Policy Reform Efforts and Equal Opportunity--An Evidence-Based Link? An Analysis of Current Sector Reforms in the Austrian School System

ERIC Educational Resources Information Center

Geppert, Corinna; Bauer-Hofmann, Sonja; Hopmann, Stefan Thomas

2012-01-01

The main focus of the present paper is to answer two different questions: From the perspective of Austrian education policy, which core areas of schooling are linked to the demand for equal opportunity? Can these reform efforts sustain the current state of research, and what are the consequences for schooling? The paper draws on an analysis by…

Focusing effect of bent GaAs crystals for γ-ray Laue lenses: Monte Carlo and experimental results

NASA Astrophysics Data System (ADS)

Virgilli, E.; Frontera, F.; Rosati, P.; Bonnini, E.; Buffagni, E.; Ferrari, C.; Stephen, J. B.; Caroli, E.; Auricchio, N.; Basili, A.; Silvestri, S.

2016-02-01

We report on results of observation of the focusing effect from the planes (220) of Gallium Arsenide (GaAs) crystals. We have compared the experimental results with the Monte Carlo simulations of the focusing capability of GaAs tiles performed with a dedicated ray-tracer. The GaAs tiles were bent using a lapping process developed at the cnr/imem - Parma (Italy) in the framework of the laue project, funded by ASI, dedicated to build a broad band Laue lens prototype for astrophysical applications in the hard X-/soft γ-ray energy range (80-600 keV). We present and discuss the results obtained from their characterization, mainly in terms of focusing capability. Bent crystals will significantly increase the signal to noise ratio of a telescope based on a Laue lens, consequently leading to an unprecedented enhancement of sensitivity with respect to the present non focusing instrumentation.

The interplay between structure and agency in shaping the mental health consequences of job loss

PubMed Central

2013-01-01

Background Job loss is a discrete life event, with multiple adverse consequences for physical and mental health and implications for agency. Our research explores the consequences of job loss for retrenched workers’ mental health by examining the interplay between their agency and the structures shaping their job loss experiences. Methods We conducted two waves of in-depth, semi-structured interviews with a sample of 33 of the more than 1000 workers who lost their jobs at Mitsubishi Motors in South Australia during 2004 and 2005 as a result of industry restructuring. Interviews capturing the mental health consequences of job loss were recorded and transcribed verbatim. Thematic analysis was employed to determine the health consequences of the job loss and the impact of structural factors. Results Main themes that emerged from the qualitative exploration of the psychological distress of job loss included stress, changes to perceived control, loss of self-esteem, shame and loss of status, experiencing a grieving process, and financial strain. Drawing on two models of agency we identified the different ways workers employed their agency, and how their agency was enabled, but mainly constrained, when dealing with job loss consequences. Conclusions Respondents’ accounts support the literature on the moderating effects of economic resources such as redundancy packages. The results suggest the need for policies to put more focus on social, emotional and financial investment to mediate the structural constraints of job loss. Our study also suggests that human agency must be understood within an individual’s whole of life circumstances, including structural and material constraints, and the personal or interior factors that shape these circumstances. PMID:23384322

Gendered dimensions of obesity in childhood and adolescence

PubMed Central

Sweeting, Helen N

2008-01-01

Background The literature on childhood and adolescent obesity is vast. In addition to producing a general overview, this paper aims to highlight gender differences or similarities, an area which has tended not to be the principal focus of this literature. Methods Databases were searched using the terms 'obesity' and 'child', 'adolescent', 'teenager', 'youth', 'young people', 'sex', 'gender', 'masculine', 'feminine', 'male', 'female', 'boy' and 'girl' (or variations on these terms). In order to limit the potential literature, the main focus is on other reviews, both general and relating to specific aspects of obesity. Results The findings of genetic studies are similar for males and females, and differences in obesity rates as defined by body mass index are generally small and inconsistent. However, differences between males and females due to biology are evident in the patterning of body fat, the fat levels at which health risks become apparent, levels of resting energy expenditure and energy requirements, ability to engage in certain physical activities and the consequences of obesity for the female reproductive system. Differences due to society or culture include food choices and dietary concerns, overall physical activity levels, body satisfaction and the long-term psychosocial consequences of childhood and adolescent obesity. Conclusion This review suggests differences between males and females in exposure and vulnerability to obesogenic environments, the consequences of child and adolescent obesity, and responses to interventions for the condition. A clearer focus on gender differences is required among both researchers and policy makers within this field. PMID:18194542

Gendered dimensions of obesity in childhood and adolescence.

PubMed

Sweeting, Helen N

2008-01-14

The literature on childhood and adolescent obesity is vast. In addition to producing a general overview, this paper aims to highlight gender differences or similarities, an area which has tended not to be the principal focus of this literature. Databases were searched using the terms 'obesity' and 'child', 'adolescent', 'teenager', 'youth', 'young people', 'sex', 'gender', 'masculine', 'feminine', 'male', 'female', 'boy' and 'girl' (or variations on these terms). In order to limit the potential literature, the main focus is on other reviews, both general and relating to specific aspects of obesity. The findings of genetic studies are similar for males and females, and differences in obesity rates as defined by body mass index are generally small and inconsistent. However, differences between males and females due to biology are evident in the patterning of body fat, the fat levels at which health risks become apparent, levels of resting energy expenditure and energy requirements, ability to engage in certain physical activities and the consequences of obesity for the female reproductive system. Differences due to society or culture include food choices and dietary concerns, overall physical activity levels, body satisfaction and the long-term psychosocial consequences of childhood and adolescent obesity. This review suggests differences between males and females in exposure and vulnerability to obesogenic environments, the consequences of child and adolescent obesity, and responses to interventions for the condition. A clearer focus on gender differences is required among both researchers and policy makers within this field.

Aging and social expenditures in Italy: some issues associated with population projections.

PubMed

Terra Abrami, V

1990-01-01

"After describing the main results of the recent Italian population projections, and some possible consequences...aging may have on social expenditures, this paper focuses on attempts to improve the accuracy of development assumptions, with special regard to natural components. Emphasis is placed on the importance of applying specific methodological tools to define self-explanatory assumptions for fertility and mortality and to produce projections which could be considered, with reasonable limitations, as real forecasts." excerpt

A Method for Dynamic Risk Assessment and Management of Rockbursts in Drill and Blast Tunnels

NASA Astrophysics Data System (ADS)

Liu, Guo-Feng; Feng, Xia-Ting; Feng, Guang-Liang; Chen, Bing-Rui; Chen, Dong-Fang; Duan, Shu-Qian

2016-08-01

Focusing on the problems caused by rockburst hazards in deep tunnels, such as casualties, damage to construction equipment and facilities, construction schedule delays, and project cost increase, this research attempts to present a methodology for dynamic risk assessment and management of rockbursts in D&B tunnels. The basic idea of dynamic risk assessment and management of rockbursts is determined, and methods associated with each step in the rockburst risk assessment and management process are given, respectively. Among them, the main parts include a microseismic method for early warning the occurrence probability of rockburst risk, an estimation method that aims to assess potential consequences of rockburst risk, an evaluation method that utilizes a new quantitative index considering both occurrence probability and consequences for determining the level of rockburst risk, and the dynamic updating. Specifically, this research briefly describes the referenced microseismic method of warning rockburst, but focuses on the analysis of consequences and associated risk assessment and management of rockburst. Using the proposed method of risk assessment and management of rockburst, the occurrence probability, potential consequences, and the level of rockburst risk can be obtained in real-time during tunnel excavation, which contributes to the dynamic optimisation of risk mitigation measures and their application. The applicability of the proposed method has been verified by those cases from the Jinping II deep headrace and water drainage tunnels at depths of 1900-2525 m (with a length of 11.6 km in total for D&B tunnels).

Relationship among values, beliefs, norms and ecological behaviour.

PubMed

González López, Antonio; Amérigo Cuervo-Arango, María

2008-11-01

The present study focuses mainly on the relationship between psychological constructs and ecological behaviour. Empirical analysis links personal values, ecological beliefs, consequences of environmental conditions, denial of ecological obligation, environmental control, personal norms and environment protection behaviour. Survey data from a path analysis of a Spanish sample of 403 individuals were used, showing that ecological beliefs, personal norms and eco-altruistic values have become the main psychological explanatory variables of environment protective behaviour. Ecological beliefs, when measured by the New Ecological Paradigm Scale, affected ecological behaviour decisively. Environmental and altruistic values were shown to be related to moral obligation, and a basic variable to understand behaviour. Personal norm mediated the effects of values and environmental control on ecological behaviour.

Andrei Andreevich Bolibrukh's works on the analytic theory of differential equations

NASA Astrophysics Data System (ADS)

Anosov, Dmitry V.; Leksin, Vladimir P.

2011-02-01

This paper contains an account of A.A. Bolibrukh's results obtained in the new directions of research that arose in the analytic theory of differential equations as a consequence of his sensational counterexample to the Riemann-Hilbert problem. A survey of results of his students in developing topics first considered by Bolibrukh is also presented. The main focus is on the role of the reducibility/irreducibility of systems of linear differential equations and their monodromy representations. A brief synopsis of results on the multidimensional Riemann-Hilbert problem and on isomonodromic deformations of Fuchsian systems is presented, and the main methods in the modern analytic theory of differential equations are sketched. Bibliography: 69 titles.

Cost-Utility Analysis: Current Methodological Issues and Future Perspectives

PubMed Central

Nuijten, Mark J. C.; Dubois, Dominique J.

2011-01-01

The use of cost–effectiveness as final criterion in the reimbursement process for listing of new pharmaceuticals can be questioned from a scientific and policy point of view. There is a lack of consensus on main methodological issues and consequently we may question the appropriateness of the use of cost–effectiveness data in health care decision-making. Another concern is the appropriateness of the selection and use of an incremental cost–effectiveness threshold (Cost/QALY). In this review, we focus mainly on only some key methodological concerns relating to discounting, the utility concept, cost assessment, and modeling methodologies. Finally we will consider the relevance of some other important decision criteria, like social values and equity. PMID:21713127

Methods for nuclear air-cleaning-system accident-consequence assessment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Andrae, R.W.; Bolstad, J.W.; Gregory, W.S.

1982-01-01

This paper describes a multilaboratory research program that is directed toward addressing many questions that analysts face when performing air cleaning accident consequence assessments. The program involves developing analytical tools and supportive experimental data that will be useful in making more realistic assessments of accident source terms within and up to the atmospheric boundaries of nuclear fuel cycle facilities. The types of accidents considered in this study includes fires, explosions, spills, tornadoes, criticalities, and equipment failures. The main focus of the program is developing an accident analysis handbook (AAH). We will describe the contents of the AAH, which include descriptionsmore » of selected nuclear fuel cycle facilities, process unit operations, source-term development, and accident consequence analyses. Three computer codes designed to predict gas and material propagation through facility air cleaning systems are described. These computer codes address accidents involving fires (FIRAC), explosions (EXPAC), and tornadoes (TORAC). The handbook relies on many illustrative examples to show the analyst how to approach accident consequence assessments. We will use the FIRAC code and a hypothetical fire scenario to illustrate the accident analysis capability.« less

Wilckodontics - A Novel Synergy in Time to Save Time

PubMed Central

K., Sirisha; M., Srinivas; D., Ravindranath; Gowd, Pratap

2014-01-01

The systematic search for improvements in orthodontic therapy is shared by several dental specalities especially periodontics. Rapid orthodontic treatment procedures are now focusing on performing Alveolar Corticotomies (ACS) shortly before the application of orthodontic forces. This method has been suggested to enhance tooth movement and, consequently, reduces orthodontic treatment time as a whole. Thus, this article attempts to review the historical perspective of these therapeutic approaches, discusses the biological reasons underlying its use, mentions its main indications and contraindications and its modifications. PMID:24596806

Impact of climatic factors on energy consumption during the heating season

NASA Astrophysics Data System (ADS)

Ginzburg, A. S.; Reshetar, O. A.; Belova, I. N.

2016-09-01

Global and regional climate changes produce a significant effect on energy production and consumption, especially on heating and air conditioning in residential, industrial, commercial, and office rooms. In Russia, with its contracting climate conditions, energy consumption varies a lot in different regions. Thus, we have to review the dynamics of energy consumption during the cold season individually for each region of the country. We analyzed the dynamics of duration and temperature of the heating season in Moscow region and completed a comparative study of heat energy consumption, actual and calculated based on the 'degreedays' concept, in the municipal economy of Moscow during the last decade. Based on the actual data analysis, we proved that conservation of energy resources in a large city relies not so much on a shortening of the heating period as on the growth of atmospheric air temperature in winter. The projected climate warming in the Moscow region in the nearest decades, along with measures of energy conservation, will promote a significant reduction in energy consumption of the municipal economy in winter. The results shown in this article were obtained in the process of preparing and implementing project no. 16-17-00114 by the Russian Science Foundation "Analysis of an impact of the regional climate change on the residential and commercial energy consumption of Russian megacities," within the main area of focus of the Russian Science Foundation, which is "Fundamental Research and Exploration in Main Topical Areas of Focus." The project was implemented within the framework of the scientific area of focus, which is "Reduction of the Risk and Mitigation of Consequences of Natural and Man-made Disasters" ("Studying Economical, Political, and Social Consequences of Global Climate Changes" problem).

Australian television news coverage of alcohol, health and related policies, 2005 to 2010: implications for alcohol policy advocates.

PubMed

Fogarty, Andrea S; Chapman, Simon

2012-12-01

To describe television news coverage between 2005 and 2010 of alcohol, health and relevant alcohol-control policies, with a view to informing policy advocacy. A content analysis of all alcohol stories archived by the Australian Health News Research Collaboration. We recorded what triggered a news item, the main topics covered, whether risks to health were communicated, whether alcohol-control policies were featured and which news-actors appeared. We identified 612 stories, where 69.2% were triggered by a particular newsworthy incident or the release of new findings. The most frequently reported alcohol stories were focused on associated harms (30.2%) and 'binge drinking' (19.0%). A majority (75.3%) reported a variety of positive and negative health effects, yet mainly focused on short-term consequences. Combined, 63% mentioned an alcohol-control policy, yet no one particular policy was featured in more than 10% of all stories. The most commonly featured news-actors included public-health professionals (50.0%), members of affected communities (28.4%) and government representatives (24.3%) Problems related to alcohol were well-established foci of news attention and reportage and covered a broad spectrum of issues related to public health goals, yet less coverage centred on long-term health consequences or effective policy solutions. Future policy advocacy could focus on moving the debate away from simple problem definition to better communication of long-term health risks, existing policies, and evidence of their effectiveness and arguments for their adoption. Future research might consider audience understanding of the information. © 2012 The Authors. ANZJPH © 2012 Public Health Association of Australia.

Synthetic microbial ecology and the dynamic interplay between microbial genotypes.

PubMed

Dolinšek, Jan; Goldschmidt, Felix; Johnson, David R

2016-11-01

Assemblages of microbial genotypes growing together can display surprisingly complex and unexpected dynamics and result in community-level functions and behaviors that are not readily expected from analyzing each genotype in isolation. This complexity has, at least in part, inspired a discipline of synthetic microbial ecology. Synthetic microbial ecology focuses on designing, building and analyzing the dynamic behavior of ‘ecological circuits’ (i.e. a set of interacting microbial genotypes) and understanding how community-level properties emerge as a consequence of those interactions. In this review, we discuss typical objectives of synthetic microbial ecology and the main advantages and rationales of using synthetic microbial assemblages. We then summarize recent findings of current synthetic microbial ecology investigations. In particular, we focus on the causes and consequences of the interplay between different microbial genotypes and illustrate how simple interactions can create complex dynamics and promote unexpected community-level properties. We finally propose that distinguishing between active and passive interactions and accounting for the pervasiveness of competition can improve existing frameworks for designing and predicting the dynamics of microbial assemblages.

Breaking the Silence: Sexual Harassment of Mexican Women Farmworkers.

PubMed

Kim, Nicole Jung-Eun; Vásquez, Victoria Breckwich; Torres, Elizabeth; Nicola, R M Bud; Karr, Catherine

2016-01-01

The purpose of this study was to understand Mexican women farmworkers' perceptions of workplace sexual harassment, its related factors and consequences, and potential points of intervention. This community-based participatory research study conducted focus groups with 20 women farmworkers in rural Washington. Four coders analyzed and gleaned interpretations from verbatim transcripts. Three main themes were identified. It was learned that women farmworkers: (1) frequently experienced both quid pro quo and hostile work environment forms of sexual harassment; (2) faced employment and health consequences due to the harassment; and (3) felt that both individual- and industry-level changes could prevent the harassment. Based on these findings, the authors identified three sets of risk factors contributing to workplace sexual harassment and recommend using a multilevel approach to prevent future harassment in the agriculture industry.

Breaking the Silence: Sexual Harassment of Mexican Women Farmworkers

PubMed Central

Kim, Nicole Jung-Eun; Vásquez, Victoria Breckwich; Torres, Elizabeth; Bud Nicola, R. M.; Karr, Catherine

2018-01-01

The purpose of this study was to understand Mexican women farmworkers’ perceptions of workplace sexual harassment, its related factors and consequences, and potential points of intervention. This community-based participatory research study conducted focus groups with 20 women farmworkers in rural Washington. Four coders analyzed and gleaned interpretations from verbatim transcripts. Three main themes were identified. It was learned that women farmworkers: (1) frequently experienced both quid pro quo and hostile work environment forms of sexual harassment; (2) faced employment and health consequences due to the harassment; and (3) felt that both individual-and industry-level changes could prevent the harassment. Based on these findings, the authors identified three sets of risk factors contributing to workplace sexual harassment and recommend using a multilevel approach to prevent future harassment in the agriculture industry. PMID:26797165

Patient and visitor violence in the general hospital, occurrence, staff interventions and consequences: a cross-sectional survey.

PubMed

Hahn, Sabine; Hantikainen, Virpi; Needham, Ian; Kok, Gerjo; Dassen, Theo; Halfens, Ruud J G

2012-12-01

AIM.: This study focuses on the experience of healthcare staff with regard to patient and visitor violence in a general hospital. The occurrence of patient and visitor violence, staffs' interventions and the consequences of violence for different professions are investigated. There is a lack of studies describing the factors influencing the occurrence of patient and visitor violence, intervention strategies and consequences. Existing studies often focus on nurses' experiences and single interactive factors between staff and patients/visitors involved. A cross-sectional survey. The survey was conducted in 2007 including 2495 staff working on different wards in a Swiss university general hospital. The questionnaire used was the Survey of Violence Experienced by Staff German Version-Revised. Half of the staff experienced patient and visitor violence in the past 12 months and 11% in the past week. The age of the staff and the length of experience in their present workplace influenced the exposure to patient and visitor violence. Violence occurred mainly when staff carried out tasks involving close personal contact. Only 16% of the staff was trained in aggression management. The feeling of confidence in managing patient and visitor violence depended significantly on the organizational attitude towards violence. The principal interventions used were calming and informative discussion. To prevent patient and visitor violence and improve management strategies, training which focuses on communication skills, which is specific to the professional context and which emphasizes patient centeredness, need to be designed and implemented. A strong organizational commitment is imperative to reduce violence. © 2012 Blackwell Publishing Ltd.

ERP correlates of processing the auditory consequences of own versus observed actions.

PubMed

Ghio, Marta; Scharmach, Katrin; Bellebaum, Christian

2018-06-01

Research has so far focused on neural mechanisms that allow us to predict the sensory consequences of our own actions, thus also contributing to ascribing them to ourselves as agents. Less attention has been devoted to processing the sensory consequences of observed actions ascribed to another human agent. Focusing on audition, there is consistent evidence of a reduction of the auditory N1 ERP for self- versus externally generated sounds, while ERP correlates of processing sensory consequences of observed actions are mainly unexplored. In a between-groups ERP study, we compared sounds generated by self-performed (self group) or observed (observation group) button presses with externally generated sounds, which were presented either intermixed with action-generated sounds or in a separate condition. Results revealed an overall reduction of the N1 amplitude for processing action- versus externally generated sounds in both the intermixed and the separate condition, with no difference between the groups. Further analyses, however, suggested that an N1 attenuation effect relative to the intermixed condition at frontal electrode sites might exist only for the self but not for the observation group. For both groups, we found a reduction of the P2 amplitude for processing action- versus all externally generated sounds. We discuss whether the N1 and the P2 reduction can be interpreted in terms of predictive mechanisms for both action execution and observation, and to what extent these components might reflect also the feeling of (self) agency and the judgment of agency (i.e., ascribing agency either to the self or to others). © 2017 Society for Psychophysiological Research.

The cystic fibrosis microbiome in an ecological perspective and its impact in antibiotic therapy.

PubMed

Magalhães, Andreia P; Azevedo, Nuno F; Pereira, Maria O; Lopes, Susana P

2016-02-01

The recent focus on the cystic fibrosis (CF) complex microbiome has led to the recognition that the microbes can interact between them and with the host immune system, affecting the disease progression and treatment routes. Although the main focus remains on the interactions between traditional pathogens, growing evidence supports the contribution and the role of emergent species. Understanding the mechanisms and the biological effects involved in polymicrobial interactions may be the key to improve effective therapies and also to define new strategies for disease control. This review focuses on the interactions between microbe-microbe and host-microbe, from an ecological point of view, discussing their impact on CF disease progression. There are increasing indications that these interactions impact the success of antimicrobial therapy. Consequently, a new approach where therapy is personalized to patients by taking into account their individual CF microbiome is suggested.

Considerations for the definition, measurement, consequences, and prevention of dating violence victimization among adolescent girls.

PubMed

Teten, Andra L; Ball, Barbara; Valle, Linda Anne; Noonan, Rita; Rosenbluth, Barri

2009-07-01

Violence experienced by adolescent girls from their dating partners poses considerable threat to their health and well-being. This report provides an overview of the prevalence and consequences of heterosexual teen dating violence and highlights the need for comprehensive prevention approaches to dating violence. We also discuss some considerations and future directions for the study and prevention of dating violence. We begin with a discussion of the definition of dating violence and also discuss measurement concerns and the need for evaluation of prevention strategies. Although women and men of all ages may be the victims or perpetrators, male-to-female dating violence experienced by adolescent girls is the main focus of this article. We incorporate research regarding girls' perpetration of dating violence where appropriate and as it relates to prevention.

[Improving Mental Health Literacy and Mental Illness Stigma in the Population of Hamburg].

PubMed

Lambert, Martin; Härter, Martin; Arnold, Detlef; Dirmaier, Jörg; Tlach, Lisa; Liebherz, Sarah; Sänger, Sylvia; Karow, Anne; Brandes, Andreas; Sielaff, Gyöngyver; Bock, Thomas

2015-07-01

Evidence shows that poor mental health literacy and stigmatization have negative consequences on mental health. However, studies on interventions to improve both are often heterogenic in methodology and results. The psychenet-campaign in Hamburg was developed and implemented in collaboration with patients and relatives and comprised multidimensional interventions focusing on education and contact to patients. The main goals were the improvement of mental health literacy and destigmatization and the long-term implementation within Hamburg's mental health care system. © Georg Thieme Verlag KG Stuttgart · New York.

Constructive and Unconstructive Repetitive Thought

ERIC Educational Resources Information Center

Watkins, Edward R.

2008-01-01

The author reviews research showing that repetitive thought (RT) can have constructive or unconstructive consequences. The main unconstructive consequences of RT are (a) depression, (b) anxiety, and (c) difficulties in physical health. The main constructive consequences of RT are (a) recovery from upsetting and traumatic events, (b) adaptive…

Barking up the Wrong Tree: Why and How We May Need to Revise Alcohol Addiction Therapy

PubMed Central

Stock, Ann-Kathrin

2017-01-01

One of the main characteristics of alcohol abuse and addiction is the loss of control over alcohol intake and the continuation of drinking in the face of negative consequences. Mounting evidence strongly suggests that an alcohol-induced imbalance between goal-directed and habitual behavior may be one of the main driving factors of this key feature of addiction and furthermore play a key role in staying abstinent. Current therapies often focus only on deficient inhibitory control (i.e., goal-directed behavior), but largely neglect the potential of the well-functioning habit formation found in patients. Yet, focusing on intact habitual/automatic mechanisms in addition to or maybe even instead of deficient cognitive control might equip us with a more effective tool to battle the current alcohol abuse and addiction epidemic, especially with respect to more severely impacted patients who likely suffer from permanent alcohol-induced brain damage. Against this background, I would like to advocate the application and scientific evaluation of habit reversal therapy (HRT) for alcohol abuse and addiction. PMID:28611718

Advanced fire observation by the Intelligent Infrared Sensor prototype FOCUS on the International Space Station

NASA Astrophysics Data System (ADS)

Oertel, D.; Haschberger, P.; Tank, V.; Lanzl, F.; Zhukov, B.; Jahn, H.; Briess, K.; Lorenz, E.; Roeser, H.-P.; Ginati, A.; Tobehn, C.; Schulte in den Bäumen, J.; Christmann, U.

1999-01-01

Current and planned operational space-borne Earth observation systems provide spatially, radiometrically or temporally crude data for the detection and monitoring of high temperature phenomena on the surface of our planet. High Temperature Events (HTE) very often cause environmental disasters. Such HTE are forest and savannah fires, fires of open coal mines, volcanic activities and others (e.g. fires of oil wells, pipelines etc.). A simultaneous co-registration of a combination of infrared (IR) and visible (VIS) channels is the key for a reliable autonomous on-board detection of High Temperature Events (HTE) on Earth surface, such as vegetation fires and volcano eruptions. This is the main feature of the FOCUS experiment. Furthermore there are ecology-oriented objectives of the FOCUS experiment mainly related to spectrometric/imaging remote inspection and parameter extraction of selected HTEs, and to the assessment of some ecological consequences of HTEs, such as aerosol and gas emission. Based on own experimental work and supported by Co-Investigators from Italy, Greece, France, Spain, Russia and Germany, DLR proposed in 1997 to use the International Space Station (ISS) in its early utilization phase as a platform and test-bed for an Intelligent Infrared Sensor prototype FOCUS of a future Environmental Disaster Recognition Satellite System. FOCUS is considered by ESA as an important mission combining a number of proven technologies and observation techniques to provide the scientific and operational user community with key data for the classification and monitoring of forest fires. FOCUS was selected as one of five European ``Groupings'' to be flown as an externally mounted payload during the early utilisation phase of the ISS. The FOCUS Phase A Study will be performed by OHB-System, DLR and Zeiss from September 1998 until May 1999.

Food allergen selective thermal processing regimens may change oral tolerance in infancy.

PubMed

Kosti, R I; Triga, M; Tsabouri, S; Priftis, K N

2013-01-01

Food allergy can be considered a failure in the induction of oral tolerance. Recently, great interest has been focused on understanding the mechanisms and the contributing factors of oral tolerance development, hoping for new definitive interventions in the prevention and treatment of food allergy. Given that food processing may modify the properties and the nature of dietary proteins, several food processing methods could affect the allergenicity of these proteins and consequently may favour oral tolerance induction to food allergic children. Indeed, effective thermal food processing regimens of altering food proteins to reduce allergenicity have been recently reported in the literature. This article is mainly focused on the effect of selective thermal processing regimens on the main infant allergenic foods, with a potential clinical relevance on their allergenicity and therefore on oral tolerance induction. In the light of recent findings, the acquisition of tolerance in younger age and consequently the ability of young children to "outgrow" food allergy could be achieved through the application of selective thermal processing regimens on certain allergenic foods. Therefore, the ability of processed foods to circumvent clinical disease and at the same time to have an impact on the immune system and facilitate tolerance induction could be invaluable as a component of a successful therapeutic strategy. The opening in the new avenues of research in the use of processed foods in clinical practice for the amelioration of the impact on the quality of life of patients and possibly in food allergy prevention is warranted. Copyright © 2012 SEICAP. Published by Elsevier Espana. All rights reserved.

The Use of Lesson Study Combined with Content Representation in the Planning of Physics Lessons During Field Practice to Develop Pedagogical Content Knowledge

NASA Astrophysics Data System (ADS)

Juhler, Martin Vogt

2016-08-01

Recent research, both internationally and in Norway, has clearly expressed concerns about missing connections between subject-matter knowledge, pedagogical competence and real-life practice in schools. This study addresses this problem within the domain of field practice in teacher education, studying pre-service teachers' planning of a Physics lesson. Two means of intervention were introduced. The first was lesson study, which is a method for planning, carrying out and reflecting on a research lesson in detail with a learner and content-centered focus. This was used in combination with a second means, content representations, which is a systematic tool that connects overall teaching aims with pedagogical prompts. Changes in teaching were assessed through the construct of pedagogical content knowledge (PCK). A deductive coding analysis was carried out for this purpose. Transcripts of pre-service teachers' planning of a Physics lesson were coded into four main PCK categories, which were thereafter divided into 16 PCK sub-categories. The results showed that the intervention affected the pre-service teachers' potential to start developing PCK. First, they focused much more on categories concerning the learners. Second, they focused far more uniformly in all of the four main categories comprising PCK. Consequently, these differences could affect their potential to start developing PCK.

Spinorial Geometry and Supergravity

NASA Astrophysics Data System (ADS)

Gillard, Joe

2006-08-01

In the main part of this thesis, we present the foundations and initial results of the Spinorial Geometry formalism for solving Killing spinor equations. This method can be used for any supergravity theory, although we largely focus on D=11 supergravity. The D=5 case is investigated in an appendix. The exposition provides a comprehensive introduction to the formalism, and contains background material on the complex spin representations which, it is hoped, will provide a useful bridge between the mathematical literature and our methods. Many solutions to the D=11 Killing spinor equations are presented, and the consequences for the spacetime geometry are explored in each case. Also in this thesis, we consider another class of supergravity solutions, namely heterotic string backgrounds with (2,0) world-sheet supersymmetry. We investigate the consequences of taking alpha-prime corrections into account in the field equations, in order to remain consistent with anomaly cancellation, while requiring that spacetime supersymmetry is preserved.

The role of the cell wall in fungal pathogenesis

PubMed Central

Arana, David M.; Prieto, Daniel; Román, Elvira; Nombela, César; Alonso‐Monge, Rebeca; Pla, Jesús

2009-01-01

Summary Fungal infections are a serious health problem. In recent years, basic research is focusing on the identification of fungal virulence factors as promising targets for the development of novel antifungals. The wall, as the most external cellular component, plays a crucial role in the interaction with host cells mediating processes such as adhesion or phagocytosis that are essential during infection. Specific components of the cell wall (called PAMPs) interact with specific receptors in the immune cell (called PRRs), triggering responses whose molecular mechanisms are being elucidated. We review here the main structural carbohydrate components of the fungal wall (glucan, mannan and chitin), how their biogenesis takes place in fungi and the specific receptors that they interact with. Different model fungal pathogens are chosen to illustrate the functional consequences of this interaction. Finally, the identification of the key components will have important consequences in the future and will allow better approaches to treat fungal infections. PMID:21261926

For Whom Does Hate Crime Hurt More? A Comparison of Consequences of Victimization Across Motives and Crime Types.

PubMed

Mellgren, Caroline; Andersson, Mika; Ivert, Anna-Karin

2017-12-01

Hate crimes have been found to have more severe consequences than other parallel crimes that were not motivated by the offenders' hostility toward someone because of their real or perceived difference. Many countries today have hate crime laws that make it possible to increase the penalties for such crimes. The main critique against hate crime laws is that they punish thoughts. Instead, proponents of hate crime laws argue that sentence enhancement is justified because hate crimes cause greater harm. This study compares consequences of victimization across groups of victims to test for whom hate crimes hurt more. We analyzed data that were collected through questionnaires distributed to almost 3,000 students at Malmö University, Sweden, during 2013. The survey focused on students' exposure to, and experiences of, hate crime. A series of separate logistic regression analyses were performed, which analyzed the likelihood for reporting consequences following a crime depending on crime type, perceived motive, repeat victimization, gender, and age. Analyzed as one victim group, victims of hate crime more often reported any of the consequences following a crime compared with victims of parallel non-hate-motivated crimes. And, overall victims of threat more often reported consequences compared with victims of sexual harassment and minor assault. However, all hate crime victim groups did not report more consequences than the non-hate crime victim group. The results provide grounds for questioning that hate crimes hurt the individual victim more. It seems that hate crimes do not hurt all more but hate crimes hurt some victims of some crimes more in some ways.

A chronicle of galaxy mass assembly in the EAGLE simulation

NASA Astrophysics Data System (ADS)

Qu, Yan; Helly, John C.; Bower, Richard G.; Theuns, Tom; Crain, Robert A.; Frenk, Carlos S.; Furlong, Michelle; McAlpine, Stuart; Schaller, Matthieu; Schaye, Joop; White, Simon D. M.

2017-01-01

We analyse the mass assembly of central galaxies in the Evolution and Assembly of Galaxies and their Environments (EAGLE) hydrodynamical simulations. We build merger trees to connect galaxies to their progenitors at different redshifts and characterize their assembly histories by focusing on the time when half of the galaxy stellar mass was assembled into the main progenitor. We show that galaxies with stellar mass M* < 1010.5 M⊙ assemble most of their stellar mass through star formation in the main progenitor (`in situ' star formation). This can be understood as a consequence of the steep rise in star formation efficiency with halo mass for these galaxies. For more massive galaxies, however, an increasing fraction of their stellar mass is formed outside the main progenitor and subsequently accreted. Consequently, while for low-mass galaxies, the assembly time is close to the stellar formation time, the stars in high-mass galaxies typically formed long before half of the present-day stellar mass was assembled into a single object, giving rise to the observed antihierarchical downsizing trend. In a typical present-day M* ≥ 1011 M⊙ galaxy, around 20 per cent of the stellar mass has an external origin. This fraction decreases with increasing redshift. Bearing in mind that mergers only make an important contribution to the stellar mass growth of massive galaxies, we find that the dominant contribution comes from mergers with galaxies of mass greater than one-tenth of the main progenitor's mass. The galaxy merger fraction derived from our simulations agrees with recent observational estimates.

Chinese Outbound Investments in the Food Sector: Hungry for Much More!

PubMed

Wolff, Lutz-Christian

2014-01-01

This article analyses in its first part the almost dramatic increase of Chinese outbound investments in recent years with a special focus on the food industry. The second part outlines China's legal framework that has governed Chinese outbound investments over the past decade. In its main part this article explores recent steps to liberalize China's economy and assesses how the dismantling of existing restrictions will impact on Chinese investments overseas. It forecasts rather wide-ranging consequences for the non-Chinese food industry as food enterprises have become highly-sought after targets of Chinese outbound investment activities.

Understanding barriers to preventive health actions for occupational noise-induced hearing loss.

PubMed

Patel, D S; Witte, K; Zuckerman, C; Murray-Johnson, L; Orrego, V; Maxfield, A M; Meadows-Hogan, S; Tisdale, J; Thimons, E D

2001-01-01

A theoretically based formative evaluation was conducted with coal miners in the Appalachian Mountains who were at high risk for noise-induced hearing loss (NIHL). The results of four focus groups indicate that despite high levels of knowledge, strong perceived severity of negative consequences, and strong perceived susceptibility to hearing loss, two main categories of barriers (environmental and individual) keep coal miners from using their hearing protection devices (HPD). Further analysis suggests that the environmental factors, rather than individual variables, more strongly influence decisions against protective actions. Recommendations and practical implications are offered.

Institutional resources for communicable disease control in Europe: diversity across time and place.

PubMed

Mätzke, Margitta

2012-12-01

This commentary discusses the causes and consequences of diversity in how European countries organize communicable disease control. Drawing on the historical record of the US Centers for Disease Control and Prevention, it first reviews the main explanations of that diversity, with a focus on the political dynamic of building institutional capacity in the field of public health. It then examines the significance of institutional diversity in the process of Europeanization, and closes with a few thoughts on factors that have shaped the development of communicable disease control capacities in the United States and the European Union.

[Analysis of barriers to therapeutic adherence for Colombian women with HIV/AIDS: a question of health rights].

PubMed

Arrivillaga-Quintero, Marcela

2010-01-01

To identify and analyze HIV/AIDS treatment adherence among Colombian women. A qualitative, descriptive-interpretative study with content analysis was developed between 2008 and 2009. Sixty six women participated in five focus group discussions. To complement data, semi-structured interviews with seven key informants were conducted. Main barriers are determined structurally by the current Colombian health system, based on insurance market. The right to access to treatment in a timely and continuous manner, the rights to confidentiality and non discrimination, and the right to quality care with gender focus are affected among participant women. Consequently, adherence is negatively affected. The current Colombian health system determines critical processes affecting HIV/AIDS treatment adherence in women. However, further research must be conducted to identify specific associations with non-universal health systems.

Potential role of macrophages as immunoregulators of pregnancy

PubMed Central

Mor, Gil; Abrahams, Vikki M

2003-01-01

The role of the maternal immune system during pregnancy has focused mainly on the aspect of immune tolerance to the invading trophoblast and, therefore, fetus. While this is a critical aspect of reproductive immunology, it is also important to consider the function of the maternal immune system in the promotion of implantation and maintenance of pregnancy. Apoptosis or cell death is not the final stage in tissue development. The quick and effective removal of apoptotic cells by tissue macrophages represents a vital process preventing "leak" of self-antigens and promoting the production of proliferative/survival factors. One of the key requirements of apoptotic cell clearance is the resolution of inflammatory conditions, which, as in the case of pregnancy, may have lethal consequences. This review will focus on decidual macrophages and their role on apoptosis and cell clearance during pregnancy. PMID:14651752

Chronobiology by moonlight.

PubMed

Kronfeld-Schor, Noga; Dominoni, Davide; de la Iglesia, Horacio; Levy, Oren; Herzog, Erik D; Dayan, Tamar; Helfrich-Forster, Charlotte

2013-08-22

Most studies in chronobiology focus on solar cycles (daily and annual). Moonlight and the lunar cycle received considerably less attention by chronobiologists. An exception are rhythms in intertidal species. Terrestrial ecologists long ago acknowledged the effects of moonlight on predation success, and consequently on predation risk, foraging behaviour and habitat use, while marine biologists have focused more on the behaviour and mainly on reproduction synchronization with relation to the Moon phase. Lately, several studies in different animal taxa addressed the role of moonlight in determining activity and studied the underlying mechanisms. In this paper, we review the ecological and behavioural evidence showing the effect of moonlight on activity, discuss the adaptive value of these changes, and describe possible mechanisms underlying this effect. We will also refer to other sources of night-time light ('light pollution') and highlight open questions that demand further studies.

Chronobiology by moonlight

PubMed Central

Kronfeld-Schor, Noga; Dominoni, Davide; de la Iglesia, Horacio; Levy, Oren; Herzog, Erik D.; Dayan, Tamar; Helfrich-Forster, Charlotte

2013-01-01

Most studies in chronobiology focus on solar cycles (daily and annual). Moonlight and the lunar cycle received considerably less attention by chronobiologists. An exception are rhythms in intertidal species. Terrestrial ecologists long ago acknowledged the effects of moonlight on predation success, and consequently on predation risk, foraging behaviour and habitat use, while marine biologists have focused more on the behaviour and mainly on reproduction synchronization with relation to the Moon phase. Lately, several studies in different animal taxa addressed the role of moonlight in determining activity and studied the underlying mechanisms. In this paper, we review the ecological and behavioural evidence showing the effect of moonlight on activity, discuss the adaptive value of these changes, and describe possible mechanisms underlying this effect. We will also refer to other sources of night-time light (‘light pollution’) and highlight open questions that demand further studies. PMID:23825199

Polycystic ovarian syndrome.

PubMed

Khan, Khurshid A; Stas, Sameer; Kurukulasuriya, L Romayne

2006-01-01

Polycystic ovarian syndrome (PCOS) is the most common reproductive endocrinopathy of women during their childbearing years. A significant degree of controversy exists regarding the etiology of this syndrome, but there is a growing consensus that the key features include insulin resistance, androgen excess, and abnormal gonadotropin dynamics. Familial and genetic factors cause predisposition to PCOS. Insulin resistance and adiposity put women with PCOS at a higher risk for diabetes, hypertension, dyslipidemia, and cardiovascular disease. Even though the adverse health consequences associated with PCOS are substantial, most women are not aware of these risks. Early recognition and treatment of metabolic sequelae should be the main focus of clinicians. Lifestyle modifications, mainly a balanced diet, weight loss, and regular exercise, are of utmost importance. On the pharmacologic front, various therapies including metformin, thiazolidinediones, and others appear to be very promising in the management of cardiometabolic aspects of PCOS.

Sex-driven differences in immunological responses: challenges and opportunities for the immunotherapies of the third millennium.

PubMed

Mirandola, Leonardo; Wade, Raymond; Verma, Rashmi; Pena, Camilo; Hosiriluck, Nattamol; Figueroa, Jose A; Cobos, Everardo; Jenkins, Marjorie R; Chiriva-Internati, Maurizio

2015-03-01

Male-based studies, both at the biochemical and at the pre-clinical/clinical trial levels, still predominate in the scientific community. Many studies are based on the wrong assumption that both sexes are fundamentally identical in their response to treatments. As a result, findings obtained mainly in males are applied to females, resulting in negative consequences female patients. In cancer immunotherapy, there is still a scarce focus on this topic. Here we review the main differences in immune modulation and immune system biology between males and females with a particular focus on how these differences affect cancer immunotherapy and cancer vaccines. We reviewed articles published on PubMed from 1999 to 2014, using the keywords: sex hormones, immune response, estrogen, immunotherapy, testosterone, cancer vaccines, sex-based medicine. We also present new data wherein the expression of the cancer testis antigen, Ropporin-1, was determined in patients with multiple myeloma, showing that the expression of Ropporin-1 was influenced by sex. Male and female immune systems display radical differences mainly due to the immune regulatory effects of sex hormones. These differences might have a dramatic impact on the immunological treatment of cancer. Moreover, the expression of tumor antigens that can be targeted by anti-cancer vaccines is associated with sex. Future clinical trials focusing on cancer immunotherapy will need to take into account the differences in the immune response and in the frequency of target antigen expression between male and females, in order to optimize these anti-cancer immunotherapies of the third millennium.

Travel-acquired ESBL-producing Enterobacteriaceae: impact of colonization at individual and community level.

PubMed

Woerther, Paul-Louis; Andremont, Antoine; Kantele, Anu

2017-04-01

Antibiotic resistance is a rapidly increasing global emergency that calls for action from all of society. Intestinal multidrugresistant (MDR) bacteria have spread worldwide with extended-spectrum beta-lactamase (ESBL) -producing Enterobacteriaceae (ESBL-PE) as the most prevalent type. The millions of travelers annually visiting regions with poor hygiene contribute substantially to this spread. Our review explores the underlying data and discusses the consequences of the colonization. PubMed was searched for relevant literature between January 2010 and August 2016. We focused on articles reporting (1) the rate of ESBL-PE acquisition in a group of travelers recruited before/after international travel, (2) fecal carriage of ESBL-PE as explored by culture and, for part of the studies, (3) analysis of factors predisposing to colonization. We reviewed a total of 16 studies focusing on travel-acquired ESBL-PE. The acquisition rates reveal that 2070% of visitors to (sub)tropical regions get colonized by ESBL-PE. The main risk factors predisposing to colonization during travel are destination, travelers diarrhea, and antibiotic use. While most of those colonized remain asymptomatic, acquisition of ESBL-PE may have consequences both at individual and community level. We discuss current efforts to restrict the spread. © International Society of Travel Medicine, 2017. Published by Oxford University Press.

[Technostress in Communication and Technology Society: Scoping Literature Review from the Web of Science].

PubMed

Cuervo Carabel, Tatiana; Orviz Martínez, Natalia; Arce García, Sergio; Fernández Suárez, Iván

To perform a scoping review on the state of the art of technostress, an emerging risks associated with the growing use of Information and Communication Technologies (ICT) in society. a scoping review on technostress at work was performed using the Web of Science (WoS), using the key term "technostress work". The search was completed with a literature review of the selected articles. A total of 58 articles were identified, of which 30 were selected for full-text in-depth review. The manual search of the bibliography allowed us to analyze an additional 14 articles. Most of articles focus on the analysis on the precipitating and alleviating factors of technostress in workers, as well as the main consequences of the materialization of this risk on worker performance. There is a lack of empirical studies that allow organizations to establish strategies to adequately manage technostress. there is a need to delve further into technostress through empirical studies that are not only focused on proposing theoretical models for its conceptualization or identifying its consequences in organizations, but on proposing management strategies that reduce the impact of this new labor reality. Future lines of research are proposed to understand and adequately manage technostress in workers. Copyright belongs to the Societat Catalana de Salut Laboral.

Travel-acquired ESBL-producing Enterobacteriaceae: impact of colonization at individual and community level

PubMed Central

Woerther, Paul-Louis; Andremont, Antoine

2017-01-01

Abstract Background: Antibiotic resistance is a rapidly increasing global emergency that calls for action from all of society. Intestinal multidrugresistant (MDR) bacteria have spread worldwide with extended-spectrum beta-lactamase (ESBL) -producing Enterobacteriaceae (ESBL-PE) as the most prevalent type. The millions of travelers annually visiting regions with poor hygiene contribute substantially to this spread. Our review explores the underlying data and discusses the consequences of the colonization. Methods: PubMed was searched for relevant literature between January 2010 and August 2016. We focused on articles reporting (1) the rate of ESBL-PE acquisition in a group of travelers recruited before/after international travel, (2) fecal carriage of ESBL-PE as explored by culture and, for part of the studies, (3) analysis of factors predisposing to colonization. Results: We reviewed a total of 16 studies focusing on travel-acquired ESBL-PE. The acquisition rates reveal that 2070% of visitors to (sub)tropical regions get colonized by ESBL-PE. The main risk factors predisposing to colonization during travel are destination, travelers diarrhea, and antibiotic use. Conclusions: While most of those colonized remain asymptomatic, acquisition of ESBL-PE may have consequences both at individual and community level. We discuss current efforts to restrict the spread. PMID:28520999

Monolithic hybrid optics for focusing ultrashort laser pulses

NASA Astrophysics Data System (ADS)

Fuchs, U.

2014-03-01

Almost any application of ultrashort laser pulses involves focusing them in order to reach high intensities and/or small spot sizes as needed for micro-machining or Femto-LASIK. Hence, it is indispensable to be able to understand pulse front distortion caused by real world optics. Focusing causes pulse front distortion due to aberrations, dispersion and diffraction. Thus, the spatio-temporal profile of ultrashort laser is altered, which increases automatically the pulse duration and the focusing spot. Consequently, the main advantage of having ultrashort laser pulses - pulse durations way below 100 fs - can be lost in that one last step of the experimental set-up by focusing them unfavorable. Since compensating for dispersion, aberration and diffraction effects is quite complicated and not always possible, we pursue a different approach. We present a specially designed monolithic hybrid optics comprising refraction and diffraction effects for tight spatial and temporal focusing of ultrashort laser pulses. Both aims can be put into practice by having a high numerical aperture (NA = 0.35) and low internal dispersion at the same time. The focusing properties are very promising, due to a design, which provides diffraction limited focusing for 100 nm bandwidth at 780 nm center wavelength. Thus, pulses with durations as short as 10 fs can be focused without pulse front distortion. The outstanding performance of this optics is shown in theory and experimentally. Above that, such focusing optics are easily adapted to their special purpose - changing the center wavelength, achromatic bandwidth or even correcting for focusing into material is possible.

Consequences of maternal morbidity on health-related functioning: a systematic scoping review

PubMed Central

Machiyama, Kazuyo; Hirose, Atsumi; Cresswell, Jenny A; Barreix, Maria; Chou, Doris; Kostanjsek, Nenad; Say, Lale; Filippi, Véronique

2017-01-01

Objectives To assess the scope of the published literature on the consequences of maternal morbidity on health-related functioning at the global level and identify key substantive findings as well as research and methodological gaps. Methods We searched for articles published between 2005 and 2014 using Medline, Embase, Popline, CINAHL Plus and three regional bibliographic databases in January 2015. Design Systematic scoping review Primary outcome Health-related functioning Results After screening 17 706 studies, 136 articles were identified for inclusion. While a substantial number of papers have documented mostly negative effects of morbidity on health-related functioning and well-being, the body of evidence is not spread evenly across conditions, domains or geographical regions. Over 60% of the studies focus on indirect conditions such as depression, diabetes and incontinence. Health-related functioning is often assessed by instruments designed for the general population including the 36-item Short Form or disease-specific tools. The functioning domains most frequently documented are physical and mental; studies that examined physical, mental, social, economic and specifically focused on marital, maternal and sexual functioning are rare. Only 16 studies were conducted in Africa. Conclusions Many assessments have not been comprehensive and have paid little attention to important functioning domains for pregnant and postpartum women. The development of a comprehensive instrument specific to maternal health would greatly advance our understanding of burden of ill health associated with maternal morbidity and help set priorities. The lack of attention to consequences on functioning associated with the main direct obstetric complications is of particular concern. Review registration CRD42015017774 PMID:28667198

Design of New Power Management Circuit for Light Energy Harvesting System

PubMed Central

Jafer, Issa; Stack, Paul; MacNamee, Kevin

2016-01-01

Nowadays, it can be observed that Wireless Sensors Networks (WSN) are taking increasingly vital roles in many applications, such as building energy monitoring and control, which is the focus of the work in this paper. However, the main challenging issue with adopting WSN technology is the use of power sources such as batteries, which have a limited lifetime. A smart solution that could tackle this problem is using Energy Harvesting technology. The work in this paper will be focused on proposing a new power management design through harvesting indoor light intensity. The new approach is inspired by the use of the Fractional Open Circuit Voltage based Maximum Power Point tracking (MPPT) concept for sub mw Photo Voltaic (PV) cells. The new design adopts two main features: First, it minimizes the power consumed by the power management section; and second, it maximizes the MPPT-converted output voltage and consequently improves the efficiency of the power conversion in the sub mw power level. The new experimentally-tested design showed an improvement of 81% in the efficiency of MPPT conversion using 0.5 mW input power in comparison with the other presented solutions that showed less efficiency with higher input power. PMID:26907300

Potential unintended consequences of smoke-free policies in public places on pregnant women in China.

PubMed

Yao, Tingting; Lee, Anita H; Mao, Zhengzhong

2009-08-01

Smoke-free policies in public places have become more common in China. Little is known, however, about the potential unintended consequences of such policies on pregnant women. The study was conducted in 2006 in Chengdu, China. Nonsmoking pregnant women (N=55) whose husband were smokers participated in a study of their knowledge about secondhand smoke and smoke-free policies, their exposure to secondhand smoke, and their husbands' smoking status at home. This study presents descriptive statistics, analyses based on family income and pregnant women's education level, and the findings of focus group discussions that examined the potential unintended consequences of the smoke-free policies on pregnant women. Exposure to secondhand smoke at home was reported by 69.1% of the pregnant women. Both family income and the education level of the pregnant women had a significant (p<0.05) association with exposure to secondhand smoke. The four main potential unintended consequences of the smoke-free policies were: (1) increased exposure of pregnant women to secondhand smoke at home; (2) reduced work efficiency; (3) adverse effect on family harmony; and (4) poor air quality at home. Education is needed to increase knowledge of secondhand smoke among smokers and nonsmokers alike. When the smoking location is shifted from public places and workplaces to home, women, and in particular pregnant women, become the victims. Policymakers should recognize such potential unintended consequences and take necessary measures to increase awareness about the harms of secondhand smoke.

Health-related impact on quality of life and coping strategies for chikungunya: A qualitative study in Curaçao

PubMed Central

Grobusch, Martin P.; Tami, Adriana; Gerstenbluth, Izzy; Bailey, Ajay

2017-01-01

Introduction Chikungunya is an emerging public health problem in tropical and subtropical regions, due to ongoing transmission and its incapacitating acute disease phase, and chronic sequelae. The disease is responsible for a major impact on Health Related Quality of Life (HRQoL), which may last several years. To our knowledge, this study is the first qualitative examination of HRQoL and coping strategies of chikungunya-infected individuals. Methods Qualitative research methods consisted of 20 in-depth interviews and seven Focus Group Discussions (FGDs), n = 50. Analysis was based on the principles of the grounded theory. Results Different impacts on HRQoL were reported. The physical and emotional domains of the HRQoL were mainly affected by chikungunya, while social and individual financial consequences were limited. Individual financial impact was limited through the universal health care program of Curaçao. Long-term lingering musculoskeletal and other manifestations caused significant pain and limited mobility. Hence, participants experienced dependency, impairment of normal daily life activities, moodiness, hopelessness, a change of identity, and insecurity about their future. The unpredictable nature and consequences of chikungunya gave rise to various coping strategies. Problem-focused coping styles led to higher uptake of medical care and were linked to more negative impact of HRQoL, whereas emotional coping strategies focusing on acceptance of the situation were linked to less uptake of medical care and more positive impact on HRQoL. Conclusions This study provides an in-depth understanding of acute and long-term HRQoL impact of chikungunya. The results can better inform health promotion policies and interventions. Messages to the public should focus on promoting healthy and efficient coping strategies, in order to prevent additional stress in affected individuals. PMID:28991920

Individual consequences of having work and family roles simultaneously in Iranian married women.

PubMed

Taghizadeh, Ziba; Ebadi, Abbas; Mohammadi, Eesa; Pourreza, Abolghasem; Kazemnejad, Anoshirvan; Bagherzadeh, Razieh

2017-01-01

Because of the paucity of studies about the consequences of women's work and family responsibilities in Iran, in the present study the authors used a qualitative approach to begin to provide in-depth answers to the following question: What are the consequences of having work and family responsibilities in Iranian married women? Data were obtained from 29 participants using individual in-depth interviews conducted with 17 participants in addition to two focus groups (n = 6 per group), all conducted in the second half of 2014. All of the participants were Iranian nationals, married, and held a full-time job outside the home. Five main themes were derived from the study: "promotion of self-esteem and social status," "facing difficulties," "effort and dedication," "unfulfilled needs and non-optimal health," and "restless mind." Participants reported achieving a number of advantages for themselves and their families as a result of working outside the home; but, they also had many problems with the potential to impair various health aspects, including physical, reproductive, and mental health. Thus, it is important for Iranian health-care providers to consider the effect of the work-family interference on women.

[Consequences of collective violence with special focus on gender perspective].

PubMed

Helweg-Larsen, Karin; Kastrup, Marianne C

2006-09-04

There is increasing focus on the gender perspective related to the consequences of collective violence. Women run a greater risk of being victims of sexual violence, but few studies have focused on gender differences with respect to physical violence, sexual violations and the impact on health. Further research is needed on these issues as well as research on the identification of evidence based interventions.

Hyperammonemia in children: on the crossroad of different disorders.

PubMed

Paprocka, Justyna; Jamroz, Ewa

2012-09-01

Symptoms of hyperammonemia occur in patients irrespective of the kind of metabolic diseases. Age, metabolic and nutritional status, and decompensation factors such as infections influence clinical manifestations. Prolonged, untreated hyperammonemia leads to brain injury and intellectual disability. Treatment is directed at lowering plasma ammonia. Brain ammonium concentrations are 1.5 to 3.0 times higher than that in blood. The authors discuss the pathophysiology of the symptoms and consequences of hyperammonemia in children, focusing on the metabolic disorders leading to an increased level of ammonia. Ammonia toxicity has been investigated for a long time. According to the main hypotheses, the neurological alterations are connected to alterations in glutamatergic neurotransmission.

McStas-model of the delft SESANS

NASA Astrophysics Data System (ADS)

Knudsen, E.; Udby, L.; Willendrup, P. K.; Lefmann, K.; Bouwman, W. G.

2011-06-01

We present simulation results taking first virtual data from a model of the Spin-Echo Small Angle Scattering (SESANS) instrument situated in Delft, in the framework of the McStas Monte Carlo software package. The main focus has been on making a model of the Delft SESANS instrument, and we can now present the first virtual data from it, using a refracting prism-like sample model. In consequence, polarisation instrumentation is now included natively in the McStas kernel, including options for magnetic fields and a number of utility components. This development has brought us to a point where realistic models of polarisation-enabled instrumentation can be built.

Nanostructured Electrocatalysts for All-Vanadium Redox Flow Batteries.

PubMed

Park, Minjoon; Ryu, Jaechan; Cho, Jaephil

2015-10-01

Vanadium redox reactions have been considered as a key factor affecting the energy efficiency of the all-vanadium redox flow batteries (VRFBs). This redox reaction determines the reaction kinetics of whole cells. However, poor kinetic reversibility and catalytic activity towards the V(2+)/V(3+) and VO(2+)/VO2(+) redox couples on the commonly used carbon substrate limit broader applications of VRFBs. Consequently, modified carbon substrates have been extensively investigated to improve vanadium redox reactions. In this Focus Review, recent progress on metal- and carbon-based nanomaterials as an electrocatalyst for VRFBs is discussed in detail, without the intention to provide a comprehensive review on the whole components of the system. Instead, the focus is mainly placed on the redox chemistry of vanadium ions at a surface of various metals, different dimensional carbons, nitrogen-doped carbon nanostructures, and metal-carbon composites. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Anthropogenic impacts on tropical forest biodiversity: a network structure and ecosystem functioning perspective

PubMed Central

Morris, Rebecca J.

2010-01-01

Huge areas of diverse tropical forest are lost or degraded every year with dramatic consequences for biodiversity. Deforestation and fragmentation, over-exploitation, invasive species and climate change are the main drivers of tropical forest biodiversity loss. Most studies investigating these threats have focused on changes in species richness or species diversity. However, if we are to understand the absolute and long-term effects of anthropogenic impacts on tropical forests, we should also consider the interactions between species, how those species are organized in networks, and the function that those species perform. I discuss our current knowledge of network structure and ecosystem functioning, highlighting empirical examples of their response to anthropogenic impacts. I consider the future prospects for tropical forest biodiversity, focusing on biodiversity and ecosystem functioning in secondary forest. Finally, I propose directions for future research to help us better understand the effects of anthropogenic impacts on tropical forest biodiversity. PMID:20980318

The rationale for liquid biopsy in colorectal cancer: a focus on circulating tumor cells.

PubMed

Gazzaniga, Paola; Raimondi, Cristina; Nicolazzo, Chiara; Carletti, Raffaella; di Gioia, Cira; Gradilone, Angela; Cortesi, Enrico

2015-01-01

Capturing circulating tumor cells (CTCs) and/or circulating tumor DNA from blood, which represents a precious source of biological material derived from both primary and metastatic tumors, has been named a 'liquid biopsy'. While the circulating tumor DNA might be more representative of the bulk of the metastatic tumor, CTCs are thought to reflect more of the metastases-initiating cells. Consequently, a liquid biopsy made of tumor cells and tumor DNA that is able to track cancer evolution, as a fingerprint of the patient's individual tumor, and is easy to perform at every stage of the disease course, sounds attractive. This article mainly focuses on the applications of CTCs to track tumor dynamics in real time using colorectal cancer as a model system. The analysis of viable CTCs at DNA, RNA and protein levels, as well as their expansion in vitro, may allow deep investigation of the features of metastases-initiating cells.

[Progress in research of the mechanisms related with the hepatic steatosis in the nonalcoholic fatty liver disease].

PubMed

Shi, Li-Juan; Song, Guang-Yao

2013-12-01

With the increased morbidity of Nonalcoholic fatty liver disease, the pathogenesis of which has become one of the focuses for researchers. Many details need to be clarified. The hepatic steatosis has been taken as the clinical pathological characters and the "golden standard of diagnosis" for the nonalcoholic fatty liver disease. More and more studies have shown that the hepatic steatosis (mainly as triglycerides) is the consequence of hepatic lipid metabolism disequilibrium. Generally, the related metabolism pathways including lipid input, lipid uptake, de novo lipogenesis, fatty acid oxidation, fatty acid reesterification, and lipid secretion etc. In this review, we focused on the progress of some key enzymes involved in these pathways in order to clarify the possible molecular mechanisms and the effective targets so that to broad our vision about the prevention and treatment of non-alcoholic fatty liver disease.

Patterns in Students' Argumentation Confronted with a Risk-focused Socio-scientific Issue

NASA Astrophysics Data System (ADS)

Kolstø, Stein Dankert

2006-11-01

This paper reports a qualitative study on students’ informal reasoning on a controversial socio-scientific issue. Twenty-two students from four science classes in Norway were interviewed about the local construction of new power lines and the possible increased risk of childhood leukaemia. The focus in the study is on what arguments the students employ when asked about their decision-making and the interplay between knowledge and personal values. Five different types of main arguments are identified: the relative risk argument, the precautionary argument, the uncertainty argument, the small risk argument, and the pros and cons argument. These arguments are presented through case studies, and crucial information and values are identified for each argument. The students made use of a range of both scientific and non-scientific knowledge. The findings are discussed in relation to possible consequences for teaching models aimed at increasing students’ ability to make thoughtful decisions on socio-scientific issues.

Agronomic and remedial benefits and risks of applying biochar to soil: Current knowledge and future research directions.

PubMed

Kuppusamy, Saranya; Thavamani, Palanisami; Megharaj, Mallavarapu; Venkateswarlu, Kadiyala; Naidu, Ravi

2016-02-01

'Biochar' represents an emerging technology that is increasingly being recognized for its potential role in carbon sequestration, reducing greenhouse gas emissions, waste management, renewable energy, soil improvement, crop productivity enhancement and environmental remediation. Published reviews have so far focused mainly on the above listed agronomic and environmental benefits of applying biochar, yet paid little or no attention to its harmful effects on the ecological system. This review highlights a balanced overview of the advantages and disadvantages of the pyrolysis process of biochar production, end-product quality and the benefits versus drawbacks of biochar on: (a) soil geochemistry and albedo, (b) microflora and fauna, (c) agrochemicals, (d) greenhouse gas efflux, (e) nutrients, (f) crop yield, and (g) contaminants (organic and inorganic). Future research should focus more on the unintended long-term consequences of biochar on biological organisms and their processes in the soil. Copyright © 2015 Elsevier Ltd. All rights reserved.

Cognitive behavioral approach to understanding irritable bowel syndrome

PubMed Central

Hauser, Goran; Pletikosic, Sanda; Tkalcic, Mladenka

2014-01-01

Irritable bowel syndrome (IBS) is considered a biopsychosocial disorder, whose onset and precipitation are a consequence of interaction among multiple factors which include motility disturbances, abnormalities of gastrointestinal sensation, gut inflammation and infection, altered processing of afferent sensory information, psychological distress, and affective disturbances. Several models have been proposed in order to describe and explain IBS, each of them focusing on specific aspects or mechanisms of the disorder. This review attempts to present and discuss different determinants of IBS and its symptoms, from a cognitive behavioral therapy framework, distinguishing between the developmental predispositions and precipitants of the disorder, and its perpetuating cognitive, behavioral, affective and physiological factors. The main focus in understanding IBS will be placed on the numerous psychosocial factors, such as personality traits, early experiences, affective disturbances, altered attention and cognitions, avoidance behavior, stress, coping and social support. In conclusion, a symptom perpetuation model is proposed. PMID:24944466

Serum Magnesium after Kidney Transplantation: A Systematic Review.

PubMed

Garnier, Anne-Sophie; Duveau, Agnès; Planchais, Martin; Subra, Jean-François; Sayegh, Johnny; Augusto, Jean-François

2018-06-06

Magnesium (Mg) status has recently drawn close attention in chronic kidney disease and in kidney transplant recipients. This review aims to evaluate the body of evidence linking hypomagnesemia to clinical consequences in these specific populations. After a brief summary of the main mechanisms involved in Mg regulation and of Mg status in end-stage renal disease, the review focuses on the relationship between hypomagnesemia and cardiovascular risk in kidney transplant recipients. A body of evidence in recent studies points to a negative impact of hypomagnesemia on post-transplant diabetes mellitus (PTDM) and cardiovascular risk, which currently represent the main threat for morbidity and mortality in kidney transplantation. Deleterious biological mechanisms induced by hypomagnesemia are also discussed. While data analysis enables us to conclude that hypomagnesemia is linked to the development of PTDM, studies prospectively evaluating the impact of hypomagnesemia correction after kidney transplantation are still lacking and needed.

Social problems and health in urbanization.

PubMed

Talib, R; Agus, M R

1992-01-01

One of the main characteristics of urbanization in Asia is the very rapid increase in population movement from rural to urban centers. This phenomenon has led to changing population structure, its composition and lifestyles in the cities and its fringes. As a consequent of population pressure on urban system and infrastructure, compounded by the nature of the composition of the in-migrant population, the urban concentrates are faced with several social and socio-economic problems. Although there has been a lot of interests among researchers to study the causes and effects or urbanization, there is a vacuum in the area of health implications. Planners and administrators usually give priority to the physical aspects of the urban and urbanities. Social problems and health implications thereof receives very little attention either at the level of administration or research. This paper therefore is a brave attempt to focus and draw some attention to this neglected area by looking at selected social problems and the health consequences.

