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Sample records for conservador das estenoses

  1. DAS performance analysis

    SciTech Connect

    Bates, G.; Bodine, S.; Carroll, T.; Keller, M.

    1984-02-01

    This report begins with an overview of the Data Acquisition System (DAS), which supports several of PPPL's experimental devices. Performance measurements which were taken on DAS and the tools used to make them are then described.

  2. DAS User Manual

    NASA Astrophysics Data System (ADS)

    Østensen, Roy

    2008-10-01

    The HELAS Database for AsteroSeismology (DAS) is one of the deliverables of the Work Package NA5: Asteroseismology of the European Coordination Action in Helio- and Asteroseismology (HELAS). The DAS aims to provide easy access to publicly available asteroseismological timeseries data, both photometric and spectroscopic. In particular, the DAS and the HELAS software package FAMIAS are ideally suited to train Master and PhD students in asteroseismic data analysis and to build longterm datasets. The number of stars in the system is still limited and reflects the willingness of data owners to provide their data after publication. Work continues to populate the database with contributions from the community, and at present the number of stars in the database is 82

  3. Das DNA-Puzzle

    NASA Astrophysics Data System (ADS)

    Kirchner, Stefan

    Im Jahre 1953 wurde von James Watson und Francis Crick erstmalig der strukturelle Aufbau der sogenannten DNA (Desoxyribonukleinsäure) beschrieben, welche das Erbgut jedes Lebewesens enthält. Der wesentliche Teil des Erbguts wird dabei durch eine sehr lange Folge der vier Basen Adenin (A), Cytosin (C), Guanin (G) und Thymin (T) codiert. Seit einigen Jahren ist es möglich, die Folge der vier Basen zu einer gegebenen DNA zu bestimmen. Biologen bezeichnen diesen Vorgang als Sequenzierung.

  4. Das Zwillingsparadoxon: Gedankenexperimente

    NASA Astrophysics Data System (ADS)

    Genz, Henning

    2002-09-01

    Das vermeintliche Zwillingsparadoxon ist ein Gedankenexperiment mit einem Zwillingspaar: Ein Zwilling reist mit hoher Geschwindigkeit von der Erde weg und kehrt nach einiger Zeit zurück, sein Partner bleibt auf der Erde. Dabei altert der Reisende langsamer als der Ruhende - warum nicht umgekehrt? Ein Vergleich von Uhren, die sich mit konstanter Geschwindigkeit bewegen, zeigt: Der Effekt hängt nur von Geschwindigkeiten und nicht von Beschleunigungen ab. Er beruht also allein auf der Speziellen Relativitätstheorie. Tauschen die Zwillinge in regelmäßigen Abständen Lichtsignale aus, können sie ihr asymmetrisches Altern sogar in Zeitschritten mitprotokollieren.

  5. Das Allgemeine Statistische Archiv

    NASA Astrophysics Data System (ADS)

    Rinne, Horst

    Das Allgemeine Statistische Archiv1, nachfolgend kurz Archiv genannt, ist die älteste, ausschließlich der Statistik gewidmete deutschsprachige wissenschaftliche Fachzeitschrift. Sie ist gut zwanzig Jahre älter als die Deutsche Statistische Gesellschaft, zu deren Publikationsorgan sie mit der Gründung der Gesellschaft im Jahre 1911 wurde. Zeitschrift und Gesellschaft blicken auf eine sehr wechselvolle, aber erfolgreiche gemeinsame Geschichte zurück. Die wissenschaftliche Arbeit der Gesellschaft ist im Archiv und seinen Sonderheften für nachfolgende Generationen dokumentiert.

  6. Connecting the Dots in DAS

    ERIC Educational Resources Information Center

    Ford, Tracy

    2012-01-01

    Many institutions implement a distributed antenna system (DAS) as part of a holistic approach to providing better wireless coverage and capacity on campus. A DAS provides wireless service within a particular area or structure via a network of separate antenna nodes that are connected to a common source through fiber or coaxial cable. Because DAS…

  7. Connecting the Dots in DAS

    ERIC Educational Resources Information Center

    Ford, Tracy

    2012-01-01

    Many institutions implement a distributed antenna system (DAS) as part of a holistic approach to providing better wireless coverage and capacity on campus. A DAS provides wireless service within a particular area or structure via a network of separate antenna nodes that are connected to a common source through fiber or coaxial cable. Because DAS…

  8. MyDas, an extensible Java DAS server.

    PubMed

    Salazar, Gustavo A; García, Leyla J; Jones, Philip; Jimenez, Rafael C; Quinn, Antony F; Jenkinson, Andrew M; Mulder, Nicola; Martin, Maria; Hunter, Sarah; Hermjakob, Henning

    2012-01-01

    A large number of diverse, complex, and distributed data resources are currently available in the Bioinformatics domain. The pace of discovery and the diversity of information means that centralised reference databases like UniProt and Ensembl cannot integrate all potentially relevant information sources. From a user perspective however, centralised access to all relevant information concerning a specific query is essential. The Distributed Annotation System (DAS) defines a communication protocol to exchange annotations on genomic and protein sequences; this standardisation enables clients to retrieve data from a myriad of sources, thus offering centralised access to end-users.We introduce MyDas, a web server that facilitates the publishing of biological annotations according to the DAS specification. It deals with the common functionality requirements of making data available, while also providing an extension mechanism in order to implement the specifics of data store interaction. MyDas allows the user to define where the required information is located along with its structure, and is then responsible for the communication protocol details.

  9. Comparison of the DAS28-CRP and DAS28-ESR in patients with rheumatoid arthritis.

    PubMed

    Sengul, Ilker; Akcay-Yalbuzdag, Seniz; Ince, Bugra; Goksel-Karatepe, Altinay; Kaya, Taciser

    2015-07-01

    To compare the Disease Activity Score with 28 joint (DAS28) using erythrocyte sedimentation rate (ESR) (DAS28-ESR) and DAS28 using C-reactive protein (CRP) (DAS28-CRP) with thresholds validated for DAS28-ESR in Turkish patients with rheumatoid arthritis. The DAS28 data of 112 patients with rheumatoid arthritis followed in a local outpatient clinic were used. First, the correlation between DAS28-CRP and DAS28-ESR and the correlation between their unique components ([0.36 × In (CRP + 1) + 0.96] and [0.70 × In (ESR)]) were analyzed. Second, a Bland-Altman plot was constructed for the evaluation of the level of agreement between DAS28-CRP and DAS28-ESR. Lastly, the agreement between these two methods was analyzed by κ coefficient. Although there was a strong correlation between DAS28-CRP and DAS28-ESR, the correlation between their unique components was fair. Although more than 95% of the point data fall between the upper and lower bounds of the limit of agreement, the percentage error (46%) was higher than the acceptable proportion of 30%. The κ coefficient of agreement between DAS28- ESR and DAS28-CRP with validated thresholds for DAS28-ESR was 0.42, which was close to the lower boundary for moderate agreement. The results of this study demonstrated that there is discordance between DAS28-ESR and DAS28-CRP with the validated thresholds for DAS28-ESR. Using the DAS28-CRP with threshold values validated for DAS28-ESR may lead to errors in the determination of disease activity and therefore may lead to errors in the management of patients with rheumatoid arthritis. © 2015 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

  10. Data Acquisition System(DAS) Sustaining Engineering

    NASA Technical Reports Server (NTRS)

    1998-01-01

    This paper presents general information describing the Data Acquisition System contract, a summary of objectives, tasks performed and completed. The hardware deliverables which are comprised of: 1) Two ground DAS units; 2) Two flight DAS units; 3) Logistic spares; and 4) Shipping containers are described. Also included are the data requirements and scope of the contract.

  11. DAS28-CRP and DAS28-ESR cut-offs for high disease activity in rheumatoid arthritis are not interchangeable

    PubMed Central

    Fleischmann, Roy M; van der Heijde, Désirée; Gardiner, Philip V; Szumski, Annette; Marshall, Lisa; Bananis, Eustratios

    2017-01-01

    Background In most patients with rheumatoid arthritis (RA), Disease Activity Score 28-joint count C reactive protein (DAS28-CRP) is lower than DAS28 erythrocyte sedimentation rate (DAS28-ESR), suggesting that use of the DAS28-ESR cut-off to assess high disease activity (HDA) with DAS28-CRP may underestimate the number of patients with HDA. We determined the DAS28-CRP value corresponding to the validated DAS28-ESR cut-off for HDA. Methods Baseline data were pooled from 2 clinical studies evaluating etanercept (ETN) plus methotrexate (MTX) or MTX in early RA; DAS28-CRP and DAS28-ESR were obtained, allowing the determination of the DAS28-CRP HDA value best corresponding to the DAS28-ESR cut-off of >5.1. Results At baseline, as expected, fewer patients had HDA by DAS28-CRP than DAS28-ESR; DAS28-CRP>5.1 and DAS28-ESR>5.1 had only modest agreement (κ coefficients 0.45–0.54). Mean DAS28-CRP and DAS28-ESR were 5.7 and 6.2, respectively, in the ETN+MTX group (n=571), and 6.0 and 6.5 in the MTX group (n=262). A DAS28-CRP cut-off of 4.6 corresponded to a DAS28-ESR cut-off of 5.1. Conclusions We have shown that a DAS28-CRP of 4.6 corresponds to 5.1 for DAS28-ESR. Since this is substantially lower than the DAS28-ESR cut-off of 5.1, using 5.1 as the cut-off for DAS28-CRP underestimates disease activity in RA. Trial registration number NCT00195494; NCT00913458. PMID:28255449

  12. Dasty3, a WEB framework for DAS

    PubMed Central

    Villaveces, Jose M.; Jimenez, Rafael C.; Garcia, Leyla J.; Salazar, Gustavo A.; Gel, Bernat; Mulder, Nicola; Martin, Maria; Garcia, Alexander; Hermjakob, Henning

    2011-01-01

    Motivation: Dasty3 is a highly interactive and extensible Web-based framework. It provides a rich Application Programming Interface upon which it is possible to develop specialized clients capable of retrieving information from DAS sources as well as from data providers not using the DAS protocol. Dasty3 provides significant improvements on previous Web-based frameworks and is implemented using the 1.6 DAS specification. Availability: Dasty3 is an open-source tool freely available at http://www.ebi.ac.uk/dasty/ under the terms of the GNU General public license. Source and documentation can be found at http://code.google.com/p/dasty/. Contact: hhe@ebi.ac.uk PMID:21798964

  13. GHRSST-14 DAS-TAG Report

    NASA Technical Reports Server (NTRS)

    Armstrong, Edward; Piolle, Jean Francois

    2013-01-01

    The DAS-TAG provides the informatics and data management expertise in emerging information technologies for the GHRSST community. It provides expertise in data and metadata formats and standards, fosters improvements for GHRSST data curation, experiments with new data processing paradigms, and evaluates services and tools for data usage. It provides a forum for producer and distributor data management issues and coordination.

  14. Physik gestern und heute Das Eiskalorimeter

    NASA Astrophysics Data System (ADS)

    Heering, P.

    2003-07-01

    Kalorimetrische Messungen gehören heute zum experimentellen Standardrepertoire im Bereich der Thermodynamik und der physikalischen Chemie. Das erste Gerät für derartige Messungen entwickelten Ende des 18. Jahrhunderts die französischen Wissenschaftler Antoine Laurent Lavoisier und Pierre Simon de Laplace.

  15. GHRSST-14 DAS-TAG Report

    NASA Technical Reports Server (NTRS)

    Armstrong, Edward; Piolle, Jean Francois

    2013-01-01

    The DAS-TAG provides the informatics and data management expertise in emerging information technologies for the GHRSST community. It provides expertise in data and metadata formats and standards, fosters improvements for GHRSST data curation, experiments with new data processing paradigms, and evaluates services and tools for data usage. It provides a forum for producer and distributor data management issues and coordination.

  16. Moisture Forecast Bias Correction in GEOS DAS

    NASA Technical Reports Server (NTRS)

    Dee, D.

    1999-01-01

    Data assimilation methods rely on numerous assumptions about the errors involved in measuring and forecasting atmospheric fields. One of the more disturbing of these is that short-term model forecasts are assumed to be unbiased. In case of atmospheric moisture, for example, observational evidence shows that the systematic component of errors in forecasts and analyses is often of the same order of magnitude as the random component. we have implemented a sequential algorithm for estimating forecast moisture bias from rawinsonde data in the Goddard Earth Observing System Data Assimilation System (GEOS DAS). The algorithm is designed to remove the systematic component of analysis errors and can be easily incorporated in an existing statistical data assimilation system. We will present results of initial experiments that show a significant reduction of bias in the GEOS DAS moisture analyses.

  17. PoroTomo: DAS Vibroseis Data

    DOE Data Explorer

    Kurt Feigl

    2016-03-25

    The submitted data correspond to the monitored vibrations caused by a vibroseis seismically exciting the ground in the vertical direction and captured by the DAS horizontal and vertical arrays during the PoroTomo Experiment. The data also include a file with the acceleration record at the Vibroseis. Vibroseis Sweep Details: Sweep on location T84 Stage 4 (Mode P 60 s long record ) Time: 2016-03-25 14:01:15 (UTC) Location: 39.80476089N, -119.0027625W Elevation: 1272.0M (on ground surface at the site) Sweep length: 20 seconds Frequencies: 5 Hz to 20 Hz

  18. Das CARNOTsche Paradigma und seine erkenntnistheoretischen Implikationen

    NASA Astrophysics Data System (ADS)

    Schöpf, Hans-Georg

    Der vorliegende historisch-kritische Essay führt die Eigentümlichkeiten der klassischen phänomenologischen Thermodynamik auf das von CARNOT geschaffene Paradigma zurück und greift einige damit zusammenhängende Fragen auf.Translated AbstractCARNOT's Paradigm and its Epistemological ImplicationsThe present historic-critical essay traces the pecularities of classical phenomenological thermodynamics back to the paradigm, created by CARNOT, and takes up some questions to which this paradigm gives rise.

  19. Histochemistry of Centroorhynchus falconis (Das, 1950).

    PubMed

    Rengaraju, V; Das, E N

    1976-01-01

    With a view to augment the understanding of the animal mucosubstances in general and Acanthocephalan mucosubstances in particular, Acanthocephalan worms of (Centrorhynchus falconis, Das, 1950) were investigated histochemically by employing recent techniques. Variations in the intensity of histochemical reactions in different tissues revealed a heterogenous distribution of mucosubstances. The cuticle contained a mixture of periodate reactive neutral mucosubstances and sulfomucins, whereas the subcuticle contained only glycogen. Retractor muscles contained glycogen together with some acidic mucosubstances which exhibited alcianophilia only at high pH. Cement glands elaborated a mixture of glycogen and galactogen. Histochemical methods revealed two types of acanthors: Some contained only glycogen, whereas others contained glycogen and galactogen.

  20. PoroTomo Project - Subatask 6.2: Deploy and Operate DAS and DTS arrays - DAS Earthquake Data

    DOE Data Explorer

    Kurt Feigl

    2016-03-21

    The submitted data correspond to the vibration caused by a 3.4 M earthquake and captured by the DAS horizontal and vertical arrays during the PoroTomo Experiment. Earthquake information : M 4.3 - 23km ESE of Hawthorne, Nevada Time: 2016-03-21 07:37:10 (UTC) Location: 38.479°N 118.366°W Depth: 9.9 km Files for horizontal DAS array (each file is 30 s long and contain 8700 channels): PoroTomo_iDAS16043_160321073721.sgy PoroTomo_iDAS16043_160321073751.sgy Files for vertical DAS Array (each file is 30 s long and contain 380 channels): PoroTomo_iDAS025_160321073717.sgy PoroTomo_iDAS025_160321073747.sgy

  1. "Das Konkrete ist das Abstrakte, an das man sich schließlich gewöhnt hat." (Laurent Schwartz) Über den Ablauf des mathematischen Verstehens

    NASA Astrophysics Data System (ADS)

    Lowsky, Martin

    Die im Titel genannte Aussage findet sich in den Lebenserinnerungen von Laurent Schwartz (1915-2002), einem der fruchtbarsten Mathematiker, Mitglied der Gruppe Bourbaki. Im Original lautet die Aussage: "un objet concret est un objet abstrait auquel on a fini par s'habituer." Schwartz erläutert sie am Beispiel des Integrals über {e^{-1/2{x^2}}} , das den Wert Wurzel aus 2π hat und in dem sich also die Zahlen e und π verknüpfen. Was Schwartz aber vor allem ausdrücken will, ist dies: Das mathematische Verständnisd geht langsam vor sich und es bedarf der Anstrengung. "Es ist eine Frage der Zeit und der Energie", sagt Schwartz, und gerade dies mache es so schwer, die höhere Mathematik unter das Volk zu bringen. Das Lernen und Lehren von Mathematik laufe eben mühevoll und langsam ab.

  2. Pedagogical Basis of DAS Formalism in Engineering Education

    ERIC Educational Resources Information Center

    Hiltunen, J.; Heikkinen, E.-P.; Jaako, J.; Ahola, J.

    2011-01-01

    The paper presents a new approach for a bachelor-level curriculum structure in engineering. The approach is called DAS formalism according to its three phases: description, analysis and synthesis. Although developed specifically for process and environmental engineering, DAS formalism has a generic nature and it could also be used in other…

  3. Evidence of Motor Programming Deficits in Children Diagnosed with DAS.

    ERIC Educational Resources Information Center

    Nijland, Lian; Maassen, Ben; van der Meulen, Sjoeke

    2003-01-01

    Five children with developmental apraxia of speech (DAS), 5 controls (ages 5-6), and 6 adults produced utterances in a normal condition and in a bite-block condition in which the mandible was in a fixed position. In children with DAS, the bite-block had large effects on coarticulatory patterns and vowel quality. (Contains references.) (Author/CR)

  4. Pedagogical Basis of DAS Formalism in Engineering Education

    ERIC Educational Resources Information Center

    Hiltunen, J.; Heikkinen, E.-P.; Jaako, J.; Ahola, J.

    2011-01-01

    The paper presents a new approach for a bachelor-level curriculum structure in engineering. The approach is called DAS formalism according to its three phases: description, analysis and synthesis. Although developed specifically for process and environmental engineering, DAS formalism has a generic nature and it could also be used in other…

  5. Twenty‐eight‐joint counts invalidate the DAS28 remission definition owing to the omission of the lower extremity joints: a comparison with the original DAS remission

    PubMed Central

    Landewé, R; van der Heijde, D; van der Linden, S; Boers, M

    2006-01-01

    Objective To compare 28 joint disease activity score (DAS28) remission with comprehensive joint count DAS remission in rheumatoid arthritis. Methods 620 actually measured paired observations of DAS28 and DAS were analysed in 155 patients. Discordant observations (either DAS or DAS28 below remission cut off level: 1.6 for DAS and 2.6 for DAS28) and concordant observations (both DAS and DAS28 below their remission cut off level) were analysed separately. Results 91 of 620 paired DAS observations (15%) were discordant; 87 (in 53 patients) comprised observations in which the DAS28 remission criterion, but not the DAS remission criterion, was met. The reverse was found in only four observations, which were therefore omitted. With the original DAS as standard, DAS28 sensitivity was 95% and specificity 84%. Probability plots showed a swollen joint count >0 in 75% of discordant pairs v 48% of concordant pairs. The same was found for total joint count (TJC >0 in 90% v 40%; median TJC, 0 v 6) and patient global assessment, but not for ESR. Individual joint analysis showed that 51% of discordant v 18% of concordant observations (p<0.0005) had involvement of lower extremity joints that are not included in the DAS28. Conclusions DAS remission is more conservative than DAS28 remission. Activity (tenderness and swelling) in joints not included in the reduced joint counts (ankles, feet) mainly account for the discrepancy between the two assessments. DAS28 remission at a cut off level of 2.6 has insufficient construct validity and should be used with caution in clinical practice and clinical trials. PMID:16219709

  6. DAS: A Data Management System for Instrument Tests and Operations

    NASA Astrophysics Data System (ADS)

    Frailis, M.; Sartor, S.; Zacchei, A.; Lodi, M.; Cirami, R.; Pasian, F.; Trifoglio, M.; Bulgarelli, A.; Gianotti, F.; Franceschi, E.; Nicastro, L.; Conforti, V.; Zoli, A.; Smart, R.; Morbidelli, R.; Dadina, M.

    2014-05-01

    The Data Access System (DAS) is a and data management software system, providing a reusable solution for the storage of data acquired both from telescopes and auxiliary data sources during the instrument development phases and operations. It is part of the Customizable Instrument WorkStation system (CIWS-FW), a framework for the storage, processing and quick-look at the data acquired from scientific instruments. The DAS provides a data access layer mainly targeted to software applications: quick-look displays, pre-processing pipelines and scientific workflows. It is logically organized in three main components: an intuitive and compact Data Definition Language (DAS DDL) in XML format, aimed for user-defined data types; an Application Programming Interface (DAS API), automatically adding classes and methods supporting the DDL data types, and providing an object-oriented query language; a data management component, which maps the metadata of the DDL data types in a relational Data Base Management System (DBMS), and stores the data in a shared (network) file system. With the DAS DDL, developers define the data model for a particular project, specifying for each data type the metadata attributes, the data format and layout (if applicable), and named references to related or aggregated data types. Together with the DDL user-defined data types, the DAS API acts as the only interface to store, query and retrieve the metadata and data in the DAS system, providing both an abstract interface and a data model specific one in C, C++ and Python. The mapping of metadata in the back-end database is automatic and supports several relational DBMSs, including MySQL, Oracle and PostgreSQL.

  7. Pedagogical basis of DAS formalism in engineering education

    NASA Astrophysics Data System (ADS)

    Hiltunen, J.; Heikkinen, E.-P.; Jaako, J.; Ahola, J.

    2011-03-01

    The paper presents a new approach for a bachelor-level curriculum structure in engineering. The approach is called DAS formalism according to its three phases: description, analysis and synthesis. Although developed specifically for process and environmental engineering, DAS formalism has a generic nature and it could also be used in other engineering fields. The motivation for this new curriculum structure originates from the urge to solve the problems that engineering education has faced during the past decades, e.g. student recruitment problems and dissatisfactory learning outcomes. The focus of this paper is on the structure of the curriculum but the content is also discussed when it has an effect on the structure and its implementation. The presented structure, i.e. DAS formalism, builds upon the ideas of some classical pedagogical theories, which have regularly been applied at course level but seldom used to solve curriculum-level issues.

  8. Vallabhaneni Sita Rama Das, 1933-2010: teacher and mentor.

    PubMed

    Elchuri, Sailaja V; Govindjee

    2016-05-01

    We present here the life and research of V. S. Rama Das, a distinguished Indian botanist who specialized in photosynthesis. He was the first to purify chloroplasts that were free of mitochondrial contamination. He then studied C4, C3-C4 intermediate and CAM pathways, as well as their taxonomic distribution in tropical climates. His most valuable legacy is that he, as a philosopher, inspired and guided many students to pursue their research career in India. Also see Narayana and Pullaiah (Eminent Indian Botanists: Past and present: Biographies and contributions, pp 394-401, 2010) and Raghavendra and Reddy (Curr Sci 101:798-799, 2011) for further information on Rama Das.

  9. The development of the disease activity score (DAS) and the disease activity score using 28 joint counts (DAS28).

    PubMed

    van Riel, P L C M

    2014-01-01

    In rheumatoid arthritis, disease activity cannot be measured using a single variable. The Disease Activity Score (DAS) has been developed as a quantitative index to be able to measure, study and manage disease activity in RA in daily clinical practice, clinical trials, and long term observational studies. The DAS is a continuous measure of RA disease activity that combines information from swollen joints, tender joints, acute phase response and patient self-report of general health. Cut points were developed to classify patients in remission, as well as low, moderate, and severe disease activity in the 1990s. DAS-based EULAR response criteria were primarily developed to be used in clinical trials to classify individual patients as non-, moderate, or good responders, depending on the magnitude of change and absolute level of disease activity at the conclusion of the test.

  10. ProServer: a simple, extensible Perl DAS server.

    PubMed

    Finn, Robert D; Stalker, James W; Jackson, David K; Kulesha, Eugene; Clements, Jody; Pettett, Roger

    2007-06-15

    The increasing size and complexity of biological databases has led to a growing trend to federate rather than duplicate them. In order to share data between federated databases, protocols for the exchange mechanism must be developed. One such data exchange protocol that is widely used is the Distributed Annotation System (DAS). For example, DAS has enabled small experimental groups to integrate their data into the Ensembl genome browser. We have developed ProServer, a simple, lightweight, Perl-based DAS server that does not depend on a separate HTTP server. The ProServer package is easily extensible, allowing data to be served from almost any underlying data model. Recent additions to the DAS protocol have enabled both structure and alignment (sequence and structural) data to be exchanged. ProServer allows both of these data types to be served. ProServer can be downloaded from http://www.sanger.ac.uk/proserver/ or CPAN http://search.cpan.org/~rpettett/. Details on the system requirements and installation of ProServer can be found at http://www.sanger.ac.uk/proserver/.

  11. On the Law of Inertia. Translation of: Ueber das Beharrungsgesetz

    NASA Astrophysics Data System (ADS)

    Lange, Ludwig

    2014-04-01

    This article is a translation of Ludwig Lange: "Ueber das Beharrungsgesetz" in: Berichte ueber Verhandlungen der Koenigl. Saechsischen Gesellschaft der Wissenschaften, math.-physik. Klasse (Leipzig, 1885), SS. 333-351. Translated by Herbert Pfister, Institut für Theoretische Physik, Universität Tübingen, Auf der Morgenstelle 14, 72076 Tübingen, Germany; herbert.pfister@uni-tuebingen.de. Kind assistance by Julian Barbour is acknowledged.

  12. Disease Activity Score 28 (DAS28) using C-reactive protein underestimates disease activity and overestimates EULAR response criteria compared with DAS28 using erythrocyte sedimentation rate in a large observational cohort of rheumatoid arthritis patients in Japan.

    PubMed

    Matsui, Toshihiro; Kuga, Yoshiaki; Kaneko, Atsushi; Nishino, Jinju; Eto, Yoshito; Chiba, Noriyuki; Yasuda, Masayuki; Saisho, Koichiro; Shimada, Kota; Tohma, Shigeto

    2007-09-01

    To compare disease activity and the improvement of disease activity evaluated between by Disease Activity Score 28 using erythrocyte sedimentation rate (DAS28-ESR) and by DAS28 using C-reactive protein (DAS28-CRP) in Japanese patients with rheumatoid arthritis (RA). Data from 3073 RA patients registered in the large cohort database (NinJa: National Database of Rheumatic Diseases by iR-net in Japan) of 2003 was used to calculate DAS28-ESR and DAS28-CRP and disease activities were evaluated. Improvements in disease activities were also evaluated according to the European League Against Rheumatism (EULAR) response criteria in 1482 RA patients whose DAS28-ESR and DAS28-CRP could be calculated from data for both 2002 and 2003. The mean value of DAS28-CRP (3.59, SD 1.25) was significantly smaller than that of mean DAS28-ESR (4.31, SD 1.32) (p < 0.0001). The number of patients who satisfied the criteria of remission was 297 (9.7%) in DAS28-ESR versus 705 (22.9%) in DAS28-CRP and the number of patients with high disease activity was 842 (27.4%) versus 357 (11.6%) for DAS28-ESR and DAS28-CRP, respectively; there was a significant difference between the two (p < 0.0001). Change of respective DAS28 was significantly correlated (DeltaDAS28-ESR -0.05, SD 1.14 versus DeltaDAS28-CRP -0.10, SD 1.10) (p < 0.0001); however, the number of "good response" patients was significantly different (p < 0.03) between DAS28-ESR (97 patients, 6.5%) and DAS28-CRP (136 patients, 9.2%). DAS28-CRP significantly underestimated disease activity and overestimated the improvement in disease activity compared with DAS28-ESR. DAS28-CRP should be evaluated using different criteria from that for DAS28-ESR.

  13. Statistical Quality Control of Moisture Data in GEOS DAS

    NASA Technical Reports Server (NTRS)

    Dee, D. P.; Rukhovets, L.; Todling, R.

    1999-01-01

    A new statistical quality control algorithm was recently implemented in the Goddard Earth Observing System Data Assimilation System (GEOS DAS). The final step in the algorithm consists of an adaptive buddy check that either accepts or rejects outlier observations based on a local statistical analysis of nearby data. A basic assumption in any such test is that the observed field is spatially coherent, in the sense that nearby data can be expected to confirm each other. However, the buddy check resulted in excessive rejection of moisture data, especially during the Northern Hemisphere summer. The analysis moisture variable in GEOS DAS is water vapor mixing ratio. Observational evidence shows that the distribution of mixing ratio errors is far from normal. Furthermore, spatial correlations among mixing ratio errors are highly anisotropic and difficult to identify. Both factors contribute to the poor performance of the statistical quality control algorithm. To alleviate the problem, we applied the buddy check to relative humidity data instead. This variable explicitly depends on temperature and therefore exhibits a much greater spatial coherence. As a result, reject rates of moisture data are much more reasonable and homogeneous in time and space.

  14. Statistical Quality Control of Moisture Data in GEOS DAS

    NASA Technical Reports Server (NTRS)

    Dee, D. P.; Rukhovets, L.; Todling, R.

    1999-01-01

    A new statistical quality control algorithm was recently implemented in the Goddard Earth Observing System Data Assimilation System (GEOS DAS). The final step in the algorithm consists of an adaptive buddy check that either accepts or rejects outlier observations based on a local statistical analysis of nearby data. A basic assumption in any such test is that the observed field is spatially coherent, in the sense that nearby data can be expected to confirm each other. However, the buddy check resulted in excessive rejection of moisture data, especially during the Northern Hemisphere summer. The analysis moisture variable in GEOS DAS is water vapor mixing ratio. Observational evidence shows that the distribution of mixing ratio errors is far from normal. Furthermore, spatial correlations among mixing ratio errors are highly anisotropic and difficult to identify. Both factors contribute to the poor performance of the statistical quality control algorithm. To alleviate the problem, we applied the buddy check to relative humidity data instead. This variable explicitly depends on temperature and therefore exhibits a much greater spatial coherence. As a result, reject rates of moisture data are much more reasonable and homogeneous in time and space.

  15. Einfluss des Internets auf das Informations-, Einkaufs- und Verkehrsverhalten

    NASA Astrophysics Data System (ADS)

    Nerlich, Mark R.; Schiffner, Felix; Vogt, Walter

    Mit Daten aus eigenen Erhebungen können das einkaufsbezogene Informations- und Einkaufsverhalten im Zusammenhang mit den verkehrlichen Aspekten (Distanzen, Verkehrsmittel, Wegekopplungen) dargestellt werden. Die Differenzierung in die drei Produktkategorien des täglichen, mittelfristigen und des langfristigen Bedarfs berücksichtigt in erster Linie die Wertigkeit eines Gutes, die seine Erwerbshäufigkeit unmittelbar bestimmt. Der Einsatz moderner IKT wie das Internet eröffnet dem Endverbraucher neue Möglichkeiten bei Information und Einkauf. Die verkehrliche Relevanz von Online-Shopping wird deutlich, wenn man berücksichtigt, dass im Mittel rund 17% aller Online-Einkäufe, die die Probanden durchgeführt haben, Einkäufe in Ladengeschäften ersetzen. Dies gilt in verstärktem Maße für Online-Informationen: etwa die Hälfte hätte alternativ im stationären Einzelhandel stattgefunden. Da der Erwerb von Gütern des täglichen Bedarfs häufig nahräumlich und in relevantem Anteil nicht-motorisiert erfolgen kann, sind in diesem Segment - im Gegensatz zum mittel- und langfristigen Bedarf - nur geringe Substitutionseffekte zu beobachten.

  16. M-DAS: System for multispectral data analysis. [in Saginaw Bay, Michigan

    NASA Technical Reports Server (NTRS)

    Johnson, R. H.

    1975-01-01

    M-DAS is a ground data processing system designed for analysis of multispectral data. M-DAS operates on multispectral data from LANDSAT, S-192, M2S and other sources in CCT form. Interactive training by operator-investigators using a variable cursor on a color display was used to derive optimum processing coefficients and data on cluster separability. An advanced multivariate normal-maximum likelihood processing algorithm was used to produce output in various formats: color-coded film images, geometrically corrected map overlays, moving displays of scene sections, coverage tabulations and categorized CCTs. The analysis procedure for M-DAS involves three phases: (1) screening and training, (2) analysis of training data to compute performance predictions and processing coefficients, and (3) processing of multichannel input data into categorized results. Typical M-DAS applications involve iteration between each of these phases. A series of photographs of the M-DAS display are used to illustrate M-DAS operation.

  17. M-DAS: System for multispectral data analysis. [in Saginaw Bay, Michigan

    NASA Technical Reports Server (NTRS)

    Johnson, R. H.

    1975-01-01

    M-DAS is a ground data processing system designed for analysis of multispectral data. M-DAS operates on multispectral data from LANDSAT, S-192, M2S and other sources in CCT form. Interactive training by operator-investigators using a variable cursor on a color display was used to derive optimum processing coefficients and data on cluster separability. An advanced multivariate normal-maximum likelihood processing algorithm was used to produce output in various formats: color-coded film images, geometrically corrected map overlays, moving displays of scene sections, coverage tabulations and categorized CCTs. The analysis procedure for M-DAS involves three phases: (1) screening and training, (2) analysis of training data to compute performance predictions and processing coefficients, and (3) processing of multichannel input data into categorized results. Typical M-DAS applications involve iteration between each of these phases. A series of photographs of the M-DAS display are used to illustrate M-DAS operation.

  18. Das Assessment von Vulnerabilitäten, Risiken und Unsicherheiten

    NASA Astrophysics Data System (ADS)

    Birkmann, Jörn; Greiving, Stefan; Serdeczny, Olivia Maria

    Die Risiken und möglichen Folgen des Klimawandels für Menschen, Produktions- und Ökosysteme sind eng mit sozioökonomischen Entwicklungen und Rahmenbedingungen verflochten. Die Schlüsselbegriffe "Vulnerabilität", "Risiko" und "Unsicherheit" werden näher beleuchtet, um u. a. deutlich zu machen, wie sie im neueren Risikoansatz des Fünften Sachstandsberichts (AR5) des Weltklimarats (IPCC) genutzt werden. Das Risikokonzept wird vom Vulnerabilitätskonzept unterschieden. In den Fokus rückt die Betrachtung von Gefahr und Exposition. Auch die Frage, was unter Unsicherheit und Bandbreiten möglicher Entwicklungen des Klimas und sogenannter sozioökonomischer Entwicklungspfade zu verstehen ist, spielt dabei eine wichtige Rolle. Bisherige Untersuchungsmethoden zu Risiken im Kontext des Klimawandels und darauf aufbauende Entscheidungsprozesse werden im Hinblick auf künftige Anpassungsmaßnahmen diskutiert.

  19. Das Semantic Web als Werkzeug in der biomedizinischen Forschung

    NASA Astrophysics Data System (ADS)

    Stenzhorn, Holger; Samwald, Matthias

    In der biomedizinischen Forschung werden besonders in den letzten Jahren vermehrt enorme Mengen an neuen Daten produziert und diese in Folge verstärkt per Internet veröffentlicht. Viele Experten sehen in dieser Vorgehensweise die Chance zur Entdeckung bisher unbekannter biomedizinischer Erkenntnisse. Um dies jedoch zu ermöglichen, müssen neue Wege gefunden werden, die gewonnenen Daten effizient zu verarbeiten und zu verwalten. In dem vorliegenden Artikel werden die Möglichkeiten betrachtet, die das Semantic Web hierzu anbieten kann. Hierfür werden die relevanten Technologien des Semantic Web im speziellen Kontext der biomedizinischen Forschung betrachtet. Ein Fokus liegt auf der Anwendung von Ontologien in der Biomedizin: Es wird auf deren Vorteile eingegangen, aber auch auf möglichen Probleme, die deren Einsatz in einem erweiterten wissenschaftlichen Umfeld mit sich bringen können.

  20. The Disease Activity Score (DAS) and the Disease Activity Score using 28 joint counts (DAS28) in the management of rheumatoid arthritis.

    PubMed

    van Riel, Piet L C M; Renskers, Lisanne

    2016-01-01

    In rheumatoid arthritis (RA), disease activity cannot be measured in all individual patients according to a single variable. The Disease Activity Score (DAS) and the DAS28 have been developed to measure disease activity in RA both in daily clinical practice as well as in clinical trials on a group as well as individual level. The DAS/DAS28 is a continuous measure of RA disease activity that combines information from swollen joints, tender joints, acute phase response and general health. The DAS-based EULAR response criteria were primarily developed to be used in clinical trials. The EULAR response criteria classify individual patients as non-, moderate, or good responders, dependent on the magnitude of change and level of disease activity reached. In addition, already in the early nineties, cut points were developed to categorise patients in remission. The DAS28 is incorporated in several electronic patient records and web-based systems for monitoring purposes in daily clinical practice. In addition to this, it is being used in combination with patient-reported outcome measures (PROMs) to facilitate self-monitoring.

  1. Detecting Changes Following the Provision of Assistive Devices: Utility of the WHO-DAS II

    ERIC Educational Resources Information Center

    Raggi, Alberto

    2010-01-01

    The World Health Organization Disability Assessment Schedule II (WHO-DAS II) is a non-disease-specific International Classification of Functioning, Disability, and Health-based disability assessment instrument developed to measure activity limitations and restrictions to participation. The aim of this pilot study is to evaluate WHO-DAS II…

  2. Psychometric Properties of the Disability Assessment Schedule (DAS) for Behavior Problems: An Independent Investigation

    ERIC Educational Resources Information Center

    Tsakanikos, Elias; Underwood, Lisa; Sturmey, Peter; Bouras, Nick; McCarthy, Jane

    2011-01-01

    The present study employed the Disability Assessment Schedule (DAS) to assess problem behaviors in a large sample of adults with ID (N = 568) and evaluate the psychometric properties of this instrument. Although the DAS problem behaviors were found to be internally consistent (Cronbach's [alpha] = 0.87), item analysis revealed one weak item…

  3. Detecting Changes Following the Provision of Assistive Devices: Utility of the WHO-DAS II

    ERIC Educational Resources Information Center

    Raggi, Alberto

    2010-01-01

    The World Health Organization Disability Assessment Schedule II (WHO-DAS II) is a non-disease-specific International Classification of Functioning, Disability, and Health-based disability assessment instrument developed to measure activity limitations and restrictions to participation. The aim of this pilot study is to evaluate WHO-DAS II…

  4. Psychometric Properties of the Disability Assessment Schedule (DAS) for Behavior Problems: An Independent Investigation

    ERIC Educational Resources Information Center

    Tsakanikos, Elias; Underwood, Lisa; Sturmey, Peter; Bouras, Nick; McCarthy, Jane

    2011-01-01

    The present study employed the Disability Assessment Schedule (DAS) to assess problem behaviors in a large sample of adults with ID (N = 568) and evaluate the psychometric properties of this instrument. Although the DAS problem behaviors were found to be internally consistent (Cronbach's [alpha] = 0.87), item analysis revealed one weak item…

  5. Das Programm Oder 2006. Hochwasserschutz in Polen im Zuge der EU-Osterweiterung

    NASA Astrophysics Data System (ADS)

    Kühne, Olaf

    Hochwasser ist ein natürliches Ereignis: Seit jeher sind die Menschen mit Hochwasser und seinen Auswirkungen konfrontiert. Das Ausmaß von Hochwasser reicht dabei von Straßenüberschwemmungen bis zur Überflutung ganzer Landesteile. Auch im Oderflußsystem waren und sind Überschwemmungen keine Seltenheit, in den letzten 200 Jahren ereigneten sie sich in den Jahren 1813, 1838, 1854, 1870, 1903, 1958, 1965, 1970, 1972, 1977, 1981, 1985 und 1997. Das Hochwasser von 1997 war jedoch das schwerste im genannten Zeitraum. Als Reaktion auf das Hochwasser von 1997 wurde in der betroffenen Region das Programm 〝Oder 2006`` entwickelt. Mit seiner Hilfe sollen die Auswirkungen künftiger Hochwasserereignisse abgeschwächt werden.

  6. Disease Activity Score 28 (DAS28) using C‐reactive protein underestimates disease activity and overestimates EULAR response criteria compared with DAS28 using erythrocyte sedimentation rate in a large observational cohort of rheumatoid arthritis patients in Japan

    PubMed Central

    Matsui, Toshihiro; Kuga, Yoshiaki; Kaneko, Atsushi; Nishino, Jinju; Eto, Yoshito; Chiba, Noriyuki; Yasuda, Masayuki; Saisho, Koichiro; Shimada, Kota; Tohma, Shigeto

    2007-01-01

    Objectives To compare disease activity and the improvement of disease activity evaluated between by Disease Activity Score 28 using erythrocyte sedimentation rate (DAS28‐ESR) and by DAS28 using C‐reactive protein (DAS28‐CRP) in Japanese patients with rheumatoid arthritis (RA). Methods Data from 3073 RA patients registered in the large cohort database (NinJa: National Database of Rheumatic Diseases by iR‐net in Japan) of 2003 was used to calculate DAS28‐ESR and DAS28‐CRP and disease activities were evaluated. Improvements in disease activities were also evaluated according to the European League Against Rheumatism (EULAR) response criteria in 1482 RA patients whose DAS28‐ESR and DAS28‐CRP could be calculated from data for both 2002 and 2003. Results The mean value of DAS28‐CRP (3.59, SD 1.25) was significantly smaller than that of mean DAS28‐ESR (4.31, SD 1.32) (p < 0.0001). The number of patients who satisfied the criteria of remission was 297 (9.7%) in DAS28‐ESR versus 705 (22.9%) in DAS28‐CRP and the number of patients with high disease activity was 842 (27.4%) versus 357 (11.6%) for DAS28‐ESR and DAS28‐CRP, respectively; there was a significant difference between the two (p < 0.0001). Change of respective DAS28 was significantly correlated (ΔDAS28‐ESR −0.05, SD 1.14 versus ΔDAS28‐CRP −0.10, SD 1.10) (p < 0.0001); however, the number of “good response” patients was significantly different (p < 0.03) between DAS28‐ESR (97 patients, 6.5%) and DAS28‐CRP (136 patients, 9.2%). Conclusions DAS28‐CRP significantly underestimated disease activity and overestimated the improvement in disease activity compared with DAS28‐ESR. DAS28‐CRP should be evaluated using different criteria from that for DAS28‐ESR. PMID:17369281

  7. How to specify and measure sensitivity in Distributed Acoustic Sensing (DAS)?

    NASA Astrophysics Data System (ADS)

    Gabai, Haniel; Eyal, Avishay

    2017-04-01

    In Rayleigh-scattering-based Distributed Acoustic Sensing (DAS) an optical fiber is transformed into an array of thousands of 'virtual microphones'. This approach has gained tremendous popularity in recent years and is one of the most successful examples of a fiber-optic sensing method which made its way from the academia to the market. Despite the great amount of work done in this field, sensitivity, which is ones of the most critical parameters of any sensing technique, was rarely investigated in this context. In particular, little attention was given to its random characteristics. Without careful consideration of the random aspects of DAS, any attempt to specify its sensitivity or to compare between different DAS modalities is of limited value. Recently we introduced a new statistical parameter which defines DAS sensitivity and enables comparison between the performances of different DAS systems. In this paper we generalize the previous parameter and give a broader, simple and intuitive definition to DAS sensitivity. An important attribute of these parameters is that they can be easily extracted from the static backscatter profile of the sensing fiber. In the paper we derive the relation between DAS sensitivity and the static backscatter profile and present an experimental verification of this relation.

  8. DasR positively controls monensin production at two-level regulation in Streptomyces cinnamonensis.

    PubMed

    Zhang, Yue; Lin, Chun-Yan; Li, Xiao-Mei; Tang, Zheng-Kun; Qiao, Jianjun; Zhao, Guang-Rong

    2016-12-01

    The polyether ionophore antibiotic monensin is produced by Streptomyces cinnamonensis and is used as a coccidiostat for chickens and growth-promoting agent for cattle. Monensin biosynthetic gene cluster has been cloned and partially characterized. The GntR-family transcription factor DasR regulates antibiotic production and morphological development in Streptomyces coelicolor and Saccharopolyspora erythraea. In this study, we identified and characterized the two-level regulatory cascade of DasR to monensin production in S. cinnamonensis. Forward and reverse genetics by overexpression and antisense RNA silence of dasR revealed that DasR positively controls monensin production under nutrient-rich condition. Electrophoresis mobility shift assay (EMSA) showed that DasR protein specifically binds to the promoter regions of both pathway-specific regulatory gene monRII and biosynthetic genes monAIX, monE and monT. Semi-quantitative RT-PCR further confirmed that DasR upregulates the transcriptional levels of these genes during monensin fermentation. Subsequently, co-overexpressed dasR with pathway-specific regulatory genes monRI, monRII or monH greatly improved monensin production.

  9. Crosslinking effect of dialdehyde starch (DAS) on decellularized porcine aortas for tissue engineering.

    PubMed

    Wang, Xu; Gu, Zhipeng; Qin, Huanhuan; Li, Li; Yang, Xu; Yu, Xixun

    2015-08-01

    Biological tissue-derived biomaterials must be chemically modified to avoid immediate degradation and immune response before being implanted in human body to replace malfunctioning organs. DAS with active aldehyde groups was employed to replace glutaraldehyde (GA), a most common synthetic crosslinking reagent in clinical practice, to fix bioprostheses for lower cytotoxicity. The aim of this research was to evaluate fixation effect of DAS. The tensile strength, crosslinking stability, cytotoxicity especially the anti-calcification capability of DAS-fixed tissues were investigated. The tensile strength and resistance to enzymatic degradation of samples were increased after DAS fixation, the values maintained stably in D-Hanks solution for several days. Meanwhile, ultrastructure of samples preserved well and the anti-calcification capability of samples were improved, the amount of positive staining points in the whole visual field of 15% DAS-fixed samples was only 0.576 times to GA-fixed ones. Moreover, both unreacted DAS and its hydrolytic products were nontoxic in cytotoxicity study. The results demonstrated DAS might be an effective crosslinking reagent to fix biological tissue-derived biomaterials in tissue engineering. Copyright © 2015 Elsevier B.V. All rights reserved.

  10. Compositional safety of herbicide-tolerant DAS-81910-7 cotton.

    PubMed

    Herman, Rod A; Fast, Brandon J; Johnson, Tempest Y; Sabbatini, Jane; Rudgers, Gary W

    2013-11-27

    DAS-81910-7 cotton is a transgenic event that was transformed to contain the aad-12 and pat genes. These genes code for the AAD-12 and PAT proteins, which confer tolerance to the herbicides 2,4-D and glufosinate, respectively. Crop composition studies were conducted with DAS-81910-7 cotton (both nonsprayed and sprayed with 2,4-D and glufosinate) to comply with requirements of regulatory authorities responsible for evaluating crop safety. Results indicate compositional equivalence between DAS-81910-7 cottonseed and nontransgenic cottonseed and between sprayed and nonsprayed DAS-81910-7 cottonseed. This study builds on the results from many prior studies which support the conclusion that transgenesis is less likely to unexpectedly alter the composition of crops as compared with traditional breeding.

  11. Phase 1 Clinical Trials of DAS181, an Inhaled Sialidase, in Healthy Adults

    PubMed Central

    Zenilman, Jonathan M.; Fuchs, Edward J.; Hendrix, Craig W.; Radebaugh, Christine; Jurao, Robert; Nayak, Seema U.; Hamilton, Robert G.; Griffiss, J. McLeod

    2015-01-01

    DAS181, (study drug, Fludase®) was developed for treatment of influenza and parainfluenza infections. Delivered by inhalation, DAS181 cleaves sialic acid receptors from respiratory epithelial cells. Treatment of influenza for three days with DAS181 reduced viral shedding. To increase deposition in the upper airways and decrease systemic absorption, the particle size was increased to 10 microns. We conducted two Phase I trials with three cohorts, randomized 2:1, active drug to placebo. The initial cohort got a single 20 mg dose of DAS181, or placebo; the second, 20 mg DAS181 or placebo for 10 days, and the third got 20 mg of DAS181or placebo for 3 days. Formulations differed slightly in their excipients. Subjects in the 1- and 3-day cohorts completed dosing without serious adverse events. Two subjects in the 10-day cohort stopped at Day 9 after developing respiratory and systemic symptoms, and a third experienced a decrease in FEV1 (Forced Expiratory Volume in 1 second) after the 9th dose and a further decline after the 10th dose. Plasma DAS181, in the 10-day cohort, peaked and began falling before the last dose. Antibodies, predominately IgG with neutralizing activity, were detected in 15/18 subjects by Day 30. The highest IgG concentrations were in the 10-day cohort. The respiratory adverse events occurring after seven days and rapid drug clearance during continued dosing are consistent with the induction of DAS181 antibodies. This could preclude use of this medication for longer than seven days or for repeated courses. (These studies have been registered at ClinicalTrials.gov under registration nos. NCT 00527865 and NCT 01651494.) PMID:26391974

  12. Phase 1 clinical trials of DAS181, an inhaled sialidase, in healthy adults.

    PubMed

    Zenilman, Jonathan M; Fuchs, Edward J; Hendrix, Craig W; Radebaugh, Christine; Jurao, Robert; Nayak, Seema U; Hamilton, Robert G; McLeod Griffiss, J

    2015-11-01

    DAS181, (study drug, Fludase®) was developed for treatment of influenza and parainfluenza infections. Delivered by inhalation, DAS181 cleaves sialic acid receptors from respiratory epithelial cells. Treatment of influenza for three days with DAS181 reduced viral shedding. To increase deposition in the upper airways and decrease systemic absorption, the particle size was increased to 10μm. We conducted two Phase I trials with three cohorts, randomized 2:1, active drug to placebo. The initial cohort got a single 20mg dose of DAS181, or placebo; the second, 20mg DAS181 or placebo for 10days, and the third got 20mg of DAS181 or placebo for 3days. Formulations differed slightly in their excipients. Subjects in the 1- and 3-day cohorts completed dosing without serious adverse events. Two subjects in the 10-day cohort stopped at Day 9 after developing respiratory and systemic symptoms, and a third experienced a decrease in FEV1 (Forced Expiratory Volume in 1s) after the 9th dose and a further decline after the 10th dose. Plasma DAS181, in the 10-day cohort, peaked and began falling before the last dose. Antibodies, predominately IgG with neutralizing activity, were detected in 15/18 subjects by Day 30. The highest IgG concentrations were in the 10-day cohort. The respiratory adverse events occurring after seven days and rapid drug clearance during continued dosing are consistent with the induction of DAS181 antibodies. This could preclude use of this medication for longer than seven days or for repeated courses. (These studies have been registered at ClinicalTrials.gov under registration Nos. NCT 00527865 and NCT 01651494.).

  13. Development of a Driver Alert System (DAS) for the Bradley Fighting Vehicle

    DTIC Science & Technology

    1988-07-01

    FIGHTING VEHICLE The survivability of a Bradley Fighting Vehicle (BFV) depends, in large part, on rapid response and movement in changing battle conditions...ARI Research Note 88-73 I6 0 Development of aDriver AertSystem CO (DAS) for the Bradley Fighting Vehicle * David F. Champion, Paul R. Roberson, and...System (DAS) Final Report for the Bradley Fighting Vehicle September 85 - September 87 6. PERFORMING ORG. REPORT NUMBER 7. AUTHOR(s) 6. CONTRACT OR GRANT

  14. VIIRS ocean color data visualization and processing with IDL-based NOAA-SeaDAS

    NASA Astrophysics Data System (ADS)

    Wang, Xiaolong; Liu, Xiaoming; Jiang, Lide; Wang, Menghua; Sun, Junqiang

    2014-11-01

    The NOAA Sea-viewing Data Analysis System (NOAA-SeaDAS) is an Interactive Data Language (IDL)-based satellite data visualization, analysis, and processing system based on the version 6.4 of the NASA's Sea-viewing Wide Field-ofview (SeaWiFS) Data Analysis System (SeaDAS) released in 2012. NOAA-SeaDAS inherited all the original functionalities of SeaDAS 6.4 and was upgraded with many new functions and new sensor supports, particularly the support of the Visible Infrared Imaging Radiometer Suite (VIIRS) onboard the Suomi National Polar-Orbiting Partnership (SNPP). The main goal of the NOAA-SeaDAS development is primarily in support of NOAA ocean color team's calibration and validation activities. The current version of NOAA-SeaDAS can visualize, analyze, and process VIIRS Sensor Data Records (SDR or Level-1B data) produced by the NOAA Interface Data Processing System (IDPS), ocean color Environmental Data Records (EDR or Level-2 data) produced by the NOAA Multi-Sensor Level-1 to Level- 2 (MSL12) ocean color data processing system, and Level-3 data binned or mapped from Level-2 data produced by NOAA-MSL12. NOAA-SeaDAS is currently serving an active IDL user group at NOAA and will serve other institutions and universities in the future. The goal is to allow various scientific users to visualize, analyze, and process VIIRS data from Level-1B through Level-2 and Level-3. In addition, NOAA-SeaDAS can also visualize satellite images from the Korean Geostationary Ocean Color Imager (GOCI), as well as many other satellite ocean color sensors, e.g., SeaWiFS, the Moderate Resolution Imaging Spectroradiometer (MODIS), etc. NOAA-SeaDAS is under constant development to create new system functionalities and enhance user experience. With constantly increasing volume in the global ocean color data archive, NOAA-SeaDAS will play an important role in support of global marine environment data analysis and various scientific applications.

  15. Inhibition of neuraminidase inhibitor-resistant influenza virus by DAS181, a novel sialidase fusion protein.

    PubMed

    Triana-Baltzer, Gallen B; Gubareva, Larisa V; Klimov, Alexander I; Wurtman, David F; Moss, Ronald B; Hedlund, Maria; Larson, Jeffrey L; Belshe, Robert B; Fang, Fang

    2009-11-06

    Antiviral drug resistance for influenza therapies remains a concern due to the high prevalence of H1N1 2009 seasonal influenza isolates which display H274Y associated oseltamivir-resistance. Furthermore, the emergence of novel H1N1 raises the potential that additional reassortments can occur, resulting in drug resistant virus. Thus, additional antiviral approaches are urgently needed. DAS181 (Fludase), a sialidase fusion protein, has been shown to have inhibitory activity against a large number of seasonal influenza strains and a highly pathogenic avian influenza (HPAI) strain (H5N1). Here, we examine the in vitro activity of DAS181 against a panel of 2009 oseltamivir-resistant seasonal H1N1 clinical isolates. The activity of DAS181 against nine 2009, two 2007, and two 2004 clinical isolates of seasonal IFV H1N1 was examined using plaque number reduction assay on MDCK cells. DAS181 strongly inhibited all tested isolates. EC50 values remained constant against isolates from 2004, 2007, and 2009, suggesting that there was no change in DAS181 sensitivity over time. As expected, all 2007 and 2009 isolates were resistant to oseltamivir, consistent with the identification of the H274Y mutation in the NA gene of all these isolates. Interestingly, several of the 2007 and 2009 isolates also exhibited reduced sensitivity to zanamivir, and accompanying HA mutations near the sialic acid binding site were observed. DAS181 inhibits IFV that is resistant to NAIs. Thus, DAS181 may offer an alternative therapeutic option for seasonal or pandemic IFVs that become resistant to currently available antiviral drugs.

  16. BOOK REVIEW: Geheimnisvolles Universum - Europas Astronomen entschleiern das Weltall

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Lorenzen, D. H.

    2002-12-01

    The 25th birthday of ESO, in 1987, was celebrated by the publication of an illustrated popular book, "Exploring the Southern Sky" (Springer-Verlag 1987), which also saw editions in Danish, English, French, German, and Spanish. Written and illustrated by the ESO staff members Svend Laustsen, Claus Madsen and Richard M. West, its many pictures were mainly taken with the ESO 3.6m and Schmidt telescopes. The structure of the book - perhaps at that time somewhat unusual - started with things far away (Universe and galaxies), zoomed in to the Milky Way, and finally reached the Solar System (with a concluding chapter dealing with the La Silla observatory). Now, with the 4 units of the Very Large Telescope in full operation, and on the occasion of ESO's 40th birthday, another jubilee book has appeared: "Geheimnisvolles Universum: Europas Astronomen entschleiern das Weltall", written by the science journalist Dirk H. Lorenzen, of Hamburg, Germany, and prefaced by Catherine Cesarsky, Director General of ESO. Presumably, this book will also soon become available in more languages spoken in ESO member countries. Thus it may be worthwhile to review the first edition, although some readers may like to wait for more easily accessible editions. Before going into details, let me first mention that I find this a very impressing book, great to look at and refreshing to read. With ESO seen through the eyes of a visitor, things gain a perspective that is quite different from that of the previous book, and at least as attractive. It comes as no surprise that the book starts with a visit of ESO's showcase, the Paranal Observatory, and the writer not only notes down his own impressions, but also cites statements of some of the many people that keep Paranal going - technicians and staff astronomers. This mixture of texts provides a good impression of the operations at a large observatory for the general reader. The two more 'astronomical' parts that follow deal with star and planet

  17. Global Gridded Data from the Goddard Earth Observing System Data Assimilation System (GEOS-DAS)

    NASA Technical Reports Server (NTRS)

    2001-01-01

    The Goddard Earth Observing System Data Assimilation System (GEOS-DAS) timeseries is a globally gridded atmospheric data set for use in climate research. This near real-time data set is produced by the Data Assimilation Office (DAO) at the NASA Goddard Space Flight Center in direct support of the operational EOS instrument product generation from the Terra (12/1999 launch), Aqua (05/2002 launch) and Aura (01/2004 launch) spacecrafts. The data is archived in the EOS Core System (ECS) at the Goddard Earth Sciences Data and Information Services Center/Distributed Active Archive Center (GES DISC DAAC). The data is only a selection of the products available from the GEOS-DAS. The data is organized chronologically in timeseries format to facilitate the computation of statistics. GEOS-DAS data will be available for the time period January 1, 2000, through present.

  18. Amerikas Einschätzung der deutschen Atomforschung: Das deutsche Uranprojekt

    NASA Astrophysics Data System (ADS)

    Walker, Mark

    2002-07-01

    Die amerikanischen Wissenschaftler und ihre emigrierten Kollegen, die am Bau der Atombombe beteiligt waren, verfügten über sehr widersprüchliche und großteils falsche Informationen über den Fortschritt des deutschen Uranprogramms. Noch nach Kriegsende lässt sich dies an Aussagen des Leiters der amerikanischen Alsos-Mission, Samuel Goudsmit, festmachen. Tatsächlich war das deutsche Programm hinsichtlich seiner wissenschaftlichen Grundlagen und des Managements nicht so unterlegen, wie vielfach behauptet wurde. Aber die deutschen Behörden waren nicht in der Lage, Geld und Ressourcen in gleichem Maße in das Uranprojekt zu investieren, wie etwa in das Peenemünder Raketenprojekt.

  19. DasR is a pleiotropic regulator required for antibiotic production, pigment biosynthesis, and morphological development in Saccharopolyspora erythraea.

    PubMed

    Liao, Cheng-Heng; Xu, Ya; Rigali, Sébastien; Ye, Bang-Ce

    2015-12-01

    The GntR-family transcription regulator, DasR, was previously identified as pleiotropic, controlling the primary amino sugar N-acetylglucosamine (GlcNAc) and chitin metabolism in Saccharopolyspora erythraea and Streptomyces coelicolor. Due to the remarkable regulatory impact of DasR on antibiotic production and development in the model strain of S. coelicolor, we here identified and characterized the role of DasR to secondary metabolite production and morphological development in industrial erythromycin-producing S. erythraea. The physiological studies have shown that a constructed deletion of dasR in S. erythraea resulted in antibiotic, pigment, and aerial hyphae production deficit in a nutrient-rich condition. DNA microarray assay, combined with quantitative real-time reverse transcription PCR (qRT-PCR), confirmed these results by showing the downregulation of the genes relating to secondary metabolite production in the dasR null mutant. Notably, electrophoretic mobility shift assays (EMSA) showed DasR as being the first identified regulator that directly regulates the pigment biosynthesis rpp gene cluster. In addition, further studies indicated that GlcNAc, the major nutrient signal of DasR-responsed regulation, blocked secondary metabolite production and morphological development. The effects of GlcNAc were shown to be caused by DasR mediation. These findings demonstrated that DasR is an important pleiotropic regulator for both secondary metabolism and morphological development in S. erythraea, providing new insights for the genetic engineering of S. erythraea with increased erythromycin production.

  20. Psychometric properties of the Death Anxiety Scale (DAS) among terminally ill cancer patients.

    PubMed

    Royal, Kenneth D; Elahi, Fereshte

    2011-01-01

    Research conducted with the terminally ill population in relation to death anxiety is rare and mostly outdated. The purpose of this study was to evaluate the psychometric properties of the widely used Death Anxiety Scale (DAS) on a sample of terminal cancer patients.Additionally, validation studies of the DAS have exclusively used traditional statistical methods for analysis. The current study utilized an item response theory technique (IRT), namely the Rasch Rating Scale model for data analysis. The methodology employed may be useful for other researchers conducting validation studies from an IRT perspective.

  1. PoroTomo: Map of DAS, Nodal, Vibroseis and Reftek Station Deployment

    SciTech Connect

    Kurt Feigl

    2016-10-15

    Map of DAS, nodal, vibroseis and Reftek stations during March 2016 deployment. The plot on the left has nodal stations labeled; the plot on the right has vibroseis observations labeled. Stations are shown in map-view using Brady's rotated X-Y coordinates with side plots denoting elevation with respect to the WGS84 ellipsoid. Blue circles denote vibroseis data, x symbols denote DAS (cyan for horizontal and magenta for vertical), black asterisks denote Reftek data, and red plus signs denote nodal data. This map can be found on UW-Madison's askja server at /PoroTomo/DATA/MAPS/Deployment_Stations.pdf

  2. The Deaf Acculturation Scale (DAS): Development and Validation of a 58-Item Measure

    PubMed Central

    Maxwell-McCaw, Deborah; Zea, Maria Cecilia

    2011-01-01

    This study involved the development and validation of the Deaf Acculturation Scale (DAS), a new measure of cultural identity for Deaf and hard-of-hearing (hh) populations. Data for this study were collected online and involved a nation-wide sample of 3,070 deaf/hh individuals. Results indicated strong internal reliabilities for all the subscales, and construct validity was established by demonstrating that the DAS could discriminate groups based on parental hearing status, school background, and use of self-labels. Construct validity was further demonstrated through factorial analyses, and findings resulted in a final 58-item measure. Directions for future research are discussed. PMID:21263041

  3. Das Lob der Sternkunst. Astronomie in der deutschen Aufklärung.

    NASA Astrophysics Data System (ADS)

    Baasner, R.

    Contents: 1. Einleitung. 2. Die Astronomie im Rahmen der Aufklärungs-Physik. 3. Das Lob der Sternkunst. 4. Ein Blick auf die Sternwarten. 5. Allgemeine Darstellungen der Sternkunde. 6. Schleppende Rezeption: Das kopernikanische Weltbild. 7. Himmelsphysik: Die Debatte um die causa gravitatis. 8. Theorie der Himmelskörper. 9. Die Erde als Gegenstand der Astronomie. 10. Die Sonne. 11. Der Mond. 12. Die Planeten. 13. Die Kometen. 14. Die Fixsterne. 15. Die Entstehung der Welt. 16. Beiträge der Astrotheologie. 17. Der Kampf gegen die Astrologen.

  4. An exploratory analysis of the factor structure of the Dysfunctional Attitude Scale-Form A (DAS).

    PubMed

    Moore, Michael T; Fresco, David M; Segal, Zindel V; Brown, Timothy A

    2014-10-01

    A number of studies have attempted to identify the factor structure of the Dysfunctional Attitude Scale (DAS). However, no studies have done so using a clinical sample of outpatients likely to generalize to the clinical trials in which the DAS is commonly used. The current investigation utilized exploratory structural equation modeling in an outpatient sample (N = 982) and found support for a one-factor solution (composed of 19 items). This solution was largely confirmed in a second outpatient sample (N = 301). Construct validity was demonstrated in correlations with measures of depression, social interaction anxiety, and symptoms of obsessive-compulsive disorder. © The Author(s) 2014.

  5. Das Prinzip Bewegung - Herz und Gehirn als Metaphern des menschlichen Lebens

    NASA Astrophysics Data System (ADS)

    Otis, Laura

    In diesem Jahr, in dem wir Charles Darwins gedenken, möchte ich etwas riskieren und eine Frage erörtern, die für die Literatur ebenso wie für die Biologie zentral ist: Was ist das Leben? Die Antwort auf diese Frage finden wir nicht in der Bibliothek und nicht im Labor, zumindest nicht an diesen erkenntnisproduzierenden Stellen allein. Als Literaturwissenschaftlerin und ehemalige Naturwissenschaftlerin glaube ich, dass wir das Leben nur verstehen werden, wenn wir seinen Wirkungen überall nachforschen, inklusive in der Literatur.

  6. The Deaf Acculturation Scale (DAS): development and validation of a 58-item measure.

    PubMed

    Maxwell-McCaw, Deborah; Zea, Maria Cecilia

    2011-01-01

    This study involved the development and validation of the Deaf Acculturation Scale (DAS), a new measure of cultural identity for Deaf and hard-of-hearing (hh) populations. Data for this study were collected online and involved a nation-wide sample of 3,070 deaf/hh individuals. Results indicated strong internal reliabilities for all the subscales, and construct validity was established by demonstrating that the DAS could discriminate groups based on parental hearing status, school background, and use of self-labels. Construct validity was further demonstrated through factorial analyses, and findings resulted in a final 58-item measure. Directions for future research are discussed.

  7. Anbindung des SISIS-SunRise-Bibliothekssystems an das zentrale Identitätsmanagement

    NASA Astrophysics Data System (ADS)

    Ebner, Ralf; Pretz, Edwin

    Wir berichten über Konzepte und Implementierungen zur Datenprovisionierung aus den Personenverwaltungssystemen der Technischen Universität München (TUM) über das zentrale Metadirectory am Leibniz-Rechenzentrum (LRZ) in das SISIS-SunRise-Bibliothekssystem der Universitätsbibliothek der TUM (TUB). Es werden drei Implementierungsvarianten diskutiert, angefangen von der Generierung und Übertragung einfacher CSV-Dateien über ein OpenLDAP-basiertes Konzept als Backend für die SISIS-Datenbank bis zur endgültigen Implementierung mit dem OCLC IDM Connector.

  8. Landsat 8's atmospheric correction in SeaDAS: comparison with AERONET-OC (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Concha, Javier A.

    2016-09-01

    There is a growing interest in high spatial resolution imagery for the retrieval of biogeochemical components over water to study the processes involved in inland and coastal waters as well as in the open ocean. High spatial resolution satellite presents a kind of different problems to the ones for coarse spatial resolution satellites (i.e. MODIS) for deriving ocean color products (i.e. chlorophyll-a or colored dissolved organic matter at a specific wavelength). The SeaDAS package has recently added the capability to handle Landsat 8 data and to produce ocean color standard products, but validation of the atmospheric correction with in situ data is needed. In this work, different schemes for atmospheric correction within SeaDAS are applied. These schemes include the use of the NIR-SWIR 2, SWIR 1-SWIR 2 combinations, with and without spatial averaging to account for the low signal-to-noise ratio (SNR) in the SWIR bands. The products from the atmospheric correction in SeaDAS, i.e. remote-sensing reflectance (Rrs) at four different wavelengths, are compared with in situ data. This is the first attempt to compare in situ Rrs with the output from SeaDAS/l2gen.

  9. PoroTomo Project - Subatask 6.2: Deploy and Operate DAS and DTS arrays

    SciTech Connect

    Dante Fratta

    2016-03-31

    This metadata submission includes the coordinates of the DAS and DTS surface and borehole arrays, the list of file names, and the list of recorded files during testing at the PoroTomo Natural Laboratory at Brady Hot Spring in Nevada. Testing was completed during March 2016.

  10. The Deaf Acculturation Scale (DAS): Development and Validation of a 58-Item Measure

    ERIC Educational Resources Information Center

    Maxwell-McCaw, Deborah; Zea, Maria Cecilia

    2011-01-01

    This study involved the development and validation of the Deaf Acculturation Scale (DAS), a new measure of cultural identity for Deaf and hard-of-hearing (hh) populations. Data for this study were collected online and involved a nation-wide sample of 3,070 deaf/hh individuals. Results indicated strong internal reliabilities for all the subscales,…

  11. I/O Parallelization for the Goddard Earth Observing System Data Assimilation System (GEOS DAS)

    NASA Technical Reports Server (NTRS)

    Lucchesi, Rob; Sawyer, W.; Takacs, L. L.; Lyster, P.; Zero, J.

    1998-01-01

    The National Aeronautics and Space Administration (NASA) Data Assimilation Office (DAO) at the Goddard Space Flight Center (GSFC) has developed the GEOS DAS, a data assimilation system that provides production support for NASA missions and will support NASA's Earth Observing System (EOS) in the coming years. The GEOS DAS will be used to provide background fields of meteorological quantities to EOS satellite instrument teams for use in their data algorithms as well as providing assimilated data sets for climate studies on decadal time scales. The DAO has been involved in prototyping parallel implementations of the GEOS DAS for a number of years and is now embarking on an effort to convert the production version from shared-memory parallelism to distributed-memory parallelism using the portable Message-Passing Interface (MPI). The GEOS DAS consists of two main components, an atmospheric General Circulation Model (GCM) and a Physical-space Statistical Analysis System (PSAS). The GCM operates on data that are stored on a regular grid while PSAS works with observational data that are scattered irregularly throughout the atmosphere. As a result, the two components have different data decompositions. The GCM is decomposed horizontally as a checkerboard with all vertical levels of each box existing on the same processing element(PE). The dynamical core of the GCM can also operate on a rotated grid, which requires communication-intensive grid transformations during GCM integration. PSAS groups observations on PEs in a more irregular and dynamic fashion.

  12. The Great War and Remembrance in Jose Leon Machado's "Memoria das Estrelas sem Brilho"

    ERIC Educational Resources Information Center

    Azevedo, Milton M.

    2011-01-01

    This article analyzes Jose Leon Machado's novel, "Memoria das Estrelas sem Brilho," as a multilayered historical novel in which a war story provides a background for comments on aspects of early twentieth-century Portuguese society, such as male bonding, religion, sexual mores, and social stratification. (Contains 11 notes.)

  13. Psychometric properties of the Disability Assessment Schedule (DAS) for behavior problems: an independent investigation.

