The comER Gene Plays an Important Role in Biofilm Formation and Sporulation in both Bacillus subtilis and Bacillus cereus.

PubMed

Yan, Fang; Yu, Yiyang; Wang, Luyao; Luo, Yuming; Guo, Jian-Hua; Chai, Yunrong

2016-01-01

Bacteria adopt alternative cell fates during development. In Bacillus subtilis, the transition from planktonic growth to biofilm formation and sporulation is controlled by a complex regulatory circuit, in which the most important event is activation of Spo0A, a transcription factor and a master regulator for genes involved in both biofilm formation and sporulation. In B. cereus, the regulatory pathway controlling biofilm formation and cell differentiation is much less clear. In this study, we show that a novel gene, comER, plays a significant role in biofilm formation as well as sporulation in both B. subtilis and B. cereus. Mutations in the comER gene result in defects in biofilm formation and a delay in spore formation in the two Bacillus species. Our evidence supports the idea that comER may be part of the regulatory circuit that controls Spo0A activation. comER likely acts upstream of sda, a gene encoding a small checkpoint protein for both sporulation and biofilm formation, by blocking the phosphor-relay and thereby Spo0A activation. In summary, our studies outlined a conserved, positive role for comER, a gene whose function was previously uncharacterized, in the regulation of biofilm formation and sporulation in the two Bacillus species.

The comER Gene Plays an Important Role in Biofilm Formation and Sporulation in both Bacillus subtilis and Bacillus cereus

PubMed Central

Yan, Fang; Yu, Yiyang; Wang, Luyao; Luo, Yuming; Guo, Jian-hua; Chai, Yunrong

2016-01-01

Bacteria adopt alternative cell fates during development. In Bacillus subtilis, the transition from planktonic growth to biofilm formation and sporulation is controlled by a complex regulatory circuit, in which the most important event is activation of Spo0A, a transcription factor and a master regulator for genes involved in both biofilm formation and sporulation. In B. cereus, the regulatory pathway controlling biofilm formation and cell differentiation is much less clear. In this study, we show that a novel gene, comER, plays a significant role in biofilm formation as well as sporulation in both B. subtilis and B. cereus. Mutations in the comER gene result in defects in biofilm formation and a delay in spore formation in the two Bacillus species. Our evidence supports the idea that comER may be part of the regulatory circuit that controls Spo0A activation. comER likely acts upstream of sda, a gene encoding a small checkpoint protein for both sporulation and biofilm formation, by blocking the phosphor-relay and thereby Spo0A activation. In summary, our studies outlined a conserved, positive role for comER, a gene whose function was previously uncharacterized, in the regulation of biofilm formation and sporulation in the two Bacillus species. PMID:27446060

76 FR 4338 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-25

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 January 18, 2011. Take notice that the Commission received the following electric rate filings: Docket Numbers: ER96-719-028; ER97-2801-030; ER99-2156-021; ER07- 1236-005. Applicants: MidAmerican Energy Company; PacifiCorp; Cordova Energy Company LLC; Yuma...

77 FR 56832 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER11-1850-002; ER11...: Duke Energy Carolinas, LLC. Description: Compliance Filing in Dkt. No. ER12-2161 to be effective 7/2...

76 FR 6607 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-07

..., February 17, 2011. Docket Numbers: ER11-2765-000. Applicants: Elk Wind Energy LLC. Description: Elk Wind... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 January 28..., February 18, 2011. Docket Numbers: ER10-1891-001; ER10-1896-001. Applicants: Citigroup Energy Canada ULC...

77 FR 77072 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-31

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... filings: Docket Numbers: ER10-1790-009; ER12-1400-002; ER10-2595-002. Applicants: BP Energy Company, Flat Ridge 2 Wind Energy LLC, Flat Ridge Wind Energy, LLC. Description: Updated Market Power Analysis for...

75 FR 51992 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-24

...: ER98-1150-011; ER07-1232-003; ER07-964-002. Applicants: Tucson Electric Company; UniSource Energy... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 August 16... Ventures Energy Corporation, BE Allegheny LLC, BE CA LLC, BE Ironwood LLC, BE KJ LLC, BE Alabama LLC, BE...