Consequences of Arizona's Immigration Policy on Social Capital among Mexican Mothers with Unauthorized Immigration Status

ERIC Educational Resources Information Center

Valdez, Carmen R.; Padilla, Brian; Valentine, Jessa Lewis

2013-01-01

This study explores the consequences of increasingly restrictive immigration policies on social capital among Mexican mothers with unauthorized immigrant status in Arizona. Three focus groups conducted in Arizona explore how mothers' experiences with immigration policies have affected their neighborhood, community, and family ties. Focus group…

Economic impact profiling of CBRN events: focusing on biological incidents.

PubMed

Cavallini, Simona; Bisogni, Fabio; Mastroianni, Marco

2014-12-01

Chemical, biological, radiological and nuclear (CBRN) incidents, both caused accidentally by human error or natural/technological events and determined intentionally as criminal/malicious/terroristic acts, have consequences that could be differently characterized. In the last years many efforts to analyze the economic impact of terrorist threat have been carried out, while researches specifically concerning CBRN events have not been extensively undertaken. This paper in particular aims at proposing a methodological approach for studying macro-level economic impact profiles of biological incidents caused by weaponized and non-weaponized materials. The suggested approach investigates the economic consequences of biological incidents according to two main dimensions: type of large-scale effect and persistence of effect. Biological incident economic impacts are analyzed taking into account the persistence of effect during time as short-term impact (i.e. immediately after the incident), medium-term impact (i.e. by a month) and long-term impact (i.e. by years). The costs due to preventive countermeasure against biological threats (e.g. prevention, protection and preparedness expenses) are not taken into account. To this purpose, information on the key features of past biological incidents can be used as case studies to try to build impact profiles taking into account the proposed two main dimensions. Consequence management and effect mitigation of CBRN emergencies and disasters may benefit from an ex ante definition of the impact profiling related to this kind of incidents. The final goal of this paper is to define an approach to organize information on possible biological events according to their impact profile for supporting more effective and efficient first responders' prompt actions and policy makers' strategic decisions after the event occurrence.

Risk-targeted maps for Romania

NASA Astrophysics Data System (ADS)

Vacareanu, Radu; Pavel, Florin; Craciun, Ionut; Coliba, Veronica; Arion, Cristian; Aldea, Alexandru; Neagu, Cristian

2018-03-01

Romania has one of the highest seismic hazard levels in Europe. The seismic hazard is due to a combination of local crustal seismic sources, situated mainly in the western part of the country and the Vrancea intermediate-depth seismic source, which can be found at the bend of the Carpathian Mountains. Recent seismic hazard studies have shown that there are consistent differences between the slopes of the seismic hazard curves for sites situated in the fore-arc and back-arc of the Carpathian Mountains. Consequently, in this study we extend this finding to the evaluation of the probability of collapse of buildings and finally to the development of uniform risk-targeted maps. The main advantage of uniform risk approach is that the target probability of collapse will be uniform throughout the country. Finally, the results obtained are discussed in the light of a recent study with the same focus performed at European level using the hazard data from SHARE project. The analyses performed in this study have pointed out to a dominant influence of the quantile of peak ground acceleration used for anchoring the fragility function. This parameter basically alters the shape of the risk-targeted maps shifting the areas which have higher collapse probabilities from eastern Romania to western Romania, as its exceedance probability increases. Consequently, a uniform procedure for deriving risk-targeted maps appears as more than necessary.

Consequences of Moral Distress in the Intensive Care Unit: A Qualitative Study.

PubMed

Henrich, Natalie J; Dodek, Peter M; Gladstone, Emilie; Alden, Lynn; Keenan, Sean P; Reynolds, Steven; Rodney, Patricia

2017-07-01

Moral distress is common among personnel in the intensive care unit, but the consequences of this distress are not well characterized. To examine the consequences of moral distress in personnel in community and tertiary intensive care units in Vancouver, Canada. Data for this study were obtained from focus groups and analysis of transcripts by themes and sub-themes in 2 tertiary care intensive care units and 1 community intensive care unit. According to input from 19 staff nurses (3 focus groups), 4 clinical nurse leaders (1 focus group), 13 physicians (3 focus groups), and 20 other health professionals (3 focus groups), the most commonly reported emotion associated with moral distress was frustration. Negative impact on patient care due to moral distress was reported 26 times, whereas positive impact on patient care was reported 11 times and no impact on patient care was reported 10 times. Having thoughts about quitting working in the ICU was reported 16 times, and having no thoughts about quitting was reported 14 times. In response to moral distress, health care providers experience negative emotional consequences, patient care is perceived to be negatively affected, and nurses and other health care professionals are prone to consider quitting working in the intensive care unit. ©2017 American Association of Critical-Care Nurses.

Constructive and Unconstructive Repetitive Thought

PubMed Central

Watkins, Edward R.

2008-01-01

The author reviews research showing that repetitive thought (RT) can have constructive or unconstructive consequences. The main unconstructive consequences of RT are (a) depression, (b) anxiety, and (c) difficulties in physical health. The main constructive consequences of RT are (a) recovery from upsetting and traumatic events, (b) adaptive preparation and anticipatory planning, (c) recovery from depression, and (d) uptake of health-promoting behaviors. Several potential principles accounting for these distinct consequences of RT are identified within this review: (a) the valence of thought content, (b) the intrapersonal and situational context in which RT occurs, and (c) the level of construal (abstract vs. concrete processing) adopted during RT. Of the existing models of RT, it is proposed that an elaborated version of the control theory account provides the best theoretical framework to account for its distinct consequences. PMID:18298268

Behavior of pyrophite shrubs in mediterranean terrestrial ecosystems (i): Population and reproductive model.

PubMed

Usó-Doménech, Josep-Lluis; Nescolarde-Selva, Josué-Antonio; Lloret-Climent, Miguel; González-Franco, Lucía

2018-03-01

The mathematical submodel ULEX is used to study the dynamic behavior of the green, floral and woody biomass of the main pyrophite shrub species, the gorse (Ulex parviflorus Pourret), and its relationship with other shrub species, typical of a Mediterranean ecosystem. The focus are the ecological conditions of post-fire stage growth, and its efficacy as a protective cover against erosion processes in the short, medium and long term, both in normal conditions and at the limits of desertification conditions. The model sets a target to observe the behavior and to anticipate and consequently intervene with adequate protection, restoration and management measures. Copyright © 2018 Elsevier Inc. All rights reserved.

Virtual rehabilitation: What are the practical barriers for home-based research?

PubMed Central

Threapleton, Kate; Drummond, Avril; Standen, Penny

2016-01-01

Virtual reality technologies are becoming increasingly accessible and affordable to deliver, and consequently the interest in applying virtual reality within rehabilitation is growing. This has resulted in the emergence of research exploring the utility of virtual reality and interactive video gaming interventions for home use by patients. The aim of this paper is to highlight the practical factors and difficulties that may be encountered in research in this area, and to make recommendations for addressing these. Whilst this paper focuses on examples drawn mainly from stroke rehabilitation research, many of the issues raised are relevant to other conditions where virtual reality approaches have the potential to be applied to home-based rehabilitation. PMID:29942551

Noiseless optical amplification in quasi-phase-matched bulk lithium niobate

NASA Astrophysics Data System (ADS)

Lovering, D. J.; Levenson, J. A.; Vidakovic, P.; Webjörn, J.; Russell, P. St. J.

1996-09-01

An optical parametric amplifier (OPA) has been demonstrated in bulk, periodically poled lithium niobate and is shown to operate with a noise figure well below the classical limit. In contrast to conventional OPA's, this device uses quasi-phase matching to provide the coupling between the pump and the signal. Comparison of the measured performance with that of a theoretical model reveals that the main intrinsic contribution to the output noise is due to spatial and temporal mode mixing, which arises as a consequence of tight focusing of the incident beams. Factors that affect the performance of this amplifier are identified theoretically and their relative importance investigated for both amplification and squeezing.

The blues broaden, but the nasty narrows: attentional consequences of negative affects low and high in motivational intensity.

PubMed

Gable, Philip; Harmon-Jones, Eddie

2010-02-01

Positive and negative affects high in motivational intensity cause a narrowing of attentional focus. In contrast, positive affects low in motivational intensity cause a broadening of attentional focus. The attentional consequences of negative affects low in motivational intensity have not been experimentally investigated. Experiment 1 compared the attentional consequences of negative affect low in motivational intensity (sadness) relative to a neutral affective state. Results indicated that low-motivation negative affect caused attentional broadening. Experiment 2 found that disgust, a high-motivation negative affect not previously investigated in attentional studies, narrowed attentional focus. These experiments support the conceptual model linking high-motivation affective states to narrowed attention and low-motivation affective states to broadened attention.

Anticipating the Social Consequences of AIDS: A Position Paper.

ERIC Educational Resources Information Center

Berk, Richard A.; And Others

1981-01-01

Focuses on the social consequences of the AIDS epidemic, arguing that sociologists have an important contribution to make in planning for the long-range social consequences of AIDS. Concludes with three different commentaries on Berk's article. (Author/BSR)

Information technology and ethics: An exploratory factor analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Conger, S.; Loch, K.D.; Helft, B.L.

1994-12-31

Ethical dilemmas are situations in which a decision results in unpleasant consequences. The unpleasant consequences are treated as a zero-sum game in which someone always loses. Introducing information technology (IT) to a situation makes the recognition of a potential loser more abstract and difficult to identify, thus an ethical dilemma may go unrecognized. The computer mediates the human relationship which causes a lost sense of contact with a person at the other end of the computer connection. In 1986, Richard O. Mason published an essay identifying privacy, accuracy, property, and Access (PAPA) as the four main ethical issues of themore » information age. Anecdotes for each issue describe the injured party`s perspective to identify consequences resulting from unethical use of information and information technology. This research sought to validate Mason`s social issues empirically, but with distinct differences. Mason defined issues to raise awareness and initiate debate on the need for a social agenda; our focus is on individual computer users and the attitudes they hold about ethical behavior in computer use. This study examined the attitudes of the computer user who experiences the ethical dilemma to determine the extent to which ethical components are recognized, and whether Mason`s issues form recognizable constructs.« less

Balancing measures or a balanced accounting of improvement impact: a qualitative analysis of individual and focus group interviews with improvement experts in Scotland.

PubMed

Toma, Madalina; Dreischulte, Tobias; Gray, Nicola M; Campbell, Diane; Guthrie, Bruce

2018-07-01

As quality improvement (QI) programmes have become progressively larger scale, the risks of implementation having unintended consequences are increasingly recognised. More routine use of balancing measures to monitor unintended consequences has been proposed to evaluate overall effectiveness, but in practice published improvement interventions hardly ever report identification or measurement of consequences other than intended goals of improvement. We conducted 15 semistructured interviews and two focus groups with 24 improvement experts to explore the current understanding of balancing measures in QI and inform a more balanced accounting of the overall impact of improvement interventions. Data were analysed iteratively using the framework approach. Participants described the consequences of improvement in terms of desirability/undesirability and the extent to which they were expected/unexpected when planning improvement. Four types of consequences were defined: expected desirable consequences ( goals ); expected undesirable consequences ( trade-offs ); unexpected undesirable consequences ( unpleasant surprises ); and unexpected desirable consequences ( pleasant surprises ). Unexpected consequences were considered important but rarely measured in existing programmes, and an improvement pause to take stock after implementation would allow these to be more actively identified and managed. A balanced accounting of all consequences of improvement interventions can facilitate staff engagement and reduce resistance to change, but has to be offset against the cost of additional data collection. Improvement measurement is usually focused on measuring intended goals , with minimal use of balancing measures which when used, typically monitor trade-offs expected before implementation. This paper proposes that improvers and leaders should seek a balanced accounting of all consequences of improvement across the life of an improvement programme, including deliberately pausing after implementation to identify and quantitatively or qualitatively evaluate any pleasant or unpleasant surprises. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Individual, interpersonal, and organisational factors of healthcare conflict: A scoping review.

PubMed

Kim, Sara; Bochatay, Naike; Relyea-Chew, Annemarie; Buttrick, Elizabeth; Amdahl, Chris; Kim, Laura; Frans, Elise; Mossanen, Matthew; Khandekar, Azhar; Fehr, Ryan; Lee, Young-Mee

2017-05-01

Unresolved conflicts among healthcare professionals can lead to difficult patient care consequences. This scoping review examines the current healthcare literature that reported sources and consequences of conflict associated with individual, interpersonal, and organisational factors. We identified 99 articles published between 2001 and 2015 from PubMed, Cumulative Index to Nursing and Allied Health Literature, and Excerpta Medical Database. Most reviewed studies relied on healthcare professionals' perceptions and beliefs associated with conflict sources and consequences, with few studies reporting behavioural or organisational change outcomes. Individual conflict sources included personal traits, such as self-focus, self-esteem, or worldview, as well as individuals' conflict management styles. These conflicts posed threats to one's physical, mental, and emotional health and to one's ability to perform at work. Interpersonal dynamics were hampered by colleagues' uncivil behaviours, such as low degree of support, to more destructive behaviours including bullying or humiliation. Perceptions of disrespectful working environment and weakened team collaboration were the main interpersonal conflict consequences. Organisational conflict sources included ambiguity in professional roles, scope of practice, reporting structure, or workflows, negatively affecting healthcare professionals' job satisfactions and intent to stay. Future inquiries into healthcare conflict research may target the following: shifting from research involving single professions to multiple professions; dissemination of studies via journals that promote interprofessional research; inquiries into the roles of unconscious or implicit bias, or psychological capital (i.e., resilience) in healthcare conflict; and diversification of data sources to include hospital or clinic data with implications for conflict sources.

The Altered Hepatic Tubulin Code in Alcoholic Liver Disease

PubMed Central

Groebner, Jennifer L.; Tuma, Pamela L.

2015-01-01

The molecular mechanisms that lead to the progression of alcoholic liver disease have been actively examined for decades. Because the hepatic microtubule cytoskeleton supports innumerable cellular processes, it has been the focus of many such mechanistic studies. It has long been appreciated that α-tubulin is a major target for modification by highly reactive ethanol metabolites and reactive oxygen species. It is also now apparent that alcohol exposure induces post-translational modifications that are part of the natural repertoire, mainly acetylation. In this review, the modifications of the “tubulin code” are described as well as those adducts by ethanol metabolites. The potential cellular consequences of microtubule modification are described with a focus on alcohol-induced defects in protein trafficking and enhanced steatosis. Possible mechanisms that can explain hepatic dysfunction are described and how this relates to the onset of liver injury is discussed. Finally, we propose that agents that alter the cellular acetylation state may represent a novel therapeutic strategy for treating liver disease. PMID:26393662

The Altered Hepatic Tubulin Code in Alcoholic Liver Disease.

PubMed

Groebner, Jennifer L; Tuma, Pamela L

2015-09-18

The molecular mechanisms that lead to the progression of alcoholic liver disease have been actively examined for decades. Because the hepatic microtubule cytoskeleton supports innumerable cellular processes, it has been the focus of many such mechanistic studies. It has long been appreciated that α-tubulin is a major target for modification by highly reactive ethanol metabolites and reactive oxygen species. It is also now apparent that alcohol exposure induces post-translational modifications that are part of the natural repertoire, mainly acetylation. In this review, the modifications of the "tubulin code" are described as well as those adducts by ethanol metabolites. The potential cellular consequences of microtubule modification are described with a focus on alcohol-induced defects in protein trafficking and enhanced steatosis. Possible mechanisms that can explain hepatic dysfunction are described and how this relates to the onset of liver injury is discussed. Finally, we propose that agents that alter the cellular acetylation state may represent a novel therapeutic strategy for treating liver disease.

Considerations on Dop (Depth Of Penetration) Test for Evaluation of Ceramics Materials Used in Ballistic Protection

NASA Astrophysics Data System (ADS)

Popa, Ioan-Dan; Dobriţa, Florin

2017-12-01

Tremendous amount of funds and other resorces were invested in studying the response of ceramic materials under ballistic impact, the main goal being to find a way to increase the protection of soldiers and the vehicles used in the modern battlespace. Using of ceramic materials especially carbon based (carbides), nitrogen based (nitrides) and oxygen based (oxides) ceramics in order to increase the protection level of ballistic equipment could be, sometimes, a big challenge when trying to use the proper test in order to evaluate and compare their performances. The role of the tests is to provide a better understanding of their response in different situations and, as a consequence, to make them more efficient as armour components through future improvements. The paper presents shortly the main tests which are used and eventually standardised for evaluating the ballistic behaviour of the ceramics and other armour components, with a special focus to DOP (Depth of Penetration) Tests.

[Leadership Experience of Clinical Nurses: Applying Focus Group Interviews].

PubMed

Lee, Byoung Sook; Eo, Yong Sook; Lee, Mi Aie

2015-10-01

The purpose of this study was to understand and describe the leadership experience of clinical nurses. During 2014, data were collected using focus group interviews. Three focus group interviews were held with a total of 20 clinical nurses participating. All interviews were recorded as they were spoken and transcribed and data were analyzed using qualitative content analysis. Fifteen categories emerged from the five main themes. 1) Thoughts on the leadership category: to lead others, to cope with problem situations adequately and to serve as a shield against difficulties. 2) Situations requiring leadership: situation that requires correct judgement, coping and situations that need coordination and cooperation. 3-1) Leadership behaviors: other-oriented approach and self-oriented approach. 3-2) Leadership behavior consequences: relevant compensation and unfair termination. 4-1) Facilitators of leadership: confidence and passion for nursing and external support and resources. 4-2) Barriers to leadership: non-supportive organization culture and deficiency in own leadership competencies. 5) Strategies of leadership development: strengthen leadership through self-development and organizational leadership development. In conclusion, the results indicate that it is necessary to enhance clinical nurses' leadership role in healthcare. Enhancement can be achieved through leadership programs focused on enlarging leadership experience, constant self-development, leadership training, and development of leadership competencies suited to the nursing environment.

Convinced, ambivalent or annoyed: Tyrolean ski tourism stakeholders and their perceptions of climate change.

PubMed

Trawöger, Lisa

2014-02-01

Its focus on snow-dependent activities makes Alpine winter tourism especially sensitive to climate change. Stakeholder risk perceptions are a key factor in adaptation to climate change because they fundamentally drive or constrain stakeholder action. This paper examines climate change perceptions of winter tourism stakeholders in Tyrol (Austria). Using a qualitative approach, expert interviews were conducted. Four opinion categories reflecting different attitudes toward climate change issues were identified: convinced planners , annoyed deniers , ambivalent optimists , convinced wait-and-seers . Although the findings generally indicate a growing awareness of climate change, this awareness is mainly limited to perceiving the issue as a global phenomenon. Awareness of regional and branch-specific consequences of climate change that lead to a demand for action could not be identified. Current technical strategies, like snowmaking, are not primarily climate-induced. At present, coping with climate change is not a priority for risk management. The findings point out the importance of gaining and transferring knowledge of regional and branch-specific consequences of climate change in order to induce action at the destination level.

Endocrine disruptors and other inhibitors of 11β-hydroxysteroid dehydrogenase 1 and 2: Tissue-specific consequences of enzyme inhibition.

PubMed

Vitku, Jana; Starka, Luboslav; Bicikova, Marie; Hill, Martin; Heracek, Jiri; Sosvorova, Lucie; Hampl, Richard

2016-01-01

Numerous chemicals in the environment have the ability to interact with the endocrine system. These compounds are called endocrine disruptors (EDs). Exposure to EDs represents one of the hypotheses for decreasing fertility, the increased risk of numerous cancers and obesity, metabolic syndrome and type 2 diabetes. There are various mechanisms of ED action, one of which is their interference in the action of 11β-hydroxysteroid dehydrogenase (11βHSD) that maintains a balance between active and inactive glucocorticoids on the intracellular level. This enzyme has two isoforms and is expressed in various tissues. Inhibition of 11βHSD in various tissues can have different consequences. In the case of EDs, the results of exposure are mainly adverse; on the other hand pharmaceutically developed inhibitors of 11βHSD type 1 are evaluated as an option for treating metabolic syndrome, as well as related diseases and depressive disorders. This review focuses on the effects of 11βHSD inhibitors in the testis, colon, adipose tissue, kidney, brain and placenta. Copyright © 2014 Elsevier Ltd. All rights reserved.

Cheyne-Stokes respiration in patients with congestive heart failure: causes and consequences.

PubMed

Lorenzi-Filho, Geraldo; Genta, Pedro R; Figueiredo, Adelaide C; Inoue, Daniel

2005-08-01

Cheyne-Stokes respiration is a form of periodic breathing in which central apneas and hypopneas alternate with periods of hyperventilation, producing a waxing and waning pattern of tidal volume. This review focuses on the causes and consequences of Cheyne-Stokes respiration in patients with congestive heart failure, in whom the prevalence is strikingly high and ranges from 30% to 50%. Several factors have been implicated in the genesis of Cheyne-Stokes respiration, including low cardiac output and recurrent hypoxia. The key pathophysiological mechanism triggering Cheyne-Stokes respiration is hyperventilation and low arterial CO2 (PaCO2) that when below the apneic threshold triggers a central apnea. Hyperventilation is associated with pulmonary congestion, and Cheyne-Stokes respiration is more prone to occur during sleep, when the respiratory system is mainly dependent on chemical control. It is associated with recurrent dips in oxygen saturation and arousals from sleep, with oscillations in blood pressure and heart rate, sympathetic activation and increased risk of ventricular tachycardia. Cheyne-Stokes respiration is an independent marker of poor prognosis and may participate in a vicious cycle, further stressing the failing heart.

Perceived stress at transition to workplace: a qualitative interview study exploring final-year medical students’ needs

PubMed Central

Moczko, Tobias R; Bugaj, Till J; Herzog, Wolfgang; Nikendei, Christoph

2016-01-01

Objectives This study was designed to explore final-year medical students’ stressors and coping strategies at the transition to the clinical workplace. Methods In this qualitative study, semi-standardized interviews with eight final-year medical students (five male, three female; aged 25.9±1.4 years) were conducted during their internal medicine rotation. After verbatim transcription, a qualitative content analysis of students’ impressions of stress provoking and easing factors during final-year education was performed. Results Students’ statements regarding burdens and dealing with stress were classified into four main categories: A) perceived stressors and provoking factors, B) stress-induced consequences, C) personal and external resources for preventing and dealing with stress, and D) final-year students’ suggestions for workplace improvement. Conclusion Final-year medical students perceived different types of stress during their transition to medical wards, and reported both negative consequences and coping resources concerning perceived stress. As supervision, feedback, and coping strategies played an important role in the students’ perception of stress, final-year medical education curricula development should focus on these specifically. PMID:26834503

Convinced, ambivalent or annoyed: Tyrolean ski tourism stakeholders and their perceptions of climate change☆

PubMed Central

Trawöger, Lisa

2014-01-01

Its focus on snow-dependent activities makes Alpine winter tourism especially sensitive to climate change. Stakeholder risk perceptions are a key factor in adaptation to climate change because they fundamentally drive or constrain stakeholder action. This paper examines climate change perceptions of winter tourism stakeholders in Tyrol (Austria). Using a qualitative approach, expert interviews were conducted. Four opinion categories reflecting different attitudes toward climate change issues were identified: convinced planners, annoyed deniers, ambivalent optimists, convinced wait-and-seers. Although the findings generally indicate a growing awareness of climate change, this awareness is mainly limited to perceiving the issue as a global phenomenon. Awareness of regional and branch-specific consequences of climate change that lead to a demand for action could not be identified. Current technical strategies, like snowmaking, are not primarily climate-induced. At present, coping with climate change is not a priority for risk management. The findings point out the importance of gaining and transferring knowledge of regional and branch-specific consequences of climate change in order to induce action at the destination level. PMID:27064520

Space-Time, Relativity, and Cosmology

NASA Astrophysics Data System (ADS)

Wudka, Jose

2006-07-01

Space-Time, Relativity and Cosmology provides a historical introduction to modern relativistic cosmology and traces its historical roots and evolution from antiquity to Einstein. The topics are presented in a non-mathematical manner, with the emphasis on the ideas that underlie each theory rather than their detailed quantitative consequences. A significant part of the book focuses on the Special and General theories of relativity. The tests and experimental evidence supporting the theories are explained together with their predictions and their confirmation. Other topics include a discussion of modern relativistic cosmology, the consequences of Hubble's observations leading to the Big Bang hypothesis, and an overview of the most exciting research topics in relativistic cosmology. This textbook is intended for introductory undergraduate courses on the foundations of modern physics. It is also accessible to advanced high school students, as well as non-science majors who are concerned with science issues.• Uses a historical perspective to describe the evolution of modern ideas about space and time • The main arguments are described using a completely non-mathematical approach • Ideal for physics undergraduates and high-school students, non-science majors and general readers

Smartphone-Based Solutions for Fall Detection and Prevention: Challenges and Open Issues

PubMed Central

Habib, Mohammad Ashfak; Mohktar, Mas S.; Kamaruzzaman, Shahrul Bahyah; Lim, Kheng Seang; Pin, Tan Maw; Ibrahim, Fatimah

2014-01-01

This paper presents a state-of-the-art survey of smartphone (SP)-based solutions for fall detection and prevention. Falls are considered as major health hazards for both the elderly and people with neurodegenerative diseases. To mitigate the adverse consequences of falling, a great deal of research has been conducted, mainly focused on two different approaches, namely, fall detection and fall prevention. Required hardware for both fall detection and prevention are also available in SPs. Consequently, researchers' interest in finding SP-based solutions has increased dramatically over recent years. To the best of our knowledge, there has been no published review on SP-based fall detection and prevention. Thus in this paper, we present the taxonomy for SP-based fall detection and prevention solutions and systematic comparisons of existing studies. We have also identified three challenges and three open issues for future research, after reviewing the existing articles. Our time series analysis demonstrates a trend towards the integration of external sensing units with SPs for improvement in usability of the systems. PMID:24759116

Persons with Epilepsy: Between Social Inclusion and Marginalisation

PubMed Central

Mlinar, Simona; Petek, Davorina; Cotič, Živa; Mencin Čeplak, Metka; Zaletel, Marjan

2016-01-01

Background. Epilepsy is a chronic neurological disorder that can lead to complex psychosocial consequences. Epilepsy can change the social status of persons with epilepsy (PWE) and has an effect on their social inclusion as well as their perception of social inclusion. This study aims to explore subjective experiences with social inclusion of PWE in Slovenia. Methods. This study takes a qualitative approach. Eleven semistructured interviews were conducted with eleven participants. Interviews were analysed using thematic analysis. Results. Epilepsy has physical, emotional, and social consequences. Physical consequences of epilepsy are mainly tiredness and exhaustion following an epileptic episode, frequently accompanied by headaches. Emotional consequences are different forms of fear. The main social consequence identified is a negative effect on PWE's social network, which leads to (self-)isolation and social distrust. Conclusion. PWE experience of social inclusion depends on various psychosocial factors and differs from person to person. The consequences of epilepsy are shown in PWE social contacts and their sense of social inclusion and autonomy. PMID:27212802

Persons with Epilepsy: Between Social Inclusion and Marginalisation.

PubMed

Mlinar, Simona; Petek, Davorina; Cotič, Živa; Mencin Čeplak, Metka; Zaletel, Marjan

2016-01-01

Epilepsy is a chronic neurological disorder that can lead to complex psychosocial consequences. Epilepsy can change the social status of persons with epilepsy (PWE) and has an effect on their social inclusion as well as their perception of social inclusion. This study aims to explore subjective experiences with social inclusion of PWE in Slovenia. This study takes a qualitative approach. Eleven semistructured interviews were conducted with eleven participants. Interviews were analysed using thematic analysis. Epilepsy has physical, emotional, and social consequences. Physical consequences of epilepsy are mainly tiredness and exhaustion following an epileptic episode, frequently accompanied by headaches. Emotional consequences are different forms of fear. The main social consequence identified is a negative effect on PWE's social network, which leads to (self-)isolation and social distrust. PWE experience of social inclusion depends on various psychosocial factors and differs from person to person. The consequences of epilepsy are shown in PWE social contacts and their sense of social inclusion and autonomy.

Homeland Biological Warfare Consequence Management: Capabilities and Needs Assessment

DTIC Science & Technology

2001-04-01

AU/ACSC/105/2001-04 AIR COMMAND AND STAFF COLLEGE AIR UNIVERSITY HOMELAND BIOLOGICAL WARFARE CONSEQUENCE MANAGEMENT: CAPABILITIES AND NEEDS...Dates Covered (from... to) - Title and Subtitle Homeland biological Warfare Consequence Management: Capabilities and Needs Assessment Contract...FEMA, DoJ, DoD, HHS, etc.) make a comprehensive, organized solution to the problem difficult. Focusing on the consequence management functions

Alzheimer's disease and the law: positive and negative consequences of structural stigma and labeling in the legal system.

PubMed

Werner, Perla; Doron, Israel Issi

2017-11-01

To explore the meaning and consequences of labeling on structural stigma in the context of Alzheimer's disease (AD) in the legal system. This qualitative study was made up of three focus groups including social workers and lawyers (n = 26). Participants were asked to report their experience in circumstances in which persons with AD and their family members engage with the legal system. Thematic analysis using the constant comparative method was used. The discussions in the focus groups raised two overall themes. (1) The significance of the medical diagnostic labeling of AD in the legal system and (2) the consequences of labeling of AD within the legal system. This last theme included four sub-themes: (a) negative consequences of labeling; (b) reasons associated with negative consequences of labeling; (c) positive consequences of labeling; and (d) reasons associated with positive consequences of labeling. Findings of the study provide a first foundation for future research on the meaning and consequences of labeling in legal cases involving persons with AD. They suggest that increasing judges' knowledge about AD and reforming the existing 'status-based' legal capacity legislation might benefit by limiting the legal weight given today to the medical diagnosis.

Domains of quality of life affecting elderly patients with hand osteoarthritis: a qualitative study in the Asian perspective.

PubMed

Thumboo, Julian; Wu, Li; Leung, Ying Ying

2017-09-01

Hand osteoarthritis (HOA) is common but little is known about how HOA has impact on disability and quality of life (QoL).We aim to identify important domains of concern among participants suffering from symptomatic HOA in Singapore, representing an Asian socio-cultural context. A qualitative study using a focus group technique was performed. We ran focus groups stratified by gender, ethnicity and language. Two independent, trained analysts identified relevant categories and assigned codes to text segments through open coding, with discrepancies resolved through consensus. The final lists of domains and subthemes descriptive of QoL were then compared to the following commonly used HOA specific instruments: Functional Index for Hand Osteoarthritis (FIHOA), Score for Assessment and quantification of Chronic Rheumatic Affections of the Hand (SACRAH), Australian/Canadian Hand Osteoarthritis Index (AUSCAN); and Health Assessment Questionnaire (HAQ). Twenty-six patients (23 women, three men; 24 Chinese and two Malay; mean ± SD age 62.9 ± 7.5 years) with symptomatic HOA according to the American College of Rheumatology Classification Criteria participated in seven focus groups. Two and five focus groups were conducted in Chinese and English, respectively. The qualitative analysis revealed pain, stiffness and functional disability as the main domains. However, psychological consequences, aesthetic concerns, participation in leisure activities, participation in family roles were important concepts from the focus groups which were not covered by existing instruments. Impact on work productivity by HOA and the unmet health care need is revealed. The domains of concepts important to people with HOA in an Asian socio-cultural context are not fully represented in the most commonly used instruments. Further studies on the selection of main domains relevant to HOA patients are necessary. © 2016 The Authors. International Journal of Rheumatic Diseases published by Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.

The ineffectiveness and unintended consequences of the public health war on obesity.

PubMed

Ramos Salas, Ximena

2015-02-03

The public health war on obesity has had little impact on obesity prevalence and has resulted in unintended consequences. Its ineffectiveness has been attributed to: 1) heavy focus on individual-based approaches and lack of scaled-up socio-environmental policies and programs, 2) modest effects of interventions in reducing and preventing obesity at the population level, and 3) inappropriate focus on weight rather than health. An unintended consequence of these policies and programs is excessive weight preoccupation among the population, which can lead to stigma, body dissatisfaction, dieting, disordered eating, and even death from effects of extreme dieting, anorexia, and obesity surgery complications, or from suicide that results from weight-based bullying. Future public health approaches should: a) avoid simplistic obesity messages that focus solely on individuals' responsibility for weight and health, b) focus on health outcomes rather than weight control, and c) address the complexity of obesity and target both individual-level and system-level determinants of health.

Internalised HIV-stigma, loneliness, depressive symptoms and sleep quality in people living with HIV.

PubMed

Fekete, Erin M; Williams, Stacey L; Skinta, Matthew D

2018-03-01

People living with HIV (PLWH) commonly report sleep disturbances which are associated with long-term health consequences, including disease progression. PLWH also experience internalised stigma as a result of their HIV status, which can be associated with increased loneliness and depression. Little attention focuses on the impact of these factors on sleep. Therefore, we examined whether internalised HIV-stigma was indirectly related to poorer sleep quality through higher levels of loneliness and depressive symptoms. 181 PLWH from across the United States completed an online survey. Main Study Measures: Internalised HIV-stigma was assessed using the HIV-Stigma Scale, loneliness was assessed using the UCLA-Loneliness Scale-Short Form, depressive symptoms were assessed with the Center for Epidemiologic Studies-Depression Index, and Sleep Quality was assessed using the Pittsburgh Sleep Quality Index. Internalised HIV-stigma was indirectly associated with poorer global sleep quality and daytime sleep dysfunction through both loneliness and depressive symptoms. PLWH who experience HIV-related stigma may experience greater feelings of loneliness, which are related to increased depressive symptoms and poorer sleep quality. Interventions focused on improving sleep in PLWH should focus on multiple factors that influence sleep, including psychosocial factors such as stigma, social isolation and depressive symptoms.

Does the risk of reprisal prevent nurses blowing the whistle on bad practice?

PubMed

Whitehead, Bill; Barker, Denise

Despite the introduction of legislation to protect people who report poor or unsafe practice, whistleblowing can still have serious consequences for nurses. To review the literature on whistleblowing in healthcare, and explore the barriers to reporting poor practice. Studies focusing on whistleblowing in healthcare were used to assess the safety of incident reporting, and to determine what prevented nurses from reporting poor practice. Four major themes were identified as the main barriers to whistleblowing in healthcare: experience of the nurse; confidentiality and reporting processes; incident severity; and personal beliefs. Reprisal for whistleblowing remains a major concern for nurses. Patient safety could be improved by prioritising confidentiality and creating an environment where nurses feel safe to report poor practice.

Lessons Learned in Protection of the Public for the Accident at the Fukushima Daiichi Nuclear Power Plant.

PubMed

Callen, Jessica; Homma, Toshimitsu

2017-06-01

What insights can the accident at the Fukushima Daiichi nuclear power plant provide in the reality of decision making on actions to protect the public during a severe reactor and spent fuel pool emergency? In order to answer this question, and with the goal of limiting the consequences of any future emergencies at a nuclear power plant due to severe conditions, this paper presents the main actions taken in response to the emergency in the form of a timeline. The focus of this paper is those insights concerning the progression of an accident due to severe conditions at a light water reactor nuclear power plant that must be understood in order to protect the public.

Indexed triangle strips optimization for real-time visualization using genetic algorithm: preliminary study

NASA Astrophysics Data System (ADS)

Tanaka, Kiyoshi; Takano, Shuichi; Sugimura, Tatsuo

2000-10-01

In this work we focus on the indexed triangle strips that is an extended representation of triangle strips to improve the efficiency for geometrical transformation of vertices, and present a method to construct optimum indexed triangle strips using Genetic Algorithm (GA) for real-time visualization. The main objective of this work is how to optimally construct indexed triangle strips by improving the ratio that reuses the data stored in the cash memory and simultaneously reducing the total index numbers with GA. Simulation results verify that the average index numbers and cache miss ratio per polygon cold be small, and consequently the total visualization time required for the optimum solution obtained by this scheme could be remarkably reduced.

Palliative care and the intensive care nurses: feelings that endure.

PubMed

Silveira, Natyele Rippel; Nascimento, Eliane Regina Pereira do; Rosa, Luciana Martins da; Jung, Walnice; Martins, Sabrina Regina; Fontes, Moisés Dos Santos

2016-01-01

to know the feelings of nurses regarding palliative care in adult intensive care units. qualitative study, which adopted the theoretical framework of Social Representations, carried out with 30 nurses of the state of Santa Catarina included by Snowball sampling. Data were collected through semi-structured interviews conducted from April to August 2015, organized and analyzed through the Collective Subject Discourse. the results showed how central ideas are related to feelings of comfort, frustration, insecurity and anguish, in addition to the feeling that the professional training and performance are focused on the cure. the social representations of nurses regarding the feelings related to palliative care are represented mainly by negative feelings, probably as consequence of the context in which care is provided.

Research in Mental Health: Social Etiology versus Social Consequences

ERIC Educational Resources Information Center

Aneshensel, Carol S.

2005-01-01

This article differentiates a social etiology model focused on identifying the social antecedents of one particular mental disorder from a social consequences model concerned with the overall mental health consequences of various social arrangements. In the social etiology model, people with disorders other than the one particular disorder singled…

Aging of cell membranes: facts and theories.

PubMed

Zs-Nagy, Imre

2014-01-01

This chapter is intended to outline the main results of a research trend realized by the author during the last 45 years, focused on the main role played by the cell membrane in the aging process. It is a very wide field; therefore, the reader cannot expect in this limited space a detailed description, but will be given a wide, interdisciplinary insight into the main facts and theories regarding cellular aging. The central idea described here is the concept called the membrane hypothesis of aging (MHA). The history, the chemical roots, physicochemical facts, biophysical processes, as well as the obligatory biochemical consequences are all touched in by indicating the most important sources of detailed knowledge for those who are more interested in the basic biology of the aging process. This chapter covers also the available anti-aging interventions on the cell membrane by means of the centrophenoxine treatment based on the MHA. It also briefly interprets the possibilities of a just developing anti-aging method by using the recombinant human growth hormone, essential basis of which is the species specificity, and the general presence of receptors of this hormone in the plasma membrane of all types of cells.

Obesity determinants in Mexican preschool children: parental perceptions and practices related to feeding and physical activity.

PubMed

Rodríguez-Oliveros, Guadalupe; Haines, Jess; Ortega-Altamirano, Doris; Power, Elaine; Taveras, Elsie M; González-Unzaga, Marco A; Reyes-Morales, Hortensia

2011-08-01

Obesity represents a major public health problem worldwide. In Mexico, overweight and obesity have increased dramatically, affecting 26% of school-aged children. The aim of this study was to explore perceptions and practices of key obesity determinants among parents of preschool children attending child care centers. We conducted five focus groups with 38 parents from six Mexico City child care centers. Inquiry topics were 1) childhood obesity causes and consequences; 2) child feeding practices at the child care center and home; 3) healthful and unhealthful foods for young children; 4) significance of physical activity in childhood; and 5) physical activity-promoting factors and barriers. We analyzed these data using content analysis. We identified a number of barriers to healthful eating, including parental time constraints, permissive feeding styles, unhealthful food preparation practices, lack of knowledge about nutrition, food advertisement, and high availability of unhealthful foods in public places. Facilitators to healthful eating included recognition of childhood overweight prevention and consequences, and healthy food choices. Main barriers to childhood physical activity included influence of young family members to play video games, parental time constraints, street safety, low access to sports facilities, and insufficient communication with child care centers. Understanding parental views and perceptions of the main factors influencing preschoolers' weight-related behavior can inform home-based or environmental interventions that support healthful eating and regular physical activity. Copyright © 2011 IMSS. Published by Elsevier Inc. All rights reserved.

Fear, an unpleasant experience among undergraduate midwifery students: A qualitative study.

PubMed

Ahmadi, Golnoosh; Shahriari, Mohsen; Kohan, Shahnaz; Keyvanara, Mahmood

2018-03-01

Fear is a normal emotion that can evoke an appropriate response when facing threat. However, sometimes the consequences of fear can lead to responses that are maladaptive. Fear can have negative effects on learning. Research has focused on the experience of fear and its consequences among midwifery students during their undergraduate program. A qualitative analysis was conducted of interviews with ten midwifery students in different years of an undergraduate program. The data was analyzed through a content analysis approach. Two main categories and five subcategories emerged. The first category, areas of fear in midwifery students, consisted of the following subcategories: fear of doing harm, fear of encountering their first childbirth, and fear of penalties. The second category, consequences of fear, consisted of the following subcategories: general physical and psychological consequences and interference in adopting the professional role. In this study, fear not only raised the students' stress levels thereby, leading to physical and psychological issues but also hindered their adoption of their professional role. These findings will potentially inform support and retention strategies within midwifery undergraduate programs in the future. Maternity care in Iran is provided mainly within a medical model of care. The majority of women give birth in hospital, where care is provided by midwives who work under the direction and supervision of an obstetrician. Midwives within the medically dominated system lack autonomy and have very little opportunity to gain experience in providing continuity of care for women as midwife-led models of care are rare. This practice context means that midwifery students have very little opportunity to gain experience in autonomous midwifery practice. Midwifery undergraduate program in Iran is for four years. Admission to the undergraduate program is implemented via a direct entry route. Nearly all of the midwifery students are school leavers with their first exposure to university and hospital systems. Most of the midwifery students have chosen this career without sufficient understanding about midwifery and the work that it involves (Arfaee et al., 2008). The midwifery undergraduate program comprises theoretical and clinical elements. After the first semester, students enter clinical settings under the supervision of their clinical instructors. Copyright © 2017 Elsevier Ltd. All rights reserved.

The costs and consequences of obesity in Germany: a new approach from a prevalence and life-cycle perspective.

PubMed

Effertz, Tobias; Engel, Susanne; Verheyen, Frank; Linder, Roland

2016-12-01

With the steadily growing health burden of obesity in Germany, the measuring and quantification of its costs and relevant economic consequences have become increasingly important. The usual quantifications via previous cost-of-illness approaches mostly have several weaknesses, e.g., applying "indirect methods" by using "population-attributable fractions" to identify parts of costs that can be accrued to obesity, second using highly aggregated data and third often only displaying part of the costs. This article presents a new approach and a new estimation of the cost and consequences of obesity in Germany using claims data from a German health insurance company. A sample of 146,000 individuals was analyzed with both a prevalence and a life-cycle focus on the cost and consequences of obesity. With additional data sets, we calculate the deaths per year due to obesity, the excess costs per year and several intangible consequences usually referred to as "pain and suffering". Our results show that the cost estimations of obesity in Germany so far have been largely underestimated. The annual direct costs of obesity in Germany amount to approximately €29.39 billion and the indirect costs to an additional €33.65 billion. A total of 102,000 subjects die prematurely each year because of obesity, and there is a significant excess of unemployment, long-term nursing care, and pain and suffering due to obesity. From a lifetime perspective, every obese man is equal to an additional burden of €166,911 and each woman of €206,526 for the social security system in Germany. Obesity due to unhealthy eating is thus about to replace tobacco consumption in terms of costs and consequences as the main hazardous lifestyle factor and thus should be more intensively focussed by public health policy.

Flood risk change in some European, African and Asian catchments

NASA Astrophysics Data System (ADS)

Kreibich, Heidi

2017-04-01

In light of the expected increase of flood risk in large parts of the world due to climate change and globally increasing exposure, efficient integrated flood risk management needs to be implemented. Societies learn from floods, and consequently improve their risk management. Such learning can occur through 'focusing events', i.e. events that provide a sudden, strong push for action. For example, the 1953 North Sea flood triggered the Delta Works in The Netherlands and the construction of the Thames Barrier. We show how societies have learnt from focusing events in river systems, by a semi-quantitative assessment of eight paired flood events around the world, i.e. consecutive floods that occurred in the same catchments, with the second flood causing significantly lower damage. We unravel the main mechanisms underlying these eight success stories of risk reduction. Across all case studies, we find that lower damage caused by the second event was mainly due to significant reductions in vulnerability. The role of changes in exposure is less apparent; positive and negative changes are reported. In some cases, significant investments in flood protection between the floods have played a large role in exposure and damage reduction. Reduction of vulnerability seems to be a key for better risk reduction via integrated flood risk management. Thus, we need to redouble efforts to improve our understanding of vulnerability.

Agrochemical-induced stress in stingless bees: peculiarities, underlying basis, and challenges.

PubMed

Lima, M A P; Martins, G F; Oliveira, E E; Guedes, R N C

2016-10-01

The toxicological stress induced by pesticides, particularly neonicotinoid insecticides, and its consequences in bees has been the focus of much recent attention, particularly for honey bees. However, the emphasis on honey bees and neonicotinoids has led to neglect of the relevance of stingless bees, the prevailing pollinators of natural and agricultural tropical ecosystems, and of other agrochemicals, including other pesticides and even leaf fertilizers. Consequently, studies focusing on agrochemical effects on stingless bees are sparse, usually limited to histopathological studies, and lack a holistic assessment of the effects of these compounds on physiology and behavior. Such effects have consequences for individual and colony fitness and are likely to affect both the stingless bee populations and the associated community, thereby producing a hierarchy of consequences thus far overlooked. Herein, we review the current literature on stingless bee-agrochemical interactions and discuss the underlying mechanisms involved in reported stress symptoms, as well as the potential consequences based on the peculiarities of these pollinators.

Determination of rate of customer focus in educational programs at Isfahan University of Medical Sciences(1) based on students' viewpoints.

PubMed

Shams, Assadollah; Yarmohammadian, Mohammad Hosein; Abbarik, Hadi Hayati

2012-01-01

Today, the challenges of quality improvement and customer focus as well as systems development are important and inevitable matters in higher education institutes. There are some highly competitive challenges among educational institutes, including accountability to social needs, increasing costs of education, diversity in educational methods and centers and their consequent increasing competition, and the need for adaptation of new information and knowledge to focus on students as the main customers. Hence, the purpose of this study was to determine the rate of costumer focus based on Isfahan University of Medical Sciences students' viewpoints and to suggest solutions to improve this rate. This was a cross-sectional study carried out in 2011. The statistical population included all the students of seven faculties of Isfahan University of Medical Sciences. According to statistical formulae, the sample size consisted of 384 subjects. Data collection tools included researcher-made questionnaire whose reliability was found to be 87% by Cronbach's alpha coefficient. Finally, using the SPSS statistical software and statistical methods of independent t-test and one-way analysis of variance (ANOVA), Likert scale based data were analyzed. The mean of overall score for customer focus (student-centered) of Isfahan University of Medical Sciences was 46.54. Finally, there was a relation between the mean of overall score for customer focus and gender, educational levels, and students' faculties. Researcher suggest more investigation between Medical University and others. It is a difference between medical sciences universities and others regarding the customer focus area, since students' gender must be considered as an effective factor in giving healthcare services quality. In order to improve the customer focus, it is essential to take facilities, field of study, faculties, and syllabus into consideration.

Determination of rate of customer focus in educational programs at Isfahan University of Medical Sciences1 based on students’ viewpoints

PubMed Central

Shams, Assadollah; Yarmohammadian, Mohammad Hosein; Abbarik, Hadi Hayati

2012-01-01

Background: Today, the challenges of quality improvement and customer focus as well as systems development are important and inevitable matters in higher education institutes. There are some highly competitive challenges among educational institutes, including accountability to social needs, increasing costs of education, diversity in educational methods and centers and their consequent increasing competition, and the need for adaptation of new information and knowledge to focus on students as the main customers. Hence, the purpose of this study was to determine the rate of costumer focus based on Isfahan University of Medical Sciences students’ viewpoints and to suggest solutions to improve this rate. Materials and Methods: This was a cross-sectional study carried out in 2011. The statistical population included all the students of seven faculties of Isfahan University of Medical Sciences. According to statistical formulae, the sample size consisted of 384 subjects. Data collection tools included researcher-made questionnaire whose reliability was found to be 87% by Cronbach's alpha coefficient. Finally, using the SPSS statistical software and statistical methods of independent t-test and one-way analysis of variance (ANOVA), Likert scale based data were analyzed. Results: The mean of overall score for customer focus (student-centered) of Isfahan University of Medical Sciences was 46.54. Finally, there was a relation between the mean of overall score for customer focus and gender, educational levels, and students’ faculties. Researcher suggest more investigation between Medical University and others. Conclusion: It is a difference between medical sciences universities and others regarding the customer focus area, since students’ gender must be considered as an effective factor in giving healthcare services quality. In order to improve the customer focus, it is essential to take facilities, field of study, faculties, and syllabus into consideration. PMID:23555127

Addressing the Needs of Preschool Children in the Context of Disasters and Terrorism: Clinical Pictures and Moderating Factors.

PubMed

Hamiel, Daniel; Wolmer, Leo; Pardo-Aviv, Lee; Laor, Nathaniel

2017-07-01

This paper surveys the existent theoretical and research literature regarding the needs of preschool children in the context of disasters and terrorism with the aim of understanding (a) the consequences of such events for young children and (b) the main moderating variables influencing the event-consequence association to learn how to enhance their resilience. Consequences include a variety of emotional, behavioral, and biological outcomes. Implications for refugee children are discussed. Main moderating variables were mother's sensitivity and mother's PTSD symptoms. Exposure to disasters and terrorism may have severe effects on the mental health and development among preschool children. Future research should explore the implications of different levels of exposure and the effects of moderating psychosocial and biological variables, including the parent-child triad, on the event-consequence relationship.

2009 AERA Distinguished Lecture: Causes and Consequences of Cognitive Functioning across the Life Course

ERIC Educational Resources Information Center

Hauser, Robert M.

2010-01-01

Research on variation in cognitive abilities has focused largely on their genetic or experiential sources and on their economic consequences. This article takes a broader look at the consequences of cognitive ability--IQ--across the life course. Contrary to received wisdom, the effects of IQ on economic success are almost entirely mediated by…

Focus Groups of Parents and Teens Help Develop Messages to Prevent Early Marijuana Use in the Context of Legal Retail Sales.

PubMed

Skinner, Martie L; Haggerty, Kevin P; Casey-Goldstein, Mary; Thompson, Ronald W; Buddenberg, Laura; Mason, W Alex

2017-02-23

The changes in Washington State and Colorado marijuana laws call for the development of new brief family-focused adolescent marijuana use preventive interventions that are relevant for and tailored to the context of legalization for retail sale. To that end, focus groups with parents and teens were conducted to find out about their concerns and needs in the context of legalization. Six semi-structured focus groups (3 with parents, 3 with teens) were conducted in Washington State in 2013 related to consequences of teen marijuana use and messages that would be effective in helping to prevent teens from using marijuana in the context of legal adult use. A total of 33 teens and 35 parents participated. Three primary themes were common to these parents and teens: the negative consequences of marijuana use during adolescence on mental, physical, and social health; the need for more or better information; and the need for information/messages to come from trusted sources. The themes related to potential prevention messages include the use of fear; stories about real people; focusing on short-term consequences; and teens needing alternative activities (something better to do). The results suggest that parents and teens need information about the new retail marijuana legalization law. Teens are open to both information and guidance from parents as long as it is calm and respectful. Firsthand accounts of consequences of marijuana use from peers and adults, rather than threats from authority figures, could hold some promise for persuading teens to avoid marijuana use.

Focus Groups of Parents and Teens Help Develop Messages to Prevent Early Marijuana Use in the Context of Legal Retail Sales

PubMed Central

Skinner, Martie L.; Haggerty, Kevin P.; Casey-Goldstein, Mary; Thompson, Ronald W.; Buddenberg, Laura; Mason, W. Alex

2016-01-01

Purpose The changes in Washington State and Colorado marijuana laws call for the development of new brief family-focused adolescent marijuana use preventive interventions that are relevant for and tailored to the context of legalization for retail sale. To that end, focus groups with parents and teens were conducted to find out about their concerns and needs in the context of legalization. Methods Six semi-structured focus groups (3 with parents, 3 with teens) were conducted in Washington State in 2013 related to consequences of teen marijuana use and messages that would be effective in helping to prevent teens from using marijuana in the context of legal adult use. A total of 33 teens and 35 parents participated. Results Three primary themes were common to these parents and teens: the negative consequences of marijuana use during adolescence on mental, physical, and social health; the need for more or better information; and the need for information/messages to come from trusted sources. The themes related to potential prevention messages include the use of fear; stories about real people; focusing on short-term consequences; and teens needing alternative activities (something better to do). Conclusions The results suggest that parents and teens need information about the new retail marijuana legalization law. Teens are open to both information and guidance from parents as long as it is calm and respectful. Firsthand accounts of consequences of marijuana use from peers and adults, rather than threats from authority figures, could hold some promise for persuading teens to avoid marijuana use. PMID:27768528

An Alternative Perspective on von Winterfeldt et al.'s (1997) Test of Consequence Monotonicity

ERIC Educational Resources Information Center

Ho, Moon-Ho R.; Regenwetter, Michel; Niederee, Reinhard; Heyer, Dieter

2005-01-01

D. von Winterfeldt, N.-K. Chung, R. D. Luce, and Y. Cho (see record 1997-03378-008) provided several tests for consequence monotonicity of choice or judgment, using certainty equivalents of gambles. The authors reaxiomatized consequence monotonicity in a probabilistic framework and reanalyzed von Winterfeldt et al.'s main experiment via a…

Recent advances in the design of tailored nanomaterials for efficient oxygen reduction reaction

DOE PAGES

Lv, Haifeng; Li, Dongguo; Strmcnik, Dusan; ...

2016-04-11

In the past decade, polymer electrolyte membrane fuels (PEMFCs) have been evaluated for both automotive and stationary applications. One of the main obstacles for large scale commercialization of this technology is related to the sluggish oxygen reduction reaction that takes place on the cathode side of fuel cell. Consequently, ongoing research efforts are focused on the design of cathode materials that could improve the kinetics and durability. Majority of these efforts rely on novel synthetic approaches that provide control over the structure, size, shape and composition of catalytically active materials. This article highlights the most recent advances that have beenmore » made to tailor critical parameters of the nanoscale materials in order to achieve more efficient performance of the oxygen reduction reaction (ORR).« less

Bruxism: Is There an Indication for Muscle-Stretching Exercises?

PubMed

Gouw, Simone; de Wijer, Anton; Creugers, Nico Hj; Kalaykova, Stanimira I

Bruxism is a common phenomenon involving repetitive activation of the masticatory muscles. Muscle-stretching exercises are a recommended part of several international guidelines for musculoskeletal disorders and may be effective in management of the jaw muscle activity that gives rise to bruxism. However, most studies of muscle-stretching exercises have mainly focused on their influence on performance (eg, range of motion, coordination, and muscle strength) of the limb or trunk muscles of healthy individuals or individuals with sports-related injuries. Very few have investigated stretching of the human masticatory muscles and none muscle-stretching exercises in the management of (sleep) bruxism. This article reviews the literature on muscle-stretching exercises and their potential role in the management of sleep bruxism or its consequences in the musculoskeletal system.

Current Insights into the Modulation of Oral Bacterial Degradation of Dental Polymeric Restorative Materials

PubMed Central

Zhang, Ning; Ma, Yansong; Weir, Michael D.; Xu, Hockin H. K.; Bai, Yuxing; Melo, Mary Anne S.

2017-01-01

Dental polymeric composites have become the first choice for cavity restorations due to their esthetics and capacity to be bonded to the tooth. However, the oral cavity is considered to be harsh environment for a polymeric material. Oral biofilms can degrade the polymeric components, thus compromising the marginal integrity and leading to the recurrence of caries. Recurrent caries around restorations has been reported as the main reason for restoration failure. The degradation of materials greatly compromises the clinical longevity. This review focuses on the degradation process of resin composites by oral biofilms, the mechanisms of degradation and its consequences. In addition, potential future developments in the area of resin-based dental biomaterials with an emphasis on anti-biofilm strategies are also reviewed. PMID:28772863

Scaling Up Decision Theoretic Planning to Planetary Rover Problems

NASA Technical Reports Server (NTRS)

Meuleau, Nicolas; Dearden, Richard; Washington, Rich

2004-01-01

Because of communication limits, planetary rovers must operate autonomously during consequent durations. The ability to plan under uncertainty is one of the main components of autonomy. Previous approaches to planning under uncertainty in NASA applications are not able to address the challenges of future missions, because of several apparent limits. On another side, decision theory provides a solid principle framework for reasoning about uncertainty and rewards. Unfortunately, there are several obstacles to a direct application of decision-theoretic techniques to the rover domain. This paper focuses on the issues of structure and concurrency, and continuous state variables. We describes two techniques currently under development that address specifically these issues and allow scaling-up decision theoretic solution techniques to planetary rover planning problems involving a small number of goals.

iPSCs-based anti-aging therapies: Recent discoveries and future challenges.

PubMed

Pareja-Galeano, Helios; Sanchis-Gomar, Fabián; Pérez, Laura M; Emanuele, Enzo; Lucia, Alejandro; Gálvez, Beatriz G; Gallardo, María Esther

2016-05-01

The main biological hallmarks of the aging process include stem cell exhaustion and cellular senescence. Consequently, research efforts to treat age-related diseases as well as anti-aging therapies in general have recently focused on potential 'reprogramming' regenerative therapies. These new approaches are based on induced pluripotent stem cells (iPSCs), including potential in vivo reprogramming for tissue repair. Another possibility is targeting pathways of cellular senescence, e.g., through modulation of p16INK4a signaling and especially inhibition of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Here, we reviewed and discussed these recent developments together with their possible usefulness for future treatments against sarcopenia, a major age-related condition. Copyright © 2016 Elsevier B.V. All rights reserved.

[The celestial phenomena in A. Dürer's engraving Melancholia I].

PubMed

Weitzel, Hans

2009-01-01

The celestial body of Dürer's engraving Melencolia I is connected with his painting of a meteor, the Raveningham-painting; it is shown that the origin of this painting owns to the impact of the meteor of Ensisheim in 1492. Until now the celestial body, the balance, and the magic square are nearly consistently interpreted as the planet Saturn, the zodiac sign Libra, and the planet Jupiter, and the melancholy woman is subject to these heavenly bodies. Consequently, neoplatonic astrology has been the main focus of the engraving; including the rainbow, the engraving has also been interpreted biblically. The present paper, however, places emphasis on problems of the geometry as the reason of melancholy. Any astronomical meaning of the configuration of the numbers of the magic square is discarded.

Cyberbullying Awareness for Mitigating Consequences in Higher Education.

PubMed

Elçi, Alev; Seçkin, Zeliha

2016-04-28

Technology has many positive effects on education, but negative effects also exist. One of the negative effects is cyberbullying spreading out of school boundaries to the social networks. The increasing popularity of social media among youngsters engenders cyberbullies who exploit the virtual environment besides the usual emails. This distresses the students and adversely affects their families, teachers, and others around them. Although research studies mainly concentrate on prior education, there seems to be a need to investigate the situation in higher education. This study focuses on students studying technology and related disciplines, who are hence likely to be well connected with cyberspace, and explores their awareness about cyberbullying. The findings reveal that female students have significantly less awareness than males. This study will help address some gender issues in cyberbullying. © The Author(s) 2016.

Daily chicken: the cultural transmission of bourgeois family values in adaptations of literary classics for children, 1850-1950.

PubMed

Parlevliet, Sanne

2011-01-01

Literature is a significant agent in the transmission of culture. Through literature expected behavior and patterns of life are passed on from generation to generation. The anticipated power of children's literature is even stronger. Socializing the target audience has always been one of its main aims. Consequently, books for children are governed by dominant social, cultural, and educational norms. This article explores the reciprocity between cultural transmission and the transmission of literature. It examines adaptations of international literary classics in their capacity of cultural intermediaries between old masterpieces and young audiences. Focusing on ways of transmitting family ideologies to children, the repository of Dutch adaptations of "Reynard the Fox," "Till Eulenspiegel," "Robinson Crusoe," and "Gulliver's Travels" serves as a case study.

A hydrogeologic model of stratiform copper mineralization in the Midcontinent Rift System, Northern Michigan, USA

USGS Publications Warehouse

Swenson, J.B.; Person, M.; Raffensperger, Jeff P.; Cannon, W.F.; Woodruff, L.G.; Berndt, M.E.

2004-01-01

This paper presents a suite of two-dimensional mathematical models of basin-scale groundwater flow and heat transfer for the middle Proterozoic Midcontinent Rift System. The models were used to assess the hydrodynamic driving mechanisms responsible for main-stage stratiform copper mineralization of the basal Nonesuch Formation during the post-volcanic/pre-compressional phase of basin evolution. Results suggest that compaction of the basal aquifer (Copper Harbor Formation), in response to mechanical loading during deposition of the overlying Freda Sandstone, generated a pulse of marginward-directed, compaction-driven discharge of cupriferous brines from within the basal aquifer. The timing of this pulse is consistent with the radiometric dates for the timing of mineralization. Thinning of the basal aquifer near White Pine, Michigan, enhanced stratiform copper mineralization. Focused upward leakage of copper-laden brines into the lowermost facies of the pyrite-rich Nonesuch Formation resulted in copper sulfide mineralization in response to a change in oxidation state. Economic-grade mineralization within the White Pine ore district is a consequence of intense focusing of compaction-driven discharge, and corresponding amplification of leakage into the basal Nonesuch Formation, where the basal aquifer thins dramatically atop the Porcupine Mountains volcanic structure. Equilibrium geochemical modeling and mass-balance calculations support this conclusion. We also assessed whether topography and density-driven flow systems could have caused ore genesis at White Pine. Topography-driven flow associated with the Ottawan orogeny was discounted because it post-dates main-stage ore genesis and because recent seismic interpretations of basin inversion indicates that basin geometry would not be conductive to ore genesis. Density-driven flow systems did not produce focused discharge in the vicinity of the White Pine ore district.

Can classic moral stories promote honesty in children?

PubMed

Lee, Kang; Talwar, Victoria; McCarthy, Anjanie; Ross, Ilana; Evans, Angela; Arruda, Cindy

2014-08-01

The classic moral stories have been used extensively to teach children about the consequences of lying and the virtue of honesty. Despite their widespread use, there is no evidence whether these stories actually promote honesty in children. This study compared the effectiveness of four classic moral stories in promoting honesty in 3- to 7-year-olds. Surprisingly, the stories of "Pinocchio" and "The Boy Who Cried Wolf" failed to reduce lying in children. In contrast, the apocryphal story of "George Washington and the Cherry Tree" significantly increased truth telling. Further results suggest that the reason for the difference in honesty-promoting effectiveness between the "George Washington" story and the other stories was that the former emphasizes the positive consequences of honesty, whereas the latter focus on the negative consequences of dishonesty. When the "George Washington" story was altered to focus on the negative consequences of dishonesty, it too failed to promote honesty in children. © The Author(s) 2014.

Fish and aquatic habitat conservation in South America: a continental overview with emphasis on neotropical systems.

PubMed

Barletta, M; Jaureguizar, A J; Baigun, C; Fontoura, N F; Agostinho, A A; Almeida-Val, V M F; Val, A L; Torres, R A; Jimenes-Segura, L F; Giarrizzo, T; Fabré, N N; Batista, V S; Lasso, C; Taphorn, D C; Costa, M F; Chaves, P T; Vieira, J P; Corrêa, M F M

2010-06-01

Fish conservation in South America is a pressing issue. The biodiversity of fishes, just as with all other groups of plants and animals, is far from fully known. Continuing habitat loss may result in biodiversity losses before full species diversity is known. In this review, the main river basins of South America (Magdalena, Orinoco, Amazon and Paraná-La Plata system), together with key aquatic habitats (mangrove-fringed estuaries of the tropical humid, tropical semi-arid and subtropical regions) are analysed in terms of their characteristics and main concerns. Habitat loss was the main concern identified for all South American ecosystems. It may be caused by damming of rivers, deforestation, water pollution, mining, poor agricultural practice or inadequate management practice. Habitat loss has a direct consequence, which is a decrease in the availability of living resources, a serious social and economic issue, especially for South American nations which are all developing countries. The introduction of exotic species and overfishing were also identified as widespread across the continent and its main freshwater, coastal and marine ecosystems. Finally, suggestions are made to find ways to overcome these problems. The main suggestion is a change of paradigm and a new design for conservation actions, starting with integrated research and aiming at the co-ordinated and harmonized management of the main transboundary waters of the continent. The actions would be focused on habitat conservation and social rescue of the less well-off populations of indigenous and non-indigenous peoples. Energy and freshwater demands will also have to be rescaled in order to control habitat loss.

