Modeling resource basis for social and economic development strategies: Water resource case

NASA Astrophysics Data System (ADS)

Kosolapova, Natalia A.; Matveeva, Ludmila G.; Nikitaeva, Anastasia Y.; Molapisi, Lesego

2017-10-01

The article substantiates that the effectiveness of implementing socio-economic development strategies is to a large extent determined by the adequate provision of basic resources. The key role of water resources in economic strategic development is empirically illustrated. The article demonstrates the practicability of strategic management of water resources based on the principle of a combination of river basin management approaches and the consideration of regional development strategies. The Game Theory technique was used to develop economic and mathematical tools for supporting decision-making in meeting the needs of regional consumers under water balance deficit conditions. The choice of methods was determined from two positions: the methods should allow for the possibility of multi-variant solutions for the selection of optimal options for the distribution of limited water resources between different consumers; the methods should be orientated on the maximum possible harmonization of multidirectional and multi-scale interests of the subjects in the water management system of the different regions (including the state) in order to achieve a balance. The approbation of developing a toolkit for the example of the regions located in the Don and Kuban river basins resulted in the appropriate selection of priority regions for the allocation of water resources in terms of strategic management as well as the determination of measures of ensuring the sustainable use of the river basins under consideration. The proposed tools can be used for coordinating decisions on the water supply of regional economic systems with actual and projected indicators of socio-economic development of the respective regions for a strategic perspective.

Influence of natural factors on the quality of midwestern streams and rivers

USGS Publications Warehouse

Porter, Stephen D.; Harris, Mitchell A.; Kalkhoff, Stephen J.

2001-01-01

Streams flowing through cropland in the Midwestern Corn Belt differ considerably in their chemical and ecological characteristics, even though agricultural land use is highly intensive throughout the entire region. These differences likely are attributable to differences in riparian vegetation, soil properties, and hydrology. This conclusion is based on results from a study of the upper Midwest region conducted during seasonally low-flow conditions in August 1997 by the U.S. Geological Survey (USGS) National Water Quality Assessment (NAWQA) Program. This report summarizes significant results from the study and presents some implications for the design and interpretation of water-quality monitoring and assessment studies based on these results.

Molecular characterization of the canine mitochondrial DNA control region for forensic applications.

PubMed

Eichmann, Cordula; Parson, Walther

2007-09-01

The canine mitochondrial DNA (mtDNA) control region of 133 dogs living in the area around Innsbruck, Austria was sequenced. A total of 40 polymorphic sites were observed in the first hypervariable segment and 15 in the second, which resulted in the differentiation of 40 distinct haplotypes. We observed five nucleotide positions that were highly polymorphic within different haplogroups, and they represent good candidates for mtDNA screening. We found five point heteroplasmic positions; all located in HVS-I and a polythymine region in HVS-II, the latter often being associated with length heteroplasmy. In contrast to human mtDNA, the canine control region contains a hypervariable 10 nucleotide repeat region, which is located between the two hypervariable regions. In our population sample, we observed eight different repeat types, which we characterized by direct sequencing and fragment length analysis. The discrimination power of the canine mtDNA control region was 0.93, not taking the polymorphic repeat region into consideration.

Alleviating inequality in climate policy costs: an integrated perspective on mitigation, damage and adaptation

NASA Astrophysics Data System (ADS)

De Cian, E.; Hof, A. F.; Marangoni, G.; Tavoni, M.; van Vuuren, D. P.

2016-07-01

Equity considerations play an important role in international climate negotiations. While policy analysis has often focused on equity as it relates to mitigation costs, there are large regional differences in adaptation costs and the level of residual damage. This paper illustrates the relevance of including adaptation and residual damage in equity considerations by determining how the allocation of emission allowances would change to counteract regional differences in total climate costs, defined as the costs of mitigation, adaptation, and residual damage. We compare emission levels resulting from a global carbon tax with two allocations of emission allowances under a global cap-and-trade system: one equating mitigation costs and one equating total climate costs as share of GDP. To account for uncertainties in both mitigation and adaptation, we use a model-comparison approach employing two alternative modeling frameworks with different damage, adaptation cost, and mitigation cost estimates, and look at two different climate goals. Despite the identified model uncertainties, we derive unambiguous results on the change in emission allowance allocation that could lessen the unequal distribution of adaptation costs and residual damages through the financial transfers associated with emission trading.

FIRE aircraft observations of horizontal and vertical transport in marine stratocumulus

NASA Technical Reports Server (NTRS)

Paluch, Ilga R.; Lenschow, Donald H.

1990-01-01

A major goal of research on marine stratocumulus is to try to understand the processes that generate and dissipate them. One approach to studying this problem is to investigate the boundary layer structure in the vicinity of a transition from a cloudy to a cloud-free region to document the differences in structure on each side of the transition. Since stratiform clouds have a major impact on the radiation divergence in the boundary layer, the transition from a cloudy to a clear boundary layer is a region of large horizontal inhomogeneity in air temperature and turbulence intensity. This leads to a considerable difference in horizontal and vertical transports between the cloudy and cloud-free regions. Measurements are used from the NCAR Electra aircraft during flights 5 (7 July 1987) and 10 (18 July 1987) of FIRE for this purpose. Flight 5 coincided with a LANDSAT overflight, and was designed to investigate the transition across a well-defined N-S cloud boundary, since the LANDSAT image can document the cloud cover in considerable detail. Turbulence legs were flown about 60 km on both sides of the cloud boundary. Flight 10 was flown at night in an area of scattered small cumuli and broken cloud patches.

Journal Article: Quality Assurance Considerations for An Ambient Dioxin Monitoring Network

EPA Science Inventory

The U.S. Environmental Protection Agency initiated the National Dioxin Air Monitoring Network (NDAMN) in 1998. NDAMN has three primary purposes:
1. To provide measurements of background atmospheric levels of dioxin-like compounds in different geographic regions of the Unite...

Acoustic Detection of Insects in Palm Trees

USDA-ARS?s Scientific Manuscript database

Commercial-crop and ornamental palm trees serve important functions in tropical and subtropical regions of the world, and considerable precautions are taken each year to identify and control infestations of a variety of different insect pests. Large weevils, including the red palm weevil and the co...

Socioeconomic and Cultural Correlates of Diet Quality in the Canadian Arctic: Results from the 2007-2008 Inuit Health Survey.

PubMed

Galloway, Tracey; Johnson-Down, Louise; Egeland, Grace M

2015-09-01

We examined the impact of socioeconomic and cultural factors on dietary quality in adult Inuit living in the Canadian Arctic. Interviews and a 24-h dietary recall were administered to 805 men and 1292 women from Inuit regions in the Canadian Arctic. We examined the effect of age, sex, education, income, employment, and cultural variables on respondents' energy, macronutrient intake, sodium/potassium ratio, and healthy eating index. Logistic regression was used to assess the impact of socioeconomic status (SES) on diet quality indicators. Age was positively associated with traditional food (TF) consumption and greater energy from protein but negatively associated with total energy and fibre intake. Associations between SES and diet quality differed considerably between men and women and there was considerable regional variability in diet quality measures. Age and cultural variables were significant predictors of diet quality in logistic regression. Increased age and use of the Inuit language in the home were the most significant predictors of TF consumption. Our findings are consistent with studies reporting a nutrition transition in circumpolar Inuit. We found considerable variability in diet quality and complex interaction between SES and cultural variables producing mixed effects that differ by age and gender.

Fault detection for piecewise affine systems with application to ship propulsion systems.

PubMed

Yang, Ying; Linlin, Li; Ding, Steven X; Qiu, Jianbin; Peng, Kaixiang

2017-09-09

In this paper, the design approach of non-synchronized diagnostic observer-based fault detection (FD) systems is investigated for piecewise affine processes via continuous piecewise Lyapunov functions. Considering that the dynamics of piecewise affine systems in different regions can be considerably different, the weighting matrices are used to weight the residual of each region, so as to optimize the fault detectability. A numerical example and a case study on a ship propulsion system are presented in the end to demonstrate the effectiveness of the proposed results. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

Regional differences in the potential exposure of US minority populations to hazardous facilities

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nieves, L.A.; Nieves, A.L.

1992-01-01

In the literature that examines the distribution of environmental disamenities of various types, there is considerable documentation that minority groups and lower income groups are more likely to be exposed. Such differential exposure has been attributed to environmental racism'' by some authors, but there has been no systematic investigation of the factors and dynamics underlying this exposure pattern. This study examines regional differences in the proximity of African-American, Hispanics, Asians, and non-Hispanic Whites to a broad range facility types and explores the degree to which this may be related to urban and income factors.

Examining issues with water quality model configuration

USDA-ARS?s Scientific Manuscript database

Complex watershed–scale, water quality models require a considerable amount of data in order to be properly configured, especially in view of the scarcity of data in many regions due to temporal and economic constraints. In this study, we examined two different input issues incurred while building ...

Monitoring post-fire recovery of shrublands in Mediterranean-type ecosystems using MODIS and TM/ETM+ data

NASA Astrophysics Data System (ADS)

Hope, Allen; Albers, Noah; Bart, Ryan

2010-05-01

Wildland fires in Mediterranean-Type Ecosystems (MTEs) are episodic events that dramatically alter land-cover conditions. Monitoring post-fire vegetation recovery is important for land management applications such as the scheduling of prescribed burns, post-fire resource management and soil erosion control. Full recovery of MTE shrublands may take many years and have a prolonged effect on water, energy and carbon fluxes in these ecosystems. Comparative studies of fynbos ecosystems in the Cape Floristic Region of South Africa (Western Cape Region) and chaparral ecosystems of California have demonstrated that there is a considerable degree of convergence in some aspects of post-fire vegetation regeneration and marked differences in other aspects. Since these MTEs have contrasting rainfall and soil nutrient conditions, an obvious question arises as to the similarity or dissimilarity in remotely sensed post-fire recovery pathways of vegetation stands in these two regions and the extent to which fire severity and drought impact the rate of vegetation recovery. Post-fire recovery pathways of chaparral and fynbos vegetation stands were characterized using the normalized difference vegetation index (NDVI) based on TM/ETM+ and MODIS (250 m) data. Procedures based on stands of unburned vegetation (control) were implemented to normalize the NDVI for variations associated with inter-annual differences in rainfall. Only vegetation stands that had not burned for 20 years were examined in this study to eliminate potential effects of variable fire histories on the recovery pathways. Post-fire recovery patterns of vegetation in both regions and across different vegetation types were found to be very similar. Post-fire stand age was the primary control over vegetation recovery and the NDVI returned to pre-fire values within seven to 10 years of the fires. Droughts were shown to cause slight interruptions in recovery rates while fire severity had no discernable effect. Intra-stand variability in the NDVI (pixel-scale) also returned to pre-fire values within the same time frame but increased with water stress associated with droughts. While these studies indicated that the NDVI of fynbos and chaparral stands recovered to pre-fire values within 10 years, it is recognized that other ecosystem characteristics may take considerably longer to recover. Despite the larger pixel size, MODIS data were found to be more suitable for monitoring vegetation post-fire recovery than TM/ETM+ data, requiring considerably less pre-processing and providing substantially more information regarding phenological characteristics of recovery pathways. Future studies will include consideration of fire history in the post-fire recovery characteristics of vegetation in these two MTEs.

Transformation of environmental conditions in large former Soviet countries: regional analysis

NASA Astrophysics Data System (ADS)

Bityukova, V. R.; Borovikov, M. S.

2018-01-01

The article studies changes in the structure of environmental conditions of regions in the large former Soviet countries (case study of Russia and Kazakhstan) that have formed considerable contrasts in the placement of industrial complex and population settlement during the previous development stages. The changes related to the transition to market economy have led to essential transformation of environmental conditions. A complex index allowing to assess changes at the regional level in Kazakhstan and Russia and to reveal main similarities and differences between those changes is applied to studying the transformation of regional and industry structure. The article examines both industry-specific and spatial patterns forming environmental conditions at the regional level.

Where Does the Irrigation Water Go? An Estimate of the Contribution of Irrigation to Precipitation Using MERRA

NASA Technical Reports Server (NTRS)

Wei, Jiangfeng; Dirmeyer, Paul A.; Wisser, Dominik; Bosilovich, Michael G.; Mocko, David M.

2013-01-01

Irrigation is an important human activity that may impact local and regional climate, but current climate model simulations and data assimilation systems generally do not explicitly include it. The European Centre for Medium-Range Weather Forecasts (ECMWF) Interim Re-Analysis (ERA-Interim) shows more irrigation signal in surface evapotranspiration (ET) than the Modern-Era Retrospective Analysis for Research and Applications (MERRA) because ERA-Interim adjusts soil moisture according to the observed surface temperature and humidity while MERRA has no explicit consideration of irrigation at the surface. But, when compared with the results from a hydrological model with detailed considerations of agriculture, the ET from both reanalyses show large deficiencies in capturing the impact of irrigation. Here, a back-trajectory method is used to estimate the contribution of irrigation to precipitation over local and surrounding regions, using MERRA with observation-based corrections and added irrigation-caused ET increase from the hydrological model. Results show substantial contributions of irrigation to precipitation over heavily irrigated regions in Asia, but the precipitation increase is much less than the ET increase over most areas, indicating that irrigation could lead to water deficits over these regions. For the same increase in ET, precipitation increases are larger over wetter areas where convection is more easily triggered, but the percentage increase in precipitation is similar for different areas. There are substantial regional differences in the patterns of irrigation impact, but, for all the studied regions, the highest percentage contribution to precipitation is over local land.

The structure and evolution of ancient impact basins on Mars

NASA Technical Reports Server (NTRS)

Schultz, P. H.; Schultz, R. A.; Rogers, J.

1982-01-01

It is pointed out that characteristic styles of degradation and modification of obvious Martian basins make it possible to recognize more subtle expressions. This approach is seen as providing not only additional basins to the existing inventory but also fundamental clues for initial impact basin structure and stratigraphy. It also reveals the long-lasting influence of basin formation on the crust of Mars in spite of extensive erosion and resurfacing. Consideration is given to five clear examples of modified impact basins, and regions around each that have undergone similar processes (fracturing, collapse, channeling) are delineated. These processes among the different basins are then compared, and similar zones of modification are correlated with concentric basin rings. Consideration is then given to the implications of these observations for current models of basin formation and to the role of impact basins in controlling regional tectonics. The results indicate that large multiring impact scars leave a major but sometimes subtle imprint on the geologic structure of stable crustal regions on Mars.

Uncertainties in Earthquake Loss Analysis: A Case Study From Southern California

NASA Astrophysics Data System (ADS)

Mahdyiar, M.; Guin, J.

2005-12-01

Probabilistic earthquake hazard and loss analyses play important roles in many areas of risk management, including earthquake related public policy and insurance ratemaking. Rigorous loss estimation for portfolios of properties is difficult since there are various types of uncertainties in all aspects of modeling and analysis. It is the objective of this study to investigate the sensitivity of earthquake loss estimation to uncertainties in regional seismicity, earthquake source parameters, ground motions, and sites' spatial correlation on typical property portfolios in Southern California. Southern California is an attractive region for such a study because it has a large population concentration exposed to significant levels of seismic hazard. During the last decade, there have been several comprehensive studies of most regional faults and seismogenic sources. There have also been detailed studies on regional ground motion attenuations and regional and local site responses to ground motions. This information has been used by engineering seismologists to conduct regional seismic hazard and risk analysis on a routine basis. However, one of the more difficult tasks in such studies is the proper incorporation of uncertainties in the analysis. From the hazard side, there are uncertainties in the magnitudes, rates and mechanisms of the seismic sources and local site conditions and ground motion site amplifications. From the vulnerability side, there are considerable uncertainties in estimating the state of damage of buildings under different earthquake ground motions. From an analytical side, there are challenges in capturing the spatial correlation of ground motions and building damage, and integrating thousands of loss distribution curves with different degrees of correlation. In this paper we propose to address some of these issues by conducting loss analyses of a typical small portfolio in southern California, taking into consideration various source and ground motion uncertainties. The approach is designed to integrate loss distribution functions with different degrees of correlation for portfolio analysis. The analysis is based on USGS 2002 regional seismicity model.

Posterior Rigid Instrumentation of C7: Surgical Considerations and Biomechanics at the Cervicothoracic Junction. A Review of the Literature.

PubMed

Bayoumi, Ahmed B; Efe, Ibrahim E; Berk, Selim; Kasper, Ekkehard M; Toktas, Zafer Orkun; Konya, Deniz

2018-03-01

The cervicothoracic junction is a challenging anatomic transition in spine surgery. It is commonly affected by different types of diseases that may significantly impair stability in this region. The seventh cervical vertebra (C7) is an atypical cervical vertebra with unique anatomic features compared to subaxial cervical spine (C3 to C6). C7 has relatively broader laminae, larger pedicles, smaller lateral masses, and a long nonbifid spinous process. These features allow a variety of surgical methods for performing posterior rigid instrumentation in the form of different types of screws, such as lateral mass screws, pedicle screws, transfacet screws, and intralaminar screws. Many biomechanical studies on cadavers have evaluated and compared different types of implants at C7. We reviewed PubMed/Medline by using specific combinations of keywords to summarize previously published articles that examined C7 posterior rigid instrumentation thoroughly in an experimental fashion on patients or cadavers with additional descriptive radiologic parameters for evaluation of the optimum surgical technique for each type. A total of 44 articles were reported, including 22 articles that discussed anatomic considerations (entry points, sagittal and axial trajectories, and features of screws) and another 22 articles that discussed the relevant biomechanical testing at this transitional region if C7 was directly involved in terms of receiving posterior rigid implants. C7 can accommodate different types of screws, which can provide additional benefits and risks based on availability of bony purchase, awareness of surgical technique, biomechanics, and anatomic considerations. Copyright © 2017 Elsevier Inc. All rights reserved.

Antibodies in sera from camels (Camelus dromedarius) in western and sothren regions of Central Province, Saudi Arabia.

PubMed

Al-Anazi, Abdullah D

2012-12-01

The study evaluated the seroprevalence of Toxoplasma gondii in domestic camels in Western and Southern regions of Central province of Saudi Arabia. In total, 713 serum samples from clinically healthy camels were analyzed for anti-T. gondii antibodies using the Latex agglutination test (LAT). Antibodies to T. gondii were found in 94 (13.1%) camels. The number of seropositive in Al-Quwayiyah region (16.9%) was considerably higher than in other regions. However, the differences in seroprevalence between the 4 regions were not statistically significant (P >. 0.05). These results indicate that T. gondii antibodies are widespread in the camel populations and suggest that toxoplasmosis is a widely spread zoonotic infection this region.

Temporally Graded Activation of Neocortical Regions in Response to Memories of Different Ages

PubMed Central

Woodard, John L.; Seidenberg, Michael; Nielson, Kristy A.; Miller, Sarah K.; Franczak, Malgorzata; Antuono, Piero; Douville, Kelli L.; Rao, Stephen M.

2007-01-01

The temporally graded memory impairment seen in many neurobehavioral disorders implies different neuroanatomical pathways and/or cognitive mechanisms involved in storage and retrieval of memories of different ages. A dynamic interaction between medial-temporal and neocortical brain regions has been proposed to account for memory’s greater permanence with time. Despite considerable debate concerning its time-dependent role in memory retrieval, medial-temporal lobe activity has been well studied. However, the relative participation of neocortical regions in recent and remote memory retrieval has received much less attention. Using functional magnetic resonance imaging, we demonstrate robust, temporally graded signal differences in posterior cingulate, right middle frontal, right fusiform, and left middle temporal regions in healthy older adults during famous name identification from two disparate time epochs. Importantly, no neocortical regions demonstrated greater response to older than to recent stimuli. Our results suggest a possible role of these neocortical regions in temporally dating items in memory and in establishing and maintaining memory traces throughout the lifespan. Theoretical implications of these findings for the two dominant models of remote memory functioning (Consolidation Theory and Multiple Trace Theory) are discussed. PMID:17583988

Socioeconomic inequalities in occupational, leisure-time, and transport related physical activity among European adults: A systematic review

PubMed Central

2012-01-01

Background This study systematically reviewed the evidence pertaining to socioeconomic inequalities in different domains of physical activity (PA) by European region. Methods Studies conducted between January 2000 and December 2010 were identified by a systematic search in Pubmed, Embase, Web of Science, Psychinfo, Sportdiscus, Sociological Abstracts, and Social Service Abstracts. English-language peer-reviewed studies undertaken in the general population of adults (18–65 years) were classified by domain of PA (total, leisure-time including sport, occupational, active transport), indicator of socioeconomic position (education, income, occupation), and European region. Distributions of reported positive, negative, and null associations were evaluated. Results A total of 131 studies met the inclusion criteria. Most studies were conducted in Scandinavia (n = 47). Leisure-time PA was the most frequently studied PA outcome (n = 112). Considerable differences in the direction of inequalities were seen for the different domains of PA. Most studies reported that those with high socioeconomic position were more physically active during leisure-time compared to those with low socioeconomic position (68% positive associations for total leisure-time PA, 76% for vigorous leisure-time PA). Occupational PA was more prevalent among the lower socioeconomic groups (63% negative associations). Socioeconomic differences in total PA and active transport PA did not show a consistent pattern (40% and 38% positive associations respectively). Some inequalities differed by European region or socioeconomic indicator, however these differences were not very pronounced. Conclusions The direction of socioeconomic inequalities in PA in Europe differed considerably by domain of PA. The contradictory results for total PA may partly be explained by contrasting socioeconomic patterns for leisure-time PA and occupational PA. PMID:22992350

The road to reorganization. A system keeps its regional network all in the family.

PubMed

Haglund, C

1989-11-01

One prominent strategy health-care institutions are pursuing today is the formation of regional networks providing comprehensive continuums of care. Regional activities can be organized according to several distinct geographical parameters: city, county, state, or multistate regions. Although the different types of regionalization may be beneficial, they will generate different types of activities and benefits. Another consideration is that regional structures can range from very loose affiliations to complete ownership. In 1987 the Sisters of Providence health system, Seattle, initiated efforts to create a functionally integrated regional healthcare system in the Portland, OR, market, which had a good framework in place for developing a vertically and horizontally linked comprehensive continuum of care. The Oregon Management Committee, composed of local administrators, was established to identify issues and develop common objectives. The group developed a regional strategic plan and identified eight key areas to begin regionally coordinated activities. It began creating working relationships among institutional counterparts and program integration in several outpatient service areas where duplication was evident. Another effort involved greater coordination of marketing activities.

Examining Regionalization Efforts to Develop Lessons Learned and Consideration for Department of Defense Medical Facilities

DTIC Science & Technology

2017-03-23

Consideration for Department of Defense Medical Facilities Erik B. Schuh Follow this and additional works at: https://scholar.afit.edu/etd Part of the...Citation Schuh, Erik B., "Examining Regionalization Efforts to Develop Lessons Learned and Consideration for Department of Defense Medical Facilities...Consideration for Department of Defense Medical Facilities THESIS Erik B. Schuh, 2Lt, USAF AFIT-ENS-MS-17-M-156 DEPARTMENT OF THE AIR FORCE AIR UNIVERSITY AIR

Ecosystem-based fisheries management: Perception on definitions, implementations, and aspirations.

PubMed

Trochta, John T; Pons, Maite; Rudd, Merrill B; Krigbaum, Melissa; Tanz, Alexander; Hilborn, Ray

2018-01-01

Ecosystem-based fisheries management (EBFM) was developed to move beyond single species management by incorporating ecosystem considerations for the sustainable utilization of marine resources. Due to the wide range of fishery characteristics, including different goals of fisheries management across regions and species, theoretical best practices for EBFM vary greatly. Here we highlight the lack of consensus in the interpretation of EBFM amongst professionals in marine science and its implementation. Fisheries policy-makers and managers, stock assessment scientists, conservationists, and ecologists had very different opinions on the degree to which certain management strategies would be considered EBFM. We then assess the variability of the implementation of EBFM, where we created a checklist of characteristics typifying EBFM and scored fisheries across different regions, species, ecosystems, and fishery size and capacity. Our assessments show fisheries are unlikely to meet all the criteria on the EBFM checklist. Consequentially, it is unnecessary for management to practice all the traits of EBFM, as some may be disparate from the ecosystem attributes or fishery goals. Instead, incorporating some ecosystem-based considerations to fisheries management that are context-specific is a more realistic and useful way for EBFM to occur in practice.

Ecosystem-based fisheries management: Perception on definitions, implementations, and aspirations

PubMed Central

Hilborn, Ray

2018-01-01

Ecosystem-based fisheries management (EBFM) was developed to move beyond single species management by incorporating ecosystem considerations for the sustainable utilization of marine resources. Due to the wide range of fishery characteristics, including different goals of fisheries management across regions and species, theoretical best practices for EBFM vary greatly. Here we highlight the lack of consensus in the interpretation of EBFM amongst professionals in marine science and its implementation. Fisheries policy-makers and managers, stock assessment scientists, conservationists, and ecologists had very different opinions on the degree to which certain management strategies would be considered EBFM. We then assess the variability of the implementation of EBFM, where we created a checklist of characteristics typifying EBFM and scored fisheries across different regions, species, ecosystems, and fishery size and capacity. Our assessments show fisheries are unlikely to meet all the criteria on the EBFM checklist. Consequentially, it is unnecessary for management to practice all the traits of EBFM, as some may be disparate from the ecosystem attributes or fishery goals. Instead, incorporating some ecosystem-based considerations to fisheries management that are context-specific is a more realistic and useful way for EBFM to occur in practice. PMID:29381700

Investigation of methanogenic community structures in rural biogas digesters from different climatic regions in Yunnan, southwest China.

PubMed

Dong, Minghua; Wu, Yan; Li, Qiumin; Tian, Guangliang; Yang, Bin; Li, Yingjuan; Zhang, Lijuan; Wang, Yongxia; Xiao, Wei; Yin, Fang; Zhao, Xingling; Zhang, Wudi; Cui, Xiaolong

2015-05-01

Understanding of the microbial community structures of the biogas digesters in different climatic regions can help improve the methane production in the fermentation process. The methanogenic archaeal diversity in four rural biogas digesters (BNA, JSA, LJA, and XGA) was investigated by a culture-independent rRNA approach in different climatic regions in Yunnan. Community structure composed of 711 clones in the all libraries. A total of 33 operational taxonomic units (OTUs) were detected, and major groups of methanogens were the orders Methanosarcinales and Methanomicrobiales. 63.2 % of all archaeal OTUs belong to the order Methanosarcinales which mostly contain acetotrophic methanogens. Methanomicrobiales (19.5 % in all OTUs) were detected in considerable number. Additionally, there were minor rates of uncultured archaea. The principal component analysis indicated that the genus Methanosaeta was mainly affected by the fermentation temperatures.

Complex Building Detection Through Integrating LIDAR and Aerial Photos

NASA Astrophysics Data System (ADS)

Zhai, R.

2015-02-01

This paper proposes a new approach on digital building detection through the integration of LiDAR data and aerial imagery. It is known that most building rooftops are represented by different regions from different seed pixels. Considering the principals of image segmentation, this paper employs a new region based technique to segment images, combining both the advantages of LiDAR and aerial images together. First, multiple seed points are selected by taking several constraints into consideration in an automated way. Then, the region growing procedures proceed by combining the elevation attribute from LiDAR data, visibility attribute from DEM (Digital Elevation Model), and radiometric attribute from warped images in the segmentation. Through this combination, the pixels with similar height, visibility, and spectral attributes are merged into one region, which are believed to represent the whole building area. The proposed methodology was implemented on real data and competitive results were achieved.

Are Rural Development Programmes Socially Inclusive? Social Inclusion, Civic Engagement, Participation, and Social Capital: Exploring the Differences

ERIC Educational Resources Information Center

Shortall, Sally

2008-01-01

Considerable importance is attached to social exclusion/inclusion in recent EU rural development programmes. At the national/regional operation of these programmes groups of people who are not participating are often identified as "socially excluded groups". This article contends that rural development programmes are misinterpreting the…

Matching is not naming: a direct comparison of lexical manipulations in explicit and implicit reading tasks.

PubMed

Vogel, Alecia C; Petersen, Steven E; Schlaggar, Bradley L

2013-10-01

The neurobiological basis of reading is of considerable interest, yet analyzing data from subjects reading words aloud during functional MRI data collection can be difficult. Therefore, many investigators use surrogate tasks such as visual matching or rhyme matching to eliminate the need for spoken output. Use of these tasks has been justified by the presumption of "automatic activation" of reading-related neural processing when a word is viewed. We have tested the efficacy of using a nonreading task for studying "reading effects" by directly comparing blood oxygen level dependent (BOLD) activity in subjects performing a visual matching task and an item naming task on words, pseudowords (meaningless but legal letter combinations), and nonwords (meaningless and illegal letter combinations). When compared directly, there is significantly more activity during the naming task in "reading-related" regions such as the inferior frontal gyrus (IFG) and supramarginal gyrus. More importantly, there are differing effects of lexicality in the tasks. A whole-brain task (matching vs. naming) by string type (word vs. pseudoword vs. nonword) by BOLD timecourse analysis identifies regions showing this three-way interaction, including the left IFG and left angular gyrus (AG). In the majority of the identified regions (including the left IFG and left AG), there is a string type × timecourse interaction in the naming but not the matching task. These results argue that the processing performed in specific regions is contingent on task, even in reading-related regions and is thus nonautomatic. Such differences should be taken into consideration when designing studies intended to investigate reading. Copyright © 2012 Wiley Periodicals, Inc.

Experimental infections of wild bank voles (Myodes glareolus) from nephropatia epidemica endemic and non-endemic regions revealed slight differences in Puumala virological course and immunological responses.

PubMed

Dubois, Adélaïde; Castel, Guillaume; Murri, Séverine; Pulido, Coralie; Pons, Jean-Baptiste; Benoit, Laure; Loiseau, Anne; Lakhdar, Latifa; Galan, Maxime; Charbonnel, Nathalie; Marianneau, Philippe

2017-05-02

In Europe, the occurrence of nephropathia epidemica (NE), a human disease caused by Puumala virus (PUUV), exhibits considerable geographical heterogeneity despite the continuous distribution of its reservoir, the bank vole Myodes glareolus. To better understand the causes of this heterogeneity, wild voles sampled in two adjacent NE endemic and non-endemic regions of France were infected experimentally with PUUV. The responses of bank voles to PUUV infection, based on the levels of anti-PUUV IgG and viral RNA, were compared. Slight regional differences were highlighted despite the high inter-individual variability. Voles from the NE non-endemic region showed greater immune responsiveness to PUUV infection, but lower levels of RNA in their organs than voles from the endemic region. These results suggest the existence of regional variations in the sensitivity of bank voles that could contribute to the apparent absence of PUUV circulation among voles and the absence of NE in the non-endemic region. Copyright © 2017 Elsevier B.V. All rights reserved.

Opioid Use in the Twenty First Century: Similarities and Differences Across National Borders

PubMed Central

Vasilev, Georgi; Milcheva, Svetla; Vassileva, Jasmin

2016-01-01

Opinion Statement The global prevalence in the use of opiates and opioids has remained stable, though there were some unprecedented recent increases in opioid use and associated mortality and morbidity in the United States. Internationally, there is a strong tendency for consolidation of drug treatment strategies in favor of more systematic, structured and balanced approaches to regional and national drug policies. However, there are considerable differences in the scope, focus, and implementation of national drug policies and the political context is shaping drug prevention, treatment and rehabilitation efforts to an extent not typically observed in other public health domains. As a result, though in theory, there is a considerable multi-national agreement about the efficacy and effectiveness of different treatment modalities for opioid dependence, in practice, there are striking differences among different world regions and countries in the degree of implementation of these treatment modalities into clinical practice. Such discrepancies between theory and practice are observed even in high-income countries such as the United States and European Union member states, where evidence-based treatment modalities are still not well implemented into clinical practice. Despite the lack of evidence-based support for the role of detoxification as a stand-alone treatment for opioid use disorders, it appears to be the most widely used intervention for opioid use across the world. PMID:27493878

How much water do we need for irrigation under Climate Change in the Mediterranean?

NASA Astrophysics Data System (ADS)

Fader, Marianela; Alberte, Bondeau; Wolfgang, Cramer; Simon, Decock; Sinan, Shi

2014-05-01

Anthropogenic climate change will very likely alter the hydrological system of already water-limited agricultural landscapes around the Mediterranean. This includes the need for, as well as the availability of irrigation water. On top of that Mediterranean agroecosystems are very likely to be under strong pressure in the near future through changes in consumer demands and diets, increasing urbanization, demographic change, and new markets for agricultural exportation. As a first step to assess the water demand of the agricultural sector, we use an ecohydrological model (the Lund-Potsdam-Jena managed land model, LPJmL) to estimate current and future irrigation water requirements of this region, considering various climate and socio-economic scenarios. LPJmL is a process-based, agricultural and water balance model, where plant growth is ecophysiologically coupled with hydrological variables. For these simulations, the model was adapted to the Mediterranean region in terms of agrosystems as well as crop parameters, and a sensitivity analysis for the irrigation system efficiency was performed. Patterns of current irrigation water requirements differ strongly spatially within the Mediterranean region depending mainly on potential evapotranspiration, the combination of crops cultivated and the extension of irrigated areas. The simulations for the future indicate that the Mediterranean may need considerable additional amounts of irrigation water. However, the regional patterns differ strongly depending on changes in length of growing periods, changes in transpirational rate (temperature and precipitation change, CO2-fertilization), and the consideration of potential improvements in irrigation system efficiency.

Natural and anthropogenic land cover change and its impact on the regional climate and hydrological extremes over Sanjiangyuan region

NASA Astrophysics Data System (ADS)

Ji, P.; Yuan, X.

2017-12-01

Located in the northern Tibetan Plateau, Sanjiangyuan is the headwater region of the Yellow River, Yangtze River and Mekong River. Besides climate change, natural and human-induced land cover change (e.g., Graze for Grass Project) is also influencing the regional hydro-climate and hydrological extremes significantly. To quantify their impacts, a land surface model (LSM) with consideration of soil moisture-lateral surface flow interaction and quasi-three-dimensional subsurface flow, is used to conduct long-term high resolution simulations driven by China Meteorological Administration Land Data Assimilation System forcing data and different land cover scenarios. In particular, the role of surface and subsurface lateral flows is also analyzed by comparing with typical one-dimensional models. Lateral flows help to simulate soil moisture variability caused by topography at hyper-resolution (e.g., 100m), which is also essential for simulating hydrological extremes including soil moisture dryness/wetness and high/low flows. The LSM will also be coupled with a regional climate model to simulate the effect of natural and anthropogenic land cover change on regional climate, with particular focus on the land-atmosphere coupling at different resolutions with different configurations in modeling land surface hydrology.

Large Earthquakes at the Ibero-Maghrebian Region: Basis for an EEWS

NASA Astrophysics Data System (ADS)

Buforn, Elisa; Udías, Agustín; Pro, Carmen

2015-09-01

Large earthquakes (Mw > 6, Imax > VIII) occur at the Ibero-Maghrebian region, extending from a point (12ºW) southwest of Cape St. Vincent to Tunisia, with different characteristics depending on their location, which cause considerable damage and casualties. Seismic activity at this region is associated with the boundary between the lithospheric plates of Eurasia and Africa, which extends from the Azores Islands to Tunisia. The boundary at Cape St. Vincent, which has a clear oceanic nature in the westernmost part, experiences a transition from an oceanic to a continental boundary, with the interaction of the southern border of the Iberian Peninsula, the northern border of Africa, and the Alboran basin between them, corresponding to a wide area of deformation. Further to the east, the plate boundary recovers its oceanic nature following the northern coast of Algeria and Tunisia. The region has been divided into four zones with different seismic characteristics. From west to east, large earthquake occurrence, focal depth, total seismic moment tensor, and average seismic slip velocities for each zone along the region show the differences in seismic release of deformation. This must be taken into account in developing an EEWS for the region.

Cerebral edema, mass effects, and regional blood volume in man.

PubMed

Penn, R D; Kurtz, D

1977-03-01

The authors conducted quantitative analysis of computerized tomography (CT) scans to measure tumor size, cerebral edema, and regional blood volume in man. Mass lesions without edema caused a local reduction in blood volume. Cerebral edema also reduced blood volume in proportion to its severity. Consideration of the electrolyte changes and water shifts in white-matter edema suggested that the decrease in absorption coefficient seen in CT scans was due to the increase in water content. Thus, in cerebral edema separation of blood vessels as well as increased interstitial pressure decrease blood volume, and the regional differences in turn reflect pressure gradients within the brain.

Effects of Socioeconomic Status on Television Viewing Conditions of Preschoolers in Northern Greece

ERIC Educational Resources Information Center

Natsiopoulou, Triantafillia; Melissa-Halikiopoulou, Chrisoula

2009-01-01

The purpose of this study was to identify the effects of television (TV) on preschoolers, their TV viewing patterns and the conditions under which they watch TV, taking into consideration their different socioeconomic and regional backgrounds. The survey instrument was a questionnaire with 23 closed-ended questions, given to parents whose children…

Context Matters: A Critical Consideration of Latina/o Student Success Outcomes within Different Institutional Contexts

ERIC Educational Resources Information Center

Zerquera, Desiree D.; Gross, Jacob P. K.

2017-01-01

This article examined the effect of elements within Latina/o students' institutional context on Latina/o student success outcomes. Findings highlight the significant role institutional contexts play in Latina/o success. Specifically, it was found that student success was lower for students enrolled at regional campuses and campuses that serve high…

Integration of color, orientation, and size functional domains in the ventral pathway

PubMed Central

Ghose, Geoffrey M.; Ts’o, Daniel Y.

2017-01-01

Abstract. Functional specialization within the extrastriate areas of the ventral pathway associated with visual form analysis is poorly understood. Studies comparing the functional selectivities of neurons within the early visual areas have found that there are more similar than different between the areas. We simultaneously imaged visually evoked activation over regions of V2 and V4 and parametrically varied three visual attributes for which selectivity exists in both areas: color, orientation, and size. We found that color selective regions were observed in both areas and were of similar size and spatial distribution. However, two major areal distinctions were observed: V4 contained a greater number and diversity of color-specific regions than V2 and exhibited a higher degree of overlap between domains for different functional attributes. In V2, size and color regions were largely segregated from orientation domains, whereas in V4 both color and size regions overlapped considerably with orientation regions. Our results suggest that higher-order composite selectivities in the extrastriate cortex may arise organically from the interactions afforded by an overlap of functional domains for lower order selectivities. PMID:28573155

In silico segmentations of lentivirus envelope sequences

PubMed Central

Boissin-Quillon, Aurélia; Piau, Didier; Leroux, Caroline

2007-01-01

Background The gene encoding the envelope of lentiviruses exhibits a considerable plasticity, particularly the region which encodes the surface (SU) glycoprotein. Interestingly, mutations do not appear uniformly along the sequence of SU, but they are clustered in restricted areas, called variable (V) regions, which are interspersed with relatively more stable regions, called constant (C) regions. We look for specific signatures of C/V regions, using hidden Markov models constructed with SU sequences of the equine, human, small ruminant and simian lentiviruses. Results Our models yield clear and accurate delimitations of the C/V regions, when the test set and the training set were made up of sequences of the same lentivirus, but also when they were made up of sequences of different lentiviruses. Interestingly, the models predicted the different regions of lentiviruses such as the bovine and feline lentiviruses, not used in the training set. Models based on composite training sets produce accurate segmentations of sequences of all these lentiviruses. Conclusion Our results suggest that each C/V region has a specific statistical oligonucleotide composition, and that the C (respectively V) regions of one of these lentiviruses are statistically more similar to the C (respectively V) regions of the other lentiviruses, than to the V (respectively C) regions of the same lentivirus. PMID:17376229

Pathways of fish invasions in the Mid-Atlantic region of the United States

USGS Publications Warehouse

Lapointe, Nicolas W. R.; Fuller, Pam; Neilson, Matthew; Murphy, Brian R.; Angermeier, Paul

2016-01-01

Non-native fish introductions are a major threat to biodiversity and fisheries, and occur through numerous pathways that vary regionally in importance. A key strategy for managing invasions is to focus prevention efforts on pathways posing the greatest risk of future introductions. We identified high-risk pathways for fish establishment in the Mid-Atlantic region of the United States based on estimates of probability of establishment and records of previous introductions, which were considered in the context of emerging socioeconomic trends. We used estimates of propagule pressure, species’ environmental tolerance, and size of species pool to assess the risk of establishment by pathway. Pathways varied considerably in historic importance and species composition, with the majority of species introduced intentionally via stocking (primarily for sport, forage, or biocontrol) or bait release. Bait release, private stocking, illegal introductions intended to establish reproducing populations (e.g., of sport fish), aquaculture, and the sale of live organisms all create risks for future invasions in the Mid-Atlantic region. Of these pathways, bait release probably poses the greatest risk of introductions for the Mid-Atlantic region because propagule pressure is moderate, most released species are tolerant of local environmental conditions, and the pool of species available for transplantation is large. Our findings differ considerably from studies in other regions (e.g., bait release is a dominant pathway in the Mid-Atlantic region, whereas illegal introduction of sport fish is dominant in the western US and aquarium releases are dominant in Florida), demonstrating the need for regional-scale assessments of, and management strategies for, introduction pathways.

South East Asia, Differing Socioeconomic Factors, Differing Access to Radiotherapy: The Philippines, a Microcosm.

PubMed

Calaguas, Miriam Joy C; Gubat, Johannes A

2017-04-01

The accessibility of radiotherapy in Southeast Asia, a region characterized by diversity in both economy and culture, differ widely among its member countries. In most countries, access is not universal and is generally limited by radiotherapy resources and the health-seeking behavior of patients. This in turn relates to the current health policy in place, the practice of radiation oncology, and cultural factors such as religion and family dynamics. Although it is clear that radiotherapy access parallel economic development, it is also affected by different social factors that work to facilitate or impede its improvement. These factors are herein described in relation to the Philippine situation, where there is wide economic disparity, multiple subcultures, and logistical impediments to improving radiotherapy access, reminiscent of the Southeast Asian region. In the face of increasing cancer burden, it becomes increasingly important to improve services and develop new and efficient approaches taking different cultural factors into consideration. Through regional and international cooperation, solutions to the common and complex problem of inequity in radiotherapy access may be developed. Copyright © 2017. Published by Elsevier Inc.

An ethnobotanical survey of medicinal plants used in the Siwai and Buin districts of the Autonomous Region of Bougainville.

PubMed

Waruruai, Julie; Sipana, Beulah; Koch, Michael; Barrows, Louis R; Matainaho, Teatulohi K; Rai, Prem P

2011-11-18

Traditional knowledge of medicinal plant use in many regions of Papua New Guinea and the Autonomous Region of Bougainville is poorly described and rapidly disappearing. A program initiated by the University of Papua New Guinea to systematically document and preserve traditional knowledge of medicinal plant use was initiated with WHO help in 2001. To document and compare medicinal plant use in the Siwai and Buin districts of the Island of Bougainville. Siwai and Buin districts represent two adjacent geographic regions of differing language traditions. This report is a combination of two University of Papua New Guinea reports generated using a University of Papua New Guinea and Papua New Guinea Department of Health approved survey questionnaire "Information sheet on traditional herbal reparations and medicinal plants of Papua New Guinea". Although Siwai and Buin districts are adjacent in Southern Bougainville, there is considerable variation in the specific plants used medicinally and the specific uses of those plants that are used commonly in the two regions. In addition, many of the plants used in the region are widely distributed species that are used medicinally in other settings. Nevertheless, the high endemicity of plants and the extraordinary cultural diversity in the Autonomous Region of Bougainville has yielded description of the medicinal use of many plants that have not previously been reported in the wider scientific literature. Efforts to document and preserve traditional knowledge of plant use in Papua New Guinea have yielded important new records of plants with potential application in the provision of health care for a developing nation with an under developed Western style rural health care system. This report documents substantial commonality in the general modes of medicinal plant preparation and in the health care applications of plant use in the Siwai and Buin traditions, however, there was considerable difference noted in the particular uses of the specific plants used in one or another of the districts. Copyright © 2011. Published by Elsevier Ireland Ltd.

Atmospheric circulation types and extreme areal precipitation in southern central Europe

NASA Astrophysics Data System (ADS)

Jacobeit, Jucundus; Homann, Markus; Philipp, Andreas; Beck, Christoph

2017-04-01

Gridded daily rainfall data for southern central Europe are aggregated to regions of similar precipitation variability by means of S-mode principal component analyses separately for the meteorological seasons. Atmospheric circulation types (CTs) are derived by a particular clustering technique including large-scale fields of SLP, vertical wind and relative humidity at the 700 hPa level as well as the regional rainfall time series. Multiple regression models with monthly CT frequencies as predictors are derived for monthly frequencies and amounts of regional precipitation extremes (beyond the 95 % percentile). Using predictor output from different global climate models (ECHAM6, ECHAM5, EC-EARTH) for different scenarios (RCP4.5, RCP8.5, A1B) and two projection periods (2021-2050, 2071-2100) leads to assessments of future changes in regional precipitation extremes. Most distinctive changes are indicated for the summer season with mainly increasing extremes for the earlier period and widespread decreasing extremes towards the end of the 21st century, mostly for the strong scenario. Considerable uncertainties arise from the predictor use of different global climate models, especially during the winter and spring seasons.

Demersal fish assemblages on seamounts and other rugged features in the northeastern Caribbean

NASA Astrophysics Data System (ADS)

Quattrini, Andrea M.; Demopoulos, Amanda W. J.; Singer, Randal; Roa-Varon, Adela; Chaytor, Jason D.

2017-05-01

Recent investigations of demersal fish communities in deepwater (>50 m) habitats have considerably increased our knowledge of the factors that influence the assemblage structure of fishes across mesophotic to deep-sea depths. While different habitat types influence deepwater fish distribution, whether different types of rugged seafloor features provide functionally equivalent habitat for fishes is poorly understood. In the northeastern Caribbean, different types of rugged features (e.g., seamounts, banks, canyons) punctuate insular margins, and thus create a remarkable setting in which to compare demersal fish communities across various features. Concurrently, several water masses are vertically layered in the water column, creating strong stratification layers corresponding to specific abiotic conditions. In this study, we examined differences among fish assemblages across different features (e.g., seamount, canyon, bank/ridge) and water masses at depths ranging from 98 to 4060 m in the northeastern Caribbean. We conducted 26 remotely operated vehicle dives across 18 sites, identifying 156 species of which 42% of had not been previously recorded from particular depths or localities in the region. While rarefaction curves indicated fewer species at seamounts than at other features in the NE Caribbean, assemblage structure was similar among the different types of features. Thus, similar to seamount studies in other regions, seamounts in the Anegada Passage do not harbor distinct communities from other types of rugged features. Species assemblages, however, differed among depths, with zonation generally corresponding to water mass boundaries in the region. High species turnover occurred at depths <1200 m, and may be driven by changes in water mass characteristics including temperature (4.8-24.4 °C) and dissolved oxygen (2.2-9.5 mg per l). Our study suggests the importance of water masses in influencing community structure of benthic fauna, while considerably adding to the knowledge of mesophotic and deep-sea fish biogeography.

Demersal fish assemblages on seamounts and other rugged features in the northeastern Caribbean

USGS Publications Warehouse

Quattrini, Andrea M.; Demopoulos, Amanda W. J.; Singer, Randal; Roa-Varon, Adela; Chaytor, Jason D.

2017-01-01

Recent investigations of demersal fish communities in deepwater (>50 m) habitats have considerably increased our knowledge of the factors that influence the assemblage structure of fishes across mesophotic to deep-sea depths. While different habitat types influence deepwater fish distribution, whether different types of rugged seafloor features provide functionally equivalent habitat for fishes is poorly understood. In the northeastern Caribbean, different types of rugged features (e.g., seamounts, banks, canyons) punctuate insular margins, and thus create a remarkable setting in which to compare demersal fish communities across various features. Concurrently, several water masses are vertically layered in the water column, creating strong stratification layers corresponding to specific abiotic conditions. In this study, we examined differences among fish assemblages across different features (e.g., seamount, canyon, bank/ridge) and water masses at depths ranging from 98 to 4060 m in the northeastern Caribbean. We conducted 26 remotely operated vehicle dives across 18 sites, identifying 156 species of which 42% of had not been previously recorded from particular depths or localities in the region. While rarefaction curves indicated fewer species at seamounts than at other features in the NE Caribbean, assemblage structure was similar among the different types of features. Thus, similar to seamount studies in other regions, seamounts in the Anegada Passage do not harbor distinct communities from other types of rugged features. Species assemblages, however, differed among depths, with zonation generally corresponding to water mass boundaries in the region. High species turnover occurred at depths <1200 m, and may be driven by changes in water mass characteristics including temperature (4.8–24.4 °C) and dissolved oxygen (2.2–9.5 mg per l). Our study suggests the importance of water masses in influencing community structure of benthic fauna, while considerably adding to the knowledge of mesophotic and deep-sea fish biogeography.

The effect of regional politics on regional life expectancy in Italy (1980-2010).

PubMed

Jonker, Marcel F; D'Ippolito, Edoardo; Eikemo, Terje A; Congdon, Peter D; Nante, Nicola; Mackenbach, Johan P; Kamphuis, Carlijn B M

2017-03-01

The evidence on the association between politics and health is scarce considering the importance of this topic for population health. Studies that investigated the effect of different political regimes on health outcomes show inconsistent results. Bayesian time-series cross-section analyses are used to examine the overall impact of regional politics on variations in Italian regional life expectancy (LE) at birth during the period 1980-2010. Our analyses control for trends in and unobserved determinants of regional LE, correct for temporal as well as spatial autocorrelation, and employ a flexible specification for the timing of the political effects. In the period from 1980 to 1995, we find no evidence that the communist, left-oriented coalitions and Christian Democratic, centre-oriented coalitions have had an effect on regional LE. In the period from 1995 onwards, after a major reconfiguration of Italy's political regimes and a major healthcare reform, we again find no evidence that the Centre-Left and Centre-Right coalitions have had a significant impact on regional LE. The presented results provide no support for the notion that different regional political regimes in Italy have had a differential effect on regional LE, even though Italian regions have had considerable and increasing autonomy over healthcare and health-related policies and expenditures.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Corley, Richard A; Minard, Kevin R; Kabilan, Senthil

The percentages of total airflows over the nasal respiratory and olfactory epithelium of female rabbits were calculated from computational fluid dynamics (CFD) simulations of steady-state inhalation. These airflows calculations, along with nasal airway geometry determinations, are critical parameters for hybrid CFD/physiologically based pharmacokinetic models that describe the nasal dosimetry of water-soluble or reactive gases and vapors in rabbits. CFD simulations were based upon three-dimensional computational meshes derived from magnetic resonance images of three adult female New Zealand White (NZW) rabbits. In the anterior portion of the nose, the maxillary turbinates of rabbits are considerably more complex than comparable regions inmore » rats, mice, monkeys, or humans. This leads to a greater surface area to volume ratio in this region and thus the potential for increased extraction of water soluble or reactive gases and vapors in the anterior portion of the nose compared to many other species. Although there was considerable interanimal variability in the fine structures of the nasal turbinates and airflows in the anterior portions of the nose, there was remarkable consistency between rabbits in the percentage of total inspired airflows that reached the ethmoid turbinate region (~50%) that is presumably lined with olfactory epithelium. These latter results (airflows reaching the ethmoid turbinate region) were higher than previous published estimates for the male F344 rat (19%) and human (7%). These differences in regional airflows can have significant implications in interspecies extrapolations of nasal dosimetry.« less

Wildland fire emissions, carbon, and climate: U.S. emissions inventories

Treesearch

Narasimhan K. Larkin; Sean M. Raffuse; Tara M. Strand

2014-01-01

Emissions from wildland fire are both highly variable and highly uncertain over a wide range of temporal and spatial scales. Wildland fire emissions change considerably due to fluctuations from year to year with overall fire season severity, from season to season as different regions pass in and out of wildfire and prescribed fire periods, and from day to day as...

Rural Youth in the USA: Status, Needs, and Suggestions for Development.

ERIC Educational Resources Information Center

Kuvlesky, William P.

Studies on U.S. rural youth indicate current regional and ethnic diversity; limited rural-urban differences; and some limited social change in terms of values, needs, and aspirations. The size of the rural youth population is considerable (25,013,948 out of a total youth population of 93,313,518 in 1970). The majority of rural youth are white…

State Budgeting for Higher Education: Trends in State Revenue Appropriations from 1968 to 1977.

ERIC Educational Resources Information Center

Ruyle, Janet H.; Glenny, Lyman A.

Results of a ten-year review of state appropriations for higher education in the states are presented. Findings reveal a wide range of differences among the regions of the nation and among the individual states. The share of education appropriations received by higher education institutions has grown considerably, with the greatest rate of growth…

How Important Is Private Higher Education in Europe? A Regional Analysis in Global Context

ERIC Educational Resources Information Center

Levy, Daniel C.

2012-01-01

The importance of private higher education (PHE) is increasingly clear globally. But does Europe fit the global generalisation? This question can be assessed with reference to two major considerations: the size of PHE and the degree of private-public difference. The growth of PHE in Europe has been delayed and limited compared to that in most of…

Emotional and Behavioural Difficulties among Middle School Students in Oman: An Examination of Prevalence Rate and Gender Differences

ERIC Educational Resources Information Center

Emam, Mahmoud Mohamed; Kazem, Ali Mahdi; Al-Zubaidy, Abdulqawi Salim

2016-01-01

Children with emotional and behavioural difficulties (EBDs) began to receive considerable attention in several countries in the Middle East and North Africa region including Oman. In the Omani context, there is lack of valid assessment instruments which can be used to obtain information on EBDs in schools. The current study used the Arabic…

Abnormality in face scanning by children with autism spectrum disorder is limited to the eye region: Evidence from multi-method analyses of eye tracking data

PubMed Central

Yi, Li; Fan, Yuebo; Quinn, Paul C.; Feng, Cong; Huang, Dan; Li, Jiao; Mao, Guoquan; Lee, Kang

2012-01-01

There has been considerable controversy regarding whether children with autism spectrum disorder (ASD) and typically developing children (TD) show different eye movement patterns when processing faces. We investigated ASD and age- and IQ-matched TD children's scanning of faces using a novel multi-method approach. We found that ASD children spent less time looking at the whole face generally. After controlling for this difference, ASD children's fixations of the other face parts, except for the eye region, and their scanning paths between face parts were comparable either to the age-matched or IQ-matched TD groups. In contrast, in the eye region, ASD children's scanning differed significantly from that of both TD groups: (a) ASD children fixated significantly less on the right eye (from the observer's view); (b) ASD children's fixations were more biased towards the left eye region; and (c) ASD children fixated below the left eye, whereas TD children fixated on the pupil region of the eye. Thus, ASD children do not have a general abnormality in face scanning. Rather, their abnormality is limited to the eye region, likely due to their strong tendency to avoid eye contact. PMID:23929830

Characteristics of Superjunction Lateral-Double-Diffusion Metal Oxide Semiconductor Field Effect Transistor and Degradation after Electrical Stress

NASA Astrophysics Data System (ADS)

Lin, Jyh‑Ling; Lin, Ming‑Jang; Lin, Li‑Jheng

2006-04-01

The superjunction lateral double diffusion metal oxide semiconductor field effect has recently received considerable attention. Introducing heavily doped p-type strips to the n-type drift region increases the horizontal depletion capability. Consequently, the doping concentration of the drift region is higher and the conduction resistance is lower than those of conventional lateral-double-diffusion metal oxide semiconductor field effect transistors (LDMOSFETs). These characteristics may increase breakdown voltage (\\mathit{BV}) and reduce specific on-resistance (Ron,sp). In this study, we focus on the electrical characteristics of conventional LDMOSFETs on silicon bulk, silicon-on-insulator (SOI) LDMOSFETs and superjunction LDMOSFETs after bias stress. Additionally, the \\mathit{BV} and Ron,sp of superjunction LDMOSFETs with different N/P drift region widths and different dosages are discussed. Simulation tools, including two-dimensional (2-D) TSPREM-4/MEDICI and three-dimensional (3-D) DAVINCI, were employed to determine the device characteristics.

High time-resolved radon progeny measurements in the Arctic region (Svalbard islands, Norway): results and potentialities

NASA Astrophysics Data System (ADS)

Salzano, Roberto; Pasini, Antonello; Ianniello, Antonietta; Mazzola, Mauro; Traversi, Rita; Udisti, Roberto

2018-05-01

The estimation of radon progeny in the Arctic region represents a scientific challenge due to the required low limit of detection in consideration of the limited radon emanation associated with permafrost dynamics. This preliminary study highlighted, for the first time above 70° N, the possibility to monitor radon progeny in the Arctic region with a higher time resolution. The composition of the radon progeny offered the opportunity to identify air masses dominated by long-range transport, in presence or absence of near-constant radon progeny instead of long- and short-lived progenies. Furthermore, the different ratio between radon and thoron progenies evidenced the contributions of local emissions and atmospheric stability. Two different emanation periods were defined in accordance with the permafrost dynamics at the ground and several accumulation windows were recognized coherently to the meteo-climatic conditions occurring at the study site.

An inexact multistage fuzzy-stochastic programming for regional electric power system management constrained by environmental quality.

PubMed

Fu, Zhenghui; Wang, Han; Lu, Wentao; Guo, Huaicheng; Li, Wei

2017-12-01

Electric power system involves different fields and disciplines which addressed the economic system, energy system, and environment system. Inner uncertainty of this compound system would be an inevitable problem. Therefore, an inexact multistage fuzzy-stochastic programming (IMFSP) was developed for regional electric power system management constrained by environmental quality. A model which concluded interval-parameter programming, multistage stochastic programming, and fuzzy probability distribution was built to reflect the uncertain information and dynamic variation in the case study, and the scenarios under different credibility degrees were considered. For all scenarios under consideration, corrective actions were allowed to be taken dynamically in accordance with the pre-regulated policies and the uncertainties in reality. The results suggest that the methodology is applicable to handle the uncertainty of regional electric power management systems and help the decision makers to establish an effective development plan.

Sgr A* as Source of the Positrons Observed in the Galactic Center Region

NASA Astrophysics Data System (ADS)

Jean, Pierre; Guessoum, Nidhal; Ferrière, Katia

2017-01-01

We explore the possibility that a substantial fraction of the positrons observed to annihilate in the central region of our Galaxy come from the supermassive black hole Sgr A* that lies at the center. This idea was proposed by several authors, but the propagation of the emitted positrons into the bulge and beyond remained a serious problem for models of the origin of GC positrons. We assume models of positron production with different energies. The propagation of positrons from their production site is followed in detail with Monte-Carlo simulations, taking into account the physical conditions of the propagation regions as well as various physical interactions. Using the known physics of positron annihilation in astrophysical environments, we calculate the properties of the annihilation emission (time evolution and spatial distribution) for the different models under consideration. We present the results of these simulations and the conclusions/constraints that can be inferred from them.

Epidemiology and economic burden of measles, mumps, pertussis, and varicella in Germany: a systematic review.

PubMed

Damm, Oliver; Witte, Julian; Wetzka, Stefanie; Prosser, Christine; Braun, Sebastian; Welte, Robert; Greiner, Wolfgang

2016-09-01

Despite the availability of vaccines and the existence of public vaccination recommendations, outbreaks of vaccine-preventable childhood diseases still cause public health debate. The objective of this systematic review was to provide an overview of the current epidemiology and economic burden of measles, mumps, pertussis, and varicella in Germany. We systematically reviewed studies published since 2000. The literature search was conducted using PubMed and EMBASE. Also, we used German notification data to give an up-to-date overview of the epidemiology of the four diseases under consideration. Thirty-six studies were included in our review. Results suggest that there is still considerable morbidity due to childhood diseases in Germany. Studies providing cost estimates are scarce. Comparative analyses of different data sources (notification data vs. claims data) revealed a potential underestimation of incidence estimates when using notification data. Furthermore, several studies showed regional differences in incidence of some of the diseases under consideration. Our findings underline the need for improved vaccination and communication strategies targeting all susceptible age and risk groups on a national and local level.

[Variations among Spanish regions in the use of three cardiovascular technologies].

PubMed

Fitch-Warner, Kathryn; García de Yébenes, María J; Lázaro y de Mercado, Pablo; Belaza-Santurde, Javier

2006-12-01

There is evidence that some geographic variations in the use of medical technologies are not explained by differences in disease burden. The objectives of this study were to quantify variability in the use of percutaneous coronary intervention (PCI), implantable cardioverter-defibrillators (ICDs), and cardiac resynchronization therapy (CRT) in Spanish autonomous regions and to try to explain the variability found for the first two technologies. Linear regression models were developed in which the number of procedures performed per million population (pmp) in 2003 in each autonomous region was the dependent variable. Independent variables used included indices of technology provision, regional wealth, and disease burden. For PCI, the mean utilization rate for the whole of Spain was 1038 procedures pmp, with a high-low ratio of 1.95. Differences in gross domestic product explained 21% of the variability, but there was no relationship between the number of procedures performed and disease burden. For ICDs, the mean number of procedures performed in the whole of Spain was 46 pmp, with a high-low ratio of 3.04. As for PCI, differences in regional wealth explained 40% of the variability, with disease burden making no contribution. For CRT, the mean number of procedures performed in Spain in 2003 was 15 pmp, with a high-low ratio of 15.7. The considerable regional variation that exists in the use of these three medical technologies is principally explained by differences in regional wealth and not in disease burden.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bhattacherjee, Biplob; Mukhopadhyay, Satyanarayan; Nojiri, Mihoko M.

Here, we study the impact of including quark- and gluon-initiated jet discrimination in the search for strongly interacting supersymmetric particles at the LHC. Taking the example of gluino pair production, considerable improvement is observed in the LHC search reach on including the jet substructure observables to the standard kinematic variables within a multivariate analysis. In particular, quark and gluon jet separation has higher impact in the region of intermediate mass-gap between the gluino and the lightest neutralino, as the difference between the signal and the standard model background kinematic distributions is reduced in this region. We also compare the predictionsmore » from different Monte Carlo event generators to estimate the uncertainty originating from the modelling of the parton shower and hadronization processes.« less

Analysis of source/drain engineered 22nm FDSOI using high-k spacers

NASA Astrophysics Data System (ADS)

Malviya, Abhishek Kumar; Chauhan, R. K.

2018-04-01

While looking at the current classical scaling of devices there are lots of short channel effects come into consideration. In this paper, a novel device structure is proposed that is an improved structure of Modified Source(MS) FDSOI in terms of better electrical performance, on current and reduced off state leakage current with a higher Ion/Ioff ratio that helps in fast switching of low power nano electronic devices. Proposed structure has Modified drain and source regions with two different type to doping profile at 22nm gate length. In the upper part of engineered region (MD and MS) the doping concentration is kept high and less in the lower region. The purpose was to achieve low parasitic capacitance in source and drain region by reducing doping concentration [1].

Two-Dimensional Modeling of Heat and Moisture Dynamics in Swedish Roads: Model Set up and Parameter Sensitivity

NASA Astrophysics Data System (ADS)

Rasul, H.; Wu, M.; Olofsson, B.

2017-12-01

Modelling moisture and heat changes in road layers is very important to understand road hydrology and for better construction and maintenance of roads in a sustainable manner. In cold regions due to the freezing/thawing process in the partially saturated material of roads, the modeling task will become more complicated than simple model of flow through porous media without freezing/thawing pores considerations. This study is presenting a 2-D model simulation for a section of highway with considering freezing/thawing and vapor changes. Partial deferential equations (PDEs) are used in formulation of the model. Parameters are optimized from modelling results based on the measured data from test station on E18 highway near Stockholm. Impacts of phase change considerations in the modelling are assessed by comparing the modeled soil moisture with TDR-measured data. The results show that the model can be used for prediction of water and ice content in different layers of the road and at different seasons. Parameter sensitivities are analyzed by implementing a calibration strategy. In addition, the phase change consideration is evaluated in the modeling process, by comparing the PDE model with another model without considerations of freezing/thawing in roads. The PDE model shows high potential in understanding the moisture dynamics in the road system.

Understanding levels of morbidity and hospitalization in Kerala, India.

PubMed Central

Dilip, T. R.

2002-01-01

The prevalence of ailments and hospitalization in Kerala was examined using data from the 52 nd National Sample Survey Data on Health Care in Kerala in 1995-6. The survey included 24401 people from 4928 households. Age and seasonality had considerable effects on the morbidity of individuals. The burden of ill health was higher in rural areas than in urban areas. People who were more likely to have a better lifestyle had a higher level of morbidity and hospitalization. Regional differences were seen, with levels of morbidity and hospitalization higher in the comparatively developed regions of Southern Kerala than in Northern Kerala. Factors like physical accessibility of health care services and capacity to seek health care services could create artificial differences in morbidity and hospitalization among different subgroups of the population in Kerala. PMID:12378294

Anthropogenic activities and coastal environmental quality: a regional quantitative analysis in southeast China with management implications.

PubMed

Chen, Kai; Liu, Yan; Huang, Dongren; Ke, Hongwei; Chen, Huorong; Zhang, Songbin; Yang, Shengyun; Cai, Minggang

2018-02-01

Regional analysis of environmental issues has always been a hot topic in the field of sustainable development. Because the different levels of economic growth, urbanization, resource endowments, etc. in different regions generate apparently different ecological responses, a better description and comparison across different regions will provide more valuable implications for ecological improvement and policymaking. In this study, seven typical bays in southeast China that are a rapid developing area were selected to quantitatively analyze the relationship between socioeconomic development and coastal environmental quality. Based on the water quality data from 2007 to 2015, the multivariate statistical method was applied to analyze the potential environmental risks and to classify the seven bays based on their environmental quality status. The possible variation trends of environmental indices were predicted based on the cross-regional panel data by Environmental Kuznets Curve. The results showed that there were significant regional differences among the seven bays, especially Quanzhou, Xiamen, and Luoyuan Bays, suffered from severer artificial disturbances than other bays, despite their different development patterns. Socioeconomic development level was significantly associated with some water quality indices (pH, DIN, PO 4 -P); the association was roughly positive: the areas with higher GDP per capita have some worse water quality indices. In addition, the decreasing trend of pH values and the increasing trend of nutrient concentration in the seven bays will continue in the foreseeable future. In consideration of the variation trends, the limiting nutrient strategy should be implemented to mitigate the deterioration of the coastal environments.

Sex, race, and consideration of bariatric surgery among primary care patients with moderate to severe obesity.

PubMed

Wee, Christina C; Huskey, Karen W; Bolcic-Jankovic, Dragana; Colten, Mary Ellen; Davis, Roger B; Hamel, Marybeth

2014-01-01

Bariatric surgery is one of few obesity treatments to produce substantial weight loss but only a small proportion of medically-eligible patients, especially men and racial minorities, undergo bariatric surgery. To describe primary care patients' consideration of bariatric surgery, potential variation by sex and race, and factors that underlie any variation. Telephone interview of 337 patients with a body mass index or BMI > 35 kg/m(2) seen at four diverse primary care practices in Greater-Boston. Patients' consideration of bariatric surgery. Of 325 patients who had heard of bariatric surgery, 34 % had seriously considered surgery. Men were less likely than women and African Americans were less likely than Caucasian patients to have considered surgery after adjustment for sociodemographics and BMI. Comorbid conditions did not explain sex and racial differences but racial differences dissipated after adjustment for quality of life (QOL), which tended to be higher among African American than Caucasian patients. Physician recommendation of bariatric surgery was independently associated with serious consideration for surgery [OR 4.95 (95 % CI 2.81-8.70)], but did not explain variation in consideration of surgery across sex and race. However, if recommended by their doctor, men were as willing and African American and Hispanic patients were more willing to consider bariatric surgery than their respective counterparts after adjustment. Nevertheless, only 20 % of patients reported being recommended bariatric surgery by their doctor and African Americans and men were less likely to receive this recommendation; racial differences in being recommended surgery were also largely explained by differences in QOL. High perceived risk to bariatric surgery was the most commonly cited barrier; financial concerns were uncommonly cited. Single geographic region; examined consideration and not who eventually proceeded with bariatric surgery. African Americans and men were less likely to have considered bariatric surgery and were less likely to have been recommended surgery by their doctors. Differences in how obesity affects QOL appear to account for some of these variations. High perceived risk rather than financial barrier was the major deterrent for patients.

Interdependence of peat and vegetation in a tropical peat swamp forest.

PubMed Central

Page, S E; Rieley, J O; Shotyk, W; Weiss, D

1999-01-01

The visual uniformity of tropical peat swamp forest masks the considerable variation in forest structure that has evolved in response to differences and changes in peat characteristics over many millennia. Details are presented of forest structure and tree composition of the principal peat swamp forest types in the upper catchment of Sungai Sebangau, Central Kalimantan, Indonesia, in relation to thickness and hydrology of the peat. Consideration is given to data on peat geochemistry and age of peat that provide evidence of the ombrotrophic nature of this vast peatland and its mode of formation. The future sustainability of this ecosystem is predicted from information available on climate change and human impact in this region. PMID:11605630

A Comparative GLOBE Study: Regional Differences in Cultural Values, Cultural Practices and Perspectives of Leadership between Research Administrators in the United States, Europe and Australasia

ERIC Educational Resources Information Center

Sablatura, Martha Trevino

2012-01-01

The (GLOBE) Global Leadership and Organizational Behavior Effectiveness Study (House, Gupta, Hanges, Javidan, and Dorfman, 2004), introduced the concept of leadership across cultures and, along with other empirical research, has shown that the status and influence of leadership vary considerably as a result of the cultural forces in different…

Jet-impingement heat transfer in gas turbine systems.

PubMed

Han, B; Goldstein, R J

2001-05-01

A review of jet-impingement heat transfer in gas turbine systems is presented. Characteristics of the different flow regions for submerged jets--free jet, stagnation flow, and wall jet--are reviewed. Heat transfer characteristics of both single and multiple jets are discussed with consideration of the effects of important parameters relevant to gas turbine systems including curvature of surfaces, crossflow, angle of impact, and rotation.

Analysis of the balancing of the wind and solar energy resources in Andalusia (Southern Spain)

NASA Astrophysics Data System (ADS)

Santos-Alamillos, F. J.; Pozo-Vazquez, D.; Lara-Fanego, V.; Ruiz-Arias, J. A.; Hernandez-Alvaro, J.; Tova-Pescador, J.

2010-09-01

A higher penetration of the renewable energy in the electric system in the future will be conditioned to a reduction of the uncertainty of the yield. A way to obtain this goal is to analyze the balancing between the productions of different sources of renewable energy, trying to combine these productions. In this work we analyze, from a meteorological point of view, the balancing between wind and solar energy resources in Andalusia (southern Iberian Peninsula). To this end, wind speed and global radiation data corresponding to an one year integration of the Weather Research and Forecasting (WRF) Numerical Weather Prediction (NWP) model were analyzed. Two method of analysis were used: a point correlation analysis and a Canonical Correlation Analysis (CCA). Results from these analyses allow obtaining, eventually, areas of local and distributed balancing between the wind and solar energy resources. The analysis was carried out separately for the different seasons of the year. Results showed, overall, a considerable balancing effect between the wind and solar resources in the mountain areas of the interior of the region, along the coast of the central part of the region and, specially, in the coastal area near the Gibraltar strait. Nevertheless, considerable differences were found between the seasons of the year, which may lead to compensating effects. Autumn proved to be the season with the most significant results.

Individual Differences in the Alignment of Structural and Functional Markers of the V5/MT Complex in Primates

PubMed Central

Large, I.; Bridge, H.; Ahmed, B.; Clare, S.; Kolasinski, J.; Lam, W. W.; Miller, K. L.; Dyrby, T. B.; Parker, A. J.; Smith, J. E. T.; Daubney, G.; Sallet, J.; Bell, A. H.; Krug, K.