    PubMed

    Tsakanikos, Elias; Underwood, Lisa; Sturmey, Peter; Bouras, Nick; McCarthy, Jane

    2011-01-01

    The present study employed the Disability Assessment Schedule (DAS) to assess problem behaviors in a large sample of adults with ID (N=568) and evaluate the psychometric properties of this instrument. Although the DAS problem behaviors were found to be internally consistent (Cronbach's α=.87), item analysis revealed one weak item ('Objectional habits') with item-total biserial correlation of only .20. An exploratory factor analysis revealed two main factors. The first factor consisted of items relating to disruptive/distractive problems. The second factor consisted of items relating to antisocial/delinquent problems. Disruptive/distractive problems were specifically associated with low ID level. Antisocial/delinquent behaviors were specifically associated with male gender, schizophrenia, hospital admission and troubles with police. For patients who had both disruptive/distractive problems and antisocial/delinquent behaviors, personality disorders and autism were more frequent, where as anxiety and depression were less frequent. On the basis of the obtained results, two new DAS subscales for assessing challenging behavior were proposed. Both subscales had good levels of internal consistency, as well as face and criterion validity. Overall, the new DAS subscales were shown to have acceptable psychometric properties and have therefore potential for use in both research and clinical practice. Copyright © 2010 Elsevier Ltd. All rights reserved.

  14. The Great War and Remembrance in Jose Leon Machado's "Memoria das Estrelas sem Brilho"

    ERIC Educational Resources Information Center

    Azevedo, Milton M.

    2011-01-01

    This article analyzes Jose Leon Machado's novel, "Memoria das Estrelas sem Brilho," as a multilayered historical novel in which a war story provides a background for comments on aspects of early twentieth-century Portuguese society, such as male bonding, religion, sexual mores, and social stratification. (Contains 11 notes.)

  15. The Deaf Acculturation Scale (DAS): Development and Validation of a 58-Item Measure

    ERIC Educational Resources Information Center

    Maxwell-McCaw, Deborah; Zea, Maria Cecilia

    2011-01-01

    This study involved the development and validation of the Deaf Acculturation Scale (DAS), a new measure of cultural identity for Deaf and hard-of-hearing (hh) populations. Data for this study were collected online and involved a nation-wide sample of 3,070 deaf/hh individuals. Results indicated strong internal reliabilities for all the subscales,…

  16. MiDAS: the field guide to the microbes of activated sludge

    PubMed Central

    McIlroy, Simon Jon; Saunders, Aaron Marc; Albertsen, Mads; Nierychlo, Marta; McIlroy, Bianca; Hansen, Aviaja Anna; Karst, Søren Michael; Nielsen, Jeppe Lund; Nielsen, Per Halkjær

    2015-01-01

    The Microbial Database for Activated Sludge (MiDAS) field guide is a freely available online resource linking the identity of abundant and process critical microorganisms in activated sludge wastewater treatment systems to available data related to their functional importance. Phenotypic properties of some of these genera are described, but most are known only from sequence data. The MiDAS taxonomy is a manual curation of the SILVA taxonomy that proposes a name for all genus-level taxa observed to be abundant by large-scale 16 S rRNA gene amplicon sequencing of full-scale activated sludge communities. The taxonomy can be used to classify unknown sequences, and the online MiDAS field guide links the identity to the available information about their morphology, diversity, physiology and distribution. The use of a common taxonomy across the field will provide a solid foundation for the study of microbial ecology of the activated sludge process and related treatment processes. The online MiDAS field guide is a collaborative workspace intended to facilitate a better understanding of the ecology of activated sludge and related treatment processes—knowledge that will be an invaluable resource for the optimal design and operation of these systems. Database URL: http://www.midasfieldguide.org PMID:26120139

  17. Incorporating Parallel Computing into the Goddard Earth Observing System Data Assimilation System (GEOS DAS)

    NASA Technical Reports Server (NTRS)

    Larson, Jay W.

    1998-01-01

    Atmospheric data assimilation is a method of combining actual observations with model forecasts to produce a more accurate description of the earth system than the observations or forecast alone can provide. The output of data assimilation, sometimes called the analysis, are regular, gridded datasets of observed and unobserved variables. Analysis plays a key role in numerical weather prediction and is becoming increasingly important for climate research. These applications, and the need for timely validation of scientific enhancements to the data assimilation system pose computational demands that are best met by distributed parallel software. The mission of the NASA Data Assimilation Office (DAO) is to provide datasets for climate research and to support NASA satellite and aircraft missions. The system used to create these datasets is the Goddard Earth Observing System Data Assimilation System (GEOS DAS). The core components of the the GEOS DAS are: the GEOS General Circulation Model (GCM), the Physical-space Statistical Analysis System (PSAS), the Observer, the on-line Quality Control (QC) system, the Coupler (which feeds analysis increments back to the GCM), and an I/O package for processing the large amounts of data the system produces (which will be described in another presentation in this session). The discussion will center on the following issues: the computational complexity for the whole GEOS DAS, assessment of the performance of the individual elements of GEOS DAS, and parallelization strategy for some of the components of the system.

  18. A Brief History of the J.P. Das Developmental Disabilities Centre

    ERIC Educational Resources Information Center

    Sobsey, Dick

    2008-01-01

    The J.P. Das Developmental Disabilities Centre celebrated its 40th anniversary on September 1, 2007, followed by The University of Alberta's 100th anniversary in 2008. The year 2008 also brought the appointment of a new Director for the Centre. As the immediate past Director of the Centre, the author recounts some of the history of the J.P. Das…

  19. Abpfiff für das Fußball-Universum

    NASA Astrophysics Data System (ADS)

    Bartelmann, Matthias

    2005-03-01

    Aus Beobachtungen der kosmischen Hintergrundstrahlung lassen sich zwar Rückschlüsse auf die Größe und die Topologie des Universums ziehen. Die Behauptung, aus den Daten des Satelliten WMap würde folgen, dass das Universum endlich groß sei und die Topologie eines Dodekaeders aufweise, wurde jedoch widerlegt.

  20. MiDAS: the field guide to the microbes of activated sludge.

    PubMed

    McIlroy, Simon Jon; Saunders, Aaron Marc; Albertsen, Mads; Nierychlo, Marta; McIlroy, Bianca; Hansen, Aviaja Anna; Karst, Søren Michael; Nielsen, Jeppe Lund; Nielsen, Per Halkjær

    2015-01-01

    The Microbial Database for Activated Sludge (MiDAS) field guide is a freely available online resource linking the identity of abundant and process critical microorganisms in activated sludge wastewater treatment systems to available data related to their functional importance. Phenotypic properties of some of these genera are described, but most are known only from sequence data. The MiDAS taxonomy is a manual curation of the SILVA taxonomy that proposes a name for all genus-level taxa observed to be abundant by large-scale 16 S rRNA gene amplicon sequencing of full-scale activated sludge communities. The taxonomy can be used to classify unknown sequences, and the online MiDAS field guide links the identity to the available information about their morphology, diversity, physiology and distribution. The use of a common taxonomy across the field will provide a solid foundation for the study of microbial ecology of the activated sludge process and related treatment processes. The online MiDAS field guide is a collaborative workspace intended to facilitate a better understanding of the ecology of activated sludge and related treatment processes--knowledge that will be an invaluable resource for the optimal design and operation of these systems. © The Author(s) 2015. Published by Oxford University Press.

  1. Reisen im freien Fall - Teil 2: Das Zwillingsparadoxon aus dem Blickwinkel der ART

    NASA Astrophysics Data System (ADS)

    Sonne, Bernd; Weiß, Reinhard

    2013-07-01

    Nachdem wir uns mit den Prinzipien der ART und einigen Beispielen vertraut gemacht haben, kommen wir nun zur Berechnung des Zwillingsparadoxons aus Sicht des reisenden Zwillings. Dabei spielt das Äquivalenzprinzip eine große Rolle. Deshalb wird die Bewegungssituation noch einmal erläutert, diesmal aus Sicht von Katrin. Sie befindet sich in ihrem System S'in Ruhe. In ihrem System läuft die Zeit t'ab. Nach dem Start fühlt Katrin jedoch eine Kraft, die sie als Gravitationskraft interpretieren kann. Sie merkt es daran, dass sie in den Sitz gedrückt wird. Nach einiger Zeit werden die Triebwerke abgeschaltet, und das Raumschiff fliegt mit konstanter Geschwindigkeit weiter, Phase 2. Anschließend wird der Schub der Triebwerke solange umgekehrt, bis das Raumschiff irgendwo mit der Geschwindigkeit null am Umkehrpunkt U landet, Phase 3 (Abb. 15.1). Die Erde, auf der sich Michael befindet, bewegt sich mit x'(t') aus Sicht von Katrin im freien Fall von ihr weg, s. das Experiment mit dem steigenden Fahrstuhl in Abschn. 13.2.1.

  2. Performance of broiler chickens fed diets containing DAS-68416-4 soybean meal.

    PubMed

    Herman, Rod A; Dunville, Christina M; Juberg, Daland R; Fletcher, Dale W; Cromwell, Gary L

    2011-01-01

    Broiler chickens are a fast growing monogastric animal commonly used to evaluate the equivalence between transgenic and non-transgenic grains as part of the human safety assessment process. While commonly viewed like other livestock feeding trials, such studies are performed with transgenic crops with input traits (that are not designed to improve nutrition) to aid regulatory authorities in evaluating safety. Studies of this type are actually more similar to toxicology studies in purpose, with sensitive endpoints like growth used to detect metabolic perturbations. DAS-68416-4 soybean expresses the aryloxyalkanoate dioxygenase-12 (AAD-12) enzyme which inactivates 2,4-diclorophenoxyacetic acid (2,4-D) and provides DAS-68416-4 soybeans tolerance to this herbicide. DAS-68416-4 also expresses the phosphinothricin acetyltransferase (PAT) enzyme from Streptomyces viridochromogenes which confers tolerance to glufosinate-ammonium herbicides. A 6-week broiler study was conducted with diets containing toasted DAS-68416-4 soybean meal (40, 36, and 32% in starter, grower and finisher diets, respectively) to evaluate nutritional wholesomeness and safety compared with conventional comparators. Toasting soybean meal is required to inactivate endogenous antinutrients making soybean suitable for consumption by monogastric animals like broiler chickens. Toasting was found to denature both the AAD-12 and PAT proteins rendering them non-detectable by enzyme linked immunosorbent assays. Broiler growth and performance parameters were measured over a 6-week period of exposure to diets containing different sources of toasted soybean meal, and results indicate that DAS-68416-4 soybean is nutritionally equivalent to non-transgenic soybean.

  3. Detecting changes following the provision of assistive devices: utility of the WHO-DAS II.

    PubMed

    Raggi, Alberto; Albanesi, Francesca; Gatti, Valeria; Andrich, Renzo; Leonardi, Matilde

    2010-12-01

    The World Health Organization Disability Assessment Schedule II (WHO-DAS II) is a non-disease-specific International Classification of Functioning, Disability, and Health-based disability assessment instrument developed to measure activity limitations and restrictions to participation. The aim of this pilot study is to evaluate WHO-DAS II responsiveness in detecting short-time changes following the provision of an Assistive Technology,which is important to define its utility in performing daily activities. Adult inpatients with a diagnosis of Disease of the Nervous System (included in Chapter VI of the ICD-10),who were prescribed an Assistive Technology to be used in the household settings, were enrolled. The WHO-DAS II was administered in individual interview at baseline and at a 2 months follow-up: in this period patients were transitioning from the hospital to home. Changes in disability profiles were detected by calculating the effect size (ES) for each WHO-DAS II domain. Ten patients with different neurological diseases were enrolled. Few longitudinal changes in disability level are reported: mild improvement is observed in the household activities (ES0.28), whereas mild worsening is reported in self-care and participation in society domains (ES – 0.27 and – 0.26,respectively). Our study shows that the WHO-DAS II is responsive in detecting domain-specific changes over a short-term period and provides preliminary encouraging evidence for the utility of its utilization in clinical settings.However, changes in setting between baseline and follow up could have an impact on the findings and interpretation of this study.

  4. A 90 day chronic toxicity study of Nigerian herbal preparation DAS-77 in rats

    PubMed Central

    2012-01-01

    Background The herbal preparation DAS-77, used for the treatment of various ailments in Nigeria, contains the milled bark of Mangifera indica L. and root of Carica papaya L. Toxicological assessment of the preparation was carried out in this study. Methods In the acute toxicity study, DAS-77 was administered to mice p.o. up to 20 g/kg in divided doses and i.p. at 250–3000 mg/kg. Mortality within 24 h was recorded. In the chronic toxicity study, rats were treated p.o. for 90 days at doses of 80, 400 (therapeutic dose, TD) and 2000 mg/kg. By 90 days, animals were sacrificed and blood samples collected for hematological and biochemical analysis. Organs were harvested for weight determination, antioxidants and histopathological assessments. Results DAS-77 did not produce any lethality administered p.o. up to 20 g/kg in divided doses but the i.p. LD50 was 1122.0 mg/kg. At TD, DAS-77 produced significant (p < 0.05) reductions in body weight, food intake and K+, and increases in ovary weight, neutrophils and HDL, which were reversible. Histopathological presentations were generally normal. Effects at the other doses were comparable to those at TD except for reversible increases in antioxidants in the liver, kidney and testes, and sperm abnormality, and reductions in liver enzymes, sperm motility and count. Conclusions Findings in this study revealed that DAS-77 is relatively safe with the potential for enhancing in vivo antioxidant activity. However, possibly reversible side-effects include electrolyte imbalance and sterility in males. PMID:22892317

  5. DAS steered therapy in clinical practice; cross-sectional results from the METEOR database.

    PubMed

    Gvozdenović, Emilia; Wolterbeek, Ron; van der Heijde, Désirée; Huizinga, Tom; Allaart, Cornelia; Landewé, Robert

    2016-01-16

    Little is known on how well targeted treatment, for instance targeting towards low DAS, is implemented in clinical practice. Our aim was to evaluate treatment adjustments in response to DAS in RA patients in clinical practice. We used data from one referral centre, multiple rheumatologists, from the METEOR database. Generalized Estimating Equations (GEE) were used to assess whether in case of non-low disease activity (DAS > 2.4) treatment intensifications in DMARD therapy occurred ((change or increase in dose or number of DMARDs, including synthetic (s)DMARDs, biologic (b)DMARDs and corticosteroids compared to the visit before)). Determinants of not intensifying the treatment when DAS > 2.4 were investigated using GEE. Five thousand one hundred fifty-seven registered visits of 1202 patients were available for the analyses. A DAS > 2.4 was weakly (OR: 1.19; 95% CI 1.07-1.33) associated with a treatment intensification. In 69% (n = 3577) of the visits patients were in low disease activity. In 66% (n = 1028) of the visits with DAS > 2.4 treatment was not intensified. These patients had a higher tender joint count and received more often methotrexate plus a bDMARD, or csDMARD monotherapy, as compared to patients that received treatment intensification. In the majority of visits in the METEOR database patients were already in a state of low disease activity, reflecting appropriate treatment intensity. When DAS was greater than 2.4, treatment was often not intensified due to high tender joint count or specific treatment combinations. This data suggest that while aiming for low DAS, physicians per patient weigh whether all DAS elements indicate disease activity or will respond to DMARD adjustment or not, and make treatment decisions accordingly.

  6. 50 CFR 648.53 - Acceptable biological catch (ABC), annual catch limits (ACL), annual catch targets (ACT), DAS...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... catch limits (ACL), annual catch targets (ACT), DAS allocations, and individual fishing quotas (IFQ... limits (ACL), annual catch targets (ACT), DAS allocations, and individual fishing quotas (IFQ). (a... limited access scallop fishery shall be allocated 94.5 percent of the ACL specified in paragraph (a)(1)...

  7. A Letter to the Parent(s) of a Child with Developmental Apraxia of Speech. Part IV: Treatment of DAS.

    ERIC Educational Resources Information Center

    Hall, Penelope K.

    2000-01-01

    One of a series of letters to parents of children with developmental apraxia of speech (DAS), this letter discusses the treatment of DAS including linguistic approaches, motor-programming approaches, a combination of linguistic and motor-programming approaches, and treatment approaches that include specific sensory and gestural cueing techniques.…

  8. A Letter to the Parent(s) of a Child with Developmental Apraxia of Speech. Part IV: Treatment of DAS.

    ERIC Educational Resources Information Center

    Hall, Penelope K.

    2000-01-01

    One of a series of letters to parents of children with developmental apraxia of speech (DAS), this letter discusses the treatment of DAS including linguistic approaches, motor-programming approaches, a combination of linguistic and motor-programming approaches, and treatment approaches that include specific sensory and gestural cueing techniques.…

  9. dnaA suppressor (dasF) mutants of Escherichia coli are stable DNA replication (sdrA/rnh) mutants.

    PubMed

    Torrey, T A; Atlung, T; Kogoma, T

    1984-01-01

    The possible allelic relationship between dasF (dnaA suppressor) and sdrA/rnh (stable DNA replication/RNase H) mutations was examined. dasF mutations could not only suppress various dnaA(ts) mutations, but also the insertional inactivation of the dnaA gene or deletion of the oriC sequence, as could sdrA mutations. dasF mutants were found to exhibit the stable DNA replication phenotype, and the sensitivity to rich media, of sdrA mutants. The dasF and sdrA mutations were mapped very closely between metD and proA on the E. coli genetic map. The mutations were recessive to the wild-type allele for all the above phenotypes. It was concluded that dasF is allelic to sdrA/mh.

  10. Annotation and visualization of endogenous retroviral sequences using the Distributed Annotation System (DAS) and eBioX

    PubMed Central

    Martínez Barrio, Álvaro; Lagercrantz, Erik; Sperber, Göran O; Blomberg, Jonas; Bongcam-Rudloff, Erik

    2009-01-01

    Background The Distributed Annotation System (DAS) is a widely used network protocol for sharing biological information. The distributed aspects of the protocol enable the use of various reference and annotation servers for connecting biological sequence data to pertinent annotations in order to depict an integrated view of the data for the final user. Results An annotation server has been devised to provide information about the endogenous retroviruses detected and annotated by a specialized in silico tool called RetroTector. We describe the procedure to implement the DAS 1.5 protocol commands necessary for constructing the DAS annotation server. We use our server to exemplify those steps. Data distribution is kept separated from visualization which is carried out by eBioX, an easy to use open source program incorporating multiple bioinformatics utilities. Some well characterized endogenous retroviruses are shown in two different DAS clients. A rapid analysis of areas free from retroviral insertions could be facilitated by our annotations. Conclusion The DAS protocol has shown to be advantageous in the distribution of endogenous retrovirus data. The distributed nature of the protocol is also found to aid in combining annotation and visualization along a genome in order to enhance the understanding of ERV contribution to its evolution. Reference and annotation servers are conjointly used by eBioX to provide visualization of ERV annotations as well as other data sources. Our DAS data source can be found in the central public DAS service repository, , or at . PMID:19534743

  11. Clinical potential of DAS181 for treatment of parainfluenza-3 infections in transplant recipients.

    PubMed

    Guzmán-Suarez, B B; Buckley, M W; Gilmore, E T; Vocca, E; Moss, R; Marty, F M; Sanders, R; Baden, L R; Wurtman, D; Issa, N C; Fang, F; Koo, S

    2012-08-01

    Parainfluenza virus (PIV) infections can cause serious respiratory infections and death in immunocompromised patients. No antiviral agents have proven efficacy against PIV, and therapy generally consists of supportive care. DAS181, a novel sialidase fusion protein that temporarily disables airway epithelial PIV receptors by enzymatic removal of sialic acid moieties, has been shown to inhibit infection with PIV strains in vitro and in an animal model. We describe here the clinical course of 2 immunocompromised patients with PIV-3 infection, one with a history of lung transplantation and the other neutropenic after autologous hematopoietic stem cell transplantation for multiple myeloma. Both patients had substantial clinical improvement in respiratory and systemic symptoms after a 5-day DAS181 treatment course, although the clinical improvement in the autologous stem cell transplantation patient also paralleled neutrophil engraftment.

  12. Smart Home, Smart Grid, Smart Meter - digitale Konzepte und das Recht an Daten

    NASA Astrophysics Data System (ADS)

    Spiecker genannt Döhmann, Indra

    Modernes Energiemanagement setzt auf ein intelligent gesteuertes Energieinformationsnetz, das Smart Grid. In diesem ist der Smart Meter, die intelligente Messstelle beim Nutzer, ein zentrales Instrument für den wechselseitigen Austausch von Informationen. Allerdings werfen die über diverse Gesetze forcierten Informationsströme erhebliche datenschutzrechtliche Fragen auf. Der Beitrag stellt zentrale datenschutzrechtliche Leitlinien und Probleme vor und behandelt auch offene Fragestellungen.

  13. DAS Boot!

    ERIC Educational Resources Information Center

    Chretien, Wendy

    2007-01-01

    The residential services group is lobbying to dump its aging hard-wired phone system because students don't use it. The town and campus public safety officials are demanding that their portable two-way radios operate well not only outdoors, but within campus buildings. Students are now expecting text messaging and WiFi service to work everywhere…

  14. DAS Boot!

    ERIC Educational Resources Information Center

    Chretien, Wendy

    2007-01-01

    The residential services group is lobbying to dump its aging hard-wired phone system because students don't use it. The town and campus public safety officials are demanding that their portable two-way radios operate well not only outdoors, but within campus buildings. Students are now expecting text messaging and WiFi service to work everywhere…

  15. Inhibition of cyclooxygenase-2 by diallyl sulfides (DAS) in HEK 293T cells.

    PubMed

    Elango, Erode M; Asita, Hag; Nidhi, Gunapalan; Seema, Parvathy; Banerji, Asoke; Kuriakose, Moni A

    2004-01-01

    Cyclooxygenase (COX) is involved in modulating inflammatory response through the synthesis of prostaglandins. The inducible isoform of the enzyme, COX-2, is overexpressed in some malignant and premalignant lesions. Several preclinical and clinical studies have reported COX-2 inhibition as an effective strategy for chemoprevention. Nonsteroidal anitinflammatory drugs (NASIDs) such as celecoxib, are the most widely investigated COX-2 inhibitors. The oil-soluble diallyl sulfides (DAS) include monosulfides (DAMS), disulfides (DADS) and trisulfides (DATS). They were found to be effective against canine and human tumors, the mechanism of which remains unresolved. We attempted a comparative evaluation of the antiproliferative effect of DAS in HEK 293T cells. The cells were treated with increasing concentrations of DAMS, DADS and DATS. There were significant differences between the IC50 values of DAMS, DADS and DATS. RT-PCR was performed and the expression of COX-2 was compared with that of b actin. DATS inhibited COX-2 gene expression significantly stronger than DAMS and DADS. The data are suggestive of antineoplastic effect of DAS, mediated by controlling COX-2 expression.

  16. pH modulates arsenic toxicity in Bacillus licheniformis DAS-2.

    PubMed

    Tripti, K; Shardendu

    2016-08-01

    The toxic characteristics of arsenic species, As(V) and As(III) result in ecological risks. Arsenic tolerant bacterium was isolated and identified as the Bacillus licheniformis DAS-2 through 16SrDNA sequencing. B. licheniformis DAS-2 was efficient to tolerate and remove both the As(V)[MIC 8mM] and As(III)[MIC 6mM] from the growth medium. The potential for the removal/uptake of arsenic from the 3, 5 and 7mM As(V) enriched growth media was 100%, 60% and 35% respectively and from the 1, 3 and 5mM As(III) enrichment it was 100%, 99% and 58% respectively at neutral pH. 80% of uptake As(V) was reduced to As(III) in 3mM As(V) enrichment which was gradually decreased to only 17% at 7mM As(V) enrichment at neutral pH. The arsenic toxicity in B. licheniformis DAS-2 was found modulated by pH and was examined through alteration in growth, uptake/removal, reduction and measurement of chemical toxicity.

  17. Assimilation of SBUV Version 8 Radiances into the GEOS Ozone DAS

    NASA Technical Reports Server (NTRS)

    Mueller, Martin D.; Stajner, Ivanka; Bhartia, Pawan K.

    2004-01-01

    In operational weather forecasting, the assimilation of brightness temperatures from satellite sounders, instead of assimilation of 1D-retrievals has become increasingly common practice over the last two decades. Compared to these systems, assimilation of trace gases is still at a relatively early stage of development, and efforts to directly assimilate radiances instead of retrieved products have just begun a few years ago, partially because it requires much more computation power due to the employment of a radiative transport forward model (FM). This paper will focus on a method to assimilate SBUV/2 radiances (albedos) into the Global Earth Observation System Ozone Data Assimilation Scheme (GEOS-03DAS). While SBUV-type instruments cannot compete with newer sensors in terms of spectral and horizontal resolution, they feature a continuous data record back to 1978, which makes them very valuable for trend studies. Assimilation can help spreading their ground coverage over the whole globe, as has been previously demonstrated with the GEOS-03DAS using SBUV Version 6 ozone profiles. Now, the DAS has been updated to use the newly released SBUV Version 8 data. We will compare pre]lmlnarv results of SBUV radiance assimilation with the assimilation of retrieved ozone profiles, discuss methods to deal with the increased computational load, and try to assess the error characteristics and future potential of the new approach.

  18. Performance of broiler chickens fed event DAS-40278-9 maize containing the aryloxyalkanoate dioxygenase-1 protein.

    PubMed

    Herman, Rod A; Dunville, Christina M; Juberg, Daland R; Fletcher, Dale W; Cromwell, Gary L

    2011-08-01

    Event DAS-40278-9 maize grain (containing the aryloxyalkanoate dioxygenase-1 protein), a non-transgenic near-isogenic maize grain, or one of three commercial maize grains were included in the diets of broiler chickens for six weeks. Growth, feed conversion, and carcass measurements indicated no significant difference between the groups fed the diets containing the DAS-40278-9 maize grain and those fed diets containing the matched control grain. The absence of adverse effects in this study supports the dietary safety of the AAD-1 protein expressed in event DAS-40278-9 maize. Copyright © 2011 Elsevier Inc. All rights reserved.

  19. I/O Parallelization for the Goddard Earth Observing System Data Assimilation System (GEOS DAS)

    NASA Technical Reports Server (NTRS)

    Lucchesi, R.; Sawyer, W.; Takacs, L. L.; Lyster, P.; Zero, J.

    1999-01-01

    The National Aeronautics and Space Administration (NASA) Data Assimilation Office (DAO) at the Goddard Space Flight Center (GSFC) has developed the GEOS DAS, a data assimilation system that provides production support for NASA missions and will support NASA's Earth Observing System (EOS) in the coming years. The DAO's support of the EOS project along with the requirement of producing long-term reanalysis datasets with an unvarying system levy a large I/O burden on the future system. The DAO has been involved in prototyping parallel implementations of the GEOS DAS for a number of years and is now converting the production version from shared-memory parallelism to distributed-memory parallelism using the portable Message-Passing Interface (MPI). If the MPI-based GEOS DAS is to meet these production requirements, we must make I/O from the parallel system efficient. We have designed a scheme that allows efficient I/O processing while retaining portability, reducing the need for post-processing, and producing data formats that are required by our users, both internal and external. The first phase of the GEOS DAS Parallel I/O System (GPIOS) will expand upon the common method of gathering global data to a Single PE for output. Instead of using a PE also tasked with primary computation, a number of PEs will be dedicated to I/O and its related tasks. This allows the data transformations and formatting required prior to output to take place asynchronously with respect to the GEOS DAS assimilation cycle, improving performance and generating output data sets in a format convenient for our users. I/O PEs can be added as needed to handle larger data volumes or to meet user file specifications. We will show I/O performance results from a prototype MPI GCM integrated with GPIOS. Phase two of GPIOS development will examine ways of integrating new software technologies to further improve performance and build scalability into the system. The maturing of MPI-IO implementations and

  20. I/O Parallelization for the Goddard Earth Observing System Data Assimilation System (GEOS DAS)

    NASA Technical Reports Server (NTRS)

    Lucchesi, R.; Sawyer, W.; Takacs, L. L.; Lyster, P.; Zero, J.

    1999-01-01

    The National Aeronautics and Space Administration (NASA) Data Assimilation Office (DAO) at the Goddard Space Flight Center (GSFC) has developed the GEOS DAS, a data assimilation system that provides production support for NASA missions and will support NASA's Earth Observing System (EOS) in the coming years. The DAO's support of the EOS project along with the requirement of producing long-term reanalysis datasets with an unvarying system levy a large I/O burden on the future system. The DAO has been involved in prototyping parallel implementations of the GEOS DAS for a number of years and is now converting the production version from shared-memory parallelism to distributed-memory parallelism using the portable Message-Passing Interface (MPI). If the MPI-based GEOS DAS is to meet these production requirements, we must make I/O from the parallel system efficient. We have designed a scheme that allows efficient I/O processing while retaining portability, reducing the need for post-processing, and producing data formats that are required by our users, both internal and external. The first phase of the GEOS DAS Parallel I/O System (GPIOS) will expand upon the common method of gathering global data to a Single PE for output. Instead of using a PE also tasked with primary computation, a number of PEs will be dedicated to I/O and its related tasks. This allows the data transformations and formatting required prior to output to take place asynchronously with respect to the GEOS DAS assimilation cycle, improving performance and generating output data sets in a format convenient for our users. I/O PEs can be added as needed to handle larger data volumes or to meet user file specifications. We will show I/O performance results from a prototype MPI GCM integrated with GPIOS. Phase two of GPIOS development will examine ways of integrating new software technologies to further improve performance and build scalability into the system. The maturing of MPI-IO implementations and

  1. How to assess appearance distress and motivation in plastic surgery candidates: Italian validation of Derriford Appearance Scale 59 (DAS 59).

    PubMed

    Cogliandro, A; Persichetti, P; Ghilardi, G; Moss, T P; Barone, M; Piccinocchi, G; Ricci, G; Vitali, M; Giuliani, A; Tambone, V

    2016-09-01

    The Derriford Appearance Scale (DAS) 59 was specifically designed to measure psychosocial adjustment in patients with appearance problems. Previous studies using the DAS59 have proven it to be a reliable method of assessing the appearance-related quality of life after plastic surgery procedures. The aim of this study was to develop a valid and reliable Italian version of the DAS59. The first Italian translation of this questionnaire was conducted according to the DAS59 protocol that was designed by the original authors of the questionnaire. Eight hundred patients participated in this study and filled out three questionnaires (DAS59, General Health Questionnaire (GHQ)12 and Beck's Depression Inventory (BDI)-II). There were 400 adult patients with a history of previous plastic surgeries and 400 adult patients without any personal history of previous plastic surgery procedures. A total of 50 patients were selected randomly for test-retest analysis. The overall internal consistency was excellent (α = 0.95) and equal to that of the original article that first described the scale. There was a good correlation between all the items. Domains demonstrated good internal consistency (Cronbach's alpha) and correlation within themselves. The construct validity of the Italian DAS59 was assessed under convergent validity that confirmed the correlation with scales related to other psychological conditions. GHQ12 showed relevant correlation with DAS59, while BDI-II did not. A valid and reliable Italian DAS59 version was developed that can be used for research and clinical assessment of patients with appearance problems and concerns, especially before and after plastic surgery procedures.

  2. Annotation and visualization of endogenous retroviral sequences using the Distributed Annotation System (DAS) and eBioX.

    PubMed

    Barrio, Alvaro Martínez; Lagercrantz, Erik; Sperber, Göran O; Blomberg, Jonas; Bongcam-Rudloff, Erik

    2009-06-16

    The Distributed Annotation System (DAS) is a widely used network protocol for sharing biological information. The distributed aspects of the protocol enable the use of various reference and annotation servers for connecting biological sequence data to pertinent annotations in order to depict an integrated view of the data for the final user. An annotation server has been devised to provide information about the endogenous retroviruses detected and annotated by a specialized in silico tool called RetroTector. We describe the procedure to implement the DAS 1.5 protocol commands necessary for constructing the DAS annotation server. We use our server to exemplify those steps. Data distribution is kept separated from visualization which is carried out by eBioX, an easy to use open source program incorporating multiple bioinformatics utilities. Some well characterized endogenous retroviruses are shown in two different DAS clients. A rapid analysis of areas free from retroviral insertions could be facilitated by our annotations. The DAS protocol has shown to be advantageous in the distribution of endogenous retrovirus data. The distributed nature of the protocol is also found to aid in combining annotation and visualization along a genome in order to enhance the understanding of ERV contribution to its evolution. Reference and annotation servers are conjointly used by eBioX to provide visualization of ERV annotations as well as other data sources. Our DAS data source can be found in the central public DAS service repository, http://www.dasregistry.org, or at http://loka.bmc.uu.se/das/sources.

  3. Validation of Land-Surface Mosaic Heterogeneity in the GEOS DAS

    NASA Technical Reports Server (NTRS)

    Bosilovich, Michael G.; Molod, Andrea; Houser, Paul R.; Schubert, Siegfried

    1999-01-01

    The Mosaic Land-surface Model (LSM) has been included into the current GEOS Data Assimilation System (DAS). The LSM uses a more advanced representation of physical processes than previous versions of the GEOS DAS, including the representation of sub-grid heterogeneity of the land-surface through the Mosaic approach. As a first approximation, Mosaic assumes that all similar surface types within a grid-cell can be lumped together as a single'tile'. Within one GCM grid-cell, there might be 1 - 5 different tiles or surface types. All tiles are subjected to the grid-scale forcing (radiation, air temperature and specific humidity, and precipitation), and the sub-grid variability is a function of the tile characteristics. In this paper, we validate the LSM sub-grid scale variability (tiles) using a variety of surface observing stations from the Southern Great Plains (SGP) site of the Atmospheric Radiation Measurement (ARM) Program. One of the primary goals of SGP ARM is to study the variability of atmospheric radiation within a G,CM grid-cell. Enough surface data has been collected by ARM to extend this goal to sub-grid variability of the land-surface energy and water budgets. The time period of this study is the Summer of 1998 (June I - September 1). The ARM site data consists of surface meteorology, energy flux (eddy correlation and bowen ratio), soil water observations spread over an area similar to the size of a G-CM grid-cell. Various ARM stations are described as wheat and alfalfa crops, pasture and range land. The LSM tiles considered at the grid-space (2 x 2.5) nearest the ARM site include, grassland, deciduous forests, bare soil and dwarf trees. Surface energy and water balances for each tile type are compared with observations. Furthermore, we will discuss the land-surface sub-grid variability of both the ARM observations and the DAS.

  4. Validation of Land-Surface Mosaic Heterogeneity in the GEOS DAS

    NASA Technical Reports Server (NTRS)

    Bosilovich, Michael G.; Molod, Andrea; Houser, Paul R.; Schubert, Siegfried

    1999-01-01

    The Mosaic Land-surface Model (LSM) has been included into the current GEOS Data Assimilation System (DAS). The LSM uses a more advanced representation of physical processes than previous versions of the GEOS DAS, including the representation of sub-grid heterogeneity of the land-surface through the Mosaic approach. As a first approximation, Mosaic assumes that all similar surface types within a grid-cell can be lumped together as a single'tile'. Within one GCM grid-cell, there might be 1 - 5 different tiles or surface types. All tiles are subjected to the grid-scale forcing (radiation, air temperature and specific humidity, and precipitation), and the sub-grid variability is a function of the tile characteristics. In this paper, we validate the LSM sub-grid scale variability (tiles) using a variety of surface observing stations from the Southern Great Plains (SGP) site of the Atmospheric Radiation Measurement (ARM) Program. One of the primary goals of SGP ARM is to study the variability of atmospheric radiation within a G,CM grid-cell. Enough surface data has been collected by ARM to extend this goal to sub-grid variability of the land-surface energy and water budgets. The time period of this study is the Summer of 1998 (June I - September 1). The ARM site data consists of surface meteorology, energy flux (eddy correlation and bowen ratio), soil water observations spread over an area similar to the size of a G-CM grid-cell. Various ARM stations are described as wheat and alfalfa crops, pasture and range land. The LSM tiles considered at the grid-space (2 x 2.5) nearest the ARM site include, grassland, deciduous forests, bare soil and dwarf trees. Surface energy and water balances for each tile type are compared with observations. Furthermore, we will discuss the land-surface sub-grid variability of both the ARM observations and the DAS.

  5. High resolution DAS via sinusoidal frequency scan OFDR (SFS-OFDR).

    PubMed

    Leviatan, Eyal; Eyal, Avishay

    2015-12-28

    There are many advantages to using direct frequency modulation for OFDR based DAS. However, achieving sufficiently linear scan via direct frequency modulation is challenging and poses limits on the scan parameters. A novel method for analyzing sinusoidal frequency modulated light is presented and demonstrated for both static and dynamic sensing. SFS-OFDR projects the measured signal onto appropriate sinusoidal phase terms to obtain spatial information. Thus, by using SFS-OFDR on sinusoidal modulated light it is possible to make use of the many advantages offered by direct frequency modulation without the limitations posed by the linearity requirement.

  6. [An example of partnership cooperation. Cantonal League against Tuberculosis and Lung Diseases/Association "Das Band"].

    PubMed

    Michaelis, E

    1984-01-01

    Together with the Cantonal League against Tuberculosis and Lung Diseases of Zurich, the Association "Das Band" has organized a first course for parents of children with asthma. The course is a component of the associations new "Prophylaxis Program for Children with Asthma and Their Parents". By exchanging ideas, the parents should become able to reflect their situation, characterized by excessive protectionism, aggressiveness, and guiltiness, and they also should learn to accept the disease as a part of their daily life. The first course, which meanwhile is followed by a second one, provided a first base for the solution of the many problems.

  7. GenExp: An Interactive Web-Based Genomic DAS Client with Client-Side Data Rendering

    PubMed Central

    Gel Moreno, Bernat; Messeguer Peypoch, Xavier

    2011-01-01

    Background The Distributed Annotation System (DAS) offers a standard protocol for sharing and integrating annotations on biological sequences. There are more than 1000 DAS sources available and the number is steadily increasing. Clients are an essential part of the DAS system and integrate data from several independent sources in order to create a useful representation to the user. While web-based DAS clients exist, most of them do not have direct interaction capabilities such as dragging and zooming with the mouse. Results Here we present GenExp, a web based and fully interactive visual DAS client. GenExp is a genome oriented DAS client capable of creating informative representations of genomic data zooming out from base level to complete chromosomes. It proposes a novel approach to genomic data rendering and uses the latest HTML5 web technologies to create the data representation inside the client browser. Thanks to client-side rendering most position changes do not need a network request to the server and so responses to zooming and panning are almost immediate. In GenExp it is possible to explore the genome intuitively moving it with the mouse just like geographical map applications. Additionally, in GenExp it is possible to have more than one data viewer at the same time and to save the current state of the application to revisit it later on. Conclusions GenExp is a new interactive web-based client for DAS and addresses some of the short-comings of the existing clients. It uses client-side data rendering techniques resulting in easier genome browsing and exploration. GenExp is open source under the GPL license and it is freely available at http://gralggen.lsi.upc.edu/recerca/genexp. PMID:21750706

  8. Long Noncoding RNA JHDM1D-AS1 Promotes Tumor Growth by Regulating Angiogenesis in Response to Nutrient Starvation.

    PubMed

    Kondo, Ayano; Nonaka, Aya; Shimamura, Teppei; Yamamoto, Shogo; Yoshida, Tetsuo; Kodama, Tatsuhiko; Aburatani, Hiroyuki; Osawa, Tsuyoshi

    2017-09-15

    Long noncoding RNAs play a pivotal role in tumor progression, but their role in cancer cells in the nutrient-starved tumor microenvironment remains unknown. Here, we show that a nutrient starvation-responsive long noncoding RNA, JHDM1D antisense 1 (JHDM1D-AS1), promotes tumorigenesis by regulating angiogenesis in response to nutrient starvation. Expression of JHDM1D-AS1 was increased in cancer cells. In addition, expression of JHDM1D-AS1 was increased in clinical tumor samples compared to that in normal tissue. Stable expression of JHDM1D-AS1 in human pancreatic cancer (PANC-1 and AsPC-1) cells promoted cell growth in vitro Remarkably, these JHDM1D-AS1-expressing cells showed a significant increase in tumor growth in vivo that was associated with increased formation of CD31(+) blood vessels and elevated infiltration of CD11b(+) macrophage lineage cells into tumor tissues. Genome-wide analysis of tumor xenografts revealed that expression of genes for tumor-derived angiogenic factors such as hHGF and hFGF1 concomitant with host-derived inflammation-responsive genes such as mMmp3, mMmp9, mS100a8, and mS100a9 was increased in tumor xenografts of JHDM1D-AS1-expressing pancreatic cancer cells, leading to a poor prognosis. Our results provide evidence that increased JHDM1D-AS1 expression under nutrient starvation accelerates tumor growth by upregulating angiogenesis, thus laying the foundation for improved therapeutic strategies. Copyright © 2017 Kondo et al.

  9. Long Noncoding RNA JHDM1D-AS1 Promotes Tumor Growth by Regulating Angiogenesis in Response to Nutrient Starvation

    PubMed Central

    Kondo, Ayano; Nonaka, Aya; Shimamura, Teppei; Yamamoto, Shogo; Yoshida, Tetsuo; Kodama, Tatsuhiko; Aburatani, Hiroyuki

    2017-01-01

    ABSTRACT Long noncoding RNAs play a pivotal role in tumor progression, but their role in cancer cells in the nutrient-starved tumor microenvironment remains unknown. Here, we show that a nutrient starvation-responsive long noncoding RNA, JHDM1D antisense 1 (JHDM1D-AS1), promotes tumorigenesis by regulating angiogenesis in response to nutrient starvation. Expression of JHDM1D-AS1 was increased in cancer cells. In addition, expression of JHDM1D-AS1 was increased in clinical tumor samples compared to that in normal tissue. Stable expression of JHDM1D-AS1 in human pancreatic cancer (PANC-1 and AsPC-1) cells promoted cell growth in vitro. Remarkably, these JHDM1D-AS1-expressing cells showed a significant increase in tumor growth in vivo that was associated with increased formation of CD31+ blood vessels and elevated infiltration of CD11b+ macrophage lineage cells into tumor tissues. Genome-wide analysis of tumor xenografts revealed that expression of genes for tumor-derived angiogenic factors such as hHGF and hFGF1 concomitant with host-derived inflammation-responsive genes such as mMmp3, mMmp9, mS100a8, and mS100a9 was increased in tumor xenografts of JHDM1D-AS1-expressing pancreatic cancer cells, leading to a poor prognosis. Our results provide evidence that increased JHDM1D-AS1 expression under nutrient starvation accelerates tumor growth by upregulating angiogenesis, thus laying the foundation for improved therapeutic strategies. PMID:28652266

  10. Ocean Color Measurements from Landsat-8 OLI using SeaDAS

    NASA Technical Reports Server (NTRS)

    Franz, Bryan Alden; Bailey, Sean W.; Kuring, Norman; Werdell, P. Jeremy

    2014-01-01

    The Operational Land Imager (OLI) is a multi-spectral radiometer hosted on the recently launched Landsat-8 satellite. OLI includes a suite of relatively narrow spectral bands at 30-meter spatial resolution in the visible to shortwave infrared that make it a potential tool for ocean color radiometry: measurement of the reflected spectral radiance upwelling from beneath the ocean surface that carries information on the biogeochemical constituents of the upper ocean euphotic zone. To evaluate the potential of OLI to measure ocean color, processing support was implemented in SeaDAS, which is an open-source software package distributed by NASA for processing, analysis, and display of ocean remote sensing measurements from a variety of satellite-based multi-spectral radiometers. Here we describe the implementation of OLI processing capabilities within SeaDAS, including support for various methods of atmospheric correction to remove the effects of atmospheric scattering and absorption and retrieve the spectral remote-sensing reflectance (Rrs; sr exp 1). The quality of the retrieved Rrs imagery will be assessed, as will the derived water column constituents such as the concentration of the phytoplankton pigment chlorophyll a.

  11. The development of Music in Dementia Assessment Scales (MiDAS).

    PubMed

    McDermott, Orii; Orrell, Martin; Ridder, Hanne Mette

    2015-07-03

    There is a need to develop an outcome measure specific to music therapy in dementia that reflects a holistic picture of the therapy process and outcome. This study aimed to develop a clinically relevant and scientifically robust music therapy outcome measure incorporating the values and views of people with dementia. Focus groups and interviews were conducted to obtain qualitative data on what music meant to people with dementia and the observed effects of music. Expert and peer consultations were conducted at each stage of the measure development to maximise its content validity. The new measure was field-tested by clinicians in a care home. Feedback from the clinicians and music therapy experts were incorporated during the review and refinement process of the measure. A review of the existing literature, the experiential results and the consensus process enabled the development of the new outcome measure "Music in Dementia Assessment Scales (MiDAS)". Analysis of the qualitative data identified five key areas of the impact of music on people with dementia and they were transformed as the five Visual Analogue Scale (VAS) items: levels of Interest, Response, Initiation, Involvement and Enjoyment. MiDAS comprises the five VAS items and a supplementary checklist of notable positive and negative reactions from the individual. This study demonstrates that it is possible to design and develop an easy to apply and rigorous quantitative outcome measure which has a high level of clinical relevance for people with dementia, care home staff and music therapists.

  12. Trends and variability of climate and river flow in the region of Costa das Baleias, Brazil.

    PubMed

    Genz, F; Tanajura, C A S

    2013-01-01

    There is an ongoing effort by the scientific community to regionalize climate studies to support local development plans. The area of interest is the Costa das Baleias on the east coast of northeast Brazil. It is located in a transition region of precipitation trends, and so assessing the local signal and magnitude is necessary. A series of annual anomalies of surface air temperature, precipitation and river discharge were analyzed from 1946 to 2010. The modified Mann-Kendall test was applied to detect trends. Temperature anomalies showed a consistent positive trend since 1950. Precipitation anomalies tended to decrease, though not significantly. River discharge rates showed a consistent positive trend. However, from the 1980s onwards, both the precipitation and the river discharge anomalies had the same decreasing tendency. The precipitation and discharge behavior are likely due to the combined effect of human interventions in the river basins including local, synoptic and global climate effects. The inter-annual variability was characterized by spectral analysis. Cycles were identified for the precipitation and the river discharge with periods of 2-3 years, 3-4 years, 7-8 years and 11-12 years. The decadal frequency is consistent with the South Atlantic and El Niño indices. This work strongly indicates that climate is changing in Costa das Baleias and further work is needed to investigate the mechanisms that link local to large-scale variability.

  13. The development of Music in Dementia Assessment Scales (MiDAS)

    PubMed Central

    McDermott, Orii; Orrell, Martin; Ridder, Hanne Mette

    2015-01-01

    There is a need to develop an outcome measure specific to music therapy in dementia that reflects a holistic picture of the therapy process and outcome. This study aimed to develop a clinically relevant and scientifically robust music therapy outcome measure incorporating the values and views of people with dementia. Focus groups and interviews were conducted to obtain qualitative data on what music meant to people with dementia and the observed effects of music. Expert and peer consultations were conducted at each stage of the measure development to maximise its content validity. The new measure was field-tested by clinicians in a care home. Feedback from the clinicians and music therapy experts were incorporated during the review and refinement process of the measure. A review of the existing literature, the experiential results and the consensus process enabled the development of the new outcome measure “Music in Dementia Assessment Scales (MiDAS)”. Analysis of the qualitative data identified five key areas of the impact of music on people with dementia and they were transformed as the five Visual Analogue Scale (VAS) items: levels of Interest, Response, Initiation, Involvement and Enjoyment. MiDAS comprises the five VAS items and a supplementary checklist of notable positive and negative reactions from the individual. This study demonstrates that it is possible to design and develop an easy to apply and rigorous quantitative outcome measure which has a high level of clinical relevance for people with dementia, care home staff and music therapists. PMID:26246670

  14. Genome-wide analysis of in vivo binding of the master regulator DasR in Streptomyces coelicolor identifies novel non-canonical targets.

    PubMed

    Świątek-Połatyńska, Magdalena A; Bucca, Giselda; Laing, Emma; Gubbens, Jacob; Titgemeyer, Fritz; Smith, Colin P; Rigali, Sébastien; van Wezel, Gilles P

    2015-01-01

    Streptomycetes produce a wealth of natural products, including over half of all known antibiotics. It was previously demonstrated that N-acetylglucosamine and secondary metabolism are closely entwined in streptomycetes. Here we show that DNA recognition by the N-acetylglucosamine-responsive regulator DasR is growth-phase dependent, and that DasR can bind to sites in the S. coelicolor genome that have no obvious resemblance to previously identified DasR-responsive elements. Thus, the regulon of DasR extends well beyond what was previously predicted and includes a large number of genes with functions far removed from N-acetylglucosamine metabolism, such as genes for small RNAs and DNA transposases. Conversely, the DasR regulon during vegetative growth largely correlates to the presence of canonical DasR-responsive elements. The changes in DasR binding in vivo following N-acetylglucosamine induction were studied in detail and a possible molecular mechanism by which the influence of DasR is extended is discussed. Discussion of DasR binding was further informed by a parallel transcriptome analysis of the respective cultures. Evidence is provided that DasR binds directly to the promoters of all genes encoding pathway-specific regulators of antibiotic production in S. coelicolor, thereby providing an exquisitely simple link between nutritional control and secondary metabolism.

  15. A causa das estações do ano: modelos mentais

    NASA Astrophysics Data System (ADS)

    de Campos, J. A. S.; de Araujo, J. F. S.

    2003-08-01

    A década de 70 do século passado foi marcada pelo estudo das concepções alternativas que os alunos trazem para a sala de aula. A identificação destas concepções foi o ponto de partida para promover a mudança conceitual, onde as pré-concepções seriam trocadas pelas concepções científicas. Na década seguinte, surgiram muitas propostas de estratégias educacionais para facilitar esta troca, na sua maioria baseadas na idéia do conflito cognitivo, proposta por Piaget. Entretanto, os resultados pouco animadores conduziram à percepção de que a mudança conceitual é um processo mais complexo. Pelas idéias da Ciência Cognitiva, a mudança conceitual é uma mudança progressiva dos modelos mentais que o aluno tem sobre o mundo físico, através de enriquecimento e revisão. A causa das Estações do Ano é um tópico sobre o qual a maioria dos estudantes apresenta concepções alternativas. Os autores fizeram um levantamento sobre as pré-concepções encontradas em trabalhos sobre o tema (16 referências), procurando encontrar elementos comuns que indicassem a presença de modelos mentais específicos. As pré-concepções encontradas na literatura foram obtidas usando-se diversas metodologias (desde entrevistas clínicas até questionários de múltipla escolha) e envolvendo alunos e professores de diferentes regiões geográficas. A partir de uma análise aprofundada de cada trabalho, e utilizando-se a técnica das Redes Sistêmicas, chegou-se a conclusão que as diversas pré-concepções identificadas (em torno de 50), poderiam ser representadas por 6 modelos mentais, onde a explicação da causa das estações do ano tem um mecanismo causal responsável. Os mecanismos causais identificados foram: a dependência da distância, a dependência da orientação, a dependência conjunta da distância e orientação, a dependência da obstrução, a dependência da velocidade e a dependência da inclinação dos raios solares. Foram ainda identificadas

  16. Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene

    PubMed Central

    Lee, Hyunah; Nam, Donggyu; Choi, Jae-Kyung; Araúzo-Bravo, Marcos J.; Kwon, Soon-Yong; Zaehres, Holm; Lee, Taehee; Park, Chan Young; Kang, Hyun-Wook; Schöler, Hans R.; Kim, Jeong Beom

    2016-01-01

    The maintenance of undifferentiated human pluripotent stem cells (hPSC) under xeno-free condition requires the use of human feeder cells or extracellular matrix (ECM) coating. However, human-derived sources may cause human pathogen contamination by viral or non-viral agents to the patients. Here we demonstrate feeder-free and xeno-free culture system for hPSC expansion using diffusion assisted synthesis-grown nanocrystalline graphene (DAS-NG), a synthetic non-biological nanomaterial which completely rule out the concern of human pathogen contamination. DAS-NG exhibited advanced biocompatibilities including surface nanoroughness, oxygen containing functional groups and hydrophilicity. hPSC cultured on DAS-NG could maintain pluripotency in vitro and in vivo, and especially cell adhesion-related gene expression profile was comparable to those of cultured on feeders, while hPSC cultured without DAS-NG differentiated spontaneously with high expression of somatic cell-enriched adhesion genes. This feeder-free and xeno-free culture method using DAS-NG will facilitate the generation of clinical-grade hPSC. PMID:26846167

  17. Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene

    NASA Astrophysics Data System (ADS)

    Lee, Hyunah; Nam, Donggyu; Choi, Jae-Kyung; Araúzo-Bravo, Marcos J.; Kwon, Soon-Yong; Zaehres, Holm; Lee, Taehee; Park, Chan Young; Kang, Hyun-Wook; Schöler, Hans R.; Kim, Jeong Beom

    2016-02-01

    The maintenance of undifferentiated human pluripotent stem cells (hPSC) under xeno-free condition requires the use of human feeder cells or extracellular matrix (ECM) coating. However, human-derived sources may cause human pathogen contamination by viral or non-viral agents to the patients. Here we demonstrate feeder-free and xeno-free culture system for hPSC expansion using diffusion assisted synthesis-grown nanocrystalline graphene (DAS-NG), a synthetic non-biological nanomaterial which completely rule out the concern of human pathogen contamination. DAS-NG exhibited advanced biocompatibilities including surface nanoroughness, oxygen containing functional groups and hydrophilicity. hPSC cultured on DAS-NG could maintain pluripotency in vitro and in vivo, and especially cell adhesion-related gene expression profile was comparable to those of cultured on feeders, while hPSC cultured without DAS-NG differentiated spontaneously with high expression of somatic cell-enriched adhesion genes. This feeder-free and xeno-free culture method using DAS-NG will facilitate the generation of clinical-grade hPSC.

  18. Measuring Primary Teachers' Attitudes Toward Teaching Science: Development of the Dimensions of Attitude Toward Science (DAS) Instrument

    NASA Astrophysics Data System (ADS)

    van Aalderen-Smeets, Sandra; Walma van der Molen, Juliette

    2013-03-01

    In this article, we present a valid and reliable instrument which measures the attitude of in-service and pre-service primary teachers toward teaching science, called the Dimensions of Attitude Toward Science (DAS) Instrument. Attention to the attitudes of primary teachers toward teaching science is of fundamental importance to the professionalization of these teachers in the field of primary science education. With the development of this instrument, we sought to fulfill the need for a statistically and theoretically valid and reliable instrument to measure pre-service and in-service teachers' attitudes. The DAS Instrument is based on a comprehensive theoretical framework for attitude toward (teaching) science. After pilot testing, the DAS was revised and subsequently validated using a large group of respondents (pre-service and in-service primary teachers) (N = 556). The theoretical underpinning of the DAS combined with the statistical data indicate that the DAS possesses good construct validity and that it proves to be a promising instrument that can be utilized for research purposes, and also as a teacher training and coaching tool. This instrument can therefore make a valuable contribution to progress within the field of science education.

  19. Subchronic feeding study with genetically modified stacked trait lepidopteran and coleopteran resistant (DAS-Ø15Ø7-1xDAS-59122-7) maize grain in Sprague-Dawley rats.

    PubMed

    Appenzeller, Laura M; Malley, Linda; Mackenzie, Susan A; Hoban, Denise; Delaney, Bryan

    2009-07-01

    DAS-Ø15Ø7-1xDAS-59122-7 (1507x59122) is a genetically modified (GM) maize hybrid that was produced by crossing of two GM maize inbreds; DAS-Ø15Ø7-1 and DAS-59122-7. This hybrid cross expresses four transgenic proteins: Cry1F and PAT (from DAS-Ø15Ø7-1) and Cry34Ab1/Cry35Ab1 and PAT (from DAS-59122-7) that confer resistance to lepidopteran and coleopteran pests and tolerance to the herbicidal active ingredient glufosinate-ammonium. The current subchronic feeding study was conducted in Sprague-Dawley rats to evaluate the potential health effects of long-term consumption of a rodent diet containing 1507x59122 maize grain compared with a diet containing maize grain from its near-isogenic control (091). Diets formulated with three unrelated non-GM commercial hybrids (3573, 35P12, 36G12) were also included for within study reference data. All diets contained 34% (w/wt) maize grain and were prepared according to the specifications of PMI((R)) Nutrition International, LLC Certified Rodent LabDiet((R)) 5002 (PMI((R)) 5002). Diets were fed ad libitum to rats for at least 92days. OECD 408 response variables from rats fed the 1507x59122 diet were compared with those from rats fed the 091 control diet. No toxicologically significant differences were observed in nutritional performance variables, clinical and neurobehavioral signs, ophthalmology, clinical pathology (hematology, clinical chemistry, coagulation, and urinalysis), organ weights, and gross and microscopic pathology between rats in the 091 and 1507x59122 treatment groups. The results from this study demonstrate that 1507x59122 maize grain is as safe and nutritious as non-GM maize grain and support the concept that crossing of two safe GM maize events results in production of a safe stacked GM event.

  20. Análise da cinemática interna das regiões HII gigantes e das galáxias HII

    NASA Astrophysics Data System (ADS)

    Plana, H.; Telles, E.; Maíz-Apellániz, J.

    2003-08-01

    Neste trabalho nós mostramos os primeiros resultados de um estudo sobre a cinemática das Regiões HII Gigantes (GHIIRs) em galáxias próximas. Essas regiões HII têm um diâmetro médio entre 100 pc e 1000 pc e uma taxa de formação estelar de 106 M¤ / ano sendo equivalente à observada em galáxias de tipo tardio correspondendo a uma taxa de formação estelar por unidade de volume uma ordem de magnitude maior que a observada em regiões HII normais. Usando espectros de fenda longas em várias posições, nós construímos mapas de velocidades, de dispersão e de intensidade para várias linhas de emissão como Ha, Hb, [NII]6584 Å, [OIII]5007 Å e o doublet de [SII], para cinco regiões gigantes: NGC 2403 II e IV, NGC 595, NGC 5461, NGC 5471, NGC 5455. O estudo da cinemática (mapas de velocidades e da dispersão) mostrou, por exemplo, a presença de cascas em expansão em NGC 595 ou perfis de emissão com várias componentes em NGC 5461. Os perfis de emissão também mostram velocidades supersônicas. Os resultados são discutidos em comparação com os de estudos anteriores realizados.

  1. DasPy – Open Source Multivariate Land Data Assimilation Framework with High Performance Computing

    NASA Astrophysics Data System (ADS)

    Han, Xujun; Li, Xin; Montzka, Carsten; Kollet, Stefan; Vereecken, Harry; Hendricks Franssen, Harrie-Jan

    2015-04-01

    Data assimilation has become a popular method to integrate observations from multiple sources with land surface models to improve predictions of the water and energy cycles of the soil-vegetation-atmosphere continuum. In recent years, several land data assimilation systems have been developed in different research agencies. Because of the software availability or adaptability, these systems are not easy to apply for the purpose of multivariate land data assimilation research. Multivariate data assimilation refers to the simultaneous assimilation of observation data for multiple model state variables into a simulation model. Our main motivation was to develop an open source multivariate land data assimilation framework (DasPy) which is implemented using the Python script language mixed with C++ and Fortran language. This system has been evaluated in several soil moisture, L-band brightness temperature and land surface temperature assimilation studies. The implementation allows also parameter estimation (soil properties and/or leaf area index) on the basis of the joint state and parameter estimation approach. LETKF (Local Ensemble Transform Kalman Filter) is implemented as the main data assimilation algorithm, and uncertainties in the data assimilation can be represented by perturbed atmospheric forcings, perturbed soil and vegetation properties and model initial conditions. The CLM4.5 (Community Land Model) was integrated as the model operator. The CMEM (Community Microwave Emission Modelling Platform), COSMIC (COsmic-ray Soil Moisture Interaction Code) and the two source formulation were integrated as observation operators for assimilation of L-band passive microwave, cosmic-ray soil moisture probe and land surface temperature measurements, respectively. DasPy is parallelized using the hybrid MPI (Message Passing Interface) and OpenMP (Open Multi-Processing) techniques. All the input and output data flow is organized efficiently using the commonly used NetCDF file

  2. Integriertes Informationsmanagement an der Westfälischen Wilhelms-Universität Münster - Das Projekt MIRO

    NASA Astrophysics Data System (ADS)

    Vogl, Raimund; Gildhorn, Antje; Labitzke, Jörg; Wibberg, Michael

    An der Westfälischen Wilhelms-Universität Münster (WWU) wurde bereits 1996 ein tragfähiges, kooperativ ausgerichtetes System der IT-Governance im Zusammenspiel zentraler und dezentraler IT-Leistungserbringer etabliert. Um den Anforderungen an ein integriertes Informationsmanagement im Überlappungsfeld von Information, Kommunikation und Medien (IKM) durch das Zusammenspiel der zentralen Einrichtungen Universitätsverwaltung (UniV), Universitäts- und Landesbibliothek (ULB) und Zentrum für Informationsverarbeitung (ZIV) gerecht zu werden, wurde 2003 der IKM-Service institutionalisiert. In diesem Rahmen wurde das Projekt Münster Information System for Research and Organization (MIRO) entwickelt, das als Leistungszentrum für Forschungsinformation von der DFG gefördert wird. Die bisherigen Projekterfahrungen, erreichten Ziele und verbleibenden Aufgaben werden dargestellt. Im Projektverlauf haben sich insbesondere die etablierten IT-Governance und Versorgungs-Strukturen sowie die Unterstützung der Hochschulleitung als essentielle Erfolgskriterien erwiesen.

  3. Viscous dissipation effects on unsteady mixed convective stagnation point flow using Tiwari-Das nanofluid model

    NASA Astrophysics Data System (ADS)

    Mabood, F.; Ibrahim, S. M.; Kumar, P. V.; Khan, W. A.

    A mathematical model has been developed using Tiwari-Das model to study the MHD stagnation-point flow and heat transfer characteristics of an electrically conducting nanofluid over a vertical permeable shrinking/stretching sheet in the presence of viscous dissipation. Formulated partial differential equations are converted into a set of ordinary differential equations using suitable similarity transformation. Runge-Kutta-Fehlberg method with shooting technique is applied to solve the resulting coupled ordinary differential equations. The profiles for velocity, temperature, skin friction coefficient and local Nusselt number for various parameters are displayed through graphs and tabular forms. In this problem, we considered two types of nanoparticles, namely, copper (Cu) and Alumina (Al2O3) with water as base fluid.

  4. Event DAS-444Ø6-6 soybean grown in Brazil is compositionally equivalent to non-transgenic soybean.

    PubMed

    Fast, Brandon J; Galan, Maria P; Schafer, Ariane C

    2016-04-02

    Soybean event DAS-444Ø6-6 is tolerant to the herbicides 2,4-D, glyphosate, and glufosinate. An investigation of potential unintended adverse compositional changes in a genetically modified crop is required to meet government regulatory requirements in various geographies. A study to meet these requirements in Brazil was completed demonstrating compositional equivalency between DAS-444Ø6-6 and non-transgenic soybean. This study supplements the extensive literature supporting transgenesis as less disruptive of crop composition compared with traditional breeding methods.

  5. Event DAS-444Ø6-6 soybean grown in Brazil is compositionally equivalent to non-transgenic soybean

    PubMed Central

    Fast, Brandon J.; Galan, Maria P.; Schafer, Ariane C.

    2016-01-01

    ABSTRACT Soybean event DAS-444Ø6-6 is tolerant to the herbicides 2,4-D, glyphosate, and glufosinate. An investigation of potential unintended adverse compositional changes in a genetically modified crop is required to meet government regulatory requirements in various geographies. A study to meet these requirements in Brazil was completed demonstrating compositional equivalency between DAS-444Ø6-6 and non-transgenic soybean. This study supplements the extensive literature supporting transgenesis as less disruptive of crop composition compared with traditional breeding methods. PMID:27248569

  6. Sobre o uso das séries de Puiseux em mecanica celeste

    NASA Astrophysics Data System (ADS)

    Miloni, O. I.

    2003-08-01

    Neste trabalho é apresentada uma demonstração do uso dos diferentes desenvolvimentos em séries para as equações de perturbação em Mecânica Celeste no marco Hamiltoniano. Em trabalhos clássicos como os de Poincaré (Poincaré, 1893) por exemplo, já esta planteado o uso de potências não inteiras no pequeno parâmetro, o que evidencia a não analiticidade das funções quando uma ressonância ocorre. Nestes trabalhos os desenvolvimentos são na raíz quadrada da massa de Júpiter (o pequeno parâmetro). Mais recentemente (Ferraz-Mello, 1985) outros tipos de desenvolvimentos foram aplicados modificando substancialmente as ordens de grandeza e a velocidade de convergência das séries. Com esta abordagem, os desenvolvimentos foram expressados em termos da raíz cúbica do pequeno parâmetro. Neste trabalho apresentamos um enfoque geral, onde os diferentes tipos de desenvolvimentos em séries de Puiseux (Valiron, 1950) são obtidos a partir da aplicação de Teorema de Preparação de Weierstrass (Goursat, 1916) considerando a equação de Hamilton-Jacobi como uma equação algébrica. Os resultados são aplicados ao problema restrito dos três corpos em ressonância de primeira ordem e, dependendo da grandeza da excentricidade do asteróide em relação à de Júpiter, obtemos os diferentes desenvolvimentos, em raíz quadrada ou raíz cúbica da massa de Júpiter.

  7. Test Review: Naglieri, J. A., Das, J. P., & Goldstein, S. (2014). Cognitive Assessment System-Second Edition (2nd Ed.)

    ERIC Educational Resources Information Center

    McGill, Ryan J.

    2015-01-01

    The Cognitive Assessment System-Second Edition (CAS2) is an individually administered measure of cognitive ability designed for children and adolescents ages 5 through 18 years. The measure, authored by Jack A. Naglieri, J. P. Das, and Sam Goldstein, was published by Pro-Ed in 2014 and is the first revision of the Cognitive Assessment System (CAS;…

  8. Latent Factor Structure of the Das-Naglieri Cognitive Assessment System: A Confirmatory Factor Analysis in a Chinese Setting

    ERIC Educational Resources Information Center

    Deng, Ci-ping; Liu, Ming; Wei, Wei; Chan, Raymond C. K.; Das, J. P.

    2011-01-01

    This study aims to measure the psychometric properties of the Das-Naglieri Cognitive Assessment System (D-N CAS) and to determine its clinical utility in a Chinese context. Confirmatory factor analysis (CFA) was conducted to examine the construct validity of the Chinese version of the D-N CAS among a group of 567, normally developed children.…

  9. Processing data for a spatial watershed model to evaluate hydrological responses of the Ribeirão das Posses, Brazil

    USDA-ARS?s Scientific Manuscript database

    Southeastern Brazil has experienced drought conditions that have impacted the conservation of watersheds and the management of water quality and quantity for agricultural and urban demands. The Ribeirão das Posses watershed is being monitored as a headwater of the Jaguarí River, which is one of the ...

  10. Concurrent Validity of the WISC-IV and DAS-II in Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Kuriakose, Sarah

    2014-01-01

    Cognitive assessments are used for a variety of research and clinical purposes in children with autism spectrum disorder (ASD). This study establishes concurrent validity of the Wechsler Intelligence Scales for Children-fourth edition (WISC-IV) and Differential Ability Scales-second edition (DAS-II) in a sample of children with ASD with a broad…

  11. OntoDas – a tool for facilitating the construction of complex queries to the Gene Ontology

    PubMed Central

    O'Neill, Kieran; Garcia, Alexander; Schwegmann, Anita; Jimenez, Rafael C; Jacobson, Dan; Hermjakob, Henning

    2008-01-01

    Background Ontologies such as the Gene Ontology can enable the construction of complex queries over biological information in a conceptual way, however existing systems to do this are too technical. Within the biological domain there is an increasing need for software that facilitates the flexible retrieval of information. OntoDas aims to fulfil this need by allowing the definition of queries by selecting valid ontology terms. Results OntoDas is a web-based tool that uses information visualisation techniques to provide an intuitive, interactive environment for constructing ontology-based queries against the Gene Ontology Database. Both a comprehensive use case and the interface itself were designed in a participatory manner by working with biologists to ensure that the interface matches the way biologists work. OntoDas was further tested with a separate group of biologists and refined based on their suggestions. Conclusion OntoDas provides a visual and intuitive means for constructing complex queries against the Gene Ontology. It was designed with the participation of biologists and compares favourably with similar tools. It is available at PMID:18925933

  12. Measuring Primary Teachers' Attitudes toward Teaching Science: Development of the Dimensions of Attitude toward Science (DAS) Instrument

    ERIC Educational Resources Information Center

    van Aalderen-Smeets, Sandra; Walma van der Molen, Juliette

    2013-01-01

    In this article, we present a valid and reliable instrument which measures the attitude of in-service and pre-service primary teachers toward teaching science, called the Dimensions of Attitude Toward Science (DAS) Instrument. Attention to the attitudes of primary teachers toward teaching science is of fundamental importance to the…

  13. Test Review: Naglieri, J. A., Das, J. P., & Goldstein, S. (2014). Cognitive Assessment System-Second Edition (2nd Ed.)

    ERIC Educational Resources Information Center

    McGill, Ryan J.

    2015-01-01

    The Cognitive Assessment System-Second Edition (CAS2) is an individually administered measure of cognitive ability designed for children and adolescents ages 5 through 18 years. The measure, authored by Jack A. Naglieri, J. P. Das, and Sam Goldstein, was published by Pro-Ed in 2014 and is the first revision of the Cognitive Assessment System (CAS;…

  14. Concurrent Validity of the WISC-IV and DAS-II in Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Kuriakose, Sarah

    2014-01-01

    Cognitive assessments are used for a variety of research and clinical purposes in children with autism spectrum disorder (ASD). This study establishes concurrent validity of the Wechsler Intelligence Scales for Children-fourth edition (WISC-IV) and Differential Ability Scales-second edition (DAS-II) in a sample of children with ASD with a broad…

  15. Measuring Primary Teachers' Attitudes toward Teaching Science: Development of the Dimensions of Attitude toward Science (DAS) Instrument

    ERIC Educational Resources Information Center

    van Aalderen-Smeets, Sandra; Walma van der Molen, Juliette

    2013-01-01

    In this article, we present a valid and reliable instrument which measures the attitude of in-service and pre-service primary teachers toward teaching science, called the Dimensions of Attitude Toward Science (DAS) Instrument. Attention to the attitudes of primary teachers toward teaching science is of fundamental importance to the…

  16. Expression of Das-1, Ki67 and sulfuric proteins in gastric cardia adenocarcinoma and intestinal metaplasia lesions

    PubMed Central

    FENG, XIAO-SHAN; WANG, YU-FENG; HAO, SHU-GUANG; RU, YI; GAO, SHE-GAN; WANG, LI-DONG

    2013-01-01

    The aim of this study was to characterize histo-chemical patterns and Das-1 and Ki67 protein expression in gastric cardia adenocarcinoma (GCA) and intestinal metaplasia (IM) lesions adjacent to GCA. Histochemical techniques, including Alcian blue/periodic acid-Schiff (AB/PAS), high iron diamine/Alcian blue (HID/AB) and avidin-biotin-peroxidase complex (ABC) immunohistochemistry were applied to GCA and IM samples from patients (n=200) in Linzhou, Henan, China, a high incidence area for GCA and esophageal squamous cell carcinoma (SCC). The detection rate of IM lesions in resected tissues adjacent to GCA was 32.5% (65/200). GCA and IM lesions presented a high frequency of Das-1 and Ki67-positive staining with statistical significance (P<0.01). The expression of sulfuric proteins did not show co-expression with Das-1 and Ki67 in GCA and surrounding IM lesions (P>0.05) from the same GCA patient. The high frequency of co-expression of Das-1 and Ki67 in GCA and adjacent IM lesions indicates that IM adjacent to GCA may undergo similar molecular changes to GCA, which may be one of the mechanisms for malignant transformation of IM in the population studied. PMID:23837030

  17. Planning Ability across Ranges of Intellectual Ability: An Examination of the Luria-Das Information-Processing Model.