[Neuropsychological sequelae of deportation to the Nazi concentration camps during the Second World War].

PubMed

Abalan, F; Martínez-Gallardo, R; Bourgeois, M

1989-01-01

The essential neuropsychic consequences of the deportation to the nazi concentration camps of adults during the second world war are the "KZ syndrome", the survival syndrome (or persecution syndrome) and reactive schizophrenias. The "KZ syndrome" puts together a psychic asthenia, a progressive intellectual deterioration, anxiety, depressive mood and vegetative disturbances. It is brought about as a consequence of malnutrition and the psychic traumas suffered by those deported. It shows up mainly in the non-jewish deported. The survival syndrome is chronic, puts together anxiety, insomnia and nightmares, repetitive memories relative to the period of persecution, depressive symptoms, somatic complaints, neurovegetative disturbances and hypervigilance. It is observed mainly in those deported that are jewish. It is produced as a consequence of very severe psychic traumas suffered by the jewish deportees. Some reactive schizophrenias described in deported jews seem to be the direct consequence of psychic traumas of an extreme intensity.

Strategies to reduce plate waste in primary schools - experimental evaluation.

PubMed

Liz Martins, Margarida; Rodrigues, Sara Sp; Cunha, Luís M; Rocha, Ada

2016-06-01

To determine and compare the effect of two interventions in reducing the plate waste of school lunches. A between-group analysis was conducted among children from three primary schools: (i) a group receiving intervention A, designed for children and focusing on nutrition education and food waste; (ii) a group receiving intervention B, intended for teachers and focusing on the causes and consequences of food waste; and (iii) a control group with no intervention. For each child, physical weighing of individual meals and leftovers was performed on three non-consecutive weeks at baseline (T0), 1 week (T1, short term) and 3 months (T2, medium term) following the intervention. Plate waste was recorded for a total of 1742 lunches during 14 d over eight different menus. Portuguese public primary schools in the city of Porto. All fourth-grade children (n 212) attending the three preselected schools. After intervention A focusing on nutrition education designed for children, a decrease in soup waste was observed compared with the control group. The effect was greater at T1 (-11·9 (se 2·8) %; P<0·001) than at T2 (-5·8 (se 4·4) %; P=0·103). The plate waste of identical main dishes decreased strongly at T1 (-33·9 (se 4·8) %; P<0·001). However, this effect was not found at T2 (-13·7 (se 3·2) %; P<0·001). After intervention B involving teachers, plate waste decreased at T2 (-5·5 (se 1·9) % for soup; -5·4 (se 2·4) % for identical main dishes). Nutrition education designed for children was more effective in the short than the medium term. Thus, this kind of intervention was not effective in reducing food waste in the medium term. In contrast, an intervention focusing on teachers revealed better results in the medium term than in the short term.

International labor migration and the family: some observations from Indonesia.

PubMed

Hugo, G

1995-01-01

This article addresses two dimensions of the complex interrelationship between the family and international labor migration in Indonesia: the role of the family in influencing labor movements out of Indonesia; and the consequences of this movement on family well-being, structure, and functioning. Research on this topic in Indonesia is highly limited due mainly to the recency of large scale international labor migration, inadequate data collection systems, a high incidence of undocumented migration, and failure of available research to be sensitive to family related issues. Against a rapidly changing economic and social situation, two major overlapping systems of migration have developed. The official system is focused strongly on the Middle East (although other Asian destinations are increasing in significance) and is dominated by female migrants. The undocumented system is much larger in volume, is focused upon Malaysia, involves more males than females, and is becoming permanent in some cases. The role, status, and experiences of women migrants in relation to their families (decision making, networks, remittances) are discussed with recommendations for other areas needing further research attention.

A High-Efficiency Wind Energy Harvester for Autonomous Embedded Systems

PubMed Central

Brunelli, Davide

2016-01-01

Energy harvesting is currently a hot research topic, mainly as a consequence of the increasing attractiveness of computing and sensing solutions based on small, low-power distributed embedded systems. Harvesting may enable systems to operate in a deploy-and-forget mode, particularly when power grid is absent and the use of rechargeable batteries is unattractive due to their limited lifetime and maintenance requirements. This paper focuses on wind flow as an energy source feasible to meet the energy needs of a small autonomous embedded system. In particular the contribution is on the electrical converter and system integration. We characterize the micro-wind turbine, we define a detailed model of its behaviour, and then we focused on a highly efficient circuit to convert wind energy into electrical energy. The optimized design features an overall volume smaller than 64 cm3. The core of the harvester is a high efficiency buck-boost converter which performs an optimal power point tracking. Experimental results show that the wind generator boosts efficiency over a wide range of operating conditions. PMID:26959018

A High-Efficiency Wind Energy Harvester for Autonomous Embedded Systems.

PubMed

Brunelli, Davide

2016-03-04

Energy harvesting is currently a hot research topic, mainly as a consequence of the increasing attractiveness of computing and sensing solutions based on small, low-power distributed embedded systems. Harvesting may enable systems to operate in a deploy-and-forget mode, particularly when power grid is absent and the use of rechargeable batteries is unattractive due to their limited lifetime and maintenance requirements. This paper focuses on wind flow as an energy source feasible to meet the energy needs of a small autonomous embedded system. In particular the contribution is on the electrical converter and system integration. We characterize the micro-wind turbine, we define a detailed model of its behaviour, and then we focused on a highly efficient circuit to convert wind energy into electrical energy. The optimized design features an overall volume smaller than 64 cm³. The core of the harvester is a high efficiency buck-boost converter which performs an optimal power point tracking. Experimental results show that the wind generator boosts efficiency over a wide range of operating conditions.

The scientist-practitioner model: how do advances in clinical and cognitive neuroscience affect neuropsychology in the courtroom?

PubMed

Wood, Rodger Ll

2009-01-01

One of the core tenets of the scientist-practitioner model, slightly modified to make it applicable to modern neuropsychology, is that assessment procedures should be developed, applied, and interpreted in a relevant scientific framework. However, over the last 30 years, the general structure of a neuropsychological assessment has changed little, if at all. It has continued to focus mainly on the assessment of cognitive constructs such as intelligence, memory, attention, and perception. During the same time period, cognitive neuroscience has focused on integrative systems, largely controlled by frontal mechanisms, that allow individuals to utilize cognitive functions in an adaptive way, especially in the context of novel situations or when social stimuli are ambiguous. Consequently, the gulf between cognitive neuroscience and the practice of clinical neuropsychology has grown uncomfortably large. This article attempts to review some of the developments in cognitive and affective neuroscience that are relevant to an evaluation of neuropsychological abilities, especially in a medicolegal context, to determine whether conventional neuropsychological methods can be considered fit for purpose.

Sexual identities and lifestyles among non-heterosexual urban Chiang Mai adolescents: implications for health

PubMed Central

Tangmunkongvorakul, Arunrat; Banwell, Cathy; Carmichael, Gordon; Utomo, Iwu Dwisetyani; Sleigh, Adrian

2011-01-01

Drawing upon quantitative and qualitative data we explore perspectives on and experiences of sexual lifestyles and relationships among more than 1,750 adolescents aged 17-20 years who reside in urban Chiang Mai, Thailand. We focus on respondents’ representations and understandings of their sexual/gender identities derived mainly from in-depth interviews and focus group discussions, supplemented with observations and field notes. Our results show that while many young Thais described themselves as heterosexual males or females others described themselves as gay, kathoey, tom, dii, bisexual or something else. Some were still questioning their own identities. The terms gay, kathoey, tom and dii are commonly used by these Thais to describe a range of sexual/gender identities relating to persons who are sexually or romantically attracted to the same biological sex. We use case studies to illustrate the distinctive characterizations, sexual lifestyles and relationships of each of these identities. We conclude that the sexual lifestyles encountered among Northern Thai non-heterosexual adolescents could lead to negative health consequences and indicated a need for improved relationship education, counselling and sensitive sexual health services. PMID:20665299

International pharmaceutical social risk regulation: An ethical perspective.

PubMed

Gordon, Cameron

2011-03-01

Pharmaceutical production and distribution constitute big business. For the companies the rewards can be substantial. Rates of return on drug company investments tend to be higher than many other manufacturing enterprises. But reward is only one side of the story. There is also the issue of social risk, the focus of this article. Social risk for pharmaceutical production is especially pronounced. An ineffective or, worse, dangerous drug, can have dire consequences for the population at large. For this reason, there is elaborate government regulation and oversight of drug safety and risk. These systems, especially in the US and Europe, will be the main focus of this paper. The two systems will be described, and then compared and contrasted in terms of their framing of social risk and actions governments take to limit it. Systems elsewhere, especially in the developing world, are increasing in relative importance and these will be briefly discussed as well. Ethical issues that have arisen in these various systems will be surfaced and analysed. The paper will close with some conclusions and suggestions for further research.

Focus on the success of others leads to selfish behavior

PubMed Central

van den Berg, Pieter; Molleman, Lucas; Weissing, Franz J.

2015-01-01

It has often been argued that the spectacular cognitive capacities of humans are the result of selection for the ability to gather, process, and use information about other people. Recent studies show that humans strongly and consistently differ in what type of social information they are interested in. Although some individuals mainly attend to what the majority is doing (frequency-based learning), others focus on the success that their peers achieve with their behavior (success-based learning). Here, we show that such differences in social learning have important consequences for the outcome of social interactions. We report on a decision-making experiment in which individuals were first classified as frequency- and success-based learners and subsequently grouped according to their learning strategy. When confronted with a social dilemma situation, groups of frequency-based learners cooperated considerably more than groups of success-based learners. A detailed analysis of the decision-making process reveals that these differences in cooperation are a direct result of the differences in information use. Our results show that individual differences in social learning strategies are crucial for understanding social behavior. PMID:25730855

Review article: Hydrological modeling in glacierized catchments of central Asia - status and challenges

NASA Astrophysics Data System (ADS)

Chen, Yaning; Li, Weihong; Fang, Gonghuan; Li, Zhi

2017-02-01

Meltwater from glacierized catchments is one of the most important water supplies in central Asia. Therefore, the effects of climate change on glaciers and snow cover will have increasingly significant consequences for runoff. Hydrological modeling has become an indispensable research approach to water resources management in large glacierized river basins, but there is a lack of focus in the modeling of glacial discharge. This paper reviews the status of hydrological modeling in glacierized catchments of central Asia, discussing the limitations of the available models and extrapolating these to future challenges and directions. After reviewing recent efforts, we conclude that the main sources of uncertainty in assessing the regional hydrological impacts of climate change are the unreliable and incomplete data sets and the lack of understanding of the hydrological regimes of glacierized catchments of central Asia. Runoff trends indicate a complex response to changes in climate. For future variation of water resources, it is essential to quantify the responses of hydrologic processes to both climate change and shrinking glaciers in glacierized catchments, and scientific focus should be on reducing uncertainties linked to these processes.

An Analysis of the Financial and Political Consequences Experienced by School Corporations when Closing a School or Consolidating Schools

ERIC Educational Resources Information Center

Morikis, Peter

2010-01-01

The purpose of this study was to identify the common consequences experienced by school corporations when closing or consolidating schools. The primary focus of the study was to identify the financial and political consequences experienced by school corporations when closing a school closing or consolidating schools. Specific questions regarding…

[The new organization of labor at public universities: collective consequences of job instability on the health of teachers].

PubMed

Souza, Katia Reis; Mendonça, André Luis Oliveira; Rodrigues, Andrea Maria Santos; Felix, Eliana Guimarães; Teixeira, Liliane Reis; Santos, Maria Blandina Marques; Moura, Marisa

2017-11-01

The main objective of this article is to analyze the new organization of labor of university teachers, seeking to investigate the potential relationship with the health status of these workers. It is based on the assumption that job instability in public universities has had repercussions on the health of higher education teachers. A qualitative exploratory study was conducted by means of bibliographic research in indexed databases. As a method of analysis, thematic analysis was used, focusing on four empirical categories, namely: job instability in the teaching profession; intensification of labor; aspects of the organization of teaching work in universities; and data on the health of university teachers. It was revealed in the literature that the use of strong organizational pressures prevails in the university scenario and consequently the intensification of labor is prevalent, with emphasis on the issue of increasing the demand for academic productivity. It was also observed that the topic of excess workload of teachers is recurrent and the concept of availability of less leisure time prevails. In addition, the need for organized collective resistance was confirmed in order to modify the job instability of teaching work.

Do immunotherapy and beta cell replacement play a synergistic role in the treatment of type 1 diabetes?

PubMed

Li, Dong-Sheng; Warnock, Garth L; Tu, Han-Jun; Ao, Ziliang; He, Zehua; Lu, Hong; Dai, Long-Jun

2009-10-07

Type 1 diabetes (T1D) is the result of the autoimmune response against pancreatic insulin-producing ss-cells. Its ultimate consequence is beta-cell insufficiency-mediated dysregulation of blood glucose control. In terms of T1D treatment, immunotherapy addresses the cause of T1D, mainly through re-setting the balance between autoimmunity and regulatory mechanisms. Regulatory T cells play an important role in this immune intervention. An alternative T1D treatment is beta-cell replacement, which can reverse the consequence of the disease by replacing destroyed beta-cells in the diabetic pancreas. The applicable insulin-producing cells can be directly obtained from islet transplantation or generated from other cell sources such as autologous adult stem cells, embryonic stem cells, and induced pluripotent stem cells. In this review, we summarize the recent research progress and analyze the possible advantages and disadvantages of these two therapeutic options especially focusing on the potential synergistic effect on T1D treatment. Exploring the optimal combination of immunotherapy and beta-cell replacement will pave the way to the most effective cure for this devastating disease.

Empowering the deaf. Let the deaf be deaf

PubMed Central

Munoz-Baell, I.; Ruiz, M

2000-01-01

Deafness is often regarded as just a one and only phenomenon. Accordingly, deaf people are pictured as a unified body of people who share a single problem. From a medical point of view, we find it usual to work with a classification of deafness in which pathologies attributable to an inner ear disorder are segregated from pathologies attributable to an outer/middle ear disorder. Medical intervention is thus concerned more with the origin, degree, type of loss, onset, and structural pathology of deafness than with communicative disability and the implications there may be for the patient (mainly dependency, denial of abnormal hearing behaviour, low self esteem, rejection of the prosthetic help, and the breakdown of social relationships). In this paper, we argue that hearing loss is a very complex phenomenon, which has many and serious consequences for people and involves many factors and issues that should be carefully examined. The immediate consequence of deafness is a breakdown in communication whereby the communicative function needs to be either initiated or restored. In that sense, empowering strategies—aimed at promoting not only a more traditional psychological empowerment but also a community one—should primarily focus on the removal of communication barriers.


Keywords: deafness PMID:10692961

Nail Biting; Etiology, Consequences and Management

PubMed Central

Ghanizadeh, Ahmad

2011-01-01

Nail biting (NB) is a common, but unresolved, problem in psychiatry, psychology, medicine and dentistry. While it seems that NB is a simple behavior that can be stopped easily, many of the children with NB have already tried to stop it, but they have not been successful. The frustrations due to failed attempt involve others such as parents and siblings. The present review aims at providing an overview of prevalence, co-morbidities, education and counseling, and management for NB. Overall, the reviewed literatures suggest that co-morbidities of psychiatric disorders and other stereotypic behaviors in clinical sample of children with NB is more than 80%, and more than half of the parents suffer from psychiatric disorders mainly depression. Treatment of NB, however, is not as easy as it seems. The management of NB is much more complicated than just focusing on stopping it. Nail biting cannot be managed without considering its co-morbidities, antecedents and consequences. It might be concluded form the reviewed literature that children with NB, parents, siblings, and teachers should be educated about what to do and what not to do about NB. Punishment is not effective. Moreover, clinical randomized controlled trials are required to make available evidence-based behavioral and pharmacologic treatment protocols. PMID:23358880

The Importance of Fostering Ownership during Medical Training

PubMed Central

Dubov, Oleksandr; Fraenkel, Liana; Seng, Elizabeth

2016-01-01

There is a need to consider the impact of the new resident-hours regulations on the variety of aspects of medical education and patient care. Most existing literature about this subject has focused on the role of fatigue in resident performance, education and healthcare delivery. However, there are other possible consequences of these new regulations, including a negative impact on decision ownership. Our main assumption of is that increased shiftwork in medicine can decrease ownership of treatment decisions and impact negatively on quality of care. We review some potential components of decision-ownership in treatment context and suggests possible ways in which the absence of decision-ownership may decrease the quality of medical decision-making. The paper opens with the definition of decision ownership and the overview of some contextual factors that may contribute to the development of ownership in medical residency. The following section discusses decision-ownership in medical care from the perspective of “diffusion of responsibility”. We will question quality of choices made within narrow decisional frames. We will also compare isolated and interrelated choices assuming that residents make more isolated decisions during their shifts. Lastly, we discuss the consequences of decreased decision-ownership impacting the delivery of healthcare. PMID:27471927

The Importance of Fostering Ownership During Medical Training.

PubMed

Dubov, Alex; Fraenkel, Liana; Seng, Elizabeth

2016-09-01

There is a need to consider the impact of the new resident-hours regulations on the variety of aspects of medical education and patient care. Most existing literature about this subject has focused on the role of fatigue in resident performance, education, and health care delivery. However, there are other possible consequences of these new regulations, including a negative impact on decision ownership. Our main assumption of is that increased shift work in medicine can decrease ownership of treatment decisions and impact negatively on quality of care. We review some potential components of decision ownership in treatment context and suggest possible ways in which the absence of decision ownership may decrease the quality of medical decision making. The article opens with the definition of decision ownership and the overview of some contextual factors that may contribute to the development of ownership in medical residency. The following section discusses decision ownership in medical care from the perspective of "diffusion of responsibility." We question the quality of choices made within narrow decisional frames. We also compare isolated and interrelated choices, assuming that residents make more isolated decisions during their shifts. Lastly, we discuss the consequences of decreased decision ownership impacting the delivery of health care.

Nutritional Aspects of Dysphagia Management.

PubMed

Gallegos, C; Brito-de la Fuente, E; Clavé, P; Costa, A; Assegehegn, G

This chapter describes the nutritional aspects of dysphagia management by starting with the definition of these two conditions (dysphagia and malnutrition) that share three main clinical characteristics: (a) their prevalence is very high, (b) they can lead to severe complications, and (c) they are frequently underrecognized and neglected conditions. From an anatomical standpoint, dysphagia can result from oropharyngeal and/or esophageal causes; from a pathophysiological perspective, dysphagia can be caused by organic or structural diseases (either benign or malignant) or diseases causing impaired physiology (mainly motility and/or perception disorders). This chapter gathers up-to-date information on the screening and diagnosis of oropharyngeal dysphagia, the consequences of dysphagia (aspiration pneumonia, malnutrition, and dehydration), and on the nutritional management of dysphagic patients. Concerning this last topic, this chapter reviews the rheological aspects of swallowing and dysphagia (including shear and elongational flows) and its influence on the characteristics of the enteral nutrition for dysphagia management (solid/semisolid foods and thickened liquids; ready-to-use oral nutritional supplements and thickening powders), with special focus on the real characteristics of the bolus after mixing with human saliva. © 2017 Elsevier Inc. All rights reserved.

Reflections on the career of Brazilian Paralympic athletes.

PubMed

Haiachi, Marcelo de Castro; Cardoso, Vinícius Denardin; Reppold, Alberto Reinaldo; Gaya, Adroaldo Cezar Araújo

2016-10-01

The proximity of the Paralympic Games Rio 2016 opens the discussion about the possibility of building a career in Paralympic sport. This study aims to present the characteristics and challenges present in the sporting career of the Brazilian Paralympic athlete. The study was structured under three main guiding topics: the different moments of Paralympic Sport, the career characteristics of paralympians and the consequences of sports results for their careers. Currently, Paralympic sports has its focus on high performance, as the constant necessity for good results is an ever present reality. The characteristics and challenges of sporting careers reveal the current situation for Brazilian Paralympic sports in all of its stages (pre-transition, transition and post-transition). Upon reflecting on the career of the Brazilian paralympic athlete a debate opens up concerning future perspectives and particularly on an understanding of the existing challenges for consolidation. Structural problems such as venues for training, lack of awareness on the part of the private sector and the non-renewal of human resources, seem to be the main obstacles for the consolidation of paralympic careers in Brazil.

Simulations in nursing practice: toward authentic leadership.

PubMed

Shapira-Lishchinsky, Orly

2014-01-01

Aim  This study explores nurses' ethical decision-making in team simulations in order to identify the benefits of these simulations for authentic leadership. Background  While previous studies have indicated that team simulations may improve ethics in the workplace by reducing the number of errors, those studies focused mainly on clinical aspects and not on nurses' ethical experiences or on the benefits of authentic leadership. Methods  Fifty nurses from 10 health institutions in central Israel participated in the study. Data about nurses' ethical experiences were collected from 10 teams. Qualitative data analysis based on Grounded Theory was applied, using the atlas.ti 5.0 software package. Findings  Simulation findings suggest four main benefits that reflect the underlying components of authentic leadership: self-awareness, relational transparency, balanced information processing and internalized moral perspective. Conclusions  Team-based simulation as a training tool may lead to authentic leadership among nurses. Implications for nursing management  Nursing management should incorporate team simulations into nursing practice to help resolve power conflicts and to develop authentic leadership in nursing. Consequently, errors will decrease, patients' safety will increase and optimal treatment will be provided. © 2012 John Wiley & Sons Ltd.

The medicalization of love and narrow and broad conceptions of human well-being.

PubMed

Nyholm, Sven

2015-07-01

Would a "medicalization" of love be a "good" or "bad" form of medicalization? In discussing this question, Earp, Sandberg, and Savulescu primarily focus on the potential positive and negative consequences of turning love into a medical issue. But it can also be asked whether there is something intrinsically regrettable about medicalizing love. It is argued here that the medicalization of love can be seen as an "evaluative category mistake": it treats a core human value (love) as if it were mainly a means to other ends (viz. physical health and hedonic well-being). It is also argued that Earp et al's closing argument (that a scientific perspective on love actually adds more value to love) can be seen as involving another evaluative category mistake: it treats an object of desire and practical interest (namely, love) as if it mainly were an object of scientific contemplation and theoretical interest. It is concluded that, to relate love to health and well-being in a more satisfying way, we should construe the latter two in broader ways, whereby love is itself a component or element of human flourishing.

Design for Verification: Using Design Patterns to Build Reliable Systems

NASA Technical Reports Server (NTRS)

Mehlitz, Peter C.; Penix, John; Koga, Dennis (Technical Monitor)

2003-01-01

Components so far have been mainly used in commercial software development to reduce time to market. While some effort has been spent on formal aspects of components, most of this was done in the context of programming language or operating system framework integration. As a consequence, increased reliability of composed systems is mainly regarded as a side effect of a more rigid testing of pre-fabricated components. In contrast to this, Design for Verification (D4V) puts the focus on component specific property guarantees, which are used to design systems with high reliability requirements. D4V components are domain specific design pattern instances with well-defined property guarantees and usage rules, which are suitable for automatic verification. The guaranteed properties are explicitly used to select components according to key system requirements. The D4V hypothesis is that the same general architecture and design principles leading to good modularity, extensibility and complexity/functionality ratio can be adapted to overcome some of the limitations of conventional reliability assurance measures, such as too large a state space or too many execution paths.

[Health on front page: a content analysis of the main Italian newspapers in two months of 2009].

PubMed

Marcantoni, C; Bressanelli, M; Orizio, G; Gelatti, U

2011-01-01

The increasing availability of health information appears to be associated with new citizen and patient behaviours and opinions, with repercussions on medicalization and the allocation of resources; consequently, the mass media's focus on health topics is greatly talked-about. 1) to verify and quantify overall health news in the main Italian newspapers, 2) to quantify the presence of the same news on the front page, 3) to identify health news types, and 4) highlight the tone of the headlines. The July and November 2009 issues of the Italian newspapers with the highest circulations were taken into consideration. Most of the newspapers published at least one health item per issue; each day at least one daily paper showed some news concerning health; more than 10% of these items appeared on the front page. A negative connotation was found in more than 50% of the headlines. Health was confirmed as a leading topic, and a constant presence in everyday life in Italy. The number of health news items was higher in November probably as a result of the H1N1 flu virus.

Obesity and weight management in the elderly: a focus on men.

PubMed

Han, T S; Wu, F C W; Lean, M E J

2013-08-01

The rising rate of overweight/obesity among the ever-growing ageing population is imposing massive and rapidly changing burdens of ill health. The observation that the BMI value associated with the lowest relative mortality is slightly higher in older than in younger adults, mainly through its reduced impact on coronary heart disease, has often been misinterpreted that obesity is not as harmful in the elderly, who suffer a large range of disabling consequences of obesity. All medical consequences of obesity are multi-factorial and most alleviated by modest, achievable weight loss (5-10 kg) with an evidence-based maintenance strategy. But severe obesity, e.g. BMI >40 may demand greater weight loss e.g. >15 kg to reverse type 2 diabetes. Since relatively reduced physical activity and reduced muscle mass (sarcopenic obesity) are common in the elderly, combining exercise and modest calorie restriction optimally reduces fat mass and preserves muscle mass - age presents no obstacle and reducing polypharmacy is a valuable outcome. The currently licensed drug orlistat has no age-related hazards and is effective in a low fat diet, but the risks from bariatric surgery begin to outweigh benefits above age 60. For the growing numbers of obese elderly with diabetes, the glucagon-like peptide-1 (GLP-1) receptor analogue liraglutide appears a safe way to promote and maintain substantial weight loss. Obesity and sarcopenia should be prevented from younger age and during life-transitions including retiral to improve future health outcomes and quality of life, with a focus on those in "obese families". Copyright © 2013 Elsevier Ltd. All rights reserved.

Chernobyl and Goiânia lessons for responding to radiological terrorism.

PubMed

Steinhausler, Friedrich

2005-11-01

The deployment of a radiological dispersal device (RDD) is likely to result in relatively low radiation exposure of the targeted population, insufficient to cause a severe radiation detriment. Nevertheless, due to atmospheric dispersion of the radioactive material, an urban area equaling several city blocks could be affected. The current knowledge base concerning the response to radiological terrorism, focusing mainly on environmental cleanup and site recovery (CSR) of areas with radioactive contamination due to the deployment of an RDD, is largely derived from military scientific tests or exercises assembled over the past 50 y with only limited applicability to the consequences of an RDD detonating in a city. This paper focuses on the extensive experience in CSR gained in the management of the radiological accident contaminating the Brazilian city of Goiânia in 1987, and managing the aftermath of the Chernobyl reactor accident in 1986. The incident in Goiânia demonstrated the numerous practical difficulties of implementing a sound CSR, based on a balanced judgment of all relevant factors, such as radiation safety, environmental issues, economic consequences, and public fear. A review of the different stages of the intervention policy in the former Soviet Union reveals that risk-benefit cost analysis was not used for the decision-making process during the later stages of the post-accident situation. Instead, a CSR policy was adopted that resulted in continuously escalating costs. The results of this analysis are used to develop an Integrated Cleanup and Site Restoration Concept and recommend practically applicable solutions from Lessons Learned.

A preliminary taxonomy of medical errors in family practice

PubMed Central

Dovey, S; Meyers, D; Phillips, R; Green, L; Fryer, G; Galliher, J; Kappus, J; Grob, P

2002-01-01

Objective: To develop a preliminary taxonomy of primary care medical errors. Design: Qualitative analysis to identify categories of error reported during a randomized controlled trial of computer and paper reporting methods. Setting: The National Network for Family Practice and Primary Care Research. Participants: Family physicians. Main outcome measures: Medical error category, context, and consequence. Results: Forty two physicians made 344 reports: 284 (82.6%) arose from healthcare systems dysfunction; 46 (13.4%) were errors due to gaps in knowledge or skills; and 14 (4.1%) were reports of adverse events, not errors. The main subcategories were: administrative failures (102; 30.9% of errors), investigation failures (82; 24.8%), treatment delivery lapses (76; 23.0%), miscommunication (19; 5.8%), payment systems problems (4; 1.2%), error in the execution of a clinical task (19; 5.8%), wrong treatment decision (14; 4.2%), and wrong diagnosis (13; 3.9%). Most reports were of errors that were recognized and occurred in reporters' practices. Affected patients ranged in age from 8 months to 100 years, were of both sexes, and represented all major US ethnic groups. Almost half the reports were of events which had adverse consequences. Ten errors resulted in patients being admitted to hospital and one patient died. Conclusions: This medical error taxonomy, developed from self-reports of errors observed by family physicians during their routine clinical practice, emphasizes problems in healthcare processes and acknowledges medical errors arising from shortfalls in clinical knowledge and skills. Patient safety strategies with most effect in primary care settings need to be broader than the current focus on medication errors. PMID:12486987

Neurobiology of autism gene products: towards pathogenesis and drug targets.

PubMed

Kleijer, Kristel T E; Schmeisser, Michael J; Krueger, Dilja D; Boeckers, Tobias M; Scheiffele, Peter; Bourgeron, Thomas; Brose, Nils; Burbach, J Peter H

2014-03-01

The genetic heterogeneity of autism spectrum disorders (ASDs) is enormous, and the neurobiology of proteins encoded by genes associated with ASD is very diverse. Revealing the mechanisms on which different neurobiological pathways in ASD pathogenesis converge may lead to the identification of drug targets. The main objective is firstly to outline the main molecular networks and neuronal mechanisms in which ASD gene products participate and secondly to answer the question how these converge. Finally, we aim to pinpoint drug targets within these mechanisms. Literature review of the neurobiological properties of ASD gene products with a special focus on the developmental consequences of genetic defects and the possibility to reverse these by genetic or pharmacological interventions. The regulation of activity-dependent protein synthesis appears central in the pathogenesis of ASD. Through sequential consequences for axodendritic function, neuronal disabilities arise expressed as behavioral abnormalities and autistic symptoms in ASD patients. Several known ASD gene products have their effect on this central process by affecting protein synthesis intrinsically, e.g., through enhancing the mammalian target of rapamycin (mTOR) signal transduction pathway or through impairing synaptic function in general. These are interrelated processes and can be targeted by compounds from various directions: inhibition of protein synthesis through Lovastatin, mTOR inhibition using rapamycin, or mGluR-related modulation of synaptic activity. ASD gene products may all feed into a central process of translational control that is important for adequate glutamatergic regulation of dendritic properties. This process can be modulated by available compounds but may also be targeted by yet unexplored routes.

Functional metagenomics of oil-impacted mangrove sediments reveals high abundance of hydrolases of biotechnological interest.

PubMed

Ottoni, Júlia Ronzella; Cabral, Lucélia; de Sousa, Sanderson Tarciso Pereira; Júnior, Gileno Vieira Lacerda; Domingos, Daniela Ferreira; Soares Junior, Fábio Lino; da Silva, Mylenne Calciolari Pinheiro; Marcon, Joelma; Dias, Armando Cavalcante Franco; de Melo, Itamar Soares; de Souza, Anete Pereira; Andreote, Fernando Dini; de Oliveira, Valéria Maia

2017-07-01

Mangroves are located in coastal wetlands and are susceptible to the consequences of oil spills, what may threaten the diversity of microorganisms responsible for the nutrient cycling and the consequent ecosystem functioning. Previous reports show that high concentration of oil favors the incidence of epoxide hydrolases and haloalkane dehalogenases in mangroves. This finding has guided the goals of this study in an attempt to broaden the analysis to other hydrolases and thereby verify whether oil contamination interferes with the prevalence of particular hydrolases and their assigned microorganisms. For this, an in-depth survey of the taxonomic and functional microbial diversity recovered in a fosmid library (Library_Oil Mgv) constructed from oil-impacted Brazilian mangrove sediment was carried out. Fosmid DNA of the whole library was extracted and submitted to Illumina HiSeq sequencing. The resulting Library Oil_Mgv dataset was further compared with those obtained by direct sequencing of environmental DNA from Brazilian mangroves (from distinct regions and affected by distinct sources of contamination), focusing on hydrolases with potential use in biotechnological processes. The most abundant hydrolases found were proteases, esterases and amylases, with similar occurrence profile in all datasets. The main microbial groups harboring such hydrolase-encoding genes were distinct in each mangrove, and in the fosmid library these enzymes were mainly assigned to Chloroflexaceae (for amylases), Planctomycetaceae (for esterases) and Bradyrhizobiaceae (for proteases). Assembly and analysis of Library_Oil Mgv reads revealed three potentially novel enzymes, one epoxide hydrolase, one xylanase and one amylase, to be further investigated via heterologous expression assays.

When gender bumps into health and safety training: working conditions, readings and challenges drawn from a case study in an industrial chemicals company.

PubMed

Vasconcelos, Ricardo; Teixeira, Sandra; Castelhano, Joana; Lacomblez, Marianne

2012-01-01

Health, safety and environmental issues are at present a social concern and an increasingly referred topic in the so called gender studies. This paper focuses on the relations between training, gender and risk perception in an industrial chemicals company, in Portugal, characterized by a mainly male population and by the presence of high occupational and environmental hazards. After characterizing the company and the training project that started up this reflection, the paper presents the reasons for its focus on gender followed by the essential methodological explanations: 14 interviews were made with male and female workers from the company; their content was transcribed from the audio recordings and it was systematically analyzed. A gender-attentive socio demographic analysis was also undertaken. Although at the beginning the company did not consider the gender issues as a problem nor was it the central topic of the training, which focused on the prevention of occupational and environmental hazards, the results reveal that the gender factor brought to light some working conditions, which so far have not been properly discussed within the group meetings. As a consequence, there is now room for the transformation of the representations on those working conditions.

Adult Attachment and Transgender Identity in the Italian Context: Clinical Implications and Suggestions for Further Research

PubMed Central

Amodeo, Anna Lisa; Vitelli, Roberto; Scandurra, Cristiano; Picariello, Simona; Valerio, Paolo

2016-01-01

Introduction Although attachment theory has been recognized as one of the main reference for the study of the general wellbeing, little research has been focused on the attachment styles of transgender people. Attachment styles are deeply influenced by the earliest relationships with caregivers, which, for gender nonconforming children, are often characterized by parental rejection. Consequently, transgender children and adults likely internalize societal stigma, developing internalized transphobia. The current research was aimed to explore the link between adult attachment and internalized transphobia. Method 25 male-to-female (MtF) and 23 female-to-male (FtM) transgender people participated in the survey filling in two self-report questionnaires: the Attachment Style Questionnaire and the Transgender Identity Survey. A cluster analysis, T-Test and multiple regression analysis were conducted to explore the link between attachment styles and internalized transphobia. Results A greater prevalence of secure attachment styles was detected. Participants with secure attachment styles reported higher levels of positive transgender identity than those with insecure attachment styles. Secure attachment styles significantly affect positive transgender identity, while insecure attachment styles influence internalized transphobia. Conclusions A clinical focus on the redefinition of the Internal Working Models of transgender people can inform psychologically-focused interventions, which transgender people can benefit from. PMID:26937224

Sulcal depth-based cortical shape analysis in normal healthy control and schizophrenia groups

NASA Astrophysics Data System (ADS)

Lyu, Ilwoo; Kang, Hakmook; Woodward, Neil D.; Landman, Bennett A.

2018-03-01

Sulcal depth is an important marker of brain anatomy in neuroscience/neurological function. Previously, sulcal depth has been explored at the region-of-interest (ROI) level to increase statistical sensitivity to group differences. In this paper, we present a fully automated method that enables inferences of ROI properties from a sulcal region- focused perspective consisting of two main components: 1) sulcal depth computation and 2) sulcal curve-based refined ROIs. In conventional statistical analysis, the average sulcal depth measurements are employed in several ROIs of the cortical surface. However, taking the average sulcal depth over the full ROI blurs overall sulcal depth measurements which may result in reduced sensitivity to detect sulcal depth changes in neurological and psychiatric disorders. To overcome such a blurring effect, we focus on sulcal fundic regions in each ROI by filtering out other gyral regions. Consequently, the proposed method results in more sensitive to group differences than a traditional ROI approach. In the experiment, we focused on a cortical morphological analysis to sulcal depth reduction in schizophrenia with a comparison to the normal healthy control group. We show that the proposed method is more sensitivity to abnormalities of sulcal depth in schizophrenia; sulcal depth is significantly smaller in most cortical lobes in schizophrenia compared to healthy controls (p < 0.05).

Occurrence and effects of plastic additives on marine environments and organisms: A review.

PubMed

Hermabessiere, Ludovic; Dehaut, Alexandre; Paul-Pont, Ika; Lacroix, Camille; Jezequel, Ronan; Soudant, Philippe; Duflos, Guillaume

2017-09-01

Plastics debris, especially microplastics, have been found worldwide in all marine compartments. Much research has been carried out on adsorbed pollutants on plastic pieces and hydrophobic organic compounds (HOC) associated with microplastics. However, only a few studies have focused on plastic additives. These chemicals are incorporated into plastics from which they can leach out as most of them are not chemically bound. As a consequence of plastic accumulation and fragmentation in oceans, plastic additives could represent an increasing ecotoxicological risk for marine organisms. The present work reviewed the main class of plastic additives identified in the literature, their occurrence in the marine environment, as well as their effects on and transfers to marine organisms. This work identified polybrominated diphenyl ethers (PBDE), phthalates, nonylphenols (NP), bisphenol A (BPA) and antioxidants as the most common plastic additives found in marine environments. Moreover, transfer of these plastic additives to marine organisms has been demonstrated both in laboratory and field studies. Upcoming research focusing on the toxicity of microplastics should include these plastic additives as potential hazards for marine organisms, and a greater focus on the transport and fate of plastic additives is now required considering that these chemicals may easily leach out from plastics. Copyright © 2017 Elsevier Ltd. All rights reserved.

“Bad boys don't cry”: a thematic analysis of interpersonal dynamics in interview narratives of young offenders with psychopathic traits

PubMed Central

De Ganck, Julie; Vanheule, Stijn

2015-01-01

Most discussions of the social and interpersonal styles in individuals with strong psychopathic traits focus on their dangerousness or their affective and interpersonal deficiencies. This study has a different focus, and starts from the idea that such focus on the threat emanating from individuals with a psychopathic style might blind us from the logic inherent to their way of relating with the world. By means of a qualitative analysis (thematic analysis) of narratives from a Lacanian talking therapy, this study examines how 15 youngsters with strong psychopathic traits make sense of interpersonal events and relations. The main recurring theme across these narratives was that others in general are fundamentally distrustful antagonists that they have to protect themselves from. Especially the father figure, with whom identification seems to take place, is seen as a violent actor. Consequently, these youngsters develop multiple strategies of dealing with the threat they experience in relation to (significant) others. These relationship patterns also emerged within the therapeutic relationship, resulting in frequent testing of the therapist's trustworthiness. The results of this study, discussed in terms of Lacanian theory, might help therapists to develop treatment approaches that better fit with the interpersonal orientation of individuals with strong psychopathic traits. PMID:26217279

[Bacterial vaginosis].

PubMed

Romero Herrero, Daniel; Andreu Domingo, Antonia

2016-07-01

Bacterial vaginosis (BV) is the main cause of vaginal dysbacteriosis in the women during the reproductive age. It is an entity in which many studies have focused for years and which is still open for discussion topics. This is due to the diversity of microorganisms that cause it and therefore, its difficult treatment. Bacterial vaginosis is probably the result of vaginal colonization by complex bacterial communities, many of them non-cultivable and with interdependent metabolism where anaerobic populations most likely play an important role in its pathogenesis. The main symptoms are an increase of vaginal discharge and the unpleasant smell of it. It can lead to serious consequences for women, such as an increased risk of contracting sexually transmitted infections including human immunodeficiency virus and upper genital tract and pregnancy complications. Gram stain is the gold standard for microbiological diagnosis of BV, but can also be diagnosed using the Amsel clinical criteria. It should not be considered a sexually transmitted disease but it is highly related to sex. Recurrence is the main problem of medical treatment. Apart from BV, there are other dysbacteriosis less characterized like aerobic vaginitis of which further studies are coming slowly but are achieving more attention and consensus among specialists. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis

PubMed Central

Mavragani, Ifigeneia V.; Nikitaki, Zacharenia; Souli, Maria P.; Aziz, Asef; Nowsheen, Somaira; Aziz, Khaled; Rogakou, Emmy

2017-01-01

Cellular effects of ionizing radiation (IR) are of great variety and level, but they are mainly damaging since radiation can perturb all important components of the cell, from the membrane to the nucleus, due to alteration of different biological molecules ranging from lipids to proteins or DNA. Regarding DNA damage, which is the main focus of this review, as well as its repair, all current knowledge indicates that IR-induced DNA damage is always more complex than the corresponding endogenous damage resulting from endogenous oxidative stress. Specifically, it is expected that IR will create clusters of damage comprised of a diversity of DNA lesions like double strand breaks (DSBs), single strand breaks (SSBs) and base lesions within a short DNA region of up to 15–20 bp. Recent data from our groups and others support two main notions, that these damaged clusters are: (1) repair resistant, increasing genomic instability (GI) and malignant transformation and (2) can be considered as persistent “danger” signals promoting chronic inflammation and immune response, causing detrimental effects to the organism (like radiation toxicity). Last but not least, the paradigm shift for the role of radiation-induced systemic effects is also incorporated in this picture of IR-effects and consequences of complex DNA damage induction and its erroneous repair. PMID:28718816

Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis.

PubMed

Mavragani, Ifigeneia V; Nikitaki, Zacharenia; Souli, Maria P; Aziz, Asef; Nowsheen, Somaira; Aziz, Khaled; Rogakou, Emmy; Georgakilas, Alexandros G

2017-07-18

Cellular effects of ionizing radiation (IR) are of great variety and level, but they are mainly damaging since radiation can perturb all important components of the cell, from the membrane to the nucleus, due to alteration of different biological molecules ranging from lipids to proteins or DNA. Regarding DNA damage, which is the main focus of this review, as well as its repair, all current knowledge indicates that IR-induced DNA damage is always more complex than the corresponding endogenous damage resulting from endogenous oxidative stress. Specifically, it is expected that IR will create clusters of damage comprised of a diversity of DNA lesions like double strand breaks (DSBs), single strand breaks (SSBs) and base lesions within a short DNA region of up to 15-20 bp. Recent data from our groups and others support two main notions, that these damaged clusters are: (1) repair resistant, increasing genomic instability (GI) and malignant transformation and (2) can be considered as persistent "danger" signals promoting chronic inflammation and immune response, causing detrimental effects to the organism (like radiation toxicity). Last but not least, the paradigm shift for the role of radiation-induced systemic effects is also incorporated in this picture of IR-effects and consequences of complex DNA damage induction and its erroneous repair.

From Planetary Mapping to Map Production: Planetary Cartography as integral discipline in Planetary Sciences

NASA Astrophysics Data System (ADS)

Nass, Andrea; van Gasselt, Stephan; Hargitai, Hendrik; Hare, Trent; Manaud, Nicolas; Karachevtseva, Irina; Kersten, Elke; Roatsch, Thomas; Wählisch, Marita; Kereszturi, Akos

2016-04-01

Cartography is one of the most important communication channels between users of spatial information and laymen as well as the open public alike. This applies to all known real-world objects located either here on Earth or on any other object in our Solar System. In planetary sciences, however, the main use of cartography resides in a concept called planetary mapping with all its various attached meanings: it can be (1) systematic spacecraft observation from orbit, i.e. the retrieval of physical information, (2) the interpretation of discrete planetary surface units and their abstraction, or it can be (3) planetary cartography sensu strictu, i.e., the technical and artistic creation of map products. As the concept of planetary mapping covers a wide range of different information and knowledge levels, aims associated with the concept of mapping consequently range from a technical and engineering focus to a scientific distillation process. Among others, scientific centers focusing on planetary cartography are the United State Geological Survey (USGS, Flagstaff), the Moscow State University of Geodesy and Cartography (MIIGAiK, Moscow), Eötvös Loránd University (ELTE, Hungary), and the German Aerospace Center (DLR, Berlin). The International Astronomical Union (IAU), the Commission Planetary Cartography within International Cartographic Association (ICA), the Open Geospatial Consortium (OGC), the WG IV/8 Planetary Mapping and Spatial Databases within International Society for Photogrammetry and Remote Sensing (ISPRS) and a range of other institutions contribute on definition frameworks in planetary cartography. Classical cartography is nowadays often (mis-)understood as a tool mainly rather than a scientific discipline and an art of communication. Consequently, concepts of information systems, mapping tools and cartographic frameworks are used interchangeably, and cartographic workflows and visualization of spatial information in thematic maps have often been neglected or were left to software systems to decide by some arbitrary default values. The diversity of cartography as a research discipline and its different contributions in geospatial sciences and communication of information and knowledge will be highlighted in this contribution. We invite colleagues from this and other discipline to discuss concepts and topics for joint future collaboration and research.

Physical therapy in the treatment of fibromyalgia.

PubMed

Offenbächer, M; Stucki, G

2000-01-01

Fibromyalgia (FM) is a syndrome of unknown etiology characterized by chronic wide spread pain, increased tenderness to palpation and additional symptoms such as disturbed sleep, stiffness, fatigue and psychological distress. While medication mainly focus on pain reduction, physical therapy is aimed at disease consequences such as pain, fatigue, deconditioning, muscle weakness and sleep disturbances and other disease consequences. We systematically reviewed current treatment options in the treatment of fibromyalgia. Based on evidence from randomized controlled trials cardiovascular fitness training importantly improves cardiovascular fitness, both subjective and objective measures of pain as well as subjective energy and work capacity and physical and social activities. Based on anecdotal evidence or small observational studies physiotherapy may reduce overloading of the muscle system, improve postural fatigue and positioning, and condition weak muscles. Modalities and whole body cryotherapy may reduce localized as well as generalized pain in short term. Trigger point injection may reduce pain originating from concomitant trigger points in selected FM patient. Massage may reduce muscle tension and may be prescribed as a adjunct with other therapeutic interventions. Acupuncture may reduce pain and increase pain threshold. Biofeedback may positively influence subjective and objective disease measures. TENS may reduce localized musculoskeletal pain in fibromyalgia. While there seems to be no single best treatment option, physical therapy seem to reduce disease consequences. Accordingly a multidisciplinary approach combining these therapies in a well balanced program may be the most promising strategy and is currently recommended in the treatment of fibromyalgia.

[Andrologic consequences of chronic renal failure: State of the art for the yearly scientific report of the French National Association of Urology].

PubMed

Neuzillet, Y; Thuret, R; Kleinclauss, F; Timsit, M-O

2016-11-01

To describe the state of the art of current knowledge regarding gonadal consequences of end-stage chronic kidney disease (CKD) and renal transplantation. A systematic review of the literature search was performed from the databases Medline (NLM, Pubmed) and Embase, focused on the following keywords: "chronic kidney disease"; "chronic renal failure"; "hypogonadism"; "kidney transplantation"; "testicular dysfunction"; "testosterone". Publications obtained were selected based on methodology, language, date of publication (last 10 years) and relevance. Prospective and retrospective studies, in English or French, review articles; meta-analysis and guidelines were selected and analyzed. This search found 383 articles. After reading titles and abstracts, 51 were included in the text, based on their relevance. The prevalence of hypogonadism in CKD is reported between 24 % and 66 %, and decreases partially after renal transplantation. This is a hypogonadotropic hypogonadism whose pathophysiology is multifactorial, involving mainly a primitive testicular deficit, a hypothalamic-pituitary dysregulation, and an hyperprolactinemia. The consequences of this hypogonadism are not only sexual but also contribute to anemia, sarcopenia, atherosclerosis, and potentially in the progression of CKD. Hypogonadism is an independent risk factor for mortality in CKD patients. CKD is frequently associated with an hypogonadism whose correction is validated only in the setting of erectile dysfunction treatment. The other benefits of the correction of hypogonadism in the CKD patients, including overall survival, needs to be evaluated. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

A hybrid learning method for constructing compact rule-based fuzzy models.

PubMed

Zhao, Wanqing; Niu, Qun; Li, Kang; Irwin, George W

2013-12-01

The Takagi–Sugeno–Kang-type rule-based fuzzy model has found many applications in different fields; a major challenge is, however, to build a compact model with optimized model parameters which leads to satisfactory model performance. To produce a compact model, most existing approaches mainly focus on selecting an appropriate number of fuzzy rules. In contrast, this paper considers not only the selection of fuzzy rules but also the structure of each rule premise and consequent, leading to the development of a novel compact rule-based fuzzy model. Here, each fuzzy rule is associated with two sets of input attributes, in which the first is used for constructing the rule premise and the other is employed in the rule consequent. A new hybrid learning method combining the modified harmony search method with a fast recursive algorithm is hereby proposed to determine the structure and the parameters for the rule premises and consequents. This is a hard mixed-integer nonlinear optimization problem, and the proposed hybrid method solves the problem by employing an embedded framework, leading to a significantly reduced number of model parameters and a small number of fuzzy rules with each being as simple as possible. Results from three examples are presented to demonstrate the compactness (in terms of the number of model parameters and the number of rules) and the performance of the fuzzy models obtained by the proposed hybrid learning method, in comparison with other techniques from the literature.

The macroeconomic consequences of renouncing to universal access to antiretroviral treatment for HIV in Africa: a micro-simulation model.

PubMed

Ventelou, Bruno; Arrighi, Yves; Greener, Robert; Lamontagne, Erik; Carrieri, Patrizia; Moatti, Jean-Paul

2012-01-01

Previous economic literature on the cost-effectiveness of antiretroviral treatment (ART) programs has been mainly focused on the microeconomic consequences of alternative use of resources devoted to the fight against the HIV pandemic. We rather aim at forecasting the consequences of alternative scenarios for the macroeconomic performance of countries. We used a micro-simulation model based on individuals aged 15-49 selected from nationally representative surveys (DHS for Cameroon, Tanzania and Swaziland) to compare alternative scenarios : 1-freezing of ART programs to current levels of access, 2- universal access (scaling up to 100% coverage by 2015, with two variants defining ART eligibility according to previous or current WHO guidelines). We introduced an "artificial" ageing process by programming methods. Individuals could evolve through different health states: HIV negative, HIV positive (with different stages of the syndrome). Scenarios of ART procurement determine this dynamics. The macroeconomic impact is obtained using sample weights that take into account the resulting age-structure of the population in each scenario and modeling of the consequences on total growth of the economy. Increased levels of ART coverage result in decreasing HIV incidence and related mortality. Universal access to ART has a positive impact on workers' productivity; the evaluations performed for Swaziland and Cameroon show that universal access would imply net cost-savings at the scale of the society, when the full macroeconomic consequences are introduced in the calculations. In Tanzania, ART access programs imply a net cost for the economy, but 70% of costs are covered by GDP gains at the 2034 horizon, even in the extended coverage option promoted by WHO guidelines initiating ART at levels of 350 cc/mm(3) CD4 cell counts. Universal Access ART scaling-up strategies, which are more costly in the short term, remain the best economic choice in the long term. Renouncing or significantly delaying the achievement of this goal, due to "legitimate" short term budgetary constraints would be a misguided choice.

Deliberations about a perfect storm - The meaning of justice for food energy water-nexus (FEW-Nexus).

PubMed

Schlör, Holger; Venghaus, Sandra; Fischer, Wiltrud; Märker, Carolin; Hake, Jürgen-Friedrich

2018-08-15

The current global developments have the potential to cause a 'perfect storm' at the core of the Anthropocene: the Food-Energy-Water-Nexus. To discuss the ethical consequences of these developments, i.e., insufficient access to the life sustaining nexus resources, the analysis is focused on Rawls' theory of justice and its implementation in Germany with a special focus on the FEW nexus. Rawls stresses in his theory of justice the prominent meaning of institutions for a fair society to meet societal challenges and to meet the challenge of our time: a stable and just society. Hence, the realization of his ideas in Germany is scrutinized and income tax and value added tax are interpreted in the sense of Douglas North and John Rawls as institutions and formal rules of society. This paper focuses on taxes as the most important institutional incentive to organize and structure the political, social and economic cooperation and analyses how these incentives affect selected German households (all households, singles, single man and woman, and couples) with respect to income and FEW expenditures. The relevant income and usage data sample (Einkommens- und Verbrauchsstichprobe (EVS)) for Germany is used for the analysis of the distribution of income types, FEW expenditures and the revenues of income tax and value added tax, i.e., the main instruments to manage the challenges of the FEW nexus. Therefore two distribution measures have been used: the dispersion of income, taxes and FEW expenditures and their skewness. Five household groups were selected for this analysis: All households, all single households, the single women households, the single men households, as well as the households of couples. The EVS data sample allows the analysis of consequences of the current societal conditions on the various households and thus serves to provide a deeper understanding of the differences between singles and couples but also between single women and men. Copyright © 2018 Elsevier Ltd. All rights reserved.

Effects of nanomaterials on marine invertebrates.

PubMed

Canesi, Laura; Corsi, Ilaria

2016-09-15

The development of nanotechnology will inevitably lead to the release of consistent amounts of nanomaterials (NMs) and nanoparticles (NPs) into marine ecosystems. Ecotoxicological studies have been carried out to identify potential biological targets of NPs, and suitable models for predicting their impact on the health of the marine environment. Recent studies in invertebrates mainly focused on NP accumulation and sub-lethal effects, rather than acute toxicity. Among marine invertebrates, bivalves represent by large the most studied group, with polychaetes and echinoderms also emerging as significant targets of NPs. However, major scientific gaps still need to be filled. In this work, factors affecting the fate of NPs in the marine environment, and their consequent uptake/accumulation/toxicity in marine invertebrates will be summarized. The results show that in different model species, NP accumulation mainly occurs in digestive tract and gills. Data on sub-lethal effects and modes of action of different types of NPs (mainly metal oxides and metal based NPs) in marine invertebrates will be reviewed, in particular on immune function, oxidative stress and embryo development. Moreover, the possibility that such effects may be influenced by NP interactions with biomolecules in both external and internal environment will be introduced. In natural environmental media, NP interactions with polysaccharides, proteins and colloids may affect their agglomeration/aggregation and consequent bioavailability. Moreover, once within the organism, NPs are known to interact with plasma proteins, forming a protein corona that can affect particle uptake and toxicity in target cells in a physiological environment. These interactions, leading to the formation of eco-bio-coronas, may be crucial in determining particle behavior and effects also in marine biota. In order to classify NPs into groups and predict the implications of their release into the marine environment, information on their intrinsic properties is clearly insufficient, and a deeper understanding of NP eco/bio-interactions is required. Copyright © 2016 Elsevier B.V. All rights reserved.

Troubled Waters: Navigating Unintended Consequences of Health Information Technology.

PubMed

Lehmann, C U; Séroussi, B; Jaulent, M-C

2016-11-10

To provide an introduction to the 2016 IMIA Yearbook of Medical Informatics by the editors. We present a brief overview of the 2016 special topic "Unintended consequences of Health IT: new problems, new solutions", we review our choice of special topic section editors, and discuss the transitions in the editorial team for next year. This edition of the Yearbook acknowledges the fact that implementation and use of Health Information Technology (HIT) may result in unintended consequences, which may lead to both adverse and sometimes beneficial outcomes. However to date, in the literature, undesired outcomes are emphasized with a focus on the complex causes and the many sources that may generate them. The growing awareness of the importance of HIT's unintended consequences and their increasing documentation reflect a wider acceptance of HIT by users (more use generating more consequences) and and a new type of users (a shift from early adopters to late adopters and laggards), whith great expectations regarding the improvement of care quality through HIT solutions. Different points of view on new problems and new solutions of unintended consequences of Health IT are presented through the keynote paper, survey papers, and the working group contributions. The regular 2016 issue of the IMIA yearbook focuses on new unintended consequences of Health IT - brought on by wider adoption and different types of users as well as solutions to addressing them.

Consequences of Incorrect Focus Cues in Stereo Displays

PubMed Central

Banks, Martin S.; Akeley, Kurt; Hoffman, David M.; Girshick, Ahna R.

2010-01-01

Conventional stereo displays produce images in which focus cues – blur and accommodation – are inconsistent with the simulated depth. We have developed new display techniques that allow the presentation of nearly correct focus. Using these techniques, we find that stereo vision is faster and more accurate when focus cues are mostly consistent with simulated depth; furthermore, viewers experience less fatigue when focus cues are correct or nearly correct. PMID:20523910

International Large-Scale Assessments: What Uses, What Consequences?

ERIC Educational Resources Information Center

Johansson, Stefan

2016-01-01

Background: International large-scale assessments (ILSAs) are a much-debated phenomenon in education. Increasingly, their outcomes attract considerable media attention and influence educational policies in many jurisdictions worldwide. The relevance, uses and consequences of these assessments are often the focus of research scrutiny. Whilst some…

EMP/GMD Phase 0 Report, A Review of EMP Hazard Environments and Impacts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rivera, Michael Kelly; Backhaus, Scott N.; Woodroffe, Jesse Richard

The purpose of this study is to determine methods to analyze the hazard environments, impacts, and consequences of different sources of electromagnetic pulse (EMP), including nuclear electromagnetic pulse (NEMP) and geomagnetic disturbance (GMD) on the U.S. electric power infrastructures and to use those methods to determine EMP and GMD events of concern. The study will be carried out in four phases, each of which will provide higher levels of analytic fidelity that focuses on those EMP/GMD sources and events that create significant consequences, or whose consequences are sufficiently uncertain, to require more in-depth study. This study will leverage the bestmore » experimental data; device, equipment and system models; and simulation tools currently available. This study focuses primarily on the bulk electric system (BES) including large generating stations, large power transformers, the transmission network, and transmission system protection. Electrical distribution systems may potentially be included, if warranted, after consideration of the consequences for the bulk power system.« less

Engineering solid-state materials. Strategies for modeling and packing control of molecular assemblies into 3-D networks

NASA Astrophysics Data System (ADS)

Videnova-Adrabinska, V.; Etter, M. C.; Ward, M. D.

1993-04-01

The crystal structure and properties of a number of urea cocrystals are studied with regard to symmetry of the hydrogen-bonded molecular assemblies. The logical consequences of hydrogen bonding interactions are followed step-by-step. The problems of aggregate formation, nucleation, and crystal growth are also elucidated. Endeavor is made to envisage the 2-D and 3-D hydrogen bond network in a manageable way by exploiting graph set short hand. Strategies of how to control the symmetry of molecular packing are still to be elaborated. In our strategy, the programmed self-assembly has been based on the principle of molecular recognition of self- and hetero-complementary functional groups. However, the main focus for pre-organizational control has been put on the two-fold axis estimator of the urea molecule.

Multiphase and multiscale approaches for modelling the injection of textured moulds

NASA Astrophysics Data System (ADS)

Nakhoul, Rebecca; Laure, Patrice; Silva, Luisa; Vincent, Michel

2016-10-01

Micro-injection moulding is frequently used for the mass production of devices in micro-medical technologies, micro-optics and micro-mechanics. This work focuses mainly on offering numerical tools to model the injection of micro-textured moulds. Such tools can predict the different filling scenarios of the micro-details and consequently offer optimal operating conditions (mould and melt temperatures, melt flow, stresses, etc.) to analyse the final part quality. To do so, a full Eulerian approach is used to model the injection of textured moulds at both the macroscopic and microscopic scales as usual industrial software cannot handle the filling of micro details. Since heat transfers with the mould are very relevant due to high cooling rates, the coupling between micro- and macro- simulations is primordial to insure a complete and accurate representation of textured mould injection.

Methyl esterification of pectin plays a role during plant-pathogen interactions and affects plant resistance to diseases.

PubMed

Lionetti, Vincenzo; Cervone, Felice; Bellincampi, Daniela

2012-11-01

The cell wall is a complex structure mainly composed by a cellulose-hemicellulose network embedded in a cohesive pectin matrix. Pectin is synthesized in a highly methyl esterified form and is de-esterified in muro by pectin methyl esterases (PMEs). The degree and pattern of methyl esterification affect the cell wall structure and properties with consequences on both the physiological processes of the plants and their resistance to pathogens. PME activity displays a crucial role in the outcome of the plant-pathogen interactions by making pectin more susceptible to the action of the enzymes produced by the pathogens. This review focuses on the impact of pectin methyl esterification in plant-pathogen interactions and on the dynamic role of its alteration during pathogenesis. Copyright © 2012 Elsevier GmbH. All rights reserved.

Updated Overview of Infrared Spectroscopy Methods for Detecting Mycotoxins on Cereals (Corn, Wheat, and Barley)

PubMed Central

2018-01-01

Each year, mycotoxins cause economic losses of several billion US dollars worldwide. Consequently, methods must be developed, for producers and cereal manufacturers, to detect these toxins and to comply with regulations. Chromatographic reference methods are time consuming and costly. Thus, alternative methods such as infrared spectroscopy are being increasingly developed to provide simple, rapid, and nondestructive methods to detect mycotoxins. This article reviews research conducted over the last eight years into the use of near-infrared and mid-infrared spectroscopy to monitor mycotoxins in corn, wheat, and barley. More specifically, we focus on the Fusarium species and on the main fusariotoxins of deoxynivalenol, zearalenone, and fumonisin B1 and B2. Quantification models are insufficiently precise to satisfy the legal requirements. Sorting models with cutoff levels are the most promising applications. PMID:29320435

Updated Overview of Infrared Spectroscopy Methods for Detecting Mycotoxins on Cereals (Corn, Wheat, and Barley).

PubMed

Levasseur-Garcia, Cecile

2018-01-10

Each year, mycotoxins cause economic losses of several billion US dollars worldwide. Consequently, methods must be developed, for producers and cereal manufacturers, to detect these toxins and to comply with regulations. Chromatographic reference methods are time consuming and costly. Thus, alternative methods such as infrared spectroscopy are being increasingly developed to provide simple, rapid, and nondestructive methods to detect mycotoxins. This article reviews research conducted over the last eight years into the use of near-infrared and mid-infrared spectroscopy to monitor mycotoxins in corn, wheat, and barley. More specifically, we focus on the Fusarium species and on the main fusariotoxins of deoxynivalenol, zearalenone, and fumonisin B1 and B2. Quantification models are insufficiently precise to satisfy the legal requirements. Sorting models with cutoff levels are the most promising applications.

Marine copepod cytochrome P450 genes and their applications for molecular ecotoxicological studies in response to oil pollution.

PubMed

Han, Jeonghoon; Won, Eun-Ji; Kang, Hye-Min; Lee, Min-Chul; Jeong, Chang-Bum; Kim, Hui-Su; Hwang, Dae-Sik; Lee, Jae-Seong

2017-11-30

Recently, accidental spills of heavy oil have caused adverse effects in marine organisms. Oil pollution can induce damages on development and reproduction, linking with detrimental effects on diverse molecular levels of genes and proteins in plankton and fish. However, most information was mainly focused on marine vertebrates and consequently, limited information was available in marine invertebrates. Furthermore, there is still a lack of knowledge bridging in vivo endpoints with the functional regulation of cytochrome P450 (CYP) genes in response to oil spill pollution in marine invertebrates. In this paper, adverse effects of oil spill pollution in marine invertebrates are summarized with the importance of CYP genes as a potential biomarker, applying for environmental monitoring to detect oil spill using marine copepods. Copyright © 2016 Elsevier Ltd. All rights reserved.

4-Hydroxyphenylpyruvate Dioxygenase Inhibitors: From Chemical Biology to Agrochemicals.

PubMed

Ndikuryayo, Ferdinand; Moosavi, Behrooz; Yang, Wen-Chao; Yang, Guang-Fu

2017-10-04

The development of new herbicides is receiving considerable attention to control weed biotypes resistant to current herbicides. Consequently, new enzymes are always desired as targets for herbicide discovery. 4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.27) is an enzyme engaged in photosynthetic activity and catalyzes the transformation of 4-hydroxyphenylpyruvic acid (HPPA) into homogentisic acid (HGA). HPPD inhibitors constitute a promising area of discovery and development of innovative herbicides with some advantages, including excellent crop selectivity, low application rates, and broad-spectrum weed control. HPPD inhibitors have been investigated for agrochemical interests, and some of them have already been commercialized as herbicides. In this review, we mainly focus on the chemical biology of HPPD, discovery of new potential inhibitors, and strategies for engineering transgenic crops resistant to current HPPD-inhibiting herbicides. The conclusion raises some relevant gaps for future research directions.

Monitoring and Benchmarking eHealth in the Nordic Countries.

