research articles selected from ICIBM 2016 program for publishing in BMC Bioinformatics.

Brainhack: a collaborative workshop for the open neuroscience community.

PubMed

Cameron Craddock, R; S Margulies, Daniel; Bellec, Pierre; Nolan Nichols, B; Alcauter, Sarael; A Barrios, Fernando; Burnod, Yves; J Cannistraci, Christopher; Cohen-Adad, Julien; De Leener, Benjamin; Dery, Sebastien; Downar, Jonathan; Dunlop, Katharine; R Franco, Alexandre; Seligman Froehlich, Caroline; J Gerber, Andrew; S Ghosh, Satrajit; J Grabowski, Thomas; Hill, Sean; Sólon Heinsfeld, Anibal; Matthew Hutchison, R; Kundu, Prantik; R Laird, Angela; Liew, Sook-Lei; J Lurie, Daniel; G McLaren, Donald; Meneguzzi, Felipe; Mennes, Maarten; Mesmoudi, Salma; O'Connor, David; H Pasaye, Erick; Peltier, Scott; Poline, Jean-Baptiste; Prasad, Gautam; Fraga Pereira, Ramon; Quirion, Pierre-Olivier; Rokem, Ariel; S Saad, Ziad; Shi, Yonggang; C Strother, Stephen; Toro, Roberto; Q Uddin, Lucina; D Van Horn, John; W Van Meter, John; C Welsh, Robert; Xu, Ting

2016-01-01

Brainhack events offer a novel workshop format with participant-generated content that caters to the rapidly growing open neuroscience community. Including components from hackathons and unconferences, as well as parallel educational sessions, Brainhack fosters novel collaborations around the interests of its attendees. Here we provide an overview of its structure, past events, and example projects. Additionally, we outline current innovations such as regional events and post-conference publications. Through introducing Brainhack to the wider neuroscience community, we hope to provide a unique conference format that promotes the features of collaborative, open science.

Formalizing Space Shuttle Software Requirements

NASA Technical Reports Server (NTRS)

Crow, Judith; DiVito, Ben L.

1996-01-01

This paper describes two case studies in which requirements for new flight-software subsystems on NASA's Space Shuttle were analyzed, one using standard formal specification techniques, the other using state exploration. These applications serve to illustrate three main theses: (1) formal methods can complement conventional requirements analysis processes effectively, (2) formal methods confer benefits regardless of how extensively they are adopted and applied, and (3) formal methods are most effective when they are judiciously tailored to the application.

Guidelines for the Collection, Maintenance & Dissemination of Pupil Records. Report of a Conference on the Ethical & Legal Aspects of School Record Keeping. (Sterling Forest, New York, May 25-28, 1969).

ERIC Educational Resources Information Center

Russell Sage Foundation, New York, NY.

Modern technology has given us the ability to record, store, retrieve, and disseminate large volumes of data. Though technically efficient, such a procedure can be misused and thus constitute an invasion of privacy. Most school systems maintain extensive student records, but few have systematic policies regarding dissemination of such information.…

Generation of three-dimensional body-fitted grids by solving hyperbolic partial differential equations

NASA Technical Reports Server (NTRS)

Steger, Joseph L.

1989-01-01

Hyperbolic grid generation procedures are described which have been used in external flow simulations about complex configurations. For many practical applications a single well-ordered (i.e., structured) grid can be used to mesh an entire configuration, in other problems, composite or unstructured grid procedures are needed. Although the hyperbolic partial differential equation grid generation procedure has mainly been utilized to generate structured grids, an extension of the procedure to semiunstructured grids is briefly described. Extensions of the methodology are also described using two-dimensional equations.

Generation of three-dimensional body-fitted grids by solving hyperbolic and parabolic partial differential equations

NASA Technical Reports Server (NTRS)

Steger, Joseph L.

1989-01-01

Hyperbolic grid generation procedures are described which have been used in external flow simulations about complex configurations. For many practical applications a single well-ordered (i.e., structured) grid can be used to mesh an entire configuration, in other problems, composite or unstructured grid procedures are needed. Although the hyperbolic partial differential equation grid generation procedure has mainly been utilized to generate structured grids, extension of the procedure to semiunstructured grids is briefly described. Extensions of the methodology are also described using two-dimensional equations.

Multiphase boudinage: a case study of amphibolites in marble in the Naxos migmatite core

NASA Astrophysics Data System (ADS)

Virgo, Simon; von Hagke, Christoph; Urai, Janos L.

2018-02-01

In multiply deformed terrains multiphase boudinage is common, but identification and analysis of these is difficult. Here we present an analysis of multiphase boudinage and fold structures in deformed amphibolite layers in marble from the migmatitic centre of the Naxos metamorphic core complex. Overprinting between multiple boudinage generations is shown in exceptional 3-D outcrop. We identify five generations of boudinage, reflecting the transition from high-strain high-temperature ductile deformation to medium- to low-strain brittle boudins formed during cooling and exhumation. All boudin generations indicate E-W horizontal shortening and variable direction of bedding parallel extension, evolving from subvertical extension in the earliest boudins to subhorizontal N-S extension during exhumation. Two phases of E-W shortening can be inferred, the first associated with lower crustal synmigmatic convergent flow and the second associated with exhumation and N-S extension, possibly related to movement of the North Anatolian Fault.

Postmortem Brain: An Underutilized Substrate for Studying Severe Mental Illness

PubMed Central

McCullumsmith, Robert E; Hammond, John H; Shan, Dan; Meador-Woodruff, James H

2014-01-01

We propose that postmortem tissue is an underutilized substrate that may be used to translate genetic and/or preclinical studies, particularly for neuropsychiatric illnesses with complex etiologies. Postmortem brain tissues from subjects with schizophrenia have been extensively studied, and thus serve as a useful vehicle for illustrating the challenges associated with this biological substrate. Schizophrenia is likely caused by a combination of genetic risk and environmental factors that combine to create a disease phenotype that is typically not apparent until late adolescence. The complexity of this illness creates challenges for hypothesis testing aimed at understanding the pathophysiology of the illness, as postmortem brain tissues collected from individuals with schizophrenia reflect neuroplastic changes from a lifetime of severe mental illness, as well as treatment with antipsychotic medications. While there are significant challenges with studying postmortem brain, such as the postmortem interval, it confers a translational element that is difficult to recapitulate in animal models. On the other hand, data derived from animal models typically provide specific mechanistic and behavioral measures that cannot be generated using human subjects. Convergence of these two approaches has led to important insights for understanding molecular deficits and their causes in this illness. In this review, we discuss the problem of schizophrenia, review the common challenges related to postmortem studies, discuss the application of biochemical approaches to this substrate, and present examples of postmortem schizophrenia studies that illustrate the role of the postmortem approach for generating important new leads for understanding the pathophysiology of severe mental illness. PMID:24091486

Older road user research plan

DOT National Transportation Integrated Search

2001-08-01

In 1999, the Transportation Research Board convened a meeting to discuss older road user issues. Many research and implementation ideas were generated at that conference, though not all of them fell within the National Highway Traffic Safety Administ...

The Role of Internships in Raising Undergraduates' Awareness and Perception of Extension

ERIC Educational Resources Information Center

Grotta, Amy; McGrath, Daniel

2013-01-01

Extension does not often reach out to undergraduates at their home institutions. Doing so might help Extension reach new audiences; leverage scarce resources; provide meaningful, community-based work experience; and perhaps recruit another generation of Extension professionals. We surveyed students who had completed internships with Extension…

Adding Test Generation to the Teaching Machine

ERIC Educational Resources Information Center

Bruce-Lockhart, Michael; Norvell, Theodore; Crescenzi, Pierluigi

2009-01-01

We propose an extension of the Teaching Machine project, called Quiz Generator, that allows instructors to produce assessment quizzes in the field of algorithm and data structures quite easily. This extension makes use of visualization techniques and is based on new features of the Teaching Machine that allow third-party visualizers to be added as…

The Astrobiology Graduate Conference - A Unique Early Career Opportunity

NASA Astrophysics Data System (ADS)

Knowles, E. J.; Domagal-Goldman, S. D.; Anderson, R.; Som, S. M.

2011-12-01

The Astrobiology Graduate Conference (AbGradCon) is an extremely successful annual meeting of early career researchers and educators involved and interested in the field of astrobiology. The conference has been held eight times in various locations, each time organized by a different group of students. The primary objective of AbGradCon is to stimulate the future of astrobiology research by bringing together graduate students and early post-doctoral fellows in order to create and strengthen interdisciplinary and international networks of early-career astrobiologists who will lead such research in the years to come. The conference is unique in that it is a student-led meeting, from the organization to the presentations. AbGradCon strives to remove the "pressures" of typical scientific meetings by providing a relaxed atmosphere in which presentations and round-table discussions are fostered along with numerous social activities. The success of previous AbGradCons can be attributed to the sheer enthusiasm of the participants for astrobiology, and to the spirit and format of the conference, which is outlined in a charter written by past conference organizers and participants. Because it is organized and attended by only graduate students and early career astrobiologists, AbGradCon is an ideal venue for the next generation of early career astrobiologists to form bonds, share ideas, and discuss the issues that will shape the future of the field.

The Use of a Dexamethasone-inducible System to Synchronize Xa21 Expression to Study Rice Immunity.

PubMed

Caddell, Daniel F; Wei, Tong; Park, Chang-Jin; Ronald, Pamela C

2015-05-05

Inducible gene expression systems offer researchers the opportunity to synchronize target gene expression at particular developmental stages and in particular tissues. The glucocorticoid receptor (GR), a vertebrate steroid receptor, has been well adopted for this purpose in plants. To generate steroid-inducible plants, a construct of GAL4-binding domain-VP16 activation domain-GR fusion (GVG) with the target gene under the control of upstream activation sequence (UAS) has been developed and extensively used in plant research. Immune receptors perceive conserved molecular patterns secreted by pathogens and initiate robust immune responses. The rice immune receptor, XA21 , recognizes a molecular pattern highly conserved in all sequenced genomes of Xanthomonas , and confers robust resistance to X. oryzae pv. oryzae ( Xoo ). However, identifying genes downstream of XA21 has been hindered because of the restrained lesion and thus limited defense response region in the plants expressing Xa21 . Inducible expression allows for a synchronized immune response across a large amount of rice tissue, well suited for studying XA21-mediated immunity by genome-wide approaches such as transcriptomics and proteomics. In this protocol, we describe the use of this GVG system to synchronize Xa21 expression.

Peptide selection and antibody generation for the prospective immunorecognition of Cry1Ab16 protein of transgenic maize.

PubMed

Costa, Joana; Marani, Mariela M; Grazina, Liliana; Villa, Caterina; Meira, Liliana; Oliveira, M Beatriz P P; Leite, José R S A; Mafra, Isabel

2017-09-15

The introduction of genes isolated from different Bacillus thuringiensis strains to express Cry-type toxins in transgenic crops is a common strategy to confer insect resistance traits. This work intended to extensively in silico analyse Cry1A(b)16 protein for the identification of peptide markers for the biorecognition of transgenic crops. By combining two different strategies based on several bioinformatic tools for linear epitope prediction, a set of seven peptides was successfully selected as potential Cry1A(b)16 immunogens. For the prediction of conformational epitopes, Cry1A(b)16 models were built on the basis of three independent templates of homologue proteins of Cry1A(a) and Cry1A(c) using an integrated approach. PcH_736-746 and PcH_876-886 peptides were selected as the best candidates, being synthesised and used for the production of polyclonal antibodies. To the best of our knowledge, this is the first attempt of selecting and defining linear peptides as immunogenic markers of Cry1A(b)-type toxins in transgenic maize. Copyright © 2017 Elsevier Ltd. All rights reserved.

The Use of a Dexamethasone-inducible System to Synchronize Xa21 Expression to Study Rice Immunity

PubMed Central

Caddell, Daniel F.; Wei, Tong; Park, Chang-Jin; Ronald, Pamela C.

2016-01-01

Inducible gene expression systems offer researchers the opportunity to synchronize target gene expression at particular developmental stages and in particular tissues. The glucocorticoid receptor (GR), a vertebrate steroid receptor, has been well adopted for this purpose in plants. To generate steroid-inducible plants, a construct of GAL4-binding domain-VP16 activation domain-GR fusion (GVG) with the target gene under the control of upstream activation sequence (UAS) has been developed and extensively used in plant research. Immune receptors perceive conserved molecular patterns secreted by pathogens and initiate robust immune responses. The rice immune receptor, XA21, recognizes a molecular pattern highly conserved in all sequenced genomes of Xanthomonas, and confers robust resistance to X. oryzae pv. oryzae (Xoo). However, identifying genes downstream of XA21 has been hindered because of the restrained lesion and thus limited defense response region in the plants expressing Xa21. Inducible expression allows for a synchronized immune response across a large amount of rice tissue, well suited for studying XA21-mediated immunity by genome-wide approaches such as transcriptomics and proteomics. In this protocol, we describe the use of this GVG system to synchronize Xa21 expression. PMID:27525297

Reduced Pressure Cabin Testing of the Orion Atmosphere Revitalization Technology

NASA Technical Reports Server (NTRS)

Button, Amy; Sweterlitsch, Jeffrey

2011-01-01

An amine-based carbon dioxide (CO2) and water vapor sorbent in pressure-swing regenerable beds has been developed by Hamilton Sundstrand and baselined for the Atmosphere Revitalization System for moderate duration missions of the Orion Multipurpose Crew Vehicle. In previous years at this conference, reports were presented on extensive Johnson Space Center testing of this technology in a sea-level pressure environment with simulated and actual human metabolic loads in both open and closed-loop configurations. In 2011, the technology was tested in an open cabin-loop configuration at ambient and two sub-ambient pressures to compare the performance of the system to the results of previous tests at ambient pressure. The testing used a human metabolic simulator with a different type of water vapor generation than previously used, which added some unique challenges in the data analysis. This paper summarizes the results of: baseline and some matrix testing at all three cabin pressures, increased vacuum regeneration line pressure with a high metabolic load, a set of tests studying CO2 and water vapor co-adsorption effects relative to model-predicted performance, and validation tests of flight program computer model predictions with specific operating conditions.

Reduced Pressure Cabin Testing of the Orion Atmosphere Revitalization Technology

NASA Technical Reports Server (NTRS)

Button, Amy; Sweterlisch, Jeffery J.

2013-01-01

An amine-based carbon dioxide (CO2) and water vapor sorbent in pressure-swing regenerable beds has been developed by Hamilton Sundstrand and baselined for the Atmosphere Revitalization System for moderate duration missions of the Orion Multipurpose Crew Vehicle. In previous years at this conference, reports were presented on extensive Johnson Space Center testing of this technology in a sea-level pressure environment with simulated and actual human metabolic loads in both open and closed-loop configurations. In 2011, the technology was tested in an open cabin-loop configuration at ambient and two sub-ambient pressures to compare the performance of the system to the results of previous tests at ambient pressure. The testing used a human metabolic simulator with a different type of water vapor generation than previously used, which added some unique challenges in the data analysis. This paper summarizes the results of: baseline and some matrix testing at all three cabin pressures, increased vacuum regeneration line pressure with a high metabolic load, a set of tests studying CO2 and water vapor co-adsorption effects relative to model-predicted performance, and validation tests of flight program computer model predictions with specific operating conditions.

Reduced Pressure Cabin Testing of the Orion Atmosphere Revitalization Technology

NASA Technical Reports Server (NTRS)

Button, Amy B.; Sweterlitsch, Jeffrey J.

2013-01-01

An amine-based carbon dioxide (CO2) and water vapor sorbent in pressure-swing regenerable beds has been developed by United Technologies Corp. Aerospace Systems (UTAS, formerly Hamilton Sundstrand) and baselined for the Atmosphere Revitalization System for moderate duration missions of the Orion Multipurpose Crew Vehicle (MPCV). In previous years at this conference, reports were presented on extensive Johnson Space Center testing of this technology in a sea-level pressure environment with simulated and actual human metabolic loads in both open and closed-loop configurations. In 2011, the technology was tested in an open cabin-loop configuration at ambient and two sub-ambient pressures to compare the performance of the system to the results of previous tests at ambient pressure. The testing used a human metabolic simulator with a different type of water vapor generation than previously used, which added some unique challenges in the data analysis. This paper summarizes the results of: baseline and some matrix testing at all three cabin pressures, increased vacuum regeneration line pressure testing with a high metabolic load, a set of tests studying CO2 and water vapor co-adsorption effects relative to model-predicted performance, and validation tests of flight project computer model predictions with specific operating conditions.

Type II fish antifreeze protein accumulation in transgenic tobacco does not confer frost resistance.

PubMed

Kenward, K D; Brandle, J; McPherson, J; Davies, P L

1999-04-01

Type II fish antifreeze protein (AFP) is active in both freezing point depression and the inhibition of ice recrystallization. This extensively disulfide-bonded 14 kDa protein was targeted for accumulation in its pro- and mature forms in the cytosol and apoplast of transgenic tobacco plants. Type II AFP gene constructs under control of a duplicate cauliflower mosaic virus 35S promoter, both with and without a native plant transit peptide sequence, were introduced into tobacco by Agrobacterium tumefaciens-mediated transformation. AFP did not accumulate in the cytosol of transgenic plants, but active AFP was present as 2% the total protein present in the apoplast. Plant-produced AFP was the same size as mature Type II AFP isolated from fish, and was comparable to wild-type AFP in thermal hysteresis activity and its effect on ice crystal morphology. Field trials conducted in late summer on R1 generation transgenic plants showed similar AFP accumulation in plants under field conditions at levels suitable for large-scale production: but no difference in frost resistance was observed between transgenic and wild-type plants during the onset of early fall frosts.

20th International Conference for Students and Young Scientists: Modern Techniques and Technologies (MTT'2014)

NASA Astrophysics Data System (ADS)

2014-10-01

The active involvement of young researchers in scientific processes and the acquisition of scientific experience by gifted youth currently have a great value for the development of science. One of the research activities of National Research Tomsk Polytechnic University, aimed at the preparing and formation of the next generation of scientists, is the International Conference of Students and Young Scientists ''Modern Techniques and Technologies'', which was held in 2014 for the twentieth time. Great experience in the organization of scientific events has been acquired through years of carrying the conference. There are all the necessary resources for this: a team of organizers - employees of Tomsk Polytechnic University, premises provided with modern office equipment and equipment for demonstration, and leading scientists - professors of TPU, as well as the status of the university as a leading research university in Russia. This way the conference is able to attract world leading scientists for the collaboration. For the previous years the conference proved itself as a major scientific event at international level, which attracts more than 600 students and young scientists from Russia, CIS and other countries. The conference provides oral plenary and section reports. The conference is organized around lectures, where leading Russian and foreign scientists deliver plenary presentations to young audiences. An important indicator of this scientific event is the magnitude of the coverage of scientific fields: energy, heat and power, instrument making, engineering, systems and devices for medical purposes, electromechanics, material science, computer science and control in technical systems, nanotechnologies and nanomaterials, physical methods in science and technology, control and quality management, design and technology of artistic materials processing. The main issues considered by young researchers at the conference were related to the analysis of contemporary problems using new techniques and application of new technologies.

Acoustical case studies of three green buildings

NASA Astrophysics Data System (ADS)

Siebein, Gary; Lilkendey, Robert; Skorski, Stephen

2005-04-01

Case studies of 3 green buildings with LEED certifications that required extensive acoustical retrofit work to become satisfactory work environments for their intended user groups will be used to define areas where green building design concepts and acoustical design concepts require reconciliation. Case study 1 is an office and conference center for a city environmental education agency. Large open spaces intended to collect daylight through clerestory windows provided large, reverberant volumes with few acoustic finishes that rendered them unsuitable as open office space and a conference room/auditorium. Case Study 2 describes one of the first gold LEED buildings in the southeast whose primary design concepts were so narrowly focused on thermal and lighting issues that they often worked directly against basic acoustical requirements resulting in sound levels of NC 50-55 in classrooms and faculty offices, crosstalk between classrooms and poor room acoustics. Case study 3 is an environmental education and conference center with open public areas, very high ceilings, and all reflective surfaces made from wood and other environmentally friendly materials that result in excessive loudness when the building is used by the numbers of people which it was intended to serve.

The Relationship of College-Generational Status to the Academic Motivation and Persistence of African American Students at an Historically Black University

ERIC Educational Resources Information Center

Wiltsher, Cheree Y.

2016-01-01

The improvement of first generation college student persistence and graduation rates is an undertaking that benefits individuals, society, and the institutions whose mission it is to confer degrees. This goal is one that is best served by an acknowledgment of the causes of attrition as well as understanding the factors that strengthen and…

Sixth International Conference on Squeezed States and Uncertainty Relations

NASA Technical Reports Server (NTRS)

Han, D. (Editor); Kim, Y. S. (Editor); Solimento, S. (Editor)

2000-01-01

These proceedings contain contributions from about 200 participants to the 6th International Conference on Squeezed States and Uncertainty Relations (ICSSUR'99) held in Naples May 24-29, 1999, and organized jointly by the University of Naples "Federico II," the University of Maryland at College Park, and the Lebedev Institute, Moscow. This was the sixth of a series of very successful meetings started in 1990 at the College Park Campus of the University of Maryland. The other meetings in the series were held in Moscow (1992), Baltimore (1993), Taiyuan P.R.C. (1995) and Balatonfuered, Hungary (1997). The present one was held at the campus Monte Sant'Angelo of the University "Federico II" of Naples. The meeting sought to provide a forum for updating and reviewing a wide range of quantum optics disciplines, including device developments and applications, and related areas of quantum measurements and quantum noise. Over the years, the ICSSUR Conference evolved from a meeting on quantum measurement sector of quantum optics, to a wide range of quantum optics themes, including multifacet aspects of generation, measurement, and applications of nonclassical light (squeezed and Schrodinger cat radiation fields, etc.), and encompassing several related areas, ranging from quantum measurement to quantum noise. ICSSUR'99 brought together about 250 people active in the field of quantum optics, with special emphasis on nonclassical light sources and related areas. The Conference was organized in 8 Sections: Squeezed states and uncertainty relations; Harmonic oscillators and squeeze transformations; Methods of quantum interference and correlations; Quantum measurements; Generation and characterisation of non-classical light; Quantum noise; Quantum communication and information; and Quantum-like systems.

Investing in life saving vaccines to guarantee life of future generations in Africa.

PubMed

Mihigo, R M; Okeibunor, J C; O'Malley, H; Masresha, B; Mkanda, P; Zawaira, F

2016-11-21

The World Health Organization's Regional Offices for Africa and for the Eastern Mediterranean in conjunction with the African Union and the Government of Ethiopia hosted a ministerial conference on immunization in Africa from 24 to 25 February 2016 in Addis Ababa, Ethiopia under the theme "towards universal immunization coverage as a cornerstone for health and development in Africa". The conference brought together African leaders - including health and finance ministers, and parliamentarians thus creating a powerful platform for governments to demonstrate their commitment to advancing universal access to immunization on the continent in line with the Global Vaccine Action Plan. The event also brought together advocates, technical experts, policymakers, partner agencies, donors and journalists to examine how best to drive forward immunization across Africa, ensuring every child has access to the vaccines they need. Key points highlighted throughout conference were: universal access to immunization is at the forefront of enabling Africa to reach its full potential - by improving health, driving economic growth and empowering future generations; it is one of the most cost-effective solutions in global health, with clear benefits for health and development; and immunization brings economic benefits too, reducing health care costs and increasing productivity. At the close of the conference, 46 African countries signed a historic ministerial declaration on "Universal Access to Immunization as a Cornerstone for Health and Development in Africa" signaling fierce determination among African leaders to secure the health and prosperity of their societies through immunization. Copyright © 2016 World Health Organization Regional Office for Africa. Published by Elsevier Ltd.. All rights reserved.

Promises and pitfalls of Illumina sequencing for HIV resistance genotyping.

PubMed

Brumme, Chanson J; Poon, Art F Y

2017-07-15

Genetic sequencing ("genotyping") plays a critical role in the modern clinical management of HIV infection. This virus evolves rapidly within patients because of its error-prone reverse transcriptase and short generation time. Consequently, HIV variants with mutations that confer resistance to one or more antiretroviral drugs can emerge during sub-optimal treatment. There are now multiple HIV drug resistance interpretation algorithms that take the region of the HIV genome encoding the major drug targets as inputs; expert use of these algorithms can significantly improve to clinical outcomes in HIV treatment. Next-generation sequencing has the potential to revolutionize HIV resistance genotyping by lowering the threshold that rare but clinically significant HIV variants can be detected reproducibly, and by conferring improved cost-effectiveness in high-throughput scenarios. In this review, we discuss the relative merits and challenges of deploying the Illumina MiSeq instrument for clinical HIV genotyping. Copyright © 2016 Elsevier B.V. All rights reserved.