2016-01-01

Extrastriate visual area V5/MT in primates is defined both structurally by myeloarchitecture and functionally by distinct responses to visual motion. Myelination is directly identifiable from postmortem histology but also indirectly by image contrast with structural magnetic resonance imaging (sMRI). First, we compared the identification of V5/MT using both sMRI and histology in Rhesus macaques. A section-by-section comparison of histological slices with in vivo and postmortem sMRI for the same block of cortical tissue showed precise correspondence in localizing heavy myelination for V5/MT and neighboring MST. Thus, sMRI in macaques accurately locates histologically defined myelin within areas known to be motion selective. Second, we investigated the functionally homologous human motion complex (hMT+) using high-resolution in vivo imaging. Humans showed considerable intersubject variability in hMT+ location, when defined with myelin-weighted sMRI signals to reveal structure. When comparing sMRI markers to functional MRI in response to moving stimuli, a region of high myelin signal was generally located within the hMT+ complex. However, there were considerable differences in the alignment of structural and functional markers between individuals. Our results suggest that variation in area identification for hMT+ based on structural and functional markers reflects individual differences in human regional brain architecture. PMID:27371764

Effects of particle migration on the features of their transport by tidal currents in a region of freshwater influence

NASA Astrophysics Data System (ADS)

Korotenko, K. A.; Sentchev, A. V.

2008-10-01

Using a combined model that couples a three-dimensional ocean circulation model, a model for tidal currents, and a model for particle transport, the structure of the velocity field of the tidal current and the transport of particles migrating over the vertical were studied in the zone of the influence of the riverine runoff in the eastern part of the English Channel. It was found that the interaction between the tidal current and the baroclinic flow formed by the riverine runoff off the northeastern coast of France generates a steady-state intensive (˜0.3 m/s) residual current in the zone of the effect of the riverine runoff. In order to assess the influence of different types of particle migration (which simulate ichthyoplankton) on the processes of their transport in the region under consideration, we performed numerical experiments with particle clusters, for which parameterization of their migration was implemented on the basis of the field observations over the proper vertical movements of different types of ichthyoplankton. The experiments showed that the distribution of the fields of the particle concentrations and the velocities of their movements depend not only on the background hydrophysical conditions but also on the character of the vertical migration of the particles. In this paper, a comparison between the results of the modeling and those of the field observations in the region under consideration are presented.

Mapping telemedicine efforts: surveying regional initiatives in Denmark.

PubMed

Kierkegaard, Patrick

2015-05-01

The aim of this study is to survey telemedicine services currently in operation across Denmark. The study specifically seeks to answer the following questions: What initiatives are deployed within the different regions? What are the motivations behind the projects? What technologies are being utilized? What medical disciplines are being supported using telemedicine systems? All data were surveyed from the Telemedicinsk Landkort, a newly created database designed to provide a comprehensive and systematic overview of all telemedicine technologies in Denmark. The results of this study suggest that a growing numbers of telemedicine initiatives are currently in operation across Denmark but that considerable variations exist in terms of regional efforts as the number of operational telemedicine projects varied from region to region. The results of this study provide a timely picture of the factors that are shaping the telemedicine landscape of Denmark and suggest potential strategies to help policymakers increase and improve national telemedicine deployment.

Transgenes in Mexican maize: molecular evidence and methodological considerations for GMO detection in landrace populations

PubMed Central

PIÑEYRO-NELSON, A; VAN HEERWAARDEN, J; PERALES, H R; SERRATOS-HERNÁNDEZ, J A; RANGEL, A; HUFFORD, M B; GEPTS, P; GARAY-ARROYO, A; RIVERA-BUSTAMANTE, R; ÁLVAREZ-BUYLLA, E R

2009-01-01

A possible consequence of planting genetically modified organisms (GMOs) in centres of crop origin is unintended gene flow into traditional landraces. In 2001, a study reported the presence of the transgenic 35S promoter in maize landraces sampled in 2000 from the Sierra Juarez of Oaxaca, Mexico. Analysis of a large sample taken from the same region in 2003 and 2004 could not confirm the existence of transgenes, thereby casting doubt on the earlier results. These two studies were based on different sampling and analytical procedures and are thus hard to compare. Here, we present new molecular data for this region that confirm the presence of transgenes in three of 23 localities sampled in 2001. Transgene sequences were not detected in samples taken in 2002 from nine localities, while directed samples taken in 2004 from two of the positive 2001 localities were again found to contain transgenic sequences. These findings suggest the persistence or re-introduction of transgenes up until 2004 in this area. We address variability in recombinant sequence detection by analyzing the consistency of current molecular assays. We also present theoretical results on the limitations of estimating the probability of transgene detection in samples taken from landraces. The inclusion of a limited number of female gametes and, more importantly, aggregated transgene distributions may significantly lower detection probabilities. Our analytical and sampling considerations help explain discrepancies among different detection efforts, including the one presented here, and provide considerations for the establishment of monitoring protocols to detect the presence of transgenes among structured populations of landraces. PMID:19143938

Transgenes in Mexican maize: molecular evidence and methodological considerations for GMO detection in landrace populations.

PubMed

Piñeyro-Nelson, A; Van Heerwaarden, J; Perales, H R; Serratos-Hernández, J A; Rangel, A; Hufford, M B; Gepts, P; Garay-Arroyo, A; Rivera-Bustamante, R; Alvarez-Buylla, E R

2009-02-01

A possible consequence of planting genetically modified organisms (GMOs) in centres of crop origin is unintended gene flow into traditional landraces. In 2001, a study reported the presence of the transgenic 35S promoter in maize landraces sampled in 2000 from the Sierra Juarez of Oaxaca, Mexico. Analysis of a large sample taken from the same region in 2003 and 2004 could not confirm the existence of transgenes, thereby casting doubt on the earlier results. These two studies were based on different sampling and analytical procedures and are thus hard to compare. Here, we present new molecular data for this region that confirm the presence of transgenes in three of 23 localities sampled in 2001. Transgene sequences were not detected in samples taken in 2002 from nine localities, while directed samples taken in 2004 from two of the positive 2001 localities were again found to contain transgenic sequences. These findings suggest the persistence or re-introduction of transgenes up until 2004 in this area. We address variability in recombinant sequence detection by analyzing the consistency of current molecular assays. We also present theoretical results on the limitations of estimating the probability of transgene detection in samples taken from landraces. The inclusion of a limited number of female gametes and, more importantly, aggregated transgene distributions may significantly lower detection probabilities. Our analytical and sampling considerations help explain discrepancies among different detection efforts, including the one presented here, and provide considerations for the establishment of monitoring protocols to detect the presence of transgenes among structured populations of landraces.

Influence of implant location on the clinical outcomes of implant abutments: a systematic review and meta-analysis

PubMed Central

ElHoussiney, Amr G; Zhang, He; Song, Jinlin; Ji, Ping; Wang, Lu; Yang, Sheng

2018-01-01

Purpose To compare the failure events and incidence of complications of different abutment materials in anterior and posterior regions. Failure was defined as complete loss of the abutment requiring replacement by a new abutment. Materials and methods Electronic searches using PubMed/Medline and Google Scholar complemented with manual searches were performed with specific search terms. Searches were restricted to publications in English between January 2006 and March 2016. Results A total of 863 and 1,264 implants were inserted in the anterior and posterior regions, respectively, in a total of 1,529 patients. No titanium abutments failed in anterior or posterior regions. On the other hand, 1.6% of zirconia abutments failed in the anterior region and 1.5% failed in the posterior region. Technical complications occurred mostly in the posterior region and mostly involved zirconia abutment. Meta-analysis was possible only for zirconia-abutment failure, due to considerable heterogeneity of studies and outcome variables. No significant difference in failure rate was found between anterior and posterior zirconia abutments (risk ratio 1.53, 95% CI 0.49–4.77; P=0.47). Conclusion This systematic review and meta-analysis showed similar outcomes of different abutment materials when used in anterior and posterior regions in terms of failure events and biological and aesthetic complications. The only significant finding was the increased incidence of technical complications in the posterior region, mostly involving zirconia abutments. Abutment-screw loosening was the most common technical complication. PMID:29520162

Age-related differences in brain activity in the subsequent memory paradigm: a meta-analysis.

PubMed

Maillet, David; Rajah, M Natasha

2014-09-01

Healthy aging is associated with declines in episodic memory. This reduction is thought to be due in part to age-related differences in encoding-related processes. In the current study, we performed an activation likelihood estimation meta-analysis of functional magnetic resonance imaging (fMRI) studies assessing age-related differences in the neural correlates of episodic encoding. Only studies using the subsequent memory paradigm were included. We found age-related under-recruitment of occipital and fusiform cortex, but over-recruitment in a set of regions including bilateral middle/superior frontal gyri, anterior medial frontal gyrus, precuneus and left inferior parietal lobe. We demonstrate that all of the regions consistently over-recruited by older adults during successful encoding exhibit either direct overlap, or occur in close vicinity to regions consistently involved in unsuccessful encoding in young adults. We discuss the possibility that this overall pattern of age-related differences represents an age-related shift in focus: away from perceptual details, and toward evaluative and personal thoughts and feelings during memory tasks. We discuss whether these age-related differences in brain activation benefit performance in older adults, and additional considerations. Copyright © 2014 Elsevier Ltd. All rights reserved.

Practical issues and lessons learned from multi-regional clinical trials via case examples: a Japanese perspective.

PubMed

Ando, Yuki; Hamasaki, Toshimitsu

2010-01-01

The multi-regional clinical trials (MRCTs) being administered in different regions of the world now play a major role in providing evidence for the efficacy and safety of new drugs amidst the simultaneous global development and worldwide registration of such drugs, in support of the expeditious availability of medical products to patients. However, such trials present considerable challenges as far as quality, design, implementation, analysis, and interpretation are concerned. In this article, we share our observations and lessons learned from the design, implementation, analysis, and interpretation of some MRCTs with case examples. Current Japanese regulatory guidance on MRCTs is introduced along with some suggestions for design, implementation, and interpretation. Copyright © 2010 John Wiley & Sons, Ltd.

Magnetic resonance imaging and computational fluid dynamics (CFD) simulations of rabbit nasal airflows for the development of hybrid CFD/PBPK models.

PubMed

Corley, R A; Minard, K R; Kabilan, S; Einstein, D R; Kuprat, A P; Harkema, J R; Kimbell, J S; Gargas, M L; Kinzell, John H

2009-05-01

The percentages of total airflows over the nasal respiratory and olfactory epithelium of female rabbits were calculated from computational fluid dynamics (CFD) simulations of steady-state inhalation. These airflow calculations, along with nasal airway geometry determinations, are critical parameters for hybrid CFD/physiologically based pharmacokinetic models that describe the nasal dosimetry of water-soluble or reactive gases and vapors in rabbits. CFD simulations were based upon three-dimensional computational meshes derived from magnetic resonance images of three adult female New Zealand White (NZW) rabbits. In the anterior portion of the nose, the maxillary turbinates of rabbits are considerably more complex than comparable regions in rats, mice, monkeys, or humans. This leads to a greater surface area to volume ratio in this region and thus the potential for increased extraction of water soluble or reactive gases and vapors in the anterior portion of the nose compared to many other species. Although there was considerable interanimal variability in the fine structures of the nasal turbinates and airflows in the anterior portions of the nose, there was remarkable consistency between rabbits in the percentage of total inspired airflows that reached the ethmoid turbinate region (approximately 50%) that is presumably lined with olfactory epithelium. These latter results (airflows reaching the ethmoid turbinate region) were higher than previous published estimates for the male F344 rat (19%) and human (7%). These differences in regional airflows can have significant implications in interspecies extrapolations of nasal dosimetry.

HCMM energy budget data as a model input for assessing regions of high potential groundwater pollution

NASA Technical Reports Server (NTRS)

Moore, D. G. (Principal Investigator); Heilman, J.; Tunheim, J. A.; Baumberger, V.

1978-01-01

The author has identified the following significant results. To investigate the general relationship between surface temperature and soil moisture profiles, a series of model calculations were carried out. Soil temperature profiles were calculated during a complete diurnal cycle for a variety of moisture profiles. Preliminary results indicate the surface temperature difference between two sites measured at about 1400 hours is related to the difference in soil moisture within the diurnal damping depth (about 50 cm). The model shows this temperature difference to vary considerably throughout the diurnal cycle.

Genomic regions in crop–wild hybrids of lettuce are affected differently in different environments: implications for crop breeding

PubMed Central

Hartman, Yorike; Hooftman, Danny A P; Uwimana, Brigitte; van de Wiel, Clemens C M; Smulders, Marinus J M; Visser, Richard G F; van Tienderen, Peter H

2012-01-01

Many crops contain domestication genes that are generally considered to lower fitness of crop–wild hybrids in the wild environment. Transgenes placed in close linkage with such genes would be less likely to spread into a wild population. Therefore, for environmental risk assessment of GM crops, it is important to know whether genomic regions with such genes exist, and how they affect fitness. We performed quantitative trait loci (QTL) analyses on fitness(-related) traits in two different field environments employing recombinant inbred lines from a cross between cultivated Lactuca sativa and its wild relative Lactuca serriola. We identified a region on linkage group 5 where the crop allele consistently conferred a selective advantage (increasing fitness to 212% and 214%), whereas on linkage group 7, a region conferred a selective disadvantage (reducing fitness to 26% and 5%), mainly through delaying flowering. The probability for a putative transgene spreading would therefore depend strongly on the insertion location. Comparison of these field results with greenhouse data from a previous study using the same lines showed considerable differences in QTL patterns. This indicates that care should be taken when extrapolating experiments from the greenhouse, and that the impact of domestication genes has to be assessed under field conditions. PMID:23028403

Does the Functional Form of the Association Between Education and Mortality Differ by U.S. Region?

PubMed

Sheehan, Connor; Montez, Jennifer Karas; Sasson, Isaac

2018-01-01

To understand the education-mortality association among U.S. adults, recent studies have documented its national functional form. However, the functional form of education-mortality relationship may vary across geographic contexts. The four U.S. Census regions differ considerably in their social and economic policies, employment opportunities, income levels, and other factors that may affect how education lowers the risk of mortality. Thus, we documented regional differences in the functional form of the education-mortality association and examined the role of employment and income in accounting for regional differences. We used data on non-Hispanic white adults (2,981,672, person years) aged 45-84 in the 2000-2009 National Health Interview Survey, with Linked Mortality File through 2011 (37,598 deaths) and estimated discrete-time hazard models. The functional form of education and adult mortality was best characterized by credentialism in the Midwest, Northeast, and for Western men. For Western women, the association was linear, consistent with the human capital model. In the South, we observed a combination of mechanisms, with mortality risk declining with each year of schooling and a step change with high school graduation, followed by steeper decline thereafter. Our work adds to the increasing body of research that stresses the importance of contexts in shaping the education-mortality relationship.

Changes in regional heatwave characteristics as a function of increasing global temperature.

PubMed

Perkins-Kirkpatrick, S E; Gibson, P B

2017-09-25

The Paris Agreement calls for global warming to be limited to 1.5-2 °C. For the first time, this study investigates how different regional heatwave characteristics (intensity, frequency and duration) are projected to change relative to increasing global warming thresholds. Increases in heatwave days between 4-34 extra days per season are projected per °C of global warming. Some tropical regions could experience up to 120 extra heatwave days/season if 5 °C is reached. Increases in heatwave intensity are generally 0.5-1.5 °C above a given global warming threshold, however are higher over the Mediterranean and Central Asian regions. Between warming thresholds of 1.5 °C and 2.5 °C, the return intervals of intense heatwaves reduce by 2-3 fold. Heatwave duration is projected to increase by 2-10 days/°C, with larger changes over lower latitudes. Analysis of two climate model ensembles indicate that variation in the rate of heatwave changes is dependent on physical differences between different climate models, however internal climate variability bears considerable influence on the expected range of regional heatwave changes per warming threshold. The results of this study reiterate the potential for disastrous consequences associated with regional heatwaves if global mean warming is not limited to 2 degrees.

Plankton Production, Fish Catch, and the Potential for Sharp Regional Catch Trends Under Climate Change

NASA Astrophysics Data System (ADS)

Stock, C. A.; John, J. G.; Lam, V.; Rykaczewski, R. R.; Cheung, W. W. L.; Dunne, J. P.; Asch, R. G.; Sarmiento, J. L.

2016-02-01

Fish catch has been related to diverse plankton metrics with often ambiguous mechanistic linkages to fish and varying degrees of spatial and temporal robustness. Proposed fish catch indicators also exhibit different patterns of variability and projected change, hindering fisheries assessments and the formulation of resilient marine resource management strategies. We combine 1) a new catch reconstruction featuring improved estimates of illegal and under-reported catch, 2) a novel high-resolution global Earth System Model (GFDL-ESM2.6) featuring 10 km ocean resolution and regionally robust patterns of carbon flow through the planktonic food web, and 3) simple fish trophodynamic considerations, and revisit the relationship between catch and planktonic food web fluxes in a more mechanistic context. Realized 20-year peak catches across globally distributed coastal regions could be well explained by the estimated planktonic production available to fish (via mesozooplankton and the flux of carbon to the benthos) after accounting for the catch trophic level (r = 0.64, r = 0.74 after removing lightly fished Australian systems). Similar skill, however, could result from models invoking high trophic efficiencies within the fish food web and a modest fraction of energy available to fish taken as catch, or low trophic efficiencies and a high fraction. Projections using either parameter combination suggest that projected regional changes in fish yields may be considerably larger than those implied from primary production.

Ellipticities of Elliptical Galaxies in Different Environments

NASA Astrophysics Data System (ADS)

Chen, Cheng-Yu; Hwang, Chorng-Yuan; Ko, Chung-Ming

2016-10-01

We studied the ellipticity distributions of elliptical galaxies in different environments. From the ninth data release of the Sloan Digital Sky Survey, we selected galaxies with absolute {r}\\prime -band magnitudes between -21 and -22. We used the volume number densities of galaxies as the criterion for selecting the environments of the galaxies. Our samples were divided into three groups with different volume number densities. The ellipticity distributions of the elliptical galaxies differed considerably in these three groups of different density regions. We deprojected the observed 2D ellipticity distributions into intrinsic 3D shape distributions, and the result showed that the shapes of the elliptical galaxies were relatively spherically symmetric in the high density region (HDR) and that relatively more flat galaxies were present in the low density region (LDR). This suggests that the ellipticals in the HDRs and LDRs have different origins or that different mechanisms might be involved. The elliptical galaxies in the LDR are likely to have evolved from mergers in relatively anisotropic structures, such as filaments and webs, and might contain information on the anisotropic spatial distribution of their parent mergers. By contrast, elliptical galaxies in the HDR might be formed in more isotropic structures, such as galaxy clusters, or they might encounter more torqueing effects compared with galaxies in LDRs, thereby becoming rounder.

Trends in child immunization across geographical regions in India: focus on urban-rural and gender differentials.

PubMed

Singh, Prashant Kumar

2013-01-01

Although child immunization is regarded as a highly cost-effective lifesaver, about fifty percent of the eligible children aged 12-23 months in India are without essential immunization coverage. Despite several programmatic initiatives, urban-rural and gender difference in child immunization pose an intimidating challenge to India's public health agenda. This study assesses the urban-rural and gender difference in child immunization coverage during 1992-2006 across six major geographical regions in India. Three rounds of the National Family Health Survey (NFHS) conducted during 1992-93, 1998-99 and 2005-06 were analyzed. Bivariate analyses, urban-rural and gender inequality ratios, and the multivariate-pooled logistic regression model were applied to examine the trends and patterns of inequalities over time. The analysis of change over one and half decades (1992-2006) shows considerable variations in child immunization coverage across six geographical regions in India. Despite a decline in urban-rural and gender differences over time, children residing in rural areas and girls remained disadvantaged. Moreover, northeast, west and south regions, which had the lowest gender inequality in 1992 observed an increase in gender difference over time. Similarly, urban-rural inequality increased in the west region during 1992-2006. This study suggests periodic evaluation of the health care system is vital to assess the between and within group difference beyond average improvement. It is essential to integrate strong immunization systems with broad health systems and coordinate with other primary health care delivery programs to augment immunization coverage.

Pharmacological Findings on the Biochemical Bases of Memory Processes: A General View

PubMed Central

Izquierdo, Iván; Cammarota, Martín; Medina, Jorge H.; Bevilaqua, Lia R. M.

2004-01-01

We have advanced considerably in the past 2 to 3 years in understanding the molecular mechanisms of consolidation, retrieval, and extinction of memories, particularly of fear memory. This advance was mainly due to pharmacological studies in many laboratories using localized brain injections of molecularly specific substances. One area in which significant advances have been made is in understanding that many different brain structures are involved in different memories, and that often several brain regions are involved in processing the same memory. These regions can cooperate or compete with each other, depending on circumstances that are beginning to be identified quite clearly. Another aspect in which major advances were made was retrieval and post-retrieval events, especially extinction, pointing to new therapeutic approaches to fearmotivated mental disorders. PMID:15656267

Quark-gluon discrimination in the search for gluino pair production at the LHC

DOE PAGES

Bhattacherjee, Biplob; Mukhopadhyay, Satyanarayan; Nojiri, Mihoko M.; ...

2017-01-11

Here, we study the impact of including quark- and gluon-initiated jet discrimination in the search for strongly interacting supersymmetric particles at the LHC. Taking the example of gluino pair production, considerable improvement is observed in the LHC search reach on including the jet substructure observables to the standard kinematic variables within a multivariate analysis. In particular, quark and gluon jet separation has higher impact in the region of intermediate mass-gap between the gluino and the lightest neutralino, as the difference between the signal and the standard model background kinematic distributions is reduced in this region. We also compare the predictionsmore » from different Monte Carlo event generators to estimate the uncertainty originating from the modelling of the parton shower and hadronization processes.« less

Using climate response functions in analyzing electricity production variables. A case study from Norway.

NASA Astrophysics Data System (ADS)

Tøfte, Lena S.; Martino, Sara; Mo, Birger

2016-04-01

This study analyses whether and to which extent today's hydropower system and reservoirs in Mid-Norway are able to balance new intermittent energy sources in the region, in both today's and tomorrow's climate. We also investigate if the electricity marked model EMPS gives us reasonable results also when run in a multi simulation mode without recalibration. Climate related energy (CRE) is influenced by the weather, the system for energy production and transport, and by market mechanisms. In the region of Mid-Norway, nearly all power demand is generated by hydro-electric facilities. Due to energy deficiency and limitations in the power grid the region experiences a deficit of electricity. The region is likely to experience considerable investments in wind power and small-scale hydropower and the transmission grid within and out of the region will probably be extended, so this situation might change. In addition climate change scenarios for the region agree on higher temperatures, more precipitation in total and a larger portion of the precipitation coming as rain instead of snow, as well as we expect slightly higher wind speed and more storms during the winter. Changing temperatures will also change the electricity demand. EMPS is a tool for forecasting and planning in electricity markets, developed for optimization and simulation of hydrothermal power systems with a considerable share of hydro power. It takes into account transport constraints and hydrological differences between major areas or regional subsystems. During optimization the objective is to minimize the expected cost in the whole system subject to all constraints. Incremental water values (marginal costs for hydropower) are computed for each area using stochastic dynamic programming. A heuristic approach is used to treat the interaction between areas. In the simulation part of the model total system costs are minimized week by week for each climate scenario in a linear problem formulation. A detailed representation of hydropower is included and total hydro power production for each area is calculated, and the production is distributed among all available plants within each area. During simulation, the demand is affected by prices and temperatures. 6 different infrastructure scenarios of wind and power line development are analyzed. The analyses are done by running EMPS calibrated for today's situation for 11*11*8 different combinations of altered weather variables (temperature, precipitation and wind) describing different climate change scenarios, finding the climate response function for every EMPS-variable according the electricity production, such as prices and income, energy balances (supply, consumption and trade), overflow losses, probability of curtailment etc .

Sleep spindles in humans: insights from intracranial EEG and unit recordings

PubMed Central

Andrillon, Thomas; Nir, Yuval; Staba, Richard J.; Ferrarelli, Fabio; Cirelli, Chiara; Tononi, Giulio; Fried, Itzhak

2012-01-01

Sleep spindles are an electroencephalographic (EEG) hallmark of non-rapid eye movement (NREM) sleep and are believed to mediate many sleep-related functions, from memory consolidation to cortical development. Spindles differ in location, frequency, and association with slow waves, but whether this heterogeneity may reflect different physiological processes and potentially serve different functional roles remains unclear. Here we utilized a unique opportunity to record intracranial depth EEG and single-unit activity in multiple brain regions of neurosurgical patients to better characterize spindle activity in human sleep. We find that spindles occur across multiple neocortical regions, and less frequently also in the parahippocampal gyrus and hippocampus. Most spindles are spatially restricted to specific brain regions. In addition, spindle frequency is topographically organized with a sharp transition around the supplementary motor area between fast (13-15Hz) centroparietal spindles often occurring with slow wave up-states, and slow (9-12Hz) frontal spindles occurring 200ms later on average. Spindle variability across regions may reflect the underlying thalamocortical projections. We also find that during individual spindles, frequency decreases within and between regions. In addition, deeper sleep is associated with a reduction in spindle occurrence and spindle frequency. Frequency changes between regions, during individual spindles, and across sleep may reflect the same phenomenon, the underlying level of thalamocortical hyperpolarization. Finally, during spindles neuronal firing rates are not consistently modulated, although some neurons exhibit phase-locked discharges. Overall, anatomical considerations can account well for regional spindle characteristics, while variable hyperpolarization levels can explain differences in spindle frequency. PMID:22159098

Investigating and comparing energy and macronutrient intake in female aerobic athletes in two different socio-economic regions

PubMed Central

Darvishi, Leila; Rabbani, Zahra; Goodarzy, Sima; Askari, Gholamreza; Shiranian, Afshin; Salehi, Mohammad; Borzooe, Azam; Ghiasvand, Reza

2012-01-01

Background: The purpose of this study was to assess nutritional intakes of female aerobic athletes in two different socio-economic classes in city of Isfahan. Materials and Methods: The participants of this analytical study were 99 female aerobic athletes aged between 15 and 50 years old who were randomly sampled (50 females in low economic region and 49 females in high economic region). The demographic details were collected by a questionnaire, and anthropometric indexes including height, weight, and waste circumference were measured using a tape measure and a scale. They filled out the 24-hour food recall questionnaire for two consecutive days in order to obtain their nutritional information. To analyze the data, Nutritionist 4 and SPSS18 software were used. Results: The means of energy intake in high and low regions were 1479.19 ± 561.86 and 1300.68 ± 498.354 kcal, respectively. There was no significant difference in terms of energy intake between these two groups (P = 0.98). The means of protein intake in low and high socio-economic classes were 17.41 ± 5.85 and 54.48 ± 6.62, respectively, and no significant differences were observed between these two regions (P = 0/606). The means of carbohydrate intake were 61.85 ± 9.76 and 54.48 ± 6.62 in the low and high socio-economic classes with a significant difference between them (P < 0.001). The mean of carbohydrate intake in the low socio-economic class was considerably higher than that in the high socio-economic class. The means of fat intake were 23.88 ± 8.24% and 30.07 ± 6.68% in the low and high socio-economic classes, respectively, and the means of fat intake in the high socio-economic region was significantly higher than that in the low socio-economic region (P < 0/001). Conclusion: The findings of this study indicated that the intakes of fat and carbohydrate were significantly different in the two different socio-economic regions in city of Isfahan. This difference could be attributed to different food patterns in these two regions. PMID:23555143

The Effects of Defense and Security on Capital Formation in Africa: An Empirical Investigation

DTIC Science & Technology

1988-09-01

costs in forgone investment of defense. An econometric model is constructed and applied to data from 27 Sub-Saharan African countries from 1971 through...undeniably greater homogeneity among African countries than among developing countries from different regions. Most of the countries considered here...alter our conclusions. Despite these similarities, there is considerable variation among African countries as well. About one-third of the countries

Local or distributed activation? The view from biology

NASA Astrophysics Data System (ADS)

Reimers, Mark

2011-06-01

There is considerable disagreement among connectionist modellers over whether to represent distinct properties by distinct nodes of a network or whether properties should be represented by patterns of activity across all nodes. This paper draws on the literature of neuroscience to say that a more subtle way of describing how different brain regions contribute to a behaviour, in terms of individual learning and in terms of degrees of importance, may render the current debate moot: both sides of the 'localist' versus 'distributed' debate emphasise different aspects of biology.

Entrenched geographical and socioeconomic disparities in child mortality: trends in absolute and relative inequalities in Cambodia.

PubMed

Jimenez-Soto, Eliana; Durham, Jo; Hodge, Andrew

2014-01-01

Cambodia has made considerable improvements in mortality rates for children under the age of five and neonates. These improvements may, however, mask considerable disparities between subnational populations. In this paper, we examine the extent of the country's child mortality inequalities. Mortality rates for children under-five and neonates were directly estimated using the 2000, 2005 and 2010 waves of the Cambodian Demographic Health Survey. Disparities were measured on both absolute and relative scales using rate differences and ratios, and where applicable, slope and relative indices of inequality by levels of rural/urban location, regions and household wealth. Since 2000, considerable reductions in under-five and to a lesser extent in neonatal mortality rates have been observed. This mortality decline has, however, been accompanied by an increase in relative inequality in both rates of child mortality for geography-related stratifying markers. For absolute inequality amongst regions, most trends are increasing, particularly for neonatal mortality, but are not statistically significant. The only exception to this general pattern is the statistically significant positive trend in absolute inequality for under-five mortality in the Coastal region. For wealth, some evidence for increases in both relative and absolute inequality for neonates is observed. Despite considerable gains in reducing under-five and neonatal mortality at a national level, entrenched and increased geographical and wealth-based inequality in mortality, at least on a relative scale, remain. As expected, national progress seems to be associated with the period of political and macroeconomic stability that started in the early 2000s. However, issues of quality of care and potential non-inclusive economic growth might explain remaining disparities, particularly across wealth and geography markers. A focus on further addressing key supply and demand side barriers to accessing maternal and child health care and on the social determinants of health will be essential in narrowing inequalities.

An ethnobotanical survey of medicinal plants used in the Siwai and Buin districts of the Autonomous Region of Bougainville

PubMed Central

Waruruai, Julie; Sipana, Beuluah; Koch, Michael; Barrows, Louis R.; Matainaho, Teatulohi K.; Rai, Prem P

2011-01-01

Ethnopharmacological relevance Traditional knowledge of medicinal plant use in many regions of Papua New Guinea and the Autonomous Region of Bougainville is poorly described and rapidly disappearing. A program initiated by the University of Papua New Guinea to systematically document and preserve traditional knowledge of medicinal plant use was initiated with WHO help in 2001. Aim of the study To document and compare medicinal plant use in the Siwai and Buin Districts of the Island of Bougainville. Siwai and Buin districts represent two adjacent geographic regions of differing language traditions. Materials and methods This report is a combination of two University of Papua New Guinea reports generated using a University of Papua New Guinea and Papua New Guinea Department of Health approved survey questionnaire “Information sheet on traditional herbal reparations and medicinal plants of Papua New Guinea”. Results Although Siwai and Buin Districts are adjacent in Southern Bougainville, there is considerable variation in the specific plants used medicinally and the specific uses of those plants that are used commonly in the two regions. In addition, many of the plants used in the region are widely distributed species that are used medicinally in other settings. Nevertheless, the high endemicity of plants and the extraordinary cultural diversity in the Autonomous Region of Bougainville has yielded description of the medicinal use of many plants that have not previously been reported in the wider scientific literature. Conclusions Efforts to document and preserve traditional knowledge of plant use in Papua New Guinea have yielded important new records of plants with potential application in the provision of health care for a developing nation with an under developed Western style rural health care system. This report documents substantial commonality in the general modes of medicinal plant preparation and in the health care applications of plant use in the Siwai and Buin traditions, however, there was considerable difference noted in the particular uses of the specific plants used in one or another of the districts. PMID:22004894

Divergent and nonuniform gene expression patterns in mouse brain

PubMed Central

Morris, John A.; Royall, Joshua J.; Bertagnolli, Darren; Boe, Andrew F.; Burnell, Josh J.; Byrnes, Emi J.; Copeland, Cathy; Desta, Tsega; Fischer, Shanna R.; Goldy, Jeff; Glattfelder, Katie J.; Kidney, Jolene M.; Lemon, Tracy; Orta, Geralyn J.; Parry, Sheana E.; Pathak, Sayan D.; Pearson, Owen C.; Reding, Melissa; Shapouri, Sheila; Smith, Kimberly A.; Soden, Chad; Solan, Beth M.; Weller, John; Takahashi, Joseph S.; Overly, Caroline C.; Lein, Ed S.; Hawrylycz, Michael J.; Hohmann, John G.; Jones, Allan R.

2010-01-01

Considerable progress has been made in understanding variations in gene sequence and expression level associated with phenotype, yet how genetic diversity translates into complex phenotypic differences remains poorly understood. Here, we examine the relationship between genetic background and spatial patterns of gene expression across seven strains of mice, providing the most extensive cellular-resolution comparative analysis of gene expression in the mammalian brain to date. Using comprehensive brainwide anatomic coverage (more than 200 brain regions), we applied in situ hybridization to analyze the spatial expression patterns of 49 genes encoding well-known pharmaceutical drug targets. Remarkably, over 50% of the genes examined showed interstrain expression variation. In addition, the variability was nonuniformly distributed across strain and neuroanatomic region, suggesting certain organizing principles. First, the degree of expression variance among strains mirrors genealogic relationships. Second, expression pattern differences were concentrated in higher-order brain regions such as the cortex and hippocampus. Divergence in gene expression patterns across the brain could contribute significantly to variations in behavior and responses to neuroactive drugs in laboratory mouse strains and may help to explain individual differences in human responsiveness to neuroactive drugs. PMID:20956311

[Decubitus ulcer in the calcaneus region: rapid development, difficult recovery].

PubMed

Fugazza, G; Bona, F

1996-03-01

Heel pressure sores frequently arise in patients kept in bed for a long time independently of their primary disease. In account of this event the authors completed a study concerning possible mutual relations between heel pressure sores and primary disease of the patients; to validate the pharmacological treatment in less severe sores and the surgical resolution in more serious cutaneous lesions. In the last 3 years (1992-1995) at the Rehabilitation Centre of Montescano the authors have treated 39 patients suffering from 63 different severe cutaneous lesions: from phlycten to deep necrosis. The therapeutic plane utilized pharmacological treatment for 1st, 2nd, 3rd degree pressure sores, and surgical treatment for 4th degree. Pharmacological treatment included: enzymatic drugs, bactericidal and bacteriostatic medicines and cicatrizing substances. Different healing times were related to different pressure sore severity. Surgical treatment consisted of transposition of flap into wound defect. This system caused considerable reduction in resolution times. The authors noticed how easily pressure sores arise in the heel region, and how difficultly they heal. This is probably connected with particular anatomical and vascular characteristics of this region.

Chronic Respiratory Diseases in the Regions of Northern Russia: Epidemiological Distinctions in the Results of a National Population Study.

PubMed

Gambaryan, Marine H; Shalnova, Svetlana A; Deev, Alexander D; Drapkina, Oxana M

2017-07-26

The aim of the study is to investigate the epidemiological situation regarding chronic respiratory diseases in populations that inhabit different climatic-geographical regions of Russia, and to develop targeted programs for prevention of these diseases. (1) a comparative analysis of the standardized mortality data in Russia and other selected regions of the Russian North using the European standard for respiratory diseases, in a population aged 25-64; and (2) data from a randomized cross-sectional epidemiological study, with subjects from three different climatic-geographical regions of Russia. (1) the respiratory disease-related mortality rates in the majority of Russian Northern regions were much higher compared to the national average. Although death rates from chronic lower respiratory diseases were higher among the Northern regions and in the whole of Russia relative to the countries of European Union (EU), the cause of death in the populations of the Northern regions tend to be lower respiratory infections and pneumonia; and (2) despite the absence of any significant differences in the prevalence of smoking, the prevalence of chronic respiratory diseases (COPD) is significantly higher in Far North Yakutsk compared to the other two regions in this study-Chelyabinsk and Vologda. The status of hyperborean had the highest chance of a significant contribution to COPD and cardiorespiratory pathology among all other risk factors. The results revealed a need for effective targeted strategies for primary and secondary prevention of chronic respiratory diseases for the populations of the Northern regions of Russia. The revealed regional distinctions regarding the prevalence of, and mortality from, chronic respiratory diseases should be taken into consideration when designing integrated programs for chronic non-communicable disease prevention in these regions.

Microchemical Pen: An Open Microreactor for Region-Selective Surface Modification.

PubMed

Mao, Sifeng; Sato, Chiho; Suzuki, Yuma; Yang, Jianmin; Zeng, Hulie; Nakajima, Hizuru; Yang, Ming; Lin, Jin-Ming; Uchiyama, Katsumi

2016-10-18

Various micro surface-modification approaches including photolithography, dip-pen lithography and ink-jet systems have been developed and used to extend the functionalities of solid surfaces. While those approaches work in the "open space", push-pull systems which work in solutions have recently drawn considerable attention. However, the confining flows performed by push-pull systems have realized only the dispense process, while microscale, region-selective chemical reactions have remained unattainable. This study reports a microchemical pen that enables region-selective chemical reactions for the micro surface modification/patterning. The chemical pen is based on the principle of microfluidic laminar flows and the resulting mixing of reagents by the mutual diffusion. The tiny diffusion layer performs as the working region. This report represents the first demonstration of an open microreactor in which two different reagents react on a real solid sample. The multifunctional characteristics of the microchemical pen are confirmed by different types of reactions in many research areas, including inorganic chemistry, polymer science, electrochemistry and biological sample treatment. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bayesian sensitivity analysis of bifurcating nonlinear models

NASA Astrophysics Data System (ADS)

Becker, W.; Worden, K.; Rowson, J.

2013-01-01

Sensitivity analysis allows one to investigate how changes in input parameters to a system affect the output. When computational expense is a concern, metamodels such as Gaussian processes can offer considerable computational savings over Monte Carlo methods, albeit at the expense of introducing a data modelling problem. In particular, Gaussian processes assume a smooth, non-bifurcating response surface. This work highlights a recent extension to Gaussian processes which uses a decision tree to partition the input space into homogeneous regions, and then fits separate Gaussian processes to each region. In this way, bifurcations can be modelled at region boundaries and different regions can have different covariance properties. To test this method, both the treed and standard methods were applied to the bifurcating response of a Duffing oscillator and a bifurcating FE model of a heart valve. It was found that the treed Gaussian process provides a practical way of performing uncertainty and sensitivity analysis on large, potentially-bifurcating models, which cannot be dealt with by using a single GP, although an open problem remains how to manage bifurcation boundaries that are not parallel to coordinate axes.

Multi-Decadal Change of Atmospheric Aerosols and Their Effect on Surface Radiation

NASA Technical Reports Server (NTRS)

Chin, Mian; Diehl, Thomas; Tan, Qian; Wild, Martin; Qian, Yun; Yu, Hongbin; Bian, Huisheng; Wang, Weiguo

2012-01-01

We present an investigation on multi-decadal changes of atmospheric aerosols and their effects on surface radiation using a global chemistry transport model along with the near-term to long-term data records. We focus on a 28-year time period of satellite era from 1980 to 2007, during which a suite of aerosol data from satellite observations and ground-based remote sensing and in-situ measurements have become available. We analyze the long-term global and regional aerosol optical depth and concentration trends and their relationship to the changes of emissions" and assess the role aerosols play in the multi-decadal change of solar radiation reaching the surface (known as "dimming" or "brightening") at different regions of the world, including the major anthropogenic source regions (North America, Europe, Asia) that have been experiencing considerable changes of emissions, dust and biomass burning regions that have large interannual variabilities, downwind regions that are directly affected by the changes in the source area, and remote regions that are considered to representing "background" conditions.

48 CFR 907.105 - Contents of written acquisition plans.

Code of Federal Regulations, 2010 CFR

2010-10-01

... acquisition plans. (b)(16) Environmental and energy conservation objectives. Incorporate sustainable building considerations including building location and regional planning considerations into planning for new Federal...

On the emission coefficient of uranium plasmas.

NASA Technical Reports Server (NTRS)

Schneider, R. T.; Campbell, H. D.; Mack, J. M.

1973-01-01

The emission coefficient for uranium plasmas (temperature: 8000 K) was measured for the wavelength range from 1200 to 6000 A. The results were compared to theoretical calculations and other measurements. Reasonable agreement between theoretical predictions and our measurements was found in the region from 1200 to 2000 A. Although it was difficult to make absolute comparisons among the different reported measurements, considerable disagreement was found for the higher wavelength region. A short discussion regarding the overall comparisons is given, and final suggestions are made as to the most appropriate emission coefficient values to be used in future design calculations. The absorption coefficient for the same wavelength interval is also reported.

A novel shape from focus method based on 3D steerable filters for improved performance on treating textureless region

NASA Astrophysics Data System (ADS)

Fan, Tiantian; Yu, Hongbin

2018-03-01

A novel shape from focus method combining 3D steerable filter for improved performance on treating textureless region was proposed in this paper. Different from conventional spatial methods focusing on the search of maximum edges' response to estimate the depth map, the currently proposed method took both of the edges' response and the axial imaging blur degree into consideration during treatment. As a result, more robust and accurate identification for the focused location can be achieved, especially when treating textureless objects. Improved performance in depth measurement has been successfully demonstrated from both of the simulation and experiment results.

The organisation, operational dynamics and structure of female sex work in Pakistan.

PubMed

Emmanuel, Faran; Thompson, Laura H; Athar, Uzma; Salim, Momina; Sonia, Altaf; Akhtar, Naeem; Blanchard, James F

2013-09-01

Pakistan is known to have large populations of female sex workers (FSWs) with considerable geographic heterogeneity in their characteristics. In this paper, we describe the social organisation and structural patterns of female sex work in different geographic regions of Pakistan. We report geographic and network mapping data collected among FSWs in 15 cities across Pakistan in 2011 as part of the Canada-Pakistan HIV/AIDS Surveillance Project. A total number of 89 178 FSWs were estimated in the target cities for an average of 7.2 FSWs per 1000 adult males. 55% of the estimated number of FSWs concentrated in Karachi and Lahore. Based on the operations of female sex work, two major typologies of FSWs were identified: establishment-based and non-establishment-based. FSWs were further subtyped into those operating through brothels, homes, kothikhanas, streets and by cell phone. Cities varied considerably in terms of predominance of different FSW typologies. There is considerable heterogeneity among FSWs in Pakistan, geographically and in terms of operational typology. Understanding the social organisation of sex work and the influence of social-cultural and legal factors in Pakistan is essential for the design of HIV prevention programmes and other services for FSWs.

Characterising private and shared signatures of positive selection in 37 Asian populations.

PubMed

Liu, Xuanyao; Lu, Dongsheng; Saw, Woei-Yuh; Shaw, Philip J; Wangkumhang, Pongsakorn; Ngamphiw, Chumpol; Fucharoen, Suthat; Lert-Itthiporn, Worachart; Chin-Inmanu, Kwanrutai; Chau, Tran Nguyen Bich; Anders, Katie; Kasturiratne, Anuradhani; de Silva, H Janaka; Katsuya, Tomohiro; Kimura, Ryosuke; Nabika, Toru; Ohkubo, Takayoshi; Tabara, Yasuharu; Takeuchi, Fumihiko; Yamamoto, Ken; Yokota, Mitsuhiro; Mamatyusupu, Dolikun; Yang, Wenjun; Chung, Yeun-Jun; Jin, Li; Hoh, Boon-Peng; Wickremasinghe, Ananda R; Ong, RickTwee-Hee; Khor, Chiea-Chuen; Dunstan, Sarah J; Simmons, Cameron; Tongsima, Sissades; Suriyaphol, Prapat; Kato, Norihiro; Xu, Shuhua; Teo, Yik-Ying

2017-04-01

The Asian Diversity Project (ADP) assembled 37 cosmopolitan and ethnic minority populations in Asia that have been densely genotyped across over half a million markers to study patterns of genetic diversity and positive natural selection. We performed population structure analyses of the ADP populations and divided these populations into four major groups based on their genographic information. By applying a highly sensitive algorithm haploPS to locate genomic signatures of positive selection, 140 distinct genomic regions exhibiting evidence of positive selection in at least one population were identified. We examined the extent of signal sharing for regions that were selected in multiple populations and observed that populations clustered in a similar fashion to that of how the ancestry clades were phylogenetically defined. In particular, populations predominantly located in South Asia underwent considerably different adaptation as compared with populations from the other geographical regions. Signatures of positive selection present in multiple geographical regions were predicted to be older and have emerged prior to the separation of the populations in the different regions. In contrast, selection signals present in a single population group tended to be of lower frequencies and thus can be attributed to recent evolutionary events.

Characterising private and shared signatures of positive selection in 37 Asian populations

PubMed Central

Liu, Xuanyao; Lu, Dongsheng; Saw, Woei-Yuh; Shaw, Philip J; Wangkumhang, Pongsakorn; Ngamphiw, Chumpol; Fucharoen, Suthat; Lert-itthiporn, Worachart; Chin-inmanu, Kwanrutai; Chau, Tran Nguyen Bich; Anders, Katie; Kasturiratne, Anuradhani; de Silva, H Janaka; Katsuya, Tomohiro; Kimura, Ryosuke; Nabika, Toru; Ohkubo, Takayoshi; Tabara, Yasuharu; Takeuchi, Fumihiko; Yamamoto, Ken; Yokota, Mitsuhiro; Mamatyusupu, Dolikun; Yang, Wenjun; Chung, Yeun-Jun; Jin, Li; Hoh, Boon-Peng; Wickremasinghe, Ananda R; Ong, RickTwee-Hee; Khor, Chiea-Chuen; Dunstan, Sarah J; Simmons, Cameron; Tongsima, Sissades; Suriyaphol, Prapat; Kato, Norihiro; Xu, Shuhua; Teo, Yik-Ying

2017-01-01

The Asian Diversity Project (ADP) assembled 37 cosmopolitan and ethnic minority populations in Asia that have been densely genotyped across over half a million markers to study patterns of genetic diversity and positive natural selection. We performed population structure analyses of the ADP populations and divided these populations into four major groups based on their genographic information. By applying a highly sensitive algorithm haploPS to locate genomic signatures of positive selection, 140 distinct genomic regions exhibiting evidence of positive selection in at least one population were identified. We examined the extent of signal sharing for regions that were selected in multiple populations and observed that populations clustered in a similar fashion to that of how the ancestry clades were phylogenetically defined. In particular, populations predominantly located in South Asia underwent considerably different adaptation as compared with populations from the other geographical regions. Signatures of positive selection present in multiple geographical regions were predicted to be older and have emerged prior to the separation of the populations in the different regions. In contrast, selection signals present in a single population group tended to be of lower frequencies and thus can be attributed to recent evolutionary events. PMID:28098149

Obesity surgery in England: an examination of the health episode statistics 1996-2005.

PubMed

Ells, Louisa J; Macknight, Neil; Wilkinson, John R

2007-03-01

The authors examined the uptake of obesity surgery across England. Data were analyzed from the Hospital Episode Statistics covering all 9 goverment office regions with a total population of 49.1 million. The data analyzed covered 9 years 1996/97 - 2004/05. 1,465 records were identified with a primary diagnostic code for obesity and an operation code for obesity surgery. The surgery was performed mostly in women (male to female ratio of 1:5), who were predominantly mid-aged (average 40.4 years +/- SD 9.00), the majority of whom reside in local authority districts ranked within the lowest two deprivation quintiles. The availability of obesity surgery varied considerably across the 9 different regions of England, although the number of operations increased nationally over time. Access to this intervention is highly variable and does not appear to reflect estimated regional differences in morbid obesity. This specialist service may benefit from more effective national organization, to ensure appropriate capacity and eliminate inequalities in service delivery.

The fascia of the limbs and back – a review

PubMed Central

Benjamin, Mike

2009-01-01

Although fasciae have long interested clinicians in a multitude of different clinical and paramedical disciplines, there have been few attempts to unite the ensuing diverse literature into a single review. The current article gives an anatomical perspective that extends from the gross to the molecular level. For expediency, it deals only with fascia in the limbs and back. Particular focus is directed towards deep fascia and thus consideration is given to structures such as the fascia lata, thoracolumbar fascia, plantar and palmar fascia, along with regional specializations of deep fascia such as retinacula and fibrous pulleys. However, equal emphasis is placed on general aspects of fascial structure and function, including its innervation and cellular composition. Among the many functions of fascia considered in detail are its ectoskeletal role (as a soft tissue skeleton for muscle attachments), its importance for creating osteofascial compartments for muscles, encouraging venous return in the lower limb, dissipating stress concentration at entheses and acting as a protective sheet for underlying structures. Emphasis is placed on recognizing the continuity of fascia between regions and appreciating its key role in coordinating muscular activity and acting as a body-wide proprioceptive organ. Such considerations far outweigh the significance of viewing fascia in a regional context alone. PMID:19166469

Activity patterns of extrinsic finger flexors and extensors during movements of instructed and non-instructed fingers.

PubMed

van Beek, Nathalie; Stegeman, Dick F; van den Noort, Josien C; H E J Veeger, DirkJan; Maas, Huub

2018-02-01

The fingers of the human hand cannot be controlled fully independently. This phenomenon may have a neurological as well as a mechanical basis. Despite previous studies, the neuromechanics of finger movements are not fully understood. The aims of this study were (1) to assess the activation and coactivation patterns of finger specific flexor and extensor muscle regions during instructed single finger flexion and (2) to determine the relationship between enslaved finger movements and respective finger muscle activation. In 9 healthy subjects (age 22-29), muscle activation was assessed during single finger flexion using a 90 surface electromyography electrode grid placed over the flexor digitorum superficialis (FDS) and the extensor digitorum (ED). We found (1) no significant differences in muscle activation timing between fingers, (2) considerable muscle activity in flexor and extensor regions associated with the non-instructed fingers and (3) no correlation between the muscle activations and corresponding movement of non-instructed fingers. A clear disparity was found between the movement pattern of the non-instructed fingers and the activity pattern of the corresponding muscle regions. This suggests that mechanical factors, such as intertendinous and myofascial connections, may also affect finger movement independency and need to be taken into consideration when studying finger movement. Copyright © 2017 Elsevier Ltd. All rights reserved.

A review of the global relationship among freshwater fish, autotrophic activity, and regional climate

USGS Publications Warehouse

Deines, Andrew M.; Bunnell, David B.; Rogers, Mark W.; Beard, T. Douglas; Taylor, William W.

2015-01-01

The relationship between autotrophic activity and freshwater fish populations is an important consideration for ecologists describing trophic structure in aquatic communities, fisheries managers tasked with increasing sustainable fisheries development, and fish farmers seeking to maximize production. Previous studies of the empirical relationships of autotrophic activity and freshwater fish yield have found positive relationships but were limited by small sample sizes, small geographic scopes, and the inability to compare patterns among many types of measurement techniques. Individual studies and reviews have also lacked consistent consideration of regional climate factors which may inform relationships between fisheries and autotrophic activity. We compiled data from over 700 freshwater systems worldwide and used meta-analysis and linear models to develop a comprehensive global synthesis between multiple metrics of autotrophic activity, fisheries, and climate indicators. Our results demonstrate that multiple metrics of fish (i.e., catch per unit effort, yield, and production) increase with autotrophic activity across a variety of fisheries. At the global scale additional variation in this positive relationship can be ascribed to regional climate differences (i.e., temperature and precipitation) across systems. Our results provide a method and proof-of-concept for assessing inland fisheries production at the global scale, where current estimates are highly uncertain, and may therefore inform the continued sustainable use of global inland fishery resources.

The Genomic Ancestry of Individuals from Different Geographical Regions of Brazil Is More Uniform Than Expected

PubMed Central

Pena, Sérgio D. J.; Di Pietro, Giuliano; Fuchshuber-Moraes, Mateus; Genro, Julia Pasqualini; Hutz, Mara H.; Kehdy, Fernanda de Souza Gomes; Kohlrausch, Fabiana; Magno, Luiz Alexandre Viana; Montenegro, Raquel Carvalho; Moraes, Manoel Odorico; de Moraes, Maria Elisabete Amaral; de Moraes, Milene Raiol; Ojopi, Élida B.; Perini, Jamila A.; Racciopi, Clarice; Ribeiro-dos-Santos, Ândrea Kely Campos; Rios-Santos, Fabrício; Romano-Silva, Marco A.; Sortica, Vinicius A.; Suarez-Kurtz, Guilherme

2011-01-01

Based on pre-DNA racial/color methodology, clinical and pharmacological trials have traditionally considered the different geographical regions of Brazil as being very heterogeneous. We wished to ascertain how such diversity of regional color categories correlated with ancestry. Using a panel of 40 validated ancestry-informative insertion-deletion DNA polymorphisms we estimated individually the European, African and Amerindian ancestry components of 934 self-categorized White, Brown or Black Brazilians from the four most populous regions of the Country. We unraveled great ancestral diversity between and within the different regions. Especially, color categories in the northern part of Brazil diverged significantly in their ancestry proportions from their counterparts in the southern part of the Country, indicating that diverse regional semantics were being used in the self-classification as White, Brown or Black. To circumvent these regional subjective differences in color perception, we estimated the general ancestry proportions of each of the four regions in a form independent of color considerations. For that, we multiplied the proportions of a given ancestry in a given color category by the official census information about the proportion of that color category in the specific region, to arrive at a “total ancestry” estimate. Once such a calculation was performed, there emerged a much higher level of uniformity than previously expected. In all regions studied, the European ancestry was predominant, with proportions ranging from 60.6% in the Northeast to 77.7% in the South. We propose that the immigration of six million Europeans to Brazil in the 19th and 20th centuries - a phenomenon described and intended as the “whitening of Brazil” - is in large part responsible for dissipating previous ancestry dissimilarities that reflected region-specific population histories. These findings, of both clinical and sociological importance for Brazil, should also be relevant to other countries with ancestrally admixed populations. PMID:21359226

Transmission of sound across a vortex layer enclosing a cylindrical column of jet

NASA Technical Reports Server (NTRS)

Luh, R.; Chao, C. C.

1982-01-01

An approximate solution to the problem of transmission of sound across a cylindrical vortex was obtained. Results are considerably different from the plane vortex sheet case because of the added role played by the curvature of the jet. In comparison with the plane case, the specularly transmitted waves are more complex and require some numerical integration. Resonance waves are identically predicted for M 2, but there is also a wave field whose modified effect appears to extend the region of resonance just as the instability waves cover a region in space and time. The instability waves are predicted to exist for all Mach numbers but vanish for wavelengths that are large compared to the jet radius. The region of propagation is similarly wavelength dependent.

Hepatitis C Virus in North Africa: An Emerging Threat.

PubMed

Daw, Mohamed A; El-Bouzedi, Abdallah; Ahmed, Mohamed O; Dau, Aghnyia A; Agnan, Mohamed M

2016-01-01

Hepatitis C virus is a major public health threat associated with serious clinical consequences worldwide. North Africa is a unique region composed of seven countries that vary considerably in the predisposing factors to microbial diseases both historically and at the present time. The dynamics of HCV in the region are not well documented. The data are both limited and controversial in most of the countries in the region. In North Africa, the epidemiology of HCV is disparate and understanding it has been hampered by regional "epidemiological homogeneity" concepts. As the dynamics of HCV vary from country to country, context-specific research is needed. In this review, we assess studies performed in each country in the general populations as well as among blood donors and groups exposed to the HCV infection. The reported prevalence of HCV ranges from 0.6% to 8.4% in the Maghreb countries and is predominated by genotype 1. In the Nile valley region, it ranges from 2.2% to 18.9% and is dominated by genotype 4. In North African countries, HCV seems to be a serious problem that is driven by different vectors even in different geographical locations within the same country. Efforts should be combined at both the national and regional levels to implement efficient preventive and treatment strategies.

Hepatitis C Virus in North Africa: An Emerging Threat

PubMed Central

El-Bouzedi, Abdallah; Dau, Aghnyia A.; Agnan, Mohamed M.

2016-01-01

Hepatitis C virus is a major public health threat associated with serious clinical consequences worldwide. North Africa is a unique region composed of seven countries that vary considerably in the predisposing factors to microbial diseases both historically and at the present time. The dynamics of HCV in the region are not well documented. The data are both limited and controversial in most of the countries in the region. In North Africa, the epidemiology of HCV is disparate and understanding it has been hampered by regional “epidemiological homogeneity” concepts. As the dynamics of HCV vary from country to country, context-specific research is needed. In this review, we assess studies performed in each country in the general populations as well as among blood donors and groups exposed to the HCV infection. The reported prevalence of HCV ranges from 0.6% to 8.4% in the Maghreb countries and is predominated by genotype 1. In the Nile valley region, it ranges from 2.2% to 18.9% and is dominated by genotype 4. In North African countries, HCV seems to be a serious problem that is driven by different vectors even in different geographical locations within the same country. Efforts should be combined at both the national and regional levels to implement efficient preventive and treatment strategies. PMID:27610403

Considerations Taken in Developing the Frequency Assignment Guidelines for Communications in the Mars Region Provided in SFCG Recommendation 22-1, (SFCG Action Item No. 23/10)

NASA Technical Reports Server (NTRS)

Wang, Charles C.; Peng, Ted; Sue, Miles K.

2004-01-01

In the 23'd Annual SFCG meeting in San Diego, CA, the SFCG created SFCG Action Item No. 23/10 to provide a readable summary of the work done by the Mars Interim Working Group (MIWG). The SFCG created the MIWG to develop a frequency plan for future Mars missions. The working group has produced a number of documents resulting in a recommendation, SFCG Rec 22-1 [1], titled Frequency Assignment Guidelines for Communications in Mars Region, including a frequency plan for the Mars Region. This document is prepared in response to the SFCG Action Item to provide an overview of the considerations taken when selecting the frequencies and to point out where detailed information of the considerations can be found.

A comparison between decomposition rates of buried and surface remains in a temperate region of South Africa.

PubMed

Marais-Werner, Anátulie; Myburgh, J; Becker, P J; Steyn, M

2018-01-01

Several studies have been conducted on decomposition patterns and rates of surface remains; however, much less are known about this process for buried remains. Understanding the process of decomposition in buried remains is extremely important and aids in criminal investigations, especially when attempting to estimate the post mortem interval (PMI). The aim of this study was to compare the rates of decomposition between buried and surface remains. For this purpose, 25 pigs (Sus scrofa; 45-80 kg) were buried and excavated at different post mortem intervals (7, 14, 33, 92, and 183 days). The observed total body scores were then compared to those of surface remains decomposing at the same location. Stages of decomposition were scored according to separate categories for different anatomical regions based on standardised methods. Variation in the degree of decomposition was considerable especially with the buried 7-day interval pigs that displayed different degrees of discolouration in the lower abdomen and trunk. At 14 and 33 days, buried pigs displayed features commonly associated with the early stages of decomposition, but with less variation. A state of advanced decomposition was reached where little change was observed in the next ±90-183 days after interment. Although the patterns of decomposition for buried and surface remains were very similar, the rates differed considerably. Based on the observations made in this study, guidelines for the estimation of PMI are proposed. This pertains to buried remains found at a depth of approximately 0.75 m in the Central Highveld of South Africa.

Perceptual load in different regions of the visual scene and its relevance for driving.

PubMed

Marciano, Hadas; Yeshurun, Yaffa

2015-06-01

The aim of this study was to better understand the role played by perceptual load, at both central and peripheral regions of the visual scene, in driving safety. Attention is a crucial factor in driving safety, and previous laboratory studies suggest that perceptual load is an important factor determining the efficiency of attentional selectivity. Yet, the effects of perceptual load on driving were never studied systematically. Using a driving simulator, we orthogonally manipulated the load levels at the road (central load) and its sides (peripheral load), while occasionally introducing critical events at one of these regions. Perceptual load affected driving performance at both regions of the visual scene. Critically, the effect was different for central versus peripheral load: Whereas load levels on the road mainly affected driving speed, load levels on its sides mainly affected the ability to detect critical events initiating from the roadsides. Moreover, higher levels of peripheral load impaired performance but mainly with low levels of central load, replicating findings with simple letter stimuli. Perceptual load has a considerable effect on driving, but the nature of this effect depends on the region of the visual scene at which the load is introduced. Given the observed importance of perceptual load, authors of future studies of driving safety should take it into account. Specifically, these findings suggest that our understanding of factors that may be relevant for driving safety would benefit from studying these factors under different levels of load at different regions of the visual scene. © 2014, Human Factors and Ergonomics Society.

Geological Study and Regional Development of Mamberamo Raya Disctrict of Papua Province, Indonesia

NASA Astrophysics Data System (ADS)

Tonggiroh, Adi; Asri Jaya, HS; Ria Irfan, Ulva

2018-02-01

The goverment of Mamberamo Raya district was established through Act No. 19 of 2007 dated 15 March 2007 as part of the administrative area of Papua Province. The administrative age of this district is relatively young requires hard work of all components in facing development challenges so that necessary strategic steps of vision and mission of regional development to achieve ideal conditions of spatial which as direction of the desired embodiment in the future. Regional development covers all technical aspects including the geological aspect that the area is located on the morphology of the mountains and Mamberamo watershed. Strategic steps require policy as an action to achieve the goal with the elaboration of operational steps to realize the welfare of peoples equally and sustainably according to the potential physiogeography of Mamberamo watershed. The geological aspect as the consideration of technical that this region belongs to the regional tectonic which is divided into the difference of fault in the north there is Yapen fault and in the south is Mamberamo-Gauttier Fault and also a consideration on the stratigraphic structure of various rock types including the dominance of sedimentary rocks. This study examines geological aspects as an element of earth science in spatial planning in Mamberamo district, especially Kasonaweja and Burmeso. The analysis is presented based on field data, in the form of geographical map data of geological structure, geological map, and earthquake data described by cluster pattern indicating regional motion relationship and rock characteristics that make up Mamberamo watershed. It finds land characteristics controlled by geological structures, rock arrangements and landforms in response to landslide, flood and seismic changes.

7 CFR 1486.103 - Are regional projects possible under the program?

Code of Federal Regulations, 2011 CFR

2011-01-01

... consideration provided such projects target qualifying emerging markets in the specified region. CCC may consider activities which target qualified emerging markets in a specific region, but are conducted in a...

40 CFR 230.91 - Purpose and general considerations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... done after taking into consideration cost, existing technology, and logistics in light of overall... national or regional level. No modifications to the basic application, meaning, or intent of this subpart...

Analysis of loci required for determination of serotype antigenicity in Streptococcus mutans and its clinical utilization.

PubMed

Shibata, Yukie; Ozaki, Kazuhisa; Seki, Mitsuko; Kawato, Takayuki; Tanaka, Hideki; Nakano, Yoshio; Yamashita, Yoshihisa

2003-09-01

We recently identified the genes responsible for the serotype c-specific glucose side chain formation of rhamnose-glucose polysaccharide (RGP) in Streptococcus mutans. These genes were located downstream from the rgpA through rgpF locus that is involved in the synthesis of RGP. In the present study, the corresponding chromosomal regions were isolated from serotype e and f strains and characterized. The rgpA through rgpF homologs were well conserved among the three serotypes. By contrast, the regions downstream from the rgpF homolog differed considerably among the three serotypes. Replacement of these regions in the different serotype strains converted their serotypic phenotypes, suggesting that these regions participated in serotype-specific glucose side chain formation in each serotype strain. Based on the differences among the DNA sequences of these regions, a PCR method was developed to determine serotypes. S. mutans was isolated from 198 of 432 preschool children (3 to 4 years old). The serotypes of all but one S. mutans isolate were identified by serotyping PCR. Serotype c predominated (84.8%), serotype e was the next most common (13.3%), and serotype f occured rarely (1.9%) in Japanese preschool children. Caries experience in the group with a mixed infection by multiple serotypes of S. mutans was significantly higher than that in the group with a monoinfection by a single serotype.

Where You Live Matters: Localising Environmental Impacts on Health, Nutrition and Poverty in Cambodia Using Small Area Estimation Techniques

NASA Astrophysics Data System (ADS)

Nilsen, K.; van Soesbergen, A.; Matthews, Z.

2016-12-01

Socioeconomic development depends on local environments. However, the scientific evidence quantifying the impact of environmental factors on health, nutrition and poverty at subnational levels is limited. This is because socioeconomic indicators are derived from sample surveys representative only at aggregate levels compared to environmental variables mostly available in high-resolution grids. Cambodia was selected because of its commitment to development in the context of a rapidly deteriorating environment. Having made considerable progress since 2005, access to health services is limited, a quarter of the population is still poor and 40% rural children are malnourished. Cambodia is also facing considerable environmental challenges including high deforestation rates, land degradation and natural hazards. Addressing existing gaps in the knowledge of environmental impacts on health and livelihoods, this study applies small area estimation (SAE) to quantify health, nutritional and poverty outcomes in the context of local environments. SAE produces reliable subnational estimates of socioeconomic outcomes available only from sample surveys by combining them with information from auxiliary sources (census). A model is used to explain common trades across areas and a random effect structure is applied to explain the observed extra heterogeneity. SAE models predicting health, nutrition and poverty outcomes excluding and including contextual environmental variables on natural hazards vulnerability, forest cover, climate, and agricultural production are compared. Results are mapped at regional and district levels to spatially assess the impacts of environmental variation on the outcomes. Inter and intra-regional inequalities are also estimated to examine the efficacy of health/socioeconomic policy targeting based on geographic location. Preliminary results suggest that localised environmental factors have considerable impacts on the indicators estimated and should therefore not be ignored. While there are large regional differences, pockets of malnutrition, poverty and inequitable health outcomes within regions are identified. The inequality decomposition shows under and over-coverage of geographical targeting when environmental factors are taken into account.

Variation in treatment strategies of Swiss general practitioners for subclinical hypothyroidism in older adults.

PubMed

Baumgartner, Christine; den Elzen, Wendy P J; Blum, Manuel R; Coslovsky, Michael; Streit, Sven; Frey, Peter; Herzig, Lilli; Haller, Dagmar M; Mooijaart, Simon P; Bischoff, Thomas; Rosemann, Thomas; Gussekloo, Jacobijn; Rodondi, Nicolas

2015-01-01

As the best management of subclinical hypothyroidism is controversial, we aimed to assess variations in treatment strategies depending on different Swiss regions, physician and patient characteristics. We performed a case-based survey among general practitioners (GPs) in different Swiss regions, which consisted of eight hypothetical cases presenting a female patient with subclinical hypothyroidism and nonspecific complaints differing by age, vitality status and thyroid-stimulating hormone (TSH) concentration. A total of 262 GPs participated in the survey. There was considerable variation in the levothyroxine starting dose chosen by GPs, ranging from 25 µg to 100 µg. Across the Swiss regions, GPs in the Bern region were significantly more inclined to treat, with a higher probability of initiating treatment (60%, p = 0.01) and higher mean starting doses (45 µg, p <0.01) compared with the French-speaking region (44%, 36 µg); the Zurich region had intermediate values (52%, 39 µg). We found no association between treatment rate and other physician characteristics. GPs were more reluctant to initiate treatment in 85-year-old than in 70-year-old women (odds ratio [OR] 0.77, 95% confidence interval [CI] 0.63-0.94), and more likely to treat women with a TSH of 15 mU/l than those with a TSH of 6mU/l (OR 8.71, 95% CI 6.21-12.20). There are strong variations in treatment strategies for elderly patients with subclinical hypothyroidism across different Swiss regions, including use of higher starting doses than the recommended 25 µg in the Swiss guidelines, which recommend a starting dose of 25 µg. These variations likely reflect the current uncertainty about the benefits of treatment, which arise from the current lack of evidence from adequately powered clinical trials.

Transmitter receptors reveal segregation of cortical areas in the human superior parietal cortex: relations to visual and somatosensory regions.

PubMed

Scheperjans, Filip; Palomero-Gallagher, Nicola; Grefkes, Christian; Schleicher, Axel; Zilles, Karl

2005-11-01

Regional distributions of ligand binding sites of 12 different neurotransmitter receptors (glutamatergic: AMPA, kainate, NMDA; GABAergic: GABA(A), GABA(B); cholinergic: muscarinic M2, nicotinic; adrenergic: alpha1, alpha2; serotonergic: 5-HT1A, 5-HT2; dopaminergic: D1) were studied in human postmortem brains by means of quantitative receptor autoradiography. Binding site densities were measured in the superior parietal lobule (SPL) (areas 5L, 5M, 5Ci, and different locations within Brodmann's area (BA) 7), somatosensory (BA 2), and visual cortical areas (BA 17, and different locations within BAs 18 and 19). Similarities of receptor distribution between cortical areas were analyzed by cluster analysis, uni- and multivariate statistics of mean receptor densities (averaged over all cortical layers), and profiles representing the laminar distribution patterns of receptors. A considerable heterogeneity of regional receptor densities and laminar patterns between the sites was found in the SPL and the visual cortex. The most prominent regional differences were found for M2 receptors. In the SPL, rostrocaudally oriented changes of receptor densities were more pronounced than those in mediolateral direction. The receptor distribution in the rostral SPL was more similar to that of the somatosensory cortex, whereas caudal SPL resembled the receptor patterns of the dorsolateral extrastriate visual areas. These results suggest a segregation of the different SPL areas based on receptor distribution features typical for somatosensory or visual areas, which fits to the dual functional role of this cortical region, i.e., the involvement of the human SPL in visuomotor and somatosensory motor transformations.

Trends in Child Immunization across Geographical Regions in India: Focus on Urban-Rural and Gender Differentials

PubMed Central

Singh, Prashant Kumar

2013-01-01

Background Although child immunization is regarded as a highly cost-effective lifesaver, about fifty percent of the eligible children aged 12–23 months in India are without essential immunization coverage. Despite several programmatic initiatives, urban-rural and gender difference in child immunization pose an intimidating challenge to India’s public health agenda. This study assesses the urban-rural and gender difference in child immunization coverage during 1992–2006 across six major geographical regions in India. Data and Methods Three rounds of the National Family Health Survey (NFHS) conducted during 1992–93, 1998–99 and 2005–06 were analyzed. Bivariate analyses, urban-rural and gender inequality ratios, and the multivariate-pooled logistic regression model were applied to examine the trends and patterns of inequalities over time. Key Findings The analysis of change over one and half decades (1992–2006) shows considerable variations in child immunization coverage across six geographical regions in India. Despite a decline in urban-rural and gender differences over time, children residing in rural areas and girls remained disadvantaged. Moreover, northeast, west and south regions, which had the lowest gender inequality in 1992 observed an increase in gender difference over time. Similarly, urban-rural inequality increased in the west region during 1992–2006. Conclusion This study suggests periodic evaluation of the health care system is vital to assess the between and within group difference beyond average improvement. It is essential to integrate strong immunization systems with broad health systems and coordinate with other primary health care delivery programs to augment immunization coverage. PMID:24023816

33 CFR 332.1 - Purpose and general considerations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... available and capable of being done after taking into consideration cost, existing technology, and logistics... and the Corps at the national or regional level. No modifications to the basic application, meaning...

Spatial econometric analysis of factors influencing regional energy efficiency in China.

PubMed

Song, Malin; Chen, Yu; An, Qingxian

2018-05-01

Increased environmental pollution and energy consumption caused by the country's rapid development has raised considerable public concern, and has become the focus of the government and public. This study employs the super-efficiency slack-based model-data envelopment analysis (SBM-DEA) to measure the total factor energy efficiency of 30 provinces in China. The estimation model for the spatial interaction intensity of regional total factor energy efficiency is based on Wilson's maximum entropy model. The model is used to analyze the factors that affect the potential value of total factor energy efficiency using spatial dynamic panel data for 30 provinces during 2000-2014. The study found that there are differences and spatial correlations of energy efficiency among provinces and regions in China. The energy efficiency in the eastern, central, and western regions fluctuated significantly, and was mainly because of significant energy efficiency impacts on influences of industrial structure, energy intensity, and technological progress. This research is of great significance to China's energy efficiency and regional coordinated development.

Spherically-symmetric solutions in general relativity using a tetrad-based approach

NASA Astrophysics Data System (ADS)

Kim, Do Young; Lasenby, Anthony N.; Hobson, Michael P.