    ERIC Educational Resources Information Center

    McCallum, R. Steve; And Others

    1988-01-01

    Based on Luria-Das information processing theory, hypothesized that 26 educable mentally retarded children would score significantly less well on relatively pure measures of planning ability than would 13 younger average ability students after students were matched on cognitive processing ability. Hypothesis was not supported by study. (Author/NB)

  18. Latent Factor Structure of the Das-Naglieri Cognitive Assessment System: A Confirmatory Factor Analysis in a Chinese Setting

    ERIC Educational Resources Information Center

    Deng, Ci-ping; Liu, Ming; Wei, Wei; Chan, Raymond C. K.; Das, J. P.

    2011-01-01

    This study aims to measure the psychometric properties of the Das-Naglieri Cognitive Assessment System (D-N CAS) and to determine its clinical utility in a Chinese context. Confirmatory factor analysis (CFA) was conducted to examine the construct validity of the Chinese version of the D-N CAS among a group of 567, normally developed children.…

  19. Impaired Left Ventricular Diastolic Functions and Thickened Epicardial Adipose Tissue in Rheumatoid Arthritis Patients is Correlated with DAS-28 Score

    PubMed Central

    Alpaydın, Sertac; Buyukterzi, Zafer; Akkurt, Halil Ekrem; Yılmaz, Halim

    2017-01-01

    Background Rheumatoid arthritis (RA) is a chronic inflammatory disease that is known to be associated with high cardiovascular (CV) morbidity and mortality. In this study, we aimed to demonstrate whether RA disease activity reflected with disease activity score-28 (DAS-28) had an impact on left ventricular diastolic functions and epicardial adipose tissue (EAT) thickness in RA patients with no traditional CV risk factors. Methods In this retrospective study, 41 patients newly diagnosed with RA were included. In addition to medical history, detailed physical examination findings and laboratory tests, left ventricular systolic and diastolic functions, chamber dimensions, and EAT thickness were evaluated with transthoracic echocardiography in the study population. Results This study included 41 subjects with a median age of 45 years (38.00-55.50), of which 29.27% were male. In the binomial logistic regression analysis, DAS-28 score was found to be an independent associate of diastolic dysfunction, Additionally, DAS-28 was found to be independently associated with EAT thickness. Conclusions Patients with high DAS-28 score should be evaluated thoroughly for CV disease, and patients should undergo advanced diagnostic studies as required and receive appropriate treatment. PMID:28344422

  20. Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: a longitudinal observational study.

    PubMed

    Lee, Yvonne C; Cui, Jing; Lu, Bing; Frits, Michelle L; Iannaccone, Christine K; Shadick, Nancy A; Weinblatt, Michael E; Solomon, Daniel H

    2011-06-08

    Disease remission has become a feasible goal for most rheumatoid arthritis (RA) patients; however, patient-reported symptoms, such as pain, may persist despite remission. We assessed the prevalence of pain in RA patients in remission according to the Disease Activity Score (DAS28-CRP4) and the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) remission criteria. Data were analyzed from RA patients in the Brigham Rheumatoid Arthritis Sequential Study with data at baseline and 1 year. DAS28 remission was defined as DAS28-CRP4 <2.6. The ACR/EULAR remission criteria included (a) one or more swollen joints, (b) one or more tender joints, (c) C-reactive protein ≤1 mg/dl, and (d) patient global assessment score ≤1. Pain severity was measured by using the pain score from the Multi-Dimensional Health Assessment Questionnaire (MDHAQ). The associations between baseline clinical predictors and MDHAQ pain at baseline and 1 year were assessed by using multivariable linear regression. Among the 865 patients with data at baseline and 1 year, 157 (18.2%) met DAS28-CRP4 remission criteria at both time points. Thirty-seven (4.3%) met the ACR/EULAR remission criteria at baseline and 1 year. The prevalence of clinically significant pain (MDHAQ pain ≥4) at baseline ranged from 11.9% among patients meeting DAS28-CRP4 remission criteria to none among patients meeting ACR/EULAR remission criteria. Patient global assessment, MDHAQ function, MDHAQ fatigue, MDHAQ sleep, and arthritis self-efficacy were significantly associated with MDHAQ pain in cross-sectional (P ≤ 0.0005) and longitudinal analyses (P ≤ 0.03). Low swollen-joint counts were associated with high MDHAQ pain in longitudinal analyses (P = 0.02) but not cross-sectional analyses. Other measures of inflammatory disease activity and joint damage were not significantly associated with MDHAQ pain at baseline or at 1 year. Clinically significant pain continues among a substantial proportion of

  1. Phase Velocity and Full-Waveform Analysis of Co-located Distributed Acoustic Sensing (DAS) Channels and Geophone Sensor

    NASA Astrophysics Data System (ADS)

    Parker, L.; Mellors, R. J.; Thurber, C. H.; Wang, H. F.; Zeng, X.

    2015-12-01

    A 762-meter Distributed Acoustic Sensing (DAS) array with a channel spacing of one meter was deployed at the Garner Valley Downhole Array in Southern California. The array was approximately rectangular with dimensions of 180 meters by 80 meters. The array also included two subdiagonals within the rectangle along which three-component geophones were co-located. Several active sources were deployed, including a 45-kN, swept-frequency, shear-mass shaker, which produced strong Rayleigh waves across the array. Both DAS and geophone traces were filtered in 2-Hz steps between 4 and 20 Hz to obtain phase velocities as a function of frequency from fitting the moveout of travel times over distances of 35 meters or longer. As an alternative to this traditional means of finding phase velocity, it is theoretically possible to find the Rayleigh-wave phase velocity at each point of co-location as the ratio of DAS and geophone responses, because DAS is sensitive to ground strain and geophones are sensitive to ground velocity, after suitable corrections for instrument response (Mikumo & Aki, 1964). The concept was tested in WPP, a seismic wave propagation program, by first validating and then using a 3D synthetic, full-waveform seismic model to simulate the effect of increased levels of noise and uncertainty as data go from ideal to more realistic. The results obtained from this study provide a better understanding of the DAS response and its potential for being combined with traditional seismometers for obtaining phase velocity at a single location. This analysis is part of the PoroTomo project (Poroelastic Tomography by Adjoint Inverse Modeling of Data from Seismology, Geodesy, and Hydrology, http://geoscience.wisc.edu/feigl/porotomo).

  2. DAS181 for Treatment of Parainfluenza Virus Infections in Hematopoietic Stem Cell Transplant Recipients at a Single Center.

    PubMed

    Salvatore, Mirella; Satlin, Michael J; Jacobs, Samantha E; Jenkins, Stephen G; Schuetz, Audrey N; Moss, Ronald B; Van Besien, Koen; Shore, Tsiporah; Soave, Rosemary

    2016-05-01

    Parainfluenza virus (PIV) causes severe respiratory infections in hematopoietic stem cell transplant (HSCT) recipients. Currently, no effective therapies are available. DAS181 is a novel antiviral agent that inhibits attachment of PIV to respiratory cells, but clinical data on the use of DAS181 for PIV infection are limited to case reports. We report the clinical manifestations and outcomes of 16 HSCT recipients who received DAS181 daily for the treatment of PIV infection through a compassionate-use protocol or a single-arm clinical trial. Of the 16 patients (clinical trial: 9; compassionate use: 7), 13 were allogeneic HSCT recipients and 8 had graft-versus-host disease. PIV types were 3 (n = 7), 4 (n = 5), 1 (n = 3), and type 3 and 4 coinfection (n = 1). Fourteen patients had pneumonia. All patients presented with cough, 14 had dyspnea, 11 had hypoxia, and 8 had a fever. Patients received 5 to 10 days of treatment. Nine patients (56%) had a complete clinical response after DAS181 therapy and 4 (25%) had a partial response. The 3 patients without a clinical response had coinfections with other pathogens. Of the 7 patients with virologic and spirometric data, 5 had >1-log reduction in nasopharyngeal swab PIV viral load and 4 had improved forced expiratory volumes by the end of treatment. Three patients (19%) died within 30 days and 2 of these deaths were related to PIV infection. Our data suggest that DAS181 may be an effective therapy for PIV pneumonia in HSCT recipients. Randomized placebo-controlled trials are needed to better evaluate its efficacy.

  3. (Re)locating (I)dentity With(in) Politicized (Re)presentation of Fe/Male Body in Kamala Das' Poetry

    ERIC Educational Resources Information Center

    Sultana, Sharmin; Sarwar, Nadia

    2016-01-01

    This paper is going to argue that the selected poems of renowned Indian poet Kamala Das are inclined to relocate both feminine and masculine identity through the politicized representation of body. Kamala Das' representation of body in her poems has always been viewed as a medium of re-historicizing the pain, sufferings, and psychological trauma…

  4. Crystal Structures of the Global Regulator DasR from Streptomyces coelicolor: Implications for the Allosteric Regulation of GntR/HutC Repressors

    PubMed Central

    Fillenberg, Simon B.; Friess, Mario D.; Körner, Samuel; Böckmann, Rainer A.; Muller, Yves A.

    2016-01-01

    Small molecule effectors regulate gene transcription in bacteria by altering the DNA-binding affinities of specific repressor proteins. Although the GntR proteins represent a large family of bacterial repressors, only little is known about the allosteric mechanism that enables their function. DasR from Streptomyces coelicolor belongs to the GntR/HutC subfamily and specifically recognises operators termed DasR-responsive elements (dre-sites). Its DNA-binding properties are modulated by phosphorylated sugars. Here, we present several crystal structures of DasR, namely of dimeric full-length DasR in the absence of any effector and of only the effector-binding domain (EBD) of DasR without effector or in complex with glucosamine-6-phosphate (GlcN-6-P) and N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Together with molecular dynamics (MD) simulations and a comparison with other GntR/HutC family members these data allowed for a structural characterisation of the different functional states of DasR. Allostery in DasR and possibly in many other GntR/HutC family members is best described by a conformational selection model. In ligand-free DasR, an increased flexibility in the EBDs enables the attached DNA-binding domains (DBD) to sample a variety of different orientations and among these also a DNA-binding competent conformation. Effector binding to the EBDs of DasR significantly reorganises the atomic structure of the latter. However, rather than locking the orientation of the DBDs, the effector-induced formation of β-strand β* in the DBD-EBD-linker segment merely appears to take the DBDs ‘on a shorter leash’ thereby impeding the ‘downwards’ positioning of the DBDs that is necessary for a concerted binding of two DBDs of DasR to operator DNA. PMID:27337024

  5. Common Data Acquisition Systems (DAS) Software Development for Rocket Propulsion Test (RPT) Test Facilities

    NASA Technical Reports Server (NTRS)

    Hebert, Phillip W., Sr.; Davis, Dawn M.; Turowski, Mark P.; Holladay, Wendy T.; Hughes, Mark S.

    2012-01-01

    The advent of the commercial space launch industry and NASA's more recent resumption of operation of Stennis Space Center's large test facilities after thirty years of contractor control resulted in a need for a non-proprietary data acquisition systems (DAS) software to support government and commercial testing. The software is designed for modularity and adaptability to minimize the software development effort for current and future data systems. An additional benefit of the software's architecture is its ability to easily migrate to other testing facilities thus providing future commonality across Stennis. Adapting the software to other Rocket Propulsion Test (RPT) Centers such as MSFC, White Sands, and Plumbrook Station would provide additional commonality and help reduce testing costs for NASA. Ultimately, the software provides the government with unlimited rights and guarantees privacy of data to commercial entities. The project engaged all RPT Centers and NASA's Independent Verification & Validation facility to enhance product quality. The design consists of a translation layer which provides the transparency of the software application layers to underlying hardware regardless of test facility location and a flexible and easily accessible database. This presentation addresses system technical design, issues encountered, and the status of Stennis development and deployment.

  6. The Trigger and Data Acquisition System (TriDAS) of the KM3NeT experiment

    NASA Astrophysics Data System (ADS)

    Pellegrino, C.; KM3NeT Collaboration

    2016-01-01

    Starting from 2015, the new generation underwater high energy neutrino telescope, KM3NeT, is being installed in the Mediterranean Sea. During Phase 1, 32 Detection Units (8 tower-like and 24 string-like) will be deployed in the Ionian Sea, about 100km offshore Portopalo di Capo Passero, Sicily, and 7 string-like DUs will be deployed in the MEUST site, offshore Toulon in France. During Phase 2, several hundreds of DUs will be added to the Phase 1 detector, reaching an effective detection volume of some cubic kilometres. In this contribution the Trigger and Data Acquisition System (TriDAS) of the string-based detector is described. The TriDAS is designed to scale with the detector size, allowing the read-out and the on-line trigger of data from both Phase 1 and Phase 2, whose continuous throughputs are expected to be about 10Gbps and more than 250Gbps, respectively.

  7. Sensitivity of Global Modeling Initiative CTM predictions of Antarctic ozone recovery to GCM and DAS generated meteorological fields

    SciTech Connect

    Rotman, D; Bergmann, D

    2003-12-04

    We use the Global Modeling Initiative chemistry and transport model to simulate the evolution of stratospheric ozone between 1995 and 2030, using boundary conditions consistent with the recent World Meteorological Organization ozone assessment. We compare the Antarctic ozone recovery predictions of two simulations, one driven by meteorological data from a general circulation model (GCM), the other using the output of a data assimilation system (DAS), to examine the sensitivity of Antarctic ozone recovery predictions to the characteristic dynamical differences between GCM and DAS-generated meteorological data. Although the age of air in the Antarctic lower stratosphere differs by a factor of 2 between the simulations, we find little sensitivity of the 1995-2030 Antarctic ozone recovery between 350 K and 650 K to the differing meteorological fields, particularly when the recovery is specified in mixing ratio units. Relative changes are smaller in the DAS-driven simulation compared to the GCM-driven simulation due to a surplus of Antarctic ozone in the DAS-driven simulation which is not consistent with observations. The peak ozone change between 1995 and 2030 in both simulations is {approx}20% lower than photochemical expectations, indicating that changes in ozone transport at 450 K between 1995 and 2030 constitute a small negative feedback. Total winter/spring ozone loss during the base year (1995) of both simulations and the rate of ozone loss during August and September is somewhat weaker than observed. This appears to be due to underestimates of Antarctic Cl{sub y} at the 450 K potential temperature level.

  8. Correlation between DAS-28 and neopterin as a biochemical marker of immune system activation in early rheumatoid arthritis.

    PubMed

    D'agostino, Liliana Elena; Ventimiglia, Fernando; Verna, Juan Antonio; Colina, Amelia De La; Aguirre, Yanina; Arturi, Alfredo; Capparelli, Alberto

    2013-02-01

    The objective of this study was to evaluate neopterin plasma concentrations in patients with early Rheumatoid Arthritis (RA) and correlate them with disease activity. This is a 28-month prospective study carried out on 65 individuals. There were 27 patients with early RA and 38 healthy volunteers as control group. Enzyme immunoassay was used to measure concentrations of neopterin and anti-cyclic citrullinated peptide (CCP) antibodies. Rheumatoid factor (RF) and C-reactive protein (CRP) were measured turbidimetrically, and antinuclear antibodies (ANA) were detected by immunofluorescence. Patients with early RA disease activity were divided into 4 groups according to DAS-28 criteria. Neopterin concentrations in RA patients were compared to conventional RA diagnostic serological markers. Healthy volunteers had a mean neopterin concentration of 5.63 ± 0.38 [1.36-9.93] nmol. L(- 1). A statistically significant elevation of neopterin mean concentration was found on early RA patients: mean value of 8.92 ± 0.93 [3.94-28.3] nmol. L(- 1) (p < 0.001). Pearson product moment correlation suggests a correlation between neopterin concentrations and DAS-28 (r = 0.208, p = 0.065). The analysis of the mean values grouped according with the DAS-28 criteria showed a correspondence between these means, with a Pearson correlation coefficient r = 0.979, p = 0.021. CRP concentrations also showed a similar trend. Anti-CCP antibodies and RF revealed a positive relationship with RA activity. Such a correlation was not found with ANA results. The elevation of plasma neopterin concentrations in early RA patients may indicate stimulation of immune response. Good correlation between neopterin concentrations and DAS-28 may facilitate assessing disease activity.

  9. Periodontal therapy in chronic periodontitis lowers gingival crevicular fluid interleukin-1beta and DAS28 in rheumatoid arthritis patients.

    PubMed

    Bıyıkoğlu, Başak; Buduneli, Nurcan; Aksu, Kenan; Nalbantsoy, Ayşe; Lappin, David F; Evrenosoğlu, Evren; Kinane, Denis F

    2013-10-01

    To evaluate clinical outcomes and effects of non-surgical periodontal therapy on serum, gingival crevicular fluid (GCF) interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) levels in chronic periodontitis patients with/without rheumatoid arthritis (RA), fifteen RA patients with chronic periodontitis (RA-P) and 15 systemically healthy non-RA chronic periodontitis patients (H-P) were recruited. Clinical periodontal recordings, GCF, and blood samples were obtained at baseline, 1, 3, and 6 months after periodontal treatment. GCF, serum IL-1β, TNF-α levels were analyzed by ELISA. Disease activity score 28 (DAS28) was used to assess RA clinical morbidity. Study groups were compared by Mann-Whitney U test. Wilcoxon test was used to compare the data at baseline, 1, 3, and 6 months after periodontal therapy within the same group. DAS28 decreased significantly after periodontal therapy in RA-P group (p < 0.01). Serum TNF-α concentrations of H-P group were significantly higher than those of RA-P group (p < 0.01), whereas IL-1β levels were similar. No significant change was observed in serum levels of these cytokines after periodontal therapy. GCF IL-1β amounts decreased significantly in both groups following treatment (p < 0.01). At 6-months, H-P GCF IL-1β concentrations were significantly lower than baseline. DAS28 and GCF IL-1β correlated with clinical periodontal indices (p < 0.01). Significant decreases in DAS28 and GCF IL-1β amounts after periodontal treatment suggest that periodontal therapy synergizes with systemic RA therapy to improve RA status.

  10. MiDas: automatic extraction of a common domain of discourse in sleep medicine for multi-center data integration.

    PubMed

    Sahoo, Satya S; Ogbuji, Chimezie; Luo, Lingyun; Dong, Xiao; Cui, Licong; Redline, Susan S; Zhang, Guo-Qiang

    2011-01-01

    Clinical studies often use data dictionaries with controlled sets of terms to facilitate data collection, limited interoperability and sharing at a local site. Multi-center retrospective clinical studies require that these data dictionaries, originating from individual participating centers, be harmonized in preparation for the integration of the corresponding clinical research data. Domain ontologies are often used to facilitate multi-center data integration by modeling terms from data dictionaries in a logic-based language, but interoperability among domain ontologies (using automated techniques) is an unresolved issue. Although many upper-level reference ontologies have been proposed to address this challenge, our experience in integrating multi-center sleep medicine data highlights the need for an upper level ontology that models a common set of terms at multiple-levels of abstraction, which is not covered by the existing upper-level ontologies. We introduce a methodology underpinned by a Minimal Domain of Discourse (MiDas) algorithm to automatically extract a minimal common domain of discourse (upper-domain ontology) from an existing domain ontology. Using the Multi-Modality, Multi-Resource Environment for Physiological and Clinical Research (Physio-MIMI) multi-center project in sleep medicine as a use case, we demonstrate the use of MiDas in extracting a minimal domain of discourse for sleep medicine, from Physio-MIMI's Sleep Domain Ontology (SDO). We then extend the resulting domain of discourse with terms from the data dictionary of the Sleep Heart and Health Study (SHHS) to validate MiDas. To illustrate the wider applicability of MiDas, we automatically extract the respective domains of discourse from 6 sample domain ontologies from the National Center for Biomedical Ontologies (NCBO) and the OBO Foundry.

  11. MoSST DAS: The First Working Geomagnetic Data Assimilation System

    NASA Technical Reports Server (NTRS)

    Kuang, Weijia; Wei, Zigang; Tangborn, Andrew

    2011-01-01

    The Earth possesses an internal magnetic field (geomagnetic field) generated by convection in the outer core (geodynamo). Previous efforts have been focused along two distinct paths: (1) numerical geodynamo modeling to understand the origin of the geomagnetic field, and the mechanisms of geomagnetic secular variations (SV); and (2) geomagnetic field modeling to map the spatial/temporal variations of the field from geomagnetic data, and to derive core properties, e.g. inversion of core flow near the core-mantle boundary (CMB). Geomagnetic data assimilation is a new approach emerged over the past 5 years: surface observations are assimilated with geodynamo models for better understanding of the core dynamical state, and accurately prediction of SV. In collaboration with several geomagnetic research groups, we have developed the first working geomagnetic data assimilation system, Modular, Scalable, Self-consistent, and Three-dimensional (MoSST) DAS, that includes the MoSST numerical dynamo model; 7000 years of geomagnetic field maps from several field models utilizing satellite and ground observatory data, historical magnetic records and archeo/paleo magnetic data; and an ensemble based optimal interpolation (01) assimilation algorithm. With this system, we have demonstrated clearly that the assimilated core dynamical state is substantially different from those of pure geodynamo simulations. Ensemble assimilation runs also show the convergence of the assimilated solutions inside the core, suggesting that the simulation state is pulled closer to the truth via data assimilation. The forecasts from this system are also very accurate: the 5-year forecast of the geomagnetic field agrees very well with the observations; and the 5-year secular variation forecast is more accurate than the IGRF SV forecast models in the past. Using geomagnetic records up to 2009, we have made an SV forecast for the period from 2010-2015, and is a candidate SV model for IGRF-11.

  12. A novel abundant family of retroposed elements (DAS-SINEs) in the nine-banded armadillo (Dasypus novemcinctus).

    PubMed

    Churakov, Gennady; Smit, Arian F A; Brosius, Jürgen; Schmitz, Jürgen

    2005-04-01

    About half of the mammalian genome is composed of retroposons. Long interspersed elements (LINEs) and short interspersed elements (SINEs) are the most abundant repetitive elements and account for about 21% and 13% of the human genome, respectively. SINEs have been detected in all major mammalian lineages, except for the South American order Xenarthra, also termed Edentata (armadillos, anteaters, and sloths). Investigating this order, we discovered a novel high-copy-number family of tRNA derived SINEs in the nine-banded armadillo Dasypus novemcinctus, a species that successfully crossed the Central American land bridge to North America in the Pliocene. A specific computer algorithm was developed, and we detected and extracted 687 specific SINEs from databases. Termed DAS-SINEs, we further divided them into six distinct subfamilies. We extracted tRNA(Ala)-derived monomers, two types of dimers, and three subfamilies of chimeric fusion products of a tRNA(Ala) domain and an approximately 180-nt sequence of thus far unidentified origin. Comparisons of secondary structures of the DAS-SINEs' tRNA domains suggest selective pressure to maintain a tRNA-like D-arm structure in the respective founder RNAs, as shown by compensatory mutations. By analysis of subfamily-specific genetic variability, comparison of the proportion of direct repeats, and analysis of self-integrations as well as key events of dimerization and deletions or insertions, we were able to delineate the evolutionary history of the DAS-SINE subfamilies.

  13. Predictors of European League Against Rheumatism (EULAR) good response, DAS-28 remission and sustained responses to TNF-inhibitors in rheumatoid arthritis: a prospective study in refractory disease.

    PubMed

    Mohammed, Reem Hamdy A; Farahat, Faisal; Kewan, Hanady H; Bukhari, Mohammed A

    2015-01-01

    The aim of this study was to survey factors related to EULAR good response, the DAS-28 definition of remission, ACR 50 response, sustained response to tumor necrosis factor inhibitors (TNF-I) therapy in biologic naïve patients with refractory rheumatoid arthritis. This was a single center observational clinical prospective 2 years' study, EULAR response criteria, DAS 28, HAQ and radiographic changes were recorded. Eighty patients included (64 females and 16 males, mean age was 48.4 + -17.9 years, mean disease duration 7.3 + -5.9 years). At 6 months 70% achieved EULAR good response, 51.8% achieved DAS-28 remission. Good response/sustained responses inversely correlated with baseline DAS-28 and radiographic erosions P <0.05. EULAR good response/remission by 6 months, sustained response at 2 years positively correlated with the decline in RF titers (r = 0.33, P < 0.05 & r = 0.30, P < 0.03 respectively), negatively correlated with the baseline HAQ. Regression analysis identified higher serum hemoglobin concentration, lower baseline HAQ scores, and the absence of radiographic erosions as significant predictors of good as well as sustained responses after adjustment for potential covariates. Methotrexate was associated with favorable responses and remission at 6 months (ORs = 1.13, 1.30 respectively). The study concluded that a lower baseline DAS-28 and HAQ scores, the lack of radiographic erosions favored EULAR good response and were significant predictors of sustained response to TNF-I.

  14. Properties of Noise Cross Correlation Functions Obtained from a Distributed Acoustic Sensing (DAS) Array at Garner Valley, California

    NASA Astrophysics Data System (ADS)

    Zeng, X.; Lancelle, C.; Thurber, C. H.; Fratta, D.; Wang, H. F.; Chalari, A.; Clarke, A.

    2015-12-01

    The field test of Distributed Acoustic Sensing (DAS) conducted at Garner Valley, California on September 11-12, 2013 provided a continuous overnight record of ambient noise. The DAS array recorded ground motions every one meter of optical cable that was arranged approximately in the shape of a rectangle with dimensions of 160 m by 80 m. The long dimension of the array was adjacent to a state highway. Three hours of record were used to compute noise cross-correlation functions (NCFs) in one-minute windows. The trace from each sensor channel was pre-processed by downsampling to 200 Hz, followed by normalization in the time-domain and bandpass filtering between 2 and 20 Hz (Bensen et al., 2007). The one-minute NCFs were then stacked using the time-frequency domain phase-weighted stacking method (Schimmel & Gallart, 2007). The NCFs between channels were asymmetrical reflecting the direction of traffic noise. The group velocities were found using the frequency-time analysis method. The energy was concentrated between 5 and 15 Hz, which falls into the typical traffic noise frequency band. The resulting velocities were between 100 and 300 m/s for frequencies between 10 and 20 Hz, which are in the same range as described in the results for surface-wave dispersion obtained using an active source for the same site (Lancelle et al., 2015). The group velocity starts to decrease for frequencies greater than ~10 Hz, which was expected on the basis of a previous shear-wave velocity model (Steidl et al., 1996). Then, the phase velocity was calculated using the multichannel analysis of surface wave technique (MASW - Park et al., 1999) with 114 NCFs spaced one meter apart. The resulting dispersion curve between 5 and 15 Hz gave phase velocities that ranged from approximately 170 m/s at 15 Hz to 250 m/s at 5 Hz. These results are consistent with other results of active-source DAS and seismometer records obtained at the Garner Valley site (e.g., Stokoe et al. 2004). This analysis is

  15. Antimicrobial activity of plants used as medicinals on an indigenous reserve in Rio das Cobras, Paraná, Brazil.

    PubMed

    Moura-Costa, Gislaine F; Nocchi, Samara R; Ceole, Ligia F; de Mello, João Carlos P; Nakamura, Celso Vataru; Dias Filho, Benedito Prado; Temponi, Livia G; Ueda-Nakamura, Tania

    2012-09-28

    A considerable percentage of global biodiversity is located in Brazil, a country that also has rich cultural and ethnic diversity. In the community of Rio das Cobras, Paraná, plants are still widely used in the health care not only by indigenous people but also by the non-indigenous population that inhabits the region. The investigation of the efficacy and safety of these plants in the treatment of infectious diseases provides insights for future studies of these species allowing the appropriated use by the indigenous people, since few or none study has been conducted so far. Evaluate the antimicrobial activity and cytotoxicity of some plants used as medicinal on an indigenous reserve in Rio das Cobras, Paraná, Brazil. The aqueous extracts were obtained by decoction and the 50% and 70% hydroalcoholic extracts by turbo extraction. The extracts were tested against strains of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Candida albicans, Candida parapsilosis, Candida tropicalis, Leishmania amazonensis, Poliovirus and HSV-1. Cytotoxicity assay using VERO cells were also performed. None of the extracts had a selectivity index (SI)>1 for any of the tested bacteria. Only Campomanesia eugenioides and Schinus terebinthifolius had an SI>1.0 for all of the tested Candida species. The best anti-Leishmania activity was obtained with Zanthoxylum rhoifolium and Schinus terebinthifolius. Extracts of Cordia americana were the most effective against herpes simplex virus type 1. Zanthoxylum rhoifolium was the most effective against Poliovirus, and Ocimum gratissimum was effective against both Poliovirus and Herpes Simplex virus. Among the plants investigated in the present study, Zanthoxylum rhoifolium had the fewest cytotoxic effect. The plants investigated in the present study exhibited potential for future pharmacological uses, but additional studies, especially with regard to in vivo toxicity, must be conducted. The results of this

  16. Insect-Protected Event DAS-81419-2 Soybean (Glycine max L.) Grown in the United States and Brazil Is Compositionally Equivalent to Nontransgenic Soybean

    PubMed Central

    2015-01-01

    The transgenic soybean event DAS-81419-2 contains genes that encode the Cry1F, Cry1Ac, and PAT proteins. Cry1F and Cry1Ac provide protection against key lepidopteran insect pests, while PAT confers tolerance to the herbicide glufosinate. To satisfy regulatory requirements for the safety evaluation of transgenic crops, studies were conducted in the United States and Brazil to evaluate the nutrient and antinutrient composition of event DAS-81419-2 soybean. On the basis of the results of these studies, event DAS-81419-2 soybean is compositionally equivalent to nontransgenic soybean. This conclusion concurs with numerous other published studies in soybean and other crops where compositional equivalence between the transgenic crop and its nontransgenic comparator has been demonstrated. PMID:25641393

  17. Insect-protected event DAS-81419-2 soybean (Glycine max L.) grown in the United States and Brazil is compositionally equivalent to nontransgenic soybean.

    PubMed

    Fast, Brandon J; Schafer, Ariane C; Johnson, Tempest Y; Potts, Brian L; Herman, Rod A

    2015-02-25

    The transgenic soybean event DAS-81419-2 contains genes that encode the Cry1F, Cry1Ac, and PAT proteins. Cry1F and Cry1Ac provide protection against key lepidopteran insect pests, while PAT confers tolerance to the herbicide glufosinate. To satisfy regulatory requirements for the safety evaluation of transgenic crops, studies were conducted in the United States and Brazil to evaluate the nutrient and antinutrient composition of event DAS-81419-2 soybean. On the basis of the results of these studies, event DAS-81419-2 soybean is compositionally equivalent to nontransgenic soybean. This conclusion concurs with numerous other published studies in soybean and other crops where compositional equivalence between the transgenic crop and its nontransgenic comparator has been demonstrated.

  18. Priming index of the Spanish word fragments from the Dasí, Soler, and Ruiz (2004) database.

    PubMed

    Dasí, Carmen; Soler, María José; Ruiz, Juan Carlos

    2007-08-01

    Word-fragment completion is a frequently used test in implicit memory research. A database of 196 Spanish fragments was recently published (Dasí, Soler, & Ruiz, 2004) in which the fragments were described for indices, such as difficulty, familiarity, frequency, number of meanings, and so on (www.psychonomic.org/archive). In this work, a new index, the priming index, is described for the same 196 fragments. This index is calculated for each fragment by subtracting the difficulty index (the proportion of correct completion when the fragment is not studied) from the proportion of correct completion when the fragment is studied, and it means the capacity of an item to be primed. In order to determine whether the new index performs well, we have replicated some important experimental effects, such as priming, frequency, and difficulty. We consider that this index can help researchers to better select stimuli for fragment-completion tasks.

  19. Das Märchen vom Zauberer im weißen Kittel: Mythen um berühmte Experimente und Experimentatoren

    NASA Astrophysics Data System (ADS)

    Hentschel, Klaus

    2003-09-01

    Um berühmte Experimentatoren und Experimente ranken sich ebenso Mythen wie um geniale Theoretiker. Sie sind in populärwissenschaftlichen Büchern, Lehrbüchern und sogar in wissenschaftshistorischen Texten verbreitet. Die durch die Aufklärung etablierte Kultur des eleganten Schauexperiments vermittelt ein schiefes Bild vom mühsamen Weg vieler Experimentatoren zum dargestellten Ergebnis. Auch der Mythos des einsamen, genialen Experimentators ohne Helfer widerspricht dem historischen Befund. Gleiches gilt für das experimentum crucis, das eine Theorie als entscheidendes Experiment belegen soll. Die historische Forschung zeigt, dass es eine lange, eigenständige Tradition der experimentellen und instrumentellen Arbeit gibt.

  20. Development of a surface-wave imaging system for geotechnical applications based on distributed acoustic sensing (DAS) and ambient noise interferometry

    NASA Astrophysics Data System (ADS)

    Ajo Franklin, J. B.; Daley, T. M.; Freifeld, B. M.; Tang, D. G.; Zhang, R.; Wagner, A. M.; Dou, S.; Lindsey, N.; Bjella, K.; Pevzner, R.

    2014-12-01

    Distributed fiber-optic sensing methods have been used since the 1980's for continuous monitoring of near-surface soil properties, typically exploiting Raman scattering to measure temperature (DTS) or stimulated Brillouin scattering to measure strain (DSS). Recent advances in high speed measurement of Rayleigh scattering has enabled distributed recording of seismic waves over long sections of fiber; this approach, referred to as distributed acoustic sensing (DAS) has the potential to allow nearly continuous monitoring of near-surface mechanical properties, a crucial target for geotechnical management of infrastructure dependent on soil strength. We present initial results from our effort to build a real-time soil property monitoring system based on DAS; our approach employs seismic interferometry and dispersion analysis of ambient noise generated by infrastructure to provide a continuously updated model of shear modulus. Our preliminary results include an in-depth investigation of DAS fiber response in the context of active sources; this component of our study verifies classical models for the azimuthal response of straight fibers to propagating surface waves. We also explore the "noisescape" of linear infrastructure and show a usable seismic signal band of 8-40 hz at a series of sites, primarily consisting of Rayleigh waves. Finally, we present preliminary results from a DAS monitoring array installed at the Richmond Field Station near a heavily used road and compare interferometric processing of the acquired data to that generated by surface deployment of geophones.

  1. Inhibition of Primary Clinical Isolates of Human Parainfluenza Virus by DAS181 in Cell Culture and in a Cotton Rat Model

    PubMed Central

    Jones, B. G.; Hayden, R.T.; Hurwitz, J. L.

    2013-01-01

    DAS181 is a novel drug in development for the treatment of influenza as well as human parainfluenza viruses (hPIV). Previous studies demonstrated that DAS181 inhibited laboratory strains of hPIV, but no tests were conducted with primary clinical isolates of hPIV. To fill this gap, we studied six primary isolates including hPIV-2 and hPIV-3. First tests showed that the amplification of all viruses in vitro was reproducibly inhibited with DAS181 drug concentrations ranging between 0.1 and 1 nM. An hPIV-3 primary clinical isolate was then tested in a cotton rat model for sensitivity to 0.3-1 mg/kg drug treatments. Results showed that virus amplification in the lower respiratory tract was significantly and reproducibly inhibited by drug. Together, experiments demonstrated that DAS181 inhibited primary clinical isolates of hPIV in vitro and in vivo at doses similar to those previously described for inhibition of laboratory hPIV and influenza virus isolates. PMID:24076357

  2. Novas determinações dos parâmetros atmosféricos das estrelas anãs brancas DA

    NASA Astrophysics Data System (ADS)

    Giovannini, O.; Costa, A. F. M.; Kepler, S. O.

    2003-08-01

    Nós temos selecionado uma amostra de estrelas anãs brancas DA (atmosfera de hidrogênio) a partir dos índices de Strömgren cujos valores estão próximos a região de instabilidade das estrelas anãs brancas DA variáveis, as chamadas estrelas DAV ou ZZ Ceti. O objetivo é determinar os parâmetros fundamentais (temperatura efetiva, Teff, aceleração da gravidade, log g, e massa) destas estrelas para verificar quais os parâmetros estelares estão envolvidos com o mecanismo de pulsação das estrelas DAV. Nós obtemos, até agora, mais de 120 espectros óticos de estrelas DA. Entre as estrelas selecionadas há 20 estrelas variáveis (DAV). Assim, podemos verificar se existem ou não estrelas não variáveis dentro da faixa de instabilidade das estrelas ZZ Ceti. Neste trabalho nós apresentamos a determinação dos parâmetros atmosféricos (temperatura efetiva, Teff, e aceleração da gravidade, log g) das estrelas anãs brancas DA usando os novos modelos de atmosfera ML2/a = 0.6. Estes modelos têm sido utilizados recentemente por fornecerem uma excelente consistência interna na determinação das temperaturas nas regiões do ultra-violeta e ótico. Os parâmetros atmosféricos são determinados espectroscopicamente através da comparação do fluxo de energia das linhas de Balmer (Hb à H9) entre os espectros observados e sintéticos (gerados pelos modelos de atmosfera). As temperaturas obtidas com os novos modelos são, em geral, menores (~ 1000 K menos) que as temperaturas determinadas anteriormente, com modelos ML1. Os valores de log g não mudaram significativamente (menos de 10%). A faixa de instabilidade das DAVs está entre 11000 e 13000 K, consistente com dados de outros autores.

  3. Three genes encoding citrate synthases in Saccharopolyspora erythraea are regulated by the global nutrient-sensing regulators GlnR, DasR, and CRP.

    PubMed

    Liao, Cheng-Heng; Yao, Li-Li; Ye, Bang-Ce

    2014-10-08

    Saccharopolyspora erythraea has three citrate synthases encoded by gltA-2, citA, and citA4. Here, we characterized and identified the expression and regulatory properties of these synthases. Three pleiotropic global regulatory proteins of S. erythraea - CRP, GlnR, and DasR - are involved in carbon metabolism, nitrogen metabolism, and amino-sugar (chitin and GlcNAc) metabolism. Using electrophoretic mobility shift assays (EMSAs), we identified these regulators as proteins that bind directly to the promoter regions of all citrate synthase genes (gltA-2, citA, and citA4). Footprinting assays indicated the exact protect sequences of CRP, GlnR, and DasR on the promoter region of gltA-2, revealing binding competition between GlnR and DasR. Moreover, by comparing the transcription levels of citrate synthase genes between parental and glnR mutant or dasR mutant strains, or by comparing the transcription response of citrate synthases under various nutrient conditions, we found that GlnR and DasR negatively regulated citA and citA4 transcription but had no regulatory effects on the gltA-2 gene. Although no CRP mutant was available, the results indicated that CRP was a cAMP-binding receptor affecting gltA-2 transcription when the intracellular cAMP concentration increased. Thus, an overall model of CS regulation by C and/or N metabolism regulators and cAMP receptor protein was proposed.

  4. Simulation of the single-vibronic-level emission spectra of HAsO and DAsO

    NASA Astrophysics Data System (ADS)

    Mok, Daniel K. W.; Lee, Edmond P. F.; Dyke, John M.

    2016-05-01

    The single-vibronic-level (SVL) emission spectra of HAsO and DAsO have been simulated by electronic structure/Franck-Condon factor calculations to confirm the spectral molecular carrier and to investigate the electronic states involved. Various multi-reference (MR) methods, namely, NEVPT2 (n-electron valence state second order perturbation theory), RSPT2-F12 (explicitly correlated Rayleigh-Schrodinger second order perturbation theory), and MRCI-F12 (explicitly correlated multi-reference configuration interaction) were employed to compute the geometries and relative electronic energies for the X ˜ 1 A ' and A ˜ 1 A ″ states of HAsO. These are the highest level calculations on these states yet reported. The MRCI-F12 method gives computed T0 (adiabatic transition energy including zero-point energy correction) values, which agree well with the available experimental T0 value much better than previously computed values and values computed with other MR methods in this work. In addition, the potential energy surfaces of the X ˜ 1 A ' and A ˜ 1 A ″ states of HAsO were computed using the MRCI-F12 method. Franck-Condon factors between the two states, which include anharmonicity and Duschinsky rotation, were then computed and used to simulate the recently reported SVL emission spectra of HAsO and DAsO [R. Grimminger and D. J. Clouthier, J. Chem. Phys. 135, 184308 (2011)]. Our simulated SVL emission spectra confirm the assignments of the molecular carrier, the electronic states involved, and the vibrational structures observed in the SVL emission spectra but suggest a loss of intensity in the reported experimental spectra at the low emission energy region almost certainly due to a loss of responsivity near the cutoff region (˜800 nm) of the detector used. Computed and experimentally derived re (equilibrium) and/or r0 {the (0,0,0) vibrational level} geometries of the two states of HAsO are discussed.

  5. Simulation of the single-vibronic-level emission spectra of HAsO and DAsO.

    PubMed

    Mok, Daniel K W; Lee, Edmond P F; Dyke, John M

    2016-05-14

    The single-vibronic-level (SVL) emission spectra of HAsO and DAsO have been simulated by electronic structure/Franck-Condon factor calculations to confirm the spectral molecular carrier and to investigate the electronic states involved. Various multi-reference (MR) methods, namely, NEVPT2 (n-electron valence state second order perturbation theory), RSPT2-F12 (explicitly correlated Rayleigh-Schrodinger second order perturbation theory), and MRCI-F12 (explicitly correlated multi-reference configuration interaction) were employed to compute the geometries and relative electronic energies for the X̃(1)A(') and Ã(1)A(″) states of HAsO. These are the highest level calculations on these states yet reported. The MRCI-F12 method gives computed T0 (adiabatic transition energy including zero-point energy correction) values, which agree well with the available experimental T0 value much better than previously computed values and values computed with other MR methods in this work. In addition, the potential energy surfaces of the X̃(1)A(') and Ã(1)A(″) states of HAsO were computed using the MRCI-F12 method. Franck-Condon factors between the two states, which include anharmonicity and Duschinsky rotation, were then computed and used to simulate the recently reported SVL emission spectra of HAsO and DAsO [R. Grimminger and D. J. Clouthier, J. Chem. Phys. 135, 184308 (2011)]. Our simulated SVL emission spectra confirm the assignments of the molecular carrier, the electronic states involved, and the vibrational structures observed in the SVL emission spectra but suggest a loss of intensity in the reported experimental spectra at the low emission energy region almost certainly due to a loss of responsivity near the cutoff region (∼800 nm) of the detector used. Computed and experimentally derived re (equilibrium) and/or r0 {the (0,0,0) vibrational level} geometries of the two states of HAsO are discussed.

  6. Entomological fauna from Reserva Biológica do Atol das Rocas, RN, Brazil: I. Morphospecies composition.

    PubMed

    Almeida; Marchon-Silva; Ribeiro; Serpa-Filho; Almeida; Costa

    2000-05-01

    Atol das Rocas, the unique atoll in the South-western Atlantic, is located 144 nautical miles (266 Km) northeast from the city of Natal, NE Brazil and 80 nautical miles from Arquipélago de Fernando de Noronha, with geographic co-ordinates 3 masculine51'S and 33 masculine49"W. It's of volcanic origin and coralline formation. The reef is ellipsoid, its largest axis (E-W) is approximately 3.7 km long, and the shortest (N-S) is 2.5 km. Inside the lagoon, there are two islands: the Ilha do Farol and Ilha do Cemitério, which comprehend 7.2 Km2 of emerged area. The Atol das Rocas lodges 143,000 birds, mainly by Sula dactilatra, S. leucogaster, Anous stolidus, A. minuta and Sterna fuscata. Due to their remote location, the islands remain largely undisturbed by the human activities. Aiming to a first characterization of the entomological diversity and the general trophic niches of atoll's entomofauna, three collects were made (1994, 1995 and 1996) utilizing several methods for a wide sample. One thousand six hundred and six insect specimens were collected belonging to eight orders: 1. Coleoptera - 333 individuals of Dermestidae (Dermestes cadaverinus); Tenebrionidae (Phaleria testacea and morphospecies) and Curculionidae (one morphospecies); 2. Dermaptera - 50 individuals of Carcinophoridae (Anisolabis maritima); 3. Diptera - 281 individuals of Ephydridae (Scatella sp. and Hecamede sp.) and Hippoboscidae (one morphospecies); 4. Hymenoptera - 45 individuals of Formicidae (Brachymyrmex sp.); 5. Lepidoptera - 111 individuals of Microlepidoptera (one morphospecies); 6. Mallophaga - 18 individuals in birds (two morphospecies); 7. Orthoptera - 237 individuals of Acrididae (Schistocerca cancellata), Tridactylidae (one morphospecies) and Blattidae (three morphospecies); 8. Thysanoptera -531 individuals (one morphospecies). Also were collected 112 individuals of Arachnida. The taxa of the Order Araneae were represented by the families: 1. Miturgidae (Cheiracanthium inclusum); 2

  7. Evaluation of corn grain with the genetically modified input trait DAS-59122-7 fed to growing-finishing pigs.

    PubMed

    Stein, H H; Rice, D W; Smith, B L; Hinds, M A; Sauber, T E; Pedersen, C; Wulf, D M; Peters, D N

    2009-04-01

    A growth performance experiment was conducted to assess the feeding value of a double-stacked transgenic corn grain for growing-finishing pigs. The genetically modified corn grain contained event DAS-59122-7, which expresses the Cry34/35Ab1 binary insecticidal protein for the control of corn rootworm. This modified transgenic grain is resistant to western corn rootworm and is also tolerant to herbicides containing the active ingredient glufosinate-ammonium. The modified grain (59122), a nontransgenic near-isoline grain (control corn), and a commercial corn (Pioneer brand hybrid 35P12) were grown in a 2005 production trial in individually isolated plots that were located 201 m apart. A total of 108 pigs were allotted to corn-soybean meal diets containing 1 of the 3 grains as the sole source of corn. There were 3 pigs per pen and 12 replicate pens per treatment. Pigs were fed grower diets from 37 to 60 kg, early finisher diets from 60 to 90 kg, and late finisher diets from 90 to 127 kg. Within each phase, data for ADG, ADFI, and G:F were calculated. At the conclusion of the experiment, pigs were slaughtered and data for carcass quality were collected. Differences between 59122 and the control corn were evaluated, with statistical significance at P<0.05. No differences in ADG, ADFI, or G:F between pigs fed the control corn and pigs fed the modified corn were observed during the grower, early finisher, or late finisher phases. For the entire experimental period, no difference between pigs fed the control and the 59122 corn were observed for final BW (128.9 vs. 127.1 kg), ADG (1.02 vs. 1.00 kg), ADFI (2.88 vs. 2.80 kg), or G:F (0.356 vs. 0.345 kg/kg). Likewise, no differences in dressing percentage (76.48 vs. 76.30%), LM area (49.8 vs. 50.4 cm(2)), 10th-rib back fat (2.20 vs. 2.12 cm), and carcass lean content (52.9 vs. 53.4%) were observed between pigs fed the control and the 59122 corn grain. It was concluded that the nutritional value of the modified transgenic corn

  8. Wood anatomy of Mollinedia glabra (Spreng.) Perkins (Monimiaceae) in two Restinga Vegetation Formations at Rio das Ostras, RJ, Brazil.

    PubMed

    Novaes, Fernanda da S; Callado, Cátia H; Pereira-Moura, Maria Verônica L; Lima, Helena R P

    2010-12-01

    This paper aimed to characterize the anatomical structure of the wood of specimens of Mollinedia glabra (Spreng.) Perkins growing in two contiguous formations of restinga vegetation at Praia Virgem, in the municipality of Rio das Ostras, RJ. Both the Open Palmae (OPS) and the Sandy Strip Closed Shrub (SSCS) formations are found in coastal regions that receive between 1,100 and 1,300 mm of rainfall per year. Sapwood samples were collected in both formations. Typical anatomical features for this species include: solitary vessels, radial multiples or clusters elements, that are circular to angular in outline, 5-15 barred scalariform perforation plates, wood parenchyma scanty, septate fiber-tracheids, and wide multiseriate rays with prismatic crystals. Statistical analyses indicated a significant increase in the frequency of vessel elements and an increase in fiber-tracheid diameters in OPS individuals. These characteristics are considered structural adaptations to increased water needs caused by a greater exposure to sunlight. Continuous pruning may be responsible for the tyloses observed in OPS plants. The greater lengths and higher frequencies of the rays in SSCS trees may be due to the greater diameters of their branches. Our results suggest that M. glabra develops structural adaptations to the restinga micro-environmental variations during its development.

  9. Von neuen Geschäftsideen zur gelebten Digitalisierung in Utility 4.0 - das Integrierte Geschäftsmodell

    NASA Astrophysics Data System (ADS)

    Doleski, Oliver D.

    Die Energiewirtschaft benötigt neue, digitale Geschäftsmodelle. Gegenwärtig folgt auf Liberalisierung und Energiewende die nächste Stufe einer weitreichenden Bereinigung des Versorgungsmarktes. Digitalisierung und Dezentralisierung sind heute in aller Munde und verlangen nach neuen Produkten und Dienstleistungen. Dabei wirken die immensen Herausforderungen einer digitalen Energiewelt wie Beschleuniger für die Transformation im Versorgungssektor und tragen damit zur breiten Etablierung von Utilities 4.0 bei. Dieser Entwicklungsprozess vollzieht sich mithilfe unterschiedlicher Methoden zur Realisierung neuer Geschäftsideen. Allerdings greifen die gängigen Konzepte zur Entwicklung von Geschäftsmodellen gerade im Hinblick auf die Berücksichtigung komplexer, unbeständiger Rahmenbedingungen und spezifischer Anforderungen der digitalen Energiewelt mitunter zu kurz. Vor diesem Hintergrund wird das auf dem ganzheitlichen St. Galler Management-Konzept beruhende Integrierte Geschäftsmodell iOcTen als geeignetes Instrumentarium zur Geschäftsmodellentwicklung vorgestellt. Neben der Modellbeschreibung unterstützt ein intuitiv verständlicher Leitfaden den Praktiker bei der Transformation vom klassischen Versorgungsunternehmen zum digitalen Energiedienstleistungsunternehmen.

  10. Das Lektin aus der Erbse Pisum sativum : Bindungsstudien, Monomer-Dimer-Gleichgewicht und Rückfaltung aus Fragmenten

    NASA Astrophysics Data System (ADS)

    Küster, Frank

    2002-11-01

    Das Lektin aus Pisum sativum, der Gartenerbse, ist Teil der Familie der Leguminosenlektine. Diese Proteine haben untereinander eine hohe Sequenzhomologie, und die Struktur ihrer Monomere, ein all-ß-Motiv, ist hoch konserviert. Dagegen gibt es innerhalb der Familie eine große Vielfalt an unterschiedlichen Quartärstrukturen, die Gegenstand kristallographischer und theoretischer Arbeiten waren. Das Erbsenlektin ist ein dimeres Leguminosenlektin mit einer Besonderheit in seiner Struktur: Nach der Faltung in der Zelle wird aus einem Loop eine kurze Aminosäuresequenz herausgeschnitten, so dass sich in jeder Untereinheit zwei unabhängige Polypeptidketten befinden. Beide Ketten sind aber stark miteinander verschränkt und bilden eine gemeinsame strukturelle Domäne. Wie alle Lektine bindet Erbsenlektin komplexe Oligosaccharide, doch sind seine physiologische Rolle und der natürliche Ligand unbekannt. In dieser Arbeit wurden Versuche zur Entwicklung eines Funktionstests für Erbsenlektin durchgeführt und seine Faltung, Stabilität und Monomer-Dimer-Gleichgewicht charakterisiert. Um die spezifische Rolle der Prozessierung für Stabilität und Faltung zu untersuchen, wurde ein unprozessiertes Konstrukt in E. coli exprimiert und mit der prozessierten Form verglichen. Beide Proteine zeigen die gleiche kinetische Stabilität gegenüber chemischer Denaturierung. Sie denaturieren extrem langsam, weil nur die isolierten Untereinheiten entfalten können und das Monomer-Dimer-Gleichgewicht bei mittleren Konzentrationen an Denaturierungsmittel auf der Seite der Dimere liegt. Durch die extrem langsame Entfaltung zeigen beide Proteine eine apparente Hysterese im Gleichgewichtsübergang, und es ist nicht möglich, die thermodynamische Stabilität zu bestimmen. Die Stabilität und die Geschwindigkeit der Assoziation und Dissoziation in die prozessierten bzw. nichtprozessierten Untereinheiten sind für beide Proteine gleich. Darüber hinaus konnte gezeigt werden, dass auch unter

  11. Free convection in a parallelogrammic porous cavity filled with a nanofluid using Tiwari and Das' nanofluid model.

    PubMed

    Ghalambaz, Mohammad; Sheremet, Mikhail A; Pop, Ioan

    2015-01-01

    The free convection heat transfer of Cu-water nanofluids in a parallelogrammic enclosure filled with porous media is numerically analyzed. The bottom and top of the enclosure are insulated while the sidewalls are subject to limited temperature difference. The Darcy flow and the Tiwari and Das' nanofluid models are considered. The governing dimensionless partial differential equations are numerically solved using a finite difference code. The results are reported for isotherms and streamlines as well as Nusselt number as a function of the volume fraction of nanoparticles, porosity, types of the porous matrix, inclination angle, aspect ratio and different Rayleigh numbers. It is found that the presence of the nanoparticles inside the enclosure deteriorates the heat transfer rate, which is caused due to the increase of dynamic viscosity by the presence of nanoparticles. Therefore, in applications in which the nanofluids are used for their advantages, such as enhanced dielectric properties or antibacterial properties, more caution for the heat transfer design of the enclosure is necessary.

  12. Nutrient budgets (C, N and P) and trophic dynamics of a Brazilian tropical estuary: Barra das Jangadas.

    PubMed

    Noriega, Carlos E D; Araujo, Moacyr

    2011-06-01

    This paper focuses on the nutrient dynamics of a tropical estuary on the northeastern Brazilian coast, studied using the LOICZ biogeochemical budgeting protocol. We describe the methodology and assumptions underlying this model. Input data (monthly for rainfall, evaporation, river discharge, and concentrations of salt, phosphorus and nitrogen) were obtained during field campaigns in the Barra das Jangadas Estuary (BJE) over a 5 years period (1999 to 2003). Mass balance results indicate large inputs of nutrients to the system. The model shows that the seasonal variation of the Net Ecosystem Metabolism (NEM) indicates that the system passes from a stage of organic matter liquid production and mineralization during the dry season (-0.5 mmoles C m(-2) d(-1)) to liquid mineralization during the rainy season (-19 mmoles C m(-2) d(-1)). We suggest that the system varies slightly between autotrophy and heterotrophy during the year due to the rainfall regime, human activities in the basin (density population and sugarcane plantations), and associated DIP riverine loads. High per capita loads of N and P indicate a high population density and high runoff. The application of flux balance modeling was useful to understand the nutrient dynamics of this typical small tropical estuary.

  13. Stacking transgenic event DAS-Ø15Ø7-1 alters maize composition less than traditional breeding.

    PubMed

    Herman, Rod A; Fast, Brandon J; Scherer, Peter N; Brune, Alyssa M; de Cerqueira, Denise T; Schafer, Barry W; Ekmay, Ricardo D; Harrigan, George G; Bradfisch, Greg A

    2017-10-01

    The impact of crossing ('stacking') genetically modified (GM) events on maize-grain biochemical composition was compared with the impact of generating nonGM hybrids. The compositional similarity of seven GM stacks containing event DAS-Ø15Ø7-1, and their matched nonGM near-isogenic hybrids (iso-hybrids) was compared with the compositional similarity of concurrently grown nonGM hybrids and these same iso-hybrids. Scatter plots were used to visualize comparisons among hybrids and a coefficient of identity (per cent of variation explained by line of identity) was calculated to quantify the relationships within analyte profiles. The composition of GM breeding stacks was more similar to the composition of iso-hybrids than was the composition of nonGM hybrids. NonGM breeding more strongly influenced crop composition than did transgenesis or stacking of GM events. These findings call into question the value of uniquely requiring composition studies for GM crops, especially for breeding stacks composed of GM events previously found to be compositionally normal. © 2017 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology and The Association of Applied Biologists and John Wiley & Sons Ltd.

  14. Common Data Acquisition Systems (DAS) Software Development for Rocket Propulsion Test (RPT) Test Facilities - A General Overview

    NASA Technical Reports Server (NTRS)

    Hebert, Phillip W., Sr.; Hughes, Mark S.; Davis, Dawn M.; Turowski, Mark P.; Holladay, Wendy T.; Marshall, PeggL.; Duncan, Michael E.; Morris, Jon A.; Franzl, Richard W.

    2012-01-01

    The advent of the commercial space launch industry and NASA's more recent resumption of operation of Stennis Space Center's large test facilities after thirty years of contractor control resulted in a need for a non-proprietary data acquisition system (DAS) software to support government and commercial testing. The software is designed for modularity and adaptability to minimize the software development effort for current and future data systems. An additional benefit of the software's architecture is its ability to easily migrate to other testing facilities thus providing future commonality across Stennis. Adapting the software to other Rocket Propulsion Test (RPT) Centers such as MSFC, White Sands, and Plumbrook Station would provide additional commonality and help reduce testing costs for NASA. Ultimately, the software provides the government with unlimited rights and guarantees privacy of data to commercial entities. The project engaged all RPT Centers and NASA's Independent Verification & Validation facility to enhance product quality. The design consists of a translation layer which provides the transparency of the software application layers to underlying hardware regardless of test facility location and a flexible and easily accessible database. This presentation addresses system technical design, issues encountered, and the status of Stennis' development and deployment.

  15. Acute postsurgical suppurative parotitis: current prevalence at Hospital das Clínicas, São Paulo University Medical School.

    PubMed

    Belczak, Sergio Quilici; Cleva, Roberto D E; Utiyama, Edivaldo M; Cecconello, Ivan; Rasslan, Samir; Parreira, José Gustavo

    2008-01-01

    Postsurgical acute suppurative parotitis is a bacterial gland infection that occurs from a few days up to some weeks after abdominal surgical procedures. In this study, the authors analyze the prevalence of this complication in Hospital das Clínicas/São Paulo University Medical School by prospectively reviewing the charts of patients who underwent surgeries performed by the gastroenterological and general surgery staff from 1980 to 2005. Diagnosis of parotitis or sialoadenitis was analyzed. Sialolithiasis and chronic parotitis previous to hospitalization were exclusion criteria. In a total of 100,679 surgeries, 256 patients were diagnosed with parotitis or sialoadenitis. Nevertheless, only three cases of acute postsurgical suppurative parotitis associated with the surgery were identified giving an incidence of 0.0028%. All patients presented with risk factors such as malnutrition, immunosuppression, prolonged immobilization and dehydration. In the past, acute postsurgical suppurative parotitis was a relatively common complication after major abdominal surgeries. Its incidence decreased as a consequence of the improvement of perioperative antibiotic therapy and postoperative support. In spite of the current low incidence, we believe it is important to identify risks and diagnose as quick as possible, in order to introduce prompt and appropriate therapeutic measures and avoid potentially fatal complications with the evolution of the disease.

  16. Código para imageamento indireto de estrelas em sistemas binarios: simulação de variações elipsoidais e do perfil das linhas

    NASA Astrophysics Data System (ADS)

    Souza, T. R.; Baptista, R.

    2003-08-01

    As estrelas secundárias em variáveis cataclí smicas (VCs) e binárias-x de baixa massa (BXBMs) são cruciais para o entendimento da origem, evolução e comportamento destas binárias interagentes. Elas são estrelas magneticamente ativas submetidas a condições ambientais extremas [e.g., estão muito próximas de uma fonte quente e irradiante; têm rotação extremamente rápida e forma distorcida; estão perdendo massa a taxas de 10-8-10-10 M¤/ano] que contribuem para que suas propriedades sejam distintas das de estrelas de mesma massa na seqüência principal. Por outro lado, o padrão de irradiação na face da secundária fornece informação sobre a geometria das estruturas de acréscimo em torno da estrela primária. Assim, a obtenção de imagens da superfície destas estrelas é de grande interesse astrofísico. A Tomografia Roche usa as variações no perfil das linhas de emissão/absorção da estrela secundária em função da fase orbital para mapear a distribuição de brilho em sua superfície. Neste trabalho apresentamos os resultados iniciais do desenvolvimento de um programa para o mapeamento da distribuição de brilho na superfí cie das estrelas secundárias em VCs e BXBMs com técnicas de astro-tomografia. Presentemente temos em operação um código que simula as variações no perfil das linhas em conseqüência de efeito Doppler resultante da combinação de rotação e translação de uma estrela em forma de lobo de Roche em torno do centro de massa da binária, em função da distribuição de brilho na superfície desta estrela. O código igualmente produz a curva de luz resultante das variações de aspecto da estrela em função da fase orbital (variações elipsoidais).

  17. Variation of the anthropic vulnerability in Ribeirão das Pedras watershed in Campinas/SP - Brazil.

    NASA Astrophysics Data System (ADS)

    Damame, Desirée; Longo, Regina; Ribeiro, Admilson; Fengler, Felipe

    2015-04-01

    The human actions has caused over the years profound changes in environmental quality in urban ecosystems suffering losses in the quality of air, soil , water and vegetation also the quality of life of the population that inhabit these areas . The study area is characterized by being a highly urbanized watershed, with about 43 % of its area covered by buildings, houses , and commercial and industrial establishments . Called the Ribeirão das Pedras Basin, located in Campinas / SP - Brazil and is bounded by coordinates 22˚47'10 '' and 22˚52'20 '' S , and 47˚ 07'15 '' and 46˚ 02 ' 15' ' . Has an average temperature of 22.4 ° C and average annual rainfall of 1424.5 mm . It has an area of about 42 km² . This is located two universities and a large mall. It also demands a strong agriculture , which occupies about 30 % of the area . It has also been part of two major forest reserves of the municipality, the Forest Santa Geneva and the Forest of Quilombo , both added to other small fragments overlying only about 6% of the total basin area . Avalição to environmental quality , the analysis of the vulnerability of urban watershed becomes an important environmental management tool. The vulnerability can be defined by susceptibility to changes of environment in its initial state , a current tax status by human intervention , and is almost always associated with risk , and the intensity at which such projects in one place, person or structure. In this context , this study aimed to assess environmental vulnerability in an urban watershed coming under increasing human pressures , especially in recent years . For this analysis were prepared soil graphics, slope , elevation and land use and land cover for the years 2009 and 2014 , generating with these , comparative anthropic vulnerability maps of the past five years. Crafting vulnerability maps is a sensitivity in order to enable appropriate management of biotic systems. With the results can be seen that the variation of

  18. Bottom Characterization with High Resolution Sonar Data and Geochemical Analyses of an Uninvestigated Cone in Lagoa das Furnas on São Miguel Island, Azores Archipelago

    NASA Astrophysics Data System (ADS)

    Andersson, T.

    2015-12-01

    Lagoa das Furnas is a crater lake located in an area exposed to geohazards from earthquakes and volcanic activity on the island São Miguel in the Azores Archipelago. The Furnas volcanic center has a long history of earthquakes and volcanic activity. The area is relatively well studied except for the lake floor. Therefore, a high resolution geophysical and geological mapping survey was conducted at Lagoa das Furnas. Sidescan sonar was used to map the surface of the lake floor and single beam sonar was used to acquire sub-bottom profiles. In addition to the geophysical mapping, sediment surface sampling and core drilling were carried out followed by geochemical analyses of the retrieved material. The mapped data permitted a characterization of the floor of Lagoa das Furnas and revealed several volcanic features including fumarolic activity and a previously uninvestigated volcanic cone in the southern part of the lake. In order to unravel the origin of this cone several methods were applied, including analyses of tephra and minerals collected from the cone itself and from nearby deposits of two known eruptions, Furnas I and Furnas 1630. Sedimentological, petrological, geochemical and geochronological studies of pyroclastic deposits from the cone suggest a subaqueous eruption linked to the Furnas 1630 eruption. The chemistry of glass and crystal fragments sampled from the cone suggests that it is composed of more evolved magma than that of the main Furnas 1630, implying that the lake cone is likely a product of the last eruptional phase. According to historical records, two of three lakes were lost due the Furnas 1630 eruption. The results of this study show that the remaining lake is most likely Lagoa das Furnas, which consequently must have existed before the 1630 eruption.

  19. Comparative morphology of the reproductive system of seven species of ostariophysan fishes from the upper Das Velhas River, Brazil.

    PubMed

    Melo, Rafael Magno Costa; Gomes, Débora Diniz; Moreira, Davidson Peruci; Gomes, Maysa Regina; Bazzoli, Nilo; Rizzo, Elizete

    2017-02-01

    The success of fishes in different environments is related with the variation of reproductive strategies developed by the systematic group, which is reflected in the morphology of the reproductive system and can have ecological and evolutionary implications. This study comparatively analyzed the morphological characteristics of the male and female reproductive systems of ostariophysan fish species from the upper Das Velhas River in the São Francisco River basin, Brazil. In order to accomplish this, 393 specimens belonging to seven fish species were sampled between April 2010 and June 2015 for histological, ultrastructural, histochemical, and morphometric analyses. All the species examined have anastomosing tubular testes with unrestricted distribution of spermatogonia. Astyanax bimaculatus, A. fasciatus, A. scabripinnis, and Harttia torrenticola had their spermatozoa embedded in a glycoprotein secretion within the tubule lumen. Most species had type I spermiogenesis, whereas Rhamdia quelen had type III spermiogenesis. While all females examined had asynchronous oocyte development, there were remarkable morphological, histochemical, and morphometric differences in the ovarian follicles and enveloping layers. Hoplias malabaricus and H. torrenticola, which exhibit parental care behaviour, had a significantly larger diameter of vitellogenic oocytes and larger spermatozoa nuclei. Apareiodon ibitiensis, H. torrenticola, and A. scabripinnis, species that have rheophilic preferences, exhibited a thicker zona radiata than the other species examined. The follicular cells of R. quelen and H. torrenticola were columnar and produced a jelly coat and mucosubstances, respectively. The females of the seven fish species studied show a correlation of the reproductive strategies with the reproductive system morphology, while males retained more similar morphological characteristics between species. J. Morphol. 278:170-181, 2017. © 2016 Wiley Periodicals,Inc. © 2016 Wiley

  20. Ventos em supergigantes B[e] das nuvens de Magalhães e da Galáxia

    NASA Astrophysics Data System (ADS)

    de Araújo, F. X.; Pilling, D. A.; Pereira, C. B.; Fernandes, M. B.

    2003-08-01

    As Supergigantes B[e] apresentam as seguintes características: (i) alta luminosidade; (ii) espectro típico de estrelas de tipo B; (iii) linhas permitidas e proibidas em emissão de metais de baixa ionização, especialmente FeII; (iv) linhas de Balmer, e por vêzes também dos ions HeI e FeII, com perfis tipo P Cygni indicativos de altas taxas de perda de massa. Atualmente estamos desenvolvendo um projeto que visa comparar as propriedades fisicas (principalmente e v¥) dos ventos destes objetos nas Nuvens de Magalhães e na Galaxia. O objetivo é estudar a influência da metalicidade. No presente painel apresentamos uma determinação das velocidades terminais de 11 estrelas, sendo 4 na GNM (Hen S111, 66, R126 e Hen S93), 4 na PNM (Hen S18, S23, S65 e R4) e 3 na Galaxia (CPD-529243, MWC 300 e GG Car). Nossos dados são espectros de alta resolução obtidos no telescópio 1.52m do ESO com o espectrógrafo FEROS. Para determinar as velocidades terminais usamos as linhas Hd e HeI 3888 Å cujas componentes em absorção costumam estar livres de "blends" e estruturas. Nossos resultados sugerem que as velocidades de expansão na GNM são maiores (ainda que apenas ligeiramente) do que aquelas da PNM, como esperado. No entanto, os objetos da Galaxia não parecem seguir a mesma tendência.

  1. Das wissenschaftliche Handbuch

    NASA Astrophysics Data System (ADS)

    Luckenbach, Reiner; Sunkel, Josef

    1981-02-01

    The 100th anniversary of Beilstein's Handbook of Organic Chemistry, founded in 1881, merits a brief description of the principal concepts and goals of the literary genre “scientific handbook” in general. Systematic arrangement, critical data and fact evaluation, thoroughness and reliability are among these goals, thus providing the handbook user with a concise compilation of carefully checked and cross-referenced information in his particular field of interest.

  2. Desenvolvimento das câmeras de raios-X duros do satélite MIRAX

    NASA Astrophysics Data System (ADS)

    Braga, J.; Rothschild, R.; Staubert, R.; Heise, J.; Remillard, R.; D'Amico, F.; Jablonski, F.; Mejía, J.; Carvalho, H.; Heindl, B.; Matteson, J.; Kendziorra, E.; Wilms, J.; in't Zand, J.; Kuulkers, E.

    2003-08-01

    O MIRAX (Monitor e Imageador de RAios-X) é um projeto de desenvolvimento de um pequeno satélite astronômico de raios-X (~200 kg, ~240 W). A estratégia básica da missão será observar continuamente (~9 meses por ano) a região central (~1000 graus2) do plano Galáctico e realizar estudos espectroscópicos de banda larga (2-200 keV) e alta sensibilidade de um grande conjunto de fontes através de imagens com resolução de ~6'. Isso proporcionará uma cobertura inédita do "espaço de descobertas" através da detecção, localização, identificação e estudo detalhado de fenômenos imprevisíveis, tais como transientes fracos de raios-X, novas rápidas de raios-X e bursts de raios gama, assim como o estudo de fontes com emissão persistente. Neste trabalho apresentamos o projeto das duas câmeras de raios-X duros (CXDs) do MIRAX, que irão operar na faixa de 10 a 200 keV. Cada CXD consistirá de um plano de detectores CZT (Cd0,9Zn0,1Te) de 0,5 mm de resolução espacial e 370 cm2 de área total, e de uma máscara codificada com elementos quadrados de 1,3 mm de lado e 0,5 cm de espessura. A máscara terá dimensões de 315 cm ´ 275 cm e será montada a 700 cm de distância dos detectores. Com essa configuração as CXDs terão 6' de resolução angular e, quando colocadas a um ângulo de 29° entre si, as duas câmeras propiciam um campo totalmente codificado de 39° ´ 6°12' e um campo total de 76° ´ 44°. Serão apresentadas simulações de observações da região do plano Galáctico com o conjunto formado pelas duas CXDs.