PubMed

Nøhr, Christian; Koch, Sabine; Vimarlund, Vivian; Gilstad, Heidi; Faxvaag, Arild; Hardardottir, Gudrun Audur; Andreassen, Hege K; Kangas, Maarit; Reponen, Jarmo; Bertelsen, Pernille; Villumsen, Sidsel; Hyppönen, Hannele

2018-01-01

The Nordic eHealth Research Network, a subgroup of the Nordic Council of Ministers eHealth group, is working on developing indicators to monitor progress in availability, use and outcome of eHealth applications in the Nordic countries. This paper reports on the consecutive analysis of National eHealth policies in the Nordic countries from 2012 to 2016. Furthermore, it discusses the consequences for the development of indicators that can measure changes in the eHealth environment arising from the policies. The main change in policies is reflected in a shift towards more stakeholder involvement and intensified focus on clinical infrastructure. This change suggests developing indicators that can monitor understandability and usability of eHealth systems, and the use and utility of shared information infrastructure from the perspective of the end-users - citizens/patients and clinicians in particular.

Treatment for Substance Use Disorder: Opportunities and Challenges under the Affordable Care Act

PubMed Central

Tai, Betty; Volkow, Nora D.

2016-01-01

Addiction is a chronic brain disease with consequences that remain problematic years after discontinuation of use. Despite this, treatment models focus on acute interventions and are carved out from the main health care system. The Patient Protection and Affordable Care Act (2010) brings the opportunity to change the way substance use disorder (SUD) is treated in the United States. The treatment of SUD must adapt to a chronic care model offered in an integrated care system that screens for at-risk patients and includes services needed to prevent relapses. The partnering of the health care system with substance abuse treatment programs could dramatically expand the benefits of prevention and treatment of SUD. Expanding roles of health information technology and nonphysician workforces, such as social workers, are essential to the success of a chronic care model. PMID:23731411

The overlooked "nonclassical" functions of major histocompatibility complex (MHC) class II antigens in immune and nonimmune cells.

PubMed

Altomonte, M; Pucillo, C; Maio, M

1999-06-01

Besides their "classical" antigenic peptide-presenting activity, major histocompatibility complex (MHC) class II antigens can activate different cellular functions in immune and nonimmune cells. However, this "nonclassical" role and its functional consequences are still substantially overlooked. In this review, we will focus on these alternative functional properties of MHC class II antigens, to reawaken attention to their present and foreseeable immunobiologic and pathogenetic implications. The main issues that will be addressed concern 1) the role of MHC class II molecules as basic components of exchangeable oligomeric protein complexes with intracellular signaling ability; 2) the nonclassical functions of MHC class II antigens in immune cells; 3) the pathogenetic role of MHC class II antigens in inflammatory/autoimmune and infectious disease; and 4) the functional role of MHC class II antigens in solid malignancies.

Adolescents’ perception of substance use and factors influencing its use: a qualitative study in Abu Dhabi

PubMed Central

Al Ozaibi, Naseeba; Elarabi, Hisham; El-Kashef, Ahmed; Wanigaratne, Shamil; Almarzouqi, Amna; Alhosani, Ayesha; Al Ghaferi, Hamad

2015-01-01

Summary Objective The objective of this article is to gain a deeper understanding of the attitudes and perceptions of adolescents in the United Arab Emirates regarding substance and to identify factors that, in their view, may influence the risk of substance use and suggest possible interventions. Design This was a qualitative study that used a focus group approach. Setting The study was carried out in Abu Dhabi, United Arab Emirates. Participants Male and female teenagers aged 13-18 years residing in the emirate of Abu Dhabi. Main outcome measures Adolescents’ awareness of substance use, patterns of use and associated harm; Adolescents' perceptions about the factors associated with substance use. Results Six focus groups were carried out, and a total of 41 adolescents (20 males and 21 females) participated. Data analysis identified three main themes: (1) adolescents’ awareness of substance use and associated harm; (2) gender role and image and (3) perceived factors affecting substance use among adolescents. Knowledge of substances and related consequences of use varied between groups but was compatible with participants’ age and school years. Factors that participants believed influenced substance use were classified into: (1) parent–adolescent relationship, (2) peer pressure, (3) substance accessibility, (4) religiosity and (5) others. Many factors were believed to increase the risk of substance use among adolescents such as peer pressure, inadequate knowledge of the harmful consequences of drug use, family-related factors (e.g. low monitoring and poor parent–adolescents relationship), affordability and availability of substances, boredom and affluence. On the other hand, religiosity was as a shield against substance use, especially alcohol. Other identified protective factors included carrying out schools- and communities-based educational campaigns, enhancing social workers’ ability to raise awareness and detect early signs of addiction and implementing CCTV systems in schools. Conclusions The study was successful in exploring adolescents’ awareness of substances and associated harm to health from their use. Also, it identifies a number of risk and protective factors based on the perceptions of a group of adolescents residing in the United Arab Emirates. Such factors can guide the planning, designing and implementing of prevention programmes that focus on raising awareness about the harms of substance use. The study findings would suggest that multifactorial prevention programmes that address social norms, gender role and image, and incorporate drug policy, religion, family and school would be more effective and may have better protective outcomes. PMID:25780594

A Developmental Study of School Theft.

ERIC Educational Resources Information Center

Dodson, Peter K.; Evans, Ellis D.

1985-01-01

Students (N=200) in grades 4 through 8 and 10 completed questionnaire measuring perceptions of school theft incidence and seriousness, personal responsibility for correcting theft, causal attributions of theft, and perceived consequences of thievery. Main grade effect was observed for personal responsibility and consequences, but represented…

The Consequences of Nuclear Terrorism,

DTIC Science & Technology

1979-08-01

attention from focusing for a length of time on a single nuclear incident would also have an effect . 7v . 19 III. THE CONSEQUENCES * We presume now in our...AD-AI61 788 THE CONSEQUENCES OF NUCLEAR TERRORISMC) RND CORP 1/1 SANTA MONICA CA 8 M JENKCINS AUG 79 RAVD/P-6373p UNCLASSIFIED F/G 15/7 M - Kill...111 *-*------1*- .29 .;-.R ~in 1111111U :NA2,NAL tiuRLAUOf STANDARDS !Q61 A I 11111 7l 4’ THE CONSEQUENCES OF NUCLEAR TERRORISM Brian Michael Jenkins

Student Perception of Teachers' Pets and Class Victims.

ERIC Educational Resources Information Center

Martin, Wilfred B.

1984-01-01

Uses the concepts of "identity" and "situational identity," to focus on student-perceived consequences of teachers' pet and class victim phenomena in the high school setting. Analyzes five classes of consequences: being left out, the marking process, the disciplinary process, disliking teachers, and antipathy and empathy among…

A Meta-Analysis of the Regulatory Focus Nomological Network: Work-Related Antecedents and Consequences

ERIC Educational Resources Information Center

Gorman, C. Allen; Meriac, John P.; Overstreet, Benjamin L.; Apodaca, Steven; McIntyre, Ashley L.; Park, Paul; Godbey, Jennifer N.

2012-01-01

Regulatory focus theory (Higgins, 1997, 1998) has received a great deal of recent attention in the organizational behavior literature. Despite the amount of new evidence surrounding regulatory focus and its relationships with other variables, a quantitative summary of this literature is lacking. The authors used meta-analysis to summarize…

Responsive and Proactive Stakeholder Orientation in Public Universities: Antecedents and Consequences

ERIC Educational Resources Information Center

Alarcón-del-Amo, María-del-Carmen; Casablancas-Segura, Carme; Llonch, Joan

2016-01-01

This study, based on institutional theory, dynamic capabilities, and stakeholder theory, investigates the relationships between the antecedents of responsive and proactive stakeholder orientation and their consequences in the public university context. The results obtained mainly stress that the mimetic effect of copying successful university…

How the causes, consequences and solutions for problem gambling are reported in Australian newspapers: a qualitative content analysis.

PubMed

Miller, Helen E; Thomas, Samantha L; Robinson, Priscilla; Daube, Mike

2014-12-01

To inform public health approaches to problem gambling by examining how the news media covers problem gambling, with a particular focus on the causes, consequences and solutions to problem gambling, and the 'actors' and sources who influence media coverage. A qualitative content analysis guided by framing theory analysed coverage of problem gambling in Australian newspapers in the period 1 July 2011 to 30 June 2012. Solutions to problem gambling were more frequently discussed than causes and consequences. A focus on the responsibility of individuals was preferred to reporting that focused on broader social, ecological, and industry determinants of problem gambling. Reporting was highly politicised, with politicians frequently quoted and political issues frequently discussed. In contrast, the community sector, health professionals and problem gamblers were rarely quoted. This analysis has revealed the need for a more proactive, coordinated approach to the media by both public health researchers and health groups. The establishment of a gambling-specific coalition to push for evidence-based reform is recommended. © 2014 Public Health Association of Australia.

The Current State of Personal Training: an Industry Perspective of Personal Trainers in a Small Southeast Community

PubMed Central

Melton, Deana I.; Katula, Jeffrey A.; Mustian, Karen M.

2014-01-01

Although research has identified a number of qualities and competencies necessary to be an effective exercise leader, the fitness industry itself is largely unregulated and lacks a unified governing body. As such, a plethora of personal trainer certifications exists with varying degrees of validity that fail to ensure qualified trainers and, therefore, protect the consumer. It is argued that the potential consequences of this lack of regulation are poor societal exercise adherence, potential injury to the client, and poor public perception of personal trainers. Additionally, it is not known whether personal trainers are meeting the needs of their clients or what criteria are used in the hiring of personal trainers. Thus, the purpose of this investigation was to examine the current state of personal training in a midsized Southeast city by using focus group methodology. Local personal trainers were recruited for the focus groups (n = 11), and the results from which were transcribed, coded, and analyzed for themes using inductive reasoning by the authors. Qualities and characteristics that identified by participants clustered around 4 main themes. Client selection rationale consisted of qualities that influenced a client’s decision to hire a particular trainer (e.g., physique, gender, race). Client loyalty referred to the particular qualities involved in maintaining clients (e.g., motivation skills, empathy, social skills). Credentials referred to formal training (e.g., college education, certifications). Negative characteristics referred to qualities considered unethical or unprofessional (e.g., sexual comments, misuse of power) as well as the consequences of those behaviors (e.g., loss of clients, potential for litigation). These results are discussed regarding the implications concerning college programs, certification organizations, increasing public awareness of expectations of qualified trainers, and a move towards state licensure. PMID:18438226

The current state of personal training: an industry perspective of personal trainers in a small Southeast community.

PubMed

Melton, Deana I; Katula, Jeffrey A; Mustian, Karen M

2008-05-01

Although research has identified a number of qualities and competencies necessary to be an effective exercise leader, the fitness industry itself is largely unregulated and lacks a unified governing body. As such, a plethora of personal trainer certifications exists with varying degrees of validity that fail to ensure qualified trainers and, therefore, protect the consumer. It is argued that the potential consequences of this lack of regulation are poor societal exercise adherence, potential injury to the client, and poor public perception of personal trainers. Additionally, it is not known whether personal trainers are meeting the needs of their clients or what criteria are used in the hiring of personal trainers. Thus, the purpose of this investigation was to examine the current state of personal training in a midsized Southeast city by using focus group methodology. Local personal trainers were recruited for the focus groups (n = 11), and the results from which were transcribed, coded, and analyzed for themes using inductive reasoning by the authors. Qualities and characteristics that identified by participants clustered around 4 main themes. Client selection rationale consisted of qualities that influenced a client's decision to hire a particular trainer (e.g., physique, gender, race). Client loyalty referred to the particular qualities involved in maintaining clients (e.g., motivation skills, empathy, social skills). Credentials referred to formal training (e.g., college education, certifications). Negative characteristics referred to qualities considered unethical or unprofessional (e.g., sexual comments, misuse of power) as well as the consequences of those behaviors (e.g., loss of clients, potential for litigation). These results are discussed regarding the implications concerning college programs, certification organizations, increasing public awareness of expectations of qualified trainers, and a move towards state licensure.

Consequences of Growing Up Poor.

ERIC Educational Resources Information Center

Duncan, Greg J., Ed.; Brooks-Gunn, Jeanne, Ed.

The consequences and correlates of growing up poor as well as the mechanisms through which poverty influences children are explored. This book is organized with a primary focus on research findings and a secondary concern with policy implications. The chapters are: (1) "Poor Families, Poor Outcomes: The Well-Being of Children and Youth" (Jeanne…

Retrenchment Policies and Their Organizational Consequences.

ERIC Educational Resources Information Center

Berger, Michael A.

This paper focuses on the organizational consequences of retrenchment policies emphasizing efficiency (selective cuts to insure long-term survival) and equity (across the board actions). The effectiveness of each of these policies was tested on 59 cases of school district enrollment decline over a 10-year period by means of a…

Enhancing Learning and Retarding Forgetting: Choices and Consequences

ERIC Educational Resources Information Center

Pashler, Harold; Rohrer, Doug; Cepeda, Nicholas J.; Carpenter, Shana K.

2007-01-01

Our research on learning enhancement has been focusing on the consequences for learning and forgetting of some of the more obvious and concrete choices that arise in instruction, including: How does spacing of practice affect retention of information over significant retention intervals (up to two years)? Do spacing effects generalize beyond…

The Intended and Unintended Consequences of International Service-Learning

ERIC Educational Resources Information Center

Crabtree, Robbin D.

2013-01-01

Previous research on service-learning in international contexts tends to focus on the benefits and outcomes for students and educational institutions. This essay is intended to provoke further examination of issues related to university-community engagement in global contexts, particularly in terms of the consequences for host communities. In…

78 FR 68691 - Airworthiness Directives; Fokker Services B.V. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-15

... the main fuel tank vapor space, which could result in a fuel tank explosion and consequent loss of the..., Aerospace Engineer, International Branch, ANM-116, Transport Airplane Directorate, FAA, 1601 Lind Avenue SW... fuel tank vapour space, possibly resulting in a fuel tank explosion and consequent loss of the...

Filtering beyond CIPA: Consequences of and Alternatives to Overfiltering in Schools

ERIC Educational Resources Information Center

Batch, Kristen R.; Magi, Trina; Luhtala, Michelle

2015-01-01

The article is divided into three sections. The main section, "Filtering beyond CIPA: Consequences of and Alternatives to Overfiltering in Schools" (Kristen Batch) describes factors that contribute to the overimplementation of CIPA. Internet filtering is a routine practice in public schools and libraries. The Children's Internet…

Craniopharyngioma and hypothalamic injury: latest insights into consequent eating disorders and obesity

PubMed Central

Müller, Hermann L.

2016-01-01

Purpose of review Hypothalamic alterations, pathological or treatment induced, have major impact on prognosis in craniopharyngioma patients mainly because of consequent hypothalamic obesity. Recent insight in molecular genetics, treatment strategies, risk factors and outcomes associated with hypothalamic obesity provide novel therapeutic perspectives. This review includes relevant publications since 2013. Recent findings Recent findings confirm that alterations in posterior hypothalamic areas because of tumour location and/or treatment-related injuries are associated with severe hypothalamic obesity, reduced overall survival and impaired quality of life in long-term survivors of childhood-onset craniopharyngioma. However, eating disorders are observed because of hypothalamic obesity without clear disease-specific patterns. Treatment options for hypothalamic obesity are very limited. Treatment with invasive, nonreversible bariatric methods such as Roux-en-Y gastric bypass is most efficient in weight reduction, but controversial in the paediatric population because of medical, ethical, and legal considerations. Accordingly, treatment in craniopharyngioma should focus on prevention of (further) hypothalamic injury. Presurgical imaging for grading of hypothalamic involvement should be the basis for hypothalamus-sparing strategies conducted by experienced multidisciplinary teams. Summary Until a nonsurgical therapeutic option for hypothalamic obesity for paediatric patients is found, prevention of hypothalamic injury should be the preferred treatment strategy, conducted exclusively by experienced multidisciplinary teams. PMID:26574645

Experimental und numerical investigations on cooling efficiency of Air-Mist nozzles on steel during continuous casting

NASA Astrophysics Data System (ADS)

Arth, G.; Taferner, M.; Bernhard, C.; Michelic, S.

2016-07-01

Cooling strategies in continuous casting of steel can vary from rapid cooling to slow cooling, mainly controlled by adjusting the amount of water sprayed onto the surface of the product. Inadequate adjustment however can lead to local surface undercooling or reheating, leading to surface and inner defects. This paper focuses on cooling efficiency of Air-Mist nozzles on casted steel and the experimental and numerical prediction of surface temperature distributions over the product width. The first part explains the determination of heat transfer coefficients (HTC) on laboratory scale, using a so called nozzle measuring stand (NMS). Based on measured water distributions and determined HTC's for air-mist nozzles using the NMS, surface temperatures are calculated by a transient 2D-model on a simple steel plate, explained in the second part of this paper. Simulations are carried out varying water impact density and spray water distribution, consequently influencing the local HTC distribution over the plate width. Furthermore, these results will be interpreted with regard to their consequence for surface and internal quality of the cast product. The results reveal the difficulty of correct adjustment of the amount of sprayed water, concurrent influencing water distribution and thus changing HTC distribution and surface temperature.

[Violence on health care workers].

PubMed

Cannavò, M; Fusaro, N; Colaiuda, F; Rescigno, G; Fioravanti, M

2017-01-01

The Emergency Department (ED) is vulnerable for workplace violence, but little is known about this and its consequences. Objectives of this study were presence, characteristics and effects of violence from patients and visitors on health care workers in an Emergency Department (ED). This study was about the Accident and Emergency Department, S. Pertini Hospital, (ASL RMB, Rome, Italy). Data were collected from November 2014 to January 2015 on frequency and type of violent behavior in the past five years experienced by staff members and their level of stress by an ad hoc questionnaire for the evaluation of violent events in health activities (QVS) and a questionnaire on perceived work-related stress (QES). Of the 58 eligible workers, 51 completed the interview. Health care workers were regularly exposed to violence with a consequent severe underreporting to work authorities and only a minor reporting to the police. A diffuse belief that workplace violence is a normal part of the work was also identified. Aggressors were usually patients or their relatives and were mainly males. Health care workers may suffer physical and emotional harm. Emergency Department health care workers are at risk of experiencing workplace violence and should have specific training and support in the management of violent situations focused on early identification, communication strategies, and de-escalation techniques.

Antecedents and near-term consequences for interdisciplinary dissertators.

PubMed

Kniffin, Kevin M; Hanks, Andrew S

2017-01-01

Given the complexity of questions studied by academicians, institutions are increasingly encouraging interdisciplinary research to tackle these problems; however, neither the individual-level pathways leading to the pursuit of interdisciplinary research nor the resulting market outcomes have been closely examined. In this study, we focus attention on the individuals who complete interdisciplinary dissertations to ask "who are they and how do they fare after earning the PhD?" Since interdisciplinary research is known to be relatively risky among academics, we examine demographic variables that are known to be associated in other contexts with risk-taking before considering whether interdisciplinarians' outcomes are different upon graduating. First among our three main findings, students whose fathers earned a college degree demonstrated a 1.3% higher probability of pursuing interdisciplinary research. Second, the probability that non-citizens pursue interdisciplinary dissertation work is 4.6% higher when compared with US citizens. Third, individuals who complete an interdisciplinary dissertation tend to earn approximately 2% less in the year after graduation; however, mediation analyses show that the decision to become a postdoctoral researcher accounts for the apparent salary penalty. Our findings shed light on the antecedents and near-term consequences for individuals who complete interdisciplinary dissertations and contribute to broader policy debates concerning supports for academic career paths.

Decision Making under Ambiguity and Objective Risk in Higher Age - A Review on Cognitive and Emotional Contributions.

PubMed

Liebherr, Magnus; Schiebener, Johannes; Averbeck, Heike; Brand, Matthias

2017-01-01

The ability of decision making plays a highly relevant role in our survival, but is adversely affected during the process of aging. The present review aims to provide a better understanding of age-related differences in decision making and the role of cognitive and emotional factors in this context. We reviewed the literature about age-effects on decision-making performance, focusing on decision making under ambiguous and objective risk. In decisions under ambiguous risks, as measured by the Iowa Gambling Task, decisions are based on the experiences with consequences. In this case, many articles have attributed age-related impairments in decision making to changes in emotional and somatic reward- and punishment processing. In decisions under objective risks, as measured for example by the Game of Dice Task, decisions can be based on explicit information about risks and consequences. In this case, age-related changes have been attributed mainly to a cognitive decline, particularly impaired executive functions. However, recent findings challenge these conclusions. The present review summarizes neuropsychological and neurophysiological findings of age-related differences in decision making under ambiguous and objective risk. In this context, the relevance of learning, but also of cognitive and emotional contributors - responsible for age-related differences in decision making - are additionally pointed out.

Decision Making under Ambiguity and Objective Risk in Higher Age – A Review on Cognitive and Emotional Contributions

PubMed Central

Liebherr, Magnus; Schiebener, Johannes; Averbeck, Heike; Brand, Matthias

2017-01-01

The ability of decision making plays a highly relevant role in our survival, but is adversely affected during the process of aging. The present review aims to provide a better understanding of age-related differences in decision making and the role of cognitive and emotional factors in this context. We reviewed the literature about age-effects on decision-making performance, focusing on decision making under ambiguous and objective risk. In decisions under ambiguous risks, as measured by the Iowa Gambling Task, decisions are based on the experiences with consequences. In this case, many articles have attributed age-related impairments in decision making to changes in emotional and somatic reward- and punishment processing. In decisions under objective risks, as measured for example by the Game of Dice Task, decisions can be based on explicit information about risks and consequences. In this case, age-related changes have been attributed mainly to a cognitive decline, particularly impaired executive functions. However, recent findings challenge these conclusions. The present review summarizes neuropsychological and neurophysiological findings of age-related differences in decision making under ambiguous and objective risk. In this context, the relevance of learning, but also of cognitive and emotional contributors – responsible for age-related differences in decision making – are additionally pointed out. PMID:29270145

Implications of domestic food practices for the presence of bioactive components in meats with special reference to meat-based functional foods.

PubMed

Jiménez-Colmenero, Francisco; Cofrades, Susana; Herrero, Ana M; Ruiz-Capillas, Claudia

2017-06-14

Although an essential component of the diet, the consumption of meat is in question. Meat is a major source of beneficial compounds but it also contains other substances with negative health implications. Functional foods, which are leading trends in the food industry, constitute an excellent opportunity for the meat sector to improve healthier meat options. Most studies on meat-based functional foods have focused mainly on the application of different strategies (animal production practices and meat transformation systems) to improve (increase/reduce) the presence of bioactive (healthy/unhealthy) compounds; these have led to the development of numerous products, many of them by the meat industry. However, like other foods, after purchase meats undergo certain processes before they are consumed, and these affect their composition. Although domestic handling practices can significantly alter the make-up of the marketed product in terms of healthy/unhealthy compounds, there are very few studies on their consequences. This paper provides an overview of the influence of different domestic practices (from shopping to eating) habitually followed by consumers on the presence of, and consequently on the levels of exposure to, (healthy and unhealthy) food components associated with the consumption of meats, with special reference to meat-based functional foods.

"Not a replacement": emotional experiences and practical consequences of Israeli second couplehood stepfamilies constructed in old age.

PubMed

Koren, Chaya; Lipman-Schiby, Sharon

2014-12-01

The increase in life expectancy enhances phenomena such as second couplehood in old age following widowhood or divorce as an alternative way of coping with changes that occur with aging. Research on the phenomenon has focused mainly on individual and dyadic perspectives of the repartnered. The aim of this article was to explore repartnering from the stepfamily's perspective, which has scarcely been studied. Nineteen Israeli stepfamilies (38 multigenerational families) were recruited using criterion sampling, of men who repartnered at age 65+ and women at 60+, with children and grandchildren from a lifelong marriage that ended in widowhood or divorce. We audio-recorded and transcribed verbatim 107 semi-structured, qualitative interviews with older partners, their adult children, and grandchildren. Analysis was based on grounded theory and dyadic analysis principles adapted to families. It showed how repartnering in old age changed the family structure, constructing complex stepfamilies, which require further study. Emotional experiences refer to repartnering being a replacement for couplehood but not for parenthood/grandparenthood. Practical consequences refer to "knowing their place" within the stepfamily and included the following subthemes: showing affection; participating in memorials for the deceased spouse; sharing, listening, and assisting. Findings are discussed regarding life course and family life cycle perspectives. Copyright © 2014 Elsevier Inc. All rights reserved.

Identification of trends in scientific publications related to genetic polymorphisms in gestational diabetes mellitus.

PubMed

Gomes, J S; Minasi, L B; da Cruz, A D; Rodrigues, F M

2016-05-09

Gestational diabetes is a genetic multifactorial systemic disease that has been extensively studied. Consequently, there is a large volume of scientific literature pertaining to genes associated with gestational diabetes. The aim of this study was to characterize the main trends in scientific publications focusing on the associations between genetic polymorphisms and gestational diabetes mellitus (GDM). The related articles were extracted from Scopus using the key words "genetic polymorphism" and "gestational diabetes mellitus"; the collected data focused on various fields (medical, biochemical, etc.) and included papers published within December 2013. One hundred and eighty-three relevant articles published between 1987 and 2013 were identified; we observed a significantly increasing trend in the number of publications pertaining to GDM. A majority of the articles focused on the medical (59.9%), biochemical, and genetics and molecular biological (29.6%) aspects of the disease. The genes coding for transcription factor 7-like 2 and glucokinase (TCF7L2, 29% and GCK, 28%) were predominantly studied and reported. This study helped quantify the growth in research pertaining to GDM; researchers from the USA have published a majority of the publications related to GDM. Several candidate genes have been linked to diabetes; however, the specific gene locus responsible for GDM has not yet been identified. The results of this study could help determine the orientation of future research on genetic factors associated with GDM.

Experiences of participating in return-to-work group programmes for people with musculoskeletal disorders: A focus group study.

PubMed

Hamnes, Bente; Rønningen, Aud; Skarbø, Åse

2017-09-01

The present study aimed to explore the experiences of individuals with musculoskeletal disorders (MSDs) who had participated in return-to-work group programmes (RTW-GPs) and to assess whether the programmes had had an impact on their work disability. Three focus group interviews and one individual interview were conducted involving 17 women (mean age = 47) with MSDs who had completed RTW-GPs. All interviews were audio-recorded, transcribed verbatim and analysed using thematic analyses. Participant experiences were categorised into three main themes: changed way of thinking, the importance of being able to work, and a changed lifestyle. The respondents said that participation in the RTW-GPs had enabled them to shift their focus from problems to opportunities. They had become more aware of strategies to enhance their energy levels and continue working. Several participants had reduced their work hours to achieve a better balance between work and daily life. Many participants had also changed their lifestyle habits, which had led to weight reduction, more energy and less pain. The study participants had attained a heightened awareness of what they could do to continue working. Many participants had introduced changes in their daily lives, with consequences for employment, social life and lifestyle. The findings suggest that RTW-GPs can help people with MSDs to remain in employment and prevent absenteeism. Copyright © 2017 John Wiley & Sons, Ltd.

Cesarean section in the People’s Republic of China: current perspectives

PubMed Central

Feng, Xing Lin; Wang, Ying; An, Lin; Ronsmans, Carine

2014-01-01

Objective To review the current knowledge on the prevalence, reasons, and consequences of cesarean sections in the People’s Republic of China. Methods Peer-reviewed articles were systematically searched on PubMed. The following Chinese databases were comprehensively searched: the China National Knowledge Infrastructure, Wanfang, and the VIP information. The databases were searched from inception to September 1, 2013. Two reviewers independently screened the titles and abstracts for eligibility. Full texts of eligible papers were reviewed, where relevant references were hand-searched and reviewed. Findings Sixty articles were included from PubMed, 17 articles were intentionally picked out from Chinese journals, and five additional articles were added, for a total of 82 articles for the analysis. With a current national rate near 40%, the literature consistently reported a rapid rise of cesarean sections in the People’s Republic of China in the past decades, irrespective of where people lived or their socioeconomic standing. Nonclinical factors were considered as the main drivers fueling the rise of cesareans in the People’s Republic of China. There was a lively debate on whether women’s preferences or providers’ distorted financial incentives affected the rise in cesarean sections. However, recent evidence suggests that it might be the People’s Republic of China’s health development approach – focusing on specialized care and marginalizing primary care – that is playing a role. Although 30 articles were identified studying the consequences of cesareans, the methodologies are in general weak and the themes are out of focus. Conclusion The overuse of cesareans is rising alarmingly in the People’s Republic of China and has become a real public health problem. No consensus has been made on the leverage factors that drive the cesarean epidemic, particularly for those nonclinical factors. The more macro level structural factors may have played a part, though further research is warranted to understand the mechanisms. Knowledge of the consequences of cesareans, particularly for women, is limited in the People’s Republic of China, leaving a substantial literature gap. PMID:24470775

Conventional Systems of Classroom Discipline (the Patriarchy Speaks).

ERIC Educational Resources Information Center

Blumenfeld-Jones, Donald S.

1996-01-01

Considers traditional classroom discipline systems as patriarchal moral systems focused on hyperindividuality and dependent upon rules, consequences, and principles focused through authoritarian structures. Critiques the Assertive Discipline, Control Theory, and Discipline with Dignity discipline systems, and proposes an alternative model for…

School Refusal Behavior: Classification, Assessment, and Treatment Issues.

ERIC Educational Resources Information Center

Lee, Marcella I.; Miltenberger, Raymond G.

1996-01-01

Discusses diagnostic and functional classification, assessment, and treatment approaches for school refusal behavior. Diagnostic classification focuses on separation anxiety disorder, specific phobia, social phobia, depression, and truancy. Functional classification focuses on the maintaining consequences of the behavior, such as avoidance of…

Association between illness perceptions and return-to-work expectations in workers with common mental health symptoms.

PubMed

Løvvik, Camilla; Øverland, Simon; Hysing, Mari; Broadbent, Elizabeth; Reme, Silje E

2014-03-01

Mental health symptoms (MHSs) may affect people's work capacity and lead to sickness absence and disability. Expectations and perceptions of illness have been shown to influence return to work (RTW) across health conditions, but we know little about illness perceptions and RTW-expectations in MHSs. The aim of this study was to investigate the association between illness perceptions and RTW-expectations in a group struggling with work participation due to MHSs. Cross-sectional associations between illness perceptions and return to work expectations at baseline were analyzed for 1,193 participants who reported that MHSs affected their work participation. The study was part of a randomized controlled trial evaluating the effect of job focused Cognitive Behavioral Therapy (CBT) combined with supported employment (IPS). Participants were from a working age population with diverse job status. There was a strong and salient relationship between illness perceptions and RTW-expectations. When adjusting for demographic and clinical variables, the components consequences, personal control, identity and illness concern remained significantly associated with uncertain and negative RTW-expectations. Less illness understanding remained significantly associated with uncertain RTW-expectations, while timeline and emotional representations remained significantly associated with negative RTW-expectations. In the fully adjusted model only the consequences component (believing that illness has more severe consequences) remained significantly associated with RTW-expectations. Openly asked, participants reported work, personal relationships and stress as main causes of their illness. In people with MHSs who struggle with work participation, perceptions and beliefs about their problems are strongly associated with their expectations to return to work.

Host shifts and molecular evolution of H7 avian influenza virus hemagglutinin

PubMed Central

2011-01-01

Evolutionary consequences of host shifts represent a challenge to identify the mechanisms involved in the emergence of influenza A (IA) viruses. In this study we focused on the evolutionary history of H7 IA virus in wild and domestic birds, with a particular emphasis on host shifts consequences on the molecular evolution of the hemagglutinin (HA) gene. Based on a dataset of 414 HA nucleotide sequences, we performed an extensive phylogeographic analysis in order to identify the overall genetic structure of H7 IA viruses. We then identified host shift events and investigated viral population dynamics in wild and domestic birds, independently. Finally, we estimated changes in nucleotide substitution rates and tested for positive selection in the HA gene. A strong association between the geographic origin and the genetic structure was observed, with four main clades including viruses isolated in North America, South America, Australia and Eurasia-Africa. We identified ten potential events of virus introduction from wild to domestic birds, but little evidence for spillover of viruses from poultry to wild waterbirds. Several sites involved in host specificity (addition of a glycosylation site in the receptor binding domain) and virulence (insertion of amino acids in the cleavage site) were found to be positively selected in HA nucleotide sequences, in genetically unrelated lineages, suggesting parallel evolution for the HA gene of IA viruses in domestic birds. These results highlight that evolutionary consequences of bird host shifts would need to be further studied to understand the ecological and molecular mechanisms involved in the emergence of domestic bird-adapted viruses. PMID:21711553

Perioperative Care for Pediatric Patients With Penetrating Brain Injury: A Review.

PubMed

Mikhael, Marco; Frost, Elizabeth; Cristancho, Maria

2017-05-19

Traumatic brain injury (TBI) continues to be the leading cause of death and acquired disability in young children and adolescents, due to blunt or penetrating trauma, the latter being less common but more lethal. Penetrating brain injury (PBI) has not been studied extensively, mainly reported as case reports or case series, due to the assumption that both types of brain injury have common pathophysiology and consequently common management. However, recommendations and guidelines for the management of PBI differ from those of blunt TBI in regards to neuroimaging, intracranial pressure (ICP) monitoring, and surgical management including those pertaining to vascular injury. PBI was one of the exclusion criteria in the second edition of guidelines for the acute medical management of severe TBI in infants, children, and adolescents that was published in 2012 (it is referred to as "pediatric guidelines" in this review). Many reviews of TBI do not differentiate between the mechanisms of injury. We present an overview of PBI, its presenting features, epidemiology, and causes as well as an analysis of case series and the conclusions that may be drawn from those and other studies. More clinical trials specific to penetrating head injuries in children, focusing mainly on pathophysiology and management, are needed. The term PBI is specific to penetrating injury only, whereas TBI, a more inclusive term, describes mainly, but not only, blunt injury.

Bouncing forward of young refugees: a perspective on resilience research directions

PubMed Central

Sleijpen, Marieke; June ter Heide, F. Jackie; Mooren, Trudy; Boeije, Hennie R.; Kleber, Rolf J.

2013-01-01

While studies on the consequences of trauma and forced migration on young refugees have focused mainly on their pathology, a focus on resilience in young refugees is needed to adequately represent their response to adversity and to help understand their needs. The aim of this article is to present a proposed study of resilience in young refugees which has been informed by an overview of achievements and challenges in the field of resilience. In order to advance the field of resilience, several topics need clarification: definition and assessment of resilience, the relation of resilience to other constructs and the underlying biological and external factors influencing resilience. With respect to young refugees, the cross-cultural applicability of resilience has to be examined. Qualitative research, mixed method designs, comparative studies, and longitudinal studies seem especially promising in furthering this goal. The proposed study compares refugee adolescents with Dutch adolescents. Data from qualitative evidence synthesis, interviews, questionnaires, experiments, and DNA analysis will be combined to provide a multifaceted picture of factors contributing to resilience, resulting in a better understanding and efficient use of “resilience” to meet the needs of traumatised youth. PMID:23671759

Interaction and common ground in dementia: Communication across linguistic and cultural diversity in a residential dementia care setting.

PubMed

Strandroos, Lisa; Antelius, Eleonor

2017-09-01

Previous research concerning bilingual people with a dementia disease has mainly focused on the importance of sharing a spoken language with caregivers. While acknowledging this, this article addresses the multidimensional character of communication and interaction. As using spoken language is made difficult as a consequence of the dementia disease, this multidimensionality becomes particularly important. The article is based on a qualitative analysis of ethnographic fieldwork at a dementia care facility. It presents ethnographic examples of different communicative forms, with particular focus on bilingual interactions. Interaction is understood as a collective and collaborative activity. The text finds that a shared spoken language is advantageous, but is not the only source of, nor a guarantee for, creating common ground and understanding. Communicative resources other than spoken language are for example body language, embodiment, artefacts and time. Furthermore, forms of communication are not static but develop, change and are created over time. Ability to communicate is thus not something that one has or has not, but is situationally and collaboratively created. To facilitate this, time and familiarity are central resources, and the results indicate the importance of continuity in interpersonal relations.

Advances in pollination ecology from tropical plantation crops.

PubMed

Klein, Alexandra-Maria; Cunningham, Saul A; Bos, Merijn; Steffan-Dewenter, Ingolf

2008-04-01

Although ecologists traditionally focus on natural ecosystems, there is growing awareness that mixed landscapes of managed and unmanaged systems provide a research environment for understanding basic ecological relationships on a large scale. Here, we show how tropical agroforestry systems can be used to develop ideas about the mechanisms that influence species diversity and subsequent biotic interactions at different spatial scales. Our focus is on tropical plantation crops, mainly coffee and cacao, and their pollinators, which are of basic ecological interest as partners in an important mutualistic interaction. We review how insect-mediated pollination services depend on local agroforest and natural habitats in surrounding landscapes. Further, we evaluate the functional significance of pollinator diversity and the explanatory value of species traits, and we provide an intercontinental comparison of pollinator assemblages. We found that optimal pollination success might be best understood as a consequence of niche complementarities among pollinators in landscapes harboring various species. We further show that small cavity-nesting bees and small generalist beetles were especially affected by isolation from forest and that larger-bodied insects in the same landscapes were not similarly affected. We suggest that mixed tropical landscapes with agroforestry systems have great potential for future research on the interactions between plants and pollinators.

Recent advances on the functional and evolutionary morphology of the amniote respiratory apparatus.

PubMed

Lambertz, Markus

2016-02-01

Increased organismic complexity in metazoans was achieved via the specialization of certain parts of the body involved in different faculties (structure-function complexes). One of the most basic metabolic demands of animals in general is a sufficient supply of all tissues with oxygen. Specialized structures for gas exchange (and transport) consequently evolved many times and in great variety among bilaterians. This review focuses on some of the latest advancements that morphological research has added to our understanding of how the respiratory apparatus of the primarily terrestrial vertebrates (amniotes) works and how it evolved. Two main components of the respiratory apparatus, the lungs as the "exchanger" and the ventilatory apparatus as the "active pump," are the focus of this paper. Specific questions related to the exchanger concern the structure of the lungs of the first amniotes and the efficiency of structurally simple snake lungs in health and disease, as well as secondary functions of the lungs in heat exchange during the evolution of sauropod dinosaurs. With regard to the active pump, I discuss how the unique ventilatory mechanism of turtles evolved and how understanding the avian ventilatory strategy affects animal welfare issues in the poultry industry. © 2016 New York Academy of Sciences.

Signatures of selection acting on the innate immunity gene Toll-like receptor 2 (TLR2) during the evolutionary history of rodents.

PubMed

Tschirren, B; Råberg, L; Westerdahl, H

2011-06-01

Patterns of selection acting on immune defence genes have recently been the focus of considerable interest. Yet, when it comes to vertebrates, studies have mainly focused on the acquired branch of the immune system. Consequently, the direction and strength of selection acting on genes of the vertebrate innate immune defence remain poorly understood. Here, we present a molecular analysis of selection on an important receptor of the innate immune system of vertebrates, the Toll-like receptor 2 (TLR2), across 17 rodent species. Although purifying selection was the prevalent evolutionary force acting on most parts of the rodent TLR2, we found that codons in close proximity to pathogen-binding and TLR2-TLR1 heterodimerization sites have been subject to positive selection. This indicates that parasite-mediated selection is not restricted to acquired immune system genes like the major histocompatibility complex, but also affects innate defence genes. To obtain a comprehensive understanding of evolutionary processes in host-parasite systems, both innate and acquired immunity thus need to be considered. © 2011 The Authors. Journal of Evolutionary Biology © 2011 European Society For Evolutionary Biology.

Stigmatization and denormalization as public health policies: some Kantian thoughts.

PubMed

Dean, Richard

2014-10-01

The stigmatization of some groups of people, whether for some characteristic they possess or some behavior they engage in, will initially strike most of us as wrong. For many years, academic work in public health, which focused mainly on the stigmatization of HIV-positive individuals, reinforced this natural reaction to stigmatization, by pointing out the negative health effects of stigmatization. But more recently, the apparent success of anti-smoking campaigns which employ stigmatization of smokers has raised questions about whether stigmatization may sometimes be justified, because of its positive effects on public health. Discussion of the issue so far has focused on consequences, and on some Kantian considerations regarding the status of the stigmatized. In this article, I argue that further Kantian considerations regarding the treatment of the general public (the potential stigmatizers) also count against any public health policy involving stigmatization. Attempts to encourage stigmatization are likely to fail to appeal to the rational decision-making abilities of the general public, and the creation of stigmatized groups (even if they are stigmatized for their voluntary behavior) is an obstacle to the self-improvement of members of the general public. © 2013 John Wiley & Sons Ltd.

Contribution of plastic waste recovery to greenhouse gas (GHG) savings in Spain.

PubMed

Sevigné-Itoiz, Eva; Gasol, Carles M; Rieradevall, Joan; Gabarrell, Xavier

2015-12-01

This paper concentrates on the quantification of greenhouse gas (GHG) emissions of post-consumer plastic waste recovery (material or energy) by considering the influence of the plastic waste quality (high or low), the recycled plastic applications (virgin plastic substitution or non-plastic substitution) and the markets of recovered plastic (regional or global). The aim is to quantify the environmental consequences of different alternatives in order to evaluate opportunities and limitations to select the best and most feasible plastic waste recovery option to decrease the GHG emissions. The methodologies of material flow analysis (MFA) for a time period of thirteen years and consequential life cycle assessment (CLCA) have been integrated. The study focuses on Spain as a representative country for Europe. The results show that to improve resource efficiency and avoid more GHG emissions, the options for plastic waste management are dependent on the quality of the recovered plastic. The results also show that there is an increasing trend of exporting plastic waste for recycling, mainly to China, that reduces the GHG benefits from recycling, suggesting that a new focus should be introduced to take into account the split between local recycling and exporting. Copyright © 2015 Elsevier Ltd. All rights reserved.

Supersonics Project - Airport Noise Tech Challenge

NASA Technical Reports Server (NTRS)

Bridges, James

2010-01-01

The Airport Noise Tech Challenge research effort under the Supersonics Project is reviewed. While the goal of "Improved supersonic jet noise models validated on innovative nozzle concepts" remains the same, the success of the research effort has caused the thrust of the research to be modified going forward in time. The main activities from FY06-10 focused on development and validation of jet noise prediction codes. This required innovative diagnostic techniques to be developed and deployed, extensive jet noise and flow databases to be created, and computational tools to be developed and validated. Furthermore, in FY09-10 systems studies commissioned by the Supersonics Project showed that viable supersonic aircraft were within reach using variable cycle engine architectures if exhaust nozzle technology could provide 3-5dB of suppression. The Project then began to focus on integrating the technologies being developed in its Tech Challenge areas to bring about successful system designs. Consequently, the Airport Noise Tech Challenge area has shifted efforts from developing jet noise prediction codes to using them to develop low-noise nozzle concepts for integration into supersonic aircraft. The new plan of research is briefly presented by technology and timelines.

Role of vitamin D deficiency in systemic lupus erythematosus incidence and aggravation.

PubMed

Hassanalilou, Tohid; Khalili, Leila; Ghavamzadeh, Saeid; Shokri, Ali; Payahoo, Laleh; Bishak, Yaser Khaje

2017-12-26

Vitamin D is one of the main groups of sterols; playing an important role in phospho-calcic metabolism. The conversion of 7-dehydrocholesterol to pre- vitamin D3 in the skin, through solar ultraviolet B radiation, is the main source of vitamin D. Since lupus patients are usually photosensitive, the risk of developing vitamin D deficiency in is high in this population. Although evidences showed the connotation between systemic lupus erythematosus (SLE) and vitamin D through which SLE can lead to lower vitamin D levels, it is also important to consider the possibility that vitamin D deficiency may have a causative role in SLE etiology. This paper analyzes existing data from various studies to highlight the role of vitamin D deficiency in SLE occurrence and aggravation and the probable efficacy of vitamin D supplementation on SLE patients. We searched "Science Direct" and "Pub Med" using "Vitamin D" and "SLE" for finding the studies focusing on the association between vitamin D deficiency and SLE incidence and consequences. Evidences show that vitamin D plays an important role in the pathogenesis and progression of SLE and vitamin D supplementation seems to ameliorate inflammatory and hemostatic markers; so, can improve clinical subsequent.

Induced abortion among Brazilian female sex workers: a qualitative study.

PubMed

Madeiro, Alberto Pereira; Diniz, Debora

2015-02-01

Prostitutes are vulnerable to unplanned pregnancies and abortions. In Brazil, abortion is a crime and there is no data about unsafe abortions for this population. The study describes how prostitutes perform illegal abortions and the health consequences thereof. Semi-structured interviews with 39 prostitutes from three cities in Brazil with previous induced abortion experience were conducted. Sixty-six abortions, with between one and eight occurrences per woman, were recorded. The majority of the cases resulted from sexual activity with clients. The inconsistent use of condoms with regular clients and the consumption of alcohol during work were indicated as the main causes of unplanned pregnancies. The main method to perform abortion was the intravaginal and oral use of misoprostol, acquired in pharmacies or on the black market. Invasive measures were less frequently reported, however with more serious health complications. The fear of complaint to the police meant that most women do not inform the health team regarding induced abortion. The majority of prostitutes aborted with the use of illegally-acquired misoprostol, ending abortion in a public hospital with infection and hemorrhagic complications. The data indicate the need for a public policy focusing on the reproductive health of prostitutes.

The Role of Proanthocyanidins Complex in Structure and Nutrition Interaction in Alfalfa Forage

PubMed Central

Jonker, Arjan; Yu, Peiqiang

2016-01-01

Alfalfa (Medicago sativa L.) is one of the main forages grown in the world. Alfalfa is a winter hardy, drought tolerant, N-fixing legume with a good longevity, high yield, high nutrient levels, high digestibility, unique structural to non-structural components ratio, high dry matter intake, and high animal productivity per hectare. However, its main limitation is its excessively rapid initial rate of protein degradation in the rumen, which results in pasture bloat and inefficient use of protein with consequent excessive excretions of nitrogen into the environment. Proanthocyanidins are secondary plant metabolites that can bind with protein and thereby reduce the rate and extent of ruminal protein degradation. However, these secondary metabolites do not accumulate in alfalfa. This review aims to firstly describe the events involved in the rapid release of protein from alfalfa and its effect on ruminant nutrition, environmental pollution, and pasture bloat; secondly, to describe occurrence, structure, functions and benefits of moderate amounts of proanthocyanidin; and finally, to describe the development of alfalfa which accumulates moderate amounts of proanthocyanidins. The emphasis of this review focuses on the role of proanthocyanidins compounds in structure and nutrition interaction in ruminant livestock systems. PMID:27223279

The Role of Proanthocyanidins Complex in Structure and Nutrition Interaction in Alfalfa Forage.

PubMed

Jonker, Arjan; Yu, Peiqiang

2016-05-23

Alfalfa (Medicago sativa L.) is one of the main forages grown in the world. Alfalfa is a winter hardy, drought tolerant, N-fixing legume with a good longevity, high yield, high nutrient levels, high digestibility, unique structural to non-structural components ratio, high dry matter intake, and high animal productivity per hectare. However, its main limitation is its excessively rapid initial rate of protein degradation in the rumen, which results in pasture bloat and inefficient use of protein with consequent excessive excretions of nitrogen into the environment. Proanthocyanidins are secondary plant metabolites that can bind with protein and thereby reduce the rate and extent of ruminal protein degradation. However, these secondary metabolites do not accumulate in alfalfa. This review aims to firstly describe the events involved in the rapid release of protein from alfalfa and its effect on ruminant nutrition, environmental pollution, and pasture bloat; secondly, to describe occurrence, structure, functions and benefits of moderate amounts of proanthocyanidin; and finally, to describe the development of alfalfa which accumulates moderate amounts of proanthocyanidins. The emphasis of this review focuses on the role of proanthocyanidins compounds in structure and nutrition interaction in ruminant livestock systems.

Stitch modeling of non crimp fabric in forming simulations

NASA Astrophysics Data System (ADS)

Steer, Q.; Colmars, J.; Boisse, P.

2018-05-01

The use of Non Crimp Fabric composite has increased during the last years due to cheaper cost of manufacturing and high mechanicals properties suitable for applications such as aeronautic, automotive and wind turbines. The main difference between Non Crimp Fabric (NCF) and textile reinforcement is the mean of manufacturing: where in textile fibers are woven, in NCF layers of unidirectional oriented fibers are assembled with a stitch. As a consequence, the stitch especially its geometry (stitch pattern) will have a major influence on the deformation of this type of reinforcement during forming process. Experimental campaigns on NCF samples compared to textile with the same fibers orientation have showed that the stitch affects the shear behavior of the reinforcement which is the main mode of deformation in the forming process. A description of the stitch has been implemented in a shell element for macro scale forming simulation as a first approach based on simple hypothesis. Further works are focus on the specific behavior of the stitch along the fabric and interaction with the fibers layers during shear deformation of the reinforcement and a method to implement the stitch in a more refined model of the fabric.

Battery management systems (BMS) optimization for electric vehicles (EVs) in Malaysia

NASA Astrophysics Data System (ADS)

Salehen, P. M. W.; Su'ait, M. S.; Razali, H.; Sopian, K.

2017-04-01

Following the UN Climate Change Conference 2009 in Copenhagen, Denmark, Malaysia seriously committed on "Go Green" campaign with the aim to reduce 40% GHG emission by the year 2020. Therefore, the National Green Technology Policy has been legalised in 2009 with transportation as one of its focused sectors, which include hybrid (HEVs), electric vehicles (EVs) and fuel cell vehicles with the purpose of to keep up with the worst scenario. While the number of registered cars has been increasing by 1 million yearly, the amount has doubled in the last two decades. Consequently, CO2 emission in Malaysia reaches up to 97.1% and will continue to increase mainly due to the activities in the transportation sector. Nevertheless, Malaysia is now moving towards on green car which battery-based EVs. This type of transportation mainly needs power performance optimization, which is controlled by the Batteries Management System (BMS). BMS is an essential module which leads to reliable power management, optimal power performance and safe vehicle that lead back for power optimization in EVs. Thus, this paper proposes power performance optimization for various setups of lithium-ion cathode with graphene anode using MATLAB/SIMULINK software for better management performance and extended EVs driving range.

Dual fuel injection piggyback controller system

NASA Astrophysics Data System (ADS)

Muji, Siti Zarina Mohd.; Hassanal, Muhammad Amirul Hafeez; Lee, Chua King; Fawzi, Mas; Zulkifli, Fathul Hakim

2017-09-01

Dual-fuel injection is an effort to reduce the dependency on diesel and gasoline fuel. Generally, there are two approaches to implement the dual-fuel injection in car system. The first approach is changing the whole injector of the car engine, the consequence is excessive high cost. Alternatively, it also can be achieved by manipulating the system's control signal especially the Electronic Control Unit (ECU) signal. Hence, the study focuses to develop a dual injection timing controller system that likely adopted to control injection time and quantity of compressed natural gas (CNG) and diesel fuel. In this system, Raspberry Pi 3 reacts as main controller unit to receive ECU signal, analyze it and then manipulate its duty cycle to be fed into the Electronic Driver Unit (EDU). The manipulation has changed the duty cycle to two pulses instead of single pulse. A particular pulse mainly used to control injection of diesel fuel and another pulse controls injection of Compressed Natural Gas (CNG). The test indicated promising results that the system can be implemented in the car as piggyback system. This article, which was originally published online on 14 September 2017, contained an error in the acknowledgment section. The corrected acknowledgment appears in the Corrigendum attached to the pdf.

Risky riding behavior on two wheels: the role of cognitive, social, and personality variables among young adolescents.

PubMed

Falco, Alessandra; Piccirelli, Alessandra; Girardi, Damiano; Dal Corso, Laura; De Carlo, Nicola A

2013-09-01

The main objective of this study was to analyze and estimate the relations between risky riding behaviors and some personality and sociocognitive variables through structural equation modeling. We focused on two-wheel riding behavior among a sample of 1,028 Italian adolescents at their first driving experience. The main findings confirmed the role of personality in influencing riding behavior directly as well as indirectly through risk perception. In particular, risk perception was a significant mediator between personality, social norm, and riding behavior. The significant relations that emerged in the general sample were further confirmed in the two specific sub-samples of males and females. In terms of social marketing and educational communication, it may consequently be advisable to proceed in an integrated and coordinated manner at both the cognitive and social level, taking into account some "dispositions to risk" related to personality. The integrated and coordinated action on different levels--cognitive, social, and personality--may therefore allow more effective and significant results in reducing those risky riding behaviors that often underlie young two-wheel riders' higher involvement in traffic accidents. Copyright © 2013 National Safety Council and Elsevier Ltd. All rights reserved.

Experimental characterization of thermal and hygric properties of hemp concrete with consideration of the material age evolution

NASA Astrophysics Data System (ADS)

Bennai, F.; Issaadi, N.; Abahri, K.; Belarbi, R.; Tahakourt, A.

2018-04-01

The incorporation of plant crops in construction materials offers very good hygrothermal performance to the building, ensuring substantial environmental and ecological benefits. This paper focuses on studying the evolution of hygrothermal properties of hemp concrete over age (7, 30 and 60 days). The analysis is done with respect to two main hygric and thermal properties, respectively: sorption isotherms, water vapor permeability, thermal conductivity and heat capacity. In fact, most of these parameters are very susceptible to change function of the age of the material. This influence of the aging is mainly due to the evolution of the microstructure with the binder hydration over time and the creation of new hydrates which can reduces the porosity of the material and consequently modify its properties. All the tested hemp concrete samples presented high moisture storage capacity and high-water vapor permeability whatever the age of such hygroscopic material. These hygric parameters increase significantly for high relative humidity requiring more consideration of such variability during the modeling of coupled heat and mass transfer within the material. By the same, the thermal conductivity and heat capacity tests highlighted the impact of the temperature and hygric state of the studied material.

Vector independent transmission of the vector-borne bluetongue virus.

PubMed

van der Sluijs, Mirjam Tineke Willemijn; de Smit, Abraham J; Moormann, Rob J M

2016-01-01

Bluetongue is an economically important disease of ruminants. The causative agent, Bluetongue virus (BTV), is mainly transmitted by insect vectors. This review focuses on vector-free BTV transmission, and its epizootic and economic consequences. Vector-free transmission can either be vertical, from dam to fetus, or horizontal via direct contract. For several BTV-serotypes, vertical (transplacental) transmission has been described, resulting in severe congenital malformations. Transplacental transmission had been mainly associated with live vaccine strains. Yet, the European BTV-8 strain demonstrated a high incidence of transplacental transmission in natural circumstances. The relevance of transplacental transmission for the epizootiology is considered limited, especially in enzootic areas. However, transplacental transmission can have a substantial economic impact due to the loss of progeny. Inactivated vaccines have demonstrated to prevent transplacental transmission. Vector-free horizontal transmission has also been demonstrated. Since direct horizontal transmission requires close contact of animals, it is considered only relevant for within-farm spreading of BTV. The genetic determinants which enable vector-free transmission are present in virus strains circulating in the field. More research into the genetic changes which enable vector-free transmission is essential to better evaluate the risks associated with outbreaks of new BTV serotypes and to design more appropriate control measures.

Review on Lithotripsy and Cavitation in Urinary Stone Therapy.

PubMed

Ghorbani, Morteza; Oral, Ozlem; Ekici, Sinan; Gozuacik, Devrim; Kosar, Ali

2016-01-01

Cavitation is the sudden formation of vapor bubbles or voids in liquid media and occurs after rapid changes in pressure as a consequence of mechanical forces. It is mostly an undesirable phenomenon. Although the elimination of cavitation is a major topic in the study of fluid dynamics, its destructive nature could be exploited for therapeutic applications. Ultrasonic and hydrodynamic sources are two main origins for generating cavitation. The purpose of this review is to give the reader a general idea about the formation of cavitation phenomenon and existing biomedical applications of ultrasonic and hydrodynamic cavitation. Because of the high number of the studies on ultrasound cavitation in the literature, the main focus of this review is placed on the lithotripsy techniques, which have been widely used for the treatment of urinary stones. Accordingly, cavitation phenomenon and its basic concepts are presented in Section II. The significance of the ultrasound cavitation in the urinary stone treatment is discussed in Section III in detail and hydrodynamic cavitation as an important alternative for the ultrasound cavitation is included in Section IV. Finally, side effects of using both ultrasound and hydrodynamic cavitation in biomedical applications are presented in Section V.

Assessing the consequences of nonnative trout in headwater ecosystems in western North America

Treesearch

Jason B. Dunham; David S. Pilliod; Michael K. Young

2004-01-01

Intentional introductions of nonnative trout into headwater lakes and streams can have numerous effects on the receiving ecosystems, potentially threatening native species and disrupting key ecological processes. In this perspective, we focus on seven key issues for assessing the biological and economic consequences of nonnative trout in headwater ecosystems: (1)...

University Student Perceptions about the Motives for and Consequences of Nonmedical Use of Prescription Drugs (NMUPD)

ERIC Educational Resources Information Center

Parks, Kathleen A.; Levonyan-Radloff, Kristine; Przybyla, Sarahmona M.; Darrow, Sherri; Muraven, Mark; Hequembourg, Amy

2017-01-01

Objective: The purpose of the current study was to increase qualitative understanding of student motives for and consequences associated with nonmedical use of prescription drugs. Participants: Sixty-one students participated in eight focus groups between April and November 2013. Methods: Students described prescription drugs commonly used for…

Europe '92: Consequences of the European Unification for Cultural Federalism in the Federal Republic of Germany.

ERIC Educational Resources Information Center

Berggreen, Ingeborg

1990-01-01

Discusses consequences of European unification in the Federal Republic of Germany. Focuses on the relationships between the European Community, the federal government of Germany, and the German states. Suggests that the German states are aware of their responsibility to give education and culture a European dimension. (NL)

Using a Hierarchy of Supportive Consequences to Address Problem Behaviors in the Classroom

ERIC Educational Resources Information Center

Leach, Debra; Helf, Shawnna

2016-01-01

Many educators across the country are implementing positive behavioral interventions and supports (PBIS) in their schools and classrooms. While PBIS primarily focuses on proactive and preventative approaches to improve behavior, one of the essential elements of PBIS is the consistent use of consequences when students do not meet behavioral…

Some Determinants and Consequences of Helping by the Elderly.

ERIC Educational Resources Information Center

Midlarsky, Elizabeth; Kahana, Eva

Research on helping behavior has focused on help to elderly individuals rather than help by elderly individuals. To investigate the determinants and consequences of helping by older adults, 117 adults, from five Detroit senior citizen residences, with a mean age of 75.6 (67 percent female) completed a personal/demographic questionnaire, including…

Child-Related Interparental Conflict in Infancy Predicts Child Cognitive Functioning in a Nationally Representative Sample

ERIC Educational Resources Information Center

Pendry, Patricia; Adam, Emma K.

2013-01-01

While associations between exposure to marital conflict and child development have been documented extensively in middle childhood and adolescence, few studies have examined the developmental consequences of conflict exposure in infancy. Moreover, those that have examined marital conflict in infancy tended to focus on consequences of conflict…

Pathological anxiety in animals.

PubMed

Ohl, Frauke; Arndt, Saskia S; van der Staay, F Josef

2008-01-01

Selective breeding programmes in domestic and laboratory animals generally focus on physiological and/or anatomical characteristics. However, selection may have an (unintended) impact on other characteristics and may lead to dysfunctional behaviour that can affect biological functioning and, as a consequence, compromise welfare and quality of life. In this review it is proposed that various behavioural dysfunctions in animals are due to pathological anxiety. Although several approaches have been undertaken to specify the diagnostic criteria of pathological anxiety as a behavioural disorder in animals, the causal aetiology largely remains unknown. This is mainly due to the fact that integrated concepts, combining the behavioural syndrome and (neuro-) physiological processes, are widely lacking. Moreover, even the term anxiety itself represents a poorly defined concept or category. A definition is suggested and the potential causes of pathological anxiety are explored with a plea for developing adequate diagnostic tools and therapies to fight pathological anxiety in animals based on insight from scientific research.

The physical impacts of microplastics on marine organisms: a review.

PubMed

Wright, Stephanie L; Thompson, Richard C; Galloway, Tamara S

2013-07-01

Plastic debris at the micro-, and potentially also the nano-scale, are widespread in the environment. Microplastics have accumulated in oceans and sediments worldwide in recent years, with maximum concentrations reaching 100 000 particles m(3). Due to their small size, microplastics may be ingested by low trophic fauna, with uncertain consequences for the health of the organism. This review focuses on marine invertebrates and their susceptibility to the physical impacts of microplastic uptake. Some of the main points discussed are (1) an evaluation of the factors contributing to the bioavailability of microplastics including size and density; (2) an assessment of the relative susceptibility of different feeding guilds; (3) an overview of the factors most likely to influence the physical impacts of microplastics such as accumulation and translocation; and (4) the trophic transfer of microplastics. These findings are important in guiding future marine litter research and management strategies. Copyright © 2013 Elsevier Ltd. All rights reserved.

Organisational performance and business continuity management: a theoretical perspective and a case study.

PubMed

Sawalha, Ihab Hanna Salman

2013-01-01

This paper seeks to extend the research relating to the strategic view of business continuity management (BCM) to the context of organisational performance (OP). It discusses potential performance consequences resulting from applying BCM aspects/elements within an organisation. The paper contributes to the understanding of the role of BCM in OP by discussing how deployment of BCM key aspects/elements can improve OP. Two main issues are discussed: first, background to performance and the elements of OP; and secondly, the role of BCM in achieving optimised OP. These issues are significant, as they go further than the extant literature relating to the significance of BCM and its potential influence on OP. The study focuses on Jordanian banks as a case study and as a way of illustrating how BCM helps improve OP for those organisations facing performance shortcomings or difficulties.

Controller design for a teleoperator system with dissimilar kinematics and force feedback

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jansen, J.F.; Kress, R.L.; Babcock, S.M.

1990-01-01

The purpose of this paper is to develop a controller for dissimilar kinematic teleoperator systems, which include a force/torque sensor mounted on the slave. Due to improved modern microprocessor computing capability and the trend toward redundant slaves, the next generation of teleoperator systems will likely incorporate dissimilar kinematics in their design; consequently, a need exists for a workable control scheme for these systems. The control scheme presented in this paper incorporates the work and ideas of numerous researchers over the past 40 years. The master controller and the orientation representation using Euler parameters for the both the master and slavemore » will be the main focus of this paper. The implementation of the master controller on a 6-degrees-of-freedom (DOF) master is also discussed. Only a brief summary of the overall strategy will be presented. 13 refs., 1 fig.« less

Therapies in early development for the treatment of urinary tract inflammation.

PubMed

Zacchè, Martino Maria; Giarenis, Ilias

2016-01-01

Urinary tract inflammation is a very common clinical condition. It is caused by several pathogens and antibiotic treatment is the mainstay of therapy. Increasing antimicrobial resistance and high recurrence rates represent a challenge. Consequently, there is an unmet need for new therapeutic options. The authors discuss the rationale of emerging management strategies and current experimentation. Furthermore, they focus on both acute and recurrent urinary tract infections (UTIs) and examine a range of therapeutics, including new antibiotics, vaccines, mannosides, hyaluronic acid, probiotics, immunomodulant agents and novel compounds derived from nanotechnology. Basic science studies have elucidated the pathogenesis of UTIs and built up the ground for the development of new therapies. Evidence is mainly derived from animal studies on murine models of bacterial cystitis. However, clinical trials are scanty and cannot provide us with robust evidence. Hetereogeneity and virulence of uropathogens pose a threat that scientists and clinicians are struggling to overcome.

Building and testing models with extended Higgs sectors

NASA Astrophysics Data System (ADS)

Ivanov, Igor P.

2017-07-01

Models with non-minimal Higgs sectors represent a mainstream direction in theoretical exploration of physics opportunities beyond the Standard Model. Extended scalar sectors help alleviate difficulties of the Standard Model and lead to a rich spectrum of characteristic collider signatures and astroparticle consequences. In this review, we introduce the reader to the world of extended Higgs sectors. Not pretending to exhaustively cover the entire body of literature, we walk through a selection of the most popular examples: the two- and multi-Higgs-doublet models, as well as singlet and triplet extensions. We will show how one typically builds models with extended Higgs sectors, describe the main goals and the challenges which arise on the way, and mention some methods to overcome them. We will also describe how such models can be tested, what are the key observables one focuses on, and illustrate the general strategy with a subjective selection of results.