2018-03-01

We present a tetrad-based method for solving the Einstein field equations for spherically-symmetric systems and compare it with the widely-used Lemaître-Tolman-Bondi (LTB) model. In particular, we focus on the issues of gauge ambiguity and the use of comoving versus `physical' coordinate systems. We also clarify the correspondences between the two approaches, and illustrate their differences by applying them to the classic examples of the Schwarzschild and Friedmann-Lemaître-Robertson-Walker spacetimes. We demonstrate that the tetrad-based method does not suffer from the gauge freedoms inherent to the LTB model, naturally accommodates non-uniform pressure and has a more transparent physical interpretation. We further apply our tetrad-based method to a generalised form of `Swiss cheese' model, which consists of an interior spherical region surrounded by a spherical shell of vacuum that is embedded in an exterior background universe. In general, we allow the fluid in the interior and exterior regions to support pressure, and do not demand that the interior region be compensated. We pay particular attention to the form of the solution in the intervening vacuum region and illustrate the validity of Birkhoff's theorem at both the metric and tetrad level. We then reconsider critically the original theoretical arguments underlying the so-called Rh = ct cosmological model, which has recently received considerable attention. These considerations in turn illustrate the interesting behaviour of a number of `horizons' in general cosmological models.

Performance, Defect Behavior and Carrier Enhancement in Low Energy, Proton Irradiated p(+)nn(+) InP Solar Cells

NASA Technical Reports Server (NTRS)

Weinberg, I.; Rybicki, G. C.; Vargas-Aburto, C.; Jain, R. K.; Scheiman, D.

1994-01-01

InP p(+)nn(+) cells, processed by MOCVD, were irradiated by 0.2 MeV protons and their performance and defect behavior observed to a maximum fluence of 10(exp 13)/sq cm. Their radiation induced degradation, over this fluence range, was considerably+less than observed for similarly irradiated, diffused junction n p InP cells. Significant degradation occurred in both the cell's emitter and base regions the least degradation occurring in the depletion region. A significant increase in series resistance occurs at the highest fluenc.e. Two majority carrier defect levels, E7 and E10, are observed by DLTS with activation energies at (E(sub C) - 0.39)eV and (E(sub C) - 0.74)eV respectively. The relative concentration of these defects differs considerably from that observed after 1 MeV electron irradiation. An increased carrier concentration in the cell's n-region was observed at the highest proton fluence, the change in carrier concentration being insignificant at the lower fluences. In agreement with previous results, for 1 and 1.5 MeV electron irradiated InP p(+)n junctions, the defect level E10 is attributed to a complex between zinc, diffused into the n-region from the zinc doped emitter, and a radiation induced defect. The latter is assumed to be either a phosphorus vacancy or interstitial. The increased, or enhanced carrier concentration is attributed to this complex acting as a donor.

The spliced leader trans-splicing mechanism in different organisms: molecular details and possible biological roles

PubMed Central

Bitar, Mainá; Boroni, Mariana; Macedo, Andréa M.; Machado, Carlos R.; Franco, Glória R.

2013-01-01

The spliced leader (SL) is a gene that generates a functional ncRNA that is composed of two regions: an intronic region of unknown function (SLi) and an exonic region (SLe), which is transferred to the 5′ end of independent transcripts yielding mature mRNAs, in a process known as spliced leader trans-splicing (SLTS). The best described function for SLTS is to solve polycistronic transcripts into monocistronic units, specifically in Trypanosomatids. In other metazoans, it is speculated that the SLe addition could lead to increased mRNA stability, differential recruitment of the translational machinery, modification of the 5′ region or a combination of these effects. Although important aspects of this mechanism have been revealed, several features remain to be elucidated. We have analyzed 157 SLe sequences from 148 species from seven phyla and found a high degree of conservation among the sequences of species from the same phylum, although no considerable similarity seems to exist between sequences of species from different phyla. When analyzing case studies, we found evidence that a given SLe will always be related to a given set of transcripts in different species from the same phylum, and therefore, different SLe sequences from the same species would regulate different sets of transcripts. In addition, we have observed distinct transcript categories to be preferential targets for the SLe addition in different phyla. This work sheds light into crucial and controversial aspects of the SLTS mechanism. It represents a comprehensive study concerning various species and different characteristics of this important post-transcriptional regulatory mechanism. PMID:24130571

Sequence and Characterization of the Ig Heavy Chain Constant and Partial Variable Region of the Mouse Strain 129S11

PubMed Central

Retter, Ida; Chevillard, Christophe; Scharfe, Maren; Conrad, Ansgar; Hafner, Martin; Im, Tschong-Hun; Ludewig, Monika; Nordsiek, Gabriele; Severitt, Simone; Thies, Stephanie; Mauhar, America; Blöcker, Helmut; Müller, Werner; Riblet, Roy

2009-01-01

Although the entire mouse genome has been sequenced, there remain challenges concerning the elucidation of particular complex and polymorphic genomic loci. In the murine Igh locus, different haplotypes exist in different inbred mouse strains. For example, the Ighb haplotype sequence of the Mouse Genome Project strain C57BL/6 differs considerably from the Igha haplotype of BALB/c, which has been widely used in the analyses of Ab responses. We have sequenced and annotated the 3′ half of the Igha locus of 129S1/SvImJ, covering the CH region and approximately half of the VH region. This sequence comprises 128 VH genes, of which 49 are judged to be functional. The comparison of the Igha sequence with the homologous Ighb region from C57BL/6 revealed two major expansions in the germline repertoire of Igha. In addition, we found smaller haplotype-specific differences like the duplication of five VH genes in the Igha locus. We generated a VH allele table by comparing the individual VH genes of both haplotypes. Surprisingly, the number and position of DH genes in the 129S1 strain differs not only from the sequence of C57BL/6 but also from the map published for BALB/c. Taken together, the contiguous genomic sequence of the 3′ part of the Igha locus allows a detailed view of the recent evolution of this highly dynamic locus in the mouse. PMID:17675503

Some practicable applications of quadtree data structures/representation in astronomy

NASA Technical Reports Server (NTRS)

Pasztor, L.

1992-01-01

Development of quadtree as hierarchical data structuring technique for representing spatial data (like points, regions, surfaces, lines, curves, volumes, etc.) has been motivated to a large extent by storage requirements of images, maps, and other multidimensional (spatially structured) data. For many spatial algorithms, time-efficiency of quadtrees in terms of execution may be as important as their space-efficiency concerning storage conditions. Briefly, the quadtree is a class of hierarchical data structures which is based on the recursive partition of a square region into quadrants and sub-quadrants until a predefined limit. Beyond the wide applicability of quadtrees in image processing, spatial information analysis, and building digital databases (processes becoming ordinary for the astronomical community), there may be numerous further applications in astronomy. Some of these practicable applications based on quadtree representation of astronomical data are presented and suggested for further considerations. Examples are shown for use of point as well as region quadtrees. Statistics of different leaf and non-leaf nodes (homogeneous and heterogeneous sub-quadrants respectively) at different levels may provide useful information on spatial structure of astronomical data in question. By altering the principle guiding the decomposition process, different types of spatial data may be focused on. Finally, a sampling method based on quadtree representation of an image is proposed which may prove to be efficient in the elaboration of sampling strategy in a region where observations were carried out previously either with different resolution or/and in different bands.

State of the dam at the Zeya hydroelectric station with consideration of the geodynamic effect

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marchuk, A.N.; Dudchenko, L.N.; Bolgov, V.V.

1995-11-01

The buttress dam of the Zeya hydroelectric station has already been operating successfully for 20 years under complex climatic, geological, and seismological conditions. Additional difficulties are created by some uncertainty of the interaction of the structure with the geological environment subjected to tectonic movements. The seismotectonic conditions of the region of the Zeya reservoir are determined by proximity to the boundary of two large structural zones with a different character of tectonic movements: regions of the uplift of the Tukuringra-Soktokhan Range and the downwarping Amur-Zeya Plateau. This boundary is represented by the Pkan fault located about 1 km from themore » dam on the downstream side.« less

Alexander von Humboldt's perceptions of colonial Spanish America.

PubMed

Rebok, Sandra

2009-01-01

This study presents an in-depth analysis of Alexander von Humboldt's descriptions and critical comments on the colonial society of the different regions he visited during his well-known expedition through the Americas (1799-1804). The criticisms of colonialism that he expressed, reflecting his personal convictions, have already been the focal point of many studies, but Humboldt also was able to offer a more differentiated assessment through comparisons of regional and local traditions and developments. This essay focuses on his personal diaries, which offer many interesting comments on colonial societies. These considerations and impressions made during the expedition are of particular scholarly value since they were not subject to censorship of any kind.

Effects of concentration on the microwave dielectric spectra of aqueous urea solutions

NASA Astrophysics Data System (ADS)

Lyashchenko, A. K.; Dunyashev, V. S.; Zasetsky, A. Yu.

2017-05-01

Several models of relaxation for the dielectric spectra of aqueous urea solutions in the microwave region are compared. The spectra are shown to contain two main Debye components arising from the rotational motions of urea and water molecules. Two essentially different concentration regions in urea solutions are identified. The first is characterized by a small increase in the mobility of water molecules (τ1 = 7.8 ps) and the existence of hydrated urea molecules (τ2 = 19 ps). Due to the aggregation of urea molecules, the relaxation times for the latter process grow considerably in highly concentrated solutions. At the same time, faster molecular motions (τ3 = 6 ps) are observed for water molecules.

Wound ballistics of injuries caused by handguns with different types of projectiles.

PubMed

von See, Constantin; Stuehmer, Alexander; Gellrich, Nils-Claudius; Blum, Katrin S; Bormann, Kai-Hendrik; Rücker, Martin

2009-07-01

There are considerable differences in the shape and composition of military and civilian projectiles. Five different projectiles with the same kinetic energy were fired into the heads of freshly sacrificed pigs (n=30) through the submental region in the occipital direction. Computed tomography (CT) and 3D face scans of the animal skulls were obtained before and after firing. The image data sets were fused and provided the basis for a quantitative analysis of destruction patterns. As a result of the destruction of the parietal bone at the potential exit site, there were significant volume difference between the Action 4 (6.45 +/- 3.42 ml) and the Hydra-Shok projectile (12.71 +/- 2.86 ml). The partial metal-jacketed projectile showed a minor increase in volume (4.89 +/- 1.47 ml) and a partial loss of soft projectile components. Radiology showed differences between the various projectiles in fragmentation and bone and soft-tissue destruction. Although the projectiles had the same kinetic energy, there were considerable differences in injury patterns between full metal-jacketed projectiles, which are the only projectiles permitted for military use under the Geneva Conventions, and the other investigated projectiles. These injuries present a major medical challenge to both first responders and surgeons.

Forensic Stable Isotope Biogeochemistry

NASA Astrophysics Data System (ADS)

Cerling, Thure E.; Barnette, Janet E.; Bowen, Gabriel J.; Chesson, Lesley A.; Ehleringer, James R.; Remien, Christopher H.; Shea, Patrick; Tipple, Brett J.; West, Jason B.

2016-06-01

Stable isotopes are being used for forensic science studies, with applications to both natural and manufactured products. In this review we discuss how scientific evidence can be used in the legal context and where the scientific progress of hypothesis revisions can be in tension with the legal expectations of widely used methods for measurements. Although this review is written in the context of US law, many of the considerations of scientific reproducibility and acceptance of relevant scientific data span other legal systems that might apply different legal principles and therefore reach different conclusions. Stable isotopes are used in legal situations for comparing samples for authenticity or evidentiary considerations, in understanding trade patterns of illegal materials, and in understanding the origins of unknown decedents. Isotope evidence is particularly useful when considered in the broad framework of physiochemical processes and in recognizing regional to global patterns found in many materials, including foods and food products, drugs, and humans. Stable isotopes considered in the larger spatial context add an important dimension to forensic science.

Acoustic performance of low pressure axial fan rotors with different blade chord length and radial load distribution

NASA Astrophysics Data System (ADS)

Carolus, Thomas

The paper examines the acoustic and aerodynamic performance of low-pressure axial fan rotors with a hub/tip ratio of 0.45. Six rotors were designed for the same working point by means of the well-known airfoil theory. The condition of an equilibrium between the static pressure gradient and the centrifugal forces is maintained. All rotors have unequally spaced blades to diminish tonal noise. The rotors are tested in a short cylindrical housing without guide vanes. All rotors show very similar flux-pressure difference characteristics. The peak efficiency and the noise performance is considerably influenced by the chosen blade design. The aerodynamically and acoustically optimal rotor is the one with the reduced load at the hub and increased load in the tip region under satisfied equilibrium conditions. It runs at the highest aerodynamic efficiency, and its noise spectrum is fairly smooth. The overall sound pressure level of this rotor is up to 8 dB (A) lower compared to the other rotors under consideration.

[Micro and Macro Social Work Practice in the Context of Tuberculosis].

PubMed

Moya, Eva M; Chavez-Baray, Silvia M; Martínez, Omar

2017-07-01

The study of tuberculosis (TB) in the U.S.-Mexico border involves the consideration of three key components, which are complex and interrelated: the difficulty tracking and providing appropriate TB care due to the epidemiological and pathological characteristics of TB; the border itself is a geographical and epidemiological area that interweaves two nations, two cultures, two health systems and different laws; and the need for prevention and treatment approaches to TB that involve comprehensive clinical care and prevention while also taking into consideration stigma, social context and knowledge. This manuscript describes the work of ten studies conducted in Mexico and in the U.S.-Mexico border region from 2006 to 2013. It also provides an understanding of the social and public health implications of TB, the environment and communities, as well as the identification and application of advocacy and social mobilization practices. The work presented provides an understanding of different interventions related to adherence, stigma reduction, person-centered approaches, and effective micro and macro practices in social work.

Justification of CT for Individual Health Assessment of Asymptomatic Persons: A World Health Organization Consultation.

PubMed

Malone, Jim; Del Rosario Perez, Maria; Friberg, Eva Godske; Prokop, Mathias; Jung, Seung Eun; Griebel, Jurgen; Ebdon-Jackson, Steve

2016-12-01

An international expert consultation was convened by the World Health Organization (WHO). The purpose of the meeting was to review the use of CT in examining asymptomatic people. This is often referred to as individual health assessment (IHA). IHA was identified as a global phenomenon unenthusiastically tolerated, and not actively promoted, structured, or regulated in most countries. This paper identifies the state of the art for IHA and some considerations in relation to its justification, in different regions of the world. The outcomes reached include the following: questions around terminology and culture of IHA practice; review of IHA in some countries, regions, and international bodies; dilemmas for participants in IHA; risk communication, education, and training for professions and public; the desirability of guidelines and clinical audit; social, ethical, public health, and resource considerations; and a framework for IHA and regulatory considerations. Three subcategories of examination for asymptomatic individuals were identified: formal screening programs; examinations for which the evidence base or risk profile is incomplete; and opportunistic examinations with little or no evidence or risk profile to suggest they have any merit. The latter challenges the justification principle of radiation protection. In addition, the issue of the costs, direct and indirect, associated with false positives and/or equivocal/incidental findings were highlighted. These and other considerations make it difficult to view some IHA as a bona fide medical activity. To allow it to be viewed as such requires that it be conducted within a robust clinical governance framework that includes regulatory dimensions. Copyright © 2016 The World Health Organization. Published by Elsevier Inc. All rights reserved.

Modelling the effects of trade-offs between long and short-term objectives in fisheries management.

PubMed

Mardle, Simon; Pascoe, Sean

2002-05-01

Fisheries management is typically a complex problem, from both an environmental and political perspective. The main source of conflict occurs between the need for stock conservation and the need for fishing community well-being, which is typically measured by employment and income levels. For most fisheries, overexploitation of the stock requires a reduction in the level of fishing activity. While this may lead to long-term benefits (both conservation and economic), it also leads to a short-term reduction in employment and regional incomes. In regions which are heavily dependent on fisheries, short-term consequences of conservation efforts may be considerable. The relatively high degree of scientific uncertainty with respect to the status of the stocks and the relatively short lengths of political terms of office, generally give rise to the short-run view taking the highest priority when defining policy objectives. In this paper, a multi-objective model of the North Sea is developed that incorporates both long-term and short-term objectives. Optimal fleet sizes are estimated taking into consideration different preferences between the defined short-term and long-term objectives. The subsequent results from the model give the short-term and long-term equilibrium status of the fishery incorporating the effects of the short-term objectives. As would be expected, an optimal fleet from a short-term perspective is considerably larger than an optimal fleet from a long-run perspective. Conversely, stock sizes and sustainable yields are considerably lower in the long-term if a short-term perspective is used in setting management policies. The model results highlight what is essentially a principal-agent problem, with the objectives of the policy makers not necessarily reflecting the objectives of society as a whole.

A note on a corrector formula for the numerical solution of ordinary differential equations

NASA Technical Reports Server (NTRS)

Chien, Y.-C.; Agrawal, K. M.

1979-01-01

A new corrector formula for predictor-corrector methods for numerical solutions of ordinary differential equations is presented. Two considerations for choosing corrector formulas are given: (1) the coefficient in the error term and (2) its stability properties. The graph of the roots of an equation plotted against its stability region, of different values, is presented along with the tables that correspond to various corrector equations, including Hamming's and Milne and Reynolds'.

[Fatty acids in confectionery products].

PubMed

Daniewski, M; Mielniczuk, E; Jacórzyński, B; Pawlicka, M; Balas, J; Filipek, A; Górnicka, M

2000-01-01

The content of fat and fatty acids in 144 different confectionery products purchased on the market in Warsaw region during 1997-1999 have been investigated. In examined confectionery products considerable variability of both fat and fatty acids content have been found. The content of fat varied from 6.6% (coconut cookies) up to 40% (chocolate wafers). Saturated fatty acids were present in both cis and trans form. Especially trans fatty acids reach (above 50%) were fats extracted from nut wafers, coconuts wafers.

Future Indonesia-East Timor Relations: An Analysis of the Regional Security Practices in the Cold War and After

DTIC Science & Technology

2001-06-01

reiteration of the most dominant feature of the post-Cold War global order the emergence of ethnic and religious issues as major themes of state and...security. Considerations such as historical roots and legacy, ethnic identities, civilization linkages, colonial experiences, geographic location, and...extremely complex in nature. A common phenomenon during the Cold War was the tendency of the armed forces to intervene when ethnic differences arose. Thus

Two new turrid species (Gastropoda: Pseudomelatomidae) from the Palawan region, the Philippines.

PubMed

Stahlschmidt, Peter; Fraussen, Koen

2014-03-26

Species richness of tropical marine molluscs is considerably underestimated (Bouchet et al. 2002). Indeed, the molluscan faunas of some regions, such as Palawan in the western Pacific, have received little attention and some hyper-diverse groups, such as the turrids (a parapyhletic group of Conoidea, formerly known as Turridae), are barely documented. For example, apart from original descriptions of two turrid taxa that have their type locations in Palawan (Comitas aequatorialis palawanica Powell, 1969 and Mangilia quadrasi Boettger, 1895 = Gingicithara notabilis (E. A. Smith, 1888)), there are no published records of turrids from this region. We have been fortunate to have access to recent collections of turrids from different parts of Palawan. Examination of these materials has revealed existence of several undescribed and potentially endemic species. In the present paper two new Pseudomelatomidae species are described.

A histomorphometric study of adaptive responses of cancellous bone in different regions in the sheep mandibular condyle following experimental forward mandibular displacement.

PubMed

Ma, Bingkui; Sampson, Wayne; Wilson, David; Wiebkin, Ole; Fazzalari, Nicola

2002-07-01

Forward mandibular displacement in animal models is associated with faster and/or redirected condylar growth. Here the effect of forward displacement induced with an intraoral appliance on modelling/remodelling of the mandibular condyle was investigated in eight, 4-month-old, castrated male Merino sheep, randomly allocated to experimental and control groups (n=4 in each group). The study period was 15 weeks, during that time, (1). calcein, (2). tetracycline, and (3). alizarin red S fluorochromes were given to all animals from day 1. Midsagittal sections of the temporomandibular joints were selected for analysis. Dynamic variables of bone formation, static indices of bone-forming and -resorbing activity, and structural indices of trabecular bone were estimated histomorphometrically. The sampling site was divided into two regions for analysis: (a). a 'subchondral region' (2 and 3 labels only), believed to be the bone newly formed during the experimental period; (b). a 'central region' (labelled by all three fluorochromes), believed to be the bone that existed before the experiment. Regional differences in adaptive response were found. In the experimental group, the bone-volume fraction (BV/TV) of the subchondral regions had decreased, although the specific bone-surface and bone-formation rates had increased. This low BV/TV was associated with decreased trabecular thickness and increased trabecular separation. In the central condylar region of the experimental group, BV/TV was unchanged, but an increased osteoid surface was apparent when the eroded surface was taken into consideration. These adaptive condylar responses to forward mandibular displacement appeared to be the result of increased osteoblastic activity. Further studies are recommended to examine why the subchondral and central regions responded differently.

Motorcycle emissions and fuel consumption in urban and rural driving conditions.

PubMed

Chen, K S; Wang, W C; Chen, H M; Lin, C F; Hsu, H C; Kao, J H; Hu, M T

2003-08-01

This work reports sampling of motorcycle on-road driving cycles in actual urban and rural environments and the development of representative driving cycles using the principle of least total variance in individual regions. Based on the representative driving cycles in individual regions, emission factors for carbon monoxide (CO), hydrocarbons (HC), nitrogen oxides (NO(x)=NO+NO(2)) and carbon dioxide (CO(2)), as well as fuel consumption, were determined using a chassis dynamometer. The measurement results show that the representative driving cycles are almost identical in the three largest cities in Taiwan, but they differ significantly from the rural driving cycle. Irrespective of driving conditions, emission factors differ insignificantly between the urban and rural regions at a 95% confidence level. However, the fuel consumption in urban centers is approximately 30% higher than in the rural regions, with driving conditions in the former usually poor compared to the latter. Two-stroke motorcycles generally have considerably higher HC emissions and quite lower NO(x) emissions than those of four-stroke motorcycles. Comparisons with other studies suggest that factors such as road characteristics, traffic volume, vehicle type, driving conditions and driver behavior may affect motorcycle emission levels in real traffic situations.

Large rainfall changes consistently projected over substantial areas of tropical land

NASA Astrophysics Data System (ADS)

Chadwick, Robin; Good, Peter; Martin, Gill; Rowell, David P.

2016-02-01

Many tropical countries are exceptionally vulnerable to changes in rainfall patterns, with floods or droughts often severely affecting human life and health, food and water supplies, ecosystems and infrastructure. There is widespread disagreement among climate model projections of how and where rainfall will change over tropical land at the regional scales relevant to impacts, with different models predicting the position of current tropical wet and dry regions to shift in different ways. Here we show that despite uncertainty in the location of future rainfall shifts, climate models consistently project that large rainfall changes will occur for a considerable proportion of tropical land over the twenty-first century. The area of semi-arid land affected by large changes under a higher emissions scenario is likely to be greater than during even the most extreme regional wet or dry periods of the twentieth century, such as the Sahel drought of the late 1960s to 1990s. Substantial changes are projected to occur by mid-century--earlier than previously expected--and to intensify in line with global temperature rise. Therefore, current climate projections contain quantitative, decision-relevant information on future regional rainfall changes, particularly with regard to climate change mitigation policy.

Individualized Prediction of Reading Comprehension Ability Using Gray Matter Volume.

PubMed

Cui, Zaixu; Su, Mengmeng; Li, Liangjie; Shu, Hua; Gong, Gaolang

2018-05-01

Reading comprehension is a crucial reading skill for learning and putatively contains 2 key components: reading decoding and linguistic comprehension. Current understanding of the neural mechanism underlying these reading comprehension components is lacking, and whether and how neuroanatomical features can be used to predict these 2 skills remain largely unexplored. In the present study, we analyzed a large sample from the Human Connectome Project (HCP) dataset and successfully built multivariate predictive models for these 2 skills using whole-brain gray matter volume features. The results showed that these models effectively captured individual differences in these 2 skills and were able to significantly predict these components of reading comprehension for unseen individuals. The strict cross-validation using the HCP cohort and another independent cohort of children demonstrated the model generalizability. The identified gray matter regions contributing to the skill prediction consisted of a wide range of regions covering the putative reading, cerebellum, and subcortical systems. Interestingly, there were gender differences in the predictive models, with the female-specific model overestimating the males' abilities. Moreover, the identified contributing gray matter regions for the female-specific and male-specific models exhibited considerable differences, supporting a gender-dependent neuroanatomical substrate for reading comprehension.

Comparative morphology of the scales of roundscale spearfish Tetrapturus georgii and white marlin Kajikia albida.

PubMed

Loose, E L; Hilton, E J; Graves, J E

2017-04-01

The comparative morphology of the scales of roundscale spearfish Tetrapturus georgii and white marlin Kajikia albida was investigated. In addition, variation in scale morphology across different body regions within each species was analysed. Although considerable morphological variation was observed among scales from different body regions in both species, scales of K. albida generally have pointed anterior ends, fewer posterior points and are more heavily imbricated than those of T. georgii, which are frequently rounded anteriorly, often have many posterior points and are separated farther within the skin. In all sampled body regions and individuals, scales of T. georgii are significantly broader and have a lower length-to-width aspect ratio than those of K. albida. Superficial to the scales are denticular plates, which are ossified formations occurring on the surface layer of the epidermis; these were observed and described for T. georgii, K. albida and blue marlin Makaira nigricans. Detailed scale descriptions allow for a more accurate characterization of the variation within and differences between these two species and could potentially be a valuable tool for investigating istiophorid systematics. © 2017 The Fisheries Society of the British Isles.

Infrared and infrared emission spectroscopic study of typical Chinese kaolinite and halloysite.

PubMed

Cheng, Hongfei; Frost, Ray L; Yang, Jing; Liu, Qinfu; He, Junkai

2010-12-01

The structure and thermal stability between typical Chinese kaolinite and halloysite were analysed by X-ray diffraction (XRD), infrared spectroscopy, infrared emission spectroscopy (IES) and Raman spectroscopy. Infrared emission spectroscopy over the temperature range of 300-700°C has been used to characterise the thermal decomposition of both kaolinite and halloysite. Halloysite is characterised by two bands in the water bending region at 1629 and 1648 cm(-1), attributed to structural water and coordinated water in the interlayer. Well defined hydroxyl stretching bands at around 3695, 3679, 3652 and 3625 cm(-1) are observed for both kaolinite and halloysite. The 550°C infrared emission spectrum of halloysite is similar to that of kaolinite in 650-1350 cm(-1) spectral region. The infrared emission spectra of halloysite were found to be considerably different to that of kaolinite at lower temperatures. These differences are attributed to the fundamental difference in the structure of the two minerals. Copyright © 2010 Elsevier B.V. All rights reserved.

Spatial variation in the climatic predictors of species compositional turnover and endemism.

PubMed

Di Virgilio, Giovanni; Laffan, Shawn W; Ebach, Malte C; Chapple, David G

2014-08-01

Previous research focusing on broad-scale or geographically invariant species-environment dependencies suggest that temperature-related variables explain more of the variation in reptile distributions than precipitation. However, species-environment relationships may exhibit considerable spatial variation contingent upon the geographic nuances that vary between locations. Broad-scale, geographically invariant analyses may mask this local variation and their findings may not generalize to different locations at local scales. We assess how reptile-climatic relationships change with varying spatial scale, location, and direction. Since the spatial distributions of diversity and endemism hotspots differ for other species groups, we also assess whether reptile species turnover and endemism hotspots are influenced differently by climatic predictors. Using New Zealand reptiles as an example, the variation in species turnover, endemism and turnover in climatic variables was measured using directional moving window analyses, rotated through 360°. Correlations between the species turnover, endemism and climatic turnover results generated by each rotation of the moving window were analysed using multivariate generalized linear models applied at national, regional, and local scales. At national-scale, temperature turnover consistently exhibited the greatest influence on species turnover and endemism, but model predictive capacity was low (typically r (2) = 0.05, P < 0.001). At regional scales the relative influence of temperature and precipitation turnover varied between regions, although model predictive capacity was also generally low. Climatic turnover was considerably more predictive of species turnover and endemism at local scales (e.g., r (2) = 0.65, P < 0.001). While temperature turnover had the greatest effect in one locale (the northern North Island), there was substantial variation in the relative influence of temperature and precipitation predictors in the remaining four locales. Species turnover and endemism hotspots often occurred in different locations. Climatic predictors had a smaller influence on endemism. Our results caution against assuming that variability in temperature will always be most predictive of reptile biodiversity across different spatial scales, locations and directions. The influence of climatic turnover on the species turnover and endemism of other taxa may exhibit similar patterns of spatial variation. Such intricate variation might be discerned more readily if studies at broad scales are complemented by geographically variant, local-scale analyses.

Worldwide Evaluations of Quinoa: Preliminary Results from Post International Year of Quinoa FAO Projects in Nine Countries.

PubMed

Bazile, Didier; Pulvento, Cataldo; Verniau, Alexis; Al-Nusairi, Mohammad S; Ba, Djibi; Breidy, Joelle; Hassan, Layth; Mohammed, Maarouf I; Mambetov, Omurbek; Otambekova, Munira; Sepahvand, Niaz Ali; Shams, Amr; Souici, Djamel; Miri, Khaled; Padulosi, Stefano

2016-01-01

Chenopodium quinoa Willd., a high quality grain crop, is resistant to abiotic stresses (drought, cold, and salt) and offers an optimal source of protein. Quinoa represents a symbol of crop genetic diversity across the Andean region. In recent years, this crop has undergone a major expansion outside its countries of origin. The activities carried out within the framework of the International Year of Quinoa provided a great contribution to raise awareness on the multiple benefits of quinoa as well as to its wider cultivation at the global level. FAO is actively involved in promoting and evaluating the cultivation of quinoa in 26 countries outside the Andean region with the aim to strengthen food and nutrition security. The main goal of this research is to evaluate the adaptability of selected quinoa genotypes under different environments outside the Andean region. This paper presents the preliminary results from nine countries. Field evaluations were conducted during 2013/2014 and 2014/2015 in Asia (Kyrgyzstan and Tajikistan), and the Near East and North African countries (Algeria, Egypt, Iraq, Iran, Lebanon, Mauritania, and Yemen). In each country, the trials were carried out in different locations that globally represent the diversity of 19 agrarian systems under different agro-ecological conditions. Twenty-one genotypes of quinoa were tested using the same experimental protocol in all locations consisting in a randomized complete block design (RCBD) with three replicates. Some genotypes showed higher yields and the Q18 and Q12 landraces displayed greater adaptation than others to new environmental conditions. The Q21 and Q26 landraces were evaluated with stable and satisfactory levels of yield (>1 t.ha(-1)) in each of the different trial sites. This production stability is of considerable importance especially under climate change uncertainty. While these results suggest that this Andean crop is able to grow in many different environments, social, and cultural considerations remain crucial regarding its possible introduction as a staple food in new cropping systems around the world.

Worldwide Evaluations of Quinoa: Preliminary Results from Post International Year of Quinoa FAO Projects in Nine Countries

PubMed Central

Bazile, Didier; Pulvento, Cataldo; Verniau, Alexis; Al-Nusairi, Mohammad S.; Ba, Djibi; Breidy, Joelle; Hassan, Layth; Mohammed, Maarouf I.; Mambetov, Omurbek; Otambekova, Munira; Sepahvand, Niaz Ali; Shams, Amr; Souici, Djamel; Miri, Khaled; Padulosi, Stefano

2016-01-01

Chenopodium quinoa Willd., a high quality grain crop, is resistant to abiotic stresses (drought, cold, and salt) and offers an optimal source of protein. Quinoa represents a symbol of crop genetic diversity across the Andean region. In recent years, this crop has undergone a major expansion outside its countries of origin. The activities carried out within the framework of the International Year of Quinoa provided a great contribution to raise awareness on the multiple benefits of quinoa as well as to its wider cultivation at the global level. FAO is actively involved in promoting and evaluating the cultivation of quinoa in 26 countries outside the Andean region with the aim to strengthen food and nutrition security. The main goal of this research is to evaluate the adaptability of selected quinoa genotypes under different environments outside the Andean region. This paper presents the preliminary results from nine countries. Field evaluations were conducted during 2013/2014 and 2014/2015 in Asia (Kyrgyzstan and Tajikistan), and the Near East and North African countries (Algeria, Egypt, Iraq, Iran, Lebanon, Mauritania, and Yemen). In each country, the trials were carried out in different locations that globally represent the diversity of 19 agrarian systems under different agro-ecological conditions. Twenty-one genotypes of quinoa were tested using the same experimental protocol in all locations consisting in a randomized complete block design (RCBD) with three replicates. Some genotypes showed higher yields and the Q18 and Q12 landraces displayed greater adaptation than others to new environmental conditions. The Q21 and Q26 landraces were evaluated with stable and satisfactory levels of yield (>1 t.ha−1) in each of the different trial sites. This production stability is of considerable importance especially under climate change uncertainty. While these results suggest that this Andean crop is able to grow in many different environments, social, and cultural considerations remain crucial regarding its possible introduction as a staple food in new cropping systems around the world. PMID:27446101

An exploration of multilevel modeling for estimating access to drinking-water and sanitation.

PubMed

Wolf, Jennyfer; Bonjour, Sophie; Prüss-Ustün, Annette

2013-03-01

Monitoring progress towards the targets for access to safe drinking-water and sanitation under the Millennium Development Goals (MDG) requires reliable estimates and indicators. We analyzed trends and reviewed current indicators used for those targets. We developed continuous time series for 1990 to 2015 for access to improved drinking-water sources and improved sanitation facilities by country using multilevel modeling (MLM). We show that MLM is a reliable and transparent tool with many advantages over alternative approaches to estimate access to facilities. Using current indicators, the MDG target for water would be met, but the target for sanitation missed considerably. The number of people without access to such services is still increasing in certain regions. Striking differences persist between urban and rural areas. Consideration of water quality and different classification of shared sanitation facilities would, however, alter estimates considerably. To achieve improved monitoring we propose: (1) considering the use of MLM as an alternative for estimating access to safe drinking-water and sanitation; (2) completing regular assessments of water quality and supporting the development of national regulatory frameworks as part of capacity development; (3) evaluating health impacts of shared sanitation; (4) using a more equitable presentation of countries' performances in providing improved services.

Mechanical properties of the cement of the stalked barnacle Dosima fascicularis (Cirripedia, Crustacea)

PubMed Central

Zheden, Vanessa; Klepal, Waltraud; Gorb, Stanislav N.; Kovalev, Alexander

2015-01-01

The stalked barnacle Dosima fascicularis secretes foam-like cement, the amount of which usually exceeds that produced by other barnacles. When Dosima settles on small objects, this adhesive is additionally used as a float which gives buoyancy to the animal. The dual use of the cement by D. fascicularis requires mechanical properties different from those of other barnacle species. In the float, two regions with different morphological structure and mechanical properties can be distinguished. The outer compact zone with small gas-filled bubbles (cells) is harder than the interior one and forms a protective rind presumably against mechanical damage. The inner region with large, gas-filled cells is soft. This study demonstrates that D. fascicularis cement is soft and visco-elastic. We show that the values of the elastic modulus, hardness and tensile stress are considerably lower than in the rigid cement of other barnacles. PMID:25657833

Thermochronologic constraints on the tectonic evolution of the western Antarctic Peninsula in late Mesozoic and Cenozoic times

USGS Publications Warehouse

Brix, M.R.; Faundez, V.; Hervé, F.; Solari, M.; Fernandez, J.; Carter, A.; Stöckhert, B.

2007-01-01

West of the Antarctic Peninsula, oceanic lithosphere of the Phoenix plate has been subducted below the Antarctic plate. Subduction has ceased successively from south to north over the last 65 Myr. An influence of this evolution on the segmentation of the crust in the Antarctic plate is disputed. Opposing scenarios consider effects of ridge crest – trench interactions with the subduction zone or differences in slip along a basal detachment in the overriding plate. Fission track (FT) analyses on apatites and zircons may detect thermochronologic patterns to test these hypotheses. While existing data concentrate on accretionary processes in Palmer Land, new data extend information to the northern part of the Antarctic Peninsula. Zircons from different geological units over wide areas of the Antarctic Peninsula yield fission track ages between 90 and 80 Ma, indicating a uniform regional cooling episode. Apatite FT ages obtained so far show considerable regional variability

Approaches to Establishing the Chemical Structure of Extraterrestrial Organic Solids

NASA Technical Reports Server (NTRS)

Cody, G. D.; Alexander, C. M. OD.; Wirick, Susan

2003-01-01

The majority of extraterrestrial organic matter in carbonaceous chondrites resides in a chemically complex, insoluble and perhaps macromolecular phase. We have been applying a series of independent solid state NMR experiments that are designed to provide a self consistent chemical characterization of this complex material. To date we have thoroughly analyzed 8 organic residues from different meteorites, including a CR2 (EET92042), CIl(Orgueil), CM2 (Murchison), Tagish Lake, CM2 (AlH83100), CM2 (Cold Bokkefeld), CM2 (Mighei), CM3 (Y86720). In fig 1. (1)H to (13)C cross polarization NMR spectra of four of these are shown. Note that there exists an enormous range in chemistry exhibited in organic solid [evident by the breadth of the spectral features both in the aliphatic region (sp(sup 3)) and the aromatic region (sp(sup 2))]. There is also considerable differences in the carbon chemistry across the meteorite groups.

Cloud and surface textural features in polar regions

NASA Technical Reports Server (NTRS)

Welch, Ronald M.; Kuo, Kwo-Sen; Sengupta, Sailes K.

1990-01-01

The study examines the textural signatures of clouds, ice-covered mountains, solid and broken sea ice and floes, and open water. The textural features are computed from sum and difference histogram and gray-level difference vector statistics defined at various pixel displacement distances derived from Landsat multispectral scanner data. Polar cloudiness, snow-covered mountainous regions, solid sea ice, glaciers, and open water have distinguishable texture features. This suggests that textural measures can be successfully applied to the detection of clouds over snow-covered mountains, an ability of considerable importance for the modeling of snow-melt runoff. However, broken stratocumulus cloud decks and thin cirrus over broken sea ice remain difficult to distinguish texturally. It is concluded that even with high spatial resolution imagery, it may not be possible to distinguish broken stratocumulus and thin clouds from sea ice in the marginal ice zone using the visible channel textural features alone.

The relevance of dengue virus genotypes surveillance at country level before vaccine approval

PubMed Central

Usme-Ciro, José A; Méndez, Jairo A; Laiton, Katherine D; Páez, Andrés

2014-01-01

Dengue is a major threat for public health in tropical and subtropical countries around the world. In the absence of a licensed vaccine and effective antiviral therapies, control measures have been based on education activities and vector elimination. Current efforts for developing a vaccine are both promising and troubling. At the advent of the introduction of a tetravalent dengue vaccine, molecular surveillance of the circulating genotypes in different geographical regions has gained considerable importance. A growing body of in vitro, preclinical, and clinical phase studies suggest that vaccine conferred protection in a geographical area could depends on the coincidence of the dengue virus genotypes included in the vaccine and those circulating. In this review we present the state-of-the-art in this field, highlighting the need of deeper knowledge on neutralizing immune response for making decisions about future vaccine approval and the potential need for different vaccine composition for regional administration. PMID:25483495

Differences in the emergent coding properties of cortical and striatal ensembles

PubMed Central

Ma, L.; Hyman, J.M.; Lindsay, A.J.; Phillips, A.G.; Seamans, J.K.

2016-01-01

The function of a given brain region is often defined by the coding properties of its individual neurons, yet how this information is combined at the ensemble level is an equally important consideration. In the present study, multiple neurons from the anterior cingulate cortex (ACC) and the dorsal striatum (DS) were recorded simultaneously as rats performed different sequences of the same three actions. Sequence and lever decoding was remarkably similar on a per-neuron basis in the two regions. At the ensemble level, sequence-specific representations in the DS appeared synchronously but transiently along with the representation of lever location, while these two streams of information appeared independently and asynchronously in the ACC. As a result the ACC achieved superior ensemble decoding accuracy overall. Thus, the manner in which information was combined across neurons in an ensemble determined the functional separation of the ACC and DS on this task. PMID:24974796

The Regional-Matrix Approach to the Training of Highly Qualified Personnel for the Sustainable Development of the Mining Region

NASA Astrophysics Data System (ADS)

Zhernov, Evgeny; Nehoda, Evgenia

2017-11-01

The state, regional and industry approaches to the problem of personnel training for building an innovative knowledge economy at all levels that ensures sustainable development of the region are analyzed in the article using the cases of the Kemerovo region and the coal industry. A new regional-matrix approach to the training of highly qualified personnel is proposed, which allows to link the training systems with the regional economic matrix "natural resources - cognitive resources" developed by the author. A special feature of the new approach is the consideration of objective conditions and contradictions of regional systems of personnel training, which have formed as part of economic systems of regions differ-entiated in the matrix. The methodology of the research is based on the statement about the interconnectivity of general and local knowledge, from which the understanding of the need for a combination of regional, indus-try and state approaches to personnel training is derived. A new form of representing such a combination is the proposed approach, which is based on matrix analysis. The results of the research can be implemented in the practice of modernization of professional education of workers in the coal industry of the natural resources extractive region.

7 CFR 1486.103 - Are regional projects possible under the program?

Code of Federal Regulations, 2010 CFR

2010-01-01

... consideration provided such projects target qualifying emerging markets in the specified region. CCC may consider activities which target qualified emerging markets in a specific region, but are conducted in a... MARKETS PROGRAM General Information § 1486.103 Are regional projects possible under the program? Projects...

Who gets dipyrone (metamizole) in Germany? Prescribing by age, sex and region.

PubMed

Hoffmann, F; Meinecke, P; Freitag, M H; Glaeske, G; Schulze, J; Schmiemann, G

2015-06-01

Metamizole (dipyrone) is an analgesic that has been the focus of considerable controversy regarding its safety. Because of potentially life-threatening blood disorders such as agranulocytosis, it has been withdrawn in many countries but not in Germany, where prescribing even increased over recent years. We aimed to evaluate prescribing of metamizole in Germany with respect to age, sex and regional variations. Using data of a statutory health insurance, we analysed a cohort of 1·7 million persons who were insured at least 1 day in each quarter of 2009. Outcome of interest was the outpatient prescription prevalence, for example the proportion of persons receiving at least one prescription of metamizole. A total of 6·8% received metamizole with a higher prescribing prevalence in females (7·8% vs. 6·0%). The prevalence increased with age up to 26·7% in persons ≥85 years (men: 21·1%; and women: 30·4%). We found large regional variations with higher prevalences in the northern part of Germany. Most of the prescriptions were issued by general practitioners (78·9%). 58·3% were liquid oral formulations with considerable regional variations ranging between 32·3% in Mecklenburg-West Pomerania and 67·3% in North Rhine-Westphalia. Overall, liquid oral forms are much more often prescribed in the western than in the eastern part of Germany. Metamizole - a drug with a relatively narrow indication - is often prescribed in Germany with relevant differences by age, sex and region. Qualitative studies should clarify reasons for this. Further quantitative research should investigate small-area variations, indications and treatment durations. © 2015 John Wiley & Sons Ltd.

Fragmentation of care and the use of head computed tomography in patients with ischemic stroke.

PubMed

Bekelis, Kimon; Roberts, David W; Zhou, Weiping; Skinner, Jonathan S

2014-05-01

Computed tomographic (CT) scans are central diagnostic tests for ischemic stroke. Their inefficient use is a negative quality measure tracked by the Centers for Medicare and Medicaid Services. We performed a retrospective analysis of Medicare fee-for-service claims data for adults admitted for ischemic stroke from 2008 to 2009, with 1-year follow-up. The outcome measures were risk-adjusted rates of high-intensity CT use (≥4 head CT scans) and risk- and price-adjusted Medicare expenditures in the year after admission. The average number of head CT scans in the year after admission, for the 327 521 study patients, was 1.94, whereas 11.9% had ≥4. Risk-adjusted rates of high-intensity CT use ranged from 4.6% (Napa, CA) to 20.0% (East Long Island, NY). These rates were 2.6% higher for blacks than for whites (95% confidence interval, 2.1%-3.1%), with considerable regional variation. Higher fragmentation of care (number of different doctors seen) was associated with high-intensity CT use. Patients living in the top quintile regions of fragmentation experienced a 5.9% higher rate of high-intensity CT use, with the lowest quintile as reference; the corresponding odds ratio was 1.77 (95% confidence interval, 1.71-1.83). Similarly, 1-year risk- and price-adjusted expenditures exhibited considerable regional variation, ranging from $31 175 (Salem, MA) to $61 895 (McAllen, TX). Regional rates of high-intensity CT scans were positively associated with 1-year expenditures (r=0.56; P<0.01). Rates of high-intensity CT use for patients with ischemic stroke reflect wide practice patterns across regions and races. Medicare expenditures parallel these disparities. Fragmentation of care is associated with high-intensity CT use. © 2014 American Heart Association, Inc.

[Network Analyses in Regional Health Care Research: Example of Dermatological Care in the Metropolitan Region of Hamburg].

PubMed

Augustin, J; Austermann, J; Erasmi, S

2016-10-18

Background: One of the overall objectives of the legislator is to ensure an overall "homogeneous", and easily accessible medical care for the population. The physician-patient ratio can be used to describe the regional health care situation. But this method does not provide information concerning the availability of, for instance, the nearest doctor. Therefore, further parameters such as accessibility must be taken into consideration. For this purpose, network analyses are an appropriate method. The objective of this study is to present methodological tools to evaluate the healthcare situation in the metropolitan region of Hamburg, primarily focusing on accessibility using dermatologists as an example. Methods: Analyzing data of 20 counties, the geographical distribution of N=357 dermatologists and the physician-patient ratio were calculated. In a second step, a network analysis regarding accessibility was performed. In order to calculate accessibility, address data (physicians) were transformed into coordinates, consisting of defined places (N=303) and restrictions (e. g. speed, turn restrictions) of the network. The calculation of population-based accessibility is based on grid cells for the population density. Results: Despite adequacy of the overall medical situation, differences in the availability of the nearest dermatologists in the metropolitan region are remarkable, particularly when use of public transport is taken into consideration. In some counties, over 60% of the population require at least one hour to get to the nearest dermatologist using public transportation. In rural regions within the metropolitan area are particularly affected. Conclusion: The network analysis has shown that the choice and availability of transportation in combination with the location (rural/urban) is essential for health care access. Especially elderly people in rural areas with restricted mobility are at a disadvantage. Therefore, modern health care approaches (e. g. telemedicine) are necessary to optimize the health care situation in rural areas. Network analyses can make a valuable methodological contribution to the analysis of regional health care disparities. © Georg Thieme Verlag KG Stuttgart · New York.

Pedunculopontine Nucleus Region Deep Brain Stimulation in Parkinson Disease: Surgical Techniques, Side Effects, and Postoperative Imaging

PubMed Central

Hamani, Clement; Lozano, Andres M.; Mazzone, Paolo A.M.; Moro, Elena; Hutchison, William; Silburn, Peter A.; Zrinzo, Ludvic; Alam, Mesbah; Goetz, Laurent; Pereira, Erlick; Rughani, Anand; Thevathasan, Wesley; Aziz, Tipu; Bloem, Bastiaan R.; Brown, Peter; Chabardes, Stephan; Coyne, Terry; Foote, Kelly; Garcia-Rill, Edgar; Hirsch, Etienne C.; Okun, Michael S.; Krauss, Joachim K.

2017-01-01

The pedunculopontine nucleus (PPN) region has received considerable attention in clinical studies as a target for deep brain stimulation (DBS) in Parkinson disease. These studies have yielded variable results with an overall impression of improvement in falls and freezing in many but not all patients treated. We evaluated the available data on the surgical anatomy and terminology of the PPN region in a companion paper. Here we focus on issues concerning surgical technique, imaging, and early side effects of surgery. The aim of this paper was to gain more insight into the reasoning for choosing specific techniques and to discuss short-comings of available studies. Our data demonstrate the wide range in almost all fields which were investigated. There are a number of important challenges to be resolved, such as identification of the optimal target, the choice of the surgical approach to optimize electrode placement, the impact on the outcome of specific surgical techniques, the reliability of intraoperative confirmation of the target, and methodological differences in postoperative validation of the electrode position. There is considerable variability both within and across groups, the overall experience with PPN DBS is still limited, and there is a lack of controlled trials. Despite these challenges, the procedure seems to provide benefit to selected patients and appears to be relatively safe. One important limitation in comparing studies from different centers and analyzing outcomes is the great variability in targeting and surgical techniques, as shown in our paper. The challenges we identified will be of relevance when designing future studies to better address several controversial issues. We hope that the data we accumulated may facilitate the development of surgical protocols for PPN DBS. PMID:27728909

CB1 Cannabinoid Receptor Expression in the Striatum: Association with Corticostriatal Circuits and Developmental Regulation

PubMed Central

Van Waes, Vincent; Beverley, Joel A.; Siman, Homayoun; Tseng, Kuei Y.; Steiner, Heinz

2012-01-01

Corticostriatal circuits mediate various aspects of goal-directed behavior and are critically important for basal ganglia-related disorders. Activity in these circuits is regulated by the endocannabinoid system via stimulation of CB1 cannabinoid receptors. CB1 receptors are highly expressed in projection neurons and select interneurons of the striatum, but expression levels vary considerably between different striatal regions (functional domains). We investigated CB1 receptor expression within specific corticostriatal circuits by mapping CB1 mRNA levels in striatal sectors defined by their cortical inputs in rats. We also assessed changes in CB1 expression in the striatum during development. Our results show that CB1 expression is highest in juveniles (P25) and then progressively decreases toward adolescent (P40) and adult (P70) levels. At every age, CB1 receptors are predominantly expressed in sensorimotor striatal sectors, with considerably lower expression in associative and limbic sectors. Moreover, for most corticostriatal circuits there is an inverse relationship between cortical and striatal expression levels. Thus, striatal sectors with high CB1 expression (sensorimotor sectors) tend to receive inputs from cortical areas with low expression, while striatal sectors with low expression (associative/limbic sectors) receive inputs from cortical regions with higher expression (medial prefrontal cortex). In so far as CB1 mRNA levels reflect receptor function, our findings suggest differential CB1 signaling between different developmental stages and between sensorimotor and associative/limbic circuits. The regional distribution of CB1 receptor expression in the striatum further suggests that, in sensorimotor sectors, CB1 receptors mostly regulate GABA inputs from local axon collaterals of projection neurons, whereas in associative/limbic sectors, CB1 regulation of GABA inputs from interneurons and glutamate inputs may be more important. PMID:22416230

Distribution of metal concentrations in sediments of the coastal zone of the Gulf of Riga and open part of the Baltic Sea

NASA Astrophysics Data System (ADS)

Seisuma, Z.; Kulikova, I.

2012-11-01

The comparison of spatial and temporal distribution of Hg, Cd, Pb, Cu, Ni, Zn, Mn and Fe concentrations in sediments from the Gulf of Riga and open Baltic Sea along the coastal zone is presented for the first time. There were considerable differences in Pb, Zn, Mn and Fe levels in sediment at various stations of the Gulf of Riga. A significant difference of Cd, Pb, Cu, Ni, Zn levels was found in sediments of various stations in the open Baltic coast. The amount of Cd, Pb, Cu, Ni, Zn and Fe levels also differed significantly in the sediments of the Gulf of Riga in different years. A considerable yearly difference in amount of Hg, Cd, Pb, Cu, Ni and Mn levels was found in sediments in the open Baltic coast. The essential highest values of Pb and Zn in coastal sediments of the open Baltic Sea are stated in comparison with the Gulf of Riga. The concentrations of other metals have only a tendency to be higher in coastal sediments of the open Baltic Sea in comparison with the Gulf of Riga. Natural and anthropogenic factors were proved to play an important role in determining resultant metals concentrations in the regions.

A site specific model and analysis of the neutral somatic mutation rate in whole-genome cancer data.

PubMed

Bertl, Johanna; Guo, Qianyun; Juul, Malene; Besenbacher, Søren; Nielsen, Morten Muhlig; Hornshøj, Henrik; Pedersen, Jakob Skou; Hobolth, Asger

2018-04-19

Detailed modelling of the neutral mutational process in cancer cells is crucial for identifying driver mutations and understanding the mutational mechanisms that act during cancer development. The neutral mutational process is very complex: whole-genome analyses have revealed that the mutation rate differs between cancer types, between patients and along the genome depending on the genetic and epigenetic context. Therefore, methods that predict the number of different types of mutations in regions or specific genomic elements must consider local genomic explanatory variables. A major drawback of most methods is the need to average the explanatory variables across the entire region or genomic element. This procedure is particularly problematic if the explanatory variable varies dramatically in the element under consideration. To take into account the fine scale of the explanatory variables, we model the probabilities of different types of mutations for each position in the genome by multinomial logistic regression. We analyse 505 cancer genomes from 14 different cancer types and compare the performance in predicting mutation rate for both regional based models and site-specific models. We show that for 1000 randomly selected genomic positions, the site-specific model predicts the mutation rate much better than regional based models. We use a forward selection procedure to identify the most important explanatory variables. The procedure identifies site-specific conservation (phyloP), replication timing, and expression level as the best predictors for the mutation rate. Finally, our model confirms and quantifies certain well-known mutational signatures. We find that our site-specific multinomial regression model outperforms the regional based models. The possibility of including genomic variables on different scales and patient specific variables makes it a versatile framework for studying different mutational mechanisms. Our model can serve as the neutral null model for the mutational process; regions that deviate from the null model are candidates for elements that drive cancer development.

Charging stations location model based on spatiotemporal electromobility use patterns

NASA Astrophysics Data System (ADS)

Pagany, Raphaela; Marquardt, Anna; Zink, Roland

2016-04-01

One of the major challenges for mainstream adoption of electric vehicles is the provision of infrastructure for charging the batteries of the vehicles. The charging stations must not only be located dense enough to allow users to complete their journeys, but the electric energy must also be provided from renewable sources in order to truly offer a transportation with less CO2 emissions. The examination of potential locations for the charging of electric vehicles can facilitate the adaption of electromobility and the integration of electronic vehicles in everyday life. A geographic information system (GIS) based model for optimal location of charging stations in a small and regional scale is presented. This considers parameters such as the forecast of electric vehicle use penetration, the relevant weight of diverse point of interests and the distance between parking area and destination for different vehicle users. In addition to the spatial scale the temporal modelling of the energy demand at the different charging locations has to be considerate. Depending on different user profiles (commuters, short haul drivers etc.) the frequency of charging vary during the day, the week and the year. In consequence, the spatiotemporal variability is a challenge for a reliable energy supply inside a decentralized renewable energy system. The presented model delivers on the one side the most adequate identified locations for charging stations and on the other side the interaction between energy supply and demand for electromobility under the consideration of temporal aspects. Using ESRI ArcGIS Desktop, first results for the case study region of Lower Bavaria are generated. The aim of the concept is to keep the model transferable to other regions and also open to integrate further and more detailed user profiles, derived from social studies about i.e. the daily behavior and the perception of electromobility in a next step.

National study of the impact of patient information and involvement in decision-making on immediate breast reconstruction rates.

PubMed

Frisell, A; Lagergren, J; de Boniface, J

2016-11-01

Reconstructive alternatives should be discussed with women facing mastectomy for breast cancer. These include immediate and delayed reconstruction, which both have inherent advantages and disadvantages. Immediate reconstruction rates vary considerably in Swedish healthcare regions, and the aim of the study was to analyse reasons for this disparity. All women who underwent mastectomy for primary breast cancer in Sweden in 2013 were included. Tumour data were retrieved from the Swedish National Breast Cancer Registry and from questionnaires regarding patient information and involvement in preoperative decision-making sent to women who were still alive in 2015. Of 2929 women who had undergone 2996 mastectomies, 2906 were still alive. The questionnaire response rate was 76·3 per cent. Immediate reconstruction rates varied regionally, between 3·0 and 26·4 per cent. Tumour characteristics impacted on reconstruction rates but did not explain regional differences. Patient participation in decision-making, availability of plastic surgery services and patient information, however, were independent predictors of immediate breast reconstruction, and varied significantly between regions. Even in younger patients with low-risk tumours, rates of patient information ranged between 34·3 and 83·3 per cent. Significant regional differences in immediate reconstruction rates were not explained by differences in tumour characteristics, but by disparities in patient information, availability of plastic surgery services and involvement in decision-making. © 2016 The Authors. BJS published by John Wiley & Sons Ltd on behalf of BJS Society Ltd.

Physical oceanography of continental shelves

DOE Office of Scientific and Technical Information (OSTI.GOV)

Allen, J.S.; Beardlsey, R.C.; Blanton, J.O.

Knowledge of the physical oceanography of continental shelves has increased tremendously in recent years, primarily as a result of new current and hydrographic measurements made in locations where no comparable measurements existed previously. In general, observations from geographically distinct continental shelves have shown that the nature of the flow may vary considerably from region to region. Although some characteristics, such as the response of currents to wind forcing, are common to many shelves, the relative importance of various physical processes in influencing the shelf flow field frequently is different. In the last several years, the scientific literature on shelf studiesmore » has expanded rapidly, with that for separate regions, to some extent, developing independently because of the variable role played by different physical effects. Consequently, it seems that a simultaneous review of progress in physical oceanographic research in different shelf regions would be especially useful at this time in order to help assess the overall progress in the field. This multi-author report has been compiled as a result. Included are sections on the physical oceanography of continental shelves, in or off of, the eastern Bering Sea, northern Gulf of Alaska, Pacific Northwest, southern California, west Florida, southeastern US, Middle Atlantic Bight, Georges Bank and Peru. These discussions clearly point to the diverse nature of the dominant physics in several of the regions, as well as to some of the dynamical features they share in common. 390 references, 23 figures.« less

Discriminating Mining Induced Seismicity from Natural Tectonic Earthquakes in the Wasatch Plateau Region of Central Utah

NASA Astrophysics Data System (ADS)

Stein, J. R.; Pankow, K. L.; Koper, K. D.; McCarter, M. K.

2014-12-01

On average, several hundred earthquakes are located each year within the Wasatch Plateau region of central Utah. This region includes the boundary between the relatively stable Colorado Plateau and the actively extending Basin and Range physiographic provinces. Earthquakes in this region tend to fall in the intermountain seismic belt (ISB), a continuous band of seismicity that extends from Montana to Arizona. While most of the earthquakes in the ISB are of tectonic origin, events in the Wasatch Plateau also include mining induced seismicity (MIS) from local underground coal mining operations. Using a catalog of 16,182 seismic events (-0.25 < M < 4.5) recorded from 1981 to 2011, we use double difference relocation and waveform cross correlation techniques to help discriminate between these two populations of events. Double difference relocation greatly improves the relative locations between the many events that occur in this area. From the relative relocations, spatial differences between event types are used to differentiate between shallow MIS and considerably deeper events associated with tectonic seismicity. Additionally, waveform cross-correlation is used to cluster events with similar waveforms—meaning that events in each cluster should have a similar source location and mechanism—in order to more finely group seismic events occurring in the Wasatch Plateau. The results of this study provide both an increased understanding of the influence mining induced seismicity has on the number of earthquakes detected within this region, as well as better constraints on the deeper tectonic structure.

Psychosocial determinants of premature cardiovascular mortality differences within Hungary.

PubMed

Kopp, Maria; Skrabski, Arpád; Szántó, Zsuzsa; Siegrist, Johannes

2006-09-01

The life expectancy gap between Central-Eastern European (CEE) countries, including Hungary, and Western Europe (WE) is mainly attributable to excess cardiovascular (CV) mortality in midlife. This study explores the contribution of socioeconomic, work related, psychosocial, and behavioural variables to explaining variations of middle aged male and female CV mortality across 150 sub-regions in Hungary. Cross sectional, ecological analyses. 150 sub-regions of Hungary. 12 643 people were interviewed in Hungarostudy 2002 survey, representing the Hungarian population according to sex, age, and sub-regions. Independent variables were income, education, control in work, job insecurity, weekend working hours, social support, depression, hostility, anomie, smoking, body mass index, and alcohol misuse. Gender specific standardised premature (45-64 years) total CV, ischaemic heart disease, and cerebrovascular mortality rates in 150 sub-regions of Hungary. Low education and income were the most important determinants of mid-aged CV mortality differences across sub-regions. High weekend workload, low social support at work, and low control at work account for a large part of variation in male premature CV mortality rates, whereas job insecurity, high weekend workload, and low control at work contribute most noticeably to variations in premature CV mortality rates among women. Low social support from friends, depression, anomie, hostility, alcohol misuse and cigarette smoking can also explain a considerable part of variations of premature CV mortality differences. Variations in middle aged CV mortality rates in a rapidly changing society in CEE are largely accounted for by distinct unfavourable working and other psychosocial stress conditions.

15 CFR 990.15 - Considerations to facilitate restoration.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OIL POLLUTION.... Regional restoration planning may consist of compiling databases that identify, on a regional or watershed...

15 CFR 990.15 - Considerations to facilitate restoration.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OIL POLLUTION.... Regional restoration planning may consist of compiling databases that identify, on a regional or watershed...

15 CFR 990.15 - Considerations to facilitate restoration.

Code of Federal Regulations, 2013 CFR

2013-01-01

... Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OIL POLLUTION.... Regional restoration planning may consist of compiling databases that identify, on a regional or watershed...

15 CFR 990.15 - Considerations to facilitate restoration.

Code of Federal Regulations, 2012 CFR

2012-01-01

... Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OIL POLLUTION.... Regional restoration planning may consist of compiling databases that identify, on a regional or watershed...

Factors affecting stream nutrient loads: A synthesis of regional SPARROW model results for the continental United States

USGS Publications Warehouse

Preston, Stephen D.; Alexander, Richard B.; Schwarz, Gregory E.; Crawford, Charles G.

2011-01-01

We compared the results of 12 recently calibrated regional SPARROW (SPAtially Referenced Regressions On Watershed attributes) models covering most of the continental United States to evaluate the consistency and regional differences in factors affecting stream nutrient loads. The models - 6 for total nitrogen and 6 for total phosphorus - all provide similar levels of prediction accuracy, but those for major river basins in the eastern half of the country were somewhat more accurate. The models simulate long-term mean annual stream nutrient loads as a function of a wide range of known sources and climatic (precipitation, temperature), landscape (e.g., soils, geology), and aquatic factors affecting nutrient fate and transport. The results confirm the dominant effects of urban and agricultural sources on stream nutrient loads nationally and regionally, but reveal considerable spatial variability in the specific types of sources that control water quality. These include regional differences in the relative importance of different types of urban (municipal and industrial point vs. diffuse urban runoff) and agriculture (crop cultivation vs. animal waste) sources, as well as the effects of atmospheric deposition, mining, and background (e.g., soil phosphorus) sources on stream nutrients. Overall, we found that the SPARROW model results provide a consistent set of information for identifying the major sources and environmental factors affecting nutrient fate and transport in United States watersheds at regional and subregional scales. ?? 2011 American Water Resources Association. This article is a U.S. Government work and is in the public domain in the USA.

The Multimodal Brain Tumor Image Segmentation Benchmark (BRATS).

PubMed

Menze, Bjoern H; Jakab, Andras; Bauer, Stefan; Kalpathy-Cramer, Jayashree; Farahani, Keyvan; Kirby, Justin; Burren, Yuliya; Porz, Nicole; Slotboom, Johannes; Wiest, Roland; Lanczi, Levente; Gerstner, Elizabeth; Weber, Marc-André; Arbel, Tal; Avants, Brian B; Ayache, Nicholas; Buendia, Patricia; Collins, D Louis; Cordier, Nicolas; Corso, Jason J; Criminisi, Antonio; Das, Tilak; Delingette, Hervé; Demiralp, Çağatay; Durst, Christopher R; Dojat, Michel; Doyle, Senan; Festa, Joana; Forbes, Florence; Geremia, Ezequiel; Glocker, Ben; Golland, Polina; Guo, Xiaotao; Hamamci, Andac; Iftekharuddin, Khan M; Jena, Raj; John, Nigel M; Konukoglu, Ender; Lashkari, Danial; Mariz, José Antonió; Meier, Raphael; Pereira, Sérgio; Precup, Doina; Price, Stephen J; Raviv, Tammy Riklin; Reza, Syed M S; Ryan, Michael; Sarikaya, Duygu; Schwartz, Lawrence; Shin, Hoo-Chang; Shotton, Jamie; Silva, Carlos A; Sousa, Nuno; Subbanna, Nagesh K; Szekely, Gabor; Taylor, Thomas J; Thomas, Owen M; Tustison, Nicholas J; Unal, Gozde; Vasseur, Flor; Wintermark, Max; Ye, Dong Hye; Zhao, Liang; Zhao, Binsheng; Zikic, Darko; Prastawa, Marcel; Reyes, Mauricio; Van Leemput, Koen

2015-10-01

In this paper we report the set-up and results of the Multimodal Brain Tumor Image Segmentation Benchmark (BRATS) organized in conjunction with the MICCAI 2012 and 2013 conferences. Twenty state-of-the-art tumor segmentation algorithms were applied to a set of 65 multi-contrast MR scans of low- and high-grade glioma patients-manually annotated by up to four raters-and to 65 comparable scans generated using tumor image simulation software. Quantitative evaluations revealed considerable disagreement between the human raters in segmenting various tumor sub-regions (Dice scores in the range 74%-85%), illustrating the difficulty of this task. We found that different algorithms worked best for different sub-regions (reaching performance comparable to human inter-rater variability), but that no single algorithm ranked in the top for all sub-regions simultaneously. Fusing several good algorithms using a hierarchical majority vote yielded segmentations that consistently ranked above all individual algorithms, indicating remaining opportunities for further methodological improvements. The BRATS image data and manual annotations continue to be publicly available through an online evaluation system as an ongoing benchmarking resource.

The Multimodal Brain Tumor Image Segmentation Benchmark (BRATS)

PubMed Central

Jakab, Andras; Bauer, Stefan; Kalpathy-Cramer, Jayashree; Farahani, Keyvan; Kirby, Justin; Burren, Yuliya; Porz, Nicole; Slotboom, Johannes; Wiest, Roland; Lanczi, Levente; Gerstner, Elizabeth; Weber, Marc-André; Arbel, Tal; Avants, Brian B.; Ayache, Nicholas; Buendia, Patricia; Collins, D. Louis; Cordier, Nicolas; Corso, Jason J.; Criminisi, Antonio; Das, Tilak; Delingette, Hervé; Demiralp, Çağatay; Durst, Christopher R.; Dojat, Michel; Doyle, Senan; Festa, Joana; Forbes, Florence; Geremia, Ezequiel; Glocker, Ben; Golland, Polina; Guo, Xiaotao; Hamamci, Andac; Iftekharuddin, Khan M.; Jena, Raj; John, Nigel M.; Konukoglu, Ender; Lashkari, Danial; Mariz, José António; Meier, Raphael; Pereira, Sérgio; Precup, Doina; Price, Stephen J.; Raviv, Tammy Riklin; Reza, Syed M. S.; Ryan, Michael; Sarikaya, Duygu; Schwartz, Lawrence; Shin, Hoo-Chang; Shotton, Jamie; Silva, Carlos A.; Sousa, Nuno; Subbanna, Nagesh K.; Szekely, Gabor; Taylor, Thomas J.; Thomas, Owen M.; Tustison, Nicholas J.; Unal, Gozde; Vasseur, Flor; Wintermark, Max; Ye, Dong Hye; Zhao, Liang; Zhao, Binsheng; Zikic, Darko; Prastawa, Marcel; Reyes, Mauricio; Van Leemput, Koen

2016-01-01

In this paper we report the set-up and results of the Multimodal Brain Tumor Image Segmentation Benchmark (BRATS) organized in conjunction with the MICCAI 2012 and 2013 conferences. Twenty state-of-the-art tumor segmentation algorithms were applied to a set of 65 multi-contrast MR scans of low- and high-grade glioma patients—manually annotated by up to four raters—and to 65 comparable scans generated using tumor image simulation software. Quantitative evaluations revealed considerable disagreement between the human raters in segmenting various tumor sub-regions (Dice scores in the range 74%–85%), illustrating the difficulty of this task. We found that different algorithms worked best for different sub-regions (reaching performance comparable to human inter-rater variability), but that no single algorithm ranked in the top for all sub-regions simultaneously. Fusing several good algorithms using a hierarchical majority vote yielded segmentations that consistently ranked above all individual algorithms, indicating remaining opportunities for further methodological improvements. The BRATS image data and manual annotations continue to be publicly available through an online evaluation system as an ongoing benchmarking resource. PMID:25494501

Qualitative criteria and thresholds for low noise asphalt mixture design

NASA Astrophysics Data System (ADS)

Vaitkus, A.; Andriejauskas, T.; Gražulytė, J.; Šernas, O.; Vorobjovas, V.; Kleizienė, R.

2018-05-01

Low noise asphalt pavements are cost efficient and cost effective alternative for road traffic noise mitigation comparing with noise barriers, façade insulation and other known noise mitigation measures. However, design of low noise asphalt mixtures strongly depends on climate and traffic peculiarities of different regions. Severe climate regions face problems related with short durability of low noise asphalt mixtures in terms of considerable negative impact of harsh climate conditions (frost-thaw, large temperature fluctuations, hydrological behaviour, etc.) and traffic (traffic loads, traffic volumes, studded tyres, etc.). Thus there is a need to find balance between mechanical and acoustical durability as well as to ensure adequate pavement skid resistance for road safety purposes. Paper presents analysis of the qualitative criteria and design parameters thresholds of low noise asphalt mixtures. Different asphalt mixture composition materials (grading, aggregate, binder, additives, etc.) and relevant asphalt layer properties (air void content, texture, evenness, degree of compaction, etc.) were investigated and assessed according their suitability for durable and effective low noise pavements. Paper concluded with the overview of requirements, qualitative criteria and thresholds for low noise asphalt mixture design for severe climate regions.

Comparison of main-shock and aftershock fragility curves developed for New Zealand and US buildings

USGS Publications Warehouse

Uma, S.R.; Ryu, H.; Luco, N.; Liel, A.B.; Raghunandan, M.

2011-01-01

Seismic risk assessment involves the development of fragility functions to express the relationship between ground motion intensity and damage potential. In evaluating the risk associated with the building inventory in a region, it is essential to capture 'actual' characteristics of the buildings and group them so that 'generic building types' can be generated for further analysis of their damage potential. Variations in building characteristics across regions/countries largely influence the resulting fragility functions, such that building models are unsuitable to be adopted for risk assessment in any other region where a different set of building is present. In this paper, for a given building type (represented in terms of height and structural system), typical New Zealand and US building models are considered to illustrate the differences in structural model parameters and their effects on resulting fragility functions for a set of main-shocks and aftershocks. From this study, the general conclusion is that the methodology and assumptions used to derive basic capacity curve parameters have a considerable influence on fragility curves.

Water resources vulnerability assessment in the Adriatic Sea region: the case of Corfu Island.

PubMed

Kanakoudis, Vasilis; Tsitsifli, Stavroula; Papadopoulou, Anastasia; Cencur Curk, Barbara; Karleusa, Barbara

2017-09-01

Cross-border water resources management and protection is a complicated task to achieve, lacking a common methodological framework. Especially in the Adriatic region, water used for drinking water supply purposes pass from many different countries, turning its management into a hard task to achieve. During the DRINKADRIA project, a common methodological framework has been developed, for efficient and effective cross-border water supply and resources management, taking into consideration different resources types (surface and groundwater) emphasizing in drinking water supply intake. The common methodology for water resources management is based on four pillars: climate characteristics and climate change, water resources availability, quality, and security. The present paper assesses both present and future vulnerability of water resources in the Adriatic region, with special focus on Corfu Island, Greece. The results showed that climate change is expected to impact negatively on water resources availability while at the same time, water demand is expected to increase. Water quality problems will be intensified especially due to land use changes and salt water intrusion. The analysis identified areas where water resources are more vulnerable, allowing decision makers develop management strategies.

MicroRaman Spectroscopy and Raman Imaging of Basal Cell Carcinoma

NASA Astrophysics Data System (ADS)

Short, M. A.; Zeng, H.; Lui, H.

2005-03-01

We have measured the Raman spectra of normal and cancerous skin tissues using a confocal microRaman spectrograph with a sub-micron spatial resolution. We found that the Raman spectrum of a cell nucleolus is different from the spectra measured outside the nucleolus and considerably different from those measured outside the nucleus. In addition, we found significant spectroscopic differences between normal and cancer-bearing sites in the dermis region. In order to utilize these differences for non-invasive skin cancer diagnosis, we have developed a Raman imaging system that clearly demonstrates the structure, location and distribution of cells in unstained skin biopsy samples. Our method is expected to be useful for the detection and characterization of skin cancer based on the known distinct cellular differences between normal and malignant skin.

Regional estimation of response routine parameters

NASA Astrophysics Data System (ADS)

Tøfte, Lena S.