  3. Soil gas Rn monitoring at Chã das Caldeiras prior the 2014-15 Fogo eruption, Cape Verde

    NASA Astrophysics Data System (ADS)

    Padilla, Germán; Barrancos, José; Dionis, Samara; Fernandes, Paulo; Pérez, Nemesio M.; Sagiya, Takeshi; Padrón, Eleazar; Melián, Gladys V.; Hernández, Pedro A.; Silva, Sónia; Pereira, José Manuel; Rodríguez, Fátima; Asensio-Ramos, María; Calvo, David; Semedo, Helio

    2015-04-01

    Since 2007 the ITER-INVOLCAN/UNICV-OVCV/SNPC research team has implemented a geochemical program for the volcanic surveillance of Fogo volcano by means of applying different geochemical methods in a regularly basis (diffuse degassing surveys, fumarole gas sampling, etc.). This program was improved by setting up a geochemical permanent station (CHA01) to perform continuous measurements of soil gas radon (222Rn) and thoron (220Rn) activities at Chã das Caldeiras, more specific in Portela village, since April 20, 2013. Both gases are characterized to ascend towards the surface mainly through cracks or faults via diffusion and/or advection mechanisms dependent of both soil porosity and permeability, which in turn vary as a function of the stress/strain changes at depth. Measurements of 222Rn and 220Rn activities were performed by an alpha-spectrometer after pumping the soil gas from a thermally isolated PVC pipe inserted 1m in the ground. Even though during the study period the recorded data did not show high 222Rn activity values, a change in the temporal evolution of soil gas 222Rn activity was observed. During the first six months, from April to October, 2013, recorded time series of 222Rn and 220Rn activities showed normal background levels with values of 80.5 and 55.2 Bqm-3, respectively. However, from October, 2013, to February, 2014, 222Rn time series showed an increase trend reaching peak values of 396 Bqm-3 and having an average activity of 134 Bqm-3 until the removal of the station on November 25, 2014 due to the potential danger of being destroyed by the lava flows. The observed increase in the soil gas 222Rn activity from October 2013 to February 2014 occurs almost at the same time of slight observed changes in the vertical displacements detected by the geodetic network installed at the Fogo Island by the ITER-INVOLCAN/UNICV-OVCV/SNPC/Nagoya University research team. Since seismic data are not available, we cannot conclude if the observed changes in soil

  4. Geochemistry of komatiites and basalts from the Rio das Velhas and Pitangui greenstone belts, São Francisco Craton, Brazil: Implications for the origin, evolution, and tectonic setting

    NASA Astrophysics Data System (ADS)

    Verma, Sanjeet K.; Oliveira, Elson P.; Silva, Paola M.; Moreno, Juan A.; Amaral, Wagner S.

    2017-07-01

    The Neoarchean Rio das Velhas and Pitangui greenstone belts are situated in the southern São Francisco Craton, Minas Gerais, Brazil. These greenstone belts were formed between ca. 2.79-2.73 Ga, and consist mostly of mafic to ultramafic volcanics and clastic sediments, with minor chemical sediments and felsic volcanics that were metamorphosed under greenschist facies. Komatiites are found only in the Rio das Velhas greenstone belt, which is composed of high-MgO volcanic rocks that have been identified as komatiites and high-Mg basalts, based on their distinctive geochemical characteristics. The Rio das Velhas komatiites are composed of tremolite + actinolite + serpentine + albite with a relict spinifex-texture. The Rio das Velhas komatiites have a high magnesium content ((MgO)adj ≥ 28 wt.%), an Al-undepleted Munro-type [(Al2O3/TiO2)adj and (CaO/Al2O3)adj] ratio ranging from 27 to 47 and 0.48 to 0.89, relatively low abundances of incompatible elements, a depletion of light rare earth elements (LREE), a pattern of non-fractionated heavy rare- earth elements (HREE), and a low (Gd/Yb)PM ratio (≤ 1.0). Negative Ce anomalies suggest that alteration occurred during greenschist facies metamorphism for the komatiites and high-Mg basalts. The low [(Gd/Yb)PM < 1.0] and [(CaO/Al2O3)adj < 0.9)], high [(Al2O3/TiO2)adj > 18] and high HREE, Y, and Zr content suggest that the Rio das Velhas komatiites were derived from the shallow upper mantle without garnet involvement in the residue. The chemical compositions [(Al2O3/TiO2)adj, (FeO)adj, (MgO)adj, (CaO/Al2O3)adj, Na, Th, Ta, Ni, Cr, Zr, Y, Hf, and REE] indicate that the formation of the komatiites, high-Mg basalts and basalts occurred at different depths and temperatures in a heterogeneous mantle. The komatiites and high-Mg basalts melted at liquidus temperatures of 1450-1550 °C. The Pitangui basalts are enriched in the highly incompatible LILE (large-ion lithophile elements) relative to the moderately incompatible HFS (high

  5. Challenges for bathing in rivers in terms of compliance with coliform standards. Case study in a large urbanized basin (das Velhas River, Brazil).

    PubMed

    von Sperling, Marcos; von Sperling, Eduardo

    2013-01-01

    This paper presents a case study on the prospects of bathing in a large water course (das Velhas River, Brazil), which crosses the important metropolitan region of Belo Horizonte (25 municipalities), receiving several point and diffuse discharges. The studies were carried out based on a mathematical simulation of thermotolerant coliforms over 227 km of the river, using an adaptation of the Qual2E model (model Qual-UFMG). Simulations of intervention scenarios were made for the current conditions, with three reference flows for the das Velhas River, tributaries and direct contribution: Q7,10 (representative of low-flow conditions), Q50 (average conditions) and Q10 (rainy season). The intervention scenarios simulated were: (a) current conditions without intervention; (b) scenario with effluent disinfection in the two largest wastewater treatment plants in the basin (around 2.4 million inhabitants); (c) scenario with 95% sewage collection and treatment, with disinfection in all municipalities of the study area; (d) scenario with the calculation of values required for the coverage of sewage treatment and coliform removal efficiencies based on a mathematical optimization process. The monitoring data and results of all simulations indicated improvement in coliform concentration as the river flows downstream. However, results suggested that disinfection per se is not enough. Even under hypothetical conditions of excellent sanitary infrastructure for a developing country, coverage of collection and treatment of 95% of the generated sewage, and treatment with disinfection at all wastewater treatment plants, concentrations of thermotolerant coliforms in das Velhas River are likely to be above the maximum allowable of 1,000 MPN/100 mL for bathing purposes. The mathematical optimization indicated the need for very high percentages of sewage treatment coverage (near 100%, i.e. universality of collection and treatment) and implementation of disinfection in most treatment plants

  6. Data Integration Acquired from Micro-Uav and Terrestrial Laser Scanner for the 3d Mapping of Jesuit Ruins of São Miguel das Missões

    NASA Astrophysics Data System (ADS)

    Reiss, M. L. L.; da Rocha, R. S.; Ferraz, R. S.; Cruz, V. C.; Morador, L. Q.; Yamawaki, M. K.; Rodrigues, E. L. S.; Cole, J. O.; Mezzomo, W.

    2016-06-01

    The Jesuit Missions the Guaranis were one of the great examples of cultural, social, and scientific of the eighteenth century, which had its decline from successive wars that followed the exchange of territories domain occupied by Portugal and Spain with the Madrid Treaty of January 13, 1750. One of the great examples of this development is materialized in the ruins of 30 churches and villages that remain in a territory that now comprises part of Brazil, Argentina and Paraguay. These Churches, São Miguel das Missões is among the Brazilian ruins, the best preserved. The ruins of São Miguel das Missões were declared a UNESCO World Cultural Heritage in 1983 and the Institute of National Historical Heritage (IPHAN) is the Brazilian Federal agency that manages and maintains this heritage. In order to produce a geographic database to assist the IPHAN in the management of the Ruins of São Miguel das Missões it was proposed a three-dimensional mapping of these ruins never performed in this location before. The proposal is integrated data acquired from multiple sensors: two micro-UAV, an Asctec Falcon 8 (rotary wing) and a Sensefly e-Bee (fixed wing); photos from terrestrial cameras; two terrestrial LIDAR sensors, one Faro Focus 3D S-120 and Optec 3D-HD ILRIS. With this abundance of sensors has been possible to perform comparisons and integration of the acquired data, and produce a 3D reconstruction of the church with high completeness and accuracy (better than 25 mm), as can be seen in the presentation of this work.

  7. Seismic Monitoring of Permafrost During Controlled Thaw: An Active-Source Experiment Using a Surface Orbital Vibrator and Fiber-Optic DAS Arrays

    NASA Astrophysics Data System (ADS)

    Dou, S.; Wood, T.; Lindsey, N.; Ajo Franklin, J. B.; Freifeld, B. M.; Gelvin, A.; Morales, A.; Saari, S.; Ekblaw, I.; Wagner, A. M.; Daley, T. M.; Robertson, M.; Martin, E. R.; Ulrich, C.; Bjella, K.

    2016-12-01

    Thawing of permafrost can cause ground deformations that threaten the integrity of civil infrastructure. It is essential to develop early warning systems that can identify critically warmed permafrost and issue warnings for hazard prevention and control. Seismic methods can play a pivotal role in such systems for at least two reasons: First, seismic velocities are indicative of mechanical strength of the subsurface and thus are directly relevant to engineering properties; Second, seismic velocities in permafrost systems are sensitive to pre-thaw warming, which makes it possible to issue early warnings before the occurrence of hazardous subsidence events. However, several questions remain: What are the seismic signatures that can be effectively used for early warning of permafrost thaw? Can seismic methods provide enough warning times for hazard prevention and control? In this study, we investigate the feasibility of using permanently installed seismic networks for early warnings of permafrost thaw. We conducted continuous active-source seismic monitoring of permafrost that was under controlled heating at CRREL's Fairbanks permafrost experiment station. We used a permanently installed surface orbital vibrator (SOV) as source and surface-trenched DAS arrays as receivers. The SOV is characterized by its excellent repeatability, automated operation, high energy level, and the rich frequency content (10-100 Hz) of the generated wavefields. The fiber-optic DAS arrays allow continuous recording of seismic data with dense spatial sampling (1-meter channel spacing), low cost, and low maintenance. This combination of SOV-DAS provides unique seismic datasets for observing time-lapse changes of warming permafrost at the field scale, hence providing an observational basis for design and development of early warning systems for permafrost thaw.

  8. ACR/EULAR Definitions of Remission Are Associated with Lower Residual Inflammatory Activity Compared with DAS28 Remission on Hand MRI in Rheumatoid Arthritis.

    PubMed

    Lisbona, Maria Pilar; Solano, Albert; Ares, Jesús; Almirall, Miriam; Salman-Monte, Tarek Carlos; Maymó, Joan

    2016-09-01

    To determine the level of residual inflammation [synovitis, bone marrow edema (BME), tenosynovitis, and total inflammation] quantified by hand magnetic resonance imaging (h-MRI) in patients with rheumatoid arthritis (RA) in remission according to 3 different definitions of clinical remission, and to compare these remission definitions. A cross-sectional study. To assess the level of residual MRI inflammation in remission, cutoff levels associated to remission and median scores of MRI residual inflammatory lesions were calculated. Data from an MRI register of patients with RA who have various levels of disease activity were used. These were used for the analyses: synovitis, BME according to the Rheumatoid Arthritis Magnetic Resonance Imaging Scoring system, tenosynovitis, total inflammation, and disease activity composite measures recorded at the time of MRI. Receiver-operating characteristic analysis was used to identify the best cutoffs associated with remission for each inflammatory lesion on h-MRI. Median values of each inflammatory lesion for each definition of remission were also calculated. A total of 388 h-MRI sets of patients with RA with different levels of disease activity, 130 in remission, were included. Cutoff values associated with remission according to the Simplified Disease Activity Index (SDAI) ≤ 3.3 and the Boolean American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) definitions for BME and tenosynovitis (1 and 3, respectively) were lower than BME and tenosynovitis (2 and 5, respectively) for the Disease Activity Score on 28 joints (DAS28) ≤ 2.6. Median scores for synovitis, BME, and total inflammation were also lower for the SDAI and Boolean ACR/EULAR remission criteria compared with DAS28. Patients with RA in remission according to the SDAI and Boolean ACR/EULAR definitions showed lower levels of MRI-detected residual inflammation compared with DAS28.

  9. Comment on the use of self-reporting instruments to assess patients with rheumatoid arthritis: the longitudinal association between the DAS28 and the VAS general health.

    PubMed

    Kievit, W; Welsing, P M J; Adang, E M M; Eijsbouts, A M; Krabbe, P F M; van Riel, P L C M

    2006-10-15

    Recently, the use of patient self-reporting instruments instead of clinical, objective measurements to assess rheumatoid arthritis (RA) patients was proposed. This assumes a constant association between disease activity and the self-reporting instruments. The objective was to explore the association (in time) between disease activity and patient perception of general health, disease activity, pain, and functional disability in patients with RA. Data of 624 newly diagnosed RA patients who completed 3 years of followup were analyzed. Cross-sectional linear regression models and longitudinal regression models were estimated, with a visual analog scale (VAS) measuring general health (VAS-GH; 0 = best, 100 = worst) as a dependent variable and the Disease Activity Score (DAS28) without the VAS-GH as an independent variable. Other dependent variables were VAS disease activity, pain, and the Health Assessment Questionnaire. The DAS28 and VAS-GH were significantly associated in RA patients (P < 0.001). However, the explained variance was low (6.7%). From diagnosis to 3 years after the diagnosis, the intercept decreased given the same regression coefficient. The longitudinal regression model showed that the VAS-GH improved during disease course independent of a change in DAS28. Analyses on the other outcome parameters showed similar results. Patients' perception of health can be different with equal disease activity, depending on the moment in the disease course. Furthermore, our results indicate that self-reported measures on functionality, disease activity, and general health cannot substitute for objective measures of disease activity in RA in longitudinal studies; subsequently, both need to be measured.

  10. [Spanish version of the new World Health Organization Disability Assessment Schedule II (WHO-DAS-II): initial phase of development and pilot study. Cantabria disability work group].

    PubMed

    Vázquez-Barquero, J L; Vázquez Bourgón, E; Herrera Castanedo, S; Saiz, J; Uriarte, M; Morales, F; Gaite, L; Herrán, A; Ustün, T B

    2000-01-01

    The aim of the present paper is to present the initial phases of the development of the Spanish version of the "World Health Organization Disablement Assessment Schedule II" WHO-DAS-II and also to describe the quantitative and qualitative methodological strategies used in the elaboration process of an instrument: i) compatible with the new International Classification of Functioning and Disability -ICIDH-2- of the World Health Organisation; ii) with criteria of cross-cultural applicability and; iii) to allow us to assess the disability in all its dimensions.

  11. DasPy 1.0 - the Open Source Multivariate Land Data Assimilation Framework in combination with the Community Land Model 4.5

    NASA Astrophysics Data System (ADS)

    Han, X.; Li, X.; He, G.; Kumbhar, P.; Montzka, C.; Kollet, S.; Miyoshi, T.; Rosolem, R.; Zhang, Y.; Vereecken, H.; Franssen, H.-J. H.

    2015-08-01

    Data assimilation has become a popular method to integrate observations from multiple sources with land surface models to improve predictions of the water and energy cycles of the soil-vegetation-atmosphere continuum. Multivariate data assimilation refers to the simultaneous assimilation of observation data from multiple model state variables into a simulation model. In recent years, several land data assimilation systems have been developed in different research agencies. Because of the software availability or adaptability, these systems are not easy to apply for the purpose of multivariate land data assimilation research. We developed an open source multivariate land data assimilation framework (DasPy) which is implemented using the Python script language mixed with the C++ and Fortran programming languages. LETKF (Local Ensemble Transform Kalman Filter) is implemented as the main data assimilation algorithm, and uncertainties in the data assimilation can be introduced by perturbed atmospheric forcing data, and represented by perturbed soil and vegetation parameters and model initial conditions. The Community Land Model (CLM) was integrated as the model operator. The implementation allows also parameter estimation (soil properties and/or leaf area index) on the basis of the joint state and parameter estimation approach. The Community Microwave Emission Modelling platform (CMEM), COsmic-ray Soil Moisture Interaction Code (COSMIC) and the Two-Source Formulation (TSF) were integrated as observation operators for the assimilation of L-band passive microwave, cosmic-ray soil moisture probe and land surface temperature measurements, respectively. DasPy has been evaluated in several assimilation studies of neutron count intensity (soil moisture), L-band brightness temperature and land surface temperature. DasPy is parallelized using the hybrid Message Passing Interface and Open Multi-Processing techniques. All the input and output data flows are organized efficiently

  12. Agronomic performance of insect-protected and herbicide-tolerant MON 89034 × TC1507 × NK603 × DAS-40278-9 corn is equivalent to that of conventional corn.

    PubMed

    Cerqueira, Denise T Rezende de; Schafer, Ariane C; Fast, Brandon J; Herman, Rod A

    2017-03-31

    Agronomic characteristics of genetically modified (GM) MON 89034 × TC1507 × NK603 × DAS-40278-9 (PowerCore™ Enlist™), MON 89034 × TC1507 × NK603 (PowerCore™), and DAS-40278-9 (Enlist™) corn, a non-GM near-isogenic hybrid, and two commercial non-GM hybrids were assessed in a field study to determine if the agronomic performance of the GM corn hybrids is equivalent to that of non-transgenic hybrid corn. The MON 89034 × TC1507 × NK603 × DAS-40278-9 hybrid corn was developed through stacking of four individual transgenic events, MON 89034, TC1507, NK603, and DAS-40278-9 by traditional breeding and contains the cry1A.105 and cry2Ab2 (MON 89034), cry1F and pat (TC1507), cp4 epsps (NK603) and aad-1 (DAS-40278-9) transgenes. These transgenes encode the proteins Cry1A.105, Cry2Ab2, and Cry1F, which confer insect resistance, PAT, CP4 EPSPS, and AAD-1, which confer herbicide tolerance. The following agronomic characteristics were assessed in the study: initial and final stand count, seedling vigor, time to silk, time to pollen shed, pollen viability, plant height, ear height, stalk lodging, root lodging, days to maturity, stay green, disease incidence, insect damage, herbicide injury, and yield. The agronomic assessment was conducted in two regions of Brazil (Indianopolis-MG; Cravinhos-SP). The agronomic attributes for all GM entries were statistically indistinguishable from the non-GM near-isogenic hybrid. In addition, most of the agronomic assessments fell within the range of the commercial varieties included in the study. Taken together, MON 89034 × TC1507 × NK603 × DAS-40278, MON 89034 × TC1507 × NK603, and DAS-40278-9 were found to be agronomically equivalent to non-GM corn.

  13. Alterations in the immunohistochemical expression of Das-1 and CG-3 in colonic mucosal biopsy specimens helps distinguish ulcerative colitis from Crohn disease and from other forms of colitis.

    PubMed

    Yantiss, Rhonda K; Das, Kiron M; Farraye, Francis A; Odze, Robert D

    2008-06-01

    Distinction between ulcerative colitis (UC) and Crohn disease (CD) in mucosal biopsies is often difficult. Das-1 and CG-3 are monoclonal antibodies directed against an unknown colonic epithelial protein and human tropomyosin isoform-5, respectively, both show altered expression in patients with UC. In this study, we evaluated the utility of Das-1 and CG-3 in distinguishing UC from CD and from other types of colitis. One colonic biopsy specimen from each of 85 patients with confirmed UC (n=25), CD (n=15), lymphocytic (n=15), collagenous (n=15), and ischemic (n=15) colitis, and also 10 samples from normal controls, were stained for Das-1 and CG-3 using standard techniques. Reactivity for Das-1 and CG-3 was noted to be absent or present, and the location (ie, surface+/-crypt epithelium) and degree (weak or strong) of CG-3 staining was recorded. Loss of Das-1 staining occurred more frequently in UC (96%) compared with CD (20%), lymphocytic (20%), collagenous (13%), and ischemic colitis (0%) cases, as well as controls (10%, P<0.001 for all comparisons). CG-3 positivity in crypt epithelium was significantly more common in UC (52%) compared with the other groups (P< or =0.02 for all comparisons). The combination of strong crypt CG-3 staining and loss of Das-1 staining was noted in 44% of UC cases, but not in any other type of colitis (P=0.003 for all comparisons). We conclude that the patterns of Das-1 and CG-3 staining in colonic mucosal biopsies may be clinically useful in distinguishing UC from CD and from other colitidies.

  14. [Maternal mortality in the Hospital das Clinicas, Faculdade de Medicina de Ribeirao Preto (USP) from 1957 to 1977. Pt. 1: Incidence (Author's transl)].

    PubMed

    Parente, J V; Martinez, A R; Franco Jg; De Carvalho, R L; Carravazzo, N C; Meirelles, R S

    1979-08-01

    A study was carried out from 1957-1977 which investigated the incidence of maternal mortality in the Hospital das Clinicas, Faculdade de Medicina de Ribeirao Preto. The yearly distribution of these deaths related to the resolution of pregnancy always showed predominance of the abortion group over the others (pregnant patients, normal delivery, and surgical delivery), with increased evidence starting at the beginning of the 1970's. When the deaths were distributed by relating pregnancy resolution to marital status, absolute predominance of married over single patients was observed, including the abortion group. When the site of the 21st obstetrical aid was considered, it was observed that in 17 of 68 cases studied, the patients were directed to another hospital or delivered at home assisted by a midwife. The mortality rate for the entire period studied was 22.04%. When the cases receiving 1st obstetrical aid outside the Hospital das Clinicas are subtracted, the rate drops to 16.53% and to 8.1% when the abortion group is also excluded. On the basis of these data, it was concluded that abortion is the greatest medical-social problem detected in this study.

  15. Development of multiplex PCR method for simultaneous detection of four events of genetically modified maize: DAS-59122-7, MIR604, MON863 and MON88017.

    PubMed

    Oguchi, Taichi; Onishi, Mari; Mano, Junichi; Akiyama, Hiroshi; Teshima, Reiko; Futo, Satoshi; Furui, Satoshi; Kitta, Kazumi

    2010-01-01

    A novel multiplex PCR method was developed for simultaneous event-specific detection of four events of GM maize, i.e., DAS-59122-7, MIR604, MON88017, and MON863. The single laboratory examination of analytical performance using simulated DNA mixtures containing GM DNA at various concentrations in non-GM DNA suggested that the limits of detection (LOD) of the multiplex PCR method were 0.16% for MON863, MIR604, and MON88017, and 0.078% for DAS-59122-7. We previously developed a nonaplex (9plex) PCR method for eight events of GM maize, i.e., Bt11, Bt176, GA21, MON810, MON863, NK603, T25, and TC1507. Together with the nonaplex PCR method, the newly developed method enabled the detection and identification of eleven GM maize events that are frequently included in commercial GM seed used in Japan. In addition, this combinational analysis may be useful for the identification of combined event products of GM maize.

  16. Metabolism and Residues of 2,4-Dichlorophenoxyacetic Acid in DAS-40278-9 Maize (Zea mays) Transformed with Aryloxyalkanoate Dioxygenase-1 Gene.

    PubMed

    Zhou, Xiao; Rotondaro, Sandra L; Ma, Mingming; Rosser, Steve W; Olberding, Ed L; Wendelburg, Brian M; Adelfinskaya, Yelena A; Balcer, Jesse L; Blewett, T Craig; Clements, Bruce

    2016-10-12

    DAS-40278-9 maize, which is developed by Dow AgroSciences, has been genetically modified to express the aryloxyalkanoate dioxygenase-1 (AAD-1) protein and is tolerant to phenoxy auxin herbicides, such as 2,4-dichlorophenoxyacetic acid (2,4-D). To understand the metabolic route and residue distribution of 2,4-D in DAS-40278-9 maize, a metabolism study was conducted with (14)C-radiolabeled 2,4-D applied at the maximum seasonal rate. Plants were grown in boxes outdoors. Forage and mature grain, cobs, and stover were collected for analysis. The metabolism study showed that 2,4-D was metabolized to 2,4-dichlorophenol (2,4-DCP), which was then rapidly conjugated with glucose. Field-scale residue studies with 2,4-D applied at the maximum seasonal rate were conducted at 25 sites in the U.S. and Canada to measure the residues of 2,4-D and free and conjugated 2,4-DCP in mature forage, grain, and stover. Residues of 2,4-D were not detectable in the majority of the grain samples and averaged <1.0 and <1.5 μg/g in forage and stover, respectively. Free plus conjugated 2,4-DCP was not observed in grain and averaged <1.0 μg/g in forage and stover.

  17. Brazil's premier gold province. Part I: The tectonic, magmatic, and structural setting of the Archean Rio das Velhas greenstone belt, Quadrilátero Ferrífero

    NASA Astrophysics Data System (ADS)

    Lobato, Lydia; Ribeiro-Rodrigues, Luiz; Zucchetti, Márcia; Noce, Carlos; Baltazar, Orivaldo; da Silva, Luiz; Pinto, Claiton

    2001-07-01

    Rocks of the Rio das Velhas Supergroup comprise one of the most significant Archean greenstone-belt successions in Brazil, in both their appreciable mineral productivity and extensive mineral potential. A large part of this greenstone belt is contained within the Quadrilátero Ferrífero (Iron Quadrangle) region, Minas Gerais state, southeastern Brazil, which occupies the southernmost portion of the São Francisco craton. The Nova Lima Group rocks, at the base of the Rio das Velhas greenstone belt, host important orogenic gold deposits. The group contains lithological associations from bottom to top as follows: (1) mafic-ultramafic volcanic, (2) volcanic-chemical, (3) clastic-chemical, (4) volcaniclastic, and (5) resedimented rocks. Rocks of the resedimented, volcanic-chemical, and mafic-ultramafic volcanic associations mainly host the most important gold deposits. An early compressional deformation occurs in the rocks of the Rio das Velhas greenstone belt and basement gneisses, with tangential thrusting from the north to the south or southwest. Structures generated during a second, compressional deformation, encompass NW-striking thrust faults and SW-vergent, tight to isoclinal folds, inferring a general southwest transport direction. In the central portion of the Quadrilátero Ferrífero, the Paciência lineament, which strikes northwest and dips to the northeast in the south, or strikes northeast and dips to the southeast in the north, is a thrust-related, oblique ramp fault that hosts important gold deposits. The convergence of these two trends in the Nova Lima region is accommodated by roughly E-W-striking transcurrent faults, which are the most favored sites for large gold concentrations. Intracratonic extension in Late Archean to early Paleoproterozoic times and NW-vergent, Trans-Amazonian compressional deformation post-date gold deposition. Late extension during the Paleoproterozoic led to basin formation and the prominent dome-and-keel architecture of the

  18. Feeling Normal? Long-Term Follow-up of Patients with a Cleft Lip-Palate after Rhinoplasty with the Derriford Appearance Scale (DAS-59).

    PubMed

    Albers, Andreas E; Reichelt, Andreas C; Nolst-Trenité, Gilbert J; Menger, Dirk Jan

    2016-04-01

    The stigma of nasal deformity due to a congenital cleft lip-palate has an undeniable influence on the affected patient's life. It is therefore of interest to investigate if efforts to reduce esthetic and functional impairments by rhinoplasty (single or multiple) can result in an increased satisfaction with appearance and a self-perception similar to the noncleft population. Retrospective scoring before and after rhinoplasty using the validated Derriford Appearance Scale (DAS-59) and subsequent statistical evaluation and comparison to datasets available in the literature for further classification was used. Of the 61 patients who underwent at least one rhinoplasty, 26 responded to all questions. The mean age of responders was approximately 30 years of age and the male:female ratio was 1:1.2. The scale showed a significant overall improvement after surgery. The full scale and all subscale scores of the DAS-59 were significantly reduced after surgery demonstrating an improvement in the respective categories. Most importantly, if postoperative results were compared with a population concerned and unconcerned about appearance, no difference "facial self-consciousness" of appearance was apparent. Also postoperative subscores for "general self-consciousness" (GSC) and "social self-consciousness" of appearance (SSC) showed no difference from those obtained from the population concerned about appearance. The postoperative subscore for "sexual and bodily self-consciousness" of appearance (SBSC) indicated improvement beyond the level found in the concerned control population. Due to only a low improvement in the difference compared with the subscore representing a "negative self-concept," a statistically significant difference to the concerned population remained, possibly indicating that therapy beyond surgery is needed for improvement. After rhinoplasty, the investigated group of cleft lip-palate patients with nasal deformities showed an improvement in their self

  19. Relationship between time-integrated disease activity estimated by DAS28-CRP and radiographic progression of anatomical damage in patients with early rheumatoid arthritis

    PubMed Central

    2011-01-01

    Background The main aim of the study was to investigate the relationship between persistent disease activity and radiographic progression of joint damage in early rheumatoid arthritis (ERA). Methods Forty-eight patients with active ERA was assessed every 3 months for disease activity for 3 years. Radiographic damage was measured by the Sharp/van der Heijde method (SHS). The cumulative inflammatory burden was estimated by the time-integrated values (area under the curve-AUC) of Disease Activity Score 28 joint based on C-reactive protein (DAS28-CRP) in rapid progressors versus non-progressors. Bland and Altman's 95% limits of agreement method were used to estimate the smallest detectable difference (SDD) of radiographic progression. The relationship between clinical and laboratory predictors of radiographic progression and their interactions with time was analysed by logistic regression model. Results After 3-years of follow-up, radiographic progression was observed in 54.2% (95%CI: 39.8% to 67.5%) of patients and SDD was 9.5 for total SHS. The percentage of patients with erosive disease increased from 33.3% at baseline to 76% at 36 months. The total SHS of the progressors worsened from a median (interquartile range) of 18.5 (15-20) at baseline to 38.5 (34-42) after 3 years (p < 0.0001) whereas non-progressors worsened from a median of 14.5 (13-20) at baseline to 22.5 (20-30) after 3 years (p < 0.001). In the regression model, time-integrated values of DAS28-CRP and anti-CCP positivity have the highest positive predictive value for progression (both at level of p < 0.0001). Radiographic progression was also predicted by a positive IgM-RF (p0.0009), and a high baseline joint damage (p = 0.0044). Conclusions These data indicate that the level of disease activity, as measured by time-integrated DAS28-CRP, anti-CCP and IgM-RF positivity and a high baseline joint damage, affects subsequent progression of radiographic damage in ERA. PMID:21624120

  20. Short-term monitoring of a gas seep field in the Katakolo bay (Western Greece) using Raman spectra DTS and DAS fibre-optic methods

    NASA Astrophysics Data System (ADS)

    Chalari, A.; Mondanos, M.; Finfer, D.; Christodoulou, D.; Kordella, S.; Papatheodorou, G.; Geraga, M.; Ferentinos, G.

    2012-12-01

    A wide submarine seep of thermogenic gas in the Katakolo bay, Western Greece, was monitored passively using the intelligent Distributed Acoustic Sensor (iDAS) and Ultima Raman spectra Distributed Temperature Sensor (DTS), in order to study the thermal and noise signal of the bubble plumes released from the seafloor. Katakolo is one one of the most prolific thermogenic gas seepage zones in Europe and the biggest methane seep ever reported in Greece. Very detailed repetitive offshore gas surveys, including marine remote sensing (sub-bottom profiling, side scan sonar), underwater exploration by a towed instrumented system (MEDUSA), long-term monitoring benthic station (GMM), compositional and isotopic analyses, and flux measurements of gas, showed that: (a) gas seepage takes place over an extended area in the Katakolo harbour and along two main normal faults off the harbour; (b) at least 823 gas bubble ( 10-20 cm in diameter) plumes escaping over an area of 94,200 m2, at depths ranging from 5.5 to 16 m; (c) the gas consists mainly of methane and has H2S levels of hundreds to thousands ppmv, and shows significant amounts of other light hydrocarbons like ethane, propane, iso-butane and C6 alkanes, (d) offshore and onshore seeps release the same type of thermogenic gas; (e) due to the shallow depth, more than 90 % of CH4 released at the seabed enters the atmosphere, and (f) the gas seeps may produce severe geohazards for people, buildings and construction facilities due to the explosive and toxicological properties of methane and hydrogen sulfide, respectively. For the short-term monitoring, the deployment took place on a site located inside the harbour of Katakolo within a thermogenic gas seepage area where active faults are intersected. The iDAS system makes it possible to observe the acoustical signal along the entire length of an unmodified optical cable without introducing any form of point sensors such as Bragg gratings. When the bubble plumes are released by the

  1. Dating human occupation at Toca do Serrote das Moendas, São Raimundo Nonato, Piauí-Brasil by electron spin resonance and optically stimulated luminescence.

    PubMed

    Kinoshita, Angela; Skinner, Anne R; Guidon, Niede; Ignacio, Elaine; Felice, Gisele Daltrini; Buco, Cristiane de A; Tatumi, Sonia; Yee, Márcio; Figueiredo, Ana Maria Graciano; Baffa, Oswaldo

    2014-12-01

    Excavation of Toca do Serrote das Moendas, in Piauí state, Brazil revealed a great quantity of fossil wild fauna associated with human remains. In particular, fossils of a cervid (Blastocerus dichotomus) were found, an animal frequently pictured in ancient rock wall paintings. In a well-defined stratum, two loose teeth of this species were found in close proximity to human bones. The teeth were independently dated by electron spin resonance (ESR) in two laboratories. The ages obtained for the teeth were 29 ± 3 ka (thousands of years) and 24 ± 1 ka. The concretion layer capping this stratum was dated by optically stimulated luminescence (OSL) of the quartz grains to 21 ± 3 ka. As these values were derived independently in three different laboratories, using different methods and equipment, these results are compelling evidence of early habitation in this area.

  2. Registry of Hospital Das Clínicas of the University of São Paulo Medical School: First Official Solid Organ and Tissue Transplantation Report – 2008

    PubMed Central

    Azeka, Estela; Auler Júnior, José Otavio Costa; Fernandes, Paulo Manuel Pego; Nahas, Willian Carlos; Fiorelli, Alfredo Inácio; Tannuri, Uenis; Cristofani, Lílian Maria; Caiero, Marcelo Tadeu; Dulley, Frederico Luiz; de Oliveira Paggiaro, André; Bacchella, Telesforo

    2009-01-01

    OBJECTIVE: The aim of this study was to report a single center experience of organ and tissue transplantation INTRODUCTION: This is the first report of organ and tissue transplantation at the Hospital das Clínicas of the University of Sao Paulo Medical School. METHODS: We collected data from each type of organ transplantation from 2002 to 2007. The data collected were patient characteristics and actuarial survival Kaplan-Meier curves at 30 days, one year, and five years RESULTS: There were a total of 3,321 transplants at our institution and the 5-year survival curve ranged from 53% to 88%. CONCLUSION: This report shows that solid organ and tissue transplants are feasible within the institution and allow us to expect that the quality of transplantation will improve in the future. PMID:19219318

  3. Application of a Fibre Optic Distributed Acoustic Sensor (DAS) for Shallow Seismic Investigations of a Fractured Dolostone Aquifer in Guelph, Ontario.

    NASA Astrophysics Data System (ADS)

    Munn, J. D.; Parker, B. L.; Coleman, T. I.; Mondanos, M.; Chalari, A.

    2014-12-01

    Understanding groundwater flow and contaminant transport in fractured bedrock aquifers requires detailed characterization of the discrete features that control flow, as well as the properties of the rock matrix. This requires multiple, high-resolution, depth discrete datasets that provide different, but complementary information. Distributed fibre optic sensing is a relatively new technology used to continuously monitor properties along the entire length of an optical fibre. Technological advances over the past few years have brought the sensitivity and spatial resolution to the point where shallow (<200m) borehole applications are practicable. Recent studies using fibre optic distributed temperature sensors (DTS) have shown excellent application of DTS for characterizing groundwater flow in both continuously sealed and open boreholes. This presentation highlights the results of a field trial at the Bedrock Aquifer Research Station on the University of Guelph campus (Ontario, Canada) where a single fibre optic cable was interrogated by both a DTS (Ultima-DTS) and a Distributed Acoustic Sensor (iDAS). DAS is a relatively recent development that allows an optical fibre to be used as a receiver for seismic imaging. These seismic images are produced by sending an optical pulse down the fibre and analyzing the effects of seismic waves on the propagating light. Numerous vertical seismic profiles were collected and the effects of different fibre optic cable structures and coupling techniques were examined. The seismic profiles will help delineate structural features and lithological contacts away from the borehole wall, and will assist in correlating other geophysical, hydraulic, or geological logs collected in the boreholes across the site. Preliminary results show promise for shallow seismic imaging and continued field trials will allow refinement of the technique.

  4. Evaluation of two evidence-based knowledge transfer interventions for physicians. A cluster randomized controlled factorial design trial: the CardioDAS Study.

    PubMed

    Amsallem, Emmanuel; Kasparian, Christelle; Cucherat, Michel; Chabaud, Sylvie; Haugh, Margaret; Boissel, Jean-Pierre; Nony, Patrice

    2007-12-01

    To investigate the potential benefits of two modes of evidence-based knowledge transfer ('active' and 'passive' modes) in terms of improvement of intention of prescription, knowledge, and real prescription in practice, we performed an open randomized controlled trial (CardioDAS) using a factorial design (two tested interventions: 'active' and 'passive' knowledge transfer) and a hierarchical structure (cluster of physicians for each department level). The participants were cardiologists working in French public hospitals. In the 'passive' transfer group, cardiologists received evidence-based knowledge material (available on Internet) every week for a duration of 1 year. In the 'active' transfer group, two knowledge brokers (EA, PN) visited the participating departments (every 2 months for 1 year, 2 h per visit). The primary outcome consisted in the adjusted absolute mean variation of score (difference between post- and pre-study session) of answers to simulated cases assessing the intention to prescribe. Secondary outcomes were the variation of answers to a multiple-choice questionnaire (MCQ) assessing knowledge and of the conformity of real prescriptions to evidence-based reference assessing the behavioral change. Twenty-two French units (departments) of cardiology were randomized (72 participating cardiologists). In the 'active' transfer group, the primary outcome was more improved than that in the control (P = 0.031 at the department level, absolute mean improvement of 5 points/100). The change in knowledge transfer (MCQ) was also significant (P = 0.039 at the department level, absolute mean improvement of 6 points/100). However, no benefit was shown in terms of prescription conformity to evidence. For the 'passive' mode of knowledge transfer and for the three outcomes considered, no improvement was identified. CardioDAS findings confirm that 'active' knowledge transfer has some impact on participants' intent to prescribe and knowledge, but no effect on

  5. Simultaneous functions of the installed DAS/DAK formaldehyde-assimilation pathway and the original formaldehyde metabolic pathways enhance the ability of transgenic geranium to purify gaseous formaldehyde polluted environment.

    PubMed

    Zhou, Shengen; Xiao, Sunqin; Xuan, Xiuxia; Sun, Zhen; Li, Kunzhi; Chen, Limei

    2015-04-01

    The overexpression of dihydroxyacetone synthase (DAS) and dihydroxyacetone kinase (DAK) from methylotrophic yeasts in chloroplasts created a photosynthetic formaldehyde (HCHO)-assimilation pathway (DAS/DAK pathway) in transgenic tobacco. Geranium has abilities to absorb and metabolize HCHO. Results of this study showed that the installed DAS/DAK pathway functioning in chloroplasts greatly enhanced the role of the Calvin cycle in transgenic geranium under high concentrations of gaseous HCHO stress. Consequently, the yield of sugars from HCHO-assimilation increased approximately 6-fold in transgenic geranium leaves, and concomitantly, the role of three original HCHO metabolic pathways reduced, leading to a significant decrease in formic acid, citrate and glycine production from HCHO metabolism. Although the role of three metabolic pathways reduced in transgenic plants under high concentrations of gaseous HCHO stress, the installed DAS/DAK pathway could still function together with the original HCHO metabolic pathways. Consequently, the gaseous HCHO-resistance of transgenic plants was significantly improved, and the generation of H2O2 in the transgenic geranium leaves was significantly less than that in the wild type (WT) leaves. Under environmental-polluted gaseous HCHO stress for a long duration, the stomata conductance of transgenic plants remained approximately 2-fold higher than that of the WT, thereby increasing its ability to purify gaseous HCHO polluted environment.

  6. Multispectral Analysis of Surface Wave (MASW) Analysis of Near-Surface Structure at Brady Hot Springs from Active Source and Ambient Noise Using a 8700-meter Distributed Acoustic Sensing (DAS) Array

    NASA Astrophysics Data System (ADS)

    Wang, H. F.; Lord, N. E.; Zeng, X.; Fratta, D.; Feigl, K. L.; Team, P.

    2016-12-01

    The Porotomo research team deployed 8700-meters of Distributed Acoustic Sensing (DAS) cable in a shallow trench on the surface and 400 meters down a borehole at Brady Hot Springs, Nevada in March 2016. The goal of the experiment was to detect changes in geophysical properties associated with hydrologic changes. The DAS cable occupied a natural laboratory of 1500-by-500-by-400-meters overlying a commercial, geothermal field operated by Ormat Technologies. The DAS cable was laid out in three parallel zig-zag lines with line segments approximately 120-meters in length. A large Vibroseis truck (T-Rex) provided the seismic source with a sweep frequency between 5 and 80 Hz over 20 seconds. Over the 15 days of the experiment, the Vibroseis truck re-occupied approximately 250 locations outside and within the array days while changes were made in water reinjection from the power plant into wells in the field. At each source location, one vertical and two orthogonal horizontal modes were excited. Dispersion curves were constructed using MASW and a Vibroseis source location approximately in line with each DAS cable segment or from ambient noise correlation functions. Representative fence diagrams of S-wave profiles were constructed by inverting the dispersion curves obtained for several different line segments.

  7. Further evidence of 777 Ma subduction-related continental arc magmatism in Eastern Dom Feliciano Belt, southern Brazil: The Chácara das Pedras Orthogneiss

    NASA Astrophysics Data System (ADS)

    Koester, E.; Porcher, C. C.; Pimentel, M. M.; Fernandes, L. A. D.; Vignol-Lelarge, M. L.; Oliveira, L. D.; Ramos, R. C.

    2016-07-01

    In this study new SHRIMP U-Pb zircon data for the Chácara das Pedras Gneiss in Porto Alegre, southern Brazil are presented. They represent a small exposure of the crust which was intruded by a large volume of orogenic to anorogenic granitoids at ca. 618-562 m.y. in the Eastern Domain of the Dom Feliciano Belt. The Chácara das Pedras tonalitic orthogneiss has geochemical similarities with subduction-related magmatic rocks of continental arcs. They present high Sr initial ratios (∼0.712), negative ɛNd(t = 777) values (∼-6), TDM varying from 1.8 to 2.0 Ga. The igneous protoliths of these orthogneisses were previously considered to be Paleoproterozoic based on an upper intercept age of discordant zircon analyses. In the present study these orthogneisses were re-sampled and re-analyzed in an attempt to obtain more concordant analytical data. The U-Pb zircon analyses were carried out using the SHRIMP IIe at the Laboratório de Geocronologia de Alta Resolução of the Universidade de São Paulo. The U-Pb concordia age obtained for igneous textural domains of the zircon grains is 777 ± 4 Ma. A few analyses on zircon overgrowths give poorly defined late Cryogenian ages of ca. 650 Ma. Older ages, mostly discordant, were obtained in a few zircon cores, showing an upper intercept age of ca. 1.9 Ga. One sample of the Três Figueiras Granodiorite, which crosscut the orthogneiss in the same outcrop, was also investigated. The zircons of this granodiorite are, however, mostly metamitic, preventing the determination of a reliable age. Some concordant analyses from a few grains define ages ranging in the interval between ca. 603 and 1022 Ma. The youngest (ca. 603 Ma) may represent a maximum age for the granodiorite crystallization. Older ages, with discordance <10%, are of 745, 777, 836 and 1022 Ma. The 777 ± 4 Ma age obtained for the Chácara das Pedras orthogneiss is the first Early Cryogenian magmatic age determined for granitoids in the Porto Alegre region, although

  8. Water Quality-Quantity Evaluation of the Ribeirão das Posses Watershed, Brazil, applying the AgES-W model.

    NASA Astrophysics Data System (ADS)

    Green, T. R.; Cruz, P. P. N. D.; Figueiredo, R. D. O.; Camargo, P. B. D.; Santos, C. P.

    2015-12-01

    Southeastern Brazil is under a period of drought that has impacted the conservation of watersheds and the management of water quality and quantity for agricultural and urban demands. In this context agro-hydrological modeling tools can generate information of water response over time in response to climate and landuse changes. A 12-km2 watershed which has suffered from anthropogenic activities is the Ribeirão das Posses watershed that is located in the extreme south of Minas Gerais State and is a headwater catchment of the Jaguari river, one of the contributing rivers of the Cantareira Reservoir Complex in the state of São Paulo. This watershed had its landscape changed over the last century from native forests to more homogeneous vegetation for pastures and small crops and some forest plantations fragments with eucalyptus. Currently, the Conservative Waters project has planted some small areas with vegetation of native species, especially where there are springs and at the top of the hills, in order to recover degraded areas and improve the hydrogeochemistry in this study basin. In this context, the AgroEcoSystem-Watershed (AgES-W) model is presented to simulate the water movement and storage in agricultural watersheds with different spatial resolutions of land areas or hydrological responses units. The objectives are to evaluate the quality and quantity of water in Ribeirão das Posses Basin using measured data, then simulate these responses in space and time to test the AgES-W model. The period chosen for research was from 2011 to 2015, because the water quality data were collected during this period. The answers that we hope to find out are: How well does the AgES-W model simulate this Brazilian watershed in the tropics? What are the future prospects of the quality and quantity of water in this basin? The results will help to guide hydrological simulations in similar tropical environments in Brazil in this and other agricultural watersheds with AgES-W.

  9. Massa do gás e das estrelas em aglomerados: eficiência da formação estelar

    NASA Astrophysics Data System (ADS)

    Laganá, T. F.; Lima Neto, G. B.

    2003-08-01

    Os aglomerados de galáxias apresentam um interesse especial para a cosmologia observacional. Eles são as maiores estruturas ligadas pela gravitação no Universo e relaxadas na região central. A comparação entre a massa do gás intra-aglomerado (responsável por ~25% da massa total, inferida a partir de observações em raios-X), a massa contida nas estrelas (i.e., nas galáxias) e a massa total (incluindo a matéria escura não bariônica), nos dá informações importantes sobre os processos de formação e evolução de aglomerados. Por exemplo, a razão entre a massa do gás e a massa total é uma medida da fração de bárions no Universo (razão entre a matéria bariônica e matéria escura) e, utilizando a densidade de bárions predita pela nucleosíntese primordial, podemos deduzir a densidade de matéria escura no Universo (cf. White et al. 1993). O objetivo deste trabalho é obter as razões entre as massas do gás, estelar (contida nas galáxias), e a total (massa dinâmica). As massas do gás e total são obtidas a partir das análises fotométrica e espectroscópica em raios-X enquanto que a massa estelar é obtida pela análise fotométrica das galáxias. Esta análise foi aplicada ao aglomerado Abell 496 observado pelo satélite XMM-Newton. A massa contida nas galáxias foi estimada a partir da função de luminosidade obtida por Durret et al. (2002). Para determinar as massas dinâmica e do gás nos precisamos determinar os perfis radiais de densidade e temperatura. Nós apresentaremos aqui estes resultados e suas implicações na eficiência da formação estelar em Abell 496.

  10. Simulation of sampling error of average rainfall rates in space and time by five satellites using radar-AMeDAS composites

    NASA Astrophysics Data System (ADS)

    Iida, Yasuhisa; Okamoto, Ken'ichi; Ushio, Tomoo; Oki, Riko

    2006-01-01

    Sampling error has long been an important issue in satellite-based rainfall measuring mission planning such as for TRMM and GPM (Global Precipitation Measurement), and in evaluating global maps of space-time average rain rate from multi-satellite rainfall data. Sampling errors due to sparse space-time rainfall observations from five currently operated low-earth-orbiting satellites (Aqua, DMSP-F13, F14, F15, TRMM (Tropical Rainfall Measuring Mission)) were evaluated using 3-year radar-AMeDAS composite data around Japan. We simulate realistic observational patterns for the satellite-borne microwave radiometers. Root-mean-square sampling error is expressed as a fraction of true average rain rate. We formulate sampling error as a function of space scale ranging from 0.1° to 5.0°, time scale from 1 to 30 (day), and true average rain rate from 0.001 to 15 (mm/h) for five different combinations of these five satellites.

  11. Dating of fossil human teeth and shells from Toca do Enoque site at Serra das Confusões National Park, Brazil.

    PubMed

    Kinoshita, Angela; Sullasi, Henry L; Asfora, Viviane K; Azevedo, Renata L; Guzzo, Pedro; Guidon, Niede; Figueiredo, Ana Maria G; Khoury, Helen; Pessis, Anne-Marie; Baffa, Oswaldo

    2016-06-07

    This work reports the dating of a fossil human tooth and shell found at the archaeological site Toca do Enoque located in Serra das Confusões National Park (Piauí, Brazil). Many prehistoric paintings have been found at this site. An archaeological excavation unearthed three sepulchers with human skeletons and some shells. Two Brazilian laboratories, in Ribeirão Preto (USP) and Recife (UFPE), independently performed Electron Spin Resonance (ESR) measurements to date the tooth and the shell and obtain the equivalent dose received by each sample. The laboratories determined similar ages for the tooth and the shell (~4.8 kyBP). The results agreed with C-14 dating of the shell and other samples (charcoal) collected in the same sepulcher. Therefore, this work provides a valid inter-comparison of results by two independent ESR-dating laboratories and between two dating methods; i.e., C-14 and ESR, showing the validity of ESR dating for this range of ages.

  12. Using a multi-user desktop-based virtual reality system to recreate the São Miguel das Missões ruins.

    PubMed

    dos Santos, Selan R; Fraga, Letícia S

    2002-10-01

    This paper presents a project initiated back in 1999, in which Virtual Reality is applied in order to create a virtual community over the Internet. The desktop-based multi-user virtual reality system recreates a three-dimensional environment based on photogrammetric maps from the São Miguel das Missões church ruins. The ruins correspond to one of the Jesuit Mission (settlement) which was active in the south of Brazil in the 17th and 18th centuries. It has a great importance to the local region in terms of cultural, historic, and tourist aspects. It has also been inscribed in the UNESCO's world heritage list since 1983. This electronic mock-up allows several interactive operations such as community chats, electronic message exchanging, message boards, walking-through, discussion groups, and embedding of other media such as movies, sound, and html pages. The only requirement necessary to access the community is a web browser powered with any Virtual Reality Modeling Language (VRML) plug-in freely available over the Internet. It is expected that such a solution improves the conservation and dissemination of the Brazilian historic patrimony, congregating history, art, and tourist information in one place on the Internet.

  13. A prospective study of dentoalveolar trauma at the Hospital das Clínicas, São Paulo University Medical School.

    PubMed

    Rezende, Fernanda Mendes do Carmo; Gaujac, Cristiano; Rocha, André Caroli; Peres, Maria Paula Siqueira de Melo

    2007-04-01

    This prospective study evaluated the profile of patients with dentoalveolar trauma assisted at the emergency room of the Oral and Maxillofacial Trauma and Surgery Service at the Hospital das Clínicas, São Paulo University Medical School (Brazil). A prospective study by a questionnaire applied during the first attendance of those patients, in a period of eight months. The collected data were statistically analyzed. It was observed that 4.7% of the patients that sought treatment at the Service had sustained dentoalveolar trauma and among these 74% were male. The most affected individuals were children aged 0 to 5 years and fall was the most prevalent etiologic factor. Avulsion and coronal/crown-root fractures were the most common types of dentoalveolar traumatic injures. As the age increases, the most common etiologic factors are traffic accidents and physical assault. The incidence of dentoalveolar trauma decreased with age and the main etiologic factors in adult patients were traffic accidents and physical assault.

  14. The Serra das Araras Batholith: An example of Ediacaran syntectonic peraluminous granitic magmatism in the southwestern Paraíba do Sul Domain

    NASA Astrophysics Data System (ADS)

    Retamal, Iuri; Machado, Rômulo; Philipp, Ruy Paulo; Lana, Cristiano; Gonçalves, Guilherme O.

    2017-10-01

    The Serra das Araras Batholith (SAB), located at the southwest portion of the Paraíba do Sul Domain, Central Ribeira Belt, is composed of orthogneisses with peraluminous character. Combined LA-ICP-MS U-Pb and Lu-Hf isotopic analyses have been performed in zircon grains for a representative sample (SA-3H) of SAB. Data point to Rhyacian to Orosirian (ca. 2.1-1.8 Ga) inherited zircon cores with positive ɛHf(t) values and Ediacaran U-Pb crystallization age (595 ± 8 Ma). A leucogranite dyke (SA-3D), 15-25 cm thick, which crosscuts SAB and a biotite-hornblende quartz diorite enclave (SA-06) have been analyzed. Crystallization ages for the three samples (ca. 600-590 Ma) and ɛHf(t) values, ranging from -5.6 to -29.4 for Neoproterozoic zircon grains, indicate an Ediacaran crustal magmatism involving mid to lower crust anatexis and the reworking of Paleoproterozoic juvenile and crustal rocks.

  15. [Nutritional status of patients with breast cancer attended in the Mastology Service of Belo Horizonte's Hospital das Clínicas in the state of Minas Gerais, Brazil].

    PubMed

    de Oliveira, Dirce Ribeiro; Carvalho, Erika Simone Coelho; Campos, Liliane Cunha; Leal, José Adalberto; Sampaio, Estela Viana; Cassali, Geovanni Dantas

    2014-05-01

    The scope of this article is to evaluate the nutritional status, body composition and tumor characteristics of 31 patients with breast cancer attended at the Mastology Service of Hospital das Clínicas of the Federal University of Minas Gerais. Dietary data were obtained from the 24-hour dietary recall in the pre-operative state and analyzed by the DietWin Professional 2008 Nutrition Software. Body composition was assessed by bioelectrical impedance analysis. The tumor characterization data were collected from medical records. The mean age of patients was 50.75 ± 14.34 years. Excess body weight was found in 58% and waist circumference greater than 80 cm in 64.5% of patients Excessive consumption of oils and sugars was observed in 90.3% and 83.8%, respectively. Most had low intakes of calcium and vitamins B6, B12 and A. The predominant diagnosis was type II histological grade invasive ductal carcinoma in stage II or III. The prevalence of overweight and inadequate dietary intake demonstrate the need for individualized nutritional guidance and monitoring to improve the prognosis and quality of the life of patients.

  16. [Travelers' vaccinations: experience from the Travelers' Clinic of Hospital das Clínicas, University of São Paulo School of Medicine].

    PubMed

    Chinwa Lo, Simone; Mascheretti, Melissa; Chaves, Tânia do Socorro Souza; Lopes, Marta Heloisa

    2008-01-01

    The profile and vaccination status of travelers seeking pre-travel medical advice at the Travelers' Clinic of Hospital das Clínicas, University of São Paulo School of Medicine, and the vaccines recommended for them, were analyzed in the present study. Among the 445 travelers who were studied, 51% were women, the median age was 33.5 years, 51% were traveling on business and 39.5% were traveling for leisure purposes. The destinations most sought were Africa (47%), Asia (31.7%) and South America (21.4%). Vaccination before traveling was recommended for 385 (86.5%) of the travelers. The main vaccines recommended were against typhoid fever (55.7%), diphtheria-tetanus (54.1%), hepatitis A (46.1%), hepatitis B (44.2%) and yellow fever (24.7%). The pre-travel guidance was shown to be important not only for indicating the vaccines recommended for the trip, but also as an opportunity to update routine vaccinations.

  17. [Voice disorder clinic in the speech therapy outpatient unit at "Hospital das Clínicas da Universidade Federal de Minas Gerais"].

    PubMed

    Menezes, Letícia Neiva de; Behlau, Mara; Gama, Ana Cristina Côrtes; Teixeira, Letícia Caldas

    2011-07-01

    This study set out to describe the profile of the patients with voice complaints and/or alterations who were attended between July 2003 and December 2006 at the speech therapy outpatient unit of "Hospital das Clínicas da Universidade Federal de Minas Gerais." This was analyzed according to age, sex, profession, schooling, origin, treatment performed and factors that interfere in medical care evolution. This was a retrospective study based on the analysis of the recorded data of the individuals according to a specifically prepared Protocol. The results showed that the individuals included in this study were predominantly young women, referred by a specialist from Belo Horizonte, who do not work and also have incomplete elementary school education. Attendance of those patients was on an individual basis, and almost half of them were discharged by the speech therapist. The elderly patients, who have functional or psychogenic dysphonia and a neutral or wheezy type of voice, showed a close correlation with the discharge rate by speech therapist. The younger individuals with organo-functional dysphonia bore a statistical correlation with abandoning treatment. The individuals who eventually abandoned treatment did not bear any correlation with the crossed variables.

  18. Relation among anti-rheumatic drug therapy, CD14(+)CD16(+) blood monocytes and disease activity markers (DAS28 and US7 scores) in rheumatoid arthritis: A pilot study.

    PubMed

    Amoruso, Angela; Sola, Daniele; Rossi, Luca; Obeng, Joyce Afrakoma; Fresu, Luigia Grazia; Sainaghi, Pier Paolo; Pirisi, Mario; Brunelleschi, Sandra

    2016-05-01

    Circulating human monocytes, a functionally and phenotypically heterogeneous population, are emerging as fundamental cell types in rheumatoid arthritis (RA). The aim of this pilot study was to assess the correlation, if any, among anti-rheumatic drug therapy, circulating CD14(+)CD16(+) monocytes and validated clinical scales (e.g., DAS28 score and ultrasonography US7 score) of disease severity in RA. Thirty consecutive RA patients, either naïve or under disease-modifying anti-rheumatic drugs (DMARDs) or biological therapy, and 10 age-matched healthy volunteers, were enrolled. Monocytes were prepared from heparinized blood samples; surface expression of CD14 and CD16 was determined by flow cytometry. RA patients presented a significantly higher percentage of CD14(+)CD16(+) monocytes, as compared to healthy subjects. There was a good correlation between DAS28 clinical score and the ultrasound composite score US7 (r=0.66), as well as between both scores and the percentage of CD14(+)CD16(+) monocytes (r=0.43 and 0.47, respectively). Naïve RA patients had the highest expression (19.2±3.2%) of CD14(+)CD16(+) monocytes and elevated DAS28 score; patients on DMARDs presented a 7-fold increased expression of CD14(+)CD16(+) monocytes, relatively to healthy volunteers (2.1±1.4%), and an intermediate disease severity. The RA patients treated with biological therapy had a low percentage of CD14(+)CD16(+) monocytes (5.1±3.6%; p<0.01 vs naïve and DMARDs groups), similar to the one detected in healthy controls, and reduced US7 and DAS28 scores. Interestingly, for the same DAS28 score, monocytes isolated from RA patients on biological therapy had a lower CD16 expression than patients on DMARDs. Therefore, CD14(+)CD16(+) circulating blood monocytes may represent an appropriate biomarker to assess RA disease activity along with DAS28 and US7 scores. Together, these three parameters may represent a better indicator for evaluating therapy efficacy.

  19. Evaluating the first Brazilian program of payments for environmental services: An approach for optimizing soil conservation using GIS

    NASA Astrophysics Data System (ADS)

    Zolin, C. A.; Folegatti, M. V.; Mingoti, R.; Paulino, J.; Sánchez-Román, R. M.; González, A. M.

    2013-12-01

    Brazil possesses one of the most important water assets in the world, however, the country experiences vast differences among its hydrographic regions. Although Brazil has the largest water reserves in the world, those reserves are not distributed according to the concentration of the population. In addition, the largest portions of these water reserves are not always located where the highest urban concentrations and demands occur, which causes serious problems in maintaining water supply within the country's most populous regions (Zolin et al. 2011). It has become evident that policies aimed at mitigating the growing water resources and water use conflicts in Brazil are crucial. The municipality of Extrema in Minas Gerais state in Brazil pioneered the first Brazilian municipal PES initiative (Conservador das Águas program), based on the relationship between forests and the benefits they provide. This study aimed to assess soil loss in the Posses sub-basin, where the Conservador das Águas program began. Additionally, we aimed to determine the potential that this PES initiative has for soil conservation, as well as to optimize the environmental services provided as a function of forest area size and location. In this sense, considering the prescribed conservation practices, land use situation, and soil cover in the Posses sub-basin, we analyzed the effectiveness of the Conservador das Águas program before and after implementation in relation to reduced soil loss under different land use and soil cover scenarios. We used a geographic information system (GIS) for spatializing and producing different information plans and the Revised Universal Soil Loss Equation (RUSLE) for estimating soil loss. As a result, we found that optimized soil conservation may be obtained by adopting pasture conservation practices. Additionally the expected average soil loss in the Posses sub-basin under conditions of land use and soil cover, before and after implementing the water

  20. Guidelines on management of human infection with the novel virus influenza A (H1N1)--a report from the Hospital das Clínicas of the University of São Paulo.

    PubMed

    Hajjar, Ludhmila Abrahao; Schout, Denise; Galas, Filomena Regina Barbosa Gomes; Uip, David Everson; Levin, Anna Sara Shafferman; Caiaffa Filho, Helio Hehl; Sakane, Pedro Takanori; Suslik, Carlos Alberto; Teixeira, Jose Manoel de Camargo; Bonfa, Eloisa; Barone, Antonio Alci; Martins, Milton de Arruda; Boulos, Marcos; Auler, Jose Otavio Costa

    2009-01-01

    The pandemic novel influenza A (H1N1) infection was considered widespread in Brazil on July, 2009. Since then, 9.249 cases were confirmed in Brazil, most of them concentrated in São Paulo. The Hospital das Clínicas of the University of São Paulo is a reference center for H1N1 cases in São Paulo. The purpose of this review is to analyze the evidence concerning diagnosis, prevention, and treatment of novel influenza A (H1N1) infection. In addition, we propose guidelines for the management of this pandemic emphasizing Hospital das Clínicas "bundles" for the control of the pandemic novel influenza A (H1N1).

  1. The geology of the Morro Velho gold deposit in the Archean Rio das Velhas greenstone belt, Quadrilátero Ferrífero, Brazil

    USGS Publications Warehouse

    Vial, Diogenes Scipioni; DeWitt, Ed; Lobato, Lydia Maria; Thorman, Charles H.

    2007-01-01

    The Morro Velho gold deposit, Quadrilátero Ferrífero region, Minas Gerais, Brazil, is hosted by rocks at the base of the Archean Rio das Velhas greenstone belt. The deposit occurs within a thick carbonaceous phyllite package, containing intercalations of felsic and intermediate volcaniclastic rocks and dolomites. Considering the temporal and spatial association of the deposit with the Rio das Velhas orogeny, and location in close proximity to a major NNW-trending fault zone, it can be classified as an orogenic gold deposit. Hydrothermal activity was characterized by intense enrichment in alteration zones of carbonates, sulfides, chlorite, white mica±biotite, albite and quartz, as described in other Archean lode-type gold ores. Two types of ore occur in the deposit: dark gray quartz veins and sulfide-rich gold orebodies. The sulfide-rich orebodies range from disseminated concentrations of sulfide minerals to massive sulfide bodies. The sulfide assemblage comprises (by volume), on average, 74% pyrrhotite, 17% arsenopyrite, 8% pyrite and 1% chalcopyrite. The orebodies have a long axis parallel to the local stretching lineation, with continuity down the plunge of fold axis for at least 4.8 km. The group of rocks hosting the Morro Velho gold mineralization is locally referred to as lapa seca. These were isoclinally folded and metamorphosed prior to gold mineralization. The lapa seca and the orebodies it hosts are distributed in five main tight folds related to F1 (the best examples are the X, Main and South orebodies, in level 25), which are disrupted by NE- to E-striking shear zones. Textural features indicate that the sulfide mineralization postdated regional peak metamorphism, and that the massive sulfide ore has subsequently been neither metamorphosed nor deformed. Lead isotope ratios indicate a model age of 2.82 ± 0.05 Ga for both sulfide and gold mineralization. The lapa seca are interpreted as the results of a pre-gold alteration process and may be

  2. Imaging Fractures Through Relative Velocity Change Using Ambient Seismic Noise And Distributed Acoustic Sensing (DAS): A SUBTER Pilot Study At Blue Canyon Dome, Socorro NM

    NASA Astrophysics Data System (ADS)

    James, S. R.; Knox, H. A.; Ajo Franklin, J. B.; Johnson, T. C.; Morris, J.; Grubelich, M. C.; King, D. K.

    2016-12-01

    Knowledge of fracture systems, including locations, morphology, and evolution, is critical for groundwater management, contaminant transport, and energy applications such as reservoir development (i.e. tight shale and geothermal) and reservoir management (i.e. carbon sequestration and wastewater injection). It has long been understood that the presence of fractures reduces bulk seismic velocity, with waves traveling perpendicular to fracture planes experiencing the strongest velocity reduction. We present results from seismic interferometry using ambient seismic noise to detect velocity changes following fracture emplacement from two energetic stimulations. Distributed Acoustic Sensing (DAS) using fiber optic cables was used to record seismic arrivals at high spatial resolution ( 3 ft). Cables were grouted in the annulus of four cased monitoring boreholes surrounding the stimulation borehole at a radius of 4 feet. Ambient noise was recorded before and after each stimulation for 12-hour time periods. We used the Python package MSNoise to compute cross-correlations of all near-horizontal (less than 60°) channel pairs between boreholes and calculated the velocity change of each time period relative to initial conditions prior to stimulation. Results show an average velocity decrease of approximately 6% following the first fracturing event. Variations between channel pairs suggest some are more strongly affected than others, which is supported by evaluation of other geophysical data. These results show promise for locating fractures based on spatial variation in velocity changes. Unsurprisingly, results following the second stimulation are generally more scattered. Some velocities are further reduced compared to those after the first stimulation while others show a relative velocity increase. These results are roughly consistent with time-lapse seismic measurements conducted using active sources and classical sensors (e.g. hydrophones). Sandia National Laboratories is

  3. Using the DAS-ELISA Test to Establish an Effective Distance Between Bait Stations for Control of Linepithema humile (Hymenoptera: Formicidae) in Natural Areas.

    PubMed

    Song, Jinbo; Benson, Eric P; Zungoli, Patricia A; Gerard, Patrick; Scott, Simon W

    2015-08-01

    Linepithema humile (Mayr), the Argentine ant, is an invasive pest that has spread throughout the United States and is a problem in natural and managed habitats in South Carolina. Foraging patterns and the effectiveness of liquid baits for control of this pest have been studied in urban areas. However, similar studies have not been conducted in natural areas such as parks, picnic grounds, or campsites. L. humile populations can be large and widespread, making them a major nuisance pest for visitors to these natural areas. The primary objective of this study was to determine an effective distance between bait stations for control of L. humile in a natural area. A double antibody-sandwich enzyme-linked immunosorbent assay (DAS-ELISA) procedure was used to detect individual ants that consumed rabbit immunoglobin (IgG) protein for marking and tracking. In both lab and field conditions, there was a significant difference in the detection of IgG in ants fed protein marker mixed with sugar water compared with ants only fed sugar water. Additional field studies revealed that an individual ant could retain detectable levels of protein marker for 3 d and that an ant feeding on IgG containing bait could be detected over 15 m from the original bait source. Overall, we found that using liquid ant baits, with a placement of 20 m between stations, was effective in reducing L. humile numbers between April to October, 2012 in a natural park area of Lake Greenwood State Park, SC.

  4. Cometas: Das Lendas aos Fatos

    NASA Astrophysics Data System (ADS)

    Voelzke, M. R.

    O descobrimento de cometas, devido ao seu aparecimento espetacular, tem registro nas mais antigas culturas humanas. A primeira referência situa-se no ano de 1095 antes de Cristo [a.C.; HO; HO, 1962]. A quantidade de registros de descobrimentos cometários, principalmente provenientes do território chinês em particular e do oriente em geral, aumentou gradualmente a partir do quarto século depois de Cristo (d.C.). É de origem chinesa a primeira referência ao cometa P/Halley no ano de 240 a.C. [VOELZKE, 1993]. Com o desenvolvimento da astronomia relativamente às técnicas observacionais os descobrimentos bem como as observações cometárias aumentaram sensivelmente a partir do século XVII, sendo que a partir do século XIX um novo incremento ocorreu devido ao emprego da fotografia e a resultante melhora de sensibilidade na observação.

  5. Synthetic generation of spatially high resolution extreme rainfall in Japan using Monte Carlo simulation with AMeDAS analyzed rainfall data sets

    NASA Astrophysics Data System (ADS)

    Haruki, W.; Iseri, Y.; Takegawa, S.; Sasaki, O.; Yoshikawa, S.; Kanae, S.