Valuing improved wetland quality using choice modeling

NASA Astrophysics Data System (ADS)

Morrison, Mark; Bennett, Jeff; Blamey, Russell

1999-09-01

The main stated preference technique used for estimating environmental values is the contingent valuation method. In this paper the results of an application of an alternative technique, choice modeling, are reported. Choice modeling has been developed in the marketing and transport applications but has only been used in a handful of environmental applications, most of which have focused on use values. The case study presented here involves the estimation of the nonuse environmental values provided by the Macquarie Marshes, a major wetland in New South Wales, Australia. Estimates of the nonuse value the community places on preventing job losses are also presented. The reported models are robust, having high explanatory power and variables that are statistically significant and consistent with expectations. These results provide support for the hypothesis that choice modeling can be used to estimate nonuse values for both environmental and social consequences of resource use changes.

Mental Health Consumer Experiences and Strategies When Seeking Physical Health Care

PubMed Central

Ewart, Stephanie B.; Bocking, Julia; Happell, Brenda; Platania-Phung, Chris; Stanton, Robert

2016-01-01

People with mental illness have higher rates of physical health problems and consequently live significantly shorter lives. This issue is not yet viewed as a national health priority and research about mental health consumer views on accessing physical health care is lacking. The aim of this study is to explore the experience of mental health consumers in utilizing health services for physical health needs. Qualitative exploratory design was utilized. Semistructured focus groups were held with 31 consumer participants. Thematic analysis revealed that three main themes emerged: scarcity of physical health care, with problems accessing diagnosis, advice or treatment for physical health problems; disempowerment due to scarcity of physical health care; and tenuous empowerment describing survival resistance strategies utilized. Mental health consumers were concerned about physical health and the nonresponsive health system. A specialist physical health nurse consultant within mental health services should potentially redress this gap in health care provision. PMID:28462330

Assistive technologies along supply chains in health care and in the social services sector.

PubMed

Mayer, Peter; Hauer, Katharina; Schloffer, Evelyn; Leyrer, Barbara

2015-01-01

Health care systems in Austria and Slovenia are currently facing challenges due to scarce resources and demographic change which can be seen especially along the supply chains. The main objective of this paper is to present an option to improve the use of assistive technologies. An extensive literature research for the theoretic part as well as a qualitative survey for the empiric part focusing on short-term care were carried out. Results show that there is a lack of information and training on assistive technologies. As a consequence, their full potential cannot be exploited. Therefore a guideline for nursing consultations was developed. To conclude, both the literature research and the qualitative survey show that assistive technologies have high potentials to improve the supply chains in the health care and social services sector, but there is a lot of information and training on them needed.

[G-DRG system 2009: relevant changes for rheumatology].

PubMed

Fiori, W; Liedtke-Dyong, A; Lakomek, H-J; Buscham, K; Lehmann, H; Liman, W; Fuchs, A-K; Bessler, F; Roeder, N

2009-08-01

The following article presents the main general and specific changes in the G-DRG (German diagnosis-related groups) system in terms of the classification systems for diagnoses and procedures as well as the billing process for 2009. Of fundamental relevance is the national weighting of the G-DRG I97Z (complex rheumatologic treatment), which up to now had to be negotiated individually by each hospital. Emphasis is also put on case auditing by the health insurers. Being primarily a tool for redistribution of resources, every hospital has to analyze the economic effects of the 2009 G-DRG system by applying the G-DRG transition grouper to its own cases. Depending on their clinical focus rheumatological departments may experience positive or negative consequences from the development. The strain imposed on hospitals by inadequate refunding of rising costs has to be assessed separately from the effects of redistribution by the G-DRG system.

Steroid dysregulation and stomatodynia (burning mouth syndrome).

PubMed

Woda, Alain; Dao, Thuan; Gremeau-Richard, Christelle

2009-01-01

Stomatodynia ( burning mouth syndrome) is characterized by a spontaneous, continuous burning pain felt in the oral mucosa typically of anxiodepressive menopausal women. Because there is no obvious organic cause, it is considered a nonspecific pain. This Focus Article proposes a hypothesis based on the following pathophysiological cascade: chronic anxiety or post traumatic stress leads to a dysregulation of the adrenal production of steroids. One consequence is a decreased or modified production of some major precursors for the neuroactive steroid synthesis occurring in the skin, mucosa, and nervous system. At menopause, the drastic fall of the other main precursor supply , the gonadal steroids, leads to a brisk alteration of the production of neuroactive steroids. This results in neurodegenerative alterations of small nerves fibers of the oral mucosa and /or some brain areas involved in oral somatic sensations. These neuropathic changes become irreversible and precipitate the burning pain, dysgeusia, and xerostomia associated with stomatodynia, which all involve thin nerve fibers.

The management of hemophilia in elderly patients

PubMed Central

Franchini, Massimo; Tagliaferri, Annarita; Mannucci, Pier Mannuccio

2007-01-01

After the increasing rate of deaths observed during the 1980s due to human immunodeficiency virus (HIV) infection, the health-related quality of life and life expectancy of persons with hemophilia have improved, mainly due to the progresses of replacement therapy and antiviral drugs and to the improvement of the global comprehensive care provided by specialized centers. As a consequence, an increasing number of hemophiliacs have reached an older age and nowadays physicians in hemophilia centers find that they must handle age-related clinical problems never previously observed in this population. The management of elderly persons with congenital hemophilia is discussed in the first part of this review. The second part describes the general aspects of acquired hemophilia due to anti-factor VIII autoantibodies, focusing on the clinical management of elderly patients, one of the groups most frequently affected by this acquired bleeding disorder. PMID:18044186

Challenges and benefits of conducting environmental justice research in a school setting.

PubMed

Guidry, Virginia T; Lowman, Amy; Hall, Devon; Baron, Dothula; Wing, Steve

2014-01-01

Environmental justice (EJ) research requires attention to consequences for research participants beyond those typically considered by institutional review boards. The imbalance of power between impacted communities and those who create and regulate pollution creates challenges for participation, yet research can also benefit those involved. Our community-academic partnership designed the Rural Air Pollutants and Children's Health (RAPCH) study to provide positive impacts while measuring health effects at three low-resource public middle schools near concentrated animal feeding operations (CAFOs) in North Carolina. We evaluated perceived benefits and challenges of study involvement by interviewing school staff and community liaisons who facilitated data collection. Reported benefits included enhancement of students' academic environment and increased community environmental awareness; challenges were associated mainly with some participants' immaturity. Leadership from a strong community-based organization was crucial to recruitment, yet our approach entailed minimal focus on EJ, which may have limited opportunities for community education or organizing for environmental health.

Biomedical Applications of Nanodiamonds: An Overview.

PubMed

Passeri, D; Rinaldi, F; Ingallina, C; Carafa, M; Rossi, M; Terranova, M L; Marianecci, C

2015-02-01

Nanodiamonds are a novel class of nanomaterials which have raised much attention for application in biomedical field, as they combine the possibility of being produced on large scale using relatively inexpensive synthetic processes, of being fluorescent as a consequence of the presence of nitrogen vacancies, of having their surfaces functionalized, and of having good biocompatibility. Among other applications, we mainly focus on drug delivery, including cell interaction, targeting, cancer therapy, gene and protein delivery. In addition, nanodiamonds for bone and dental implants and for antibacterial use is discussed. Techniques for detection and imaging of nanodiamonds in biological tissues are also reviewed, including electron microscopy, fluorescence microscopy, Raman mapping, atomic force microscopy, thermal imaging, magnetic resonance imaging, and positron emission tomography, either in vitro, in vivo, or ex vivo. Toxicological aspects related to the use of nanodiamonds are also discussed. Finally, patents, preclinical and clinical trials based on the use of nanodiamonds for biomedical applications are reviewed.

Work-related behaviour and experience pattern in nurses: impact on physical and mental health.

PubMed

Schulz, M; Damkröger, A; Voltmer, E; Löwe, B; Driessen, M; Ward, M; Wingenfeld, K

2011-06-01

Nursing is associated with high levels of emotional strain and heavy workloads. Changing working conditions raise the importance of investigating job satisfaction, stress and burnout and its consequences for nurses. The aim of the study was to investigate whether work-related behaviour and experience patterns are associated with mental and physical health status in nurses. A sample of 356 nurses in four German hospitals were interviewed using questionnaires regarding work-related behaviour and experience patterns, work stress, depression, anxiety and physical symptoms ('Work-related Behaviour and Experience Pattern'--AVEM and ERI). The main result of this study is that unhealthy work-related behaviour and experience patterns (i.e. the excessive ambitious type and the resigned type) are associated with reduced mental and physical health. Preventive, as well as intervention, strategies are needed that focus both on the individual as well as on working conditions. © 2011 Blackwell Publishing.

Creep-Fatigue Failure Diagnosis

PubMed Central

Holdsworth, Stuart

2015-01-01

Failure diagnosis invariably involves consideration of both associated material condition and the results of a mechanical analysis of prior operating history. This Review focuses on these aspects with particular reference to creep-fatigue failure diagnosis. Creep-fatigue cracking can be due to a spectrum of loading conditions ranging from pure cyclic to mainly steady loading with infrequent off-load transients. These require a range of mechanical analysis approaches, a number of which are reviewed. The microstructural information revealing material condition can vary with alloy class. In practice, the detail of the consequent cracking mechanism(s) can be camouflaged by oxidation at high temperatures, although the presence of oxide on fracture surfaces can be used to date events leading to failure. Routine laboratory specimen post-test examination is strongly recommended to characterise the detail of deformation and damage accumulation under known and well-controlled loading conditions to improve the effectiveness and efficiency of failure diagnosis. PMID:28793676

A revision of Artemia biodiversity in Macaronesia

PubMed Central

2012-01-01

In a biogeographical context, the term Macaronesia broadly embraces the North Atlantic archipelagos of the Azores, Madeira, Selvagens, the Canary Islands, and Cape Verde. The peculiar arid climatic conditions in some of these places have led to the development of marine salt exploitations, which can be counted among the hypersaline habitats of the brine shrimp Artemia (Branchiopoda, Anostraca). Parthenogenetic populations of this anostracan were described in the Canary Islands during the last decades of the 20th century, while the American Artemia franciscana species was recently found in the Cape Verde archipelago. Following an invasive pattern, this exotic species has recently reached the Canary Islands, too. This paper reports information dealing with biotope loss (solar saltworks) in this biogeographical region, together with possible consequences concerning the arrival of invasive species, two factors that frequently promote dramatic biodiversity losses. The discussion of this threat focuses mainly on the Canary Islands archipelago where native species of Artemia still exist. PMID:23075404

The emergence of consensus: a primer

PubMed Central

2018-01-01

The origin of population-scale coordination has puzzled philosophers and scientists for centuries. Recently, game theory, evolutionary approaches and complex systems science have provided quantitative insights on the mechanisms of social consensus. However, the literature is vast and widely scattered across fields, making it hard for the single researcher to navigate it. This short review aims to provide a compact overview of the main dimensions over which the debate has unfolded and to discuss some representative examples. It focuses on those situations in which consensus emerges ‘spontaneously’ in the absence of centralized institutions and covers topics that include the macroscopic consequences of the different microscopic rules of behavioural contagion, the role of social networks and the mechanisms that prevent the formation of a consensus or alter it after it has emerged. Special attention is devoted to the recent wave of experiments on the emergence of consensus in social systems. PMID:29515905

Subcellular characteristics of functional intracellular renin–angiotensin systems☆

PubMed Central

Abadir, Peter M.; Walston, Jeremy D.; Carey, Robert M.

2013-01-01

The renin–angio tensin system (RAS) is now regarded as an integral component in not only the development of hypertension, but also in physiologic and pathophysiologic mechanisms in multiple tissues and chronic disease states. While many of the endocrine (circulating), paracrine (cell-to-different cell) and autacrine (cell-to-same cell) effects of the RAS are believed to be mediated through the canonical extracellular RAS, a complete, independent and differentially regulated intracellular RAS (iRAS) has also been proposed. Angiotensinogen, the enzymes renin and angiotensin-converting enzyme (ACE) and the angiotensin peptides can all be synthesized and retained intracellularly. Angiotensin receptors (types I and 2) are also abundant intracellularly mainly at the nuclear and mitochondrial levels. The aim of this review is to focus on the most recent information concerning the subcellular localization, distribution and functions of the iRAS and to discuss the potential consequences of activation of the subcellular RAS on different organ systems. PMID:23032352

Electronic Certification of Death in Slovenia - System Considerations and Development Opportunities.

PubMed

Stanimirovic, Dalibor

2016-01-01

Accurate and consistent death certification facilitates morbidity and mortality surveillance, and consequently supports evidence-informed health policies. The paper initially explores the current death certification practice in Slovenia, and identifies related deficiencies and system inconsistencies. Finally, the paper outlines a conceptualization of ICT-based model of death certification including renovation of business processes and organizational changes. The research is based on focus group methodology. Structured discussions were conducted with 29 experts from cross-sectional areas related to death certification. Research results imply that effective ICT-based transformation of the existing death certification model should involve a redefinition of functions and relationships between the main actors, as well as a reconfiguration of the technological, organizational, and regulatory elements in the field. The paper provides an insight into the complexities of the death certification and may provide the groundwork for ICT-based transformation of the death certification model in Slovenia.

The emergence of consensus: a primer

NASA Astrophysics Data System (ADS)

Baronchelli, Andrea

2018-02-01

The origin of population-scale coordination has puzzled philosophers and scientists for centuries. Recently, game theory, evolutionary approaches and complex systems science have provided quantitative insights on the mechanisms of social consensus. However, the literature is vast and widely scattered across fields, making it hard for the single researcher to navigate it. This short review aims to provide a compact overview of the main dimensions over which the debate has unfolded and to discuss some representative examples. It focuses on those situations in which consensus emerges `spontaneously' in the absence of centralized institutions and covers topics that include the macroscopic consequences of the different microscopic rules of behavioural contagion, the role of social networks and the mechanisms that prevent the formation of a consensus or alter it after it has emerged. Special attention is devoted to the recent wave of experiments on the emergence of consensus in social systems.

Traumatic brain injury: a risk factor for neurodegenerative diseases.

PubMed

Gupta, Rajaneesh; Sen, Nilkantha

2016-01-01

Traumatic brain injury (TBI), a major global health and socioeconomic problem, is now established as a chronic disease process with a broad spectrum of pathophysiological symptoms followed by long-term disabilities. It triggers multiple and multidirectional biochemical events that lead to neurodegeneration and cognitive impairment. Recent studies have presented strong evidence that patients with TBI history have a tendency to develop proteinopathy, which is the pathophysiological feature of neurodegenerative disorders such as Alzheimer disease (AD), chronic traumatic encephalopathy (CTE), and amyotrophic lateral sclerosis (ALS). This review mainly focuses on mechanisms related to AD, CTE, and ALS that are induced after TBI and their relevance to the advancement of these neurodegenerative diseases. This review encompasses acute effects and chronic neurodegenerative consequences after TBI for a better understanding of TBI-induced neuronal death and to design therapies that will effectively treat patients in the primary or secondary progressive stages.

Growth factors, stem cells and bronchopulmonary dysplasia.

PubMed

Alphonse, Rajesh S; Thébaud, Bernard

2011-01-01

Bronchopulmonary dysplasia (BPD) is the chronic lung disease of prematurity mainly affecting preterm infants that are born at 24-28 weeks of gestation. Surfactant therapy, antenatal steroids and incremental improvements in perinatal care have modified the pattern of injury and allowed survival of ever more immature infants, but there is still no specific treatment for BPD. As a consequence, this disorder remains the most common complication of extreme prematurity. Arrested alveolar growth and disrupted vasculogenesis, the histological hallmarks of BPD, may persist beyond childhood and lead to chronic lung diseases in adults. Recent advances in our understanding of stem cells and their potential to repair damaged organs offer the possibility for cell-based treatment for intractable diseases. This review summarizes basic concepts of stem cell biology and discusses the recent advances and challenges of stem cell-based therapies for lung diseases, with a particular focus on BPD. Copyright © 2011 S. Karger AG, Basel.

[Mentalization and theory of mind].

PubMed

Wyl, Agnes

2014-01-01

Both concepts, mentalization and the theory of mind, describe metacognitive processes. Mentalization mainly concerns the reflection of affective mental states. In contrast, theory of mind focuses on epistemic states such as beliefs, intentions and persuasions. Gender differences have proved to be relevant for both, the development of mentalization and the theory of mind. However, there are few studies and findings are inconsistent. In an own study, we investigated the relationship between early competences in metacognition (tested in a false-belief-task second order) and narrative skills of kindergarten children. Results show that children who had successfully passed the theory of mind test tended to face conflicts more directly in the stories. In consequence, these children showed less narrative avoidance. However, differences were only found in girls and not in boys. The precise understanding of developmental differences in metacognition between girls and boys may be an important aspect with regards to improving mentalization based therapy of children.

MEXICAN AMERICAN YOUTH AND ADULT PRISON GANGS IN A CHANGING HEROIN MARKET

PubMed Central

Valdez, Avelardo

2010-01-01

This article focuses on the interaction between the larger community’s drug markets and youth and adult prison gangs, and the process that leads to specific adverse consequences both to the youth gangs as organizations, and to individual members. Described is the emergence of a restructured heroin market dominated by an adult prison gang. A major consequence of this was the increasing use of heroin among Mexican American gang members and their transformation from autonomous youth gangs to extensions of the adult prison gangs or their demise. Data was collected from 160 members of 26 Mexican American youth gangs and key informants in San Antonio. Findings focus on organizational rules, drug market transformations, consequences on members, and the impact of heroin on the gang’s organization. Discussed is how the dominance of prison gangs is related to the increased incarceration and recidivism rates of Mexican Americans and declining economic opportunities for urban minorities. PMID:21614143

Predicting Consequences of Technological Disasters from Natural Hazard Events: Challenges and Opportunities Associated with Industrial Accident Data Sources

NASA Astrophysics Data System (ADS)

Wood, M.

2009-04-01

The increased focus on the possibility of technological accidents caused by natural events (Natech) is foreseen to continue for years to come. In this case, experts in prevention, mitigation and preparation activities associated with natural events will increasingly need to borrow data and expertise traditionally associated with the technological fields to carry out the work. An important question is how useful is the data for understanding consequences from such natech events. Data and case studies provided on major industrial accidents tend to focus on lessons learned for re-engineering the process. While consequence data are reported at least nominally in most reports, their precision, quality and completeness is often lacking. Consequences that are often or sometimes available but not provided can include severity and type of injuries, distance of victims from the source, exposure measurements, volume of the release, population in potentially affected zones, and weather conditions. Yet these are precisely the type of data that will aid natural hazard experts in land-use planning and emergency response activities when a Natech event may be foreseen. This work discusses the results of a study of consequence data from accidents involving toxic releases reported in the EU's MARS accident database. The study analysed the precision, quality and completeness of three categories of consequence data reported: the description of health effects, consequence assessment and chemical risk assessment factors, and emergency response information. This work reports on the findings from this study and discusses how natural hazards experts might interact with industrial accident experts to promote more consistent and accurate reporting of the data that will be useful in consequence-based activities.

Is the Medium Really the Message? A Comparison of Face-to-Face, Telephone, and Internet Focus Group Venues

ERIC Educational Resources Information Center

Gothberg, June; Applegate, Brooks; Reeves, Patricia; Kohler, Paula; Thurston, Linda; Peterson, Lori

2013-01-01

With increased use of technology in qualitative research, it is important to understand unintended, unanticipated, and unobvious consequences to the data. Using a side-by-side comparison of face-to-face, telephone, and Internet with video focus groups, we examined the yield differences of focus group venue (medium) to the data (message) rendered…

Is there a Space for Post-Colonial Theory in the Socio-Psychological Research on Consequences of Colonial Past?

PubMed

Leone, Giovanna

2018-04-26

The focus of my commentary is two-fold. First, I discuss what appeared to me as the central theoretical focus of the article; the possibility to create a space, if at all, for integrating post-colonial theory into the broader research field of social and psychological studies of the consequences of colonial past. Second, I intend to show why, in my opinion, the methodological choices of the authors and the criteria adopted for corpus construction allowed for data that, although too thin to establishing the state of knowledge in the field of study on consequences of colonial past, is nevertheless very informative and thoughts-provoking. My conclusions suggest that this study is an innovative attempt at describing and grasping the results of a search guided by two among the more consolidated electronic datasets currently available for English-speaking scholars. However, this study may not easily understand which can be the space to integrate post-colonial theory in the field of research on consequences of colonial past. To better reach this aim, it is perhaps necessary to build another kind of corpus, open to other languages (starting from French) and focused also on other scientific products, as books or proceedings of congress. In addition, disciplinary boundaries have to be even more explored, starting from interdisciplinary studies on education and historical culture. In spite of these limitations, I am convinced that this innovative study by Tomicic and Berardi tackles issues of relevance to any serious effort towards reflecting on long-term consequences of colonial violence and opens up to valuable new research questions and methods, to be taken into serious account and further explored in future works.

Columbus safety and reliability

NASA Astrophysics Data System (ADS)

Longhurst, F.; Wessels, H.

1988-10-01

Analyses carried out to ensure Columbus reliability, availability, and maintainability, and operational and design safety are summarized. Failure modes/effects/criticality is the main qualitative tool used. The main aspects studied are fault tolerance, hazard consequence control, risk minimization, human error effects, restorability, and safe-life design.

75 FR 37811 - Agency Information Collection Request; 30-Day Public Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-30

... respondent response In-depth interview screening 500 1 10/60 83 In-depth interview main interview 360 1 1 360 Focus group screening 800 1 10/60 133 Focus group main interview 400 1 2 800 Web-based message testing main interview........ 660 1 1 660 Omnibus survey questions main interview......... 4,000 1 10/60 667...

75 FR 19974 - Agency Information Collection Request. 60-Day Public Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-16

... response hours In-depth interview screening 500 1 10/60 83 In-depth interview main interview 360 1 1 360 Focus group screening 800 1 10/60 133 Focus group main interview 400 1 2 800 Web-based message testing main interview........ 660 1 1 660 Omnibus survey questions main interview......... 4,000 1 10/60 667...

Observational Consequences of an Interacting Multiverse

NASA Astrophysics Data System (ADS)

Robles-Pérez, Salvador

2017-05-01

The observability of the multiverse is at the very root of its physical significance as a scientific proposal. In this conference we present, within the third quantization formalism, an interacting scheme between the wave functions of different universes and analyze the effects of some particular values of the coupling function. One of the main consequences of the interaction between universes can be the appearance of a pre-inflationary stage in the evolution of the universes that might leave observable consequences in the properties of the CMB.

Pitfalls in Teaching Judgment Heuristics

ERIC Educational Resources Information Center

Shepperd, James A.; Koch, Erika J.

2005-01-01

Demonstrations of judgment heuristics typically focus on how heuristics can lead to poor judgments. However, exclusive focus on the negative consequences of heuristics can prove problematic. We illustrate the problem with the representativeness heuristic and present a study (N = 45) that examined how examples influence understanding of the…

Rumination, depressive symptoms and awareness of illness in schizophrenia.

PubMed

Thomas, Neil; Ribaux, Darryl; Phillips, Lisa J

2014-03-01

Depressive symptoms are common in schizophrenia. Previous studies have observed that depressive symptoms are associated with both insight and negative appraisals of illness, suggesting that the way in which the person thinks about their illness may influence the occurrence of depressive responses. In affective disorders, one of the most well-established cognitive processes associated with depressive symptoms is rumination, a pattern of perseverative, self-focused negative thinking. This study examined whether rumination focused on mental illness was predictive of depressive symptoms during the subacute phase of schizophrenia. Forty participants with a diagnosis of schizophrenia and in a stable phase of illness completed measures of rumination, depressive symptoms, awareness of illness, and positive and negative symptoms. Depressive symptoms were correlated with rumination, including when controlling for positive and negative symptoms. The content of rumination frequently focused on mental illness and its causes and consequences, in particular social disability and disadvantage. Depressive symptoms were predicted by awareness of the social consequences of mental illness, an effect that was mediated by rumination. Results suggest that a process of perseveratively dwelling upon mental illness and its social consequences may be a factor contributing to depressive symptoms in people with chronic schizophrenia.

Women, Anger Expression, Relational and Health Consequences: A Review of the Literature.

ERIC Educational Resources Information Center

McPherson, Kristin L.

Women's anger expression style has been the focus of several recent studies and has been demonstrated to have deleterious effects on emotional and physical health. The purpose of this study was to review the empirical literature for women's anger expression style and related health and relational consequences. The study reviewed emotion induction,…

Tracing Consequences of Policy Action: A Basis for Disadvantage Arguments.

ERIC Educational Resources Information Center

Baker, David P.

1984-01-01

The growth in the popularity and importance of disadvantage arguments in debate has been, in some measure, due to the growing belief that debate should be viewed from a policy-making perspective. And, with the focus of contemporary debate shifting to the consequences of policy actions, there has been a concurrent increase in the sophistication of…

Some Consequences of Changing People's Views Regarding the Nature of Mental Illness

ERIC Educational Resources Information Center

Farina, Amerigo; And Others

1978-01-01

The major focus of the three studies reported was the consequences of changing public conceptions of mental illness for the sufferer and his family. In two identically performed studies, two messages (one describing mental illness as a disease and the other as a product of social learning) were effective in changing beliefs. (Editor/RK)

Divorce and Adult Psychological Well-Being: Clarifying the Role of Gender and Child Age

ERIC Educational Resources Information Center

Williams, Kristi; Dunne-Bryant, Alexandra

2006-01-01

Substantial evidence indicates that marital dissolution has negative consequences for adult well-being. Because most research focuses on the average consequences of divorce, we know very little about factors that moderate this association. The present study tests the hypothesis that the effects of marital dissolution on adult well-being are…

Planning Skills and Negotiator Goal Accomplishment: The Relationship between Self-Monitoring and Plan Generation, Plan Enactment, and Plan Consequences.

ERIC Educational Resources Information Center

Jordan, Jerry Monroe; Roloff, Michael E.

1997-01-01

Focuses on skills necessary for effective negotiation planning. Argues that the information processing tendencies of high self-monitors make them adept at negotiation planning. Extends existing work by relating self-monitoring to plan generation, enactment, and consequences. Indicates that self-monitoring is related to prenegotiation goal…

Critical Reflection on the Massification of Higher Education in Korea: Consequences for Graduate Employment and Policy Issues

ERIC Educational Resources Information Center

Yeom, Min-ho

2016-01-01

The paper critically reviews the results of Korean massification in higher education (HE) and focuses on the consequences related to graduate employment. By analysing statistical data and reviewing related articles, this study explores the process of the massification of HE, investigates major factors influencing the expansion, and analyses and…

The Health Consequences of Smoking for Women. A Report of the Surgeon General 1979.

ERIC Educational Resources Information Center

Pinney, John M., Ed.; And Others

This report focuses on the evidence about the health consequences of smoking for women, and is intended to serve the public health and medical communities as a unified source of existing scientific research. The major issues about tobacco use and women's health are examined, including trends in consumption, biomedical evidence, and determinants of…

Alcohol Use in Adolescents. The Scope of the Problem and Strategies for Intervention.

ERIC Educational Resources Information Center

Schwenk, Thomas L.

2000-01-01

Alcohol use among adolescent athletes is fairly high. Young athletes may be more likely to abuse alcohol than their nonathlete peers and to suffer the behavioral and psychosocial consequences of drinking. They are also more prone to binge drinking. Education and prevention strategies should focus on behavioral and psychosocial consequences,…

Short-Term Medical Consequences of the Chernobyl Nuclear Accident: Lessons for the Future

PubMed Central

Gale, Robert Peter

1988-01-01

The author of this article discusses the world's most serious nuclear accident to date: the Chernobyl nuclear accident of April 1986. His major focus is on the short-term medical consequences of the accident, including reduction of exposure to persons at risk, evaluation of persons potentially affected, dosimetry, and specific medical interventions. PMID:21253129

The Macroeconomic Consequences of Renouncing to Universal Access to Antiretroviral Treatment for HIV in Africa: A Micro-Simulation Model

PubMed Central

Ventelou, Bruno; Arrighi, Yves; Greener, Robert; Lamontagne, Erik; Carrieri, Patrizia; Moatti, Jean-Paul

2012-01-01

Aim Previous economic literature on the cost-effectiveness of antiretroviral treatment (ART) programs has been mainly focused on the microeconomic consequences of alternative use of resources devoted to the fight against the HIV pandemic. We rather aim at forecasting the consequences of alternative scenarios for the macroeconomic performance of countries. Methods We used a micro-simulation model based on individuals aged 15–49 selected from nationally representative surveys (DHS for Cameroon, Tanzania and Swaziland) to compare alternative scenarios : 1-freezing of ART programs to current levels of access, 2- universal access (scaling up to 100% coverage by 2015, with two variants defining ART eligibility according to previous or current WHO guidelines). We introduced an “artificial” ageing process by programming methods. Individuals could evolve through different health states: HIV negative, HIV positive (with different stages of the syndrome). Scenarios of ART procurement determine this dynamics. The macroeconomic impact is obtained using sample weights that take into account the resulting age-structure of the population in each scenario and modeling of the consequences on total growth of the economy. Results Increased levels of ART coverage result in decreasing HIV incidence and related mortality. Universal access to ART has a positive impact on workers' productivity; the evaluations performed for Swaziland and Cameroon show that universal access would imply net cost-savings at the scale of the society, when the full macroeconomic consequences are introduced in the calculations. In Tanzania, ART access programs imply a net cost for the economy, but 70% of costs are covered by GDP gains at the 2034 horizon, even in the extended coverage option promoted by WHO guidelines initiating ART at levels of 350 cc/mm3 CD4 cell counts. Conclusion Universal Access ART scaling-up strategies, which are more costly in the short term, remain the best economic choice in the long term. Renouncing or significantly delaying the achievement of this goal, due to “legitimate” short term budgetary constraints would be a misguided choice. PMID:22514619

Healthcare managers in negative media focus: a qualitative study of personification processes and their personal consequences

PubMed Central

2014-01-01

Background Over the last decade healthcare management and managers have increasingly been in focus in public debate. The purpose of the present study was to gain a deeper understanding of how prolonged, unfavorable media focus can influence both the individual as a person and his or her managerial practice in the healthcare organization. Methods In-depth interviews (n = 49) with 24 managers and their superiors, or subordinate human resources/information professionals, and partners were analyzed using a grounded theory approach. Results The conceptual model explains how perceived uncertainties related to the managerial role influence personification and its negative consequences. The role ambiguities comprised challenges regarding the separation of individual identity from the professional function, the interaction with intra-organizational support and political play, and the understanding and acceptance of roles in society. A higher degree of uncertainty in role ambiguity increased both personification and the personal reaction to intense media pressure. Three types of reactions were related to the feeling of being infringed: avoidance and narrow-mindedness; being hard on self, on subordinates, and/or family members; and resignation and dejection. The results are discussed so as to elucidate the importance of support from others within the organization when under media scrutiny. Conclusions The degree of personification seems to determine the personal consequences as well as the consequences for their managerial practice. Organizational support for managers appearing in the media would probably be beneficial for both the manager and the organization. PMID:24397306

The effects of social and health consequence framing on heavy drinking intentions among college students.

PubMed

Kingsbury, John H; Gibbons, Frederick X; Gerrard, Meg

2015-02-01

Many interventions targeting college student drinking have focused on negative health effects of drinking heavily; however, some research suggests that social factors may have a stronger influence on the drinking behaviour of young people. Moreover, few studies have examined message framing effects in the context of alcohol consumption. This study investigated the effects of social and health consequence framing on college students' intentions to engage in heavy drinking. This study used a 2 × 2 experimental design with an appended control condition. One hundred and twenty-four college students (74 women; M(age) = 18.9) participated in this study for course credit. Participants read vignettes that were ostensibly written by a recent graduate from the university, who described an episode of drinking in which he or she experienced either social or health consequences. These consequences were framed as either a gain (i.e., positive consequences of not drinking heavily) or a loss (i.e., negative consequences of drinking heavily). After reading the vignette, participants completed a measure of heavy drinking intentions. Regression analyses revealed that social consequences were associated with lower heavy drinking intentions when framed as a loss and that health consequences were associated with lower heavy drinking intentions when framed as a gain. These effects were stronger among those who reported higher (vs. lower) levels of previous drinking. Results suggest that interventions that focus on the negative health effects of heavy drinking may be improved by instead emphasizing the negative social consequences of drinking heavily and the positive health consequences of avoiding this behaviour. Statement of contribution What is already known on this subject? Previous studies have shown that gain frames are more effective than loss frames when highlighting the health consequences of health risk behaviours, such as heavy drinking. The heavy drinking behaviour of young people is influenced by social factors (e.g., perceived social consequences). However, little is known about framing effects for social consequences of heavy drinking. What does this study add? This study builds on previous research by demonstrating that a loss frame is more effective than a gain frame when highlighting the social consequences of health risk behaviour. Framing effects are strongest for those with more previous drinking experience. © 2014 The British Psychological Society.

The role of personal values in Chinese consumers' food consumption decisions. A case study of healthy drinks.

PubMed

Lee, Pui Yee; Lusk, Karen; Mirosa, Miranda; Oey, Indrawati

2014-02-01

Differences in culture, language, and behavior between Chinese and Western consumers make entering the Chinese market a challenge. Chinese consumers may desire similar product features (e.g. brand name, quality, and flavor) to Western consumers but the value that consumers attach to the same product may differ cross-nationally. Besides values, an understanding of desired product attributes and the consequences linking to these values is also important. To the authors' knowledge, there is no published scientific research that investigates how personal values influence Chinese consumers' food consumption decisions. The aim of this research was to identify the links among product attributes, consequences of these attributes, and personal values associated with healthy drink consumption decisions within the Chinese market. Specifically, this research employed means-end chain theory and used association pattern technique (APT) as the main data collection technique to identify these links. Focus groups (n=6) were held in Hangzhou, China to identify the important attributes and consequences involved in the consumption decisions of healthy drinks. These attributes and consequences along with Schwartz's 10 basic values were used to construct the matrices included in the APT survey. A total of 600 APT surveys were administered in six different companies in Hangzhou, with 570 returned. Construction of the hierarchical value map (HVM) identified four of Schwartz's personal values influencing Chinese consumers' healthy drink consumption decisions: security, hedonism, benevolence, and self-direction. Food safety was the foremost concern for Chinese consumers when choosing healthy drinks. Chinese consumers also sought a good tasting and nutritious drink that was good value for money. Results from this study provide food marketers with an in-depth understanding of Chinese consumers' healthy drink consumption decisions. Implications and recommendations are provided that will assist food marketers to effectively enact marketing strategies in China. Copyright © 2013 Elsevier Ltd. All rights reserved.

Racial/Ethnic Disparities in Alcohol-related Problems: Differences by Gender and Level of Heavy Drinking

PubMed Central

Witbrodt, Jane; Mulia, Nina; Zemore, Sarah E.; Kerr, William C.

2014-01-01

Objective While prior studies have reported racial/ethnic disparities in alcohol-related problems at a given level of heavy drinking, particularly lower levels, it is unclear whether these occur in both genders and are an artifact of racial/ethnic differences in drink alcohol content. Such information is important to understanding disparities and developing specific, targeted interventions. This study addresses these questions and examines disparities in specific types of alcohol problems across racial-gender groups. Method Using 2005 and 2010 National Alcohol Survey data (N=7,249 current drinkers), gender-stratified regression analyses were conducted to assess black-white and Hispanic-white disparities in alcohol dependence and negative drinking consequences at equivalent levels of heavy drinking. Heavy drinking was measured using a gender-specific, composite drinking-patterns variable derived through factor analysis. Analyses were replicated using adjusted-alcohol consumption variables that account for group differences in drink alcohol content based on race/ethnicity, gender, age and alcoholic beverage. Results Compared to white men, black and Hispanic men had higher rates of injuries/accidents/health and social consequences, and marginally greater work/legal consequences (p< .10). Hispanic women had marginally higher rates of social consequences. In main effects models controlling for demographics, light drinking and heavy drinking, only black women and men had greater odds of alcohol-related problems relative to whites. Interaction models indicated that compared to whites, black women had greater odds of dependence at all levels of heavy drinking, while both black and Hispanic men had elevated risk of alcohol problems only at lower levels of heavy drinking. Drink alcohol content adjustments did not significantly alter findings for either gender. Conclusions This study highlights the gender-specific nature of racial/ethnic disparities. Interventions focused on reducing heavy drinking might not address disparities in alcohol-related problems that exist at low levels of heavy drinking. Future research should consider the potential role of environmental and genetic factors in these disparities. PMID:24730475

ANTECEDENT VERSUS CONSEQUENT EVENTS AS PREDICTORS OF PROBLEM BEHAVIOR

PubMed Central

Camp, Erin M; Iwata, Brian A; Hammond, Jennifer L; Bloom, Sarah E

2009-01-01

Comparisons of results from descriptive and functional analyses of problem behavior generally have shown poor correspondence. Most descriptive analyses have focused on relations between consequent events and behavior, and it has been noted that attention is a common consequence for problem behavior even though it may not be a functional reinforcer. Because attention may be prescribed simply as a means of stopping serious problem behavior, it is possible that naturally occurring antecedent events (establishing operations) might be better predictors of problem behavior than consequences. We conducted descriptive and functional analyses of the problem behaviors of 7 participants. Conditional probabilities based on combined antecedent and consequent events showed correspondence with the functional analysis data for 4 of the 7 participants, but antecedent events were no better than consequent events in identifying the function of problem behavior. PMID:19949538

Assessing the consequences of unrealistic optimism: Challenges and recommendations.

PubMed

Shepperd, James A; Pogge, Gabrielle; Howell, Jennifer L

2017-04-01

Of the hundreds of studies published on unrealistic optimism (i.e., expecting a better personal future than is reasonably likely), most have focused on demonstrating the phenomenon, examining boundary conditions, or documenting causes. Few studies have examined the consequences of unrealistic optimism. In this article, we provide an overview of the measurement of unrealistic optimism, review possible consequences, and identify numerous challenges confronting investigators attempting to understand the consequences. Assessing the consequences of unrealistic optimism is tricky, and ultimately probably impossible when researchers assess unrealistic optimism at the group level (which reveals if a group of people is displaying unrealistic optimism on average) rather than the individual level (which reveals whether a specific individual displays unrealistic optimism). We offer recommendations to researchers who wish to examine the consequences of unrealistic optimism. Copyright © 2016 Elsevier Inc. All rights reserved.

Public-on-private dual practice among physicians in public hospitals of Tigray National Regional State, North Ethiopia: perspectives of physicians, patients and managers.

PubMed

Abera, Goitom Gigar; Alemayehu, Yibeltal Kiflie; Herrin, Jeph

2017-11-10

Physicians who work in the private sector while also holding a salaried job in a public hospital, known as "dual practice," is one of the main retention strategies adopted by the government of Ethiopia. Dual practice was legally endorsed in Tigray National Regional State, Ethiopia in 2010. Therefore, the aim of this study was to explore the extent of dual practice, reasons why physicians engage in it, and its effects on public hospital services in this state in northern Ethiopia. A cross-sectional study using mixed methods was conducted from February to March 2011 in six geographically representative public hospitals of Tigray National Regional State. A semi-structured, self-administered questionnaire was distributed to all physicians working in the study hospitals, and an interviewer-administered, structured questionnaire was used to collect data from admitted patients. Focus group discussions were conducted with hospital governing boards. Quantitative and qualitative data were used in the analysis. Data were collected from 31 physicians and 449 patients in the six study hospitals. Six focus group discussions were conducted. Twenty-eight (90.3%) of the physicians were engaged in dual practice to some extent: 16 (51.6%) owned private clinics outside the public hospital, 5 (16.1%) worked part-time in outside private clinics, and 7 (22.6%) worked in the private wing of public hospitals. Income supplementation was the primary reason for engaging in dual practice, as reported by 100% of the physicians. The positive effects of dual practice from both managers' and physicians' perspectives were physician retention in the public sector. Ninety-one patients (20.3%) had been referred from a private clinic immediately prior to their current admission-a circular diversion pattern. Eighteen (19.8%) of the diverted patients reported that health workers in the public hospitals diverted them. Circular diversion pattern of referral system is the key negative consequence of dual practice. Physicians and hospital managers agreed that health worker retention was the main positive consequence of dual practice upon the public sector, and banning dual practice would result in a major loss of senior physicians. The motive behind the circular diversion pattern described by patients should be studied further.

Long-period amplification in deep alluvial basins and consequences for site-specific probabilistic seismic-hazard: the case of Castelleone in the Po Plain (Northern Italy)

NASA Astrophysics Data System (ADS)

Barani, S.; Mascandola, C.; Massa, M.; Spallarossa, D.

2017-12-01

The recent Emilia seismic sequence (Northern Italy) occurred at the end of the first half of 2012 with main shock of Mw6.1 highlighted the importance of studying site effects in the Po Plain, the larger and deeper sedimentary basin in Italy. As has long been known, long-period amplification related to deep sedimentary basins can significantly affect the characteristics of the ground-motion induced by strong earthquakes. It follows that the effects of deep sedimentary deposits on ground shaking require special attention during the definition of the design seismic action. The work presented here analyzes the impact of deep-soil discontinuities on ground-motion amplification, with particular focus on long-period probabilistic seismic-hazard assessment. The study focuses on the site of Castelleone, where a seismic station of the Italian National Seismic Network has been recording since 2009. Our study includes both experimental and numerical site response analyses. Specifically, extensive active and passive geophysical measurements were carried out in order to define a detailed shear-wave velocity (VS) model to be used in the numerical analyses. These latter are needed to assess the site-specific ground-motion hazard. Besides classical seismic refraction profiles and multichannel analysis of surface waves, we analyzed ambient vibration measurements in both single and array configurations. The VS profile was determined via joint inversion of the experimental phase-velocity dispersion curve with the ellipticity curve derived from horizontal-to-vertical spectral ratios. The profile shows two main discontinuities at depths of around 160 and 1350 m, respectively. The probabilistic site-specific hazard was assessed in terms of both spectral acceleration and displacement. A partially non-ergodic approach was adopted. We have found that the spectral acceleration hazard is barely sensitive to long-period (up to 10 s) amplification related to the deeper discontinuity whereas the displacement hazard is strongly affected. Our results show that neglecting the effects of the deeper discontinuity implies an underestimation of the hazard of up to about 49% for a mean return period (MRP) of 475 years and 57% for an MRP of 2475 years, with possible consequences on the design of very tall buildings and large bridges.

College Psychiatry 2006: Challenges and Opportunities

ERIC Educational Resources Information Center

Kadison, Richard

2006-01-01

This article discusses some of the dramatic changes seen in college mental health issues over the past 2 decades. These modifications are a consequence of many factors: changes in our health care system (managed care), new effective biological treatments (medications), the focus of psychiatric training (biologic focus), technology advances…

Improve Relationships to Improve Student Performance

ERIC Educational Resources Information Center

Arum, Richard

2011-01-01

Attempts to raise student performance have focused primarily on either relationships between adults in the system or formal curriculum. Relatively ignored has been a focus on what sociologists believe is the primary relationship of consequence for student outcomes--authority relationships between students and educators. Successful school reform is…

Mental illness stigma: concepts, consequences, and initiatives to reduce stigma.

PubMed

Rüsch, Nicolas; Angermeyer, Matthias C; Corrigan, Patrick W

2005-12-01

Persons with mental illness frequently encounter public stigma and may suffer from self-stigma. This review aims to clarify the concept of mental illness stigma and discuss consequences for individuals with mental illness. After a conceptual overview of stigma we discuss two leading concepts of mental illness stigma and consequences of stigma, focussing on self-stigma/empowerment and fear of stigma as a barrier to using health services. Finally, we discuss three main strategies to reduce stigma -- protest, education, and contact -- and give examples of current anti-stigma campaigns. Well-designed anti-stigma initiatives will help to diminish negative consequences of mental illness stigma.

Soil Warming: Consequences for Foliar Litter Decay in a Spruce-Fir Forest in Maine, USA

Treesearch

Lindsey E. Rustad; Ivan J. Fernandez

1998-01-01

Increased rates of litter decay due to projected global warming could substantially alter the balance between C assimilation and release in forest soils, with consequent feedbacks to climate change. This study was conducted to investigate the effects of soil warming on the decomposition of red spruce (Picea rubens Sarg.) and red maple (...

The role of pancreatic leakage on rising of postoperative complications following pancreatic surgery.

PubMed

Benzoni, Enrico; Saccomano, Enrico; Zompicchiatti, Aron; Lorenzin, Dario; Baccarani, Umberto; Adani, Gian Luigi; Uzzau, Alessandro; Noce, Luigi; Cedolini, Carla; Bresadola, Fabrizio; De Anna, Dino; Intini, Sergio

2008-10-01

The variations in methods of pancreatic stump management and the volume of literature available on both main pancreatic duct and pancreaticoenetric anastomosis leak indicates the concern associated with the leak and the continuing efforts to prevent it. Herein we analyzed the role of pancreatic leakage followed by pancreatic surgery on the incidence of postoperative morbidity. From 1989 to 2005, we performed 76 pancreaticoduodenectomy (PD) and 26 distal pancreatectomy (DP), assumed as control case). During DP the parenchymal transection was performed with a linear stapler. The surgical reconstruction after PD was as follows: 11 manual nonabsorbable stitch closure of the main duct, 24 closure of the main duct with linear stapler, 17 temporary occlusion of the main duct with neoprene glue, and 24 duct-to-mucosa anastomosis. In the PD group, morbidity rate was 60%, caused by pancreatic leakage, with an incidence of 48%, hemorrhagic complication, occurred in 10% of patients following surgical procedure and infectious complication, with an incidence of 15%. After distal pancreatectomy we recorded 80, 7% no complications, 3, 9% leakage, 15, 4% hemoperitoneum. By multivariate analysis bleeding complications, biliary anastomosis leakage, and infectious complications were consequences of pancreatic leakage (P = 0.025, P = 0.025, and P = 0.025, respectively). A significant statistical difference was recorded analyzing re-operation rates between closure of the main duct with linear stapler versus temporary occlusion of the main duct with neoprene glue (t = 0.049) and closure of the main duct with linear stapler versus duct-to-mucosa anastomosis (t = 0.003). On the ground of our results of bleeding complication, biliary anastomosis leakage and infectious complication were consequences of pancreatic leakage: failure of a surgical anastomosis has serious consequences, particularly in case of anastomosis of the pancreas to the small bowel, because of the digestive capacities of activated pancreatic secretions.

Individual and Class Norms Differentially Predict Proactive and Reactive Aggression: A Functional Analysis

ERIC Educational Resources Information Center

Frey, Karin S.; Higheagle Strong, Zoe; Onyewuenyi, Adaurennaya C.

2017-01-01

Theory and research using a social-information processing framework indicate that reward-focused (proactive) aggression has different social consequences than defense-focused (reactive) aggression. Students use norms that identify expected and socially approved behaviors as guides to their own actions. Differences in social-cognitive processing…

Efficacy of Two Different Instructional Methods Involving Complex Ecological Content

ERIC Educational Resources Information Center

Randler, Christoph; Bogner, Franz X.

2009-01-01

Teaching and learning approaches in ecology very often follow linear conceptions of ecosystems. Empirical studies with an ecological focus consistent with existing syllabi and focusing on cognitive achievement are scarce. Consequently, we concentrated on a classroom unit that offers learning materials and highlights the existing complexity rather…

Classroom Talk: Co-Constructing a "Difficult Student"

ERIC Educational Resources Information Center

Graff, Nelson

2009-01-01

Background: Research on teacher-student relationships has focused logically on classroom talk. Investigations of classroom talk range from broad consideration of the structures of such talk to a somewhat narrower focus on the interpersonal dimensions of such talk, and their consequences for student achievement and motivation. Purpose: This study…

Applying Art and Action

ERIC Educational Resources Information Center

Viglione, Nick M.

2009-01-01

The education system in the United States is going through change. Consequently, curriculum and instructional delivery are focusing on math, reading, and science. This focus is causing an effect that reduces the amount of arts becoming infused into the school design. An alternative education program in a charter school has created a…

Consequences of Law and Rule Breaking (Law-Related Education Materials) 1982-83. Materials Produced by Teachers in Highlands County.

ERIC Educational Resources Information Center

Allen, Rodney F., Ed.

Approximately 40 teacher-developed activities for legal education in some Florida elementary and junior high schools focus on the consequences of breaking rules and committing crimes and on victims of crime (individuals, community, society). Most of the lessons present a brief, one-page reading followed by questions to determine students'…

Alignment as a Consequence of Expectation Adaptation: Syntactic Priming Is Affected by the Prime's Prediction Error Given both Prior and Recent Experience

ERIC Educational Resources Information Center

Jaeger, T. Florian; Snider, Neal E.

2013-01-01

Speakers show a remarkable tendency to align their productions with their interlocutors'. Focusing on sentence production, we investigate the cognitive systems underlying such alignment (syntactic priming). Our guiding hypothesis is that syntactic priming is a consequence of a language processing system that is organized to achieve efficient…

Consequences of Law and Rule Breaking (Law Related Education Materials) 1982-83. Materials Produced by Teachers in Hardee County.

ERIC Educational Resources Information Center

Allen, Rodney F., Ed.

Approximately 60 teacher-developed activities for legal education in some Florida elementary and junior high schools focus on the consequences of breaking rules and committing crimes and on victims of crime (individuals, community, society). Most of the lessons present a brief, one-page reading followed by questions to determine students'…

Measuring Government Effectiveness and Its Consequences for Social Welfare in Sub-Saharan African Countries

ERIC Educational Resources Information Center

Sacks, Audrey; Levi, Margaret

2010-01-01

We introduce a method for measuring effective government and modeling its consequences for social welfare at the individual level. Our focus is on the experiences of citizens living in African countries where famine remains a serious threat. If a government is effective, it will be able to deliver goods that individuals need to improve their…

Antecedents and Consequences of Service Quality in a Higher Education Context: A Qualitative Research Approach

ERIC Educational Resources Information Center

Sultan, Parves; Wong, Ho Yin

2013-01-01

Purpose: The purpose of the paper is to report on the perception of students in regard to critical antecedents, dimensions and consequences of service quality with an aim to develop a theoretical model in the context of a university in Australia. Design/methodology/approach: This research used focus group discussions with 19 students who had been…

Consequences of musculoskeletal disorders on occupational events: a life-long perspective from a national survey.

PubMed

Leclerc, Annette; Pascal, Pauline; Chastang, Jean-François; Descatha, Alexis

2014-06-01

Musculoskeletal disorders (MSDs) are among the most frequent causes of disability, with potentially important consequences. Our objective was to investigate from a lifelong perspective the factors associated with these consequences, including permanent withdrawal from the workforce, focusing especially on factors at the start of working life. The data come from the SIP national survey (Santé et Histoire Professionnelle, health and occupational history). Three groups of subjects were compared with multinomial logistic models: group 1 (G1), who had MSDs that caused an important event in their working life; group 2, who had MSDs without any such consequence; and group 3 (G3), who had no MSD. In multivariate models, MSDs with consequences on occupational events were strongly associated with a low educational level for both sexes, and with some working conditions. In the comparison G1/G3, the odds-ratio (OR) for "no diploma" compared to "university level" was 4.41 and the confidence interval (95 % CI) 2.31-8.40 for men. For women the OR was 2.02 (95 % CI 1.32, 3.10). Group 2's educational level was between G1 and G3, closer to G3. For men, another risk factor was a first job in construction or farming (OR = 2.95 for construction, 2.23 for farming, comparison G1/G3). Comparisons focusing on "permanent withdrawal from the workforce" yielded similar results. Associations between occupational history and health are complex; the results strongly suggest that factors at the beginning of working life, including level of education, have important delayed consequences, especially for workers with health disorders such as MDSs. In order to reduce the frequency of negative consequences, a better knowledge on causal mechanisms would be needed.

Experiences of general practices with a participatory pay-for-performance program: a qualitative study in primary care.

PubMed

Kirschner, Kirsten; Braspenning, Jozé; Jacobs, J E Annelies; Grol, Richard

2013-01-01

The involvement of target users in the design choices of a pay-for-performance program may enhance its impact, but little is known about the views of participants in these programs. To explore general practices' experiences with pay-for-performance in primary care we conducted a qualitative study in general practices in the Netherlands. Thirty out of 65 general practices participating in a pay-for-performance program, stratified for bonus, were invited for a semistructured interview on feasibility, feedback and the bonus, spending of the bonus, unintended consequences, and future developments. Content analysis was used to process the resulting transcripts. We included 29 practices. The feasibility of the pay-for-performance program was questioned due to the substantial time investment. The feedback on clinical care, practice management and patient experience was mostly discussed in the team, and used for improvement plans, but was also qualified as annoying for one GP and for another GP it brought feelings of insecurity. Most practices considered the bonus a stimulus to improve quality of care, in addition to compensation for their effort and time invested. Distinctive performance features were not displayed, for instance, on a website. The bonus was mainly spent on new equipment or team building. Practices referred to gaming and focusing on those aspects that were incentivised ('tunnel vision') as unintended consequences. Future developments should be directed to absolute thresholds, new indicators to keep the process going, and an independent audit. Linking a part of the bonus to innovation was also suggested. The participants thought the pay-for-performance program was a labour-intensive positive breakthrough to stimulate quality improvement, but warned of unintended consequences of the program and the sustainability of the indicator set.

Behavioural and Cognitive Psychotherapy: A Descriptive Review (2000 to July 2016).

PubMed

Caro Gabalda, Isabel

2017-07-01

The Behavioural and Cognitive Psychotherapy (BCP) Journal is the main academic publication of the British Association for Behavioural and Cognitive Psychotherapies. It publishes empirical studies, reviews and theoretical papers, brief reports and single cases. To describe the main areas of interest and focus in BCP papers. All the papers published in BCP from 2000 to July 2016 were analysed. A categorization procedure was followed with 813 contributions in six main areas: main author country; main author gender; kind of contribution; kind of therapeutic approaches; kind of samples; kind of focus/topic. Although the journal's scope is international, first authors tend to come from English-speaking countries. Since 2009, females contribute more than males. Empirical studies surpass theoretical studies and reviews, while the main therapy denomination is cognitive behavioural therapy. Variability of samples is wide, and ranges from analogues to main disorders. Finally, the main focus of papers is to study change and psychopathology, therapists' training and improvement of CBT. Given the total number of categorized papers, it can be tentatively assumed that they could exemplify some main areas of interest and evolvement in the cognitive and behavioural field.

Main, Mediating, and Moderating Effects of Social Support on the Well-Being of Survivors of Intimate Partner Violence across 2 Years

ERIC Educational Resources Information Center

Beeble, Marisa L.; Bybee, Deborah; Sullivan, Cris M.; Adams, Adrienne E.

2009-01-01

Intimate partner violence is a serious and pervasive social problem with deleterious consequences for survivors' well-being. The current study involved interviewing 160 survivors 6 times over 2 years to examine the role of social support in explaining or buffering these negative psychological consequences. The authors examined both between- and…

Consequences of non-random species loss for decomposition dynamics: Experimental evidence for additive and non-additive effects

Treesearch

Becky A. Ball; Mark D. Hunter; John S. Kominoski; Christopher M. Swan; Mark A. Bradford

2008-01-01

Although litter decomposition is a fundamental ecological process, most of our understanding comes from studies of single-species decay. Recently, litter-mixing studies have tested whether monoculture data can be applied to mixed-litter systems. These studies have mainly attempted to detect non-additive effects of litter mixing, which address potential consequences of...

Prevention and treatment of low back pain: evidence, challenges, and promising directions.

PubMed

Foster, Nadine E; Anema, Johannes R; Cherkin, Dan; Chou, Roger; Cohen, Steven P; Gross, Douglas P; Ferreira, Paulo H; Fritz, Julie M; Koes, Bart W; Peul, Wilco; Turner, Judith A; Maher, Chris G

2018-06-09

Many clinical practice guidelines recommend similar approaches for the assessment and management of low back pain. Recommendations include use of a biopsychosocial framework to guide management with initial non-pharmacological treatment, including education that supports self-management and resumption of normal activities and exercise, and psychological programmes for those with persistent symptoms. Guidelines recommend prudent use of medication, imaging, and surgery. The recommendations are based on trials almost exclusively from high-income countries, focused mainly on treatments rather than on prevention, with limited data for cost-effectiveness. However, globally, gaps between evidence and practice exist, with limited use of recommended first-line treatments and inappropriately high use of imaging, rest, opioids, spinal injections, and surgery. Doing more of the same will not reduce back-related disability or its long-term consequences. The advances with the greatest potential are arguably those that align practice with the evidence, reduce the focus on spinal abnormalities, and ensure promotion of activity and function, including work participation. We have identified effective, promising, or emerging solutions that could offer new directions, but that need greater attention and further research to determine if they are appropriate for large-scale implementation. These potential solutions include focused strategies to implement best practice, the redesign of clinical pathways, integrated health and occupational interventions to reduce work disability, changes in compensation and disability claims policies, and public health and prevention strategies. Copyright © 2018 Elsevier Ltd. All rights reserved.

An Initiative for the Study and Use of Genetic Diversity of Domesticated Plants and Their Wild Relatives.

PubMed

Mastretta-Yanes, Alicia; Acevedo Gasman, Francisca; Burgeff, Caroline; Cano Ramírez, Margarita; Piñero, Daniel; Sarukhán, José

2018-01-01

Domestication has been influenced by formal plant breeding since the onset of intensive agriculture and the Green Revolution. Despite providing food security for some regions, intensive agriculture has had substantial detrimental consequences for the environment and does not fulfill smallholder's needs under most developing countries conditions. Therefore, it is necessary to look for alternative plant production techniques, effective for each environmental, socio-cultural, and economic conditions. This is particularly relevant for countries that are megadiverse and major centers of plant domestication and diversification. In this white paper, a Mexico-centered initiative is proposed, with two main objectives: (1) to study, understand, conserve, and sustainably use the genetic diversity of domesticated plants and their wild relatives, as well as the ongoing evolutionary processes that generate and maintain it; and (2) to strengthen food and forestry production in a socially fair and environmentally friendly way. To fulfill these objectives, the initiative focuses on the source of variability available for domestication ( genetic diversity and functional genomics ), the context in which domestication acts ( breeding and production ) and one of its main challenges ( environmental change ). Research on these components can be framed to target and connect both the theoretical understanding of the evolutionary processes, the practical aspects of conservation, and food and forestry production. The target, main challenges, problems to be faced and key research questions are presented for each component, followed by a roadmap for the consolidation of this proposal as a national initiative.

Impacts of El Niño-Southern Oscillation on the wheat market: A global dynamic analysis

PubMed Central

2017-01-01

Although the widespread influence of the El Niño-Southern Oscillation (ENSO) occurrences on crop yields of the main agricultural commodities is well known, the global socio-economic consequences of ENSO still remain uncertain. Given the global importance of wheat for global consumption by providing 20% of global calories and nourishment, the monitoring and prediction of ENSO-induced variations in the worldwide wheat market are essential for allowing national governments to manage the associated risks and to ensure the supplies of wheat for consumers, including the underprivileged. To this end, we propose a global dynamic model for the analysis of ENSO impacts on wheat yield anomalies, export prices, exports and stock-to-use ratios. Our framework focuses on seven countries/regions: the six main wheat-exporting countries—the United States, Argentina, Australia, Canada, the EU, and the group of the main Black Sea export countries, i.e. Russia, Ukraine, and Kazakhstan—plus the rest of the world. The study shows that La Niña exerts, on average, a stronger and negative impact on wheat yield anomalies, exports and stock-to-use ratios than El Niño. In contrast, wheat export prices are positively related to La Niña occurrences evidencing, once again, its steady impact in both the short and long run. Our findings emphasize the importance of the two ENSO extreme phases for the worldwide wheat market. PMID:28594886

Micro-Raman spectroscopy on oral tissues

NASA Astrophysics Data System (ADS)

Zenone, F.; Lepore, M.; Perna, G.; Carmone, P.; Riccio, R.; Gaeta, G. M.; Capozzi, V.

2006-02-01

Micro-Raman Spectroscopy (μ-RS) provides a unique tool in medicine for a not invasive and real time analysis of biological tissue for biopsy and "in vivo" investigation. Based on the evaluation of molecular vibration frequencies, the μ-RS is able to detect the main molecular bonds of protein constituents, as the C-H and C-C ones. Changes in frequency or in the relative intensity of the vibration modes revealed by μ-RS can be related to changes of chemical bond and of protein structure induced by pathology. The μ-RS has been performed on samples of oral tissue from informed patients, affected by pemphigus vulgaris (an oral pathology) in an advanced regression state. The biopsies were thin slices (about 1mm thick) with 6mm diameter. The sample was measured through a 170 μm thick cover-glass. The experimental set-up was mainly composed by a He-Ne laser and a monochromator equipped with a Peltier cell and with a grating of 1800 grooves/mm. The laser light was focused on the sample surface by means of a long focal length 50X optical objective. The main protein bonds are clearly detectable in the considered samples and this give important information on the integrity and on the state of tissue components (lipids and proteins), and consequently on the occurrence of pathology. The potential application of this method for in vivo analysis is an invaluable alternative to biopsy and pathological examinations for many medical application as screening diagnostic, therapy progress examination, and surgical support.

Challenges of metabolomics in human gut microbiota research.

PubMed

Smirnov, Kirill S; Maier, Tanja V; Walker, Alesia; Heinzmann, Silke S; Forcisi, Sara; Martinez, Inés; Walter, Jens; Schmitt-Kopplin, Philippe

2016-08-01

The review highlights the role of metabolomics in studying human gut microbial metabolism. Microbial communities in our gut exert a multitude of functions with huge impact on human health and disease. Within the meta-omics discipline, gut microbiome is studied by (meta)genomics, (meta)transcriptomics, (meta)proteomics and metabolomics. The goal of metabolomics research applied to fecal samples is to perform their metabolic profiling, to quantify compounds and classes of interest, to characterize small molecules produced by gut microbes. Nuclear magnetic resonance spectroscopy and mass spectrometry are main technologies that are applied in fecal metabolomics. Metabolomics studies have been increasingly used in gut microbiota related research regarding health and disease with main focus on understanding inflammatory bowel diseases. The elucidated metabolites in this field are summarized in this review. We also addressed the main challenges of metabolomics in current and future gut microbiota research. The first challenge reflects the need of adequate analytical tools and pipelines, including sample handling, selection of appropriate equipment, and statistical evaluation to enable meaningful biological interpretation. The second challenge is related to the choice of the right animal model for studies on gut microbiota. We exemplified this using NMR spectroscopy for the investigation of cross-species comparison of fecal metabolite profiles. Finally, we present the problem of variability of human gut microbiota and metabolome that has important consequences on the concepts of personalized nutrition and medicine. Copyright © 2016 Elsevier GmbH. All rights reserved.

Clinical consequences of toxic envenomations by Hymenoptera.

PubMed

Schmidt, Justin O

2018-05-19

Many familiar Hymenoptera are brightly colored and can sting painfully-thus, their threat and clinical importance may be exaggerated. Most stinging insects only sting to defend themselves or their colonies from predators. The clinical nature of Hymenoptera envenomations contrasts that of other venomous animals, including other arthropods, primarily because allergic reaction, not direct intoxication, is the usual main concern. This review focuses mainly on the clinical features of direct toxicity to Hymenoptera envenomations, which can induce a high incidence of acute renal failure, liver failure, multiple organ failures, and death. Toxic mass envenomations by honeybees usually entail many hundreds or more stings per victim. In contrast to honeybee toxic envenomations, hornet sting envenomations can be clinically threatening with only 20-200 stings needed to cause kidney and other organ failures. Many lethal envenomations by honeybees occur in rural areas in the New World and Africa and are not recorded or documented. In contrast, deaths by hornets occur mainly to Asia. The most frequent and important envenomating taxa are honeybees, hornets, yellowjacket wasps, paper wasps, fire ants, and jack jumper ants. Occasional envenomating taxa include bumblebees, bullet ants, harvester ants, solitary wasps, solitary bees, and various ants of lesser clinical importance. Envenomations by Hymenoptera usually can be avoided if one considers that bees, wasps and ants "view" us as potential threats or predators, and that with information about the biology of stinging Hymenoptera, humans can minimize adverse incidents. Copyright © 2018 Elsevier Ltd. All rights reserved.