Galilei group with multiple central extension, vorticity, and entropy generation: Exotic fluid in 3 +1 dimensions

NASA Astrophysics Data System (ADS)

Das, Praloy; Ghosh, Subir

2017-12-01

A noncommutative extension of an ideal (Hamiltonian) fluid model in 3 +1 dimensions is proposed. The model enjoys several interesting features: it allows a multiparameter central extension in Galilean boost algebra (which is significant being contrary to the existing belief that a similar feature can appear only in 2 +1 -dimensions); noncommutativity generates vorticity in a canonically irrotational fluid; it induces a nonbarotropic pressure leading to a nonisentropic system. (Barotropic fluids are entropy preserving as the pressure depends only on the matter density.) Our fluid model is termed "exotic" since it has a close resemblance with the extensively studied planar (2 +1 dimensions) exotic models and exotic (noncommutative) field theories.

75 FR 5866 - Proposed Collection; Comment Request for Form 4768

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-04

...: Application for Extension of Time To File a Return and/or Pay U.S. Estate (and Generation-Skipping Transfer... 4768, Application for Extension of Time To File a Return and/or Pay U.S. Estate (and Generation-Skipping Transfer) Taxes. DATES: Written comments should be received on or before April 5, 2010 to be...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Babiuch, B.; Bilello, D. E.; Cowlin, S. C.

The 2008 Washington International Renewable Energy Conference (WIREC) was held in Washington, D.C., from March 4-6, 2008, and involved nearly 9,000 people from 125 countries. The event brought together worldwide leaders in renewable energy (RE) from governments, international organizations, nongovernmental organizations, and the private sector to discuss the role that renewables can play in alleviating poverty, growing economies, and passing on a healthy planet to future generations. The conference concluded with more than 140 governments, international organizations, and private-sector representatives pledging to advance the uptake of renewable energy. The U.S. government authorized the National Renewable Energy Laboratory (NREL) to estimatemore » the carbon dioxide (CO2) savings that would result from the pledges made at the 2008 conference. This report describes the methodology and assumptions used by NREL in quantifying the potential CO2 reductions derived from those pledges.« less

STS-114: Discovery Launch Readiness Press Conference

NASA Technical Reports Server (NTRS)

2005-01-01

Michael Griffin, NASA Administrator; Wayne Hale, Space Shuttle Deputy Program Manager; Mike Wetmore, Director of Shuttle Processing; and 1st Lieutenant Mindy Chavez, Launch Weather Officer-United States Air Force 45th Weather Squadron are in attendance for this STS-114 Discovery launch readiness press conference. The discussion begins with Wayne Hale bringing to the table a low level sensor device for everyone to view. He talks in detail about all of the extensive tests that were performed on these sensors and the completion of these ambient tests. Chavez presents her weather forecast for the launch day of July 26th 2005. Michael Griffin and Wayne Hale answer questions from the news media pertaining to the sensors and launch readiness. The video ends with footage of Pilot Jim Kelly and Commander Eileen Collins conducting test flights in a Shuttle Training Aircraft (STA) that simulates Space Shuttle landing.

Bioelectrical impedance methods in clinical research: a follow-up to the NIH Technology Assessment Conference.

PubMed

Ellis, K J; Bell, S J; Chertow, G M; Chumlea, W C; Knox, T A; Kotler, D P; Lukaski, H C; Schoeller, D A

1999-01-01

In 1994, the National Institutes of Health (NIH) convened a Technology Assessment Conference "to provide physicians with a responsible assessment of bioelectrical impedance analysis (BIA) technology for body composition measurement." In 1997, Serono Symposia USA, Inc., organized an invited panel of scientists and clinicians, with extensive research and clinical experience with BIA, to provide an update. Panel members presented reviews based on their own work and published studies for the intervening years. Updates were provided on the single and multifrequency BIA methods and models; continued clinical research experiences; efforts toward establishing population reference norms; and the feasibility of establishing guidelines for potential diagnostic use of BIA in a clinical setting. This report provides a summary of the panel's findings including a consensus on several technical and clinical issues related to the research use of BIA, and those areas that are still in need of additional study.

The eukaryote-specific N-terminal extension of ribosomal protein S31 contributes to the assembly and function of 40S ribosomal subunits

PubMed Central

Fernández-Pevida, Antonio; Martín-Villanueva, Sara; Murat, Guillaume; Lacombe, Thierry; Kressler, Dieter; de la Cruz, Jesús

2016-01-01

The archaea-/eukaryote-specific 40S-ribosomal-subunit protein S31 is expressed as an ubiquitin fusion protein in eukaryotes and consists of a conserved body and a eukaryote-specific N-terminal extension. In yeast, S31 is a practically essential protein, which is required for cytoplasmic 20S pre-rRNA maturation. Here, we have studied the role of the N-terminal extension of the yeast S31 protein. We show that deletion of this extension partially impairs cell growth and 40S subunit biogenesis and confers hypersensitivity to aminoglycoside antibiotics. Moreover, the extension harbours a nuclear localization signal that promotes active nuclear import of S31, which associates with pre-ribosomal particles in the nucleus. In the absence of the extension, truncated S31 inefficiently assembles into pre-40S particles and two subpopulations of mature small subunits, one lacking and another one containing truncated S31, can be identified. Plasmid-driven overexpression of truncated S31 partially suppresses the growth and ribosome biogenesis defects but, conversely, slightly enhances the hypersensitivity to aminoglycosides. Altogether, these results indicate that the N-terminal extension facilitates the assembly of S31 into pre-40S particles and contributes to the optimal translational activity of mature 40S subunits but has only a minor role in cytoplasmic cleavage of 20S pre-rRNA at site D. PMID:27422873

The eukaryote-specific N-terminal extension of ribosomal protein S31 contributes to the assembly and function of 40S ribosomal subunits.

PubMed

Fernández-Pevida, Antonio; Martín-Villanueva, Sara; Murat, Guillaume; Lacombe, Thierry; Kressler, Dieter; de la Cruz, Jesús

2016-09-19

The archaea-/eukaryote-specific 40S-ribosomal-subunit protein S31 is expressed as an ubiquitin fusion protein in eukaryotes and consists of a conserved body and a eukaryote-specific N-terminal extension. In yeast, S31 is a practically essential protein, which is required for cytoplasmic 20S pre-rRNA maturation. Here, we have studied the role of the N-terminal extension of the yeast S31 protein. We show that deletion of this extension partially impairs cell growth and 40S subunit biogenesis and confers hypersensitivity to aminoglycoside antibiotics. Moreover, the extension harbours a nuclear localization signal that promotes active nuclear import of S31, which associates with pre-ribosomal particles in the nucleus. In the absence of the extension, truncated S31 inefficiently assembles into pre-40S particles and two subpopulations of mature small subunits, one lacking and another one containing truncated S31, can be identified. Plasmid-driven overexpression of truncated S31 partially suppresses the growth and ribosome biogenesis defects but, conversely, slightly enhances the hypersensitivity to aminoglycosides. Altogether, these results indicate that the N-terminal extension facilitates the assembly of S31 into pre-40S particles and contributes to the optimal translational activity of mature 40S subunits but has only a minor role in cytoplasmic cleavage of 20S pre-rRNA at site D. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

2012 Gordon Research Conference, Mitochondria and Chloroplasts, July 29 - Aug 3 2012

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barkan, Alice

2012-08-03

The 2012 Gordon Research Conference on Mitochondria and Chloroplasts will assemble an international group of scientists investigating fundamental properties of these organelles, and their integration into broader physiological processes. The conference will emphasize the many commonalities between mitochondria and chloroplasts: their evolution from bacterial endosymbionts, their genomes and gene expression systems, their energy transducing membranes whose proteins derive from both nuclear and organellar genes, the challenge of maintaining organelle integrity in the presence of the reactive oxygen species that are generated during energy transduction, their incorporation into organismal signaling pathways, and more. The conference will bring together investigators working inmore » animal, plant, fungal and protozoan systems who specialize in cell biology, genetics, biochemistry, physiology, proteomics, genomics, and structural biology. As such, this conference will provide a unique forum that engenders cross-disciplinary discussions concerning the biogenesis, dynamics, and regulation of these key cellular structures. By fostering interactions among mammalian, fungal and plant organellar biologists, this conference also provides a conduit for the transmission of mechanistic insights obtained in model organisms to applications in medicine and agriculture. The 2012 conference will highlight areas that are moving rapidly and emerging themes. These include new insights into the ultrastructure and organization of the energy transducing membranes, the coupling of organellar gene expression with the assembly of photosynthetic and respiratory complexes, the regulatory networks that couple organelle biogenesis with developmental and physiological signals, the signaling events through which organellar physiology influences nuclear gene expression, and the roles of organelles in disease and development.« less

Contract W911NF-09-1-0488 (Rush University Medical Center)

DTIC Science & Technology

2012-11-23

algorithm. In Proceedings of the 1993 ACM/IEEE Conference on Supercomputing, pages 12�21, New York, 1993. ACM. [8] R. Yokota, T. Hamada, J. P. Bardhan , M...computing gravity anom- alies. Geophysical Journal International, 2011. to appear. [13] R. Yokota, T. Hamada, J. P. Bardhan , M. G. Knepley, and L. A. Barba...extension of the petfmm a fast multipole library. Presentation at WCCM 2010, Sydney Australia, 2010. [15] J. P. Bardhan . Interpreting the Coulomb

Proceedings of the 17th Conference on Toxicology Held in Dayton, Ohio on 3-5 November 1987

DTIC Science & Technology

1989-09-01

mixtures often consist of solvents. One group of solvents that has been extensively studied for its neurotoxic properties has been the ketones. However...for workers. The purpose of this 40 research was to study a combination exposure from the same chemical group , test for possible neurobehavioral...2) comparable workers not using PGDN, and (3) an unrelated group of sailors involved in weapons guidance. The study period was from 1966 through

Proposal to Develop Enhancements and Extensions of Formal Models for Risk Assessment In Software Projects

DTIC Science & Technology

2002-09-01

seconds per minute that the runtime environment was up and running. Defect Categories. The labels of the 5 defect categories. 78 Cosmetic Defects...The name that corresponds to QSM’s cosmetic defects. Cosmetic defects can be described as deferred, such as errors in format of displays or...2002. [Fent00] Fenton , N. E. and Neil, M. Software Metrics: Roadmap. Proceedings of the Conference on the Future of Software Engineering, 2000, pp

Study and optimization of negative polarity rod pinch diode as flash radiography source at 4.5 MV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Etchessahar, Bertrand; Bicrel, Beatrice; Cassany, Bruno

2012-09-15

The negative polarity rod pinch diode (NPRPD) is a potential millimeter spot size radiography source for high voltage generators (4 to 8 MV) [Cooperstein et al., 'Considerations of rod-pinch diode operation in negative polarity for radiography,' in Proceedings of the 14th IEEE Pulsed Power Conference, 2003, pp. 975-978]. The NPRPD consists of a small diameter (few mm) cylindrical anode extending from the front end of the vacuum cell through a thin annular cathode, held by a central conductor. The polarity has been inverted when compared to the original rod pinch diode [Cooperstein et al., 'Theoretical modeling and experimental characterization ofmore » a rod-pinch diode,' Phys. Plasmas 8(10), 4618-4636 (2001)] in order to take advantage from the maximal x-ray emission toward the anode holder at such a voltage [Swanekamp et al., 'Evaluation of self-magnetically pinched diodes up to 10 MV as high resolution flash X-ray sources,' IEEE Trans. Plasma Sci. 32(5), 2004-2016 (2004). We have studied this diode at 4.5 MV, driven by the ASTERIX generator [Raboisson et al., 'ASTERIX, a high intensity X-ray generator,' in Proceedings of the 7th IEEE Pulsed Power Conference, 1989, pp. 567-570.]. This generator, made up of a capacitor bank and a Blumlein line, was initially designed to test the behavior of electronic devices under irradiation. In our experiments, the vacuum diode has been modified in order to set up flash a radiographic diode [Etchessahar et al., 'Negative polarity rod pinch diode experiments on the ASTERIX generator,' in Conference Records-Abstracts, 37th IEEE International Conference on Plasma Science, 2010]. The experiments and numerical simulations presented here allowed the observation and analysis of various physical phenomena associated with the diode operation. Also, the influence of several experimental parameters, such as cathode and anode diameters, materials and surface states, was examined. In order to achieve the most comprehensive characterization of the diode, both optical and x-ray diagnostics were used, including high speed multi-image ICCD (intensified CCD) cameras, streak camera, dosimeters, spot size measurements, and pinhole cameras. A set of new results have been obtained through this study. The plasma emission from the anode and cathode surfaces and its expansion appear to be critical for the diode functioning. Also, for the first time, potential sources of diode instability were identified. Finally, an optimal and stable diode configuration was found with the following parameters: 52 rad at 1 m (in Al) and 2.2 mm spot size.« less

Nonuniformity of Temperatures in Microwave Steam Heating of Lobster Tail.

PubMed

Fleischman, Gregory J

2016-11-01

The biennial Conference for Food Protection provides a formal process for all interested parties to influence food safety guidance. At a recent conference, an issue was raised culminating in a formal request to the U.S. Food and Drug Administration to change its Food Code recommendation for safe cooking of seafood using microwave energy when steaming was also employed. The request was to treat microwave steam cooked seafood as a conventionally cooked raw animal product rather than a microwave cooked product, for which the safe cooking recommendation is more extensive owing to the complex temperature distributions in microwave heating. The request was motivated by a literature study that revealed a more uniform temperature distribution in microwave steam cooked whole lobster. In that study, single-point temperatures were recorded in various sections of the whole lobster, but only one temperature was recorded in the tail, although the large size of the tail could translate to multiple hot and cold points. The present study was conducted to examine lobster tail specifically, measuring temperatures at multiple points during microwave steam cooking. Large temperature differences, greater than 60°C at times, were found throughout the heating period. To compensate for such differences, the Food Code recommends a more extensive level of cooking when microwave energy, rather than conventional heat sources, is used. Therefore, a change in the Food Code regarding microwave steam heating cannot be recommended.

Twenty-second Fungal Genetics Conference - Asilomar, 2003

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jonathan D. Walton

The purpose of the Twenty Second Fungal Genetics Conference is to bring together scientists and students who are interested in genetic approaches to studying the biology of filamentous fungi. It is intended to stimulate thinking and discussion in an atmosphere that supports interactions between scientists at different levels and in different disciplines. Topics range from the basic to the applied. Filamentous fungi impact human affairs in many ways. In the environment they are the most important agents of decay and nutrient turnover. They are used extensively in the food industry for the production of food enzymes such as pectinase andmore » food additives such as citric acid. They are used in the production of fermented foods such as alcoholic drinks, bread, cheese, and soy sauce. More than a dozen species of mushrooms are used as foods directly. Many of our most important antibiotics, such as penicillin, cyclosporin, and lovastatin, come from fungi. Fungi also have many negative impacts on human health and economics. Fungi are serious pathogens in immuno-compromised patients. Fungi are the single largest group of plant pathogens and thus a serious limit on crop productivity throughout the world. Many fungi are allergenic, and mold contamination of residences and commercial buildings is now recognized as a serious public health threat. As decomposers, fungi cause extensive damage to just about all natural and synthetic materials.« less

Occurrence, genetic control and evolution of non-target-site based resistance to herbicides inhibiting acetolactate synthase (ALS) in the dicot weed Papaver rhoeas.

PubMed

Scarabel, Laura; Pernin, Fanny; Délye, Christophe

2015-09-01

Non-target-site resistance (NTSR) to herbicides is a major issue for the chemical control of weeds. Whilst predominant in grass weeds, NTSR remains largely uninvestigated in dicot weeds. We investigated the occurrence, inheritance and genetic control of NTSR to acetolactate synthase (ALS) inhibitors in Papaver rhoeas (corn poppy) using progenies from plants with potential NTSR to the imidazolinone herbicide imazamox. NTSR to imazamox was inherited from parents over two successive generations. NTSR to tritosulfuron (a sulfonylurea) was observed in F1 generations and inherited in F2 generations. NTSR to florasulam (a triazolopyrimidine) emerged in F2 generations. Our findings suggest NTSR was polygenic and gradually built-up by accumulation over generations of loci with moderate individual effects in single plants. We also demonstrated that ALS alleles conferring herbicide resistance can co-exist with NTSR loci in P. rhoeas plants. Previous research focussed on TSR in P. rhoeas, which most likely caused underestimation of NTSR significance in this species. This may also apply to other dicot species. From our data, resistance to ALS inhibitors in P. rhoeas appears complex, and involves well-known mutant ALS alleles and a set of unknown NTSR loci that confer resistance to ALS inhibitors from different chemical families. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Management of Hypoparathyroidism: Summary Statement and Guidelines.

PubMed

Brandi, Maria Luisa; Bilezikian, John P; Shoback, Dolores; Bouillon, Roger; Clarke, Bart L; Thakker, Rajesh V; Khan, Aliya A; Potts, John T

2016-06-01

Hypoparathyroidism is a rare disorder characterized by hypocalcemia and absent or deficient PTH. This report presents a summary of current information about epidemiology, presentation, diagnosis, clinical features, and management and proposes guidelines to help clinicians diagnose, evaluate, and manage this disorder. Participants in the First International Conference on the Management of Hypoparathyroidism represented a worldwide constituency with acknowledged interest and expertise in key basic, translational, and clinical aspects of hypoparathyroidism. Three Workshop Panels were constituted to address questions for presentation and discussion at the Conference held in Florence, Italy, May 7-9, 2015. At that time, a series of presentations were made, followed by in-depth discussions in an open forum. Each Workshop Panel also met in closed sessions to formulate the three evidence-based reports that accompany this summary statement. An Expert Panel then considered this information, developed summaries, guidelines, and a research agenda that constitutes this summary statement. Preceding the conference, each Workshop Panel conducted an extensive literature search as noted in the individual manuscripts accompanying this report. All presentations were based upon the best peer-reviewed information taking into account the historical and current literature. This report represents the Expert Panel's synthesis of the conference material placed in a context designed to be relevant to clinicians and those engaged in cutting-edge studies of hypoparathyroidism. This document not only provides a summary of our current knowledge but also places recent advances in its management into a context that should enhance future advances in our understanding of hypoparathyroidism.

NCSE's 15th National Conference and Global Forum on Science, Policy, and the Environment: Energy and Climate Change, Final Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Levine, Ellen

The National Council for Science and the Environment (NCSE) held its 15th National Conference and Global Forum on Science, Policy and the Environment: Energy and Climate Change, on January 27-29, 2015, at the Hyatt Regency Hotel, Crystal City, VA. The National Conference: Energy and Climate Change developed and advanced partnerships that focused on transitioning the world to a new “low carbon” and “climate resilient” energy system. It emphasized advancing research and technology, putting ideas into action, and moving forward on policy and practice. More than 900 participants from the scientific research, policy and governance, business and civil society, and educationmore » communities attended. The Conference was organized around four themes: (1) a new energy system (including energy infrastructure, technologies and efficiencies, changes in distribution of energy sources, and low carbon transportation); (2) energy, climate and sustainable development; (3) financing and markets; and (4) achieving progress (including ideas for the 21st Conference of Parties to the United Nations Framework Convention on Climate Change). The program featured six keynote presentations, six plenary sessions, 41 symposia and 20 workshops. Conference participants were involved in the 20 workshops, each on a specific energy and climate-related issue. The workshops were designed as interactive sessions, with each workshop generating 10-12 recommendations on the topic. The recommendations were prepared in the final conference report, were disseminated nationally, and continue to be available for public use. The conference also featured an exhibition and poster sessions. The National Conference on Energy and Climate Change addressed a wide range of issues specific to the U.S. Department of Energy’s programs; involved DOE’s scientists and program managers in sessions and workshops; and reached out to a broad array of DOE stakeholders.« less

PREFACE: 7th European Conference on Applied Superconductivity (EUCAS '05)

NASA Astrophysics Data System (ADS)

Weber, Harald W.; Sauerzopf, Franz M.

2006-07-01

This issue of Journal of Physics: Conference Series contains those contributed papers that were submitted to the Conference Proceedings of the 7th European Conference on Applied Superconductivity (EUCAS '05) on 11 - 15 September 2005. The plenary and invited papers were published in the journal Superconductor Science and Technology 19 2006 (March issue). The scientific aims of EUCAS '05 followed the tradition established at the preceding conferences in Göttingen, Edinburgh, Eindhoven, Sitges (Barcelona), Lyngby (Copenhagen) and finally Sorrento (Napoli). The focus was placed on the interplay between the most recent developments in superconductor research and the positioning of applications of superconductivity in the marketplace. Although initially founded as an exchange forum mainly for European scientists, it has gradually developed into a truly international meeting with significant attendance from the Far East and the United States. The Vienna conference attracted 813 participants in the scientific programme and 90 guests: of the particpants 59% were from Europe, 31% from the Far East, 6% from the United States and Canada and 4% from other nations worldwide. There were 32 plenary and invited lectures highlighting the state-of-the-art in the areas of materials, large-scale and small-scale applications, and 625 papers were contributed (556 of these were posters) demonstrating the broad range of exciting activities in all research areas of our field. A total of 27 companies presented their most recent developments in the field. This volume contains 349 papers, among them 173 on materials (49.6%), 90 on large scale applications (25.8%) and 86 on small scale applications (24.6%). EUCAS '05 generated a feeling of optimism and enthusiasm for this fascinating field of research and for its well established technological potential, especially among the numerous young researchers attending this Conference. We are grateful to all those who participated in the meeting and contributed to its success. Harald W Weber (Conference Chairman) Franz M Sauerzopf (Conference Secretary)

Innovative Extension Models and Smallholders: How ICT platforms can Deliver Timely Information to Farmers in India.

NASA Astrophysics Data System (ADS)

Nagothu, U. S.

2016-12-01

Agricultural extension services, among others, contribute to improving rural livelihoods and enhancing economic development. Knowledge development and transfer from the cognitive science point of view, is about, how farmers use and apply their experiential knowledge as well as acquired new knowledge to solve new problems. This depends on the models adopted, the way knowledge is generated and delivered. New extension models based on ICT platforms and smart phones are promising. Results from a 5-year project (www.climaadapt.org) in India shows that farmer led-on farm validations of technologies and knowledge exchange through ICT based platforms outperformed state operated linear extension programs. Innovation here depends on the connectivity, net-working between stakeholders that are involved in generating, transferring and using the knowledge. Key words: Smallholders, Knowledge, Extension, Innovation, India

Informatics, evidence-based care, and research; implications for national policy: a report of an American Medical Informatics Association health policy conference.

PubMed

Bloomrosen, Meryl; Detmer, Don E

2010-01-01

There is an increased level of activity in the biomedical and health informatics world (e-prescribing, electronic health records, personal health records) that, in the near future, will yield a wealth of available data that we can exploit meaningfully to strengthen knowledge building and evidence creation, and ultimately improve clinical and preventive care. The American Medical Informatics Association (AMIA) 2008 Health Policy Conference was convened to focus and propel discussions about informatics-enabled evidence-based care, clinical research, and knowledge management. Conference participants explored the potential of informatics tools and technologies to improve the evidence base on which providers and patients can draw to diagnose and treat health problems. The paper presents a model of an evidence continuum that is dynamic, collaborative, and powered by health informatics technologies. The conference's findings are described, and recommendations on terminology harmonization, facilitation of the evidence continuum in a "wired" world, development and dissemination of clinical practice guidelines and other knowledge support strategies, and the role of diverse stakeholders in the generation and adoption of evidence are presented.

Generating Extractive Summaries of Scientific Paradigms (Open Access, Publisher’s Version)

DTIC Science & Technology

2013-02-01

international joint conference on Artifical intelligence , IJCAI’07, pp. 2060–2065. Bassett, D. S., & Bullmore, E. (2006). Small-world brain networks. The...Journal of Artificial Intelligence Research 46 (2013) 165-201 Submitted 7/12; published 2/13 Generating Extractive Summaries of Scientific Paradigms...Whidby and Taesun Moon were supported, in part, by the Intelligence Advanced Research Projects Activity (IARPA) via Department of Interior Na- tional

Advances in systems biology: computational algorithms and applications.