2015-04-01

Reducing the number of calibration parameters is of a considerable advantage when area distributed hydrological models are to be calibrated, both due to equifinality and over-parameterization of the model in general, and for making the calibration process more efficient. A simple non-threshold response model for drainage in natural catchments based on among others Kirchner's article in WRR 2009 is implemented in the gridded hydrological model in the ENKI framework. This response model takes only the hydrogram into account; it has one state and two parameters, and is adapted to catchments that are dominated by terrain drainage. In former analyses of natural discharge series from a large number of catchments in different regions of Norway, we found that these response model parameters can be calculated from some known catchment characteristics, as catchment area and lake percentage, found in maps or data bases, meaning that the parameters can easily be found also for ungauged catchments. In the presented work from the EU project COMPLEX a large region in Mid-Norway containing 27 simulated catchments of different sizes and characteristics is calibrated. Results from two different calibration strategies are compared: 1) removing the response parameters from the calibration by calculating them in advance, based on the results from our former studies, and 2) including the response parameters in the calibration, both as maps with different values for each catchment, and as a constant number for the total region. The resulting simulation performances are compared and discussed.

The influence of geographic and climate factors on the timing of dengue epidemics in Perú, 1994-2008

PubMed Central

2011-01-01

Background Dengue fever is a mosquito-borne disease that affects between 50 and 100 million people each year. Increasing our understanding of the heterogeneous transmission patterns of dengue at different spatial scales could have considerable public health value by guiding intervention strategies. Methods Based on the weekly number of dengue cases in Perú by province, we investigated the association between dengue incidence during the period 1994-2008 and demographic and climate factors across geographic regions of the country. Results Our findings support the presence of significant differences in the timing of dengue epidemics between jungle and coastal regions, with differences significantly associated with the timing of the seasonal cycle of mean temperature. Conclusions Dengue is highly persistent in jungle areas of Perú where epidemics peak most frequently around March when rainfall is abundant. Differences in the timing of dengue epidemics in jungle and coastal regions are significantly associated with the seasonal temperature cycle. Our results suggest that dengue is frequently imported into coastal regions through infective sparks from endemic jungle areas and/or cities of other neighboring endemic countries, where propitious environmental conditions promote year-round mosquito breeding sites. If jungle endemic areas are responsible for multiple dengue introductions into coastal areas, our findings suggest that curtailing the transmission of dengue in these most persistent areas could lead to significant reductions in dengue incidence in coastal areas where dengue incidence typically reaches low levels during the dry season. PMID:21651779

Bacterial diversity of Taxus rhizosphere: culture-independent and culture-dependent approaches.

PubMed

Hao, Da Cheng; Ge, Guang Bo; Yang, Ling

2008-07-01

The regional variability of Taxus rhizosphere bacterial community composition and diversity was studied by comparative analysis of three large 16S rRNA gene clone libraries from the Taxus rhizosphere in different regions of China (subtropical and temperate regions). One hundred and forty-six clones were screened for three libraries. Phylogenetic analysis of 16S rRNA gene sequences demonstrated that the abundance of sequences affiliated with Gammaproteobacteria, Betaproteobacteria, and Actinobacteria was higher in the library from the T. xmedia rhizosphere of the temperate region compared with the subtropical Taxus mairei rhizosphere. On the other hand, Acidobacteria was more abundant in libraries from the subtropical Taxus mairei rhizosphere. Richness estimates and diversity indices of three libraries revealed major differences, indicating a higher richness in the Taxus rhizosphere bacterial communities of the subtropical region and considerable variability in the bacterial community composition within this region. By enrichment culture, a novel Actinobacteria strain DICP16 was isolated from the T. xmedia rhizosphere of the temperate region and was identified as Leifsonia shinshuensis sp. via 16S rRNA gene and gyrase B sequence analyses. DICP16 was able to remove the xylosyl group from 7-xylosyl-10-deacetylbaccatin III and 7-xylosyl-10-deacetylpaclitaxel, thereby making the xylosyltaxanes available as sources of 10-deacetylbaccatin III and the anticancer drug paclitaxel. Taken together, the present studies provide, for the first time, the knowledge of the biodiversity of microorganisms populating Taxus rhizospheres.

Evaluation of older Chinese people's macronutrient intake status: results from the China Health and Nutrition Survey.

PubMed

Xu, Xiaoyue; Byles, Julie E; Shi, Zumin; Hall, John J

2015-01-14

Little is known about the macronutrient intake status of older Chinese people. The present study evaluated the macronutrient intake status of older Chinese people (aged ≥ 60 years), investigated whether they had intake levels that met the Dietary Reference Intakes (DRI), and explored the associations between macronutrient intakes and age groups, sex, education levels, work status, BMI groups, urbanicity levels and four socio-economic regions of China (Northeast, East Coast, Central and Western). Dietary intake data of 2746 older Chinese with complete dietary intake data in the Longitudinal China Health and Nutrition Survey (2009 wave) carried out across four diverse regions were analysed. Dietary intake data were obtained by interviews using 24 h recalls over three consecutive days. The MUFA:SFA ratios were calculated based on the Chinese Food Composition Table. Less than one-third of the older Chinese people included in the present study had intake levels meeting the adequate intake for carbohydrate-energy and fat-energy; less than one-fifth had intake levels meeting the recommended nutrient intake for protein-energy; and more than half of the older people had fat-energy intakes higher than the DRI. There were strong associations between the proportions of energy from the three macronutrients and education levels, urbanicity levels and the four socio-economic regions of China, with older people living in the East Coast region having different patterns of macronutrient-energy intakes when compared with those living in the other three regions. Macronutrient intakes across different urbanicity levels in the four regions revealed considerable geographical variations in dietary patterns, which will affect the risk factors for non-communicable diseases. Clinical interventions and public health policies should recognise these regional differences in dietary patterns.

Contribution of the AIRS Shortwave Sounding Channels to Retrieval Accuracy

NASA Technical Reports Server (NTRS)

Susskind, Joel; Kouvaris, Louis

2006-01-01

AIRS contains 2376 high spectral resolution channels between 650/cm and 2665/cm, including channels in both the 15 micron (near 667/cm) and 4.2 micron (near 2400/cm) COP sounding bands. Use of temperature sounding channels in the 15 micron CO2 band has considerable heritage in infra-red remote sensing. Channels in the 4.2 micron CO2 band have potential advantages for temperature sounding purposes because they are essentially insensitive to absorption by water vapor and ozone, and also have considerably sharper lower tropospheric temperature sounding weighting functions than do the 15 micron temperature sounding channels. Potential drawbacks with regard to use of 4.2 micron channels arise from effects on the observed radiances of solar radiation reflected by the surface and clouds, as well as effects of non-local thermodynamic equilibrium on shortwave observations during the day. These are of no practical consequences, however, when properly accounted for. We show results of experiments performed utilizing different spectral regions of AIRS, conducted with the AIRS Science Team candidate Version 5 algorithm. Experiments were performed using temperature sounding channels within the entire AIRS spectral coverage, within only the spectral region 650/cm to 1614 /cm; and within only the spectral region 1000/cm-2665/cm. These show the relative importance of utilizing only 15 micron temperature sounding channels, only the 4.2 micron temperature sounding channels, and both, with regards to sounding accuracy. The spectral region 2380/cm to 2400/cm is shown to contribute significantly to improve sounding accuracy in the lower troposphere, both day and night.

Differences in Relative Levels of 88 microRNAs in Various Regions of the Normal Adult Human Brain.

PubMed

Filatova, Elena V; Alieva, Anelya; Shadrina, Maria I; Slominsky, Petr A

2017-08-16

Since the discovery of microRNAs (miRNAs) in the 1990s, our knowledge about their biology has grown considerably. The increasing number of studies addressing the role of miRNAs in development and in various diseases emphasizes the need for a comprehensive catalogue of accurate sequence, expression and conservation information regarding the large number of miRNAs proposed recently in all organs and tissues. The objective of this study was to provide data on the levels of miRNA expression in 15 tissues of the normal human brain. We conducted an analysis of the relative levels of 88 of the most abundantly expressed and best characterized miRNA derived postmortem from well-characterized samples of various regions of the brains from five normal individuals. The cluster analysis revealed some differences in the relative levels of these miRNAs among the brain regions studied. Such diversity can be explained by different functioning of these brain regions. We hope that the data from the current study are a resource that will be useful to our colleagues in this exciting field, as more hypotheses will be generated and tested with regard to small noncoding RNA in the human brain in healthy and disease states. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Ornithorhynchus anatinus (platypus) links the evolution of immunoglobulin genes in eutherian mammals and nonmammalian tetrapods.

PubMed

Zhao, Yaofeng; Cui, Huiting; Whittington, Camilla M; Wei, Zhiguo; Zhang, Xiaofeng; Zhang, Ziding; Yu, Li; Ren, Liming; Hu, Xiaoxiang; Zhang, Yaping; Hellman, Lars; Belov, Katherine; Li, Ning; Hammarström, Lennart

2009-09-01

The evolutionary origins of mammalian immunoglobulin H chain isotypes (IgM, IgD, IgG, IgE, and IgA) are still incompletely understood as these isotypes differ considerably in structure and number from their counterparts in nonmammalian tetrapods. We report in this study that the platypus (Ornithorhynchus anatinus) Ig H chain constant region gene locus contains eight Ig encoding genes, which are arranged in an mu-delta-omicron-gamma2-gamma1-alpha1-epsilon-alpha2 order, spanning a total of approximately 200 kb DNA, encoding six distinct isotypes. The omicron (omicron for Ornithorhynchus) gene encodes a novel Ig H chain isotype that consists of four constant region domains and a hinge, and is structurally different from any of the five known mammalian Ig classes. This gene is phylogenetically related to upsilon (epsilon) and gamma, and thus appears to be a structural intermediate between these two genes. The platypus delta gene encodes ten heavy chain constant region domains, lacks a hinge region and is similar to IgD in amphibians and fish, but strikingly different from that in eutherian mammals. The platypus Ig H chain isotype repertoire thus shows a unique combination of genes that share similarity both to those of nonmammalian tetrapods and eutherian animals and demonstrates how phylogenetically informative species can be used to reconstruct the evolutionary history of functionally important genes.

How will the tundra-taiga interface respond to climate change?

PubMed

Skre, Oddvar; Baxter, Robert; Crawford, Robert M M; Callaghan, Terry V; Fedorkov, Alexey

2002-08-01

The intuitive and logical answer to the question of how the tundra-taiga interface will react to global warming is that it should move north and this is mirrored by many models of potential treeline migration. Northward movement may be the eventual outcome if climatic warming persists over centuries or millennia. However, closer examination of the tundra-taiga interface across its circumpolar extent reveals a more complex situation. The regional climatic history of the tundra-taiga interface is highly varied, and consequently it is to be expected that the forest tundra boundary zone will respond differently to climate change depending on local variations in climate, evolutionary history, soil development, and hydrology. Investigations reveal considerable stability at present in the position of the treeline and while there may be a long-term advance northwards there are oceanic regions where climatic warming may result in a retreat southwards due to increased bog development. Reinforcing this trend is an increasing human impact, particularly in the forest tundra of Russia, which forces the limit of the forested areas southwards. Local variations will therefore require continued observation and research, as they will be of considerable importance economically as well as for ecology and conservation.

An Optimal Hierarchical Decision Model for a Regional Logistics Network with Environmental Impact Consideration

PubMed Central

Zhang, Dezhi; Li, Shuangyan

2014-01-01

This paper proposes a new model of simultaneous optimization of three-level logistics decisions, for logistics authorities, logistics operators, and logistics users, for regional logistics network with environmental impact consideration. The proposed model addresses the interaction among the three logistics players in a complete competitive logistics service market with CO2 emission charges. We also explicitly incorporate the impacts of the scale economics of the logistics park and the logistics users' demand elasticity into the model. The logistics authorities aim to maximize the total social welfare of the system, considering the demand of green logistics development by two different methods: optimal location of logistics nodes and charging a CO2 emission tax. Logistics operators are assumed to compete with logistics service fare and frequency, while logistics users minimize their own perceived logistics disutility given logistics operators' service fare and frequency. A heuristic algorithm based on the multinomial logit model is presented for the three-level decision model, and a numerical example is given to illustrate the above optimal model and its algorithm. The proposed model provides a useful tool for modeling competitive logistics services and evaluating logistics policies at the strategic level. PMID:24977209

An optimal hierarchical decision model for a regional logistics network with environmental impact consideration.

PubMed

Zhang, Dezhi; Li, Shuangyan; Qin, Jin

2014-01-01

This paper proposes a new model of simultaneous optimization of three-level logistics decisions, for logistics authorities, logistics operators, and logistics users, for regional logistics network with environmental impact consideration. The proposed model addresses the interaction among the three logistics players in a complete competitive logistics service market with CO2 emission charges. We also explicitly incorporate the impacts of the scale economics of the logistics park and the logistics users' demand elasticity into the model. The logistics authorities aim to maximize the total social welfare of the system, considering the demand of green logistics development by two different methods: optimal location of logistics nodes and charging a CO2 emission tax. Logistics operators are assumed to compete with logistics service fare and frequency, while logistics users minimize their own perceived logistics disutility given logistics operators' service fare and frequency. A heuristic algorithm based on the multinomial logit model is presented for the three-level decision model, and a numerical example is given to illustrate the above optimal model and its algorithm. The proposed model provides a useful tool for modeling competitive logistics services and evaluating logistics policies at the strategic level.

NOAA/NCEI/Regional Climate Services: Working with Partners and Stakeholders across a Wide Network

NASA Astrophysics Data System (ADS)

Mecray, E. L.

2015-12-01

Federal agencies all require plans to be prepared at the state level that outline the implementation of funding to address wildlife habitat, human health, transportation infrastructure, coastal zone management, environmental management, emergency management, and others. These plans are now requiring the consideration of changing climate conditions. So where does a state turn to discuss lessons learned, obtain tools and information to assess climate conditions, and to work with other states in their region? Regional networks and collaboratives are working to deliver this sector by sector. How do these networks work? Do they fit together in any way? What similarities and differences exist? Is anyone talking across these lines to find common climate information requirements? A sketch is forming that links these efforts, not by blending the sectors, but by finding the areas where coordination is critical, where information needs are common, and where delivery mechanisms can be streamlined. NOAA/National Centers for Environmental Information's Regional Climate Services Directors have been working at the interface of stakeholder-driven information delivery since 2010. This talk will outline the regional climate services delivery framework for the Eastern Region, with examples of regional products and information.

Glucose metabolism in different regions of the rat brain under hypokinetic stress influence

NASA Technical Reports Server (NTRS)

Konitzer, K.; Voigt, S.

1980-01-01

Glucose metabolism in rats kept under long term hypokinetic stress was studied in 7 brain regions. Determination was made of the regional levels of glucose, lactate, glutamate, glutamine, aspartate, gamma-aminobutyrate and the incorporation of C-14 from plasma glucose into these metabolites, in glycogen and protein. From the content and activity data the regional glucose flux was approximated quantitatively. Under normal conditions the activity gradient cortex and frontal pole cerebellum, thalamus and mesencephalon, hypothalamus and pons and medulla is identical with that of the regional blood supply (measured with I131 serum albumin as the blood marker). Within the first days of immobilization a functional hypoxia occurred in all brain regions and the utilization of cycle amino acids for protein synthesis was strongly diminished. After the first week of stress the capillary volumes of all regions increased, aerobic glucose metabolism was enhanced (factors 1.3 - 2.0) and the incorporation of glucose C-14 via cycle amino acids into protein was considerably potentiated. The metabolic parameters normalized between the 7th and 11th week of stress. Blood supply and metabolic rate increased most in the hypothalamus.

Patterned gradient surface for spontaneous droplet transportation and water collection: simulation and experiment

NASA Astrophysics Data System (ADS)

Tan, Xianhua; Zhu, Yiying; Shi, Tielin; Tang, Zirong; Liao, Guanglan

2016-11-01

We demonstrate spontaneous droplet transportation and water collection on wedge-shaped gradient surfaces consisting of alternating hydrophilic and hydrophobic regions. Droplets on the surfaces are modeled and simulated to analyze the Gibbs free energy and free energy gradient distributions. Big half-apex angle and great wettability difference result in considerable free energy gradient, corresponding to large driving force for spontaneous droplet transportation, thus causing the droplets to move towards the open end of the wedge-shaped hydrophilic regions, where the Gibbs free energy is low. Gradient surfaces are then fabricated and tested. Filmwise condensation begins on the hydrophilic regions, forming wedge-shaped tracks for water collection. Dropwise condensation occurs on the hydrophobic regions, where the droplet size distribution and departure diameters are controlled by the width of the regions. Condensate water from both the hydrophilic and hydrophobic regions are collected directionally to the open end of the wedge-shaped hydrophilic regions, agreeing with the simulations. Directional droplet transport and controllable departure diameters make the branched gradient surfaces more efficient than smooth surfaces for water collection, which proves that gradient surfaces are potential in water collection, microfluidic devices, anti-fogging and self-cleaning.

Effects of Fishing and Regional Species Pool on the Functional Diversity of Fish Communities

PubMed Central

Martins, Gustavo M.; Arenas, Francisco; Neto, Ana I.; Jenkins, Stuart R.

2012-01-01

The potential population and community level impacts of fishing have received considerable attention, but little is known about how fishing influences communities’ functional diversity at regional scales. We examined how estimates of functional diversity differed among 25 regions of variable richness and investigated the functional consequences of removing species targeted by commercial fisheries. Our study shows that fishing leads to substantial losses in functional diversity. The magnitude of such loss was, however, reduced in the more speciose regions. Moreover, the removal of commercially targeted species caused a much larger reduction in functional diversity than expected by random species deletions, which was a consequence of the selective nature of fishing for particular species traits. Results suggest that functional redundancy is spatially variable, that richer biotas provide some degree of insurance against the impact of fishing on communities’ functional diversity and that fishing predominantly selects for particular species traits. Understanding how fishing impacts community functional diversity is key to predict its effects for biodiversity as well as ecosystem functioning. PMID:22952950

Prevalence of myofascial trigger points in fibromyalgia: the overlap of two common problems.

PubMed

Ge, Hong-You

2010-10-01

With the objective evidence of their existence, myofascial trigger points (MTrPs) contribute to an increasing number of chronic regional and widespread pain conditions. The widespread spontaneous pain pattern in fibromyalgia (FM) is a summation of multiple regional pains due to active MTrPs. A regional pain in FM is from local active MTrPs and/or referred from remote active MTrPs. Positive tender points specified in FM are MTrPs, either active or latent. Manual stimulation of active MTrPs located in the muscles in different body regions completely reproduced overall spontaneous FM pain pattern. Active MTrPs as tonic peripheral nociceptive input contribute tremendously to the initiation and maintenance of central sensitization, to the impairment of descending inhibition, to the increased excitability of motor units, and to the induction of sympathetic hyperactivity observed in FM. The considerable overlap of MTrPs and FM in pain characteristics and pathophysiology suggests that FM pain is largely due to MTrPs.

Lake seasonality across the Tibetan Plateau and their varying relationship with regional mass changes and local hydrology

NASA Astrophysics Data System (ADS)

Lei, Yanbin; Yao, Tandong; Yang, Kun; Sheng, Yongwei; Kleinherenbrink, Marcel; Yi, Shuang; Bird, Broxton W.; Zhang, Xiaowen; Zhu, La; Zhang, Guoqing

2017-01-01

The recent growth and deepening of inland lakes in the Tibetan Plateau (TP) may be a salient indicator of the consequences of climate change. The seasonal dynamics of these lakes is poorly understood despite this being potentially crucial for disentangling contributions from glacier melt and precipitation, which are all sensitive to climate, to lake water budget. Using in situ observations, satellite altimetry and gravimetry data, we identified two patterns of lake level seasonality. In the central, northern, and northeastern TP, lake levels are characterized by considerable increases during warm seasons and decreases during cold seasons, which is consistent with regional mass changes related to monsoon precipitation and evaporation. In the northwestern TP, however, lake levels exhibit dramatic increases during both warm and cold seasons, which deviate from regional mass changes. This appears to be more connected with high spring snowfall and large summer glacier melt. The variable lake level response to different drivers indicates heterogeneous sensitivity to climate change between the northwestern TP and other regions.

Synthesis of Caffeine/Maleic Acid Co-crystal by Ultrasound-assisted Slurry Co-crystallization.

PubMed

Apshingekar, Prafulla P; Aher, Suyog; Kelly, Adrian L; Brown, Elaine C; Paradkar, Anant

2017-01-01

A green approach has been used for co-crystallization of noncongruent co-crystal pair of caffeine/maleic acid using water. Ultrasound is known to affect crystallization; hence, the effect of high power ultrasound on the ternary phase diagram has been investigated in detail using a slurry co-crystallization approach. A systematic investigation was performed to understand how the accelerated conditions during ultrasound-assisted co-crystallization will affect different regions of the ternary phase diagram. Application of ultrasound showed considerable effect on the ternary phase diagram, principally on caffeine/maleic acid 2:1 (disappeared) and 1:1 co-crystal (narrowed) regions. Also, the stability regions for pure caffeine and maleic acid in water were narrowed in the presence of ultrasound, expanding the solution region. The observed effect of ultrasound on the phase diagram was correlated with solubility of caffeine and maleic acid and stability of co-crystal forms in water. Copyright © 2016. Published by Elsevier Inc.

Effects of fishing and regional species pool on the functional diversity of fish communities.

PubMed

Martins, Gustavo M; Arenas, Francisco; Neto, Ana I; Jenkins, Stuart R

2012-01-01

The potential population and community level impacts of fishing have received considerable attention, but little is known about how fishing influences communities' functional diversity at regional scales. We examined how estimates of functional diversity differed among 25 regions of variable richness and investigated the functional consequences of removing species targeted by commercial fisheries. Our study shows that fishing leads to substantial losses in functional diversity. The magnitude of such loss was, however, reduced in the more speciose regions. Moreover, the removal of commercially targeted species caused a much larger reduction in functional diversity than expected by random species deletions, which was a consequence of the selective nature of fishing for particular species traits. Results suggest that functional redundancy is spatially variable, that richer biotas provide some degree of insurance against the impact of fishing on communities' functional diversity and that fishing predominantly selects for particular species traits. Understanding how fishing impacts community functional diversity is key to predict its effects for biodiversity as well as ecosystem functioning.

Considerations for Assessing the Appropriateness of High-Cost Pediatric Care in Low-Income Regions

PubMed Central

Argent, Andrew C.

2018-01-01

It may be difficult to predict the consequences of provision of high-cost pediatric care (HCC) in low- and middle-income countries (LMICs), and these consequences may be different to those experienced in high-income countries. An evaluation of the implications of HCC in LMICs must incorporate considerations of the specific context in that country (population age profile, profile of disease, resources available), likely costs of the HCC, likely benefits that can be gained versus the costs that will be incurred. Ideally, the process that is followed in decision making around HCC should be transparent and should involve the communities that will be most affected by those decisions. It is essential that the impacts of provision of HCC are carefully monitored so that informed decisions can be made about future provision medical interventions. PMID:29637061

Biodiversity hotspots house most undiscovered plant species.

PubMed

Joppa, Lucas N; Roberts, David L; Myers, Norman; Pimm, Stuart L

2011-08-09

For most organisms, the number of described species considerably underestimates how many exist. This is itself a problem and causes secondary complications given present high rates of species extinction. Known numbers of flowering plants form the basis of biodiversity "hotspots"--places where high levels of endemism and habitat loss coincide to produce high extinction rates. How different would conservation priorities be if the catalog were complete? Approximately 15% more species of flowering plant are likely still undiscovered. They are almost certainly rare, and depending on where they live, suffer high risks of extinction from habitat loss and global climate disruption. By using a model that incorporates taxonomic effort over time, regions predicted to contain large numbers of undiscovered species are already conservation priorities. Our results leave global conservation priorities more or less intact, but suggest considerably higher levels of species imperilment than previously acknowledged.

Assessing the sampling strategy in the Northwestern Mediterranean Sea

NASA Astrophysics Data System (ADS)

Margirier, Félix; Testor, Pierre; Bosse, Anthony; Heslop, Emma; L'Hévéder, Blandine; Arsouze, Thomas; Houpert, Loic; Mortier, Laurent

2017-04-01

The deployment of numerous autonomous platforms (gliders, argo floats, moorings) added to the repeated ship cruises in the Northwestern Mediterranean Sea account for a considerable data coverage of the area through the past 10 years. In this study, we analyse the in-situ observations' ability to assess for the changes in the Northwester Mediterranean basin water masses properties over time. Comparing the observed time series for the different regions and different water masses to that of a glider simulator in the NEMO-Med12 model, we estimate both the quality of the model and the skill of the in-situ observations in reproducing the evolution of the basin properties.

A regional peculiarity of the low-latitude lower ionosphere

NASA Astrophysics Data System (ADS)

Givishvili, G. V.; Afinogenov, Iu. A.

1985-02-01

Experiments performed with the Al method at frequencies of 2.0 and 2.8 MHz on the ship Akademik Kurchatov during March-June 1976 in the Indian Ocean (28 deg N to 18 deg S, 40-79 deg E) revealed an area (Persian Gulf, 28-24 deg N) with a highly unusual diurnal variation of the ionospheric absorption of radio waves. This peculiarity consisted in extremely small prenoon values of absorption; the difference between the prenoon values and the higher postnoon absorption values at the two frequencies used was considerably higher than the measurement error (+ or - 3 dB). It is suggested that this peculiarity was connected with anomalously high rates of recombination processes in the morning hours in the lower ionosphere in this region.

Sequence of the chloroplast 16S rRNA gene and its surrounding regions of Chlamydomonas reinhardii.

PubMed Central

Dron, M; Rahire, M; Rochaix, J D

1982-01-01

The sequence of a 2 kb DNA fragment containing the chloroplast 16S ribosomal RNA gene from Chlamydomonas reinhardii and its flanking regions has been determined. The algal 16S rRNA sequence (1475 nucleotides) and secondary structure are highly related to those found in bacteria and in the chloroplasts of higher plants. In contrast, the flanking regions are very different. In C. reinhardii the 16S rRNA gene is surrounded by AT rich segments of about 180 bases, which are followed by a long stretch of complementary bases separated from each other by 1833 nucleotides. It is likely that these structures play an important role in the folding and processing of the precursor of 16S rRNA. The primary and secondary structures of the binding sites of two ribosomal proteins in the 16SrRNAs of E. coli and C. reinhardii are considerably related. Images PMID:6296784

Improving the coordination of patients' medication management: a regional Finnish development project.

PubMed

Kivekäs, Eija; Luukkonen, Irmeli; Mykkänen, Juha; Saranto, Kaija

2014-01-01

In this paper, we present an overview of activities and results from a regional development project in Finland. The aim in this project was to analyze how healthcare providers produce and receive information on a patient's medication, and to identify opportunities to improve the quality, effectiveness, availability and collaboration of social and healthcare services in relation to medication information. The project focused on the most important points in patients' medication management such as home care and care transitions. In a regional development project, data was gathered by interviews and a multi professional workshop. The study revealed that medication information reached only some professionals and lay caregivers despite electronic patient record (EPR) systems and tools. Differences in work processes related to medication reconciliation and information management were discussed in the group meeting and were regarded as a considerable risk for patient safety.

Using LANDSAT digital data for estimating green biomass. [Throckmorton, Texas test site and Great Plans Corridor, US

NASA Technical Reports Server (NTRS)

Deering, D. W.; Haas, R. H. (Principal Investigator)

1980-01-01

The author has identified the following significant results. Relationships between the quantity of mixed prairie rangeland vegetation and LANDSAT MSS response were studied during four growing seasons at test sites throughout the United States Great Plans region. A LANDSAT derived parameter, the normalized difference was developed from theoretical considerations fro statistical estimation of the amount and seasonal condition of rangeland vegetation. This parameter was tested for application to local assessment of green forage biomass and regional monitoring of range feed conditions and drought. Results show that for grasslands in the Great Plains with near continuous vegetative cover and free of heavy brush and forbs, the LANDSAT digital data can provide a useful estimate of the quantity of green forage biomass (within 250 kg/ha), and at least five levels of pasture and range feed conditions can be adequately mapped for extended regions.

Overtone Mobility Spectrometry (Part 2): Theoretical Considerations of Resolving Power

PubMed Central

Valentine, Stephen J.; Stokes, Sarah T.; Kurulugama, Ruwan T.; Nachtigall, Fabiane M.; Clemmer, David E.

2009-01-01

The transport of ions through multiple drift regions is modeled in order to develop an equation that is useful for an understanding of the resolving power of an overtone mobility spectrometry (OMS) technique. It is found that resolving power is influenced by a number of experimental variables, including those that define ion mobility spectrometry (IMS) resolving power: drift field (E), drift region length (L), and buffer gas temperature (T). However, unlike IMS, the resolving power of OMS is also influenced by the number of drift regions (n), harmonic frequency value (m), and the phase number (ϕ) of the applied drift field. The OMS resolving power dependence upon the new OMS variables (n, m, and ϕ) scales differently than the square root dependence of the E, L, and T variables in IMS. The results provide insight about optimal instrumental design and operation. PMID:19230705

Upper mantle electrical conductivity for seven subcontinental regions of the Earth

USGS Publications Warehouse

Campbell, W.H.; Schiffmacher, E.R.

1988-01-01

Spherical harmonic analysis coefficients of the external and internal parts of the quiet-day geomagnetic field variations (Sq) separated for the 7 continental regions of the observatories have been used to determine conductivity profiles to depths of about 600 km by the Schmucker equivalent substitute conductor method. The profiles give evidence of increases in conductivity between about 150 and 350 km depth, then a general increase in conductivity thereafter. For South America we found a high conductivity at shallow depths. The European profile showed a highly conducting layer near 125 km. At the greater depths, Europe, Australia and South America had the lowest values of conductivity. North America and east Asia had intermediate values whereas the African and central Asian profiles both showed the conductivities rising rapidly beyond 450 km depth. The regional differences indicate that there may be considerable lateral heterogeneity of electrical conductivity in the Earth's upper mantle. -Authors

Analysis of the separated boundary layer flow on the surface and in the wake of blunt trailing edge airfoils

NASA Technical Reports Server (NTRS)

Goradia, S. H.; Mehta, J. M.; Shrewsbury, G. S.

1977-01-01

The viscous flow phenomena associated with sharp and blunt trailing edge airfoils were investigated. Experimental measurements were obtained for a 17 percent thick, high performance GAW-1 airfoil. Experimental measurements consist of velocity and static pressure profiles which were obtained by the use of forward and reverse total pressure probes and disc type static pressure probes over the surface and in the wake of sharp and blunt trailing edge airfoils. Measurements of the upper surface boundary layer were obtained in both the attached and separated flow regions. In addition, static pressure data were acquired, and skin friction on the airfoil upper surface was measured with a specially constructed device. Comparison of the viscous flow data with data previously obtained elsewhere indicates reasonable agreement in the attached flow region. In the separated flow region, considerable differences exist between these two sets of measurements.

A geographic information system screening tool to tackle diffuse pollution through the use of sustainable drainage systems.

PubMed

Todorovic, Zorica; Breton, Neil P

2014-01-01

Sustainable drainage systems (SUDS) offer many benefits that traditional solutions do not. Traditional approaches are unable to offer a solution to problems of flood management and water quality. Holistic consideration of the wide range of benefits from SUDS can result in advantages such as improved flood resilience and water quality enhancement through consideration of diffuse pollution sources. Using a geographical information system (GIS) approach, diffuse pollutant sources and opportunities for SUDS are easily identified. Consideration of potential SUDS locations results in source, site and regional controls, leading to improved water quality (to meet Water Framework Directive targets). The paper will discuss two different applications of the tool, the first of which is where the pollutant of interest is known. In this case the outputs of the tool highlight and isolate the areas contributing the pollutants and suggest the adequate SUDS measures to meet the required criteria. The second application is where the tool identifies likely pollutants at a receiving location, and SUDS measures are proposed to reduce pollution with assessed efficiencies.

4C-ker: A Method to Reproducibly Identify Genome-Wide Interactions Captured by 4C-Seq Experiments.

PubMed

Raviram, Ramya; Rocha, Pedro P; Müller, Christian L; Miraldi, Emily R; Badri, Sana; Fu, Yi; Swanzey, Emily; Proudhon, Charlotte; Snetkova, Valentina; Bonneau, Richard; Skok, Jane A

2016-03-01

4C-Seq has proven to be a powerful technique to identify genome-wide interactions with a single locus of interest (or "bait") that can be important for gene regulation. However, analysis of 4C-Seq data is complicated by the many biases inherent to the technique. An important consideration when dealing with 4C-Seq data is the differences in resolution of signal across the genome that result from differences in 3D distance separation from the bait. This leads to the highest signal in the region immediately surrounding the bait and increasingly lower signals in far-cis and trans. Another important aspect of 4C-Seq experiments is the resolution, which is greatly influenced by the choice of restriction enzyme and the frequency at which it can cut the genome. Thus, it is important that a 4C-Seq analysis method is flexible enough to analyze data generated using different enzymes and to identify interactions across the entire genome. Current methods for 4C-Seq analysis only identify interactions in regions near the bait or in regions located in far-cis and trans, but no method comprehensively analyzes 4C signals of different length scales. In addition, some methods also fail in experiments where chromatin fragments are generated using frequent cutter restriction enzymes. Here, we describe 4C-ker, a Hidden-Markov Model based pipeline that identifies regions throughout the genome that interact with the 4C bait locus. In addition, we incorporate methods for the identification of differential interactions in multiple 4C-seq datasets collected from different genotypes or experimental conditions. Adaptive window sizes are used to correct for differences in signal coverage in near-bait regions, far-cis and trans chromosomes. Using several datasets, we demonstrate that 4C-ker outperforms all existing 4C-Seq pipelines in its ability to reproducibly identify interaction domains at all genomic ranges with different resolution enzymes.

4C-ker: A Method to Reproducibly Identify Genome-Wide Interactions Captured by 4C-Seq Experiments

PubMed Central

Raviram, Ramya; Rocha, Pedro P.; Müller, Christian L.; Miraldi, Emily R.; Badri, Sana; Fu, Yi; Swanzey, Emily; Proudhon, Charlotte; Snetkova, Valentina

2016-01-01

4C-Seq has proven to be a powerful technique to identify genome-wide interactions with a single locus of interest (or “bait”) that can be important for gene regulation. However, analysis of 4C-Seq data is complicated by the many biases inherent to the technique. An important consideration when dealing with 4C-Seq data is the differences in resolution of signal across the genome that result from differences in 3D distance separation from the bait. This leads to the highest signal in the region immediately surrounding the bait and increasingly lower signals in far-cis and trans. Another important aspect of 4C-Seq experiments is the resolution, which is greatly influenced by the choice of restriction enzyme and the frequency at which it can cut the genome. Thus, it is important that a 4C-Seq analysis method is flexible enough to analyze data generated using different enzymes and to identify interactions across the entire genome. Current methods for 4C-Seq analysis only identify interactions in regions near the bait or in regions located in far-cis and trans, but no method comprehensively analyzes 4C signals of different length scales. In addition, some methods also fail in experiments where chromatin fragments are generated using frequent cutter restriction enzymes. Here, we describe 4C-ker, a Hidden-Markov Model based pipeline that identifies regions throughout the genome that interact with the 4C bait locus. In addition, we incorporate methods for the identification of differential interactions in multiple 4C-seq datasets collected from different genotypes or experimental conditions. Adaptive window sizes are used to correct for differences in signal coverage in near-bait regions, far-cis and trans chromosomes. Using several datasets, we demonstrate that 4C-ker outperforms all existing 4C-Seq pipelines in its ability to reproducibly identify interaction domains at all genomic ranges with different resolution enzymes. PMID:26938081

Efficient computation of turbulent flow in ribbed passages using a non-overlapping near-wall domain decomposition method

NASA Astrophysics Data System (ADS)

Jones, Adam; Utyuzhnikov, Sergey

2017-08-01

Turbulent flow in a ribbed channel is studied using an efficient near-wall domain decomposition (NDD) method. The NDD approach is formulated by splitting the computational domain into an inner and outer region, with an interface boundary between the two. The computational mesh covers the outer region, and the flow in this region is solved using the open-source CFD code Code_Saturne with special boundary conditions on the interface boundary, called interface boundary conditions (IBCs). The IBCs are of Robin type and incorporate the effect of the inner region on the flow in the outer region. IBCs are formulated in terms of the distance from the interface boundary to the wall in the inner region. It is demonstrated that up to 90% of the region between the ribs in the ribbed passage can be removed from the computational mesh with an error on the friction factor within 2.5%. In addition, computations with NDD are faster than computations based on low Reynolds number (LRN) models by a factor of five. Different rib heights can be studied with the same mesh in the outer region without affecting the accuracy of the friction factor. This is tested with six different rib heights in an example of a design optimisation study. It is found that the friction factors computed with NDD are almost identical to the fully-resolved results. When used for inverse problems, NDD is considerably more efficient than LRN computations because only one computation needs to be performed and only one mesh needs to be generated.

Relationships between meiofaunal biodiversity and prokaryotic heterotrophic production in different tropical habitats and oceanic regions.

PubMed

Pusceddu, Antonio; Gambi, Cristina; Corinaldesi, Cinzia; Scopa, Mariaspina; Danovaro, Roberto

2014-01-01

Tropical marine ecosystems are among the most diverse of the world oceans, so that assessing the linkages between biodiversity and ecosystem functions (BEF) is a crucial step to predict consequences of biodiversity loss. Most BEF studies in marine ecosystems have been carried out on macrobenthic diversity, whereas the influence of the meiofauna on ecosystem functioning has received much less attention. We compared meiofaunal and nematode biodiversity and prokaryotic heterotrophic production across seagrass, mangrove and reef sediments in the Caribbean, Celebes and Red Seas. For all variables we report the presence of differences among habitats within the same region, and among regions within the same habitat. In all regions, the richness of meiofaunal taxa in reef and seagrass sediments is higher than in mangrove sediments. The sediments of the Celebes Sea show the highest meiofaunal biodiversity. The composition of meiofaunal assemblages varies significantly among habitats in the same region. The nematode beta diversity among habitats within the same region is higher than the beta diversity among regions. Although one site per habitat was considered in each region, these results suggest that the composition of meiofaunal assemblages varies primarily among biogeographic regions, whereas the composition of nematode assemblages varies more considerably among habitats. Meiofauna and nematode biodiversity and prokaryotic heterotrophic production, even after the removal of covariate effects linked with longitude and the quantity and nutritional quality of organic matter, are positively and linearly linked both across regions and within each habitat type. Our results confirm that meiofauna and nematode biodiversity may influence benthic prokaryotic activity, which, in turn, implies that diversity loss could have negative impacts on ecosystem functioning in these systems.

ITS all right mama: investigating the formation of chimeric sequences in the ITS2 region by DNA metabarcoding analyses of fungal mock communities of different complexities.

PubMed

Bjørnsgaard Aas, Anders; Davey, Marie Louise; Kauserud, Håvard

2017-07-01

The formation of chimeric sequences can create significant methodological bias in PCR-based DNA metabarcoding analyses. During mixed-template amplification of barcoding regions, chimera formation is frequent and well documented. However, profiling of fungal communities typically uses the more variable rDNA region ITS. Due to a larger research community, tools for chimera detection have been developed mainly for the 16S/18S markers. However, these tools are widely applied to the ITS region without verification of their performance. We examined the rate of chimera formation during amplification and 454 sequencing of the ITS2 region from fungal mock communities of different complexities. We evaluated the chimera detecting ability of two common chimera-checking algorithms: perseus and uchime. Large proportions of the chimeras reported were false positives. No false negatives were found in the data set. Verified chimeras accounted for only 0.2% of the total ITS2 reads, which is considerably less than what is typically reported in 16S and 18S metabarcoding analyses. Verified chimeric 'parent sequences' had significantly higher per cent identity to one another than to random members of the mock communities. Community complexity increased the rate of chimera formation. GC content was higher around the verified chimeric break points, potentially facilitating chimera formation through base pair mismatching in the neighbouring regions of high similarity in the chimeric region. We conclude that the hypervariable nature of the ITS region seems to buffer the rate of chimera formation in comparison with other, less variable barcoding regions, due to shorter regions of high sequence similarity. © 2016 John Wiley & Sons Ltd.

[Susceptibility and resistence of Pseudomonas aeruginosa to antimicrobial agents].

PubMed

Gamero Delgado, M C; García-Mayorgas, A D; Rodríguez, F; Ibarra, A; Casal, M

2007-06-01

Pseudomonas aeruginosa is an opportunistic microorganism that is frequently the cause of nosocomial infections. Multiple mechanisms are involved in its natural and acquired resistance to many of the antimicrobial agents commonly used in clinical practice. The objective of this study was to assess the susceptibility and resistance patterns of P. aeruginosa strains isolated in Hospital Reina Sofia between 2000 and 2005, as well as to analyze the differences between intrahospital and extrahospital isolates in 2005 and to compare the results with those obtained in other studies. A total of 3,019 strains of P. aeruginosa from different hospitals and nonhospital settings were evaluated, taking into consideration their degree of sensitivity to different antibiotics. The MICs were determined by means of the Wider I automated system (Soria Melguizo), taking into consideration the criteria of susceptibility and resistance recommended by MENSURA. Results of the analysis showed that P. aeruginosa maintained similar levels of antimicrobial susceptibility during the period 2000-2005, with increased susceptibility to amikacin, gentamicin and tobramycin. There were also important differences in the degree of susceptibility between intrahospital and extrahospital strains, except for imipenem and fosfomycin. The intrahospital difference in susceptibility was also evaluated, emphasizing the importance of periodically studying susceptibility and resistance patterns of P. aeruginosa in each setting in order to evaluate different therapeutic guidelines, as it is not always advisable to extrapolate data from different regions. These differences can be explained by the different use of antibiotics in each center and the geographic variations of the resistance mechanisms of P. aeruginosa.

High-throughput sequencing for the detection of the bacterial and fungal diversity in Mongolian naturally fermented cow's milk in Russia.

PubMed

Liu, Wenjun; Zheng, Yi; Kwok, Lai-Yu; Sun, Zhihong; Zhang, Jiachao; Guo, Zhuang; Hou, Qiangchuan; Menhe, Bilige; Zhang, Heping

2015-02-22

Traditional fermented dairy products are major components of the typical Mongolian diet since ancient times. However, almost all the previous studies on the microbial composition of traditional Mongolian fermented dairy products analyzed food samples from the Chinese Mongolian region and Mongolia but not the Russian Mongolian region. In this study, the bacterial and fungal community diversity of nineteen naturally fermented cow's milk (NFCM) samples from local Mongolian families residing in Kalmykia and Chita of Russia was investigated with pyrosequencing. Firmicutes and Ascomycota were the predominant phyla respectively for bacteria and fungi. The abundance of the bacterial phylum Acidobacteria was considerably different between the samples from the two regions. At genus level, Lactobacillus and Pichia were the predominating bacterial and fungal genera, respectively, while six bacterial genera significantly differed between the Kalmykia (enrichment of Aeromonas, Bacillus, Clostridium, Streptococcus, Vogesella) and Chita (enrichment of Lactococcus) samples. The results of principal coordinate analysis (PCoA) based on the bacterial or fungal composition of the Kalmykia and Chita samples revealed a different microbiota structure between the samples collected in these two locations. The redundancy analysis (RDA) identified 60 bacterial and 21 fungal OTUs as the key variables responsible for such microbiota structural difference. Our results suggest that structural differences existed in the microbiota of NFCM between Kalmykia and Chita. The difference in geographic environment may be an important factor influencing the microbial diversity of NFCM made by the Mongolians in Russia.

[Regional asymmetries. What are the differences in lifestyles and life satisfaction among adolescents? A study of students of the 3rd cycle of basic education in Portugal].

PubMed

Vieira, Tiago Paupério Ferreira; Alves, Nuno José Corte-Real Correia; Dias, Cláudia Salomé Lima; Da Fonseca, António Manuel Leal Ferreira Mendonça

2015-01-01

Based on the importance of behavior and life satisfaction for the health of young people and the considerable regional differences that exist in mainland Portugal, an investigation was conducted. It sought to verify differences in levels of the practice of sport, tobacco and alcohol consumption and life satisfaction among students of the 3rd cycle of basic education living in different inland/coastal and rural/urban areas. The sample consisted of 5624 adolescents, aged between 12 and 17 years. The instrument used for data collection was the "Inventory of Health-Related Behavior of Adolescents" and a translated version of "The Satisfaction With Life Scale". The results revealed that there are higher levels of smoking among young people living in urban and inland areas, higher levels of alcohol consumption among young people living in rural and inland areas and higher levels of life satisfaction among adolescents living in urban and coastal areas. Levels of sport were identical in all geographical areas. It was also found that there were significant differences in all variables of the analysis.

Morphological Integration of the Human Pelvis with Respect to Age and Sex.

PubMed

Mallard, Angela M; Savell, Kristen R R; Auerbach, Benjamin M

2017-04-01

Considerable research has shown that modern human pelvic dimensions, especially of the birth canal, are sexually dimorphic. Studies also suggest that females with younger ages-at-death have narrower canal dimensions than those who die at older ages, possibly due to continued independent growth of the pubis. A recent examination of this pattern argued that it is unlikely that these differences relate to mortality, but the source of the difference in pelvic dimensions with age remains unresolved. We use pelvic dimensions to assess differences in magnitudes of morphological integration between adult females and males across ages-at-death. We first ascertain whether the sexes have different strengths of integration, and then assess if differences in magnitudes of integration are associated with age-at-death. Pelvic dimensions of all groups were moderately integrated. Females and males have similar magnitudes of integration, and there is no change in the strength of integration with age. Examining individual regions of the pelvis indicates that the ilium, pubis, and pelvic inlet and outlet have stronger integration than the overall pelvis. This was particularly true of the pelvic outlet, which demonstrated the strongest integration. Our findings suggest that regions of the pelvis are more strongly integrated internally, and less integrated with each other, which would allow for proportional growth among regions of the pelvis with age that do not affect its overall integration. No single region of the pelvis appears to be motivating the difference in pelvic dimensions between age groups. We further consider the implications of these findings on evolutionary constraints. Anat Rec, 300:666-674, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Effects of packaging and heat transfer kinetics on drug-product stability during storage under uncontrolled temperature conditions.

PubMed

Nakamura, Toru; Yamaji, Takayuki; Takayama, Kozo

2013-05-01

To predict the stability of pharmaceutical preparations under uncontrolled temperature conditions accurately, a method to compute the average reaction rate constant taking into account the heat transfer from the atmosphere to the product was developed. The average reaction rate constants computed with taken into consideration heat transfer (κ(re) ) were then compared with those computed without taking heat transfer into consideration (κ(in) ). The apparent thermal diffusivity (κ(a) ) exerted some influence on the average reaction rate constant ratio (R, R = κ(re) /κ(in) ). In the regions where the κ(a) was large (above 1 h(-1) ) or very small, the value of R was close to 1. On the contrary, in the middle region (0.001-1 h(-1) ), the value of R was less than 1.The κ(a) of the central part of a large-size container and that of the central part of a paper case of 10 bottles of liquid medicine (100 mL) fell within this middle region. On the basis of the above-mentioned considerations, heat transfer may need to be taken into consideration to enable a more accurate prediction of the stability of actual pharmaceutical preparations under nonisothermal atmospheres. Copyright © 2013 Wiley Periodicals, Inc.

Analysis of the Nonlinear Trends and Non-Stationary Oscillations of Regional Precipitation in Xinjiang, Northwestern China, Using Ensemble Empirical Mode Decomposition

PubMed Central

Guo, Bin; Chen, Zhongsheng; Guo, Jinyun; Liu, Feng; Chen, Chuanfa; Liu, Kangli

2016-01-01

Changes in precipitation could have crucial influences on the regional water resources in arid regions such as Xinjiang. It is necessary to understand the intrinsic multi-scale variations of precipitation in different parts of Xinjiang in the context of climate change. In this study, based on precipitation data from 53 meteorological stations in Xinjiang during 1960–2012, we investigated the intrinsic multi-scale characteristics of precipitation variability using an adaptive method named ensemble empirical mode decomposition (EEMD). Obvious non-linear upward trends in precipitation were found in the north, south, east and the entire Xinjiang. Changes in precipitation in Xinjiang exhibited significant inter-annual scale (quasi-2 and quasi-6 years) and inter-decadal scale (quasi-12 and quasi-23 years). Moreover, the 2–3-year quasi-periodic fluctuation was dominant in regional precipitation and the inter-annual variation had a considerable effect on the regional-scale precipitation variation in Xinjiang. We also found that there were distinctive spatial differences in variation trends and turning points of precipitation in Xinjiang. The results of this study indicated that compared to traditional decomposition methods, the EEMD method, without using any a priori determined basis functions, could effectively extract the reliable multi-scale fluctuations and reveal the intrinsic oscillation properties of climate elements. PMID:27007388

Chironomidae feeding habits in different habitats from a Neotropical floodplain: exploring patterns in aquatic food webs.

PubMed

Butakka, C M M; Ragonha, F H; Train, S; Pinha, G D; Takeda, A M

2016-02-01

Ecological studies on food webs have considerably increased in recent decades, especially in aquatic communities. Because Chironomidae family are highly specious, occurring in almost all aquatic habitats is considered organisms-key to initiate studies on ecological relationships and trophic webs. We tested the hypothesis that the diversity of the morphospecies diet reflects differences on both the food items available among habitats and the preferences of larval feeding. We analyzed the gut content of the seven most abundant Chironomidae morphospecies of the different habitats from the Upper Paraná River. We categorized the food items found into algae, fungal spores, fragments of plants, algae and animal fragments and sponge spicules. We observed the algae predominance in the gut content of morphospecies from lakes. Considering the different regions from each lake, we registered the highest food abundance in the littoral regions in relation to the central regions. From the variety of feeding habits (number of item kinds), we classified Chironomus strenzkei, Tanytarsus sp.1, Procladius sp.1 as generalist morphospecies. We found a nested pattern between food items and Chironomidae morphospecies, where some items were common to all taxa (e.g., Bacillariophyceae algae, especially), while others were found in specific morphospecies (e.g., animals fragments found in Procladius sp.1). The algae represented the most percentage of gut contents of Chironomidae larvae. This was especially true for the individuals from littoral regions, which is probably due to the major densities of algae associated to macrophytes, which are abundant in these regions. Therefore, the feeding behavior of these morphospecies was generalist and not selective, depending only of the available resources.

Basic corrections to predictions of solar cell performance required by nonlinearities

NASA Technical Reports Server (NTRS)

Lindholm, F. A.; Fossum, J. G.; Burgess, E. L.

1976-01-01

The superposition principle is used to derive the approximation that the current-voltage characteristic of an illuminated solar cell is the dark current-voltage characteristic shifted by the short-circuit photocurrent. The derivation requires the linearity of the boundary value problems that underlie the electrical characteristics. The shifting approximation is invalid if considerable photocurrent and considerable dark current both occur within the junction space-charge region; it is invalid also if sizable series resistance is present or if high-injection concentrations of holes and electrons exist within the quasi-neutral regions.

Hydroclimatic influences on seasonal and spatial cholera transmission cycles: Implications for public health intervention in the Bengal Delta

NASA Astrophysics Data System (ADS)

Akanda, Ali Shafqat; Jutla, Antarpreet S.; Alam, Munirul; de Magny, Guillaume Constantin; Siddique, A. Kasem; Sack, R. Bradley; Huq, Anwar; Colwell, Rita R.; Islam, Shafiqul

2011-03-01

Cholera remains a major public health threat in many developing countries around the world. The striking seasonality and annual recurrence of this infectious disease in endemic areas remain of considerable interest to scientists and public health workers. Despite major advances in the ecological and microbiological understanding of Vibrio cholerae, the causative agent of the disease, the role of underlying large-scale hydroclimatic processes in propagating the disease for different seasons and spatial locations is not well understood. Here we show that the cholera outbreaks in the Bengal Delta region are propagated from the coastal to the inland areas and from spring to fall by two distinctly different transmission cycles, premonsoon and postmonsoon, influenced by coastal and terrestrial hydroclimatic processes, respectively. A coupled analysis of the regional hydroclimate and cholera incidence reveals a strong association of the space-time variability of incidence peaks with seasonal processes and extreme climatic events. We explain how the asymmetric seasonal hydroclimatology affects regional cholera dynamics by providing a coastal growth environment for bacteria in spring, while propagating the disease to fall by monsoon flooding. Our findings may serve as the basis for "climate-informed" early warnings and for prompting effective means for intervention and preempting epidemic cholera outbreaks in vulnerable regions.

Phylogeography and population genetic structure of double-crested cormorants (Phalacrocorax auritus)

USGS Publications Warehouse

Mercer, Dacey; Haig, Susan M.; Roby, Daniel D.

2013-01-01

is genetically divergent from other populations in North America (net sequence divergence = 5.85 %;UST for mitochondrial control region = 0.708; FST for microsatellite loci = 0.052). Historical records, contemporary population estimates, and field observations are consistent with recognition of the Alaskan subspecies as distinct and potentially of conservation interest. Our data also indicated the presence of another divergent lineage, associated with the southwestern portion of the species range, as evidenced by highly unique haplotypes sampled in southern California. In contrast, there was little support for recognition of subspecies within the conterminous U.S. and Canada. Rather than genetically distinct regions corresponding to the putative subspecies [P. a. albociliatus (Pacific), P. a. auritus (Interior and North Atlantic), and P. a. floridanus (Southeast)], we observed a distribution of genetic variation consistent with a pattern of isolation by distance. This pattern implies that genetic differences across the range are due to geographic distance, rather than discrete subspecific breaks. Although three of the four traditional subspecies were not genetically distinct, possible demographic separation, habitat differences, and documented declines at some colonies within the regions, suggests that the Pacific and possibly North Atlantic portions of the breeding range may warrant differential consideration from the Interior and Southeast breeding regions.

On the Myths of Indicator Species: Issues and Further Consideration in the Use of Static Concepts for Ecological Applications

PubMed Central

Zettler, Michael L.; Proffitt, C. Edward; Darr, Alexander; Degraer, Steven; Devriese, Lisa; Greathead, Clare; Kotta, Jonne; Magni, Paolo; Martin, Georg; Reiss, Henning; Speybroeck, Jeroen; Tagliapietra, Davide; Van Hoey, Gert; Ysebaert, Tom

2013-01-01

The use of static indicator species, in which species are expected to have a similar sensitivity or tolerance to either natural or human-induced stressors, does not account for possible shifts in tolerance along natural environmental gradients and between biogeographic regions. Their indicative value may therefore be considered at least questionable. In this paper we demonstrate how species responses (i.e. abundance) to changes in sediment grain size and organic matter (OM) alter along a salinity gradient and conclude with a plea for prudency when interpreting static indicator-based quality indices. Six model species (three polychaetes, one amphipod and two bivalves) from the North Sea, Baltic Sea and the Mediterranean Sea region were selected. Our study demonstrated that there were no generic relationships between environment and biota and half of the studied species showed different responses in different seas. Consequently, the following points have to be carefully considered when applying static indicator-based quality indices: (1) species tolerances and preferences may change along environmental gradients and between different biogeographic regions, (2) as environment modifies species autecology, there is a need to adjust indicator species lists along major environmental gradients and (3) there is a risk of including sibling or cryptic species in calculating the index value of a species. PMID:24147123

Ecological half-lives of radiocesium in 16 species in marine biota after the TEPCO's Fukushima Daiichi nuclear power plant accident.

PubMed

Iwata, Kayoko; Tagami, Keiko; Uchida, Shigeo

2013-07-16

TEPCO's Fukushima Daiichi Nuclear Power Plant (FDNPP) accident of March 2011 caused the discharge of a considerable quantity of radionuclides, including (137)Cs. Because of its long half-life (30.17 years), the fate of (137)Cs in the marine biota is of great interest. This study aims to evaluate, using food monitoring data, ecological half-lives (Teco) of (137)Cs in marine biota caught offshore of Fukushima. The data were categorized into two regional groups (north and south) with respect to the FDNPP site, and the regional (137)Cs concentration trend and estimated Teco in the marine biota were appraised. Although the (137)Cs concentration in the seawater in the south was higher than that in the north, Teco values remained relatively consistent among common species of both regions. Teco was then compared to biological half-life (Tb) estimated in laboratory settings. The ratios of Teco/Tb were inconsistent among different groups of marine species. The ratios of Teco/Tb for brown seaweed and bivalves were approximately 1, and the ratios of Teco/Tb for demersal fish ranged from 4.4 to 16.1. The reasons for different ratios of Teco and Tb values may be attributed to environmental and ecological factors, such as different trophic levels.

Acute Myocardial Infarction, Use of Percutaneous Coronary Intervention, and Mortality: A Comparative Effectiveness Analysis Covering Seven European Countries.

PubMed

Hagen, Terje P; Häkkinen, Unto; Belicza, Eva; Fatore, Giovanni; Goude, Fanny

2015-12-01

Percutaneous coronary interventions (PCI) on acute myocardial infarction (AMI) patients have increased substantially in the last 12-15 years because of its clinical effectiveness. The expansion of PCI treatment for AMI patients raises two questions: How did PCI utilization rates vary across European regions, and which healthcare system and regional characteristic variables correlated with the utilization rate? Were the differences in use of PCI associated with differences in outcome, operationalized as 30-day mortality? We obtained our results from a dataset based on the administrative information systems of the populations of seven European countries. PCI rates were highest in the Netherlands, followed by Sweden and Hungary. The probability of receiving PCI was highest in regions with their own PCI facilities and in healthcare systems with activity-based reimbursement systems. Thirty-day mortality rates differed considerably between the countries with the highest rates in Hungary, Scotland, and Finland. Mortality was lowest in Sweden and Norway. The associations between PCI and mortality were remarkable in all age groups and across most countries. Despite extensive risk adjustment, we interpret the associations both as effects of selection and treatments. We observed a lower effect of PCI in the higher age groups in Hungary. Copyright © 2015 John Wiley & Sons, Ltd.

18 CFR 725.3 - Applicability.

Code of Federal Regulations, 2011 CFR

2011-04-01

... result in the long- or short-term adverse impacts associated with: (a) The occupancy or modification of... apply to Level A and B regional or river basin planning activities carried out by regional planning sponsors including consideration of inclusion of site specific projects in Level A or B regional or river...

18 CFR 725.3 - Applicability.

Code of Federal Regulations, 2014 CFR

2014-04-01

... result in the long- or short-term adverse impacts associated with: (a) The occupancy or modification of... apply to Level A and B regional or river basin planning activities carried out by regional planning sponsors including consideration of inclusion of site specific projects in Level A or B regional or river...

18 CFR 725.3 - Applicability.

Code of Federal Regulations, 2013 CFR

2013-04-01

... result in the long- or short-term adverse impacts associated with: (a) The occupancy or modification of... apply to Level A and B regional or river basin planning activities carried out by regional planning sponsors including consideration of inclusion of site specific projects in Level A or B regional or river...

Implementation and Integration of Regional Health Care Data Networks in the Hellenic National Health Service

PubMed Central

Vidalis, Ioannis; Papanikolaou, Christos; Vagelatos, Aristides

2002-01-01

Background Modern health care is provided with close cooperation among many different institutions and professionals, using their specialized expertise in a common effort to deliver best-quality and, at the same time, cost-effective services. Within this context of the growing need for information exchange, the demand for realization of data networks interconnecting various health care institutions at a regional level, as well as a national level, has become a practical necessity. Objectives To present the technical solution that is under consideration for implementing and interconnecting regional health care data networks in the Hellenic National Health System. Methods The most critical requirements for deploying such a regional health care data network were identified as: fast implementation, security, quality of service, availability, performance, and technical support. Results The solution proposed is the use of proper virtual private network technologies for implementing functionally-interconnected regional health care data networks. Conclusions The regional health care data network is considered to be a critical infrastructure for further development and penetration of information and communication technologies in the Hellenic National Health System. Therefore, a technical approach was planned, in order to have a fast cost-effective implementation, conforming to certain specifications. PMID:12554551

Implementation and integration of regional health care data networks in the Hellenic National Health Service.

PubMed

Lampsas, Petros; Vidalis, Ioannis; Papanikolaou, Christos; Vagelatos, Aristides

2002-12-01

Modern health care is provided with close cooperation among many different institutions and professionals, using their specialized expertise in a common effort to deliver best-quality and, at the same time, cost-effective services. Within this context of the growing need for information exchange, the demand for realization of data networks interconnecting various health care institutions at a regional level, as well as a national level, has become a practical necessity. To present the technical solution that is under consideration for implementing and interconnecting regional health care data networks in the Hellenic National Health System. The most critical requirements for deploying such a regional health care data network were identified as: fast implementation, security, quality of service, availability, performance, and technical support. The solution proposed is the use of proper virtual private network technologies for implementing functionally-interconnected regional health care data networks. The regional health care data network is considered to be a critical infrastructure for further development and penetration of information and communication technologies in the Hellenic National Health System. Therefore, a technical approach was planned, in order to have a fast cost-effective implementation, conforming to certain specifications.

Allocation and simulation study of carbon emission quotas among China's provinces in 2020.

PubMed

Zhou, Xing; Guan, Xueling; Zhang, Ming; Zhou, Yao; Zhou, Meihua

2017-03-01

China will form its carbon market in 2017 to focus on the allocation of regional carbon emission quota in order to cope with global warming. The rationality of the regional allocation has become an important consideration for the government in ensuring stable growth in different regions that are experiencing disparity in resource endowment and economic status. Based on constructing the quota allocation indicator system for carbon emission, the emission quota for each province in different scenarios and schemes in 2020 is simulated by the multifactor hybrid weighted Shannon entropy allocation model. The following conclusions are drawn: (1) The top 5 secondary-level indicators that influence provincial quota allocation in weight are as follows: per capita energy consumption, openness, per capita carbon emission, per capita disposable income, and energy intensity. (2) The ratio of carbon emission in 2020 is different from that in 2013 in many scenarios, and the variation is scenario 2 > scenario 1 > scenario 3, with Hubei and Guangdong the provinces with the largest increase and decrease ratios, respectively. (3) In the same scenario, the quota allocation varies in different reduction criteria emphases; if the government emphasizes reduction efficiency, scheme 1 will show obvious adjustment, that is, Hunan, Hubei, Guizhou, and Yunnan will have the largest decrease. The amounts are 4.28, 8.31, 4.04, and 5.97 million tons, respectively.

How to investigate neuro-biochemical relationships on a regional level in humans? Methodological considerations for combining functional with biochemical imaging.

PubMed

Duncan, Niall W; Wiebking, Christine; Muñoz-Torres, Zeidy; Northoff, Georg

2014-01-15

There is an increasing interest in combining different imaging modalities to investigate the relationship between neural and biochemical activity. More specifically, imaging techniques like MRS and PET that allow for biochemical measurement are combined with techniques like fMRI and EEG that measure neural activity in different states. Such combination of neural and biochemical measures raises not only technical issues, such as merging the different data sets, but also several methodological issues. These methodological issues – ranging from hypothesis generation and hypothesis-guided use of technical facilities to target measures and experimental measures – are the focus of this paper. We discuss the various methodological problems and issues raised by the combination of different imaging methodologies in order to investigate neuro-biochemical relationships on a regional level in humans. For example, the choice of transmitter and scan type is discussed, along with approaches to allow the establishment of particular specificities (such as regional or biochemical) to in turn make results fully interpretable. An algorithm that can be used as a form of checklist for designing such multimodal studies is presented. The paper concludes that while several methodological and technical caveats needs to be overcome and addressed, multimodal imaging of the neuro-biochemical relationship provides an important tool to better understand the physiological mechanisms of the human brain.

How to investigate neuro-biochemical relationships on a regional level in humans? Methodological considerations for combining functional with biochemical imaging.

PubMed

Duncan, Niall W; Wiebking, Christine; Munoz-Torres, Zeidy; Northoff, Georg

2013-10-25

There is an increasing interest in combining different imaging modalities to investigate the relationship between neural and biochemical activity. More specifically, imaging techniques like MRS and PET that allow for biochemical measurement are combined with techniques like fMRI and EEG that measure neural activity in different states. Such combination of neural and biochemical measures raises not only technical issues, such as merging the different data sets, but also several methodological issues. These methodological issues - ranging from hypothesis generation and hypothesis-guided use of technical facilities to target measures and experimental measures - are the focus of this paper. We discuss the various methodological problems and issues raised by the combination of different imaging methodologies in order to investigate neuro-biochemical relationships on a regional level in humans. For example, the choice of transmitter and scan type is discussed, along with approaches to allow the establishment of particular specificities (such as regional or biochemical) to in turn make results fully interpretable. An algorithm that can be used as a form of checklist for designing such multimodal studies is presented. The paper concludes that while several methodological and technical caveats needs to be overcome and addressed, multimodal imaging of the neuro-biochemical relationship provides an important tool to better understand the physiological mechanisms of the human brain. Copyright © 2013. Published by Elsevier B.V.

Regional differences in actomyosin contraction shape the primary vesicles in the embryonic chicken brain

NASA Astrophysics Data System (ADS)

Filas, Benjamen A.; Oltean, Alina; Majidi, Shabnam; Bayly, Philip V.; Beebe, David C.; Taber, Larry A.

2012-12-01

In the early embryo, the brain initially forms as a relatively straight, cylindrical epithelial tube composed of neural stem cells. The brain tube then divides into three primary vesicles (forebrain, midbrain, hindbrain), as well as a series of bulges (rhombomeres) in the hindbrain. The boundaries between these subdivisions have been well studied as regions of differential gene expression, but the morphogenetic mechanisms that generate these constrictions are not well understood. Here, we show that regional variations in actomyosin-based contractility play a major role in vesicle formation in the embryonic chicken brain. In particular, boundaries did not form in brains exposed to the nonmuscle myosin II inhibitor blebbistatin, whereas increasing contractile force using calyculin or ATP deepened boundaries considerably. Tissue staining showed that contraction likely occurs at the inner part of the wall, as F-actin and phosphorylated myosin are concentrated at the apical side. However, relatively little actin and myosin was found in rhombomere boundaries. To determine the specific physical mechanisms that drive vesicle formation, we developed a finite-element model for the brain tube. Regional apical contraction was simulated in the model, with contractile anisotropy and strength estimated from contractile protein distributions and measurements of cell shapes. The model shows that a combination of circumferential contraction in the boundary regions and relatively isotropic contraction between boundaries can generate realistic morphologies for the primary vesicles. In contrast, rhombomere formation likely involves longitudinal contraction between boundaries. Further simulations suggest that these different mechanisms are dictated by regional differences in initial morphology and the need to withstand cerebrospinal fluid pressure. This study provides a new understanding of early brain morphogenesis.

Modelling the water energy nexus: should variability in water supply impact on decision making for future energy supply options?

NASA Astrophysics Data System (ADS)

Cullis, James D. S.; Walker, Nicholas J.; Ahjum, Fadiel; Juan Rodriguez, Diego

2018-02-01

Many countries, like South Africa, Australia, India, China and the United States, are highly dependent on coal fired power stations for energy generation. These power stations require significant amounts of water, particularly when fitted with technology to reduce pollution and climate change impacts. As water resources come under stress it is important that spatial variability in water availability is taken into consideration for future energy planning particularly with regards to motivating for a switch from coal fired power stations to renewable technologies. This is particularly true in developing countries where there is a need for increased power production and associated increasing water demands for energy. Typically future energy supply options are modelled using a least cost optimization model such as TIMES that considers water supply as an input cost, but is generally constant for all technologies. Different energy technologies are located in different regions of the country with different levels of water availability and associated infrastructure development and supply costs. In this study we develop marginal cost curves for future water supply options in different regions of a country where different energy technologies are planned for development. These water supply cost curves are then used in an expanded version of the South Africa TIMES model called SATIM-W that explicitly models the water-energy nexus by taking into account the regional nature of water supply availability associated with different energy supply technologies. The results show a significant difference in the optimal future energy mix and in particular an increase in renewables and a demand for dry-cooling technologies that would not have been the case if the regional variability of water availability had not been taken into account. Choices in energy policy, such as the introduction of a carbon tax, will also significantly impact on future water resources, placing additional water demands in some regions and making water available for other users in other regions with a declining future energy demand. This study presents a methodology for modelling the water-energy nexus that could be used to inform the sustainable development planning process in the water and energy sectors for both developed and developing countries.

76 FR 75559 - Notice of Meeting, National Capital Memorial Advisory Commission

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-02

....gov for specific information regarding sites under consideration. (3) Review of H.R. 3278, a bill to... 7, 2011. Stephen E. Whitesell, Regional Director, National Capital Region. [FR Doc. 2011-31042 Filed...

Web-based assessments of physical activity in youth: considerations for design and scale calibration.

PubMed

Saint-Maurice, Pedro F; Welk, Gregory J

2014-12-01

This paper describes the design and methods involved in calibrating a Web-based self-report instrument to estimate physical activity behavior. The limitations of self-report measures are well known, but calibration methods enable the reported information to be equated to estimates obtained from objective data. This paper summarizes design considerations for effective development and calibration of physical activity self-report measures. Each of the design considerations is put into context and followed by a practical application based on our ongoing calibration research with a promising online self-report tool called the Youth Activity Profile (YAP). We first describe the overall concept of calibration and how this influences the selection of appropriate self-report tools for this population. We point out the advantages and disadvantages of different monitoring devices since the choice of the criterion measure and the strategies used to minimize error in the measure can dramatically improve the quality of the data. We summarize strategies to ensure quality control in data collection and discuss analytical considerations involved in group- vs individual-level inference. For cross-validation procedures, we describe the advantages of equivalence testing procedures that directly test and quantify agreement. Lastly, we introduce the unique challenges encountered when transitioning from paper to a Web-based tool. The Web offers considerable potential for broad adoption but an iterative calibration approach focused on continued refinement is needed to ensure that estimates are generalizable across individuals, regions, seasons and countries.

Inter-regional changes in the performance and interpretation of spirometry in Spain: 3E study.

PubMed

López-Campos, José Luis; Soriano, Joan B; Calle, Myriam

2014-11-01

This report shows the results of a nation-wide survey on spirometry to assess regional differences. Observational cross-sectional study conducted by means of a telephone survey in 805 primary care (PC) and specialized centers (SC) in all regions. The survey contacted technicians in charge of spirometry and consisted of 36 questions related to the test. The results showed major differences between regions. Most centers had 1-2 spirometers. The number of spirometry tests per week ranged from 2 to 8.9 in PC and between 34.3 and 98.3 in SC. Some training had been given in most centers (63.6-100% in PC and 60.0-100% in SC) but not on a regular basis. Most centers used several short-acting bronchodilators for the bronchodilation test, but with insufficient inhalations (2.0-3.8 in PC and 2.0-3.3 in SC) and frequently incorrect waiting time (29.4-83.3% PC and 33.3-87.5% in SC). Daily calibration was not performed in all centers (0-100% in PC and 66.7-100% in SC). Significant inter-regional differences in spirometry quality criteria were observed, with 6 or more criteria met in 9.1-84.6% of PC centers and 37.5-100% in SC. Our results show the current situation of spirometry in primary and specialized care in Spain, highlighting considerable variability and areas for improvement. This information should be considered by health officials to improve the quality and accessibility of such tests. Copyright © 2014 SEPAR. Published by Elsevier Espana. All rights reserved.

Natural positive selection and north-south genetic diversity in East Asia.

PubMed

Suo, Chen; Xu, Haiyan; Khor, Chiea-Chuen; Ong, Rick Th; Sim, Xueling; Chen, Jieming; Tay, Wan-Ting; Sim, Kar-Seng; Zeng, Yi-Xin; Zhang, Xuejun; Liu, Jianjun; Tai, E-Shyong; Wong, Tien-Yin; Chia, Kee-Seng; Teo, Yik-Ying

2012-01-01

Recent reports have identified a north-south cline in genetic variation in East and South-East Asia, but these studies have not formally explored the basis of these clinical differences. Understanding the origins of these variations may provide valuable insights in tracking down the functional variants in genomic regions identified by genetic association studies. Here we investigate the genetic basis of these differences with genome-wide data from the HapMap, the Human Genome Diversity Project and the Singapore Genome Variation Project. We implemented four bioinformatic measures to discover genomic regions that are considerably differentiated either between two Han Chinese populations in the north and south of China, or across 22 populations in East and South-East Asia. These measures prioritized genomic stretches with: (i) regional differences in the allelic spectrum for SNPs common to the two Han Chinese populations; (ii) differential evidence of positive selection between the two populations as quantified by integrated haplotype score (iHS) and cross-population extended haplotype homozygosity (XP-EHH); (iii) significant correlation between allele frequencies and geographical latitudes of the 22 populations. We also explored the extent of linkage disequilibrium variations in these regions, which is important in combining genetic association studies from North and South Chinese. Two of the regions that emerged are found in HLA class I and II, suggesting that the HLA imputation panel from the HapMap may not be directly applicable to every Chinese sample. This has important implications to autoimmune studies that plan to impute the classical HLA alleles to fine map the SNP association signals.