    2016-12-01

    Natural disasters caused by heavy rainfall occur every year in Japan. Effective countermeasures against such events are important. In 2015, a catastrophic flood occurred in Kinu river basin, which locates in the northern part of Kanto region. The remarkable feature of this flood event was not only in the intensity of rainfall but also in the spatial characteristics of heavy rainfall area. The flood was caused by continuous overlapping of heavy rainfall area over the Kinu river basin, suggesting consideration of spatial extent is quite important to assess impacts of heavy rainfall events. However, the spatial extent of heavy rainfall events cannot be properly measured through rainfall measurement by rain gauges at observation points. On the other hand, rainfall measurements by radar observations provide spatially and temporarily high resolution rainfall data which would be useful to catch the characteristics of heavy rainfall events. For long term effective countermeasure, extreme heavy rainfall scenario considering rainfall area and distribution is required. In this study, a new method for generating extreme heavy rainfall events using Monte Carlo Simulation has been developed in order to produce extreme heavy rainfall scenario. This study used AMeDAS analyzed precipitation data which is high resolution grid precipitation data made by Japan Meteorological Agency. Depth area duration (DAD) analysis has been conducted to extract extreme rainfall events in the past, considering time and spatial scale. In the Monte Carlo Simulation, extreme rainfall event is generated based on events extracted by DAD analysis. Extreme heavy rainfall events are generated in specific region in Japan and the types of generated extreme heavy rainfall events can be changed by varying the parameter. For application of this method, we focused on Kanto region in Japan. As a result, 3000 years rainfall data are generated. 100 -year probable rainfall and return period of flood in Kinu River

  6. Brazil's premier gold province. Part II: geology and genesis of gold deposits in the Archean Rio das Velhas greenstone belt, Quadrilátero Ferrífero

    NASA Astrophysics Data System (ADS)

    Lobato, Lydia; Ribeiro-Rodrigues, Luiz; Vieira, Frederico

    2001-07-01

    Orogenic, gold deposits are hosted by rocks of the Archean Rio das Velhas greenstone belt in the Quadrilátero Ferrífero region, Minas Gerais state, Brazil, one of the major gold provinces in the world. The gold deposits occur at the base of the mafic-ultramafic succession, with the most important orebodies controlled by E-W-striking, strike-slip faults. The main mineralization styles are (1) structurally controlled, sulfide replacement zones in banded iron formation (BIF); (2) disseminated sulfide minerals and gold in hydrothermally altered rocks along shear zones; and (3) auriferous quartz-carbonate-sulfide veins and veinlets in mafic, ultramafic, and felsic volcanic rocks, and also in clastic sedimentary rocks. The most common host rocks for ore are metamorphosed oxide- and carbonate-facies banded iron (± iron-rich metachert) formations (e.g., the Cuiabá, São Bento and Raposos deposits) and the lapa seca unit, which is a local term for intensely carbonatized rock (e.g., the giant Morro Velho mine with >450 t of contained gold). Metabasalts host most of the remaining gold deposits. Mineralogical characteristics and fluid inclusion studies suggest variations in the H2O/CO2 ratio of a low-salinity, near-neutral, reducing, sulfur-bearing, ore fluid. The presence of abundant CH4-rich inclusions is related to reduction of the original H2O-CO2 fluid via interaction with carbonaceous matter in the wallrocks. Oxygen fugacity was close to that of graphite saturation, with variations likely to have been influenced by reaction with the carbonaceous matter. Carbon-rich phyllites and schists, which commonly bound ore-bearing horizons, seem to have played both a physical and chemical role in localizing hydrothermal mineral deposition. Microtextural studies indicate that gold deposition was mainly related to desulfidation reactions, and was paragenetically coeval with precipitation of arsenic-rich iron sulfide minerals. Carbon isotope data are compatible with dissolution of

  7. Diagnostische Präzision der komponentenbasierten vs. der extraktbasierten In-vitro-Diagnostik von Insektengift-Allergien: Auswirkungen auf das klinische Management.

    PubMed

    Seyfarth, Florian; Miguel, Diana; Schliemann, Sibylle; Hipler, Uta-Christina

    2017-05-01

    Die Bestimmung von spezifischen IgE-Antikörpern spielt eine zentrale Bedeutung bei der Diagnostik von Bienen- und Wespengiftallergien. In den letzten Jahren wurden die komponentenbasierte Diagnostik (CRD) eingeführt, die die Bestimmung spezifischer IgE-Antikörper gegen die Allergene Api m 1, Ves v 1, Ves v 5 und Pol d 5 sowie kreuzreaktive Kohlenhydratdeterminanten (CCDs) erlaubt. Hierdurch soll vor allem bei Probanden mit Doppelsensibilisierungen die klinische Relevanz der einzelnen Sensibilisierungen besser beurteilt werden können. Die spezifischen IgE-Antikörper-Bestimmungen an 143 Probanden mit Bienen- und/oder Wespengiftallergie erfolgten mit den extraktbasierten ImmunoCAP®-Allergenen i1 und i3 sowie den ImmunoCAP®-Allergenkomponenten i208-211 und o214 (Api m 1, Ves v 1, Ves v 5, Pol d 5, CCD). Bei Doppelsensibilisierten wurde zusätzlich ein Inhibitionstest durchgeführt. An einem Teilkollektiv der Studienpopulation erfolgten sIgE-Bestimmungen gegen Api m 1, Api m 4, Pol d 5 und Ves v 5 mittels Allergiechip (ISAC®, n  =  44). Die Sensitivität von Ves v 5 bei isolierten Wespengiftallergikern betrug 78,5 %, gemeinsam mit Ves v 1 stieg diese auf 92,3 %. Die Sensitivität von Api m 1 bei isolierten Bienengiftallergikern betrug 25 %. Die komponentenbasierte Diagnostik und Inhibitionstests bei Doppelsensibilisierten lieferten divergente Ergebnisse. Die CRD mittels ISAC®-Allergiechip erbrachte deutliche Unterschiede vor allem im Hinblick auf die Diagnostik von Api m 1 und CCDs. Die CRD bereichert das diagnostische Spektrum, sofern sie nicht allein sondern zusätzlich zu den etablierten Verfahren eingesetzt wird. Sie sollte neben Ves v 5 stets die Bestimmung der IgE-Antikörper gegen Ves v 1 umfassen. © 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

  8. Evaluation of the activity of rheumatoid arthritis in clinical practice. Agreement between self-rated clinimetric evaluation and clinical evaluation with activity indexes: DAS28, CDAI and SDAI.

    PubMed

    Horta-Baas, Gabriel; Pérez Bolde-Hernández, Arturo; Hernández-Cabrera, María Fernanda; Vergara-Sánchez, Imelda; Romero-Figueroa, María Del Socorro

    2017-10-11

    To achieve control of rheumatoid arthritis (RA) it is necessary to be able to evaluate its activity. The American College of Rheumatology (ACR) recommends for this purpose indexes of activity that can be performed by the patient (PAS-II and RAPID-3) and IA including medical evaluation with laboratory studies (DAS28 and SDAI) or without them (CDAI). The objective was to analyze the concordance between self-rated clinimetric evaluation and clinimetric evaluation performed by the physician. Analytical cross-sectional study in 126 patients with RA. The agreement was evaluated through the weighted κ coefficient and the Krippendorff's α coefficient. The PAS-II and RAPID-3 significantly correlated with all variables included in the core set of measures recommended by the ACR/EULAR. The agreement between PAS-II and CDAI-SDAI was good (κ: 0.6, α: 0.61-0.62), and moderate with DAS28-ESR (κ: 0.53, α: 0.56). The concordance between RAPID-3 and CDAI-SDAI was moderate (κ: 0.55-0.57, α: 0.50-0.51), and moderate with DAS28-ESR (κ: 0.55, α: 0.53). When categorizing the activity in remission/low activity vs. moderate/severe activity, the agreement was greater with the PAS-II (0.59 vs. 0.34; P=.012). The good concordance between PAS-II and SDAI supports their use in clinical practice, especially if biomarkers of inflammation or the possibility of joint count are not available. However, in order to recommend its routine application in clinical practice, it is necessary to perform longitudinal studies that assess its responsiveness. Copyright © 2017 Elsevier España, S.L.U. All rights reserved.

  9. Epidemiology of human infection with the novel virus influenza A (H1N1) in the Hospital das Clínicas, São Paulo, Brazil--June-September 2009.

    PubMed

    Schout, Denise; Hajjar, Ludhmila Abrahao; Galas, Filomena Regina Barbosa Gomes; Uip, David Everson; Levin, Anna Sara Shafferman; Caiaffa Filho, Helio Hehl; Sakane, Pedro Takanori; Suslik, Carlos Alberto; Teixeira, Jose Manoel de Camargo; Bonfa, Eloisa; Barone, Antonio Alci; Martins, Milton de Arruda; Boulos, Marcos; Auler, Jose Otavio Costa

    2009-01-01

    The pandemic novel influenza A (H1N1) infection was considered widespread in Brazil on July 16, 2009. Since then, 46,810 cases of acute respiratory syndrome have been reported in Brazil, most of them concentrated in São Paulo. Through September 16, we have confirmed 9,249 cases of novel influenza A H1N1in Brazil, including 699 deaths. The mortality rate observed in Brazil is 0.47/100,000 inhabitants and varies according to region. In this period, São Paulo registered 3733 cases (40.3% of the total) of novel influenza A (H1N1) infection and 327 deaths, reflecting a mortality rate of 0.79/100,000 inhabitants. The Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC) is a reference center for H1N1 cases in São Paulo. During the winter of 2009, 472 patients in this hospital were diagnosed with H1N1 infection; of these, 210 were admitted, and 16 died. To control this pandemic and to provide adequate care for these patients, the Hospital das Clínicas implemented "bundles" including prevention strategies, an epidemiologic surveillance service, availability of fast diagnosis, antiviral treatment and training of staff. The purpose of this manuscript is to describe the epidemiologic features of novel human influenza A (H1N1) infection in the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo during the winter period of the 2009 pandemic.

  10. Método numérico das diferenças finitas no domínio do tempo aplicado a ondas Alfvén em plasma astrofísico

    NASA Astrophysics Data System (ADS)

    Dos Santos, L. C.; Kintopp, J. A.; Jatenco-Pereira, V.; Opher, R.

    2003-08-01

    Ondas Alfvén em plasma astrofísico têm sido objeto de intenso estudo nas últimas décadas pelo fato de apresentarem papel importante em muitas áreas de pesquisa na astrofísica. Particularmente são importantes no mecanismo de aquecimento da coroa solar; em ventos estelares; em jatos galácticos e extragalácticos; em discos protoestelares, etc. A formulação para diferenças finitas no domínio do tempo (FDTD), aplicada a plasma magnetizado é desenvolvida para estudo das propriedades de ondas Alfvén em três dimensões (3D-FDTD). O método é aplicado inicialmente a um plasma homogêneo e isotérmico imerso em uma região com campo magnético externo B0, que sofre uma pequena perturbação. Uma vez gerada a onda, esta perturbação é retirada e, então analisamos a evolução temporal das ondas, bem como a forma de seu amortecimento.

  11. Assessment of the validity of the 28-joint disease activity score using erythrocyte sedimentation rate (DAS28-ESR) as a disease activity index of rheumatoid arthritis in the efficacy evaluation of 24-week treatment with tocilizumab: subanalysis of the SATORI study.

    PubMed

    Nishimoto, Norihiro; Takagi, Nobuhiro

    2010-12-01

    As tocilizumab (TCZ) greatly inhibits inflammatory markers, methods of evaluating rheumatoid arthritis (RA) disease activity that include inflammatory markers may overestimate the effect of TCZ treatment. We have evaluated the impact of inflammatory markers on the efficacy of TCZ by comparing the efficacy indicated by the 28-joint disease activity score using erythrocyte sedimentation rate (DAS28-ESR) with that indicated by the clinical and simplified disease activity indexes (CDAI and SDAI, respectively) and the American College of Rheumatology (ACR) core set criteria in a double-blind study of TCZ-the SATORI study. The Spearman correlation coefficient between DAS28-ESR and CDAI was comparable between that at week 24 and that at baseline [correlation coefficient at baseline and week 24 was 0.823 (p < 0.0001) and 0.818 (p < 0.0001), respectively]. A large difference between the DAS28 remission rate and CDAI remission rate was observed at week 24. However, these results are comparable to those of a previous study conducted with non-TCZ-treated patients. Moreover, the same results were obtained in the comparison between the DAS28-ESR and SDAI, even though the SDAI includes an inflammatory parameter as a component. These results confirm that the DAS28-ESR has a validity comparable to that of other methods in terms of evaluating the RA treatment efficacy of TCZ, despite its strong inflammatory marker-inhibiting effects.

  12. [Esophageal perforation in children: a review of one pediatric surgery institution's experience (16 years)].

    PubMed

    Vieira, Elizabete; Cabral, Maria João; Gonçalves, Mroslava

    2013-01-01

    Introdução: O estudo teve por objetivo avaliar a experiência do nosso Serviço no tratamento das perfurações esofágicas. Material e Métodos: Análise retrospetiva de nove casos ocorridos entre 1 de Janeiro de 1996 e 31 de Dezembro de 2011. Destes casos, sete ocorreram após ingestão acidental de corpos estranhos e em dois tratou-se de lesões iatrogénicas após dilatação esofágica: por estenose péptica num caso e no outro por estenose da anastomose esofágica término-terminal de uma criança operada por atrésia do esófago. Resultados: Em 78% dos casos a abordagem inicial foi médica, com encerramento comprovado da perfuração em média ao fim de 20 dias; 22% dos doentes (dois casos) foram submetidos a cirurgia sem sucesso, acabando um deles por curar sem sequelas com pausa alimentar e terapêutica médica; no outro caso verificou-se necessidade de realizar posteriormente uma esofagocoloplastia. Na nossa série não se registou mortalidade. Discussão: A perfuração esofágica é uma das lesões mais graves do trato alimentar, continuando a ser devastadora, e, de difícil diagnóstico e tratamento. O reconhecimento desta complicação é fundamental para o seu tratamento com sucesso. Conclusões: O atraso do diagnóstico está associado a uma mortalidade que pode oscilar entre os 20 e 40%.

  13. Vernetztes Lernen: Eine Unterrichtseinheit mit Heinrich von Kleists Erzahlung "Das Erdbeben in Chili" und Crista Wolfs Roman "Kein Ort. Nirgends" (Networked Learning: An Instructional Unit with Heinrich von Kleist's Story "The Earthquake in Chile" and Christa Wolf's Novel "No Place, No Where").

    ERIC Educational Resources Information Center

    Eidecker, Martina Elisabeth

    1999-01-01

    Presents an instructional model, using Kleist's story "Das Erdbeben in Chili" and Christa Wolf's novel Kei Ort. Nirgends" as a basis. The model clearly distinguishes itself from quantitative models and mediates solid literary knowledge through an inductive approach. Learning takes place in a multidimensional space that makes possible multiple…

  14. Mapping health assessment questionnaire disability index (HAQ-DI) score, pain visual analog scale (VAS), and disease activity score in 28 joints (DAS28) onto the EuroQol-5D (EQ-5D) utility score with the KORean Observational study Network for Arthritis (KORONA) registry data.

    PubMed

    Kim, Hye-Lin; Kim, Dam; Jang, Eun Jin; Lee, Min-Young; Song, Hyun Jin; Park, Sun-Young; Cho, Soo-Kyung; Sung, Yoon-Kyoung; Choi, Chan-Bum; Won, Soyoung; Bang, So-Young; Cha, Hoon-Suk; Choe, Jung-Yoon; Chung, Won Tae; Hong, Seung-Jae; Jun, Jae-Bum; Kim, Jinseok; Kim, Seong-Kyu; Kim, Tae-Hwan; Kim, Tae-Jong; Koh, Eunmi; Lee, Hwajeong; Lee, Hye-Soon; Lee, Jisoo; Lee, Shin-Seok; Lee, Sung Won; Park, Sung-Hoon; Shim, Seung-Cheol; Yoo, Dae-Hyun; Yoon, Bo Young; Bae, Sang-Cheol; Lee, Eui-Kyung

    2016-04-01

    The aim of this study was to estimate the mapping model for EuroQol-5D (EQ-5D) utility values using the health assessment questionnaire disability index (HAQ-DI), pain visual analog scale (VAS), and disease activity score in 28 joints (DAS28) in a large, nationwide cohort of rheumatoid arthritis (RA) patients in Korea. The KORean Observational study Network for Arthritis (KORONA) registry data on 3557 patients with RA were used. Data were randomly divided into a modeling set (80 % of the data) and a validation set (20 % of the data). The ordinary least squares (OLS), Tobit, and two-part model methods were employed to construct a model to map to the EQ-5D index. Using a combination of HAQ-DI, pain VAS, and DAS28, four model versions were examined. To evaluate the predictive accuracy of the models, the root-mean-square error (RMSE) and mean absolute error (MAE) were calculated using the validation dataset. A model that included HAQ-DI, pain VAS, and DAS28 produced the highest adjusted R (2) as well as the lowest Akaike information criterion, RMSE, and MAE, regardless of the statistical methods used in modeling set. The mapping equation of the OLS method is given as EQ-5D = 0.95-0.21 × HAQ-DI-0.24 × pain VAS/100-0.01 × DAS28 (adjusted R (2) = 57.6 %, RMSE = 0.1654 and MAE = 0.1222). Also in the validation set, the RMSE and MAE were shown to be the smallest. The model with HAQ-DI, pain VAS, and DAS28 showed the best performance, and this mapping model enabled the estimation of an EQ-5D value for RA patients in whom utility values have not been measured.

  15. Cometa Hyakutake (C/1996 B2): análise do gás e características físicas das partículas de poeira

    NASA Astrophysics Data System (ADS)

    Sanzovo, G. C.; de Almeida, A. A.; Boczko, R.

    2003-08-01

    A completa caracterização e compreensão do núcleo de um cometa novo é de fundamental importância para a elucidação dos processos físicos e químicos atuantes na época da formação do Sistema Solar. O Cometa Hyakutake, conjuntamente com o Cometa Hale-Bopp representam os objetos mais brilhantes que visitaram o Sistema Solar Interno nos últimos 20 anos. Neste Trabalho, nós aplicamos o Método Semi-Empírico das Magnitudes Visuais (MSEMV) à aproximadamente 4000 dados observacionais que correlacionam a magnitude visual absoluta com a distância heliocêntrica para o Cometa Hyakutake nas fases pré- e pós-periélicas. Como produto da aplicação desse método, conseguimos caracterizar dimensionalmente seu núcleo e área ativa efetiva. As taxas de produção dos radicais CN, C2 e C3, obtidos a partir de dados disponíveis na literatura, revelam que, além de muito brilhante, o Hyakutake é um cometa "normal" no sentido de Cochran (1986). Desse modo, deduzimos as taxas de perdas de água (em moléculas/s) a partir da análise de sua magnitude visual aparente, e as convertemos em taxas de perdas de gás (em g/s), despreendido pelo nucleo cometário. Com o auxílio do modelo fotométrico clássico da poeira, realizamos uma análise sistemática e uniforme dessa componente cometária, a partir dos fluxos observacionais no contínuo, para os comprimentos de onda 365,0 e 484,5 nm, assumindo que esses fluxos são o resultado da radiação solar espalhada por grãos de partículas micrométricos presentes na coma. Com isso, pudemos obter as taxas de produção (em g/s), cores (relativas à cor neutra solar), e as dimensões efetivas médias das partículas de poeira, bem como as razões poeira-gás.

  16. Association between rheumatoid arthritis disease activity, progression of functional limitation and long-term risk of orthopaedic surgery: combined analysis of two prospective cohorts supports EULAR treat to target DAS thresholds

    PubMed Central

    Nikiphorou, Elena; Norton, Sam; Young, Adam; Carpenter, Lewis; Dixey, Josh; Walsh, David Andrew; Kiely, Patrick

    2016-01-01

    Objectives To examine the association between disease activity in early rheumatoid arthritis (RA), functional limitation and long-term orthopaedic episodes. Methods Health Assessment Questionnaire (HAQ) disability scores were collected from two longitudinal early RA inception cohorts in routine care; Early Rheumatoid Arthritis Study and Early Rheumatoid Arthritis Network from 1986 to 2012. The incidence of major and intermediate orthopaedic surgical episodes over 25 years was collected from national data sets. Disease activity was categorised by mean disease activity score (DAS28) annually between years 1 and 5; remission (RDAS≤2.6), low (LDAS>2.6–3.2), low-moderate (LMDAS≥3.2–4.19), high-moderate (HMDAS 4.2–5.1) and high (HDAS>5.1). Results Data from 2045 patients were analysed. Patients in RDAS showed no HAQ progression over 5 years, whereas there was a significant relationship between rising DAS28 category and HAQ at 1 year, and the rate of HAQ progression between years 1 and 5. During 27 986 person-years follow-up, 392 intermediate and 591 major surgeries were observed. Compared with the RDAS category, there was a significantly increased cumulative incidence of intermediate surgery in HDAS (OR 2.59 CI 1.49 to 4.52) and HMDAS (OR 1.8 CI 1.05 to 3.11) categories, and for major surgery in HDAS (OR 2.48 CI 1.5 to 4.11), HMDAS (OR 2.16 CI 1.32 to 3.52) and LMDAS (OR 2.07 CI 1.28 to 3.33) categories. There was no significant difference in HAQ progression or orthopaedic episodes between RDAS and LDAS categories. Conclusions There is an association between disease activity and both poor function and long-term orthopaedic episodes. This illustrates the far from benign consequences of persistent moderate disease activity, and supports European League Against Rheumatism treat to target recommendations to secure low disease activity or remission in all patients. PMID:26979104

  17. Association between rheumatoid arthritis disease activity, progression of functional limitation and long-term risk of orthopaedic surgery: combined analysis of two prospective cohorts supports EULAR treat to target DAS thresholds.

    PubMed

    Nikiphorou, Elena; Norton, Sam; Young, Adam; Carpenter, Lewis; Dixey, Josh; Walsh, David Andrew; Kiely, Patrick

    2016-12-01

    To examine the association between disease activity in early rheumatoid arthritis (RA), functional limitation and long-term orthopaedic episodes. Health Assessment Questionnaire (HAQ) disability scores were collected from two longitudinal early RA inception cohorts in routine care; Early Rheumatoid Arthritis Study and Early Rheumatoid Arthritis Network from 1986 to 2012. The incidence of major and intermediate orthopaedic surgical episodes over 25 years was collected from national data sets. Disease activity was categorised by mean disease activity score (DAS28) annually between years 1 and 5; remission (RDAS≤2.6), low (LDAS>2.6-3.2), low-moderate (LMDAS≥3.2-4.19), high-moderate (HMDAS 4.2-5.1) and high (HDAS>5.1). Data from 2045 patients were analysed. Patients in RDAS showed no HAQ progression over 5 years, whereas there was a significant relationship between rising DAS28 category and HAQ at 1 year, and the rate of HAQ progression between years 1 and 5. During 27 986 person-years follow-up, 392 intermediate and 591 major surgeries were observed. Compared with the RDAS category, there was a significantly increased cumulative incidence of intermediate surgery in HDAS (OR 2.59 CI 1.49 to 4.52) and HMDAS (OR 1.8 CI 1.05 to 3.11) categories, and for major surgery in HDAS (OR 2.48 CI 1.5 to 4.11), HMDAS (OR 2.16 CI 1.32 to 3.52) and LMDAS (OR 2.07 CI 1.28 to 3.33) categories. There was no significant difference in HAQ progression or orthopaedic episodes between RDAS and LDAS categories. There is an association between disease activity and both poor function and long-term orthopaedic episodes. This illustrates the far from benign consequences of persistent moderate disease activity, and supports European League Against Rheumatism treat to target recommendations to secure low disease activity or remission in all patients. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  18. Composition of grain and forage from insect-protected and herbicide-tolerant corn, MON 89034 × TC1507 × MON 88017 × DAS-59122-7 (SmartStax), is equivalent to that of conventional corn (Zea mays L.).

    PubMed

    Lundry, Denise R; Burns, J Austin; Nemeth, Margaret A; Riordan, Susan G

    2013-02-27

    Monsanto Company and Dow AgroSciences LLC have developed the combined-trait corn product MON 89034 × TC1507 × MON 88017 × DAS-59122-7 (SmartStax, a registered trademark of Monsanto Technology LLC). The combination of four biotechnology-derived events into a single corn product (stacking) through conventional breeding provides broad protection against lepidopteran and corn rootworm insect pests as well as tolerance to the glyphosate and glufosinate-ammonium herbicide families. The purpose of the work described here was to assess whether the nutrient, antinutrient, and secondary metabolite levels in grain and forage tissues of the combined-trait product are comparable to those in conventional corn. Compositional analyses were conducted on grain and forage from SmartStax, a near-isogenic conventional corn hybrid (XE6001), and 14 conventional reference hybrids, grown at multiple locations across the United States. No statistically significant differences between SmartStax and conventional corn were observed for the 8 components analyzed in forage and for 46 of the 52 components analyzed in grain. The six significant differences observed in grain components (p < 0.05) were assessed in context of the natural variability for that component. These results demonstrate that the stacked product, SmartStax, produced through conventional breeding of four single-event products containing eight proteins, is compositionally equivalent to conventional corn, as previously demonstrated for the single-event products.

  19. Lactic acid microbiota identification in water, raw milk, endogenous starter culture, and fresh Minas artisanal cheese from the Campo das Vertentes region of Brazil during the dry and rainy seasons.

    PubMed

    Castro, R D; Oliveira, L G; Sant'Anna, F M; Luiz, L M P; Sandes, S H C; Silva, C I F; Silva, A M; Nunes, A C; Penna, C F A M; Souza, M R

    2016-08-01

    Minas artisanal cheese, produced in the Campo das Vertentes region of Brazil, is made from raw milk and endogenous starter cultures. Although this cheese is of great historical and socioeconomic importance, little information is available about its microbiological and physical-chemical qualities, or about its beneficial microbiota. This work was aimed at evaluating the qualities of the cheese and the components used for its production, comparing samples collected during the dry and rainy seasons. We also conducted molecular identification and isolated 50 samples of lactic acid bacteria from cheese (n=21), water (n=3), raw milk (n=9), and endogenous starter culture (n=17). The microbiological quality of the cheese, water, raw milk, and endogenous starter culture was lower during the rainy period, given the higher counts of coagulase-positive Staphylococcus and total and thermotolerant coliforms. Enterococcus faecalis was the lactic acid bacteria isolated most frequently (42.86%) in cheese samples, followed by Lactococcus lactis (28.57%) and Lactobacillus plantarum (14.29%). Lactobacillus brevis (5.88%), Enterococcus pseudoavium (5.88%), Enterococcus durans (5.88%), and Aerococcus viridans (5.88%) were isolated from endogenous starter cultures and are described for the first time in the literature. The lactic acid bacteria identified in the analyzed cheeses may inhibit undesirable microbiota and contribute to the safety and flavor of the cheese, but this needs to be evaluated in future research.

  20. Comparison of grain from corn rootworm resistant transgenic DAS-59122-7 maize with non-transgenic maize grain in a 90-day feeding study in Sprague-Dawley rats.

    PubMed

    He, X Y; Huang, K L; Li, X; Qin, W; Delaney, B; Luo, Y B

    2008-06-01

    DAS-59122-7 (59122) is a transgenic maize (Zea mays L.) that contains genes encoding Cry34Ab1 and Cry35Ab1 proteins from Bacillus thuringiensis Berliner strain 149B1 and phosphinothricin acetyltransferase (PAT) protein from Streptomyces viridochromogenes. Expression of these proteins in planta confers resistance to corn rootworms and other Coleopteran parasites and tolerance to herbicides containing glufosinate ammonium, respectively. In the current study, processed flours from 59122 maize grain or its near isogenic control line (091) were used at two concentrations (50% and 70% wt/wt) to produce diets that were fed to rats for 90 days in accordance with Chinese toxicology guidelines (GB15193.13-2003). A commercial AIN93G diet was used as an additional negative control. No significant differences in body weight and feed utilization were observed between rats consuming diets formulated with 59122 and 091 Control corn. Statistical differences (p<0.05) were observed in certain hematology and serum chemistry response variables between rats consuming diets formulated with 59122 or 091 Control flour compared to AIN93G diet. However, the mean value of these response variables in the 59122 groups were not statistically different from those observed in diets formulated with corresponding high and low concentrations of the flour from the 091 Control maize grain. Therefore, the statistical differences were considered to be related to consumption of diets containing high concentrations of maize flour (compared to AIN93G diets) regardless of source rather than to consumption of flour from 59122 maize grain. The results from this study demonstrated that 59122 maize grain is as safe as non-transgenic maize grain.

  1. Das deutsche Adverbialsystem (The German Adverbial System)

    ERIC Educational Resources Information Center

    Droescher, W. O.

    1974-01-01

    Describes the surface structure of German adverbs proceeding from the standpoint of dependence-valence grammar. On the basis of their meaning, adverbs are classified as modal, temporal and locational. (Text is in German.) (IFS/WGA)

  2. Kanban - der Weg ist das Ziel

    NASA Astrophysics Data System (ADS)

    Aull, Florian; Berlak, Joachim; Dickmann, Eva; Dickmann, Philipp; Fischäder, Holm; Gerlach, Joachim; Henneberg, Jens; Kapalla, Klaus; Kress, Oliver; Kuttler, Robert; Schneider, Herfried M.; Schürle, Philipp; Stellpflug, Franz-Josef; Wannenwetsch, Ralph; Wulz, Johannes; Zäh, Michael F.

    Wenn man aktuell Produktionsbereiche in Deutschland und Europa besucht, fallen im Zusammenhang mit modernen Produktionsmethoden immer öfter die Begriffe Kanban (jap. Karte, Signal) und Pull-Produktion, und dies nicht ohne Stolz, da diese mit dem schillernden Vorbild des Toyota Produktionssystems in Zusammenhang stehen. Tatsächlich ist Kanban ein integraler Bestandteil moderner Produktionssysteme. Blickt man aber im Rahmen von Prozessanalysen hinter die Fassaden", d. h. in die tägliche Praxis der Arbeitsprozesse, wird man schnell desillusioniert - die viel gepriesenen klassischen Kanban-Regeln werden im Tagesgeschäft nicht eingehalten.

  3. Physikgeschichte Das Rätsel bleibt

    NASA Astrophysics Data System (ADS)

    Hoffmann, Dieter

    2002-05-01

    Die jüngst erfolgte Veröffentlichung von Dokumenten aus dem Privatarchiv der Familie Bohr [1] über den geheimnisumwitterten Besuch von Werner Heisenberg in Kopenhagen im September 1941 hat in den deutschen Medien große Resonanz gefunden [2]. Tatsächlich verraten uns die jetzt veröffentlichten Dokumente sehr viel mehr über die Zeit ihres Entstehens als über den Besuch selbst.

  4. Das Gluck des Kindes (The Child's Happiness).

    ERIC Educational Resources Information Center

    Fuhr, Thomas

    2002-01-01

    Examines the pedagogical discourse on the child's happiness, the structure of happiness, empirical findings on a child's happiness. Addresses the problems of research on children's needs. Concludes that happiness also includes feelings of joy or sorrow and that pedagogical judgments should take into account these feelings. (CAJ)

  5. Das Gluck des Lehrers (The Teacher's Happiness).

    ERIC Educational Resources Information Center

    Higgins, Christopher

    2002-01-01

    Argues that the ethics of teaching concerns the relationship between the teaching and the good life. Uses Bernard Williams' ethics/morality distinction. Connects the question of "why teach?" with the question "how should I live?" Asks why the practice of teaching is worth it in terms of self growth and monetary gains. (CAJ)

  6. Internationale Schulreformtendenzen und das Problem der Lehrerausbildung

    NASA Astrophysics Data System (ADS)

    Kupisiewicz, Czeslaw

    1982-09-01

    The main theme of this article is that the socio-economic and educational changes which have occurred in industrialized countries in the past 20 to 25 years necessitate a thorough reform of the present system of teacher education. The first group of such changes includes the information explosion, greater occupational mobility, the growing significance and increasing role of the sciences, the development of the mass media, higher educational aspirations, technical development, the acceleration of the psycho-physical development of children and youth, and the injurious effects of the uncontrolled development of the constantly changing civilisation (deterioration of the human environment, diseases caused by the effects of civilisation, etc.). In the face of these changes, teachers must not remain indifferent and teacher education systems have to take them into account. Within the second group of changes influencing the content and methods of teacher education, the most important is the generalisation of education at the pre-school, primary and secondary school levels and also at the university level. As a result, education in many types of school and at ever higher levels has lost the elitist character it still had, not so long ago, and has become a mass activity. This has considerably affected teachers' work and, necessarily, also the work of the teacher education systems. In present-day schools it is necessary to emphasize not only the transmission of knowledge of the `know that' type, as was done in the past, but also problem-solving, independent individual and group work, etc., which will enable children and young people to acquire `know-how' and `know-why'. This must also be reflected in teacher education. In order to adapt the teacher education systems to the requirements of the changing society, a reform of the goals, contents and methods of the system will have to be prepared and implemented as a prerequisite and starting point for a global reform of the entire education system.

  7. Determinação da massa de júpiter a partir das órbitas de seus satélites: um experimento didático

    NASA Astrophysics Data System (ADS)

    Schlickmann, M. S.; Saito, R. K.; Becker, D. A.; Rezende, M. F., Jr.; Cid Fernandes, R.

    2003-08-01

    Este trabalho apresenta o roteiro piloto de uma prática observacional em astronomia, junto com os primeiros resultados obtidos nesta fase de implementacão. O projeto, que será executado em duas etapas, visa introduzir noções de Astronomia a alunos do Ensino Médio e iniciantes nos cursos de Física. O experimento consiste em medir as órbitas dos satélites Galileanos e, a partir da análise dos dados coletados, verificar a validade da Lei das órbitas de Kepler, determinando a massa do planeta Júpiter. Em uma primeira etapa, as observações serão feitas utilizando um telescópio Meade LX200 10" e câmera CCD para obter uma seqüência de imagens do planeta, que possibilitará medir o movimento de seus satélites. A segunda etapa terá início a partir do funcionamento do telescópio em modo robótico, com a possibilidade de observações via internet por instituições de ensino. Para o desenvolvimento deste experimento foram inicialmente coletadas várias imagens de Júpiter obtidas com os instrumentos citados acima. Estas imagens serviram como base para confecção dos roteiros para a experiência no nível médio e superior. Os roteiros serão inicialmente apresentados em uma home-page. Nela também se buscará uma contextualização histórica da experiência bem como o estabelecimento de relações com professores e alunos, propostas metodológicas e a disponibilização dos programas computacionais necessários para a utilização "on-line" pelos usuários. O projeto conta com apoio da Fundação VITAE.

  8. Importance of land use update during the calibration period and simulation of water balance response to land use change in the upper Rio das Mortes Catchment (Cerrado Biome, Central-Western Brazil)

    NASA Astrophysics Data System (ADS)

    Lamparter, Gabriele; Kovacs, Kristof; Nobrega, Rodolfo; Gerold, Gerhard

    2015-04-01

    Changes in the hydrological balance and following degradation of the water ecosystem services due to large scale land use changes are reported from agricultural frontiers all over the world. Traditionally, hydrological models including vegetation and land use as a part of the hydrological cycle use a fixed distribution of land use for the calibration period. We believe that a meaningful calibration - especially when investigating the effects of land use change on hydrology - demands the inclusion of land use change during the calibration period into the calibration procedure. The SWAT (Soil and Water Assessment Tool) model is a process-based, semi-distributed model calculating the different components of the water balance. The model bases on the definition of hydrological response units (HRUs) which are based on soil, vegetation and slope distribution. It specifically emphasises the role of land use and land management on the water balance. The Central-Western region of Brazil is one of the leading agricultural frontiers, which experienced rapid and radical deforestation and agricultural intensification in the last 40 years (from natural Cerrado savannah to cattle grazing to intensive corn and soya cropland). The land use history of the upper Rio das Mortes catchment (with 17500 km²) is reasonably well documented since the 1970th. At the same time there are almost continuous climate and runoff data available for the period between 1988 and 2011. Therefore, the work presented here shows the model calibration and validation of the SWAT model with the land use update function for three different periods (1988 to 1998, 1998 to 2007 and 2007 to 2011) in comparison with the same calibration periods using a steady state land use distribution. The use of the land use update function allows a clearer identification which changes in the discharge are due to climatic variability and which are due to changes in the vegetation cover. With land use update included into the

  9. Rotação do jato em DG tau próximo à região de sua formação: análise comparativa das velocidades radiais simuladas e observadas

    NASA Astrophysics Data System (ADS)

    Cerqueira, A. H.; de Gouveia dal Pino, E. M.

    2003-08-01

    Os modelos magneto-centrífugos utilizados para explicar a formação dos jatos Herbig-Haro assumem a presença de um disco de acresção em rotação kepleriana na base de lançamento do jato. Neste cenário, o jato transmite a informação da rotação do disco para regiões distantes da fonte central, além da superfície de Alfvén, na região de colimação inicial do jato. Recentemente, Bacciotti et al. (2002, ApJ, 537, L49) obtiveram pela primeira vez uma evidência observacional de rotação em um jato HH, o jato em DG Tau, em regiões próximas da fonte central, compatível (qualitativa e quantitativamente) com o esperado a partir dos modelos magneto-centrífugos para a produção e colimação inicial de jatos HH. No presente trabalho, apresentamos mapas de velocidade radial, obtidos através de simulações numéricas tri-dimensionais SPH, para um jato com características semelhantes ao jato em DG Tau, objetivando uma comparação com os mapas de velocidade radiais obtidos por Bacciotti et al.. Nossos resultados, embora preliminares, indicam que a inclusão de efeitos como a precessão, evidenciada em DG Tau (Dougados et al. 2000, A&A, 357, L61) devem ser levadas em consideração na análise da presença de rotação não só em DG Tau mas em qualquer sistema, com o uso das velocidades radias observadas. A ausência de um grau elevado de simetria axial (quebrada, por exemplo, pela precessão do eixo do jato; ou pela presença de uma superfície interna de trabalho, ou seja, um bow shock interno), implica também em uma maior complexidade nos mapas, com conseqüências relevantes para suas interpretações.

  10. Performance of lactating dairy cows fed corn as whole plant silage and grain produced from genetically modified corn containing event DAS-59122-7 compared to a nontransgenic, near-isogenic control.

    PubMed

    Brouk, M J; Cvetkovic, B; Rice, D W; Smith, B L; Hinds, M A; Owens, F N; Iiams, C; Sauber, T E

    2011-04-01

    The nutritional equivalency of grain plus whole plant silage from genetically modified corn plants containing the DAS-59122-7 (59122) event expressing the Cry34Ab1 and Cry35Ab1 proteins to grain and silage from a near-isogenic corn hybrid without this trait (control) was assessed using lactating dairy cows. Corn plants with event 59122 are resistant to western corn rootworm and tolerant to the herbicide active ingredient glufosinate-ammonium. Effects on feed intake, milk production, and milk composition were determined. The 59122 grain and the control grain were produced in 2005 from isolated plots in Richland, Iowa. Whole plant corn silage for the 59122 and control treatments were grown in isolated plots at the Kansas State University Dairy Center and ensiled in Ag-Bags. Thirty lactating Holstein cows blocked by lactation number, day of lactation, and previous energy-corrected milk production were used in a switchback design. All cows were fed diets that contained 22.7% grain plus 21.3% whole plant silage from either the 59122 or the control hybrid, in addition to 21% wet corn gluten feed, 12.3% protein mix, 8.0% whole cottonseed, and 14.7% alfalfa hay. Each period of the switchback trial included 2 wk for diet adjustment followed by 4 wk for data and sample collection. Milk samples (a.m. and p.m.) collected from 2 consecutive milkings of each collection wk were analyzed for fat, protein, lactose, solids-not-fat, milk urea nitrogen, and somatic cell count. Percentages of milk fat, protein, lactose, and solids-not-fat were not affected by dietary treatment. Yields of milk, 4% fat-corrected milk, energy-corrected milk, solids-corrected milk, and the concentrations and yields of milk fat, milk protein, milk solids, and milk lactose were not significantly different between treatments. Efficiencies of milk, fat-corrected milk, energy-corrected milk, and solids-corrected milk production also were not different when cows were fed crops from 59122 than when they were fed

  11. Screening for pulmonary tuberculosis in Teresópolis, RJ, Brazil: the search for respiratory symptomatic patients in emergency service of "Hospital das Clínicas de Teresópolis Costantino Ottaviano, Fundação Educacional Serra dos Orgãos".

    PubMed

    Siqueira-Batista, Rodrigo; Gomes, Andréia Patrícia; Bisaglia, Joana B; Borlot, Paulo Estevão W; D'avila Junior, Heraldo X; Faria, Carolina Gonçalves P P de; Braga, Bernardo D; Bezerra, Tiago S; Cedrola, Juan Pedro V; Almeida, Guilherme C; Couto, Lílian S; Nacif, Marcelo; Crivano, Elvira

    2005-01-01

    The aim of the present study was to investigate the detection percentage of tuberculosis among patients that are respiratory symptomatic (TB suspects). In this work, we present the preliminary results of research carried out at "Hospital das Clínicas de Teresópolis Costantino Ottaviano da Fundacao Educacional Serra dos Orgãos (FESO)" from November 2003 to April 2004. Among the 40 respiratory symptomatic individuals identified and referred to the Tuberculosis Control Program in Teresópolis , two (5.0%) were characterized as smear-positive. These results confirm reports in the literature and underscore the need for and importance of this strategy.

  12. Proving the Orbits of the Galilean Moons Through Astrophotography. (Spanish Title: Comprobando Las Órbitas de Las Lunas Galileanas a Través de la Astrofotografía.) Evidenciando as Órbitas das Luas Galileanas Atravéd da Astrofotografia

    NASA Astrophysics Data System (ADS)

    Iachel, Gustavo

    2009-12-01

    An activity related to the observation of the Galilean moons and to amateur astrophotography is presented in this work. Through the reading of excerpts of the book Sidereus Nuncius (Sidereal Messenger), by Galileo, it is possible to trace a methodology to observe the planet and its natural satellites and, with the aid of the astrophotography, to analyze the field recordings. Moreover, it is possible to compare the images obtained after plotting the relative positions of these moons to prove their orbits. This activity can be conducted by teachers, students and amateur astronomers, in order to develop their capabilities of observation of astronomical phenomena. Se presenta en este trabajo una actividad relacionada a la observación de las lunas Galileanas y a la astrofotografía amateur. A través de la lectura de tramos de la obra Sidereus Nuncius (El Mensajero Sideral) de Galileo, es posible trazar una metodología para la observación del planeta y de sus satélites naturales y, con el auxilio de la astrofotografía, analizar las anotaciones de campo. Además, es posible comparar las imágenes obtenidas con el gráfico de las posiciones relativas de estas lunas para comprobar sus órbitas. Esa actividad puede ser realizada por maestros, estudiantes y astrónomos amateurs, de forma a desarrollar sus capacidades de observación de los fenómenos astronómicos. Uma atividade relacionada à observação das luas Galileanas e à astrofotografia amadora é apresentada neste trabalho. Através da leitura de trechos da obra Sidereus Nuncius (Mensageiro Sideral), de Galileu, é possível traçar uma metodologia para a observação do planeta e de seus satélites naturais e, com o auxílio da astrofotografia, analisar as anotações de campo. Além disso, é possível comparar as imagens obtidas com o gráfico das posições relativas destas luas para evidenciar suas órbitas. Essa atividade pode ser realizada por professores, estudantes e astrônomos amadores, de forma a

  13. [Carotid atherosclerosis and white matter hypodensities: a controversial relationship].

    PubMed

    Félix-Morais, Ricardo; Sargento-Freitas, João; Silva, Fernando; Cordeiro, Gustavo; Nunes, César; Ribeiro, Joana; Cordeiro, Miguel; Moura, Cristina; Cunha, Luis

    2014-01-01

    Introdução: As hipodensidades da substância branca de provável etiologia vascular, são uma causa importante de morbilidade, condicionando deterioração cognitiva. No entanto, numerosas dúvidas persistem quanto à sua fisiopatologia. O objectivo deste estudo é clarificar o papel da aterosclerose carotídea e outros factores de risco vascular no desenvolvimento das hipodensidades da substância branca de provável etiologia vascular.Material e Métodos: Realizou-se uma avaliação imagiológica, por tomografia computadorizada crânio-encefálica e ecografia carotídea, com menos de um mês de intervalo. Procedeu-se à recolha de informação sobre os factores de risco vascular. Determinámos associações independentes entre hipodensidades da substância branca de provável etiologia vascular, espessura da íntima média carotídea, estenose carotídea ateromatosa e factores de risco vascular.Resultados: Foram incluídos 472 doentes, idade média de 67,32 (DP: 14.75), 274 (58,1%) sexo masculino. Os preditores independentes da hipodensidades da substância branca de provável etiologia vascular foram: idade (OR: 1,067, 95% IC: 1,049 – 1,086, p < 0,001) e a hipertensão (OR: 1,726, 95% IC: 1,097 – 2,715, p = 0,018). Não foi encontrada uma associação entre a espessura da intima média carotídea (OR: 2,613, 95% IC: 0,886 – 7,708, p = 0,082) ou grau de estenose carotídea (OR: 1,021, 95% IC: 0,785 – 1,328, p = 0,877) e hipodensidades da substância branca de provável etiologia vascular.Discussão: Dos diversos factores de risco analisados, apenas a idade e hipertensão se associaram de forma independente às hipodensidades da substância branca de provável etiologia vascular. Não foi encontrada uma relação entre a aterosclerose extracraniana, expressa pela espessura do complexo intima-média ou grau de estenose, com o desenvolvimento de hipodensidades da substância branca de provável etiologia vascular. Sendo a aterosclerose um fen

  14. Retrospective analysis of a case series of patients with traumatic injuries to the craniocervical junction.

    PubMed

    Esteves, Luiz Adriano; Joaquim, Andrei Fernandes; Tedeschi, Helder

    2016-01-01

    To evaluate the correlation between the treatment, the characteristics of the lesions and the clinical outcome of patients with traumatic injuries to the craniocervical junction. This was a retrospective study of patients treated conservatively or surgically between 2010 and 2013 with complete data sets. We analyzed 37 patients, 73% were men with mean age of 41.7 years. Of these, 32% were submitted to initial surgical treatment and 68% received conservative treatment. Seven (29%) underwent surgery subsequently. In the surgical group, there were seven cases of odontoid type II fractures, two cases of fracture of posterior elements of the axis, one case of C1-C2 dislocation with associated fractured C2, one case of occipitocervical dislocation, and one case of combined C1 and C2 fractures, and facet dislocation. Only one patient had neurological déficit that improved after treatment. Two surgical complications were seen: a liquoric fistula and one surgical wound infection (reaproached). In the group treated conservatively, odontoid fractures (eight cases) and fractures of the posterior elements of C2 (five cases) were more frequent. In two cases, in addition to the injuries of the craniocervical junction, there were fractures in other segments of the spine. None of the patients who underwent conservative treatment presented neurological deterioration. Although injuries of craniocervical junction are relatively rare, they usually involve fractures of the odontoid and the posterior elements of the axis. Our results recommend early surgical treatment for type II odontoid fractures and ligament injuries, the conservative treatment for other injuries. Avaliar a correlação entre o tratamento, as características das lesões e o resultado clínico em pacientes com lesões traumáticas na junção craniocervical. Estudo retrospectivo de pacientes maiores de 18 anos tratados de forma conservadora ou cirúrgica, entre 2010 e 2013. Foram analisados 37 pacientes, 73% eram do

  15. Astronomy in High School: Using a Mini-Planetarium to Understand Details of the Apparent Movement of Stars. (Spanish Title: Astronomía en la Escuela Secundaria: Comprendiendo los Detalles del Movimiento Aparente de Las Estrellas con un Miniplanetario.) Astronomia no Ensino Médio: Compreendendo Detalhes do Movimento Aparente das Estrelas com um Miniplanetário

    NASA Astrophysics Data System (ADS)

    dos Santos Leão, Demetrius

    2013-07-01

    en la comprensión de estas cuestiones y demostraron un gran interés por esta metodología. O objetivo deste artigo é apresentar parte dos resultados obtidos com a intervenção feita como projeto da dissertação de mestrado do autor, que consistiu no desenvolvimento de um conjunto de aulas de Astronomia, com alunos do 1º Ano do Ensino Médio de uma escola da rede privada do Distrito Federal (Brasília, Brasil), empregando como recurso principal um material didático chamado miniplanetário (MP). Utilizando como pressuposto teórico norteador dessas aulas as ideias de contextualização e dialogicidade de Paulo Freire, foi proposta aos estudantes a montagem e utilização desse recurso em uma sessão de planetário. Durante o projeto, enfatizaram-se assuntos como a trajetória aparente das estrelas para o céu de Brasília, a localização dos pontos cardeais a partir da constelação do Cruzeiro do Sul, as cores das estrelas e as estrelas vistas de uma determinada localidade. Apurou-se que os alunos apresentaram melhoria na compreensão desses assuntos, bem como demonstraram expressiva empolgação com essa metodologia desenvolvida.

  16. Excising das All: Evolving Maxwell waves beyond Scri

    NASA Technical Reports Server (NTRS)

    vanMeter, James R.; Fiske, David R.; Misner, Charles W.

    2006-01-01

    We study the numerical propagation of waves through future null infinity in a conformally compactified spacetime. We introduce an artificial cosmological constant, which allows us some control over the causal structure near null infinity. We exploit this freedom to ensure that all light cones are tilted outward in a region near null infinity, which allows us to impose excision-style boundary conditions in our finite difference code. In this preliminary study we consider electromagnetic waves propagating in a static, conformally compactified spacetime.

  17. Das Deutschlandspiegelvideo (The View-of-Germany-Videos).

    ERIC Educational Resources Information Center

    Pentecost, Gislind E.

    1993-01-01

    Describes View-of-Germany-Videos, published by the Goethe Institute. The videos are authentic, entertaining, and very versatile in usefulness. In addition they are short, thus easily incorporated into a lesson plan, and free of charge, making them accessible to any educational establishment. (AB)

  18. Erfolgsfaktoren von Lehrstellenmarketing in der dualen berufsbildung: das beispiel Schweiz

    NASA Astrophysics Data System (ADS)

    Sager, Fritz

    2006-09-01

    SUCCESS FACTORS OF APPRENTICESHIP MARKETING IN A SYSTEM OF DUAL VOCATIONAL TRAINING: THE CASE OF SWITZERLAND - The dual system of vocational training, utilizing both company training and vocational school, is generally acknowledged to be a successful model, but a decreasing number of trainee posts in Switzerland poses a crisis for the approach. One strategy for overcoming the problem involves offering incentives for companies to create new trainee posts. The present study explores the necessary conditions for successfully influencing the number of trainee posts through apprenticeship marketing. A comparision of qualitative case studies of six marketing projects demonstrates that while context, in the sense of basic structural conditions and political sensibility for the problematic, plays a role in the success of a project, what is central is above all the form of the trainee-post marketing project itself. This has to do with the behaviour of the actors involved as well as the choice of the mode of governance and project organization. The latter has to do with making available requisite technical and personal resources, coordination on the part of the project direction, and giving those responsible the necessary room to act in implementing the project.

  19. Demokratie lernen am gymnasium: das projekt "schule als staat"

    NASA Astrophysics Data System (ADS)

    Sajak, Clauß Peter

    2002-09-01

    (Learning Democracy in High School: the "School as State" Project) - The disquieting social developments in the German Federal Republic are leading to intense discussions about the possibilities of instilling values and democratic attitudes within the context of secondary education. The interdisciplinary educational project "School as State" has been running for some time in various schools in Baden-Württemberg. This article describes the goals and processes of this project and examines the didactic approaches from which it emerged.

  20. Der Forschungsflughafen und das Institut fuer Luft- und Raumfahrtsysteme

    DTIC Science & Technology

    2007-11-02

    Forschungsflughafen Aerodata Deutsches Zentrum für Luft- und Raumfahrt DLR VW Air Services TU Braunschweig Luftfahrt-Bundesamt LBA Deutscher Aeroclub... Aerodata - Weltmarktführer für Flight Inspection Systeme Flight Inspection - Flugvermessung

  1. Identifizierung der Eintragsquellen von Antibiotika in das Grundwasser viehstarker Regionen

    NASA Astrophysics Data System (ADS)

    Hannappel, Stephan; Köpp, Claudia; Zühlke, Sebastian; Balzer, Frederike; Schulz, Dietrich

    2016-11-01

    Only few sulfonamide antibiotics were detected in near-surface groundwater in areas with a high stocking rate in northwestern Germany. Intensive sampling with a high resolution in time and space was applied in order to illuminate the findings. As some pharmaceuticals can be of both human and animal origin, they may enter the environment via application of manure/digestate to arable land or via domestic waste water. In addition to existing monitoring wells, non-permanent wells were sampled to obtain information regarding pathways into the ground water. Interviews with farmers and chemical analyses show that application of manure leads to low concentrations (<100 ng/l) of Sulfadimidin and Sulfadiazin in most of the investigated samples. Sulfamethoxazol was found above 100 ng/l and likely originated from sewage of nearby small scale wastewater treatment plants. Sulfamethoxazole and its main metabolite could be detected within the plants; additionally, the sewage tracer acesulfam-K was detected in the groundwater.

  2. Das Deutschlandspiegelvideo (The View-of-Germany-Videos).

    ERIC Educational Resources Information Center

    Pentecost, Gislind E.

    1993-01-01

    Describes View-of-Germany-Videos, published by the Goethe Institute. The videos are authentic, entertaining, and very versatile in usefulness. In addition they are short, thus easily incorporated into a lesson plan, and free of charge, making them accessible to any educational establishment. (AB)

  3. Entwicklungsarbeit am Spurendetektor fur das CDF Experiment am Tevatron

    SciTech Connect

    Hartmann, Frank

    2000-02-01

    Silicon, the element, which revolutionized the development of electronics, is known as an important and multiusable material, dominating todays electronic technology. It's properties are well investigated and today well known. Silicon is used in solar cells, computers and telecommunications. Since the Sixties semiconductors have been used as particle detectors. Initially they were operated in fixed- target experiments as calorimeters and as detectors with a high precision track reconstruction. Since the Eighties they are widely used in collider experiments as silicon microstrip or silicon pixel detectors near the primary vertex. Silicon sensors have a very good intrinsic energy resolution: for every 3.6 eV released by a particle crossing the medium, one electron-hole pair is produced. Compared to 30 eV required to ionize a gas molecule in a gaseous detector, one gets 10 times the number of particles. The average energy loss and high ionized particle number with 390 e V / μm ~ 108 (electron - hole pairs)/ μm is effectively high due to the high density of silicon. These detectors allow a high precision reconstruction of tracks, primary and secondary vertices, which are especially important for b flavour tagging. The Tevatron and its detectors are being upgraded for the next data taking run starting in 2001 (RUN II). The Collider Detector at Fermilab (CDF) [2] for the upcoming Run II and its upgraded components are described in chapter 2. The main upgrade project is the design and construction of a completely new inner tracking system.

  4. Facetten der Reurbanisierung. Das Beispiel Mönchengladbach

    NASA Astrophysics Data System (ADS)

    Hamm, Rüdiger; Jäger, Angelika; Keggenhoff, Katja

    2017-06-01

    In the light of an increasing importance of the discussion on reurbanization, the article analyses the current socioeconomical and structural development of the city of Moenchengladbach. City development processes are marked by a high degree of dynamic individualization - an increasing number of cities have achieved a stage of reurbanization, whereas others have not completeley reached that stage of urban renewal. An analysis of Moenchengladbach indicates that quantative aspects of reurbanization are fulfilled, whereas qualitative reurbanisation processes as an increasing attractiveness, urban revaluation, and gentrification of innercity areas remain a future potential.

  5. Das andere Zuhause. Ortsbezüge hochqualifizierter Migranten

    NASA Astrophysics Data System (ADS)

    Plöger, Jörg; Günther, Florian

    2016-12-01

    Cities are increasingly addressing high-skilled migrants. Our contribution examines the factors that shape how this group relates to places and why cities provide different conditions for this. We draw on empirical data from an explorative case study with highly qualified migrants in the university city of Münster. First, we look at the place ties at the new place of residence and thereby focus on their local social networks and their sense of belonging. Second, we turn to the place-specific characteristics, in particular the role of "connections" and "urban opportunity structures". Based on our findings we discuss how urban policy-making may influence the place attachment of this desired group.

  6. Das Isotopenthermometer im ewigen Eis: Mechanismen globaler Klimaschwankungen

    NASA Astrophysics Data System (ADS)

    Stauffer, Bernhard

    Die Analysen von zwei Bohrkernen im grönländischen Eis haben unser Wissen über Klimaschwankungen und deren mögliche Ursachen stark erweitert. Die 18 O-Messreihe zeigt, dass der Übergang von der letzten Eiszeit zur Nacheiszeit in drastischen Sprüngen erfolgte und dass es auch während der Eiszeit schnelle, drastische Klimaänderungen, so genannte Dansgaard-Oeschger -Ereignisse gab. Basierend auf der heute gültigen Beziehung zwischen mittlerer Jahrestemperatur und 18 O-Wert nahm man an, dass der Temperaturanstieg zwischen Eiszeitmaximum und Nacheiszeit rund 12°C und zu Beginn eines Dansgaard-Oeschge-Ereignisses rund 8°C betrugen. Neue Kalibrationsmethoden haben gezeigt, dass die Temperatursprünge praktisch doppelt so groß waren, wie die mit der Dansgaard-Beziehung ermittelten. Erstaunlich sind vor allem die schnellen Temperaturanstiege. Ein Temperaturanstieg von mehr als 10°C e folgte oft in wenigen Jahrzehnten. Die Methanmessreihe ergab, dass die Dansgaard-Oeschger -Ereignisse kein auf Grönland beschränktes Phänomen sind. Es sind Klimaschwankungen von globaler Bedeutung. Die zeitliche Synchronisation von Messreihen auf Grönland und der Antarktis mithilfe von Methanvariationen ergab, dass einer abrupten Erwärmung in Grönland oft eine Erwärmung in der Antarktis vorausging. Von zwei Kernbohrungen im Rahmen des European Project for Ice Coring in Antarctica erwartet man vor allem neue Erkenntnisse über Klimawechselwirkungen zwischen den beiden Hemisphären und über die Ursachen der Variationen von Treibhausgaskonzentrationen parallel zu globalen Klimaschwankungen.

  7. Das modale Hilfsverb "will" (The Modal Auxiliary Verb "Will")

    ERIC Educational Resources Information Center

    Kunsmann, Peter W.

    1975-01-01

    That "will" and "shall" are modal, not temporal, verbs is shown by their syntactic similarity to the modals and by the fact that they follow the same transformational rules as the modals. This example demonstrates the usefulness of transformational grammar in explaining grammatical relationships to students. (Text is in…

  8. High School Student's Alternative Conceptions About the Phenomenon of the Formation of the Moon Phases. (Spanish Title: Concepciones Alternativas de Alumnos de Educación Media Sobre el Fenómeno de Formación de las Fases de La Luna.) Concepções Alternativas de Alunos do Ensino Médio Sobre o Fenômeno de Formação das Fases da Lua

    NASA Astrophysics Data System (ADS)

    Iachel, Gustavo; Langhi, Rodolfo; Fernandes Scalvi, Rosa Maria

    2008-07-01

    Forty students, at ages between 14 and 18 years old, from three schools in Bauru city, were questioned about their alternative conceptions concerning the phenomenon of formation of the Moon Phases. It was observed that some of the pupils confound the phenomenon of the formation of the Moon Phases with the phenomenon of the formation of the lunar eclipses, others are unaware of the reason of the phenomenon, they present incoherent alternative conceptions of the reality or incomplete conceptions. The results found here are aimed at the teachers of Elementary Education and can be used as a subsidy for future development of new pedagogical methods. Cuarenta estudiantes, con edad entre 14 y 18 años, pertenecientes a tres escuelas de la ciudad de Bauru, fueron cuestionados sobre sus concepciones alternativas acerca del fenómeno de la formación de las fases de la Luna. Fue observado que algunos alumnos confunden el fenómeno de formación de las fases de la Luna con el fenómeno de formación de los eclipses lunares, otros desconocen el motivo delfenómeno, presentan concepciones alternativas incoherentes con la realidad o bien presentan concepciones incompletas. Los resultados aquí encontrados son destinados a los profesores de la Enseñanza Básica y podrán ser usados como ayuda para el futuro desarrollo de nuevos métodos pedagógicos. Quarenta estudantes, com idades entre 14 e 18 anos, pertencentes a três escolas da cidade de Bauru, foram questionados sobre suas concepções alternativas acerca do fenômeno de formação das fases da Lua. Foi observado que alguns dos alunos confundem o fenômeno da formação das fases da Lua com o fenômeno da formação dos eclipses lunares, outros desconhecem o motivo do fenômeno, apresentam concepções alternativas incoerentes com a realidade ou então concepções incompletas. Os resultados aqui encontrados são destinados aos professores do Ensino Básico e poderão ser usados como subsídio parafuturo desenvolvimento de

  9. [Accidental Dural Puncture and Post-dural Puncture Headache in the Obstetric Population: Eight Years of Experience].

    PubMed

    Antunes, Maria Vaz; Moreira, Adriano; Sampaio, Catarina; Faria, Aida

    2016-04-01

    Introdução: A punção acidental da dura é uma importante complicação da anestesia regional e a cefaleia pós-punção continua a ser causa de morbilidade na população obstétrica. O objetivo do nosso estudo foi calcular a incidência de punção acidental e cefaleia pós-punção no nosso Centro Hospitalar e avaliar a sua abordagem entre os anestesiologistas obstétricos. Material e Métodos: Realizámos uma auditoria retrospetiva, entre janeiro de 2007 e dezembro de 2014. Revimos as folhas de registo das doentes em que ocorreu punção inadvertida da dura ou cefaleia pós-punção. Excluímos as doentes submetidas a bloqueio subaracnoideu. Utilizámos o SPSS 22.0 no tratamento estatístico dos dados. Resultados: Obtivémos 18 497 bloqueios neuro-axiais e 58 punções acidentais da dura (0,3%). Após punção detetada, em 71,4% o cateter epidural foi re-posicionado e 21,4% tiveram cateteres intra-tecais. Quarenta e cinco (77,6%) desenvolveram cefaleia e a instituição de medidas profiláticas ocorreu em 76,1%. O tratamento conservador foi efetuado em todas as doentes. O blood patch epidural foi realizado em 32,8% com um sucesso de 84,2%. Discussão: A incidência de cefaleia pós-punção não está relacionada com o tipo de parto ou a inserção do cateter intra-tecal. A re-colocação do cateter epidural mantém-se a abordagem de eleição após punção. A instituição de medidas profiláticas é uma prática comum, apesar do baixo grau de eficácia. Realizámos blood patch epidural após falência do tratamento conservador. Conclusão: A incidência de punção inadvertida e cefaleia pós-punção foi semelhante à da literatura. Apesar de ser uma complicação comum, existe falta de consenso na sua abordagem.

  10. Memories of Astronomy Education in Brazil: Clippings from the Discourses of Interviewed Researchers on the Subject. (Spanish Title: Memorias de la Educación en Astronomía en Brasil: Recortes de los Discursos de Investigadores Entrevistados Acerca del Tema ) Memórias da Educação em Astronomia no Brasil: Recortes a Partir das Falas de Pesquisadores Entrevistados sobre o Tema

    NASA Astrophysics Data System (ADS)

    Iachel, Gustavo; Nardi, Roberto

    2014-12-01

    This paper presents a historical retrospective concerning data from a research in Astronomy Education in Brazil, after 1973. It was organized on the basis of the speech analysis of national researchers considered references in this field by their peers. Furthermore, it was elaborated on the basis of other studies from the areas of Science Education, Physics and Astronomy. This historical overview was developed in order to facilitate understanding of the contexts in which the interviewed researchers have developed professionally. Moreover, we attempted to recover the memory of the growing field of research in Astronomy Education in the country. We believe that the history presented can help those trying to understand the past in an attempt to resolve current and future demands. Se presenta en este artículo una retrospectiva histórica referente a datos provenientes de la investigación en enseñanza de la astronomía en el Brasil, después de 1973, organizada sobre la base del análisis de los discursos de los investigadores nacionales considerados referencias en este campo, y también en la lectura de las publicaciones en las áreas de Enseñanza de las Ciencias, Física y Astronomía. Este repaso histórico se desarrolló con el fin de facilitar la comprensión de los contextos en los que los investigadores entrevistados se han desarrollado profesionalmente. Por otra parte, se intentó recuperar la memoria del creciente campo de la investigación en Educación en Astronomía en el país. Creemos que el relato presentado puede contribuir a quien trata de comprender el pasado, en un intento de resolver las demandas actuales y futuras. Relata-se neste artigo uma retrospectiva histórica referente a dados provenientes de pesquisa em Educação em Astronomia no país, pós 1973, organizada com base na análise das falas de pesquisadores considerados referências nacionais nesse campo, como também na leitura de publicações das áreas de ensino de Ciências, F

  11. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... scallop vessel issued an Occasional limited access permit when fishing under the Sea Scallop Area Access... Atlantic sea scallop limited access permit, the vessel owner signs out of the VMS program for a minimum..., or while the vessel was not at sea. (e) VMS notifications—(1) VMS installation notification. (i)...

  12. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... scallop vessel issued an Occasional limited access permit when fishing under the Sea Scallop Area Access... Atlantic sea scallop limited access permit, the vessel owner signs out of the VMS program for a minimum..., or while the vessel was not at sea. (e) VMS notifications—(1) VMS installation notification. (i)...

  13. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... scallop vessel issued an Occasional limited access permit when fishing under the Sea Scallop Area Access... Atlantic sea scallop limited access permit, the vessel owner signs out of the VMS program for a minimum..., or while the vessel was not at sea. (e) VMS notifications—(1) VMS installation notification. (i)...

  14. Kepler, Galilei, the telescope and the consequences. (German Title: Kepler, Galilei, das Fernrohr und die Folgen)

    NASA Astrophysics Data System (ADS)

    Gaulke, Karsten; Hamel, Jürgen

    The papers of this volume are dedicated to Johannes Kepler, the astronomy of his time, and the consequences of his researches. They deal with the reception on the Copernican system of the world at the court of landgrave William IV in Kassel and the use of astronomy at a princely court in the 16th century, exemplified by the Kassel residence. Two contributions discuss a text fragment in Kepler's Astronomia Nova and the dimensions of the geo- and heliocentric systems of the world in Kepler's Mysterium Cosmographicum. Other contributions deal with mathematical aspects un Kepler's exchange of letters, the biography of Kepler's discussion partner Ph. Feselius, as well as the early reception of the Tabulae Rudolphinae in the calendar literature, telescopes in Kepler's time, Chr. Scheiner's optical theory of the eye, and finally in the continuation of the heliocentric world system by Otto von Guericke's natural philosophy and science. In conclusion, the documents of the planned call of Kepler to Rostock university, as well as the first publication of a recently found, hitherto unknown letter by Kepler.

  15. Story II: Kommerzialisierung innovativer Technologien - das Beispiel der WoodWelding SA

    NASA Astrophysics Data System (ADS)

    Mayer, Jörg; Plasonig, Gerhard

    Technologische Innovation war und ist der prinzipielle Grund der Erhöhung der Wertschöpfung von Produkten, Produktionsprozessen und Dienstleistungen in zumindest den letzten 100 Jahren. Die BoneWelding® Technologie ist - wie viele andere Plattformtechnologien auch - im universitären Umfeld entstanden. Um den Prozess, den die Gründer des Unternehmens WoodWelding SA erfolgreich durchlaufen haben, besser zu verstehen, folgen ein paar grundlegenden Ausführungen, die zu erfolgreicher Technologieentwicklung, -transfer und Unternehmens-Start-up führten.

  16. Das Studium: Vom Start zum Ziel: Lei(d)tfaden für Studierende

    NASA Astrophysics Data System (ADS)

    Messing, Barbara

    Wer studieren will, hat viele Fragen und muss viele Entscheidungen treffen. Dieser Leitfaden hilft, eine Wahl zutreffen, sich an der Hochschule zurecht zu finden und Hürden rechtzeitig zu erkennen und zu bewältigen. Es geht um Fragen wie: Wer unterstützt mich finanziell? Studentenwohnheim oder WG? Was bringt eine Vorlesung? Wie komme ich an eine Abschlussarbeit - und wie schreibe ich sie? Weitere Themen sind: Struktur der Hochschule, Lebensabschnitt Studium, Motivation beim Lernen, Zeitmanagement im Studium, Recherchieren und Lesen, Verstehen und Entwickeln, Mathematik im Studium, Vorträge halten und Prüfungen bestehen.

  17. Das baden-württembergische Innovationssystem im Wandel:. Akteure vor neuen Herausforderungen

    NASA Astrophysics Data System (ADS)

    Stahlecker, Thomas; Zenker, Andrea

    2017-09-01

    Recently, new forms of innovation, new actors and actor constellations can be observed, especially in "mature" innovation systems like Baden-Wuerttemberg, that are flanked by new instruments of innovation support. Against the backdrop of an evolved innovation system heuristics, this paper outlines these new developments in Baden-Wuerttemberg. It uses examples to describe characteristic innovation actors, actors from the research landscape, education and the intermediary function of mediators, social actors as well as the aspect of innovation financing and to reveal current tendencies and trends. It becomes clear that the innovation system in Baden-Wuerttemberg has continuously evolved and become more differentiated. Its industries' research efforts and modernization activities as well as innovation-friendly policies contribute to the adaptability of the system and are major influencing factors for the ongoing success of the innovation system. This is supplemented by diverse innovations at the level of actors, institutions and measures. The question concerns the governance and capacity of this complex system given dynamic changing global circumstances.

  18. The Electron Microscope as an Aid in Colloid Research (Das Elektronenmikroskop als Hilfsmittel der Kolloidforschung),

    DTIC Science & Technology

    1978-03-09

    selected as an example. Because gold dispersions in borax glass are easier to prepare than those in silicate glass, we studied a borax pyrosol. The...mean gold particle size in borax melts prepared in various ways have been calculated by EHRINGHAUS and WINTGEN (7) from the gold concentration and the...number of particles estimated with the ultramicroscope. For example , in a light blue gold borax glass with 0.0127. gold content they find a mean part

  19. Kindern das Wort Geben ein interkulturell-kreativer Arbeitsansatz, aufgezeigt an der Arbeit mit tibetischen Migrantenkindern

    NASA Astrophysics Data System (ADS)

    Rabkin, Gabriele

    2001-03-01

    Promotion of creativity in the cause of peace and international understanding is a fundamental part of the UNESCO programme to build a culture of peace. A central aspect of this undertaking consists in encouraging children to express themselves freely on this subject in writing and art. An approach has been developed to stimulate children's creativity and to create a link between creative expression and education for intercultural understanding. This article is divided into two parts. The first explains the pedagogical and psychological concepts behind this approach. The second describes a project in which these concepts were applied. It focuses on a minority dispersed over many parts of the world, namely children of Tibetan families. The description is accompanied by commentaries of the Fourteenth Dalai Lama, arising from a personal audience granted to the author in 1999.

  20. Vehicle DAS Considerations for the Iron Gorget Threats: Analysis, Modelling and Comments to Operations Researchers

    DTIC Science & Technology

    2007-02-01

    10 Figure 8. RPG -7 radiance image ... imaging infrared, to detect and home in on targets. – BAT (Brilliant Anti-Tank) is an acoustic and infrared guided submunition that searches, tracks and...CO2 2.056×10−1 H2 2.076×10−1 14 DRDC Valcartier TM 2004–356 Figure 8. A radiance image from the RPG -7, the image is 0.4 m wide and 0.2 m high. DRDC

  1. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Point Gong Buoy “1AHP” 42°42.0′ 70°37.5′ 12. Connecting reference point 42°40′ 70°30′ 13. Whistle Buoy...′ 71°32.1′ 34. Shinnecock Inlet Lighted Whistle Buoy “SH” 40°49.0′ 72°28.6′ 35. Scotland Horn Buoy “S”, off Sandy Hook (NJ) 40°26.5′ 73°55.0′ 36. Barnegat Lighted Gong Buoy “2” 39°45.5′ 73°59.5′ 37. A...