PubMed

Huang, Yufei; Zhao, Zhongming; Xu, Hua; Shyr, Yu; Zhang, Bing

2012-01-01

The 2012 International Conference on Intelligent Biology and Medicine (ICIBM 2012) was held on April 22-24, 2012 in Nashville, Tennessee, USA. The conference featured six technical sessions, one tutorial session, one workshop, and 3 keynote presentations that covered state-of-the-art research activities in genomics, systems biology, and intelligent computing. In addition to a major emphasis on the next generation sequencing (NGS)-driven informatics, ICIBM 2012 aligned significant interests in systems biology and its applications in medicine. We highlight in this editorial the selected papers from the meeting that address the developments of novel algorithms and applications in systems biology.

Noise control in aeroacoustics; Proceedings of the 1993 National Conference on Noise Control Engineering, NOISE-CON 93, Williamsburg, VA, May 2-5, 1993

NASA Astrophysics Data System (ADS)

Hubbard, Harvey H.

In the conference over 100 papers were presented in eight sessions: (1) Emission: Noise Sources; (2) Physical Phenomena; (3) Noise ControlElements; (4) Vibration and Shock: Generation, Transmission, Isolation, and Reduction; (5) Immission: Physical Aspects of Environmental Noise; (6) Immission: Effects of Noise; (7) Analysis; and (8) Requirements. In addition, the distinguished lecture series included presentations on the High Speed Civil Transport and on research from the United Kingdom on aircraft noise effects. For individual titles, see A95-90089 through A95-90141.

Developing a Research Agenda to Optimize Diagnostic Imaging in the Emergency Department: An Executive Summary of the 2015 Academic Emergency Medicine Consensus Conference.

PubMed

Marin, Jennifer R; Mills, Angela M

2015-12-01

The 2015 Academic Emergency Medicine consensus conference, "Diagnostic Imaging in the Emergency Department: A Research Agenda to Optimize Utilization" was held on May 12, 2015, with the goal of developing a high-priority research agenda on which to base future research. The specific aims of the conference were to (1) understand the current state of evidence regarding emergency department (ED) diagnostic imaging use and identify key opportunities, limitations, and gaps in knowledge; (2) develop a consensus-driven research agenda emphasizing priorities and opportunities for research in ED diagnostic imaging; and (3) explore specific funding mechanisms available to facilitate research in ED diagnostic imaging. Over a 2-year period, the executive committee and other experts in the field convened regularly to identify specific areas in need of future research. Six content areas within emergency diagnostic imaging were identified before the conference and served as the breakout groups on which consensus was achieved: clinical decision rules; use of administrative data; patient-centered outcomes research; training, education, and competency; knowledge translation and barriers to imaging optimization; and comparative effectiveness research in alternatives to traditional computed tomography use. The executive committee invited key stakeholders to assist with the planning and to participate in the consensus conference to generate a multidisciplinary agenda. There were a total of 164 individuals involved in the conference and spanned various specialties, including general emergency medicine, pediatric emergency medicine, radiology, surgery, medical physics, and the decision sciences.

PREFACE: 9th International Conference on X-Ray Microscopy

NASA Astrophysics Data System (ADS)

Quitmann, Christoph; David, Christian; Nolting, Frithjof; Pfeiffer, Franz; Stampanoni, Marco

2009-09-01

Conference logo This volume compiles the contributions to the International Conference on X-Ray Microscopy (XRM2008) held on 20-25 July 2008 in Zurich, Switzerland. The conference was the ninth in a series which started in Göttingen in 1984. Over the years the XRM conference series has served as a forum bringing together all relevant players working on the development of methods, building instrumentation, and applying x-ray microscopy to challenging issues in materials science, condensed matter research, environmental science and biology. XRM2008 was attended by about 300 participants who followed 44 oral presentations and presented 220 posters. Conference photograph Figure 1: Participants of the XRM2008 conference gathered in front of the main building of the ETH-Zurich. The conference showed that x-ray microscopy has become a mature field resting on three pillars. The first are workhorse instruments available even to non-specialist users. These exist at synchrotron sources world-wide as well as in laboratories. They allow the application of established microscopy methods to solve scientific projects in areas as diverse as soil science, the investigation of cometary dust particles, magnetic materials, and the analysis of ancient parchments. Examples of all of these projects can be found in this volume. These instruments have become so well understood that now they are also commercially available. The second pillar is the continued development of methods. Methods like stroboscopic imaging, wet cells or high and low temperature environments add versatility to the experiments. Methods like phase retrieval and ptychographic imaging allow the retrieval of information which hitero was thought to be inaccessible. The third pillar is the extension of such instruments and methods to new photon sources. With x-ray free electron lasers on the horizon the XRM community is working to transfer their know-how to these novel sources which will offer unprecedented brightness and time structure, but which at the same time require unprecedented effort to perform the experiment and to extract meaningful information from the data. Resting on these three pillars, the XRM community seems well prepared to solve the scientific questions of today and to help solve even more challenging scientific questions in the future. Many people contributed to the success of XRM2008, first and foremost were the participants with their excellent contributions and through their lively discussions. Organizing the event was made possible due to many helping hands and brains at the organizing institution, the Paul Scherrer Institut. It is our pleasure to thank all of these people. Financial support was given by the Gold Sponsor, XRADIA, by the European Round Table for Synchrotrons and Free Electron Lasers, the Center for Imaging Science and Technology at Zurich, and by the Swiss National Science Foundation. The conference was kindly hosted by ETH Zurich which provided a perfect setting for this venue. We thank all the participants of XRM2008, everybody who helped in the organization and all financial supporters and are looking forward to hearing about further progress during XRM2010 which will be organized by Argonne National Laboratory in Chicago. C Quitmann, C David, F Nolting, F Pfeiffer and M Stampanoni Proceedings Editors Conference photograph Figure 2 View over Zurich and into the alps from the terrace of the ETHZ main building during the XRM2008 reception. Conference photograph Figure 3 Flag tosser and Alphorn blowers in front of the ETH Zurich main building during the XRM2008 opening reception. Conference photograph Figure 4 Industry exhibition in the entrance hall of the ETHZ main building. Conference photograph Figure 5 Lively discussions amongst the conference participants took place during the two poster sessions. Conference photograph Figure 6 Lecture hall with the participants busily discussing between talks. Conference photograph Figure 7 Past and present winners of the Werner Meyer-Ilse Award are joined by Andrea Meyer-Ilse, the wife of the deceased x-ray microscopy pioneer Werner Meyer-Ilse. From left to right: Weilun Chao (winner 2005), Ann Sakdinawat (winner 2008), Piere Thibault (winner 2008), Andrea Meyer-Ilse and M Feser (winner 2002). Conference photograph Figure 8 Reception in the court of Schloss Rapperswil during the XRM2008 conference excursion. Conference photograph Figure 9 Conference participants walking towards the castle of Rapperswil during the conference excursion. Conference photograph Figure 10 Accompanying persons group gathered in the port of Lucerne.

Real-time maritime scene simulation for ladar sensors

NASA Astrophysics Data System (ADS)

Christie, Chad L.; Gouthas, Efthimios; Swierkowski, Leszek; Williams, Owen M.

2011-06-01

Continuing interest exists in the development of cost-effective synthetic environments for testing Laser Detection and Ranging (ladar) sensors. In this paper we describe a PC-based system for real-time ladar scene simulation of ships and small boats in a dynamic maritime environment. In particular, we describe the techniques employed to generate range imagery accompanied by passive radiance imagery. Our ladar scene generation system is an evolutionary extension of the VIRSuite infrared scene simulation program and includes all previous features such as ocean wave simulation, the physically-realistic representation of boat and ship dynamics, wake generation and simulation of whitecaps, spray, wake trails and foam. A terrain simulation extension is also under development. In this paper we outline the development, capabilities and limitations of the VIRSuite extensions.

Rapporteur report: MHD electric power plants

NASA Technical Reports Server (NTRS)

Seikel, G. R.

1980-01-01

Five US papers from the Proceedings of the Seventh International Conference on MHD Electrical Power Generation at the Massachusetts Institute of Technology are summarized. Results of the initial parametric phase of the US effort on the study of potential early commercial MHD plants are reported and aspects of the smaller commercial prototype plant termed the Engineering Test Facility are discussed. The alternative of using a disk geometry generator rather than a linear generator in baseload MHD plants is examined. Closed-cycle as well as open-cycle MHD plants are considered.

Proceedings of the Annual National Conference on Ada Technology (11th), Held at Williamsburg, Virginia on 15-18 March 1993

DTIC Science & Technology

1993-03-18

responsible for the major FAA resource for designing general management and direction of the advanced automation systems. He also company’s overall...Clusters), Air Medals, Army Commendation *Division, Directorate of Combat Medal and Senior Parachutist Badge. * Developments at the Signal Center pieor to...evaluation (T&E) process. More extensive testing is els for various missile subsystems and runs on a required with fewer resources. This paper explores

Translations on Eastern Europe, Political, Sociological, and Military Affairs, Number 1503

DTIC Science & Technology

1978-02-15

secretary and State Council chairman. Kadar, Losonczi Message Budapest MAGYAR HIRLAP in Hungarian 26 Jan 78 p 4 AU ["Greetings Message by Janos Kadar and...delegates of the European Youth and Students Conference in Budapest . "In the face of the continuing arms race the extension of detente to the military...HUNGARY BOLDIZSAR, FRIENDS REACTION TO RETURN OF CROWN RELATED Budapest ELET ES IRODALOM in Hungarian 14 Jan 78 pp 5-6 [Article by Ivan Boldizsar

An experimental investigation of the separating/reattaching flow over a backstep

NASA Technical Reports Server (NTRS)

Jovic, Srboljub

1993-01-01

This progress report covers the grant period from March until the end of January 1993. Extensive data reduction and analysis of single and two-point measurements for a backward-facing experiment were performed. Pertinent results are presented in two conference papers which are appended to this report. The titles of the papers are as follows: (1) 'Two-point correlation measurements in a recovering turbulent boundary layer'; and (2) 'An experimental study on the recovery of a turbulent boundary layer downstream of the reattachment'.

2nd CRISPR Research Conference Berkeley, CA, July 23-25 2009

DOE Office of Scientific and Technical Information (OSTI.GOV)

Banfield, Jillian

The second meeting dedicated to the topic of clustered, regularly interspaced palindromic repeat (CRISPR)-based microbial immunity to viruses was held in Berkeley on July 23 and 25, 2009. The goal of this meeting was to stimulate discussion and advance understanding of the recently described acquired viral resistance system in bacteria and archaea and to explore its relevance in natural populations and communities. The meeting involved around X scientists with a range of backgrounds, with a program designed for extensive discussion.

Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection.

PubMed

Ruiz, Joaquim

2003-05-01

Quinolones are broad-spectrum antibacterial agents, commonly used in both clinical and veterinary medicine. Their extensive use has resulted in bacteria rapidly developing resistance to these agents. Two mechanisms of quinolone resistance have been established to date: alterations in the targets of quinolones, and decreased accumulation due to impermeability of the membrane and/or an overexpression of efflux pump systems. Recently, mobile elements have also been described, carrying the qnr gene, which confers resistance to quinolones.

Preliminary Reports, Memoranda and Technical Notes of the Materials Research Council Summer Conference, La Jolla, California

DTIC Science & Technology

1984-07-01

Faurie U of Illinois 312-996-2141 A.D. Morrison Jet Propulsion Lab 213-354- 7200 A.R. Calawa Lincoln Lab, MIT 617-863-550C Ron Kerber DARPA 202-694...environment can only be assessed following extensive experimentation in space.2 mM Considering the failure of all efforts to suppress, during growth on earth ... earth because of constitutional supercooling effect. For oxide systems, the possibility exists to establish non-wetting configurations and thus to avoid

GLOBECOM '84 - Global Telecommunications Conference, Atlanta, GA, November 26-29, 1984, Conference Record. Volume 1

NASA Astrophysics Data System (ADS)

The subjects discussed are related to LSI/VLSI based subscriber transmission and customer access for the Integrated Services Digital Network (ISDN), special applications of fiber optics, ISDN and competitive telecommunication services, technical preparations for the Geostationary-Satellite Orbit Conference, high-capacity statistical switching fabrics, networking and distributed systems software, adaptive arrays and cancelers, synchronization and tracking, speech processing, advances in communication terminals, full-color videotex, and a performance analysis of protocols. Advances in data communications are considered along with transmission network plans and progress, direct broadcast satellite systems, packet radio system aspects, radio-new and developing technologies and applications, the management of software quality, and Open Systems Interconnection (OSI) aspects of telematic services. Attention is given to personal computers and OSI, the role of software reliability measurement in information systems, and an active array antenna for the next-generation direct broadcast satellite.

Whole-Transcriptome and -Genome Analysis of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates Identifies Downregulation of ethA as a Mechanism of Ethionamide Resistance

PubMed Central

de Welzen, Lynne; Eldholm, Vegard; Maharaj, Kashmeel; Manson, Abigail L.; Earl, Ashlee M.

2017-01-01

ABSTRACT Genetics-based drug susceptibility testing has improved the diagnosis of drug-resistant tuberculosis but is limited by our lack of knowledge of all resistance mechanisms. Next-generation sequencing has assisted in identifying the principal genetic mechanisms of resistance for many drugs, but a significant proportion of phenotypic drug resistance is unexplained genetically. Few studies have formally compared the transcriptomes of susceptible and resistant Mycobacterium tuberculosis strains. We carried out comparative whole-genome transcriptomics of extensively drug-resistant (XDR) clinical isolates using RNA sequencing (RNA-seq) to find novel transcription-mediated mechanisms of resistance. We identified a promoter mutation (t to c) at position −11 (t−11c) relative to the start codon of ethA that reduces the expression of a monooxygenase (EthA) that activates ethionamide. (In this article, nucleotide changes are lowercase and amino acid substitutions are uppercase.) Using a flow cytometry-based reporter assay, we show that the reduced transcription of ethA is not due to transcriptional repression by ethR. Clinical strains harboring this mutation were resistant to ethionamide. Other ethA promoter mutations were identified in a global genomic survey of resistant M. tuberculosis strains. These results demonstrate a new mechanism of ethionamide resistance that can cause high-level resistance when it is combined with other ethionamide resistance-conferring mutations. Our study revealed many other genes which were highly up- or downregulated in XDR strains, including a toxin-antitoxin module (mazF5 mazE5) and tRNAs (leuX and thrU). This suggests that global transcriptional modifications could contribute to resistance or the maintenance of bacterial fitness have also occurred in XDR strains. PMID:28993337

Integration of carbon nanotubes in slot waveguides (Conference Presentation)

NASA Astrophysics Data System (ADS)

Durán-Valdeiglesias, Elena; Zhang, Weiwei; Hoang, Thi Hong Cam; Alonso-Ramos, Carlos; Serna, Samuel; Le Roux, Xavier; Cassan, Eric; Balestrieri, Matteo; Keita, Al-Saleh; Sarti, Francesco; Biccari, Francesco; Torrini, Ughetta; Vinattieri, Anna; Yang, Hongliu; Bezugly, Viktor; Cuniberti, Gianaurelio; Filoramo, Arianna; Gurioli, Massimo; Vivien, Laurent

2016-05-01

Demanding applications such as video streaming, social networking, or web search relay on a large network of data centres, interconnected through optical links. The ever-growing data rates and power consumption inside these data centres are pushing copper links close to their fundamental limits. Optical interconnects are being extensively studied with the purpose of solving these limitations. Among the different possible technology platforms, silicon photonics, due to its compatibility with the CMOS platform, has become one of the preferred solutions for the development of the future generation photonic interconnects. However, the on-chip integration of all photonic and optoelectronic building blocks (sources, modulators and detectors…) is very complex and is not cost-effective due to the various materials involved (Ge for detection, doped Si for modulators and III-V for lasing). Carbon nanotubes (CNTs) are nanomaterials of great interest in photonics thanks to their fundamental optical properties, including near-IR room-temperature foto- and electro- luminescence, Stark effect, Kerr effect and absorption. In consequence, CNTs have the ability to emit, modulate and detect light in the telecommunications wavelength range. Furthermore, they are being extensively developed for new nano-electronics applications. In this work, we propose to use CNTs as active material integrated into silicon photonics for the development of all optoelectronic devices. Here, we report on the development of new integration schemes to couple the light emission from CNTs into optical resonators implemented on the silicon-on-insulator and silicon-nitride-on-insulator platforms. A theoretical and experimental analysis of the light interaction of CNTs with micro-ring resonators based on strip and slot waveguides and slot photonic crystal heterostructure cavities were carried out.

Thiolation mediated pegylation platform to generate functional universal red blood cells.

PubMed

Nacharaju, Parimala; Manjula, Belur N; Acharya, Seetharama A

2007-01-01

The PEGylation that adds an extension arm on protein amino groups with the conservation of their positive charge masks the A and D antigens of erythrocytes efficiently. In the present study, the efficiency of masking the antigens of RBC by PEGylation protocols that do not conserve the charge with and without adding extension arms is compared. The conjugation of PEG-5000 to RBCs through the addition of extension arms masked the D antigen more efficiently than the other protocol. A combination of PEG-5 K and PEG-20 K is needed to mask the A antigen, irrespective of the PEGylation approach. The oxygen affinity of the PEGylated RBCs increased by the extension arm facilitated PEGylation. The protocol involving the conjugation of PEG-chains without adding extension arm did not alter the oxygen affinity of RBCs. A combination of PEGylation protocols is an alternate strategy to generate universal red blood cells with good levels of oxygen affinity.

Developing a Research Agenda to Optimize Diagnostic Imaging in the Emergency Department: An Executive Summary of the 2015 Academic Emergency Medicine Consensus Conference.

PubMed

Marin, Jennifer R; Mills, Angela M

2015-12-01

The 2015 Academic Emergency Medicine (AEM) consensus conference, "Diagnostic Imaging in the Emergency Department: A Research Agenda to Optimize Utilization," was held on May 12, 2015, with the goal of developing a high-priority research agenda on which to base future research. The specific aims of the conference were to: 1) understand the current state of evidence regarding emergency department (ED) diagnostic imaging utilization and identify key opportunities, limitations, and gaps in knowledge; 2) develop a consensus-driven research agenda emphasizing priorities and opportunities for research in ED diagnostic imaging; and 3) explore specific funding mechanisms available to facilitate research in ED diagnostic imaging. Over a 2-year period, the executive committee and other experts in the field convened regularly to identify specific areas in need of future research. Six content areas within emergency diagnostic imaging were identified prior to the conference and served as the breakout groups on which consensus was achieved: clinical decision rules; use of administrative data; patient-centered outcomes research; training, education, and competency; knowledge translation and barriers to imaging optimization; and comparative effectiveness research in alternatives to traditional computed tomography use. The executive committee invited key stakeholders to assist with planning and to participate in the consensus conference to generate a multidisciplinary agenda. There were 164 individuals involved in the conference spanning various specialties, including emergency medicine (EM), radiology, surgery, medical physics, and the decision sciences. This issue of AEM is dedicated to the proceedings of the 16th annual AEM consensus conference as well as original research related to emergency diagnostic imaging. © 2015 by the Society for Academic Emergency Medicine.

PREFACE: 26th Symposium on Plasma Science for Materials (SPSM-26)

NASA Astrophysics Data System (ADS)

2014-06-01

26th Symposium on Plasma Science for Materials (SPSM-26) Takayuki Watanabe The 26th Symposium on Plasma Science for Materials (SPSM-26) was held in Fukuoka, Japan on September 23-24, 2013. SPSM has been held annually since 1988 under the sponsorship of The 153rd Committee on Plasma Materials Science, Japan Society for the Promotion of Science (JSPS). This symposium is one of the major activities of the Committee, which is organized by researchers in academia and industry for the purpose of advancing intersectional scientific information exchange and discussion of science and technology of plasma materials processing. Plasma processing have attracted extensive attention due to their unique advantages, and it is expected to be utilized for a number of innovative industrial applications such as synthesis of high-quality and high-performance nanomaterials. The advantages of plasmas including high chemical reactivity in accordance with required chemical reactions are beneficial for innovative processing. In recent years, plasma materials processing with reactive plasmas has been extensively employed in the fields of environmental issues and biotechnology. This conference seeks to bring different scientific communities together to create a forum for discussing the latest developments and issues. The conference provides a platform for the exploration of both fundamental topics and new applications of plasmas by the contacts between science, technology, and industry. The conference was organized in plenary lectures, invited, contributed oral presentations, and poster sessions. At this meeting, we had 142 participants from 10 countries and 104 presentations, including 11 invited presentations. This year, we arranged special topical sessions that cover Plasma Medicine and Biotechnologies, Business and Academia Cooperation, Plasma with Liquids, Plasma Processes for Nanomaterials, together with Basic, Electronics, and Thermal Plasma sessions. This special issue presents 28 papers that are selected via strict peer-review process from full papers submitted for the proceedings of the conference. The topics range from basic physics and chemistry of plasma processing to a broad variety of materials processing and environmental applications. This proceeding offers an overview on the recent advances in thermal and non-equilibrium plasmas as well as the challenges ahead in the field of plasma research and applications among engineers and scientists. It is an honor to present this volume of Journal of Physics: Conference Series and we deeply thank the authors for their enthusiastic and high-grade contribution. The editors hope that this proceeding will be useful and helpful for deepening our understanding of science and technology of plasma materials processing and also for stimulating further development of the plasma technology. Finally, I would like to thank the organizing committee and organizing secretariat of SPSM-26, and the participants of the conference for contribution to a successful and exciting meeting. The conference was chaired by Prof. Masaharu Shiratani, Kyushu University. I would also like to thank the financial support from The 153rd Committee on Plasma Materials Science. Editors of SPMS-26 Prof Takayuki Watanabe, Kyushu University, Japan Prof Makoto Sekine, Nagoya University, Japan Prof Takanori Ichiki, The University of Tokyo, Japan Prof Masaharu Shiratani, Kyushu University, Japan Prof Akimitsu Hatta, Kochi University of Technology, Japan Sponsors and Supporting Organization: The 153rd Committee on Plasma Materials Science, Japan Society for the Promotion of Science

Rapid Identification of Genetic Modifications in Bacillus anthracis Using Whole Genome Draft Sequences Generated by 454 Pyrosequencing

DTIC Science & Technology

2010-08-25

or intentional genetic modifications that circumvent the targets of the detection assays or in the case of a biological attack using an antibiotic ...genetic changes conferring antibiotic resistance can be deciphered rapidly and accurately using WGS. We demonstrate the utility of Roche 454...Rapid Identification of Genetic Modifications in Bacillus anthracis Using Whole Genome Draft Sequences Generated by 454 Pyrosequencing Peter E. Chen1

Center for High-Frequency Microelectronics

DTIC Science & Technology

1992-08-31

34 IEEE Transactions on Electron Devices, 38, No. 6, pp. 1324-1333, June 1991. 185. C. C. Chen, R. K. Mains and G. I. Haddad, " High - Power Generation in...Weiss, J. Hu and W.-P. Hong, "Electronic 0 Properties of Power High Electron Mobility Transistors," Conference on Ballistic Electrons for Transistors...method at higher frequencies than previously believed. - Calculations of high - power generation modes in Si IMPATT devices in the 100-200 GHz range have

Applied and Environmental Microbiology Gordon Research Conference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wall, Judy D.