An Initiative for the Study and Use of Genetic Diversity of Domesticated Plants and Their Wild Relatives

PubMed Central

Mastretta-Yanes, Alicia; Acevedo Gasman, Francisca; Burgeff, Caroline; Cano Ramírez, Margarita; Piñero, Daniel; Sarukhán, José

2018-01-01

Domestication has been influenced by formal plant breeding since the onset of intensive agriculture and the Green Revolution. Despite providing food security for some regions, intensive agriculture has had substantial detrimental consequences for the environment and does not fulfill smallholder’s needs under most developing countries conditions. Therefore, it is necessary to look for alternative plant production techniques, effective for each environmental, socio-cultural, and economic conditions. This is particularly relevant for countries that are megadiverse and major centers of plant domestication and diversification. In this white paper, a Mexico-centered initiative is proposed, with two main objectives: (1) to study, understand, conserve, and sustainably use the genetic diversity of domesticated plants and their wild relatives, as well as the ongoing evolutionary processes that generate and maintain it; and (2) to strengthen food and forestry production in a socially fair and environmentally friendly way. To fulfill these objectives, the initiative focuses on the source of variability available for domestication (genetic diversity and functional genomics), the context in which domestication acts (breeding and production) and one of its main challenges (environmental change). Research on these components can be framed to target and connect both the theoretical understanding of the evolutionary processes, the practical aspects of conservation, and food and forestry production. The target, main challenges, problems to be faced and key research questions are presented for each component, followed by a roadmap for the consolidation of this proposal as a national initiative. PMID:29515612

Temporal accommodation response measured by photorefractive accommodation measurement device

NASA Astrophysics Data System (ADS)

Song, Byoungsub; Leportier, Thibault; Park, Min-Chul

2017-02-01

Although accommodation response plays an important role in the human vision system for perception of distance, some three-dimensional (3D) displays offer depth stimuli regardless of the accommodation response. The consequence is that most observers watching 3D displays have complained about visual fatigue. The measurement of the accommodation response is therefore necessary to develop human-friendly 3D displays. However, only few studies about accommodation measurement have been reported. Most of the investigations have been focused on the measurement and analysis of monocular accommodation responses only because the accommodation response works individually in each eye. Moreover, a main eye perceives dominantly the object distance. However, the binocular accommodation response should be examined because both eyes are used to watch the 3D display in natural conditions. The ophthalmic instrument that we developed enabled to measure changes in the accommodation response of the two eyes simultaneously. Two cameras acquired separately the infrared images reflected from each eyes after the reflected beams passed through a cylindrical lens. The changes in the accommodation response could then be estimated from the changes in the astigmatism ratio of the infrared images that were acquired in real time. In this paper, we compared the accommodation responses of main eye between the monocular and the binocular conditions. The two eyes were measured one by one, with only one eye opened, during measurement for monocular condition. Then the two eyes were examined simultaneously for binocular condition. The results showed similar tendencies for main eye accommodation response in both cases.

Impacts of El Niño-Southern Oscillation on the wheat market: A global dynamic analysis.

PubMed

Gutierrez, Luciano

2017-01-01

Although the widespread influence of the El Niño-Southern Oscillation (ENSO) occurrences on crop yields of the main agricultural commodities is well known, the global socio-economic consequences of ENSO still remain uncertain. Given the global importance of wheat for global consumption by providing 20% of global calories and nourishment, the monitoring and prediction of ENSO-induced variations in the worldwide wheat market are essential for allowing national governments to manage the associated risks and to ensure the supplies of wheat for consumers, including the underprivileged. To this end, we propose a global dynamic model for the analysis of ENSO impacts on wheat yield anomalies, export prices, exports and stock-to-use ratios. Our framework focuses on seven countries/regions: the six main wheat-exporting countries-the United States, Argentina, Australia, Canada, the EU, and the group of the main Black Sea export countries, i.e. Russia, Ukraine, and Kazakhstan-plus the rest of the world. The study shows that La Niña exerts, on average, a stronger and negative impact on wheat yield anomalies, exports and stock-to-use ratios than El Niño. In contrast, wheat export prices are positively related to La Niña occurrences evidencing, once again, its steady impact in both the short and long run. Our findings emphasize the importance of the two ENSO extreme phases for the worldwide wheat market.

Comparison of Personal, Social and Academic Variables Related to University Drop-out and Persistence.

PubMed

Bernardo, Ana; Esteban, María; Fernández, Estrella; Cervero, Antonio; Tuero, Ellián; Solano, Paula

2016-01-01

Dropping out of university has serious consequences not only for the student who drops out but also for the institution and society as a whole. Although this phenomenon has been widely studied, there is a need for broader knowledge of the context in which it occurs. Yet research on the subject often focuses on variables that, although they affect drop-out rates, lie beyond a university's control. This makes it hard to come up with effective preventive measures. That is why a northern Spanish university has undertaken a ex post facto holistic research study on 1,311 freshmen (2008/9, 2009/10, and 2010/11 cohorts). The study falls within the framework of the ALFA-GUIA European Project and focuses on those drop-out factors where there is scope for taking remedial measures. This research explored the possible relationship of degree drop-out and different categories of variables: variables related to the educational stage prior to university entry (path to entry university and main reason for degree choice), variables related to integration and coexistence at university (social integration, academic integration, relationships with teachers/peers and value of the living environment) financial status and performance during university studies (in terms of compliance with the program, time devoted to study, use of study techniques and class attendance). Descriptive, correlational and variance analyses were conducted to discover which of these variables really distinguish those students who drop-out from their peers who complete their studies. Results highlight the influence of vocation as main reason for degree choice, path to university entry, financial independency, social and academic adaptation, time devoted to study, use of study techniques and program compliance in the studied phenomenon.

Comparison of Personal, Social and Academic Variables Related to University Drop-out and Persistence

PubMed Central

Bernardo, Ana; Esteban, María; Fernández, Estrella; Cervero, Antonio; Tuero, Ellián; Solano, Paula

2016-01-01

Dropping out of university has serious consequences not only for the student who drops out but also for the institution and society as a whole. Although this phenomenon has been widely studied, there is a need for broader knowledge of the context in which it occurs. Yet research on the subject often focuses on variables that, although they affect drop-out rates, lie beyond a university’s control. This makes it hard to come up with effective preventive measures. That is why a northern Spanish university has undertaken a ex post facto holistic research study on 1,311 freshmen (2008/9, 2009/10, and 2010/11 cohorts). The study falls within the framework of the ALFA-GUIA European Project and focuses on those drop-out factors where there is scope for taking remedial measures. This research explored the possible relationship of degree drop-out and different categories of variables: variables related to the educational stage prior to university entry (path to entry university and main reason for degree choice), variables related to integration and coexistence at university (social integration, academic integration, relationships with teachers/peers and value of the living environment) financial status and performance during university studies (in terms of compliance with the program, time devoted to study, use of study techniques and class attendance). Descriptive, correlational and variance analyses were conducted to discover which of these variables really distinguish those students who drop-out from their peers who complete their studies. Results highlight the influence of vocation as main reason for degree choice, path to university entry, financial independency, social and academic adaptation, time devoted to study, use of study techniques and program compliance in the studied phenomenon. PMID:27803684

Insights into the role of components of the tumor microenvironment in oral carcinoma call for new therapeutic approaches

DOE Office of Scientific and Technical Information (OSTI.GOV)

Salo, Tuula, E-mail: Tuula.salo@oulu.fi; Oulu University Central Hospital, Oulu; Institute of Dentistry, University of Helsinki, Helsinki

The research on oral cancer has focused mainly on the cancer cells, their genetic changes and consequent phenotypic modifications. However, it is increasingly clear that the tumor microenvironment (TME) has been shown to be in a dynamic state of inter-relations with the cancer cells. The TME contains a variety of components including the non-cancerous cells (i.e., immune cells, resident fibroblasts and angiogenic vascular cells) and the ECM milieu [including fibers (mainly collagen and fibronectin) and soluble factors (i.e., enzymes, growth factors, cytokines and chemokines)]. Thus, it is currently assumed that TME is considered a part of the cancerous tissue andmore » the functionality of its key components constitutes the setting on which the hallmarks of the cancer cells can evolve. Therefore, in terms of controlling a malignancy, one should control the growth, invasion and spread of the cancer cells through modifications in the TME components. This mini review focuses on the TME as a diagnostic approach and reports the recent insights into the role of different TME key components [such as carcinoma-associated fibroblasts (CAFs) and inflammation (CAI) cells, angiogenesis, stromal matrix molecules and proteases] in the molecular biology of oral carcinoma. Furthermore, the impact of TME components on clinical outcomes and the concomitant need for development of new therapeutic approaches will be discussed. - Highlights: • Tumor depth and budding, hypoxia and TME cells associate with worse prognosis. • Pro-tumoral CAFs and CAI cells aid proliferation, invasion and spread hypoxia. • Some ECM-bound factors exert pro-angiogenic or pro-tumor activities. • Tumor spread is greatly dependent on ECM proteolysis, mediated by TME cells. • Direct targeting of TME components for treatment is still experimental.« less

How does the tobacco industry attempt to influence marketing regulations? A systematic review.

PubMed

Savell, Emily; Gilmore, Anna B; Fooks, Gary

2014-01-01

The Framework Convention on Tobacco Control makes a number of recommendations aimed at restricting the marketing of tobacco products. Tobacco industry political activity has been identified as an obstacle to Parties' development and implementation of these provisions. This study systematically reviews the existing literature on tobacco industry efforts to influence marketing regulations and develops taxonomies of 1) industry strategies and tactics and 2) industry frames and arguments. Searches were conducted between April-July 2011, and updated in March 2013. Articles were included if they made reference to tobacco industry efforts to influence marketing regulations; supported claims with verifiable evidence; were written in English; and concerned the period 1990-2013. 48 articles met the review criteria. Narrative synthesis was used to combine the evidence. 56% of articles focused on activity in North America, Europe or Australasia, the rest focusing on Asia (17%), South America, Africa or transnational activity. Six main political strategies and four main frames were identified. The tobacco industry frequently claims that the proposed policy will have negative unintended consequences, that there are legal barriers to regulation, and that the regulation is unnecessary because, for example, industry does not market to youth or adheres to a voluntary code. The industry primarily conveys these arguments through direct and indirect lobbying, the promotion of voluntary codes and alternative policies, and the formation of alliances with other industrial sectors. The majority of tactics and arguments were used in multiple jurisdictions. Tobacco industry political activity is far more diverse than suggested by existing taxonomies of corporate political activity. Tactics and arguments are repeated across jurisdictions, suggesting that the taxonomies of industry tactics and arguments developed in this paper are generalisable to multiple jurisdictions and can be used to predict industry activity.

How Does the Tobacco Industry Attempt to Influence Marketing Regulations? A Systematic Review

PubMed Central

Savell, Emily; Gilmore, Anna B.; Fooks, Gary

2014-01-01

Background The Framework Convention on Tobacco Control makes a number of recommendations aimed at restricting the marketing of tobacco products. Tobacco industry political activity has been identified as an obstacle to Parties’ development and implementation of these provisions. This study systematically reviews the existing literature on tobacco industry efforts to influence marketing regulations and develops taxonomies of 1) industry strategies and tactics and 2) industry frames and arguments. Methods Searches were conducted between April-July 2011, and updated in March 2013. Articles were included if they made reference to tobacco industry efforts to influence marketing regulations; supported claims with verifiable evidence; were written in English; and concerned the period 1990–2013. 48 articles met the review criteria. Narrative synthesis was used to combine the evidence. Results 56% of articles focused on activity in North America, Europe or Australasia, the rest focusing on Asia (17%), South America, Africa or transnational activity. Six main political strategies and four main frames were identified. The tobacco industry frequently claims that the proposed policy will have negative unintended consequences, that there are legal barriers to regulation, and that the regulation is unnecessary because, for example, industry does not market to youth or adheres to a voluntary code. The industry primarily conveys these arguments through direct and indirect lobbying, the promotion of voluntary codes and alternative policies, and the formation of alliances with other industrial sectors. The majority of tactics and arguments were used in multiple jurisdictions. Conclusions Tobacco industry political activity is far more diverse than suggested by existing taxonomies of corporate political activity. Tactics and arguments are repeated across jurisdictions, suggesting that the taxonomies of industry tactics and arguments developed in this paper are generalisable to multiple jurisdictions and can be used to predict industry activity. PMID:24505286

Approach to cardio-oncologic patients with special focus on patients with cardiac implantable electronic devices planned for radiotherapy: results of the European Heart Rhythm Association survey.

PubMed

Lenarczyk, Radoslaw; Potpara, Tatjana S; Haugaa, Kristina H; Deharo, Jean-Claude; Hernandez-Madrid, Antonio; Del Carmen Exposito Pineda, Maria; Kiliszek, Marek; Dagres, Nikolaos

2017-09-01

The aim of this European Heart Rhythm Association (EHRA) survey was to evaluate clinical practice regarding cardio-oncologic patients, with special focus on patients with cardiac implantable electronic devices (CIEDs) planned for anticancer radiotherapy (RT), among members of the EHRA electrophysiology research network. Of the 36 responding centres, 89% managed patients who were diagnosed or treated oncologically, and this diagnosis affected 1-5% of cardiovascular patients in majority of centres (57%). The main side effects of anticancer therapy in patients treated by cardiologists were thromboembolic complications and left ventricular dysfunction (both reported as 'frequent' by 43% of the centres). The main agents associated with complications were anthracyclines, RT, and monoclonal antibodies. Echocardiography was the most common method of screening for cardiovascular complications (93%), and 10% of the centres did not routinely screen for treatment-induced cardiotoxicity. Opinions on the safe radiation dose, methods of device shielding, and risk calculation prior to RT in CIED patients differed among centres. Precaution measures in high-risk CIED patients were very heterogeneous among centres. Our survey has shown that the awareness of cardiac consequences of anticancer therapy is high, despite relatively low proportion of patients treated oncologically among all cardiovascular patients. There is a consensus of which screening methods should be used for cardiotoxicity of anticancer treatment, but the apprehension of screening necessity is low. Methods of risk assessment and safety measures in CIED patients undergoing RT are very heterogeneous among the European centres, underscoring the need for standardization of the approach to cardio-oncologic patients. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2017. For Permissions, please email: journals.permissions@oup.com.

Response and recovery measures for two floods in north China during the nineteenth century: a comparative study.

PubMed

Ye, Yu; Fang, Xiuqi; Li, Fan

2016-01-01

The process of human response to natural disasters and its mechanisms as revealed by historical events still has a broad significance for modern society. This study analyzed the disaster relief process and the social response for two floods in China: the Yongding River flood in 1801 and the Yellow River flood in 1841. These two floods reflect the different response processes between the national and provincial capitals during a stage of climate cooling and social transition in the Qing dynasty. Applying methods of historical documents analysis and qualitatively comparative analysis to the materials such as Relief Chronicles Authorized by the Emperor in XinYou and Flood Description in Bian Liang , it shows that: (1) In 1801, the central government took on a lead position, from flood surveying to relief processes. However, local government and gentries played an important role in 1841. (2) In 1801, the government successfully undertook a series of relief measures addressing production, housing, food prices, taxes, and water conservancy and administration. In 1841, the response measures were relatively simple, focusing mainly on providing shelter and food for victims. (3) The government carried out long-term disaster prevention measures such as dredging channels after the flood in 1801. In 1841, however, the efforts were focused mainly on emergency rescue. (4) Refugees in the 1801 flood were effectively managed by a centralized authority. In 1841, regulation of the flooding was delayed by corruption and conflicts between officers, leading to an expansion of the disaster's impact. Above results have led to the conclusion that disaster relief systems and response measures had a significant effect on the consequences of those floods. Various flood relief measures and natural disasters management regimes have implications for contemporary flood hazard mitigation.

Positive aspects of caregiving in schizophrenia: A review

PubMed Central

Kulhara, Parmanand; Kate, Natasha; Grover, Sandeep; Nehra, Ritu

2012-01-01

Schizophrenia is a severe mental illness which is associated with significant consequences for both the patients and their relatives. Due to chronicity of the illness, the relatives of patients of schizophrenia have to bear the main brunt of the illness. Studies across the world have evaluated various aspects of caregiving and caregivers such as burden, coping, quality of life, social support, expressed emotions, and psychological morbidity. In general the research has looked at caregiving as a negative phenomenon, however, now it is increasingly recognised that caregiving is not only associated with negative consequences only, also experience subjective gains and satisfaction. This review focus on the conceptual issues, instruments available to assess the positive aspects of caregiving and the various correlates of positive aspects of caregiving reported in relation to schizophrenia. The positive aspect of caregiving has been variously measured as positive caregiving experience, caregiving satisfaction, caregiving gains and finding meaning through caregiving scale and positive aspects of caregiving experience. Studies suggests that caregivers of patients with schizophrenia and psychotic disorders experience caregiving gains (in the form of becoming more sensitive to persons with disabilities, clarity about their priorities in life and a greater sense of inner strength), experience good aspects of relationship with the patient, do have personal positive experiences. Some of the studies suggest that those who experience greater negative caregiving experience also do experience positive caregiving experience. PMID:24175167

Effects of the economic crisis on health and healthcare in Greece in the literature from 2009 to 2013: a systematic review.

PubMed

Simou, Effie; Koutsogeorgou, Eleni

2014-04-01

Due to the current economic crisis in Greece, effects on health and healthcare have been reported. The aim of this study was to present a systematic overview of the consequences that the financial crisis has had for health and healthcare in Greece. Systematic literature review was conducted in order to identify articles that were published from January 2009 to March 2013 and explicitly referred to the effects of economic crisis on health or healthcare, in Greece. Data extraction and synthesis was performed with the use of thematic analysis. Thirty-nine studies were considered for further analyses. Various existing and potential relevant effects were identified, including reductions in public health expenditure and changes in healthcare services and the pharmaceutical market, with an increasing number of admissions in public healthcare sector, and efficiency and organizational-related issues being evident, overall. Indications were found for post-crisis deterioration of public health with increasing rates of mental health, suicides, and epidemics, and deterioration of self-rated health. The recent efforts to reform the Greek National Health System have been focusing mainly on short-term effects by reducing expenditure, while the measures imposed seem to have dubious long-term consequences for Greek public health and healthcare. Copyright © 2014 The Authos. Published by Elsevier Ireland Ltd.. All rights reserved.

Peripheral Glial Cells in the Development of Diabetic Neuropathy.

PubMed

Gonçalves, Nádia Pereira; Vægter, Christian Bjerggaard; Pallesen, Lone Tjener

2018-01-01

The global prevalence of diabetes is rapidly increasing, affecting more than half a billion individuals within the next few years. As diabetes negatively affects several physiological systems, this dramatic increase represents not only impaired quality of life on the individual level but also a huge socioeconomic challenge. One of the physiological consequences affecting up to half of diabetic patients is the progressive deterioration of the peripheral nervous system, resulting in spontaneous pain and eventually loss of sensory function, motor weakness, and organ dysfunctions. Despite intense research on the consequences of hyperglycemia on nerve functions, the biological mechanisms underlying diabetic neuropathy are still largely unknown, and treatment options lacking. Research has mainly focused directly on the neuronal component, presumably from the perspective that this is the functional signal-transmitting unit of the nerve. However, it is noteworthy that each single peripheral sensory neuron is intimately associated with numerous glial cells; the neuronal soma is completely enclosed by satellite glial cells and the length of the longest axons covered by at least 1,000 Schwann cells. The glial cells are vital for the neuron, but very little is still known about these cells in general and especially how they respond to diabetes in terms of altered neuronal support. We will discuss current knowledge of peripheral glial cells and argue that increased research in these cells is imperative for a better understanding of the mechanisms underlying diabetic neuropathy.

Aging impact on biochemical activities and gene expression of Drosophila melanogaster mitochondria.

PubMed

Dubessay, Pascal; Garreau-Balandier, Isabelle; Jarrousse, Anne-Sophie; Fleuriet, Annie; Sion, Benoit; Debise, Roger; Alziari, Serge

2007-08-01

The consequences of aging are characterized by a decline in the main cellular functions, including those of the mitochondria. Although these consequences have been much studied, efforts have often focused solely on a few parameters used to assess the "state" of mitochondrial function during aging. We performed comparative measurements of several parameters in young (a few days) and old (8 and 12 weeks) adult male Drosophila melanogaster: respiratory complex activities, mitochondrial respiration, ATP synthesis, lipid composition of the inner membrane, concentrations of respiratory complex subunits, expression of genes (nuclear and mitochondrial) coding for mitochondrial proteins. Our results show that, in the mitochondria of "old" flies, the activities of three respiratory complexes (I, III, IV) are greatly diminished, ATP synthesis is decreased, and the lipid composition of the inner membrane (fatty acids, cardiolipin) is modified. However, the respiration rate and subunit concentrations measured by Western blot are unaffected. Although cellular mitochondrial DNA (mtDNA) content remains constant, there is a decrease in concentrations of nuclear and mitochondrial transcripts apparently coordinated. The expression of nuclear genes encoding the transcription factors TFAM, TFB1, TFB2, and DmTTF, which are essential for the maintenance and expression of mtDNA are also decreased. The decrease in nuclear and mitochondrial transcript concentrations may be one of the principal effects of aging on mitochondria, and could explain observed decreases in mitochondrial efficiency.

Peripheral Glial Cells in the Development of Diabetic Neuropathy

PubMed Central

Gonçalves, Nádia Pereira; Vægter, Christian Bjerggaard; Pallesen, Lone Tjener

2018-01-01

The global prevalence of diabetes is rapidly increasing, affecting more than half a billion individuals within the next few years. As diabetes negatively affects several physiological systems, this dramatic increase represents not only impaired quality of life on the individual level but also a huge socioeconomic challenge. One of the physiological consequences affecting up to half of diabetic patients is the progressive deterioration of the peripheral nervous system, resulting in spontaneous pain and eventually loss of sensory function, motor weakness, and organ dysfunctions. Despite intense research on the consequences of hyperglycemia on nerve functions, the biological mechanisms underlying diabetic neuropathy are still largely unknown, and treatment options lacking. Research has mainly focused directly on the neuronal component, presumably from the perspective that this is the functional signal-transmitting unit of the nerve. However, it is noteworthy that each single peripheral sensory neuron is intimately associated with numerous glial cells; the neuronal soma is completely enclosed by satellite glial cells and the length of the longest axons covered by at least 1,000 Schwann cells. The glial cells are vital for the neuron, but very little is still known about these cells in general and especially how they respond to diabetes in terms of altered neuronal support. We will discuss current knowledge of peripheral glial cells and argue that increased research in these cells is imperative for a better understanding of the mechanisms underlying diabetic neuropathy. PMID:29770116

Measuring the impact of alcohol-related disorders on quality of life through general population preferences.

PubMed

Rodríguez-Míguez, Eva; Mosquera Nogueira, Jacinto

To estimate the intangible effects of alcohol misuse on the drinker's quality of life, based on general population preferences METHODS: The most important effects (dimensions) were identified by means of two focus groups conducted with patients and specialists. The levels of these dimensions were combined to yield different scenarios. A sample of 300 people taken from the general Spanish population evaluated a subset of these scenarios, selected by using a fractional factorial design. We used the probability lottery equivalent method to derive the utility score for the evaluated scenarios, and the random-effects regression model to estimate the relative importance of each dimension and to derive the utility score for the rest of scenarios not directly evaluated. Four main dimensions were identified (family, physical health, psychological health and social) and divided into three levels of intensity. We found a wide variation in the utilities associated with the scenarios directly evaluated (ranging from 0.09 to 0.78). The dimensions with the greatest relative importance were physical health (36.4%) and family consequences (31.3%), followed by psychological (20.5%) and social consequences (11.8%). Our findings confirm the benefits of adopting a heterogeneous approach to measure the effects of alcohol misuse. The estimated utilities could have both clinical and economic applications. Copyright © 2016 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

[Caregiving consequences in mental disorders--definitions and instruments of assessment].

PubMed

Ciałkowska-Kuźmińska, Magdalena; Kiejna, Andrzej

2010-01-01

Severe mental illnesses have far-reaching consequences for both patients and their relatives. This paper reviews literature on the measures of caregiving consequences. Authors provide a condensed knowledge and research results in the area of caregiving consequences, especially both subjective and objective caregivers' burden. The consequences of care apply to carers' social and leisure activities, financial status, health condition. The burden of care has three fundamental causes: the reorganisation of mental health services, a social isolation of patients and their families and the lack of systemic support for caregivers. The problem of caregiving consequences has been investigated in several studies. In order to identify factors, which have impact on caregiver distress, a variety instruments have been developed. This paper focuses on questionnaires useful for the systematic assessment of both objective and subjective burden: Involvement Evaluation Questionnaire (IEQ), Perceived Family Burden Scale (PFBS), Zarit Caregiver Burden Scale (ZCBS), Experience of Caregiving Inventory (ECI), Family Problems Questionnaire (FPQ). The mentioned instruments proved to be a reliable instrument for measuring caregiver consequences in mental healthcare.

Short-sighted confession decisions: the role of uncertain and delayed consequences.

PubMed

Yang, Yueran; Madon, Stephanie; Guyll, Max

2015-02-01

Suspects have a propensity to focus on short-term contingencies, giving disproportionate weight to the proximal consequences that are delivered by police during an interrogation, and too little consideration to the distal (and often more severe) consequences that may be levied by the judicial system if they are convicted. In this research, the authors examined whether the perceived uncertainty and temporal distance of distal consequences contribute to this propensity. Using the repetitive question paradigm (Madon et al., 2012), participants (N = 209) were interviewed about 20 prior criminal and unethical behaviors and were required to admit or deny each one. Participants' denials and admissions were paired with both a proximal consequence and a distal consequence, respectively. Results indicated that the distal consequence had less impact on participants' admission decisions when it was uncertain and temporally remote. These results provide evidence that the perceived uncertainty and temporal distance of future punishment are key factors that lead suspects to confess to crimes in exchange for short-term gains.

Plasma induced DNA damage: Comparison with the effects of ionizing radiation

NASA Astrophysics Data System (ADS)

Lazović, S.; Maletić, D.; Leskovac, A.; Filipović, J.; Puač, N.; Malović, G.; Joksić, G.; Petrović, Z. Lj.

2014-09-01

We use human primary fibroblasts for comparing plasma and gamma rays induced DNA damage. In both cases, DNA strand breaks occur, but of fundamentally different nature. Unlike gamma exposure, contact with plasma predominantly leads to single strand breaks and base-damages, while double strand breaks are mainly consequence of the cell repair mechanisms. Different cell signaling mechanisms are detected confirming this (ataxia telangiectasia mutated - ATM and ataxia telangiectasia and Rad3 related - ATR, respectively). The effective plasma doses can be tuned to match the typical therapeutic doses of 2 Gy. Tailoring the effective dose through plasma power and duration of the treatment enables safety precautions mainly by inducing apoptosis and consequently reduced frequency of micronuclei.

When Directors Leave: The Causes and Consequences of Center Administrative Changes

ERIC Educational Resources Information Center

Whitebook, Marcy; Sakai, Laura

2004-01-01

Policymakers and researchers have focused attention on the significant role that directors play in building and sustaining high-quality child care programs. However, there has been limited focus on director turnover and its implications for programs. This article summarizes findings from the longitudinal study, "Then and Now: Changes in Child Care…

Learning with Computer-Based Multimedia: Gender Effects on Efficiency

ERIC Educational Resources Information Center

Pohnl, Sabine; Bogner, Franz X.

2012-01-01

Up to now, only a few studies in multimedia learning have focused on gender effects. While research has mostly focused on learning success, the effect of gender on instructional efficiency (IE) has not yet been considered. Consequently, we used a quasi-experimental design to examine possible gender differences in the learning success, mental…

Chilling Admissions: The Affirmative Action Crisis and the Search for Alternatives.

ERIC Educational Resources Information Center

Orfield, Gary, Ed.; Miller, Edward, Ed.

This book, produced by the Harvard Civil Rights Project, focuses on the consequences for student body diversity of eliminating race and ethnicity as factors in university admissions. The more specific focus is on what would happen if college admissions relied entirely on traditional quantitative measures of academic achievement and promise, such…

Persuasiveness of Anti-Smoking Messages: Self-Construal and Message Focus

ERIC Educational Resources Information Center

Yang, Bo; Nan, Xiaoli; Zhao, Xinyan

2017-01-01

Purpose: The purpose of this paper is to examine the role of independent vs interdependent self-construal in non-smokers' responses to an anti-smoking message that focuses on either personal or relational consequences of smoking. Design/methodology/approach: Two web-based experimental studies were conducted among US college non-smokers. In the…

Receive, Reorganize, Return: Theatre as Creative Scholarship

ERIC Educational Resources Information Center

Armstrong, Sara; Braunschneider, Theresa

2016-01-01

This article focuses on the use of theatre as a mode of creative scholarship, from the research involved in sketch creation to the presentation of that research to academic audiences. We particularly focus on a specific sketch developed by the CRLT Players--one that explores the consequences of subtle discrimination faced by women scientists in…

The Effectiveness of Staff Training Focused on Increasing Emotional Intelligence and Improving Interaction between Support Staff and Clients

ERIC Educational Resources Information Center

Zijlmans, L. J. M.; Embregts, P. J. C. M.; Gerits, L.; Bosman, A. M. T.; Derksen, J. J. L.

2015-01-01

Background: Recent research addressed the relationship between staff behaviour and challenging behaviour of individuals with an intellectual disability (ID). Consequently, research on interventions aimed at staff is warranted. The present study focused on the effectiveness of a staff training aimed at emotional intelligence and interactions…

Converging levels of analysis in the cognitive neuroscience of visual attention.

PubMed Central

Duncan, J

1998-01-01

Experiments using behavioural, lesion, functional imaging and single neuron methods are considered in the context of a neuropsychological model of visual attention. According to this model, inputs compete for representation in multiple visually responsive brain systems, sensory and motor, cortical and subcortical. Competition is biased by advance priming of neurons responsive to current behavioural targets. Across systems competition is integrated such that the same, selected object tends to become dominant throughout. The behavioural studies reviewed concern divided attention within and between modalities. They implicate within-modality competition as one main restriction on concurrent stimulus identification. In contrast to the conventional association of lateral attentional focus with parietal lobe function, the lesion studies show attentional bias to be a widespread consequence of unilateral cortical damage. Although the clinical syndrome of unilateral neglect may indeed be associated with parietal lesions, this probably reflects an assortment of further deficits accompanying a simple attentional imbalance. The functional imaging studies show joint involvement of lateral prefrontal and occipital cortex in lateral attentional focus and competition. The single unit studies suggest how competition in several regions of extrastriate cortex is biased by advance priming of neurons responsive to current behavioural targets. Together, the concepts of competition, priming and integration allow a unified theoretical approach to findings from behavioural to single neuron levels. PMID:9770224

Antimony bioavailability: knowledge and research perspectives for sustainable agricultures.

PubMed

Pierart, Antoine; Shahid, Muhammad; Séjalon-Delmas, Nathalie; Dumat, Camille

2015-05-30

The increasing interest in urban agriculture highlights the crucial question of crop quality. The main objectives for environmental sustainability are a decrease in chemical inputs, a reduction in the level of pollutants, and an improvement in the soil's biological activity. Among inorganic pollutants emitted by vehicle traffic and some industrial processes in urban areas, antimony (Sb) is observed on a global scale. While this metalloid is known to be potentially toxic, it can transfer from the soil or the atmosphere to plants, and accumulate in their edible parts. Urban agriculture is developing worldwide, and could therefore increasingly expose populations to Sb. The objective of this review was in consequences to gather and interpret actual knowledge of Sb uptake and bioaccumulation by crops, to reveal investigative fields on which to focus. While there is still no legal maximal value for Sb in plants and soils, light has to be shed on its accumulation and the factors affecting it. A relative absence of data exists about the role of soil flora and fauna in the transfer, speciation and compartmentation of Sb in vegetables. Moreover, little information exists on Sb ecotoxicity for terrestrial ecosystems. A human risk assessment has finally been reviewed, with particular focus on Sb bioaccessibility. Copyright © 2015 Elsevier B.V. All rights reserved.

Direct contact membrane distillation for textile wastewater treatment: a state of the art review.

PubMed

Ramlow, Heloisa; Machado, Ricardo Antonio Francisco; Marangoni, Cintia

2017-11-01

To meet surging water demands, water reuse is being sought as an alternative to traditional water resources. Direct contact membrane distillation (DCMD) has been increasingly studied in the past decade for its potential as an emerging cost effective wastewater treatment process and subsequent water reuse. This review presents a comprehensive overview of the current progress in the application of DCMD for textile wastewater treatment based on the available state of the art. There are already published review papers about the membrane distillation process, but the difference in the present work is that it focuses on the textile area, which consumes a lot of water and generates large amounts of wastewater, and still needs innovations in the sector. A review focused on the textile sector draws the attention of professionals to the problem and, consequently, to a solution. Current issues such as the influences of feed solution, membrane characteristics and membrane fouling and new insights are discussed. The main performance operating conditions and their effects on the separation process are given. Likewise, challenges associated with the influence of different dyes on the DCMD results are explained. This review also highlights the future research directions for DCMD to achieve successful implementation in the textile industry.

Introduction: Cardiovascular physics

NASA Astrophysics Data System (ADS)

Wessel, Niels; Kurths, Jürgen; Ditto, William; Bauernschmitt, Robert

2007-03-01

The number of patients suffering from cardiovascular diseases increases unproportionally high with the increase of the human population and aging, leading to very high expenses in the public health system. Therefore, the challenge of cardiovascular physics is to develop high-sophisticated methods which are able to, on the one hand, supplement and replace expensive medical devices and, on the other hand, improve the medical diagnostics with decreasing the patient's risk. Cardiovascular physics-which interconnects medicine, physics, biology, engineering, and mathematics-is based on interdisciplinary collaboration of specialists from the above scientific fields and attempts to gain deeper insights into pathophysiology and treatment options. This paper summarizes advances in cardiovascular physics with emphasis on a workshop held in Bad Honnef, Germany, in May 2005. The meeting attracted an interdisciplinary audience and led to a number of papers covering the main research fields of cardiovascular physics, including data analysis, modeling, and medical application. The variety of problems addressed by this issue underlines the complexity of the cardiovascular system. It could be demonstrated in this Focus Issue, that data analyses and modeling methods from cardiovascular physics have the ability to lead to significant improvements in different medical fields. Consequently, this Focus Issue of Chaos is a status report that may invite all interested readers to join the community and find competent discussion and cooperation partners.

The nature of nurture and the future of evodevo: toward a theory of developmental evolution.

PubMed

Moczek, Armin P

2012-07-01

This essay has three parts. First, I posit that much research in contemporary evodevo remains steeped in a traditional framework that views traits and trait differences as being caused by genes and genetic variation, and the environment as providing an external context in which development and evolution unfold. Second, I discuss three attributes of organismal development and evolution, broadly applicable to all organisms and traits that call into question the usefulness of gene- and genome-centric views of development and evolution. I then focus on the third and main aim of this essay and ask: what conceptual and empirical opportunities exist that would permit evodevo research to transcend the traditional boundaries inherited from its parent disciplines and to move toward the development of a more comprehensive and realistic theory of developmental evolution? Here, I focus on three conceptual frameworks, the theory of facilitated variation, the theory of evolution by genetic accommodation, and the theory of niche construction. I conclude that combined they provide a rich, interlocking framework within which to revise existing and develop novel empirical approaches toward a better understanding of the nature of developmental evolution. Examples of such approaches are highlighted, and the consequences of expanding existing frameworks are discussed.

Country roads, take me home… to my friends: How intelligence, population density, and friendship affect modern happiness.

PubMed

Li, Norman P; Kanazawa, Satoshi

2016-11-01

We propose the savanna theory of happiness, which suggests that it is not only the current consequences of a given situation but also its ancestral consequences that affect individuals' life satisfaction and explains why such influences of ancestral consequences might interact with intelligence. We choose two varied factors that characterize basic differences between ancestral and modern life - population density and frequency of socialization with friends - as empirical test cases. As predicted by the theory, population density is negatively, and frequency of socialization with friends is positively, associated with life satisfaction. More importantly, the main associations of life satisfaction with population density and socialization with friends significantly interact with intelligence, and, in the latter case, the main association is reversed among the extremely intelligent. More intelligent individuals experience lower life satisfaction with more frequent socialization with friends. This study highlights the utility of incorporating evolutionary perspectives in the study of subjective well-being. © 2016 The British Psychological Society.

Explanations of illness experiences among community mental health patients: an argument for the use of an ethnographic interview method in routine clinical care.

PubMed

Owiti, John A; Palinski, Andrea; Ajaz, Ali; Ascoli, Micol; De Jongh, Bertine; Bhui, Kamaldeep S

2015-02-01

Cultural variations in perceptions of mental distress are important issues for healthcare. They can affect communication between patients and professionals and may be a root cause for misdiagnosis, patient disengagement, and disparities in access, outcomes and overall experiences of treatment by patients. Taking into account patients' explanatory models (EMs) of mental distress is fundamental to patient-centred care, and improved outcomes. This paper reports on the outcomes from the Cultural Consultation Service, commissioned in an inner-city London borough. We used a narrative-based ethnographic method of assessment, in which community mental health patients referred for a cultural consultation were interviewed using Barts Explanatory Model Inventory and Checklist (BEMI) to assess the EMs of their mental distress. Patients mainly attributed the causes and consequences of their mental distress to emotional and psychological factors, which were inextricably linked to existing social concerns and interpersonal issues. Desired solutions mainly focused on treatment, social, and systemic interventions. We found that using BEMI could contribute to a comprehensive assessment in routine care and can be used by professionals within a short timeframe and with minimal training. Ethnographic assessment method captures patients' EMs and illness experiences, opening the way for patient-centred interventions and potentially better outcomes and experiences.

Overview of the molecular defense systems used by sea urchin embryos to cope with UV radiation.

PubMed

Bonaventura, Rosa; Matranga, Valeria

2017-07-01

The sea urchin embryo is a well-recognized developmental biology model and its use in toxicological studies has been widely appreciated. Many studies have focused on the evaluation of the effects of chemical stressors and their mixture in marine ecosystems using sea urchin embryos. These are well equipped with defense genes used to cope with chemical stressors. Recently, ultraviolet radiation (UVR), particularly UVB (280-315 nm), received more attention as a physical stressor. Mainly in the Polar Regions, but also at temperate latitudes, the penetration of UVB into the oceans increases as a consequence of the reduction of the Earth's ozone layer. In general, UVR induces oxidative stress in marine organisms affecting molecular targets such as DNA, proteins, and lipids. Depending on the UVR dose, developing sea urchin embryos show morphological perturbations affecting mainly the skeleton formation and patterning. Nevertheless, embryos are able to protect themselves against excessive UVR, using mechanisms acting at different levels: transcriptional, translational and post-translational. In this review, we recommend the sea urchin embryo as a suitable model for testing physical stressors such as UVR and summarize the mechanisms adopted to deal with UVR. Moreover, we review UV-induced apoptotic events and the combined effects of UVR and other stressors. Copyright © 2016 Elsevier Ltd. All rights reserved.

Resurgence of emerald shiners Notropis atherinoides in Lake Huron's main basin

USGS Publications Warehouse

Schaeffer, J.S.; Warner, D.M.; O'Brien, T. P.

2008-01-01

Emerald shiners Notropis atherinoides were formerly common in Lakes Huron and Michigan, but declined during the 1960s as the exotic alewife Alosa pseudoharengus proliferated. The Lake Huron emerald shiner population was chronically depressed through 2004; however, we detected resurgence in emerald shiner density and biomass in Lake Huron during acoustic and midwater trawl surveys conducted during 2004-2006. Emerald shiners were not found during 2004, but by 2006 main basin density exceeded 500 fish/ha, biomass estimates exceeded 0.5 kg/ha, and emerald shiners contributed more to pelagic biomass than alewives or rainbow smelt Osmerus mordax. Length frequency distributions suggested that increased density was the result of two consecutive strong year classes in 2005 and 2006. Emerald shiner distributions also expanded from a focus in western Lake Huron in 2005 to a lakewide distribution in 2006. Emerald shiners occurred offshore, but were nearly always associated with epilimnetic surface waters warmer than 19??C. Resurgence of emerald shiners was likely a consequence of reduced alewife abundance, as they declined concurrently with alewife proliferation during the early 1960s. Return of this species may benefit native nearshore piscivores; however, benefits to Pacific salmonids Oncorhynchus spp. are uncertain because emerald shiners are smaller and still less abundant than historically important prey species, and they may be thermally segregated from salmonines.

Doping in sport: effects, harm and misconceptions.

PubMed

Birzniece, V

2015-03-01

Doping in sport is a widespread problem not just among elite athletes, but even more so in recreational sports. In scientific literature, major emphasis is placed on doping detection, whereas detrimental effects of doping agents on athletes' health are seldom discussed. Androgenic anabolic steroids are well known for their positive effects on muscle mass and strength. Human growth hormone also increases muscle mass, although the majority of that is an increase in extracellular fluid and not the functional muscle mass. In recreational athletes, growth hormone does not have major effect on muscle strength, power or aerobic capacity, but stimulates anaerobic exercise capacity. Erythropoietin administration increases oxygen-carrying capacity of blood improving endurance measures, whereas systemic administration of beta-adrenergic agonists may have positive effect on sprint capacity, and beta-adrenergic antagonists reduce muscle tremor. Thus, there are certain drugs that can improve selective aspects of physical performance. However, most of the doping agents exert serious side-effects, especially when used in combination, at high doses and for a long duration. The extent of long-term health consequences is difficult to predict, but likely to be substantial, especially when gene doping is considered. This review summarises the main groups of doping agents used by athletes, with the main focus on their effects on athletic performance and adverse effects. © 2014 Royal Australasian College of Physicians.

The Youth Employment Problem--Dimensions, Causes and Consequences. Research on Youth Employment and Employability Development. Youth Knowledge Development Report 2.9.

ERIC Educational Resources Information Center

Freeman, Richard B.; And Others

This collection of papers on the youth employment problem consists of 15 papers that cover the dimensions, causes, and consequences of youth unemployment and that also focus on problems in measuring the extent of the problem, the dynamic aspects of youth labor force participation, and problems associated with adequately assessing the consequences…

Global consequences of unsafe abortion.

PubMed

Singh, Susheela

2010-11-01

Unsafe abortion is a significant cause of death and ill health in women in the developing world. A substantial body of research on these consequences exists, although studies are of variable quality. However, unsafe abortion has a number of other significant consequences that are much less widely recognized. These include the economic consequences, the immediate costs of providing medical care for abortion-related complications, the costs of medical care for longer-term health consequences, lost productivity to the country, the impact on families and the community, and the social consequences that affect women and families. This article will review the scientific evidence on the consequences of unsafe abortion, highlight gaps in the evidence base, suggest areas where future research efforts are needed, and speculate on the future situation regarding consequences and evidence over the next 5-10 years. The information provided is useful and timely given the current heightened interest in the issue of unsafe abortion, growing from the recent focus of national and international agencies on reducing maternal mortality by 75% by 2015 (as one of the Millennium Development Goals established in 2000).

Disclosure of HIV Serostatus and Sexual Orientation Among HIV-Positive Men Who Have Sex with Men in China.

PubMed

Lin, Xiuyun; Chi, Peilian; Zhang, Liying; Zhang, Yan; Fang, Xiaoyi; Qiao, Shan; Li, Xiaoming

2016-05-01

This study addressed the issue of disclosing HIV status and sexual orientation, and explored the consequences of such disclosures among HIV-positive men who have sex with men (MSM) in China. In-depth individual interviews were conducted with 37 HIV-positive MSM. Of these participants, 3 (8.1%) disclosed neither their HIV status nor their sexual orientation to anyone; 24 (64.9%) voluntarily disclosed both their HIV-positive status and their sexual orientation; 7 (18.9%) voluntarily disclosed their HIV status only, and 3 (8.1%) involuntarily disclosed their HIV status and sexual orientation. Parents, partners, siblings and close friends were the most common disclosure targets. HIV-positive MSM were less likely to disclose their sexual orientation than their HIV status. The positive consequences of disclosure included receiving support, acquiring family care, reducing stress, improving mood and developing more positive values and beliefs. The negative consequences included the participants' perception of rejection and stigma toward themselves and their families. However, the stigma mainly comes from "outsiders" rather than family members and close friends. We did not find any differences with respect to consequences between participants who disclosed their HIV status only and those who disclosed both their HIV status and sexual orientation. In conclusion, partners, siblings and friends were main disclosure targets, and HIV positive MSM preferred to disclose their HIV serostatus than their sexual orientation. Voluntarily disclosing one's HIV status to significant others resulted in more positive consequences than negative consequences. Theses results were informative for developing mental health and coping interventions.

Physician Dual Practice: A Descriptive Mapping Review of Literature.

PubMed

Moghri, Javad; Arab, Mohammad; Rashidian, Arash; Akbari Sari, Ali

2016-03-01

Physician dual practice is a common phenomenon in almost all countries throughout the world, which could potential impacts on access, equity and quality of services. This paper aims to review studies in physician dual practice and categorize them in order to their main objectives and purposes. Comprehensive literature searches were undertaken in order to obtain main papers and documents in the field of physician dual practice. Systematic searches in Medline and Embase from 1960 to 2013, and general searches in some popular search engines were carried out in this way. After that, descriptive mapping review methods were utilized to categorize eligible studies in this area. The searches obtained 404 titles, of which 81 full texts were assessed. Finally, 24 studies were eligible for inclusion in our review. These studies were categorized into four groups - "motivation and forces behind dual practice", "consequences of dual practice", "dual practice Policies and their impacts", and "other studies" - based on their main objectives. Our findings showed a dearth of scientifically reliable literature in some areas of dual practice, like the prevalence of the phenomenon, the real consequences of it, and the impacts of the implemented policy measures. Rigorous empirical and evaluative studies should be designed to detect the real consequences of DP and assess the effects of interventions and regulations, which governments have implemented in this field.

Mapping patients' experiences after stroke onto a patient-focused intervention framework.

PubMed

Donnellan, C; Martins, A; Conlon, A; Coughlan, T; O'Neill, D; Collins, D R

2013-03-01

Stroke patients' involvement in the rehabilitation process including decision making has made significant advances clinically over the past two decades. However, development of patient-focused interventions in stroke rehabilitation is a relatively under developed area of research. The aim of this study was to interpret the explanations that patients gave of their experience after stroke and how these may validate an already established patient-focused intervention framework - the Quest for quality and improved performance (QQUIP) (2006) that includes seven quality improvement goals. A random purposive sample of eight stroke patients was interviewed between 3 and 6 months following discharge. Patients' reports of their experience after stroke were obtained using in-dept semi-structured interviews and analysed using Qualitative Content Analysis. Explanations given by patients included both positive and negative reports of the stroke experience. Regardless of consequences as a result of physical, psychological and social impairments, there were other life style disruptions that were reported by all patients such as taking new medication and adverse effects of these, experiencing increasing fatigue, difficulties with social activities and situations and having to make changes in health behaviours and lifestyle. Some of the core themes that emerged reflected the aims of QQUIP improvement goals that include improving health literacy, clinical decision-making, self-care, patient safety, access to health advice, care experience and service development. Further recommendations based on the findings from this study would be to consider using the QQUIP framework for developing intervention studies in stroke rehabilitation care that are person-centred. This framework provides a template that is equipped to address some of the main concerns that people have following the experience of stroke and also focuses on improving quality of care.

Images of Polar Bears and Penguins, Storms, Deforestation and More - Middle School Students Perceptions of Climate Change

NASA Astrophysics Data System (ADS)

Gopal, S.; Melaas, E. K.; Malmrose, M.; Mullokandov, A.

2014-12-01

Global change studies aim to foster a deeper understanding of the causes and consequences of global change on planet Earth. The study of global change presents a rich domain of inquiry, exploration, and discovery at all grade levels. The main objective of this exploratory study was to assess middle school students' perceptions of global change as part of their participation in the NSF GK12 program called GLACIER (Global Change Initiative - Education and Research) during the academic year 2012-13. The middle schools are located in the Metro Boston area. As part of the program, participating students were asked to draw pictures of their perceptions and ideas on global change. The drawings of 150 children, ages 11 to 13, were qualitatively analyzed. The analysis focused on (a) the type of concepts children chose to convey, (b) the specific context of the global change described (polar bears in floating glaciers), (c) students direct representation of anthropocentric impacts (such as pollution or deforestation), and (d) the match between students concepts and the recent IPCC reports. About 20% of the students focused on the iconic imagery of the melting glaciers and impact on animals such as penguins and polar bears, more than 25% focused on natural disasters (such as storms, sea level changes) while 30% focused on urban problems. These concepts are matched with the recent IPCC report. These results are notable and suggest students in middle schools understand the varied dimensions of global change and the role of human activities in bringing about change. Students' perspectives may help in developing a suitable curriculum using existing science standards to discuss this significant topic in middle school classrooms. In addition, students' drawings illustrate their perception of the coupled human and natural systems.

Implementing shared decision-making: consider all the consequences.

PubMed

Elwyn, Glyn; Frosch, Dominick L; Kobrin, Sarah

2016-08-08

The ethical argument that shared decision-making is "the right" thing to do, however laudable, is unlikely to change how healthcare is organized, just as evidence alone will be an insufficient factor: practice change is governed by factors such as cost, profit margin, quality, and efficiency. It is helpful, therefore, when evaluating new approaches such as shared decision-making to conceptualize potential consequences in a way that is broad, long-term, and as relevant as possible to multiple stakeholders. Yet, so far, evaluation metrics for shared decision-making have been mostly focused on short-term outcomes, such as cognitive or affective consequences in patients. The goal of this article is to hypothesize a wider set of consequences, that apply over an extended time horizon, and include outcomes at interactional, team, organizational and system levels, and to call for future research to study these possible consequences. To date, many more studies have evaluated patient decision aids rather than other approaches to shared decision-making, and the outcomes measured have typically been focused on short-term cognitive and affective outcomes, for example knowledge and decisional conflict. From a clinicians perspective, the shared decision-making process could be viewed as either intrinsically rewarding and protective, or burdensome and impractical, yet studies have not focused on the impact on professionals, either positive or negative. At interactional levels, group, team, and microsystem, the potential long-term consequences could include the development of a culture where deliberation and collaboration are regarded as guiding principles, where patients are coached to assess the value of interventions, to trade-off benefits versus harms, and assess their burdens-in short, to new social norms in the clinical workplace. At organizational levels, consistent shared decision-making might boost patient experience evaluations and lead to fewer complaints and legal challenges. In the long-term, shared decision-making might lead to changes in resource utilization, perhaps to reductions in cost, and to modification of workforce composition. Despite the gradual shift to value-based payment, some organizations, motivated by continued income derived from achieving high volumes of procedures and contacts, will see this as a negative consequence. We suggest that a broader conceptualization and measurement of shared decision-making would provide a more substantive evidence base to guide implementation. We outline a framework which illustrates a hypothesized set of proximal, distal, and distant consequences that might occur if collaboration and deliberation could be achieved routinely, proposing that well-informed preference-based patient decisions might lead to safer, more cost-effective healthcare, which in turn might result in reduced utilization rates and improved health outcomes.

The Research Assessment Exercise in Hong Kong: Positive and Negative Consequences

ERIC Educational Resources Information Center

Currie, Jan

2008-01-01

This article reports findings from 39 interviews from two Hong Kong universities and offers a critique of the RAE system. Respondents stated that the main emphasis in counting research productivity was on articles in prestigious international journals. There were many negative comments about this as the main quality indicator. Some respondents…

ValWorkBench: an open source Java library for cluster validation, with applications to microarray data analysis.

PubMed

Giancarlo, R; Scaturro, D; Utro, F

2015-02-01

The prediction of the number of clusters in a dataset, in particular microarrays, is a fundamental task in biological data analysis, usually performed via validation measures. Unfortunately, it has received very little attention and in fact there is a growing need for software tools/libraries dedicated to it. Here we present ValWorkBench, a software library consisting of eleven well known validation measures, together with novel heuristic approximations for some of them. The main objective of this paper is to provide the interested researcher with the full software documentation of an open source cluster validation platform having the main features of being easily extendible in a homogeneous way and of offering software components that can be readily re-used. Consequently, the focus of the presentation is on the architecture of the library, since it provides an essential map that can be used to access the full software documentation, which is available at the supplementary material website [1]. The mentioned main features of ValWorkBench are also discussed and exemplified, with emphasis on software abstraction design and re-usability. A comparison with existing cluster validation software libraries, mainly in terms of the mentioned features, is also offered. It suggests that ValWorkBench is a much needed contribution to the microarray software development/algorithm engineering community. For completeness, it is important to mention that previous accurate algorithmic experimental analysis of the relative merits of each of the implemented measures [19,23,25], carried out specifically on microarray data, gives useful insights on the effectiveness of ValWorkBench for cluster validation to researchers in the microarray community interested in its use for the mentioned task. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Beyond drinking: differential effects of demographic and socioeconomic factors on alcohol-related adverse consequences across European countries.

PubMed

Kuendig, Hervé; Plant, Moira L; Plant, Martin A; Kuntsche, Sandra; Miller, Patrick; Gmel, Gerhard; Ahlström, Salme; Bergmark, Karin Helmersson; Olafsdóttir, Hildigunnur; Elekes, Zsuzsanna; Csemy, Ladislav; Knibbe, Ronald

2008-01-01

Evidence underlines the importance of drinking patterns and individual characteristics in experiencing adverse alcohol-related consequences; however, little research has been conducted to explore who does and who does not experience consequences with similar drinking patterns. Using data from seven European countries, this study assesses the association between demographic and socioeconomic characteristics and six adverse consequences. Conditional logistic regression models were estimated, cases (experiencing a consequence) being matched to controls (not experiencing the consequence) by drinking patterns. In general, protective effects with increasing age and being in a partnership were consistent. Gender effects were mixed, but mainly protective for women. Educational achievement and economic status showed consistent effects across countries, but different directions of effect across consequences. Consequences mostly associated with individual drinking pattern (injury, blackout, and loss of control over drinking) exhibited similar patterns of associations, but varying ones arose for consequences additionally influenced by societal reaction to drinking (guilt, role failure, and pressure to cut down drinking). Differences in strengths and directions of effects across consequences pointed to the possibility that the reporting of adverse consequences is not only influenced by alcohol consumption, but also by attributional processes related to demographic and socioeconomic statuses. Copyright 2008 S. Karger AG, Basel.

Physiological consequences of CPAP therapy withdrawal in patients with obstructive sleep apnoea-an opportunity for an efficient experimental model.

PubMed

Schwarz, Esther I; Stradling, John R; Kohler, Malcolm

2018-01-01

Randomised controlled trials (RCTs) of continuous positive airway pressure (CPAP) in obstructive sleep apnoea (OSA) are time consuming, and their findings often inconclusive or limited due to suboptimal CPAP adherence in CPAP-naïve patients with OSA. Short-term CPAP withdrawal in patients with prior optimal CPAP adherence results in recurrence of OSA and its consequences. Thus, this experimental model serves as an efficient tool to investigate both the consequences of untreated OSA, and potential treatment alternatives to CPAP. The CPAP withdrawal protocol has been thoroughly validated, and applied in several RCTs focusing on cardiovascular and metabolic consequences of untreated OSA, as well as the assessment of treatment alternatives to CPAP.

Physiological consequences of CPAP therapy withdrawal in patients with obstructive sleep apnoea—an opportunity for an efficient experimental model

PubMed Central

Stradling, John R.; Kohler, Malcolm

2018-01-01

Randomised controlled trials (RCTs) of continuous positive airway pressure (CPAP) in obstructive sleep apnoea (OSA) are time consuming, and their findings often inconclusive or limited due to suboptimal CPAP adherence in CPAP-naïve patients with OSA. Short-term CPAP withdrawal in patients with prior optimal CPAP adherence results in recurrence of OSA and its consequences. Thus, this experimental model serves as an efficient tool to investigate both the consequences of untreated OSA, and potential treatment alternatives to CPAP. The CPAP withdrawal protocol has been thoroughly validated, and applied in several RCTs focusing on cardiovascular and metabolic consequences of untreated OSA, as well as the assessment of treatment alternatives to CPAP. PMID:29445525

Causes and Consequences of Cognitive Functioning Across the Life Course

PubMed Central

Hauser, Robert M.

2012-01-01

Research on variation in cognitive abilities has focused largely on their genetic or experiential sources and on their economic consequences. This article takes a broader look at the consequences of cognitive ability—IQ—across the life course. Contrary to received wisdom, the effects of IQ on economic success are almost entirely mediated by educational attainment. Among persons with equal levels of schooling, IQ has little influence on job performance, occupational standing, earnings, or wealth. But there are other, sometimes surprising consequences of IQ throughout adult life. The long-term correlates of adolescent cognition include drinking behavior, survey participation, Internet use, and the timing of menopause. These are surveyed primarily using findings from the Wisconsin Longitudinal Study. PMID:22383855

Message framing and defensive processing: a cultural examination.

PubMed

Ko, Deborah M; Kim, Heejung S

2010-01-01

Past research has shown that health messages on safer sexual practices that focus on relational consequences are more persuasive than messages that focus on personal consequences. However, we theorize that it is defensiveness against personal risk framing that threatens the self among people from more individualistic cultures. Two studies tested this idea. Study 1 showed that European Americans were less persuaded by personal framing than by relational framing but that this pattern was not found for Asian Americans, who are more collectivistic. Study 2 showed that these defensive patterns were eliminated among European American participants when a person's self-image was affirmed. These results suggest defensive processes as the mechanism behind the differences in message framing effectiveness and motivate a closer look at cultural patterns.

Changes in dietary habits after migration and consequences for health: a focus on South Asians in Europe

PubMed Central

Holmboe-Ottesen, Gerd; Wandel, Margareta

2012-01-01

Background Immigrants from low-income countries comprise an increasing proportion of the population in Europe. Higher prevalence of obesity and nutrition related diseases, such as type 2 diabetes (T2D) and cardiovascular disease (CVD) is found in some immigrant groups, especially in South Asians. Aim To review dietary changes after migration and discuss the implication for health and prevention among immigrants from low-income countries to Europe, with a special focus on South Asians. Method Systematic searches in PubMed were performed to identify relevant high quality review articles and primary research papers. The searches were limited to major immigrant groups in Europe, including those from South Asia (India, Pakistan, Bangladesh, Sri Lanka). Articles in English from 1990 and onwards from Europe were included. For health implications, recent review articles and studies of particular relevance to dietary changes among South Asian migrants in Europe were chosen. Results Most studies report on dietary changes and health consequences in South Asians. The picture of dietary change is complex, depending on a variety of factors related to country of origin, urban/rural residence, socio-economic and cultural factors and situation in host country. However, the main dietary trend after migration is a substantial increase in energy and fat intake, a reduction in carbohydrates and a switch from whole grains and pulses to more refined sources of carbohydrates, resulting in a low intake of fiber. The data also indicate an increase in intake of meat and dairy foods. Some groups have also reduced their vegetable intake. The findings suggest that these dietary changes may all have contributed to higher risk of obesity, T2D and CVD. Implications for prevention A first priority in prevention should be adoption of a low-energy density – high fiber diet, rich in whole grains and grain products, as well as fruits, vegetables and pulses. Furthermore, avoidance of energy dense and hyperprocessed foods is an important preventive measure. PMID:23139649

The Ionospheric Scintillation Effects on the BeiDou Signal Receiver

PubMed Central

He, Zhijun; Zhao, Hongbo; Feng, Wenquan

2016-01-01

Irregularities in the Earth’s ionosphere can make the amplitude and phase of radio signals fluctuate rapidly, which is known as ionospheric scintillation. Severe ionospheric scintillation could affect the performance of the Global Navigation Satellite System (GNSS). Currently, the Multiple Phase Screen (MPS) technique is widely used in solving problems caused by weak and strong scintillations. Considering that Southern China is mainly located in the area where moderate and intense scintillation occur frequently, this paper built a model based on the MPS technique and discussed the scintillation impacts on China’s BeiDou navigation system. By using the BeiDou B1I signal, this paper analyzed the scintillation effects on the receiver, which includes the acquisition and tracking process. For acquisition process, this paper focused on the correlation peak and acquisition probability. For the tracking process, this paper focused on the carrier tracking loop and the code tracking loop. Simulation results show that under high scintillation intensity, the phase fluctuation could be −1.13 ± 0.087 rad to 1.40 ± 0.087 rad and the relative amplitude fluctuation could be −10 dB to 8 dB. As the scintillation intensity increased, the average correlation peak would decrease more than 8%, which could thus degrade acquisition performance. On the other hand, when the signal-to-noise ratio (SNR) is comparatively lower, the influence of strong scintillation on the phase locked loop (PLL) is much higher than that of weak scintillation. As the scintillation becomes more intense, PLL variance could consequently results in an error of more than 2.02 cm in carrier-phase based ranging. In addition, the delay locked loop (DLL) simulation results indicated that the pseudo-range error caused by strong scintillation could be more than 4 m and the consequent impact on positioning accuracy could be more than 6 m. PMID:27834867

Resilience among asylum seekers living with HIV

PubMed Central

2012-01-01

Background A small body of evidence demonstrates the challenges faced by migrant communities living with HIV but has yet to consider in-depth the experience of asylum seekers whose residency status is undetermined. The overall aim of our study was to explore the experiences of those who are both living with HIV and seeking asylum. This paper focuses on the stressors precipitated by the HIV diagnosis and by going through the asylum system; as well as participants’ resilience in responding to these stressors and the consequences for their health and wellbeing. Methods We conducted an ethnographic study. Fieldwork took place in the UK between 2008–2009 and included: 350 hours of observation at voluntary services providing support to black and minority ethnic groups living with HIV; 29 interviews and four focus group discussions with those who were seeking asylum and living with HIV; and 15 interviews with their health and social care providers. Data were analysed using the constant comparative method. Results There were three main stressors that threatened participants’ resilience. First, migration caused them to leave behind many resources (including social support). Second, stigmatising attitudes led their HIV diagnosis to be a taboo subject furthering their isolation. Third, they found themselves trapped in the asylum system, unable to influence the outcome of their case and reliant on HIV treatment to stay alive. Participants were, however, very resourceful in dealing with these experiences. Resilience processes included: staying busy, drawing on personal faith, and the support received through HIV care providers and voluntary organisations. Even so, their isolated existence meant participants had limited access to social resources, and their treatment in the asylum system had a profound impact on perceived health and wellbeing. Conclusions Asylum seekers living with HIV in the UK show immense resilience. However, their isolation means they are often unable to deal with their treatment in the asylum system, with negative consequences for their perceived health and wellbeing. PMID:23110402

Alcohol-induced blackouts: A review of recent clinical research with practical implications and recommendations for future studies

PubMed Central

Wetherill, Reagan R.; Fromme, Kim

2016-01-01

Background Alcohol-induced blackouts, or memory loss for all or portions of events that occurred during a drinking episode, are reported by approximately 50% of drinkers and are associated with a wide range of negative consequences, including injury and death. As such, identifying the factors that contribute to and result from alcohol-induced blackouts is critical in developing effective prevention programs. Here, we provide an updated review (2010–2015) of clinical research focused on alcohol-induced blackouts, outline practical and clinical implications, and provide recommendations for future research. Methods A comprehensive, systematic literature review was conducted to examine all articles published between January 2010 through August 2015 that focused on examined vulnerabilities, consequences, and possible mechanisms for alcohol-induced blackouts. Results Twenty-sex studies reported on alcohol-induced blackouts. Fifteen studies examined prevalence and/or predictors of alcohol-induced blackouts. Six publications described consequences of alcohol-induced blackouts, and five studies explored potential cognitive and neurobiological mechanisms underlying alcohol-induced blackouts. Conclusions Recent research on alcohol-induced blackouts suggests that individual differences, not just alcohol consumption, increase the likelihood of experiencing an alcohol-induced blackout, and the consequences of alcohol-induced blackouts extend beyond the consequences related to the drinking episode to include psychiatric symptoms and neurobiological abnormalities. Prospective studies and a standardized assessment of alcohol-induced blackouts are needed to fully characterize factors associated with alcohol-induced blackouts and to improve prevention strategies. PMID:27060868

Alcohol-Induced Blackouts: A Review of Recent Clinical Research with Practical Implications and Recommendations for Future Studies.