  2. Das Gymnasium Zwischen Tradition und Modernen Bildungsanspruchen (The Gymnasium between Tradition and Modern Educational Requirements).

    ERIC Educational Resources Information Center

    Heller, Kurt A.

    2003-01-01

    Provides brief history of the German Gymnasium as a traditional European secondary school system with a preparatory function for higher education. Reviews the main goals of the gymnasium. Asks what role the gymnasium plays as a learning environment for gifted students. Discusses the politico-educational consequences and demands on the gymnasium.…

  3. Das Ende der Nacht [The End of the Night (2nd enlarged ed.)

    NASA Astrophysics Data System (ADS)

    Posch, Thomas; Hölker, Franz; Uhlmann, Thomas; Freyhoff, Anja

    2013-09-01

    We provide provide an overview of the history of lighting and of the problems arising from artificial lighting. The book covers the following topics: A brief history of light (ch. 1); night and light in cultural history (ch. 2); light pollution in central Europe (ch. 3); Moths and artificial lights (ch. 4); Artificial lighting and birds (ch. 5); Ocean turtles as victims of beach lighting (ch. 6); Moon light as a zeitgeber for the marine fauna (ch. 7); the influence of artificial light at night on freshwater ecology (ch. 8); artificial light and human health (ch. 9); the loss of the night in a 24 hours society (ch. 10).

  4. A Data Acquisition System (DAS) for marine and ecological research from aerospace technology

    NASA Technical Reports Server (NTRS)

    Johnson, R. A.

    1972-01-01

    The efforts of researchers at Mississippi State University to utilize space-age technology in the development of a self-contained, portable data acquisition system for use in marine and ecological research are presented. The compact, lightweight data acquisition system is capable of recording 14 variables in its present configuration and is suitable for use in either a boat, pickup truck, or light aircraft. This system will provide the acquisition of reliable data on the structure of the environment and the effect of man-made and natural activities on the observed phenomenon. Utilizing both self-contained analog recording and a telemetry transmitter for real-time digital readout and recording, the prototype system has undergone extensive testing.

  5. Consideracoes Extemporaneas acerca das Metodologias Qualitativas (Extemporaneous Considerations about Qualitative Methodology).

    ERIC Educational Resources Information Center

    Pucci, Bruno

    2000-01-01

    Considers the differences between quantitative and qualitative research. Cites some essays by Adorno when he was living in New York which led to the conclusion that empirical data has much to say and discusses the theoretical-methodological contributions in a recent master's thesis in education. (BT)

  6. Joint Confirmatory Factor Analyses of the DAS and WISC-R.

    ERIC Educational Resources Information Center

    Stone, Brian J.

    1992-01-01

    Investigated joint factor structure of Differential Abilities Scale and Wechsler Intelligence Scale for Children-Revised for 115 children. Compared theoretically supportable models (Spearman's General factor; Wechsler's Verbal, Performance, and Freedom from Distractibility factors; Elliott's verbal, nonverbal, spatial, and diagnostic perspective)…

  7. [Dementia in patients of Hospital das Clínicas da UNICAMP].

    PubMed

    Silva, David W; Damasceno, Benito P

    2002-12-01

    To report the relative frequencies of the causes of dementia in patients seen at UNICAMP Hospital. From 1989 to 1998, 261 dementia patients were admitted (89.7% studied retrospectively, and 10.3%, prospectively); mean age 63.5 years (+/-13.2), and education 3.6 years +/- 3.9; 25% illiterate). Diagnosis of dementia and its subtypes was based on DSM-IV criteria, CAMDEX, NINCDS-ADRDA, NINDS AIREN/ADDTC, Lund-Manchester, besides tap-test, including laboratory and neuroimaging examinations. Sixty five patients (24.9%) had vascular dementia, 62 ( 23.7%) Alzheimer's, 29 (11.1%) depressive pseudodementia, 28 (10.9%) normal pressure hydrocephalus, 14(5.4%) mixed, 12 (4.6%) post-traumatic, 9 (3.4%) frontotemporal and 38 (14.5%) had diverse or unknown causes. Dementia was minimal or mild in 123 (47.1%), moderate in 95 (36.4%), and severe in 43 (16.5%). Frequency of vascular dementia was 24.9%, Alzheimer's 23.7%, and normal pressure hydrocephalus 10.7%, in disagreement with that found in the neurological literature (20-30%, 50%, and 1-4%, respectively), probably because we are dealing with cases admitted to a tertiary university hospital. Epidemiological studies are needed to disclose the true proportion of these dementia syndromes in the population.

  8. Deutsch als Fremdsprachenphilologie: Das Heidelberger Modell (German as a Foreign Language Philology: The Heidelberg Model)

    ERIC Educational Resources Information Center

    Dietrich, Rainer; Heuer, Fritz

    1975-01-01

    German as a Foreign Language Philology is a new subject developed at the New Philology Faculty of the University of Heidelberg. Students whose native language is not German can earn a Master of Arts in this field. The study plan, educational goals, and the content and organization of the curriculum are described. (Text is in German.) (TL)

  9. Das Sprachlabor und der Audiovisuelle Unterricht (The Language Laboratory and Audiovisual Instruction).

    ERIC Educational Resources Information Center

    Freudenstein, Reinhold, Ed.

    Four articles, written in German, discuss such aspects of the language laboratory as: teaching pronunciation in the laboratory (Heinrich Schrand), the dummy-element in transformational grammar (Helmut Heuer), testing in the language laboratory (Kenneth S. Leigh), and language laboratory work in Finland (Roland Freihoff). Nine book reviews on…

  10. Das Werden des Kosmos. Von der Erfahrung der zeitlichen Dimension astronomischer Objekte im 18. Jahrhundert.

    NASA Astrophysics Data System (ADS)

    Krafft, F.

    This paper deals with two of the initial stages through which the dimension of time, in the sense of an irreversible development, found its way into astronomical-cosmological thinking. The one resulted from the first consequential application of Newtonian principles and laws to cosmic entities outside of our solar system found in the "General Natural History or Theory of the Heavens" by Immanuel Kant. The other initial stage is found in the classification of 'nebulae' by William Herschel who introduced the historical time factor as a principle of order in addition to the outward shape, which had become common for all the different elements in natural history during the second half of the 18th century.

  11. Renewing information infrastructure at Hospital das Clínicas.

    PubMed Central

    Moura, L.; do Amaral, M. B.; Lira, A.; Tachinardi, U.; Teixeira, A. C.; Yamamoto, J.

    1998-01-01

    In this paper we describe the process of renewing the Informatics infrastructure of Sao Paulo University Medical School Hospital, a very complex environment. Our proposal consists of a change in the paradigm of Informatics and the use of Information Technology in the hospital. That change aims at making information available to the hospital, its managers, health care workers and patients. The paradigm change is reflected in every aspect of the new infrastructure: human resources, methods, and organizational structure, as we intend to demonstrate in this paper. This process is expected to be concluded by the end of this year, yielding benefits regarding costs, efficiency, and better patient care. PMID:9929210

  12. Bring Back "Das Kapital" Punishment! Credit Crunch and the Fall of the "Knowledge Economy"

    ERIC Educational Resources Information Center

    Stronach, Ian; Clarke, John

    2010-01-01

    This article contrasts the collapse of the twin political certainties of the 20th century--"scientific socialism" (1989) and "scientific capitalism" (2008). Such a collapse restores Uncertainty to her throne, and brings back the need to radically rethink political possibilities for the future. (Contains 1 note.)

  13. 50 CFR 648.53 - Target total allowable catch, DAS allocations, and individual fishing quotas.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... a Confirmation of Permit History as described in § 648.4(a)(1)(i)(J) for the entire fishing year... confirmation of permit history shall not be issued more than 2 percent of the TAC allocated to the IFQ scallop... permit history, or issued or renewed a limited access scallop permit or confirmation of permit...

  14. Bring Back "Das Kapital" Punishment! Credit Crunch and the Fall of the "Knowledge Economy"

    ERIC Educational Resources Information Center

    Stronach, Ian; Clarke, John

    2010-01-01

    This article contrasts the collapse of the twin political certainties of the 20th century--"scientific socialism" (1989) and "scientific capitalism" (2008). Such a collapse restores Uncertainty to her throne, and brings back the need to radically rethink political possibilities for the future. (Contains 1 note.)

  15. O Universo das Sociedades Numa Perspectiva Relativa: Exercícios de Etnoastronomia

    NASA Astrophysics Data System (ADS)

    Fares, Érika Akel; Pessoa Martins, Karla; Maciel Araujo, Lidiane; Sauma Filho, Michel

    2004-12-01

    This work developed at the Planetarium of Pará employing workshops designed for visitor schools (public, private, specials groups), promotes the popularization of the Ethnoastronomy with the aim of diffusing values based on a cultural diversity tolerance and the need of harmonic interplay between people and environment. Using stories and debates, the relationship between humans and the Cosmos is traced from antiquity until today, with the help of slides as a didactic resource. Thus, many conceptions about the origin of the Universe are shown; as well as some constellations created along the History, ending with the present scientific manner of know and explain the World. We then demonstrate the links between space, time and culture with the Cosmos vision. The need to think the World within a plural context to create respect for other different persons is emphasized. Este trabalho, desenvolvido no Planetário do Pará através de oficinas com escolas visitantes (públicas, privadas e grupos especiais), promove a popularização da Etnoastronomia, com o objetivo de difundir valores pautados na tolerância à diversidade cultural e na necessidade da convivência harmônica entre o ser humano e o meio ambiente. Através da contação de histórias e promoção de debate, é tratada a relação dos humanos com o céu desde a antiguidade até os dias atuais, tendo como apoio didático o uso de slides. Assim, são mostradas diversas concepções de origem do Universo; algumas constelações criadas no decorrer da História; e a atual forma científica de conhecer e explicar o mundo. Demonstrando-se, então, a interligação entre espaço, tempo e cultura com a visão do Cosmo. Enfatiza-se a necessidade de se pensar o mundo numa perspectiva relativa ou plural, de forma a propiciar o respeito ao ser diferente.

  16. Diskrepanzen und Kongruenzen: Das Dilemma des afrikanischen Kindes zwischen Familie und Schule

    NASA Astrophysics Data System (ADS)

    Bauer, Annemarie

    1986-03-01

    This article expounds the theory that the failure of school is due to the incompatibility of the educational goals of school and traditional upbringing in Africa. The thesis is put forward by adherents of the psychoanalytical model of child development and seeks to emphasize the discrepancies between the childhood where children are not frustrated and where their needs are cared for and the school education which represses the drives and its socialization of children. Finding a number of anthropological studies are discussed and reinterpretations of the ethno-psychoanalytical materials attempted. Neither the evaluation of childhood in Africa nor the theory that with school come wholly new expectations of behaviour (e.g., a performance requirement) can no longer be maintained. In conclusion, other explanations for the difficulties encountered by school in Africa are offered.

  17. Das Schwimmen der Talitridae (Crustacea, Amphipoda): Funktionsmorphologie, Phänomenologie und Energetik

    NASA Astrophysics Data System (ADS)

    Vogel, Friedhelm

    1985-09-01

    The Talitridae, well-known for their jumping behaviour, swim with help of the tail-flip. This movement of the abdomen is also known from other amphipods like the Gammaridae which are normally not able to move by jerks outside the water. The suspected homology between the tail-flip when swimming and the jerky movement of the abdomen when jumping gave rise to this investigation, mainly based on high frequency film recordings, on the swimming of Hyale nilssonii, Orchestia cavimana, and Talitrus saltator (family Talitridae) as well as three related species of the families Gammaridae and Corophiidae. Comparative morphometrical and SEM-studies on the habitus of the species and the build of the involved limbs reveal the rather uniform construction of the Gammaridea; functional adaptation to the environment and to the way of living become apparent in minor alterations. The joints of the pleopods and uropods show a clear structural adaptation to the mechanical strain during swimming. The pleopods are moved metachronally in all examined species; angular velocity and rate of beating indicate the efficiency of the swimming movement. In the Talitridae, the metachronal beat of the pleopods is nearly always coupled with the tail-flip while in the Gammaridae and Corophiidae the tail-flip, in addition to the beat of the pleopods, is mostly used for a start from the subsoil or for a change in swimming direction. H. nilssonii, Gammarus locusta, and Corophium volutator, all inhabitants of the tidal zone in the North Sea shallows, turned out to be the “best” swimmers while the (semi-) terrestrially living species, O. cavimana and T. saltator, proved to be rather “poor” swimmers. This clearly indicates the ecological significance of swimming for the different species. Furthermore, the tailflip is found to be of rather subordinate importance. It contributes to a higher velocity if used moderately but is rather obstructive if a large angle is covered while extending and flexing the abdomen. The efficiency of swimming is inversely proportional to the efficiency of jumping in the three talitridean species. Thus, better adaptation to terrestrial life is accompanied by loss of swimming efficiency. Examined under the aspect of locomotional homology, it is concluded that the tail-flip used while swimming is homologous to the jerky movement of the abdomen used for jumping. The comparison of the swimming performance of the examined species with other crustaceans and some fishes illustrates the over-all good results of the Gammaridea.

  18. Das Bild der Aufklarungspadagogik im Spiegel Deutschsprachiger Padagogischer Lexika Des 19. und 20. Jahrhunderts.

    ERIC Educational Resources Information Center

    Luth, Christoph

    1990-01-01

    Examines the educational lexicons of the nineteenth and twentieth centuries in order to investigate the influence of educational theories of the Enlightenment on Germany. Expounds on the educational theories of the Enlightenment. (RW)

  19. Das Smart Meter Gateway - Der kritische Erfolgsfaktor für die Digitalisierung der Energiewende

    NASA Astrophysics Data System (ADS)

    Abs, Paul-Vincent

    Der kritische Erfolgsfaktor der Digitalisierung in der Energiewirtschaft liegt im bevorstehenden hohen Investitionsvolumen und der Beherrschung der neuen Technik. Ein Weg zur Kostenminimierung liegt im Zusammenschluss der einzelnen Akteure, um gemeinsame Skalenvorteile zu heben. Auch bieten neue Geschäftsmodelle die Möglichkeit, zusätzliche Erlöse zu generieren.

  20. Ein Mensch ist ein Tier, das Schuhe tragt: Communication not Manipulation

    ERIC Educational Resources Information Center

    Sanders, Ruth H.

    1978-01-01

    A technique is described for eliciting true communication in the elementary German classroom which is also applicable to more advanced study. Students define simple words in German and are encouraged to help one another build a cumulative definition. The instructor reinforces the concept of language as a social activity. (SW)

  1. Consideracoes Extemporaneas acerca das Metodologias Qualitativas (Extemporaneous Considerations about Qualitative Methodology).

    ERIC Educational Resources Information Center

    Pucci, Bruno

    2000-01-01

    Considers the differences between quantitative and qualitative research. Cites some essays by Adorno when he was living in New York which led to the conclusion that empirical data has much to say and discusses the theoretical-methodological contributions in a recent master's thesis in education. (BT)

  2. ModSAF-Based Development of DAS for Light Armoured Vehicles

    DTIC Science & Technology

    2002-08-01

    Target Modeling and Validation Conference [13th] Held in Houghton, MI on 5-8 August 2002 To order the complete compilation report, use: ADA459530 The...produce accurate effects of attenuation over distance, scattering by smoke and dust and insolation. Spectral effects in the atmosphere, such Ground Target ... targeting information supplied by the UAV. Active armour is used to counter kinetic energy threats more effectively. The Radar system mentioned aboveis an

  3. A Integracao de Ensino das Ciencias da Saude (An Integrated Medical Education Program [in Brazil]).

    ERIC Educational Resources Information Center

    Pourchet-Campos, M. A.; Guimaraes Junior, Paulino

    At the Sixth Annual Reunion of the Brazilian Association of Medical Schools (VI Reuniao Anual da Associacao Brasileira de Escolas Medicas) leaders in the Brazilian medical profession proposed an integrated educational program for training students in the fields of medicine and public health. Under Brazil's present system of education, all…

  4. Kepler, Galilei, the telescope and the consequences. (German Title: Kepler, Galilei, das Fernrohr und die Folgen)

    NASA Astrophysics Data System (ADS)

    Hamel, Jürgen

    In the beginning Copernicus' system of the world did not have empirical confirmation. In this situation, Kepler's research, as well as the astronomical observations with the telescope, invented in 1608, played a decisive role. Under the assumption of the central position of the Sun, Kepler discovered the elliptical orbital motion of the planets as a base of the computation of noticeably improved ephemerides. The first telescopic observations - Jupiter's moons, phases of Venus, sunspots, surface features of the moon -, gave important arguments for Copernicus' system. Galilei was one of the first who used the telescope for astronomical research.

  5. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... trip via VMS. (9) Vessels issued a Tier 1, Tier 2, or Tier 3 limited access Atlantic mackerel permit... mackerel VMS notification requirements. (1) A vessel issued a limited access Atlantic mackerel permit intending to declare into the mackerel fishery must notify NMFS by declaring a mackerel trip prior...

  6. The Shadow of a Gnomon Along a Year: Routine Observations and Teaching of Apparent Motion of the Sun and the Four Seasons. (Spanish Title: La Sombra de un Gnomon lo Largo de un Año: Observaciones de Rutina y la Enseñanza del Movimiento Aparente del Sol y Las Cuatro Estaciones.) A Sombra de um Gnômon ao Longo de um Ano: Observações Rotineiras e o Ensino do Movimento Aparente do Sol E das Quatro Estações

    NASA Astrophysics Data System (ADS)

    Trogello, Anderson Giovani; Danhoni Neves, Marcos Cesar; de Carvalho Rutz da Silva, Sani

    2013-12-01

    , al solsticio de junio, al equinoccio de septiembre y al solsticio de diciembre. Además, se dictaron clases teóricas en la sala de aula. Estos métodos buscaron construir conceptos en torno al movimiento aparente del Sol y la sucesión de las estaciones. Teniendo en cuenta los resultados de las actividades se aplicó una evaluación cuyos datos demuestran la existencia de un aprendizaje deseado por los estudiantes en cuanto a: el reconocimiento de los puntos cardinales, la descripción del movimiento solar aparente y la aparición de las estaciones y su alternancia a partir de observaciones astronómicas visuales sin instrumentos. Muitas concepções alternativas são reconhecidas entre os diversos grupos de estudantes, em especial nos da educação básica. Dentre elas, o movimento aparente do Sol, por mais quotidiano que seja, proporciona variadas interpretações. Deste modo, observar e registrar o movimento dos astros na abóboda celeste é uma tarefa necessária ao ensino de Astronomia. O trabalho que ora se apresenta propõe a apresentação dos resultados da observação do movimento aparente do Sol por intermédio da marcação da sombra de um gnômon vertical por alunos de uma turma do sexto ano do ensino fundamental de uma escola do campo do Paraná. O projeto em si ocorreu em quatro etapas, em datas próximas do equinócio de março, do solstício de junho, do equinócio de setembro e do solstício de dezembro. Além disso, foram desenvolvidas aulas teóricas em sala de aula. Tais métodos buscaram construir conceitos em torno da movimentação aparente do Sol e da alternância das estações do ano. Diante dos resultados provenientes das atividades desenvolvidas foi aplicada uma avaliação e os dados demonstraram um aprendizado desejado dos alunos quanto: ao reconhecimento dos pontos cardeais; à descrição do movimento solar aparente e a ocorrência das estações do ano e sua alternância a partir de observações astronômicas a olho nu.

  7. Das Problem der Ubersetzbarkeit von Phraseologismen am Beispiel von Isabel Allendes Roman "Das Geisterhaus" (The Problem of the Translatability of Idioms using the Example of Isabel Allende's novel "The House of the Spirits").

    ERIC Educational Resources Information Center

    Cox, Luz

    1996-01-01

    Using the translation of Isabel Allende's novel "The House of the Spirits," this essay demonstrates that the mastery of a foreign language does not guarantee a translation true to the original. The Spanish of the Latin American countries exhibits numerous differences and does not always share a uniform vocabulary. Concrete measures are…

  8. Das Problem der Ubersetzbarkeit von Phraseologismen am Beispiel von Isabel Allendes Roman "Das Geisterhaus" (The Problem of the Translatability of Idioms using the Example of Isabel Allende's novel "The House of the Spirits").

    ERIC Educational Resources Information Center

    Cox, Luz

    1996-01-01

    Using the translation of Isabel Allende's novel "The House of the Spirits," this essay demonstrates that the mastery of a foreign language does not guarantee a translation true to the original. The Spanish of the Latin American countries exhibits numerous differences and does not always share a uniform vocabulary. Concrete measures are…

  9. Neues "Francais fondamental?" Das Europa-Projekt "Un niveau seuil." (A New "Francais fondamental?" The European Project "A Threshold Level").

    ERIC Educational Resources Information Center

    Raasch, Albert

    1978-01-01

    The project "Threshold Level," initiated by the Council of Europe in 1976, is compared with "Francais fondamental," comparing their aims and their differences. Offered as an interim statement, the article leaves open the question of whether Francais fondamental should be replaced by the the Threshold Level. (IFS/WGA)

  10. Die physikalischen Umweltwissenschaften und das Militär Zur Erforschung Grönlands im Kalten Krieg

    NASA Astrophysics Data System (ADS)

    Heymann, Matthias

    Die modernen Umweltwissenschaften stehen heute im Mittelpunkt von Forschungsförderung und öffentlicher Aufmerksamkeit. Im Zuge des seit den 1970er Jahren erwachten Interesses am globalen Wandel der Umwelt und den damit verknüpften Problemen, ist ihre Bedeutung rasch gestiegen. Viele Wurzeln der modernen Umweltwissenschaften liegen jedoch im Kalten Krieg.

  11. Dermatomyositis: analysis of 109 patients surveyed at the Hospital das Clínicas (HCFMUSP), São Paulo, Brazil*

    PubMed Central

    Ortigosa, Luciena Cegatto Martins; dos Reis, Vitor Manuel Silva

    2014-01-01

    BACKGROUND Dermatomyositis affects striated muscles, skin and other organs. OBJECTIVE To characterize the disease from January 1992 to December 2002, assessing its classification, cutaneous and systemic manifestations, and also laboratory results, therapeutic and prognostic findings compared to those in the literature. METHODS Data were obtained from medical records of 109 patients who were classified into five groups: 23 juvenile dermatomyositis; 59 primary idiopathic dermatomyositis; 6 amyopathic dermatomyositis; 7 dermatomyositis associated with neoplasms and 14 dermatomyositis associated with other connective tissue diseases. RESULTS Sixty patients were classified as "definite" diagnosis; 33 as "possible"; four as "probable" and 12 and as amyopathic. The average age at diagnosis was 36 years. Cutaneous manifestations occurred in all patients; the most frequent symptom was loss of proximal muscle strength; the most common pulmonary disorder was interstitial lung disease, and gastritis was the most prevalent digestive manifestation. Tumors were documented in 6.42% of cases. Lactate dehydrogenase was the muscle enzyme most frequently elevated in the majority of cases. Skin biopsies were performed in 68 patients; muscle biopsies in 53; and electroneuromyographies in 58 patients. The most commonly used treatment was corticotherapy and the mortality rate was 14.7%. CONCLUSION in this sample, the disease appeared in younger individuals, was more frequent in women and the association with cancer was small. PMID:25184910

  12. Dermatomyositis: analysis of 109 patients surveyed at the Hospital das Clínicas (HCFMUSP), São Paulo, Brazil.

    PubMed

    Ortigosa, Luciena Cegatto Martins; Reis, Vitor Manuel Silva dos

    2014-01-01

    Dermatomyositis affects striated muscles, skin and other organs. To characterize the disease from January 1992 to December 2002, assessing its classification, cutaneous and systemic manifestations, and also laboratory results, therapeutic and prognostic findings compared to those in the literature. Data were obtained from medical records of 109 patients who were classified into five groups: 23 juvenile dermatomyositis; 59 primary idiopathic dermatomyositis; 6 amyopathic dermatomyositis; 7 dermatomyositis associated with neoplasms and 14 dermatomyositis associated with other connective tissue diseases. Sixty patients were classified as "definite" diagnosis; 33 as "possible"; four as "probable" and 12 and as amyopathic. The average age at diagnosis was 36 years. Cutaneous manifestations occurred in all patients; the most frequent symptom was loss of proximal muscle strength; the most common pulmonary disorder was interstitial lung disease, and gastritis was the most prevalent digestive manifestation. Tumors were documented in 6.42% of cases. Lactate dehydrogenase was the muscle enzyme most frequently elevated in the majority of cases. Skin biopsies were performed in 68 patients; muscle biopsies in 53; and electroneuromyographies in 58 patients. The most commonly used treatment was corticotherapy and the mortality rate was 14.7%. in this sample, the disease appeared in younger individuals, was more frequent in women and the association with cancer was small.

  13. Neues "Francais fondamental?" Das Europa-Projekt "Un niveau seuil." (A New "Francais fondamental?" The European Project "A Threshold Level").

    ERIC Educational Resources Information Center

    Raasch, Albert

    1978-01-01

    The project "Threshold Level," initiated by the Council of Europe in 1976, is compared with "Francais fondamental," comparing their aims and their differences. Offered as an interim statement, the article leaves open the question of whether Francais fondamental should be replaced by the the Threshold Level. (IFS/WGA)

  14. ExactDAS: an exact test procedure for the detection of differential alternative splicing in microarray experiments.

    PubMed

    Mary-Huard, Tristan; Jaffrezic, Florence; Robin, Stéphane

    2012-11-06

    The aim of this paper is to propose a test procedure for the detection of differential alternative splicing across conditions for tiling array or exon chip data. While developed in a mixed model framework, the test procedure is exact (avoiding computational burden) and applicable to a large variety of contrasts, including several previously published ones. A simulation study is presented to evaluate the robustness and performance of the method. It is found to have a good detection power of genes under differential alternative splicing, even for five biological replicates and four probes per exon. The methodology also enables the comparison of various experimental designs through exact power curves. This is illustrated with the comparison of paired and unpaired experiments. The test procedure was applied to two publicly available cancer data sets based on exon arrays, and showed promising results.

  15. 50 CFR 648.53 - Acceptable biological catch (ABC), annual catch limits (ACL), annual catch targets (ACT), DAS...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... divided as sub-ACLs between limited access vessels, limited access vessels that are fishing under a... limited access fishery sub-ACLs for fishing years 2011 through 2013 are: (A) 2011: 24,954 mt. (B) 2012: 26... catch, observer set-aside, and research set-aside, as specified in this paragraph (a). The LAGC ACLs...

  16. 50 CFR 648.53 - Acceptable biological catch (ABC), annual catch limits (ACL), annual catch targets (ACT), DAS...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... divided as sub-ACLs between limited access vessels, limited access vessels that are fishing under a LAGC... adjustment. (i) The limited access fishery sub-ACLs for fishing years 2014 and 2015 are: (A) 2014: 18,885 mt...). (i) The ACLs for fishing years 2014 and 2015 for LAGC IFQ vessels without a limited access...

  17. 50 CFR 648.53 - Acceptable biological catch (ABC), annual catch limits (ACL), annual catch targets (ACT), DAS...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... divided as sub-ACLs between limited access vessels, limited access vessels that are fishing under a LAGC... adjustment. (i) The limited access fishery sub-ACLs for fishing years 2013 and 2014 are: (A) 2013: 19,093 mt... paragraph (a). (i) The ACLs for fishing years 2013 and 2014 for LAGC IFQ vessels without a limited...

  18. The First Time/Das Erstes Mal: Approaches to Virginity Loss in U.S. and German Teen Magazines.

    ERIC Educational Resources Information Center

    Carpenter, Laura M.

    2001-01-01

    Examined 76 stories about virginity loss, using ethnographic content analysis, from German and U.S. teen magazines. A substantial proportion of all sexuality-related material in the magazines concerned virginity. Both publications depicted virginity loss as a unique, salient sexual turning point and made similar recommendations for virginity loss.…

  19. Das Konstanzer Trainingsmodell (KTM) - Grundlagen und neue Entwicklungen (The Konstanz Training Model (KTM) -- Fundamental Principles and Recent Developments).

    ERIC Educational Resources Information Center

    Dann, Hanns-Dietrich; Humpert, Winfried

    2002-01-01

    Summarizes the Konstanz Training Model (KTM), a German primary and secondary preventive program that increases teacher self-competence and social competence in dealing with aggressive and disruptive student behaviors. Emphasizes KTM's focus on systemic aspects, cognitive level, and behavioral level approaches. Describes KTM Compact, a short term…

  20. Ökophysik: Plaudereien über das Leben auf dem Land, im Wasser und in der Luft

    NASA Astrophysics Data System (ADS)

    Nachtigall, W.

    Prof. em. Dr. rer. nat. Werner Nachtigall, geb. 1934, war als Zoophysiologe und Biophysiker Leiter des Zoologischen Instituts der Universität des Saarlandes in Saarbrücken. In Forschung und Ausbildung hat er sich insbesondere mit Aspekten der Technischen Biologie und Bionik befasst und mit seinen Forschergruppen viele Basisdaten insbesondere zur Ökologie, Physiologie und Physik des Fliegens und Schwimmens aber auch zur Stabilität beispielsweise der Gräser erarbeitet. Lebewesen überraschen immer wieder durch ihre "Biodiversität", ihre hochspezifischen Ausgestaltungen und Anpassungen.

  1. Hepatologie Neuere Forschungsergebnisse in ihrer Bedeutung für das Verständnis von Leberkrankheiten

    NASA Astrophysics Data System (ADS)

    Gerok, W.; Blum, H. E.; Offensperger, W.; Offensperger, S.; Andus, T.; Groß, V.; Heinrich, P. C.

    1991-06-01

    By two exemplary clinical situations — acute viral hepatitis, acute-phase reaction of the liver — the significance of basic research for the understanding of clinical phenomena and for the development of new diagnostic and therapeutic procedures is demonstrated. The very different phenomena following infection with the hepatitis-B-virus can be explained by the variation in the interactions of virus and liver cell, by the immune reaction of the host, and by mutants of the virus. The reaction of the liver to an extrahepatic infection is mediated by interleukin-6, and characterized by an alteration in protein metabolism. The synthesis of acute-phase proteins is increased. The proteins confine the local injury and establish the homeostasis of the organism.

  2. Das Pinealorgan der Wirbeltiere: ein Modell für Untersuchungen von Rezeptor-und Effektormechanismen in neuronalen Systemen

    NASA Astrophysics Data System (ADS)

    Korf, Horst-W.; Wicht, Helmut

    1991-10-01

    Cell and molecular biological investigations have greatly contributed to our understanding of receptor and effector mechanisms in sensory, neuronal, and endocrine cells. A fascinating aspect of this line of research is how such mechanisms have evolved and how they interact with each other. As shown in this contribution, the vertebrate pineal organ is an interesting model to study these problems, because it undergoes a conspicuous transformation during phylogeny, comprises two well-chraracterized receptor mechanisms (photoreception and adrenoreception), and acts upon its targets via neuronal and neuroendocrine signals.

  3. Werbung im Englischunterricht: Das Beispiel Einhorn - Onehorn - Unicorn (Advertising Material in English Teaching: The Example "Einhorn-Onehorn-Unicorn")

    ERIC Educational Resources Information Center

    Ruettgens, Hannelore

    1976-01-01

    Presents an advertisement from "Der Spiegel," composed in English that is saturated with Germanisms. Teaching procedures based on this are suggested: finding and classifying errors, composing alternative versions, translating into German, retranslating into English. Suggestions are given for further work based on the students' own…

  4. Eventorientierte Veranstaltungen und Lebensqualität innenstädtischer Wohnbevölkerung. Das Beispiel Bamberg

    NASA Astrophysics Data System (ADS)

    Redepenning, Marc; Rhein, Niklas; Sauerwald, David

    2016-09-01

    Events do have, in addition to economic effects, impact on the quality of life of the affected population. Using a case study from the city of Bamberg this article addresses the subjective contentment with larger events. The results show variation in the range of contentment depending on age and time of residency in the city. Furthermore, it becomes obvious that the particular expectation on "life in the inner city" shapes the contentment. Cities should pay attention to this social heterogeneity when deploying strategies of revitalisation through festivals and events. They should take it seriously by using tools of collaborative planning to preserve the multi-functionality of inner cities.

  5. Cloning and characterization of the DAS gene encoding the major methanol assimilatory enzyme from the methylotrophic yeast Hansenula polymorpha.

    PubMed

    Janowicz, Z A; Eckart, M R; Drewke, C; Roggenkamp, R O; Hollenberg, C P; Maat, J; Ledeboer, A M; Visser, C; Verrips, C T

    1985-05-10

    A gene library from the methanol utilizing yeast Hansenula polymorpha, constructed in a lambda Charon4A vector, was used to clone the gene encoding a key methanol assimilating enzyme, dihydroxyacetone synthase (DHAS) by differential plaque hybridization. The nucleotide sequence of the 2106 bp structural gene and the 5' and 3' non-coding regions was determined. The deduced amino acid sequence of the protein is in agreement with the apparent molecular weight and amino acid composition of the purified protein. The codon bias is not so pronounced as in some Saccharomyces cerevisiae genes.

  6. DAsHER CD: Developing a Data-Oriented Human-Centric Enterprise Architecture for EarthCube

    NASA Astrophysics Data System (ADS)

    Yang, C. P.; Yu, M.; Sun, M.; Qin, H.; Robinson, E.

    2015-12-01

    One of the biggest challenges that face Earth scientists is the resource discovery, access, and sharing in a desired fashion. EarthCube is targeted to enable geoscientists to address the challenges by fostering community-governed efforts that develop a common cyberinfrastructure for the purpose of collecting, accessing, analyzing, sharing and visualizing all forms of data and related resources, through the use of advanced technological and computational capabilities. Here we design an Enterprise Architecture (EA) for EarthCube to facilitate the knowledge management, communication and human collaboration in pursuit of the unprecedented data sharing across the geosciences. The design results will provide EarthCube a reference framework for developing geoscience cyberinfrastructure collaborated by different stakeholders, and identifying topics which should invoke high interest in the community. The development of this EarthCube EA framework leverages popular frameworks, such as Zachman, Gartner, DoDAF, and FEAF. The science driver of this design is the needs from EarthCube community, including the analyzed user requirements from EarthCube End User Workshop reports and EarthCube working group roadmaps, and feedbacks or comments from scientists obtained by organizing workshops. The final product of this Enterprise Architecture is a four-volume reference document: 1) Volume one is this document and comprises an executive summary of the EarthCube architecture, serving as an overview in the initial phases of architecture development; 2) Volume two is the major body of the design product. It outlines all the architectural design components or viewpoints; 3) Volume three provides taxonomy of the EarthCube enterprise augmented with semantics relations; 4) Volume four describes an example of utilizing this architecture for a geoscience project.

  7. Unternehmerische Verantwortung in der Stadt- und Regionalentwicklung. Einführung in das Themenheft "Corporate Regional Responsibility"

    NASA Astrophysics Data System (ADS)

    Kiese, Matthias; Schiek, Meike

    2016-03-01

    Firms assume increasing importance within co-operative modes of regional and urban governance. Further to just filling gaps left by the retreat of the welfare state, firms recognise the impact of their regional and local business environment on their performance, especially when it comes to attracting and retaining highly-skilled personnel. As an introduction to this issue, this contribution introduces the basic concept of corporate social responsibility and its regional variation, corporate regional responsibility.

  8. Fehler begehen - Mathematik verstehen Über die Bedeutung von Fehlern für das Verstehen

    NASA Astrophysics Data System (ADS)

    Käser, Udo

    Auch wenn eine historisch oder systematisch umfassende Darstellung zur Fehlerthematik bislang nicht vorliegt, ist die Idee, einer Fehleranalyse unter der Leitfrage, welche Fehler von Schülerinnen und Schülern aufgrund welcher epistemologischen Überzeugungen begangen werden, zentralen Raum für die Betrachtung von Verstehensprozessen einzuräumen, nicht neu. So ist es geradezu ein Charakteristikum einer modernen konstruktivistischen Didaktik, die eigenen Fehler von Lernenden als ihre individuellen Lerngelegenheiten zu begreifen, die einen wichtigen Motor für den subjektiven Lernfortschritt bilden. Diese Sichtweise wurzelt aus psychologischer Perspektive in Analysen in der Tradition Piagets, der in Abkehr von einer quantitativen, psychometrischen Beschreibung kognitiver Prozesse, wie sie sich zum Beispiel in Intelligenztheorien nach Binet findet, qualitativ zu beschreiben versuchte, in welcher Weise Kinder und Jugendliche denken und urteilen. Doch auch schon in der klassischen Philosophie sind entsprechende Ansätze zu finden. Prominente Beispiele hierfür sind die Idolenlehre Bacons und die Ideenlehre Platons.

  9. Bedeutung kleinräumiger Daten für die Evaluation von Bildungsprojekten. Das Beispiel der Junior Uni Wuppertal

    NASA Astrophysics Data System (ADS)

    Makles, Anna

    2016-12-01

    The Junior University, a University for children and youth in the city of Wuppertal, offers science courses that target children and youth from all socioeconomic backgrounds. The first evaluation study done by the University of Wuppertal in 2013 aimed at examining whether the Junior University has achieved this goal. The main challenge of our analysis was to approximate missing individual information on socioeconomic status by using spatial data. Therefore, we georeferenced address information of the Junior University students and linked those results to different characteristics available for about 2800 city blocks in the city of Wuppertal. We found out that indeed the Junior University succeeds in attracting children and youth from all socioeconomic backgrounds. The results show that many of the students live in poor neighborhoods or in neighborhoods with a high share of immigrants.

  10. Axisymmetric rotational stagnation point flow impinging radially a permeable stretching/shrinking surface in a nanofluid using Tiwari and Das model.

    PubMed

    Roşca, Natalia C; Pop, Ioan

    2017-01-12

    In this paper, the problem of normal impingement rotational stagnation-point flow on a radially permeable stretching sheet in a viscous fluid, recently studied in a very interesting paper, is extended to a water-based nanofluid. A similarity transformation is used to reduce the system of governing nonlinear partial differential equations to a system of ordinary differential equations, which is then solved numerically using the function bvp4c from Matlab. It is found that dual (upper and lower branch) solutions exist for some values of the governing parameters. From the stability analysis, it is found that the upper branch solution is stable, while the lower branch solution is unstable. Sample velocity and temperature profiles along both solution branches are graphically presented.

  11. Grüne Infrastruktur in den Städten Nordrhein-Westfalens. Bedeutung als Standortfaktor und Einfluss auf das Standortmarketing

    NASA Astrophysics Data System (ADS)

    Schäffer, Ina

    2016-06-01

    Hardly any other city in North Rhine-Westphalia has such a green image as the city of Münster. It embodies the image of a livable city in Germany. Other North Rhine-Westphalian cities also work on their external perception and are approaching the task of getting a greener image for themselves in many ways. A central question is how it is done precisely and whether urban green infrastructure can be a locational factor to affect location-based marketing. This article deals with the strategies of various cities in North Rhine-Westphalia.

  12. An analysis of seasonal changes in STE using measurements from the TOPSE campaign and the Beryllium-7 distribution from a calculation driven by the GEOS-3 DAS.

    NASA Astrophysics Data System (ADS)

    Allen, D. J.; Dibb, J. E.; Ridley, B.; Pickering, K. E.

    2002-05-01

    Measurements of tropospheric ozone (O3) between 30\\deg and 70\\deg N show springtime maxima at remote locations. The contribution of seasonal changes in stratosphere-troposphere exchange (STE) to these maxima was investigated using measurements from the Tropospheric Ozone Production about the Spring Equinox Experiment (TOPSE) campaign and the Beryllium-7 (7Be) distribution from a calculation driven by fields from the Goddard Earth Observing System Data Assimilation System. Comparison with TOPSE measurements revealed that upper tropospheric model-calculated 7Be mixing ratios were reasonable (a change from previous calculations) but that lower tropospheric mixing ratios were too low most likely due to an overestimation of scavenging. Temporal fluctuations were well captured although their amplitudes were often underestimated. Analysis of O3 measurements indicated that mixing ratios increased by 5-10% per month for θ < 300 K (the underworld) and by 10-15% per month for θ > 300 K (the tropospheric middleworld). 7Be mixing ratios decreased with time for θ < 290 K and increased with time for θ > 300 K. Model-calculated middleworld increases of 7Be were a factor of 2 less than measured increases. 7Be with a stratospheric source (strat-7Be) increased by 4.6-8.8% along TOPSE flight paths within the tropospheric middleworld. Increases in strat-7Be were not seen along TOPSE flight paths in the underworld. Assuming changes in O3 with a stratospheric source are the same as changes in strat-7Be and that 50% of O3 is produced in the stratosphere, changes in STE explain 20-60% of O3 increases in the tropospheric middleworld and less than 30% of O3 increases in the underworld.

  13. Mājsaimniecību Ietekme uz Klimatu Latvijā: Oglekļa Pēdas Rādītājs

    NASA Astrophysics Data System (ADS)

    Brizga, J.; Kudreņickis, I.

    2009-01-01

    People more and more recognize climate change as one of the main environmental problems and the term `carbon footprint' (CF) has become popular and is now in widespread use. In this paper, the CF concept has been applied to analyse average per capita household Greenhouse Gas (GHG) emissions in Latvia. We explore household CF in housing (heating and electricity consumption), transport, food and goods and service sectors, which are the main household environmental pressure areas. This paper provides an understanding of both direct and indirect (embodied) GHG emissions. Results from the study suggest that the average Latvian exceeds its global fair share of GHG emissions - the average per capita GHG in 2006 was 4.35 t CO2e. The highest household emissions arise from housing (37%), mobility (26%) and food consumption (25%), goods and services together account only for 12% of total household GHG emissions. This study, however, does not cover capital investments in infrastructure (roads, public buildings etc.) which could increase total emission by almost a ton. The study emphasizes that attention must be paid to the lifestyles, infrastructure and institutions that result in considerable amounts of carbon being locked up in the household activities through which people meet their everyday needs. The findings also indicate that policies should be targeted at the segments in society responsible for the highest carbon footprints, ie. housing, food and mobility.

  14. Efeitos dos sais na planta e tolerância das culturas à salinidade (Salinity effects on plants and tolerance of crops to salinity)

    USDA-ARS?s Scientific Manuscript database

    The major challenge for world agriculture today is to maintain food and water supplies that can meet the demands of a growing world population. The shortage of fresh water, and its use mainly for human consumption, leaves the farmers with the choice of using reclycled city water, or underground sali...

  15. Mobilitätslösungen für den ländlichen Raum. Das Beispiel VSB Verkehrsverbund Schwarzwald-Baar in Baden-Württemberg

    NASA Astrophysics Data System (ADS)

    Mager, Thomas J.

    2017-09-01

    The current public transport situation in rural areas is characterized by strong changes in legal, economic, demographic and above all political influence factors. In Baden-Württemberg, student transportation funding has changed as part of the municipalization of compensation payments pursuant to § 45a of the Public Transportation Act. This will affect public transportation in rural areas, especially in the southern Baden region, which accounts for 80% of all rural public transportation. In order to maintain public transportation in rural areas, new models of long-term financing independent of student numbers should be developed and applied in combination with alternative and less traditional service offerings. This article discusses the example of the VSB transport association Schwarzwald-Baar, which offers mobility solutions in rural areas.

  16. Lemaître, the expanding universe, and the cosmological constant (German Title: Lemaître, das expandierende Universum und die kosmologische Konstante )

    NASA Astrophysics Data System (ADS)

    Roessler, Kurt

    The scientific and human relations of Albert Einstein and Georges Lemaître are discussed. In 1927 the later had interpreted the general theory of relativity for a model of an expanding cosmos using a positive value of the cosmological constant. In the three open questions between them: expansion of cosmos, primordial state of a quantum vacuum (``primeval atom''), importance of the cosmological constant for vacuum energy, Lemaître finally won over the heavily opposing Einstein. The philosophical and ontological tendency of Einstein's thinking was contrasted with the strict epistemological line of the catholic priest Lemaître. The dramatic changes between friendship and controversy finally led to a diminution of Lemaître's reputation as ``Darwin of Cosmology''. In that case, the late Einstein proved to be a hindrance rather than a promoter of evolution in cosmology.

  17. Axisymmetric rotational stagnation point flow impinging radially a permeable stretching/shrinking surface in a nanofluid using Tiwari and Das model

    NASA Astrophysics Data System (ADS)

    Roşca, Natalia C.; Pop, Ioan

    2017-01-01

    In this paper, the problem of normal impingement rotational stagnation-point flow on a radially permeable stretching sheet in a viscous fluid, recently studied in a very interesting paper, is extended to a water-based nanofluid. A similarity transformation is used to reduce the system of governing nonlinear partial differential equations to a system of ordinary differential equations, which is then solved numerically using the function bvp4c from Matlab. It is found that dual (upper and lower branch) solutions exist for some values of the governing parameters. From the stability analysis, it is found that the upper branch solution is stable, while the lower branch solution is unstable. Sample velocity and temperature profiles along both solution branches are graphically presented.

  18. [Hospital bacteremia at the "Instituto do Coração do Hospital das Clínicas da FMUSP": a four-year retrospective study].

    PubMed

    Camargo, L F; Strabelli, T M; Ribeiro, F G; Mendes, C M; Uip, D E; Bellotti, G M; Pileggi, F J

    1994-01-01

    We conducted a retrospective study to establish mortality rates and prevalence of nosocomial bacteremias at our institute. We found 1.21 nosocomial bacteremias per 100 hospital discharges with an overall Mortality rate of 29.5%. Primary bacteremias increased during the four-year-study-period from 31 to 41%. Staphylococcus, both coagulase-positive and coagulase-negative, was the bacteria most frequently isolated. An abrupt increase in the isolation of P.aeruginosa occurred in 1992. We concluded that a blood-culture surveillance program is required for determining an endemic rate.

  19. Die regionalökonomische Bedeutung der Wissenschaft für das Ruhrgebiet. Hochschulen und außeruniversitäre Forschungseinrichtungen als Motor der regionalen Entwicklung

    NASA Astrophysics Data System (ADS)

    Kriegesmann, Bernd; Böttcher, Matthias; Lippmann, Torben

    2016-09-01

    The Ruhr area has advanced to the largest university region in Germany - often unnoticed within and outside. At the same time scientific institutions have become a major economic factor. Because of the higher and extra-university research institutions about 2.5 billion euros are effective as a demand potential in the region. 1.7 billion euros of this amount are directly associated with investments and operating expenditures of the scientific institutions as well as consumptions of employees and students. Additional 770 million euros result in revenues of many branches such as trade, housing, gastronomy sector, handcraft industry etc. It should not be underestimated that higher and extra-university research institutions generate with their research activities particular funding from the European Union or the rest of Germany for benefit of the region. Each euro spent by the state government for basic funding creates 39 cents third-party funding. These regional-economic effects result in noticeable employment impacts within the region. Around 25,000 people are directly employed in higher and extra-university research institutes or student unions (Studierendenwerke), about 22,000 jobs in other economic sectors are ensured or created by the induced demand. Science has thus become an important economic factor and represents an essential counterbalance to employment decline in shrinking industries of the region. The specific inclusion of science in a regional development strategy and targeted relining with appropriate measures to strengthen the science creates therefore an effective starting point for the design of structural change.

  20. Längengrad. Die wahre Geschichte eines einsamen Genies, welches das größte wissenschaftliche Problem seiner Zeit löste.

    NASA Astrophysics Data System (ADS)

    Sobel, D.

    This book is a German translation, by M. Fienbork, from the American original "Longitude", published in 1995. It tells the story of John Harrison (1693 - 1776), the inventor of a chronometer for precise time determination onboard of ships.

  1. Conceptual design of the CZMIL data acquisition system (DAS): integrating a new bathymetric lidar with a commercial spectrometer and metric camera for coastal mapping applications

    NASA Astrophysics Data System (ADS)

    Fuchs, Eran; Tuell, Grady

    2010-04-01

    The CZMIL system is a new generation airborne bathymetric and topographic remote sensing platform composed of an active lidar, passive hyperspectral imager, high resolution frame camera, navigation system, and storage media running on a linux-based Gigabit Ethernet network. The lidar is a hybrid scanned-flash system employing a 10 KHz green laser and novel circular scanner, with a large aperture receiver (0.20m) having multiple channels. A PMT-based segmented detector is used on one channel to support simultaneous topographic and bathymetric data collection, and multiple fields-of- view are measured to support bathymetric measurements. The measured laser returns are digitized at 1 GHz to produce the waveforms required for ranging measurements, and unique data compression and storage techniques are used to address the large data volume. Simulated results demonstrate CZMIL's capability to discriminate bottom and surface returns in very shallow water conditions without compromising performance in deep water. Simulated waveforms are compared with measured data from the SHOALS system and show promising expected results. The system's prototype is expected to be completed by end of 2010, and ready for initial calibration tests in the spring of 2010.

  2. Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) – short version

    PubMed Central

    Baron, Ralf; Binder, Andreas; Biniek, Rolf; Braune, Stephan; Buerkle, Hartmut; Dall, Peter; Demirakca, Sueha; Eckardt, Rahel; Eggers, Verena; Eichler, Ingolf; Fietze, Ingo; Freys, Stephan; Fründ, Andreas; Garten, Lars; Gohrbandt, Bernhard; Harth, Irene; Hartl, Wolfgang; Heppner, Hans-Jürgen; Horter, Johannes; Huth, Ralf; Janssens, Uwe; Jungk, Christine; Kaeuper, Kristin Maria; Kessler, Paul; Kleinschmidt, Stefan; Kochanek, Matthias; Kumpf, Matthias; Meiser, Andreas; Mueller, Anika; Orth, Maritta; Putensen, Christian; Roth, Bernd; Schaefer, Michael; Schaefers, Rainhild; Schellongowski, Peter; Schindler, Monika; Schmitt, Reinhard; Scholz, Jens; Schroeder, Stefan; Schwarzmann, Gerhard; Spies, Claudia; Stingele, Robert; Tonner, Peter; Trieschmann, Uwe; Tryba, Michael; Wappler, Frank; Waydhas, Christian; Weiss, Bjoern; Weisshaar, Guido

    2015-01-01

    In 2010, under the guidance of the DGAI (German Society of Anaesthesiology and Intensive Care Medicine) and DIVI (German Interdisciplinary Association for Intensive Care and Emergency Medicine), twelve German medical societies published the “Evidence- and Consensus-based Guidelines on the Management of Analgesia, Sedation and Delirium in Intensive Care”. Since then, several new studies and publications have considerably increased the body of evidence, including the new recommendations from the American College of Critical Care Medicine (ACCM) in conjunction with Society of Critical Care Medicine (SCCM) and American Society of Health-System Pharmacists (ASHP) from 2013. For this update, a major restructuring and extension of the guidelines were needed in order to cover new aspects of treatment, such as sleep and anxiety management. The literature was systematically searched and evaluated using the criteria of the Oxford Center of Evidence Based Medicine. The body of evidence used to formulate these recommendations was reviewed and approved by representatives of 17 national societies. Three grades of recommendation were used as follows: Grade “A” (strong recommendation), Grade “B” (recommendation) and Grade “0” (open recommendation). The result is a comprehensive, interdisciplinary, evidence and consensus-based set of level 3 guidelines. This publication was designed for all ICU professionals, and takes into account all critically ill patient populations. It represents a guide to symptom-oriented prevention, diagnosis, and treatment of delirium, anxiety, stress, and protocol-based analgesia, sedation, and sleep-management in intensive care medicine. PMID:26609286

  3. [Hospitalizations at Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, USP, 1996-2003].

    PubMed

    Chaves, Lucieli Dias Pedreschi; Laus, Ana Maria; Anselmi, Maria Luiza

    2009-03-01

    Hospitalizations represent an important share of healthcare, due to both the complexity of actions and the financial volume applied. This descriptive-exploratory investigation had the purpose to identify and describing the physical and financial production of hospitalizations performed in a school hospital in the state of São Paulo, from 1996 to 2003, focusing the specialties of surgical clinic, medical clinic, pediatrics and obstetrics. Data collection was performed by searching the official databanks of the studied institution. In that period, a global 8.5% reduction in the frequency of admittances and a 78.4% increase in the financial resources were observed. Surgical clinic, with more expensive procedures, increased its admittances; the production in obstetrics showed the lowest variation. The increasing incorporation of technology, the demands from regional users and the migration of users from the supplementary system to the SUS may justify the variation of production in the different specialties.

  4. Coronary artery disease treatment in dialysis patients at the Hospital das Clínicas da Faculdade de Medicina de Botucatu--UNESP.

    PubMed

    Vieira, Paula Ferreiro; Garcia, Paula Dalsoglio; Bregagnollo, Edson Antonio; Carvalho, Fábio Cardoso; Kochi, Ana Cláudia; Martins, Antonio Sérgio; Caramori, Jaqueline Costa Teixeira; Franco, Roberto Jorge da Silva; Barretti, Pasqual; Martin, Luis Cuadrado

    2007-05-01

    Interventional treatment of coronary insufficiency is underemployed among dialysis patients. Studies confirming its efficacy in this set of patients are scarce. To assess the results of interventional treatment of coronary artery disease in patients undergoing dialysis. A total of 34 dialysis patients submitted to coronary angiography between September 1995 and October 2004 were divided according to presence or absence of coronary lesion, type of treatment and presence or absence of diabetes mellitus. The groups were compared according to their clinical and survival characteristics. Survival of patients undergoing interventional treatment was compared to overall survival of 146 dialysis patients at the institution in the same period. Interventional treatment was indicated to the same clinical conditions in the general population. Thirteen patients with no angiography coronary lesions presented a survival rate of 100% in 48 months as compared to 35% of 21 patients with coronary artery disease. Diabetic patients had a lower survival rate compared with non-diabetics. Angioplasty had a worse prognosis compared to surgery; however, 80% of patients undergoing angioplasty were diabetic. Seventeen patients submitted to interventional procedures presented a survival rate similar to that of the others 146 hemodialysis patients without clinical evidence of coronary disease. This small series shows that myocardial revascularization, whenever indicated, can be performed in dialysis patients. This conclusion is corroborated by similar mortality rates in two groups of patients: coronary patients submitted to revascularization and overall dialysis patients.

  5. Das Blüte-Bestäuber-Netz auf Brachflächen : biozönologische Untersuchung zur Bedeutung von Brachen in einer intensiv genutzten Agrarlandschaft

    NASA Astrophysics Data System (ADS)

    Hahn, Robert

    2002-11-01

    In der vorliegenden Dissertation wird die Bedeutung von Brachen für Artenvielfalt und Stabilität von Blüte-Bestäuber-Nahrungsnetzen in agrarisch genutzten Landschaften anhand ausgewählter blütenbesuchender Insektengruppen (Syrphidae, Lepidoptera) untersucht. Die Freilandarbeiten fanden von 1998-2000 im Raum der Feldberger Seenlandschaft, Mecklenburg-Vorpommern, statt. Es werden die beiden Hauptnahrungsquellen Nektar und Pollen betrachtet, dabei fanden Untersuchungen zur Intensität der Blüte-Bestäuber-Interaktion auf Stilllegungsflächen, zum flächenbezogenen quantitativen Nektarangebot im Jahresverlauf, zur individuellen Pollennutzung bei Syrphiden und zur Breite und Überlappung der Nahrungsnischen bei den dominanten Arten Episyrphus balteatus, Metasyrphus corollae, Syritta pipiens und Sphaerophoria scripta statt. Im Ergebnis zeigt sich eine hohe Bedeutung der Brachflächen für die Stabilität des Blüte-Bestäuber-Netzes, während die Diversität von anderen, eher landschaftsbezogenen Faktoren abhängig ist. This dissertation examines the importance of fallow land for the diversity and stability of pollination webs in agricultural landscapes as exemplified by selected groups of anthophilous insects (syrphidae and lepidoptera). The field studies were carried out between 1998 and 2000 in the Feldberg lakeland area in the north-east German State of Mecklenburg-Western Pomerania. Observations were made of nectar and pollen as the two main sources of food. Studies were conducted into the intensity of plant-pollinator interaction in set-aside areas, the site-specific quantity of nectar available during the vegetation period and the individual pollen intake of syrphid flies. Different methods were employed to establish the breadth of the trophic niches among the predominant species (Episyrphus balteatus, Metasyrphus corollae, Syritta pipiens and Sphaerophoria scripta) and the extent to which they overlapped. The studies showed that, while fallow land is very important for the stability of plant-pollinator food webs, their diversity depends on other factors that are more closely related to the landscape.

  6. X Marks the Spot--Not: Pirate Treasure Maps in "Treasure Island" and "Käpt'n Sharky und das Geheimnis der Schatzinsel"

    ERIC Educational Resources Information Center

    Zähringer, Raphael

    2017-01-01

    This article explores the functions of paratextual and intra-textual pirate treasure maps in works of literature for children and young adults. Based on an examination of how the indexical X that "marks the spot" operates as the focal point of the semiotic endeavours of treasure maps, the article outlines the fragile stance of maps…

  7. Elektroninės cigaretės: naujas būdas mesti rūkyti ar nauja grėsmė?

    PubMed Central

    Aistė, Aleknaitė; Monika, Andrijauskaitė; Justė, Latauskienė; Viktorija, Andrejevaitė

    2016-01-01

    Nuo 2010 m. tarp suaugusiųjų ir paauglių išaugo elektroninių cigarečių vartojimas. Dauguma el. cigarečių vartotojų anksčiau yra rūkę tradicinius tabako gaminius. Didžioji dalis žmonių el. cigaretes suvokia kaip priemonę, padėsiančią mesti rūkyti ar sumažinti surūkomų įprastinių cigarečių kiekį. Elektroninės cigaretės yra prietaisas, susidedantis iš skysčiu užpildytos kasetės, kaitiklio bei baterijos. Nuspaudus mygtuką įjungiamas kaitiklis, kuris šildo skystį, o, šiam tapus garais, jie įkvepiami. Visų rūšių el. skysčių pagrindinės sudedamosios dalys yra glicerolis arba propileno glikolis, papildomai gali būti pridedama nikotino ir / ar aromatų. Skysčiuose taip pat nustatyta įvairių kitų cheminių medžiagų. Ilgalaikio el. cigarečių vartojimo pasekmės sveikatai nėra išaiškintos, manoma, kad jos turėtų būti saugesnės nei rūkyti įprastines cigaretes. Nėra pakankamai ištirtas el. cigarečių skysčiuose esančių medžiagų toksiškumas. Trūksta duomenų apie el. cigarečių, kaip pagalbinės priemonės norint mesti rūkyti, veiksmingumą ir saugumą. Gydytojas norinčiam mesti rūkyti pacientui pirmiausia turėtų pasiūlyti patvirtintas pakaitinės nikotino terapijos ar kitas pagalbines priemones ir užtikrinti, kad pacientas gautų informaciją apie naujausius medikamentus, galinčius jam padėti. Jei pacientas atsisako šių priemonių ir renkasi el. cigaretes, gydytojas turėtų informuoti apie abejotiną jų saugumą ir veiksmingumą. Visuomenėje kyla susirūpinimas, kad el. cigarečių rūkymas gali paskatinti priklausomybę nikotinui ir padidinti norą išbandyti įprastines cigaretes. Nerimą kelia ir neapribotas el. cigarečių vartojimas viešosiose vietose. Nėra žinoma, kokią įtaką aplinkinių sveikatai gali turėti pasyvus garinimas. El. cigarečių reglamentavimas visame pasaulyje skiriasi ir laikui bėgant kinta. PMID:28356791

  8. Axisymmetric rotational stagnation point flow impinging radially a permeable stretching/shrinking surface in a nanofluid using Tiwari and Das model

    PubMed Central

    Roşca, Natalia C.; Pop, Ioan

    2017-01-01

    In this paper, the problem of normal impingement rotational stagnation-point flow on a radially permeable stretching sheet in a viscous fluid, recently studied in a very interesting paper, is extended to a water-based nanofluid. A similarity transformation is used to reduce the system of governing nonlinear partial differential equations to a system of ordinary differential equations, which is then solved numerically using the function bvp4c from Matlab. It is found that dual (upper and lower branch) solutions exist for some values of the governing parameters. From the stability analysis, it is found that the upper branch solution is stable, while the lower branch solution is unstable. Sample velocity and temperature profiles along both solution branches are graphically presented. PMID:28079124

  9. Comment on `Magnitude conversion problem using general orthogonal regression' by H. R. Wason, Ranjit Das and M. L. Sharma, (Geophys. J. Int., 190, 1091-1096)

    NASA Astrophysics Data System (ADS)

    Gasperini, Paolo; Lolli, Barbara

    2014-01-01

    The argument proposed by Wason et al. that the conversion of magnitudes from a scale (e.g. Ms or mb) to another (e.g. Mw), using the coefficients computed by the general orthogonal regression method (Fuller) is biased if the observed values of the predictor (independent) variable are used in the equation as well as the methodology they suggest to estimate the supposedly true values of the predictor variable are wrong for a number of theoretical and empirical reasons. Hence, we advise against the use of such methodology for magnitude conversions.

  10. Folgen des Globalen Wandels für das Grundwasser in Süddeutschland - Teil 2: Sozioökonomische Aspekte

    NASA Astrophysics Data System (ADS)

    Barthel, Roland; Krimly, Tatjana; Elbers, Michael; Soboll, Anja; Wackerbauer, Johann; Hennicker, Rolf; Janisch, Stephan; Reichenau, Tim G.; Dabbert, Stephan; Schmude, Jürgen; Ernst, Andreas; Mauser, Wolfram

    2011-12-01

    In order to account for complex interactions between humans climate and the water cycle, the research consortium GLOWA-Danube (www.glowa-danube.de) has developed the simulation system DANUBIA which consists of 17 coupled models. DANUBIA was applied to investigate various impacts of global-change between 2011 and 2060 in the Upper Danube Catchment. This article describes part 2 of an article series with investigations of socio-economic aspects, while part 1 (Barthel et al. in Grundwasser 16(4), doi:10.1007/s007-011-01794, 2011) deals with natural-spatial aspects. The principles of socio-economic actor-modeling and interactions between socio-economic and natural science model components are described here. We present selected simulations that show impacts on groundwater from changes in agriculture, tourism, economy, domestic water users and water supply. Despite decreases in water consumption, the scenario simulations show significant decreases in groundwater quantity. On the other hand, groundwater quality will likely be influenced more severely by land use changes compared to direct climatic causes. However, overall changes will not be dramatic.

  11. Folgen des Globalen Wandels für das Grundwasser in Süddeutschland - Teil 1: Naturräumliche Aspekte

    NASA Astrophysics Data System (ADS)

    Barthel, Roland; Reichenau, Tim G.; Muerth, Markus; Heinzeller, Christoph; Schneider, Karl; Hennicker, Rolf; Mauser, Wolfram

    2011-12-01

    In order to account for complex interactions between humans climate and the water cycle, the research consortium GLOWA-Danube (www.glowa-danube.de) has developed the simulation system DANUBIA which consists of 17 coupled models. DANUBIA was applied to investigate various impacts of global-change between 2011 and 2060 in the Upper Danube Catchment. This article represents part 1 of an article series and describes groundwater and natural aspects of the investigations, while part 2 describes socio-economic aspects (Barthel et al. in Grundwaser 16(4), doi:10.1007/s00767-011-0180-y, 2011). Here we describe concepts of GLOWA-Danube and DANUBIA as well as groundwater-related model components. This leads to selected simulation results for water balance, groundwater quantity and quality. The chosen scenarios show decreasing precipitation, increasing temperatures, and changes in the annual distribution that lead to significant decreases in groundwater recharge. Regional predictions of groundwater quality were difficult to achieve because of complex soil and groundwater processes. However, climatic change will probably have little impact.

  12. "Der Andere" und "Das Andere" als Problem und Aufgabe von Erziehung und Bildung ("The Other Individual" and "The Other" as a Problem and a Task of Education).

    ERIC Educational Resources Information Center

    Benner, Dietrich

    1999-01-01

    Examines the common division in pedagogical discourse of the other as either (1) male or female individual or (2) the world beyond the subject. Proposes an approach that examines both forms of otherness in relation to each other. Addresses the significance for pedagogical theory and practice. (CMK)

  13. Proceedings of the NATO Advanced Study Institute on Atmospheric Ozone: Its Variation and Human Influences, Aldeia das Acoteias, Algarve, Portugal, October 1-13, 1979,

    DTIC Science & Technology

    1980-05-01

    conditions, J. Geophys. Res., 82, 5923-5927, 1977. Hameed, S., J. P. Pinto and R. W. Stewart, Sensitivity of the predicted CO-OH-CH4 perturba- tion to...Systems of the World, Cambridge University Press, 1974. Hameed, S., J.P. Pinto , R.W. Stewart, Sensitivity of the Predicted CO-OH-CH4 Perturbation to...sensitized decomposition of 03: The reactions of CIO and 0CZO with 031 J. Photochem. 10, 163-186, 1979. 465 WATSON Yung, Y. L., P. J. Pinto , R. T

  14. "About the Telescope" and other manuscripts of lectures by Christoph Scheiner. (German Title: "Über das Fernrohr" und weitere Mitschriften von Vorlesungen Christoph Scheiners)

    NASA Astrophysics Data System (ADS)

    Daxecker, Franz

    "About the Telescope" is a manuscript of a lecture which was held by Christoph Scheiner in Ingolstadt around 1615. It has been translated from Latin. The manuscript gives an account of the invention, the construction, the manufacture and the use of the telescope. There is also a reference to 3 more manuscripts (19 topics about astronomy and physics) of his lectures.

  15. Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) - short version.

    PubMed

    Baron, Ralf; Binder, Andreas; Biniek, Rolf; Braune, Stephan; Buerkle, Hartmut; Dall, Peter; Demirakca, Sueha; Eckardt, Rahel; Eggers, Verena; Eichler, Ingolf; Fietze, Ingo; Freys, Stephan; Fründ, Andreas; Garten, Lars; Gohrbandt, Bernhard; Harth, Irene; Hartl, Wolfgang; Heppner, Hans-Jürgen; Horter, Johannes; Huth, Ralf; Janssens, Uwe; Jungk, Christine; Kaeuper, Kristin Maria; Kessler, Paul; Kleinschmidt, Stefan; Kochanek, Matthias; Kumpf, Matthias; Meiser, Andreas; Mueller, Anika; Orth, Maritta; Putensen, Christian; Roth, Bernd; Schaefer, Michael; Schaefers, Rainhild; Schellongowski, Peter; Schindler, Monika; Schmitt, Reinhard; Scholz, Jens; Schroeder, Stefan; Schwarzmann, Gerhard; Spies, Claudia; Stingele, Robert; Tonner, Peter; Trieschmann, Uwe; Tryba, Michael; Wappler, Frank; Waydhas, Christian; Weiss, Bjoern; Weisshaar, Guido

    2015-01-01

    In 2010, under the guidance of the DGAI (German Society of Anaesthesiology and Intensive Care Medicine) and DIVI (German Interdisciplinary Association for Intensive Care and Emergency Medicine), twelve German medical societies published the "Evidence- and Consensus-based Guidelines on the Management of Analgesia, Sedation and Delirium in Intensive Care". Since then, several new studies and publications have considerably increased the body of evidence, including the new recommendations from the American College of Critical Care Medicine (ACCM) in conjunction with Society of Critical Care Medicine (SCCM) and American Society of Health-System Pharmacists (ASHP) from 2013. For this update, a major restructuring and extension of the guidelines were needed in order to cover new aspects of treatment, such as sleep and anxiety management. The literature was systematically searched and evaluated using the criteria of the Oxford Center of Evidence Based Medicine. The body of evidence used to formulate these recommendations was reviewed and approved by representatives of 17 national societies. Three grades of recommendation were used as follows: Grade "A" (strong recommendation), Grade "B" (recommendation) and Grade "0" (open recommendation). The result is a comprehensive, interdisciplinary, evidence and consensus-based set of level 3 guidelines. This publication was designed for all ICU professionals, and takes into account all critically ill patient populations. It represents a guide to symptom-oriented prevention, diagnosis, and treatment of delirium, anxiety, stress, and protocol-based analgesia, sedation, and sleep-management in intensive care medicine.

  16. Das Bin Ich. Ein Buch von mir uber mich (It's Me! A Book By and About Myself). Communicative Activities for German Immersion and Second Language Classes.

    ERIC Educational Resources Information Center

    Wicke, Mariele; Wicke, Rainer

    This workbook is intended as a text for the learner of German as a foreign language. The workbook is complete with exercises that require students to provide information about themselves. Students provide information by reading questions and filling in the blanks. Questions are asked about families, friends, likes and dislikes, hobbies, and even…

  17. Kooperatives Lernen lernen? Zur Diskussion uber das Bildungswesen in Japan (Learning Cooperative Learning? On the Discussion of the Japanese Educational System).

    ERIC Educational Resources Information Center

    Schubert, Volker

    1998-01-01

    Suggests a reconsideration of the criticism of Japanese competition against the background of the Japanese educational system's highly developed learning culture. Considers some of the basic aspects of group-oriented communal learning in school, while also cautioning against a "monocausal" culturalism. (Author/CMK)

  18. Das Bin Ich. Ein Buch von mir uber mich (It's Me! A Book By and About Myself). Communicative Activities for German Immersion and Second Language Classes.

    ERIC Educational Resources Information Center

    Wicke, Mariele; Wicke, Rainer

    This workbook is intended as a text for the learner of German as a foreign language. The workbook is complete with exercises that require students to provide information about themselves. Students provide information by reading questions and filling in the blanks. Questions are asked about families, friends, likes and dislikes, hobbies, and even…

  19. Kooperatives Lernen lernen? Zur Diskussion uber das Bildungswesen in Japan (Learning Cooperative Learning? On the Discussion of the Japanese Educational System).

    ERIC Educational Resources Information Center

    Schubert, Volker

    1998-01-01

    Suggests a reconsideration of the criticism of Japanese competition against the background of the Japanese educational system's highly developed learning culture. Considers some of the basic aspects of group-oriented communal learning in school, while also cautioning against a "monocausal" culturalism. (Author/CMK)

  20. Our Day-Care Centers Respect Children: Quality Criteria for Day-Care = Criterios para um Atendimento em Creches que Respeite os Direitos Fundamentais das Criancas.

    ERIC Educational Resources Information Center

    Campos, Maria Malta; Rosemberg, Fulvia

    Prepared as part of an effort to attain minimum quality standards for Brazilian day care centers, this document focuses on day-to-day provision of day care services for children from birth to 6 years old as well as broader day care administrative concerns. The first version of this document was prepared as part of a training project for day care…

  1. Immunodetection of Triticum mosaic virus by DAS- and DAC-ELISA using antibodies produced against coat protein expressed in Escherichia coli: potential for high-throughput diagnostic methods.