2003-11-19

The main objective of the Gordon Research Conference on Applied and Environmental Microbiology was to present and discuss new, fundamental research findings on microorganisms, their activities in the environment, their ecosystem-level effects, and their environmental or commercial applications. To accomplish this goal, knowledge of microbial diversity, interactions and population dynamics was required. The genomic basis of microbial processes, the cycling of naturally occurring and hazardous substances, and methodologies to assess the functional relationships of microorganisms in their habitats were essential for understanding the ecological consequences of microbial activities and the formulation of generalizing principles. In the last decade, molecular technologymore » has revealed that microbial diversity is far more extensive than the limited view obtained from culturing procedures. Great advances in environmental microbiology have resulted from the development and application of molecular approaches to ecology and molecular evolution. A further surprise resulting from the application of these new tools is the blurring of the distinction between pathogenic traits versus those considered non-pathogenic. This year's conference addressed the issues of biodiversity, its development, and the impact of stress on gene selection and expression. In addition microbial metabolic versatility with toxins such as heavy metals, antibiotics, and organic pollutants were discussed. The nine session topics were (1) biodiversity and the bacterial species, (2) mechanisms of biodiversification, (3) biofilms in health and environment, (4) a genomic view of microbial response to stress, (5) microbial use of toxic metals, (6) microbial mineral formation and dissolution, (7) power and limitations of antimicrobials, (8) biodegradation of organic pollutants, and (9) astrobiology. The Conference had an international profile: the Conference Vice-Chair, Dr. Gerard Muyzer, was from The Nether lands, 10 of the 28 speakers and 2 of the 9 discussion leaders were from outside the USA. The program was composed of speakers and discussion leaders (selected through open peer discussion) from a wide range of universities, institutes, government laboratories, and industries. The Conference has traditionally drawn many non-U.S. conferees. In typical Gordon Conference style, the Conference sessions were informal, off the record, and open to all participants for the expression of their views. Meetings were held in the morning and evening. Afternoons were available for participation in small, informal discussion groups. The latest and often unpublished findings were emphasized. Following each evening session, conferees were able to gather in a central location where additional discussion occurred. Poster sessions facilitated informal discussion in the afternoon and evenings. The entire atmosphere of the Conference was designed to foster informal interaction. In fact, publication of a proceedings was not permitted by the Gordon Conferences in order to promote discussion of unpublished data. This type of meeting is a valuable means of disseminating information and ideas in a way that cannot be achieved through the usual channels of publication and presentations at large scientific meetings. The primary criteria for admittance to this Conference were scientific commitment and, implicitly, an interest in active and meaningful participation in the discussions.« less

Physicochemical characteristics of aerosol particles generated during the milling of beryllium silicate ores: implications for risk assessment.

PubMed

Stefaniak, Aleksandr B; Chipera, Steve J; Day, Gregory A; Sabey, Phil; Dickerson, Robert M; Sbarra, Deborah C; Duling, Mathew G; Lawrence, Robert B; Stanton, Marcia L; Scripsick, Ronald C

2008-01-01

Inhalation of beryllium dusts generated during milling of ores and cutting of beryl-containing gemstones is associated with development of beryllium sensitization and low prevalence of chronic beryllium disease (CBD). Inhalation of beryllium aerosols generated during primary beryllium production and machining of the metal, alloys, and ceramics are associated with sensitization and high rates of CBD, despite similar airborne beryllium mass concentrations among these industries. Understanding the physicochemical properties of exposure aerosols may help to understand the differential immunopathologic mechanisms of sensitization and CBD and lead to more biologically relevant exposure standards. Properties of aerosols generated during the industrial milling of bertrandite and beryl ores were evaluated. Airborne beryllium mass concentrations among work areas ranged from 0.001 microg/m(3) (beryl ore grinding) to 2.1 microg/m(3) (beryl ore crushing). Respirable mass fractions of airborne beryllium-containing particles were < 20% in low-energy input operation areas (ore crushing, hydroxide product drumming) and > 80% in high-energy input areas (beryl melting, beryl grinding). Particle specific surface area decreased with processing from feedstock ores to drumming final product beryllium hydroxide. Among work areas, beryllium was identified in three crystalline forms: beryl, poorly crystalline beryllium oxide, and beryllium hydroxide. In comparison to aerosols generated by high-CBD risk primary production processes, aerosol particles encountered during milling had similar mass concentrations, generally lower number concentrations and surface area, and contained no identifiable highly crystalline beryllium oxide. One possible explanation for the apparent low prevalence of CBD among workers exposed to beryllium mineral dusts may be that characteristics of the exposure material do not contribute to the development of lung burdens sufficient for progression from sensitization to CBD. In comparison to high-CBD risk exposures where the chemical nature of aerosol particles may confer higher bioavailability, respirable ore dusts likely confer considerably less. While finished product beryllium hydroxide particles may confer bioavailability similar to that of high-CBD risk aerosols, physical exposure factors (i.e., large particle sizes) may limit development of alveolar lung burdens.

Report on Transmission Cost Allocation for RTOs and Others (Presentation)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coles, L.

2011-06-01

Presented at the MARC 2011 Annual Conference, 6 June 2011, Rapid City, South Dakota. This presentation provides an overview of the latest research findings and policy developments pertaining to cost allocation and new variable generation resources on the power grid.

Telecommunications: Systems & Services. [SITE 2001 Section].

ERIC Educational Resources Information Center

Mumma, Polly, Ed.; Davis, Niki, Ed.

This document contains the following papers on telecommunications systems and services from the SITE (Society for Information Technology & Teacher Education) 2001 Conference: (1) "Developing and Nurturing a Dynamic On-Line Learning Community" (Kathleen Bacer); (2) "A Lecture Generator in the Web" (Jorge Kinoshita); (3)…

The Third International Cloud Condensation Nuclei Workshop. [conference

NASA Technical Reports Server (NTRS)

Kocmond, W. C.; Rogers, C. R. (Editor); Rea, S. W. (Editor)

1981-01-01

Twenty-five instruments were tested, including size characterization devices and two Aitken counters. The test aerosols were supplied to the instruments by an on-line generation system, thereby eliminating the need for storage bags. Cloud condensation chambers and haze chambers are highlighted.

Proceedings - International Conference on Wheel/Rail Load and Displacement Measurement Techniques : January 19-20, 1981

DOT National Transportation Integrated Search

1981-09-01

Measurement of wheel/rail characteristics generates information for improvement of design tools such as model validation, establishment of load spectra and vehicle/track system interaction. Existing and new designs are assessed from evaluation of veh...

Vasohibin-1 is identified as a master-regulator of endothelial cell apoptosis using gene network analysis

PubMed Central

2013-01-01

Background Apoptosis is a critical process in endothelial cell (EC) biology and pathology, which has been extensively studied at protein level. Numerous gene expression studies of EC apoptosis have also been performed, however few attempts have been made to use gene expression data to identify the molecular relationships and master regulators that underlie EC apoptosis. Therefore, we sought to understand these relationships by generating a Bayesian gene regulatory network (GRN) model. Results ECs were induced to undergo apoptosis using serum withdrawal and followed over a time course in triplicate, using microarrays. When generating the GRN, this EC time course data was supplemented by a library of microarray data from EC treated with siRNAs targeting over 350 signalling molecules. The GRN model proposed Vasohibin-1 (VASH1) as one of the candidate master-regulators of EC apoptosis with numerous downstream mRNAs. To evaluate the role played by VASH1 in EC, we used siRNA to reduce the expression of VASH1. Of 10 mRNAs downstream of VASH1 in the GRN that were examined, 7 were significantly up- or down-regulated in the direction predicted by the GRN.Further supporting an important biological role of VASH1 in EC, targeted reduction of VASH1 mRNA abundance conferred resistance to serum withdrawal-induced EC death. Conclusion We have utilised Bayesian GRN modelling to identify a novel candidate master regulator of EC apoptosis. This study demonstrates how GRN technology can complement traditional methods to hypothesise the regulatory relationships that underlie important biological processes. PMID:23324451

Multi-physics analysis of hybrid graphene/semiconductor plasmonic terahertz sources (Conference Presentation)

NASA Astrophysics Data System (ADS)

Nafari, Mona; Aizin, Gregory R.; Jornet, Josep M.

2017-05-01

Wireless data rates have doubled every eighteen months for the last three decades. Following this trend, Terabit-per-second links will become a reality within the next five years. In this context, Terahertz (THz) band (0.1-10 THz) communication is envisioned as a key technology of the next decade. Despite major progress towards developing THz sources, compact signal generators above 1 THz able to efficiently work at room temperature are still missing. Recently, the use of hybrid graphene/semiconductor high-electron-mobility transistors (HEMT) has been proposed as a way to generate Surface Plasmon Polariton (SPP) waves at THz frequencies. Compact size, room-temperature operation and tunability of the graphene layer, in addition to possibility for large scale integration, motivate the exploration of this approach. In this paper, a simulation model of hybrid graphene/semiconductor HEMT-based THz sources is developed. More specifically, first, the necessary conditions for the so-called Dyakonov-Shur instability to arise within the HEMT channel are derived, and the impact of imperfect boundary conditions is analyzed. Second, the required conditions for coupling between a confined plasma wave in the HEMT channel and a SPP wave in graphene are derived, by starting from the coupling analysis between two 2DEG. Multi-physics simulation are conducted by integrating the hydrodynamic equations for the description of the HEMT device with Maxwell's equations for SPP modeling. Extensive results are provided to analyze the impact of different design elements on the THz signal source. This work will guide the experimental fabrication and characterization of the devices.

Ending war against women. CRLP sponsors workshop on violence against women in situations of armed conflict during Beijing + 5 regional conference.

PubMed

Molloy, J

2000-03-01

Sexual violence during armed conflict has been the primary concern in conferences and meetings of international organizations. It has been rightly viewed as a war crime and a violation of women's human rights. In the Economic Commission for Europe conference in January 2000, the issue was discussed extensively. For the part of the Center for Reproductive Law and Policy and the International Women's Health Coalition, they sponsored a workshop addressing women's sexual and reproductive rights in situations of armed conflict. Participants of the workshop shared experiences from the conflicts in Eastern Europe. Reports indicated that affected women experienced rape and domestic violence, and that trafficking of women has escalated. Compounding these factors has decreased the government funding for contraception, abortion, and health education. In addition, the panelists suggested that women's reproductive health and rights could be improved with greater mental and physical health services and stronger social support during wartime. They further recommended that peacekeeping personnel and others pay closer attention to who is perpetrating the violence against women so that prosecutions can take place after the conflict has ended. Moreover, international relief workers should also work to build capacity of local health personnel to meet women's health needs throughout the transition period.

Triglycidylamine Crosslinking of Porcine Aortic Valve Cusps or Bovine Pericardium Results in Improved Biocompatibility, Biomechanics, and Calcification Resistance

PubMed Central

Connolly, Jeanne M.; Alferiev, Ivan; Clark-Gruel, Jocelyn N.; Eidelman, Naomi; Sacks, Michael; Palmatory, Elizabeth; Kronsteiner, Allyson; DeFelice, Suzanne; Xu, Jie; Ohri, Rachit; Narula, Navneet; Vyavahare, Narendra; Levy, Robert J.

2005-01-01

We investigated a novel polyepoxide crosslinker that was hypothesized to confer both material stabilization and calcification resistance when used to prepare bioprosthetic heart valves. Triglycidylamine (TGA) was synthesized via reacting epichlorhydrin and NH3. TGA was used to crosslink porcine aortic cusps, bovine pericardium, and type I collagen. Control materials were crosslinked with glutaraldehyde (Glut). TGA-pretreated materials had shrink temperatures comparable to Glut fixation. However, TGA crosslinking conferred significantly greater collagenase resistance than Glut pretreatment, and significantly improved biomechanical compliance. Sheep aortic valve interstitial cells grown on TGA-pretreated collagen did not calcify, whereas sheep aortic valve interstitial cells grown on control substrates calcified extensively. Rat subdermal implants (porcine aortic cusps/bovine pericardium) pretreated with TGA demonstrated significantly less calcification than Glut pretreated implants. Investigations of extracellular matrix proteins associated with calcification, matrix metalloproteinases (MMPs) 2 and 9, tenascin-C, and osteopontin, revealed that MMP-9 and tenascin-C demonstrated reduced expression both in vitro and in vivo with TGA crosslinking compared to controls, whereas osteopontin and MMP-2 expression were not affected. TGA pretreatment of heterograft biomaterials results in improved stability compared to Glut, confers biomechanical properties superior to Glut crosslinking, and demonstrates significant calcification resistance. PMID:15631995

European Science Notes, volume 40, number 2

NASA Astrophysics Data System (ADS)

Shaffer, L. E.

1986-02-01

ESN is a monthly publication with brief articles on recent developments in European scientific research. Its partial contents are: Biotechnology Research at GBF, and at the Inst. of Technical Chemistry, Univ. of Hanover, West Germany; 7th European Immunology Congress; Biotechnia '85 - First International Congress for Biotechnology; Acoustic Cavitation Generated by Clinical Ultrasound; Advances in Chemical Reaction Dynamics; Geophysics Research in Israel; Fiber Composite Research at Paisley College of Technology, Scotland; A review of International Research on the Physical Metallurgy of Welding; Silicon Metallurgy at the Helsinki Technical Univ.; A Conference on Guided Optical Structures and Their Applications; Optoelectronics Research at Oxford Univ.; and Fractal Conferences in Europe.

1989 IEEE Aerospace Applications Conference, Breckenridge, CO, Feb. 12-17, 1989, Conference Digest

NASA Astrophysics Data System (ADS)

Recent advances in electronic devices for aerospace applications are discussed in reviews and reports. Topics addressed include large-aperture mm-wave antennas, a cross-array radiometer for spacecraft applications, a technique for computing the propagation characteristics of optical fibers, an analog light-wave system for improving microwave-telemetry data communication, and a ground demonstration of an orbital-debris radar. Consideration is given to a verifiable autonomous satellite control system, Inmarsat second-generation satellites for mobile communication, automated tools for data-base design and criteria for their selection, and a desk-top simulation work station based on the DSP96002 microprocessor chip.

Proceedings of the Agent 2002 Conference on Social Agents : Ecology, Exchange, and Evolution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Macal, C., ed.; Sallach, D., ed.

2003-04-10

Welcome to the ''Proceedings'' of the third in a series of agent simulation conferences cosponsored by Argonne National Laboratory and The University of Chicago. The theme of this year's conference, ''Social Agents: Ecology, Exchange and Evolution'', was selected to foster the exchange of ideas on some of the most important social processes addressed by agent simulation models, namely: (1) The translation of ecology and ecological constraints into social dynamics; (2) The role of exchange processes, including the peer dependencies they create; and (3) The dynamics by which, and the attractor states toward which, social processes evolve. As stated in themore » ''Call for Papers'', throughout the social sciences, the simulation of social agents has emerged as an innovative and powerful research methodology. The promise of this approach, however, is accompanied by many challenges. First, modeling complexity in agents, environments, and interactions is non-trivial, and these representations must be explored and assessed systematically. Second, strategies used to represent complexities are differentially applicable to any particular problem space. Finally, to achieve sufficient generality, the design and experimentation inherent in agent simulation must be coupled with social and behavioral theory. Agent 2002 provides a forum for reviewing the current state of agent simulation scholarship, including research designed to address such outstanding issues. This year's conference introduces an extensive range of domains, models, and issues--from pre-literacy to future projections, from ecology to oligopolistic markets, and from design to validation. Four invited speakers highlighted major themes emerging from social agent simulation.« less

2014 Earth System Grid Federation and Ultrascale Visualization Climate Data Analysis Tools Conference Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, Dean N.

2015-01-27

The climate and weather data science community met December 9–11, 2014, in Livermore, California, for the fourth annual Earth System Grid Federation (ESGF) and Ultrascale Visualization Climate Data Analysis Tools (UV-CDAT) Face-to-Face (F2F) Conference, hosted by the Department of Energy, National Aeronautics and Space Administration, National Oceanic and Atmospheric Administration, the European Infrastructure for the European Network of Earth System Modelling, and the Australian Department of Education. Both ESGF and UVCDATremain global collaborations committed to developing a new generation of open-source software infrastructure that provides distributed access and analysis to simulated and observed data from the climate and weather communities.more » The tools and infrastructure created under these international multi-agency collaborations are critical to understanding extreme weather conditions and long-term climate change. In addition, the F2F conference fosters a stronger climate and weather data science community and facilitates a stronger federated software infrastructure. The 2014 F2F conference detailed the progress of ESGF, UV-CDAT, and other community efforts over the year and sets new priorities and requirements for existing and impending national and international community projects, such as the Coupled Model Intercomparison Project Phase Six. Specifically discussed at the conference were project capabilities and enhancements needs for data distribution, analysis, visualization, hardware and network infrastructure, standards, and resources.« less

Information Technology Architectures. New Opportunities for Partnering, CAUSE94. Track VI.

ERIC Educational Resources Information Center

CAUSE, Boulder, CO.

Eight papers are presented from the 1994 CAUSE conference track on information technology architectures as applied to higher education institutions. The papers include: (1) "Reshaping the Enterprise: Building the Next Generation of Information Systems Through Information Architecture and Processing Reengineering," which notes…

Numerical grid generation techniques. [conference

NASA Technical Reports Server (NTRS)

1980-01-01

The state of the art in topology and flow geometry is presented. Solution techniques for partial differential equations are reviewed and included developments in coordinate transformations, conformal mapping, and invariant imbeddings. Applications of these techniques in fluid mechanics, flow geometry, boundary value problems, and fluidics are presented.

Recipes for Semantic Web Dog Food — The ESWC and ISWC Metadata Projects

NASA Astrophysics Data System (ADS)

Möller, Knud; Heath, Tom; Handschuh, Siegfried; Domingue, John

Semantic Web conferences such as ESWC and ISWC offer prime opportunities to test and showcase semantic technologies. Conference metadata about people, papers and talks is diverse in nature and neither too small to be uninteresting or too big to be unmanageable. Many metadata-related challenges that may arise in the Semantic Web at large are also present here. Metadata must be generated from sources which are often unstructured and hard to process, and may originate from many different players, therefore suitable workflows must be established. Moreover, the generated metadata must use appropriate formats and vocabularies, and be served in a way that is consistent with the principles of linked data. This paper reports on the metadata efforts from ESWC and ISWC, identifies specific issues and barriers encountered during the projects, and discusses how these were approached. Recommendations are made as to how these may be addressed in the future, and we discuss how these solutions may generalize to metadata production for the Semantic Web at large.

Smallpox subunit vaccine produced in planta confers protection in mice

PubMed Central

Golovkin, Maxim; Spitsin, Sergei; Andrianov, Vyacheslav; Smirnov, Yuriy; Xiao, Yuhong; Pogrebnyak, Natalia; Markley, Karen; Brodzik, Robert; Gleba, Yuri; Isaacs, Stuart N.; Koprowski, Hilary

2007-01-01

We report here the in planta production of the recombinant vaccinia virus B5 antigenic domain (pB5), an attractive component of a subunit vaccine against smallpox. The antigenic domain was expressed by using efficient transient and constitutive plant expression systems and tested by various immunization routes in two animal models. Whereas oral administration in mice or the minipig with collard-derived insoluble pB5 did not generate an anti-B5 immune response, intranasal administration of soluble pB5 led to a rise of B5-specific immunoglobulins, and parenteral immunization led to a strong anti-B5 immune response in both mice and the minipig. Mice immunized i.m. with pB5 generated an antibody response that reduced virus spread in vitro and conferred protection from challenge with a lethal dose of vaccinia virus. These results indicate the feasibility of producing safe and inexpensive subunit vaccines by using plant production systems. PMID:17428917

Comparing Safety and Efficacy of "Third-Generation" Antiepileptic Drugs: Long-Term Extension and Post-marketing Treatment.

PubMed

Kwok, Charlotte S; Johnson, Emily L; Krauss, Gregory L

2017-11-01

Four "third-generation" antiepileptic drugs (AEDs) were approved for adjunctive treatment of refractory focal onset seizures during the past 10 years. Long-term efficacy and safety of the drugs were demonstrated in large extension studies and in reports of subgroups of patients not studied in pivotal trials. Reviewing extension study and post-marketing outcome series for the four newer AEDs-lacosamide, perampanel, eslicarbazepine acetate and brivaracetam-can guide clinicians in treating and monitoring patients. AED extension studies evaluate treatment retention, drug tolerability, and drug safety during individualized treatment with flexible dosing and thus provide information not available in rigid pivotal trials. Patient retention in the studies ranged from 75 to 80% at 1 year and from 36 to 68% at 2-year treatment intervals. Safety findings were generally similar to those of pivotal trials, with no major safety risks identified and with several specific adverse drug effects, such as hyponatremia, reported. The third-generation AEDs, some through new mechanisms and others with improved tolerability compared to related AEDs, provide new options in efficacy and tolerability.

PREFACE: 21th International Conference for Students and Young Scientists: Modern Technique and Technologies (MTT'2015)

NASA Astrophysics Data System (ADS)

2015-10-01

Involving young researchers in the scientific process, and allowing them to gain scientific experience, are important issues for scientific development. The International Conference for Students and Young Scientists ''Modern Technique and Technologies'' is one of a number of scientific events, held at National Research Tomsk Polytechnic University aimed at training and forming the scientific elite. During previous years the conference established itself as a serious scientific event at an international level, attracting members which annually number about 400 students and young scientists from Russia and near and far abroad. An important indicator of this scientific event is the large number of scientific areas covered, such as power engineering, heat power engineering, electronic devices for monitoring and diagnostics, instrumentation, materials and technologies of new generations, methods of research and diagnostics of materials, automatic control and system engineering, physical methods science and engineering, design and artistic aspects of engineering, social and humanitarian aspects of engineering. The main issues, which are discussed at the conference by young researchers, are connected with analysis of contemporary problems, application of new techniques and technologies, and consideration of their relationship. Over the years, the conference committee has gained a lot of experience in organizing scientific meetings. There are all the necessary conditions: the staff of organizers includes employees of Tomsk Polytechnic University; the auditoriums are equipped with modern demonstration and office equipment; leading scientists are TPU professors; the status of the Tomsk Polytechnic University as a leading research university in Russia also plays an important role. All this allows collaboration between leading scientists from all around the world, who are annually invited to give lectures at the conference. The editorial board expresses gratitude to the Administration of Tomsk Polytechnic University (TPU Rector, Professor P.S. Chubik and Vice Rector for Research and Innovation, Professor A.N. Dyachenko) for financial support of the conference. Also, we heartily thank both chairmen of the conference sections and the organizing committee's members for the great, effective, creative work in organizing and developing the conference as well as a significant contribution to the safeguarding and replenishment of the intellectual potential of Russia.

Novel interactions of ankyrins-G at the costameres: The muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds plectin and filamin C

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maiweilidan, Yimingjiang; Klauza, Izabela; Kordeli, Ekaterini, E-mail: ekaterini.kordeli@inserm.fr

2011-04-01

Ankyrins, the adapters of the spectrin skeleton, are involved in local accumulation and stabilization of integral proteins to the appropriate membrane domains. In striated muscle, tissue-dependent alternative splicing generates unique Ank3 gene products (ankyrins-G); they share the Obscurin/Titin-Binding-related Domain (OTBD), a muscle-specific insert of the C-terminal domain which is highly conserved among ankyrin genes, and binds obscurin and titin to Ank1 gene products. We previously proposed that OTBD sequences constitute a novel domain of protein-protein interactions which confers ankyrins with specific cellular functions in muscle. Here we searched for muscle proteins binding to ankyrin-G OTBD by yeast two hybrid assay,more » and we found plectin and filamin C, two organizing elements of the cytoskeleton with essential roles in myogenesis, muscle cell cytoarchitecture, and muscle disease. The three proteins coimmunoprecipitate from skeletal muscle extracts and colocalize at costameres in adult muscle fibers. During in vitro myogenesis, muscle ankyrins-G are first expressed in postmitotic myocytes undergoing fusion to myotubes. In western blots of subcellular fractions from C2C12 cells, the majority of muscle ankyrins-G appear associated with membrane compartments. Occasional but not extensive co-localization at nascent costameres suggested that ankyrin-G interactions with plectin and filamin C are not involved in costamere assembly; they would rather reinforce stability and/or modulate molecular interactions in sarcolemma microdomains by establishing novel links between muscle-specific ankyrins-G and the two costameric dystrophin-associated glycoprotein and integrin-based protein complexes. These results report the first protein-protein interactions involving the ankyrin-G OTBD domain and support the hypothesis that OTBD sequences confer ankyrins with a gain of function in vertebrates, bringing further consolidation and resilience of the linkage between sarcomeres and sarcolemma.« less

Knowledge gaps in the diagnosis and management of patients with tropical diseases presenting to Canadian emergency departments: are the gaps being met?