Natural positive selection and north–south genetic diversity in East Asia

PubMed Central

Suo, Chen; Xu, Haiyan; Khor, Chiea-Chuen; Ong, Rick TH; Sim, Xueling; Chen, Jieming; Tay, Wan-Ting; Sim, Kar-Seng; Zeng, Yi-Xin; Zhang, Xuejun; Liu, Jianjun; Tai, E-Shyong; Wong, Tien-Yin; Chia, Kee-Seng; Teo, Yik-Ying

2012-01-01

Recent reports have identified a north–south cline in genetic variation in East and South-East Asia, but these studies have not formally explored the basis of these clinical differences. Understanding the origins of these variations may provide valuable insights in tracking down the functional variants in genomic regions identified by genetic association studies. Here we investigate the genetic basis of these differences with genome-wide data from the HapMap, the Human Genome Diversity Project and the Singapore Genome Variation Project. We implemented four bioinformatic measures to discover genomic regions that are considerably differentiated either between two Han Chinese populations in the north and south of China, or across 22 populations in East and South-East Asia. These measures prioritized genomic stretches with: (i) regional differences in the allelic spectrum for SNPs common to the two Han Chinese populations; (ii) differential evidence of positive selection between the two populations as quantified by integrated haplotype score (iHS) and cross-population extended haplotype homozygosity (XP-EHH); (iii) significant correlation between allele frequencies and geographical latitudes of the 22 populations. We also explored the extent of linkage disequilibrium variations in these regions, which is important in combining genetic association studies from North and South Chinese. Two of the regions that emerged are found in HLA class I and II, suggesting that the HLA imputation panel from the HapMap may not be directly applicable to every Chinese sample. This has important implications to autoimmune studies that plan to impute the classical HLA alleles to fine map the SNP association signals. PMID:21792231

Frontal destabilization of Stonebreen, Edgeøya, Svalbard

NASA Astrophysics Data System (ADS)

Strozzi, Tazio; Kääb, Andreas; Schellenberger, Thomas

2017-02-01

In consideration of the strong atmospheric warming that has been observed since the 1990s in polar regions there is a need to quantify mass loss of Arctic ice caps and glaciers and their contribution to sea level rise. In polar regions a large part of glacier ablation is through calving of tidewater glaciers driven by ice velocities and their variations. The Svalbard region is characterized by glaciers with rapid dynamic fluctuations of different types, including irreversible adjustments of calving fronts to a changing mass balance and reversible, surge-type activities. For large areas, however, we do not have much past and current information on glacier dynamic fluctuations. Recently, through frequent monitoring based on repeat optical and synthetic aperture radar (SAR) satellite data, a number of zones of velocity increases have been observed at formerly slow-flowing calving fronts on Svalbard. Here we present the dynamic evolution of the southern lobe of Stonebreen on Edgeøya. We observe a slowly steady retreat of the glacier front from 1971 until 2011, followed by a strong increase in ice surface velocity along with a decrease of volume and frontal extension since 2012. The considerable losses in ice thickness could have made the tide-water calving glacier, which is grounded below sea level some 6 km inland from the 2014 front, more sensitive to surface meltwater reaching its bed and/or warm ocean water increasing frontal ablation with subsequent strong multi-annual ice-flow acceleration.

Level, trends and differentials of infant and child mortality in Yemen.

PubMed

Suchindran, C M; Adlakha, A L

1985-12-01

This study investigates the levels, trends and differentials of infant and child mortality in Yemen. The data used are from the 1979 Yemen Fertility Survey, part of the World Fertility Survey. Mortality rates for 4 age intervals of life are presented: neonatal, postnatal, infant and child. For the birth cohort immediately preceding the survey (1976 1978), the level of infant mortality was estimated as 157/1000 for both sexes and 163 for males and 145 for females. For the birth cohort 1971 1975, the level of child mortality was 95/1000 for both sexes, 78 for males and 112 for females. Analysis of time trends in mortality for the years from 1961 to 1978 indicated substantial declines in neonatal, postneonatal, infant and child mortality. Neonatal mortality declined by almost 33%, and postneonatal mortality by almost 43%. During 1961-1975, child mortality declined by about 39%. A persistent pattern of mortality differentials by sex was found in the data. For all birth cohorts between 1961 and 1978, male neonatal and postneonatal mortality exceeded female neonatal mortality, but male childhood mortality was less than corresponding female mortality. This pattern suggests preferential care and treatment of male offspring. Estimates of infant and child mortality showed considerable regional differences. The eastern region experienced considerably lower risk of infant and childhood mortality than other regions. Breastfeeders aged 1-5 experienced lower mortality rates than nonbreastfeeders. Multivariate analysis with a logistic regression model show the net effect of demographic and socioeconomic factors on mortality.

Social impacts of civil aviation and implications for R and D policy

NASA Technical Reports Server (NTRS)

Mayo, L. H.

1971-01-01

An attempt was made to identify social impacts, both beneficial and detrimental, which would or could flow from the introduction of advanced civil aviation systems. A broad range of social impact areas was investigated which included economic, environmental, political, sociological, psychological, legal, and urban/regional developmental factors. Data are arranged into two major parts. In the first part, a series of Major Policy Issues are identified and discussed which appear, on the basis of the social impact study, to merit serious consideration. The discussion of each "Issue' is presented both to explain its relevance and to raise considerations which will bear on its satisfactory resolution. The second part views the same overall body of information in a different manner: a series of "Findings' are pointed out from which more concrete guidance for R and D policy can be derived, and a set of "Candidate Basic Federal Undertakings' thus derived are presented.

Finely dispersed brown carbon in a smoggy atmosphere

NASA Astrophysics Data System (ADS)

Gorchakov, G. I.; Vasiliev, A. V.; Verichev, K. S.; Semoutnikova, E. G.; Karpov, A. V.

2016-11-01

It is shown that the absorption capacity of smoke aerosol during mass forest and forest-peat fires is determined to a considerable degree by light absorbing organic compounds or brown carbon. According to the data from the AERONET global network of stations [1], the absorption spectra of smoke aerosol vary significantly if airborne particulate matter is contained in brown carbon. It is established that in several cases, the absorption spectra of smoke aerosol are approximated with satisfactory accuracy by exponents. It is shown that the finely dispersed (submicron) fraction of the smoke aerosol makes a major contribution to its optical characteristics in the 0.44-1.02 μm spectral region. Strong variation in the single scattering albedo is discovered in the presence of brown carbon in the smoke aerosol. It is shown that the optical characteristics of coarsely dispersed and finely dispersed fractions of smoke aerosol differ considerably.

DS-CDMA satellite diversity reception for personal satellite communication: Downlink performance analysis

NASA Technical Reports Server (NTRS)

DeGaudenzi, Riccardo; Giannetti, Filippo

1995-01-01

The downlink of a satellite-mobile personal communication system employing power-controlled Direct Sequence Code Division Multiple Access (DS-CDMA) and exploiting satellite-diversity is analyzed and its performance compared with a more traditional communication system utilizing single satellite reception. The analytical model developed has been thoroughly validated by means of extensive Monte Carlo computer simulations. It is shown how the capacity gain provided by diversity reception shrinks considerably in the presence of increasing traffic or in the case of light shadowing conditions. Moreover, the quantitative results tend to indicate that to combat system capacity reduction due to intra-system interference, no more than two satellites shall be active over the same region. To achieve higher system capacity, differently from terrestrial cellular systems, Multi-User Detection (MUD) techniques are likely to be required in the mobile user terminal, thus considerably increasing its complexity.

Landscape metrics for assessment of landscape destruction and rehabilitation.

PubMed

Herzog, F; Lausch, A; Müller, E; Thulke, H H; Steinhardt, U; Lehmann, S

2001-01-01

This investigation tested the usefulness of geometry-based landscape metrics for monitoring landscapes in a heavily disturbed environment. Research was carried out in a 75 sq km study area in Saxony, eastern Germany, where the landscape has been affected by surface mining and agricultural intensification. Landscape metrics were calculated from digital maps (1912, 1944, 1973, 1989) for the entire study area and for subregions (river valleys, plains), which were defined using the original geology and topography of the region. Correlation and factor analyses were used to select a set of landscape metrics suitable for landscape monitoring. Little land-use change occurred in the first half of the century, but political decisions and technological developments led to considerable change later. Metrics showed a similar pattern with almost no change between 1912 and 1944, but dramatic changes after 1944. Nonparametric statistical methods were used to test whether metrics differed between river valleys and plains. Significant differences in the metrics for these regions were found in the early maps (1912, 1944), but these differences were not significant in 1973 or 1989. These findings indicate that anthropogenic influences created a more home geneous landscape.

Nuclear and mitochondrial rDNA variability in Crinipellis perniciosa from different geographic origins and hosts.

PubMed

de Arruda, Maricília C C; Ferreira, Marisa A S V; Miller, Robert N G; Resende, Mário Lúcio V; Felipe, Maria Sueli S

2003-01-01

Genetic variability in Crinipellis perniciosa, the causal organism of witches' broom disease in Theobroma cacao, was determined in strains originating from T. cacao and other susceptible host species Heteropterys acutifolia and Solanum lycocarpum in Brazil, in order to clarify host specificity and geographical variability. RFLP analysis of the ribosomal DNA ITS regions (rDNA ITS), and the mitochondrial DNA small subunit ribosomal DNA gene (mtDNA SSU rDNA) did not reveal any genetic variability in 120 tested strains, possibly serving only as species level markers. Genetic variability was observed in the ribosomal DNA IGS spacer region, in terms of IGS size, RFLPs and sequence data. Phylogenetic analyses (using CLUSTAL W, PHYLIP and TREEVIEW) indicated considerable differences between C. perniciosa strains from T. cacao and those from H. acutifolia (85-86%) and S. lycocarpum (95-96%). Sequence differences also indicated that C. perniciosa from T. cacao in Bahia is less variable (98%) when compared to the pathogen on T. cacao in Amazonas (97-98%), perhaps reflecting a recent introduction to T. cacao in Bahia.

A Comparative thermophysiological study in sport bras for running

NASA Astrophysics Data System (ADS)

Carneiro, L. P.; Miranda, T. M. R.; Catarino, A.

2017-10-01

Comfort in clothing is essential for user’s performance and is considered as a quality factor when choosing a particular piece of garment. Sportswear’s need include comfort and functionality, meaning that the thermo-physiological properties are of extreme importance. The aim of this work consists in comparing six different models of sports bra used specifically for running, taking into consideration the aspects of the thermo-physiological properties, air permeability, moisture behaviour, and friction. This paper is part of an ongoing research aiming to establish a comprehension about function and comfort characteristics for sport bras and propose a new bra with improved characteristics both in ergonomics design as well as in comfort performance. The thermal characterization of different regions on each bra were tested using Alambeta apparatus, Textest FX 3300 for air permeability and Frictorq for friction. Evaporation tests were also carried out in different regions on each bra at 37ºC corresponding to internal temperature of the human body. The results show that raw material, structures and construction can have influence in the properties studied.

Velocity and Density Heterogeneities of the Tien-Shan Lithosphere

NASA Astrophysics Data System (ADS)

Sabitova, T. M.; Lesik, O. M.; Adamova, A. A.

The Tien-Shan orogene is a region in which the earth's crust undergoes considerable thickening and tangential compression. Under these conditions the lithosphere heterogeneities (composi tion, rheological) create the prerequisites for the development of various phenomena of tectonic layering (lateral shearing, different deformation of layers). To study the distribution of velocity, density and other elastic parameters, the results from a seismic tomography study on P-wave as well as S-wave velocities were used. Using empirical as well as theoretical formulas on the relationship between velocity, density and silica content in rocks, their distribution in the Tien-Shan's lithosphere has been calculated. In addition, other elastic parameters, such as Young's modulus, shear modulus, Poisson's ratio and coefficient of general compressions have been determined. Zoning of different types of crust was carried out for the region investigated. The characteristics of the "crust-mantle" transition have been investi gated. Large blocks with different types of the earth's crust were distinguished. Layers with inverse values of velocity, density and shear and Young modulus are revealed in the Tien-Shan lithosphere. All of the above described features open new ways to solve geodynamics problems.

Comparing flood loss models of different complexity

NASA Astrophysics Data System (ADS)

Schröter, Kai; Kreibich, Heidi; Vogel, Kristin; Riggelsen, Carsten; Scherbaum, Frank; Merz, Bruno

2013-04-01

Any deliberation on flood risk requires the consideration of potential flood losses. In particular, reliable flood loss models are needed to evaluate cost-effectiveness of mitigation measures, to assess vulnerability, for comparative risk analysis and financial appraisal during and after floods. In recent years, considerable improvements have been made both concerning the data basis and the methodological approaches used for the development of flood loss models. Despite of that, flood loss models remain an important source of uncertainty. Likewise the temporal and spatial transferability of flood loss models is still limited. This contribution investigates the predictive capability of different flood loss models in a split sample cross regional validation approach. For this purpose, flood loss models of different complexity, i.e. based on different numbers of explaining variables, are learned from a set of damage records that was obtained from a survey after the Elbe flood in 2002. The validation of model predictions is carried out for different flood events in the Elbe and Danube river basins in 2002, 2005 and 2006 for which damage records are available from surveys after the flood events. The models investigated are a stage-damage model, the rule based model FLEMOps+r as well as novel model approaches which are derived using data mining techniques of regression trees and Bayesian networks. The Bayesian network approach to flood loss modelling provides attractive additional information concerning the probability distribution of both model predictions and explaining variables.

Lessons learned from the initial sequencing of the pig genome: comparative analysis of an 8 Mb region of pig chromosome 17

PubMed Central

Hart, Elizabeth A; Caccamo, Mario; Harrow, Jennifer L; Humphray, Sean J; Gilbert, James GR; Trevanion, Steve; Hubbard, Tim; Rogers, Jane; Rothschild, Max F

2007-01-01

Background We describe here the sequencing, annotation and comparative analysis of an 8 Mb region of pig chromosome 17, which provides a useful test region to assess coverage and quality for the pig genome sequencing project. We report our findings comparing the annotation of draft sequence assembled at different depths of coverage. Results Within this region we annotated 71 loci, of which 53 are orthologous to human known coding genes. When compared to the syntenic regions in human (20q13.13-q13.33) and mouse (chromosome 2, 167.5 Mb-178.3 Mb), this region was found to be highly conserved with respect to gene order. The most notable difference between the three species is the presence of a large expansion of zinc finger coding genes and pseudogenes on mouse chromosome 2 between Edn3 and Phactr3 that is absent from pig and human. All of our annotation has been made publicly available in the Vertebrate Genome Annotation browser, VEGA. We assessed the impact of coverage on sequence assembly across this region and found, as expected, that increased sequence depth resulted in fewer, longer contigs. One-third of our annotated loci could not be fully re-aligned back to the low coverage version of the sequence, principally because the transcripts are fragmented over several contigs. Conclusion We have demonstrated the considerable advantages of sequencing at increased read depths and discuss the implications that lower coverage sequence may have on subsequent comparative and functional studies, particularly those involving complex loci such as GNAS. PMID:17705864

Phylogeography of the dark fruit-eating bat Artibeus obscurus in the Brazilian Amazon.

PubMed

Ferreira, Wallax Augusto Silva; Borges, Bárbara do Nascimento; Rodrigues-Antunes, Symara; de Andrade, Fernanda Atanaena Gonçalves; Aguiar, Gilberto Ferreira de Souza; de Sousa e Silva-Junior, José; Marques-Aguiar, Suely Aparecida; Harada, Maria Lúcia

2014-01-01

Artibeus obscurus (Mammalia: Chiroptera) is endemic to South America, being found in at least 18 Brazilian states. Recent studies revealed that different populations of this genus present distinct phylogeographic patterns; however, very little is known on the population genetics structure of A. obscurus in the Amazon rainforest. Here, using a fragment (1010bp) of the mitochondrial gene cytochrome b from 87 samples, we investigated patterns of genetic divergence among populations of A. obscurus from different locations in the Brazilian Amazon rainforest and compared them with other Brazilian and South American regions. Analysis of molecular variance (AMOVA), fixation index (Fst) analysis, and phylogeographic patterns showed divergence between two major monophyletic groups, each one corresponding to a geographic region associated with the Atlantic and Amazon forest biomes. The Atlantic forest clusters formed a monophyletic group with a high bootstrap support and a fragmented distribution that follows the pattern predicted by the Refuge Theory. On the other hand, a different scenario was observed for the Amazon forest, where no fragmentation was identified. The AMOVA results revealed a significant geographic heterogeneity in the distribution of genetic variation, with 70% found within populations across the studied populations (Fst values ranging from 0.05864 to 0.09673; φST = 0.55). The intrapopulational analysis revealed that one population (Bragança) showed significant evidence of population expansion, with the formation of 2 distinct phylogroups, suggesting the occurrence of a subspecies or at least a different population in this region. These results also suggest considerable heterogeneity for A. obscurus in the Amazon region.

Analysis of Thermal Structure of Arctic Lakes at Local and Regional Scales Using in Situ and Multidate Landsat-8 Data

NASA Astrophysics Data System (ADS)

Huang, Yan; Liu, Hongxing; Hinkel, Kenneth; Yu, Bailang; Beck, Richard; Wu, Jianping

2017-11-01

The Arctic coastal plain is covered with numerous thermokarst lakes. These lakes are closely linked to climate and environmental change through their heat and water budgets. We examined the intralake thermal structure at the local scale and investigated the water temperature pattern of lakes at the regional scale by utilizing extensive in situ measurements and multidate Landsat-8 remote sensing data. Our analysis indicates that the lake skin temperatures derived from satellite thermal sensors during most of the ice-free summer period effectively represent the lake bulk temperature because the lakes are typically well-mixed and without significant vertical stratification. With the relatively high-resolution Landsat-8 thermal data, we were able to quantitatively examine intralake lateral temperature differences and gradients in relation to geographical location, topography, meteorological factors, and lake morphometry for the first time. Our results suggest that wind speed and direction not only control the vertical stratification but also influences lateral differences and gradients of lake surface temperature. Wind can considerably reduce the intralake temperature gradient. Interestingly, we found that geographical location (latitude, longitude, distance to the ocean) and lake morphometry (surface size, depth, volume) not only control lake temperature regionally but also affect the lateral temperature gradient and homogeneity level within each individual lake. For the Arctic coastal plain, at regional scales, inland and southern lakes tend to have larger horizontal temperature differences and gradients compared to coastal and northern lakes. At local scales, large and shallow lakes tend to have large lateral temperature differences relative to small and deep lakes.

Operational considerations for implementing regional sediment management plans in the northern Gulf of Mexico

USGS Publications Warehouse

Underwood, Steven G.; Khalil, Syed M.; Byrnes, Mark R.; Steyer, Gregory D.; Raynie, Richard C

2015-01-01

Development of a comprehensive and stakeholder-driven Regional Sediment Management plan can provide the basis for long-term sustainable resource use and protection. This paper highlights three operational components that can positively influence sediment management at a regional scale, including (1) integration of an operational sediment budget, (2) development of a monitoring and adaptive management plan, and (3) development of a regional sediment availability and allocation program. These components seek to incorporate science and adaptive management through implementation of an organized and well-documented decision making process. They represent a coordinated framework that could serve as a guide for unifying financial investments in regional sediment management plans. Collectively, they establish an integrated process for addressing uncertainties about future system change in light of shrinking federal and state budgets, competing demands for sediment resources within riverine and marine waters, and policy considerations related to sediment/water use (e.g., navigation and commerce versus environmental management).

Atmospheric inversion of the surface CO2 flux with 13CO2 constraint

NASA Astrophysics Data System (ADS)

Chen, J. M.; Mo, G.; Deng, F.

2013-10-01

Observations of 13CO2 at 73 sites compiled in the GLOBALVIEW database are used for an additional constraint in a global atmospheric inversion of the surface CO2 flux using CO2 observations at 210 sites for the 2002-2004 period for 39 land regions and 11 ocean regions. This constraint is implemented using the 13CO2/CO2 flux ratio modeled with a terrestrial ecosystem model and an ocean model. These models simulate 13CO2 discrimination rates of terrestrial photosynthesis and respiration and ocean-atmosphere diffusion processes. In both models, the 13CO2 disequilibrium between fluxes to and from the atmosphere is considered due to the historical change in atmospheric 13CO2 concentration. For the 2002-2004 period, the 13CO2 constraint on the inversion increases the total land carbon sink from 3.40 to 3.70 Pg C yr-1 and decreases the total oceanic carbon sink from 1.48 to 1.12 Pg C yr-1. The largest changes occur in tropical areas: a considerable decrease in the carbon source in the Amazon forest, and this decrease is mostly compensated by increases in the ocean region immediately west of the Amazon and the southeast Asian land region. Our further investigation through different treatments of the 13CO2/CO2 flux ratio used in the inversion suggests that variable spatial distributions of the 13CO2 isotopic discrimination rate simulated by the models over land and ocean have considerable impacts on the spatial distribution of the inverted CO2 flux over land and the inversion results are not sensitive to errors in the estimated disequilibria over land and ocean.

Multiple sclerosis: a geographical hypothesis.

PubMed

Carlyle, I P

1997-12-01

Multiple sclerosis remains a rare neurological disease of unknown aetiology, with a unique distribution, both geographically and historically. Rare in equatorial regions, it becomes increasingly common in higher latitudes; historically, it was first clinically recognized in the early nineteenth century. A hypothesis, based on geographical reasoning, is here proposed: that the disease is the result of a specific vitamin deficiency. Different individuals suffer the deficiency in separate and often unique ways. Evidence to support the hypothesis exists in cultural considerations, in the global distribution of the disease, and in its historical prevalence.

Practical photochemistry: General considerations

NASA Astrophysics Data System (ADS)

Hutchison, J.

1986-05-01

Practical aspects of laboratory scale preparative photochemistry are discussed under the headings of: (1) lamps: dimensions, power ratings, spectral distributions and output intensities of different lamp types; (2) the reaction mixture: factors involved in establishing the most suitable wavelength region to use to carry out a particular reaction; the selection of the appropriate solvents, filters, and glassware; concentration of the photoactive component; (3) preparative photoreactions: immersion well, falling film, external irradiation and elliptical configurations; (4) apparatus for quantitative work: carousel and optical bench arrangements; (5) hazards: effects of ultraviolet radiation on eyes and skin and precautions to be taken.

Downward continuation of gravity information from satellite to satellite tracking or satellite gradiometry in local areas

NASA Technical Reports Server (NTRS)

Rummel, R.

1975-01-01

Integral formulas in the parameter domain are used instead of a representation by spherical harmonics. The neglected regions will cause a truncation error. The application of the discrete form of the integral equations connecting the satellite observations with surface gravity anomalies is discussed in comparison with the least squares prediction method. One critical point of downward continuation is the proper choice of the boundary surface. Practical feasibilities are in conflict with theoretical considerations. The properties of different approaches for this question are analyzed.

Ozone production potential following convective redistribution of biomass burning emissions

NASA Technical Reports Server (NTRS)

Pickering, Kenneth E.; Thompson, Anne M.; Scala, John R.; Tao, Wei-Kuo; Simpson, Joanne

1992-01-01

The effects of deep convection on the potential for forming ozone in the free troposphere have been simulated for regions where the trace gas composition is influenced by biomass burning. Cloud photochemical and dynamic simulations based on observations in the 1980 and 1985 Brazilian campaigns form the basis of a sensitivity study of the ozone production potential under differing conditions. It is seen that there is considerably more ozone formed in the middle and upper troposphere when convection has redistributed hydrocarbons, NO(x), and CO compared to the example of no convection.

Axelrod's model with surface tension

NASA Astrophysics Data System (ADS)

Pace, Bruno; Prado, Carmen P. C.

2014-06-01

In this work we propose a subtle change in Axelrod's model for the dissemination of culture. The mechanism consists of excluding from the set of potentially interacting neighbors those that would never possibly exchange. Although the alteration proposed does not alter the state space topologically, it yields significant qualitative changes, specifically the emergence of surface tension, driving the system in some cases to metastable states. The transient behavior is considerably richer, and cultural regions become stable leading to the formation of different spatiotemporal patterns. A metastable "glassy" phase emerges between the globalized phase and the disordered, multicultural phase.

Tinea capitis and tinea corporis with a severe inflammatory response due to Trichophyton tonsurans.

PubMed

Hryncewicz-Gwóźdź, Anita; Beck-Jendroschek, Vera; Brasch, Jochen; Kalinowska, Katarzyna; Jagielski, Tomasz

2011-10-01

Trichophyton tonsurans is an anthropophilic dermatophyte, with a worldwide distribution, although its prevalence varies considerably between different geographical regions. Whereas in North America infections due to this fungus are exceptionally common, on the European continent they appear relatively seldom. Although T. tonsurans is primarily associated with tinea capitis, it can also be the cause of tinea corporis and tinea unguium. The course of infection is usually only mildly symptomatic. We describe here two cases of urease-positive T. tonsurans infections with atypically extensive cutaneous lesions and severe inflammatory responses. .

Prometheus unbound: A study of the Dallas/Fort Worth Regional Airport. [Socio-economic considerations

NASA Technical Reports Server (NTRS)

Starling, J. D.; Brown, J.; Dominus, M. I.

1975-01-01

The history of the controversies in the development of the Dallas/Fort Worth Regional Airport is detailed. Present technological and organizational management problems are outlined. Maps and illustrations are included.

Chemical composition of vegetation along urbanisation gradients in two European cities.

PubMed

Sæbø, A; Hanslin, H M; Torp, T; Lierhagen, S; Gawronska, H; Dzierzanowski, K; Gawronski, S

2015-03-01

Accumulation of particulate matter (PM) and metals on leaves of three deciduous woody species was studied along urbanisation gradients in Stavanger and Warsaw. Differences between rural and urban sites explained most of the observed variation in leaf chemistry, followed by differences between regions. Highest leaf accumulation of elements was found in Warsaw, but also composition of elements differed between the cities. Overall, species showed similar patterns of element accumulation, but differed in accumulation of specific elements. These differences could in part be explained by differences in epicuticular waxes and PM accumulation. Expected source of elements and their chemical characteristics did not explain the observed accumulation patterns. A better differentiation between elements taken up from soil and air would be required for his. Species specific accumulation of elements has to be taken into consideration using leaf samples for biomonitoring. Copyright © 2015 Elsevier Ltd. All rights reserved.

Comparison of extracellular protein profiles of seven serotypes of mutans streptococci grown under controlled conditions.

PubMed

Hardy, L N; Knox, K W; Brown, R A; Wicken, A J; Fitzgerald, R J

1986-05-01

Extracellular proteins produced by the four human commensal species of mutans streptococci were analysed. The organisms used were Streptococcus mutans, serotypes c, e and f, Streptococcus cricetus, serotype a, Streptococcus rattus, serotype b, and Streptococcus sobrinus, serotypes d and g. They were grown in continuous culture at different generation times and pH values in media containing either glucose or fructose to determine the extent of variation in extracellular protein production that could occur for an individual strain. The results for different organisms grown under the same conditions were then compared. The total amount of protein of molecular mass greater than or equal to 60 kDa varied considerably with the growth conditions and with the strain. Generally more protein was present at a higher pH, conditions under which the organisms also form more lipoteichoic acid. With respect to individual protein components SDS-PAGE proved better than isoelectric focusing for detecting phenotypic responses by a particular strain to environmental changes and differences between the different strains. Differences in the molecular masses of protein components were particularly pronounced in the regions designated P1 (185-200 kDa), P2 (130-155 kDa) and P3 (60-95 kDa). Every strain produced at least one component in the P1 region that cross-reacted with antiserum to the purified protein from S. mutans serotype c, a protein which is indistinguishable from antigens B and I/II. Two components in the P2 region were dominant in the case of S. cricetus and S. sobrinus strains and showed glucosyltransferase (GTF) activity. GTF activity was also detected in the P3 region, particularly with S. mutans strains.

Estimation of effective brain connectivity with dual Kalman filter and EEG source localization methods.

PubMed

Rajabioun, Mehdi; Nasrabadi, Ali Motie; Shamsollahi, Mohammad Bagher

2017-09-01

Effective connectivity is one of the most important considerations in brain functional mapping via EEG. It demonstrates the effects of a particular active brain region on others. In this paper, a new method is proposed which is based on dual Kalman filter. In this method, firstly by using a brain active localization method (standardized low resolution brain electromagnetic tomography) and applying it to EEG signal, active regions are extracted, and appropriate time model (multivariate autoregressive model) is fitted to extracted brain active sources for evaluating the activity and time dependence between sources. Then, dual Kalman filter is used to estimate model parameters or effective connectivity between active regions. The advantage of this method is the estimation of different brain parts activity simultaneously with the calculation of effective connectivity between active regions. By combining dual Kalman filter with brain source localization methods, in addition to the connectivity estimation between parts, source activity is updated during the time. The proposed method performance has been evaluated firstly by applying it to simulated EEG signals with interacting connectivity simulation between active parts. Noisy simulated signals with different signal to noise ratios are used for evaluating method sensitivity to noise and comparing proposed method performance with other methods. Then the method is applied to real signals and the estimation error during a sweeping window is calculated. By comparing proposed method results in different simulation (simulated and real signals), proposed method gives acceptable results with least mean square error in noisy or real conditions.

A New Visual Trap for Rhagoletis cerasi (L.) (Diptera: Tephritidae).

PubMed

Daniel, Claudia; Mathis, Samuel; Feichtinger, Georg

2014-07-18

The European cherry fruit fly, Rhagoletis cerasi (L.) (Diptera: Tephritidae), is the most important pest of sweet cherries in Europe. The aim of our experiments was to develop a new, cost-efficient, lead chromate-free and more eco-friendly trap for monitoring and mass trapping of R. cerasi. Five different-colored yellow panels and three different trap shapes were compared to a standard Rebell(®) amarillo trap in three experimental orchards in 2012. Trap color F, with a strong increase in reflectance at 500-550 nm and a secondary peak in the UV-region at 300-400 nm, captured significantly more flies than the standard Rebell(®) amarillo trap. Yellow traps with increased reflectance in the blue region (400-500 nm) were least attractive. Trap shape was of minor importance, as long as the object was three-dimensional and visible from all directions. Based on economic and practical considerations, a cylinder-shaped trap "UFA-Samen Kirschenfliegenfalle" was developed for commercial use and is currently under on-farm evaluation.

Parasitism of Trombidium brevimanum larvae on agrobiont linyphiid spiders from Germany.

PubMed

Tomić, Vladimir; Mąkol, Joanna; Stamenković, Srdjan; Büchs, Wolfgang; Prescher, Sabine; Sivčev, Ivan; Graora, Draga; Sivčev, Lazar; Gotlin-Čuljak, Tatjana; Dudić, Boris

2015-08-01

An experiment on three differently-managed agricultural fields in Ahlum, Germany, which aimed at establishing the impact of different management systems on the biodiversity of predators and decomposers, yielded a significant number of spiders parasitized by larvae of Trombidium brevimanum (Actinotrichida, Parasitengona, Trombidiidae). Spider data from the whole sampling period (September 2010-July 2012), indicated that ectoparasitic larvae were recorded only on spiders in pitfall traps in the period of June-July 2011. In this period, only eight species of Linyphiidae--out of 42 species assigned to nine spider families recorded from the study area--were parasitized by mites; considerable levels of parasitism were recorded on Erigone atra, E. dentipalpis, and Oedothorax apicatus. The highest prevalence of parasitism was recorded on the organic field for E. atra (29%), while on the integrated and conventional fields significantly fewer parasitized spiders were observed. The preferred attachment sites on the spider host were regions with softer cuticle, especially regions on the carapace and on the abdomen, adjacent to the pedicel.

Performance of the Hydrological Portion of a Simple Water Quality Model in Different Climatic Regions

NASA Astrophysics Data System (ADS)

Moore, K.; Pierson, D.; Pettersson, K.; Naden, P.; Allott, N.; Jennings, E.; Tamm, T.; Järvet, A.; Nickus, U.; Thies, H.; Arvola, L.; Järvinen, M.; Schneiderman, E.; Zion, M.; Lounsbury, D.

2004-05-01

We are applying an existing watershed model in the EU CLIME (Climate and Lake Impacts in Europe) project to evaluate the effects of weather on seasonal and annual delivery of N, P, and DOC to lakes. Model calibration is based on long-term records of weather and water quality data collected from sites in different climatic regions spread across Europe and in New York State. The overall aim of the CLIME project is to develop methods and models to support lake and catchment management under current climate conditions and make predictions under future climate scenarios. Scientists from 10 partner countries are collaborating on developing a consistent approach to defining model parameters for the Generalized Watershed Loading Functions (GWLF) model, one of a larger suite of models used in the project. An example of the approach for the hydrological portion of the GWLF model will be presented, with consideration of the balance between model simplicity, ease of use, data requirements, and realistic predictions.

Spatial variation in the climatic predictors of species compositional turnover and endemism

PubMed Central

Di Virgilio, Giovanni; Laffan, Shawn W; Ebach, Malte C; Chapple, David G

2014-01-01

Previous research focusing on broad-scale or geographically invariant species-environment dependencies suggest that temperature-related variables explain more of the variation in reptile distributions than precipitation. However, species–environment relationships may exhibit considerable spatial variation contingent upon the geographic nuances that vary between locations. Broad-scale, geographically invariant analyses may mask this local variation and their findings may not generalize to different locations at local scales. We assess how reptile–climatic relationships change with varying spatial scale, location, and direction. Since the spatial distributions of diversity and endemism hotspots differ for other species groups, we also assess whether reptile species turnover and endemism hotspots are influenced differently by climatic predictors. Using New Zealand reptiles as an example, the variation in species turnover, endemism and turnover in climatic variables was measured using directional moving window analyses, rotated through 360°. Correlations between the species turnover, endemism and climatic turnover results generated by each rotation of the moving window were analysed using multivariate generalized linear models applied at national, regional, and local scales. At national-scale, temperature turnover consistently exhibited the greatest influence on species turnover and endemism, but model predictive capacity was low (typically r2 = 0.05, P < 0.001). At regional scales the relative influence of temperature and precipitation turnover varied between regions, although model predictive capacity was also generally low. Climatic turnover was considerably more predictive of species turnover and endemism at local scales (e.g., r2 = 0.65, P < 0.001). While temperature turnover had the greatest effect in one locale (the northern North Island), there was substantial variation in the relative influence of temperature and precipitation predictors in the remaining four locales. Species turnover and endemism hotspots often occurred in different locations. Climatic predictors had a smaller influence on endemism. Our results caution against assuming that variability in temperature will always be most predictive of reptile biodiversity across different spatial scales, locations and directions. The influence of climatic turnover on the species turnover and endemism of other taxa may exhibit similar patterns of spatial variation. Such intricate variation might be discerned more readily if studies at broad scales are complemented by geographically variant, local-scale analyses. PMID:25473479

Allele-specific HLA-DR typing by mass spectrometry: an alternative to hybridization-based typing methods.

PubMed

Worrall, T A; Schmeckpeper, B J; Corvera, J S; Cotter, R J

2000-11-01

The primer oligomer base extension (PROBE) reaction, combined with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, is used to characterize HLA-DR2 polymorphism. Alleles are distinguished rapidly and accurately by measuring the mass of primer extension products at every known variable region of HLA-DR2 alleles. Since differentiation of alleles by PROBE relies on measuring differences in extension product mass rather than differences in hybridization properties, mistyped alleles resulting from nonspecific hybridization are absent. The method shows considerable potential for high-throughput screening of HLA-DR polymorphism in a chip-based format, including rapid tissue typing of unrelated volunteer donors.

Contribution potential of glaciers to water availability in different climate regimes

PubMed Central

Kaser, Georg; Großhauser, Martin; Marzeion, Ben

2010-01-01

Although reliable figures are often missing, considerable detrimental changes due to shrinking glaciers are universally expected for water availability in river systems under the influence of ongoing global climate change. We estimate the contribution potential of seasonally delayed glacier melt water to total water availability in large river systems. We find that the seasonally delayed glacier contribution is largest where rivers enter seasonally arid regions and negligible in the lowlands of river basins governed by monsoon climates. By comparing monthly glacier melt contributions with population densities in different altitude bands within each river basin, we demonstrate that strong human dependence on glacier melt is not collocated with highest population densities in most basins. PMID:21059938

Atypical white-matter microstructure in congenitally deaf adults: A region of interest and tractography study using diffusion-tensor imaging.

PubMed

Karns, Christina M; Stevens, Courtney; Dow, Mark W; Schorr, Emily M; Neville, Helen J

2017-01-01

Considerable research documents the cross-modal reorganization of auditory cortices as a consequence of congenital deafness, with remapped functions that include visual and somatosensory processing of both linguistic and nonlinguistic information. Structural changes accompany this cross-modal neuroplasticity, but precisely which specific structural changes accompany congenital and early deafness and whether there are group differences in hemispheric asymmetries remain to be established. Here, we used diffusion tensor imaging (DTI) to examine microstructural white matter changes accompanying cross-modal reorganization in 23 deaf adults who were genetically, profoundly, and congenitally deaf, having learned sign language from infancy with 26 hearing controls who participated in our previous fMRI studies of cross-modal neuroplasticity. In contrast to prior literature using a whole-brain approach, we introduce a semiautomatic method for demarcating auditory regions in which regions of interest (ROIs) are defined on the normalized white matter skeleton for all participants, projected into each participants native space, and manually constrained to anatomical boundaries. White-matter ROIs were left and right Heschl's gyrus (HG), left and right anterior superior temporal gyrus (aSTG), left and right posterior superior temporal gyrus (pSTG), as well as one tractography-defined region in the splenium of the corpus callosum connecting homologous left and right superior temporal regions (pCC). Within these regions, we measured fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD), and white-matter volume. Congenitally deaf adults had reduced FA and volume in white matter structures underlying bilateral HG, aSTG, pSTG, and reduced FA in pCC. In HG and pCC, this reduction in FA corresponded with increased RD, but differences in aSTG and pSTG could not be localized to alterations in RD or AD. Direct statistical tests of hemispheric asymmetries in these differences indicated the most prominent effects in pSTG, where the largest differences between groups occurred in the right hemisphere. Other regions did not show significant hemispheric asymmetries in group differences. Taken together, these results indicate that atypical white matter microstructure and reduced volume underlies regions of superior temporal primary and association auditory cortex and introduce a robust method for quantifying volumetric and white matter microstructural differences that can be applied to future studies of special populations. Published by Elsevier B.V.

Common Trajectories of Regional Competitiveness in the Knowledge Economy: A European Investigation

ERIC Educational Resources Information Center

Brioschi, Maria Sole; Cassia, Lucio

2006-01-01

This paper analyses a number of European regions which, in the last two decades, have exhibited a significant shift towards knowledge-intensive industrial sectors coupled with a considerable increase in competitiveness and growth. The analysis identifies the main factors of territorial development behind each regional renewal process and captures…

Structural characterization of Helicobacter pylori dethiobiotin synthetase reveals differences between family members

DOE Office of Scientific and Technical Information (OSTI.GOV)

Porebski, Przemyslaw J.; Klimecka, Maria; Chruszcz, Maksymilian

2012-07-11

Dethiobiotin synthetase (DTBS) is involved in the biosynthesis of biotin in bacteria, fungi, and plants. As humans lack this pathway, DTBS is a promising antimicrobial drug target. We determined structures of DTBS from Helicobacter pylori (hpDTBS) bound with cofactors and a substrate analog, and described its unique characteristics relative to other DTBS proteins. Comparison with bacterial DTBS orthologs revealed considerable structural differences in nucleotide recognition. The C-terminal region of DTBS proteins, which contains two nucleotide-recognition motifs, differs greatly among DTBS proteins from different species. The structure of hpDTBS revealed that this protein is unique and does not contain a C-terminalmore » region containing one of the motifs. The single nucleotide-binding motif in hpDTBS is similar to its counterpart in GTPases; however, isothermal titration calorimetry binding studies showed that hpDTBS has a strong preference for ATP. The structural determinants of ATP specificity were assessed with X-ray crystallographic studies of hpDTBS-ATP and hpDTBS-GTP complexes. The unique mode of nucleotide recognition in hpDTBS makes this protein a good target for H. pylori-specific inhibitors of the biotin synthesis pathway.« less

Mesopause region wind, temperature and airglow irradiance above Eureka, Nunavut

NASA Astrophysics Data System (ADS)

Kristoffersen, Samuel; Ward, William E.; Vail, Christopher; Shepherd, Marianna

2016-07-01

The PEARL All Sky Imager (PASI, airglow images), the Spectral Airglow Temperature Imager (SATI, airglow irradiance and temperature) and the E-Region Wind Interferometer II (ERWIN2, wind, airglow irradiance and temperature) are co-located at the Polar Environment Atmospheric Research Laboratory (PEARL)in Eureka, Nunavut (80 N, 86 W). These instruments view the wind, temperature and airglow irradiance of hydroxyl (all three) O2 (ERWIN2 and SATI), sodium (PASI), and oxygen green line (PASI and ERWIN2). The viewing locations and specific emissions of the various instruments differ. Nevertheless, the co-location of these instruments provides an excellent opportunity for case studies of specific events and for intercomparison between the different techniques. In this paper we discuss the approach we are using to combine observations from the different instruments. Case studies show that at times the various instruments are in good agreement but at other times they differ. Of particular interest are situations where gravity wave signatures are evident for an extended period of time and one such situation is presented. The discussion includes consideration of the filtering effect of viewing through airglow layers and the extent to which wind, airglow and temperature variations can be associated with the same gravity wave.

Myxosporean parasites of marine fishes: their distribution in the world's oceans.

PubMed

MacKenzie, K; Kalavati, C

2014-11-01

Myxosporeans are among the most common parasites of marine fish. Their economic importance is mainly as pathogens of both wild and farmed fish, but they have also been used as biological tags in population studies of their fish hosts. Here we review the literature and show the distribution of different families of Myxosporea infecting marine fishes in the world's oceans - the North Atlantic, South Atlantic, North Pacific, South Pacific and Indian. We also analyse their distribution in different orders of marine fishes. New families, genera and species of marine Myxosporea are continually being described and many more await description. Some regions, in particular the North Atlantic, have been more thoroughly investigated than others, so the analyses we present may not reflect the true distributions and we acknowledge that these may change considerably as other regions are investigated more fully. The distribution of myxosporean families in different taxonomic groups of marine fishes can indicate phylogenetic relationships between parasite and host and suggest the origins of different myxosporean taxa. We present some examples, while recognizing that new molecular information on phylogenetic relationships within the Myxozoa will lead to major changes in classification.

Frequency Dependent Non- Thermal Effects of Oscillating Electric Fields in the Microwave Region on the Properties of a Solvated Lysozyme System: A Molecular Dynamics Study

PubMed Central

Floros, Stelios; Liakopoulou-Kyriakides, Maria; Karatasos, Kostas

2017-01-01

The use of microwaves in every day’s applications raises issues regarding the non thermal biological effects of microwaves. In this work we employ molecular dynamics simulations to advance further the dielectric studies of protein solutions in the case of lysozyme, taking into consideration possible frequency dependent changes in the structural and dynamic properties of the system upon application of electric field in the microwave region. The obtained dielectric spectra are identical with those derived in our previous work using the Fröhlich-Kirkwood approach in the framework of the linear response theory. Noticeable structural changes in the protein have been observed only at frequencies near its absorption maximum. Concerning Cα position fluctuations, different frequencies affected different regions of the protein sequence. Furthermore, the influence of the field on the kinetics of protein-water as well as on the water-water hydrogen bonds in the first hydration shell has been studied; an extension of the Luzar-Chandler kinetic model was deemed necessary for a better fit of the applied field results and for the estimation of more accurate hydrogen bond lifetime values. PMID:28129348

Detecting insect pollinator declines on regional and global scales

USGS Publications Warehouse

Lubuhn, Gretchen; Droege, Sam; Connor, Edward F.; Gemmill-Herren, Barbara; Potts, Simon G.; Minckley, Robert L.; Griswold, Terry; Jean, Robert; Kula, Emanuel; Roubik, David W.; Cane, Jim; Wright, Karen W.; Frankie, Gordon; Parker, Frank

2013-01-01

Recently there has been considerable concern about declines in bee communities in agricultural and natural habitats. The value of pollination to agriculture, provided primarily by bees, is >$200 billion/year worldwide, and in natural ecosystems it is thought to be even greater. However, no monitoring program exists to accurately detect declines in abundance of insect pollinators; thus, it is difficult to quantify the status of bee communities or estimate the extent of declines. We used data from 11 multiyear studies of bee communities to devise a program to monitor pollinators at regional, national, or international scales. In these studies, 7 different methods for sampling bees were used and bees were sampled on 3 different continents. We estimated that a monitoring program with 200-250 sampling locations each sampled twice over 5 years would provide sufficient power to detect small (2-5%) annual declines in the number of species and in total abundance and would cost U.S.$2,000,000. To detect declines as small as 1% annually over the same period would require >300 sampling locations. Given the role of pollinators in food security and ecosystem function, we recommend establishment of integrated regional and international monitoring programs to detect changes in pollinator communities.

Sampling and Homogenization Strategies Significantly Influence the Detection of Foodborne Pathogens in Meat.

PubMed

Rohde, Alexander; Hammerl, Jens Andre; Appel, Bernd; Dieckmann, Ralf; Al Dahouk, Sascha

2015-01-01

Efficient preparation of food samples, comprising sampling and homogenization, for microbiological testing is an essential, yet largely neglected, component of foodstuff control. Salmonella enterica spiked chicken breasts were used as a surface contamination model whereas salami and meat paste acted as models of inner-matrix contamination. A systematic comparison of different homogenization approaches, namely, stomaching, sonication, and milling by FastPrep-24 or SpeedMill, revealed that for surface contamination a broad range of sample pretreatment steps is applicable and loss of culturability due to the homogenization procedure is marginal. In contrast, for inner-matrix contamination long treatments up to 8 min are required and only FastPrep-24 as a large-volume milling device produced consistently good recovery rates. In addition, sampling of different regions of the spiked sausages showed that pathogens are not necessarily homogenously distributed throughout the entire matrix. Instead, in meat paste the core region contained considerably more pathogens compared to the rim, whereas in the salamis the distribution was more even with an increased concentration within the intermediate region of the sausages. Our results indicate that sampling and homogenization as integral parts of food microbiology and monitoring deserve more attention to further improve food safety.

Sampling and Homogenization Strategies Significantly Influence the Detection of Foodborne Pathogens in Meat

PubMed Central

Rohde, Alexander; Hammerl, Jens Andre; Appel, Bernd; Dieckmann, Ralf; Al Dahouk, Sascha

2015-01-01

Efficient preparation of food samples, comprising sampling and homogenization, for microbiological testing is an essential, yet largely neglected, component of foodstuff control. Salmonella enterica spiked chicken breasts were used as a surface contamination model whereas salami and meat paste acted as models of inner-matrix contamination. A systematic comparison of different homogenization approaches, namely, stomaching, sonication, and milling by FastPrep-24 or SpeedMill, revealed that for surface contamination a broad range of sample pretreatment steps is applicable and loss of culturability due to the homogenization procedure is marginal. In contrast, for inner-matrix contamination long treatments up to 8 min are required and only FastPrep-24 as a large-volume milling device produced consistently good recovery rates. In addition, sampling of different regions of the spiked sausages showed that pathogens are not necessarily homogenously distributed throughout the entire matrix. Instead, in meat paste the core region contained considerably more pathogens compared to the rim, whereas in the salamis the distribution was more even with an increased concentration within the intermediate region of the sausages. Our results indicate that sampling and homogenization as integral parts of food microbiology and monitoring deserve more attention to further improve food safety. PMID:26539462

Benzene patterns in different urban environments and a prediction model for benzene rates based on NOx values

NASA Astrophysics Data System (ADS)

Paz, Shlomit; Goldstein, Pavel; Kordova-Biezuner, Levana; Adler, Lea

2017-04-01

Exposure to benzene has been associated with multiple severe impacts on health. This notwithstanding, at most monitoring stations, benzene is not monitored on a regular basis. The aims of the study were to compare benzene rates in different urban environments (region with heavy traffic and industrial region), to analyse the relationship between benzene and meteorological parameters in a Mediterranean climate type, to estimate the linkages between benzene and NOx and to suggest a prediction model for benzene rates based on NOx levels in order contribute to a better estimation of benzene. Data were used from two different monitoring stations, located on the eastern Mediterranean coast: 1) a traffic monitoring station in Tel Aviv, Israel (TLV) located in an urban region with heavy traffic; 2) a general air quality monitoring station in Haifa Bay (HIB), located in Israel's main industrial region. At each station, hourly, daily, monthly, seasonal, and annual data of benzene, NOx, mean temperature, relative humidity, inversion level, and temperature gradient were analysed over three years: 2008, 2009, and 2010. A prediction model for benzene rates based on NOx levels (which are monitored regularly) was developed to contribute to a better estimation of benzene. The severity of benzene pollution was found to be considerably higher at the traffic monitoring station (TLV) than at the general air quality station (HIB), despite the location of the latter in an industrial area. Hourly, daily, monthly, seasonal, and annual patterns have been shown to coincide with anthropogenic activities (traffic), the day of the week, and atmospheric conditions. A strong correlation between NOx and benzene allowed the development of a prediction model for benzene rates, based on NOx, the day of the week, and the month. The model succeeded in predicting the benzene values throughout the year (except for September). The severity of benzene pollution was found to be considerably higher at the traffic station (TLV) than at the general air quality station (HIB), despite being located in an industrial area. Hourly, daily, seasonal, and annual patterns of benzene rates have been shown to coincide with anthropogenic activities (traffic), day of the week, and atmospheric conditions. A prediction model for benzene rates was developed, based on NOx, the day of the week, and the month. The model suggested in this study might be useful for identifying potential risk of benzene in other urban environments.

Jupiter's High-Altitude Clouds

NASA Technical Reports Server (NTRS)

2007-01-01

The New Horizons Multispectral Visible Imaging Camera (MVIC) snapped this incredibly detailed picture of Jupiter's high-altitude clouds starting at 06:00 Universal Time on February 28, 2007, when the spacecraft was only 2.3 million kilometers (1.4 million miles) from the solar system's largest planet. Features as small as 50 kilometers (30 miles) are visible. The image was taken through a narrow filter centered on a methane absorption band near 890 nanometers, a considerably redder wavelength than what the eye can see. Images taken through this filter preferentially pick out clouds that are relatively high in the sky of this gas giant planet because sunlight at the wavelengths transmitted by the filter is completely absorbed by the methane gas that permeates Jupiter's atmosphere before it can reach the lower clouds.

The image reveals a range of diverse features. The south pole is capped with a haze of small particles probably created by the precipitation of charged particles into the polar regions during auroral activity. Just north of the cap is a well-formed anticyclonic vortex with rising white thunderheads at its core. Slightly north of the vortex are the tendrils of some rather disorganized storms and more pinpoint-like thunderheads. The dark 'measles' that appear a bit farther north are actually cloud-free regions where light is completely absorbed by the methane gas and essentially disappears from view. The wind action considerably picks up in the equatorial regions where giant plumes are stretched into a long wave pattern. Proceeding north of the equator, cirrus-like clouds are shredded by winds reaching speeds of up to 400 miles per hour, and more pinpoint-like thunderheads are visible. Although some of the famous belt and zone structure of Jupiter's atmosphere is washed out when viewed at this wavelength, the relatively thin North Temperate Belt shows up quite nicely, as does a series of waves just north of the belt. The north polar region of Jupiter in this image has a mottled appearance, and the scene is not as dynamic as the equatorial and south polar regions.

The intricate structures revealed in this image are exciting, but they are only part of the story. The New Horizons instruments have taken images of Jupiter at approximately 260 different wavelengths, providing essentially a three-dimensional view of Jupiter's atmosphere, since images at different wavelengths probe different altitudes. New Horizons is providing a wealth of data on this fascinating planet during this last close-up view of Jupiter until the middle of the next decade.

RNA-seq reveals a diminished acclimation response to the combined effects of ocean acidification and elevated seawater temperature in Pagothenia borchgrevinki.

PubMed

Huth, Troy J; Place, Sean P

2016-08-01

The IPCC has reasserted the strong influence of anthropogenic CO2 contributions on global climate change and highlighted the polar-regions as highly vulnerable. With these predictions the cold adapted fauna endemic to the Southern Ocean, which is dominated by fishes of the sub-order Notothenioidei, will face considerable challenges in the near future. Recent physiological studies have demonstrated that the synergistic stressors of elevated temperature and ocean acidification have a considerable, although variable, impact on notothenioid fishes. The present study explored the transcriptomic response of Pagothenia borchgrevinki to increased temperatures and pCO2 after 7, 28 and 56days of acclimation. We compared this response to short term studies assessing heat stress alone and foretell the potential impacts of these stressors on P. borchgrevinki's ability to survive a changing Southern Ocean. P. borchgrevinki did demonstrate a coordinated stress response to the dual-stressor condition, and even indicated that some level of inducible heat shock response may be conserved in this notothenioid species. However, the stress response of P. borchgrevinki was considerably less robust than that observed previously in the closely related notothenioid, Trematomus bernacchii, and varied considerably when compared across different acclimation time-points. Furthermore, the molecular response of these fish under multiple stressors displayed distinct differences compared to their response to short term heat stress alone. When exposed to increased sea surface temperatures, combined with ocean acidification, P. borchgrevinki demonstrated a coordinated stress response that has already peaked by 7days of acclimation and quickly diminished over time. However, this response is less dramatic than other closely related notothenioids under identical conditions, supporting previous research suggesting that this notothenioid species is less sensitive to environmental variation. Copyright © 2016 Elsevier B.V. All rights reserved.

The Viscoelastic Effect of Triggered Earthquakes in Various Tectonic Regions On a Global Scale

NASA Astrophysics Data System (ADS)

Sunbul, F.

2015-12-01

The relation between static stress changes and earthquake triggering has important implications for seismic hazard analysis. Considering long time difference between triggered events, viscoelastic stress transfer plays an important role in stress accumulation along the faults. Developing a better understanding of triggering effects may contribute to improvement of quantification of seismic hazard in tectonically active regions. Parsons (2002) computed the difference between the rate of earthquakes occurring in regions where shear stress increased and those regions where the shear stress decreased on a global scale. He found that 61% of the earthquakes occurred in regions with a shear stress increase, while 39% of events occurred in areas of shear stress decrease. Here, we test whether the inclusion of viscoelastic stress transfer affects the results obtained by Parsons (2002) for static stress transfer. Doing such a systematic analysis, we use Global Centroid Moment Tensor (CMT) catalog selecting 289 Ms>7 main shocks with their ~40.500 aftershocks located in ±2° circles for 5 years periods. For the viscoelastic post seismic calculations, we adapt 12 different published rheological models for 5 different tectonic regions. In order to minimise the uncertainties in this CMT catalog, we use the Frohlich and Davis (1999) statistical approach simultaneously. Our results shows that the 5590 aftershocks are triggered by the 289 Ms>7 earthquakes. 3419 of them are associated with calculated shear stress increase, while 2171 are associated with shear stress decrease. The summation of viscoelastic stress shows that, of the 5840 events, 3530 are associated with shear stress increases, and 2312 with shear stress decrease. This result shows an average 4.5% increase in total, the rate of increase in positive and negative areas are 3.2% and 6.5%, respectively. Therefore, over long time periods viscoelastic relaxation represents a considerable contribution to the total stress on neighbouring faults.

Impact of inter-seasonal solar variability on the association of lower troposphere and cold point tropopause in the tropics: Observations using RO data from COSMIC

NASA Astrophysics Data System (ADS)

Kumar, V.; Dhaka, S. K.; Ho, Shu-Peng; Singh, Narendra; Singh, Vir; Reddy, K. K.; Chun, H.-Y.

2017-12-01

Association of lower tropospheric variations with the cold point tropopause (CPT) is examined on inter-seasonal basis over the tropical region (30°N-30°S) during 2007-2010 using COSMIC/FORMOST-3 Radio Occultation (RO) data. Temperature analyses for this association are shown over different regions of the globe having contrast topography namely over Western Pacific sector, Indian sector, and African sector. Correlation coefficient (r), taken as a measurement of association, show specific longitudinal differences between the lower troposphere (from 1 km to 5 km height) and the CPT. The northern and southern hemispheres show contrast coupling of temperature variation between lower tropospheric region and the CPT. Land and ocean effects are found to contribute in a different way to the correlation coefficient. Analyses show symmetrical structure of 'r' on both sides of the equator over the African region, as data include mostly land region on both side of equator. Data represent positive correlation (r 0.5) over 15°-20° latitudes on either side of the equator over the African region, suggesting strong hold of the inter-seasonal variation of solar diabatic heating influence over the tropic of Cancer and tropic of Capricorn. On the other hand, there is a contrast behaviour over the Indian region, 'r' is nearly negative ( - 1.0) each year in the southern hemisphere (SH) and positive ( 0.4) in the northern hemisphere (NH) with a maxima near tropic of Cancer. Western Pacific region is found to display a linear increase in 'r' from negative ( - 1.0) in SH to positive ( 0.8) in NH. In general, 'r' (positive) maximizes over the land region around 15°-20° latitudes, suggesting a control of in phase inter-seasonal solar heating on the coupling of boundary layer/lower troposphere and CPT region, whereas it turns negative over water body. Analyses suggest that variabilities in CPT over different regions of globe show significant inter-seasonal association with the lower troposphere. Thus CPT variabilities are not only governed by QBO, ENSO, gravity waves and Kelvin wave system as reported in earlier studies but also considerably affected by inter-seasonal changes taking place in the lower troposphere.

Virtual Water Trade: Revisiting the Assessments to Incorporate Regional Water Stress

NASA Astrophysics Data System (ADS)

Perveen, S.; Puma, M. J.; Troy, T. J.; Browne, M.; Ghosh, M.

2011-12-01

Virtual water (VW) refers to the volume of freshwater embedded in the production and shipment of a commodity, which can include agricultural or industrial products, and the trade of commodities can then be viewed as the trade of one region's water resources to another. The premise behind this trade is that countries with a comparative water advantage may choose to export crops, and countries with scarce water resources may focus economic activity on non-water intensive sectors. However, this assumption is not always true given food self-sufficiency policies; water scarce regions often choose to unsustainably mine aquifers for irrigation. Recent studies have shown no correlation between dependency on VW imports and water scarcity for nations, suggesting that politico-economic considerations rather than resource scarcity considerations may dominate the current VW dynamics. Existing VW computations do not take into account water-scarcity value or the full-cost pricing of commodities. This study aims to fill in this gap by focusing on three countries - the United States, India, and Japan - and their production, imports and exports of crop, livestock and industrial commodities. These countries offer three different perspectives on virtual water, with Japan as a net importer of agriculture virtual water and a major industrial nation. The United States, on the other hand, exports significant quantities of grain. India is a developing country with a strong focus on food self-sufficiency. We first quantify the amount of water used in the production of each commodity and then examine the virtual water trade balance for each country, examining the tradeoffs each country has made between agriculture and industrial water use; given that water resources are finite. To examine the interplay between virtual water trade and water scarcity, we focus on two sub-regions, the Ogallala Aquifer in the US and the Punjab region in India, both of which have significant agricultural economies and are knowingly depleting their groundwater resources. We estimate the direct and indirect cost of water in each region and evaluate the economic trade-offs these regions are making.

Synoptic controls on precipitation pathways and snow delivery to high-accumulation ice core sites in the Ross Sea region, Antarctica

NASA Astrophysics Data System (ADS)

Sinclair, K. E.; Bertler, N. A. N.; Trompetter, W. J.

2010-11-01

Dominant storm tracks to two ice core sites on the western margin of the Ross Sea, Antarctica (Skinner Saddle (SKS) and Evans Piedmont Glacier), are investigated to establish key synoptic controls on snow accumulation. This is critical in terms of understanding the seasonality, source regions, and transport pathways of precipitation delivered to these sites. In situ snow depth and meteorological observations are used to identify major accumulation events in 2007-2008, which differ considerably between sites in terms of their magnitude and seasonal distribution. While snowfall at Evans Piedmont Glacier occurs almost exclusively during summer and spring, Skinner Saddle receives precipitation year round with a lull during the months of April and May. Cluster analysis of daily back trajectories reveals that the highest-accumulation days at both sites result from fast-moving air masses, associated with synoptic-scale low-pressure systems. There is evidence that short-duration pulses of snowfall at SKS also originate from mesocyclone development over the Ross Ice Shelf and local moisture sources. Changes in the frequency and seasonal distribution of these mechanisms of precipitation delivery will have a marked impact on annual accumulation over time and will therefore need careful consideration during the interpretation of stable isotope and geochemical records from these ice cores.

Divergence of dominant factors in soil microbial communities and functions in forest ecosystems along a climatic gradient

NASA Astrophysics Data System (ADS)

Xu, Zhiwei; Yu, Guirui; Zhang, Xinyu; He, Nianpeng; Wang, Qiufeng; Wang, Shengzhong; Xu, Xiaofeng; Wang, Ruili; Zhao, Ning

2018-03-01

Soil microorganisms play an important role in regulating nutrient cycling in terrestrial ecosystems. Most of the studies conducted thus far have been confined to a single forest biome or have focused on one or two controlling factors, and few have dealt with the integrated effects of climate, vegetation, and soil substrate availability on soil microbial communities and functions among different forests. In this study, we used phospholipid-derived fatty acid (PLFA) analysis to investigate soil microbial community structure and extracellular enzymatic activities to evaluate the functional potential of soil microbes of different types of forests in three different climatic zones along the north-south transect in eastern China (NSTEC). Both climate and forest type had significant effects on soil enzyme activities and microbial communities with considerable interactive effects. Except for soil acid phosphatase (AP), the other three enzyme activities were much higher in the warm temperate zone than in the temperate and the subtropical climate zones. The soil total PLFAs and bacteria were much higher in the temperate zone than in the warm temperate and the subtropical zones. The soil β-glucosidase (BG) and N-acetylglucosaminidase (NAG) activities were highest in the coniferous forest. Except for the soil fungi and fungi-bacteria (F/B), the different groups of microbial PLFAs were much higher in the conifer broad-leaved mixed forests than in the coniferous forests and the broad-leaved forests. In general, soil enzyme activities and microbial PLFAs were higher in primary forests than in secondary forests in temperate and warm temperate regions. In the subtropical region, soil enzyme activities were lower in the primary forests than in the secondary forests and microbial PLFAs did not differ significantly between primary and secondary forests. Different compositions of the tree species may cause variations in soil microbial communities and enzyme activities. Our results showed that the main controls on soil microbes and functions vary in different climatic zones and that the effects of soil moisture content, soil temperature, clay content, and the soil N / P ratio were considerable. This information will add value to the modeling of microbial processes and will contribute to carbon cycling in large-scale carbon models.

Projecting Heat-Related Mortality Impacts Under a Changing Climate in the New York City Region

PubMed Central

Knowlton, Kim; Lynn, Barry; Goldberg, Richard A.; Rosenzweig, Cynthia; Hogrefe, Christian; Rosenthal, Joyce Klein; Kinney, Patrick L.

2007-01-01

Objectives. We sought to project future impacts of climate change on summer heat-related premature deaths in the New York City metropolitan region. Methods. Current and future climates were simulated over the northeastern United States with a global-to-regional climate modeling system. Summer heat-related premature deaths in the 1990s and 2050s were estimated by using a range of scenarios and approaches to modeling acclimatization (e.g., increased use of air conditioning, gradual physiological adaptation). Results. Projected regional increases in heat-related premature mortality by the 2050s ranged from 47% to 95%, with a mean 70% increase compared with the 1990s. Acclimatization effects reduced regional increases in summer heat-related premature mortality by about 25%. Local impacts varied considerably across the region, with urban counties showing greater numbers of deaths and smaller percentage increases than less-urbanized counties. Conclusions. Although considerable uncertainty exists in climate forecasts and future health vulnerability, the range of projections we developed suggests that by midcentury, acclimatization may not completely mitigate the effects of climate change in the New York City metropolitan region, which would result in an overall net increase in heat-related premature mortality. PMID:17901433

[Clinical examination of the hip joint in adults].

PubMed

Grifka, J; Keshmiri, A; Maderbacher, G; Craiovan, B

2014-12-01

Complaints in the region of the hips and pelvis are often difficult to classify. This is due to the fact that pain projection and overlapping can occur; therefore, the complete region of the lumbar spine, pelvis and hips must be considered as a single entity in which alterations can result in radiation throughout the whole region. There are many different anatomical structures within the pelvic region so that the function of various muscle components can be impaired and cause pathological alterations to positional relationships of bony structures or even alterations to other soft tissues, such as ligaments, tendons and labra. In terms of differential diagnostics the groin must be seen as the weak point of the peritoneum and vascular system and taken into consideration. Therefore, a detailed and targeted medical history, functional testing and specific examinations and tests are necessary to narrow down the pathology in question and reach a definitive diagnosis. Orthopedic surgeons must know which conspicuous features can lead to which problems and which anatomical structures are likely to be affected by irritation. The results of the clinical examination are the basis for targeted imaging diagnostics and subsequent therapy.

[Clinical examination of the hip joint in adults].

PubMed

Grifka, J; Keshmiri, A; Maderbacher, G; Craiovan, B

2015-07-01

Complaints in the region of the hips and pelvis are often difficult to classify. This is due to the fact that pain projection and overlapping can occur; therefore, the complete region of the lumbar spine, pelvis and hips must be considered as a single entity in which alterations can result in radiation throughout the whole region. There are many different anatomical structures within the pelvic region so that the function of various muscle components can be impaired and cause pathological alterations to positional relationships of bony structures or even alterations to other soft tissues, such as ligaments, tendons and labra. In terms of differential diagnostics the groin must be seen as the weak point of the peritoneum and vascular system and taken into consideration. Therefore, a detailed and targeted medical history, functional testing and specific examinations and tests are necessary to narrow down the pathology in question and reach a definitive diagnosis. Orthopedic surgeons must know which conspicuous features can lead to which problems and which anatomical structures are likely to be affected by irritation. The results of the clinical examination are the basis for targeted imaging diagnostics and subsequent therapy.

Do clinical manifestations of Systemic Lupus Erythematosus in Pakistan correlate with rest of Asia?

PubMed

Rabbani, Malik Anas; Siddiqui, Bilal Karim; Tahir, Muhammad Hammad; Ahmad, Bushra; Shamim, A; Majid, Shahid; Ali, Syed Sohail; Shah, Syed Mansoor Ahmed; Ahmad, Aasim

2006-05-01

Systemic Lupus Erythematosus (SLE) is known to be different among people with different racial, geographical and socio-economic back grounds. Asia has diverse ethnic groups broadly, Orientals in the East and Southeast Asia, Indians in South Asia and Arabs in the Middle East. These regions differ significantly from the Caucasians with reference to SLE. The purpose of this study was, therefore, to delineate the clinical pattern and disease course in Pakistani patients with SLE and compare it with Asian data. Patients with SLE fulfilling the clinical and laboratory criteria of the American Rheumatism Association admitted at the Aga Khan University Hospital between 1986 and 2001 were studied by means of a retrospective review of their records. The results were compared with various studies in different regions of Asia. Demographically, it was seen that SLE is a disease predominantly of females in their third decade, which is generally consistent with Asian data. There was less cutaneous manifestations, arthritis, serositis, haematological and renal involvement compared to various regions in Asia. The neurological manifestations of SLE, however, place Pakistani patients in the middle of a spectrum between South Asians and other Asian races. This study has shown that the clinical characteristics of SLE patients in our country may be different to those of other Asian races. Although our population is similar to South Asians, but clinical manifestations of our SLE patients are considerably different, suggesting some unknown etiology. Further studies are required to confirm the above results and to find statistically sounder associations.

Contribution of health workforce to health outcomes: empirical evidence from Vietnam.

PubMed

Nguyen, Mai Phuong; Mirzoev, Tolib; Le, Thi Minh

2016-11-16

In Vietnam, a lower-middle income country, while the overall skill- and knowledge-based quality of health workforce is improving, health workers are disproportionately distributed across different economic regions. A similar trend appears to be in relation to health outcomes between those regions. It is unclear, however, whether there is any relationship between the distribution of health workers and the achievement of health outcomes in the context of Vietnam. This study examines the statistical relationship between the availability of health workers and health outcomes across the different economic regions in Vietnam. We constructed a panel data of six economic regions covering 8 years (2006-2013) and used principal components analysis regressions to estimate the impact of health workforce on health outcomes. The dependent variables representing the outcomes included life expectancy at birth, infant mortality, and under-five mortality rates. Besides the health workforce as our target explanatory variable, we also controlled for key demographic factors including regional income per capita, poverty rate, illiteracy rate, and population density. The numbers of doctors, nurses, midwives, and pharmacists have been rising in the country over the last decade. However, there are notable differences across the different categories. For example, while the numbers of nurses increased considerably between 2006 and 2013, the number of pharmacists slightly decreased between 2011 and 2013. We found statistically significant evidence of the impact of density of doctors, nurses, midwives, and pharmacists on improvement to life expectancy and reduction of infant and under-five mortality rates. Availability of different categories of health workforce can positively contribute to improvements in health outcomes and ultimately extend the life expectancy of populations. Therefore, increasing investment into more equitable distribution of four main categories of health workforce (doctors, nurses, midwives, and pharmacists) can be an important strategy for improving health outcomes in Vietnam and other similar contexts. Future interventions will also need to consider an integrated approach, building on the link between the health and the development.

Assimilating bio-optical glider data during a phytoplankton bloom in the southern Ross Sea

NASA Astrophysics Data System (ADS)

Kaufman, Daniel E.; Friedrichs, Marjorie A. M.; Hemmings, John C. P.; Smith, Walker O., Jr.

2018-01-01

The Ross Sea is a region characterized by high primary productivity in comparison to other Antarctic coastal regions, and its productivity is marked by considerable variability both spatially (1-50 km) and temporally (days to weeks). This variability presents a challenge for inferring phytoplankton dynamics from observations that are limited in time or space, which is often the case due to logistical limitations of sampling. To better understand the spatiotemporal variability in Ross Sea phytoplankton dynamics and to determine how restricted sampling may skew dynamical interpretations, high-resolution bio-optical glider measurements were assimilated into a one-dimensional biogeochemical model adapted for the Ross Sea. The assimilation of data from the entire glider track using the micro-genetic and local search algorithms in the Marine Model Optimization Testbed improves the model-data fit by ˜ 50 %, generating rates of integrated primary production of 104 g C m-2 yr-1 and export at 200 m of 27 g C m-2 yr-1. Assimilating glider data from three different latitudinal bands and three different longitudinal bands results in minimal changes to the simulations, improves the model-data fit with respect to unassimilated data by ˜ 35 %, and confirms that analyzing these glider observations as a time series via a one-dimensional model is reasonable on these scales. Whereas assimilating the full glider data set produces well-constrained simulations, assimilating subsampled glider data at a frequency consistent with cruise-based sampling results in a wide range of primary production and export estimates. These estimates depend strongly on the timing of the assimilated observations, due to the presence of high mesoscale variability in this region. Assimilating surface glider data subsampled at a frequency consistent with available satellite-derived data results in 40 % lower carbon export, primarily resulting from optimized rates generating more slowly sinking diatoms. This analysis highlights the need for the strategic consideration of the impacts of data frequency, duration, and coverage when combining observations with biogeochemical modeling in regions with strong mesoscale variability.

Key Ethical Issues Discussed at CDC-Sponsored International, Regional Meetings to Explore Cultural Perspectives and Contexts on Pandemic Influenza Preparedness and Response

PubMed Central

Lor, Aun; Thomas, James C.; Barrett, Drue H.; Ortmann, Leonard W.; Herrera Guibert, Dionisio J.