PubMed

Wetherill, Reagan R; Fromme, Kim

2016-05-01

Alcohol-induced blackouts, or memory loss for all or portions of events that occurred during a drinking episode, are reported by approximately 50% of drinkers and are associated with a wide range of negative consequences, including injury and death. As such, identifying the factors that contribute to and result from alcohol-induced blackouts is critical in developing effective prevention programs. Here, we provide an updated review (2010 to 2015) of clinical research focused on alcohol-induced blackouts, outline practical and clinical implications, and provide recommendations for future research. A comprehensive, systematic literature review was conducted to examine all articles published between January 2010 through August 2015 that focused on vulnerabilities, consequences, and possible mechanisms for alcohol-induced blackouts. Twenty-six studies reported on alcohol-induced blackouts. Fifteen studies examined prevalence and/or predictors of alcohol-induced blackouts. Six publications described the consequences of alcohol-induced blackouts, and 5 studies explored potential cognitive and neurobiological mechanisms underlying alcohol-induced blackouts. Recent research on alcohol-induced blackouts suggests that individual differences, not just alcohol consumption, increase the likelihood of experiencing an alcohol-induced blackout, and the consequences of alcohol-induced blackouts extend beyond the consequences related to the drinking episode to include psychiatric symptoms and neurobiological abnormalities. Prospective studies and a standardized assessment of alcohol-induced blackouts are needed to fully characterize factors associated with alcohol-induced blackouts and to improve prevention strategies. Copyright © 2016 by the Research Society on Alcoholism.

Practice Makes Perfect and Other Curricular Myths in the Sport Specialization Debate

ERIC Educational Resources Information Center

Brylinsky, Jody

2010-01-01

This article presents a different focus on the specialization debate, one that changes the focus to the quality of sport instruction regardless of the level of specialization in training. It suggests that many of the negative consequences of early sport specialization may be avoided with appropriate coaching and sport skill instruction. Rather…

Beyond Individual War Trauma: Domestic Violence against Children in Afghanistan and Sri Lanka

ERIC Educational Resources Information Center

Catani, Claudia; Schauer, Elisabeth; Neuner, Frank

2008-01-01

To date, research on the psychosocial consequences of mass trauma resulting from war and organized violence on children has primarily focused on the individual as the unit of treatment and analysis with particular focus on mental disorders caused by traumatic stress. This body of research has stimulated the development of promising…

Caribbean landscapes and their biodiversity

Treesearch

A. E. Lugo; E. H. Helmer; E. Santiago Valentín

2012-01-01

Both the biodiversity and the landscapes of the Caribbean have been greatly modified as a consequence of human activity. In this essay we provide an overview of the natural landscapes and biodiversity of the Caribbean and discuss how human activity has affected both. Our Caribbean geographic focus is on the insular Caribbean and the biodiversity focus is on the flora,...

New Organisational Structures and the Transformation of Academic Work

ERIC Educational Resources Information Center

Nyhagen, Gigliola Mathisen; Baschung, Lukas

2013-01-01

This article will particularly focus on Norway and the consequences for academic work. Frequently in studies of academic work, focus has been on academics' individual autonomy and to what extent the latter is challenged (Altbach in "Ann Am Acad Pol Soc Sci" 448:1-14, 1980; Shattock in "High Educ" 41:27-47, 2001). One of the…

Consequences of migration and remittances for Mexican transnational communities.

PubMed

Conway, D; Cohen, J H

1998-01-01

"Our aims in this paper are to broaden explanation of remittance expenditures and to evaluate the positive contributions of remittances, return migrants, or circulating sojourners. Specifically focusing on the situation in ¿home' communities, we illustrate the multifaceted consequences of remittances and migration, emphasizing positive nonmonetary and social impacts." Data are from ethnographic research carried out in 1992-1993 in Santa Ana del Valle, Oaxaca, Mexico. excerpt

School Food Unwrapped: What's Available and What Our Kids Actually Are Eating. Research Brief. Publication #2008-40

ERIC Educational Resources Information Center

Hair, Elizabeth; Ling, Thomson; Wandner, Laura

2008-01-01

Childhood obesity has emerged as a critical health problem of the 21st century. The seriousness of this issue stems from the grave health consequences of overweight and obesity that begin in child-hood and persist later in life. In light of these consequences, public health officials and others have begun to focus on schools as key settings in…

Perceptions of climate change across the Canadian forest sector: The key factors of institutional and geographical environment.

PubMed

Ameztegui, Aitor; Solarik, Kevin A; Parkins, John R; Houle, Daniel; Messier, Christian; Gravel, Dominique

2018-01-01

Assessing the perception of key stakeholders within the forest sector is critical to evaluating their readiness to engage in adapting to climate change. Here, we report the results of the most comprehensive survey carried out in the Canadian forestry sector to date regarding perceptions of climate change. A total of 1158 individuals, representing a wide range of stakeholders across the five most important forestry provinces in Canada, were asked about climate change, its impact on forest ecosystems, and the suitability of current forest management for addressing future impacts. Overall, we found that respondents were more concerned about climate change than the general population. More than 90% of respondents agreed with the anthropogenic origins of climate change, and > 50% considered it a direct threat to their welfare. Political view was the main driver of general beliefs about the causes of climate change and its future consequences, while the province of origin proved to be the best predictor of perceived current impacts on forest ecosystems and its associated risks; and type of stakeholder was the main driver of perceived need for adaptation. Industrial stakeholders were the most skeptical about the anthropogenic cause(s) of climate change (18% disagreed with this statement, compared to an average of 8% in the other stakeholders), its impacts on forest ecosystems (28% for industry vs. 10% for other respondents), and the need for new management practices (18% vs. 7%). Although the degree of awareness and the willingness to implement adaptive practices were high even for the most skeptical groups, our study identified priority sectors or areas for action when designing awareness campaigns. We suggest that the design of a strategic framework for implementing climate adaptation within the Canadian forest sector should focus on the relationship between climate change and changes in disturbance regimes, and above all on the economic consequences of these changes, but it should also take into account the positions shown by each of the actors in each province.

Perceptions of climate change across the Canadian forest sector: The key factors of institutional and geographical environment

PubMed Central

Parkins, John R.; Houle, Daniel; Messier, Christian; Gravel, Dominique

2018-01-01

Assessing the perception of key stakeholders within the forest sector is critical to evaluating their readiness to engage in adapting to climate change. Here, we report the results of the most comprehensive survey carried out in the Canadian forestry sector to date regarding perceptions of climate change. A total of 1158 individuals, representing a wide range of stakeholders across the five most important forestry provinces in Canada, were asked about climate change, its impact on forest ecosystems, and the suitability of current forest management for addressing future impacts. Overall, we found that respondents were more concerned about climate change than the general population. More than 90% of respondents agreed with the anthropogenic origins of climate change, and > 50% considered it a direct threat to their welfare. Political view was the main driver of general beliefs about the causes of climate change and its future consequences, while the province of origin proved to be the best predictor of perceived current impacts on forest ecosystems and its associated risks; and type of stakeholder was the main driver of perceived need for adaptation. Industrial stakeholders were the most skeptical about the anthropogenic cause(s) of climate change (18% disagreed with this statement, compared to an average of 8% in the other stakeholders), its impacts on forest ecosystems (28% for industry vs. 10% for other respondents), and the need for new management practices (18% vs. 7%). Although the degree of awareness and the willingness to implement adaptive practices were high even for the most skeptical groups, our study identified priority sectors or areas for action when designing awareness campaigns. We suggest that the design of a strategic framework for implementing climate adaptation within the Canadian forest sector should focus on the relationship between climate change and changes in disturbance regimes, and above all on the economic consequences of these changes, but it should also take into account the positions shown by each of the actors in each province. PMID:29897977

Sunlight damage to cellular DNA: Focus on oxidatively generated lesions.

PubMed

Schuch, André Passaglia; Moreno, Natália Cestari; Schuch, Natielen Jacques; Menck, Carlos Frederico Martins; Garcia, Camila Carrião Machado

2017-06-01

The routine and often unavoidable exposure to solar ultraviolet (UV) radiation makes it one of the most significant environmental DNA-damaging agents to which humans are exposed. Sunlight, specifically UVB and UVA, triggers various types of DNA damage. Although sunlight, mainly UVB, is necessary for the production of vitamin D, which is necessary for human health, DNA damage may have several deleterious consequences, such as cell death, mutagenesis, photoaging and cancer. UVA and UVB photons can be directly absorbed not only by DNA, which results in lesions, but also by the chromophores that are present in skin cells. This process leads to the formation of reactive oxygen species, which may indirectly cause DNA damage. Despite many decades of investigation, the discrimination among the consequences of these different types of lesions is not clear. However, human cells have complex systems to avoid the deleterious effects of the reactive species produced by sunlight. These systems include antioxidants, that protect DNA, and mechanisms of DNA damage repair and tolerance. Genetic defects in these mechanisms that have clear harmful effects in the exposed skin are found in several human syndromes. The best known of these is xeroderma pigmentosum (XP), whose patients are defective in the nucleotide excision repair (NER) and translesion synthesis (TLS) pathways. These patients are mainly affected due to UV-induced pyrimidine dimers, but there is growing evidence that XP cells are also defective in the protection against other types of lesions, including oxidized DNA bases. This raises a question regarding the relative roles of the various forms of sunlight-induced DNA damage on skin carcinogenesis and photoaging. Therefore, knowledge of what occurs in XP patients may still bring important contributions to the understanding of the biological impact of sunlight-induced deleterious effects on the skin cells. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Modulation of the GABAergic pathway for the treatment of fragile X syndrome.

PubMed

Lozano, Reymundo; Hare, Emma B; Hagerman, Randi J

2014-01-01

Fragile X syndrome (FXS) is the most common genetic cause of intellectual disability and the most common single-gene cause of autism. It is caused by mutations on the fragile X mental retardation gene (FMR1) and lack of fragile X mental retardation protein, which in turn, leads to decreased inhibition of translation of many synaptic proteins. The metabotropic glutamate receptor (mGluR) hypothesis states that the neurological deficits in individuals with FXS are due mainly to downstream consequences of overstimulation of the mGluR pathway. The main efforts have focused on mGluR5 targeted treatments; however, investigation on the gamma-aminobutyric acid (GABA) system and its potential as a targeted treatment is less emphasized. The fragile X mouse models (Fmr1-knock out) show decreased GABA subunit receptors, decreased synthesis of GABA, increased catabolism of GABA, and overall decreased GABAergic input in many regions of the brain. Consequences of the reduced GABAergic input in FXS include oversensitivity to sensory stimuli, seizures, and anxiety. Deficits in the GABA receptors in different regions of the brain are associated with behavioral and attentional processing deficits linked to anxiety and autistic behaviors. The understanding of the neurobiology of FXS has led to the development of targeted treatments for the core behavioral features of FXS, which include social deficits, inattention, and anxiety. These symptoms are also observed in individuals with autism and other neurodevelopmental disorders, therefore the targeted treatments for FXS are leading the way in the treatment of other neurodevelopmental syndromes and autism. The GABAergic system in FXS represents a target for new treatments. Herein, we discuss the animal and human trials of GABAergic treatment in FXS. Arbaclofen and ganaxolone have been used in individuals with FXS. Other potential GABAergic treatments, such as riluzole, gaboxadol, tiagabine, and vigabatrin, will be also discussed. Further studies are needed to determine the safety and efficacy of GABAergic treatments for FXS.

Floods of the Lower Tisza from the late 17th century onwards: frequency, magnitude, seasonality and great flood events

NASA Astrophysics Data System (ADS)

Kiss, Andrea

2016-04-01

The present paper is based on a recently developed database including contemporary original, administrative, legal and private source materials (published and archival) as well as media reports related to the floods occurred on the lower sections of the Tisza river in Hungary, with special emphasis on the area of Szeged town. The study area is well-represented by contemporary source evidence from the late 17th century onwards, when the town and its broader area was reoccupied from the Ottoman Turkish Empire. Concerning the applied source materials, the main bases of investigation are the administrative (archival) sources such as town council protocols of Szeged and county meeting protocols of Csanád and Csongrád Counties. In these (legal-)administrative documents damaging events (natural/environmental hazards) were systematically recorded. Moreover, other source types such as taxation-related damage accounts as well as private and official reports, letters and correspondence (published, unpublished) were also included. Concerning published evidence, a most important source is flood reports in contemporary newspapers as well as town chronicles and other contemporary narratives. In the presentation the main focus is on the analysis of flood-rich flood-poor periods of the last ca. 330 years; moreover, the seasonality distribution as well as the magnitude of Tisza flood events are also discussed. Another important aim of the poster is to provide a short overview, in the form of case studies, on the greatest flood events (e.g. duration, magnitude, damages, multi-annual consequences), and their further impacts on the urban and countryside development as well as on (changes in) flood defence strategies. In this respect, especially two flood events, the great (1815-)1816 and the catastrophic 1879 flood (shortly with causes and consequences) - that practically erased Szeged town from the ground - are presented in more detail.

A Moveable Feast: Insects Moving at the Forest-Crop Interface Are Affected by Crop Phenology and the Amount of Forest in the Landscape.

PubMed

González, Ezequiel; Salvo, Adriana; Defagó, María Teresa; Valladares, Graciela

2016-01-01

Edges have become prevailing habitats, mainly as a result of habitat fragmentation and agricultural expansion. The interchange of functionally relevant organisms like insects occurs through these edges and can influence ecosystem functioning in both crop and non-crop habitats. However, very few studies have focused on the directionality of insect movement through edges, and the role of crop and non-crop amount has been ignored. Using bi-directional flight interception traps we investigated interchange of herbivore, natural enemy, pollinator and detritivore insects between native forest fragments and soybean crops, simultaneously considering movement direction, forest cover in the landscape and crop phenology. In total, 52,173 specimens and 877 morphospecies were collected. We found that, within most functional and taxonomic groups, movement intensity was similar (richness and/or abundance) between directions, whereas a predominantly forest-to-crop movement characterized natural enemies. Insect movement was extensively affected by crop phenology, decreasing during crop senescence, and was enhanced by forest cover particularly at senescence. Mainly the same herbivore species moved to and from the forest, but different natural enemy species predominated in each direction. Finally, our analyses revealed greater forest contribution to natural enemy than to herbivore communities in the crop, fading with distance to the forest in both groups. By showing that larger amounts of forest lead to richer insect interchange, in both directions and in four functional groups, our study suggests that allocation to natural and cultivated habitats at landscape level could influence functioning of both systems. Moreover, natural enemies seemed to benefit more than pests from natural vegetation, with natural enemy spillover from forests likely contributing to pest control in soybean fields. Thus consequences of insect interchange seem to be mostly positive for the agroecosystem, although consequences for the natural system deserve further study.

Soil information in the Strategic Environmental Assessment of Rural Development Plans

NASA Astrophysics Data System (ADS)

Costantini, Edoardo

2016-04-01

Soil information is essential for land planning at different administrative levels. Currently, in Europe there is a hierarchy of at least seven main territorial administrative entities which consider soil in their land planning policies. In this study, European, national and regional regulations that affect soil are discussed, considering themes, priorities, and focus areas. A better attention on the Strategic Environmental Assessment (SEA) of the Rural Development Plans (RDP) 2014-2020 is given, by analysing the Environmental Reports produced in the framework of the SEA of the RDP 2014-2020 of some European Regions. Both old and new soil indicators are introduced, as well as the consequences of their adoption for soil science and soil scientists. It is evident from this study that soil information is treated very variably, not only because of the different kinds of available information, but mainly as a consequence of the expertise and sensitivity to the soil issues of the authors, since they can be different kinds of public or private bodies hired by regional authorities. Therefore, despite having the same reference, the SEAs are very different. In most cases, the amount of soil information is little or negligible, even when available. The ex-ante impacts are often only qualitative, or quantified only in terms of the areal extent of applied measures. On the other hand, following the European recommendations, the ongoing and ex-post reports of the monitoring activities of RDP are expected to provide a wealth of soil information, both qualitative and quantitative. Soil scientists, soil and water conservationists, and management experts will be requested to provide more sophisticated and dynamic types of information. Therefore, the SEA of RDP and similar land planning activities will provide greater scientific and technical opportunities for soil science, provided that the public bodies in charge of evaluations, namely Member States, Regions and their auditing counterparts within the European Commission, are able to implement their own recommendations.

Natural hazards and decision-making in the most densely populated country in the American continent: a 20-year perspective

NASA Astrophysics Data System (ADS)

Cruz Martínez, Celina; Cepeda, Jose

2010-05-01

With a population density of ~300 per km2, El Salvador is the most densely populated country in the American continent and the capital, San Salvador, is probably the city in the Americas most frequently hit by natural hazards, earthquakes in particular. As a consequence of a magnitude 5.4 earthquake in 1986, 1500 people were killed, with as many as one-third of these casualties associated to the collapse of engineered structures, a high rate compared to contemporary figures worldwide. Four years earlier, during a long precipitation period in September 1982, a debris flow was triggered from the summit of the San Salvador volcano and travelled ~4 km for about one hour before it killed up to 500 people in an area to the North-West of the Metropolitan Area of San Salvador (AMSS). This same area had been previously hit by a similar event 50 years earlier, but with no consequences at that time since it was uninhabited. These are only some examples of the main facts that motivated the creation of the Office for Urban Planning of the Metropolitan Area of San Salvador (OPAMSS) in 1990. This institution is an autonomous municipal organisation whose functions and attributes comprise the planning and control of urban development. After 20 years of the foundation of OPAMSS, this paper presents its history and evolution, the main achievements and challenges, focusing on how the institution has been shaped by some key milestones, such as the earthquake-triggered landslide at Las Colinas neighbourhood in January 2001, which killed ~600 people in the Western AMSS, and the widespread flooding in October 2005 after the urban drainage network collapsed during Hurricane Stan. The development of OPAMSS as a key organisation in land use management and decision-making is an example that illustrates how the integration of technical and legal aspects can be oriented towards the improvement of governance at the scale of metropolitan areas.

Plasma induced DNA damage: Comparison with the effects of ionizing radiation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lazović, S.; Maletić, D.; Puač, N.

2014-09-22

We use human primary fibroblasts for comparing plasma and gamma rays induced DNA damage. In both cases, DNA strand breaks occur, but of fundamentally different nature. Unlike gamma exposure, contact with plasma predominantly leads to single strand breaks and base-damages, while double strand breaks are mainly consequence of the cell repair mechanisms. Different cell signaling mechanisms are detected confirming this (ataxia telangiectasia mutated - ATM and ataxia telangiectasia and Rad3 related - ATR, respectively). The effective plasma doses can be tuned to match the typical therapeutic doses of 2 Gy. Tailoring the effective dose through plasma power and duration of themore » treatment enables safety precautions mainly by inducing apoptosis and consequently reduced frequency of micronuclei.« less

Actively Coping with Violation: Exploring Upward Dissent Patterns in Functional, Dysfunctional, and Deserted Psychological Contract End States

PubMed Central

Schalk, René; De Ruiter, Melanie; Van Loon, Joost; Kuijpers, Evy; Van Regenmortel, Tine

2018-01-01

Recently, scholars have emphasized the importance of examining how employees cope with psychological contract violation and how the coping process contributes to psychological contract violation resolution and post-violation psychological contracts. Recent work points to the important role of problem-focused coping. Yet, to date, problem-focused coping strategies have not been conceptualized on a continuum from constructive to destructive strategies. Consequently, potential differences in the use of specific types of problem-focused coping strategies and the role these different strategies play in the violation resolution process has not been explored. In this study, we stress the importance of focusing on different types of problem-focused coping strategies. We explore how employee upward dissent strategies, conceptualized as different forms of problem-focused coping, contribute to violation resolution and post-violation psychological contracts. Two sources of data were used. In-depth interviews with supervisors of a Dutch car lease company provided 23 case descriptions of employee-supervisor interactions after a psychological contract violation. Moreover, a database with descriptions of Dutch court sentences provided eight case descriptions of employee-organization interactions following a perceived violation. Based on these data sources, we explored the pattern of upward dissent strategies employees used over time following a perceived violation. We distinguished between functional (thriving and reactivation), dysfunctional (impairment and dissolution) and deserted psychological contract end states and explored whether different dissent patterns over time differentially contributed to the dissent outcome (i.e., psychological contract end state). The results of our study showed that the use of problem-focused coping is not as straightforward as suggested by the post-violation model. While the post-violation model suggests that problem-focused coping will most likely contribute positively to violation resolution, we found that this also depends on the type of problem-focused coping strategy used. That is, more threatening forms of problem-focused coping (i.e., threatening resignation as a way to trigger one’s manager/organization to resolve the violation) mainly contributed to dysfunctional and deserted PC end states. Yet, in some instances the use of these types of active coping strategies also contributed to functional violation resolution. These findings have important implications for the literature on upward dissent strategies and psychological contract violation repair. PMID:29467692

Actively Coping with Violation: Exploring Upward Dissent Patterns in Functional, Dysfunctional, and Deserted Psychological Contract End States.

PubMed

Schalk, René; De Ruiter, Melanie; Van Loon, Joost; Kuijpers, Evy; Van Regenmortel, Tine

2018-01-01

Recently, scholars have emphasized the importance of examining how employees cope with psychological contract violation and how the coping process contributes to psychological contract violation resolution and post-violation psychological contracts. Recent work points to the important role of problem-focused coping. Yet, to date, problem-focused coping strategies have not been conceptualized on a continuum from constructive to destructive strategies. Consequently, potential differences in the use of specific types of problem-focused coping strategies and the role these different strategies play in the violation resolution process has not been explored. In this study, we stress the importance of focusing on different types of problem-focused coping strategies. We explore how employee upward dissent strategies, conceptualized as different forms of problem-focused coping, contribute to violation resolution and post-violation psychological contracts. Two sources of data were used. In-depth interviews with supervisors of a Dutch car lease company provided 23 case descriptions of employee-supervisor interactions after a psychological contract violation. Moreover, a database with descriptions of Dutch court sentences provided eight case descriptions of employee-organization interactions following a perceived violation. Based on these data sources, we explored the pattern of upward dissent strategies employees used over time following a perceived violation. We distinguished between functional (thriving and reactivation), dysfunctional (impairment and dissolution) and deserted psychological contract end states and explored whether different dissent patterns over time differentially contributed to the dissent outcome (i.e., psychological contract end state). The results of our study showed that the use of problem-focused coping is not as straightforward as suggested by the post-violation model. While the post-violation model suggests that problem-focused coping will most likely contribute positively to violation resolution, we found that this also depends on the type of problem-focused coping strategy used. That is, more threatening forms of problem-focused coping (i.e., threatening resignation as a way to trigger one's manager/organization to resolve the violation) mainly contributed to dysfunctional and deserted PC end states. Yet, in some instances the use of these types of active coping strategies also contributed to functional violation resolution. These findings have important implications for the literature on upward dissent strategies and psychological contract violation repair.

The Importance of Assessing Nutritional Status to Ensure Optimal Recovery during the Chronic Phase of Stroke.

PubMed

Serra, Monica C

2018-01-01

Despite evidence that many of the consequences of stroke that hinder recovery (i.e., obesity, muscle atrophy, and functional declines) have nutritionally modifiable behavior components, little attention has been focused on the significance of nutrition beyond the acute phase of stroke. This literature review summarizes the evidence for and against the influence of nutrition on optimal recovery and rehabilitation in chronic (>6 months) stroke. The literature, which is mainly limited to cross-sectional studies, suggests that a suboptimal nutritional status, including an excess caloric intake, reduced protein intake, and micronutrient deficiencies, particularly the B-vitamins, vitamin D, and omega 3 fatty acids, may have deleterious effects on metabolic, physical, and psychological functioning in chronic stroke survivors. Careful evaluation of dietary intake, especially among those with eating disabilities and preexisting malnutrition, may aid in the identification of individuals at increased nutritional risk through which early intervention may benefit recovery and rehabilitation and prevent further complications after stroke.

Potential acidification impacts on zooplankton in CCS leakage scenarios.

PubMed

Halsband, Claudia; Kurihara, Haruko

2013-08-30

Carbon capture and storage (CCS) technologies involve localized acidification of significant volumes of seawater, inhabited mainly by planktonic species. Knowledge on potential impacts of these techniques on the survival and physiology of zooplankton, and subsequent consequences for ecosystem health in targeted areas, is scarce. The recent literature has a focus on anthropogenic greenhouse gas emissions into the atmosphere, leading to enhanced absorption of CO2 by the oceans and a lowered seawater pH, termed ocean acidification. These studies explore the effects of changes in seawater chemistry, as predicted by climate models for the end of this century, on marine biota. Early studies have used unrealistically severe CO2/pH values in this context, but are relevant for CCS leakage scenarios. Little studied meso- and bathypelagic species of the deep sea may be especially vulnerable, as well as vertically migrating zooplankton, which require significant residence times at great depths as part of their life cycle. Copyright © 2013 Elsevier Ltd. All rights reserved.

Multi-color γ-rays from comb-like electron beams driven by incoherent stacks of laser pulses

NASA Astrophysics Data System (ADS)

Kalmykov, S. Y.; Davoine, X.; Ghebregziabher, I.; Shadwick, B. A.

2017-03-01

Trains of fs-length, GeV-scale electron bunches with controlled energy spacing and a 5-D brightness up to 1017 A/m2 may be produced in a mm-scale uniform plasma. The main element of the scheme is an incoherent stack of 10-TW-scale laser pulses of different colors, with mismatched focal spots, with the highest-frequency pulse advanced in time. While driving an electron density bubble, this stack remains almost proof against nonlinear red-shift and self-compression. As a consequence, the unwanted continuous injection of background electrons is minimized. Weak focusing of the trailing (lower-frequency) component of the stack enforces expansions and contractions of the bubble, inducing controlled periodic injection. The resulting train of electron bunches maintains exceptional quality while being accelerated beyond the energy limits predicted by accepted scalings. Inverse Thomson scattering from this comb-like beam generates a sequence of quasi-monochromatic, fs-length γ-ray beams, an asset for nuclear forensics and pump-probe experiments in dense plasmas.

The Use of Tools, Modelling Methods, Data Types, and Endpoints in Systems Medicine: A Survey on Projects of the German e:Med-Programme.

PubMed

Gietzelt, Matthias; Höfer, Thomas; Knaup-Gregori, Petra; König, Rainer; Löpprich, Martin; Poos, Alexandra; Ganzinger, Matthias

2016-01-01

Systems medicine is the consequent continuation of research efforts on the road to an individualized medicine. Thereby, systems medicine tries to offer a holistic view on the patient by combining different data sources to highlight different perspectives on the patient's health. Our research question was to identify the main data types, modelling methods, analysis tools, and endpoints currently used and studied in systems medicine. Therefore, we conducted a survey on projects with a systems medicine background. Fifty participants completed this survey. The results of the survey were analyzed using histograms and cross tables, and finally compared to results of a former literature review with the same research focus. The data types reported in this survey were widely diversified. As expected, genomic and phenotype data were used most frequently. In contrast, environmental and behavioral data were rarely used in the projects. Overall, the cross tables of the data types in the survey and the literature review showed overlapping results.

Advances in pharmacovigilance initiatives surrounding antimicrobial resistance-Indian perspective.

PubMed

Bairy, Laxminarayana Kurady; Nayak, Veena; A, Avinash; Kunder, Sushil Kiran

2016-08-01

In recent years the development of antimicrobial resistance has been accelerating, the discovery of new antimicrobial agents has slowed substantially in past decades. This review mainly focuses on the problem of antimicrobial resistance(AMR); the various contributor mechanisms, consequences and future of AMR. The review also highlights the irrational use of antimicrobials, improving their usage and problems associated with pharmacovigilance of antimicrobial resistance. Pharmacovigilance in the form of surveillance of antibiotic use is being done in 90% of the countries worldwide through the WHONET program developed by WHO. However, the data comes from a limited area of the globe. Data from every part of the world is required, so that there is geographical representation of every region. A major hurdle in quantifying the extent of antimicrobial resistance is the fact that there are several known microbes, that may turn out to be resistant to one or more of the several known antimicrobial agents. The global action plan initiated by WHO, if implemented successfully will definitely reduce AMR and will help in evaluating treatment interventions.

An abbreviated history of osseous surgery.

PubMed

Rudy, Robert J; Marcuschamer, Eduardo

2011-01-01

Various forms of periodontal therapy, including surgery, have been advocated and documented in the dental literature during the last three centuries. This variety of treatment modalities has been developed to address the anatomical consequences (pocket formation and bone loss) sustained from chronic periodontal disease. The marked differences in techniques have created significant controversies between the greatest leaders in dentistry and their equally influential disciples. Nevertheless, these leaders have always shared a common goal: the preservation of the natural dentition in a harmonious environment of health, comfort, and proper function. This article discusses the history of periodontal osseous surgery, including not only the technical issues, but also the conceptual underpinnings of this form of therapeutic intervention. In the process of examining this subject closely, three main controversies in the field of periodontics are brought into sharper focus: non-surgical versus surgical periodontal therapy; gingivectomy versus osseous resective periodontal therapy; and the nature of clinical decision-making: scientific and evidenced-based versus subjective clinical judgement.

Reactive oxygen species, essential molecules, during plant-pathogen interactions.

PubMed

Camejo, Daymi; Guzmán-Cedeño, Ángel; Moreno, Alexander

2016-06-01

Reactive oxygen species (ROS) are continually generated as a consequence of the normal metabolism in aerobic organisms. Accumulation and release of ROS into cell take place in response to a wide variety of adverse environmental conditions including salt, temperature, cold stresses and pathogen attack, among others. In plants, peroxidases class III, NADPH oxidase (NOX) locates in cell wall and plasma membrane, respectively, may be mainly enzymatic systems involving ROS generation. It is well documented that ROS play a dual role into cells, acting as important signal transduction molecules and as toxic molecules with strong oxidant power, however some aspects related to its function during plant-pathogen interactions remain unclear. This review focuses on the principal enzymatic systems involving ROS generation addressing the role of ROS as signal molecules during plant-pathogen interactions. We described how the chloroplasts, mitochondria and peroxisomes perceive the external stimuli as pathogen invasion, and trigger resistance response using ROS as signal molecule. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Contemporary Insights and Novel Treatment Approaches to Central Sleep Apnea Syndrome in Heart Failure

PubMed Central

Grayburn, Ryan L.; Kaka, Yaquta; Wilson Tang, W. H.

2014-01-01

Opinion Statement Central sleep apnea (CSA) is a common and under-diagnosed condition commonly associated with Cheyne-Stokes respiration. It is particularly prevalent in the heart failure population affecting up to 40% of all patients with heart failure. The pathophysiology associated with CSA is based on the underlying effects of hypoventilation and hyperventilation, with neurologic dysregulation of respiratory control as the primary defect. However, therapeutic options are limited due to the prevailing perception that CSA is a consequence, rather than cause of morbidity and mortality. At present, the main focus remains treating the underlying problem (ie intensifying heart failure therapeutics, decongestion), while additional suggestions of using acetazolamide, progesterone, nocturnal oxygen, and theophylline have not been validated with contemporary clinical trials. Positive pressure ventilation is currently the primary recommendation for all patients with sleep-disordered breathing (CSA included), and in some patients may effectively reduce the apnea-hypopnea index. However, significant research is ongoing to determine how to treat this complex patient population. PMID:24874028

Tight Junction Proteins and Oxidative Stress in Heavy Metals-Induced Nephrotoxicity

PubMed Central

Reyes, José L.; Molina-Jijón, Eduardo; Rodríguez-Muñoz, Rafael; Bautista-García, Pablo; Debray-García, Yazmin; Namorado, María del Carmen

2013-01-01

Kidney is a target organ for heavy metals. They accumulate in several segments of the nephron and cause profound alterations in morphology and function. Acute intoxication frequently causes acute renal failure. The effects of chronic exposure have not been fully disclosed. In recent years increasing awareness of the consequences of their presence in the kidney has evolved. In this review we focus on the alterations induced by heavy metals on the intercellular junctions of the kidney. We describe that in addition to the proximal tubule, which has been recognized as the main site of accumulation and injury, other segments of the nephron, such as glomeruli, vessels, and distal nephron, show also deleterious effects. We also emphasize the participation of oxidative stress as a relevant component of the renal damage induced by heavy metals and the beneficial effect that some antioxidant drugs, such as vitamin A (all-trans-retinoic acid) and vitamin E (α-tocopherol), depict on the morphological and functional alterations induced by heavy metals. PMID:23710457

Lifestyle changes in the management of adulthood and childhood obesity.

PubMed

Orio, Francesco; Tafuri, Domenico; Ascione, Antonio; Marciano, Francesca; Savastano, Silvia; Colarieti, Giorgio; Orio, Marcello; Colao, Annamaria; Palomba, Stefano; Muscogiuri, Giovanna

2016-12-01

Adulthood and childhood obesity is rapidly becoming an epidemic problem and it has a short and long-term impact on health. Short-term consequences are mostly represented by psychological effects; in fact obese children have more chances to develop psychological or psychiatric problems than non-obese children. The main long-term effect is represented by the fact that childhood obesity continues into adulthood obesity and this results in negative effects in young adult life, since obesity increases the risk to develop morbidity and premature mortality. The obesity-related diseases are mostly represented by hypertension, type 2 diabetes, dyslipidemia, cardiovascular diseases. Medical treatment should be discouraged in childhood because of the side effects and it should be only reserved for obese children with related medical complications. Lifestyle changes should be encouraged in both adulthood and childhood obesity. This review focuses on the management of obesity both in adulthood and in childhood, paying particular attention to lifestyle changes that should be recommended.

Study of the Size and Shape of Synapses in the Juvenile Rat Somatosensory Cortex with 3D Electron Microscopy

PubMed Central

Rodríguez, José-Rodrigo; DeFelipe, Javier

2018-01-01

Abstract Changes in the size of the synaptic junction are thought to have significant functional consequences. We used focused ion beam milling and scanning electron microscopy (FIB/SEM) to obtain stacks of serial sections from the six layers of the rat somatosensory cortex. We have segmented in 3D a large number of synapses (n = 6891) to analyze the size and shape of excitatory (asymmetric) and inhibitory (symmetric) synapses, using dedicated software. This study provided three main findings. Firstly, the mean synaptic sizes were smaller for asymmetric than for symmetric synapses in all cortical layers. In all cases, synaptic junction sizes followed a log-normal distribution. Secondly, most cortical synapses had disc-shaped postsynaptic densities (PSDs; 93%). A few were perforated (4.5%), while a smaller proportion (2.5%) showed a tortuous horseshoe-shaped perimeter. Thirdly, the curvature was larger for symmetric than for asymmetric synapses in all layers. However, there was no correlation between synaptic area and curvature. PMID:29387782

Study of the Size and Shape of Synapses in the Juvenile Rat Somatosensory Cortex with 3D Electron Microscopy.

PubMed

Santuy, Andrea; Rodríguez, José-Rodrigo; DeFelipe, Javier; Merchán-Pérez, Angel

2018-01-01

Changes in the size of the synaptic junction are thought to have significant functional consequences. We used focused ion beam milling and scanning electron microscopy (FIB/SEM) to obtain stacks of serial sections from the six layers of the rat somatosensory cortex. We have segmented in 3D a large number of synapses ( n = 6891) to analyze the size and shape of excitatory (asymmetric) and inhibitory (symmetric) synapses, using dedicated software. This study provided three main findings. Firstly, the mean synaptic sizes were smaller for asymmetric than for symmetric synapses in all cortical layers. In all cases, synaptic junction sizes followed a log-normal distribution. Secondly, most cortical synapses had disc-shaped postsynaptic densities (PSDs; 93%). A few were perforated (4.5%), while a smaller proportion (2.5%) showed a tortuous horseshoe-shaped perimeter. Thirdly, the curvature was larger for symmetric than for asymmetric synapses in all layers. However, there was no correlation between synaptic area and curvature.

A Conceptual Framework for Quality of Care

PubMed Central

Mosadeghrad, Ali Mohammad

2012-01-01

Despite extensive research on defining and measuring health care quality, little attention has been given to different stakeholders’ perspectives of high-quality health care services. The main purpose of this study was to explore the attributes of quality healthcare in the Iranian context. Exploratory in-depth individual and focus group interviews were conducted with key healthcare stakeholders including clients, providers, managers, policy makers, payers, suppliers and accreditation panel members to identify the healthcare service quality attributes and dimensions. Data analysis was carried out by content analysis, with the constant comparative method. Over 100 attributes of quality healthcare service were elicited and grouped into five categories. The dimensions were: efficacy, effectiveness, efficiency, empathy, and environment. Consequently, a comprehensive model of service quality was developed for health care context. The findings of the current study led to a conceptual framework of healthcare quality. This model leads to a better understanding of the different aspects of quality in health care and provides a better basis for defining, measuring and controlling quality of health care services. PMID:23922534

Single-polymer dynamics under constraints: scaling theory and computer experiment.

PubMed

Milchev, Andrey

2011-03-16

The relaxation, diffusion and translocation dynamics of single linear polymer chains in confinement is briefly reviewed with emphasis on the comparison between theoretical scaling predictions and observations from experiment or, most frequently, from computer simulations. Besides cylindrical, spherical and slit-like constraints, related problems such as the chain dynamics in a random medium and the translocation dynamics through a nanopore are also considered. Another particular kind of confinement is imposed by polymer adsorption on attractive surfaces or selective interfaces--a short overview of single-chain dynamics is also contained in this survey. While both theory and numerical experiments consider predominantly coarse-grained models of self-avoiding linear chain molecules with typically Rouse dynamics, we also note some recent studies which examine the impact of hydrodynamic interactions on polymer dynamics in confinement. In all of the aforementioned cases we focus mainly on the consequences of imposed geometric restrictions on single-chain dynamics and try to check our degree of understanding by assessing the agreement between theoretical predictions and observations.

CHALLENGES AND BENEFITS OF CONDUCTING ENVIRONMENTAL JUSTICE RESEARCH IN A SCHOOL SETTING

PubMed Central

GUIDRY, VIRGINIA T.; LOWMAN, AMY; HALL, DEVON; BARON, DOTHULA; WING, STEVE

2015-01-01

Environmental justice (EJ) research requires attention to consequences for research participants beyond those typically considered by institutional review boards. The imbalance of power between impacted communities and those who create and regulate pollution creates challenges for participation, yet research can also benefit those involved. Our community-academic partnership designed the Rural Air Pollutants and Children's Health (RAPCH) study to provide positive impacts while measuring health effects at three low-resource public middle schools near concentrated animal feeding operations (CAFOs) in North Carolina. We evaluated perceived benefits and challenges of study involvement by interviewing school staff and community liaisons who facilitated data collection. Reported benefits included enhancement of students’ academic environment and increased community environmental awareness; challenges were associated mainly with some participants’ immaturity. Leadership from a strong community-based organization was crucial to recruitment, yet our approach entailed minimal focus on EJ, which may have limited opportunities for community education or organizing for environmental health. PMID:25085828

Developmental reprogramming by UV-B radiation in plants.

PubMed

Dotto, Marcela; Casati, Paula

2017-11-01

Plants are extremely plastic organisms with the ability to adapt and respond to the changing environmental conditions surrounding them. Sunlight is one of the main resources for plants, both as a primary energy source for photosynthesis and as a stimulus that regulates different aspects of their growth and development. UV-B comprises wavelengths that correspond to a high energy region of the solar spectrum capable of reaching the biosphere, influencing plant growth. It is currently believed that plants are able to acclimate when growing under the influence of this radiation and perceive it as a signal, without stress signs. Nonetheless, many UV-B induced changes are elicited after DNA damage occurs as a consequence of exposure. In this review we focus on the influence of UV-B on leaf, flower and root development and emphasize the limited understanding of the molecular mechanisms for most of this developmental processes affected by UV-B documented over the years of research in this area. Copyright © 2017 Elsevier B.V. All rights reserved.

Achieving enhanced organisational resilience by improved management of risk: Summary of research into the principles of resilience and the practices of resilient organisations.

PubMed

Hopkin, Paul

There have been many high-profile incidents in recent times that have affected both individual organisations and large parts of society. In response to these disasters and their consequences, there has been increasing focus on the concept of 'resilience'. Airmic worked with Cranfield School of Management to investigate the features of resilient organisations and whether common characteristics could be identified. The research summarised in this paper discovered five principles that increase an organisation's level of resilence. The paper also reports on the actions taken by organisations to embed these resilience principles into four main business enablers. These business enablers in combination represent the business model of the organisation. The overall conclusion of the research was that, in order to achieve a state of enhanced resilience, organisations need to be aware of risks and threats they face and then combine the actions required to be 'risk compliant' with the ability to be 'risk responsive'.

Burstiness and tie activation strategies in time-varying social networks.

PubMed

Ubaldi, Enrico; Vezzani, Alessandro; Karsai, Márton; Perra, Nicola; Burioni, Raffaella

2017-04-13

The recent developments in the field of social networks shifted the focus from static to dynamical representations, calling for new methods for their analysis and modelling. Observations in real social systems identified two main mechanisms that play a primary role in networks' evolution and influence ongoing spreading processes: the strategies individuals adopt when selecting between new or old social ties, and the bursty nature of the social activity setting the pace of these choices. We introduce a time-varying network model accounting both for ties selection and burstiness and we analytically study its phase diagram. The interplay of the two effects is non trivial and, interestingly, the effects of burstiness might be suppressed in regimes where individuals exhibit a strong preference towards previously activated ties. The results are tested against numerical simulations and compared with two empirical datasets with very good agreement. Consequently, the framework provides a principled method to classify the temporal features of real networks, and thus yields new insights to elucidate the effects of social dynamics on spreading processes.

Exploring anaerobic environments for cyanide and cyano-derivatives microbial degradation.

PubMed

Luque-Almagro, Víctor M; Cabello, Purificación; Sáez, Lara P; Olaya-Abril, Alfonso; Moreno-Vivián, Conrado; Roldán, María Dolores

2018-02-01

Cyanide is one of the most toxic chemicals for living organisms described so far. Its toxicity is mainly based on the high affinity that cyanide presents toward metals, provoking inhibition of essential metalloenzymes. Cyanide and its cyano-derivatives are produced in a large scale by many industrial activities related to recovering of precious metals in mining and jewelry, coke production, steel hardening, synthesis of organic chemicals, and food processing industries. As consequence, cyanide-containing wastes are accumulated in the environment becoming a risk to human health and ecosystems. Cyanide and related compounds, like nitriles and thiocyanate, are degraded aerobically by numerous bacteria, and therefore, biodegradation has been offered as a clean and cheap strategy to deal with these industrial wastes. Anaerobic biological treatments are often preferred options for wastewater biodegradation. However, at present very little is known about anaerobic degradation of these hazardous compounds. This review is focused on microbial degradation of cyanide and related compounds under anaerobiosis, exploring their potential application in bioremediation of industrial cyanide-containing wastes.

Relevance of the land use changes related to a megacity development in a Colombian river basin

NASA Astrophysics Data System (ADS)

García-Arias, Alicia; Romero Hernández, Claudia Patricia; Francés, Félix

2017-04-01

A megacity development is a main driving force for land uses changes. Population in these megacities usually rise depending on some or all of the natural resources related to the occupied area and, among them, water is a pivotal requirement. On the other hand, land use changes determine the catchment hydrology and, in consequence, its management. The better knowledge on land uses cover distribution and characteristics, the higher capabilities to increase the accuracy of hydrological predictions and the efficiency of water management. This study aims to describe the land uses changes occurred during the recent expansion of the megacity of Bogotá (Colombia) and to understand the expected changes. In addition, we propose the base for the consideration of this land use changes in the TETIS distributed hydrological modelling approach. The discussion focus on the necessity of considering this kind of scenarios in hydrological modelling for a responsible management of the water resources.

Combined impacts of global changes on biodiversity across the USA

PubMed Central

Bellard, C.; Leclerc, C.; Courchamp, F.

2015-01-01

Most studies of the effects of global changes on biodiversity focus on a single threat, but multiple threats lead to species extinction. We lack spatially explicit assessments of the intensity of multiple threats and their impacts on biodiversity. Here, we used a novel metric of cumulative threats and impacts to assess the consequences of multiple threats on 196 endemic species across the USA. We predict that large areas with high cumulative impact scores for amphibians, birds, mammals, and reptiles will be concentrated in the eastern part of the USA by the 2050 s and 2080 s. These high cumulative impact values are due mainly to the presence of invasive species, climate change, cropland and pasture areas; additionally, a significant proportion of endemic species are vulnerable to some of these threats where they occur. This analysis provides a useful means of identifying where conservation measures and monitoring programs that should consider multiple threats should be implemented in the future. PMID:26149694

Interactions between tea catechins and casein micelles and their impact on renneting functionality.

PubMed

Haratifar, Sanaz; Corredig, Milena

2014-01-15

Many studies have shown that tea catechins bind to milk proteins. This research focused on the association of tea polyphenols with casein micelles, and the consequences of the interactions on the renneting behaviour of skim milk. It was hypothesized that epigallocatechin-gallate (EGCG), the main catechin present in green tea, forms complexes with the casein micelles and that the association modifies the processing functionality of casein micelles. The binding of EGCG to casein micelles was quantified using HPLC. The formation of catechin-casein micelles complexes affected the rennet induced gelation of milk, and the effect was concentration dependent. Both the primary as well as the secondary stage of gelation were affected. These experiments clearly identify the need for a better understanding of the effect of tea polyphenols on the processing functionality of casein micelles, before milk products can be used as an appropriate platform for delivery of bioactive compounds. Copyright © 2013 Elsevier Ltd. All rights reserved.

Multi-agent Simulations of Population Behavior: A Promising Tool for Systems Biology.

PubMed

Colosimo, Alfredo

2018-01-01

This contribution reports on the simulation of some dynamical events observed in the collective behavior of different kinds of populations, ranging from shape-changing cells in a Petri dish to functionally correlated brain areas in vivo. The unifying methodological approach, based upon a Multi-Agent Simulation (MAS) paradigm as incorporated in the NetLogo™ interpreter, is a direct consequence of the cornerstone that simple, individual actions within a population of interacting agents often give rise to complex, collective behavior.The discussion will mainly focus on the emergence and spreading of synchronous activities within the population, as well as on the modulation of the collective behavior exerted by environmental force-fields. A relevant section of this contribution is dedicated to the extension of the MAS paradigm to Brain Network models. In such a general framework some recent applications taken from the direct experience of the author, and exploring the activation patterns characteristic of specific brain functional states, are described, and their impact on the Systems-Biology universe underlined.

Analytical methods used for the authentication of food of animal origin.

PubMed

Abbas, Ouissam; Zadravec, Manuela; Baeten, Vincent; Mikuš, Tomislav; Lešić, Tina; Vulić, Ana; Prpić, Jelena; Jemeršić, Lorena; Pleadin, Jelka

2018-04-25

Since adulteration can have serious consequences on human health, it affects market growth by destroying consumer confidence. Therefore, authentication of food is important for food processors, retailers and consumers, but also for regulatory authorities. However, a complex nature of food and an increase in types of adulterants make their detection difficult, so that food authentication often poses a challenge. This review focuses on analytical approaches to authentication of food of animal origin, with an emphasis put on determination of specific ingredients, geographical origin and adulteration by virtue of substitution. This review highlights a current overview of the application of target approaches in cases when the compound of interest is known and non-target approaches for screening issues. Papers cited herein mainly concern milk, cheese, meat and honey. Moreover, advantages, disadvantages as well as challenges regarding the use of both approaches in official food control but also in food industry are investigated. Copyright © 2017 Elsevier Ltd. All rights reserved.

Fully automated measuring setup for tactile coordinate measuring machine for three dimensional measurement of freeform eyeglass frames

NASA Astrophysics Data System (ADS)

Rückwardt, M.; Göpfert, A.; Correns, M.; Schellhorn, M.; Linß, G.

2010-07-01

Coordinate measuring machines are high precession all-rounder in three dimensional measuring. Therefore the versatility of parameters and expandability of additionally hardware is very comprehensive. Consequently you need much expert knowledge of the user and mostly a lot of advanced information about the measuring object. In this paper a coordinate measuring machine and a specialized measuring machine are compared at the example of the measuring of eyeglass frames. For this case of three dimensional measuring challenges the main focus is divided into metrological and economical aspects. At first there is shown a fully automated method for tactile measuring of this abstract form. At second there is shown a comparison of the metrological characteristics of a coordinate measuring machine and a tracer for eyeglass frames. The result is in favour to the coordinate measuring machine. It was not surprising in these aspects. At last there is shown a comparison of the machine in front of the economical aspects.

Reinsurance of health insurance for the informal sector.

PubMed Central

Dror, D. M.

2001-01-01

Deficient financing of health services in low-income countries and the absence of universal insurance coverage leaves most of the informal sector in medical indigence, because people cannot assume the financial consequences of illness. The role of communities in solving this problem has been recognized, and many initiatives are under way. However, community financing is rarely structured as health insurance. Communities that pool risks (or offer insurance) have been described as micro-insurance units. The sources of their financial instability and the options for stabilization are explained. Field data from Uganda and the Philippines, as well as simulated situations, are used to examine the arguments. The article focuses on risk transfer from micro-insurance units to reinsurance. The main insight of the study is that when the financial results of micro-insurance units can be estimated, they can enter reinsurance treaties and be stabilized from the first year. The second insight is that the reinsurance pool may require several years of operation before reaching cost neutrality. PMID:11477971

Can IVF influence human evolution?

PubMed

Hanevik, Hans Ivar; Hessen, Dag O; Sunde, Arne; Breivik, Jarle

2016-07-01

IVF, a procedure in which pharmacological and technological manipulation is used to promote pregnancy, offers help to infertile couples by circumventing selection at the most fundamental level. Fertility is clearly one of the key fitness-promoting drivers in all forms of sexually reproducing life, and fertilization and pregnancy are fundamental evolutionary processes that involve a range of pre- and post-zygotic screening mechanisms. Here, we discuss the various selection and screening factors involved in fertilization and pregnancy and assess IVF practices in light of these factors. We then focus on the possible consequences of these differences in selection pressures, mainly at the individual but also at the population level, to evaluate whether changes in the reproducing genotype can affect human evolution. The aim of the article is not to argue for or against IVF, but to address aspects of assisted reproduction in an evolutionary context. © The Author 2016. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Technological trends, global market, and challenges of bio-ethanol production.

PubMed

Mussatto, Solange I; Dragone, Giuliano; Guimarães, Pedro M R; Silva, João Paulo A; Carneiro, Lívia M; Roberto, Inês C; Vicente, António; Domingues, Lucília; Teixeira, José A

2010-01-01

Ethanol use as a fuel additive or directly as a fuel source has grown in popularity due to governmental regulations and in some cases economic incentives based on environmental concerns as well as a desire to reduce oil dependency. As a consequence, several countries are interested in developing their internal market for use of this biofuel. Currently, almost all bio-ethanol is produced from grain or sugarcane. However, as this kind of feedstock is essentially food, other efficient and economically viable technologies for ethanol production have been evaluated. This article reviews some current and promising technologies for ethanol production considering aspects related to the raw materials, processes, and engineered strains development. The main producer and consumer nations and future perspectives for the ethanol market are also presented. Finally, technological trends to expand this market are discussed focusing on promising strategies like the use of microalgae and continuous systems with immobilized cells. Copyright © 2010 Elsevier Inc. All rights reserved.

Burstiness and tie activation strategies in time-varying social networks

NASA Astrophysics Data System (ADS)

Ubaldi, Enrico; Vezzani, Alessandro; Karsai, Márton; Perra, Nicola; Burioni, Raffaella

2017-04-01

The recent developments in the field of social networks shifted the focus from static to dynamical representations, calling for new methods for their analysis and modelling. Observations in real social systems identified two main mechanisms that play a primary role in networks’ evolution and influence ongoing spreading processes: the strategies individuals adopt when selecting between new or old social ties, and the bursty nature of the social activity setting the pace of these choices. We introduce a time-varying network model accounting both for ties selection and burstiness and we analytically study its phase diagram. The interplay of the two effects is non trivial and, interestingly, the effects of burstiness might be suppressed in regimes where individuals exhibit a strong preference towards previously activated ties. The results are tested against numerical simulations and compared with two empirical datasets with very good agreement. Consequently, the framework provides a principled method to classify the temporal features of real networks, and thus yields new insights to elucidate the effects of social dynamics on spreading processes.

Quality of Sleep Among Intensive Care Unit Patients: A Literature Review.

PubMed

Bani Younis, Mohammad; Hayajneh, Ferial A

Investigating sleep disturbances among intensive care unit (ICU) patients and its serious consequences is considered a crucial issue for nurses. The need of sleep increases during hospitalization time to preserve energy for the healing process. Previous studies have demonstrated that sleep disturbance is one of the most common complaints of patients in the ICUs, with a prevalence of more than 50%. Although the total sleep time might be normal, the patients' sleep is fragmented and light in the intensive care settings. The main purpose of this review is to generate a clear view of what is known about sleep disturbances among ICU patients as well as to identify the gap in knowledge regarding this issue. This was done by describing, summarizing, clarifying, and evaluating well-selected previous studies about this topic. In addition, this concise review has focused on the prevalence of sleep disturbances in the ICU, factors contributing to poor quality of sleep among ICU patients, and the physiological effects of poor sleep on the patients' prognosis.

Biology of diesel exhaust effects on respiratory function.

PubMed

Riedl, Marc; Diaz-Sanchez, David

2005-02-01

In recent decades, clinicians and scientists have witnessed a significant increase in the prevalence of allergic rhinitis and asthma. The factors underlying this phenomenon are clearly complex; however, this rapid increase in the burden of atopic disease has undeniably occurred in parallel with rapid industrialization and urbanization in many parts of the world. Consequently, more people are exposed to air pollutants than at any point in human history. Worldwide, increases in allergic respiratory disease have mainly been observed in urban communities. Epidemiologic and clinical investigations have suggested a strong link between particulate air pollution and detrimental health effects, including cardiopulmonary morbidity and mortality. The purpose of this review is to provide an evidence-based summary of the health effects of air pollutants on asthma, focusing on diesel exhaust particles (DEPs) as a model particulate air pollutant. An overview of observational and experimental studies linking DEPs and asthma will be provided, followed by consideration of the mechanisms underlying DEP-induced inflammation and a brief discussion of future research and clinical directions.

Magnitude and pattern of Arctic warming governed by the seasonality of radiative forcing.

PubMed

Bintanja, R; Krikken, F

2016-12-02

Observed and projected climate warming is strongest in the Arctic regions, peaking in autumn/winter. Attempts to explain this feature have focused primarily on identifying the associated climate feedbacks, particularly the ice-albedo and lapse-rate feedbacks. Here we use a state-of-the-art global climate model in idealized seasonal forcing simulations to show that Arctic warming (especially in winter) and sea ice decline are particularly sensitive to radiative forcing in spring, during which the energy is effectively 'absorbed' by the ocean (through sea ice melt and ocean warming, amplified by the ice-albedo feedback) and consequently released to the lower atmosphere in autumn and winter, mainly along the sea ice periphery. In contrast, winter radiative forcing causes a more uniform response centered over the Arctic Ocean. This finding suggests that intermodel differences in simulated Arctic (winter) warming can to a considerable degree be attributed to model uncertainties in Arctic radiative fluxes, which peak in summer.

Speckle size in optical Fourier domain imaging

NASA Astrophysics Data System (ADS)

Lamouche, G.; Vergnole, S.; Bisaillon, C.-E.; Dufour, M.; Maciejko, R.; Monchalin, J.-P.

2007-06-01

As in conventional time-domain optical coherence tomography (OCT), speckle is inherent to any Optical Fourier Domain Imaging (OFDI) of biological tissue. OFDI is also known as swept-source OCT (SS-OCT). The axial speckle size is mainly determined by the OCT resolution length and the transverse speckle size by the focusing optics illuminating the sample. There is also a contribution from the sample related to the number of scatterers contained within the probed volume. In the OFDI data processing, there is some liberty in selecting the range of wavelengths used and this allows variation in the OCT resolution length. Consequently the probed volume can be varied. By performing measurements on an optical phantom with a controlled density of discrete scatterers and by changing the probed volume with different range of wavelengths in the OFDI data processing, there is an obvious change in the axial speckle size, but we show that there is also a less obvious variation in the transverse speckle size. This work contributes to a better understanding of speckle in OCT.

Lipid nanoparticles as novel delivery systems for cosmetics and dermal pharmaceuticals.

PubMed

Puglia, Carmelo; Bonina, Francesco

2012-04-01

Lipid nanoparticles are innovative carrier systems developed as an alternative to traditional vehicles such as emulsions, liposomes and polymeric nanoparticles. Solid lipid nanoparticles (SLN) and the newest nanostructured lipid carriers (NLC) show important advantages for dermal application of cosmetics and pharmaceuticals. This article focuses on the main features of lipid nanoparticles, in terms of their preparation and recent advancements. A detailed review of the literature is presented, introducing the importance of these systems in the topical delivery of drugs and active substances. Lipid nanoparticles are able to enhance drug penetration into the skin, allowing increased targeting to the epidermis and consequently increasing treatment efficiency and reducing the systemic absorption of drugs and cosmetic actives. The complete biodegradation of lipid nanoparticles and their biocompatible chemical nature have secured them the title of 'nanosafe carriers.' SLN and NLC represent a new technological era, which has been taken over by the cosmetic and pharmaceutical industry, which will open new channels for effective topical delivery of substances.

Exploring the Use of Molecular Biomarkers for Precision Medicine in Age-Related Macular Degeneration.

PubMed

Lorés-Motta, Laura; de Jong, Eiko K; den Hollander, Anneke I

2018-06-01

Precision medicine aims to improve patient care by adjusting medication to each patient's individual needs. Age-related macular degeneration (AMD) is a heterogeneous eye disease in which several pathways are involved, and the risk factors driving the disease differ per patient. As a consequence, precision medicine holds promise for improved management of this disease, which is nowadays a main cause of vision loss in the elderly. In this review, we provide an overview of the studies that have evaluated the use of molecular biomarkers to predict response to treatment in AMD. We predominantly focus on genetic biomarkers, but also include studies that examined circulating or eye fluid biomarkers in treatment response. This involves studies on treatment response to dietary supplements, response to anti-vascular endothelial growth factor, and response to complement inhibitors. In addition, we highlight promising new therapies that have been or are currently being tested in clinical trials and discuss the molecular studies that can help identify the most suitable patients for these upcoming therapeutic approaches.

Methodologies and Perspectives of Proteomics Applied to Filamentous Fungi: From Sample Preparation to Secretome Analysis

PubMed Central

Bianco, Linda; Perrotta, Gaetano

2015-01-01

Filamentous fungi possess the extraordinary ability to digest complex biomasses and mineralize numerous xenobiotics, as consequence of their aptitude to sensing the environment and regulating their intra and extra cellular proteins, producing drastic changes in proteome and secretome composition. Recent advancement in proteomic technologies offers an exciting opportunity to reveal the fluctuations of fungal proteins and enzymes, responsible for their metabolic adaptation to a large variety of environmental conditions. Here, an overview of the most commonly used proteomic strategies will be provided; this paper will range from sample preparation to gel-free and gel-based proteomics, discussing pros and cons of each mentioned state-of-the-art technique. The main focus will be kept on filamentous fungi. Due to the biotechnological relevance of lignocellulose degrading fungi, special attention will be finally given to their extracellular proteome, or secretome. Secreted proteins and enzymes will be discussed in relation to their involvement in bio-based processes, such as biomass deconstruction and mycoremediation. PMID:25775160

Methodologies and perspectives of proteomics applied to filamentous fungi: from sample preparation to secretome analysis.

PubMed

Bianco, Linda; Perrotta, Gaetano

2015-03-12

Filamentous fungi possess the extraordinary ability to digest complex biomasses and mineralize numerous xenobiotics, as consequence of their aptitude to sensing the environment and regulating their intra and extra cellular proteins, producing drastic changes in proteome and secretome composition. Recent advancement in proteomic technologies offers an exciting opportunity to reveal the fluctuations of fungal proteins and enzymes, responsible for their metabolic adaptation to a large variety of environmental conditions. Here, an overview of the most commonly used proteomic strategies will be provided; this paper will range from sample preparation to gel-free and gel-based proteomics, discussing pros and cons of each mentioned state-of-the-art technique. The main focus will be kept on filamentous fungi. Due to the biotechnological relevance of lignocellulose degrading fungi, special attention will be finally given to their extracellular proteome, or secretome. Secreted proteins and enzymes will be discussed in relation to their involvement in bio-based processes, such as biomass deconstruction and mycoremediation.

Genotoxicity Studies Performed in the Ecuadorian Population

PubMed Central

Paz-y-Miño, César; Cumbal, Nadia; Sánchez, María Eugenia

2012-01-01

Genotoxicity studies in Ecuador have been carried out during the past two decades. The focuses of the research were mainly the area of environmental issues, where the populations have been accidentally exposed to contaminants and the area of occupational exposure of individuals at the workplace. This paper includes studies carried out in the population of the Amazon region, a zone known for its rich biodiversity as well as for the ecological damage caused by oil spills and chemical sprayings whose consequences continue to be controversial. Additionally, we show the results of studies comprised of individuals occupationally exposed to toxic agents in two very different settings: flower plantation workers exposed to pesticide mixtures and X-ray exposure of hospital workers. The results from these studies confirm that genotoxicity studies can help evaluate current conditions and prevent further damage in the populations exposed to contaminants. As such, they are evidence of the need for biomonitoring employers at risk, stricter law enforcement regarding the use of pesticides, and increasingly conscientious oil extraction activities. PMID:22496977

Multidimensional upwind hydrodynamics on unstructured meshes using graphics processing units - I. Two-dimensional uniform meshes

NASA Astrophysics Data System (ADS)

Paardekooper, S.-J.

2017-08-01

We present a new method for numerical hydrodynamics which uses a multidimensional generalization of the Roe solver and operates on an unstructured triangular mesh. The main advantage over traditional methods based on Riemann solvers, which commonly use one-dimensional flux estimates as building blocks for a multidimensional integration, is its inherently multidimensional nature, and as a consequence its ability to recognize multidimensional stationary states that are not hydrostatic. A second novelty is the focus on graphics processing units (GPUs). By tailoring the algorithms specifically to GPUs, we are able to get speedups of 100-250 compared to a desktop machine. We compare the multidimensional upwind scheme to a traditional, dimensionally split implementation of the Roe solver on several test problems, and we find that the new method significantly outperforms the Roe solver in almost all cases. This comes with increased computational costs per time-step, which makes the new method approximately a factor of 2 slower than a dimensionally split scheme acting on a structured grid.

[Mobbing: a meta-analysis and integrative model of its antecedents and consequences].

PubMed

Topa Cantisano, Gabriela; Depolo, Marco; Morales Domínguez, J Francisco

2007-02-01

Although mobbing has been extensively studied, empirical research has not led to firm conclusions regarding its antecedents and consequences, both at personal and organizational levels. An extensive literature search yielded 86 empirical studies with 93 samples. The matrix correlation obtained through meta-analytic techniques was used to test a structural equation model. Results supported hypotheses regarding organizational environmental factors as main predictors of mobbing.

Needs, expectations and consequences for children growing up in a family where the parent has a mental illness.

PubMed

Tabak, Izabela; Zabłocka-Żytka, Lidia; Ryan, Peter; Poma, Stefano Zanone; Joronen, Katja; Viganò, Giovanni; Simpson, Wendy; Paavilainen, Eija; Scherbaum, Norbert; Smith, Martin; Dawson, Ian

2016-08-01

The lack of pan-European guidelines for empowering children of parents with mental illness led to the EU project CAMILLE - Empowerment of Children and Adolescents of Mentally Ill Parents through Training of Professionals working with children and adolescents. The aim of this initial task in the project was to analyse needs, expectations and consequences for children with respect to living with a parent with mental illness from the perspective of professionals and family members. This qualitative research was conducted in England, Finland, Germany, Italy, Norway, Poland and Scotland with 96 professionals, parents with mental illness, adult children and partners of parents with mental illness. A framework analysis method was used. Results of the study highlighted that the main consequences described for children of parental mental illness were role reversal; emotional and behavioural problems; lack of parent's attention and stigma. The main needs of these children were described as emotional support, security and multidisciplinary help. Implications for practice are that professionals working with parents with mental illness should be aware of the specific consequences for the children and encourage parents in their parental role; multi-agency collaboration is necessary; schools should provide counselling and prevent stigma. © 2016 Australian College of Mental Health Nurses Inc.

Dual Standards of School Performance and Funding? Empirical Searches of School Funding Adequacy in Kentucky and Maine

ERIC Educational Resources Information Center

Lee, Jaekyung

2010-01-01

This study examines potential consequences of the discrepancies between national and state performance standards for school funding in Kentucky and Maine. Applying the successful schools observation method and cost function analysis method to integrated data-sets that match schools' eight-grade mathematics test performance measures to district…

Cultural consequences of miscarriages of justice.