PubMed

Meshkat, Nazanin; Misra, Shikha; Hunchak, Cheryl; Cleiman, Paula; Khan, Yasmin; Puchalski Ritchie, Lisa M

2014-11-01

We conducted a needs assessment to identify knowledge gaps in the management of tropical diseases by Canadian emergency physicians and identify available, related continuing medical education (CME) resources. A literature review was conducted to summarize challenges in the management of commonly encountered tropical diseases. An anonymous online survey was administered to Canadian emergency physicians using the Canadian Association of Emergency Physicians survey deployment service in July and August 2012. The survey identified self-reported gaps in knowledge and assessed knowledge using case-based vignettes. A list of CME resources was generated from a review of major academic emergency medicine journals, online cases, and conference topics from emergency medicine associations during 2010-2011. Two independent reviewers assessed the relevance of the resources; differences were resolved by consensus. From 635 citations, 47 articles were selected for full review; the majority (66%) were retrospective chart reviews, few (10.6%) had an emergency medicine focus, and fewer still were Canadian (8.5%). In total, 1,128 surveys were distributed, and 296 (27%) participants were included in the study. Most respondents reported "no" (52.4%) or "some" (45.9%) training in tropical medicine. Most (69.9%) rated their comfort in managing patients with tropical diseases as "low." Few (11.1%) respondents reported a tropical disease being misdiagnosed or mismanaged; 44.1% indicated malaria. The perceived need for further training was high (76.7%). Conference workshops were the most highly requested CME modality, followed by case studies and podcasts. Correct answers to case vignettes ranged from 30.7 to 58.4%. Although 2,038 CME titles were extracted from extensive searches, only 6 were deemed relevant. Most Canadian emergency physicians have had minimal training in tropical diseases, reported a low comfort level in their management, and identified a high need for CME opportunities, which are lacking.

The Minnesota Maple Series: Community-Generated Knowledge Delivered through an Extension Website

ERIC Educational Resources Information Center

Wilsey, David S.; Miedtke, Juile A.; Sagor, Eli

2012-01-01

Extension continuously seeks novel and effective approaches to outreach and education. The recent retirement of a longtime content specialist catalyzed members of University of Minnesota Extension's Forestry team to reflect on our instructional capacity (internal and external) and educational design in the realm of maple syrup production. We…

Nonlinear Dynamics in Optical Systems. Postdeadline Papers Presented at the Optical Society of America Conference Held in Alpbach, Austria on June 22- 26, 1992

DTIC Science & Technology

1992-06-26

periodically, at a period deternined by an external synchronizing pulse generator . The sampled signal is input to the laser diode driver for a time short...eigenmodes which correspond to stable/unstable manifolds. At the pa- rameters A = 540’ D = 0.001 and K 0 = 2.2, for example, the full model generates ...optics: generation and interaction of spatiotemporal structures", J. Opt. Soc. Am. B 9, 78-90 (1992). 3 N. 1. Zheleznykh, M. A. Vorontsov and A- V

US PWR steam generator management: An overview

DOE Office of Scientific and Technical Information (OSTI.GOV)

Welty, C.S. Jr.

1997-02-01

This paper provides an overview on the status of steam generator management activities in US PWRs, and includes: (1) an overview of the impact of steam generator problems; (2) a brief discussion of historical damage trends and the current damage mechanism of most concern; (3) a discussion of the elements of {open_quotes}steam generator management{close_quotes}; and (4) a description of the approach being followed to implement a degradation-specific protocol for tubing inspection and repair. This paper was prepared in conjunction with another paper presented during the Plenary Session of this Conference, {open_quotes}Steam Generator Degradation: Current Mitigation Strategies for Controlling Corrosion{close_quotes}, andmore » is provided as a supplement to that material.« less

PREFACE: 11th International Conference on X-ray Microscopy (XRM2012)

NASA Astrophysics Data System (ADS)

Xu, Hongjie; Wu, Ziyu; Tai, Renzhong

2013-10-01

The Eleventh International Conference on X-ray Microscopy (XRM2012) was held on 5-10 August 2012 at the Hope hotel in Shanghai. Historically, for the first time the XRM conference took place in China. The conference was jointly hosted by the Shanghai Synchrotron Radiation Facility (SSRF) and the National Synchrotron Radiation Laboratory (NSRL). The series of XRM conferences dates back to 1983 in Göttingen, Germany. Since the Zürich conference, XRM2008, it has been held every two years, showing its increasing popularity among the x-ray microscopy communities around the world. Research in the area of x-ray microscopy is advancing very fast with the development of synchrotron radiation techniques, especially the emergence of third generation light sources with low natural emittance which has significantly pushed forward the development of technologies and applications in this area. This has been fully demonstrated in presentations from this and previous XRM conferences. XRM2012 was attended by 295 people including 21 invited speakers, 53 contributing speakers, 55 students, and 13 industry exhibitors. Over 232 abstracts were submitted for oral or poster presentation and 56 original, peer-reviewed papers are published in these proceedings. The conference was sponsored by the Chinese Academy of Sciences (CAS) and the National Natural Science Foundation of China (11210301016/A0802), and three gold sponsors active in industrial and technological fields related to x-ray microscopy. An exhibition booth was offered free to Australia synchrotron, the host for XRM2014, to promote the next conference which will be held in Melbourne, Australia in 2014. An unforgettable memory for most conference participants might be the charming night cruise along Pujiang river which was part of the welcome reception on the first evening. The Werner Meyer-Ilse Award (WMIA) prize this year was awarded to Irene Zanette (TU-München) and Stephan Werner (HZB-Berlin), the former for her pioneering new work in high-sensitivity phase-contrast and dark-field (small-angle x-ray scattering) images, the latter for his outstanding accomplishments in the field of on-chip zone plate stacking. The location for the XRM2016 conference was voted for by all conference attendees, and Diamond Light Source in the United Kingdom was chosen. A tour of SSRF was attended by nearly 100 participants who got a close look at the seven beamlines in operation before the close of the meeting. We would like to thank all the participants for their active involvement and excellent contributions during the conference and poster session, and the International Program Committee for their guidance, and outstanding support of local organizating committee for a successful XRM2012. Hongjie Xu, Ziyu Wu and Renzhong Tai Proceeding Editors Logos Conference photograph The PDF file also contains a number of photographs taken at the conference and lists of committes and participants.

PREFACE: 23rd International Conference on High Pressure Science and Technology (AIRAPT-23)

NASA Astrophysics Data System (ADS)

Gupta, Satish C.

2012-07-01

The 23rd AIRAPT International Conference on High Pressure Science and Technology was held at Bhabha Atomic Research Centre, Mumbai, from 25-30 September 2011. This conference is part of the series of AIRAPT International Conferences which are held biennially. AIRAPT is an acronym for the French title which translates as 'International Association for the Advancement of High Pressure Science and Technology'. This was the second time the AIRAPT Conference was organized in India. The first was held 20 years ago at the National Aeronautical Laboratory, Bangalore in 1991. The 23rd Conference covered many important topics in the area of both static and dynamic high pressures including theoretical and experimental investigations on the response of materials under high pressures, new developments using neutron and synchrotron sources, investigations on superconductivity under high pressure, studies of geophysical and planetary sciences, biosciences, and the synthesis of new materials. The conference program included Bridgman award lecture, Jemieson award lecture, seven plenary talks, 85 invited talks, 83 oral presentations and about 195 posters. In all there were 372 presentations. 285 scientists from 19 countries participated in the conference. The countries represented included Austria, Canada, China, Estonia, France, Germany, India, Israel, Italy, Japan, Nepal, New Zealand, Poland, Russia, South Korea, Spain, Sweden, Switzerland, Turkey, UK, Ukraine and USA. Many new developments were presented, for example, measurement techniques using the new generation synchrotron sources, more powerful neutron sources and much brighter laser sources; integration of gas-gun with synchrotron source; the achievement of multi-megabar pressures in shock-less dynamic compressions; and capabilities to synthesize centimeter size diamonds with better quality. All these developments have opened up new opportunities for understanding the physics of materials under high pressures. I would like to thank all those who have made valuable contributions to the success of the conference, which include the members of the AIRAPT executive committee, the International Advisory Committee and National Advisory Committee, the plenary speakers, invited speakers, the chairmen of various sessions, all the participants, and the authors of the papers in this volume. All the papers accepted for the proceedings have been reviewed by two independent referees. I am extremely thankful to all the anonymous referees, who have spent their valuable time to ensure the quality of the papers of this volume. I wish to express my gratitude to the members of the Local Organizing Committee for their help and hard work for the success of the conference. Finally, I convey my special thanks to Dr T C Kaushik and Dr K D Joshi, who worked tirelessly and enthusiastically towards making this conference a success. I am confident that this volume of the Conference proceedings will provide an excellent source of information on the current trends in the field of High Pressure Science and Technology. Satish C Gupta Conference Chairman 25-30 September 2011 Conference logo Conference photograph

Method and apparatus for steam mixing a nuclear fueled electricity generation system

DOEpatents

Tsiklauri, Georgi V.; Durst, Bruce M.

1996-01-01

A method and apparatus for improving the efficiency and performance of a nuclear electrical generation system that comprises the addition of steam handling equipment to an existing plant that results in a surprising increase in plant performance. More particularly, a gas turbine electrical generation system with heat recovery boiler is installed along with a micro-jet high pressure and a low pressure mixer superheater. Depending upon plant characteristics, the existing moisture separator reheater (MSR) can be either augmented or done away with. The instant invention enables a reduction in T.sub.hot without a derating of the reactor unit, and improves efficiency of the plant's electrical conversion cycle. Coupled with this advantage is a possible extension of the plant's fuel cycle length due to an increased electrical conversion efficiency. The reduction in T.sub.hot further allows for a surprising extension of steam generator life. An additional advantage is the reduction in erosion/corrosion of secondary system components including turbine blades and diaphragms. The gas turbine generator used in the instant invention can also replace or augment existing peak or emergency power needs. Another benefit of the instant invention is the extension of plant life and the reduction of downtime due to refueling.

Vibrational imaging of glucose uptake activity in live cells and tissues by stimulated Raman scattering microscopy (Conference Presentation)

NASA Astrophysics Data System (ADS)

Hu, Fanghao; Chen, Zhixing; Zhang, Luyuan; Shen, Yihui; Wei, Lu; Min, Wei

2016-03-01

Glucose is consumed as an energy source by virtually all living organisms, from bacteria to humans. Its uptake activity closely reflects the cellular metabolic status in various pathophysiological transformations, such as diabetes and cancer. Extensive efforts such as positron emission tomography, magnetic resonance imaging and fluorescence microscopy have been made to specifically image glucose uptake activity but all with technical limitations. Here, we report a new platform to visualize glucose uptake activity in live cells and tissues with subcellular resolution and minimal perturbation. A novel glucose analogue with a small alkyne tag (carbon-carbon triple bond) is developed to mimic natural glucose for cellular uptake, which can be imaged with high sensitivity and specificity by targeting the strong and characteristic alkyne vibration on stimulated Raman scattering (SRS) microscope to generate a quantitative three dimensional concentration map. Cancer cells with differing metabolic characteristics can be distinguished. Heterogeneous uptake patterns are observed in tumor xenograft tissues, neuronal culture and mouse brain tissues with clear cell-cell variations. Therefore, by offering the distinct advantage of optical resolution but without the undesirable influence of bulky fluorophores, our method of coupling SRS with alkyne labeled glucose will be an attractive tool to study energy demands of living systems at the single cell level.

Network-assisted investigation of virulence and antibiotic-resistance systems in Pseudomonas aeruginosa

NASA Astrophysics Data System (ADS)

Hwang, Sohyun; Kim, Chan Yeong; Ji, Sun-Gou; Go, Junhyeok; Kim, Hanhae; Yang, Sunmo; Kim, Hye Jin; Cho, Ara; Yoon, Sang Sun; Lee, Insuk

2016-05-01

Pseudomonas aeruginosa is a Gram-negative bacterium of clinical significance. Although the genome of PAO1, a prototype strain of P. aeruginosa, has been extensively studied, approximately one-third of the functional genome remains unknown. With the emergence of antibiotic-resistant strains of P. aeruginosa, there is an urgent need to develop novel antibiotic and anti-virulence strategies, which may be facilitated by an approach that explores P. aeruginosa gene function in systems-level models. Here, we present a genome-wide functional network of P. aeruginosa genes, PseudomonasNet, which covers 98% of the coding genome, and a companion web server to generate functional hypotheses using various network-search algorithms. We demonstrate that PseudomonasNet-assisted predictions can effectively identify novel genes involved in virulence and antibiotic resistance. Moreover, an antibiotic-resistance network based on PseudomonasNet reveals that P. aeruginosa has common modular genetic organisations that confer increased or decreased resistance to diverse antibiotics, which accounts for the pervasiveness of cross-resistance across multiple drugs. The same network also suggests that P. aeruginosa has developed mechanism of trade-off in resistance across drugs by altering genetic interactions. Taken together, these results clearly demonstrate the usefulness of a genome-scale functional network to investigate pathogenic systems in P. aeruginosa.

Study and Demonstration of Planning and Scheduling Concepts for the Earth Observing System Data and Information System

NASA Technical Reports Server (NTRS)

Davis, Randal; Thalman, Nancy

1993-01-01

The University of Colorado's Laboratory for Atmospheric and Space Physics (CU/LASP) along with the Goddard Space Flight Center (GSFC) and the Jet Propulsion Laboratory (JPL) designed, implemented, tested, and demonstrated a prototype of the distributed, hierarchical planning and scheduling system comtemplated for the Earth Observing System (EOS) project. The planning and scheduling prototype made use of existing systems: CU/LASP's Operations and Science Instrument Support Planning and Scheduling (OASIS-PS) software package; GSFC's Request Oriented Scheduling Engine (ROSE); and JPL's Plan Integrated Timeliner 2 (Plan-It-2). Using these tools, four scheduling nodes were implemented and tied together using a new communications protocol for scheduling applications called the Scheduling Applications Interface Language (SAIL). An extensive and realistic scenario of EOS satellite operations was then developed and the prototype scheduling system was tested and demonstrated using the scenario. Two demonstrations of the system were given to NASA personnel and EOS core system (ECS) contractor personnel. A comprehensive volume of lessons learned was generated and a meeting was held with NASA and ECS representatives to review these lessons learned. A paper and presentation on the project's final results was given at the American Institute of Aeronautics and Astronautics Computing in Aerospace 9 conference.

Immersion lithography: its history, current status and future prospects

NASA Astrophysics Data System (ADS)

Owa, Soichi; Nagasaka, Hiroyuki

2008-11-01

Since the 1980's, immersion exposure has been proposed several times. At the end of 1990's, however, these concepts were almost forgotten because other technologies, such as electron beam projection, EUVL, and 157 nm were believed to be more promising than immersion exposures. The current work in immersion lithography started in 2001 with the report of Switkes and Rothschild. Although their first proposal was at 157 nm wavelength, their report in the following year on 193 nm immersion with purified water turned out to be the turning point for the introduction of water-based 193 nm immersion lithography. In February, 2003, positive feasibility study results of 193 nm immersion were presented at the SPIE microlithography conference. Since then, the development of 193 nm immersion exposure tools accelerated. Currently (year 2008), multiple hyper NA (NA>1.0) scanners are generating mass production 45 nm half pitch devices in semiconductor manufacturing factories. As a future extension, high index immersion was studied over the past few years, but material development lagged more than expected, which resulted in the cancellation of high index immersion plans at scanner makers. Instead, double patterning, double dipole exposure, and customized illuminations techniques are expected as techniques to extend immersion for the 32 nm node and beyond.

Hitting bacteria at the heart of the central dogma: sequence-specific inhibition.

PubMed

Rasmussen, Louise Carøe Vohlander; Sperling-Petersen, Hans Uffe; Mortensen, Kim Kusk

2007-08-10

An important objective in developing new drugs is the achievement of high specificity to maximize curing effect and minimize side-effects, and high specificity is an integral part of the antisense approach. The antisense techniques have been extensively developed from the application of simple long, regular antisense RNA (asRNA) molecules to highly modified versions conferring resistance to nucleases, stability of hybrid formation and other beneficial characteristics, though still preserving the specificity of the original nucleic acids. These new and improved second- and third-generation antisense molecules have shown promising results. The first antisense drug has been approved and more are in clinical trials. However, these antisense drugs are mainly designed for the treatment of different human cancers and other human diseases. Applying antisense gene silencing and exploiting RNA interference (RNAi) are highly developed approaches in many eukaryotic systems. But in bacteria RNAi is absent, and gene silencing by antisense compounds is not nearly as well developed, despite its great potential and the intriguing possibility of applying antisense molecules in the fight against multiresistant bacteria. Recent breakthrough and current status on the development of antisense gene silencing in bacteria including especially phosphorothioate oligonucleotides (PS-ODNs), peptide nucleic acids (PNAs) and phosphorodiamidate morpholino oligomers (PMOs) will be presented in this review.

Extension of supercontinuum spectrum, generated in polarization-maintaining photonic crystal fiber, using chirped femtosecond pulses

NASA Astrophysics Data System (ADS)

Vengelis, Julius; Jarutis, Vygandas; Sirutkaitis, Valdas

2018-01-01

We present results of experimental and numerical investigation of supercontinuum (SC) generation in polarization-maintaining photonic crystal fiber (PCF) using chirped femtosecond pulses. The initial unchirped pump pulse source was a mode-locked Yb:KGW laser generating 52-nJ energy, 110-fs duration pulses at 1030 nm with a 76-MHz repetition rate. The nonlinear medium was a 32-cm-long polarization-maintaining PCF manufactured by NKT Photonics A/S. We demonstrated the influence of pump pulse chirp on spectral characteristics of a SC. We showed that by chirping pump pulses positively or negatively one can obtain a broader SC spectrum than in the case of unchirped pump pulses at the same peak power. Moreover, the extension can be controlled by changing the amount of pump pulse chirp. Numerical simulation results also indicated that pump pulse chirp yields an extension of SC spectrum.

Locomotive forces produced by single leukocytes in vivo and in vitro.

PubMed

Guilford, W H; Lantz, R C; Gore, R W

1995-05-01

We report here the first time-resolved measurements of the forces produced during the migration of single leukocytes in vivo and in vitro. Pulmonary macrophages from hamsters and mice, in vitro, and Nembutal (pentobarbital sodium)-anesthetized hamster neutrophils, in vivo, generated maximum locomotive forces ranging from 1.9 to 10.7 nN or tenths of microdynes. Force production was periodic and correlated with the length of the leading lamellipod but not with generalized cell ruffling. Although the extension of the leading lamella is critical to locomotive force generation, these direct measurements suggest that lamellar extension may not arise from the same contractile processes driving forward motion of the cell mass. Indeed, cell ruffling, lamellar extension, and locomotive force generation may be differentially controlled and have different origins. This technique may be extended to test numerous hypotheses of how these and other nonmuscle cells crawl.

76 FR 5218 - Advisory Committee on Reactor Safeguards

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-28

..., October 21, 2010 (74 FR 65038-65039). Thursday, February 10, 2011, Conference Room T2-B1, 11545 Rockville... Evaluation Report Associated with the License Renewal Application for the Palo Verde Nuclear Generating... NRC staff and Arizona Public Service Company regarding the final Safety Evaluation Report associated...

READINGS IN INTERGROUP RELATIONS.

ERIC Educational Resources Information Center

STOREN, HELEN F.

NOTING THAT THE FIELD OF HUMAN RELATIONS HAS RECEIVED MORE ATTENTION IN THE LAST GENERATION THAN EVER BEFORE, THE NATIONAL CONFERENCE OF CHRISTIANS AND JEWS HAS REVISED ITS 1956 EDITION OF SELECTED READING LITERATURE. READINGS ARE DIVIDED INTO SEVEN CATEGORIES--PREJUDICE - CAUSES, PREVENTION AND CURE, RELIGION - UNDERSTANDING RELIGIOUS GROUPS,…

Forecast of the World's Electrical Demands until 2025.

ERIC Educational Resources Information Center

Claverie, Maurice J.; Dupas, Alain P.

1979-01-01

Models of global energy demand, a lower-growth-rate model developed at Case Western Reserve University and the H5 model of the Conservation Committee of the World Energy Conference, assess the features of decentralized and centralized electricity generation in the years 2000 and 2025. (BT)

Development of the Next Generation of Adaptive Interfaces

DTIC Science & Technology

2015-03-01

References Drury JL, Riek L, Rackliffe N. A decomposition of UAV-related situation awareness. Proceedings of Human- Robot Interaction Conference, Salt Lake...317 FORT BELVOIR VA 22060-5828 1 ARMY RSCH LABORATORY – HRED (PDF) RDRL HRM AY M BARNES 2520 HEALY AVE STE 1172 BLDG 51005

An Emergent Framework: Views of Mathematical Processes

ERIC Educational Resources Information Center

Sanchez, Wendy B.; Lischka, Alyson E.; Edenfield, Kelly W.; Gammill, Rebecca

2015-01-01

The findings reported in this paper were generated from a case study of teacher leaders at a state-level mathematics conference. Investigation focused on how participants viewed the mathematical processes of communication, connections, representations, problem solving, and reasoning and proof. Purposeful sampling was employed to select nine…

77 FR 11109 - Reactive Power Resources; Notice of Technical Conference

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-24

... options for and cost of installing reactive power equipment at the time of interconnection as well as... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. AD12-10-000] Reactive Power... the need for reactive power capability among newly interconnecting asynchronous generators and raises...

Developing Leadership: Creating the Schools of Tomorrow. Professional Learning

ERIC Educational Resources Information Center

Coles, Martin, Ed.; Southworth, Geoff, Ed.

2004-01-01

The idea for this book grew out of an international conference organized by the National College for School Leadership, An International Future: Learning from best practice worldwide, which explored innovative and significant aspects of educational leadership and brought together international colleagues to generate new understandings. The…

Bishop plays down report on condoms / AIDS in France.

PubMed

1996-02-26

Individual bishops in France and other European countries have argued that condom use can save lives by preventing the spread of HIV. The French Bishops' Conference social commission published a 200-page report which in which agreement was expressed with widespread medical opinion that condom use is the sole and necessary barrier against the sexual spread of HIV. Extensive media coverage ensued and led to Bishop Albert Rouet, the bishop of Poitiers and chairman of the French Bishops' Conference, being interviewed by the Holy See's official radio. In the interview, Bishop Rouet distanced the Roman Catholic Church in France from the report, claiming that the media had exaggerated the issue and that his commission was not bound by the reference. The Vatican remains staunchly opposed to condom use against HIV infection and preaches abstinence outside of marriage and fidelity within marriage as the only true ways to avoid HIV infection. In 1995, the Vatican fired Jacques Gaillot, the former bishop of Evreux in Normandy, for his outspoken endorsement of condom use against HIV.

Outcome of the second Medicines Utilisation Research in Africa Group meeting to promote sustainable and appropriate medicine use in Africa.

PubMed

Massele, Amos; Burger, Johanita; Kalemeera, Francis; Jande, Mary; Didimalang, Thatayaone; Kalungia, Aubrey Chichonyi; Matshotyana, Kidwell; Law, Michael; Malone, Brighid; Ogunleye, Olayinka; Oluka, Margaret; Paramadhas, Bene D; Rwegerera, Godfrey; Zinyowera, Sekesai; Godman, Brian

2017-04-01

The second Medicines Utilization Research in Africa (MURIA) group workshop and symposium again brought researchers together from across Africa to improve their knowledge of drug utilization (DU) methodologies and exchange ideas to further progress DU research in Africa. This built on extensive activities from the first conference including workshops and multiple publications. Anti-infectives were again the principal theme for the 2016 symposium following the workshops. This included presentations regarding strategies to improve antibiotic utilization among African countries, such as point-prevalence studies, as well as potential ways to reduce self-purchasing of antibiotics. There were also presentations on antiretrovirals including renal function and the impact of policy changes. Concerns with adherence in chronic treatments as well as drug-drug interactions and their implications were also discussed. The deliberations resulted in a number of agreed activities including joint publications before the next MURIA conference in Namibia in 2017.

STS-46 post flight press conference

NASA Astrophysics Data System (ADS)

1992-08-01

At a post flight press conference, the flight crew of the STS-46 mission (Cmdr. Loren Shriver, Pilot Andrew Allen, Mission Specialists Claude Nicollier (European Space Agency (ESA)), Marsha Ivins (Flight Engineer), Jeff Hoffman (Payload Commander), Franklin Chang-Dias, and Payload Specialist Franco Malerba (Italian Space Agency (ISA))) discussed their roles in and presented video footage, slides and still photographs of the different aspects of their mission. The primary objectives of the mission were the deployment of ESA's European Retrievable Carrier (EURECA) satellite and the joint NASA/ISA deployment and testing of the Tethered Satellite System (TSS). Secondary objectives included the IMAX Camera, the Limited Duration Space Environment Candidate Materials Exposure (LDVE), and the Pituitary Growth Hormone Cell Function (PHCF) experiments. Video footage of the EURECA and TSS deployment procedures are shown. Earth views were extensive and included Javanese volcanoes, Amazon basin forest ground fires, southern Mexico, southern Bolivian volcanoes, south-west Sudan and the Sahara Desert, and Melville Island, Australia. Questions from reporters and journalists from Johnson Space Center and Kennedy Space Center were discussed.