2016-01-01

Background: Recognizing the importance of having a broad exploration of how cultural perspectives may shape thinking about ethical considerations, the Centers for Disease Control and Prevention (CDC) funded four regional meetings in Africa, Asia, Latin America, and the Eastern Mediterranean to explore these perspectives relevant to pandemic influenza preparedness and response. The meetings were attended by 168 health professionals, scientists, academics, ethicists, religious leaders, and other community members representing 40 countries in these regions. Methods: We reviewed the meeting reports, notes and stories and mapped outcomes to the key ethical challenges for pandemic influenza response described in the World Health Organization’s (WHO’s) guidance, Ethical Considerations in Developing a Public Health Response to Pandemic Influenza: transparency and public engagement, allocation of resources, social distancing, obligations to and of healthcare workers, and international collaboration. Results: The important role of transparency and public engagement were widely accepted among participants. However, there was general agreement that no "one size fits all" approach to allocating resources can address the variety of economic, cultural and other contextual factors that must be taken into account. The importance of social distancing as a tool to limit disease transmission was also recognized, but the difficulties associated with this measure were acknowledged. There was agreement that healthcare workers often have competing obligations and that government has a responsibility to assist healthcare workers in doing their job by providing appropriate training and equipment. Finally, there was agreement about the importance of international collaboration for combating global health threats. Conclusion: Although some cultural differences in the values that frame pandemic preparedness and response efforts were observed, participants generally agreed on the key ethical principles discussed in the WHO’s guidance. Most significantly the input gathered from these regional meetings pointed to the important role that procedural ethics can play in bringing people and countries together to respond to the shared health threat posed by a pandemic influenza despite the existence of cultural differences. PMID:27801360

A Mixed Methods Study of Participant Reaction to Domestic Violence Research in Jordan

ERIC Educational Resources Information Center

Clark, Cari Jo; Shahrouri, Manal; Halasa, Louma; Khalaf, Inaam; Spencer, Rachael; Everson-Rose, Susan

2012-01-01

Research on domestic violence against women has increased considerably over the past few decades. Most participants in such studies find the exercise worthwhile and of greater benefit than emotional cost; however, systematic examination of participant reaction to research on violence is considerably lacking, especially in the Middle East region.…

Interactive calculation procedure for supersonic flows. Ph.D. Thesis - Case Western Reserve Univ., 1976. Final Report

NASA Technical Reports Server (NTRS)

Tassa, Y.; Anderson, B. H.; Reshotko, E.

1977-01-01

An interactive procedure was developed for supersonic viscous flows that can be used for either two-dimensional or axisymmetric configurations. The procedure is directed to supersonic internal flows as well as those supersonic external flows that require consideration of mutual interaction between the outer flow and the boundary layer flow. The flow field is divided into two regions: an inner region which is highly viscous and mostly subsonic and an outer region where the flow is supersonic and in which viscous effects are small but not negligible. For the outer region a numerical solution is obtained by applying the method of characteristics to a system of equations which includes viscous and conduction transport terms only normal to the streamlines. The inner region is treated by a system of equations of the boundary layer type that includes higher order effects such as longitudinal and transverse curvature and normal pressure gradients. These equations are coupled and solved simultaneously in the physical coordinates by using an implicit finite difference scheme. This system can also be used to calculate laminar and turbulent boundary layers using a scalar eddy viscosity concept.

An improved DPSM technique for modelling ultrasonic fields in cracked solids

NASA Astrophysics Data System (ADS)

Banerjee, Sourav; Kundu, Tribikram; Placko, Dominique

2007-04-01

In recent years Distributed Point Source Method (DPSM) is being used for modelling various ultrasonic, electrostatic and electromagnetic field modelling problems. In conventional DPSM several point sources are placed near the transducer face, interface and anomaly boundaries. The ultrasonic or the electromagnetic field at any point is computed by superimposing the contributions of different layers of point sources strategically placed. The conventional DPSM modelling technique is modified in this paper so that the contributions of the point sources in the shadow region can be removed from the calculations. For this purpose the conventional point sources that radiate in all directions are replaced by Controlled Space Radiation (CSR) sources. CSR sources can take care of the shadow region problem to some extent. Complete removal of the shadow region problem can be achieved by introducing artificial interfaces. Numerically synthesized fields obtained by the conventional DPSM technique that does not give any special consideration to the point sources in the shadow region and the proposed modified technique that nullifies the contributions of the point sources in the shadow region are compared. One application of this research can be found in the improved modelling of the real time ultrasonic non-destructive evaluation experiments.

ASSESSING FISH TISSUE CONTAMINATION ON A REGIONAL SCALE

EPA Science Inventory

The selection of target fish species for assessing the extent of fish tissue contaminants is a critical consideration in regional stream surveys such as the Environmental Monitoring and Assessment Program (EMAP). The ideal species would be widely distributed and common, bioaccumu...

15 CFR 990.15 - Considerations to facilitate restoration.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., identify support services, identify natural resources and services at risk, identify area and regional... included in pre-incident planning to the fullest extent practicable. (b) Regional Restoration Plans. Where practicable, incident-specific restoration plan development is preferred, however, trustees may develop...

Coordinating State and Regional Transportation Safety Planning through the SHSP Process : an RSPCB Peer Exchange

DOT National Transportation Integrated Search

2013-01-01

Local and regional governments have important roles to play in identifying and addressing safety issues on roadways within their jurisdictions. Congress recognized this need and passed legislation in 1998 requiring safety consideration in transportat...

A Balance of Power?

ERIC Educational Resources Information Center

Mosey, Edward

1991-01-01

The booming economy of the Pacific Northwest region promotes the dilemma of balancing the need for increased electrical power with the desire to maintain that region's unspoiled natural environment. Pertinent factors discussed within the balance equation are population trends, economic considerations, industrial power requirements, and…

Use of models to map potential capture of surface water

USGS Publications Warehouse

Leake, Stanley A.

2006-01-01

The effects of ground-water withdrawals on surface-water resources and riparian vegetation have become important considerations in water-availability studies. Ground water withdrawn by a well initially comes from storage around the well, but with time can eventually increase inflow to the aquifer and (or) decrease natural outflow from the aquifer. This increased inflow and decreased outflow is referred to as “capture.” For a given time, capture can be expressed as a fraction of withdrawal rate that is accounted for as increased rates of inflow and decreased rates of outflow. The time frames over which capture might occur at different locations commonly are not well understood by resource managers. A ground-water model, however, can be used to map potential capture for areas and times of interest. The maps can help managers visualize the possible timing of capture over large regions. The first step in the procedure to map potential capture is to run a ground-water model in steady-state mode without withdrawals to establish baseline total flow rates at all sources and sinks. The next step is to select a time frame and appropriate withdrawal rate for computing capture. For regional aquifers, time frames of decades to centuries may be appropriate. The model is then run repeatedly in transient mode, each run with one well in a different model cell in an area of interest. Differences in inflow and outflow rates from the baseline conditions for each model run are computed and saved. The differences in individual components are summed and divided by the withdrawal rate to obtain a single capture fraction for each cell. Values are contoured to depict capture fractions for the time of interest. Considerations in carrying out the analysis include use of realistic physical boundaries in the model, understanding the degree of linearity of the model, selection of an appropriate time frame and withdrawal rate, and minimizing error in the global mass balance of the model.

Resolution of coi-dominant phytoplankton species in a eutrophiclake using synchrotron-based Fourier transform infraredspectroscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dean, A.P.; Martin, Michael C.; Sigee, D.C.

2006-10-09

Synchrotron-based Fourier-transform infrared (FTIR)microspectroscopy was used to distinguish micropopulations of thecodominant algae Microcystis aeruginosa (Cyanophyceae) and Ceratiumhirundinella (Dinophyceae) in mixed phytoplankton samples taken from thewater column of a stratified eutrophic lake (Rostherne Mere, UK). FTIRspectra of the two algae showed a closely similar sequence of 10 bandsover the wave-number range 4000-900 cm-1. These were assigned to a rangeof vibrationally active chemical groups using published band assignmentsand on the basis of correlation and factor analysis. In both algae,intracellular concentrations of macromolecular components (determined asband intensity) varied considerably within the same population,indicating substantial intraspecific heterogeneity. Interspecificdifferences were separately analysed in relation tomore » discrete bands and bymultivariate analysis of the entire spectral region 1750-900 cm-1. Interms of discrete bands, comparison of individual intensities (normalisedto amide 1) demonstrated significant (99 percent probability level)differences in relation to six bands between the two algal species. Keyinterspecific differences were also noted in relation to the positions ofbands 2, 10 (carbohydrate) and 7 (protein) and in the 3-D plots derivedby principal component analysis (PCA) of the sequence of bandintensities. PCA of entire spectral regions showed clear resolutionofspecies in the PCA plot, with indication of separation on the basis ofprotein (region 1700-1500 cm1) and carbohydrate (region 1150-900 cm1)composition in the loading plot. Hierarchical cluster analysis (Wardalgorithm) of entire spectral regions also showed clear discrimination ofthe two species within the resulting dendrogram.« less

The Nubium and Imbrium regions on the Moon: a history of mare flows

NASA Astrophysics Data System (ADS)

Bugiolacchi, Roberto

The objective of my research is to identify, classify, measure, date, and place in a geological context distinctive lava flows within the Nubium and Imbrium regions of the Moon. I used multispectral filter data from the Clementine mission to create regional compositional maps based on the estimated abundance of iron and titanium in the regolith. In addition, by letting the 415 nm, 950 nm, and 750 nm wavebands respectively control the BRG channels, I produced a 'stretched' true colour image. A 'false colour' map was also derived by combining the 415/750, 750/1000, and 750/415 nm ratios this type of image benefits from having albedo differences suppressed and colour differences considerably 'stretched'. Most of the exposed maria unit flows were thus identified, outlined, and classified according to their FeO and TiC2 weight percentage content. I also estimated the basalts' ages by establishing their crater size frequency distribution using Lunar Orbiter and Apollo images. A map produced from the filter ratio 750/950 nm helped identify late extrusive materials, fresh impact ejecta, and newly exposed regolith. Iron content variations in the ejecta blankets of several craters were used to estimate the area's minimum maria thickness at the time of impact. This work also focused on geological formations of outstanding interest related to the igneous history of regions. Finally, most data and results were collected and employed to produce multi-layered geological maps of the Nubium and Imbrium regions.

[Nutritional value of daily diets prepared in several regions of the country. Part VI. Value of retinol, beta-carotene and vitamin E].

PubMed

Nadolna, I; Okolska, G; Kunachowicz, H

1992-01-01

Determinations of retinol, beta-carotene and vitamin E were carried out in daily diets of manual and mental workers with medium incomes. The diets were prepared on the basis of the analysis of the Central Statistical Office in 1986 under laboratory conditions in five regions of Poland (Warszawa, Lublin, Olsztyn, Poznań, Wrocław). It was found that these diets contained respectively: vitamin A (retinol and beta-carotene) 844 and 859 micrograms, retinol 466 and 496 micrograms, beta-carotene 2267 and 2167 micrograms and vitamin E 4.82 and 5.12 mg per day. In relation to the realization of daily recommended dietary allowances by these diets, for vitamin A were met respectively 102 and 104% and for vitamin E 58 and 61%. There were considerable differences in the content of beta-carotene and vitamin E between diets prepared in all five regions of Poland.

Spectroscopic Characterization of Mineralogy Across Vesta: Evidence of Different Lithologies

NASA Technical Reports Server (NTRS)

De Sanotis, M. C.; Ammannito, E.; Filacchione, G.; Capria, M. T.; Tosi, F.; Capaccioni, F.; Zambon, F.; Carraro, F.; Fonte, S.; Frigeri, A.;

A view to the future of natural gas and electricity: An integrated modeling approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cole, Wesley J.; Medlock, Kenneth B.; Jani, Aditya

This paper demonstrates the value of integrating two highly spatially resolved models: the Rice World Gas Trade Model (RWGTM) of the natural gas sector and the Regional Energy Deployment System (ReEDS) model of the U.S. electricity sector. The RWGTM passes electricity-sector natural gas prices to the ReEDS model, while the ReEDS model returns electricity-sector natural gas demand to the RWGTM. The two models successfully converge to a solution under reference scenario conditions. We present electricity-sector and natural gas sector evolution using the integrated models for this reference scenario. This paper demonstrates that the integrated models produced similar national-level results asmore » when running in a stand-alone form, but that regional and state-level results can vary considerably. As we highlight, these regional differences have potentially significant implications for electric sector planners especially in the wake of substantive policy changes for the sector (e.g., the Clean Power Plan).« less

General practitioners' referrals to specialist outpatient clinics. II. Locations of specialist outpatient clinics to which general practitioners refer patients.

PubMed Central

Coulter, A.; Noone, A.; Goldacre, M.

1989-01-01

Although linkage by computer of hospital administration systems across all clinics in a health district is becoming a practical possibility, complete records of general practitioners' referrals to outpatient clinics will be difficult to achieve. Data from a large study of general practitioners' referrals to such clinics were used to calculate the proportion of referrals that crossed district boundaries, the proportion that were made to the private sector; and the number of locations that each practice referred patients to. Of the 17,601 referrals from practices in Oxford Regional Health Authority, 13,857 (78.7%) were made to NHS outpatient clinics within practices' own districts, 1524 (8.7%) to clinics in other districts in the same region, 420 (2.4%) to NHS clinics in other regions, and 1800 (10.2%) to the private sector; but these proportions varied considerably among the practices. The mean number of different NHS hospitals or clinics that each practice referred patients to was 15.8 (range 4-42). PMID:2504414

Growth and spread of manufacturing productivity across regions in India.

PubMed

Babu, Suresh M; Natarajan, Rajesh Raj S

2013-12-01

An expected outcome of economic reforms in India is enhanced pace of industrialization with manufacturing sector playing a crucial role by increasing its share in output via higher investments and increased productivity. This process of industrialization was also expected to usher in possibilities for the slow growing states to catch up with the fast growing ones. This paper assesses the extent of regional manufacturing performance in India by analyzing the trends in labour and total factor productivity for the organized manufacturing sector of 15 major Indian states. Data Envelopment Analysis is used to compute Malmquist total factor productivity index and its components. The results indicate that labour productivity diverges in the reform era and its growth and TFPG follow more or less a similar pattern. The study also finds that growth in productivity vary considerably across states and this variation in productivity growth can be explained, to a great extent, by differences in infrastructural development at the regional level. D24, O47, R11.

Innovative Production of Polyvinychloride on the Basis of Vertical Integration of Business and Cluster Organisation

NASA Astrophysics Data System (ADS)

Kudryashova, Irina; Zakharova, Natalia; Kharlampenkov, Evgeniy

2017-11-01

The paper presents the results of the research of the world and Russian market of polyvinyl chloride (PVC), a comparative assessment is made and the similarities and differences of these segments at the present have been identified. The theoretical possibility of considerable prospects of the development of domestic production of PVC is justified, ensure that it can achieve import substitution and export substitutionof this product in Russia. Based on the theoryof value chains and cluster organization of the enterprises of coal and chemical industries, ferrous metallurgy and other enterprises of Kuzbass have been proposed new technological solutions for the production of PVC, taking into account regional features of naturalresource base and capacity of national and world markets. It is established that the organization of production of PVC, using coal chemistry technology can be a promising growth point for the business of the Kemerovo region, will help to diversify the coal industry, to expand its product structure and export potential of the region, increase its competitiveness.

Long-Lead Prediction of the 2015 Fire and Haze Episode in Indonesia

NASA Astrophysics Data System (ADS)

Shawki, Dilshad; Field, Robert D.; Tippett, Michael K.; Saharjo, Bambang Hero; Albar, Israr; Atmoko, Dwi; Voulgarakis, Apostolos

2017-10-01

We conducted a case study of National Centers for Environmental Prediction Climate Forecast System version 2 seasonal model forecast performance over Indonesia in predicting the dry conditions in 2015 that led to severe fire, in comparison to the non-El Niño dry season conditions of 2016. Forecasts of the Drought Code (DC) component of Indonesia's Fire Danger Rating System were examined across the entire equatorial Asia region and for the primary burning regions within it. Our results show that early warning lead times of high observed DC in September and October 2015 varied considerably for different regions. High DC over Southern Kalimantan and Southern New Guinea were predicted with 180 day lead times, whereas Southern Sumatra had lead times of up to only 60 days, which we attribute to the absence in the forecasts of an eastward decrease in Indian Ocean sea surface temperatures. This case study provides the starting point for longer-term evaluation of seasonal fire danger rating forecasts over Indonesia.

A view to the future of natural gas and electricity: An integrated modeling approach

DOE PAGES

Cole, Wesley J.; Medlock, Kenneth B.; Jani, Aditya

2016-03-17

This paper demonstrates the value of integrating two highly spatially resolved models: the Rice World Gas Trade Model (RWGTM) of the natural gas sector and the Regional Energy Deployment System (ReEDS) model of the U.S. electricity sector. The RWGTM passes electricity-sector natural gas prices to the ReEDS model, while the ReEDS model returns electricity-sector natural gas demand to the RWGTM. The two models successfully converge to a solution under reference scenario conditions. We present electricity-sector and natural gas sector evolution using the integrated models for this reference scenario. This paper demonstrates that the integrated models produced similar national-level results asmore » when running in a stand-alone form, but that regional and state-level results can vary considerably. As we highlight, these regional differences have potentially significant implications for electric sector planners especially in the wake of substantive policy changes for the sector (e.g., the Clean Power Plan).« less

Applications of Skylab EREP photographs to mapping landforms and environmental geomorphology in the Great Plains and Midwest

NASA Technical Reports Server (NTRS)

Morrison, R. B.; Lineback, J. A.; Fuller, H. K.; Rinkenberger, R. K.

1975-01-01

The following evaluations of Skylab photographs were undertaken: (1) the 1290 Skylab S190A and S190B photographs of Illinois, Iowa, Kansas, Missouri, Nebraska, and South Dakota were evaluated in detail in terms of coverage, cloud cover, photographic quality, endlap, detectability of roads and stereorelief, and utility for geomorphologic mapping, and (2) the utility of the Skylab photos were tested for interpretive analytic mapping of geomorphologic features over large areas representative of different parts of this region. Photointerpretative maps of analytic geomorphology were obtained for various test areas representative of the varied landscapes in the region. These maps are useful for regional land-use planning, ground-water exploration, and other environmental geomorphologic-geologic applications. Compared with LANDSAT-1 MSS images, Skylab photos afford almost as extensive overviews of large areas but in considerably greater detail, and for many SL photos, moderate stereorelief. However, repetitive multiseasonal, cloud-free coverage by high-quality photos is very limited and many areas have no coverage at all.

Morphological rational operator for contrast enhancement.

PubMed

Peregrina-Barreto, Hayde; Herrera-Navarro, Ana M; Morales-Hernández, Luis A; Terol-Villalobos, Iván R

2011-03-01

Contrast enhancement is an important task in image processing that is commonly used as a preprocessing step to improve the images for other tasks such as segmentation. However, some methods for contrast improvement that work well in low-contrast regions affect good contrast regions as well. This occurs due to the fact that some elements may vanish. A method focused on images with different luminance conditions is introduced in the present work. The proposed method is based on morphological transformations by reconstruction and rational operations, which, altogether, allow a more accurate contrast enhancement resulting in regions that are in harmony with their environment. Furthermore, due to the properties of these morphological transformations, the creation of new elements on the image is avoided. The processing is carried out on luminance values in the u'v'Y color space, which avoids the creation of new colors. As a result of the previous considerations, the proposed method keeps the natural color appearance of the image.

Overweight and obesity in rural girls from Poland: changes between 1987 and 2001.

PubMed

Chrzanowska, Maria; Łaska-Mierzejewska, Teresa; Suder, Agnieszka

2013-03-01

Several studies have documented increased prevalence of overweight and obesity in inhabitants of rural regions, but determinants of their prevalence are complex and not always in one direction. The aim of this study was to estimate both the prevalence and extent of overweight and obesity among rural girls in Poland between 1987 and 2001, as well as to assess differentiation of the phenomenon between regions of different social structures. The data come from two series of cross-sectional studies; the first in 1987 included 7764 girls, and the second in 2001 included 9431 girls aged 9-18. Body mass index (according to the International Obesity Task Force, IOTF) and the EOW index (extent of overweight), which shows by what mean BMI value the overweight boundaries are exceeded, were calculated. Overweight and obesity prevalences in the whole sample, were, respectively, 14.9% and 2.7% in 1987 and 15.5% and 2.5% in 2001, but significant differentiation in the direction of the changes was observed between the examined regions. In one of them, characterized by sudden, mass and long-term unemployment, there was a considerable decrease in overweight and obesity prevalence, whereas in a relatively wealthier region no changes were observed during the 14-year period. Two other regions with a relatively low standard of living and low incomes and education status presented a significant increase in overweight and obesity prevalence. The EOW index increased from 1.9 to 2.1 in the whole examined sample, and it also confirmed significant differences in expansion of overweight and obesity between the examined regions. The complex character of political and socioeconomic changes in Poland during the 1990 s has resulted in two-directional changes in biological measures of living conditions. The analysis of the whole sample led to different results in comparison to separate analyses of each of the examined regions.

Role of mitochondrial calcium uptake homeostasis in resting state fMRI brain networks.

PubMed

Kannurpatti, Sridhar S; Sanganahalli, Basavaraju G; Herman, Peter; Hyder, Fahmeed

2015-11-01

Mitochondrial Ca(2+) uptake influences both brain energy metabolism and neural signaling. Given that brain mitochondrial organelles are distributed in relation to vascular density, which varies considerably across brain regions, we hypothesized different physiological impacts of mitochondrial Ca(2+) uptake across brain regions. We tested the hypothesis by monitoring brain "intrinsic activity" derived from the resting state functional MRI (fMRI) blood oxygen level dependent (BOLD) fluctuations in different functional networks spanning the somatosensory cortex, caudate putamen, hippocampus and thalamus, in normal and perturbed mitochondrial Ca(2+) uptake states. In anesthetized rats at 11.7 T, mitochondrial Ca(2+) uptake was inhibited or enhanced respectively by treatments with Ru360 or kaempferol. Surprisingly, mitochondrial Ca(2+) uptake inhibition by Ru360 and enhancement by kaempferol led to similar dose-dependent decreases in brain-wide intrinsic activities in both the frequency domain (spectral amplitude) and temporal domain (resting state functional connectivity; RSFC). The fact that there were similar dose-dependent decreases in the frequency and temporal domains of the resting state fMRI-BOLD fluctuations during mitochondrial Ca(2+) uptake inhibition or enhancement indicated that mitochondrial Ca(2+) uptake and its homeostasis may strongly influence the brain's functional organization at rest. Interestingly, the resting state fMRI-derived intrinsic activities in the caudate putamen and thalamic regions saturated much faster with increasing dosage of either drug treatment than the drug-induced trends observed in cortical and hippocampal regions. Regional differences in how the spectral amplitude and RSFC changed with treatment indicate distinct mitochondrion-mediated spontaneous neuronal activity coupling within the various RSFC networks determined by resting state fMRI. Copyright © 2015 John Wiley & Sons, Ltd.

Use of caries-preventive agents in children: findings from the dental practice-based research network.

PubMed

Riley, J L; Richman, Joshua S; Rindal, D Brad; Fellows, Jeffrey L; Qvist, Vibeke; Gilbert, Gregg H; Gordan, Valeria V

2010-01-01

Scientific evidence supports the application of caries-preventive agents in children and adolescents, and this knowledge must be applied to the practice of dentistry. There are few multi-region data that allow for comparisons of practice patterns between types of dental practices and geographical regions. The objective of the present study was to characterise the use of specific caries-preventive agents for paediatric patients in a large multi-region sample of practising clinicians. The present study surveyed clinicians from the Dental Practice-based Research Network who perform restorative dentistry in their practices. The survey consisted of a questionnaire that presented a range of questions about caries risk assessment and the use of preventive techniques in children aged 6 to 18 years. Dental sealants (69%) or in-office fluoride (82%) were the most commonly used caries-preventive agents of the caries preventive regimens. The recommendation of at-home caries-preventive agents ranged from 36% to 7%,with the most commonly used agent being non-prescription fluoride rinse. Clinicians who practised in a large group practice model and clinicians who come from the Scandinavian region use caries risk assessment more frequently compared to clinicians who come from regions that had, predominantly, clinicians in private practice. Whether or not clinicians used caries risk assessment with their paediatric patients was poorly correlated with the likelihood of actually using caries-preventive treatments on patients. Although clinicians reported the use of some form of in-office caries-preventive agent, there was considerable variability across practices. These differences could represent a lack of consensus across practising clinicians about the benefits of caries-preventive agents, or a function of differing financial incentives, or patient pools with differing levels of overall caries risk.

Optimal layout design of obstacles for panic evacuation using differential evolution

NASA Astrophysics Data System (ADS)

Zhao, Yongxiang; Li, Meifang; Lu, Xin; Tian, Lijun; Yu, Zhiyong; Huang, Kai; Wang, Yana; Li, Ting

2017-01-01

To improve the pedestrian outflow in panic situations by suitably placing an obstacle in front of the exit, it is vital to understand the physical mechanism behind the evacuation efficiency enhancement. In this paper, a robust differential evolution is firstly employed to optimize the geometrical parameters of different shaped obstacles in order to achieve an optimal evacuation efficiency. Moreover, it is found that all the geometrical parameters of obstacles could markedly influence the evacuation efficiency of pedestrians, and the best way for achieving an optimal pedestrian outflow is to slightly shift the obstacle from the center of the exit which is consistent with findings of extant literature. Most importantly, by analyzing the profiles of density, velocity and specific flow, as well as the spatial distribution of crowd pressure, we have proven that placing an obstacle in panic situations does not reduce or absorb the pressure in the region of exit, on the contrary, promotes the pressure to a much higher level, hence the physical mechanism behind the evacuation efficiency enhancement is not a pressure decrease in the region of exit, but a significant reduction of high density region by effective separation in space which finally causes the increasing of escape speed and evacuation outflow. Finally, it is clearly demonstrated that the panel-like obstacle is considerably more robust and stable than the pillar-like obstacle to guarantee the enhancement of evacuation efficiency under different initial pedestrian distributions, different initial crowd densities as well as different desired velocities.

Landscape configuration is the primary driver of impacts on water quality associated with agricultural expansion

NASA Astrophysics Data System (ADS)

Chaplin-Kramer, Rebecca; Hamel, Perrine; Sharp, Richard; Kowal, Virgina; Wolny, Stacie; Sim, Sarah; Mueller, Carina

2016-07-01

Corporations and other multinational institutions are increasingly looking to evaluate their innovation and procurement decisions over a range of environmental criteria, including impacts on ecosystem services according to the spatial configuration of activities on the landscape. We have developed a spatially explicit approach and modeled a hypothetical corporate supply chain decision representing contrasting patterns of land-use change in four regions of the globe. This illustrates the effect of introducing spatial considerations in the analysis of ecosystem services, specifically sediment retention. We explored a wide variety of contexts (Iowa, USA; Mato Grosso, Brazil; and Jiangxi and Heilongjiang in China) and these show that per-area representation of impacts based on the physical characterization of a region can be misleading. We found two- to five-fold differences in sediment export for the same amount of habitat conversion within regions characterized by similar physical traits. These differences were mainly determined by the distance between land use changes and streams. The influence of landscape configuration is so dramatic that it can override wide variation in erosion potential driven by physical factors like soil type, slope, and climate. To minimize damage to spatially-dependent ecosystem services like water purification, sustainable sourcing strategies should not assume a direct correlation between impact and area but rather allow for possible nonlinearity in impacts, especially in regions with little remaining habitat and highly variable hydrological connectivity.

Allergen manufacturing and quality aspects for allergen immunotherapy in Europe and the United States: An analysis from the EAACI AIT Guidelines Project.

PubMed

Bonertz, A; Roberts, G; Slater, J E; Bridgewater, J; Rabin, R L; Hoefnagel, M; Timon, M; Pini, C; Pfaar, O; Sheikh, A; Ryan, D; Akdis, C; Goldstein, J; Poulsen, L K; van Ree, R; Rhyner, C; Barber, D; Palomares, O; Pawankar, R; Hamerlijnk, D; Klimek, L; Agache, I; Angier, E; Casale, T; Fernandez-Rivas, M; Halken, S; Jutel, M; Lau, S; Pajno, G; Sturm, G; Varga, E M; Gerth van Wijk, R; Bonini, S; Muraro, A; Vieths, S

2018-04-01

Adequate quality is essential for any medicinal product to be eligible for marketing. Quality includes verification of the identity, content and purity of a medicinal product in combination with a specified production process and its control. Allergen products derived from natural sources require particular considerations to ensure adequate quality. Here, we describe key aspects of the documentation on manufacturing and quality aspects for allergen immunotherapy products in the European Union and the United States. In some key parts, requirements in these areas are harmonized while other fields are regulated separately between both regions. Essential differences are found in the use of Reference Preparations, or the requirement to apply standardized assays for potency determination. As the types of products available are different in specific regions, regulatory guidance for such products may also be available in one specific region only, such as for allergoids in the European Union. Region-specific issues and priorities are a result of this. As allergen products derived from natural sources are inherently variable in their qualitative and quantitative composition, these products present special challenges to balance the variability and ensuring batch-to-batch consistency. Advancements in scientific knowledge on specific allergens and their role in allergic disease will consequentially find representation in future regulatory guidelines. © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

Dipole sources of the human alpha rhythm.

PubMed

Rodin, E A; Rodin, M J

1995-01-01

Dipole sources were investigated in 22 normal subjects with a variety of strategies available through the BESA program. When all the data were summed one regional source, located near the midline in the basal portions of the occipital lobe, explained 92% of the variance. Two regional sources, initially constrained for symmetry but subsequently freed from constraint placed them also in the occipital regions near the midline and reduced the residual variance to 4%. Pooled data obscure, however, the marked individual differences especially in regard to lateralization. In the individual case the major source was also always in one occipital area but its location, especially the degree of separation from the midline depended upon alpha distribution and the strategy used in the workup of the data. The orientation of the major components of the regional sources was usually in the posterior-anterior direction, fairly parallel to the midline and while the other one pointed to the upper convexity. Because of the considerable variability of the alpha rhythm in given subjects and even within the same individual a model which requires symmetry constraints is not optimal for all instances, even when constraints are lifted thereafter. The study demonstrated the feasibility of distinguishing predominantly mesial sources from those which are bihemipheric with more lateral origins but several different models may have to be used to reach the most realistic conclusions.

[Comparative evaluation of six different body regions of the dog using analog and digital radiography].

PubMed

Meyer-Lindenberg, Andrea; Ebermaier, Christine; Wolvekamp, Pim; Tellhelm, Bernd; Meutstege, Freek J; Lang, Johann; Hartung, Klaus; Fehr, Michael; Nolte, Ingo

2008-01-01

In this study the quality of digital and analog radiography in dogs was compared. For this purpose, three conventional radiographs (varying in exposure) and three digital radiographs (varying in MUSI-contrast [MUSI = MUlti Scale Image Contrast], the main post-processing parameter) of six different body regions of the dog were evaluated (thorax, abdomen, skull, femur, hip joints, elbow). The quality of the radiographs was evaluated by eight veterinary specialists familiar with radiographic images using a questionnaire based on details of each body region significant in obtaining a radiographic diagnosis. In the first part of the study the overall quality of the radiographs was evaluated. Within one region, 89.5% (43/48) chose a digital radiograph as the best image. Divided into analog and digital groups, the digital image with the highest MUSI-contrast was most often considered the best, while the analog image considered the best varied between the one with the medium and the one with the longest exposure time. In the second part of the study, each image was rated for the visibility of specific, diagnostically important details. After summarisation of the scores for each criterion, divided into analog and digital imaging, the digital images were rated considerably superior to conventional images. The results of image comparison revealed that digital radiographs showed better image detail than radiographs taken with the analog technique in all six areas of the body.

43 CFR 3420.2 - Regional leasing levels.

Code of Federal Regulations, 2013 CFR

2013-10-01

... have properly considered social, environmental and economic impacts and constraints. (a) The regional.... This review shall be designed to ensure consideration of relevant social, environmental and economic... recommendations are in an appropriate format; (ii) add any additional information from the Bureau of Land...

43 CFR 3420.2 - Regional leasing levels.

Code of Federal Regulations, 2012 CFR

2012-10-01

... have properly considered social, environmental and economic impacts and constraints. (a) The regional.... This review shall be designed to ensure consideration of relevant social, environmental and economic... recommendations are in an appropriate format; (ii) add any additional information from the Bureau of Land...

43 CFR 3420.2 - Regional leasing levels.

Code of Federal Regulations, 2014 CFR

2014-10-01

... have properly considered social, environmental and economic impacts and constraints. (a) The regional.... This review shall be designed to ensure consideration of relevant social, environmental and economic... recommendations are in an appropriate format; (ii) add any additional information from the Bureau of Land...

Novel methods for parameter-based analysis of myocardial tissue in MR images

NASA Astrophysics Data System (ADS)

Hennemuth, A.; Behrens, S.; Kuehnel, C.; Oeltze, S.; Konrad, O.; Peitgen, H.-O.

2007-03-01

The analysis of myocardial tissue with contrast-enhanced MR yields multiple parameters, which can be used to classify the examined tissue. Perfusion images are often distorted by motion, while late enhancement images are acquired with a different size and resolution. Therefore, it is common to reduce the analysis to a visual inspection, or to the examination of parameters related to the 17-segment-model proposed by the American Heart Association (AHA). As this simplification comes along with a considerable loss of information, our purpose is to provide methods for a more accurate analysis regarding topological and functional tissue features. In order to achieve this, we implemented registration methods for the motion correction of the perfusion sequence and the matching of the late enhancement information onto the perfusion image and vice versa. For the motion corrected perfusion sequence, vector images containing the voxel enhancement curves' semi-quantitative parameters are derived. The resulting vector images are combined with the late enhancement information and form the basis for the tissue examination. For the exploration of data we propose different modes: the inspection of the enhancement curves and parameter distribution in areas automatically segmented using the late enhancement information, the inspection of regions segmented in parameter space by user defined threshold intervals and the topological comparison of regions segmented with different settings. Results showed a more accurate detection of distorted regions in comparison to the AHA-model-based evaluation.

Stream fish colonization but not persistence varies regionally across a large North American river basin

USGS Publications Warehouse

Wheeler, Kit; Wengerd, Seth J.; Walsh, Stephen J.; Martin, Zachary P.; Jelks, Howard L.; Freeman, Mary C.

2018-01-01

Many species have distributions that span distinctly different physiographic regions, and effective conservation of such taxa will require a full accounting of all factors that potentially influence populations. Ecologists recognize effects of physiographic differences in topography, geology and climate on local habitat configurations, and thus the relevance of landscape heterogeneity to species distributions and abundances. However, research is lacking that examines how physiography affects the processes underlying metapopulation dynamics. We used data describing occupancy dynamics of stream fishes to evaluate evidence that physiography influences rates at which individual taxa persist in or colonize stream reaches under different flow conditions. Using periodic survey data from a stream fish assemblage in a large river basin that encompasses multiple physiographic regions, we fit multi-species dynamic occupancy models. Our modeling results suggested that stream fish colonization but not persistence was strongly governed by physiography, with estimated colonization rates considerably higher in Coastal Plain streams than in Piedmont and Blue Ridge systems. Like colonization, persistence was positively related to an index of stream flow magnitude, but the relationship between flow and persistence did not depend on physiography. Understanding the relative importance of colonization and persistence, and how one or both processes may change across the landscape, is critical information for the conservation of broadly distributed taxa, and conservation strategies explicitly accounting for spatial variation in these processes are likely to be more successful for such taxa.

Acceleration of low-energy protons and alpha particles at interplanetary shock waves

NASA Technical Reports Server (NTRS)

Scholer, M.; Hovestadt, D.; Ipavich, F. M.; Gloeckler, G.

1983-01-01

The low-energy protons and alpha particles in the energy range 30 keV/charge to 150 keV/charge associated with three different interplanetary shock waves in the immediate preshock and postshock region are studied using data obtained by the ISEE 3. The spatial distributions in the preshock and postshock medium are presented, and the dependence of the phase space density at different energies on the distance from the shock and on the form of the distribution function of both species immediately at the shock is examined. It is found that in the preshock region the particles are flowing in the solar wind frame of reference away from the shock and in the postshock medium the distribution is more or less isotropic in this frame of reference. The distribution function in the postshock region can be represented by a power law in energy which has the same spectral exponent for both protons and alpha particles. It is concluded that the first-order Fermi acceleration process can consistently explain the data, although the spectra of diffuse bow shock associated particles are different from the spectra of the interplanetary shock-associated particles in the immediate vicinity of the shock. In addition, the mean free path of the low energy ions in the preshock medium is found to be considerably smaller than the mean free path determined by the turbulence of the background interplanetary medium.

The Influence of Head Motion on Intrinsic Functional Connectivity MRI

PubMed Central

Van Dijk, Koene R.A.; Sabuncu, Mert R.; Buckner, Randy L.

2011-01-01

Functional connectivity MRI (fcMRI) has been widely applied to explore group and individual differences. A confounding factor is head motion. Children move more than adults, older adults more than younger adults, and patients more than controls. Head motion varies considerably among individuals within the same population. Here we explored the influence of head motion on fcMRI estimates. Mean head displacement, maximum head displacement, the number of micro movements (> 0.1 mm), and head rotation were estimated in 1000 healthy, young adult subjects each scanned for two resting-state runs on matched 3T scanners. The majority of fcMRI variation across subjects was not linked to estimated head motion. However, head motion had significant, systematic effects on fcMRI network measures. Head motion was associated with decreased functional coupling in the default and frontoparietal control networks – two networks characterized by coupling among distributed regions of association cortex. Other network measures increased with motion including estimates of local functional coupling and coupling between left and right motor regions – a region pair sometimes used as a control in studies to establish specificity. Comparisons between groups of individuals with subtly different levels of head motion yielded difference maps that could be mistaken for neuronal effects in other contexts. These effects are important to consider when interpreting variation between groups and across individuals. PMID:21810475

Bumble Bee Fauna of Palouse Prairie: Survey of Native Bee Pollinators in a Fragmented Ecosystem

PubMed Central

Hatten, T. D.; Looney, C.; Strange, J. P.; Bosque-Pérez, N. A.

2013-01-01

Bumble bees, Bombus Latreille (Hymenoptera: Apidae:), are dominant pollinators in the northern hemisphere, providing important pollination services for commercial crops and innumerable wild plants. Nationwide declines in several bumble bee species and habitat losses in multiple ecosystems have raised concerns about conservation of this important group. In many regions, such as the Palouse Prairie, relatively little is known about bumble bee communities, despite their critical ecosystem functions. Pitfall trap surveys for ground beetles in Palouse prairie remnants conducted in 2002–2003 contained considerable by-catch of bumble bees. The effects of landscape context, remnant features, year, and season on bumble bee community composition were examined. Additionally, bees captured in 2002–2003 were compared with historic records for the region to assess changes in the presence of individual species. Ten species of bumble bee were captured, representing the majority of the species historically known from the region. Few detectable differences in bumble bee abundances were found among remnants. Community composition differed appreciably, however, based on season, landscape context, and elevation, resulting in different bee assemblages between western, low-lying remnants and eastern, higherelevation remnants. The results suggest that conservation of the still species-rich bumble bee fauna should take into account variability among prairie remnants, and further work is required to adequately explain bumble bee habitat associations on the Palouse. PMID:23902138

Heterogeneity of anatomic regions by MR volumetry in juvenile myoclonic epilepsy.

PubMed

Swartz, B E; Spitz, J; Vu, A L; Mandelkern, M; Su, M L

2016-10-01

To investigate brain volumes in patients with well-characterized juvenile myoclonic epilepsy (JME). We studied the MRI images of seventeen subjects with EEG and clinically defined JME and seventeen age- and sex-matched controls using voxel-based morphometry (VBM) and automated and manual volumetry. We found no significant group differences in the cortical volumes by automated techniques for all regions or for the whole brain. However, we found a larger pulvinar nucleus in JME using VBM with small volume correction and a larger thalamus with manual volumetry (P = 0.001; corrected two-tailed t-test). By analysing the individual subjects, we determined that considerable heterogeneity exists even in this highly selected group. Histograms of all JME and matched control regions' volumes showed more subjects with JME had smaller hippocampi and larger thalami (P < 0.05; chi-square). Subjects in whom the first seizure was absence were more likely to have smaller hippocampi than their matched control, while those without absences showed no differences (P < 0.05, chi-square). There is ample evidence for frontal cortical thalamic network changes in JME, but subcortical structural differences were more distinct in this group. Given the heterogeneity of brain volumes in the clinical population, further advancement in the field will require the examination of stringent genetically controlled populations. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Estimation of design space for an extrusion-spheronization process using response surface methodology and artificial neural network modelling.

PubMed

Sovány, Tamás; Tislér, Zsófia; Kristó, Katalin; Kelemen, András; Regdon, Géza

2016-09-01

The application of the Quality by Design principles is one of the key issues of the recent pharmaceutical developments. In the past decade a lot of knowledge was collected about the practical realization of the concept, but there are still a lot of unanswered questions. The key requirement of the concept is the mathematical description of the effect of the critical factors and their interactions on the critical quality attributes (CQAs) of the product. The process design space (PDS) is usually determined by the use of design of experiment (DoE) based response surface methodologies (RSM), but inaccuracies in the applied polynomial models often resulted in the over/underestimation of the real trends and changes making the calculations uncertain, especially in the edge regions of the PDS. The completion of RSM with artificial neural network (ANN) based models is therefore a commonly used method to reduce the uncertainties. Nevertheless, since the different researches are focusing on the use of a given DoE, there is lack of comparative studies on different experimental layouts. Therefore, the aim of present study was to investigate the effect of the different DoE layouts (2 level full factorial, Central Composite, Box-Behnken, 3 level fractional and 3 level full factorial design) on the model predictability and to compare model sensitivities according to the organization of the experimental data set. It was revealed that the size of the design space could differ more than 40% calculated with different polynomial models, which was associated with a considerable shift in its position when higher level layouts were applied. The shift was more considerable when the calculation was based on RSM. The model predictability was also better with ANN based models. Nevertheless, both modelling methods exhibit considerable sensitivity to the organization of the experimental data set, and the use of design layouts is recommended, where the extreme values factors are more represented. Copyright © 2016 Elsevier B.V. All rights reserved.

How to choose methods for lake greenhouse gas flux measurements?

NASA Astrophysics Data System (ADS)

Bastviken, David

2017-04-01

Lake greenhouse gas (GHG) fluxes are increasingly recognized as important for lake ecosystems as well as for large scale carbon and GHG budgets. However, many of our flux estimates are uncertain and it can be discussed if the presently available data is representative for the systems studied or not. Data are also very limited for some important flux pathways. Hence, many ongoing efforts try to better constrain fluxes and understand flux regulation. A fundamental challenge towards improved knowledge and when starting new studies is what methods to choose. A variety of approaches to measure aquatic GHG exchange is used and data from different methods and methodological approaches have often been treated as equally valid to create large datasets for extrapolations and syntheses. However, data from different approaches may cover different flux pathways or spatio-temporal domains and are thus not always comparable. Method inter-comparisons and critical method evaluations addressing these issues are rare. Emerging efforts to organize systematic multi-lake monitoring networks for GHG fluxes leads to method choices that may set the foundation for decades of data generation and therefore require fundamental evaluation of different approaches. The method choices do not only regard the equipment but also for example consideration of overall measurement design and field approaches, relevant spatial and temporal resolution for different flux components, and accessory variables to measure. In addition, consideration of how to design monitoring approaches being affordable, suitable for widespread (global) use, and comparable across regions is needed. Inspired by discussions with Prof. Dr. Cristian Blodau during the EGU General Assembly 2016, this presentation aims to (1) illustrate fundamental pros and cons for a number of common methods, (2) show how common methodological approaches originally adapted for other environments can be improved for lake flux measurements, (3) suggest how consideration of spatio-temporal dimensions of flux variability can lead to more optimized approaches, and (4) highlight possibilities of efficient ways forward including low-cost technologies that has potential for world-wide use.

Influence of climate on landscape characteristics in safety assessments of repositories for radioactive wastes.

PubMed

Becker, J K; Lindborg, T; Thorne, M C

2014-12-01

In safety assessments of repositories for radioactive wastes, large spatial and temporal scales have to be considered when developing an approach to risk calculations. A wide range of different types of information may be required. Local to the site of interest, temperature and precipitation data may be used to determine the erosional regime (which may also be conditioned by the vegetation characteristics adopted, based both on climatic and other considerations). However, geomorphological changes may be governed by regional rather than local considerations, e.g. alteration of river base levels, river capture and drainage network reorganisation, or the progression of an ice sheet or valley glacier across the site. The regional climate is in turn governed by the global climate. In this work, a commentary is presented on the types of climate models that can be used to develop projections of climate change for use in post-closure radiological impact assessments of geological repositories for radioactive wastes. These models include both Atmosphere-Ocean General Circulation Models and Earth Models of Intermediate Complexity. The relevant outputs available from these models are identified and consideration is given to how these outputs may be used to inform projections of landscape development. Issues of spatial and temporal downscaling of climate model outputs to meet the requirements of local-scale landscape development modelling are also addressed. An example is given of how climate change and landscape development influence the radiological impact of radionuclides potentially released from the deep geological disposal facility for spent nuclear fuel that SKB (the Swedish Nuclear Fuel and Waste Management Company) proposes to construct at Forsmark, Sweden. Copyright © 2014 Elsevier Ltd. All rights reserved.

A near infrared line list for NH3: Analysis of a Kitt Peak spectrum after 35 years

NASA Astrophysics Data System (ADS)

Barton, Emma J.; Yurchenko, Sergei N.; Tennyson, Jonathan; Béguier, Serge; Campargue, Alain

2016-07-01

A Fourier Transform (FT) absorption spectrum of room temperature NH3 in the region 7400-8640 cm-1 is analysed using a variational line list and ground state energies determined using the MARVEL procedure. The spectrum was measured by Dr. Catherine de Bergh in 1980 and is available from the Kitt Peak data center. The centers and intensities of 8468 ammonia lines were retrieved using a multiline fitting procedure. 2474 lines are assigned to 21 bands providing 1692 experimental energies in the range 7500-9200 cm-1. The spectrum was assigned by the joint use of the BYTe variational line list and combination differences. The assignments and experimental energies presented in this work are the first for ammonia in the region 7400-8640 cm-1, considerably extending the range of known vibrational-excited states.

Disaster incubation, cumulative impacts and the urban/ex-urban/rural dynamic

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mulvihill, Peter R.; Ali, S. Harris

2007-05-15

This article explores environmental impacts and risks that can accumulate in rural and ex-urban areas and regions and their relation to urban and global development forces. Two Southern Ontario cases are examined: an area level water disaster and cumulative change at the regional level. The role of disaster incubation analysis and advanced environmental assessment tools are discussed in terms of their potential to contribute to more enlightened and effective assessment and planning processes. It is concluded that conventional approaches to EA and planning are characteristically deficient in addressing the full range of impacts and risks, and particularly those originating frommore » pathogens, dispersed and insidious sources. Rigorous application of disaster incubation analysis and more advanced forms of EA has considerable potential to influence a different pattern of planning and decision making.« less

RPS8—a New Informative DNA Marker for Phylogeny of Babesia and Theileria Parasites in China

PubMed Central

Tian, Zhan-Cheng; Liu, Guang-Yuan; Yin, Hong; Luo, Jian-Xun; Guan, Gui-Quan; Luo, Jin; Xie, Jun-Ren; Shen, Hui; Tian, Mei-Yuan; Zheng, Jin-feng; Yuan, Xiao-song; Wang, Fang-fang

2013-01-01

Piroplasmosis is a serious debilitating and sometimes fatal disease. Phylogenetic relationships within piroplasmida are complex and remain unclear. We compared the intron–exon structure and DNA sequences of the RPS8 gene from Babesia and Theileria spp. isolates in China. Similar to 18S rDNA, the 40S ribosomal protein S8 gene, RPS8, including both coding and non-coding regions is a useful and novel genetic marker for defining species boundaries and for inferring phylogenies because it tends to have little intra-specific variation but considerable inter-specific difference. However, more samples are needed to verify the usefulness of the RPS8 (coding and non-coding regions) gene as a marker for the phylogenetic position and detection of most Babesia and Theileria species, particularly for some closely related species. PMID:24244571

Tissue adhesives in otorhinolaryngology

PubMed Central

Schneider, Gerlind

2011-01-01

The development of medical tissue adhesives has a long history without finding an all-purpose tissue adhesive for clinical daily routine. This is caused by the specific demands which are made on a tissue adhesive, and the different areas of application. In otorhinolaryngology, on the one hand, this is the mucosal environment as well as the application on bones, cartilage and periphery nerves. On the other hand, there are stressed regions (skin, oral cavity, pharynx, oesophagus, trachea) and unstressed regions (middle ear, nose and paranasal sinuses, cranial bones). But due to the facts that adhesives can have considerable advantages in assuring surgery results, prevention of complications and so reduction of medical costs/treatment expenses, the search for new adhesives for use in otorhinolaryngology will be continued intensively. In parallel, appropriate application systems have to be developed for microscopic and endoscopic use. PMID:22073094

Assessing Seasonal and Inter-Annual Variations of Lake Surface Areas in Mongolia during 2000-2011 Using Minimum Composite MODIS NDVI

PubMed Central

Kang, Sinkyu; Hong, Suk Young

2016-01-01

A minimum composite method was applied to produce a 15-day interval normalized difference vegetation index (NDVI) dataset from Moderate Resolution Imaging Spectroradiometer (MODIS) daily 250 m reflectance in the red and near-infrared bands. This dataset was applied to determine lake surface areas in Mongolia. A total of 73 lakes greater than 6.25 km2in area were selected, and 28 of these lakes were used to evaluate detection errors. The minimum composite NDVI showed a better detection performance on lake water pixels than did the official MODIS 16-day 250 m NDVI based on a maximum composite method. The overall lake area detection performance based on the 15-day minimum composite NDVI showed -2.5% error relative to the Landsat-derived lake area for the 28 evaluated lakes. The errors increased with increases in the perimeter-to-area ratio but decreased with lake size over 10 km2. The lake area decreased by -9.3% at an annual rate of -53.7 km2 yr-1 during 2000 to 2011 for the 73 lakes. However, considerable spatial variations, such as slight-to-moderate lake area reductions in semi-arid regions and rapid lake area reductions in arid regions, were also detected. This study demonstrated applicability of MODIS 250 m reflectance data for biweekly monitoring of lake area change and diagnosed considerable lake area reduction and its spatial variability in arid and semi-arid regions of Mongolia. Future studies are required for explaining reasons of lake area changes and their spatial variability. PMID:27007233

Assessing Seasonal and Inter-Annual Variations of Lake Surface Areas in Mongolia during 2000-2011 Using Minimum Composite MODIS NDVI.

PubMed

Kang, Sinkyu; Hong, Suk Young

2016-01-01

A minimum composite method was applied to produce a 15-day interval normalized difference vegetation index (NDVI) dataset from Moderate Resolution Imaging Spectroradiometer (MODIS) daily 250 m reflectance in the red and near-infrared bands. This dataset was applied to determine lake surface areas in Mongolia. A total of 73 lakes greater than 6.25 km2in area were selected, and 28 of these lakes were used to evaluate detection errors. The minimum composite NDVI showed a better detection performance on lake water pixels than did the official MODIS 16-day 250 m NDVI based on a maximum composite method. The overall lake area detection performance based on the 15-day minimum composite NDVI showed -2.5% error relative to the Landsat-derived lake area for the 28 evaluated lakes. The errors increased with increases in the perimeter-to-area ratio but decreased with lake size over 10 km(2). The lake area decreased by -9.3% at an annual rate of -53.7 km(2) yr(-1) during 2000 to 2011 for the 73 lakes. However, considerable spatial variations, such as slight-to-moderate lake area reductions in semi-arid regions and rapid lake area reductions in arid regions, were also detected. This study demonstrated applicability of MODIS 250 m reflectance data for biweekly monitoring of lake area change and diagnosed considerable lake area reduction and its spatial variability in arid and semi-arid regions of Mongolia. Future studies are required for explaining reasons of lake area changes and their spatial variability.

A spatiotemporal multi-hazard exposure assessment based on property data

NASA Astrophysics Data System (ADS)

Fuchs, S.; Keiler, M.; Zischg, A.

2015-09-01

The paper presents a nation-wide spatially explicit object-based assessment of buildings and citizens exposed to natural hazards in Austria, including river flooding, torrential flooding, and snow avalanches. The assessment was based on two different data sets, (a) hazard information providing input to the exposure of elements at risk, and (b) information on the building stock combined from different spatial data available on the national level. Hazard information was compiled from two different sources. For torrential flooding and snow avalanches available local-scale hazard maps were used, and for river flooding the results of the countrywide flood modelling eHORA were available. Information on the building stock contained information on the location and size of each building, as well as on the building category and the construction period. Additional information related to the individual floors, such as their height and net area, main purpose and configuration, was included for each property. Moreover, this data set has an interface to the population register and allowed, therefore, for retrieving the number of primary residents for each building. With the exception of sacral buildings, an economic module was used to compute the monetary value of buildings using (a) the information of the building register such as building type, number of storeys and utilisation, and (b) regionally averaged construction costs. It is shown that the repeatedly stated assumption of increasing exposure due to continued population growth and related increase in assets has to be carefully evaluated by the local development of building stock. While some regions have shown a clearly above-average increase in assets, other regions were characterised by a below-average development. This mirrors the topography of the country, but also the different economic activities. While hotels and hostels are extraordinarily prone to torrential flooding, commercial buildings as well as buildings used for recreational purposes are considerably exposed to river flooding. Residential buildings have shown an average exposure, compared to the number of buildings of this type in the overall building stock. In sum, around 5 % of all buildings are exposed to torrential flooding, and around 9 % to river flooding, with around 1 % of the buildings stock being multi-exposed. The temporal assessment of exposure has shown considerable differences in the dynamics of exposure to different hazard categories in comparison to the overall property stock. In conclusion, the presented object-based assessment is an important and suitable tool for nation-wide exposure assessment and may be used in operational risk management.

Effects of climate, vegetation, and soils on consumptive water use and ground-water recharge to the Central Midwest Regional aquifer system, Mid-continent United States

USGS Publications Warehouse

Dugan, J.T.; Peckenpaugh, J.M.

1985-01-01

The Central Midwest aquifer system, in parts of Arkansas, Colorado, Kansas, Missouri, Nebraska, New Mexico, South Dakota, and Texas, is a region of great hydrologic diversity. This study examines the relationships between climate, vegetation, and soil that affect consumptive water use and recharge to the groundwater system. Computations of potential recharge and consumptive water use were restricted to those areas where the aquifers under consideration were the immediate underlying system. The principal method of analysis utilized a soil moisture computer model. This model requires four types of input: (1) hydrologic properties of the soils, (2) vegetation types, (3) monthly precipitation, and (4) computed monthly potential evapotranspiration (PET) values. The climatic factors that affect consumptive water use and recharge were extensively mapped for the study area. Nearly all the pertinent climatic elements confirmed the extreme diversity of the region. PET and those factors affecting it--solar radiation, temperature, and humidity--showed large regional differences; mean annual PET ranged from 36 to 70 inches in the study area. The seasonal climatic patterns indicate significant regional differences in those factors affecting seasonal consumptive water use and recharge. In the southern and western parts of the study area, consumptive water use occurred nearly the entire year; whereas, in northern parts it occurred primarily during the warm season (April through September). Results of the soil-moisture program, which added the effects of vegetation and the hydrologic characteristics of the soil to computed PET values, confirmed the significant regional differences in consumptive water use or actual evapotranspiration (AET) and potential groundwater recharge. Under two different vegetative conditions--the 1978 conditions and pre-agricultural conditions consisting of only grassland and woodland--overall differences in recharge were minimal. Mean annual recharge under both conditions averaged slightly more than 4.5 inches for the entire study area, but ranged from less than 0.10 inches in eastern Colorado to slightly more than 15 inches in Arkansas. (Lantz-PTT)

Reliability Considerations for Ultra- Low Power Space Applications

NASA Technical Reports Server (NTRS)

White, Mark; Johnston, Allan

2012-01-01

NASA, the aerospace community, and other high reliability (hi-rel) users of advanced microelectronic products face many challenges as technology continues to scale into the deep sub- micron region and ULP devices are sought after. Technology trends, ULP microelectronics, scaling and performance tradeoffs, reliability considerations, and spacecraft environments will be presented from a ULP perspective for space applications.

Achromatization In The 3 To 5 μm Spectral Region With Visible Light Transmitting Materials

NASA Astrophysics Data System (ADS)

McDowell, M. W.; Klee, H. W.

1984-04-01

The theoretical performances of several f/1.5 triplet lenses suitable for use in the 3 to 5um spectral region are compared. Examples are given in which all the materials used have a finite visible transmittance. As centering errors can thus be considerably reduced, it is expected that such a lens will in practice approach more closely its theoretical performance. These lenses are also considerably less sensitive to manufacturing tolerances as a result of lower index materials, and the use of low dn/dT materials offers other advantages over the more usual silicon-germanium combination.

Contribution of estradiol levels and hormonal contraceptives to sex differences within the fear network during fear conditioning and extinction.

PubMed

Hwang, Moon Jung; Zsido, Rachel G; Song, Huijin; Pace-Schott, Edward F; Miller, Karen Klahr; Lebron-Milad, Kelimer; Marin, Marie-France; Milad, Mohammed R

2015-11-18

Findings about sex differences in the field of fear conditioning and fear extinction have been mixed. At the psychophysiological level, sex differences emerge only when taking estradiol levels of women into consideration. This suggests that this hormone may also influence sex differences with regards to activations of brain regions involved in fear conditioning and its extinction. Importantly, the neurobiological correlates associated with the use of hormonal oral contraceptives in women have not been fully contrasted against men and against naturally cycling women with different levels of estradiol. In this study, we begin to fill these scientific gaps. We recruited 37 healthy men and 48 healthy women. Of these women, 16 were using oral contraceptives (OC) and 32 were naturally cycling. For these naturally cycling women, a median split was performed on their serum estradiol levels to create a high estradiol (HE) group (n = 16) and a low estradiol (LE) group (n = 16). All participants underwent a 2-day fear conditioning and extinction paradigm in a 3 T MR scanner. Using the 4 groups (men, HE women, LE women, and OC users) and controlling for age and coil type, one-way ANCOVAs were performed to look at significant activations within the nodes of the fear circuit. Using post-hoc analyses, beta-weights were extracted in brain regions showing significant effects in order to unveil the differences based on hormonal status (men, HE, LE, OC). Significant main effect of hormonal status group was found across the different phases of the experiment and in different sub-regions of the insular and cingulate cortices, amygdala, hippocampus, and hypothalamus. During conditioning, extinction and recall, most of the observed differences suggested higher activations among HE women relative to men. During the unconditioned response, however, a different pattern was observed with men showing significantly higher brain activations. Our data further support the important contribution of estradiol levels in the activation of brain regions underlying fear learning and extinction. The results highlight the need to document gonadal hormonal levels, menstrual cycle phase as well as oral contraceptive use in women in order to avoid overlooking sex differences when investigating the neurobiology of emotional regulation.

Hydrological responses to climatic changes in the Yellow River basin, China: Climatic elasticity and streamflow prediction

NASA Astrophysics Data System (ADS)

Zhang, Qiang; Liu, Jianyu; Singh, Vijay P.; Shi, Peijun; Sun, Peng

2017-11-01

Prediction of streamflow of the Yellow River basin was done using downscaled precipitation and temperature based on outputs of 12 GCMs under RCP2.6 and RCP8.5 scenarios. Streamflow changes of 37 tributaries of the Yellow River basin during 2070-2099 were predicted related to different GCMs and climatic scenarios using Budyko framework. The results indicated that: (1) When compared to precipitation and temperature during 1960-1979, increasing precipitation and temperature are dominant during 2070-2099. Particularly, under RCP8.5, increase of 10% and 30% can be detected for precipitation and temperature respectively; (2) Precipitation changes have larger fractional contribution to streamflow changes than temperature changes, being the major driver for spatial and temporal patterns of water resources across the Yellow River basin; (3) 2070-2099 period will witness increased streamflow depth and decreased streamflow can be found mainly in the semi-humid regions and headwater regions of the Yellow River basin, which can be attributed to more significant increase of temperature than precipitation in these regions; (4) Distinctly different picture of streamflow changes can be observed with consideration of different outputs of GCMs which can be attributed to different outputs of GCMs under different scenarios. Even so, under RCP2.6 and RCP8.5 scenarios, 36.8% and 71.1% of the tributaries of the Yellow River basin are dominated by increasing streamflow. The results of this study are of theoretical and practical merits in terms of management of water resources and also irrigated agriculture under influences of changing climate.

Implementation of equity in resource allocation for regional earthquake risk mitigation using two-stage stochastic programming.

PubMed

Zolfaghari, Mohammad R; Peyghaleh, Elnaz

2015-03-01

This article presents a new methodology to implement the concept of equity in regional earthquake risk mitigation programs using an optimization framework. It presents a framework that could be used by decisionmakers (government and authorities) to structure budget allocation strategy toward different seismic risk mitigation measures, i.e., structural retrofitting for different building structural types in different locations and planning horizons. A two-stage stochastic model is developed here to seek optimal mitigation measures based on minimizing mitigation expenditures, reconstruction expenditures, and especially large losses in highly seismically active countries. To consider fairness in the distribution of financial resources among different groups of people, the equity concept is incorporated using constraints in model formulation. These constraints limit inequity to the user-defined level to achieve the equity-efficiency tradeoff in the decision-making process. To present practical application of the proposed model, it is applied to a pilot area in Tehran, the capital city of Iran. Building stocks, structural vulnerability functions, and regional seismic hazard characteristics are incorporated to compile a probabilistic seismic risk model for the pilot area. Results illustrate the variation of mitigation expenditures by location and structural type for buildings. These expenditures are sensitive to the amount of available budget and equity consideration for the constant risk aversion. Most significantly, equity is more easily achieved if the budget is unlimited. Conversely, increasing equity where the budget is limited decreases the efficiency. The risk-return tradeoff, equity-reconstruction expenditures tradeoff, and variation of per-capita expected earthquake loss in different income classes are also presented. © 2015 Society for Risk Analysis.

A dual-phantom system for validation of velocity measurements in stenosis models under steady flow.

PubMed

Blake, James R; Easson, William J; Hoskins, Peter R

2009-09-01

A dual-phantom system is developed for validation of velocity measurements in stenosis models. Pairs of phantoms with identical geometry and flow conditions are manufactured, one for ultrasound and one for particle image velocimetry (PIV). The PIV model is made from silicone rubber, and a new PIV fluid is made that matches the refractive index of 1.41 of silicone. Dynamic scaling was performed to correct for the increased viscosity of the PIV fluid compared with that of the ultrasound blood mimic. The degree of stenosis in the models pairs agreed to less than 1%. The velocities in the laminar flow region up to the peak velocity location agreed to within 15%, and the difference could be explained by errors in ultrasound velocity estimation. At low flow rates and in mild stenoses, good agreement was observed in the distal flow fields, excepting the maximum velocities. At high flow rates, there was considerable difference in velocities in the poststenosis flow field (maximum centreline differences of 30%), which would seem to represent real differences in hydrodynamic behavior between the two models. Sources of error included: variation of viscosity because of temperature (random error, which could account for differences of up to 7%); ultrasound velocity estimation errors (systematic errors); and geometry effects in each model, particularly because of imperfect connectors and corners (systematic errors, potentially affecting the inlet length and flow stability). The current system is best placed to investigate measurement errors in the laminar flow region rather than the poststenosis turbulent flow region.

Market uptake of new antiviral drugs for the treatment of hepatitis C.

PubMed

Lettmeier, Beate; Mühlberger, Nikolai; Schwarzer, Ruth; Sroczynski, Gaby; Wright, Davene; Zeuzem, Stefan; Siebert, Uwe

2008-10-01

Peginterferon plus ribavirin is the state-of-the-art antiviral therapy for prevention of serious complications of hepatitis C. Our aim was to compare market uptake of and access to these drugs across Europe. We collected launch and sales data for peginterferons for 21 countries in the WHO European region and compared country-specific sales rates. Additionally, we converted sales figures into patient numbers and related those to country-specific hepatitis C prevalence, taking into account genotype distribution, patient characteristics and practice patterns. Peginterferon sales rates differed considerably across countries. The earliest, most rapid and highest adoption rates were in EU founder states, followed by EU members that joined after foundation, and EU non-member states. Most new member states showed a marked increase in sales. By the end of 2005, approximately 308,000 patients had been treated with peginterferons in the 21 countries evaluated. The number of patients ever treated ranged from 16% of prevalent cases in France to less than 1% of cases in Romania, Poland, Greece and Russia. Peginterferon market uptake and access differed considerably across Europe, suggesting unequal access to optimised therapy. Besides budget restrictions, national surveillance and treatment policies should be considered as reasons for market access variation.

Charged Particle Diffusion in Isotropic Random Static Magnetic Fields

NASA Astrophysics Data System (ADS)

Subedi, P.; Sonsrettee, W.; Matthaeus, W. H.; Ruffolo, D. J.; Wan, M.; Montgomery, D.

2013-12-01

Study of the transport and diffusion of charged particles in a turbulent magnetic field remains a subject of considerable interest. Research has most frequently concentrated on determining the diffusion coefficient in the presence of a mean magnetic field. Here we consider Diffusion of charged particles in fully three dimensional statistically isotropic magnetic field turbulence with no mean field which is pertinent to many astrophysical situations. We classify different regions of particle energy depending upon the ratio of Larmor radius of the charged particle to the characteristic outer length scale of turbulence. We propose three different theoretical models to calculate the diffusion coefficient each applicable to a distinct range of particle energies. The theoretical results are compared with those from computer simulations, showing very good agreement.

CYP2C19 polymorphism frequency in Russian patients in Central Russia and Siberia with acute coronary syndrome

PubMed Central

Mirzaev, Karin B; Zelenskaya, Elena M; Barbarash, Olga L; Ganyukov, Vladimir I; Apartsin, Konstantin A; Saraeva, Natalya O; Nikolaev, Konstantin Y; Ryzhikova, Kristina A; Lifshits, Galina I; Sychev, Dmitry A

2017-01-01

Purpose The aim of this study is to investigate the frequency of CYP2C19*2, *3 allelic variants, associated with poor response to clopidogrel, and CYP2C19*17, associated with excessive response to clopidogrel, in patients with acute coronary syndrome (ACS) from Siberia and Moscow regions of Russia. Patients and methods The study included 512 ACS patients who were subsequently treated with coronary arterial stenting. The subjects assigned were from the cities of Central (Novosibirsk, Kemerovo), Eastern (Irkutsk), Northern (Surgut) Siberia regions and from Moscow region. The mean age of patients enrolled was 63.9±10.9 years. Among the assigned subjects, the proportion of men accounted for 80% and women 20%. Results According to the results obtained in the present study, from 16% up to 27.5% of patients in different regions of Russia have at least one CYP2C19 “poor metabolizer” (PM) allele variant affecting clopidogrel metabolism and, therefore, suppressing its antiplatelet activity. CYP2C19*17 allele variant was identified with the frequency of 15.4% up to 33.3%. The study revealed the presence of statistically significant differences in CYP2C19*3 allele frequency between the Russian ethnic group patients from Eastern and Central Siberia (p=0.001; odds ratio=1.05 [95% confidence interval 1.01–1.09]). Conclusion The study revealed statistically significant differences between the allele frequencies in Eastern and Central Siberia, which can probably be caused by a considerable number of Buryats inhabiting Eastern Siberia. PMID:28442925

A new method for detecting, quantifying and monitoring diffuse contamination

NASA Astrophysics Data System (ADS)

Fabian, Karl; Reimann, Clemens; de Caritat, Patrice

2017-04-01

A new method is presented for detecting and quantifying diffuse contamination at the regional to continental scale. It is based on the analysis of cumulative distribution functions (CDFs) in cumulative probability (CP) plots for spatially representative datasets, preferably containing >1000 samples. Simulations demonstrate how different types of contamination influence elemental CDFs of different sample media. Contrary to common belief, diffuse contamination does not result in exceedingly high element concentrations in regional- to continental-scale datasets. Instead it produces a distinctive shift of concentrations in the background distribution of the studied element resulting in a steeper data distribution in the CP plot. Via either (1) comparing the distribution of an element in top soil samples to the distribution of the same element in bottom soil samples from the same area, taking soil forming processes into consideration, or (2) comparing the distribution of the contaminating element (e.g., Pb) to that of an element with a geochemically comparable behaviour but no contamination source (e.g., Rb or Ba in case of Pb), the relative impact of diffuse contamination on the element concentration can be estimated either graphically in the CP plot via a best fit estimate or quantitatively via a Kolmogorov-Smirnov or Cramer vonMiese test. This is demonstrated using continental-scale geochemical soil datasets from Europe, Australia, and the USA, and a regional scale dataset from Norway. Several different datasets from Europe deliver comparable results at regional to continental scales. The method is also suitable for monitoring diffuse contamination based on the statistical distribution of repeat datasets at the continental scale in a cost-effective manner.

1H-MRS in autism spectrum disorders: a systematic meta-analysis.

PubMed

Ipser, Jonathan C; Syal, Supriya; Bentley, Judy; Adnams, Colleen M; Steyn, Bennie; Stein, Dan J

2012-09-01

We conducted a systematic review and meta-analysis of proton magnetic resonance spectroscopy (1H-MRS) studies comparing autism spectrum disorder (ASD) patients with healthy controls, with the aim of profiling ASD-associated changes in the metabolites N-acetyl-aspartate (NAA) and Creatine (Cr). Meta-regression models of NAA and Cr levels were employed, using data from 20 eligible studies (N = 852), to investigate age-dependent differences in both global brain and region-specific metabolite levels, while controlling for measurement method (Cr-ratio versus absolute concentrations). Decreased NAA concentrations that were specific to children were found for whole-brain grey and white matter. In addition, a significant decrease in NAA was evident across age categories in the parietal cortex, the cerebellum, and the anterior cingulate cortex. Higher levels of Cr were observed for ASD adults than children in global grey matter, with specific increases for adults in the temporal lobe and decreased Cr in the occipital lobe in children. No differences were found for either NAA or Cr in the frontal lobes. These data provide some evidence that ASD is characterized by age-dependent fluctuations in metabolite levels across the whole brain and at the level of specific regions thought to underlie ASD-associated behavioural and affective deficits. Differences in Cr as a function of age and brain region suggests caution in the interpretation of Cr-based ratio measures of metabolites. Despite efforts to control for sources of heterogeneity, considerable variability in metabolite levels was observed in frontal and temporal regions, warranting further investigation.

Prospects for pro-environmental protein consumption in Europe: Cultural, culinary, economic and psychological factors.

PubMed

de Boer, Joop; Aiking, Harry

2018-02-01

The current ratio between plant and animal protein in the Western diet is causing serious threats to both public health and the environment. Healthy, pro-environmental protein consumption requires a transition to a diet with more plant protein and considerably less animal protein. The present paper focuses on the prospects of this transition by analyzing consumer responses to some key options in the context of regional differences across Europe. The aim is to assess how responses to the options might be shaped by 1) cultural, culinary and economic spatial gradients (including GDP per capita) at regional level and 2) differences in environmental friendly behavior and gender at individual level. The study, covering all EU members in 2012, compares regional level statistics (food supply data) with individual level statistics (consumer survey data) and vice-versa. The south-north latitude gradient showed a decreasing trend in vegetable and pulse protein supplies and, in parallel, a decreasing trend in positive consumer responses to the key options, probably due to differences in meal experiences. The west-east longitude gradient showed decreasing levels of animal protein supplies and GDP per capita. Individuals' willingness to do something positive for the environment and their gender played a weak but consistent role in the responses. To effectively stimulate diet changes, it is important to seek ways in which culinary and environmental aspects can complement each other and to ensure that diet changes do not depend solely on individual decisions but become an integral part of regional social processes. Copyright © 2017 Elsevier Ltd. All rights reserved.