PubMed

Cole, Simon A

2009-01-01

Social science scholarship has tended to focus more on the causes than the consequences of miscarriages of justice. Within the literature on consequences, the overwhelming emphasis has been on individual consequences: psychological and material impacts on the wrongly convicted individual and, in some cases, other indirectly impacted individuals such as family members of the wrongly convicted and victims of the true perpetrator's future crimes. Some attention has been devoted to social harms, the impact of miscarriages of justice on the broader society within which they are situated, such as the undermining of the legitimacy of the criminal justice system. This paper focuses on what are called here cultural consequences of miscarriages of justice: the way in which some high-profile miscarriages of justice can shape the public's beliefs about some of the most basic "facts" about crime, such as the nature, prevalence, or even existence of certain categories of crime and the types of individual who tend to perpetrate particular types of crime. In this way, the paper argues, miscarriages of justice may have hitherto underexplored consequences: reshaping, based on false premises, the public's belief about the very nature of crime itself. This paper discusses three cases studies of miscarriages of justice that for varying periods of time created widespread false beliefs about the nature of crime in large segments of the public. The paper concludes by noting that the "righting" of these false beliefs was in most cases fortuitous. This suggests that unexposed miscarriages of justice may still be shaping popular beliefs about the nature of crime, and aspects of the public's current conception of crime may yet be based on false premises. (c) 2009 John Wiley & Sons, Ltd.

Unintended consequences: the social context of cancer survivors and work.

PubMed

Mak, Angela Ka Ying; Chaidaroon, Suwichit; Fan, Gilbert; Thalib, Fahimah

2014-06-01

This article describes the ways in which socioeconomic characteristics and workplace contexts shape the unintended consequences that cancer survivors can experience as they return to work. The study was conducted in an employment setting where there is a major focus on productivity and economic growth in the business sector. Five focus groups (N = 33 participants) were conducted in 2012 in Singapore. Questions were directed at obtaining information related to the meaning of a job and reactions to return to work as a cancer survivor completes primary cancer treatment. A thematic analysis using a two-staged analytical process was conducted to identify (1) work-related challenges faced by survivors as a result of the interplay between their self-identity as someone with a critical illness and organizational structure, and (2) unintended social consequences (USCs) related to the interaction between the workplace and cancer survivor. Eight emerging themes of work-related challenges and unintended consequences were categorized. Fear of losing out by compromising one's expectation, downplaying illness to avoid being a burden to others, working harder to meet expectations, and passive acceptance to perceived discrimination. Unintended consequences were also observed in relation to policies, procedures, and economic factors in the context of a heightened economically driven social climate. This study contributes to the understanding of how cancer survivors perceive their work situation. These findings can inform health care providers, employers, and policy makers regarding the challenges faced by cancer survivors as they return to the workplace in a culture of a rapidly growing emphasis on economic concerns. These findings offer a new perspective on the complexities that can occur when cancer survivors interact with their workplace. Awareness of the existence and types of unintended consequences in this context can help provide a more comprehensive understanding of the cancer survivor and work interface.

Psychosocial Risk Factors, Interventions, and Comorbidity in Patients with Non-Specific Low Back Pain in Primary Care: Need for Comprehensive and Patient-Centered Care

PubMed Central

Ramond-Roquin, Aline; Bouton, Céline; Bègue, Cyril; Petit, Audrey; Roquelaure, Yves; Huez, Jean-François

2015-01-01

Non-specific low back pain (LBP) affects many people and has major socio-economic consequences. Traditional therapeutic strategies, mainly focused on biomechanical factors, have had moderate and short-term impact. Certain psychosocial factors have been linked to poor prognosis of LBP and they are increasingly considered as promising targets for management of LBP. Primary health care providers (HCPs) are involved in most of the management of people with LBP and they are skilled in providing comprehensive care, including consideration of psychosocial dimensions. This review aims to discuss three pieces of recent research focusing on psychosocial issues in LBP patients in primary care. In the first systematic review, the patients’ or HCPs’ overall judgment about the likely evolution of LBP was the factor most strongly linked to poor outcome, with predictive validity similar to that of multidimensional scales. This result may be explained by the implicit aggregation of many prognostic factors underlying this judgment and suggests the relevance of considering the patients from biopsychosocial and longitudinal points of view. The second review showed that most of the interventions targeting psychosocial factors in LBP in primary care have to date focused on the cognitive-behavioral factors, resulting in little impact. It is unlikely that any intervention focusing on a single factor would ever fit the needs of most patients; interventions targeting determinants from several fields (mainly psychosocial, biomechanical, and occupational) may be more relevant. Should multiple stakeholders be involved in such interventions, enhanced interprofessional collaboration would be critical to ensure the delivery of coordinated care. Finally, in the third study, the prevalence of psychosocial comorbidity in chronic LBP patients was not found to be significantly higher than in other patients consulting in primary care. Rather than specifically screening for psychosocial conditions, this suggests taking into account any potential comorbidity in patients with chronic LBP, as in other patients. All these results support the adoption of a more comprehensive and patient-centered approach when dealing with patients with LBP in primary care. As this condition is illustrative of many situations encountered in primary care, the strategies proposed here may benefit most patients consulting in this setting. PMID:26501062

Does public reporting influence quality, patient and provider's perspective, market share and disparities? A review.

PubMed

Vukovic, Vladimir; Parente, Paolo; Campanella, Paolo; Sulejmani, Adela; Ricciardi, Walter; Specchia, Maria Lucia

2017-12-01

Public reporting (PR) of healthcare (HC) provider's quality was proposed as a public health instrument for providing transparency and accountability in HC. Our aim was to assess the impact of PR on five main domains: quality improvement; patient choice, service utilization and market share; provider's perspective; patient experience; and unintended consequences. PubMed, Scopus, ISI WOS, and EconLit databases were searched to identify studies investigating relationships between PR and five main domains, published up to April 1, 2016. Sixty-two papers published between 1988 and 2015 were included. Nineteen studies investigated quality improvement, 19 studies explored the unintended consequences of PR, 10 explored the effects on market share, 10 on patients' choice, 7 evaluated the provider's perspective, 4 economic outcome, 4 service utilization, 2 purchasers' use of PR and 2 studies explored patient experiences. The effect of PR was diverse throughout the studies-mostly positive on: patient experience (100%), quality improvement (63%), patient choice, service utilization and market share (46%); mixed on provider's perspective and economic outcome (27%) and mainly negative on unintended consequences (68%). Our research covering different outcomes and settings reported that PR is associated with changes in HC provider's behavior and can influence market share. Unintended consequences are a concern of PR and should be taken into account when allocating HC resources. The experiences collected in this paper could give a snapshot about the impact of PR on a HC user's perception of the providers' quality of care, helping them to make empowered choices. © The Author 2017. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.

Health Consequences of Drug Misuse

MedlinePlus

Skip to main content En español Researchers Medical & Health Professionals Patients & ... Medicines Prescription Medicines Steroids (Anabolic) Synthetic Cannabinoids (K2/Spice) Synthetic Cathinones (Bath Salts) Tobacco/Nicotine ...

The dot{M}-M_* relation of pre-main-sequence stars: a consequence of X-ray driven disc evolution

NASA Astrophysics Data System (ADS)

Ercolano, B.; Mayr, D.; Owen, J. E.; Rosotti, G.; Manara, C. F.

2014-03-01

We analyse current measurements of accretion rates on to pre-main-sequence stars as a function of stellar mass, and conclude that the steep dependence of accretion rates on stellar mass is real and not driven by selection/detection threshold, as has been previously feared. These conclusions are reached by means of statistical tests including a survival analysis which can account for upper limits. The power-law slope of the dot{M}-M_* relation is found to be in the range of 1.6-1.9 for young stars with masses lower than 1 M⊙. The measured slopes and distributions can be easily reproduced by means of a simple disc model which includes viscous accretion and X-ray photoevaporation. We conclude that the dot{M}-M_* relation in pre-main-sequence stars bears the signature of disc dispersal by X-ray photoevaporation, suggesting that the relation is a straightforward consequence of disc physics rather than an imprint of initial conditions.

Bullying during adolescence in Brazil: an overview.

PubMed

Pigozi, Pamela Lamarca; Machado, Ana Lúcia

2015-11-01

Bullying has been the subject of worldwide study for over four decades and is widely reported by social media. Despite this, the issue is a relatively new area of research in Brazil. This study analyzes academic literature addressing bullying produced in Brazil focusing on aspects that characterize this issue as a subtype of violence: gender differences, factors associated with bullying, consequences, and possible intervention and prevention approaches. The guiding question of this study was: what have Brazilian researchers produced regarding bullying among adolescents? The results show that over half of the studies used quantitative approaches, principally cross-sectional methods and questionnaires, and focused on determining the prevalence of and factors associated with bullying. The findings showed a high prevalence of bullying among Brazilian adolescents, an association between risk behavior and bullying, serious consequences for the mental health of young people, lack of awareness and understanding among adolescents about bullying and its consequences, and a lack of strategies to manage this type of aggression. There is a need for intervention studies, prevention and restorative practices that involve the community and can be applied to everyday life at school.

Psychological Aspects of Contraception, Unintended Pregnancy, and Abortion.

PubMed

Steinberg, Julia R; Rubin, Lisa R

2014-10-01

The knowledge of important biopsychosocial factors linking women's reproductive health and mental health is increasing. This review focuses on psychological aspects of contraception, unintended pregnancy, and abortion because these are common reproductive health experiences in U.S. women's lives. This review addresses the mental-health antecedents and consequences of these experiences, mostly focusing on depression and depressive symptoms before and after unintended pregnancy and contraception. As mental-health antecedents, depressive symptoms predict contraceptive behaviors that lead to unintended pregnancy, and mental-health disorders have been associated with having subsequent abortions. In examining the mental-health consequences, most sound research does not find abortion or contraceptive use to cause mental-health problems. Consequently, evidence does not support policies based on the notion that abortion harms women's mental health. Nevertheless, the abortion-care setting may be a place to integrate mental-health services. In contrast, women who have births resulting from unintended pregnancies may be at higher risk of postpartum depression. Social policies (e.g., paid maternity leave, subsidized child care) may protect women from mental-health problems and stress of unplanned children interrupting employment, education, and pre-existing family care responsibilities.

"That part of the body is just gone": understanding and responding to dissociation and physical health.

PubMed

Haven, Terri J

2009-01-01

The past 2 decades have brought a significant surge in interest and research regarding the ways in which psychological trauma relates to the physical body. Researchers now understand a great deal about how the brain and the body process traumatic experiences, as well as the increased likelihood of an array of physical health consequences associated with both childhood and adult trauma and posttraumatic stress disorder. Experts are increasingly challenging mind-body dualism through solid theoretical and clinical bases for the central importance of listening to and communicating with trauma clients' bodies as part of reducing the suffering and long-lasting consequences of trauma. This article integrates this growing body of knowledge through a particular focus on trauma-induced dissociation and the implications of the physical and neurological processes and consequences of dissociation on clients' ability to participate in caring for their own bodies. The author utilizes an in-depth clinical example of expanding relational trauma psychotherapy to include a focus on working directly with trauma-related sensorimotor and physiological sensations and patterns.

A Delphi Study Using Value-Focused Thinking for United States Air Force Mission Dependency Index Values

DTIC Science & Technology

2015-03-26

sections will address each method in further detail. Risk-Based Investment Trade-Off Approach Taillandier, Sauce , and Bonetto (2009) followed a...the model to help predict the consequence amount. 19 Figure 9. Decision Model to Produce a Consequence Domain (Taillandier, Sauce ...Taillandier, Sauce , & Bonetto, 2009:789). If these challenges are addressed correctly, this methodology could be applied to the Air Force’s asset portfolio

Proceedings of the DICE THROW Symposium 21-23 June 1977. Volume 2

DTIC Science & Technology

1977-07-01

structure between 2.7 km and 4.3 km MSL that could cause distant blast focusing. Detailed acoustic ray calculations showed a caustic ring about 10 km...depending on just wheie the focus or caustic wave might strike. Propagation toward Truth or Consequences, MM, shown by Figure 14, was slightly ducted...layer. Thus there probably was no focus or caustic that struck any part of that small town. The recorded signal with 370-Pa amplitude was noisy

Robots and people with dementia: Unintended consequences and moral hazard.

PubMed

O'Brolcháin, Fiachra

2017-01-01

The use of social robots in elder care is entering the mainstream as robots become more sophisticated and populations age. While there are many potential benefits to the use of social robots in care for the older people, there are ethical challenges as well. This article focuses on the societal consequences of the adoption of social robots in care for people with dementia. Making extensive use of Alasdair MacIntyre's Dependent Rational Animals to discuss issues of unintended consequences and moral hazard, we contend that in choosing to avoid the vulnerability and dependency of human existence, a society blinds itself from the animal reality of humankind. The consequence of this is that a flourishing society, in which each individual is helped to develop the virtues essential to her flourishing, becomes harder to achieve.

The Impact of Parental Modeling and Permissibility on Alcohol Use and Experienced Negative Drinking Consequences in College

PubMed Central

Abar, Caitlin; Abar, Beau; Turrisi, Rob

2009-01-01

This study examined the impact of parental modeled behavior and permissibility of alcohol use in late high school on the alcohol use and experienced negative drinking consequences of college students. Two-hundred ninety college freshmen at a large university were assessed for perceptions of their parents’ permissibility of alcohol use, parents’ alcohol-related behavior, and own experienced negative consequences associated with alcohol use. Results indicate that parental permissibility of alcohol use is a consistent predictor of teen drinking behaviors, which was strongly associated with experienced negative consequences. Parental modeled use of alcohol was also found to be a risk factor, with significant differences being seen across the gender of the parents and teens. Discussion focuses on risk factors and avenues for prevention research. PMID:19398278

Ecological impacts of energy-wood harvests: lessons from whole-tree harvesting and natural disturbance

Treesearch

Alaina L. Berger; Brian Palik; Anthony W. D' Amato; Shawn Fraver; John B. Bradford; Keith Nislow; David King; Robert T. Brooks

2013-01-01

Recent interest in using forest residues and small-diameter material for biofuels is generating a renewed focus on harvesting impacts and forest sustainability. The rich legacy of research from whole-tree harvesting studies can be examined in light of this interest. Although this research largely focused on consequences for forest productivity, in particular carbon and...

Summary of States' Strategies and Consequences for ESEA Focus Schools. Solutions. Issue No. 2

ERIC Educational Resources Information Center

Perlman, Carole

2013-01-01

As of January 1, 2013, 34 states and the District of Columbia have been granted waivers from certain provisions of the Elementary and Secondary Education Act (ESEA). Part of each successful flexibility application was a state accountability system that could identify priority schools (the lowest performing 5% of Title 1 schools) and focus schools…

Summary of States' Strategies and Consequences for ESEA Focus Schools. Solutions. Issue Number 2

ERIC Educational Resources Information Center

Perlman, Carole

2013-01-01

As of January 1, 2013, 34 states and the District of Columbia have been granted waivers from certain provisions of the Elementary and Secondary Education Act (ESEA). Part of each successful flexibility application was a state accountability system that could identify priority schools (the lowest performing 5% of Title 1 schools) and focus schools…

Developing Caring Relationships in Schools: A Review of the Research on Caring and Nurturing Pedagogies

ERIC Educational Resources Information Center

Velasquez, Andrea; West, Richard; Graham, Charles; Osguthorpe, Richard

2013-01-01

Education has been criticized for a disproportionate focus on the technical aspects of teaching with less focus on its "human" aspects. Consequently, many researchers and theorists have expressed a need to answer what role care plays in education. Our purpose in this review is to examine the definition of caring pedagogies and synthesize…

Examining the Response Process of Fifth Grade Students during Social Studies Instruction

ERIC Educational Resources Information Center

Kay, Victoria

2011-01-01

Over the last decade there has been an increased focus on high-stakes standardized tests in reading and math. Social studies has been devalued in the classroom as many teachers and administrators focus their attention on reading and math instruction to avoid the punitive consequences of the No Child Left Behind Act. (2001). Based on this…

Removing or Controlling? How Caries Management Impacts on the Lifetime of Teeth.

PubMed

Schwendicke, Falk; Lamont, Thomas; Innes, Nicola

2018-05-24

Historically, traditional carious lesion management focused on the importance of removal of all carious tissue, with little thought to the lesion origins. The surgical removal of any sign of a carious lesion was prioritised with little, or no, consideration to pulp vitality, loss of tooth structure, or caries disease management. This symptomatic approach concentrating on lesions rather than on the cause of the disease, focused on preventing secondary carious lesion development. Early detection and improved understanding of the caries process - that lesion progress can be arrested or slowed - has led to preventive measures and less destructive management as a focus. The choice of lesion management depends on: whether a primary or permanent tooth is involved; which tooth surface(s) is/are involved; whether the lesion is confined to enamel or extends into dentine; the lesion depth, and lesion cleansability. Use of preventive and minimally invasive operative strategies is complicated by the lack of predictable ways of recording lesions' status to allow early detection of failed strategies and early intervention. Because re-restoration usually makes the cavity larger and, consequently, the tooth weaker, the clinician should be certain about initiating the repeat restoration cycle, delaying the first restoration as much as possible. The 3 main principles that support preventing or slowing the repeat restoration cycle are: (1) avoid restoration placement until there is no other option; (2) place them for maximum longevity; (3) if re-restoration is necessary, repair or refurbishment is preferable to replacement of a defective restoration. © 2018 S. Karger AG, Basel.

Fluid circulation and structural system of Cerritos Colorados geothermal field in La Primavera volcanic caldera (Mexico) inferred from geophysical surveys

NASA Astrophysics Data System (ADS)

Bolós, X.; Cifuentes-Nava, G.; Macias, J. L.; Sosa-Ceballos, G.; García-Tenorio, F.; Albor, M., III; Juarez, M.; Gamez, V.

2017-12-01

Hydrothermal activity in volcanic calderas is the consequence of energy transfer between deep magmatic chambers and subsurface layers saturated in water. This hydrothermal system is generated by convection of the groundwater supplied by meteoric water recharged and the ascent of hot volcanic gasses exsolved from deep magma reservoirs. Calderas are heterogeneous geological structures that due to their formation and evolution produced a complex stratigraphy. All of these heterogeneities can be affected by deformation and also by the presence of fractures and faults which constitute the main pathways whereby hydrothermal fluids can move easily through the surface as spring discharges and fumarolic activity. Geophysical methods have been used in the last decades to investigate the relationship between structural geology and hydrothermal systems in different volcanic areas around the world. In this work, we have focused on the role of subsurface structures to understand and localize the pathways of fluids related to the hydrothermal system of the Cerritos Colorados geothermal field. We focused in the central area of the caldera (P12 well and Cerritos Colorados graben), where active hydrothermal activity is evidenced by fumaroles, thermal anomalies, CO2 diffuse emission, and sulfur precipitation. We have applied a self-potential method (SP) that combined with temperature measurements that allowed to identify the main infiltration and ascending fluid zones in the area, and their specific surface temperature coinciding with fumarolic activity. From this data we an applied Electrical Resistivity Tomography (ERT) survey in two selected places. One ERT profile (1.2 km in length) was located in the P12 well area. A 3D resistivity model used with the equatorial method was carried out on the Cerritos Colorados graben area. Combining the results of the SP, TºC, and ERT data with a detailed structural map we identified the main degassing zones (i.e. fumaroles) that correspond to higher permeability zones located along normal and strike-slip faults. In conclusion, a strong structural control of the surface manifestation of these hydrothermal systems is deduced from our new data. Then, our results emphasize the importance of old structural boundaries that are controlled by intra-caldera tectonic structures.

Consequences of Arizona's immigration policy on social capital among Mexican mothers with unauthorized immigration status

PubMed Central

Valdez, Carmen R.; Padilla, Brian; Valentine, Jessa Lewis

2013-01-01

This study explores the consequences of increasingly restrictive immigration policies on social capital among Mexican mothers with unauthorized immigrant status in Arizona. Three focus groups conducted in Arizona explore how mothers’ experiences with immigration policies have affected their neighborhood, community, and family ties. Focus group content and interactions revealed that perceived racial profiling was common among mothers and led to fear of family separation. Several described direct experiences with detention and deportation. Although detention and deportation strengthened social ties between mothers and other unauthorized immigrants, these experiences were detrimental to social ties between mothers and members of the mainstream society, including their children's teachers. Finally, immigration policies were perceived to affect parent-child ties negatively, as mothers reported family stress, financial hardship, and decreased parental availability. PMID:24371370

Collective Functionality through Bacterial Individuality

NASA Astrophysics Data System (ADS)

Ackermann, Martin

According to the conventional view, the properties of an organism are a product of nature and nurture - of its genes and the environment it lives in. Recent experiments with unicellular organisms have challenged this view: several molecular mechanisms generate phenotypic variation independently of environmental signals, leading to variation in clonal groups. My presentation will focus on the causes and consequences of this microbial individuality. Using examples from bacterial genetic model systems, I will first discuss different molecular and cellular mechanisms that give rise to bacterial individuality. Then, I will discuss the consequences of individuality, and focus on how phenotypic variation in clonal populations of bacteria can promote interactions between individuals, lead to the division of labor, and allow clonal groups of bacteria to cope with environmental uncertainty. Variation between individuals thus provides clonal groups with collective functionality.

Attitudes and attitude change.

PubMed

Petty, R E; Wegener, D T; Fabrigar, L R

1997-01-01

We review empirical and conceptual developments over the past four years (1992-1995) on attitudes and persuasion. A voluminous amount of material was produced concerning attitude structure, attitude change, and the consequences of holding attitudes. In the structure area, particular attention is paid to work on attitude accessibility, ambivalence, and the affective versus cognitive bases of attitudes. In persuasion, our review examines research that has focused on high effort cognitive processes (central route), low effort processes (peripheral route), and the multiple roles by which variables can have an impact on attitudes. Special emphasis is given to work on cognitive dissonance and other biases in message processing, and on the multiple processes by which mood influences evaluations. Work on the consequences of attitudes focuses on the impact of attitudes on behavior and social judgments.

Wait time management strategies for total joint replacement surgery: sustainability and unintended consequences.

PubMed

Pomey, Marie-Pascale; Clavel, Nathalie; Amar, Claudia; Sabogale-Olarte, Juan Carlos; Sanmartin, Claudia; De Coster, Carolyn; Noseworthy, Tom

2017-09-07

In Canada, long waiting times for core specialized services have consistently been identified as a key barrier to access. Governments and organizations have responded with strategies for better access management, notably for total joint replacement (TJR) of the hip and knee. While wait time management strategies (WTMS) are promising, the factors which influence their sustainable implementation at the organizational level are understudied. Consequently, this study examined organizational and systemic factors that made it possible to sustain waiting times for TJR within federally established limits and for at least 18 months or more. The research design is a multiple case study of WTMS implementation. Five cases were selected across five Canadian provinces. Three success levels were pre-defined: 1) the WTMS maintained compliance with requirements for more than 18 months; 2) the WTMS met requirements for 18 months but could not sustain the level thereafter; 3) the WTMS never met requirements. For each case, we collected documents and interviewed key informants. We analyzed systemic and organizational factors, with particular attention to governance and leadership, culture, resources, methods, and tools. We found that successful organizations had specific characteristics: 1) management of the whole care continuum, 2) strong clinical leadership; 3) dedicated committees to coordinate and sustain strategy; 4) a culture based on trust and innovation. All strategies led to relatively similar unintended consequences. The main negative consequence was an initial increase in waiting times for TJR and the main positive consequence was operational enhancement of other areas of specialization based on the TJR model. This study highlights important differences in factors which help to achieve and sustain waiting times. To be sustainable, a WTMS needs to generate greater synergies between contextual-level strategy (provincial or regional) and organizational objectives and constraints. Managers at the organizational level should be vigilant with regard to unintended consequences that a WTMS in one area can have for other areas of care. A more systemic approach to sustainability can help avoid or mitigate undesirable unintended consequences.

Type and Location of Wearable Sensors for Monitoring Falls during Static and Dynamic Tasks in Healthy Elderly: A Review

PubMed Central

Sorriso, Antonietta; Liparoti, Marianna; Ferraioli, Giampaolo; Sorrentino, Pierpaolo

2018-01-01

In recent years, the meaning of successful living has moved from extending lifetime to improving the quality of aging, mainly in terms of high cognitive and physical functioning together with avoiding diseases. In healthy elderly, falls represent an alarming accident both in terms of number of events and the consequent decrease in the quality of life. Stability control is a key approach for studying the genesis of falls, for detecting the event and trying to develop methodologies to prevent it. Wearable sensors have proved to be very useful in monitoring and analyzing the stability of subjects. Within this manuscript, a review of the approaches proposed in the literature for fall risk assessment, fall prevention and fall detection in healthy elderly is provided. The review has been carried out by using the most adopted publication databases and by defining a search strategy based on keywords and boolean algebra constructs. The analysis aims at evaluating the state of the art of such kind of monitoring, both in terms of most adopted sensor technologies and of their location on the human body. The review has been extended to both dynamic and static analyses. In order to provide a useful tool for researchers involved in this field, the manuscript also focuses on the tests conducted in the analyzed studies, mainly in terms of characteristics of the population involved and of the tasks used. Finally, the main trends related to sensor typology, sensor location and tasks have been identified. PMID:29783647

Utilization of oral health care services among adults attending community outreach programs.

PubMed

Kadaluru, Umashankar Gangadhariah; Kempraj, Vanishree Mysore; Muddaiah, Pramila

2012-01-01

Good oral health is a mirror of overall health and well-being. Oral health is determined by diet, oral hygiene practices, and the pattern of dental visits. Poor oral health has significant social and economic consequences. Outreach programs conducted by dental schools offer an opportunity for early diagnosis and treatment, dental health education, and institution of preventive measures. To assess the utilization of oral healthcare services among adults attending outreach programs. This study included 246 adults aged 18-55 years attending community outreach programs in and around Bangalore. Using a questionnaire we collected data on dental visits, perceived oral health status, reasons for seeking care, and barriers in seeking care. Statistical significance was assessed using the Chi-square test. In this sample, 28% had visited the dentist in the last 12 months. Males visited dentist more frequently than females. The main reason for a dental visit was for tooth extraction (11%), followed by restorative and endodontic treatment 6%. The main barriers to utilization of dental services were high cost (22%), inability to take time off from child care duties (19.5%), and fear of the dentist or dental tools (8.5%). The utilization of dental services in this population was poor. The majority of the dental visits were for treatment of acute symptoms rather than for preventive care. High cost was the main barrier to the utilization of dental services. Policies and programs should focus on these factors to decrease the burden of oral diseases and to improve quality of life among the socioeconomically disadvantaged.

Marketing of surplus water from Federal reservoirs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dunn, J.M.

1978-01-01

Main-stem reservoirs were constructed and agricultural production flourished to the point of crop surpluses in the Missouri River basin. Consequently, the irrigation that was promised for the upper-basin states was not pursued as originally planned. The result was unappropriated surplus water available for commitments to future use. In recent years, when the nation's need for increased energy production became a reality, attention began focusing on the actual commitments of those surpluses. Conflicts between water for energy and water for agriculture were inevitable. On February 24, 1975 Secretaries of the Army and Interior entered into a ''Memorandum of Understanding'' concerning themore » marketing of surplus water from six reservoirs on the main stem of the Missouri River. The memorandum was executed in order to expedite plans for using large amounts of coal in the Dakotas, Montana, and Wyoming for developing new energy supplies. The purpose of the memorandum was to permit the possible execution of industrial-water-service contracts of approximately one million acre feet of main-stem storage water. This Comment examines two initial questions raised by the Federal proposals to sell impounded reservoir water to industrial users. First, what are the rights or powers of the states to control water within their borders, and second, what legal authority, constitutional, legislative, or otherwise, do the Departments of the Interior and Army have for industrial water marketing from Federal reservoirs. Other collateral yet significant issues are considered as well. One fact concluded is that the constitutional authority of the Federal government to control the disposition of water in Federal reservoirs is almost unlimited. (MCW)« less

Perceived sexual harassment at work: meta-analysis and structural model of antecedents and consequences.

PubMed

Topa Cantisano, Gabriela; Morales Domínguez, J F; Depolo, Marco

2008-05-01

Although sexual harassment has been extensively studied, empirical research has not led to firm conclusions about its antecedents and consequences, both at the personal and organizational level. An extensive literature search yielded 42 empirical studies with 60 samples. The matrix correlation obtained through meta-analytic techniques was used to test a structural equation model. Results supported the hypotheses regarding organizational environmental factors as main predictors of harassment.

Decadal responses in soil N dynamics at the Bear Brook Watershed in Maine, USA

Treesearch

Sultana Jefts; Ivan J. Fernandez; Lindwey E. Rustad; D. Bryan Dail

2004-01-01

Atmospheric nitrogen deposition to forested ecosystems is a concern because of both geochemical and biological consequences for ecosystem integrity. High levels of prolonged N deposition can lead to "N saturation" of the ecosystem. The Bear Brook Watershed in Maine is a long-term, paired forested watershed experiment with over a decade of experimental N...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Del Tutto, Marco

This thesis presents a study of the NuMI beam line intended to clarify how the particle trajectories through the focusing system and consequently the neutrino event yield are affected by the variation of the Horn Currents.

Relationship between energy dense diets and white adipose tissue inflammation in metabolic syndrome.

PubMed

Alemany, Marià

2013-01-01

Metabolic syndrome (MS) is a widespread pathologic state that manifests as multiple intertwined diseases affecting the entire body. This review analyzes the contribution of adipose tissue inflammation to its development. The main factor in the appearance of MS is an excess of dietary energy (largely fats), eliciting insulin resistance and creating the problem of excess energy disposal. Under these conditions, amino acid catabolism is diminished, which indirectly alters the production of nitric oxide and affects blood flow regulation. The oxidation of nitric oxide to nitrite and nitrate affects microbiota composition and functions. Adipose tissue cannot incorporate excessive nutrients after cell enlargement and loss of function. Tissue damage is a form of aggression, and the response is proinflammatory cytokine release. Cytokines favor the massive penetration of immune system cells, such as macrophages, which unsuccessfully try to fight an elusive danger for which they are not prepared. The consequence is low-level maintenance of the inflammatory state, which affects endoplasmic reticulum function and the endothelial response to excess regulatory mechanisms affecting blood flow and substrate/oxygen supply. When inflammation becomes chronic, the pathologic consequences are disseminated throughout the body because unused substrates and signals from adipose tissue affect energy partitioning and organ function. This maintenance of an unbalanced state ultimately results in the establishment of MS and associated pathologies. New research should focus on identifying ways to disarm the inflammatory response of adipose tissue when the dangers of dietary excess have already been controlled. Copyright © 2013. Published by Elsevier Inc.

Cheques and challenges: business performance in New Zealand general practice.

PubMed

Greatbanks, Richard; Doolan-Noble, Fiona; McKenna, Alex

2017-09-01

INTRODUCTION New Zealand general practice mainly functions as small businesses, usually owned by a single or small group of doctors. Consequently, owners often have to balance the provision of patient care with varying funding priorities, changing patient needs and the pressures of running a sustainable business. Such balancing inevitably leads to tensions developing between these factors. AIM To explore and understand these tensions and responses to them, by examining the business performance measurements used by general practice. METHODS For this study, the unit of analysis and focus were individual practices, but qualitative semi-structured interviews with general practitioners (GPs) and practice managers were used to gather the data. RESULTS All participating practices had some form of governance or board review, where high-level aggregated business performance data were presented. More sophisticated business performance measures were evident in the larger, more developed practices and in practices functioning as community trusts. Examples of such measures included doctor utilisation and efficiency, appraisal of risk, patient satisfaction with services and responses to changes in patient demand. DISCUSSION As the number of general practices based on the traditional model decrease, a corresponding increase is likely in the establishment and development of 'super practices' based on a corporatized, multi-service, single-location model. Consequently, service delivery will become increasingly complex and will drive a need for increased sophistication in how general practice measures its business performance, thus ensuring a balance between high-quality, safe patient care and the maintenance of a sustainable business.

Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases.

PubMed

Carrera-Quintanar, Lucrecia; López Roa, Rocío I; Quintero-Fabián, Saray; Sánchez-Sánchez, Marina A; Vizmanos, Barbara; Ortuño-Sahagún, Daniel

2018-01-01

Gut microbiota (GM) plays several crucial roles in host physiology and influences several relevant functions. In more than one respect, it can be said that you "feed your microbiota and are fed by it." GM diversity is affected by diet and influences metabolic and immune functions of the host's physiology. Consequently, an imbalance of GM, or dysbiosis, may be the cause or at least may lead to the progression of various pathologies such as infectious diseases, gastrointestinal cancers, inflammatory bowel disease, and even obesity and diabetes. Therefore, GM is an appropriate target for nutritional interventions to improve health. For this reason, phytochemicals that can influence GM have recently been studied as adjuvants for the treatment of obesity and inflammatory diseases. Phytochemicals include prebiotics and probiotics, as well as several chemical compounds such as polyphenols and derivatives, carotenoids, and thiosulfates. The largest group of these comprises polyphenols, which can be subclassified into four main groups: flavonoids (including eight subgroups), phenolic acids (such as curcumin), stilbenoids (such as resveratrol), and lignans. Consequently, in this review, we will present, organize, and discuss the most recent evidence indicating a relationship between the effects of different phytochemicals on GM that affect obesity and/or inflammation, focusing on the effect of approximately 40 different phytochemical compounds that have been chemically identified and that constitute some natural reservoir, such as potential prophylactics, as candidates for the treatment of obesity and inflammatory diseases.

Phytochemicals That Influence Gut Microbiota as Prophylactics and for the Treatment of Obesity and Inflammatory Diseases

PubMed Central

Sánchez-Sánchez, Marina A.; Vizmanos, Barbara

2018-01-01

Gut microbiota (GM) plays several crucial roles in host physiology and influences several relevant functions. In more than one respect, it can be said that you “feed your microbiota and are fed by it.” GM diversity is affected by diet and influences metabolic and immune functions of the host's physiology. Consequently, an imbalance of GM, or dysbiosis, may be the cause or at least may lead to the progression of various pathologies such as infectious diseases, gastrointestinal cancers, inflammatory bowel disease, and even obesity and diabetes. Therefore, GM is an appropriate target for nutritional interventions to improve health. For this reason, phytochemicals that can influence GM have recently been studied as adjuvants for the treatment of obesity and inflammatory diseases. Phytochemicals include prebiotics and probiotics, as well as several chemical compounds such as polyphenols and derivatives, carotenoids, and thiosulfates. The largest group of these comprises polyphenols, which can be subclassified into four main groups: flavonoids (including eight subgroups), phenolic acids (such as curcumin), stilbenoids (such as resveratrol), and lignans. Consequently, in this review, we will present, organize, and discuss the most recent evidence indicating a relationship between the effects of different phytochemicals on GM that affect obesity and/or inflammation, focusing on the effect of approximately 40 different phytochemical compounds that have been chemically identified and that constitute some natural reservoir, such as potential prophylactics, as candidates for the treatment of obesity and inflammatory diseases. PMID:29785173

Balanced complex chromosome rearrangements: reproductive aspects. A review.

PubMed

Madan, Kamlesh

2012-04-01

This review examines the reproductive consequences for carriers of a balanced complex chromosome rearrangement (CCR). It is based on an analysis of CCRs in 103 adults referred for reproductive problems, including male infertility. The main focus is on reproductive risks based on data from 84 CCRs. Carriers of balanced CCRs have a high risk of an abortion and/or a chromosomally unbalanced child. I have identified roughly four different types of CCRs (I-IV); most (44%) belong to Type I with a simple 3-way or 4-way exchange of segments and risk factors similar to those for reciprocal translocations. There were only three CCRs (4%) of type II, which involve an inversion. Type III CCRs (21%) involve one or more insertions with ∼35% risk of a child with a duplication or a deletion of the inserted segment. Type IV CCRs (31%) involve a "middle segment" in a derivative chromosome with segments from at least three chromosomes. In ∼35% of these CCRs, recombination occurs in this segment, which can produce imbalance but in many cases it changes a CCR into a simpler balanced rearrangement in the next generation. Balanced CCRs, which have been often considered together in one group, can now be split into four types, each with a risk of a different type of imbalance. This analysis provides a better understanding of the reproductive consequences for carriers of balanced CCRs and should be useful in prenatal diagnosis and genetic counseling. Copyright © 2012 Wiley Periodicals, Inc.

Dynamics of Chromospheres

NASA Astrophysics Data System (ADS)

Hasan, S. S.

2002-05-01

This review focuses on dynamics of the solar chromosphere, which serves as a good proxy for understanding processes in stellar chromospheres. In the quiet chromosphere we distinguish between the magnetic network on the boundary of supergranulation cells, where strong magnetic fields are organized in mainly vertical magnetic flux tubes, and internetwork regions in the cell interior, where magnetic fields are weak and dynamically unimportant. Observations have firmly established the presence of oscillations in the solar chromosphere. The internetwork medium is dominated with oscillations having power in the 5-7 mHz range, which can essentially be regarded as acoustic waves. Significant progress has been made recently in modeling wave propagation in the non-magnetic medium and applying these calculations to interpreting the properties of K2V grains. Nevertheless, there are still several open questions which need to be addressed, specifically the departure from 1-D geometry and the inclusion of oblique propagation: these can have important consequences. The dynamics of the magnetic network, on the other hand, is dominated by low frequency waves with periods in the 4-15 min. range, which can be interpreted as transverse MHD waves, generated in thin flux tubes by granular buffeting. Through nonlinear effects, these modes generate longitudinal MHD waves, that form shocks and dissipate in the low to middle chromosphere. Alternative theoretical scenarios for interpreting network oscillations will also be discussed as well as their observational consequences. Finally, we consider some implications of the above models to stellar chromospheres.

Physical behaviour of anthropogenic light propagation into the nocturnal environment

PubMed Central

Aubé, Martin

2015-01-01

Propagation of artificial light at night (ALAN) in the environment is now known to have non negligible consequences on fauna, flora and human health. These consequences depend on light levels and their spectral power distributions, which in turn rely on the efficiency of various physical processes involved in the radiative transfer of this light into the atmosphere and its interactions with the built and natural environment. ALAN can affect the living organisms by direct lighting and indirect lighting (scattered by the sky and clouds and/or reflected by local surfaces). This paper mainly focuses on the behaviour of the indirect light scattered under clear sky conditions. Various interaction processes between anthropogenic light sources and the natural environment are discussed. This work mostly relies on a sensitivity analysis conducted with the light pollution radiative transfer model, Illumina (Aubé et al. 2005 Light pollution modelling and detection in a heterogeneous environment: toward a night-time aerosol optical depth retrieval method. In Proc. SPIE 2005, vol. 5890, San Diego, California, USA). More specifically, the impact of (i) the molecular and aerosol scattering and absorption, (ii) the second order of scattering, (iii) the topography and obstacle blocking, (iv) the ground reflectance and (v) the spectrum of light devices and their angular emission functions are examined. This analysis considers different behaviour as a function of the distance from the city centre, along with different zenith viewing angles in the principal plane. PMID:25780231

Short- and long-term impact of critical illness on relatives: literature review.

PubMed

Paul, Fiona; Rattray, Janice

2008-05-01

This paper is a report of a literature review undertaken to identify the short- and long-term impact of critical illness on relatives. Patients in intensive care can experience physical and psychological consequences, and their relatives may also experience such effects. Although it is recognized that relatives have specific needs, it is not clear whether these needs are always met and whether further support is required, particularly after intensive care. The following databases were searched for the period 1950-2007: Medline, British Nursing Index and Archive, EMBASE, CINAHL, PsycINFO and EMB Reviews--Cochrane Central Register of Clinical Trials. Search terms focused on adult relatives of critically ill adult patients during and after intensive care. Recurrent topics were categorized to structure the review, i.e. 'relatives needs', 'meeting relatives' needs', 'interventions', 'satisfaction', 'psychological outcomes' and 'coping'. Studies have mainly identified relatives' immediate needs using the Critical Care Family Needs Inventory. There are few studies of interventions to meet relatives' needs and the short- and long-term effects of critical illness on relatives. Despite widespread use of the Critical Care Family Needs Inventory, factors such as local or cultural differences may influence relatives' needs. Relatives may also have unidentified needs, and these needs should be explored. Limited research has been carried out into interventions to meet relatives' needs and the effects of critical illness on their well-being, yet some relatives may experience negative psychological consequences far beyond the acute phase of the illness.

Physical behaviour of anthropogenic light propagation into the nocturnal environment.

PubMed

Aubé, Martin

2015-05-05

Propagation of artificial light at night (ALAN) in the environment is now known to have non negligible consequences on fauna, flora and human health. These consequences depend on light levels and their spectral power distributions, which in turn rely on the efficiency of various physical processes involved in the radiative transfer of this light into the atmosphere and its interactions with the built and natural environment. ALAN can affect the living organisms by direct lighting and indirect lighting (scattered by the sky and clouds and/or reflected by local surfaces). This paper mainly focuses on the behaviour of the indirect light scattered under clear sky conditions. Various interaction processes between anthropogenic light sources and the natural environment are discussed. This work mostly relies on a sensitivity analysis conducted with the light pollution radiative transfer model, Illumina (Aubé et al. 2005 Light pollution modelling and detection in a heterogeneous environment: toward a night-time aerosol optical depth retrieval method. In Proc. SPIE 2005, vol. 5890, San Diego, California, USA). More specifically, the impact of (i) the molecular and aerosol scattering and absorption, (ii) the second order of scattering, (iii) the topography and obstacle blocking, (iv) the ground reflectance and (v) the spectrum of light devices and their angular emission functions are examined. This analysis considers different behaviour as a function of the distance from the city centre, along with different zenith viewing angles in the principal plane. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

[Drug-food interactions in internal medicine: What physicians should know?].

PubMed

Mouly, S; Morgand, M; Lopes, A; Lloret-Linares, C; Bergmann, J-F

2015-08-01

Orally administered medications may interact with various fruits, vegetables, herbal medicines, functional foods or dietary supplements. Drug-food interactions, which are mostly unknown from prescribers, including internists, may be responsible for changes in drug plasma concentrations, which may decrease efficacy or led to sometimes life-threatening toxicity. Aging, concomitant medications, transplant recipients, patients with cancer, malnutrition, HIV infection and those receiving enteral or parenteral feeding are at increased risk of drug-food interactions. This review focused on the most clinically relevant drug-food interactions, including those with grapefruit juice, Saint-John's Wort, enteral or parenteral nutrition, their respective consequences in the clinical setting in order to provide thoughtful information for internists in their routine clinical practice. Specific clinical settings are also detailed, such as the Ramadan or multiple medications especially in elderly patients. Drug-food interactions are also presented with respect to the main therapeutic families, including the non-steroidal anti-inflammatory drugs, analgesics, cardiovascular medications, warfarin as well as new oral anticoagulants, anticancer drugs and immunosuppressant medications. Considerable effort has been achieved to a better understanding of food-drug interactions and increase clinicians' ability to anticipate their occurrence and consequences in clinical practice. Describing the frequency of relevant food-drug interactions in internal medicine is paramount in order to optimize patient care and drug dosing on an individual basis as well as to increase patients and doctors information. Copyright © 2015 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

Do distributaries in a delta plain resemble an ideal estuary? Results from theKapuas Delta,Indonesia

NASA Astrophysics Data System (ADS)

Hoitink, T.; Kastner, K.; Vermeulen, B.; Geertsema, T.; Nining, S. N.

2017-12-01

Coastal lowland plains under mixed fluvial-tidal influence can form complex channel networks, where distributaries blend the characteristics of mouth bar channels, avulsion channels and tidal creeks. These networks are shaped by the interplay of river flow and tides. Our goal is to increase the general understanding of physical processes in the fluvial-tidal transition. Here we present first results of an extensive field survey of the Kapuas river and give insight into the along channel trends of cross section geometry and bed material grain size. main distributary and slightly increases in downstream direction (Fig. 2c).The Kapuas river is a large tropical river in West Kalimantan, Indonesia. Discharge ranges between 10^3 m^3/s in the wet and 10^4 m^3/s in the dry season. The Kapuas consists of one main distributary from which three smaller distributaries branch off along the alluvial plain (Fig. 1a). Tides are mainly diurnal, with an average spring range of 1.5m at the mouth.Figure 1: Map of the Kapuas river delta plain Between 2013 and 2015 we surveyed the Kapuas from the sea to upstream km 300. Bankfull river width was extracted from Landsat images. Bathymetry was surveyed with a single beam each sounder. Bed material was sampled with a van Veen grabber. The geometry of the Kapuas river deviates from that of an idealized estuary, as it does not converge to an equilibirum width and depth. Such a break in scaling was previously found in the Mahakam Delta by Sassi et al. 2012, which suggests this may be a general characteristic in the fluvial to tidal transition. There is no simple relation between bed material grain size and channel geometry. The particular geometry of the Kapuas also leads to particular hydrodynamics in the fluvial-tidal transition. Thus the draw-down curve during high flow and backwater curve at flow are much less pronounced in the Kapuas, and tides propagate far up the river. At the moment we investigate the consequences for river discharge-tide interaction. In particular we focus on propagation of the tide depending on the river discharge as well as consequences for delta morphology.

The Consequences for Women of the Availability and Affordability of Child Care

DTIC Science & Technology

1988-07-01

00 THE CONSEQUENCES FOR WOMEN OF THE AVAILABILITY AND AFFORDABILITY OF CHILD CARE Arleen Leibowitz Linda J. Waite July 1988 DTI -%ELECTEE NOV07 IM P...Research Council’s Committee on Child Care. It focuses on the effects for women of the availability and affordability of child care, concentrating...especially on effects on women’s employment and earnings. The paper discusses the implications of raising the wages of child care workers, of the

Italian Adolescents and Emergency Contraception: A Focus Group Study.

PubMed

Olivari, Maria Giulia; Cuccì, Gaia; Confalonieri, Emanuela

2017-02-01

Using a qualitative method, the purpose of this study was to: (1) obtain information directly from the adolescents on their attitudes and knowledge regarding emergency contraception; and (2) investigate the presence of differences between male and female participants' attitudes and knowledge. This study consisted of 24 single-sex focus groups with 160 adolescents (male = 46.3% (74 of 160); female = 53.7% (86 of 160)) aged 15-19 years conducted among high schools in 3 regions of Italy. Data were analyzed through thematic analysis taking into account gender differences and 2 main themes emerged. The first was labeled "Adolescents' attitudes toward emergency contraception" and it was divided into 3 subthemes: You should be aware; It's a life line; and Everything but a child. The second theme was labeled "Adolescents' knowledge toward emergency contraception" and it was divided into 3 subthemes: False myths; Baseline information; and Just take it. Italian adolescents believed it is important to prevent the risk of unprotected sex by using contraceptive methods and their motivation to use emergency contraception is related to critical attitudes toward the consequences of irresponsible/ineffective contraception. Although adolescents have an awareness of emergency contraception, more comprehensive knowledge is needed. These findings can inform specific interventions aimed at educating adolescents in need of emergency contraception. Copyright © 2016 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved.

Mapping discourses using Q methodology in Matang Mangrove Forest, Malaysia.

PubMed

Hugé, Jean; Vande Velde, Katherine; Benitez-Capistros, Francisco; Japay, Jan Harold; Satyanarayana, Behara; Nazrin Ishak, Mohammad; Quispe-Zuniga, Melissa; Mohd Lokman, Bin Husain; Sulong, Ibrahim; Koedam, Nico; Dahdouh-Guebas, Farid

2016-12-01

The sustainable management of natural resources requires the consideration of multiple stakeholders' perspectives and knowledge claims, in order to inform complex and possibly contentious decision-making dilemmas. Hence, a better understanding of why people in particular contexts do manage natural resources in a particular way is needed. Focusing on mangroves, highly productive tropical intertidal forests, this study's first aim is to map the diversity of subjective viewpoints among a range of stakeholders on the management of Matang Mangrove Forest in peninsular Malaysia. Secondly, this study aims to feed the reflection on the possible consequences of the diversity of perspectives for the future management of mangroves in Malaysia and beyond. The use of the semi-quantitative Q methodology allowed us to identify three main discourses on mangrove management: i. the optimization discourse, stressing the need to improve the current overall satisfactory management regime; ii. the 'change for the better' discourse, which focuses on increasingly participatory management and on ecotourism; and iii. the conservative 'business as usual' discourse. The existence of common points of connection between the discourses and their respective supporters provides opportunities for modifications of mangrove management regimes. Acknowledging this diversity of viewpoints, reflecting how different stakeholders see and talk about mangrove management, highlights the need to develop pro-active and resilient natural resource management approaches. Copyright © 2016 Elsevier Ltd. All rights reserved.

The Cancer, Educate to Prevent Model-the Potential of School Environment for Primary Prevention of Cancer.

PubMed

Barros, A; Santos, H; Moreira, L; Ribeiro, N; Silva, L; Santos-Silva, F

2016-12-01

Cancer represents one of the main causes of death worldwide; consequently, preventive interventions are of utmost importance in public health education. The leading model of cancer prevention campaigns is based on general and undifferentiated actions mediated by health professionals, focusing on the technical and scientific information but rather ineffective in changing the symbolic, cognitive and practical relationship with the disease. New intervention models are thus required to address cancer literacy, being early interventions targeted to specific groups an elective counterpoint to contribute to positive and durable changes in cancer prevention. Our aim is to evaluate the feasibility and impact of cancer prevention programmes planned as focused interventions in restricted targets and mediated by non-healthcare professionals to increase cancer literacy and promote preventive behaviours. This pilot study evaluates schools' potential as a vehicle for cancer prevention education in a reality shaped by traditional health prevention campaigns. We developed a protocol of systematic surveying in order to review and, in the future, optimize and replicate this ecological model of intervention to other groups and contexts. The implementation of this model has been successful in which concerns to the effectiveness of the training programme for teachers. This led to the development of impactful cancer prevention education projects by trainees targeted to their students, allowing us to argue that it contributes to knowledge and practice in this complex as consensual priority area of intervention.

The provision of ecosystem services in response to global change: Evidences and applications.

PubMed

Lafortezza, Raffaele; Chen, Jiquan

2016-05-01

As a consequence of the global increase in economic and societal prosperity, ecosystems and natural resources have been substantially exploited, degraded, or even destroyed in the last century. To prevent further deprivation of the quality of ecosystems, the ecosystem services concept has become a central issue in environmental studies. A growing number of environmental agencies and organizations worldwide are now embracing integrated approaches to plan and manage ecosystems, sharing a goal to maintain the long-term provision of ecosystem services for sustainability. A daunting challenge in this process is to move from general pronouncements about the tremendous benefits that ecosystems provide to society to defensible assessments of their services. In other words, we must move beyond the scientific evidences of the ecosystem services concept to its practical applications. In this work, we discuss the theoretical foundations and applications of ecosystem services with a focus on the assessment of ecosystem service trade-offs and synergies at various spatial and temporal scales. Here, we offer examples of the main factors related to land use management that may affect the provision of ecosystem services and provide direction for future research on ecosystem services and related nature-based solutions. We also provide a briefing on the major topics covered in this Special Issue, which focuses on the provision of ecosystem services in the context of global change. Copyright © 2016 Elsevier Inc. All rights reserved.

Enhancing relaxation states and positive emotions in physicians through a mindfulness training program: A one-year study.

PubMed

Amutio, Alberto; Martínez-Taboada, Cristina; Hermosilla, Daniel; Delgado, Luis Carlos

2015-01-01

Previous research on mindfulness has focused mainly on stress-related negative symptoms and short-term effects. In contrast, the present article focuses on the impact of a mindfulness-based stress reduction (MBSR) program on improving well-being (i.e. relaxation states and related positive emotions) in a longitudinal study for a period of one year. A randomized controlled trial in a sample of 42 physicians was used. The intervention group participated in an 8-week MBSR program, with an additional 10-month maintenance period and completed measures of mindfulness and relaxation at pre-intervention, post-intervention and after 10 months. Heart rate measures were also obtained. Significant improvements in favor of the experimental group compared with the control group on the levels of mindfulness and relaxation (including positive emotional states, such as at ease/peace, renewal, energy, optimism, happiness, acceptance, and even transcendence) were obtained after eight weeks. Remarkably, change magnitudes (effect size) significantly increased at the end of the maintenance period after a year, especially for mindfulness and positive energy. Additionally, heart rate significantly decreased for the intervention group and maintained a year after the beginning of the treatment. Results are relevant in terms of practical consequences for improving health and well-being in this population and also in terms of cost-efficiency.

Extraction of Organochlorine Pesticides from Plastic Pellets and Plastic Type Analysis.

PubMed

Pflieger, Marilyne; Makorič, Petra; Kovač Viršek, Manca; Koren, Špela

2017-07-01

Plastic resin pellets, categorized as microplastics (≤5 mm in diameter), are small granules that can be unintentionally released to the environment during manufacturing and transport. Because of their environmental persistence, they are widely distributed in the oceans and on beaches all over the world. They can act as a vector of potentially toxic organic compounds (e.g., polychlorinated biphenyls) and might consequently negatively affect marine organisms. Their possible impacts along the food chain are not yet well understood. In order to assess the hazards associated with the occurrence of plastic pellets in the marine environment, it is necessary to develop methodologies that allow for rapid determination of associated organic contaminant levels. The present protocol describes the different steps required for sampling resin pellets, analyzing adsorbed organochlorine pesticides (OCPs) and identifying the plastic type. The focus is on the extraction of OCPs from plastic pellets by means of a pressurized fluid extractor (PFE) and on the polymer chemical analysis applying Fourier Transform-InfraRed (FT-IR) spectroscopy. The developed methodology focuses on 11 OCPs and related compounds, including dichlorodiphenyltrichloroethane (DDT) and its two main metabolites, lindane and two production isomers, as well as the two biologically active isomers of technical endosulfan. This protocol constitutes a simple and rapid alternative to existing methodology for evaluating the concentration of organic contaminants adsorbed on plastic pieces.

Diversity of the Epsilonproteobacteria Dsb (disulfide bond) systems

PubMed Central

Bocian-Ostrzycka, Katarzyna M.; Grzeszczuk, Magdalena J.; Dziewit, Lukasz; Jagusztyn-Krynicka, Elżbieta K.

2015-01-01

The bacterial proteins of the Dsb family—important components of the post-translational protein modification system—catalyze the formation of disulfide bridges, a process that is crucial for protein structure stabilization and activity. Dsb systems play an essential role in the assembly of many virulence factors. Recent rapid advances in global analysis of bacteria have thrown light on the enormous diversity among bacterial Dsb systems. While the Escherichia coli disulfide bond-forming system is quite well understood, the mechanisms of action of Dsb systems in other bacteria, including members of class Epsilonproteobacteria that contain pathogenic and non-pathogenic bacteria colonizing extremely diverse ecological niches, are poorly characterized. Here we present a review of current knowledge on Epsilonproteobacteria Dsb systems. We have focused on the Dsb systems of Campylobacter spp. and Helicobacter spp. because our knowledge about Dsb proteins of Wolinella and Arcobacter spp. is still scarce and comes mainly from bioinformatic studies. Helicobacter pylori is a common human pathogen that colonizes the gastric epithelium of humans with severe consequences. Campylobacter spp. is a leading cause of zoonotic enteric bacterial infections in most developed and developing nations. We focus on various aspects of the diversity of the Dsb systems and their influence on pathogenicity, particularly because Dsb proteins are considered as potential targets for a new class of anti-virulence drugs to treat human infections by Campylobacter or Helicobacter spp. PMID:26106374

Multidimensional human dynamics in mobile phone communications.

PubMed

Quadri, Christian; Zignani, Matteo; Capra, Lorenzo; Gaito, Sabrina; Rossi, Gian Paolo

2014-01-01

In today's technology-assisted society, social interactions may be expressed through a variety of techno-communication channels, including online social networks, email and mobile phones (calls, text messages). Consequently, a clear grasp of human behavior through the diverse communication media is considered a key factor in understanding the formation of the today's information society. So far, all previous research on user communication behavior has focused on a sole communication activity. In this paper we move forward another step on this research path by performing a multidimensional study of human sociality as an expression of the use of mobile phones. The paper focuses on user temporal communication behavior in the interplay between the two complementary communication media, text messages and phone calls, that represent the bi-dimensional scenario of analysis. Our study provides a theoretical framework for analyzing multidimensional bursts as the most general burst category, that includes one-dimensional bursts as the simplest case, and offers empirical evidence of their nature by following the combined phone call/text message communication patterns of approximately one million people over three-month period. This quantitative approach enables the design of a generative model rooted in the three most significant features of the multidimensional burst - the number of dimensions, prevalence and interleaving degree - able to reproduce the main media usage attitude. The other findings of the paper include a novel multidimensional burst detection algorithm and an insight analysis of the human media selection process.

Effect of ethyleneoxide groups of anionic surfactants on lipase activity.

PubMed

Magalhães, Solange S; Alves, Luís; Sebastião, Marco; Medronho, Bruno; Almeida, Zaida L; Faria, Tiago Q; Brito, Rui M M; Moreno, Maria J; Antunes, Filipe E

2016-09-01

The use of enzymes in laundry and dish detergent products is growing. Such tendency implies dedicated studies to understand surfactant-enzyme interactions. The interactions between surfactants and enzymes and their impact on the catalytic efficiency represent a central problem and were here evaluated using circular dichroism, dynamic light scattering, and enzyme activity determinations. This work focuses on this key issue by evaluating the role of the ethyleneoxide (EO) groups of anionic surfactants on the structure and activity of a commercial lipase, and by focusing on the protein/surfactant interactions at a molecular level. The conformational changes and enzymatic activity of the protein were evaluated in the presence of sodium dodecyl sulfate (SDS also denoted as SLE 0 S) and of sodium lauryl ether sulfate with two EO units (SLE 2 S). The results strongly suggest that the presence of EO units in the surfactant polar headgroup determines the stability and the activity of the enzyme. While SDS promotes enzyme denaturation and consequent loss of activity, SLE 2 S preserves the enzyme structure and activity. The data further highlights that the electrostatic interactions among the protein groups are changed by the presence of the adsorbed anionic surfactants being such absorption mainly driven by hydrophobic interactions. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:1276-1282, 2016. © 2016 American Institute of Chemical Engineers.

Robust Emergent Climate Phenomena Associated with the High-Sensitivity Tail

NASA Astrophysics Data System (ADS)

Boslough, M.; Levy, M.; Backus, G.

2010-12-01

Because the potential effects of climate change are more severe than had previously been thought, increasing focus on uncertainty quantification is required for risk assessment needed by policy makers. Current scientific efforts focus almost exclusively on establishing best estimates of future climate change. However, the greatest consequences occur in the extreme tail of the probability density functions for climate sensitivity (the “high-sensitivity tail”). To this end, we are exploring the impacts of newly postulated, highly uncertain, but high-consequence physical mechanisms to better establish the climate change risk. We define consequence in terms of dramatic change in physical conditions and in the resulting socioeconomic impact (hence, risk) on populations. Although we are developing generally applicable risk assessment methods, we have focused our initial efforts on uncertainty and risk analyses for the Arctic region. Instead of focusing on best estimates, requiring many years of model parameterization development and evaluation, we are focusing on robust emergent phenomena (those that are not necessarily intuitive and are insensitive to assumptions, subgrid-parameterizations, and tunings). For many physical systems, under-resolved models fail to generate such phenomena, which only develop when model resolution is sufficiently high. Our ultimate goal is to discover the patterns of emergent climate precursors (those that cannot be predicted with lower-resolution models) that can be used as a "sensitivity fingerprint" and make recommendations for a climate early warning system that would use satellites and sensor arrays to look for the various predicted high-sensitivity signatures. Our initial simulations are focused on the Arctic region, where underpredicted phenomena such as rapid loss of sea ice are already emerging, and because of major geopolitical implications associated with increasing Arctic accessibility to natural resources, shipping routes, and strategic locations. We anticipate that regional climate will be strongly influenced by feedbacks associated with a seasonally ice-free Arctic, but with unknown emergent phenomena. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy under Contract DE-AC04-94AL85000.

Health in older cat and dog owners: The Nord-Trondelag Health Study (HUNT)-3 study.

PubMed

Enmarker, Ingela; Hellzén, Ove; Ekker, Knut; Berg, Ann-Grethe

2012-12-01

The main objective was to compare older male and female cat, dog, and non-owners with regard to demographic and health-related characteristics. Data in the present cross-sectional population study were drawn from HUNT-3 in Norway. A total of 12,297 persons (5631 men; 6666 women) between the ages of 65 and 101 years were included, of whom 2358 were pet owners. The main finding was that owning a dog demonstrated several health-related characteristics to a higher positive degree than both non-pet and cat ownership among the participants. Cat owners showed higher body mass index values and higher systolic blood pressure, and reported worse general health status. They also exercised to a lower degree than the others. As the result implies that older cat owners are negatively outstanding in many aspects of health compared with the dog owners, in the future, more focus must be put on the worse health of those. Further, there were more married male than female cat and dog owners. This probably depends on traditional cultural thinking; the man is the owner of the pet even if the woman lives with and cares about it. It is important to point out that different groups in the population might select different pets. Consequently, the findings showing a correlation between pet ownership and health may be owing to unrelated confounding factors.

Imaging deductive reasoning and the new paradigm

PubMed Central

Oaksford, Mike

2015-01-01

There has been a great expansion of research into human reasoning at all of Marr’s explanatory levels. There is a tendency for this work to progress within a level largely ignoring the others which can lead to slippage between levels (Chater et al., 2003). It is argued that recent brain imaging research on deductive reasoning—implementational level—has largely ignored the new paradigm in reasoning—computational level (Over, 2009). Consequently, recent imaging results are reviewed with the focus on how they relate to the new paradigm. The imaging results are drawn primarily from a recent meta-analysis by Prado et al. (2011) but further imaging results are also reviewed where relevant. Three main observations are made. First, the main function of the core brain region identified is most likely elaborative, defeasible reasoning not deductive reasoning. Second, the subtraction methodology and the meta-analytic approach may remove all traces of content specific System 1 processes thought to underpin much human reasoning. Third, interpreting the function of the brain regions activated by a task depends on theories of the function that a task engages. When there are multiple interpretations of that function, interpreting what an active brain region is doing is not clear cut. It is concluded that there is a need to more tightly connect brain activation to function, which could be achieved using formalized computational level models and a parametric variation approach. PMID:25774130

Experiences of reduced work hours for nurses and assistant nurses at a surgical department: a qualitative study.

PubMed

Gyllensten, Kristina; Andersson, Gunnar; Muller, Helena

2017-01-01

There is a shortage of registered nurses in the European Union (EU), and job dissatisfaction and perceived high work-family conflict have been identified as causes of nursing staff turnover. Reducing work hours is an organisational intervention that could have a positive effect on nurses' and assistant nurses' job satisfaction, work-life balance, and willingness to stay in the job. An orthopaedic surgery department at a large hospital in Sweden introduced reduced work hours for nurses and assistant nurses in order to improve the working situation. The aim of the study was to investigate the experiences of reduced work hours and no lunch breaks among nurses and assistant nurses at an orthopaedic surgery department at a hospital in Sweden, with a particular focus on recovery and psychosocial working environment. A qualitative design was used in the study. Eleven nurses and assistant nurses working at the particular orthopaedic department took part in the study, and semi-structured interviews were used to collect data. The interviews were analysed by interpretative phenomenological analysis. Four main themes were developed in the analysis of the data: A more sustainable working situation, Improved work-life balance, Consequences of being part of a project, and Improved quality of care. Each theme consisted of subthemes. Overall, reduced work hours appeared to have many, mainly positive, effects for the participants in both work and home life.

Body image and body change: predictive factors in an Iranian population.

PubMed

Garrusi, Behshid; Garousi, Saeide; Baneshi, Mohammad R

2013-08-01

Body concerns and its health consequences such as eating disorders and harmful body change activities are mentioned in Asian countries. This study evaluates factors contributing to body image/shape changes in an Iranian population. In this cross-sectional study we focused on four main body change activity (diet, exercise, substance use, and surgery) and their risk factors such as demographic variables, Body Mass Index (BMI), Media, Body-Esteem, Perceived Socio-cultural Pressure, Body dissatisfaction and, Self-Esteem. Approximately, 1,200 individuals between 14-55 years old participated in this study. We used a multistage sampling method. In each region, the first household was selected at random. The probability of outcomes was estimated from logistic models. About 54.3% of respondents were females. The mean (SD) of age was 31.06 (10.24) years. Variables such as gender, age, BMI, use of media and socio cultural factors as, body dissatisfaction, body-esteem and pressure by relatives were the main factors that influenced body change methods. In particular we have seen that male are 53% less likely to follow surgical treatments, but 125% were more likely to use substances. Investigation of body concern and its health related problem should be assessed in cultural context. For effectiveness of interventional programs and reducing harmful body image/shape changes activities, socio-cultural background should be noted.