STS-46 Post Flight Press Conference

NASA Technical Reports Server (NTRS)

1992-01-01

At a post flight press conference, the flight crew of the STS-46 mission (Cmdr. Loren Shriver, Pilot Andrew Allen, Mission Specialists Claude Nicollier (European Space Agency (ESA)), Marsha Ivins (Flight Engineer), Jeff Hoffman (Payload Commander), Franklin Chang-Dias, and Payload Specialist Franco Malerba (Italian Space Agency (ISA))) discussed their roles in and presented video footage, slides and still photographs of the different aspects of their mission. The primary objectives of the mission were the deployment of ESA's European Retrievable Carrier (EURECA) satellite and the joint NASA/ISA deployment and testing of the Tethered Satellite System (TSS). Secondary objectives included the IMAX Camera, the Limited Duration Space Environment Candidate Materials Exposure (LDVE), and the Pituitary Growth Hormone Cell Function (PHCF) experiments. Video footage of the EURECA and TSS deployment procedures are shown. Earth views were extensive and included Javanese volcanoes, Amazon basin forest ground fires, southern Mexico, southern Bolivian volcanoes, south-west Sudan and the Sahara Desert, and Melville Island, Australia. Questions from reporters and journalists from Johnson Space Center and Kennedy Space Center were discussed.

FOREWORD: 9th International Conference on Compressors and their Systems

NASA Astrophysics Data System (ADS)

Kovacevic, Ahmed, Prof

2015-08-01

The 9th International Conference on Compressors and their Systems will be held in London from 5th - 9th September 2015, and as its Chairman, it is my pleasure to welcome you. This series of conferences started in 1999 organised by the Fluid Machinery Group of the Institution of Mechanical Engineers (IMechE) but since 2009 it has been managed by City University London in conjunction with the IMechE and the Institute of Refrigeration, both of which have been very proactive in promoting it. The Organising committee is grateful for their support and continued encouragement. This year, after rigorous reviewing, we have accepted over 80 technical papers for publication, the highest number in the conference history. On behalf of the organising committee I would like to thank the reviewers for their hard work and assistance. In addition to the main technical sessions, this year we have introduced a third day, specifically for Industry, to consider technology, business and market drivers on compressor developments. The traditional series of the short courses is this year continuing prior to the main event with the second short course/forum on Computational Fluid Dynamics in rotating positive displacement machines. I would like to extend my special thanks to our main sponsors, Holroyd PTG, Howden and Kapp Niels for their continuing support for the conference. With their generous contributions we have managed to keep the conference fees at the same level as in 2013, despite extending it to 3 days and holding it outside the University this year. The welcome reception on Sunday 6th September 2015 is dedicated to the celebration of the 20th anniversary of the Centre for Positive Displacement Compressors Technology which was formed at City University in 1995 with support from the Royal Academy of Engineering and Holroyd; its main aim being to assist British manufacturers of screw compressors. The Centre has since made a significant impact on the screw compressor world, far beyond the British Isles and continues to grow in its support for the screw machine industry. Recently renamed the Centre for Compressors Technology, its aim has been extended to help promote the development of all types of compressors and expanders. On this occasion, I must thank all those who have helped to make this event happen. Special thanks go to Louise Gordon, Emma Leaver and Sham Rane who did most of the organisation work and to all members of the organising committee and the international liaison committee. I would like to commend Dr Kristina Soldatova who joined the international liaison committee two years ago and extensively promoted the Conference in Russia which brought a large number of papers to the Conference from that part of the world. On behalf of the conference committee I wish you successful and enjoyable conference.

Update On the Status of the FLUKA Monte Carlo Transport Code*

NASA Technical Reports Server (NTRS)

Ferrari, A.; Lorenzo-Sentis, M.; Roesler, S.; Smirnov, G.; Sommerer, F.; Theis, C.; Vlachoudis, V.; Carboni, M.; Mostacci, A.; Pelliccioni, M.

2006-01-01

The FLUKA Monte Carlo transport code is a well-known simulation tool in High Energy Physics. FLUKA is a dynamic tool in the sense that it is being continually updated and improved by the authors. We review the progress achieved since the last CHEP Conference on the physics models, some technical improvements to the code and some recent applications. From the point of view of the physics, improvements have been made with the extension of PEANUT to higher energies for p, n, pi, pbar/nbar and for nbars down to the lowest energies, the addition of the online capability to evolve radioactive products and get subsequent dose rates, upgrading of the treatment of EM interactions with the elimination of the need to separately prepare preprocessed files. A new coherent photon scattering model, an updated treatment of the photo-electric effect, an improved pair production model, new photon cross sections from the LLNL Cullen database have been implemented. In the field of nucleus-- nucleus interactions the electromagnetic dissociation of heavy ions has been added along with the extension of the interaction models for some nuclide pairs to energies below 100 MeV/A using the BME approach, as well as the development of an improved QMD model for intermediate energies. Both DPMJET 2.53 and 3 remain available along with rQMD 2.4 for heavy ion interactions above 100 MeV/A. Technical improvements include the ability to use parentheses in setting up the combinatorial geometry, the introduction of pre-processor directives in the input stream. a new random number generator with full 64 bit randomness, new routines for mathematical special functions (adapted from SLATEC). Finally, work is progressing on the deployment of a user-friendly GUI input interface as well as a CAD-like geometry creation and visualization tool. On the application front, FLUKA has been used to extensively evaluate the potential space radiation effects on astronauts for future deep space missions, the activation dose for beam target areas, dose calculations for radiation therapy as well as being adapted for use in the simulation of events in the ALICE detector at the LHC.

Double- and multi-carbapenemase-producers: the excessively armored bacilli of the current decade.

PubMed

Meletis, G; Chatzidimitriou, D; Malisiovas, N

2015-08-01

Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative nosocomial pathogens commonly carry one carbapenemase gene conferring resistance to carbapenems and other beta-lactam antibiotics. However, increasing reports show that double-carbapenemase-producing (DCP) and even multi-carbapenemase-producing (MCP) bacteria are emerging in some parts of the world, diminishing further, in some cases, the already limited treatment options. In the present review, the up-to-date reports of DCP and MCP isolates are summarized and concerns regarding their emergence are discussed.

[The League of Nations Health Organization and the rise of Latin American participation, 1920-40].

PubMed

Weindling, Paul

2006-01-01

The League of Nations Health Organization collaborated with Latin American specialists in public health and infectious diseases from the early 1920s to the outbreak of the Second World War. The League developed studies of infant health and nutrition, and leprosy. The approach was expert-oriented, and designed to develop public health on a scientific basis. There were conferences, tours and reports in Latin America. This paper demonstrates that the Latin American collaboration with the Health Organization was extensive and multi-faceted.

Electron Cloud Effects in Accelerators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Furman, M.A.

Abstract We present a brief summary of various aspects of the electron-cloud effect (ECE) in accelerators. For further details, the reader is encouraged to refer to the proceedings of many prior workshops, either dedicated to EC or with significant EC contents, including the entire ?ECLOUD? series [1?22]. In addition, the proceedings of the various flavors of Particle Accelerator Conferences [23] contain a large number of EC-related publications. The ICFA Beam Dynamics Newsletter series [24] contains one dedicated issue, and several occasional articles, on EC. An extensive reference database is the LHC website on EC [25].

Proceedings of the Annual Meeting of the Eastern Snow Conference (47th) Held in Bangor, Maine on 7-8 June 1990

DTIC Science & Technology

1990-06-01

western U.S. Ten additional windows contain basin boundary data sets to map snow cover for the Upper Midwest , the Great Lakes, New England, and... Midwest and in the East. The User’s Guide gives the data format. 4.3.2 Satellite Areal Extent of Snow Cover by Basin/Zone (MCI/AFOS-ASCII) Alphanumeric...acres) of lake shore land in the snowbelt and this perennial vine is susceptible to winter cold damage. County extension agents indicated that winter

IRONSIDES: DNS With No Single Packet Denial of Service or Remote Code Execution Vulnerabilities

DTIC Science & Technology

2012-02-27

Caching DNSSEC TSIG 1Pv6 Wildcard S fi.. In terface y y Y * N __ mo e ---- o •• vare y y y N NN y m progress y y y NY N Web, Y command...Proceedings of the 2007 IEEE Aerospace Conference. [6) C. Heitmeyer, M . Archer, E. Leonard and J. Mclean, "Applying formal methods to a certifiably secure...2003). [1 5] DNSSEC-The DNS Security Extensions, http:// http://www.dnssec.net/ (16] S . Conchon, E. Contcjean and J. Kanig, "Ergo : A theorem prover

Preliminary Reports, Memoranda and Technical Notes of the Materials Research Council Summer Conference, La Jolla, CA

DTIC Science & Technology

1975-07-01

1298 (1974); T. Wei, S. Etemad, A. F. Garito and A. J. Heeger, Phys. Lett. 4_5a 269 (1973). G. A. Vhomas, et. al .. Solid State Comm. 0£, 000...C. Beer, Eds. (Academic Press, New York 1975) Vol. 11 (to be published). H. Fetterman et al ., IEEE Trans. MTT-22, 1013 (1974) 8. A. H. Silver...increasing temperature over extensive ranges. Such measure- ments were reported by Johnston et al .?1 for the fast ionic conductor RbAgJ,. Thermal

Proceedings of the 1989 Structural Integrity Program Conference Held in San Antonio, Texas on 5-7 Dec 1989

DTIC Science & Technology

1990-04-01

selected for this study because of the availability of MSD crackgrowth data pertinent to the type of situation for which the proof test had been proposed...proof and maximum service pressures. A range of proof pressure was studied , not only for the effect on post-test safe crack growth interval, but also...to investigate the potential for stable crack extension during the test itself. 30 The study author recommended 1.5P as the optimum proof pressure, the

Trends in Higher Education in the United States. No. 2. Students in the 70's. A Review of Recent Literature. A Report to the Commission on the Future, the Lutheran Educational Conference of North America.

ERIC Educational Resources Information Center

Pfnister, Allan O.

Contemporary American college students are compared with students of the 1960s, whose actions have become points of reference for discussions of the pre-1960s and post-1960s. Longitudinal studies are reviewed that indicate the gap within the generation of young people in 1969 was greater than the gap between the generations. The campus was…

KSC-00pp1576

NASA Image and Video Library

2000-09-21

This new specially equipped vehicle serves as a mobile command center for emergency preparedness staff and other support personnel when needed at KSC or Cape Canaveral Air Force Station. It features a conference room, computer work stations, mobile telephones and a fax machine. It also can generate power with its onboard generator. Besides being ready to respond in case of emergencies during launches, the vehicle must be ready to help address fires, security threats, chemical spills, terrorist attaches, weather damage or other critical situations that might face KSC or CCAFS

KSC00pp1576

NASA Image and Video Library

2000-09-21

This new specially equipped vehicle serves as a mobile command center for emergency preparedness staff and other support personnel when needed at KSC or Cape Canaveral Air Force Station. It features a conference room, computer work stations, mobile telephones and a fax machine. It also can generate power with its onboard generator. Besides being ready to respond in case of emergencies during launches, the vehicle must be ready to help address fires, security threats, chemical spills, terrorist attaches, weather damage or other critical situations that might face KSC or CCAFS

53rd Annual Fuze Conference - Next Generation Fuzing - Maximum Advantage for the Warfighter

DTIC Science & Technology

2009-05-21

Time Engineering AB 3:00 pm BREAK 3:20 pm Advances In Thermal Batteries For Fuzing David E. Harney, Advanced Thermal Batteries , Inc...Currently teaming and collaborating with Advanced Thermal Batteries • and Omnitek Partners to develop an improved thermal battery. • Current

Communicative Competence, 1966-1996.

ERIC Educational Resources Information Center

Cazden, Courtney B.

The evolution of the concept of communicative competence (CC) in language learning and teaching is traced since 1966, when D. H. Hymes first discussed it publicly. His concept of CC had its theoretical origins in the convergence of transformational generative grammar and the ethnography of communication, and was first discussed at a conference on…

DCIs, SEPs, and CCs, Oh My! Understanding the Three Dimensions of the NGSS

ERIC Educational Resources Information Center

Duncan, Ravit Golan; Cavera, Veronica L.

2015-01-01

The "Next Generation Science Standards'" three dimensions--disciplinary core ideas (DCIs), science and engineering practices (SEPs), and crosscutting concepts (CCs)--were headliners at NSTA's national conference in Chicago and featured in many of the organization's other professional-development efforts this year (NGSS Lead States 2013).…

What's New in the Library Automation Arena?

ERIC Educational Resources Information Center

Breeding, Marshall

1998-01-01

Reviews trends in library automation based on vendors at the 1998 American Library Association Annual Conference. Discusses the major industry trend, a move from host-based computer systems to the new generation of client/server, object-oriented, open systems-based automation. Includes a summary of developments for 26 vendors. (LRW)

Telecommunications Policy Research Conference. Telecommunications and Growth in Developing Countries Section. Papers.

ERIC Educational Resources Information Center

Telecommunications Policy Research Conference, Inc., Washington, DC.

Four papers consider the growth of telecommunications in developing countries: (1) "Telecommunications Investment in Developing Countries and the Generation of Foreign Exchange: The Impact of Electronic Funds Transfer" (Heather E. Hudson and Lynn C. York); (2) "The Effect of Information Sector Growth on Telecommunications…

Political Responses to Aging.

ERIC Educational Resources Information Center

Thorson, James A., Ed.; Payne, Barbara P., Ed.

The proceedings of the First Annual Georgia Conference on Aging contains five papers, reports from discussion groups, and transcripts of a panel discussion. The focus was on the encouragement of self-advocacy and the identification of achievable goals among older adults in order to generate some of the basic political changes that will improve the…

Automating Document Delivery: A Conference Report.

ERIC Educational Resources Information Center

Ensor, Pat

1992-01-01

Describes presentations made at a forum on automation, interlibrary loan (ILL), and document delivery sponsored by the Houston Area Library Consortium. Highlights include access versus ownership; software for ILL; fee-based services; automated management systems for ILL; and electronic mail and online systems for end-user-generated ILL requests.…

Helicopter Acoustics, part 2. [conferences

NASA Technical Reports Server (NTRS)

1978-01-01

Exterior and interior helicopter noise problems are addressed from the physics and engineering as well as the human factors point of view. Noise regulation concepts, human factors and criteria, rotor noise generation and control, design, operations and testing for noise control, helicopter noise prediction, and research tools and measurements are covered.

Why We (AAHPERD Leaders) Do What We Do

ERIC Educational Resources Information Center

Strand, Bradford; Worrell, Vicki; Wiedow, Gale

2013-01-01

At a recent American Alliance for Health, Physical Education, Recreation and Dance (AAHPERD) Leadership Development Conference, presidents-elect representing state, district, and national AAHPERD associations were asked to describe in one sentence why they do what they do. The 67 responses were entered into wordle.net that generated the 20-item…

Lifelong Learning Research Conference Proceedings (7th, College Park, Maryland, February 21-22, 1985).

ERIC Educational Resources Information Center

Rivera, William M., Comp.; Walker, Sharon M., Comp.

The 48 papers in this proceedings focus on aspects of non-formal adult education including international comparative adult education. The papers are: "Lifelong Learning in Perspective" (Knox); "Women in their Thirties: The In-Between Generation" (Caffarella, Freeman); "Development in Women: An Analysis of the…

The Education of Young Children: At the Crossroads?

ERIC Educational Resources Information Center

Heath, Douglas H.

1969-01-01

Discusses gap which has developed because educators emphasize academic excellence while adolescents are characterized by an interest in human values and growing emotional isolation. Suggestions for meeting the needs of this generation are offered. (Address presented at the 1969 Conference of the National Association for The Education of Young…

Fully device-independent conference key agreement

NASA Astrophysics Data System (ADS)

Ribeiro, Jérémy; Murta, Gláucia; Wehner, Stephanie

2018-02-01

We present a security analysis of conference key agreement (CKA) in the most adversarial model of device independence (DI). Our protocol can be implemented by any experimental setup that is capable of performing Bell tests [specifically, the Mermin-Ardehali-Belinskii-Klyshko (MABK) inequality], and security can in principle be obtained for any violation of the MABK inequality that detects genuine multipartite entanglement among the N parties involved in the protocol. As our main tool, we derive a direct physical connection between the N -partite MABK inequality and the Clauser-Horne-Shimony-Holt (CHSH) inequality, showing that certain violations of the MABK inequality correspond to a violation of the CHSH inequality between one of the parties and the other N -1 . We compare the asymptotic key rate for device-independent conference key agreement (DICKA) to the case where the parties use N -1 device-independent quantum key distribution protocols in order to generate a common key. We show that for some regime of noise the DICKA protocol leads to better rates.

Conference Grant Proposal for ICOPS 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Safronova, Alla

ICOPS (International Conference on Plasma Science) is an internationally renowned, well-attended annual conference that involves topics of direct interest to the Office of Fusion Energy Sciences of Department of Energy. In particular, ICOPS 2016 emphasized both the traditional areas of plasma science and the new areas of growth that include but are not limited to Fusion (Inertial, Magnetic and Alternate Concepts), Particle Acceleration with Laser and Beams, High Energy Density Matter, Laser Produced Plasma, Fast Z-pinches, Computational Plasma Physics, Plasma Diagnostics, and such frontiers as studying Warm Dense Matter using the X-ray free electron lasers. The travel support of themore » students at ICOPS comes usually from sponsor organizations. Increasing the participation of outstanding students at ICOPS 2016 who are the first authors of the abstracts and are selected to receive the travel support based on the scientific merit of the submitted abstracts is crucial for the creation of the new generation of the plasma physicists.« less

(Tribology conferences and forums)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yust, C.S.

The principal meeting attended during this trip was the Japan International Tribology Conference Nagoya 1990. The conference encompassed a wide range of topics, including the tribology of ceramics, the tribology in high-performance automobiles, and many aspects of lubrication technology. Associated forums were also held on the tribology of advanced ceramics, on solid lubrication, and on automotive lubricants. Presentations made during the latter forum discussed anticipated trends in engine development and anticipated improvements in lubricants required for the next generation of engines. In addition to meetings, site visits were made to five industrial organizations to discuss ceramic tribology. Nippon Steel Corporationmore » and Toshiba Corporation are both very active in the ceramic area, Nippon Steel from their interest in research on new materials and Toshiba from both an interest in new materials and in support of their work in electronic devices. Two engine manufacturers were also visited, Toyota Motor Corporation, and Nissan Motor Co., Ltd. These companies were somewhat reserved in their discussion of progress in the utilization of ceramics in automobile engines.« less

Tethers in Space

NASA Astrophysics Data System (ADS)

Johnson, Les; Bilén, Sven G.; Gilchrist, Brian E.; Krause, Linda Habash

2017-09-01

This Special Section of Acta Astronautica contains several peer-reviewed papers selected from among those presented at the Fifth International Conference on Tethers in Space (TiS2016). After a hiatus of 21 years since the last Conference on Tethers in Space, TiS2016 brought together experts, practitioners, and other interested in space tethers and related fields. TiS2016 was held May 24-26, 2016 at The University of Michigan in Ann Arbor, Michigan, U.S.A. Leveraging the hard work of a great many volunteers, the conference co-chairs Prof. Brian Gilchrist and Prof. Sven Bilén welcomed an international contingent with authors from the U.S., Canada, Japan, Spain, China, Finland, Estonia, and Italy. The community provided updates on what has transpired since their last gathering by providing lessons learned; describing new technologies and subsystems; and proposing new tether missions and applications. Papers overviewed de-orbit systems, power generation, orbital maneuvering, momentum capture, debris removal, space tugs, space elevators, collision avoidance, and tether dynamics, among others.

Quantum spaces, central extensions of Lie groups and related quantum field theories

NASA Astrophysics Data System (ADS)

Poulain, Timothé; Wallet, Jean-Christophe

2018-02-01

Quantum spaces with su(2) noncommutativity can be modelled by using a family of SO(3)-equivariant differential *-representations. The quantization maps are determined from the combination of the Wigner theorem for SU(2) with the polar decomposition of the quantized plane waves. A tracial star-product, equivalent to the Kontsevich product for the Poisson manifold dual to su(2) is obtained from a subfamily of differential *-representations. Noncommutative (scalar) field theories free from UV/IR mixing and whose commutative limit coincides with the usual ϕ 4 theory on ℛ3 are presented. A generalization of the construction to semi-simple possibly non simply connected Lie groups based on their central extensions by suitable abelian Lie groups is discussed. Based on a talk presented by Poulain T at the XXVth International Conference on Integrable Systems and Quantum symmetries (ISQS-25), Prague, June 6-10 2017.

The artist's advantage: Better integration of object information across eye movements

PubMed Central

Perdreau, Florian; Cavanagh, Patrick

2013-01-01

Over their careers, figurative artists spend thousands of hours analyzing objects and scene layout. We examined what impact this extensive training has on the ability to encode complex scenes, comparing participants with a wide range of training and drawing skills on a possible versus impossible objects task. We used a gaze-contingent display to control the amount of information the participants could sample on each fixation either from central or peripheral visual field. Test objects were displayed and participants reported, as quickly as possible, whether the object was structurally possible or not. Our results show that when viewing the image through a small central window, performance improved with the years of training, and to a lesser extent with the level of skill. This suggests that the extensive training itself confers an advantage for integrating object structure into more robust object descriptions. PMID:24349697

Book Review: Book review

NASA Astrophysics Data System (ADS)

Tweed, Fiona S.

2017-08-01

This special edition of Zeitschrift für Geomorphologie (ZfG) is based on presentations given at a conference entitled 'Hydrological Extreme Events in Historic and Prehistoric Times' which took place in Bonn in June 2014. The volume consists of an editorial introduction and nine research papers reflecting a range of approaches to understanding past events, including modelling, analysis of historical data and studies that focus on a consistent approach to collection and analysis of data from different areas. The HEX project, which generated the conference in Bonn, adopted a multidisciplinary approach and this is reflected in the collection of papers, which emphasise the importance of combining a range of approaches and analyses as tools for decoding both landscapes and processes.

Designing an Easy-to-use Executive Conference Room Control System

NASA Astrophysics Data System (ADS)

Back, Maribeth; Golovchinsky, Gene; Qvarfordt, Pernilla; van Melle, William; Boreczky, John; Dunnigan, Tony; Carter, Scott

The Usable Smart Environment project (USE) aims at designing easy-to-use, highly functional, next-generation conference rooms. Our first design prototype focuses on creating a “no wizards” room for an American executive; that is, a room the executive could walk into and use by himself, without help from a technologist. A key idea in the USE framework is that customization is one of the best ways to create a smooth user experience. As the system needs to fit both with the personal leadership style of the executive and the corporation’s meeting culture, we began the design process by exploring the work flow in and around meetings attended by the executive.

Spectral Line Shapes. Proceedings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zoppi, M.; Ulivi, L.

1997-02-01

These proceedings represent papers presented at the 13th International Conference on Spectral Line Shapes which was held in Firenze,Italy from June 16-21, 1996. The topics covered a wide range of subjects emphasizing the physical processes associated with the formation of line profiles: high and low density plasma; atoms and molecules in strong laser fields, Dopple{minus}free and ultra{minus}fine spectroscopy; the line shapes generated by the interaction of neutrals, atoms and molecules, where the relavant quantities are single particle properties, and the interaction{minus}induced spectroscopy. There were 131 papers presented at the conference, out of these, 6 have been abstracted for the Energymore » Science and Technology database.(AIP)« less

New Advances and Challenges of Targeting Cancer Stem Cells.