    PubMed

    Tatineni, Satyanarayana; Sarath, Gautam; Seifers, Dallas; French, Roy

    2013-04-01

    Triticum mosaic virus (TriMV), an economically important virus infecting wheat in the Great Plains region of the USA, is the type species of the Poacevirus genus in the family Potyviridae. Sensitive and high-throughput serology-based detection methods are crucial for the management of TriMV and germplasm screening in wheat breeding programs. In this study, TriMV coat protein (CP) was expressed in Escherichia coli, and polyclonal antibodies were generated against purified soluble native form recombinant CP (rCP) in rabbits. Specificity and sensitivity of resulting antibodies were tested in Western immuno-blot and enzyme-linked immunosorbent assays (ELISA). In direct antigen coating (DAC)-ELISA, antibodies reacted specifically, beyond 1:20,000 dilution with TriMV in crude sap, but not with healthy extracts, and antiserum at a 1:10,000 dilution detected TriMV in crude sap up to 1:4860 dilution. Notably, rabbit anti-TriMV IgG and anti-TriMV IgG-alkaline phosphatase conjugate reacted positively with native virions in crude sap in a double antibody sandwich-ELISA, suggesting that these antibodies can be used as coating antibodies which is crucial for any 'sandwich' type of assays. Finally, the recombinant antibodies reacted positively in ELISA with representative TriMV isolates collected from fields, suggesting that antibodies generated against rCP can be used for sensitive, large-scale, and broad-spectrum detection of TriMV.

  2. Molecular characterization of van genes found in vancomycin-resistant Enterococcus spp. isolated from the Hospital das Clínicas, FMUSP, São Paulo, Brazil.

    PubMed

    Caiaffa Filho, H H; Almeida, G D; Oliveira, G A; Sarahyba, L; Mamizuka, E M; Burattini, M N

    2003-06-01

    Vancomycin-resistant enterococci strains (VRE) is an important pathogen related with hospital infections in many countries, presenting limited or no therapeutic options for treating serious infections. VRE has presented some different genotypes been VanA and VanB considered to be the most important in hospital environments. In the present study the authors investigated the prevalence of van genes (A, B an C) among clinical isolates of VRE in a five month period at a large tertiary hospital in Sao Paulo, Brazil. The results showed the presence of vanA, but not vanB or vanC in all 43 strains of E. faecalis and five E. faecium studied. The results bring an important issue, due to the possibility of resistance spread of vanA genes, to be monitored and solved by the hospital infection control team and the microbiology and molecular biology laboratories at tertiary Hospitals.

  3. Educational Planning and Management in Small States [and] De la viabilite au developpement durable: role et perpectives de la planification de l'education das les petits Etates.

    ERIC Educational Resources Information Center

    Bray, Mark; Atchoarena, David

    Part of Round Table IV, this document consists of two articles presented at an international congress in Mexico. Each deals with planning and management of education in small countries. The purpose of the congress was to review the evolution of educational planning and management since a previous conference held in 1968. The participants hoped to…

  4. Antarktis: Das CCAMLR-Übereinkommen (Convention on the Conservation of Antarctic Marine Living Resources) und die illegale Überfischung der südlichen Ozeane

    NASA Astrophysics Data System (ADS)

    Siegel, Volker

    1999-12-01

    The Convention for the Conservation of Antarctic Marine Living Resources (CCAMLR) was ratified in 1982. This Convention was established in the light of a rapidly developing krill fishery in the 1970’s. The objectives of the Convention are the rational use of marine living resources as well as the conservation of the resources and the marine ecosystem. Establishing the principle of the ecosystem approach has been rather progressive in fisheries conventions. From the bery beginning CCAMLR had to deal with problems of over-exploited fish stock from the unregulated fishery of pre-CCAMLR times. Antarctic cod and icefish stock were already heavily harvested or even showed signs of overfishing. Conservation measures and the closure of subareas for several years did not always lead to satisfactorily results. While some stock of icefish recovered to the extent, that a new fishery on a low level could be re-opened, other icefish stocks and especially Antarctic cod stocks have not recovered from this early depletion. A new dimension in the fishery developed in the mid 1990’s, when very conservative conservation measures were introduced for the Dissostichus (toothfish), but due to the high commercial value a large illegal fishery developed rapidly in the Convention area. One additional problem of managing the longline fishery for toothfish is the by-catch and incidental mortality of sea-birds, for which special measures were established to avoid sea-bird mortality. The compliance with the measures and the elimination of the illegal fishery require strong actions of the Commission, the political decision-making body of CCAMLR. A future challange for CCAMLR could be the potentially expanding krill fishery. In the understanding of a precautionary approach, the scientific body of CCAMLR has already started to collect biological data and develop management and monitoring models for this fishery.

  5. Tão perto de casa, tão longe de nós: etnografia das novas margens no centro da urbe

    PubMed Central

    Fernandes, Por Luís

    2011-01-01

    Philippe Bourgois é, desde 2007, “Richard Perry University professor” no Departamento de Antropologia e de Medicina Familiar e de Práticas Comunitárias na Universidade da Pensilvânia. Esteve durante largos anos ligado ao Departamento de Antropologia, História e Medicina Social da Universidade da Califórnia, São Francisco. A publicação, em 1995, de In Search of Respect: Selling Crack in El Barrio1 projectaria o seu nome muito para além dos Estados Unidos: uma etnografia no coração porto-riquenho do Harlem, em torno dos actores e dos ambientes da venda de crack. Seguir-se-ia um longo trabalho de terreno em acampamentos de dependentes de heroína em São Francisco, orientando o seu trabalho para as formas mais radicais da pobreza e da marginalidade nos EUA. É deste trabalho de terreno que sai o seu último livro, Righteous Dopefiend2. Em Junho de 2007 esteve em Lisboa para participar na 3.a edição do “Ethnografeast”. Foi então que aproveitámos a oportunidade para ouvir um percurso invulgar contado pelo próprio: uma longa conversa no Hotel Zurique, cujo nome só vem ao caso por evocar o país onde passou uma parte da infância. PMID:22013286

  6. THE ALCOHOL CONSUMPTION IS AMENDED AFTER BARIATRIC SURGERY? AN INTEGRATIVE REVIEW.

    PubMed

    Gregorio, Valeria Duarte; Lucchese, Roselma; Vera, Ivânia; Silva, Graciele C; Silva, Andrecia; Moraes, Rayrane Clarah Chaveiro

    Bariatric surgery has been an alternative when conservative methods of weight loss fail. Patients undergoing bariatric surgery have an increased risk of up to 6.5% of problems related to alcohol. Integrative review out to analyze the change of alcohol consumption in this public. Database was accessed from June of 2015 to January of 2016 by searching "bariatric surgery" AND "alcoholism", and their Portuguese equivalents. ScienceDirect, PubMed, Lilacs and Medline, besides manual search, were searched. To be included, the paper should have been published between 2005-2016 and related to bariatric surgery and alcoholism. Theses, dissertations, unpublished papers, case reports and theoretical studies were excluded, and a database was subsequently composed. In 2005 there was only a review of change in alcohol metabolism in patients undergoing bariatric surgery. There were no publications in 2006. In 2007, only one study was published, and it did not meet the inclusion criteria. In 2010, there was an increase of 13% in publications and of 20% in 2012, reaching 40% in 2013. The prevalence and incidence of alcohol consumption in relation to the postoperative time was six months to three years with higher incidence for follow-up treatment by men. Roux-en-Y gastric bypass showed greater association with increased consumption of alcohol during the postoperative period. Alcohol consumption proved to be essential to be faced in bariatric surgery. A cirurgia bariátrica tem-se mostrado alternativa para o insucesso dos métodos conservadores de emagrecimento. Pacientes submetidos a ela têm 6,5% aumento do risco de terem problemas relacionados ao álcool. Realizar revisão integrativa para verificar alteração do consumo de álcool neste publico. A base de dados Science Direct, PubMed, Lilacs, Medline e busca manual foram acessadas entre os meses de junho de 2015 a janeiro de 2016 com os descritores "cirurgia bariátrica" e "alcoolismo" e equivalentes em inglês Os critérios de

  7. [Conservative management of tracheal rupture in a child after blunt trauma].

    PubMed

    Kucuk, Gonul; Ates, Ufuk; Gollu, Gulnur; Yagmurlu, Aydin

    2016-12-01

    La rotura traqueal tras una contusión es rara, aunque potencialmente mortal. En general, se recomienda el tratamiento quirúrgico para la rotura traqueal, aunque también se ha informado recientemente el abordaje conservador en los pacientes con signos vitales y parámetros respiratorios estables. El objetivo de este estudio es informar sobre un caso de rotura traqueal tras una contusión en el cuello producto de un accidente de bicicleta que se trató de manera conservadora. Sociedad Argentina de Pediatría.

  8. BIODEGRADABLE BILIARY STENTS: A NEW APPROACH FOR THE MANAGEMENT OF HEPATICOJEJUNOSTOMY STRICTURES FOLLOWING BILE DUCT INJURY. PROSPECTIVE STUDY.

    PubMed

    Giménez, Mariano E; Palermo, Mariano; Houghton, Eduardo; Acquafresca, Pablo; Finger, Caetano; Verde, Juan M; Cúneo, Jorge Cardoso

    2016-01-01

    Once a biliary injury has occurred, repair is done by a hepaticojejunostomy. The most common procedure is to perform a dilatation with balloon with a success of 70 %. Success rates range using biodegradable stents is from 85% to 95%. Biodegradable biliary stents should change the treatment of this complication. To investigate the use of biodegradable stents in a group of patients with hepaticojejunonostomy strictures. In a prospective study 16 biodegradable stents were placed in 13 patients with hepaticojejunostomy strictures secondary to bile duct repair of a biliary surgical injury. Average age was 38.7 years (23-67), nine were female and four male. All cases had a percutaneous drainage before at the time of biodegradable stent placement. In one case, temporary haemobilia was present requiring blood transfusion. In another, pain after stent placement required intravenous medication. In the other 11 patients, hospital discharge was the next morning following stent placement. During the patient´s follow-up, none presented symptoms during the first nine months. One patient presented significant alkaline phosphatase elevation and stricture recurrence was confirmed. One case had recurrence of cholangitis 11 months after the stent placement. 84.6% continued asymptomatic with a mean follow-up of 20 months. The placement of biodegradable stents is a safe and feasible technique. Was not observed strictures caused by the stent or its degradation. It could substitute balloon dilation in strictures of hepaticojejunostomy. Uma vez que lesão biliar ocorreu, o reparo é feito por hepaticojejunostomia. O procedimento mais comum é efetuar dilatação com balão com sucesso de 70%. As taxas de sucesso utilizando stents biodegradáveis ​​é de 85% a 95%. Stents biliares biodegradáveis ​​devem mudar o tratamento desta complicação. Investigar o uso de stents biodegradáveis em um grupo de pacientes com estenose hepaticojejunal. Em estudo prospectivo 16 stents biodegrad

  9. Patterns of Strengths and Weaknesses on the WISC-V, DAS-II, and KABC-II and Their Relationship to Students' Errors in Oral Language, Reading, Writing, Spelling, and Math

    ERIC Educational Resources Information Center

    Breaux, Kristina C.; Avitia, Maria; Koriakin, Taylor; Bray, Melissa A.; DeBiase, Emily; Courville, Troy; Pan, Xingyu; Witholt, Thomas; Grossman, Sandy

    2017-01-01

    This study investigated the relationship between specific cognitive patterns of strengths and weaknesses and the errors children make on oral language, reading, writing, spelling, and math subtests from the Kaufman Test of Educational Achievement-Third Edition (KTEA-3). Participants with scores from the KTEA-3 and either the Wechsler Intelligence…

  10. Psychometric evaluation of the SF-36 (v.2) questionnaire in a probability sample of Brazilian households: results of the survey Pesquisa Dimensões Sociais das Desigualdades (PDSD), Brazil, 2008.

    PubMed

    Laguardia, Josué; Campos, Monica R; Travassos, Claudia M; Najar, Alberto L; Anjos, Luiz A; Vasconcellos, Miguel M

    2011-08-03

    In Brazil, despite the growing use of SF-36 in different research environments, most of the psychometric evaluation of the translated questionnaire was from studies with samples of patients. The purpose of this paper is to examine if the Brazilian version of SF-36 satisfies scaling assumptions, reliability and validity required for valid interpretation of the SF-36 summated ratings scales in the general population. 12,423 individuals and their spouses living in 8,048 households were selected from a stratified sample of all permanent households along the country to be interviewed using the Brazilian SF-36 (version 2). Psychometric tests were performed to evaluate the scaling assumptions based on IQOLA methodology. Data quality was satisfactory with questionnaire completion rate of 100%. The ordering of the item means within scales clustered as hypothesized. All item-scale correlations exceeded the suggested criteria for reliability with success rate of 100% and low floor and ceiling effects. All scales reached the criteria for group comparison and factor analysis identified two principal components that jointly accounted for 67.5% of the total variance. Role emotional and vitality were strongly correlated with physical and mental components, respectively, while social functioning was moderately correlated with both components. Role physical and mental health scales were, respectively, the most valid measures of the physical and mental health component. In the comparisons between groups that differed by the presence or absence of depression, subjects who reported having the disease had lower mean scores in all scales and mental health scale discriminated best between the two groups. Among those healthy and with one, two or three and more chronic illness, the average scores were inverted related to the number of diseases. Body pain, general health and vitality were the most discriminating scales between healthy and diseased groups. Higher scores were associated with individuals of male sex, age below 40 years old and high schooling. The Brazilian version of SF-36 performed well and the findings suggested that it is a reliable and valid measure of health related quality of life among the general population as well as a promising measure for research on health inequalities in Brazil.

  11. Psychometric evaluation of the SF-36 (v.2) questionnaire in a probability sample of Brazilian households: results of the survey Pesquisa Dimensões Sociais das Desigualdades (PDSD), Brazil, 2008

    PubMed Central

    2011-01-01

    Background In Brazil, despite the growing use of SF-36 in different research environments, most of the psychometric evaluation of the translated questionnaire was from studies with samples of patients. The purpose of this paper is to examine if the Brazilian version of SF-36 satisfies scaling assumptions, reliability and validity required for valid interpretation of the SF-36 summated ratings scales in the general population. Methods 12,423 individuals and their spouses living in 8,048 households were selected from a stratified sample of all permanent households along the country to be interviewed using the Brazilian SF-36 (version 2). Psychometric tests were performed to evaluate the scaling assumptions based on IQOLA methodology. Results Data quality was satisfactory with questionnaire completion rate of 100%. The ordering of the item means within scales clustered as hypothesized. All item-scale correlations exceeded the suggested criteria for reliability with success rate of 100% and low floor and ceiling effects. All scales reached the criteria for group comparison and factor analysis identified two principal components that jointly accounted for 67.5% of the total variance. Role emotional and vitality were strongly correlated with physical and mental components, respectively, while social functioning was moderately correlated with both components. Role physical and mental health scales were, respectively, the most valid measures of the physical and mental health component. In the comparisons between groups that differed by the presence or absence of depression, subjects who reported having the disease had lower mean scores in all scales and mental health scale discriminated best between the two groups. Among those healthy and with one, two or three and more chronic illness, the average scores were inverted related to the number of diseases. Body pain, general health and vitality were the most discriminating scales between healthy and diseased groups. Higher scores were associated with individuals of male sex, age below 40 years old and high schooling. Conclusions The Brazilian version of SF-36 performed well and the findings suggested that it is a reliable and valid measure of health related quality of life among the general population as well as a promising measure for research on health inequalities in Brazil. PMID:21812986

  12. Das US-Fachinformationssystem ERIC und die Entwicklung eines Fachinformationssystems Bildung in der Bundesrepublik Deutschland (The American Subject Information System ERIC and the Development of an Information System on Education in the German Federal Republic).

    ERIC Educational Resources Information Center

    Nachrichten fur Dokumentation, 1982

    1982-01-01

    In order to further develop West German information services for education, it is suggested that the ERIC structural model--a coordinating central office and a network of clearinghouses--be developed as a continuation of the existing "Dokumentationsring Padagogik" (DOPAED) documentation service. (16 references) (EJS)

  13. Biologie und Fremdsprachenunterricht. Das Prinzip der Einsprachigkeit im Lichte biologischer Erkenntnisse ueber Denken und Lernen (Biology and Foreign Language Teaching. The Monolingual Principle in the Light of Biological Findings concerning Thinking and Learning).

    ERIC Educational Resources Information Center

    Schneider, Rudolf

    1979-01-01

    Draws upon recent publications dealing with brain function (particularly F. Vester, "Denken, Lernen, Vergessen", Munich, 1978) for ideas for foreign language teaching. These include constant use of the foreign language in the classroom, frequent repetition, and avoidance of false associations by explanation in the native language.…

  14. Patterns of Strengths and Weaknesses on the WISC-V, DAS-II, and KABC-II and Their Relationship to Students' Errors in Oral Language, Reading, Writing, Spelling, and Math

    ERIC Educational Resources Information Center

    Breaux, Kristina C.; Avitia, Maria; Koriakin, Taylor; Bray, Melissa A.; DeBiase, Emily; Courville, Troy; Pan, Xingyu; Witholt, Thomas; Grossman, Sandy

    2017-01-01

    This study investigated the relationship between specific cognitive patterns of strengths and weaknesses and the errors children make on oral language, reading, writing, spelling, and math subtests from the Kaufman Test of Educational Achievement-Third Edition (KTEA-3). Participants with scores from the KTEA-3 and either the Wechsler Intelligence…

  15. Lehrer in der Bundesrepublik Deutschland. Eine Kritische Analyse Statistischer Daten uber das Lehrpersonal an Allgemeinbildenden Schulen. (Education in the Federal Republic of Germany. A Statistical Study of Teachers in Schools of General Education.)

    ERIC Educational Resources Information Center

    Kohler, Helmut

    The purpose of this study was to analyze the available statistics concerning teachers in schools of general education in the Federal Republic of Germany. An analysis of the demographic structure of the pool of full-time teachers showed that in 1971 30 percent of the teachers were under age 30, and 50 percent were under age 35. It was expected that…

  16. Efficacy of the Herpes Simplex Virus 2 (HSV-2) Glycoprotein D/AS04 Vaccine against Genital HSV-2 and HSV-1 Infection and Disease in the Cotton Rat Sigmodon hispidus Model

    PubMed Central

    McKay, Jamall; Mbaye, Aissatou; Sanford-Crane, Hannah; Blanco, Jorge C. G.; Huber, Ashley; Herold, Betsy C.

    2015-01-01

    ABSTRACT Subunit vaccines based on the herpes simplex virus 2 (HSV-2) glycoprotein D (gD-2) have been the major focus of HSV-2 vaccine development for the past 2 decades. Based on the promising data generated in the guinea pig model, a formulation containing truncated gD-2, aluminum salt, and MPL (gD/AS04) advanced to clinical trials. The results of these trials, however, were unexpected, as the vaccine protected against HSV-1 infection but not against HSV-2. To address this discrepancy, we developed a Depot medroxyprogesterone acetate (DMPA)-treated cotton rat Sigmodon hispidus model of HSV-2 and HSV-1 genital infection. The severity of HSV-1 genital herpes was less than that of HSV-2 genital herpes in cotton rats, and yet the model allowed for comparative evaluation of gD/AS04 immunogenicity and efficacy. Cotton rats were intramuscularly vaccinated using a prime boost strategy with gD/AS04 (Simplirix vaccine) or control vaccine formulation (hepatitis B vaccine FENDrix) and subsequently challenged intravaginally with HSV-2 or HSV-1. The gD/AS04 vaccine was immunogenic in cotton rats and induced serum IgG directed against gD-2 and serum HSV-2 neutralizing antibodies but failed to efficiently protect against HSV-2 disease or to decrease the HSV-2 viral load. However, gD/AS04 significantly reduced vaginal titers of HSV-1 and better protected animals against HSV-1 compared to HSV-2 genital disease. The latter finding is generally consistent with the clinical outcome of the Herpevac trial of Simplirix. Passive transfer of serum from gD/AS04-immunized cotton rats conferred stronger protection against HSV-1 genital disease. These findings suggest the need for alternative vaccine strategies and the identification of new correlates of protection. IMPORTANCE In spite of the high health burden of genital herpes, there is still no effective intervention against the disease. The significant gap in knowledge on genital herpes pathogenesis has been further highlighted by the recent failure of GSK HSV-2 vaccine Simplirix (gD/AS04) to protect humans against HSV-2 and the surprising finding that the vaccine protected against HSV-1 genital herpes instead. In this study, we report that gD/AS04 has higher efficacy against HSV-1 compared to HSV-2 genital herpes in the novel DMPA-synchronized cotton rat model of HSV-1 and HSV-2 infection. The findings help explain the results of the Simplirix trial. PMID:26178984

  17. Georg Philipp Harsdörffer, the first astronomical card game, and the Christian constellations (German Title: Georg Philipp Harsdörffer, das erste astronomische Kartenspiel und die christlichen Sternbilder)

    NASA Astrophysics Data System (ADS)

    Gaab, Hans

    The first astronomical card game was issued in Nuremberg in 1656. Its author was the lawyer, writer and literary theoretican Georg Philipp Harsdouml;rffer (1607-1658), who is primarily remembered as the inventor of the “Nuremberg funnel”. It is possible that a second card game was issued in the same year, but the sources are ambiguous. After some preliminaries on the history of card games, Harsdörffer's pack of cards is presented. In addition, general remarks about the history of sky maps are given.

  18. The master and the telescopes - the interplay between astronomy and optics in history (German Title: Der Meister und die Fernrohre - Das Wechselspiel zwischen Astronomie und Optik in der Geschichte)

    NASA Astrophysics Data System (ADS)

    Hamel, Jürgen; Keil, Inge

    The use of the telescope for astronomical observations since 1609 was one of the milestones in the celestial research. The contributions in this volume present new insights into the invention of the telescope and its relations to reading stones and spectacles, present investigations of special telescope types of early manufacturers, and analyze the telescopes of some historical observatories and the investigations carried out with them. Other contributions deal with the pictorial appearance of telescopes in baroque art, the connection of telescopes with photography, as well as the development of reflectors in the 20th century. The volume is dedicated to Rolf Riekher, an internationally established specialist ior the history of the telescope, on the occasion of his 85th birthday.

  19. Freiluftschulen: Eine Historisch-Padagogische Randerscheinung als Reflex Sozial-Historischer Modernisierungsprozesse? Das Beispiel Belgiens (Open-Air Schools: A Marginal Appearance in Pedagogical History as a Reflection of Socio-Historical Processes of Modernization? The Example of Belgium).

    ERIC Educational Resources Information Center

    Depaepe, Marc; Simon, Frank

    2003-01-01

    Discusses the history of open-air schools using an evaluation of Belgian schools. Expounds on the complex relationship between educational space and the educational act, and between traditional and progressive education. Demonstrates that open-air schools provided the same education as traditional schools and were not a real alternative for…

  20. James Baldwin und das Rassenproblem in den USA. Unterrichtsprojekt zum Komplex "Texte und ihre gesellschaftliche Bedingtheit" (James Baldwin and the Race Problem in the USA. Teaching Project in the Series "Texts and their Social Context")

    ERIC Educational Resources Information Center

    Kerschgens, Edda

    1977-01-01

    Reports on an 18-hour teaching project with students at a teachers' college. Four Baldwin texts were used. Questions considered included whether Baldwin's treatment of the race problem reveals any changes or shifts of emphasis. Suggestions are made for adaptation to teaching in grades 11-13. (Text is in German.) (IFS/WGA)

  1. Integrating UHPLC-MS/MS quantification and DAS analysis to investigate the effects of wine-processing on the tissue distributions of bioactive constituents of herbs in rats: Exemplarily shown for Dipsacus asper.

    PubMed

    Tao, Yi; Du, Yingshan; Li, Weidong; Cai, Baochang; Di, Liuqing; Shi, Liyun; Hu, Lihong

    2017-06-15

    Wine-processing, which is sauteing with rice wine, will change the inclination and direction of herbs' actions. After being wine-processed, the effects of nourishing liver and kidney of Dipsacus asper will be strengthened. However, the underlying mechanism remains elusive. The following study is to establish and validate an UHPLC-MS/MS approach to determine six bioactive constituents in tissue samples, including loganin, loganic acid, chlorogenic acid, 3,5-dicaffeoylquinic acid, 4-caffeoylquinic acid and asperosaponin VI and apply the approach to a comparative tissue distribution study of raw and wine-processed Dipsacus asper in rats. A Shimadzu UHPLC system coupled with triple quadrupole mass spectrometer was employed for analysis of the six analytes using multiple reaction monitoring (MRM) mode. A one-step protein precipitation by methanol was employed to extract the six analytes from tissues. Chloramphenicol and glycyrrhetinic acid were selected as internal standards. The proposed approach was fully validated in terms of linearity, sensitivity, precision, repeatability as well as recovery. Our results revealed that all of the calibration curves displayed good linear regression (r(2)>0.9991). Intra- and inter-assay variability for all analytes ranged from -4.62 to 4.93% and from -4.98 to 4.92%, respectively. The recovery rates for each analytes were determined to be 88.3-100.1%. All the samples showed satisfactory precision and accuracy after various stability tests, including storage at 25°C for 4h, -80°C for 30days, three-freeze-thaw cycles, and 4°C for 24h. Tissue pharmacokinetic parameters including AUC0-t, t1/2, Tmax and Cmax were calculated. Collectively, the parameters of Cmax and AUC0-t of the six analytes in wine-processed group were remarkably elevated (p<0.05) in the rat liver and kidney as compared with those of the raw group. But in the rat heart and spleen, the Cmax and AUC0-t of asperosaponin VI was decreased as compared with those of the raw group. The accumulation of bioactive constituents in liver and kidney tissues after wine-processing will contribute to the enhancement of liver and kidney nourishing effects. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. [Discourses and practices concerning the social participation process in health education activities: community mobilization in the PCDEN/PE. Programa de Controle das Doenças Endêmicas do Nordeste/Pernambuco].

    PubMed

    Acioli, M D; de Carvalho, E F

    1998-01-01

    This study analyzes and compares several social participation concepts in health education processes to practical experiences with schistosomiasis prevention measures under the Northeast Endemic Disease Control Program (Brazilian Ministry of Health/World Bank, 1987). Using qualitative methods, institutional documents and discourses were interpreted (Sucam, FNS, and Ministry of Health). A field study was also performed (using interviews with community-based health agents and the general population) in the Zona da Mata region of Pernambuco (a historically endemic area for schistosomiasis), focused in the county of Amaraji. Comparing discourses and educational practices, we found factors that explain respective points of convergence and divergence, as well as elements linked to the social and historical process of the target population which systematically limit the efficacy of such educational measures.

  3. Das Licht am Ende des Tunnels: Motivationsstrukturen fur den Deutschunterricht Reflexionen uber ein altes und stets neues Problem (The Light at the End of the Tunnel: Structures for Motivating German Teaching. Reflections on an Old and Continually New Problem).

    ERIC Educational Resources Information Center

    Classen, Albrecht

    2001-01-01

    Argues that despite the decline in enrollments in German at elementary and secondary schools and colleges and universities, there is reason to hope that interest can be invigorated. Suggests that there are easy instructional methods and materials for developing a new motivation in learning the language. (Author/VWL)

  4. Der Zitier-Index (Science-Citation-Index): Eine Datenbank fur das Ermitteln von neuen Ideen und Konzepten (The Science Citation Index: A Database for the Discovery of New Ideas and Concepts).

    ERIC Educational Resources Information Center

    Simon, Hans-Reiner; Thormann, K.-D.

    This report discusses the use of the Science Citation Index produced by the Institute for Scientific Information (ISI) as a given "expert system" in the experimental study of different search levels. The inquiry has two objectives: (1) to test whether a "traditional" information system will also produce the rudiments of a…

  5. The aerial telescope of Giuseppe Campani in the Astronomical-Physical Cabinet of the Museumslandschaft Hessen Kassel (German Title: Das Luftfernrohr von Giuseppe Campani im Astronomisch-Physikalischen Kabinett der Museumslandschaft Hessen Kassel )

    NASA Astrophysics Data System (ADS)

    Trier, Friedrich H.; Gaulke, Karsten

    Several large-size objective lenses are found in the Astronomical-Physical Cabinet in Cassel, which have aroused several times the interest of specialists in the past. One of them bears the signature “Guiseppe Campani in Roma anno 1684 Palmi 145”. Since G.D. Cassini, the first director of Paris Observatory, discovered several of Saturn's moons and the Cassini division of Saturn's ring with Campani-lenses of similar construction, the cultural value of the Cassel lense is to be estimated highly. Starting from the technique of the aerial telescope, the contribution tries to answer the question which astronomical observations have theoretically been possible with it, and tells the story of the purchase in Rome and the attempts in Cassel to use the aerial telescope for astronomical use even almost 100 years after its construction.

  6. Das Licht am Ende des Tunnels: Motivationsstrukturen fur den Deutschunterricht Reflexionen uber ein altes und stets neues Problem (The Light at the End of the Tunnel: Structures for Motivating German Teaching. Reflections on an Old and Continually New Problem).

    ERIC Educational Resources Information Center

    Classen, Albrecht

    2001-01-01

    Argues that despite the decline in enrollments in German at elementary and secondary schools and colleges and universities, there is reason to hope that interest can be invigorated. Suggests that there are easy instructional methods and materials for developing a new motivation in learning the language. (Author/VWL)

  7. Kindern das Wort geben: Ein interkulturell-kreativer Arbeitsansatz, aufgezeigt an der Arbeit mit tibetischen Migrantenkindern. (Tell the Children: A Beginning for Intercultural-Creative Work, Focusing on the Children of Tibetan Families.)

    ERIC Educational Resources Information Center

    Rabkin, Gabriele

    2001-01-01

    Explains the pedagogical and psychological concepts behind the approach developed by UNESCO that encourages children to express themselves freely on the subject of international understanding and peace in writing and art. Describes a project in which these concepts were applied focusing on a minority dispersed over many parts of the world:…

  8. "A talented young man" - The short life of Friedrich Wilhelm Tönnies, 1796-1817; (German Title: "Ein talentvoller junger Mann" - Das kurze Leben des Friedrich Wilhelm Tönnies, 1796-1817)

    NASA Astrophysics Data System (ADS)

    Schwemin, Friedhelm

    Friedrich Wilhelm Tönnies' name is hardly found in the major histories of astronomy. This is not surprising since he died before the age of twenty-one. Nevertheless, and perhaps because he knew at heart that not much time was granted to him, he left an astonishingly prolific oeuvre which indicates his rich talents. His contemporaries also testify that this son af a wealthy textile merchant had a great talent. But it is idle to speculate whether he would have become a second Bessel, or just an inconspicuous high school teacher in some remote Prussian province. He experienced a decisive career advancement by the Berlin astronomer J.E. Bode, obtained his Ph.D. already at the age of nineteen, published, among other things, about the large solar eclipse of November 19, 1816, and corresponded with several professional astronomers, before he succumbed to a pulmonary disease.

  9. [Distribution of financial resources according to the productivity (determined by bibliometry) in the Medical Research Laboratories of the Hospital das Clínicas da Faculdade de Medicina da Universidad de São Paulo (Brazil)].

    PubMed

    Montes, G S

    2000-04-01

    A challenge that research managers have to face is how to "reallocate" agency budgets in order to bring them in line with the results of performance reviews. Research policies must develop a strategic plan describing their goals, devise yardsticks to measure their progress, and tie that performance to allocate research funds with some degree of priority. Though Brazil already has a substantial presence in world's science, scientific enterprise must be used to strengthen it. The first step should be to raise standards in Brazilian science by concentrating the resources on supporting excellence. A strategy to judge biomedical research productivity should include tactics to disclose whether the resulting publications have appeared in the field's most respected, peer-reviewed journals. A pilot project to road-test the above-discussed ideas on performance measurements was conducted at the Laboratories of Medical Research (Clinical Hospital, University of São Paulo School of Medicine). These Laboratories perform a vast proportion of biomedical research at the country's largest University. This article illustrates that confidence in fairness and consistency with which funds are now being allocated has helped to improve productivity, thus showing that this strategy is fruitful.

  10. The Calendar Edict of 10 May 1700 by Friedrich III., Elector of Brandenburg (German Title: Das Kalender-Edikt des Brandenburgischen Kurfürsten Friedrich III. vom 10. Mai 1700)

    NASA Astrophysics Data System (ADS)

    Wielen, Roland

    The Calendar Edict of 10 May 1700 was issued by Friedrich III., Elector of Brandenburg. With this edict, he founded at Berlin an astronomical observatory and an academy of sciences. The Elector assigned to the academy the exclusive right to issue calendars in all his territories. Leibniz had proposed this in order to finance the academy and the observatory from the income of the calendar privilege. The astronomers were responsible for calculating and supervising the new calendar in Brandenburg and later in Prussia, which was introduced in 1700 in all the Protestant territories of Germany as the 'Improved Calendar'. We present here scans of the printed Calendar Edict and of the last page of the handwritten original with the signature of the Elector. Furthermore, we show images of a few pages of the calendar for 1701, the first one issued by the academy. Finally, we reproduce the full text of the Calendar Edict.

  11. James Baldwin und das Rassenproblem in den USA. Unterrichtsprojekt zum Komplex "Texte und ihre gesellschaftliche Bedingtheit" (James Baldwin and the Race Problem in the USA. Teaching Project in the Series "Texts and their Social Context")

    ERIC Educational Resources Information Center

    Kerschgens, Edda

    1977-01-01

    Reports on an 18-hour teaching project with students at a teachers' college. Four Baldwin texts were used. Questions considered included whether Baldwin's treatment of the race problem reveals any changes or shifts of emphasis. Suggestions are made for adaptation to teaching in grades 11-13. (Text is in German.) (IFS/WGA)

  12. [Not Available].

    PubMed

    Torres Díaz, Cristina V; Martín Peña, Gonzalo; Ezquiaga, Elena; Navas García, Marta; García de Sola, Rafael

    2016-07-19

    Gracias a los avances técnicos en técnicas neuroquirúrgicas, y debido a que el diagnóstico y la clasificación de las enfermedades psiquiátricas han evolucionado significativamente a lo largo de las últimas décadas, se están desarrollando tratamientos a nivel experimental para aquellos pacientes resistentes al manejo conservador.La anorexia nerviosa es una enfermedad de prevalencia creciente, con la tasa de mortalidad más elevada dentro de los trastornos psiquiátricos, y con aproximadamente un 20% de pacientes que presentan una evolución tórpida. Para estos pacientes que no responden a manejo conservador, la estimulación cerebral profunda ha surgido como una alternativa terapéutica, si bien la literatura especializada al respecto es escasa.A continuación presentamos una revisión de la fisiopatología de la anorexia nerviosa, así como de los distintos tratamientos neuroquirúrgicos realizados a lo largo de la historia. Se detalla la perspectiva de tratamiento quirúrgico actual, así como los aspectos éticos que se han de considerar en relación con el surgimiento de estas nuevas terapias.

  13. 50 CFR 648.92 - Effort-control program for monkfish limited access vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... reduced by the amount calculated in paragraph (b)(1)(v) of this section for the research DAS set-aside... § 648.95(g)(2). (v) Research DAS set-aside. A total of 500 DAS shall be set aside and made available for cooperative research programs as described in paragraph (c) of this section. These DAS shall be deducted from...

  14. Wie viel Kapazität hat ein Mobilfunknetz?

    NASA Astrophysics Data System (ADS)

    Eisenblätter, Andreas; Geerdes, Hans-Florian

    Wer hat das noch nicht erlebt? Der Akku ist aufgeladen und reichlich Guthaben vorhanden, doch das Telefonieren mit dem Handy klappt trotzdem nicht. Meist liegt das daran, dass man sich in einem Funkloch befindet. Aber manchmal ist auch das Netz überlastet. Anders gesagt: das Funknetz des Mobilfunkanbieters, das viele Antennen auf Hausdächern oder Masten umfasst, bietet entweder nicht genügend Abdeckung oder nicht genügend Kapazität. Genau das will der Anbieter natürlich vermeiden. Mathematik hilft, diese Herausforderungen mit einer guten Planung des Mobilfunknetzes zu bewältigen.

  15. Systems Engineering of Unmanned DoD Systems: Following the Joint Capabilities Integration and Development System/Defense Acquisition System Process to Develop an Unmanned Ground Vehicle System

    DTIC Science & Technology

    2015-12-01

    and Development System/Defense Acquisition System (JCIDS/DAS) process to gain insight into JCIDS/DAS as it relates to unmanned robotics systems...DAS regulations to tailor an SE approach in designing and building the TECHMAN robot , starting with the mission needs and requirements followed by...into the JCIDS/DAS process with regard to procurement of robotics systems. 14. SUBJECT TERMS JCIDS, DAS, unmanned systems, unmanned ground vehicle

  16. 50 CFR 648.262 - Effort-control program for red crab limited access vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... holders by letter of the newly calculated DAS allocation. (2) For fishing year 2010 and thereafter. Each... DAS (48 hours) for the fishing trip, even though the trip lasted only 23 hours. (4) Good...

  17. 77 FR 26548 - Issuance of an Experimental Use Permit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-04

    ... DAS59122-7 corn (Organization for Economic Co-operation and Development (OECD) Unique Identifier: DAS-59122... necessary for its production (Vestor PV-ZMCT01) in event MON 810 corn (OECD Unique Identifier: MON- 81 -6...

  18. Comparison of the Disease Activity Score using Erythrocyte Sedimentation Rate and C-reactive Protein in African-Americans with Rheumatoid Arthritis

    PubMed Central

    Tamhane, Ashutosh; Redden, David T.; McGwin, Gerald; Brown, Elizabeth E.; Westfall, Andrew O.; Reynolds, Richard J.; Hughes, Laura B.; Conn, Doyt L.; Callahan, Leigh F.; Jonas, Beth L.; Smith, Edwin A.; Brasington, Richard D.; Moreland, Larry W.; Bridges, S. Louis

    2014-01-01

    INTRODUCTION The Disease Activity Score based on 28 joints (DAS28) has been increasingly used in clinical practice and research studies of rheumatoid arthritis (RA). Studies have reported discordance between DAS28 based on erythrocyte sedimentation rate (ESR) versus C-reactive protein (CRP) in RA patients. However such comparison is lacking in African-Americans with RA. METHODS This analysis included participants from the Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis (CLEAR) Registry which enrolls self-declared African-Americans with RA. Using tender and swollen joint counts separate ESR-based and CRP-based DAS28 scores (DAS28-ESR3 and DAS28-CRP3) were calculated, as were DAS28-ESR4 and DAS28-CRP4, which included the patient’s assessment of disease activity. The scores were compared using paired t-test, simple agreement and kappa, correlation coefficient and Bland-Altman plots. RESULTS Of the 233 included participants, 85% were women, mean age at enrollment was 52.6 years, and median disease duration at enrollment was 21 months. Mean DAS28-ESR3 was significantly higher than DAS28-CRP3 (4.8 vs. 3.9; p<0.001). Similarly, mean DAS28-ESR4 was significantly higher than DAS28-CRP4 (4.7 vs. 3.9; p<0.001). ESR-based DAS28 remained higher than CRP-based DAS28 even when stratified by age, sex, and disease duration. Overall agreement was not high between DAS28-ESR3 and DAS28-CRP3 (50%) or between DAS28-ESR4 and DAS28-CRP4 (59%). DAS28-CRP3 underestimated disease activity in 47% of the participants relative to DAS28-ESR3 and DAS28-CRP4 in 40% of the participants relative to DAS28-ESR4. CONCLUSION There was significant discordance between the ESR-based and CRP-based DAS28 which could impact clinical treatment decisions in African-Americans with RA. PMID:23950187

  19. Single-Event Transgene Product Levels Predict Levels in Genetically Modified Breeding Stacks.

    PubMed

    Gampala, Satyalinga Srinivas; Fast, Brandon J; Richey, Kimberly A; Gao, Zhifang; Hill, Ryan; Wulfkuhle, Bryant; Shan, Guomin; Bradfisch, Greg A; Herman, Rod A

    2017-09-13

    The concentration of transgene products (proteins and double-stranded RNA) in genetically modified (GM) crop tissues is measured to support food, feed, and environmental risk assessments. Measurement of transgene product concentrations in breeding stacks of previously assessed and approved GM events is required by many regulatory authorities to evaluate unexpected transgene interactions that might affect expression. Research was conducted to determine how well concentrations of transgene products in single GM events predict levels in breeding stacks composed of these events. The concentrations of transgene products were compared between GM maize, soybean, and cotton breeding stacks (MON-87427 × MON-89034 × DAS-Ø15Ø7-1 × MON-87411 × DAS-59122-7 × DAS-40278-9 corn, DAS-81419-2 × DAS-44406-6 soybean, and DAS-21023-5 × DAS-24236-5 × SYN-IR102-7 × MON-88913-8 × DAS-81910-7 cotton) and their component single events (MON-87427, MON-89034, DAS-Ø15Ø7-1, MON-87411, DAS-59122-7, and DAS-40278-9 corn, DAS-81419-2, and DAS-44406-6 soybean, and DAS-21023-5, DAS-24236-5, SYN-IR102-7, MON-88913-8, and DAS-81910-7 cotton). Comparisons were made within a crop and transgene product across plant tissue types and were also made across transgene products in each breeding stack for grain/seed. Scatter plots were generated comparing expression in the stacks to their component events, and the percent of variability accounted for by the line of identity (y = x) was calculated (coefficient of identity, I(2)). Results support transgene concentrations in single events predicting similar concentrations in breeding stacks containing the single events. Therefore, food, feed, and environmental risk assessments based on concentrations of transgene products in single GM events are generally applicable to breeding stacks composed of these events.

  20. The απολογητοσ-riddle in Kepler's Astronomia Nova, chapter 57. (German Title: Das απολογητοσ-Rätsel in Keplers Astronomia Nova, Kapitel 57)

    NASA Astrophysics Data System (ADS)

    Kühn, Ernst

    Since 1937, the latin edition of Johannes Kepler's Astronomia Nova (1609) is available as a standard text. Here, in the 57th chapter, the third one of 48 important marginalia of Kepler, is reproduced as ⪉quo;Quae sit genuina et απολογητοσ mensura librationis huijus etc.». The Grecized word «αpi;ολογητοσ» was ignored to a large extent by translators and commentators, and was at least declared enigmatic by Donahue (1992). A look in the original copies of the 1609 edition shows that it is written ατιολογητοσ, not π but a τι. απολογητοσ in KGW is a read error. In the context of Keplers «natural, causal magnet-like forcesraquo; of planetary motion the conjecture αιτιολογητοσ (as a typographical error a ι is omitted) immediately suggests itself: causally, aetiological. This solution of the απολογητοσ riddle indicates the tight brace between the important Chapter 57 of Kepler's celestial physics and and the complete title ASTRONOMIA NOVA ΑΙΤΙΟΛΟΓΗΤΟΣ, SEV PHYSICA COELESTIS etc.

  1. Hilft es die Regel zu wissen um sie anzuwenden? Das Verhaltnis von Melatlinguistischem Bewusstsein und grammatischer Kompetenz (Is Knowledge of Grammar Rules Helpful in Their Application? The Relationship between Metalinguistic Insight and Grammar Competency in the Study of German as a Foreign Language).

    ERIC Educational Resources Information Center

    Schultz, Renate A.

    2002-01-01

    Examines to what extent, if at all, grammar instruction fosters or accelerates language acquisition. Presents a study investigating the acquisition of syntactic or morphological structures in 340 students learning German as a foreign language. The results are discussed. (AS)

  2. Disciplines and Professors of Astronomy in Undergraduate Physics Teachers Formation Courses in Brazilian Universities. (Spanish Title: Disciplinas y Profesores de Astronomia en los Cursos de Licenciatura en Física en Las Universidades Brasileñas.) Disciplinas e Professores de Astronomia Nos Cursos de Licenciatura em Física das Universidades Brasileiras

    NASA Astrophysics Data System (ADS)

    Roberto, Artur Justiniano, Jr.; Reis, Thiago Henrique; dos Reis Germinaro, Daniel

    2014-12-01

    This article is the result of a research on basic training in Astronomy in physics degrees that performed the ENADE 2011 national examination. The objective was to identify whether there are disciplines of Astronomy in these courses, whether are mandatory or optional, its workload and when it is offered. The relationship between astronomers, physics degrees and disciplines of Astronomy was investigated. To perform this research we examined the results of ENADE 2011 and also the census of Brazilian Astronomical Society. As a result it is observed that in only 15% of the courses there is a mandatory subject of Astronomy, and therefore there is a high probability that 85% of physics teachers trained in 2011 have not had any discipline of Astronomy during their graduation. In addition, the data collected in this study shows a low number of members of SAB (Sociedade Astronômica Brasileira) among the surveyed courses. We have verified that the presence of astronomers in a given university does not imply to have a mandatory discipline of Astronomy in physics degrees at the same university. Este artículo es el resultado de una investigación sobre la formación básica en Astronomía en los cursos de Profesorado en Física que hicieron el examen nacional ENADE 2011. El objetivo del trabajo fue identificar se existen disciplinas de Astronomía en estos cursos, si son obligatorias u optativas, cuál es su carga horaria y el semestre en que son ofrecidas. Se investigó también la correlación entre astrónomos, los cursos de licenciatura en Física y las disciplinas de Astronomía. Para realizar esta investigación se utilizaron los datos del ENADE 2011 y también del censo de la Astronomía brasileña. Como resultado, se observó que en solo 15% de los cursos existe una disciplina obligatoria de Astronomía y que existe una grande probabilidad de que 85% de los profesores de Física formados en el año de 2011 no hayan cursado ninguna disciplina de Astronomía durante su formación. Aparte de eso, los datos levantados en este trabajo apuntan para un número bajo de afiliados a la SAB (Sociedade Astronômica Brasileira) en los cursos investigados. Se verificó que tener astrónomos en una institución no implica tener una disciplina obligatoria de Astronomía en el curso de licenciatura en Física. Este artigo é o resultado de uma pesquisa sobre a formação básica em Astronomia nos cursos de Licenciatura em Física que fizeram o exame nacional ENADE 2011. O objetivo do trabalho foi identificar se há disciplinas de Astronomia nesses cursos, se ela é obrigatória ou optativa/eletiva, qual a sua carga horária e o período em que é oferecida. Pesquisou-se também a relação entre astrônomos, cursos de Licenciatura em Física e disciplinas de Astronomia. Para realizar essa pesquisa utilizamos os dados do ENADE 2011 e também do censo da Astronomia brasileira. Como resultado, se observa que em apenas 15% dos cursos existe uma disciplina obrigatória de Astronomia e que há uma grande probabilidade de que 85% dos professores de Física formados em 2011 não cursaram nenhuma disciplina de Astronomia durante a graduação. Além disso, os dados levantados nesse trabalho apontam um baixo número de filiados à SAB nos cursos pesquisados. Identifica-se que ter astrônomos na instituição não implica em disciplina obrigatória de Astronomia no curso de Licenciatura em Física.

  3. Astronomical discoveries and the renown of a late humanistic scholar - Marx Welser's role in the discussion on sunspots between Scheiner, Galilei and Kepler. (German Title: Astronomische Entdeckungen und das Renommee eies späthumanistischen Gelehrten - Marx Welsers Rolle in der Sonnenfleckendiskussion zwischen Scheiner, Galilei und Kepler)

    NASA Astrophysics Data System (ADS)

    Ferber, Magnus Ulrich

    The example of the late humanistic scholar Max Welser (1558-1614) from Augsburg proves the gain of recognition of astronomy in the scholarly surroundings, which arose through its new results after the invention of the telescope. This explains why an exponent of the humanistic ideal of education worked towards appearing as the patron of a professional astronomical debate, as it was done by Welser, in 1611-1613, in the debate on sunspots between Christoph Scheiner and Galileo Galilei. Nevertheless, the split in the scholarly world between humanists and scientists proved to be so fundamental at that time, that Welser, in order to be accepted also by the mathematici, had to establish anew his renown in these circles independent of his philological achievements. At the same time, he did not undertake anything to integrate the astronomers into the humanistic res publica litteraria.

  4. Experiment ueber den Einflusse von Metaboliten und Antimetaboliten am Modell von Trichomonas Vaginalis. IV. Mitteilung: Vitamine, die das Wachstum von Trichomonas Vaginalis Beguenstigen (Experiments on the Influence of Metabolites and Antimetabolites on the Model of Trichomonas Vaginalis. IV. Communication: Vitamins Favouring the Growth of Trichomonas Vaginalis),

    DTIC Science & Technology

    A number of vitamins have been investigated for their influence upon Trichomonas vaginalis . At a concentration of 0.20 mg ml vitamin A has...stimulating action upon the growth of Trichomonas vaginalis . Vitamin D2 has been shown to favour Trichomonas multiplication in all experimental series...Vitamin D3 generally favours the Trichomonas vaginalis population. Addition of vitamin E resulted in enhanced multiplication of Trichomonas and longer

  5. Patrik and Putrik and Clown Ferdl; Findings and Cognition on the Television Perception of Children and Young People Based on the Prize-Winning Programmes of Prix Jeunesse 1966. Publications of the Internationales Zentralinstitut fur das Jugend- und Bildungsfernsehen, Number 3.

    ERIC Educational Resources Information Center

    Griebel, Francine, Ed.; Burger, Anette, Ed.

    The results of an investigation of the reactions of young children (ranging from four to nine years of age) in France, Germany, England, America, and Czechoslovkia to two Prix Jeunesse winning television films are examined in this document. Summarized reports from each of the participating countries for the film "Patrik and Putrik" and,…

  6. The void comprises everything - natural philosophy and science in Otto von Guericke's proof of existence of empty and infinite space. (German Title: Alles umfasst es, das Nichts - Naturphilosophie und Naturwissenschaft im Existenzbeweis des leeren und unendlichen Weltraums bei Otto von Guericke)

    NASA Astrophysics Data System (ADS)

    Gabriel, Peter

    Otto von Guericke showed in his book Experimenta nova (ut vocantur) Magdeburgica de vacuo spatio that space is an infinite void. This contribution illustrates how Guericke mixed natural philosophy and natural science in his argumentation with each other.

  7. Characterizations of F-superconductors and selected F-compounds, amorphous carbon, and (VO)2P2O7 by F-19, C-13, H-1, and P-31 NMR, and a new probe for multiple pulse, MAS, and DAS NMR

    NASA Astrophysics Data System (ADS)

    Pan, Hongjun

    1991-04-01

    NMR signals of F-19 were measured in the polycrystalline inorganic conductor Ag2F and in the polycrystalline insulators AgF, YOF, EuOF, YF3, CuF2, BaF2, and KF to compare them to the signals found in the so-called 1-2-3-type compounds with claimed formulas RBa2Cu3O(7-x)F(x) (R = Y and Eu). No evidence for a Knight-shifted, built-in fluorine-signal was found in the 1-2-3-type superconductors. The only signal found was from the BaF2 which is an impurity in the superconductors.

  8. A Reexamination of the Dimensionality of Death Anxiety.

    ERIC Educational Resources Information Center

    Levin, Richard

    1990-01-01

    Administered Death Anxiety Scale (DAS) and Minnesota Multiphasic Personality Inventory (MMPI) to 105 individuals. Factor analysis of DAS revealed general factor accounting for 29 percent of extracted variance. First-order factors were also important in factor solution. Pattern of MMPI-DAS correlation suggests that confounding of factors greatly…

  9. 76 FR 23940 - Fisheries of the Northeastern United States; Atlantic Sea Scallop Fishery; Framework Adjustment 22

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-29

    ... biomass projections. The proposed FY 2013 DAS allocations would be set at a precautionary level (i.e., 75 percent of what current biomass levels project would be the DAS allocation for the entire FY). In addition... Table 2. FY 2013 DAS allocations are precautionary, and are set at 75 percent of what current biomass...

  10. “&ldots;how the right technique emerged at the right time” Zur Geschichte der fotografischen Methode im Kalten Krieg

    NASA Astrophysics Data System (ADS)

    Fengler, Silke

    Die Frühgeschichte der fotografischen Methode, die als Nachweisinstrument kernphysikalischer und kosmischer Strahlung in den 1950er Jahren zur Blüte kam, hat das Interesse vieler Wissenschaftshistoriker gefunden. Peter Galison hat gezeigt, wie fragil das Experimentalsystem lange Zeit war, das sich um die Methode bildete, und wie prekär die mit ihr aufgezeichneten Ergebnisse.

  11. Distributed Acoustic Sensing for Imaging Near-Surface Geology and Monitoring Traffic at Garner Valley, California

    NASA Astrophysics Data System (ADS)

    Lancelle, Chelsea

    Distributed Acoustic Sensing (DAS) is a relatively new technology that uses a fiber-optic cable as a sensor. DAS got its start in the energy industry for borehole monitoring and more recently has started being used in horizontal arrays. The DAS technique senses strain rates every 1 m over distances of up to 100 km of cable length with sampling rates as fast as 100 kHz. This dissertation uses a horizontal DAS array in Southern California to evaluate the use of DAS for imaging near-surface geology and monitoring traffic. The first chapter uses Multichannel Analysis of Surface Waves to evaluate the response of DAS to surface waves. Dispersion curves from the DAS array match well with results from 1) other instruments at the site, 2) ambient noise correlation functions using the same DAS array, and 3) previous studies at the site. The second chapter uses the DAS array to create 2D tomographic images of the site for a number of pixel sizes and the directional sensitivity of DAS is discussed. The third chapter explores the possibility of using DAS for traffic monitoring. Vehicle counts, relative amplitudes, and velocities are identified and prove DAS could be used for traffic monitoring.

  12. Development and Validation of the Dysfunctional Attitude Scale: A Preliminary Investigation.

    ERIC Educational Resources Information Center

    Weissman, Arlene N.; Beck, Aaron T.

    The Dysfunctional Attitude Scale (DAS) was developed to measure pervasive negative attitudes of a depressed person towards self, outside world, and future. The DAS follows Beck's construct of cognitive dysfunction. Two studies investigated the psychometric properties of the DAS and the relationship between cognition and affect in 300 normal…

  13. Efficiently Assessing Negative Cognition in Depression: An Item Response Theory Analysis of the Dysfunctional Attitude Scale

    ERIC Educational Resources Information Center

    Beevers, Christopher G.; Strong, David R.; Meyer, Bjorn; Pilkonis, Paul A.; Miller, Ivan R.

    2007-01-01

    Despite a central role for dysfunctional attitudes in cognitive theories of depression and the widespread use of the Dysfunctional Attitude Scale, form A (DAS-A; A. Weissman, 1979), the psychometric development of the DAS-A has been relatively limited. The authors used nonparametric item response theory methods to examine the DAS-A items and…

  14. Efficiently Assessing Negative Cognition in Depression: An Item Response Theory Analysis of the Dysfunctional Attitude Scale

    ERIC Educational Resources Information Center

    Beevers, Christopher G.; Strong, David R.; Meyer, Bjorn; Pilkonis, Paul A.; Miller, Ivan R.

    2007-01-01

    Despite a central role for dysfunctional attitudes in cognitive theories of depression and the widespread use of the Dysfunctional Attitude Scale, form A (DAS-A; A. Weissman, 1979), the psychometric development of the DAS-A has been relatively limited. The authors used nonparametric item response theory methods to examine the DAS-A items and…

  15. 50 CFR 648.86 - NE Multispecies possession restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... NE multispecies DAS, a limited access Handgear A permit, an open access Handgear B permit, or a... under a NE multispecies DAS, a limited access Handgear A permit, an open access Handgear B permit, or a... DAS, a limited access Handgear A permit, an open access Handgear B permit, or a monkfish limited...

  16. 75 FR 3234 - Issuance of an Experimental Use Permit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... [Organization for Economic Cooperation and Development (OECD) Unique Identifier: DAS-01507-1] 2. Bacillus... production in corn event DAS-59122-7 (OECD Unique Identifier: DAS-59122-7) 3. Bacillus thuringiensis Cry1Ab... event Bt11 (OECD Unique Identifier: SYN-BT011-1) 4. Bacillus thuringiensis Cry1Ab delta-endotoxin...

  17. 76 FR 4683 - Pesticide Experimental Use Permit; Receipt of Application; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-26

    ... DAS59122-7 corn (Organisation for Economic Co-operation and Development (OECD) Unique Identifier: DAS-59122... its production (Vestor PV-ZMCT01) in event MON 810 corn (OECD Unique Identifier: MON- 81 -6). The... material necessary for their production (PHP17662 T-DNA) in event DAS59122-7 corn (OECD Unique Identifier...

  18. Elektrotechnik

    NASA Astrophysics Data System (ADS)

    Böge, Gert

    Ursprünglicher Sitz der Elektrizität ist das Atom. Das Wasserstoffatom z.B. besteht aus einem Proton als Kern und einem Elektron, das diesen Kern auf einer bestimmten Bahn umkreist. Das Proton bezeichnet man als elektrisch positiv, - das Elektron als negativ geladen. Zwischen beiden befindet sich die "Elektrizität“ in Form eines besonderen Raumzustandes, der als elektrisches Feld bezeichnet wird. Normalerweise erscheint ein Stoff nach außen hin elektrisch neutral, weil ebenso viele positive wie negative Ladungen in ihm enthalten sind.

  19. The garlic ingredient diallyl sulfide induces Ca(2+) mobilization in Madin-Darby canine kidney cells.

    PubMed

    Chen, Ching-Hsein; Su, Shu-Jem; Chang, Kee-Lung; Huang, Mei-Wen; Kuo, Soong-Yu

    2009-09-01

    Diallyl sulfide (DAS), one of the major organosulfur compounds (OSCs) of garlic, is recognized as a group of potential chemoproventive compounds. In this study, we examines the early signaling effects of DAS on renal cells loaded with Ca(2+)-sensitive dye fura-2. It was found that DAS caused an immediate and sustained rise of [Ca(2+)](i) in a concentration-dependent manner (EC(50)=2.32 mM). DAS also induced a [Ca(2+)](i) elevation when extracellular Ca(2+) was removed, but the magnitude was reduced by 45%. Depletion of intracellular Ca(2+) stores with CCCP, a mitochondrial uncoupler, did not affect DAS's effect. In Ca(2+)-free medium, the DAS-induced [Ca(2+)](i) rise was abolished by depleting stored Ca(2+) with thapsigargin (an endoplasmic reticulum Ca(2+) pump inhibitor). DAS-caused [Ca(2+)](i) rise in Ca(2+)-containing medium was not affected by modulation of protein kinase C activity. The DAS-induced Ca(2+) influx was blocked by nicardipine. U73122, an inhibitor of phospholipase C, abolished ATP (but not DAS)-induced [Ca(2+)](i) rise. Additionally, pretreatment with DAS for 24 h decreased cell viability in a concentration-dependent manner. Furthermore, DAS-induced cell death involved apoptotic events. These findings suggest that diallyl sulfide induced a significant rise in [Ca(2+)](i) in MDCK renal tubular cells by stimulating both extracellular Ca(2+) influx and thapsigargin-sensitive intracellular Ca(2+) release via as yet unidentified mechanisms.

  20. Dasatinib-loaded albumin nanoparticles possess diminished endothelial cell barrier disruption and retain potent anti-leukemia cell activity

    PubMed Central

    Li, Zhenyu; Shetty, Sreerama; Fu, Jian

    2016-01-01

    Dasatinib (DAS), a second-generation tyrosine kinase inhibitor, is highly effective in treating chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. However, its clinical use is limited due to serious adverse effects. DAS can disrupt endothelial barrier integrity and increase endothelial permeability which may cause peripheral edema and pleural effusion. Albumin nanoparticles (NPs) as a drug carrier may serve as a useful tool for cell-selective drug delivery to reduce DAS-induced endothelial hyperpermeability and maintain endothelial barrier integrity. In this study, we reported that DAS-loaded NPs exhibited potent anti-leukemia efficacy as DAS alone. Importantly, albumin NPs as a drug carrier markedly reduced DAS-induced endothelial hyperpermeability by restraining the inhibition of Lyn kinase signaling pathway in endothelial cells. Therefore, albumin NPs could be a potential tool to improve anti-leukemia efficacy of DAS through its cell-selective effects. PMID:27391073

  1. Diallyl sulfide induces the expression of nucleotide excision repair enzymes in the breast of female ACI rats.

    PubMed

    Green, Mario; Newell, Oneil; Aboyade-Cole, Ayoola; Darling-Reed, Selina; Thomas, Ronald D

    2007-01-10

    Diethylstilbestrol (DES) causes DNA adducts resulting in breast cancer, whereas diallyl sulfide (DAS) inhibits cancer formation. We hypothesize that DAS induces the expression of nucleotide excision repair genes. To test this hypothesis, female ACI rats were treated for 4 days with corn oil, DES, DAS, and DAS/DES (50mg/kg). The expression of P53, Gadd45a, PCNA, and DNA polymerase delta was analyzed by real-time PCR. DES decreased the expression of P53, Gadd45a and PCNA. DAS and DAS/DES increased the expression of all four genes. These results suggest that DAS enhances the ability of breast tissue to repair DNA damage thus preventing cancer.

  2. Detailed Analysis of the Articular Domain in Patients with Primary Sjögren Syndrome.

    PubMed

    Moerman, Rada V; Arends, Suzanne; Meiners, Petra M; Vissink, Arjan; Spijkervet, Frederik K L; Kroese, Frans G M; Brouwer, Elisabeth; Bootsma, Hendrika

    2017-03-01

    We used the 28-joint Disease Activity Score (DAS28) and the European League Against Rheumatism Sjögren's Syndrome Disease Activity Index (ESSDAI) articular domain to assess the effect of rituximab (RTX) and abatacept (ABA) on articular involvement in primary Sjögren syndrome (pSS). Patients with pSS treated with RTX (n = 18) or ABA (n = 13) and having a DAS28 erythrocyte sedimentation rate (ESR)/C-reactive protein (CRP) level ≥ 3.2 at baseline were selected. Generalized estimating equations were used to analyze the DAS28 and ESSDAI articular domain over time. In the RTX group, DAS28-ESR/CRP decreased significantly up to 48 weeks. In the ABA group, DAS28-ESR/CRP decreased significantly up to 24 weeks. DAS28 correlated significantly with ESSDAI articular domain. DAS28 is useful to evaluate the effect of biologicals on articular involvement in patients with pSS.

  3. Diallyl sulfide induces the expression of estrogen metabolizing genes in the presence and/or absence of diethylstilbestrol in the breast of female ACI rats.

    PubMed

    Green, Mario; Newell, Oneil; Aboyade-Cole, Ayoola; Darling-Reed, Selina; Thomas, Ronald D

    2007-01-10

    Diethylstilbestrol (DES) induces mammary tumors in female ACI rats and is associated with an increased risk of developing breast cancer in humans. Diallyl sulfide (DAS) has been shown to prevent cancer in animals. Previously, we have shown that DAS inhibits the production of DES induced DNA adducts when given prior to DES. We hypothesize that DAS alters the expression of genes responsible for DES metabolism. To test this hypothesis, four groups of 10 female ACI rats were treated daily for four days as follows: (1) corn oil, (2) 50mg/kg DES, (3) 50mg/kg DAS, and (4) 50mg/kg DAS+50mg/kg DES. RNA was isolated from breast tissue and mRNA levels of CYP1A1, CYP1B1, glutathione-S-transferase (GST) and superoxide dismutase (SOD) were analyzed by real-time PCR. DES, DAS, and DES/DAS treatments increased the expression of CYP1A1 by 2.1-, 4.7-, and 12.7-fold, respectively. Similar results were seen for CYP1B1. DES decreased the expression of GST by 23%, whereas DAS and DAS/DES treatments increased the expression of GST by 12- and 16.7-fold, respectively. Similar results were seen with SOD. These results suggests that DAS may prevent the formation of DES induced DNA damage by altering the expression of DES metabolizing genes.

  4. Protective effects of diallyl sulfide on acetaminophen-induced toxicities.

    PubMed

    Hu, J J; Yoo, J S; Lin, M; Wang, E J; Yang, C S

    1996-10-01

    Diallyl sulfide (DAS), a major flavour component of garlic, is known to modulate drug metabolism and may protect animals from chemically induced toxicity and carcinogenesis. In this study the effects of DAS on the oxidative metabolism and hepatotoxicity induced by acetaminophen (APAP) in rats were investigated. In the hepatotoxicity evaluation of Fischer 344 rats there was a dose-dependent increase in the odds of mortality rate by APAP (P = 0.009); DAS treatment significantly protected rats from APAP-related mortality (P = 0.026). Liver toxicity determined by lactate dehydrogenase activity was significantly increased by APAP treatment (0.75 g/kg). Pretreatment with DAS protected animals from APAP-induced liver toxicity in a time- and dose-dependent fashion. Treatment of DAS (50 mg/kg) 3 hr after APAP dosing significantly (P < 0.05) protected rats from APAP-induced liver toxicity. The metabolism of APAP (50 microM) in vitro was significantly inhibited by DAS (0.3-1 mM) in liver microsomes isolated from F344 rats. As the effect of DAS on APAP-induced hepatotoxicity in vivo was observed only when DAS was administered before or shortly after (< 3 hr) APAP dosing, data suggested that the protective effect of DAS is mainly at the metabolic activation step of APAP. However, the possibility that DAS may also have effects on other drug metabolism systems, such as glutathione (GSH) and glutathione S-transferases, cannot be ruled out.

  5. Transcriptional activation of the herpes simplex virus type 1 UL38 promoter conferred by the cis-acting downstream activation sequence is mediated by a cellular transcription factor.

    PubMed

    Guzowski, J F; Singh, J; Wagner, E K

    1994-12-01

    The herpes simplex virus (HSV) type 1 strict late (gamma) UL38 promoter contains three cis-acting transcriptional elements: a TATA box, a specific initiator element, and the downstream activation sequence (DAS). DAS is located between positions +20 and +33 within the 5' untranslated leader region and strongly influences transcript levels during productive infection. In this communication, we further characterize DAS and investigate its mechanism of action. DAS function has a strict spacing requirement, and DAS contains an essential 6-bp core element. A similarly positioned element from the gamma gC gene (UL44) has partial DAS function within the UL38 promoter context, and the promoter controlling expression of the gamma US11 transcript contains an identically located element with functional and sequence similarity to UL38 DAS. These data suggest that downstream elements are a common feature of many HSV gamma promoters. Results with recombinant viruses containing modifications of the TATA box or initiator element of the UL38 promoter suggest that DAS functions to increase transcription initiation and not the efficiency of transcription elongation. In vitro transcription assays using uninfected HeLa nuclear extracts show that, as in productive infection with recombinant viruses, the deletion of DAS from the UL38 promoter dramatically decreases RNA expression. Finally, electrophoretic mobility shift assays and UV cross-linking experiments show that DAS DNA forms a specific, stable complex with a cellular protein (the DAS-binding factor) of approximately 35 kDa. These data strongly suggest that the interaction of cellular DAS-binding factor with DAS is required for efficient expression of UL38 and other HSV late genes.

  6. Factors Associated With Coronary Artery Disease Progression Assessed By Serial Coronary Computed Tomography Angiography.

    PubMed

    Camargo, Gabriel Cordeiro; Rothstein, Tamara; Derenne, Maria Eduarda; Sabioni, Leticia; Lima, João A C; Lima, Ronaldo de Souza Leão; Gottlieb, Ilan

    2017-05-01

    ções por ACTC entre dezembro de 2005 e março de 2013. Devido às limitações na quantificação da progressão da DAC, os pacientes que haviam sido submetidos previamente à revascularização cirúrgica ou intervenção coronariana percutânea (ICP) entre as avaliações foram excluídos. A progressão da DAC foi definida como qualquer aumento no escore adaptado de estenose segmentar (calculado com utilização do número de segmentos afetados e gravidade da estenose) em todos os segmentos coronarianos sem stent (restenose intra-stent foi excluída da análise). Regressão logística stepwise foi utilizada para avaliar as variáveis associadas com a progressão da DAC. De uma população final de 234 pacientes, um total de 117 (50%) pacientes apresentaram progressão da DAC. Em um modelo considerando os principais fatores de risco para DAC e outras características basais, apenas a idade (odds ratio [OR] 1,04, intervalo de confiança de 95% [IC95%] 1,01-1,07), intervalo entre avaliações (OR 1,03, IC95% 1,01-1,04) e ICP prévia (OR 3,66, IC95% 1,77-7,55) mostraram uma relação independente com a progressão da DAC. Uma história de ICP com implante de stent esteve independentemente associada a um aumento de 3,7 vezes na chance de progressão da DAC, excluindo a restenose intra-stent. Idade e intervalo entre avaliações também foram preditores independentes de progressão.

  7. Laryngeal complications by orotracheal intubation: Literature review.

    PubMed

    Mota, Luiz Alberto Alves; de Cavalho, Glauber Barbosa; Brito, Valeska Almeida

    2012-04-01

    Introdução: As lesões causadas pela intubação orotraqueal são comuns no nosso meio e amplamente relatadas pela literatura. Geralmente são causadas por acidentes na colocação do tubo ou consequência de sua permanência nas vias aéreas do paciente. Há diversos tipos de lesões laríngeas, causadas por múltiplos mecanismos.Objetivo: Verificar, na literatura, as principais causas de complicações laríngeas pós-intubação orotraqueal e seus mecanismos de lesão.Revisão de Literatura: As bases de dados pesquisadas foram LILACS, BIREME e SCIELO. Foram utilizados artigos, livros e teses, delimitando-se o período entre 1953 a 2009. As palavras-chaves utilizadas para a busca dos artigos foram: complicações, lesões, laringe, intubação, entubação, endotraqueal, orotraqueal, granulomas, estenose. Foram selecionadas 59 referências. Os critérios de inclusão utilizados para a escolha dos artigos foram os que mostraram os diversos tipos de lesões ocasionadas pela intubação orotraqueal e suas fisiopatologias.Considerações Finais: Esta revisão de literatura foi motivada pela observação na prática clínica de um grande número de sequelas laríngeas em pacientes submetidos à intubação orotraqueal. Diante disto é importante o conhecimento, pelos profissionais da área de saúde, dos tipos de complicações e de suas causas, com o intuito de evitá-las, adotando medidas de prevenção dessas lesões.

  8. Modellierung und Simulation des Substrat-Rauschens in integrierten RF CMOS-Schaltungen

    NASA Astrophysics Data System (ADS)

    Lin, L.; Xiong, J.; Mathis, W.