Major Histocompatibility Complex Genes Map to Two Chromosomes in an Evolutionarily Ancient Reptile, the Tuatara Sphenodon punctatus

PubMed Central

Miller, Hilary C.; O’Meally, Denis; Ezaz, Tariq; Amemiya, Chris; Marshall-Graves, Jennifer A.; Edwards, Scott

2015-01-01

Major histocompatibility complex (MHC) genes are a central component of the vertebrate immune system and usually exist in a single genomic region. However, considerable differences in MHC organization and size exist between different vertebrate lineages. Reptiles occupy a key evolutionary position for understanding how variation in MHC structure evolved in vertebrates, but information on the structure of the MHC region in reptiles is limited. In this study, we investigate the organization and cytogenetic location of MHC genes in the tuatara (Sphenodon punctatus), the sole extant representative of the early-diverging reptilian order Rhynchocephalia. Sequencing and mapping of 12 clones containing class I and II MHC genes from a bacterial artificial chromosome library indicated that the core MHC region is located on chromosome 13q. However, duplication and translocation of MHC genes outside of the core region was evident, because additional class I MHC genes were located on chromosome 4p. We found a total of seven class I sequences and 11 class II β sequences, with evidence for duplication and pseudogenization of genes within the tuatara lineage. The tuatara MHC is characterized by high repeat content and low gene density compared with other species and we found no antigen processing or MHC framework genes on the MHC gene-containing clones. Our findings indicate substantial differences in MHC organization in tuatara compared with mammalian and avian MHCs and highlight the dynamic nature of the MHC. Further sequencing and annotation of tuatara and other reptile MHCs will determine if the tuatara MHC is representative of nonavian reptiles in general. PMID:25953959

Meta-analysis of diffusion metrics for the prediction of tumor grade in gliomas.

PubMed

Miloushev, V Z; Chow, D S; Filippi, C G

2015-02-01

Diffusion tensor metrics are potential in vivo quantitative neuroimaging biomarkers for the characterization of brain tumor subtype. This meta-analysis analyzes the ability of mean diffusivity and fractional anisotropy to distinguish low-grade from high-grade gliomas in the identifiable tumor core and the region of peripheral edema. A meta-analysis of articles with mean diffusivity and fractional anisotropy data for World Health Organization low-grade (I, II) and high-grade (III, IV) gliomas, between 2000 and 2013, was performed. Pooled data were analyzed by using the odds ratio and mean difference. Receiver operating characteristic analysis was performed for patient-level data. The minimum mean diffusivity of high-grade gliomas was decreased compared with low-grade gliomas. High-grade gliomas had decreased average mean diffusivity values compared with low-grade gliomas in the tumor core and increased average mean diffusivity values in the peripheral region. High-grade gliomas had increased FA values compared with low-grade gliomas in the tumor core, decreased values in the peripheral region, and a decreased fractional anisotropy difference between the tumor core and peripheral region. The minimum mean diffusivity differs significantly with respect to the World Health Organization grade of gliomas. Statistically significant effects of tumor grade on average mean diffusivity and fractional anisotropy were observed, supporting the concept that high-grade tumors are more destructive and infiltrative than low-grade tumors. Considerable heterogeneity within the literature may be due to systematic factors in addition to underlying lesion heterogeneity. © 2015 by American Journal of Neuroradiology.

Have precipitation extremes and annual totals been increasing in the world's dry regions over the last 60 years?

NASA Astrophysics Data System (ADS)

Sippel, Sebastian; Zscheischler, Jakob; Heimann, Martin; Lange, Holger; Mahecha, Miguel D.; van Oldenborgh, Geert Jan; Otto, Friederike E. L.; Reichstein, Markus

2017-01-01

Daily precipitation extremes and annual totals have increased in large parts of the global land area over the past decades. These observations are consistent with theoretical considerations of a warming climate. However, until recently these trends have not been shown to consistently affect dry regions over land. A recent study, published by Donat et al. (2016), now identified significant increases in annual-maximum daily extreme precipitation (Rx1d) and annual precipitation totals (PRCPTOT) in dry regions. Here, we revisit the applied methods and explore the sensitivity of changes in precipitation extremes and annual totals to alternative choices of defining a dry region (i.e. in terms of aridity as opposed to precipitation characteristics alone). We find that (a) statistical artifacts introduced by data pre-processing based on a time-invariant reference period lead to an overestimation of the reported trends by up to 40 %, and that (b) the reported trends of globally aggregated extremes and annual totals are highly sensitive to the definition of a dry region of the globe. For example, using the same observational dataset, accounting for the statistical artifacts, and based on different aridity-based dryness definitions, we find a reduction in the positive trend of Rx1d from the originally reported +1.6 % decade-1 to +0.2 to +0.9 % decade-1 (period changes for 1981-2010 averages relative to 1951-1980 are reduced to -1.32 to +0.97 % as opposed to +4.85 % in the original study). If we include additional but less homogenized data to cover larger regions, the global trend increases slightly (Rx1d: +0.4 to +1.1 % decade-1), and in this case we can indeed confirm (partly) significant increases in Rx1d. However, these globally aggregated estimates remain uncertain as considerable gaps in long-term observations in the Earth's arid and semi-arid regions remain. In summary, adequate data pre-processing and accounting for uncertainties regarding the definition of dryness are crucial to the quantification of spatially aggregated trends in precipitation extremes in the world's dry regions. In view of the high relevance of the question to many potentially affected stakeholders, we call for a well-reflected choice of specific data processing methods and the inclusion of alternative dryness definitions to guarantee that communicated results related to climate change be robust.

Isolated Traumatic Bilateral First Rib Fracture: A Rare Entity

PubMed Central

Chatterjee, Souvik; Dey, Rajesh; Ray, Ramdip; Sinha, Santanu

2011-01-01

Since the first rib is protected very well by the overlying soft tissue and bones, its fracture is a major injury and a considerable force is required to do it. Therefore, an isolated fracture of this rib is unusual. A 28-year-old healthy female had an accident while crossing the road and a heavy object fell on her. She had severe pain behind her clavicle region and was immediately hospitalized and examined. Thorough clinical examination and different relevant investigations surprisingly disclosed isolated bilateral first rib fracture which is a very rare clinical condition. PMID:25191390

Anesthetic management of achondroplastic dwarf undergoing cesarean section--a case report.

PubMed

Cevik, Banu; Colakoğlu, Serhan

2010-10-01

There are more than 100 different types of dwarfism. Achondroplasia is the most common of these conditions. The aim of this report is to describe the anesthetic management of these patient, discussing the anesthetic considerations and emphasizing the difficulties encountered. A 32-year-old achondroplastic parturient underwent cesarean section under general anesthesia. We did not encounter problems related with airway management. The operation went without any complication. There are risks for both regional and general anesthesia in achondroplastic patients. The most important point is the careful preoperative assessment. Anesthesia plan should be specified to individual basis.

The HZE radiation problem. [highly-charged energetic galactic cosmic rays

NASA Technical Reports Server (NTRS)

Schimmerling, Walter

1990-01-01

Radiation-exposure limits have yet to be established for missions envisioned in the framework of the Space Exploration Initiative. The radiation threat outside the earth's magnetosphere encompasses protons from solar particle events and the highly charged energetic particles constituting galactic cosmic rays; radiation biology entails careful consideration of the extremely nonuniform patterns of such particles' energy deposition. The ability to project such biological consequences of exposure to energetic particles as carcinogenicity currently involves great uncertainties from: (1) different regions of space; (2) the effects of spacecraft structures; and (3) the dose-effect relationships of single traversals of energetic particles.

Karyological features of wild and cultivated forms of myrtle (Myrtus communis, Myrtaceae).

PubMed

Serçe, S; Ekbiç, E; Suda, J; Gündüz, K; Kiyga, Y

2010-03-09

Myrtle is an evergreen shrub or small tree widespread throughout the Mediterranean region. In Turkey, both cultivated and wild forms, differing in plant and fruit size and fruit composition, can be found. These differences may have resulted from the domestication of the cultivated form over a long period of time. We investigated whether wild and cultivated forms of myrtle differ in karyological features (i.e., number of somatic chromosomes and relative genome size). We sampled two wild forms and six cultivated types of myrtle. All the samples had the same chromosome number (2n = 2x = 22). The results were confirmed by 4',6-diamidino-2-phenylindole (DAPI) flow cytometry. Only negligible variation (approximately 3%) in relative fluorescence intensity was observed among the different myrtle accessions, with wild genotypes having the smallest values. We concluded that despite considerable morphological differentiation, cultivated and wild myrtle genotypes in Turkey have similar karyological features.

Design of the advanced regional aircraft, the DART-75

NASA Technical Reports Server (NTRS)

Elliot, Steve; Gislason, Jason; Huffstetler, Mark; Mann, Jon; Withers, Ashley; Zimmerman, Mark

1992-01-01

The need for regional aircraft stems from the problem of hub airport congestion. Regional travel will allow a passenger to commute from one spoke city to another spoke city without entering the congested hub airport. In addition, those people traveling longer routes may begin the flight at home instead of traveling to the hub airport. At this time, there is no American aerospace company that produces a regional transport for under 100 passengers. The intention of the Developmental Advanced Regional Transport (DART-75) is to fill this void with a modern, efficient regional aircraft. This design achieves the efficiency through a number of advanced features including three lifting surfaces, partial composite construction, and an advanced engine design. Efficiency is not the only consideration. Structural integrity, fatigue life, ease of maintenance, passenger comfort and convenience, and environmental aspects must all be considered. These factors force the design team to face many tradeoffs that are studied to find the best solution. The final consideration that cannot be overlooked is that of cost. The DART-75 is a 75-passenger medium-range regional transport intended for spoke-to-spoke, spoke-to-hub, and some hub-to-hub operations. Included are the general descriptions of the structures, weight and balance, stability and control, performance, and engine design.

Regional risk assessment for contaminated sites part 2: ranking of potentially contaminated sites.

PubMed

Pizzol, Lisa; Critto, Andrea; Agostini, Paola; Marcomini, Antonio

2011-11-01

Environmental risks are traditionally assessed and presented in non spatial ways although the heterogeneity of the contaminants spatial distributions, the spatial positions and relations between receptors and stressors, as well as the spatial distribution of the variables involved in the risk assessment, strongly influence exposure estimations and hence risks. Taking into account spatial variability is increasingly being recognized as a further and essential step in sound exposure and risk assessment. To address this issue an innovative methodology which integrates spatial analysis and a relative risk approach was developed. The purpose of this methodology is to prioritize sites at regional scale where a preliminary site investigation may be required. The methodology aimed at supporting the inventory of contaminated sites was implemented within the spatial decision support sYstem for Regional rIsk Assessment of DEgraded land, SYRIADE, and was applied to the case-study of the Upper Silesia region (Poland). The developed methodology and tool are both flexible and easy to adapt to different regional contexts, allowing the user to introduce the regional relevant parameters identified on the basis of user expertise and regional data availability. Moreover, the used GIS functionalities, integrated with mathematical approaches, allow to take into consideration, all at once, the multiplicity of sources and impacted receptors within the region of concern, to assess the risks posed by all contaminated sites in the region and, finally, to provide a risk-based ranking of the potentially contaminated sites. Copyright © 2011. Published by Elsevier Ltd.

Governance factors in the identification of global conservation priorities for mammals

PubMed Central

Eklund, Johanna; Arponen, Anni; Visconti, Piero; Cabeza, Mar

2011-01-01

Global conservation priorities have often been identified based on the combination of species richness and threat information. With the development of the field of systematic conservation planning, more attention has been given to conservation costs. This leads to prioritizing developing countries, where costs are generally low and biodiversity is high. But many of these countries have poor governance, which may result in ineffective conservation or in larger costs than initially expected. We explore how the consideration of governance affects the selection of global conservation priorities for the world's mammals in a complementarity-based conservation prioritization. We use data on Control of Corruption (Worldwide Governance Indicators project) as an indicator of governance effectiveness, and gross domestic product per capita as an indicator of cost. We show that, while core areas with high levels of endemism are always selected as important regardless of governance and cost values, there are clear regional differences in selected sites when biodiversity, cost or governance are taken into account separately. Overall, the analysis supports the concentration of conservation efforts in most of the regions generally considered of high priority, but stresses the need for different conservation approaches in different continents owing to spatial patterns of governance and economic development. PMID:21844045

Parallel processing considerations for image recognition tasks

NASA Astrophysics Data System (ADS)

Simske, Steven J.

2011-01-01

Many image recognition tasks are well-suited to parallel processing. The most obvious example is that many imaging tasks require the analysis of multiple images. From this standpoint, then, parallel processing need be no more complicated than assigning individual images to individual processors. However, there are three less trivial categories of parallel processing that will be considered in this paper: parallel processing (1) by task; (2) by image region; and (3) by meta-algorithm. Parallel processing by task allows the assignment of multiple workflows-as diverse as optical character recognition [OCR], document classification and barcode reading-to parallel pipelines. This can substantially decrease time to completion for the document tasks. For this approach, each parallel pipeline is generally performing a different task. Parallel processing by image region allows a larger imaging task to be sub-divided into a set of parallel pipelines, each performing the same task but on a different data set. This type of image analysis is readily addressed by a map-reduce approach. Examples include document skew detection and multiple face detection and tracking. Finally, parallel processing by meta-algorithm allows different algorithms to be deployed on the same image simultaneously. This approach may result in improved accuracy.

Relation Decomposing between Urbanization and Consumption of Water-Energy Sources

NASA Astrophysics Data System (ADS)

Wang, Y.; Xiao, W.; Wang, Y.; Zhao, Y.; Wang, J., , Dr; Jiang, D.; Wang, H.

2017-12-01

Abstract: Water resources and energy, important subsystems of city, are the basic guarantee for the normal operation of city, which play an important role to brace the urbanization. The interdependence between them are increasing along with the rapid development of China's economy. The relationship between urbanization and consumption of energy and water have become the focal point of the scholars, but the research have more attention to the impact of urbanization on two subsystems separately, and do not reveal the effects of urbanization on the water-energy nexus. Thus, there is little consideration upon the different characteristics of China's several regions in water and energy consumption in urbanization. In this paper, the STIRPAT model is built to reveal the relationship between urbanization and the consumption of water and energy. Also, the influence of urbanization on different main body of water and energy consumption are discussed. The different regional main factors of water and energy in the process of urbanization are identified through water and energy panel data of China's thirty provinces. Finally, through the regression analysis of total water consumption data of agriculture, industry, service industry with total energy consumption data, the relationship of water and energy in the process of urban development are analyzed.

Genetic Characterization of Turkish Snake Melon (Cucumis melo L. subsp. melo flexuosus Group) Accessions Revealed by SSR Markers.

PubMed

Solmaz, Ilknur; Kacar, Yildiz Aka; Simsek, Ozhan; Sari, Nebahat

2016-08-01

Snake melon is an important cucurbit crop especially in the Southeastern and the Mediterranean region of Turkey. It is consumed as fresh or pickled. The production is mainly done with the local landraces in the country. Turkey is one of the secondary diversification centers of melon and possesses valuable genetic resources which have different morphological characteristics in case of snake melon. Genetic diversity of snake melon genotypes collected from different regions of Turkey and reference genotypes obtained from World Melon Gene Bank in Avignon-France was examined using 13 simple sequence repeat (SSR) markers. A total of 69 alleles were detected, with an average of 5.31 alleles per locus. The polymorphism information content of SSR markers ranged from 0.19 to 0.57 (average 0.38). Based on cluster analysis, two major groups were defined. The first major group included only one accession (61), while the rest of all accessions grouped in the second major group and separated into different sub-clusters. Based on SSR markers, cluster analysis indicated that considerably high genetic variability exists among the examined accessions; however, Turkish snake melon accessions were grouped together with the reference snake melon accessions.

Governance factors in the identification of global conservation priorities for mammals.

PubMed

Eklund, Johanna; Arponen, Anni; Visconti, Piero; Cabeza, Mar

2011-09-27

Global conservation priorities have often been identified based on the combination of species richness and threat information. With the development of the field of systematic conservation planning, more attention has been given to conservation costs. This leads to prioritizing developing countries, where costs are generally low and biodiversity is high. But many of these countries have poor governance, which may result in ineffective conservation or in larger costs than initially expected. We explore how the consideration of governance affects the selection of global conservation priorities for the world's mammals in a complementarity-based conservation prioritization. We use data on Control of Corruption (Worldwide Governance Indicators project) as an indicator of governance effectiveness, and gross domestic product per capita as an indicator of cost. We show that, while core areas with high levels of endemism are always selected as important regardless of governance and cost values, there are clear regional differences in selected sites when biodiversity, cost or governance are taken into account separately. Overall, the analysis supports the concentration of conservation efforts in most of the regions generally considered of high priority, but stresses the need for different conservation approaches in different continents owing to spatial patterns of governance and economic development.

Modeling wetland plant community response to assess water-level regulation scenarios in the Lake Ontario-St. Lawrence River basin

USGS Publications Warehouse

Hudon, Christiane; Wilcox, Douglas; Ingram, Joel

2006-01-01

The International Joint Commission has recently completed a five-year study (2000-2005) to review the operation of structures controlling the flows and levels of the Lake Ontario - St. Lawrence River system. In addition to addressing the multitude of stakeholder interests, the regulation plan review also considers environmental sustainability and integrity of wetlands and various ecosystem components. The present paper outlines the general approach, scientific methodology and applied management considerations of studies quantifying the relationships between hydrology and wetland plant assemblages (% occurrence, surface area) in Lake Ontario and the Upper and Lower St. Lawrence River. Although similar study designs were used across the study region, different methodologies were required that were specifically adapted to suit the important regional differences between the lake and river systems, range in water-level variations, and confounding factors (geomorphic types, exposure, sediment characteristics, downstream gradient of water quality, origin of water masses in the Lower River). Performance indicators (metrics), such as total area of wetland in meadow marsh vegetation type, that link wetland response to water levels will be used to assess the effects of different regulation plans under current and future (climate change) water-supply scenarios.

CO2 Fluxes Associated with Soil Organic C Stock Changes in the Mid-Continent Region of the U.S.

NASA Astrophysics Data System (ADS)

Ogle, S. M.; Paustian, K.; Easter, M.; Killian, K.; Williams, S.

2005-12-01

Regional CO2 sources and sinks need to be quantified in the terrestrial biosphere for basic understanding and policy development. Our objective was to quantify CO2 fluxes for the Mid-Continent Region of the US, including Iowa and neighboring areas in adjacent states, using a "bottom-up" simulation modeling approach. Soils represent an important potential sink for this largely agricultural region because of limited potential for CO2 uptake and storage in woody biomass. SOC stocks were estimated to have increased during the 1990s at a rate equivalent to 3.81 Tg CO2 yr-1, but with considerable sub-regional variation due to differences in land use and management patterns. Sinks were driven by conservation tillage adoption, enrollment in the Conservation Reserve Program, and conversion of annual crops to continuous hay or pasture. The dominant source of CO2 from soils in the Mid-Continent Region was attributed to drainage and cultivation of organic soils. Uncertainties in regional estimates were determined using a Monte Carlo Analysis and empirically-based uncertainty estimator, and the largest uncertainties were associated with estimating the fluxes from drained organic soils. A major research challenge is to verify the accuracy of these rates using "top-down" atmospheric budgets that are independent of the bottom-up inventory.

Methods for recording and measuring tonic GABAA receptor-mediated inhibition

PubMed Central

Bright, Damian P.; Smart, Trevor G.

2013-01-01

Tonic inhibitory conductances mediated by GABAA receptors have now been identified and characterized in many different brain regions. Most experimental studies of tonic GABAergic inhibition have been carried out using acute brain slice preparations but tonic currents have been recorded under a variety of different conditions. This diversity of recording conditions is likely to impact upon many of the factors responsible for controlling tonic inhibition and can make comparison between different studies difficult. In this review, we will firstly consider how various experimental conditions, including age of animal, recording temperature and solution composition, are likely to influence tonic GABAA conductances. We will then consider some technical considerations related to how the tonic conductance is measured and subsequently analyzed, including how the use of current noise may provide a complementary and reliable method for quantifying changes in tonic current. PMID:24367296

A virtual intranet and data-warehousing for healthcare co-operation.

PubMed

Kerkri, E M; Quantin, C; Grison, T; Allaert, F A; Tchounikine, A; Yétongnon, K

2001-01-01

As patient's medical data is disseminated in different health structures, developing a medical or epidemiological patient-oriented data warehouse has some specific requirements compared to intra healthcare structure data-warehousing projects. The difference is that the healthcare structures implicated in a patient-oriented data warehouse project require some considerations about the confidentiality of the patient data and of the activities of healthcare structures. Building a data-warehousing system at a regional level, for example in cancerology, requires the participation of all concerned health structures, as well as different health professionals. The heterogeneity of sources medical data of has to be taken into account for choosing between several organizational configurations of the data warehousing system. In top of data warehousing, we propose a concept of Virtual Intranet, which provides a solution to the problem of medical information security arising from heterogeneous sources.

Spatial Sampling of Weather Data for Regional Crop Yield Simulations

NASA Technical Reports Server (NTRS)

Van Bussel, Lenny G. J.; Ewert, Frank; Zhao, Gang; Hoffmann, Holger; Enders, Andreas; Wallach, Daniel; Asseng, Senthold; Baigorria, Guillermo A.; Basso, Bruno; Biernath, Christian;

33 CFR 332.1 - Purpose and general considerations.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., mitigation banks, and in-lieu fee mitigation to offset unavoidable impacts to waters of the United States... available credits and opportunities for mitigation, provide for regional variations in wetland conditions... and the Corps at the national or regional level. No modifications to the basic application, meaning...

40 CFR 230.91 - Purpose and general considerations.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., mitigation banks, and in-lieu fee mitigation to offset unavoidable impacts to waters of the United States..., provide for regional variations in wetland conditions, functions, and values, and apply equivalent... national or regional level. No modifications to the basic application, meaning, or intent of this subpart...

33 CFR 332.1 - Purpose and general considerations.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., mitigation banks, and in-lieu fee mitigation to offset unavoidable impacts to waters of the United States... available credits and opportunities for mitigation, provide for regional variations in wetland conditions... and the Corps at the national or regional level. No modifications to the basic application, meaning...

10 CFR 960.3-1-3 - Regionality.

Code of Federal Regulations, 2010 CFR

2010-01-01

... REPOSITORY Implementation Guidelines § 960.3-1-3 Regionality. In making site recommendations for repository development after the site for the first repository has been recommended, the Secretary shall give due... repositories. Such consideration shall take into account the proximity of sites to locations at which waste is...

Quantitative and qualitative differences in use and trends of hematopoietic stem cell transplantation: a Global Observational Study

PubMed Central

Gratwohl, Alois; Baldomero, Helen; Gratwohl, Michael; Aljurf, Mahmoud; Bouzas, Luis Fernando; Horowitz, Mary; Kodera, Yoshihisa; Lipton, Jeff; Iida, Minako; Pasquini, Marcelo C.; Passweg, Jakob; Szer, Jeff; Madrigal, Alejandro; Frauendorfer, Karl; Niederwieser, Dietger

2013-01-01

Fifty-five years after publication of the first hematopoietic stem cell transplantation this technique has become an accepted treatment option for defined hematologic and non-hematologic disorders. There is considerable interest in understanding differences in its use and trends on a global level and the macro-economic factors associated with these differences. Data on the numbers of hematopoietic stem cell transplants performed in the 3-year period 2006–2008 were obtained from Worldwide Network for Blood and Marrow Transplantation member registries and from transplant centers in countries without registries. Population and macro-economic data were collected from the World Bank and from the International Monetary Fund. Transplant rates were analyzed by indication, donor type, country, and World Health Organization regional offices areas and related to selected health care indicators using single and multiple linear regression analyses. Data from a total of 146,808 patients were reported by 1,411 teams from 72 countries over five continents. The annual number of transplants increased worldwide with the highest relative increase in the Asia Pacific region. Transplant rates increased preferentially in high income countries (P=0.02), not in low or medium income countries. Allogeneic transplants increased for myelodysplasia, chronic lymphocytic leukemia, acute leukemias, and non-malignant diseases but decreased for chronic myelogenous leukemia. Autologous transplants increased for autoimmune and lymphoproliferative diseases but decreased for leukemias and solid tumors. Transplant rates (P<0.01), donor type (P<0.01) aand disease indications (P<0.01) differed significantly between countries and regions. Transplant rates were associated with Gross National Income/capita (P<0.01) but showed a wide variation of explanatory content by donor type, disease indication and World Health Organization region. Hematopoietic stem cell transplantation activity is increasing worldwide. The preferential increase in high income countries, the widening gap between low and high income countries and the significant regional differences suggest that different strategies are required in individual countries to foster hematopoietic stem cell transplantation as an efficient and cost-effective treatment modality. PMID:23508009

NONLINEAR FORCE-FREE FIELD MODELING OF A SOLAR ACTIVE REGION USING SDO/HMI AND SOLIS/VSM DATA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thalmann, J. K.; Wiegelmann, T.; Pietarila, A.

2012-08-15

We use SDO/HMI and SOLIS/VSM photospheric magnetic field measurements to model the force-free coronal field above a solar active region, assuming magnetic forces dominate. We take measurement uncertainties caused by, e.g., noise and the particular inversion technique, into account. After searching for the optimum modeling parameters for the particular data sets, we compare the resulting nonlinear force-free model fields. We show the degree of agreement of the coronal field reconstructions from the different data sources by comparing the relative free energy content, the vertical distribution of the magnetic pressure, and the vertically integrated current density. Though the longitudinal and transversemore » magnetic flux measured by the VSM and HMI is clearly different, we find considerable similarities in the modeled fields. This indicates the robustness of the algorithm we use to calculate the nonlinear force-free fields against differences and deficiencies of the photospheric vector maps used as an input. We also depict how much the absolute values of the total force-free, virial, and the free magnetic energy differ and how the orientation of the longitudinal and transverse components of the HMI- and VSM-based model volumes compare to each other.« less

At-Risk Youth: Considerations for State-Level Policymakers, Including a Summary of Recent State-Level Actions in the Region.

ERIC Educational Resources Information Center

Regional Laboratory for Educational Improvement of the Northeast & Islands, Andover, MA.

In response to the growing dropout problem, most of the northeastern states (and islands) and many of their local districts have implemented policies and programs designed to reduce the number of students leaving school. This paper presents some observations, culled from various reports, for policymakers' consideration. Section I offers a set of…

An Analysis of Pre-Service Science Teachers' Moral Considerations about Environment and Their Attitudes towards Sustainable Environment

ERIC Educational Resources Information Center

Alpak-Tunç, Gizem; Yenice, Nilgün

2017-01-01

This study aims at analysing the moral considerations of pre-service science teachers about environment and their attitudes towards sustainable environment. It was carried out during the school year of 2014-2015 with 1438 pre-service science teachers attending public universities in the Aegean region of Turkey. The data of the study were collected…

Upgrades to the REA method for producing probabilistic climate change projections

NASA Astrophysics Data System (ADS)

Xu, Ying; Gao, Xuejie; Giorgi, Filippo

2010-05-01

We present an augmented version of the Reliability Ensemble Averaging (REA) method designed to generate probabilistic climate change information from ensembles of climate model simulations. Compared to the original version, the augmented one includes consideration of multiple variables and statistics in the calculation of the performance-based weights. In addition, the model convergence criterion previously employed is removed. The method is applied to the calculation of changes in mean and variability for temperature and precipitation over different sub-regions of East Asia based on the recently completed CMIP3 multi-model ensemble. Comparison of the new and old REA methods, along with the simple averaging procedure, and the use of different combinations of performance metrics shows that at fine sub-regional scales the choice of weighting is relevant. This is mostly because the models show a substantial spread in performance for the simulation of precipitation statistics, a result that supports the use of model weighting as a useful option to account for wide ranges of quality of models. The REA method, and in particular the upgraded one, provides a simple and flexible framework for assessing the uncertainty related to the aggregation of results from ensembles of models in order to produce climate change information at the regional scale. KEY WORDS: REA method, Climate change, CMIP3

A new theoretical model for transmembrane potential and ion currents induced in a spherical cell under low frequency electromagnetic field.

PubMed

Zheng, Yu; Gao, Yang; Chen, Ruijuan; Wang, Huiquan; Dong, Lei; Dou, Junrong

2016-10-01

Time-varying electromagnetic fields (EMF) can induce some physiological effects in neuronal tissues, which have been explored in many applications such as transcranial magnetic stimulation. Although transmembrane potentials and induced currents have already been the subjects of many theoretical studies, most previous works about this topic are mainly completed by utilizing Maxwell's equations, often by solving a Laplace equation. In previous studies, cells were often considered to be three-compartment models with different electroconductivities in different regions (three compartments are often intracellular regions, membrane, and extracellular regions). However, models like that did not take dynamic ion channels into consideration. Therefore, one cannot obtain concrete ionic current changes such as potassium current change or sodium current change by these models. The aim of the present work is to present a new and more detailed model for calculating transmembrane potentials and ionic currents induced by time-varying EMF. Equations used in the present paper originate from Nernst-Plank equations, which are ionic current-related equations. The main work is to calculate ionic current changes induced by EMF exposure, and then transmembrane potential changes are calculated with Hodgkin-Huxley model. Bioelectromagnetics. 37:481-492, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Optical investigation of variability in body region dependent transcutaneous oxygen saturation

NASA Astrophysics Data System (ADS)

Philimon, Sheena P.; Huong, Audrey K. C.; Hafizah, W. M.; Ong, P. E.; Ngu, Xavier T. I.

2016-11-01

This paper presents the use of multispectral imaging system to investigate variability in transcutaneous oxygen saturation (StO2) amongst different individuals and at different skin sites. Noncontact reflectance data are collected from central forehead, posterior forearm, thenar region of palm and proximal ankle of three healthy Asians. The prediction of the required StO2 value is via fitting Extended Modified Lambert (EMLB) model to the measured attenuation data using extinction coefficient of hemoglobin components in the wavelength range of 520 - 600 nm as its priori knowledge. The obtained results revealed a relatively high mean StO2 of 54 ± 1.9% at the palm of the hand site. This is followed by measurement at foot ankle and forehead with StO2 of 52.3 ± 2.4% and 51.2 ± 7.7%, respectively. Meanwhile the lowest reading of StO2 of 48.8 ± 5.1% is observed at the posterior forearm. Based on these findings, this work concluded that palm of the hand would provide considerably consistent measurement of StO2 among individuals. This is largely owing to the higher density of circulatory anastomosis at this skin site. This implied viability of using the developed strategy in the studies of microcirculation mechanism especially on wound at this skin region.

The potential distribution of Phlebotomus papatasi (Diptera: Psychodidae) in Libya based on ecological niche model.

PubMed

Abdel-Dayem, M S; Annajar, B B; Hanafi, H A; Obenauer, P J

2012-05-01

The increased cases of cutaneous leishmaniasis vectored by Phlebotomus papatasi (Scopoli) in Libya have driven considerable effort to develop a predictive model for the potential geographical distribution of this disease. We collected adult P. papatasi from 17 sites in Musrata and Yefern regions of Libya using four different attraction traps. Our trap results and literature records describing the distribution of P. papatasi were incorporated into a MaxEnt algorithm prediction model that used 22 environmental variables. The model showed a high performance (AUC = 0.992 and 0.990 for training and test data, respectively). High suitability for P. papatasi was predicted to be largely confined to the coast at altitudes <600 m. Regions south of 300 degrees N latitude were calculated as unsuitable for this species. Jackknife analysis identified precipitation as having the most significant predictive power, while temperature and elevation variables were less influential. The National Leishmaniasis Control Program in Libya may find this information useful in their efforts to control zoonotic cutaneous leishmaniasis. Existing records are strongly biased toward a few geographical regions, and therefore, further sand fly collections are warranted that should include documentation of such factors as soil texture and humidity, land cover, and normalized difference vegetation index (NDVI) data to increase the model's predictive power.

Crustal structure in high deformation zones: Insights from gravimetric and magnetometric studies in the Guacha Corral shear zone (Eastern Sierras Pampeanas, Argentina)

NASA Astrophysics Data System (ADS)

Radice, Stefania; Lince Klinger, Federico; Maffini, M. Natalia; Pinotti, Lucio P.; Demartis, Manuel; D´Eramo, Fernando J.; Giménez, Mario; Coniglio, Jorge E.

2018-03-01

The Guacha Corral shear zone (GCSZ) is represented by mylonites that were developed under amphibolites facies conditions from migmatitic protoliths. In this contribution, geophysical, petrological and structural data were combined to determine the 3D geometry of the GCSZ. New gravimetric, magnetometric and structural studies, along an E-W profile, were integrated with existing magnetotelluric and seismological data from a representative regional database of the Eastern Sierras Pampeanas. The zonation of different fabrics across the GCSZ suggests that the pre-existing heterogeneities of the protoliths played a key role in governing the degree of metamorphism of different regions. The low gravity anomalies observed in the GCSZ suggest a transitional boundary zone between the migmatitic and mylonitic domains, where highly deformed shear bands are interspersed with undeformed rocks, presenting gradual contacts. The mylonites in this shear zone show a considerably reduced density when compared to the migmatite protoliths. The density of the rocks gradually increases with depth until it reaches that of the protolith. These changes in the gravity values in response to density changes allowed us to infer a listric geometry at depth of the GCSZ. Low gravity anomalies in the profiles, in regions where high density rocks (migmatites) outcrop at the surface, modeled as buried granitic plutons.

Spectroscopic investigation of herpes simplex viruses infected cells and their response to antiviral therapy

NASA Astrophysics Data System (ADS)

Erukhimovitch, Vitaly; Talyshinsky, Marina; Souprun, Yelena; Huleihel, Mahmoud

2006-07-01

In the present study, we used microscopic Fourier transform infrared spectroscopy (FTIR) to evaluate the antiviral activity of known antiviral agents against herpes viruses. The antiviral activity of Caffeic acid phenethyl ester (CAPE) (which is an active compound of propolis) against herpes simplex type 1 and 2 was examined in cell culture. The advantage of microscopic FTIR spectroscopy over conventional FTIR spectroscopy is that it facilitates inspection of restricted regions of cell culture or tissue. Our results showed significant spectral differences at early stages of infection between infected and non-infected cells, and between infected cells treated with the used antiviral agent and those not treated. In infected cells, there was a considerable increase in phosphate levels. Our results show that treatment with used antiviral agent considerably abolish the spectral changes induced by the viral infection. In addition, it is possible to track by FTIR microscopy method the deferential effect of various doses of the drug.

Improving regulatory capacity to manage risks associated with trade agreements.

PubMed

Walls, Helen L; Smith, Richard D; Drahos, Peter

2015-03-21

Modern trade negotiations have delivered a plethora of bilateral and regional preferential trade agreements (PTAs), which involve considerable risk to public health, thus placing demands on governments to strengthen administrative regulatory capacities in regard to the negotiation, implementation and on-going management of PTAs. In terms of risk management, the administrative regulatory capacity requisite for appropriate negotiation of PTAs is different to that for the implementation or on-going management of PTAs, but at all stages the capacity needed is expensive, skill-intensive and requires considerable infrastructure, which smaller and poorer states especially struggle to find. It is also a task generally underestimated. If states do not find ways to increase their capacities then PTAs are likely to become much greater drivers of health inequities. Developing countries especially struggle to find this capacity. In this article we set out the importance of administrative regulatory capacity and coordination to manage the risks to public health associated with PTAs, and suggest ways countries can improve their capacity.

Representative sets of design hydrographs for ungauged catchments: A regional approach using probabilistic region memberships

NASA Astrophysics Data System (ADS)

Brunner, Manuela Irene; Seibert, Jan; Favre, Anne-Catherine

2018-02-01

Traditional design flood estimation approaches have focused on peak discharges and have often neglected other hydrograph characteristics such as hydrograph volume and shape. Synthetic design hydrograph estimation procedures overcome this deficiency by jointly considering peak discharge, hydrograph volume, and shape. Such procedures have recently been extended to allow for the consideration of process variability within a catchment by a flood-type specific construction of design hydrographs. However, they depend on observed runoff time series and are not directly applicable in ungauged catchments where such series are not available. To obtain reliable flood estimates, there is a need for an approach that allows for the consideration of process variability in the construction of synthetic design hydrographs in ungauged catchments. In this study, we therefore propose an approach that combines a bivariate index flood approach with event-type specific synthetic design hydrograph construction. First, regions of similar flood reactivity are delineated and a classification rule that enables the assignment of ungauged catchments to one of these reactivity regions is established. Second, event-type specific synthetic design hydrographs are constructed using the pooled data divided by event type from the corresponding reactivity region in a bivariate index flood procedure. The approach was tested and validated on a dataset of 163 Swiss catchments. The results indicated that 1) random forest is a suitable classification model for the assignment of an ungauged catchment to one of the reactivity regions, 2) the combination of a bivariate index flood approach and event-type specific synthetic design hydrograph construction enables the consideration of event types in ungauged catchments, and 3) the use of probabilistic class memberships in regional synthetic design hydrograph construction helps to alleviate the problem of misclassification. Event-type specific synthetic design hydrograph sets enable the inclusion of process variability into design flood estimation and can be used as a compromise between single best estimate synthetic design hydrographs and continuous simulation studies.

Thermal coefficients of technology assimilation by natural systems

NASA Technical Reports Server (NTRS)

Mueller, R. F.

1971-01-01

Estimates of thermal coefficients of the rates of technology assimilation processes was made. Consideration of such processes as vegetation and soil recovery and pollution assimilation indicates that these processes proceed ten to several hundred times more slowly in earth's cold regions than in temperate regions. It was suggested that these differential assimilation rates are important data in planning for technological expansion in Arctic regions.

Regional Development Impacts Multi-Regional - Multi-Industry Model (MRMI) Users Manual,

DTIC Science & Technology

1982-09-01

indicators, described in Chapter 2, are estimated as well. Finally, MRMI is flexible, as it can incorporate alternative macroeconomic , national inter...national and regional economic contexts and data sources for estimating macroeconomic and direct impacts data. Considerations for ensuring consistency...Chapter 4 is devoted to model execution and the interpretation of its output. As MRMI forecasts are based upon macroeconomic , national inter-industry

Methodological Considerations in Researching Community Services in the Northeast. A Northeast Regional Community Services Study. New Jersey Agricultural Experiment Station Bulletin 836, September 1975.

ERIC Educational Resources Information Center

Derr, Donn A., Ed.; And Others

Documenting several elements relative to regional research on community services in 10 northeastern states as experienced in the U.S. Department of Agriculture's Regional Research Project NE-77 (1971), this monograph represents the NE-77 technical committee's effort to identify basic research issues re: the delivery of community services in rural…

Consequences of Global Warming of 1.5 °C and 2 °C for Regional Temperature and Precipitation Changes in the Contiguous United States

PubMed Central

Bradley, Raymond S.

2017-01-01

The differential warming of land and ocean leads to many continental regions in the Northern Hemisphere warming at rates higher than the global mean temperature. Adaptation and conservation efforts will, therefore, benefit from understanding regional consequences of limiting the global mean temperature increase to well below 2°C above pre-industrial levels, a limit agreed upon at the United Nations Climate Summit in Paris in December 2015. Here, we analyze climate model simulations from the Coupled Model Intercomparison Project Phase 5 (CMIP5) to determine the timing and magnitude of regional temperature and precipitation changes across the contiguous United States (US) for global warming of 1.5 and 2°C and highlight consensus and uncertainties in model projections and their implications for making decisions. The regional warming rates differ considerably across the contiguous US, but all regions are projected to reach 2°C about 10-20 years before the global mean temperature. Although there is uncertainty in the timing of exactly when the 1.5 and 2°C thresholds will be crossed regionally, over 80% of the models project at least 2°C warming by 2050 for all regions for the high emissions scenario. This threshold-based approach also highlights regional variations in the rate of warming across the US. The fastest warming region in the contiguous US is the Northeast, which is projected to warm by 3°C when global warming reaches 2°C. The signal-to-noise ratio calculations indicate that the regional warming estimates remain outside the envelope of uncertainty throughout the twenty-first century, making them potentially useful to planners. The regional precipitation projections for global warming of 1.5°C and 2°C are uncertain, but the eastern US is projected to experience wetter winters and the Great Plains and the Northwest US are projected to experience drier summers in the future. The impact of different scenarios on regional precipitation projections is negligible throughout the twenty-first century compared to uncertainties associated with internal variability and model diversity. PMID:28076360

Consequences of Global Warming of 1.5 °C and 2 °C for Regional Temperature and Precipitation Changes in the Contiguous United States.

PubMed

Karmalkar, Ambarish V; Bradley, Raymond S

2017-01-01

The differential warming of land and ocean leads to many continental regions in the Northern Hemisphere warming at rates higher than the global mean temperature. Adaptation and conservation efforts will, therefore, benefit from understanding regional consequences of limiting the global mean temperature increase to well below 2°C above pre-industrial levels, a limit agreed upon at the United Nations Climate Summit in Paris in December 2015. Here, we analyze climate model simulations from the Coupled Model Intercomparison Project Phase 5 (CMIP5) to determine the timing and magnitude of regional temperature and precipitation changes across the contiguous United States (US) for global warming of 1.5 and 2°C and highlight consensus and uncertainties in model projections and their implications for making decisions. The regional warming rates differ considerably across the contiguous US, but all regions are projected to reach 2°C about 10-20 years before the global mean temperature. Although there is uncertainty in the timing of exactly when the 1.5 and 2°C thresholds will be crossed regionally, over 80% of the models project at least 2°C warming by 2050 for all regions for the high emissions scenario. This threshold-based approach also highlights regional variations in the rate of warming across the US. The fastest warming region in the contiguous US is the Northeast, which is projected to warm by 3°C when global warming reaches 2°C. The signal-to-noise ratio calculations indicate that the regional warming estimates remain outside the envelope of uncertainty throughout the twenty-first century, making them potentially useful to planners. The regional precipitation projections for global warming of 1.5°C and 2°C are uncertain, but the eastern US is projected to experience wetter winters and the Great Plains and the Northwest US are projected to experience drier summers in the future. The impact of different scenarios on regional precipitation projections is negligible throughout the twenty-first century compared to uncertainties associated with internal variability and model diversity.

Influence of synoptic condition and holiday effects on VOCs and ozone production in the Yangtze River Delta region, China

NASA Astrophysics Data System (ADS)

Xu, Zhengning; Huang, Xin; Nie, Wei; Chi, Xuguang; Xu, Zheng; Zheng, Longfei; Sun, Peng; Ding, Aijun

2017-11-01

Both anthropogenic emission and synoptic conditions play important roles in ozone (O3) formation and accumulation. In order to understand the influence of synoptic condition and holiday effects on ozone production in the Yangtze River Delta region, China, concentrations of speciated volatile organic compounds (VOCs) and O3 as well as other relevant trace gases were simultaneously measured at the Station for Observing Regional Processes of the Earth System (SORPES) in Nanjing around the National Day holidays of China in 2014, which featured substantial change of emissions and dominated by typical anti-cyclones. Different groups of VOC species and their chemical reactivities were comprehensively analyzed. We observed clear diurnal variations of short alkenes during the measurement period, considerable amount of short alkenes were observed during night (more than 10 ppb) while almost no alkenes were measured during daytime, which might be attributed to different chemical processes. The obvious enhancement of the VOC tracers during the National Day holidays (Oct. 1st-Oct. 7th) indicated that the holiday effect strongly influenced the distribution of VOC profile and chemical reactivity in the atmosphere. At the same time, two meso-scale anticyclone processes were also observed during the measurement period. The synoptic condition contributed to the accumulation of VOCs and other precursors, which consequently impacted the ozone production in this region. The integrated influence of synoptic and holiday effects was also analyzed with an Observation Based Model (OBM) based on simplified MCM (Master Chemical Mechanism) chemical mechanism. The calculated relative increment reactivity (RIR) of different VOC groups revealed that during the holidays, this region was in VOC-limited regime and the variation of RIR shows a close linkage to the development and elimination of anti-cyclones, indicating an in-negligible contribution of synoptic effect toward ozone production in this region.

Patterns of effective connectivity during memory encoding and retrieval differ between patients with mild cognitive impairment and healthy older adults.

PubMed

Hampstead, B M; Khoshnoodi, M; Yan, W; Deshpande, G; Sathian, K

2016-01-01

Previous research has shown that there is considerable overlap in the neural networks mediating successful memory encoding and retrieval. However, little is known about how the relevant human brain regions interact during these distinct phases of memory or how such interactions are affected by memory deficits that characterize mild cognitive impairment (MCI), a condition that often precedes dementia due to Alzheimer's disease. Here we employed multivariate Granger causality analysis using autoregressive modeling of inferred neuronal time series obtained by deconvolving the hemodynamic response function from measured blood oxygenation level-dependent (BOLD) time series data, in order to examine the effective connectivity between brain regions during successful encoding and/or retrieval of object location associations in MCI patients and comparable healthy older adults. During encoding, healthy older adults demonstrated a left hemisphere dominant pattern where the inferior frontal junction, anterior intraparietal sulcus (likely involving the parietal eye fields), and posterior cingulate cortex drove activation in most left hemisphere regions and virtually every right hemisphere region tested. These regions are part of a frontoparietal network that mediates top-down cognitive control and is implicated in successful memory formation. In contrast, in the MCI patients, the right frontal eye field drove activation in every left hemisphere region examined, suggesting reliance on more basic visual search processes. Retrieval in the healthy older adults was primarily driven by the right hippocampus with lesser contributions of the right anterior thalamic nuclei and right inferior frontal sulcus, consistent with theoretical models holding the hippocampus as critical for the successful retrieval of memories. The pattern differed in MCI patients, in whom the right inferior frontal junction and right anterior thalamus drove successful memory retrieval, reflecting the characteristic hippocampal dysfunction of these patients. These findings demonstrate that neural network interactions differ markedly between MCI patients and healthy older adults. Future efforts will investigate the impact of cognitive rehabilitation of memory on these connectivity patterns. Published by Elsevier Inc.

A combination of process of care and clinical target among type 2 diabetes mellitus patients in general medical clinics and specialist diabetes clinics at hospital levels.

PubMed

Sieng, Sokha; Hurst, Cameron

2017-08-07

This study compares a combination of processes of care and clinical targets among patients with type 2 diabetes mellitus (T2DM) between specialist diabetes clinics (SDCs) and general medical clinics (GMCs), and how differences between these two types of clinics differ with hospital type (community, provincial and regional). Type 2 diabetes mellitus patient medical records were collected from 595 hospitals (499 community, 70 provincial, 26 regional) in Thailand between April 1 to June 30, 2012 resulting in a cross-sectional sample of 26,860 patients. Generalized linear mixed modeling was conducted to examine associations between clinic type and quality of care. The outcome variables of interest were split into clinical targets and process of care. A subsequent subgroup analysis was conducted to examine if the nature of clinical target and process of care differences between GMCs and SDCs varied with hospital type (regional, provincial, community). Regardless of the types of hospitals (regional, provincial, or community) patients attending SDCs were considerably more likely to have eye and foot exam. In terms of larger hospitals (regional and provincial) patients attending SDCs were more likely to achieve HbA1c exam, All FACE exam, BP target, and the Num7Q. Interestingly, SDCs performed better than GMCs at only provincial hospitals for LDL-C target and the All7Q. Finally, patients with T2DM who attended community hospital-GMCs had a better chance of achieving the blood pressure target than patients who attended community hospital-SDCs. Specialized diabetes clinics outperform general medical clinics for both regional and provincial hospitals for all quality of care indicators and the number of quality of care indicators achieved was never lower. However, this better performance of SDC was not observed in community hospital. Indeed, GMCs outperformed SDCs for some quality of care indicators in the community level setting.

Sex-biased gene flow in spectacled eiders (Anatidae): Inferences from molecular markers with contrasting modes of inheritance

USGS Publications Warehouse

Scribner, Kim T.; Petersen, Margaret R.; Fields, Raymond L.; Talbot, Sandra L.; Pearce, John M.; Chesser, Ronald K.

2001-01-01

Genetic markers that differ in mode of inheritance and rate of evolution (a sex-linked Z-specific microsatellite locus, five biparentally inherited microsatellite loci, and maternally inherited mitochondrial [mtDNA] sequences) were used to evaluate the degree of spatial genetic structuring at macro- and microgeographic scales, among breeding regions and local nesting populations within each region, respectively, for a migratory sea duck species, the spectacled eider (Somateria fisheri). Disjunct and declining breeding populations coupled with sex-specific differences in seasonal migratory patterns and life history provide a series of hypotheses regarding rates and directionality of gene flow among breeding populations from the Indigirka River Delta, Russia, and the North Slope and Yukon-Kuskokwim Delta, Alaska. The degree of differentiation in mtDNA haplotype frequency among breeding regions and populations within regions was high (ϕCT = 0.189, P < 0.01; ϕSC = 0.059, P < 0.01, respectively). Eleven of 17 mtDNA haplotypes were restricted to a single breeding region. Genetic differences among regions were considerably lower for nuclear DNA loci (sex-linked: ϕST = 0.001, P > 0.05; biparentally inherited microsatellites: mean θ = 0.001, P > 0.05) than was observed for mtDNA. Using models explicitly designed for uniparental and biparentally inherited genes, estimates of spatial divergence based on nuclear and mtDNA data together with elements of the species' breeding ecology were used to estimate effective population size and degree of male and female gene flow. Differences in the magnitude and spatial patterns of gene correlations for maternally inherited and nuclear genes revealed that females exhibit greater natal philopatry than do males. Estimates of generational female and male rates of gene flow among breeding regions differed markedly (3.67 × 10−4 and 1.28 × 10−2, respectively). Effective population size for mtDNA was estimated to be at least three times lower than that for biparental genes (30,671 and 101,528, respectively). Large disparities in population sizes among breeding areas greatly reduces the proportion of total genetic variance captured by dispersal, which may accelerate rates of inbreeding (i.e., promote higher coancestries) within populations due to nonrandom pairing of males with females from the same breeding population.

Clinical perspectives on pulmonary systemic and macromolecular delivery.

PubMed

Scheuch, Gerhard; Kohlhaeufl, Martin J; Brand, Peter; Siekmeier, Ruediger

2006-10-31

The large epithelial surface area, the high organ vascularization, the thin nature of the alveolar epithelium and the immense capacity for solute exchange are factors that led the lung to serve as an ideal administration route for the application of drugs for treatment of systemic disorders. However, the deposition behaviour of aerosol particles in the respiratory tract depends on a number of physical (e.g. properties of the particle), chemical (e.g. properties of the drug) and physiological (e.g. breathing pattern, pulmonary diseases) factors. If these are not considered, it will not be possible to deposit a reproducible and sufficient amount of drug in a predefined lung region by means of aerosol inhalation. The lack of consideration of such issues led to many problems in inhalation drug therapy for many years mainly because physiological background of aerosol inhalation was not fully understood. However, over the last 20 years, there has been considerable progress in aerosol research and in the understanding of the underlying mechanisms of particle inhalation and pulmonary particle deposition. As a consequence, an increasing number of studies have been performed for the lung administration of drugs using a variety of different inhalation techniques. This review describes the physical and in part some of the physiological requirements that need to be considered for the optimization of pulmonary drug delivery to target certain lung regions.

Genome-wide investigation of genetic changes during modern breeding of Brassica napus.

PubMed

Wang, Nian; Li, Feng; Chen, Biyun; Xu, Kun; Yan, Guixin; Qiao, Jiangwei; Li, Jun; Gao, Guizhen; Bancroft, Ian; Meng, Jingling; King, Graham J; Wu, Xiaoming

2014-08-01

Considerable genome variation had been incorporated within rapeseed breeding programs over past decades. In past decades, there have been substantial changes in phenotypic properties of rapeseed as a result of extensive breeding effort. Uncovering the underlying patterns of allelic variation in the context of genome organisation would provide knowledge to guide future genetic improvement. We assessed genome-wide genetic changes, including population structure, genetic relatedness, the extent of linkage disequilibrium, nucleotide diversity and genetic differentiation based on F ST outlier detection, for a panel of 472 Brassica napus inbred accessions using a 60 k Brassica Infinium® SNP array. We found genetic diversity varied in different sub-groups. Moreover, the genetic diversity increased from 1950 to 1980 and then remained at a similar level in China and Europe. We also found ~6-10 % genomic regions revealed high F ST values. Some QTLs previously associated with important agronomic traits overlapped with these regions. Overall, the B. napus C genome was found to have more high F ST signals than the A genome, and we concluded that the C genome may contribute more valuable alleles to generate elite traits. The results of this study indicate that considerable genome variation had been incorporated within rapeseed breeding programs over past decades. These results also contribute to understanding the impact of rapeseed improvement on available genome variation and the potential for dissecting complex agronomic traits.

The Impact of Temperatures on the Stability of Rocks Surrounding a Single Fracture

NASA Astrophysics Data System (ADS)

Zhang, Yan; Li, Ning; Dai, Jun

2018-05-01

Research on the influence of temperature and the accompanying stress on the stability of the rocks surrounding an underground tunnel has become ever more important. This paper constructs a geometric model of a single-fracture tunnel by combining a high-temperature underground tunnel as the object of study with an example that uses a high-temperature tunnel segment in the water diversion tunnel of a hydropower station in Xinjiang. Based on the relevant theoretical analysis, with the consideration of different working conditions, a numerical experimental analysis was conducted to determine the two-dimensional transient temperature field distribution of the tunnel rock mass by using a numerical analysis software. The experimental data was consistent with the measured data. The calculated results show the following: a. when the temperature difference is greater, the stress concentration is higher near the fracture of the surrounding rock; b. the degree of the stress concentration in the crack tip region is not positively correlated to the distance, and there is a sensitive region where the stress varies.

Raether-Meek criterion for prediction of electrodeless discharge inception on a dielectric surface in different gases

NASA Astrophysics Data System (ADS)

Chvyreva, A.; Pancheshnyi, S.; Christen, T.; Pemen, A. J. M.

2018-03-01

Electrodeless streamer inception on an epoxy surface under AC voltage stress was investigated for different gas compositions and pressures, with a focus on the pressure region below 1 bar. For this purpose, we used a set-up with cylindrical electrodes embedded out-of-axis in a cylindrical epoxy rod. Experiments were performed in N2, SF6, ambient air, Ar and CO2. The discharge inception voltage was measured, from which the critical value K of the ionization integral was reconstructed assuming a non-disturbed Laplacian field distribution. We have validated that for electropositive gases Ar an N2 the generally assumed value of K  =  10 is in good agreement with our measurements. For electronegative gases, however, the experimentally obtained values turned out to be considerably higher. We attribute this discrepancy mainly to the statistical time delay of the first electron; to increase the probability of discharge inception in a critical region, it was necessary to extend the critical area by means of applying an overvoltage to the system.

A New Visual Trap for Rhagoletis cerasi (L.) (Diptera: Tephritidae)

PubMed Central

Daniel, Claudia; Mathis, Samuel; Feichtinger, Georg

2014-01-01

The European cherry fruit fly, Rhagoletis cerasi (L.) (Diptera: Tephritidae), is the most important pest of sweet cherries in Europe. The aim of our experiments was to develop a new, cost-efficient, lead chromate-free and more eco-friendly trap for monitoring and mass trapping of R. cerasi. Five different-colored yellow panels and three different trap shapes were compared to a standard Rebell® amarillo trap in three experimental orchards in 2012. Trap color F, with a strong increase in reflectance at 500–550 nm and a secondary peak in the UV-region at 300–400 nm, captured significantly more flies than the standard Rebell® amarillo trap. Yellow traps with increased reflectance in the blue region (400–500 nm) were least attractive. Trap shape was of minor importance, as long as the object was three-dimensional and visible from all directions. Based on economic and practical considerations, a cylinder-shaped trap “UFA-Samen Kirschenfliegenfalle” was developed for commercial use and is currently under on-farm evaluation. PMID:26462825

COMPUTERIZED TRAINING OF CRYOSURGERY – A SYSTEM APPROACH

PubMed Central

Keelan, Robert; Yamakawa, Soji; Shimada, Kenji; Rabin, Yoed

2014-01-01

The objective of the current study is to provide the foundation for a computerized training platform for cryosurgery. Consistent with clinical practice, the training process targets the correlation of the frozen region contour with the target region shape, using medical imaging and accepted criteria for clinical success. The current study focuses on system design considerations, including a bioheat transfer model, simulation techniques, optimal cryoprobe layout strategy, and a simulation core framework. Two fundamentally different approaches were considered for the development of a cryosurgery simulator, based on a finite-elements (FE) commercial code (ANSYS) and a proprietary finite-difference (FD) code. Results of this study demonstrate that the FE simulator is superior in terms of geometric modeling, while the FD simulator is superior in terms of runtime. Benchmarking results further indicate that the FD simulator is superior in terms of usage of memory resources, pre-processing, parallel processing, and post-processing. It is envisioned that future integration of a human-interface module and clinical data into the proposed computer framework will make computerized training of cryosurgery a practical reality. PMID:23995400

Food consumption trends and drivers

PubMed Central

Kearney, John

2010-01-01

A picture of food consumption (availability) trends and projections to 2050, both globally and for different regions of the world, along with the drivers largely responsible for these observed consumption trends are the subject of this review. Throughout the world, major shifts in dietary patterns are occurring, even in the consumption of basic staples towards more diversified diets. Accompanying these changes in food consumption at a global and regional level have been considerable health consequences. Populations in those countries undergoing rapid transition are experiencing nutritional transition. The diverse nature of this transition may be the result of differences in socio-demographic factors and other consumer characteristics. Among other factors including urbanization and food industry marketing, the policies of trade liberalization over the past two decades have implications for health by virtue of being a factor in facilitating the ‘nutrition transition’ that is associated with rising rates of obesity and chronic diseases such as cardiovascular disease and cancer. Future food policies must consider both agricultural and health sectors, thereby enabling the development of coherent and sustainable policies that will ultimately benefit agriculture, human health and the environment. PMID:20713385

Numerical simulation of present day tectonic stress across the Indian subcontinent

NASA Astrophysics Data System (ADS)

Yadav, R.; Tiwari, V. M.

2018-04-01

In situ measurements of maximum horizontal stress (S Hmax) in the Indian subcontinent are limited and do not present regional trends of intraplate stress orientation. The observed orientations of S Hmax vary considerably and often differ from the plate velocity direction. We have simulated orientation and magnitude of S Hmax through finite element modeling incorporating heterogeneities in elastic property of the Indian continent and plain stress approximation to understand the variability of S Hmax. Four different scenarios are tested in simulation: (1) homogeneous plate with fixed plate boundary (2) homogeneous plate with boundary forces (3) heterogeneous plate with fixed boundary (4) heterogeneous plate with boundary forces. The estimated orientation and magnitude of S Hmax with a heterogeneous plate with boundary forces in the Himalayan region and an eastern plate boundary comprising the Indo-Burmese arc and Andaman subduction zone are consistent with measured maximum horizontal stress. This study suggests that plate boundary force varies along the northern Indian plate margin and also provides a constraint on the intraplate stress field in the Indian subcontinent.

10 CFR 960.3-2-1 - Site screening for potentially acceptable sites.

Code of Federal Regulations, 2011 CFR

2011-01-01

... that contain rock formations of suitable depth, thickness, and lateral extent and have structural... require diversity of geohydrologic settings and rock types and consideration of regionality, as specified... provisions for diversity of geohydrologic settings, diversity of rock types, and regionality (§§ 960.3-1-1...

Climate change in Asia and the Pacific: How can countries adapt?

USDA-ARS?s Scientific Manuscript database

The Asia Pacific (AP) region is more vulnerable to climate change risks than other regions, given its dependence on the natural resources and agricultural sector for economic development with densely populated coastal areas, weak institutions, and the poverty of a considerable proportion of its popu...

From Silicon Valley to Phoenix Industries

ERIC Educational Resources Information Center

Puukka, Jaana

2009-01-01

As university leaders have long argued, the contribution of higher education to national and regional economies is considerable. Although the importance of universities in their local economies is not usually contested, much more should and could be done to take full advantage of higher education in regional and city development. Why have the…

Assessments of Future Maize Yield Potential Changes in the Korean Peninsula Using Multiple Crop Models

NASA Astrophysics Data System (ADS)

Kim, S. H.; Lim, C. H.; Kim, J.; Lee, W. K.; Kafatos, M.

2016-12-01

The Korean Peninsula has unique agricultural environment due to the differences of political and socio-economical system between Republic of Korea (SK, hereafter) and Democratic Peoples' Republic of Korea (NK, hereafter). NK has been suffering lack of food supplies caused by natural disasters, land degradation and political failure. The neighboring developed country SK has better agricultural system but very low food self-sufficiency rate. Maize is an important crop in both countries since it is staple food for NK and SK is No. 2 maize importing country in the world after Japan. Therefore, evaluating maize yield potential (Yp) in the two distinct regions is essential to assess food security under climate change and variability. In this study, we utilized multiple process-based crop models, having ability of regional scale assessment, to evaluate maize Yp and assess the model uncertainties -EPIC, GEPIC, DSSAT, and APSIM model that has capability of regional scale expansion (apsimRegions). First we evaluated each crop model for 3 years from 2012 to 2014 using reanalysis data (RDAPS; Regional Data Assimilation and Prediction System produced by Korea Meteorological Agency) and observed yield data. Each model performances were compared over the different regions in the Korean Peninsula having different local climate characteristics. To quantify of the major influence of at each climate variables, we also conducted sensitivity test using 20 years of climatology in historical period from 1981 to 2000. Lastly, the multi-crop model ensemble analysis was performed for future period from 2031 to 2050. The required weather variables projected for mid-century were employed from COordinated Regional climate Downscaling EXperiment (CORDEX) East Asia. The high-resolution climate data were obtained from multiple regional climate models (RCM) driven by multiple climate scenarios projected from multiple global climate models (GCMs) in conjunction with multiple greenhouse gas concentration pathways. The results indicate that the projected Yp in the Korean peninsula is significantly changed comparing to the historical period and proper adaptation strategies such as optimized planting dates can considerably alleviate Yp decrease.

Distribution and ecology of whistling swans in the Chesapeake Bay region

USGS Publications Warehouse

Stewart, R.E.; Manning, J.H.

1958-01-01

The Whistling Swan, Olor columbianus, is of particular significance in the Chesapeake Bay region, since major wintering and transient populations occur here regularly, constituting in some years more than half the total population of the species. Some of these concentrations are so large that they attract many bird-watchers, who often travel long distances to see them. Whistling Swans are also of concern to the local shell-fish gatherers, who claim that depredations by these birds cause considerable damage to the supply of commercially valuable long ("soft-shelled") clams. During recent years, there has been an increasing demand from some sources for an open hunting season. It has been suggested that the swan populations may be of sufficient numerical size, to withstand a limited harvest. Because of these considerations, a special effort was made to obtain more information concerning the local distribution, numerical status and ecology of Whistling Swans throughout the Chesapeake Bay region.

How Much Global Burned Area Can Be Forecast on Seasonal Time Scales Using Sea Surface Temperatures?

NASA Technical Reports Server (NTRS)

Chen, Yang; Morton, Douglas C.; Andela, Niels; Giglio, Louis; Randerson, James T.

2016-01-01

Large-scale sea surface temperature (SST) patterns influence the interannual variability of burned area in many regions by means of climate controls on fuel continuity, amount, and moisture content. Some of the variability in burned area is predictable on seasonal timescales because fuel characteristics respond to the cumulative effects of climate prior to the onset of the fire season. Here we systematically evaluated the degree to which annual burned area from the Global Fire Emissions Database version 4 with small fires (GFED4s) can be predicted using SSTs from 14 different ocean regions. We found that about 48 of global burned area can be forecast with a correlation coefficient that is significant at a p < 0.01 level using a single ocean climate index (OCI) 3 or more months prior to the month of peak burning. Continental regions where burned area had a higher degree of predictability included equatorial Asia, where 92% of the burned area exceeded the correlation threshold, and Central America, where 86% of the burned area exceeded this threshold. Pacific Ocean indices describing the El Nino-Southern Oscillation were more important than indices from other ocean basins, accounting for about 1/3 of the total predictable global burned area. A model that combined two indices from different oceans considerably improved model performance, suggesting that fires in many regions respond to forcing from more than one ocean basin. Using OCI-burned area relationships and a clustering algorithm, we identified 12 hotspot regions in which fires had a consistent response to SST patterns. Annual burned area in these regions can be predicted with moderate confidence levels, suggesting operational forecasts may be possible with the aim of improving ecosystem management.

Insight into the Peopling of Mainland Southeast Asia from Thai Population Genetic Structure

PubMed Central

Chaichoompu, Kridsadakorn; Ngamphiw, Chumpol; Assawamakin, Anunchai; Nuinoon, Manit; Sripichai, Orapan; Svasti, Saovaros; Fucharoen, Suthat; Praphanphoj, Verayuth; Tongsima, Sissades

2013-01-01

There is considerable ethno-linguistic and genetic variation among human populations in Asia, although tracing the origins of this diversity is complicated by migration events. Thailand is at the center of Mainland Southeast Asia (MSEA), a region within Asia that has not been extensively studied. Genetic substructure may exist in the Thai population, since waves of migration from southern China throughout its recent history may have contributed to substantial gene flow. Autosomal SNP data were collated for 438,503 markers from 992 Thai individuals. Using the available self-reported regional origin, four Thai subpopulations genetically distinct from each other and from other Asian populations were resolved by Neighbor-Joining analysis using a 41,569 marker subset. Using an independent Principal Components-based unsupervised clustering approach, four major MSEA subpopulations were resolved in which regional bias was apparent. A major ancestry component was common to these MSEA subpopulations and distinguishes them from other Asian subpopulations. On the other hand, these MSEA subpopulations were admixed with other ancestries, in particular one shared with Chinese. Subpopulation clustering using only Thai individuals and the complete marker set resolved four subpopulations, which are distributed differently across Thailand. A Sino-Thai subpopulation was concentrated in the Central region of Thailand, although this constituted a minority in an otherwise diverse region. Among the most highly differentiated markers which distinguish the Thai subpopulations, several map to regions known to affect phenotypic traits such as skin pigmentation and susceptibility to common diseases. The subpopulation patterns elucidated have important implications for evolutionary and medical genetics. The subpopulation structure within Thailand may reflect the contributions of different migrants throughout the history of MSEA. The information will also be important for genetic association studies to account for population-structure confounding effects. PMID:24223962

Impacts of uncertainties in European gridded precipitation observations on regional climate analysis

PubMed Central

Gobiet, Andreas

2016-01-01

ABSTRACT Gridded precipitation data sets are frequently used to evaluate climate models or to remove model output biases. Although precipitation data are error prone due to the high spatio‐temporal variability of precipitation and due to considerable measurement errors, relatively few attempts have been made to account for observational uncertainty in model evaluation or in bias correction studies. In this study, we compare three types of European daily data sets featuring two Pan‐European data sets and a set that combines eight very high‐resolution station‐based regional data sets. Furthermore, we investigate seven widely used, larger scale global data sets. Our results demonstrate that the differences between these data sets have the same magnitude as precipitation errors found in regional climate models. Therefore, including observational uncertainties is essential for climate studies, climate model evaluation, and statistical post‐processing. Following our results, we suggest the following guidelines for regional precipitation assessments. (1) Include multiple observational data sets from different sources (e.g. station, satellite, reanalysis based) to estimate observational uncertainties. (2) Use data sets with high station densities to minimize the effect of precipitation undersampling (may induce about 60% error in data sparse regions). The information content of a gridded data set is mainly related to its underlying station density and not to its grid spacing. (3) Consider undercatch errors of up to 80% in high latitudes and mountainous regions. (4) Analyses of small‐scale features and extremes are especially uncertain in gridded data sets. For higher confidence, use climate‐mean and larger scale statistics. In conclusion, neglecting observational uncertainties potentially misguides climate model development and can severely affect the results of climate change impact assessments. PMID:28111497

Impacts of uncertainties in European gridded precipitation observations on regional climate analysis.

PubMed

Prein, Andreas F; Gobiet, Andreas

2017-01-01

Gridded precipitation data sets are frequently used to evaluate climate models or to remove model output biases. Although precipitation data are error prone due to the high spatio-temporal variability of precipitation and due to considerable measurement errors, relatively few attempts have been made to account for observational uncertainty in model evaluation or in bias correction studies. In this study, we compare three types of European daily data sets featuring two Pan-European data sets and a set that combines eight very high-resolution station-based regional data sets. Furthermore, we investigate seven widely used, larger scale global data sets. Our results demonstrate that the differences between these data sets have the same magnitude as precipitation errors found in regional climate models. Therefore, including observational uncertainties is essential for climate studies, climate model evaluation, and statistical post-processing. Following our results, we suggest the following guidelines for regional precipitation assessments. (1) Include multiple observational data sets from different sources (e.g. station, satellite, reanalysis based) to estimate observational uncertainties. (2) Use data sets with high station densities to minimize the effect of precipitation undersampling (may induce about 60% error in data sparse regions). The information content of a gridded data set is mainly related to its underlying station density and not to its grid spacing. (3) Consider undercatch errors of up to 80% in high latitudes and mountainous regions. (4) Analyses of small-scale features and extremes are especially uncertain in gridded data sets. For higher confidence, use climate-mean and larger scale statistics. In conclusion, neglecting observational uncertainties potentially misguides climate model development and can severely affect the results of climate change impact assessments.

Cross - Scale Intercomparison of Climate Change Impacts Simulated by Regional and Global Hydrological Models in Eleven Large River Basins

NASA Technical Reports Server (NTRS)

Hattermann, F. F.; Krysanova, V.; Gosling, S. N.; Dankers, R.; Daggupati, P.; Donnelly, C.; Florke, M.; Huang, S.; Motovilov, Y.; Buda, S.;

Cross-scale intercomparison of climate change impacts simulated by regional and global hydrological models in eleven large river basins

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hattermann, F. F.; Krysanova, V.; Gosling, S. N.

Ideally, the results from models operating at different scales should agree in trend direction and magnitude of impacts under climate change. However, this implies that the sensitivity of impact models designed for either scale to climate variability and change is comparable. In this study, we compare hydrological changes simulated by 9 global and 9 regional hydrological models (HM) for 11 large river basins in all continents under reference and scenario conditions. The foci are on model validation runs, sensitivity of annual discharge to climate variability in the reference period, and sensitivity of the long-term average monthly seasonal dynamics to climatemore » change. One major result is that the global models, mostly not calibrated against observations, often show a considerable bias in mean monthly discharge, whereas regional models show a much better reproduction of reference conditions. However, the sensitivity of two HM ensembles to climate variability is in general similar. The simulated climate change impacts in terms of long-term average monthly dynamics evaluated for HM ensemble medians and spreads show that the medians are to a certain extent comparable in some cases with distinct differences in others, and the spreads related to global models are mostly notably larger. Summarizing, this implies that global HMs are useful tools when looking at large-scale impacts of climate change and variability, but whenever impacts for a specific river basin or region are of interest, e.g. for complex water management applications, the regional-scale models validated against observed discharge should be used.« less

Implications for local and global climate of alternative forest management strategies in Norway

NASA Astrophysics Data System (ADS)

Bright, Ryan M.; Antón-Fernández, Clara; Astrup, Rasmus; Cherubini, Francesco; Kvalevåg, Maria; Hammer Strømman, Anders

2014-05-01

We applied a mix of observation and empirical models to evaluate both local and global climate effects of three realistic alternative forest management scenarios in the boreal forests of Norway's largest logging region. The alternative management scenarios embraced strategies aimed at increasing harvest intensities and allowing harvested conifer sites to regenerate naturally with broadleaved species. Stand-level analysis was firstly executed to attribute differences in daily, seasonal, and annual mean surface temperatures to differences in surface intrinsic biophysical properties across coniferous, deciduous, and clear-cut sites. Relative to a coniferous site, we observed a slight local cooling of 0.13 °C at a deciduous site and 0.25 °C at a clear-cut site over a 6-year period which was mostly attributed to a higher albedo throughout the year. When monthly mean albedo trajectories over the entire managed forest landscape were taken into consideration, we found that strategies promoting natural regeneration of coniferous sites with native deciduous species led to substantial global direct climate cooling benefits relative to those maintaining current silviculture regimes - despite predicted long-term regional warming feedbacks and a reduced albedo in spring and autumn months. The magnitude and duration of the cooling benefit depended largely on whether management strategies simultaneously promoted an enhanced material supply over business-as-usual levels. While additional climate impact linked to changes in life-cycle emissions and to changes in the global supply and demand of timber products ought to be factored into any mitigation-oriented climate policy involving the forestry sector, our analysis demonstrates that - within the boundaries of the managed forest ecosystem - excluding important biogeophysical considerations like surface albedo change may lead to sub-optimal climate policy.