PubMed

Dashzeveg, Nurmaa K; Taftaf, Rokana; Ramos, Erika K; Torre-Healy, Luke; Chumakova, Anastasia; Silver, Daniel J; Alban, Tyler J; Sinyuk, Maksim; Thiagarajan, Praveena S; Jarrar, Awad M; Turaga, Soumya M; Saygin, Caner; Mulkearns-Hubert, Erin; Hitomi, Masahiro; Rich, Jeremy N; Gerson, Stanton L; Lathia, Justin D; Liu, Huiping

2017-10-01

The second International Cancer Stem Cell Conference in Cleveland, Ohio, on September 20-23, 2016, convened 330 attendees from academic, industrial, and clinical organizations. It featured a debate on the concepts and challenges of the cancer stem cells (CSC) as well as CSC-centered scientific sessions on clinical trials, genetics and epigenetics, tumor microenvironment, immune suppression, metastasis, therapeutic resistance, and emerging novel concepts. The conference hosted 35 renowned speakers, 100 posters, 20 short talks, and a preconference workshop. The reported advances of CSC research and therapies fostered new collaborations across national and international borders, and inspired the next generation's young scientists. Cancer Res; 77(19); 5222-7. ©2017 AACR . ©2017 American Association for Cancer Research.

Strategic placement of stereogenic centers in molecular materials for second harmonic generation.

PubMed

Gangopadhyay, P; Rao, D Narayana; Agranat, Israel; Radhakrishnan, T P

2002-01-01

Basic aspects of the nonlinear optical phenomenon of second harmonic generation (SHG) and the assembly of molecular materials for SHG are reviewed. Extensive use of chirality as a convenient tool to generate noncentrosymmetricity in molecular lattices, an essential requirement for the development of quadratic nonlinear optical materials, is noted. An overview of our investigations of chiral diaminodicyanoquinodimethanes is presented, which provides insight into a systematic approach to the effective deployment of chirality to achieve optimal molecular orientations for enhanced solid state SHG. Extension of these ideas to the realization of strong SHG in materials based on helical superstructures is outlined.

PREFACE: 17th Pan-American Synchrotron Radiation Instrumentation Conference SRI2013

NASA Astrophysics Data System (ADS)

Williams, Gwyn P.; Revesz, Peter; Arp, Uwe

2014-03-01

These proceedings are a collection of the articles presented at the seventeenth Pan-American Synchrotron Radiation Instrumentation Conference SRI2013, held on the campus of the National Institute of Standards and Technology (NIST), located in Gaithersburg, Maryland, United States of America, 19-21 June, 2013. SRI2013 was jointly hosted by the Cornell University Cornell High Energy Synchrotron Source (CHESS), the Thomas Jefferson National Accelerator Facility (Jefferson Lab), and the Synchrotron Ultraviolet Radiation Facility (SURF III) at NIST. This meeting's focus was clearly on instrumentation, thus fulfilling the intent of this SRI meeting series, which was initiated at NIST, then the National Bureau of Standards (NBS), in 1979. SRI2013 hosted more than 150 delegates, despite the new US governmental travel restrictions. This proceedings series aims to be an essential reference work for practitioners in the field. It primarily documents the evolution and development of techniques, but also recent scientific advances, that were presented during the two and a half days of the conference. We are extremely thankful to all the authors who contributed to making these proceedings a volume of reference as well as to the reviewers for their careful reading and constructive recommendations for improving the articles. Great thanks go to Robert Dragoset at NIST, for creating and maintaining the conference website and generating the conference logo. We are also thankful for the excellent support we received from the Conference Program at NIST, especially Kathy Kilmer and Angela Ellis. And we would like to dedicate these proceedings to the memory of Kathy Kilmer, who passed away on 15 October, 2013. NIST will not be the same without her. The Co-Editors: Uwe Arp (SURF/NIST) Peter Reversz (CHESS) Gwyn P Williams (Jefferson Lab)

FY 2014 Continuation of Solicitation for the Office of Science Financial Assistance Program

DOE Office of Scientific and Technical Information (OSTI.GOV)

Saundry, Peter

2014-04-01

On January 28-30, 2014, the National Council for Science and the Environment (NCSE) hosted its 14th National Confrerence and Global Forum on Science, Policy and the Environment: Building Climate Solutions. The conference was held at the Hyatt Regency Crystal City near the Washington, DC National Airport. The conference engaged over 1,100 key individuals from a variety of fields, including natural and social sciences, humanities and engineering and government and policy, as well as business and civil society. They developed actionable partnerships, strategies and tactics that advanced solutions minimizing the impacts of anthropogenic climate change. The conference was organized around themore » two major areas where climate actions are necessary: [1] The Built Environment; and, [2] Agriculture and Natural Resources. This “multi-sector approach” of the conference enables participants to work across traditional boundaries of discipline, science, policy and application by engaging a diverse team of scientists, public- and private-sector program managers, and policy-makers. The confernce was two and a half days long. During this time, over 200 speakers presented in 8 keynote addresses, 7 plenary roundtable discussions, 30 symposia and 23 workshops. The goal of the workshops was to generate additional action through development of improved strategies, tools, and partnerships. During the workshops, participants developed actionable outcomes, committed to further collaboration and implementation, and outlined follow-up activities for post-conference. A list of recommendations from the workshop follows this summary. NCSE’s annual conference has become a signature event for the organization, recognized for its notable presenters, innovative programming, and outcome-oriented approach. Each year, over 1,100 participants attend the event, representing federal agencies, higher education institutions, state and local governments, non-governmental and civic organizations, businesses, and international entities.« less

Generation of a Listeria vaccine strain by enhanced Caspase-1 activation

PubMed Central

Warren, Sarah E.; Duong, Hien; Mao, Dat Phat; Armstrong, Abraham; Rajan, Jayant; Miao, Edward A.; Aderem, Alan

2012-01-01

The immunostimulatory properties conferred by vaccine adjuvants require Caspase-1 for processing of IL-1β and IL-18. Caspase-1 is activated in response to a breach of the cytosolic compartment by microbes and the process is initiated by intracellular pattern recognition receptors within inflammasomes. Listeria monocytogenes is detected in the cytosol by the NLRC4, NLRP3 and AIM2 inflammasomes. NLRC4 is activated by flagellin, and L. monocytogenes evades this detector by repressing flagellin expression. We generated an L. monocytogenes strain that was forced to express flagellin in the host cell cytosol. This strain hyperactivated Caspase-1 and was preferentially cleared via NLRC4 detection in an IL-1β/IL-18 independent manner. We also created a strain of L. monocytogenes with forced expression of another NLRC4 agonist, PrgJ from the Type III secretion system of S. typhimurium. Forced expression of flagellin or PrgJ resulted in attenuation, yet both strains conferred protective immunity in mice against lethal challenge with L. monocytogenes. This work is the first demonstration of specific targeting of the Caspase-1 activation pathway to generate a safe and potent L. monocytogenes based vaccine. Moreover, the attenuated strains with embedded flagellin or PrgJ adjuvants, represent attractive vectors for vaccines aimed at eliciting T cell responses. PMID:21538346

The European SL-9/JUPITER Workshop

NASA Astrophysics Data System (ADS)

1995-02-01

During the past six months, many astronomers - observational as well theoretical - have been busy interpreting the many data taken during the impacts and thereafter. This is a very labour-intensive task and although the first conclusions have begun to emerge, it has also become obvious that extensive consultations between the various groups are necessary before it will be possible to understand the very complex processes during the impacts and thereafter. In order to further the interaction among the involved scientists, it has been decided to hold a three-day "European SL-9/Jupiter Workshop" at the Headquarters of the European Southern Observatory. More than 100 astronomers will meet on February 13-15, 1995, and close to 100 reports will be delivered on this occasion. Although most come from European countries, the major groups on other continents are also well represented. This meeting will give the participants the opportunity to exchange information about their individual programmes and will serve to establish future collaborative efforts. SL-9/JUPITER PRESS CONFERENCE In this connection, ESO is pleased to invite the media to a Press Conference: Wednesday, February 15, 1995, 17:30 CET ESO Headquarters, Karl-Schwarzschild-Strasse 2, D-85748 Garching, Germany This conference will be held at the end of the Workshop and will provide a thorough overview of the latest results, as presented during the meeting. Media representatives who are interested in participating in this Press Conference are requested to register with the ESO Information Service (Mrs. E. Völk, Tel.: +49-89-32006276; Fax: +49-89-3202362), at the latest on Friday, February 10, 1995. ESO Press Information is made available on the World-Wide Web (URL: http://www.hq.eso.org/) and on CompuServe (space science and astronomy area, GO SPACE).

What Is the Best Way to Measure Surgical Quality? Comparing the American College of Surgeons National Surgical Quality Improvement Program versus Traditional Morbidity and Mortality Conferences.

PubMed

Zhang, Jacques X; Song, Diana; Bedford, Julie; Bucevska, Marija; Courtemanche, Douglas J; Arneja, Jugpal S

2016-04-01

Morbidity and mortality conferences have played a traditional role in tracking complications. Recently, the American College of Surgeons National Surgical Quality Improvement Program Pediatrics (ACS NSQIP-P) has gained popularity as a risk-adjusted means of addressing quality assurance. The purpose of this article is to report an analysis of the two methodologies used within pediatric plastic surgery to determine the best way to manage quality. ACS NSQIP-P and morbidity and mortality data were extracted for 2012 and 2013 at a quaternary care institution. Overall complication rates were compared statistically, segregated by type and severity, followed by a subset comparison of ACS NSQIP-P-eligible cases only. Concordance and discordance rates between the two methodologies were determined. One thousand two hundred sixty-one operations were performed in the study period. Only 51.4 percent of cases were ACS NSQIP-P eligible. The overall complication rates of ACS NSQIP-P (6.62 percent) and morbidity and mortality conferences (6.11 percent) were similar (p = 0.662). Comparing for only ACS NSQIP-P-eligible cases also yielded a similar rate (6.62 percent versus 5.71 percent; p = 0.503). Although different complications are tracked, the concordance rate for morbidity and mortality and ACS NSQIP-P was 35.1 percent and 32.5 percent, respectively. The ACS NSQIP-P database is able to accurately track complication rates similarly to morbidity and mortality conferences, although it samples only half of all procedures. Although both systems offer value, limitations exist, such as differences in definitions and purpose. Because of the rigor of the ACS NSQIP-P, we recommend that it be expanded to include currently excluded cases and an extension of the study interval.

Genome-wide analysis of heat shock proteins in C4 model, foxtail millet identifies potential candidates for crop improvement under abiotic stress.

PubMed

Singh, Roshan Kumar; Jaishankar, Jananee; Muthamilarasan, Mehanathan; Shweta, Shweta; Dangi, Anand; Prasad, Manoj

2016-09-02

Heat shock proteins (HSPs) perform significant roles in conferring abiotic stress tolerance to crop plants. In view of this, HSPs and their encoding genes were extensively characterized in several plant species; however, understanding their structure, organization, evolution and expression profiling in a naturally stress tolerant crop is necessary to delineate their precise roles in stress-responsive molecular machinery. In this context, the present study has been performed in C4 panicoid model, foxtail millet, which resulted in identification of 20, 9, 27, 20 and 37 genes belonging to SiHSP100, SiHSP90, SiHSP70, SiHSP60 and SisHSP families, respectively. Comprehensive in silico characterization of these genes followed by their expression profiling in response to dehydration, heat, salinity and cold stresses in foxtail millet cultivars contrastingly differing in stress tolerance revealed significant upregulation of several genes in tolerant cultivar. SisHSP-27 showed substantial higher expression in response to heat stress in tolerant cultivar, and its over-expression in yeast system conferred tolerance to several abiotic stresses. Methylation analysis of SiHSP genes suggested that, in susceptible cultivar, higher levels of methylation might be the reason for reduced expression of these genes during stress. Altogether, the study provides novel clues on the role of HSPs in conferring stress tolerance.

Mutation of environmental mycobacteria to resist silver nanoparticles also confers resistance to a common antibiotic.

PubMed

Larimer, Curtis; Islam, Mohammad Shyful; Ojha, Anil; Nettleship, Ian

2014-08-01

Non-tuberculous mycobacteria are a threat to human health, gaining entry to the body through contaminated water systems, where they form persistent biofilms despite extensive attempts at disinfection. Silver is a natural antibacterial agent and in nanoparticle form activity is increased by a high surface area. Silver nanoparticles (AgNPs) have been used as alternative disinfectants in circulating water systems, washing machines and even clothing. However, nanoparticles, like any other antibiotic that has a pervasive durable presence, carry the risk of creating a resistant population. In this study Mycobacterium smegmatis strain mc(2)155 was cultured in AgNP enriched agar such that only a small population survived. Surviving cultures were isolated and re-exposed to AgNPs and AgNO3 and resistance to silver was compared to a negative control. After only a single exposure, mutant M. smegmatis populations were resistant to AgNPs and AgNO3. Further, the silver resistant mutants were exposed to antibiotics to determine if general resistance had been conferred. The minimum inhibitory concentration of isoniazid was four times higher for silver resistant mutants than for strain mc(2)155. However, core resistance was not conferred to other toxic metal ions. The mutants had lower resistance to CuSO4 and ZnSO4 than the mc(2)155 strain.

Highlights from Faraday Discussion 172: Carbon in Electrochemistry, Sheffield, UK, July 2014

DOE PAGES

Dyatkin, Boris; Ash, Philip A.; Sharma, Surbhi

2015-01-12

Faraday Discussions have been very true to their name, focusing genuinely on healthy, in-depth, and fruitful discussions rather than just serving as a platform for one to one researcher interaction and collaboration. So the first experience of a Faraday Discussion is always an eye-opener about how lively conference discussions can become. The format follows that presenters submit full papers a few months in advance which are lightly reviewed before all the papers are circulated to each of the registered participants. Participants arrive at the conference prepared with their queries and arguments after having read the circulated manuscripts. At the conferencemore » the authors present their work for five minutes each followed by extensive discussion of 20–25 minutes, which is practically a ‘‘live peer-review’’. Moreover, this experience of a discussion-cum-peer review with participants ranging for PhD students to experts in the relevant field is both a daunting and a very enriching experience at the same time. This has been the trend since the first Faraday Discussions held in London in 1907 in London which debated ‘‘osmotic pressure’’,1 and this format clearly sets it apart from any other conference to date. All discussions form part of the peer review process and are sequentially recorded and published with the accepted manuscripts.« less

STANLEY (Sandia Text ANaLysis Extensible librarY) Ver. 1.1

DOE Office of Scientific and Technical Information (OSTI.GOV)

BENZ, ZACHARY; APODACA, VINCENT; BASILICO, JUSTIN

2009-11-10

Reusable, extensible text analysis library. This library forms the basis for the automated generation of cognitive models from text for Sandia's Cognition program. It also is the basis for the suite of underlying, related applications.

Advanced power assessment for Czech lignite, Task 3.6, Part 2. The 2nd international conference on energy and environment: Transitions in East Central Europe

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sondreal, E.A.; Mann, M.D.; Weber, G.W.

1995-12-01

On November 1-5, 1994, the Energy & Environmental Research Center (EERC) and Power Research Institute of Prague cosponsored their second conference since 1991 in the Czech Republic, entitled ``Energy and Environment: Transitions in East Central Europe.`` This conference was a continuation of the EERC`s joint commitment, initiated in 1190, to facilitate solutions to short- and long-term energy and environmental problems in East Central Europe. Production of energy from coal in an environmentally acceptable manner is a critical issue facing East Central Europe, because the region continues to rely on coal as its primary energy source. The goal of the conferencemore » was to develop partnerships between industry, government, and the research community in East Central Europe and the United States to solve energy and environmental issues in a manner that fosters economic development. Among the topics addressed at the conference were: conventional and advanced energy generation systems; economic operation of energy systems; air pollution controls; power system retrofitting and repowering, financing options; regulatory issues; energy resource options; waste utilization and disposal; and long-range environmental issues. Selected papers in the proceedings have been processed separately for inclusion in the Energy Science and Technology database.« less

Meeting report VLPNPV: Sessions 1 and 2: Plenary.

PubMed

Sainsbury, Frank

2014-01-01

Following the highly successful inaugural meeting in 2012, the second installment of Virus-Like Particles and Nano-Particle Vaccines (VLPNPV), proved to be a worthy follow-up in an outstanding conference series. VLPNPV is a forum for academics and industry to address one of the major areas of need in biomedical sciences, the development of novel prophylactic and therapeutic vaccines. The conference was opened by Professor Marianne Manchester of the University of California, San Diego who pointed to the significance of the site chosen for the conference, the Salk Institute. Founded by Jonas Salk, the Salk Institute for Biological Studies is a non-profit, independent research institute with focuses in molecular biology and genetics, neurosciences, and plant biology. This diversity in research themes reflects the wishes of the institute's founder who saw value in using interdisciplinary approaches to understanding the basic principles in life, aimed at generating new therapies and treatments for human disease. Likewise, interdisciplinarity was reflected in the main themes of the meeting, which also highlight some of the potential advantages of virus-like particle (VLP) and nanoparticle vaccines, including novel formulations/adjuvanting effects, structurally accurate/designed antigens, production systems and capacity, and tailoring the immune response. These themes were covered by the 2 plenary sessions that opened the conference and are described in this report.

Co-Expression of Monodehydroascorbate Reductase and Dehydroascorbate Reductase from Brassica rapa Effectively Confers Tolerance to Freezing-Induced Oxidative Stress

PubMed Central

Shin, Sun-Young; Kim, Myung-Hee; Kim, Yul-Ho; Park, Hyang-Mi; Yoon, Ho-Sung

2013-01-01

Plants are exposed to various environmental stresses and have therefore developed antioxidant enzymes and molecules to protect their cellular components against toxicity derived from reactive oxygen species (ROS). Ascorbate is a very important antioxidant molecule in plants, and monodehydroascorbate reductase (MDHAR; EC 1.6.5.4) and dehydroascorbate reductase (DHAR; EC 1.8.5.1) are essential to regeneration of ascorbate for maintenance of ROS scavenging ability. The MDHAR and DHAR genes from Brassica rapa were cloned, transgenic plants overexpressing either BrMDHAR and BrDHAR were established, and then, each transgenic plant was hybridized to examine the effects of co-expression of both genes conferring tolerance to freezing. Transgenic plants co-overexpressing BrMDHAR and BrDHAR showed activated expression of relative antioxidant enzymes, and enhanced levels of glutathione and phenolics under freezing condition. Then, these alteration caused by co-expression led to alleviated redox status and lipid peroxidation and consequently conferred improved tolerance against severe freezing stress compared to transgenic plants overexpressing single gene. The results of this study suggested that although each expression of BrMDHAR or BrDHAR was available to according tolerance to freezing, the simultaneous expression of two genes generated synergistic effects conferring improved tolerance more effectively even severe freezing. PMID:24170089

Educating residents for managed care: report on a multidisciplinary conference.

PubMed

Hewson, M G; Fishleder, A J; Halperin, A K; Henry, C A; Isaacson, J H; Kachur, E; Tresolini, C

1998-05-01

A growing number of residency programs are preparing their graduates for the realities of managed care practice. In 1996, The Cleveland Clinic Foundation, a private, nonprofit academic medical center, hosted a two-day conference on managed care education to develop innovative instructional and evaluative approaches that, where appropriate, would build on existing expertise. The conference was attended by invited national experts who had a stake in residents' education: clinical faculty, residents, medical educators, executives of managed care organizations, and representatives of other interested organizations. Participants spent much of their time in four small break out groups, each focusing on one of the following topics that were judged particularly relevant to managed care: preventive and population-based medicine, appropriate utilization of resources, clinician-patient communication, and interdisciplinary team practice. Participants shared existing materials, discussed teaching goals and objectives, and generated ideas for teaching methods, teaching materials, and evaluative methods for their respective topics. The authors summarize the recommendations from the four groups, with an overview of the issues that emerged during the conference concerning curriculum development, integration of managed care topics into existing curricula, staging of the curriculum, experiential teaching methods, negative attitudes and resistance, evaluation of trainees and profiling, program assessment, faculty development, and cooperation between academic medical centers and managed care organizations.

The ASCI Network for SC '99: A Step on the Path to a 100 Gigabit Per Second Supercomputing Network

DOE Office of Scientific and Technical Information (OSTI.GOV)

PRATT,THOMAS J.; TARMAN,THOMAS D.; MARTINEZ,LUIS M.

2000-07-24

This document highlights the Discom{sup 2}'s Distance computing and communication team activities at the 1999 Supercomputing conference in Portland, Oregon. This conference is sponsored by the IEEE and ACM. Sandia, Lawrence Livermore and Los Alamos National laboratories have participated in this conference for eleven years. For the last four years the three laboratories have come together at the conference under the DOE's ASCI, Accelerated Strategic Computing Initiatives rubric. Communication support for the ASCI exhibit is provided by the ASCI DISCOM{sup 2} project. The DISCOM{sup 2} communication team uses this forum to demonstrate and focus communication and networking developments within themore » community. At SC 99, DISCOM built a prototype of the next generation ASCI network demonstrated remote clustering techniques, demonstrated the capabilities of the emerging Terabit Routers products, demonstrated the latest technologies for delivering visualization data to the scientific users, and demonstrated the latest in encryption methods including IP VPN technologies and ATM encryption research. The authors also coordinated the other production networking activities within the booth and between their demonstration partners on the exhibit floor. This paper documents those accomplishments, discusses the details of their implementation, and describes how these demonstrations support Sandia's overall strategies in ASCI networking.« less

Development of ultrashort x-ray/gamma-ray sources using ultrahigh power lasers (Conference Presentation)

NASA Astrophysics Data System (ADS)

Kim, Hyung Taek; Nakajima, Kazuhisa; Hojbota, Calin; Jeon, Jong Ho; Rhee, Yong-Joo; Lee, Kyung Hwan; Lee, Seong Ku; Sung, Jae Hee; Lee, Hwang Woon; Pathak, Vishwa B.; Pae, Ki Hong; Sebban, Stéphane; Tissandier, Fabien; Gautier, Julien; Ta Phuoc, Kim; Malka, Victor; Nam, Chang Hee

2017-05-01

Short-pulse x-ray/gamma-ray sources have become indispensable light sources for investigating material science, bio technology, and photo-nuclear physics. In past decades, rapid advancement of high intensity laser technology led extensive progresses in the field of radiation sources based on laser-plasma interactions - x-ray lasers, betatron radiation and Compton gamma-rays. Ever since the installation of a 100-TW laser in 2006, we have pursued the development of ultrashort x-ray/gamma-ray radiations, such as x-ray lasers, relativistic high-order harmonics, betatron radiation and all-optical Compton gamma-rays. With the construction of two PW Ti:Sapphire laser beamlines having peak powers of 1.0 PW and 1.5 PW in 2010 and 2012, respectively [1], we have investigated the generation of multi-GeV electron beams [2] and MeV betatron radiations. We plan to carry out the Compton backscattering to generate MeV gamma-rays from the interaction of a GeV electron beam and a PW laser beam. Here, we present the recent progress in the development of ultrashort x-ray/gamma-ray radiation sources based on laser plasma interactions and the plan for developing Compton gamma-ray sources driven by the PW lasers. In addition, we will present the applications of laser-plasma x-ray lasers to x-ray holography and coherent diffraction imaging. [references] 1. J. H. Sung, S. K. Lee, T. J. Yu, T. M. Jeong, and J. Lee, Opt. Lett. 35, 3021 (2010). 2. H. T. Kim, K. H. Pae, H. J. Cha, I J. Kim, T. J. Yu, J. H. Sung, S. K. Lee, T. M. Jeong, J. Lee, Phys. Rev. Lett. 111, 165002 (2013).

Intact Protein Analysis at 21 Tesla and X-Ray Crystallography Define Structural Differences in Single Amino Acid Variants of Human Mitochondrial Branched-Chain Amino Acid Aminotransferase 2 (BCAT2)

NASA Astrophysics Data System (ADS)

Anderson, Lissa C.; Håkansson, Maria; Walse, Björn; Nilsson, Carol L.

2017-09-01

Structural technologies are an essential component in the design of precision therapeutics. Precision medicine entails the development of therapeutics directed toward a designated target protein, with the goal to deliver the right drug to the right patient at the right time. In the field of oncology, protein structural variants are often associated with oncogenic potential. In a previous proteogenomic screen of patient-derived glioblastoma (GBM) tumor materials, we identified a sequence variant of human mitochondrial branched-chain amino acid aminotransferase 2 as a putative factor of resistance of GBM to standard-of-care-treatments. The enzyme generates glutamate, which is neurotoxic. To elucidate structural coordinates that may confer altered substrate binding or activity of the variant BCAT2 T186R, a 45 kDa protein, we applied combined ETD and CID top-down mass spectrometry in a LC-FT-ICR MS at 21 T, and X-Ray crystallography in the study of both the variant and non-variant intact proteins. The combined ETD/CID fragmentation pattern allowed for not only extensive sequence coverage but also confident localization of the amino acid variant to its position in the sequence. The crystallographic experiments confirmed the hypothesis generated by in silico structural homology modeling, that the Lys59 side-chain of BCAT2 may repulse the Arg186 in the variant protein (PDB code: 5MPR), leading to destabilization of the protein dimer and altered enzyme kinetics. Taken together, the MS and novel 3D structural data give us reason to further pursue BCAT2 T186R as a precision drug target in GBM. [Figure not available: see fulltext.