    2009-05-01

    Im integrierten CMOS-Schaltungsentwurf kann das Substrat-Rauschen, das vom digitalen Teil entsteht, die Funktionalität des analogen Teils stark beeinflussen. Es wird daher immer wichtiger, das Substrat als ein Medium der Rauschen-Propagation genau zu modellieren. Im vorliegenden Artikel wird ein auf der Finite Elemente Methode (FEM) und Modellordnungsreduktion (MOR) basiertes Modellierungsverfahren zur Admittanzen-Extraktion im Halbleitersubstrat vorgestellt. Nach der Diskretisierung mit FEM wird das Substrat im Allgemeinen als ein resistives/kapazitives Netz angesehen. Durch Bestimmung der Admittanz-Matrix und MOR ist es möglich ein äquivalentes Dreipol-Modell zwischen digitalem und analogem Teil über das Substrat zu bilden. Das Ergebnis der Modellierung wird dargestellt und mit numerischer Simulation des Substrat-Rauschens verglichen. Die Modellierung ermöglicht es, die Einflüsse des Substrat-Rauschens im Schaltungsentwurf zu berücksichtigen und so bestehende CMOS-Schaltungsarchitekturen zu optimieren.

  9. A double antibody sandwich enzyme-linked immunosorbent assay for detection of soft-shelled turtle iridovirus antigens.

    PubMed

    Zhang, M; Yang, J X; Lin, X M; Zhu, C H; He, J Q; Liu, H; Lin, T L

    2010-08-01

    A double antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA) for detection of the soft-shelled turtle iridovirus (STIV) was developed using a specific monoclonal antibody (mAb) against STIV and anti-STIV rabbit serum. Using DAS-ELISA, the detection limit of STIV was found to be 10(3)PFU/ml. The positive rate of 15 STIV samples was 100%, while the positive rate of 100 other aquatic virus samples was 0%. These data show that DAS-ELISA is highly specific and sensitive for the detection of STIV. In clinical tests, 128 samples isolated from pond-reared turtles were subjected to DAS-ELISA and PCR. The overall agreement between the results obtained by DAS-ELISA and PCR was 98.4%. The results indicate that the DAS-ELISA method could be used for diagnosing diseases caused by STIV. Copyright (c) 2010 Elsevier B.V. All rights reserved.

  10. Formation of nanometal particles in the dialdehyde starch matrix.

    PubMed

    Khachatryan, Karen; Khachatryan, Gohar; Fiedorowicz, Maciej; Para, Andrzej; Tomasik, Piotr

    2013-10-15

    Environmentally friendly method of the preparation of dialdehyde starch (DAS) based composites containing nanosilver (DAS/Ag) and nanogold (DAS/Au) as reducing and protecting agents was developed. UV-vis spectroscopy, transmission electron microscopy (TEM) and X-ray diffraction (XRD) confirmed formation of about 10nm ball shaped Ag and Au nanoparticles situated within the polysaccharide template. Thermal properties of the composites were characterized involving differential scanning calorimetry (DSC), whereas molecular weights of polysaccharide chains of the matrix were estimated with the size exclusion chromatography coupled with multiangle laser light scattering and refractometric detectors (HPSEC-MALLS-RI). Formation of nanosilver and nanogold containing composites led to induction of the polymerization and/or crosslinking reactions of DAS molecules, resulting in a significant rise of molecular weight of polysaccharide chains constituting DAS/Ag and DAS/Au composite templates. Copyright © 2013 Elsevier Ltd. All rights reserved.

  11. Data acquisition system time measurement capabilities using WorkBench[trademark] software

    SciTech Connect

    Coutts, D.A.

    1992-04-01

    There is an increasing interest in the ability to measure transient behavior in the Heat Transfer Laboratory (HTL). To accomplish this the timing system behavior for the Data Acquisition Systems (DAS) must be evaluated. This report discusses the evaluation of a DAS timing system using WorkBench[trademark] Software in a Macintosh II environment. It also describes a method which can be successfully used to calibrate the timing system associated with the DAS.

  12. Data acquisition system time measurement capabilities using WorkBench{trademark} software

    SciTech Connect

    Coutts, D.A.

    1992-04-01

    There is an increasing interest in the ability to measure transient behavior in the Heat Transfer Laboratory (HTL). To accomplish this the timing system behavior for the Data Acquisition Systems (DAS) must be evaluated. This report discusses the evaluation of a DAS timing system using WorkBench{trademark} Software in a Macintosh II environment. It also describes a method which can be successfully used to calibrate the timing system associated with the DAS.

  13. What information is used in treatment decision aids? A systematic review of the types of evidence populating health decision aids.

    PubMed

    Clifford, Amanda M; Ryan, Jean; Walsh, Cathal; McCurtin, Arlene

    2017-02-23

    Patient decision aids (DAs) are support tools designed to provide patients with relevant information to help them make informed decisions about their healthcare. While DAs can be effective in improving patient knowledge and decision quality, it is unknown what types of information and evidence are used to populate such decision tools. Systematic methods were used to identify and appraise the relevant literature and patient DAs published between 2006 and 2015. Six databases (Academic Search Complete, AMED, CINAHL, Biomedical Reference Collection, General Sciences and MEDLINE) and reference list searching were used. Articles evaluating the effectiveness of the DAs were appraised using the Cochrane Risk of Bias tool. The content, quality and sources of evidence in the decision aids were evaluated using the IPDASi-SF and a novel classification system. Findings were synthesised and a narrative analysis was performed on the results. Thirteen studies representing ten DAs met the inclusion criteria. The IPDASI-SF score ranged from 9 to 16 indicating many of the studies met the majority of quality criteria. Sources of evidence were described but reports were sometimes generic or missing important information. The majority of DAs incorporated high quality research evidence including systematic reviews and meta-analyses. Patient and practice evidence was less commonly employed, with only a third of included DAs using these to populate decision aid content. The quality of practice and patient evidence ranged from high to low. Contextual factors were addressed across all DAs to varying degrees and covered a range of factors. This is an initial study examining the information and evidence used to populate DAs. While research evidence and contextual factors are well represented in included DAs, consideration should be given to incorporating high quality information representing all four pillars of evidence based practice when developing DAs. Further, patient and expert practice

  14. In vitro efficacy of diallyl sulfides against the periodontopathogen Aggregatibacter actinomycetemcomitans.

    PubMed

    Velliyagounder, Kabilan; Ganeshnarayan, Krishnaraj; Velusamy, Senthil Kumar; Fine, Daniel H

    2012-05-01

    The in vitro antibacterial effects of diallyl sulfide (DAS) against the Gram-negative periodontopathogen Aggregatibacter actinomycetemcomitans, the key etiologic agent of the severe form of localized aggressive periodontitis and other nonoral infections, were studied. A. actinomycetemcomitans was treated with garlic extract, allicin, or DAS, and the anti-A. actinomycetemcomitans effects of the treatment were evaluated. Garlic extract, allicin, and DAS significantly inhibited the growth of A. actinomycetemcomitans (greater than 3 log; P < 0.01) compared to control cells. Heat inactivation of the garlic extracts significantly reduced the protein concentration; however, the antimicrobial effect was retained. Purified proteins from garlic extract did not exhibit antimicrobial activity. Allicin lost all its antimicrobial effect when it was subjected to heat treatment, whereas DAS demonstrated an antimicrobial effect similar to that of the garlic extract, suggesting that the antimicrobial activity of garlic extract is mainly due to DAS. An A. actinomycetemcomitans biofilm-killing assay performed with DAS showed a significant reduction in biofilm cell numbers, as evidenced by both confocal microscopy and culture. Scanning electron microscopy (SEM) analysis of DAS-treated A. actinomycetemcomitans biofilms showed alterations of colony architecture indicating severe stress. Flow cytometry analysis of OBA9 cells did not demonstrate apoptosis or cell cycle arrest at therapeutic concentrations of DAS (0.01 and 0.1 μg/ml). DAS-treated A. actinomycetemcomitans cells demonstrated complete inhibition of glutathione (GSH) S-transferase (GST) activity. However, OBA9 cells, when exposed to DAS at similar concentrations, showed no significant differences in GST activity, suggesting that DAS-induced GST inhibition might be involved in A. actinomycetemcomitans cell death. These findings demonstrate that DAS exhibits significant antibacterial activity against A. actinomycetemcomitans and

  15. Finanzierung des Studiums

    NASA Astrophysics Data System (ADS)

    Domnick, Ivonne

    "Das liebe Geld“ - ein Thema, das Sie durch das ganze Studium begleitet und auch in der Examensphase und bei der späteren Berufswahl eine entscheidende Rolle spielen wird. Naturwissenschaftler und Ingenieure haben auf dem Arbeitsmarkt sicher derzeit die Nase vorn und brauchen sich über ihre berufliche Zukunft nicht so große Gedanken machen. Doch vor der Karriere muss zunächst einmal eine sichere Studienfinanzierung auf die Beine gestellt werden.

  16. No further gain can be achieved by calculating Disease Activity Score in 28 joints with high-sensitivity assay of C-reactive protein because of high intraindividual variability of C-reactive protein: A cross-sectional study and theoretical consideration.

    PubMed

    Hansen, Inger M J; Emamifar, Amir; Andreasen, Rikke A; Antonsen, Steen

    2017-01-01

    Disease Activity Score in 28 joints (DAS28) is commonly used to evaluate disease activity of rheumatoid arthritis (RA) and is a guide to treatment decision.The aim of this study was to evaluate the impact of lower reporting limit for C-reactive protein (CRP), with respect to intraindividual biological variability, on the calculation of DAS28 and subsequent patient classification.This study consists of 2 sections: a theoretical consideration discussing the performance of CRP in calculating DAS28 taking intraindividual biological variation and lower reporting limit for CRP into account and a cross-sectional study of RA patients applying our theoretical results. Therefore, we calculated DAS28 twice, with the actual CRP values and CRP = 9 mg/L, the latter to elucidate the positive effects of reducing the lower reporting limit of CRP from <10 to <3 mg/L.Lower-reporting limit of <10 mg/L leads to overestimate DAS28. However, reducing lower reporting limit for CRP to <3 mg/L results in optimizing DAS28 calculation. Further lowering of reporting limit for CRP to <3 mg/L does not increase the precision of DAS28 owing to the relatively large intraindividual biological variation.Five hundred twelve patients were included. There was a significant difference between recalculated and patients DAS28 (P < 0.001). One hundred nine patients had DAS28 deviation (compatible to remission to low: 66, low to moderate: 39. and moderate to high: 4).Owing to significant impact of intraindividual biologic variation on DAS28 and patient classification, special attention should be paid to calculate DAS28 when CRP values are within normal range. Furthermore, we conclude that results of different studies evaluating DAS28 and treatment response are not comparable if the reporting limits of CRP are unknown.

  17. No further gain can be achieved by calculating Disease Activity Score in 28 joints with high-sensitivity assay of C-reactive protein because of high intraindividual variability of C-reactive protein

    PubMed Central

    Hansen, Inger M.J.; Emamifar, Amir; Andreasen, Rikke A.; Antonsen, Steen

    2017-01-01

    Abstract Disease Activity Score in 28 joints (DAS28) is commonly used to evaluate disease activity of rheumatoid arthritis (RA) and is a guide to treatment decision. The aim of this study was to evaluate the impact of lower reporting limit for C-reactive protein (CRP), with respect to intraindividual biological variability, on the calculation of DAS28 and subsequent patient classification. This study consists of 2 sections: a theoretical consideration discussing the performance of CRP in calculating DAS28 taking intraindividual biological variation and lower reporting limit for CRP into account and a cross-sectional study of RA patients applying our theoretical results. Therefore, we calculated DAS28 twice, with the actual CRP values and CRP = 9 mg/L, the latter to elucidate the positive effects of reducing the lower reporting limit of CRP from <10 to <3 mg/L. Lower-reporting limit of <10 mg/L leads to overestimate DAS28. However, reducing lower reporting limit for CRP to <3 mg/L results in optimizing DAS28 calculation. Further lowering of reporting limit for CRP to <3 mg/L does not increase the precision of DAS28 owing to the relatively large intraindividual biological variation. Five hundred twelve patients were included. There was a significant difference between recalculated and patients DAS28 (P < 0.001). One hundred nine patients had DAS28 deviation (compatible to remission to low: 66, low to moderate: 39. and moderate to high: 4). Owing to significant impact of intraindividual biologic variation on DAS28 and patient classification, special attention should be paid to calculate DAS28 when CRP values are within normal range. Furthermore, we conclude that results of different studies evaluating DAS28 and treatment response are not comparable if the reporting limits of CRP are unknown. PMID:28072726

  18. In Vitro Efficacy of Diallyl Sulfides against the Periodontopathogen Aggregatibacter actinomycetemcomitans

    PubMed Central

    Ganeshnarayan, Krishnaraj; Velusamy, Senthil Kumar; Fine, Daniel H.

    2012-01-01

    The in vitro antibacterial effects of diallyl sulfide (DAS) against the Gram-negative periodontopathogen Aggregatibacter actinomycetemcomitans, the key etiologic agent of the severe form of localized aggressive periodontitis and other nonoral infections, were studied. A. actinomycetemcomitans was treated with garlic extract, allicin, or DAS, and the anti-A. actinomycetemcomitans effects of the treatment were evaluated. Garlic extract, allicin, and DAS significantly inhibited the growth of A. actinomycetemcomitans (greater than 3 log; P < 0.01) compared to control cells. Heat inactivation of the garlic extracts significantly reduced the protein concentration; however, the antimicrobial effect was retained. Purified proteins from garlic extract did not exhibit antimicrobial activity. Allicin lost all its antimicrobial effect when it was subjected to heat treatment, whereas DAS demonstrated an antimicrobial effect similar to that of the garlic extract, suggesting that the antimicrobial activity of garlic extract is mainly due to DAS. An A. actinomycetemcomitans biofilm-killing assay performed with DAS showed a significant reduction in biofilm cell numbers, as evidenced by both confocal microscopy and culture. Scanning electron microscopy (SEM) analysis of DAS-treated A. actinomycetemcomitans biofilms showed alterations of colony architecture indicating severe stress. Flow cytometry analysis of OBA9 cells did not demonstrate apoptosis or cell cycle arrest at therapeutic concentrations of DAS (0.01 and 0.1 μg/ml). DAS-treated A. actinomycetemcomitans cells demonstrated complete inhibition of glutathione (GSH) S-transferase (GST) activity. However, OBA9 cells, when exposed to DAS at similar concentrations, showed no significant differences in GST activity, suggesting that DAS-induced GST inhibition might be involved in A. actinomycetemcomitans cell death. These findings demonstrate that DAS exhibits significant antibacterial activity against A. actinomycetemcomitans and

  19. Stress-oriented driver assistance system for electric vehicles.

    PubMed

    Athanasiou, Georgia; Tsotoulidis, Savvas; Mitronikas, Epaminondas; Lymberopoulos, Dimitrios

    2014-01-01

    Stress is physiological and physical reaction that appears in highly demanding situations and affects human's perception and reaction capability. Occurrence of stress events within highly dynamic road environment could lead to life-threatening situation. With the perspective of safety and comfort driving provision to anxious drivers, in this paper a stress-oriented Driver Assistance System (DAS) is proposed. The DAS deployed on Electric Vehicle. This novel DAS customizes driving command signal in respect to road context, when stress is detected. The effectiveness of this novel DAS is verified by simulation in MATLAB/SIMULINK environment.

  20. Dietary aluminosilicate supplement enhances immune activity in mice and reinforces clearance of porcine circovirus type 2 in experimentally infected pigs.

    PubMed

    Jung, Bock-Gie; Toan, Nguyen Tat; Cho, Sun-Ju; Ko, Jae-hyung; Jung, Yeon-Kwon; Lee, Bong-Joo

    2010-07-14

    Aluminosilicate is the major component of clay minerals such as zeolite, bentonite and clinoptilolite. The minerals possess a number of beneficial activities, especially in regulating the immune system. The aims of the present study were to evaluate immune enhancing effects of dietary aluminosilicate supplement (DAS) in mice, and to demonstrate clearance effects of DAS against porcine circovirus type 2 (PCV2) in experimentally infected pigs as an initial step towards the development of an antibiotic substitute for use in pigs. Relative messenger RNA expression levels of interferon-gamma, interleukin-4 and tumor necrosis factor-alpha, phagocytic activities of polymorphonuclear leucocytes, serum antibody production level and spleen B cell ratio were significantly increased in the DAS groups of mice compared with the control group (each feeding group had three replications with 5 mice each). The results indicated that general immune activity including cellular and humoral immunity could be enhanced by DAS in mice. In experimentally PCV2-infected pigs, the load of viral genome in nasal swab, serum and lung of the DAS group of pigs was significantly decreased compared with the control group at 28 days post-infection (each group three pigs). Corresponding histopathological analyses demonstrated that pigs in the DAS group displayed mild and less severe abnormal changes compared with the control group, indicating that DAS reinforces clearance of PCV2 in experimentally infected pigs. This may relate to general immune enhancing effects of DAS in mice. Therefore DAS will help the health of animal, especially in swine.

  1. Streptomyces tritolerans sp. nov., a novel actinomycete isolated from soil in Karnataka, India.

    PubMed

    Syed, Dastager G; Agasar, Dayanand; Kim, Chang-Jin; Li, Wen-Jun; Lee, Jae-Chan; Park, Dong-Jin; Xu, Li-Hua; Tian, Xin-Peng; Jiang, Cheng-Lin

    2007-11-01

    A Gram-positive, nonmotile, moderately halophilic, alkali and thermotolerant strain designated DAS 165(T), was isolated from a dry land soil sample from the Gulbarga region, Karnataka province, India. The isolate produced yellow substrate mycelia and gray aerial mycelia on most tested media. Strain DAS 165(T) showed growth in the presence of 5 to 7% NaCl and at 45 degrees C. The DNA G + C content was 69.7%. 16S rRNA gene sequence analysis together with these characteristics consistently assigned strain DAS 165(T) to the genus Streptomyces. The 16S rRNA gene sequence analysis revealed that strain DAS 165(T) was most closely related to S. tendae ATCC 19812(T) (D 63873) with a sequence similarity of 99.6% (three nucleotide differences out of 1,517). Strain DAS 165(T) formed a distinct clade based on analysis of the almost complete sequence and 120-nucleotide variable gamma region of the 16S rRNA gene. Despite the high sequence similarity, strain DAS 165(T) was phenotypically different from S. tendae ATCC 19812(T). DNA-DNA hybridization between these strains was 47% showing that strain DAS 165(T) is a distinct genomic species. Phenetic and genetic results support the classification of strain DAS 165(T) as a new species, for which the name S. tritolerans is proposed, with strain DAS 165(T) as the type strain (=DSM 41899(T )= CCTCCAA 206013(T)).

  2. Konventionelle Dampfkraftwerke

    NASA Astrophysics Data System (ADS)

    Zahoransky, Richard; Allelein, Hans-Josef; Bollin, Elmar; Oehler, Helmut; Schelling, Udo

    Das Dampfkraftwerk beruht als thermisches Kraftwerk auf einem thermodynamischen Kreisprozess, der Wärme in technische Arbeit umwandelt. Die Arbeit wird mittels Elektrogenerator als elektrische Energie abgegeben.

  3. Effects of dialdehyde starch on calcification of collagen matrix.

    PubMed

    Liu, Yi; Acharya, Gayathri; Lee, Chi H

    2011-12-01

    Dialdehyde starch (DAS), a polymeric aldehyde derived from naturally occurring polysaccharide, was used as an additive to the collagen (COL) matrix in an effort to improve its physical and biological properties. The effects of DAS on the thermal stability of COL were characterized by differential scanning calorimetry. The conformational changes in COL were characterized by resistance to protease degradation assay, residual amine analysis, and Fourier-transform infrared spectroscopy. To assess biocompatibility enhancement, the calcium content in porcine aortic valve interstitial cells (PAVICs) on exposure to cardiovascular stents coated with DAS-stabilized COL was examined using atomic absorption spectroscopy. Thermal stability of DAS-stabilized COL was affected by DAS in a concentration dependent manner, reaching maximum at the saturation concentration (DAS:COL = 1:120) and decreasing the thermal stability at the concentrations above saturation. In the long-term exposure condition (21 days), stents coated with DAS at the lowest concentration significantly reduced the calcification rate of PAVIC, when compared with bare stent (p = 0.001). DAS appears to be an efficient additive to the COL matrix in improving its physical and biological properties. Further optimization process is needed for the suitable crosslinking conditions of DAS, which subsequently enhances thermal strength and anticalcification activities of COL matrix. Copyright © 2011 Wiley Periodicals, Inc.

  4. Exploring a new ultrasound score as a clinical predictive tool in patients with rheumatoid arthritis starting abatacept: results from the APPRAISE study

    PubMed Central

    D'Agostino, Maria-Antonietta; Boers, Maarten; Wakefield, Richard J; Berner Hammer, Hilde; Vittecoq, Olivier; Filippou, Georgios; Balint, Peter; Möller, Ingrid; Iagnocco, Annamaria; Naredo, Esperanza; Østergaard, Mikkel; Gaillez, Corine; Le Bars, Manuela

    2016-01-01

    Objectives To explore whether changes in a composite (power Doppler/greyscale ultrasound (PDUS)) synovitis score, developed by the OMERACT-EULAR-Ultrasound Task Force, predict disease activity outcomes in rheumatoid arthritis (RA). Methods Patients with RA who were methotrexate inadequate responders starting abatacept were evaluated. Individual joint PDUS scores were combined in the Global OMERACT-EULAR Synovitis Score (GLOESS) for metacarpophalangeal joints (MCPs) 2–5, all joints (22 paired) and a reduced (9 paired) joint set. The predictive value of changes in GLOESS at week 1–16 evaluations for clinical status and response (Disease Activity Score (DAS)28 (C reactive protein, CRP) <2.6; DAS28(CRP) ≤3.2; DAS28(CRP) ≥1.2 improvement) up to week 24, and correlations between DAS28 and GLOESS were assessed. Results Eighty-nine patients completed the 24-week treatment period. Changes in GLOESS (MCPs 2–5) from weeks 1 to 16 were unable to predict DAS28 outcomes up to week 24. However, significant improvements in GLOESS (MCPs 2–5) were observed at week 12 in patients with DAS28 ≥1.2 improvement at week 24 versus those who did not achieve that clinical response. In patients achieving DAS28 ≥1.2 improvement or DAS28 ≤3.2 at week 24, changes in GLOESS (22 and 9 paired joint sets) were greater in patients who already achieved DAS28 ≥1.2 at week 12 than in those who did not. No significant correlations were found between changes in DAS28 and GLOESS definitions at any time point. Conclusions PDUS was not correlated with clinical status or response as measured by DAS28-derived criteria, and PDUS changes were not predictive of clinical outcome. The discrepancies require further exploration. Trial registration number NCT00767325; Results. PMID:27175297

  5. Beginn des Studiums

    NASA Astrophysics Data System (ADS)

    Domnick, Ivonne

    Ihr Herz schlägt für die Naturwissenschaften? Die Arbeitsmarktaussichten sind gut. Das Studium einer der vier MINT-Disziplinen ist daher eine gute Investition in die Zukunft. Wie Sie erfolgreich in das Studium starten, erfahren Sie auf den folgenden Seiten.

  6. Screening for Aggression Using the Draw a Story Assessment. Brief Report

    ERIC Educational Resources Information Center

    Earwood, Cheryl; Fedorko, Melinda; Holzman, Eileen; Montanari, Linda; Silver, Rawley

    2004-01-01

    The purpose of this study was to find out if the Draw a Story (DAS) assessment can be used as a screening technique to identify children and adolescents at risk for aggression. Four art therapists presented the DAS tasks to 30 students with histories of aggressive behavior and to 181 students with no histories of aggression. After the 211…

  7. Propulsion and Power Rapid Response Research and Development Support: Delivery Order: Fundamental Science Investigations for Propulsion and Power Systems

    DTIC Science & Technology

    2009-01-01

    suspensions”, Applied Physics Letters, 2001, Vol. 79, No. 14, pp. 2252, 2254. Das, S.K., Putra , N., Roetzel, W., “Pool boiling characteristics of nanofluids...International Journal of Heat and Mass Transfer, 2003, Vol. 46, No. 5, pp. 851, 862. Das, S.K., Putra , N., Roetzel, W., “Pool boiling of

  8. 50 CFR 648.86 - NE Multispecies possession restrictions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... or area fished, or a vessel issued a Limited Access Incidental Catch Herring Permit and/or an Open... multispecies DAS, a limited access Handgear A permit, an open access Handgear B permit, or a monkfish limited... multispecies DAS, a limited access Handgear A permit, an open access Handgear B permit, or a monkfish limited...

  9. Multigroup Confirmatory Factor Analysis of U.S. and Italian Children's Performance on the PASS Theory of Intelligence as Measured by the Cognitive Assessment System

    ERIC Educational Resources Information Center

    Naglieri, Jack A.; Taddei, Stefano; Williams, Kevin M.

    2013-01-01

    This study examined Italian and U.S. children's performance on the English and Italian versions, respectively, of the Cognitive Assessment System (CAS; Naglieri & Conway, 2009; Naglieri & Das, 1997), a test based on a neurocognitive theory of intelligence entitled PASS (Planning, Attention, Simultaneous, and Successive; Naglieri & Das,…

  10. 77 FR 42699 - New England Fishery Management Council; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ... Director, New England Fishery Management Council; telephone: (978) 465-0492. SUPPLEMENTARY INFORMATION: The... modifications to the current days-at-sea (DAS) management system, including alternatives to enable DAS leasing... National Oceanic and Atmospheric Administration RIN 0648-XC116 New England Fishery Management...

  11. N-succinyl chitosan–dialdehyde starch hybrid hydrogels for biomedical applications

    PubMed Central

    Kamoun, Elbadawy A.

    2015-01-01

    A new class of injectable, biocompatible and biodegradable hydrogel is reported. This hydrogel is derived from N-succinyl chitosan (SCS) mixed with water-soluble dialdehyde starch (DAS) without using a conventional chemical crosslinker. The hybrid hydrogel is formed owing to the Schiff’s base reaction between amine groups of SCS and dialdehyde groups of DAS to form —CH 000000000000 000000000000 000000000000 111111111111 000000000000 111111111111 000000000000 000000000000 000000000000 N— group. SCS, DAS, and SCS–DAS hybrid hydrogels were synthesized and then characterized by FTIR analysis spectroscopy. The influence of SCS:DAS ratio in hybrid polymers solution on physicochemical properties of resultant hydrogels (e.g. gelation time, gel fraction (%) and equilibrium swelling ratio), surface morphology, in vitro weight loss (%), and mechanical stability was examined. The results demonstrated that SCS content has a profound role for forming tighter crosslinked hybrid hydrogels, where the increase of SCS content reduces the time for hydrogel forming. Also, the water uptake and hydrolytic weight loss decrease. Meanwhile, the DAS content increases, and mechanical properties of SCS–DAS hybrid hydrogels decrease. Curcumin release profile and adhered HGF cells on hydrogel surface sharply influenced the SCS portion in hybrid hydrogel composition. The SCS–DAS hybrid hydrogel properties afforded a possible opportunity to be used as a covalent in situ forming hybrid hydrogels in biomedical applications such as, tissue engineering and cartilage repair. PMID:26843972

  12. Theory in practice instead of theory versus practice--curricular design for task-based learning within a competency oriented curriculum.

    PubMed

    Rotthoff, Thomas; Schneider, Matthias; Ritz-Timme, Stefanie; Windolf, Joachim

    2015-01-01

    Zielsetzung: Medizinstudierende sollen bereits während ihres Studiums ärztliches Denken und Handeln intensiv trainieren und ihre klinische Expertise in theoretischer und praktischer Hinsicht entwickeln. Methodik: Ausgehend von den Erkenntnissen der Lehr- und Lernforschung wurde ein Curriculum für die klinisch-praktische Ausbildung im Modellstudiengang Düsseldorf entwickelt, welches auf das arbeitsplatzbezogene Lehren, Lernen und Prüfen fokussiert. Ergebnisse: Das Curriculum basiert für Studierende im 3, 4 und 5. Studienjahr wesentlich auf dem Lernen an Behandlungsanlässen von Patienten in multidisziplinären Bereichen der ambulanten und stationären Versorgung. Für dieses Lehrformat wurden 123 Behandlungsanlässe definiert und deren Verknüpfbarkeit mit Krankheitsbildern aus den verschiedenen Fachdisziplinen geprüft. Ausgehend vom Behandlungsanlass eines konkreten Falles, erarbeiten sich die Studierenden das zugrundeliegende Krankheitsbild sowie das differentialdiagnostische und therapeutische Vorgehen und vertiefen dabei das notwendige Wissen in den Grundlagenfächern. Zur Lernunterstützung wurden Studienbücher von den Kliniken erstellt. Das Lernen ist eingebunden in kompetenzorientiertes und arbeitsplatzbezogenes Lernen und Prüfen mit einer intensiven Kontaktzeit zwischen Studierenden und Ärzten.Schlussfolgerung: Das Konzept ermöglicht die Integration von Theorie in die Praxis sowie die Integration von Wissen aus den Grundlagen-, klinisch-theoretischen und klinischen Fächern in das ärztliche Denken und Handeln.

  13. 76 FR 61060 - Fisheries of the Northeastern United States; Northeast Multispecies Fishery; Correction to Cod...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    .... SUMMARY: NMFS is decreasing the Gulf of Maine and Georges Bank cod landing limit to 50 lb (22.7 kg) and 25..., 2011, decreased the GOM cod trip limit to 350 lb (158.8 kg) per DAS and the GB cod trip limit to 300 lb... consider future inseason adjustments to decrease the trip limit, or to increase differential DAS measures...

  14. Reexamination of the assessment criteria for rheumatoid arthritis disease activity based on comparison of the Disease Activity Score 28 with other simpler assessment methods.

    PubMed

    Fujiwara, Michio; Kita, Yasuhiko

    2013-03-01

    To explore simpler and possibly more appropriate tools than the conventional Disease Activity Score 28 (DAS28) for assessing rheumatoid arthritis (RA) and to derive more reliable DAS28-based criteria. The capabilities of assessing disease activities in 250 RA patients were compared between DAS28 and other methods, including the Simplified DA Index (SDAI), Clinical DA Index (CDAI), and Routine Assessment of Patient Index Data-3 (RAPID-3). SDAI and CDAI showed a good correlation and consistency with DAS28, whereas RAPID-3 yielded inferior results. In terms of remission criteria, DAS28 was less stringent than SDAI or CDAI; when RA remission was reexamined based on more stringent SDAI or CDAI criteria, cut-off values for DAS28-C-reactive protein of <1.72 were considered to be appropriate. The conventional DAS28 was considered to be appropriate for assessing low, middle and high disease activities because it provides criteria similar to or more stringent than those of other methods, while SDAI and CDAI were considered to be simpler and more appropriate criteria for assessing remission. For assessing remission, DAS28-CRP provides the most appropriate criterion of the methods compared when the currently used cut-off value of 2.3 is lowered to a new value of 1.72.

  15. Evaluating the Invariance and Validity of the Structure of Dysfunctional Attitudes in an Adolescent Population

    ERIC Educational Resources Information Center

    Prenoveau, Jason M.; Zinbarg, Richard E.; Craske, Michelle G.; Mineka, Susan; Griffith, James W.; Rose, Raphael D.

    2009-01-01

    Form A of the Dysfunctional Attitude Scale (DAS-A), a self-report measure of depressive beliefs, is widely used to test Beck's cognitive model of depression. The present study is the first to evaluate the DAS-A factor structure in an adolescent population of 542 high school juniors and the first to examine a hierarchical model. Findings support…

  16. AWARE: Adaptive Software Monitoring and Dynamic Reconfiguration for Critical Infrastructure Protection

    DTIC Science & Technology

    2015-04-29

    SECURITY CLASSIFICATION OF: The ARO-supported AWARE project addressed the design and performance of adaptive software technologies for highly trusted... software systems. A dynamically adaptive system (DAS) monitors itself and its execution environment at run time. This monitoring enables a DAS not only...Approved for Public Release; Distribution Unlimited Final Report: AWARE: Adaptive Software Monitoring and Dynamic Reconfiguration for Critical

  17. Optical Real Time Signal Processors and Semiconductor Surface and Semiconductor-Electrolyte Interface Study Using Acoustic Surface Wave.

    DTIC Science & Technology

    1981-08-01

    Resistivity GaAs", J. Appl. Phys., Vol. 50, pp. 4942-4950, 1979. Copies of the papers are available upon request. 2 5. J . Scott Moore and P. Das, "The...Papers presented with support from the contract 1. J . Scott Moore and P. Das, "Hot Electron Effects in Quasi-Two Dimensional Semiconductors

  18. Kommunikation in Automatisierungssystemen

    NASA Astrophysics Data System (ADS)

    Wellenreuther, Günter; Zastrow, Dieter

    Die Automatisierungstechnik befindet sich im Umbruch. Durch Anwendung moderner Kommunikationstechnik erhofft man sich entscheidende Verbesserungen bei Effizienz und Flexibilität der Automatisierungsprozesse. Der Begriff der Automatisierungstechnik umfasst heute mehr als nur das Automatisieren im Sinne von Steuern, Regeln und Visualisieren, eingeschlossen ist auch das Kommunizieren.

  19. Astrowissen. Zahlen - Daten - Fakten.

    NASA Astrophysics Data System (ADS)

    Keller, H.-U.

    This book is a completely revised and enlarged version of the 1994 edition (see Abstr. 61.003.081). Contents: Astronomie - die Wissenschaft vom Universum und seinen Sternen. Astronomische Instrumente. Sphärische Astronomie. Grundzüge der Himmelsmechanik. Das Sonnensystem. Stellarastronomie. Doppelsterne und Veränderliche. Sternhaufen und Assoziationen. Das Milchstraßensystem. Galaxien und Kosmologie. Meilensteine der Astronomie.

  20. N-succinyl chitosan-dialdehyde starch hybrid hydrogels for biomedical applications.

    PubMed

    Kamoun, Elbadawy A

    2016-01-01

    A new class of injectable, biocompatible and biodegradable hydrogel is reported. This hydrogel is derived from N-succinyl chitosan (SCS) mixed with water-soluble dialdehyde starch (DAS) without using a conventional chemical crosslinker. The hybrid hydrogel is formed owing to the Schiff's base reaction between amine groups of SCS and dialdehyde groups of DAS to form -CH 000000000000 000000000000 000000000000 111111111111 000000000000 111111111111 000000000000 000000000000 000000000000 N- group. SCS, DAS, and SCS-DAS hybrid hydrogels were synthesized and then characterized by FTIR analysis spectroscopy. The influence of SCS:DAS ratio in hybrid polymers solution on physicochemical properties of resultant hydrogels (e.g. gelation time, gel fraction (%) and equilibrium swelling ratio), surface morphology, in vitro weight loss (%), and mechanical stability was examined. The results demonstrated that SCS content has a profound role for forming tighter crosslinked hybrid hydrogels, where the increase of SCS content reduces the time for hydrogel forming. Also, the water uptake and hydrolytic weight loss decrease. Meanwhile, the DAS content increases, and mechanical properties of SCS-DAS hybrid hydrogels decrease. Curcumin release profile and adhered HGF cells on hydrogel surface sharply influenced the SCS portion in hybrid hydrogel composition. The SCS-DAS hybrid hydrogel properties afforded a possible opportunity to be used as a covalent in situ forming hybrid hydrogels in biomedical applications such as, tissue engineering and cartilage repair.

  1. Multigroup Confirmatory Factor Analysis of U.S. and Italian Children's Performance on the PASS Theory of Intelligence as Measured by the Cognitive Assessment System

    ERIC Educational Resources Information Center

    Naglieri, Jack A.; Taddei, Stefano; Williams, Kevin M.

    2013-01-01

    This study examined Italian and U.S. children's performance on the English and Italian versions, respectively, of the Cognitive Assessment System (CAS; Naglieri & Conway, 2009; Naglieri & Das, 1997), a test based on a neurocognitive theory of intelligence entitled PASS (Planning, Attention, Simultaneous, and Successive; Naglieri & Das,…

  2. 50 CFR 648.82 - Effort-control program for NE multispecies limited access vessels.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 2005 fishing years, Category A DAS are defined as 60 percent of the vessel's used DAS baseline... program described in this section, unless otherwise provided elsewhere in this part. (1) End-of-year carry...(a)(1)(i)(J), for the entire fishing year preceding the carry-over year, limited access vessels that...

  3. Token-to-Token Variability in Developmental Apraxia of Speech: Three Longitudinal Case Studies

    ERIC Educational Resources Information Center

    Marquardt, Thomas P.; Jacks, Adam; Davis, Barbara L.

    2004-01-01

    Variability in the speech production patterns of children with developmental apraxia of speech (DAS) was investigated in a three-year longitudinal study of three children with DAS. A metric was developed to measure token-to-token variability in repeated word productions from connected speech samples. Results suggest that high levels of total token…

  4. Prevalence of dental anomalies on panoramic radiographs in a population of the state of Pará, Brazil.

    PubMed

    Goncalves-Filho, Antonio Jg; Moda, Larissa B; Oliveira, Roberta P; Ribeiro, Andre Luis Ribeiro; Pinheiro, João Jv; Alver-Junior, S Rgio M

    2014-01-01

    Dental anomalies (DAs) are the result of disorders that are able to modify the shape, number, size, and structure of teeth. This study aimed to evaluate the prevalence of DAs using panoramic radiographs in a population of the City of Belém, northern Brazil. In this study, 487 panoramic radiographs were evaluated searching for DAs. Dental records were reviewed for diagnostic confirmation. DAs related to the shape, number, size, and structure of teeth were investigated. Our results showed a DA prevalence of 56.9%. The most prevalent DA was taurodontism, which was present in 27.19% of cases. Root dilaceration was the second most prevalent DA in adults, whereas hypodontia was the second most prevalent DA in children. A total of 13 DAs were found. Dental anomalies were present in over half of the sample, and most of them were related to the shape of the teeth. Although there was a high prevalence of shape-related DAs, these alterations are generally of lower severity, and most do not require specific treatment. However, in 19.25% of cases, DAs were found involving the number, size and structure of the teeth. These DAs should be diagnosed and treated early, avoiding thus more serious complications.

  5. Synthesis of radiolabeled mycotoxins. Annual report, 1 December 1985-30 November 1986

    SciTech Connect

    Kraus, G.A.

    1987-02-01

    The synthesis of labeled trichothecenes by degradation of diaceotxy scirpenol (DAS) is the subject of this report. The DAS was acetylated and deoxygenated to provide a diene which was selectively oxidized, deuterated, and epoxidized. This enone has been reduced. The remaining steps, separation and acetate removal, are in progress.

  6. An Exploratory Analysis of the Potential Association Between SCI Secondary Health Conditions and Daily Activities

    PubMed Central

    Cobb, John; Dumont, Frédéric S.; Leblond, Jean; Park, So Eyun; Noonan, Vanessa K.

    2014-01-01

    Background: Secondary health conditions (SHCs) are common following traumatic spinal cord injury (tSCI) and are believed to influence a person’s ability to participate in daily activities (DAs). This association should be understood so that health care providers may target interventions with clarity and purpose to manage SHCs and facilitate DAs to maximal effect. Objective: To explore the association between SHCs and DAs expressed as the increased chance of not participating as much as wanted in a DA when an SHC is present. Methods: Community-dwelling persons with tSCI (n = 1,137) responded to the SCI Community Survey. The occurrence and frequency of 21 SHCs were determined. The extent of participation in 26 DAs was measured. The relative risk (RR) of not participating as much as wanted in a DA when a SHC is present was calculated. Results: When some SHC were present, the RR of not participating as much as wanted increased significantly (range, 15%-153%; P < .001). Certain SHCs (light-headedness/dizziness, fatigue, weight problems, constipation, shoulder problems) were associated with a greater chance of not participating in many DAs. No single SHC was associated with every DA and conversely not every DA was associated with an SHC. Conclusions: Maximizing participation in DAs requires minimizing SHCs in every instance. Understanding the association between SHCs and DAs may facilitate targeted care resulting in less severe SHCs, greater participation in DAs, and benefits to both the individual and society. PMID:25477741

  7. Continuing German in Grade Five: MLA Teacher's Guide. A Course of Study Including Methods, Materials, and Aids for Teaching German to Fifth-Grade Pupils.

    ERIC Educational Resources Information Center

    Memming, Agnes K.; And Others

    This teacher's guide, for use in a fifth-grade German course, contains 12 units of instructional materials which concentrate on the development of basic audiolingual skills. Each of the units consists of conversational skits, dialogue adaptation, directed dialogue review, and classroom drills. Units include: (1) Das Aufstehen und das Fruhstuck,…

  8. The Dyadic Adjustment Scale: A Reliability Generalization Meta-Analysis

    ERIC Educational Resources Information Center

    Graham, James M.; Liu, Yenling J.; Jeziorski, Jennifer L.

    2006-01-01

    We conducted a reliability generalization meta-analysis to examine the internal consistency of Dyadic Adjustment Scale (DAS; Spanier, 1976) scores across 91 published studies with 128 samples and 25,035 participants. The DAS was found to produce total and Dyadic cohesion, Consensus, and Satisfaction scores of acceptable internal consistency,…

  9. Europäisches Organ der Festkörperforschung und DDR-Devisenbringer Die Zeitschrift Physica Status Solidi im Kalten Krieg

    NASA Astrophysics Data System (ADS)

    Hoffmann, Dieter

    Mit dem Ziele, ein einheitliches internationales Organ der Festkörperphysik für den europäischen Raum zu schaffen, das eine rasche Publikation der für das Festkörpergebiet repräsentative Arbeiten ermöglicht, wird durch ein internationales Herausgebergremium eine neue wissenschaftliche Zeitschrift gegründet.

  10. Depression and Anxiety Symptoms: Onset, Developmental Course and Risk Factors during Early Childhood

    ERIC Educational Resources Information Center

    Cote, Sylvana M.; Boivin, Michel; Liu, Xuecheng; Nagin, Daniel S.; Zoccolillo, Mark; Tremblay, Richard E.

    2009-01-01

    Background: Depressive and anxiety disorders are among the top ten leading causes of disabilities. We know little, however, about the onset, developmental course and early risk factors for depressive and anxiety symptoms (DAS). Objective: Model the developmental trajectories of DAS during early childhood and to identify risk factors for atypically…

  11. General Factor Loadings and Specific Effects of the Differential Ability Scales, Second Edition Composites

    ERIC Educational Resources Information Center

    Maynard, Jennifer L.; Floyd, Randy G.; Acklie, Teresa J.; Houston, Lawrence, III

    2011-01-01

    The purpose of this study was to investigate the "g" loadings and specific effects of the core and diagnostic composite scores from the Differential Abilities Scales, Second Edition (DAS-II; Elliott, 2007a). Scores from a subset of the DAS-II standardization sample for ages 3:6 to 17:11 were submitted to principal factor analysis. Four…

  12. Rheological characteristics and morphology of dialdehyde starch/meat composites during heating.

    PubMed

    Chiang, P Y; Li, J Y; Chen, M L

    2009-03-01

    Dialdehyde starch (DAS) was added to pork ham batter. The effects of DAS on the meat protein gel during heating were investigated using thermal and rheological analyses. In this study, the degree of DAS oxidation was controlled by the reaction time. The DSC thermogram showed that increasing the degree of oxidation resulted in DAS having a higher gelatinization temperature and lower heat absorption. In dialdehyde starch/meat (DAS/M) composites, meat protein reduced the availability of water to starch and raised the gelatinization temperature and heat absorbed by the composites. The G'(max) of the composites was greater than the linear combination of their components. The rheological properties of DAS were a major factor affecting the properties of its composites. Scanning electron microscopy and light microscopy with the aid of histologic technique revealed the network and distribution of DAS and DAS/M composites. The protein matrix formed the backbone of the network and gelatinized starch was trapped in the protein structure.

  13. Diallyl sulfide, diallyl disulfide, and diallyl trisulfide inhibit migration and invasion in human colon cancer colo 205 cells through the inhibition of matrix metalloproteinase-2, -7, and -9 expressions.

    PubMed

    Lai, Kuang-Chi; Hsu, Shu-Chun; Kuo, Chao-Lin; Yang, Jai-Sing; Ma, Chia-Yu; Lu, Hsu-Feng; Tang, Nou-Ying; Hsia, Te-Chun; Ho, Heng-Chien; Chung, Jing-Gung

    2013-09-01

    Diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS) are major organosulfur compounds exiting in garlic (Allium sativum). These compounds are reported to exhibit various pharmacological properties such as antibacteria, antiangiogenesis, anticancer, and anticoagulation, and they also induce cytotoxicity and induction of apoptosis in human cancer cells. Although these compounds show wide spectrum of biological activities, there are no reports to show that DAS, DADS, and DATS affected migration and invasion of human colon cancer cells, and their exact molecular mechanisms are not well investigated. Therefore, the purpose of this study was to determine whether DAS, DADS, and DATS affected the invasion and migration abilities of colo 205 human colon cancer cells. The results indicate that DAS, DADS, and DATS at 10 and 25 μM inhibited the migration and invasion of colo 205 cells in the order of DATS < DADS < DAS. DATS is the highest for inhibition of migration and invasion of colo 205 cells. DAS, DADS, and DATS induce downregulation expression of PI3K, Ras, MEKK3, MKK7, ERK1/2, JNK1/2, and p38 and then lead to the inhibition of MMP-2, -7, and -9. DAS, DADS, and DATS inhibited NF-κB and COX-2 for leading to the inhibition of cell proliferation. Taken together, these results demonstrated that application of DAS, DADS, and DATS might serve as potential antimetastatic drugs. Copyright © 2011 Wiley Periodicals, Inc., a Wiley company.

  14. 78 FR 34653 - Proposed Information Collection; Comment Request; Northeast Multispecies Days-at-Sea Leasing Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ... Multispecies Days-at-Sea Leasing Program AGENCY: National Oceanic and Atmospheric Administration (NOAA... (DAS) leasing requirements at Sec. 648.82(k) form the basis for this collection of information. The NE multispecies DAS leasing program was implemented in 2004 as a result of Amendment 13 (69 FR 22906)...

  15. 77 FR 26512 - Proposed Information Collection; Comment Request; Northeast Multispecies Days-at-Sea Leasing Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-04

    ... Multispecies Days-at-Sea Leasing Program AGENCY: National Oceanic and Atmospheric Administration (NOAA... (DAS) leasing requirements at Sec. 648.82(k) form the basis for this collection of information. The NE Multispecies DAS leasing program was implemented in 2004 as a result of Amendment 13 (69 FR 22906)...

  16. General Factor Loadings and Specific Effects of the Differential Ability Scales, Second Edition Composites

    ERIC Educational Resources Information Center

    Maynard, Jennifer L.; Floyd, Randy G.; Acklie, Teresa J.; Houston, Lawrence, III

    2011-01-01

    The purpose of this study was to investigate the "g" loadings and specific effects of the core and diagnostic composite scores from the Differential Abilities Scales, Second Edition (DAS-II; Elliott, 2007a). Scores from a subset of the DAS-II standardization sample for ages 3:6 to 17:11 were submitted to principal factor analysis. Four…

  17. Dysfunctional Attitudes and Suicidal Ideation in Psychiatric Outpatients.

    ERIC Educational Resources Information Center

    Beck, Aaron T.; And Others

    1993-01-01

    Administered Dysfunctional Attitude Scale (DAS), Beck Depression Inventory (BDI), Hopelessness Scale (BHS), Self-Concept Test (BST), and Scale for Suicide Ideation (SSI) to 908 psychiatric outpatients. Found that none of DAS subscales discriminated ideators and nonideators or was significantly related to SSI total scores of suicide ideators after…

  18. Tipps und Tricks

    NASA Astrophysics Data System (ADS)

    Häger, Wolfgang; Bauermeister, Dirk

    Hier wollen wir einige uns nützlich erscheinende Hinweise zur Arbeit mit dem Inventor geben. Dabei geht es vor allem darum, das Arbeiten mit dem Inventor zu vereinfachen. Die Beispiele stellen eine unvollständige Aufzählung dar und sollen dazu anregen, nach alternativen Vorgehensweisen zu suchen (hier sei noch einmal ausdrücklich auf das Internet verwiesen).

  19. Reply to "Comment on `Quantum Raychaudhuri equation'"

    NASA Astrophysics Data System (ADS)

    Das, Saurya

    2017-03-01

    The preceding Comment claims that the paper "Quantum Raychaudhuri equation" by S. Das, [Phys. Rev. D 89, 084068 (2014), 10.1103/PhysRevD.89.084068] has "problematic points" with regards to its derivation and implications. We show below that the above claim is incorrect, and that there are no problems with the results of Das's paper or its implications.

  20. Dimensionality of the Chinese Dyadic Adjustment Scale Based on Confirmatory Factor Analyses

    ERIC Educational Resources Information Center

    Shek, Daniel T. L.; Cheung, C. K.

    2008-01-01

    Based on the responses of 1,501 Chinese married adults to the Chinese version of the Dyadic Adjustment Scale (C-DAS), confirmatory factor analyses showed that four factors were abstracted from the C-DAS (Dyadic Consensus, Dyadic Cohesion, Dyadic Satisfaction and Affectional Expression) and these four primary factors were subsumed under a…

  1. Geschichte der geodätischen Instrumente und Verfahren im Altertumund Mittelalter.

    NASA Astrophysics Data System (ADS)

    Schmidt, F.

    Contents:A. Einleitung und allgemeiner Teil.B. Besonderer Teil:1. Nivellierinstrumente. 2. Instrumente zum Antragen eines rechten Winkels. 3. Längenmesser. 4. Stäbe und Stabzusammensetzungen als Instrumente zurmittelbaren Streckenbestimmung. 5. Die Instrumente mit dem Schattenquadrat: Das geometrische Quadrat. Das Astrolab. Der Quadrant. Anwendungen der Instrumente mit dem Schattenquadrat. 6. Der Jakobsstab. 7. Triangulationsinstrumente. 8. Schmiegen.

  2. Shared Decision Making and Patient Decision Aids: Knowledge, Attitudes, and Practices Among Hawai‘i Physicians

    PubMed Central

    Friend, John; Chun, Maria BJ

    2013-01-01

    Background: As the health care field moves toward patient-centered care (PCC), increasing emphasis has been placed on the benefits of patient decision aids for promoting shared decision making (SDM). This study provides a baseline measure of knowledge, attitudes, and practices (KAP) among Hawai‘i's physicians with respect to patient decision aids (DAs). Physicians throughout the State of Hawai‘i were invited to complete a survey assessing their knowledge, attitudes, and practices with respect to the clinical use of DAs. One hundred and seventy four valid surveys were analyzed. Reported awareness and use of DAs were low, but recognition of the benefits of SDM and openness to the use of DAs were very high. The leading perceived barriers to the implementation of DAs were lack of awareness, lack of resources, and limited physician time to learn about DA technology. However, a significant majority of the respondents reported that DAs could empower patients by improving knowledge (88%), increasing satisfaction with the consultation process (81%), and increasing compliance (74%). Among physicians currently employing DAs, use of brochures or options matrix sheets was the most common aid tool. However, leading recommended DA formats were paper-based brochures for clinic use (75%) and interactive online website programs for outside clinic use (73.5%). Given growing emphasis on the PCC model and the recognized desire of many patients to participate in the medical decision making process, positive responses toward SDM and the use of DAs by Hawai‘i physicians are promising. PMID:24251086

  3. 77 FR 38738 - Fisheries of the Northeastern United States; Northeast Multispecies Fishery; Exempted Fishery for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ...)(11), (b)(12), (c), (e), (h), and (i) of this section; or if fishing under a NE multispecies DAS; or... skate fishery. In addition, copies of this final rule and guide (i.e., permit holder letter) are... under a scallop DAS in accordance with paragraph (h) of this section; or if fishing under a General...

  4. 76 FR 56322 - Fisheries of the Northeastern United States; Northeast (NE) Multispecies Fishery; Framework...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... estimated that common pool catch of witch flounder would exceed the common pool sub-annual catch limit (sub... where witch flounder are predominately caught. The differential DAS rate applies to all Category A DAS... witch flounder was only exceeded by 20 percent, and the total ACL for northern windowpane flounder...

  5. 75 FR 4381 - Pesticide Experimental Use Permit; Receipt of Amendment and Extension Application; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    ... and Development (OECD) Unique Identifier: DAS-01507-1), Bacillus thuringiensis Cry34Ab1 and Cry35Ab1...-7 (OECD Unique Identifier: DAS-59122-7), Bacillus thuringiensis Cry1Ab delta-endotoxin protein and the genetic material necessary (vector pZO1502) for its production in corn event Bt11 (OECD Unique...

  6. Sensitivity Studies Using Multi-Region and Open Boundary Conditions for Terrain Bottom-Following Ocean Models

    DTIC Science & Technology

    2003-03-01

    Vol. 5, No. 1, 31-40, 1982. Fiuza, A. F. de G., Hidrologia e Dinamica das Aguas Costeiras de Portugal. Dissertacao apresentada a Universidade de...Upwelling: Its Sediment Record, part A, pp 85-97, Plenum, New York, 1983. Fiuza, A. F. G., Hidrologia e Dinamica das Aguas Costeiras de Portugal

  7. Potential of Diallyl Sulfide Bearing pH-Sensitive Liposomes in Chemoprevention Against DMBA-Induced Skin Papilloma

    PubMed Central

    Khan, Arif; Shukla, Yogeshwer; Kalra, Neetu; Alam, Maroof; Ahmad, Manzoor Gatoo; Hakim, Seema Rashid; Owais, Mohammad

    2007-01-01

    Diallyl sulfide (DAS), an active component of garlic, possesses strong anti-neoplastic properties against various forms of cancer. In the present study, we have evaluated chemo-preventive effects of liposomized DAS (conventional egg PC and pH-sensitive liposomes) against DMBA-induced skin papilloma. Various liposome-based novel formulations of DAS (250 μg/mouse) were applied topically, after one hour of exposure to DMBA (52 μg/mouse/dose), to the animals. The animals were treated thrice weekly for the total period of 12 weeks. The efficacy of the various liposomal formulations of DAS was evaluated on the basis of parameters such as incidence of tumorogenesis and total numbers and sizes of induced tumor nodules. The liposomized DAS formulations also were assessed for their effect on the expression of p53wt, p53mut, and p21/Waf1. The results of the present study showed that liposomized DAS could effectively delay the onset of tumorogenesis and reduce the cumulative numbers and sizes of tumor papillomas in treated mice. Treatment of DMBA-exposed animals with the liposomal formulation of DAS ensued in upregulation of p53wt and p21/Waf1, while levels of p53mut expression reduced down. The promising chemo-preventive nature of liposomal DAS may form the basis for establishing effective means of controlling various forms of cancer, including skin papilloma. PMID:17622315

  8. Verbrennungsmotoren

    NASA Astrophysics Data System (ADS)

    Schreiner, Klaus

    Das Kapitel "Verbrennungsmotoren" gibt eine Einführung in das wichte und große Gebiet der Verbrennungsmotoren. Leserinnen und Lesern, die noch nie etwas über Verbrennungsmotoren gehört haben, wird empfohlen, zunächst den Abschnitt 1 zu lesen. Dieser ist bewusst einfach und anschaulich geschrieben, um den Zugang zum Thema zu erleichtern. Danach können gezielt weitergehende Informationen in den Abschnitten 2 bis 9 studiert werden. Diese Abschnitte wurden so verfasst, dass man sie nicht nacheinander lesen muss. Grundlage ist jeweils nur der Abschnitt 1. Dieser selbst ist so verfasst, dass das Wichtigste ganz am Anfang steht. Je weiter hinten man in diesem Abschnitt ankommt, umso spezieller werden die Themen. Bei nur begrenztem Interesse an dem Thema Verbrennungsmotoren kann man das Lesen des Abschnitts 1 jederzeit abbrechen und hat trotzdem das bis dahin Wichtigste erfahren.

  9. Knowledge and attitudes of dental interns toward denture adhesives in King Saud University, Riyadh, Saudi Arabia

    PubMed Central

    Al Taweel, Sara Mohammad; Al Shehri, Huda Ahmed

    2016-01-01

    Objective: The objective of this study was to evaluate the knowledge and attitudes of dental interns at King Saud University College of Dentistry (KSUCD) regarding denture adhesives (DAs). Materials and Methods: Surveys were distributed to dental interns at KSUCD (n = 100). Cross-tabulations with the Pearson-™s Chi-square test were used to compare variables using the Statistical Package for Social Sciences (P ≤ 0.05). Results: Approximately, 85.5% of the respondents had learned about DAs as part of their undergraduate curriculum, 71% agree that DAs can be a beneficial adjunct in the fabrication of dentures, and 87% agree that dentists should routinely inform all denture patients of the proper use and misuse of DAs. Conclusion: Most of the participants have adequate knowledge and attitude toward DAs. PMID:28042271

  10. Knowledge and attitudes of dental interns toward denture adhesives in King Saud University, Riyadh, Saudi Arabia.

    PubMed

    Al Taweel, Sara Mohammad; Al Shehri, Huda Ahmed

    2016-01-01

    The objective of this study was to evaluate the knowledge and attitudes of dental interns at King Saud University College of Dentistry (KSUCD) regarding denture adhesives (DAs). Surveys were distributed to dental interns at KSUCD (n = 100). Cross-tabulations with the Pearson-™s Chi-square test were used to compare variables using the Statistical Package for Social Sciences (P ≤ 0.05). Approximately, 85.5% of the respondents had learned about DAs as part of their undergraduate curriculum, 71% agree that DAs can be a beneficial adjunct in the fabrication of dentures, and 87% agree that dentists should routinely inform all denture patients of the proper use and misuse of DAs. Most of the participants have adequate knowledge and attitude toward DAs.

  11. A New High Channel-Count, High Scan-Rate, Data Acquisition System for the NASA Langley Transonic Dynamics Tunnel

    NASA Technical Reports Server (NTRS)

    Ivanco, Thomas G.; Sekula, Martin K.; Piatak, David J.; Simmons, Scott A.; Babel, Walter C.; Collins, Jesse G.; Ramey, James M.; Heald, Dean M.

    2016-01-01

    A data acquisition system upgrade project, known as AB-DAS, is underway at the NASA Langley Transonic Dynamics Tunnel. AB-DAS will soon serve as the primary data system and will substantially increase the scan-rate capabilities and analog channel count while maintaining other unique aeroelastic and dynamic test capabilities required of the facility. AB-DAS is configurable, adaptable, and enables buffet and aeroacoustic tests by synchronously scanning all analog channels and recording the high scan-rate time history values for each data quantity. AB-DAS is currently available for use as a stand-alone data system with limited capabilities while development continues. This paper describes AB-DAS, the design methodology, and the current features and capabilities. It also outlines the future work and projected capabilities following completion of the data system upgrade project.

  12. Effectiveness of decision aids: a review of the evidence.

    PubMed

    Leatherman, Sheila; Warrick, Louise

    2008-12-01

    Increased interest in health care consumerism has created an environment conducive to growth in the use of decision aids (DAs) to support patient decision making. The authors review the research literature published within the past 5 years that assesses the effects of DAs in the areas of screening and treatment. Multiple measures are used to evaluate the effectiveness of DAs, with mixed evidence of impacts. To date, most evidence from screening studies suggests that DAs are effective in increasing knowledge and are acceptable to patients, but patient uptake of screening has been mixed. Among treatment studies, there is some, but limited, evidence showing impact of DAs on immediate and long-term decisional conflict, patient satisfaction, and quality of life. Few studies provide assessment of impact on health outcomes, quality of care, utilization, or costs, all areas likely to be of growing interest to private purchasers, insurers, and public programs.

  13. Moderating influence of dominant attentional style and exercise intensity on responses to asynchronous music.

    PubMed

    Hutchinson, Jasmin C; Karageorghis, Costas I

    2013-12-01

    We examined independent and combined influences of asynchronous music and dominant attentional style (DAS) on psychological and psychophysical variables during exercise using mixed methods. Participants (N = 34) were grouped according to DAS and completed treadmill runs at three intensities (low, moderate, high) crossed with three music conditions (motivational, oudeterous, no-music control). State attentional focus shifted from dissociative to associative with increasing intensity and was most aligned with DAS during moderate-intensity exercise. Both music conditions facilitated dissociation at low-to-moderate intensities. At high exercise intensity, both music conditions were associated with reduced RPE among participants with an associative DAS. Dissociators reported higher RPE overall during moderate and high intensities. Psychological responses were most positive in the motivational condition, followed by oudeterous and control. Findings illustrate the relevance of individual differences in DAS as well as task intensity and duration when selecting music for exercise.

  14. SNR characterization in distributed acoustic sensing

    NASA Astrophysics Data System (ADS)

    Gabai, Haniel; Eyal, Avishay

    2016-05-01

    In this paper we study the SNR associated with acoustic detection in Rayleigh-based Distributed Acoustic Sensing (DAS) systems. The study is focused on phase sensitive DAS due to its superiority in terms of linearity and sensitivity. Since DAS is based on coherent interference of backscattered light from multiple scatterers it is prone to signal fading. When left unresolved, the issue of signal fading renders the associated SNR randomly dependent on position and time. Hence, its proper measurement and characterization requires statistical tools. Here such tools are introduced and a methodology for finding the mean SNR and its distribution is implemented in both experiment and simulation. It is shown that the distribution of the DAS-SNR can be obtained from the distribution of backscattered power in OTDR and the mean DAS-SNR is proportional to the energy of the interrogation pulse.

  15. Ein Organic Computing Ansatz zur Steuerung einer sechsbeinigen Laufmaschine

    NASA Astrophysics Data System (ADS)

    Auf, Adam El Sayed; Larionova, Svetlana; Mösch, Florian; Litza, Marek; Jakimovski, Bojan; Maehle, Erik

    Obwohl die Rechengeschwindigkeit von Computern und die Komplexität unserer Systeme ständig zunimmt, sind die heutigen Laufmaschinen nicht in der Lage, sich mit den Fähigkeiten von Landtieren wie zum Beispiel Insekten zu messen. Das Verständnis biologischer Konzepte und das Lernen von der Natur könnten zur Verbesserung der heutigen Maschinen beitragen und sie ein wenig “lebensähnlicher“ machen. Dieser Artikel stellt einen Kontrollarchitekturansatz basierend auf “Organic Computing“-Prinzipien vor, der die Nutzung von Dezentralisierung und Selbstorganisation an einer sechsbeinigen Laufmaschine demonstriert. Die vorliegende Arbeit erklärt die elementaren Mechanismen für das gerade Laufen, das Kurvenlaufen sowie das Drehen auf der Stelle und den Umgang mit strukturellen körperlichen Änderungen wie einer Beinamputation und stellt die Ergebnisse experimenteller Versuche vor.

  16. Asbestos in toys: an exemplary case.

    PubMed

    Silvestri, Stefano; Di Benedetto, Francesco; Raffaell, Corrado; Veraldi, Angela

    2016-01-01

    DAS was an artificial clay which, once molded, hardened at room temperature. It was largely used as a toy between 1963 and 1975 in Italy, Netherlands, Germany, UK and Norway. This case report describes and reports the presence of asbestos in DAS. We investigated the presence of asbestos in DAS using light and electron microscopy on samples of the original material. We searched administrative documents at the State Archive of Turin and conducted interviews with past employees on annual production, suppliers, and purchasers. The analytical tests confirmed the presence of asbestos fibers in DAS: about 30% of its composition. The documents found at the State Archive confirmed the annual purchase of hundreds tons of raw asbestos from the Amiantifera di Balangero, the Italian asbestos mine. DAS was found to be used also within craftsmanship. Asbestos fibers in DAS may have caused exposure to production workers and a variety of users, including artists, teachers, and children. Over 13 years, about 55 million packs of DAS were produced and sold. The number of users is difficult to estimate but may have been in the order of millions. In Italy, a specific question on the use of DAS has been included in a routinely used mesothelioma questionnaire. As DAS was exported to other countries, our findings suggest that mesothelioma patients should be asked about their past use of DAS, in particular individuals not reporting a clear past asbestos exposure. Additionally, this discovery shows the incompleteness of records on asbestos uses and suggests to test items, including toys, imported from countries where asbestos is not forbidden.

  17. Characterization of red-near infrared transition for wheat and chickpea using 3 nm bandwidth data

    NASA Astrophysics Data System (ADS)

    Gupta, R. K.; Vijayan, D.; Prasad, T. S.

    2001-01-01

    Enhancement of space based capabilities to discriminate different crops and different varieties of a particular crop needs measurement of (i) the shift in red edge and (ii) the slope of the sudden rise of reflectance in 680 - 760 nm spectral region as a function of Days After Sowing (DAS). To develop the knowledge base for catering to the analysis of future space-based hyperspectral measurements, ground based measurements in 3 nm bandwidth in visible - near Infrared region together with corresponding Leaf Area Index (LAI) observations were taken over the Crop Growth Cycle (CGC) of Wheat and Chickpea. The red edge for wheat crop was at 679 nm for 25 DAS and reached the upper limit i.e., 693.7 nm at 84 DAS and thereafter shifted backward to 679 nm at 108 DAS. There was no change in red edge value of 684.9 nm during 40 to 49 DAS and of 687.8 nm during 55 to 71 DAS. The slope of Red to NIR transition for wheat varied from 0.457 to peak value of 0.784 during 25 to 71 DAS and thereafter decreased to 0.073 at 108 DAS. The peak of Red to Near Infrared (NIR) transition slope and Ratio Vegetation Index (RVI) occurred at the same time i.e., 71 DAS. However, the upper most value of red edge shift occurred at 84 DAS. Paper discusses the above aspects including role of mid point of Red to NIR transition, interrelationships among the Red-NIR transition Slope, Red Edge, LAI and RVI for wheat and chickpea.

  18. Studies on the immunochemical techniques for detection of selected fungal and dinoflagellate toxins. Annual progress report No. 2, 1 August 1982-31 July 1983

    SciTech Connect

    Chu, F.S.

    1983-08-15

    During the second year (August 1, 1982 to July 31, 1983), conditions for improving antibody production against T-2 toxin were studied. T-2 HS-BSA which has 10-15 moles of T-2 per mole of BSA was found to be a better immunogen than T-2-HG-BSA. Antibody titers as high as 11,000-14,000 were obtained from rabbits after repeated booster injections. High specific radioactive T-2, DAS, DOVE were prepared. With combination of the high specific radioactive T-2 toxin and high titer antibody, as little as 25 pg of T-2 toxin can be detected by the RIA in each assay. An indirect ELISA which permits detection of 0.2-1 ppb of T-2 toxin in urine, serum and milk was also established. Antibody against T-2 toxin was used to localize T-2 toxin in different tissues and organs of mice by an immunohistochemical technique. A collaborative study with Dr. Hunter revealed that antibody titers of T-2 toxin increased drastically in an immunomodulation system in mice. Titers as high as 50,000 were obtained in mice 10 days after immunization with T-2-HS-IgG (goat). Antibodies against diacetoxyscirpenol (DAS), and deoxyverrucarol (DOVE) were obtained from rabbits after immunizing with DAS-hemisuccinate (HS)-BSA, DAS-hemiglutarate (HG)-BSA and DOVE-HS-BSA. DAS-HG-BSA was found to be a better immunogen than DAS-HS-BSA for the production of antibody against DAS. The antibody for DAS is most specific for DAS. However, DOVE antidbodies were found to be less specific. Radioimmunoassays for both DAS and DOVE were established, and the detection limits were found.

  19. Sexual distress, sexual dysfunction and relationship quality in women with systemic sclerosis: correlation with clinical variables.

    PubMed

    Rosato, E; Rossi, C; Molinaro, I; Di Giulio, M A; Trombetta, A C; Marra, A M; Gigante, A; Barbano, B; Quarta, S; Pisarri, S; Afeltra, A; Salsano, F

    2014-01-01

    To assess the rate of sexual distress, sexual dysfunction and relationship quality and their association with clinical variables in women with systemic sclerosis (SSc), 102 sexually active women with SSc were recruited. Sexual distress, sexual dysfunction and dissatisfaction with relationship quality were investigated by Female Sexual Distress Scale Revised (FSDS-R), Female Sexual Function Index (FSFI) and Dyadic Adjustment Scale (DAS), respectively. The patients underwent medical examinations and nailfold videocapillaroscopy (NVC). Of the 102 patients, 37 (36%) reported sexual distress with FSDS-R score >11, 45 (44%) had sexual dysfunction with FSFI score <19 and 49 (48%) were not satisfied with relationship quality with DAS score <100. There was a negative correlation (p<0.001, R= -0.30) between FSDS-R and FSFI. No correlation was found between FSDS-R and DAS. FSFI showed a positive correlation with DAS (p<0.0001, R= 0.36). Age correlated negatively (p<0.05, R= -0.26) with FSFI, while FSDS-R and DAS did not correlate (p>0.05) with age. SSc women with digital ulcers (DU) had a reduction of FSFI and DAS compared with women without DU. In patients with late capillaroscopic pattern, mean value of FSFI was significantly lower than the other two capillaroscopic patterns. DAS decreased with progression of capillaroscopic damage. In a high percentage of women with SSc FSDS-R was increased, while FSFI and DAS were reduced. Age correlated negatively with FSFI, while skin score showed a negative correlation with DAS. Digital vascular damage negatively influenced FSFI and DAS.

  20. Rheumatologists' adherence to a disease activity score steered treatment protocol in early arthritis patients is less if the target is remission.

    PubMed

    Akdemir, G; Markusse, I M; Goekoop-Ruiterman, Y P M; Steup-Beekman, G M; Grillet, B A M; Kerstens, P J S M; Lems, W F; Huizinga, T W J; Allaart, C F

    2017-02-01

    To compare rheumatologists' adherence to treatment protocols for rheumatoid arthritis (RA) targeted at Disease Activity Score (DAS) ≤2.4 or <1.6. The BeSt-study enrolled 508 early RA (1987) patients targeted at DAS ≤2.4. The IMPROVED-study included 479 early RA (2010) and 122 undifferentiated arthritis patients targeted at DAS <1.6. We evaluated rheumatologists' adherence to the protocols and assessed associated opinions and conditions during 5 years. Protocol adherence was higher in BeSt than in IMPROVED (86 and 70 %), with a greater decrease in IMPROVED (from 100 to 48 %) than in BeSt (100 to 72 %). In BeSt, 50 % of non-adherence was against treatment intensification/restart, compared to 63 % in IMPROVED and 50 vs. 37 % were against tapering/discontinuation. In both studies, non-adherence was associated with physicians' disagreement with DAS or with next treatment step and if patient's visual analogue scale (VAS) for general health was ≥20 mm higher than the physician's VAS. In IMPROVED, also discrepancies between swelling, pain, erythrocyte sedimentation rate, and VASgh were associated with non-adherence. Adherence to DAS steered treatment protocols was high but decreased over 5 years, more in a DAS <1.6 steered protocol. Non-adherence was more likely if physicians disagreed with DAS or next treatment step. In the DAS <1.6 steered protocol, non-adherence was also associated with discrepancies between subjective and (semi)objective disease outcomes, and often against required treatment intensification. These results may indicate that adherence to DAS-steered protocols appears to depend in part on the height of the target and on how physicians perceive the DAS reflects RA activity.