Characterization Urban Heat Island Effect and Modelling of Secondary Pollutant Formations at Urban Hotspots

NASA Astrophysics Data System (ADS)

Undi, G. S. N. V. K. S. N. S.

2017-12-01

More than 60 percent of the world population is living the urban zones by 2020. This socio of economic transformations will bring considerable changes to the ambient atmosphere. More than 70 percent of the air pollutants in the urban hotspots are from vehicular emissions. in the urban hotspots. In the urban hotspots, the meteorological and dispersion conditions will have different characteristics than in surrounding rural areas. Reactive pollutants transformations are drastically influenced by the local meteorological conditions. The complexity of urban structure alters the pollutants dispersion in the hotspots. This relationship between urban meteorology and air pollution is an important aspect of consideration. In the atmosphere, drastic changes have been noticed from micro to regional and global scales. However, the characteristics of air pollutant emissions vary with time and space, favorable dispersion conditions transport them from local to regional scale. In the present study, the impact of land cover change on Urban Heat Island effect (UHI) has been characterized by considering the three different zones with varying land use patterns. An attempt has been made to estimate the impact of UHI on secondary pollutants (O3) transformations. Envi-Met model has been used to characterize the UHI intensity for the selected zones. Meteorological and air quality measurements were carried out at the selected locations. The diurnal variations of Ozone (O3) concentration for three zones are correlated with the UHI intensity. And the monitoring and model results of O3 concentrations are in good agreement. It is observed from the obtained model results that the metrological parameters influence on local air quality is significant in urban zones.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stancanello, Joseph; Cavedon, Carlo; Francescon, Paolo

Functional magnetic resonance imaging (fMRI) is used to distinguish areas of the brain responsible for different tasks and functions. It is possible, for example, by using fMRI images, to identify particular regions in the brain which can be considered as 'functional organs at risk' (fOARs), i.e., regions which would cause significant patient morbidity if compromised. The aim of this study is to propose and validate a method to exploit functional information for the identification of fOARs in CyberKnife (Accuray, Inc., Sunnyvale, CA) radiosurgery treatment planning; in particular, given the high spatial accuracy offered by the CyberKnife system, local nonrigid registrationmore » is used to reach accurate image matching. Five patients affected by arteriovenous malformations (AVMs) and scheduled to undergo radiosurgery were scanned prior to treatment using computed tomography (CT), three-dimensional (3D) rotational angiography (3DRA), T2 weighted and blood oxygenation level dependent echo planar imaging MRI. Tasks were chosen on the basis of lesion location by considering those areas which could be potentially close to treatment targets. Functional data were superimposed on 3DRA and CT used for treatment planning. The procedure for the localization of fMRI areas was validated by direct cortical stimulation on 38 AVM and tumor patients undergoing conventional surgery. Treatment plans studied with and without considering fOARs were significantly different, in particular with respect to both maximum dose and dose volume histograms; consideration of the fOARs allowed quality indices of treatment plans to remain almost constant or to improve in four out of five cases compared to plans with no consideration of fOARs. In conclusion, the presented method provides an accurate tool for the integration of functional information into AVM radiosurgery, which might help to minimize undesirable side effects and to make radiosurgery less invasive.« less

An analysis of suicide and undetermined deaths in 17 predominantly Islamic countries contrasted with the UK.

PubMed

Pritchard, Colin; Amanullah, S

2007-03-01

Suicide is expressly condemned in the Qu'ran, and traditionally few Islamic countries have reported suicide. Undetermined deaths are classified by the World Health Organization (WHO) as Other Violent Deaths (OVD) in ICD-9, or Other External Causes (OEC) in ICD-10. It has been suggested that to avoid under-reporting of suicides, both formal suicide verdicts and OVD should be considered together because OVD may contain 'hidden' suicides. The latest WHO mortality data, by age and gender, were analysed and tested by chi2 tests. Levels of suicide and OVD in 17 Islamic countries were examined and contextually compared with UK rates. The regional Islamic cultural differences in Middle Eastern, South Asian, European Islam countries and those of the former Union of Socialist Soviet Republics (FUSSR) were analysed separately to test the hypotheses that there would be no difference between regional suicide and OVD rates per million (pm) and 17 Islamic countries and UK rates. Suicide rates were higher for males than females, and 'older' (65+) higher than 'younger' (15-34) rates in every country reviewed. The rate for Middle Eastern males was 0-36 pm, South Asian 0-12 pm, European 53-177 pm and FUSSR 30-506 pm, with three countries exceeding the UK rate of 116 pm. The Western male average OVD rate was 22 pm; the UK 55 pm rate was highest. Middle Eastern OVD was 1-420 pm, South Asian 0-166 pm, European 1-66 pm and FUSSR 11-361 pm. OVD rates in 10 Islamic countries were considerably higher than the Western average and eight had OVD rates considerably higher than their suicide rates. Islamic suicide rates varied widely and the high OVD rates, especially the Middle Eastern, may be a repository for hiding culturally unacceptable suicides.

Reduction of microbial contamination and improvement of germination of sweet basil (Ocimum basilicum L.) seeds via surface dielectric barrier discharge

NASA Astrophysics Data System (ADS)

Ambrico, Paolo F.; Šimek, Milan; Morano, Massimo; De Miccolis Angelini, Rita M.; Minafra, Angelantonio; Trotti, Pasquale; Ambrico, Marianna; Prukner, Václav; Faretra, Francesco

2017-08-01

Naturally contaminated basil seeds were treated by a surface dielectric barrier discharge driven in the humid air by an amplitude modulated AC high voltage to avoid heat shock. In order to avoid direct contact of seeds with microdischarge filaments, the seeds to be treated were placed at sufficient distance from the surface discharge. After treatment, the seeds were analyzed in comparison with control samples for their microbial contamination as well as for the capability of germination and seedling growth. Moreover, chemical modification of seed surface was observed through the elemental energy dispersive x-ray analysis and wettability tests. We found that treatment applied at 20% duty cycle (effective discharge duration up to 20 s) significantly decreases microbial load without reducing the viability of the seeds. On the other side, seedling growth was considerably accelerated after the treatment, and biometric growth parameters of seedlings (total length, weight, leaf extension) considerably increased compared to the controls. Interestingly, scanning electron microscopy images taken for the different duration of treatment revealed that seed radicle micropylar regions underwent significant morphological changes while the coat was substantially undamaged. Inside the seed, the embryo seemed to be well preserved while the endosperm body was detached from the epithelial tegument. A total of 9 different genera of fungi were recovered from the analyzed seeds. Scanning electron microscopy images revealed that conidia were localized especially in the micropylar region, and after plasma treatment, most of them showed substantial damages. Therefore, the overall effect of the treatment of naturally contaminated seeds by reactive oxygen and nitrogen species produced by plasma and the consequent changes in surface chemistry and microbial load can significantly improve seed vigor.

Lead and cadmium contamination of soil and vegetables in the Upper Silesia region of Poland.

PubMed

Gzyl, J

1990-07-01

Studies of the lead and cadmium content of soils and vegetables from 126 allotments in 12 towns in a polluted region of Poland are described. Metal concentrations in parsley, celery, carrots and red beet were determined using AAS. In most cases, metal concentrations in soils and vegetables exceeded accepted standards and concentrations found in rural regions. A total of 756 vegetable samples were studied and only 170 met the standard for lead and 17 for cadmium. The lowest lead content was found in parsley roots and the highest in celery leaves. Cadmium content between species did not differ greatly and the highest concentrations were recorded for celery. The metal intake by the consumer was also calculated using questionnaire data concerning vegetable consumption. In relation to the reference area, the metal intake in the polluted area was 2-5 times higher for lead and 2-16 times higher for cadmium. The main species responsible for the high metal concentrations were carrots and red beet. Replacing carrots and red beet with the same species grown in an unpolluted region would reduce the consumer's metal intake from vegetables considerably.

Eco-geographical differentiation among Colombian populations of the Chagas disease vector Triatoma dimidiata (Hemiptera: Reduviidae).

PubMed

Gómez-Palacio, Andrés; Triana, Omar; Jaramillo-O, Nicolás; Dotson, Ellen M; Marcet, Paula L

2013-12-01

Triatoma dimidiata is currently the main vector of Chagas disease in Mexico, most Central American countries and several zones of Ecuador and Colombia. Although this species has been the subject of several recent phylogeographic studies, the relationship among different populations within the species remains unclear. To elucidate the population genetic structure of T. dimidiata in Colombia, we analyzed individuals from distinct geographical locations using the cytochrome c oxidase subunit 1 gene and 7 microsatellite loci. A clear genetic differentiation was observed among specimens from three Colombian eco-geographical regions: Inter Andean Valleys, Caribbean Plains and Sierra Nevada de Santa Marta mountain (SNSM). Additionally, evidence of genetic subdivision was found within the Caribbean Plains region as well as moderate gene flow between the populations from the Caribbean Plains and SNSM regions. The genetic differentiation found among Colombian populations correlates, albeit weakly, with an isolation-by-distance model (IBD). The genetic heterogeneity among Colombian populations correlates with the eco-epidemiological and morphological traits observed in this species across regions within the country. Such genetic and epidemiological diversity should be taken into consideration for the development of vector control strategies and entomological surveillance. Copyright © 2013. Published by Elsevier B.V.

Eco-geographical differentiation among Colombian populations of the Chagas disease vector Triatoma dimidiata (Hemiptera: Reduviidae)

PubMed Central

Gómez-Palacio, Andrés; Triana, Omar; Jaramillo-O, Nicolás; Dotson, Ellen M.; Marcet, Paula L.

2016-01-01

Triatoma dimidiata is currently the main vector of Chagas disease in Mexico, most Central American countries and several zones of Ecuador and Colombia. Although this species has been the subject of several recent phylogeographic studies, the relationship among different populations within the species remains unclear. To elucidate the population genetic structure of T. dimidiata in Colombia, we analyzed individuals from distinct geographical locations using the cytochrome c oxidase subunit 1 gene and 7 microsatellite loci. A clear genetic differentiation was observed among specimens from three Colombian eco-geographical regions: Inter Andean Valleys, Caribbean Plains and Sierra Nevada de Santa Marta mountain (SNSM). Additionally, evidence of genetic subdivision was found within the Caribbean Plains region as well as moderate gene flow between the populations from the Caribbean Plains and SNSM regions. The genetic differentiation found among Colombian populations correlates, albeit weakly, with an isolation-by-distance model (IBD). The genetic heterogeneity among Colombian populations correlates with the eco-epidemiological and morphological traits observed in this species across regions within the country. Such genetic and epidemiological diversity should be taken into consideration for the development of vector control strategies and entomological surveillance. PMID:24035810

Analysis of the Relationship Between the Solar X-Ray Radiation Intensity and the D-Region Electron Density Using Satellite and Ground-Based Radio Data

NASA Astrophysics Data System (ADS)

Nina, Aleksandra; Čadež, Vladimir M.; Bajčetić, Jovan; Mitrović, Srdjan T.; Popović, Luka Č.

2018-04-01

Increases in the X-ray radiation that is emitted during a solar X-ray flare induce significant changes in the ionospheric D region. Because of the numerous complex processes in the ionosphere and the characteristics of the radiation and plasma, the causal-consequential relationship between the X-ray radiation and ionospheric parameters is not easily determined. In addition, modeling the ionospheric D-region plasma parameters is very difficult because of the lack of data for numerous time- and space-dependent physical quantities. In this article we first give a qualitative analysis of the relationship between the electron density and the recorded solar X-ray intensity. After this, we analyze the differences in the relationships between the D-region response and various X-ray radiation properties. The quantitative study is performed for data observed on 5 May 2010 in the time period between 11:40 UT - 12:40 UT when the GOES 14 satellite detected a considerable X-ray intensity increase. Modeling the electron density is based on characteristics of the 23.4 kHz signal emitted in Germany and recorded by the receiver in Serbia.

Child pneumonia - focus on the Western Pacific Region.

PubMed

Nguyen, T K P; Tran, T H; Roberts, C L; Graham, S M; Marais, B J

2017-01-01

Worldwide, pneumonia is the leading cause of death in infants and young children (aged <5 years). We provide an overview of the global pneumonia disease burden, as well as the aetiology and management practices in different parts of the world, with a specific focus on the WHO Western Pacific Region. In 2011, the Western Pacific region had an estimated 0.11 pneumonia episodes per child-year with 61,900 pneumonia-related deaths in children less than 5 years of age. The majority (>75%) of pneumonia deaths occurred in six countries; Cambodia, China, Laos, Papua New Guinea, the Philippines and Viet Nam. Historically Streptococcus pneumoniae and Haemophilus influenzae were the commonest causes of severe pneumonia and pneumonia-related deaths in young children, but this is changing with the introduction of highly effective conjugate vaccines and socio-economic development. The relative contribution of viruses and atypical bacteria appear to be increasing and traditional case management approaches may require revision to accommodate increased uptake of conjugated vaccines in the Western Pacific region. Careful consideration should be given to risk reduction strategies, enhanced vaccination coverage, improved management of hypoxaemia and antibiotic stewardship. Copyright © 2016 Elsevier Ltd. All rights reserved.

Quantifying regional consumption-based health impacts attributable to ambient air pollution in China.

PubMed

Zhang, Yanxia; Qu, Shen; Zhao, Jing; Zhu, Ge; Zhang, Yanxu; Lu, Xi; Sabel, Clive E; Wang, Haikun

2018-03-01

Serious air pollution has caused about one million premature deaths per year in China recently. Besides cross-border atmospheric transport of air pollution, trade also relocates pollution and related health impacts across China as a result of the spatial separation between consumption and production. This study proposes an approach for calculating the health impacts of emissions due to a region's consumption based on a multidisciplinary methodology coupling economic, atmospheric, and epidemiological models. These analyses were performed for China's Beijing and Hebei provinces. It was found that these provinces' consumption-based premature deaths attributable to ambient PM 2.5 were respectively 22,500 and 49,700, which were 23% higher and 37% lower than the numbers solely within their boundaries in 2007. The difference between the effects of trade and trade-related emissions on premature deaths attributable to air pollution in a region has also been clarified. The results illustrate the large and broad impact of domestic trade on regional air quality and the need for comprehensive consideration of supply chains in designing policy to mitigate the negative health impacts of air pollution across China. Copyright © 2017 Elsevier Ltd. All rights reserved.

All Rural Places Are Not Created Equal: Revisiting the Rural Mortality Penalty in the United States

PubMed Central

2014-01-01

Objectives. I investigated mortality disparities between urban and rural areas by measuring disparities in urban US areas compared with 6 rural classifications, ranging from suburban to remote locales. Methods. Data from the Compressed Mortality File, National Center for Health Statistics, from 1968 to 2007, was used to calculate age-adjusted mortality rates for all rural and urban regions by year. Criteria measuring disparity between regions included excess deaths, annual rate of change in mortality, and proportion of excess deaths by population size. I used multivariable analysis to test for differences in determinants across regions. Results. The rural mortality penalty existed in all rural classifications, but the degree of disparity varied considerably. Rural–urban continuum code 6 was highly disadvantaged, and rural–urban continuum code 9 displayed a favorable mortality profile. Population, socioeconomic, and health care determinants of mortality varied across regions. Conclusions. A 2-decade long trend in mortality disparities existed in all rural classifications, but the penalty was not distributed evenly. This constitutes an important public health problem. Research should target the slow rates of improvement in mortality in the rural United States as an area of concern. PMID:25211763

Impacts of heavy groundwater pumping on hydrogeological conditions in Libya: Past and present development and future prognosis on a regional scale

NASA Astrophysics Data System (ADS)

Elgzeli, Yousef M.; Ondovčin, Tomáš; Hrkal, Zbyněk; Krásný, Jiří; Mls, Jiří

2013-06-01

Elgzeli, Y.M., Ondovčin, T., Hrkal, Z., Krasny, J. and Mls, J. 2011. Impacts of heavy groundwater pumping on hydrogeological conditions in Libya: Past and present development and future prognosis on a regional scale. Acta Geologica Polonica, 63 (2), 283-296. Warszawa. Libya, like many other regions with arid climates, suffers from inadequate water resources to cover all the needs of this rapidly developing country. Increasing amounts of water are needed to supply the population, as well as for agricultural irrigation and industrial use. As groundwater is the main water source in the country, it represents a natural resource of the highest economic and social importance. Conceptual and numerical models were implemented on a regional scale to show how the natural situation has changed following heavy groundwater abstraction during the last decades in the northwestern part of the country. The results of the numerical model indicated that the current zones of depression of the piezometric surface could have been caused by smaller withdrawn amounts than previously estimated. The differences in the assessed withdrawn groundwater volumes seem to be quite high and might have a considerable influence on the future possibilities of groundwater use in the study region.

Oils and hydrocarbon source rocks of the Baltic syneclise

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kanev, S.; Margulis, L.; Bojesen-Koefoed, J.A.

Prolific source rock horizons of varying thickness, having considerable areal extent, occur over the Baltic syneclise. These source sediments are rich and have excellent petroleum generation potential. Their state of thermal maturity varies form immature in the northeastern part of the syneclise to peak generation maturity in the southwestern part of the region-the main kitchen area. These maturity variations are manifest in petroleum composition in the region. Hence, mature oils occur in the Polish and Kaliningrad areas, immature oils in small accumulations in Latvian and central Lithuanian onshore areas, and intermediate oils in areas between these extremes. The oil accumulationsmore » probably result from pooling of petroleum generated from a number of different source rocks at varying levels of thermal maturity. Hence, no single source for petroleum occurrences in the Baltic syneclise may be identified. The paper describes the baltic syneclise, source rocks, thermal maturity and oils and extracts.« less

Heterogeneity in Oligodendroglia: Is it Relevant to Mouse Models and Human Disease?

PubMed Central

Ornelas, Isis M.; McLane, Lauren E.; Saliu, Aminat; Evangelou, Angelina V.; Khandker, Luipa; Wood, Teresa L.

2016-01-01

There are many lines of evidence indicating that OPC and oligodendrocyte populations in the CNS are heterogeneous based on their developmental origins as well as from morphological and molecular criteria. Whether these distinctions reflect functional heterogeneity is less clear and has been the subject of considerable debate. Recent findings particularly from knockout mouse models have provided new evidence for regional variations in myelination phenotypes, particularly between brain and spinal cord. These data raise the possibility that oligodendrocytes in these regions have different functional capacities and/or ability to compensate for loss of a specific gene. The goal of this review is to briefly revisit the evidence for oligodendrocyte heterogeneity and then to present data from transgenic and demyelinating mouse models suggesting functional heterogeneity in myelination, demyelination and remyelination in the CNS and finally, to discuss the implications of these findings for human diseases. PMID:27557736

Electrical conductivity of aluminum hydride AlH3 at high pressure and temperature

NASA Astrophysics Data System (ADS)

Shakhray, Denis; Molodets, Alexander; Fortov, Vladimir; Khrapak, Aleksei

2009-06-01

A study of electrophysical and thermodynamic properties of alane AlH3 under multi shock compression has been carried out. The increase in specific electroconductivity of alane at shock compression up to pressure 100 GPa have been measured. High pressures and temperatures were obtained with explosive device, which accelerates the stainless impactor up to 3 km/sec. The impact shock is split into a shock wave reverberating in alane between two stiff metal anvils. The conductivity of shocked alane increases in the range up to 60-75 GPa and is about 30 1/Ohm*cm. In this region the semiconductor regime is true for shocked alane. The conductivity of alane achieves approximately 500 1/Ohm*cm at 80-90 GPa. In this region conductivity is interpreted in frames of the conception of the ``dielectric catastrophe'', taking into consideration significant difference between electronic states of isolated AlH3 molecule and condensed alane.

Isolated populations of the bush-cricket Pholidoptera frivaldszkyi (Orthoptera, Tettigoniidae) in Russia suggest a disjunct area of the species distribution

PubMed Central

Kaňuch, Peter; Dorková, Martina; Mikhailenko, Andrey P.; Polumordvinov, Oleg A.; Jarčuška, Benjamín; Krištín, Anton

2017-01-01

Abstract Phylogenetic analysis and assessment of the species status of mostly isolated populations of Pholidoptera frivaldszkyi in south-western Russia occurring far beyond the accepted area of the species distribution in the Carpathian-Balkan region were performed. Using the mitochondrial DNA cytochrome c oxidase subunit I gene fragment, we found a very low level of genetic diversity in these populations. Phylogeographic reconstruction did not support recent introduction events but rather historical range fragmentation. The grouping of the Russian and Romanian haplotypes in a distinct phylogenetic clade suggests that the pre-glacial range of P. frivaldszkyi had extended towards the Ponto-Caspian region, with considerable gene flow between different refugia. However, post-glacial northward expansion of the species from supposed Caucasus refugia contributed most likely to the current disjunct distribution of this relict-like bush-cricket. PMID:28769628

Isolated populations of the bush-cricket Pholidoptera frivaldszkyi (Orthoptera, Tettigoniidae) in Russia suggest a disjunct area of the species distribution.

PubMed

Kaňuch, Peter; Dorková, Martina; Mikhailenko, Andrey P; Polumordvinov, Oleg A; Jarčuška, Benjamín; Krištín, Anton

2017-01-01

Phylogenetic analysis and assessment of the species status of mostly isolated populations of Pholidoptera frivaldszkyi in south-western Russia occurring far beyond the accepted area of the species distribution in the Carpathian-Balkan region were performed. Using the mitochondrial DNA cytochrome c oxidase subunit I gene fragment, we found a very low level of genetic diversity in these populations. Phylogeographic reconstruction did not support recent introduction events but rather historical range fragmentation. The grouping of the Russian and Romanian haplotypes in a distinct phylogenetic clade suggests that the pre-glacial range of P. frivaldszkyi had extended towards the Ponto-Caspian region, with considerable gene flow between different refugia. However, post-glacial northward expansion of the species from supposed Caucasus refugia contributed most likely to the current disjunct distribution of this relict-like bush-cricket.

Causes and Solutions for High Energy Consumption in Traditional Buildings Located in Hot Climate Regions

NASA Astrophysics Data System (ADS)

Barayan, Olfat Mohammad

A considerable amount of money for high-energy consumption is spent in traditional buildings located in hot climate regions. High-energy consumption is significantly influenced by several causes, including building materials, orientation, mass, and openings' sizes. This paper aims to identify these causes and find practical solutions to reduce the annual cost of bills. For the purpose of this study, simulation research method has been followed. A comparison between two Revit models has also been created to point out the major cause of high-energy consumption. By analysing different orientations, wall insulation, and window glazing and applying some other high performance building techniques, a conclusion was found to confirm that appropriate building materials play a vital role in affecting energy cost. Therefore, the ability to reduce the energy cost by more than 50% in traditional buildings depends on a careful balance of building materials, mass, orientation, and type of window glazing.

Mitochondrial genomes of parasitic flatworms.

PubMed

Le, Thanh H; Blair, David; McManus, Donald P

2002-05-01

Complete or near-complete mitochondrial genomes are now available for 11 species or strains of parasitic flatworms belonging to the Trematoda and the Cestoda. The organization of these genomes is not strikingly different from those of other eumetazoans, although one gene (atp8) commonly found in other phyla is absent from flatworms. The gene order in most flatworms has similarities to those seen in higher protostomes such as annelids. However, the gene order has been drastically altered in Schistosoma mansoni, which obscures this possible relationship. Among the sequenced taxa, base composition varies considerably, creating potential difficulties for phylogeny reconstruction. Long non-coding regions are present in all taxa, but these vary in length from only a few hundred to approximately 10000 nucleotides. Among Schistosoma spp., the long non-coding regions are rich in repeats and length variation among individuals is known. Data from mitochondrial genomes are valuable for studies on species identification, phylogenies and biogeography.

Matrix-mediated synthesis of nanocrystalline gamma-Fe2O3 - A new optically transparent magnetic material

NASA Astrophysics Data System (ADS)

Ziolo, Ronald F.; Giannelis, Emmanuel P.; Weinstein, Bernard A.; O'Horo, Michael P.; Ganguly, Bishwanath N.; Mehrotra, Vivek; Russell, Michael W.; Huffman, Donald R.

1992-07-01

A magnetic material with appreciable optical transmission in the visible region at room temperature is isolated as a gamma-Fe2O3/polymer nanocomposite. The synthesis is carried out in an ion-exchange resin at 60 C. Magnetization and susceptibility data demonstrate loading-dependent saturation moments as high as 46 electromagnetic units per gram and superparamagnetism for lower loadings where particle sizes are less than 100 angstroms. Optical absorption studies show that the small-particle form of gamma-Fe2O3 is considerably more transparent to visible light than the single-crystal form. The difference in absorption ranges from nearly an order of magnitude in the 'red' spectral region to a factor of 3 at 5400 angstroms. The magnetization of the nanocomposite is greater by more than an order of magnitude than those of the strongest room-temperature transparent magnets, FeBO3 and FeF3.

Numerical Analysis of the Interaction between Thermo-Fluid Dynamics and Auto-Ignition Reaction in Spark Ignition Engines

NASA Astrophysics Data System (ADS)

Saijyo, Katsuya; Nishiwaki, Kazuie; Yoshihara, Yoshinobu

The CFD simulations were performed integrating the low-temperature oxidation reaction. Analyses were made with respect to the first auto-ignition location in the case of a premixed-charge compression auto-ignition in a laminar flow field and in the case of the auto-ignition in an end gas during an S. I. Engine combustion process. In the latter simulation, the spatially-filtered transport equations were solved to express fluctuating temperatures in a turbulent flow in consideration of strong non-linearity to temperature in the reaction equations. It is suggested that the first auto-ignition location does not always occur at higher-temperature locations and that the difference in the locations of the first auto-ignition depends on the time period during which the local end gas temperature passes through the region of shorter ignition delay, including the NTC region.

HIV Risk Behavior and Prevention Considerations Among Military Personnel in Three Caribbean Region Countries: Belize, Barbados, and the Dominican Republic.

PubMed

Asefnia, Nakisa; Cowan, Lisa; Werth, Rose

2017-01-01

We review research findings and the limitations of recent qualitative and quantitative studies of HIV prevalence and risk behaviors in military populations in three Caribbean countries (Dominican Republic, Belize, and Barbados). This research shows how mental health issues, disordered substance use, and structuring aspects of the occupational field produce and reproduce patterns of risk behaviors. We discuss the use of formative research, the Positive Health, Dignity, and Prevention framework, and the use of implementation science (including research methods that employ alternative methodological assumptions to better elucidate both cultural nuances and unknown components of program impact in different military populations) as a means to tailor individual prevention strategies to military populations. We conclude that greater adaption and ingenuity in prevention could improve behavioral prevention of HIV among military personnel in the Caribbean region. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

[Inventory of regional surface nutrient balance and policy recommendations in China].

PubMed

Chen, Min-Peng; Chen, Ji-Ning

2007-06-01

By applying OECD surface soil nitrogen balance methodology, the framework, methodology and database for nutrient balance budget in China are established to evaluate the impact of nutrient balance on agricultural production and water environment. Results show that nitrogen and phosphorus surplus in China are 640 x 10(4) t and 98 x 10(4) t respectively, and nitrogen and phosphorus surplus intensity in China are 16.56 kg/hm2 and 2.53 kg/hm2 respectively. Because of striking spatial difference of nutrient balance across the country, China is seeing a dual-challenge of nutrient surplus management as well as nutrient deficit management. Chemical fertilizer and livestock manure are best targets to perform nutrient surplus management due to their marked contributions to nutrient input. However, it is not cost-effective to implement a uniform management for all regions since nutrient input structures of them vary considerably.

Identifying Heat Waves in Florida: Considerations of Missing Weather Data

PubMed Central

Leary, Emily; Young, Linda J.; DuClos, Chris; Jordan, Melissa M.

2015-01-01

Background Using current climate models, regional-scale changes for Florida over the next 100 years are predicted to include warming over terrestrial areas and very likely increases in the number of high temperature extremes. No uniform definition of a heat wave exists. Most past research on heat waves has focused on evaluating the aftermath of known heat waves, with minimal consideration of missing exposure information. Objectives To identify and discuss methods of handling and imputing missing weather data and how those methods can affect identified periods of extreme heat in Florida. Methods In addition to ignoring missing data, temporal, spatial, and spatio-temporal models are described and utilized to impute missing historical weather data from 1973 to 2012 from 43 Florida weather monitors. Calculated thresholds are used to define periods of extreme heat across Florida. Results Modeling of missing data and imputing missing values can affect the identified periods of extreme heat, through the missing data itself or through the computed thresholds. The differences observed are related to the amount of missingness during June, July, and August, the warmest months of the warm season (April through September). Conclusions Missing data considerations are important when defining periods of extreme heat. Spatio-temporal methods are recommended for data imputation. A heat wave definition that incorporates information from all monitors is advised. PMID:26619198

Identifying Heat Waves in Florida: Considerations of Missing Weather Data.

PubMed

Leary, Emily; Young, Linda J; DuClos, Chris; Jordan, Melissa M

2015-01-01

Using current climate models, regional-scale changes for Florida over the next 100 years are predicted to include warming over terrestrial areas and very likely increases in the number of high temperature extremes. No uniform definition of a heat wave exists. Most past research on heat waves has focused on evaluating the aftermath of known heat waves, with minimal consideration of missing exposure information. To identify and discuss methods of handling and imputing missing weather data and how those methods can affect identified periods of extreme heat in Florida. In addition to ignoring missing data, temporal, spatial, and spatio-temporal models are described and utilized to impute missing historical weather data from 1973 to 2012 from 43 Florida weather monitors. Calculated thresholds are used to define periods of extreme heat across Florida. Modeling of missing data and imputing missing values can affect the identified periods of extreme heat, through the missing data itself or through the computed thresholds. The differences observed are related to the amount of missingness during June, July, and August, the warmest months of the warm season (April through September). Missing data considerations are important when defining periods of extreme heat. Spatio-temporal methods are recommended for data imputation. A heat wave definition that incorporates information from all monitors is advised.

Influence of land-atmosphere feedbacks on temperature and precipitation extremes in the GLACE-CMIP5 ensemble

NASA Astrophysics Data System (ADS)

Lorenz, Ruth; Argüeso, Daniel; Donat, Markus G.; Pitman, Andrew J.; van den Hurk, Bart; Berg, Alexis; Lawrence, David M.; Chéruy, Frédérique; Ducharne, Agnès.; Hagemann, Stefan; Meier, Arndt; Milly, P. C. D.; Seneviratne, Sonia I.

2016-01-01

We examine how soil moisture variability and trends affect the simulation of temperature and precipitation extremes in six global climate models using the experimental protocol of the Global Land-Atmosphere Coupling Experiment of the Coupled Model Intercomparison Project, Phase 5 (GLACE-CMIP5). This protocol enables separate examinations of the influences of soil moisture variability and trends on the intensity, frequency, and duration of climate extremes by the end of the 21st century under a business-as-usual (Representative Concentration Pathway 8.5) emission scenario. Removing soil moisture variability significantly reduces temperature extremes over most continental surfaces, while wet precipitation extremes are enhanced in the tropics. Projected drying trends in soil moisture lead to increases in intensity, frequency, and duration of temperature extremes by the end of the 21st century. Wet precipitation extremes are decreased in the tropics with soil moisture trends in the simulations, while dry extremes are enhanced in some regions, in particular the Mediterranean and Australia. However, the ensemble results mask considerable differences in the soil moisture trends simulated by the six climate models. We find that the large differences between the models in soil moisture trends, which are related to an unknown combination of differences in atmospheric forcing (precipitation, net radiation), flux partitioning at the land surface, and how soil moisture is parameterized, imply considerable uncertainty in future changes in climate extremes.

Genetic diversity among brazilian isolates of beauveria bassiana: comparisons with non-brazilian isolates and other beauveria species

USGS Publications Warehouse

Fernandes, E.K.K.; Moraes, A.M.L.; Pacheco, R.S.; Rangel, D.E.N.; Miller, M.P.; Bittencourt, V.R.E.P.; Roberts, D.W.

2009-01-01

Aims: The genetic diversity of Beauveria bassiana was investigated by comparing isolates of this species to each other (49 from different geographical regions of Brazil and 4 from USA) and to other Beauveria spp. Methods and Results: The isolates were examined by multilocus enzyme electrophoresis (MLEE), amplified fragment length polymorphism (AFLP), and rDNA sequencing. MLEE and AFLP revealed considerable genetic variability among B. bassiana isolates. Several isolates from South and Southeast Brazil had high similarity coefficients, providing evidence of at least one population with clonal structure. There were clear genomic differences between most Brazilian and USA B. bassiana isolates. A Mantel test using data generated by AFLP provided evidence that greater geographical distances were associated with higher genetic distances. AFLP and rDNA sequencing demonstrated notable genotypic variation between B. bassiana and other Beauveria spp. Conclusion: Geographical distance between populations apparently is an important factor influencing genotypic variability among B. bassiana populations in Brazil. Significance and Impact of the Study: This study characterized many B. bassiana isolates. The results indicate that certain Brazilian isolates are considerably different from others and possibly should be regarded as separate species from B. bassiana sensu latu. The information on genetic variation among the Brazilian isolates, therefore, will be important to comprehending the population structure of B. bassiana in Brazil. ?? 2009 The Society for Applied Microbiology.

The EuroPrevall birth cohort study on food allergy: baseline characteristics of 12,000 newborns and their families from nine European countries.

PubMed

McBride, D; Keil, T; Grabenhenrich, L; Dubakiene, R; Drasutiene, G; Fiocchi, A; Dahdah, L; Sprikkelman, A B; Schoemaker, A A; Roberts, G; Grimshaw, K; Kowalski, M L; Stanczyk-Przyluska, A; Sigurdardottir, S; Clausen, M; Papadopoulos, N G; Mitsias, D; Rosenfeld, L; Reche, M; Pascual, C; Reich, A; Hourihane, J; Wahn, U; Mills, E N C; Mackie, A; Beyer, K

2012-05-01

It is unclear why some children develop food allergy. The EuroPrevall birth cohort was established to examine regional differences in the prevalence and risk factors of food allergy in European children using gold-standard diagnostic criteria. The aim of this report was to describe pre-, post-natal and environmental characteristics among the participating countries. In nine countries across four major European climatic regions, mothers and their newborns were enrolled from October 2005 through February 2010. Using standardized questionnaires, we assessed allergic diseases and self-reported food hypersensitivity of parents and siblings, nutrition during pregnancy, nutritional supplements, medications, mode of delivery, socio-demographic data and home environmental exposures. A total of 12,049 babies and their families were recruited. Self-reported adverse reactions to food ever were considerably more common in mothers from Germany (30%), Iceland, United Kingdom, and the Netherlands (all 20-22%) compared with those from Italy (11%), Lithuania, Greece, Poland, and Spain (all 5-8%). Prevalence estimates of parental asthma, allergic rhinitis and eczema were highest in north-west (Iceland, UK), followed by west (Germany, the Netherlands), south (Greece, Italy, Spain) and lowest in central and east Europe (Poland, Lithuania). Over 17% of Spanish and Greek children were exposed to tobacco smoke in utero compared with only 8-11% in other countries. Caesarean section rate was highest in Greece (44%) and lowest in Spain (<3%). We found country-specific differences in antibiotic use, pet ownership, type of flooring and baby's mattress. In the EuroPrevall birth cohort study, the largest study using gold-standard diagnostic criteria for food allergy in children worldwide, we found considerable country-specific baseline differences regarding a wide range of factors that are hypothesized to play a role in the development of food allergy including allergic family history, obstetrical practices, pre- and post-natal environmental exposures. © 2011 John Wiley & Sons A/S.

The characteristics of electrical trees in the inner and outer layers of different voltage rating XLPE cable insulation

NASA Astrophysics Data System (ADS)

Xie, Ansheng; Li, Shengtao; Zheng, Xiaoquan; Chen, George

2009-06-01

The statistical initiation and propagation characteristics of electrical trees in cross-linked polyethylene (XLPE) cables with different voltage ratings from 66 to 500 kV were investigated under a constant test voltage of 50 Hz/7 kV (the 66 kV rating cable is from UK, the others from China). It was found that the characteristics of electrical trees in the inner region of 66 kV cable insulation differed considerably from those in the outer region under the same test conditions; however, no significant differences appeared in the 110 kV rating cable and above. The initiation time of electrical trees in both the inner and the outer regions of the 66 kV cable is much shorter than that in higher voltage rating cables; in addition the growth rate of electrical trees in the 66 kV cable is much larger than that in the higher voltage rating cables. By using x-ray diffraction, differential scanning calorimetry and thermogravimetry methods, it was revealed that besides the extrusion process, the molecular weight of base polymer material and its distribution are the prime factors deciding the crystallization state. The crystallization state and the impurity content are responsible for the resistance to electrical trees. Furthermore, it was proposed that big spherulites will cooperate with high impurity content in enhancing the initiation and growth processes of electrical trees via the 'synergetic effect'. Finally, dense and small spherulites, high crystallinity, high purity level of base polymer material and super-clean production processes are desirable for higher voltage rating cables.

[Control of anticoagulation in patients with non-valvular atrial fibrillation in a primary care clinical practice setting in the different autonomous communities. PAULA study].

PubMed

Polo García, J; Barrios Alonso, V; Escobar Cervantes, C; Prieto Valiente, L; Lobos Bejarano, J M; Vargas Ortega, D; Prieto Díaz, M Á; Alonso Moreno, F J; Barquilla García, A

2017-04-01

To determine the differences between regions in the level of control of patients with non-valvular atrial fibrillation treated with vitamin K antagonists, included in the PAULA study. Observational, and coss-sectional/retrospective study, including 139 Primary Care physicians from 99 Health Care centres in all autonomous communities (except La Rioja). Anticoagulation control was defined as the time in therapeutic range assessed by either the direct method (poor control <60%), or the Rosendaal method (poor control <65%). A total of 1,524 patients were included. Small differences in baseline characteristics of the patients were observed. Differences in the percentage of time in therapeutic range were observed, according to the Rosendaal method (mean 69.0±17.7%), from 78.1%±16.6 (Basque Country) to 61.5±14% (Balearic Islands), by the direct method (mean 63.2±17.9%) from 73.6%±16.6 (Basque Country) to 57.5±15.7% (Extremadura). When comparing regions, in those where the Primary Care physicians assumed full control without restrictions on prescription, the percentage of time in therapeutic range by the direct method was 63.89 vs. 60.95% in those with restrictions (p=.006), by Rosendaal method, 69.39% compared with 67.68% (p=.1036). There are significant differences in the level of control between some regions are still inadequate. Regions in which the Primary Care physicians assumed the management of anticoagulation and without restrictions, time in therapeutic range was somewhat higher, and showed a favourable trend for better control. These findings may have clinical implications, and deserve consideration and specific analysis. Copyright © 2016 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

Using canonical correlation analysis to identify environmental attitude groups: Considerations for national forest planning in the southwestern U.S

Treesearch

Alejandro J. Prera; Kristine M. Grimsrud; Jennifer A. Thacher; Dan W. McCollum; Robert P. Berrens

2014-01-01

As public land management agencies pursue region-specific resource management plans, with meaningful consideration of public attitudes and values, there is a need to characterize the complex mix of environmental attitudes in a diverse population. The contribution of this investigation is to make use of a unique household, mail/ internet survey data set collected in...

The New Compulsory Schooling Age Policy in NSW, Australia: Ethnicity, Ability and Gender Considerations

ERIC Educational Resources Information Center

Reid, Carol; Young, Helen

2012-01-01

The new schooling-leaving age policy in New South Wales, a state in Australia, requires all students to stay at school until they are 17 years old. The policy was introduced in January 2010, with little warning and, it appears, little consideration of its impact in complex contexts. In south-western Sydney, the most diverse region in the city, the…

Plan of Study for the Tidal Power Study, Cobscook Bay, Maine, USA

DTIC Science & Technology

1978-09-01

Considerations and Acceptability * Implementation Feasibility s Financial -Institutional Aspects * Public Health In preparing data for the System of Accounts ...Goals and Objectives a. National Objectives b. National Accounts c. Related National Policies d. The Study Objectives e. New England Federal Regional...Alternatives Development of Intermediate Plans 1. System of Accounts 2. Range of Alternatives to be considered 3. Other Evaluation Considerations 4

Status of hardwood forest resources in the Appalachian region including estimates of growth and removals

Treesearch

Christopher M. Oswalt; Jeffery A. Turner

2009-01-01

The Appalachian Hardwood Region (AHR) is an important wood producing area of the Eastern United States and is near a large portion of the U.S. population that is growing considerably. Combined, these two forces create the need for assessments of the hardwood forest resources in the region. Here we present results from an investigation into the forest resources of the...

Hazardous waste in the Asian Pacific region.

PubMed

Prasad, Rajendra; Khwaja, Mahmood A

2011-01-01

The production and disposal of hazardous waste remains a substantial problem in the Asian Pacific region. Remediation of waste disposal sites, including landfill sites, is attracting considerable research attention within the region. A recognition of the need for community engagement in this process is also growing. This article reviews the work presented in the Hazardous Waste sessions at the Pacific Basin Consortium for Environment and Health held in November 2009 in Perth.

Epidemiology of soil-transmitted helminthiases-related mortality in Brazil.

PubMed

Martins-Melo, Francisco R; Ramos, Alberto N; Alencar, Carlos H; Lima, Mauricélia S; Heukelbach, Jorg

2017-04-01

Soil-transmitted helminth (STH) infections are widely distributed in tropical and subtropical areas, including Brazil. We performed a nationwide population-based study including all deaths in Brazil from 2000 to 2011, in which STHs (ascariasis, trichuriasis and/or hookworm infection) were mentioned on death certificates, either as underlying or as associated causes of death. Epidemiological characteristics, time trends and spatial analysis of STH-related mortality were analysed. STHs was identified on 853/12 491 280 death certificates: 827 (97·0%) deaths related to ascariasis, 25 (2·9%) to hookworm infections, and 1 (0·1%) to trichuriasis. The average annual age-adjusted mortality rate was 0·34/1 000 000 inhabitants (95% confidence interval: 0·27-0·44). Females, children <10 years of age, indigenous ethnic groups and residents in the Northeast region had highest STH-related mortality rates. Nationwide mortality decreased significantly over time (annual percent change: -5·7%; 95% CI: -6·9 to -4·4), with regional differences. We identified spatial high-risk clusters for STH-related mortality mainly in the North, Northeast and South regions. Diseases of the digestive system and infectious/parasitic diseases were the most commonly associated causes of death mentioned in the STH-related deaths. Despite decreasing mortality in Brazil, a considerable number of deaths is caused by STHs, with ascariasis responsible for the vast majority. There were marked regional differences, affecting mainly children and vulnerable populations.

New Map Symbol System for Disaster Management

NASA Astrophysics Data System (ADS)

Marinova, Silvia T.

2018-05-01

In the last 10 years Bulgaria was frequently affected by natural and man-made disasters that caused considerable losses. According to the Bulgarian Disaster Management Act (2006) disaster management should be planned at local, regional and national level. Disaster protection is based on plans that include maps such as hazard maps, maps for protection, maps for evacuation planning, etc. Decision-making and cooperation between two or more neighboring municipalities or regions in crisis situation are still rendered difficult because the maps included in the plans differ in scale, colors, map symbols and cartographic design. To improve decision-making process in case of emergency and to reduce the number of human loss and property damages disaster management plans at local and regional level should be supported by detailed thematic maps created in accordance with uniform contents, map symbol system and design. The paper proposes a new symbol system for disaster management that includes a four level hierarchical classification of objects and phenomena according to their type and origin. All objects and phenomena of this classification are divided into five categories: disasters; infrastructure; protection services and infrastructure for protection; affected people and affected infrastructure; operational sites and activities. The symbols of these categories are shown with different background colors and shapes so that they are identifiable. All the symbols have simple but associative design. The new symbol system is used in the design of a series of maps for disaster management at local and regional level.

New chloroplast microsatellite markers suitable for assessing genetic diversity of Lolium perenne and other related grass species

PubMed Central

Diekmann, Kerstin; Hodkinson, Trevor R.; Barth, Susanne

2012-01-01

Background and Aims Lolium perenne (perennial ryegrass) is the most important forage grass species of temperate regions. We have previously released the chloroplast genome sequence of L. perenne ‘Cashel’. Here nine chloroplast microsatellite markers are published, which were designed based on knowledge about genetically variable regions within the L. perenne chloroplast genome. These markers were successfully used for characterizing the genetic diversity in Lolium and different grass species. Methods Chloroplast genomes of 14 Poaceae taxa were screened for mononucleotide microsatellite repeat regions and primers designed for their amplification from nine loci. The potential of these markers to assess genetic diversity was evaluated on a set of 16 Irish and 15 European L. perenne ecotypes, nine L. perenne cultivars, other Lolium taxa and other grass species. Key Results All analysed Poaceae chloroplast genomes contained more than 200 mononucleotide repeats (chloroplast simple sequence repeats, cpSSRs) of at least 7 bp in length, concentrated mainly in the large single copy region of the genome. Nucleotide composition varied considerably among subfamilies (with Pooideae biased towards poly A repeats). The nine new markers distinguish L. perenne from all non-Lolium taxa. TeaCpSSR28 was able to distinguish between all Lolium species and Lolium multiflorum due to an elongation of an A8 mononucleotide repeat in L. multiflorum. TeaCpSSR31 detected a considerable degree of microsatellite length variation and single nucleotide polymorphism. TeaCpSSR27 revealed variation within some L. perenne accessions due to a 44-bp indel and was hence readily detected by simple agarose gel electrophoresis. Smaller insertion/deletion events or single nucleotide polymorphisms detected by these new markers could be visualized by polyacrylamide gel electrophoresis or DNA sequencing, respectively. Conclusions The new markers are a valuable tool for plant breeding companies, seed testing agencies and the wider scientific community due to their ability to monitor genetic diversity within breeding pools, to trace maternal inheritance and to distinguish closely related species. PMID:22419761

New chloroplast microsatellite markers suitable for assessing genetic diversity of Lolium perenne and other related grass species.

PubMed

Diekmann, Kerstin; Hodkinson, Trevor R; Barth, Susanne

2012-11-01

Lolium perenne (perennial ryegrass) is the most important forage grass species of temperate regions. We have previously released the chloroplast genome sequence of L. perenne 'Cashel'. Here nine chloroplast microsatellite markers are published, which were designed based on knowledge about genetically variable regions within the L. perenne chloroplast genome. These markers were successfully used for characterizing the genetic diversity in Lolium and different grass species. Chloroplast genomes of 14 Poaceae taxa were screened for mononucleotide microsatellite repeat regions and primers designed for their amplification from nine loci. The potential of these markers to assess genetic diversity was evaluated on a set of 16 Irish and 15 European L. perenne ecotypes, nine L. perenne cultivars, other Lolium taxa and other grass species. All analysed Poaceae chloroplast genomes contained more than 200 mononucleotide repeats (chloroplast simple sequence repeats, cpSSRs) of at least 7 bp in length, concentrated mainly in the large single copy region of the genome. Nucleotide composition varied considerably among subfamilies (with Pooideae biased towards poly A repeats). The nine new markers distinguish L. perenne from all non-Lolium taxa. TeaCpSSR28 was able to distinguish between all Lolium species and Lolium multiflorum due to an elongation of an A(8) mononucleotide repeat in L. multiflorum. TeaCpSSR31 detected a considerable degree of microsatellite length variation and single nucleotide polymorphism. TeaCpSSR27 revealed variation within some L. perenne accessions due to a 44-bp indel and was hence readily detected by simple agarose gel electrophoresis. Smaller insertion/deletion events or single nucleotide polymorphisms detected by these new markers could be visualized by polyacrylamide gel electrophoresis or DNA sequencing, respectively. The new markers are a valuable tool for plant breeding companies, seed testing agencies and the wider scientific community due to their ability to monitor genetic diversity within breeding pools, to trace maternal inheritance and to distinguish closely related species.

The implication of irrigation in climate change impact assessment: a European-wide study.

PubMed

Zhao, Gang; Webber, Heidi; Hoffmann, Holger; Wolf, Joost; Siebert, Stefan; Ewert, Frank

2015-11-01

This study evaluates the impacts of projected climate change on irrigation requirements and yields of six crops (winter wheat, winter barley, rapeseed, grain maize, potato, and sugar beet) in Europe. Furthermore, the uncertainty deriving from consideration of irrigation, CO2 effects on crop growth and transpiration, and different climate change scenarios in climate change impact assessments is quantified. Net irrigation requirement (NIR) and yields of the six crops were simulated for a baseline (1982-2006) and three SRES scenarios (B1, B2 and A1B, 2040-2064) under rainfed and irrigated conditions, using a process-based crop model, SIMPLACE . We found that projected climate change decreased NIR of the three winter crops in northern Europe (up to 81 mm), but increased NIR of all the six crops in the Mediterranean regions (up to 182 mm yr(-1) ). Climate change increased yields of the three winter crops and sugar beet in middle and northern regions (up to 36%), but decreased their yields in Mediterranean countries (up to 81%). Consideration of CO2 effects can alter the direction of change in NIR for irrigated crops in the south and of yields for C3 crops in central and northern Europe. Constraining the model to rainfed conditions for spring crops led to a negative bias in simulating climate change impacts on yields (up to 44%), which was proportional to the irrigation ratio of the simulation unit. Impacts on NIR and yields were generally consistent across the three SRES scenarios for the majority of regions in Europe. We conclude that due to the magnitude of irrigation and CO2 effects, they should both be considered in the simulation of climate change impacts on crop production and water availability, particularly for crops and regions with a high proportion of irrigated crop area. © 2015 John Wiley & Sons Ltd.

A simple photometric factor in perceived depth order of bistable transparency patterns.

PubMed

Fukiage, Taiki; Oishi, Takeshi; Ikeuchi, Katsushi

2014-05-05

Previous studies on perceptual transparency defined the photometric condition in which perceived depth ordering between two surfaces becomes ambiguous. Even under this bistable transparency condition, it is known that depth-order perceptions are often biased toward one specific interpretation (Beck, Prazdny, & Ivry, 1984; Delogu, Fedorov, Belardinelli, & van Leeuwen, 2010; Kitaoka, 2005; Oyama & Nakahara, 1960). In this study, we examined what determines the perceived depth ordering for bistable transparency patterns using stimuli that simulated two partially overlapping disks resulting in four regions: a (background), b (portion of right disk), p (portion of left disk), and q (shared region). In contrast to the previous theory that proposed contributions of contrast against the background region (i.e., contrast at contour b/a and contrast at contour p/a) to perceived depth order in bistable transparency patterns, the present study demonstrated that contrast against the background region has little influence on perceived depth order compared with contrast against the shared region (i.e., contrast at contour b/q and contrast at contour p/q). In addition, we found that the perceived depth ordering is well predicted by a simpler model that takes into consideration only relative size of lightness difference against the shared region. Specifically, the probability that the left disk is perceived as being in front is proportional to (|b - q| - |p - q|) / (|b - q| + |p - q|) calculated based on lightness.

An analytical study of the minority carrier distribution and photocurrent of a p-i-n quantum dot solar cell based on the InAs/GaAs system

NASA Astrophysics Data System (ADS)

Biswas, Sayantan; Sinha, Amitabha

2017-10-01

An analytical study has been carried out on the InAs/GaAs p+-i-n+ quantum dot solar cell, taking into consideration the contributions of each region of the cell to the total photocurrent. The expressions for the excess minority carrier concentration and photocurrent from the front and the rear regions of the device have been obtained and their variations with different device parameters have been studied. Also, based on the investigations reported by some researchers earlier, the photocurrent contribution from the intrinsic region of the solar has been studied, taking into account the quantum dot ensemble absorption coefficient, which depends significantly on the quantum dot size and size dispersion. It is observed that all the three regions of the cell contribute to the overall internal quantum efficiency (IQE) of the cell. The contribution of each region of the solar cell to the total IQE has been shown graphically. From these studies it is observed that the incorporation of the quantum dots in the intrinsic region enhance the photocurrent density and hence the IQE of such solar cell, as it absorbs low energy photons, which are beyond the absorption range of GaAs. Finally, the fill factor of the solar cell has been calculated.

Sleep Duration and Overweight in European Children: Is the Association Modified by Geographic Region?

PubMed Central

Hense, Sabrina; Pohlabeln, Hermann; De Henauw, Stefaan; Eiben, Gabriele; Molnar, Dénes; Moreno, Luis A.; Barba, Gianvincenzo; Hadjigeorgiou, Charalampos; Veidebaum, Toomas; Ahrens, Wolfgang

2011-01-01

Study Objectives: To investigate differences and a possible effect modification by geographical region in the association between sleep duration and overweight. Design: Cross-sectional. Setting: Primary schools and preschools in 8 European countries. Participants: 7867 children aged 2 to 9 years. Interventions: Not applicable. Measurements: Nocturnal sleep duration was assessed as part of a parental 24-h recall. Height and weight were measured by standardized procedures across centers. Data on personal, social, environmental and behavioral factors were collected using a standardized parental questionnaire. Results: Sleep duration differed (P < 0.001) between European regions and normal vs. overweight children. A dose-dependent inverse association between sleep duration and overweight could be seen, with crude odds ratios ranging from 1.73 (99% CI 1.33; 2.25) for sleeping between 10 and 11 h to 3.81 (99% CI 2.85; 5.09) for sleeping less than 9 h (reference category > 11 h). This persisted after adjustment, but remained significant only for sleeping less than 9 h per night (north: OR = 1.70; 99% CI 1.13; 2.58 vs. south: OR = 2.84; 99% CI 1.57; 5.12) if stratified by region. No effect modification by region could be found, but adjustment for region accounted for changes in the effect estimate for sleeping less than 9 h (OR = 2.22; 99% CI 1.64; 3.02). The association was stronger in school children than in preschool children. Conclusion: Geographic region and related aspects—even if they do not seem to modify the association between sleep and overweight—should in any case be taken in consideration as a confounding factor on this association. Citation: Hense S; Pohlabeln H; De Henauw S; Eiben G; Molnar D; Moreno LA; Barba G; Hadjigeorgiou C; Veidebaum T; Ahrens W. Sleep duration and overweight in European children: is the association modified by geographic region? SLEEP 2011;34(7):885-890. PMID:21731138

Influence of aerosol-cloud interaction on austral summer precipitation over Southern Africa during ENSO events

NASA Astrophysics Data System (ADS)

Ruchith, R. D.; Sivakumar, V.

2018-04-01

In the present study, we are investigating the role of aerosols-and clouds in modulating the austral summer precipitation (December-February) during ENSO events over southern Africa region for the period from 2002 to2012 by using satellite and complimentary data sets. Aerosol radiative forcing (ARF) and Cloud radiative forcing (CRF) shows distinct patterns for El-Nina and La-Nina years. Further analysis were carried out by selecting the four Southern Africa regions where the precipitation shows remarkable difference during El-Nino and La-Nina years. These regions are R1 (33°S-24°S, 18°E-30°E), R2 (17°S-10°S, 24°E-32°E), R3 (19°S-9°S, 33°E-41°E) and R4 (7°S-0°S, 27°E-36°E). Aerosol Optical depth (AOD) shows considerable differences during these events. In region R1, R2 and R3 AOD shows more abundance in El-Nino years as compared to La-Nina years where as in R4 the AOD shows more abundance in La-Nina years. Cloud Droplet Effective radius (CDER) shows higher values during La-Nina years over R1, R2 and R3 regions but in R4 region CDER shows higher values in El-Nino years. Aerosol indirect effect (AIE) is estimated both for fixed cloud liquid water path (CLWP) and for fixed cloud ice path (CIP) bins, ranging from 1 to 300 gm -2 at 25 gm -2 interval over all the selected regions for El-Nino and La-Nina years. The results indicate more influence of positive indirect effect (Twomey effect) over R1 and R3 region during El-Nino years as compared to La-Nina years. This analysis reveals the important role of aerosol on cloud-precipitation interaction mechanism illustrating the interlinkage between dynamics and microphysics during austral summer season over southern Africa.

Aspect of ECMWF downscaled Regional Climate Modeling in simulating Indian summer monsoon rainfall and dependencies on lateral boundary conditions

NASA Astrophysics Data System (ADS)

Ghosh, Soumik; Bhatla, R.; Mall, R. K.; Srivastava, Prashant K.; Sahai, A. K.

2018-03-01

Climate model faces considerable difficulties in simulating the rainfall characteristics of southwest summer monsoon. In this study, the dynamical downscaling of European Centre for Medium-Range Weather Forecast's (ECMWF's) ERA-Interim (EIN15) has been utilized for the simulation of Indian summer monsoon (ISM) through the Regional Climate Model version 4.3 (RegCM-4.3) over the South Asia Co-Ordinated Regional Climate Downscaling EXperiment (CORDEX) domain. The complexities of model simulation over a particular terrain are generally influenced by factors such as complex topography, coastal boundary, and lack of unbiased initial and lateral boundary conditions. In order to overcome some of these limitations, the RegCM-4.3 is employed for simulating the rainfall characteristics over the complex topographical conditions. For reliable rainfall simulation, implementations of numerous lower boundary conditions are forced in the RegCM-4.3 with specific horizontal grid resolution of 50 km over South Asia CORDEX domain. The analysis is considered for 30 years of climatological simulation of rainfall, outgoing longwave radiation (OLR), mean sea level pressure (MSLP), and wind with different vertical levels over the specified region. The dependency of model simulation with the forcing of EIN15 initial and lateral boundary conditions is used to understand the impact of simulated rainfall characteristics during different phases of summer monsoon. The results obtained from this study are used to evaluate the activity of initial conditions of zonal wind circulation speed, which causes an increase in the uncertainty of regional model output over the region under investigation. Further, the results showed that the EIN15 zonal wind circulation lacks sufficient speed over the specified region in a particular time, which was carried forward by the RegCM output and leads to a disrupted regional simulation in the climate model.

HIV status of partners of HIV positive pregnant women in different regions of Nigeria: matters arising.

PubMed

Sagay, A S; Onakewhor, J; Galadanci, H; Emuveyan, E E

2006-12-01

This study was conducted to determine the pattern of HIV sero-status of Partners of HIV Positive Pregnant Women in three different regions of Nigeria and to explore the implications for HIV prevention interventions. The Site Coordinators of PMTCT programs in three Nigerian cities obtained data of the HIV status of the partners of HIV positive pregnant women. The selection of Benin City, Jos and Kano was made after consideration of their ethnic, religious and cultural representation of Nigeria. Benin City represents a traditional southern Nigeria city, Kano a traditional northern city and Jos, a middle-belt, ethnically diverse cosmopolitan setting. The data were analyzed using frequencies. A total of 500 partners of HIV infected pregnant women were tested for HIV using Determine Abbott test kits. Positive results were confirmed using Western blot or a second rapid test kit. The city-by-city results showed that in Benin City (Southern Nigeria), 78.8% (104/132) of the partners were HIV negative (sero-discordant), Jos (Middle-Belt) had 48.4% (103/213) sero-discordance while Kano (Northern Nigeria) recorded a sero-discordance rate of only 7.7% (12/155). These results indicate that the dynamics of HIV transmission in marital settings in Nigeria are different in the various regions of the country. Socio-cultural and religious settings play a significant role in HIV transmission among couples. These findings should guide prevention interventions in order to achieve maximal impact.

Reliability of shell carbon isotope composition of different land snail species as a climate proxy: A case study in the monsoon region of China

NASA Astrophysics Data System (ADS)

Bao, Rui; Sheng, Xuefen; Teng, Henry H.; Ji, Junfeng

2018-05-01

Carbon isotope compositions of land snail shells (δ13Cshell) are shown to be indicative of local climate conditions. However, it is largely unknown how the responses of δ13Cshell to climatic factors changes amongst different species. In this study, we collected 3 species of land snail shells across the East Asian monsoon region of China to explore the overall relationship between δ13Cshell as well as the response of individual species to the regional climate. Results show that, whereas all species collectively can provide a consensus relation between δ13Cshell and local climatic factors such as temperature and precipitation; the response of individual species to the fluctuations of these factors is not uniform. Specifically, while the southerly species Bradybaena similaris exhibits robust δ13Cshell - mean precipitation correlation in both linearity and sensitivity, a common northerly species, Cathaica fasciola, only finds limited utility as a climate indicator, particularly for precipitation. Meanwhile, the south-central species Acusta ravida appears to be able to faithfully record past climate conditions despite showing a wider distribution and a broader habitat. Such species-dependent nature in the relations between δ13Cshell and local climatic factors can be attributed to the effect of ingested carbonate and variations in eco-physiological factors of different species, and is expected to be widespread, suggesting the need to be taken into consideration for future studies.

Urban air pollution and health risks of parent and nitrated polycyclic aromatic hydrocarbons in two megacities, southwest China

NASA Astrophysics Data System (ADS)

Zhuo, Shaojie; Du, Wei; Shen, Guofeng; Wang, Rui; Pan, Xuelian; Li, Tongchao; Han, Yang; Li, Yungui; Pan, Bo; Peng, Xing; Cheng, Hefa; Wang, Xilong; Shi, Guoliang; Xing, Baoshan; Tao, Shu

2017-10-01

Ambient air pollution in China has a significant spatial variation due to the uneven development and different energy structures. This study characterized ambient pollution of parent and nitrated polycyclic aromatic hydrocarbons (PAHs) through a 1-year measurement in two megacities in southwest China where regional PM2.5 levels were considerably lower than other regions. Though the annual average BaP levels in both two cities were below the national standard of 1.0 ng/m3, however, by taking other PAHs into account, PAHs pollution were serious as indicated by high BaP equivalent concentrations (BaPEQ) of 3.8 ± 2.6 and 4.4 ± 1.9 ng/m3, respectively. Risk assessment would be underestimated by nearly an order of magnitude if only using BaP in risk assessment compared to the estimation based on 26 PAHs including 16 priority and 10 non-priority isomers targeted in this study. Estimated incremental lifetime cancer risks (ILCR) were comparable at two cities, at about 330-380 persons per one million, even though the mass concentrations were significantly different. Nitrated PAHs showed distinct temporal and site differences compared to the parent PAHs. High cancer risks due to inhalation exposure of PAHs and their polar derivatives in the low PM2.5-pollution southwest China suggest essential and effective controls on ambient PAHs pollution in the region, and controls should take potential health risks into account instead of solely mass concentration.

Regionalisation of Hydrological Indices to Assess Land-Use Change Impacts in the Tropical Andes

NASA Astrophysics Data System (ADS)

Buytaert, W.; Ochoa Tocachi, B. F.

2014-12-01

Andean ecosystems are major water sources for cities and communities located in the Tropical Andes; however, there is a considerable lack of knowledge about their hydrology. Two problems are especially important: (i) the lack of monitoring to assess the impacts of historical land-use and cover change and degradation (LUCCD) at catchment scale, and (ii) the high variability in climatic and hydrological conditions that complicate the evaluation of land management practices. This study analyses how a reliable LUCCD impacts assessment can be performed in an environment of high variability combined with data-scarcity and low-quality records. We use data from participatory hydrological monitoring activities in 20 catchments distributed along the tropical Andes. A set of 46 hydrological indices is calculated and regionalized by relating them to 42 physical catchment properties. Principal Component Analysis (PCA) is performed to maximise available data while minimising redundancy in the sets of variables. Hydrological model parameters are constrained by estimated indices, and different behavioural predictions are assembled to provide a generalised response on which we assess LUCCD impacts. Results from this methodology show that the attributed effects of LUCCD in pair-wise catchment comparisons may be overstated or hidden by different sources of uncertainty, including measurement inaccuracies and model structural errors. We propose extrapolation and evaluation in ungauged catchments as a way to regionalize LUCCD predictions and to provide statistically significant conclusions in the Andean region. These estimations may deliver reliable knowledge to evaluate the hydrological impact of different watershed management practices.

Severe Autumn storms in future Western Europe with a warmer Atlantic Ocean

NASA Astrophysics Data System (ADS)

Baatsen, Michiel; Haarsma, Reindert J.; Van Delden, Aarnout J.; de Vries, Hylke

2015-08-01

Simulations with a very high resolution (~25 km) global climate model indicate that more severe Autumn storms will impact Europe in a warmer future climate. The observed increase is mainly attributed to storms with a tropical origin, especially in the later part of the twentyfirst century. As their genesis region expands, tropical cyclones become more intense and their chances of reaching Europe increase. This paper investigates the properties and evolution of such storms and clarifies the future changes. The studied tropical cyclones feature a typical evolution of tropical development, extratropical transition and a re-intensification. A reduction of the transit area between regions of tropical and extratropical cyclogenesis increases the probability of re-intensification. Many of the modelled storms exhibit hybrid properties in a considerable part of their life cycle during which they exhibit the hazards of both tropical and extratropical systems. In addition to tropical cyclones, other systems such as cold core extratropical storms mainly originating over the Gulf Stream region also increasingly impact Western Europe. Despite their different history, all of the studied storms have one striking similarity: they form a warm seclusion. The structure, intensity and frequency of storms in the present climate are compared to observations using the MERRA and IBTrACS datasets. Damaging winds associated with the occurrence of a sting jet are observed in a large fraction of the cyclones during their final stage. Baroclinic instability is of great importance for the (re-)intensification of the storms. Furthermore, so-called atmospheric rivers providing tropical air prove to be vital for the intensification through diabatic heating and will increase considerably in strength in the future, as will the associated flooding risks.

Sensitivity analysis of seismic hazard for the northwestern portion of the state of Gujarat, India

USGS Publications Warehouse

Petersen, M.D.; Rastogi, B.K.; Schweig, E.S.; Harmsen, S.C.; Gomberg, J.S.

2004-01-01

We test the sensitivity of seismic hazard to three fault source models for the northwestern portion of Gujarat, India. The models incorporate different characteristic earthquake magnitudes on three faults with individual recurrence intervals of either 800 or 1600 years. These recurrence intervals imply that large earthquakes occur on one of these faults every 266-533 years, similar to the rate of historic large earthquakes in this region during the past two centuries and for earthquakes in intraplate environments like the New Madrid region in the central United States. If one assumes a recurrence interval of 800 years for large earthquakes on each of three local faults, the peak ground accelerations (PGA; horizontal) and 1-Hz spectral acceleration ground motions (5% damping) are greater than 1 g over a broad region for a 2% probability of exceedance in 50 years' hazard level. These probabilistic PGAs at this hazard level are similar to median deterministic ground motions. The PGAs for 10% in 50 years' hazard level are considerably lower, generally ranging between 0.2 g and 0.7 g across northwestern Gujarat. Ground motions calculated from our models that consider fault interevent times of 800 years are considerably higher than other published models even though they imply similar recurrence intervals. These higher ground motions are mainly caused by the application of intraplate attenuation relations, which account for less severe attenuation of seismic waves when compared to the crustal interplate relations used in these previous studies. For sites in Bhuj and Ahmedabad, magnitude (M) 7 3/4 earthquakes contribute most to the PGA and the 0.2- and 1-s spectral acceleration ground motion maps at the two considered hazard levels. ?? 2004 Elsevier B.V. All rights reserved.

Physically-Based Probabilistic Seismic Hazard Analysis Using Broad-Band Ground Motion Simulation: a Case Study for Prince Islands Fault, Marmara Sea

NASA Astrophysics Data System (ADS)

Mert, A.

2016-12-01

The main motivation of this study is the impending occurrence of a catastrophic earthquake along the Prince Island Fault (PIF) in Marmara Sea and the disaster risk around Marmara region, especially in İstanbul. This study provides the results of a physically-based Probabilistic Seismic Hazard Analysis (PSHA) methodology, using broad-band strong ground motion simulations, for sites within the Marmara region, Turkey, due to possible large earthquakes throughout the PIF segments in the Marmara Sea. The methodology is called physically-based because it depends on the physical processes of earthquake rupture and wave propagation to simulate earthquake ground motion time histories. We include the effects of all considerable magnitude earthquakes. To generate the high frequency (0.5-20 Hz) part of the broadband earthquake simulation, the real small magnitude earthquakes recorded by local seismic array are used as an Empirical Green's Functions (EGF). For the frequencies below 0.5 Hz the simulations are obtained using by Synthetic Green's Functions (SGF) which are synthetic seismograms calculated by an explicit 2D/3D elastic finite difference wave propagation routine. Using by a range of rupture scenarios for all considerable magnitude earthquakes throughout the PIF segments we provide a hazard calculation for frequencies 0.1-20 Hz. Physically based PSHA used here follows the same procedure of conventional PSHA except that conventional PSHA utilizes point sources or a series of point sources to represent earthquakes and this approach utilizes full rupture of earthquakes along faults. Further, conventional PSHA predicts ground-motion parameters using by empirical attenuation relationships, whereas this approach calculates synthetic seismograms for all magnitude earthquakes to obtain ground-motion parameters. PSHA results are produced for 2%, 10% and 50% hazards for all studied sites in Marmara Region.

[Tularaemia - a forgotten disease? Own experience].

PubMed

Yanushevych, Mariya; Komorowska-Piotrowska, Anna; Feleszko, Wojciech

2013-01-01

Tularaemia is an acute, animal-born disease, caused by Gram-negative aerobic bacilli - Francisella tularensis. Due to its high infectiousness and virulence it remains an epidemiological issue in some countries. The prevalence rate of tularaemia in the Scandinavian region, where most of the cases among European countries have been reported, it has remained stable since 2006, whereas in Poland a small, but stable increase has been observed. The first case of tularaemia in Poland was diagnosed in 1949 and since then more than 600 cases have been reported, mainly in the north-eastern and north-western regions of the country. In the majority of cases the infection has been transmitted by ixode bites or through direct contact with infected animals. Depending on the route of transmission, tularaemia can develop in different forms with a characteristic sudden onset of high fever and local lymphadenopathy. In Europe 95% of cases account for the ulceroglandular type, which characteristically presents with skin ulceration and inflammation of regional tissues and lymph nodes. This is the reason why it should always be taken into consideration in differential diagnosis of lymphadenitis, especially if its course is atypical or it does not respond to antibiotic therapy. The above mentioned atypical course of the disease and resistance to empirical treatment contribute to the challenge encountered by physicians in the process of diagnosis and treatment. The aim of the study is to present the most important data on tularaemia as an animal-born, infectious disease and to convince physicians to take it into consideration in the differential diagnosis of ymphadenopathy. We illustrate this article with the case of ulceroglandular type of tularemia diagnosed in a 5 year-old boy and describe the encountered diagnostic and therapeutic problems.

Spatially explicit estimation of heat stress-related impacts of climate change on the milk production of dairy cows in the United Kingdom.

PubMed

Fodor, Nándor; Foskolos, Andreas; Topp, Cairistiona F E; Moorby, Jon M; Pásztor, László; Foyer, Christine H

2018-01-01

Dairy farming is one the most important sectors of United Kingdom (UK) agriculture. It faces major challenges due to climate change, which will have direct impacts on dairy cows as a result of heat stress. In the absence of adaptations, this could potentially lead to considerable milk loss. Using an 11-member climate projection ensemble, as well as an ensemble of 18 milk loss estimation methods, temporal changes in milk production of UK dairy cows were estimated for the 21st century at a 25 km resolution in a spatially-explicit way. While increases in UK temperatures are projected to lead to relatively low average annual milk losses, even for southern UK regions (<180 kg/cow), the 'hottest' 25×25 km grid cell in the hottest year in the 2090s, showed an annual milk loss exceeding 1300 kg/cow. This figure represents approximately 17% of the potential milk production of today's average cow. Despite the potential considerable inter-annual variability of annual milk loss, as well as the large differences between the climate projections, the variety of calculation methods is likely to introduce even greater uncertainty into milk loss estimations. To address this issue, a novel, more biologically-appropriate mechanism of estimating milk loss is proposed that provides more realistic future projections. We conclude that South West England is the region most vulnerable to climate change economically, because it is characterised by a high dairy herd density and therefore potentially high heat stress-related milk loss. In the absence of mitigation measures, estimated heat stress-related annual income loss for this region by the end of this century may reach £13.4M in average years and £33.8M in extreme years.