Accessory genes confer a high replication rate to virulent feline immunodeficiency virus.

PubMed

Troyer, Ryan M; Thompson, Jesse; Elder, John H; VandeWoude, Sue

2013-07-01

Feline immunodeficiency virus (FIV) is a lentivirus that causes AIDS in domestic cats, similar to human immunodeficiency virus (HIV)/AIDS in humans. The FIV accessory protein Vif abrogates the inhibition of infection by cat APOBEC3 restriction factors. FIV also encodes a multifunctional OrfA accessory protein that has characteristics similar to HIV Tat, Vpu, Vpr, and Nef. To examine the role of vif and orfA accessory genes in FIV replication and pathogenicity, we generated chimeras between two FIV molecular clones with divergent disease potentials: a highly pathogenic isolate that replicates rapidly in vitro and is associated with significant immunopathology in vivo, FIV-C36 (referred to here as high-virulence FIV [HV-FIV]), and a less-pathogenic strain, FIV-PPR (referred to here as low-virulence FIV [LV-FIV]). Using PCR-driven overlap extension, we produced viruses in which vif, orfA, or both genes from virulent HV-FIV replaced equivalent genes in LV-FIV. The generation of these chimeras is more straightforward in FIV than in primate lentiviruses, since FIV accessory gene open reading frames have very little overlap with other genes. All three chimeric viruses exhibited increased replication kinetics in vitro compared to the replication kinetics of LV-FIV. Chimeras containing HV-Vif or Vif/OrfA had replication rates equivalent to those of the virulent HV-FIV parental virus. Furthermore, small interfering RNA knockdown of feline APOBEC3 genes resulted in equalization of replication rates between LV-FIV and LV-FIV encoding HV-FIV Vif. These findings demonstrate that Vif-APOBEC interactions play a key role in controlling the replication and pathogenicity of this immunodeficiency-inducing virus in its native host species and that accessory genes act as mediators of lentiviral strain-specific virulence.

Draft genome sequence of an extensively drug-resistant Pseudomonas aeruginosa isolate belonging to ST644 isolated from a footpad infection in a Magellanic penguin (Spheniscus magellanicus).

PubMed

Sellera, Fábio P; Fernandes, Miriam R; Moura, Quézia; Souza, Tiago A; Nascimento, Cristiane L; Cerdeira, Louise; Lincopan, Nilton

2018-03-01

The incidence of multidrug-resistant bacteria in wildlife animals has been investigated to improve our knowledge of the spread of clinically relevant antimicrobial resistance genes. The aim of this study was to report the first draft genome sequence of an extensively drug-resistant (XDR) Pseudomonas aeruginosa ST644 isolate recovered from a Magellanic penguin with a footpad infection (bumblefoot) undergoing rehabilitation process. The genome was sequenced on an Illumina NextSeq ® platform using 150-bp paired-end reads. De novo genome assembly was performed using Velvet v.1.2.10, and the whole genome sequence was evaluated using bioinformatics approaches from the Center of Genomic Epidemiology, whereas an in-house method (mapping of raw whole genome sequence reads) was used to identify chromosomal point mutations. The genome size was calculated at 6436450bp, with 6357 protein-coding sequences and the presence of genes conferring resistance to aminoglycosides, β-lactams, phenicols, sulphonamides, tetracyclines, quinolones and fosfomycin; in addition, mutations in the genes gyrA (Thr83Ile), parC (Ser87Leu), phoQ (Arg61His) and pmrB (Tyr345His), conferring resistance to quinolones and polymyxins, respectively, were confirmed. This draft genome sequence can provide useful information for comparative genomic analysis regarding the dissemination of clinically significant antibiotic resistance genes and XDR bacterial species at the human-animal interface. Copyright © 2017 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.

Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of Bacterial Plasmids Conferring Carbapenem Resistance

PubMed Central

2018-01-01

ABSTRACT The hospital environment is a potential reservoir of bacteria with plasmids conferring carbapenem resistance. Our Hospital Epidemiology Service routinely performs extensive sampling of high-touch surfaces, sinks, and other locations in the hospital. Over a 2-year period, additional sampling was conducted at a broader range of locations, including housekeeping closets, wastewater from hospital internal pipes, and external manholes. We compared these data with previously collected information from 5 years of patient clinical and surveillance isolates. Whole-genome sequencing and analysis of 108 isolates provided comprehensive characterization of blaKPC/blaNDM-positive isolates, enabling an in-depth genetic comparison. Strikingly, despite a very low prevalence of patient infections with blaKPC-positive organisms, all samples from the intensive care unit pipe wastewater and external manholes contained carbapenemase-producing organisms (CPOs), suggesting a vast, resilient reservoir. We observed a diverse set of species and plasmids, and we noted species and susceptibility profile differences between environmental and patient populations of CPOs. However, there were plasmid backbones common to both populations, highlighting a potential environmental reservoir of mobile elements that may contribute to the spread of resistance genes. Clear associations between patient and environmental isolates were uncommon based on sequence analysis and epidemiology, suggesting reasonable infection control compliance at our institution. Nonetheless, a probable nosocomial transmission of Leclercia sp. from the housekeeping environment to a patient was detected by this extensive surveillance. These data and analyses further our understanding of CPOs in the hospital environment and are broadly relevant to the design of infection control strategies in many infrastructure settings. PMID:29437920

Next-generation sequencing for cancer drug development: the present and visions for the future.

PubMed

Kahn, Scott M

2014-03-01

NGS for Cancer Drug Development 24-26 September 2013, Boston, MA, USA Many of us who, prior to the -omics revolution, staunchly pursued the molecular basis of disease causation recognized the fundamental importance that biomarkers held for the eventuality of personalized medicine, more accurate diagnostics and targeted drug discovery. With slab sequencing apparatuses now mere memories relegated to the dusty reaches of old laboratory cabinets, we are fervently unraveling the complexities of many diseases through newer, more powerful innovative technologies. Quicker than ever before, we are achieving a deeper understanding of causative genetic lesions, perturbed pathways and the functions of altered networks. This has opened the door to a golden age of data generation that shows promise as a vital key to the successful treatment of human diseases. Hanson Wade recently organized a series of three related symposia that highlighted advances in industry and academic research in the areas of drug development, companion diagnostics and disease profiling: 'NGS for Cancer Drug Development' conference in Boston on 24-26 September 2013, the 'NGS Data Analysis' conference in San Francisco on 15-17 October 2013 and the 'World CDx' conference in Boston on 12-15 November 2013. These meetings provided forums for leaders to present advancements in personalized medicine, strategies for drug development, and innovations in diagnostics and other important areas. Their highly interactive nature also provided opportunities for industry and academic attendees to identify common hurdles that stand in the way of progress, (e.g., biomarker validation, analytical software limitations, data sharing, sample handling, regulatory and reimbursement restrictions), and to propose strategies for independent and community approaches toward overcoming such hurdles. In the interest of space, this review will be limited to the first in this series, the NGS for Cancer Drug Development conference, and its six major areas of focus.

A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing.

PubMed

Zhou, Ruoji; Xu, An; Wang, Donghui; Zhu, Dandan; Mata, Helen; Huo, Zijun; Tu, Jian; Liu, Mo; Mohamed, Alaa M T; Jewell, Brittany E; Gingold, Julian; Xia, Weiya; Rao, Pulivarthi H; Hung, Mien-Chie; Zhao, Ruiying; Lee, Dung-Fang

2018-03-01

The tumor suppressor gene TP53 is the most frequently mutated gene in human cancers. Many hot-spot mutations of TP53 confer novel functions not found in wild-type p53 and contribute to tumor development and progression. We report on the generation of a H1 human embryonic stem cell line carrying a homozygous TP53 R282W mutation using TALEN-mediated genome editing. The generated cell line demonstrates normal karyotype, maintains a pluripotent state, and is capable of generating a teratoma in vivo containing tissues from all three germ layers. Copyright © 2018 The Author(s). Published by Elsevier B.V. All rights reserved.

PREFACE: The 15th International Conference on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2015)

NASA Astrophysics Data System (ADS)

Livermore, C.; Velásquez-García, L. F.

2015-12-01

Greetings, and welcome to Boston, MA and PowerMEMS 2015 - the 15th International Conference on Micro and Nanotechnology for Power Generation and Energy Conversion Applications! The objective of PowerMEMS 2015 is to catalyze innovation in micro- and nano-scale technologies for the energy domain. The scope of the meeting ranges from basic principles, to materials and fabrication, to devices and systems, to applications. The many applications of Power MEMS range from the harvesting, storage, conversion and conditioning of energy, to integrated systems that manage these processes, to actuation, pumping, and propulsion. Our Conference aims to stimulate the exchange of insights and information, as well as the development of new ideas, in the Power MEMS field. Our goal is to allow the attendees to interact and network within our multidisciplinary community that includes professionals from many branches of science and engineering, as well as energy, policy, and entrepreneurial specialists interested in the commercialization of Power MEMS technologies. Since the first PowerMEMS in Sendai, Japan in 2000, the Conference has grown in size, reputation, impact, and technical breadth. This continuing growth is evident in this year's technical program, which includes an increasing number of papers on nanomaterials, additive manufacturing for energy systems, actuators, energy storage, harvesting strategies and integrated energy harvesting systems, for example. This year's technical program is highlighted by six plenary talks from prominent experts on piezoelectrics, robotic insects, thermoelectrics, photovoltaics, nanocomposite cathodes, and thermal energy conversion systems. The contributed program received a large number of abstract submissions this year, 169 in total. After careful review by the 34-member Technical Program Committee, a total of 135 papers were selected for presentation. The 60 contributed oral presentations are arranged in two parallel sessions. The 75 posters are arranged in a ''two-in-one'' poster session in which the poster session time is divided in two; half the posters will be presented during each half-session, allowing the poster presenters to also browse the posters during the poster session. Posters will remain up during the meeting, so please feel free to peruse them at your leisure. The Proceedings will be visible and accessible through IOP after conclusion of the Conference. We hope to maximize interaction among participants and stimulate lively discussion through the technical program and social events. For the first time at the Conference, a great many sponsors are making their presence known at PowerMEMS through tabletop displays, which will catalyze engaging conversations between our industrial partners and the research community. Also, for the first time at PowerMEMS, we will host a Rump Session - an informal event in which Conference participants engage in honest and fun discussions of topics of relevance to the community while strengthening bonds within the community. This meeting is made possible by many generous contributions of time, effort, and financial support. Thanks are due to the Technical Program Committee for their intensive efforts in reviewing abstract submissions, and to the International Steering Committee for their advice and support. We are grateful to Preferred Meeting Management Inc. for their many and key contributions to the management and organization of our Conference. Finally, we gratefully acknowledge the organizational and financial support provided for this meeting by the Transducers Research Foundation, Northeastern University, the Massachusetts Institute of Technology, and our exhibitors and other supporters. We hope that you find our Conference enjoyable and fruitful, and that you enjoy your stay in the Boston, MA area.

Monitoring crack extension in fracture toughness tests by ultrasonics

NASA Technical Reports Server (NTRS)

Klima, S. J.; Fisher, D. M.; Buzzard, R. J.

1975-01-01

An ultrasonic method was used to observe the onset of crack extension and to monitor continued crack growth in fracture toughness specimens during three point bend tests. A 20 MHz transducer was used with commercially available equipment to detect average crack extension less than 0.09 mm. The material tested was a 300-grade maraging steel in the annealed condition. A crack extension resistance curve was developed to demonstrate the usefulness of the ultrasonic method for minimizing the number of tests required to generate such curves.

Proceedings of the 1st Army Installation Energy Security and Independence Conference

DTIC Science & Technology

2007-03-01

robustness of Transmission and Distribution system, and that pro- motes the use of demand response, CHP, and use of renewable intermit - ERDC/CERL TR...charged during low load periods. • Generation is run at optimum level during high loads. • Storage follows load and provides fast power balance during

76 FR 23340 - Advisory Committee on Reactor Safeguards; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-26

... Thursday, October 21, 2010 (75 FR 65038-65039). Thursday, May 12, 2011, Conference Room T2-B1, 11545... Safety Evaluation Report Associated with the License Renewal Application for the Hope Creek Generating... NRC staff and PSEG Nuclear, LLC regarding the final safety evaluation report (SER) associated with the...

9th Annual Science and Engineering Technology Conference

DTIC Science & Technology

2008-04-17

Disks Composite Technology Titanium Aluminides Processing Microstructure Properties Curve Generator Go-Forward: Integrated Materials & Process Models...Initiatives Current DPA/T3s: Atomic Layer Deposition Hermetic Coatings: ...domestic ALD for electronic components; transition to fabrication process ...Production windows estim • Process capability fully established >Production specifications in place >Supply chain established •All necessary property

International Conference on Numerical Grid Generation in Computational Fluid Dynamics

DTIC Science & Technology

1989-04-30

Joseph M. Juarez DFVLR SM -TS The Aerospace Corp. Bunsenstr-10 PO Box 92957 M5/559 D-3406 Gottingen Los Angeles CA 90009 F R Germany Klaus A. Hoffmann...Washington, D.C. 20332 Troy, NY 12180 Per Nielsen R. Raghunath Graduate Student Research Fellow Laboratory for Applied Math. Physic NOAA / AOML

The First NREL Conference on thermophotovoltaic generation of electricity: Proceedings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1994-08-01

This collection of abstracts from the July 1994 meeting contains various information on thermophotovoltaic (TPV) conversion and converters. Discussed topics include: the current status of TPV conversion, TPV tutorials, heat source and emitter technologies, advanced TPV devices, selective emitter theory and practice, programmatic and systems issues, device fundamentals, and device and material characterization.

Statistical and Adaptive Signal Processing for UXO Discrimination for Next-Generation Sensor Data

DTIC Science & Technology

2009-09-01

using the energies of all polarizations as features in a KNN classifier variant resulted in 100% probability of detection at a probability of false...International Conference on Acoustics, Speech , and Signal Processing, vol. V, 2005, pp. 885-888. [12] C. Kreucher, K. Kastella, and A. O. Hero

Enhancing Postgraduate Learning and Development: A Participatory Action Learning and Action Research Approach through Conferences

ERIC Educational Resources Information Center

Wood, Lesley; Louw, Ina; Zuber-Skerritt, Ortrun

2017-01-01

As supervisors who advocate the transformational potential of research both to generate theory and practical and emancipatory outcomes, we practice participatory action learning and action research (PALAR). This paper offers an illustrative case of how supervision practices based on action learning can foster emancipatory and lifelong learning…

Final report. (This is a conference support, no publications were delivered)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, F.; Hill, R.; Zohar, Y.

2004-05-01

The Marine Biotechnology Conference held in Chiba, Japan (September 17-21, 2003) was a very successful meeting. Approximately 700 participants from 32 different countries attended this meeting. The proceedings of MBC2003 will be published in a special edition of the journal Marine Biotechnology. Three PIs, Drs. Feng Chen, Russell Hill, and Yonathan Zohar from the Center of Marine Biotechnology led effort to raise a total of $38,000 from NSF, DOE, Maryland Sea Grant, and Martek BioScience Corp to assist 28 U.S. scientists from various research institutions to participate this conference. Among the 28 awardees, 14 are graduate students and postdocs, andmore » five are female scientists. All the awardees gave either oral or poster presentations at the conference. Each graduate student and junior scientist received $1,375 (the maximum amount) in support towards travel to this conference, and each senior scientist (including tenure-track assistant professor) received $655 (the maximum amount). Specifically, eight scientists (3 seniors and 5 juniors) were supported by the DOE travel award (see attached table). A Grants Specialist at the Center of Marine Biotechnology, Mrs. Nanci Henningsen at COMB took care of all the reimbursements, which were completed on January 16, 2004. The availability of travel fund was advertised on the website of MBC2003 and also through email contacts. During the meeting, these travel funds were acknowledged through slide presentation in each plenary session and in the two poster sessions in the exhibition hall (see attached). Because several people decided in the last minute that they did not need the funds, there is still about $4,142 remaining in the DOE fund. Per my conversation with Dr. Anna Palmisano, the Program Manager at DOE, we will use the remaining $4,142 of DOE fund to support graduate student attendance at major conferences related to Marine Biotechnology in 2004. We have identified several relevant meetings as followed: (1) The Fifth International Symposium on the Biology of Actinomyces, December, 2003, Australia; (2) Ocean Research Conference Hawaii, February 16-20, 2004; (3) World Aquaculture Conference Hawaii, March 1-5, 2004; and (4) The 10th International Symposium of Microbial Ecology, Cancun, Mexico, August, 2004. The remaining funds will be used to assist partial traveling cost for the graduate students who participate and present in the meetings mentioned above. The amount of support and number of awardees will be decided by PIs Drs. Feng Chen, Russell Hill, and Yonathan Zohar. The original grant (DE-FG02-03ER63563) ended by December 31, 2003, Dr. Palmisano suggested to us to contact DOE operations at Chicago for a no cost extension. Please let us know if more information is needed.« less

Effective medical treatment of opiate addiction. National Consensus Development Panel on Effective Medical Treatment of Opiate Addiction.

PubMed

1998-12-09

To provide clinicians, patients, and the general public with a responsible assessment of the effective approaches to treat opiate dependence. A nonfederal, nonadvocate, 12-member panel representing the fields of psychology, psychiatry, behavioral medicine, family medicine, drug abuse, epidemiology, and the public. In addition, 25 experts from these same fields presented data to the panel and a conference audience of 600. Presentations and discussions were divided into 3 phases over 2 1/2 days: (1) presentations by investigators working in the areas relevant to the consensus questions during a 2-day public session; (2) questions and statements from conference attendees during open discussion periods that are part of the public session; and (3) closed deliberations by the panel during the remainder of the second day and morning of a third day. The conference was organized and supported by the Office of Medical Applications of Research, National Institutes of Health. The literature was searched through MEDLINE and other National Library of Medicine and online databases from January 1994 through September 1997 and an extensive bibliography of 941 references was provided to the panel and the conference audience. Experts prepared abstracts for their presentations as speakers at the conference with relevant citations from the literature. Scientific evidence was given precedence over clinical anecdotal experience. The panel, answering predefined questions, developed its conclusions based on the scientific evidence presented in open forum and the scientific literature. The panel composed a draft statement that was read in its entirety and circulated to the experts and the audience for comment. Thereafter, the panel resolved conflicting recommendations and released a revised statement at the end of the conference. The panel finalized the revisions within a few weeks after the conference. The draft statement was made available on the World Wide Web immediately following its release at the conference and was updated with the panel's final revisions. Opiate dependence is a brain-related medical disorder that can be effectively treated with significant benefits for the patient and society, and society must make a commitment to offer effective treatment for opiate dependence to all who need it. All persons dependent on opiates should have access to methadone hydrochloride maintenance therapy under legal supervision, and the US Office of National Drug Control Policy and the US Department of Justice should take the necessary steps to implement this recommendation. There is a need for improved training for physicians and other health care professionals. Training to determine diagnosis and treatment of opiate dependence should also be improved in medical schools. The unnecessary regulations of methadone maintenance therapy and other long-acting opiate agonist treatment programs should be reduced, and coverage for these programs should be a required benefit in public and private insurance programs.

Introduction: The 6th special issue of Mars Polar Science

NASA Astrophysics Data System (ADS)

Sori, Michael M.; Brown, Adrian J.

2018-07-01

Polar science at Mars has the ability to elucidate outstanding problems in the planet's history. The long-lived, kilometers-thick deposits at both poles hold a climate record that is still being steadily deciphered (e.g., Becerra et al., 2017), seasonal volatiles are important drivers of geomorphological change (e.g., Pilorget and Forget, 2015), and there is a growing recognition that water ice at lower latitudes is an important piece of the story in understanding polar processes (e.g., Bramson et al., 2015). Additionally, the icy volatiles trapped in the mid-latitudes will be an important resource for future human explorers (e.g., Viola et al., 2015). One task of this generation of Martian polar explorers is to understand the evolution of water as it cycles through the polar and mid-latitudes on geologic timescales in anticipation of its eventual utilization by the next generation of human and robotic explorers. To address these and other topics, the 6th International Mars Polar Science Conference was held in September 2016 in Reykjavik, Iceland (Smith et al., 2018). This special issue represents 16 papers presented at that conference.

Heat transfer with hockey-stick steam generator. [LMFBR

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moody, E; Gabler, M J

1977-11-01

The hockey-stick modular design concept is a good answer to future needs for reliable, economic LMFBR steam generators. The concept was successfully demonstrated in the 30 Mwt MSG test unit; scaled up versions are currently in fabrication for CRBRP usage, and further scaling has been accomplished for PLBR applications. Design and performance characteristics are presented for the three generations of hockey-stick steam generators. The key features of the design are presented based on extensive analytical effort backed up by extensive ancillary test data. The bases for and actual performance evaluations are presented with emphasis on the CRBRP design. The designmore » effort on these units has resulted in the development of analytical techniques that are directly applicable to steam generators for any LMFBR application. In conclusion, the hockey-stick steam generator concept has been proven to perform both thermally and hydraulically as predicted. The heat transfer characteristics are well defined, and proven analytical techniques are available as are personnel experienced in their use.« less

NIH Consensus Conference. Acupuncture.

PubMed

1998-11-04

To provide clinicians, patients, and the general public with a responsible assessment of the use and effectiveness of acupuncture to treat a variety of conditions. A nonfederal, nonadvocate, 12-member panel representing the fields of acupuncture, pain, psychology, psychiatry, physical medicine and rehabilitation, drug abuse, family practice, internal medicine, health policy, epidemiology, statistics, physiology, biophysics, and the representatives of the public. In addition, 25 experts from these same fields presented data to the panel and a conference audience of 1200. Presentations and discussions were divided into 3 phases over 2 1/2 days: (1) presentations by investigators working in areas relevant to the consensus questions during a 2-day public session; (2) questions and statements from conference attendees during open discussion periods that were part of the public session; and (3) closed deliberations by the panel during the remainder of the second day and morning of the third. The conference was organized and supported by the Office of Alternative Medicine and the Office of Medical Applications of Research, National Institutes of Health, Bethesda, Md. The literature, produced from January 1970 to October 1997, was searched through MEDLINE, Allied and Alternative Medicine, EMBASE, and MANTIS, as well as through a hand search of 9 journals that were not indexed by the National Library of Medicine. An extensive bibliography of 2302 references was provided to the panel and the conference audience. Expert speakers prepared abstracts of their own conference presentations with relevant citations from the literature. Scientific evidence was given precedence over clinical anecdotal experience. The panel, answering predefined questions, developed their conclusions based on the scientific evidence presented in the open forum and scientific literature. The panel composed a draft statement, which was read in its entirety and circulated to the experts and the audience for comment. Thereafter, the panel resolved conflicting recommendations and released a revised statement at the end of the conference. The panel finalized the revisions within a few weeks after the conference. The draft statement was made available on the World Wide Web immediately following its release at the conference and was updated with the panel's final revisions within a few weeks of the conference. The statement is available at http://consensus.nih.gov. Acupuncture as a therapeutic intervention is widely practiced in the United States. Although there have been many studies of its potential usefulness, many of these studies provide equivocal results because of design, sample size, and other factors. The issue is further complicated by inherent difficulties in the use of appropriate controls, such as placebos and sham acupuncture groups. However, promising results have emerged, for example, showing efficacy of acupuncture in adult postoperative and chemotherapy nausea and vomiting and in postoperative dental pain. There are other situations, such as addiction, stroke rehabilitation, headache, menstrual cramps, tennis elbow, fibromyalgia, myofascial pain, osteoarthritis, low back pain, carpal tunnel syndrome, and asthma, in which acupuncture may be useful as an adjunct treatment or an acceptable alternative or be included in a comprehensive management program. Further research is likely to uncover additional areas where acupuncture interventions will be useful.