77 FR 12283 - Notice of FERC Staff Attendance at the Entergy Regional State Committee Meeting

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2012-02-29

...-2131 Entergy Arkansas, Inc. Docket No. ER11-2132 Entergy Gulf States, Louisiana, LLC. Docket No. ER11-2133 Entergy Gulf States, Louisiana, LLC. Docket No. ER11-2134 Entergy Mississippi, Inc. Docket No... Entergy Regional State Committee Meeting The Federal Energy Regulatory Commission hereby gives notice that...

78 FR 76607 - Combined Notice of Filings #2

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2013-12-18

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER10-2564-002; ER10-2600-002; ER10-2289-002. Applicants: Tucson Electric Power Company, UNS Electric, Inc., UniSource Energy Development Company. Description: Second...

78 FR 29363 - Combined Notice of Filings #2

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2013-05-20

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER10-1414-004; ER10-1406-005; ER10-1416-005. Applicants: Quantum Auburndale Power, LP, Quantum Lake Power, LP, Quantum Pasco Power, LP. Description: Notification of...

76 FR 67164 - Combined Notice of Filings #2

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2011-10-31

..., LLC submits tariff filing per 35.12: EGP Stillwater Solar, LLC MBR Tariff to be effective 11/15/2011... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice...-002; ER10-2140-002; ER10-2141-002; ER10- 2764-001. Applicants: Forward Energy LLC, Sheldon Energy LLC...

75 FR 6378 - Covanta Pylmouth Renewable Energy Limited Partnership Covanta Energy Marketing LLC Covanta Power...

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2010-02-09

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. ER10-395-000, ER10-409-000, ER10-410-000] Covanta Pylmouth Renewable Energy Limited Partnership Covanta Energy Marketing LLC... Pylmouth Renewable Energy Limited Partnership, Covanta Energy Marketing LLC, and Covanta Power, LLC filed...

78 FR 5436 - Combined Notice of Filings #1

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2013-01-25

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... per 11/16/2012 Order in ``ER12-1204'' & ER12-2391 eff. 10/1/2012 to be effective 10/1/2012. Filed Date: 1/15/13. Accession Number: 20130115-5119. Comments Due: 5 p.m. ET 2/5/13. Docket Numbers: ER12-2391...

77 FR 24198 - Notice of Revocation of Market-Based Rate Authority and Termination of Market-Based Rate Tariffs

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2012-04-23

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Revocation of Market-Based Rate Authority and Termination of Market-Based Rate Tariffs Docket Nos. Aleph One, Inc ER04-686-000 Alpha Domestic Power Trading, LLC........ ER08-14-000 American Power Exchange, Inc ER94-1578-000 CBA...

75 FR 26747 - U.S. Gas & Electric, Inc., Energy Services Providers, Inc., ESPI New England, Inc; Supplemental...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-12

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Docket Nos. ER10-1129-000; ER10-1130-000; ER10-1131-000] U.S. Gas & Electric, Inc., Energy Services Providers, Inc., ESPI New England, Inc... & Electric, Inc., Energy Services Providers, Inc., and ESPI New England, Inc.'s application for market-based...

Differential Regulation of Native Estrogen Receptor-Regulatory Elements by Estradiol, Tamoxifen, and Raloxifene

PubMed Central

Levy, Nitzan; Tatomer, Dierdre; Herber, Candice B.; Zhao, Xiaoyue; Tang, Hui; Sargeant, Toby; Ball, Lonnele J.; Summers, Jonathan; Speed, Terence P.; Leitman, Dale C.

2008-01-01

Estrogen receptors (ERs) regulate gene transcription by interacting with regulatory elements. Most information regarding how ER activates genes has come from studies using a small set of target genes or simple consensus sequences such as estrogen response element, activator protein 1, and Sp1 elements. However, these elements cannot explain the differences in gene regulation patterns and clinical effects observed with estradiol (E2) and selective estrogen receptor modulators. To obtain a greater understanding of how E2 and selective estrogen receptor modulators differentially regulate genes, it is necessary to investigate their action on a more comprehensive set of native regulatory elements derived from ER target genes. Here we used chromatin immunoprecipitation-cloning and sequencing to isolate 173 regulatory elements associated with ERα. Most elements were found in the introns (38%) and regions greater than 10 kb upstream of the transcription initiation site (38%); 24% of the elements were found in the proximal promoter region (<10 kb). Only 11% of the elements contained a classical estrogen response element; 23% of the elements did not have any known response elements, including one derived from the naked cuticle homolog gene, which was associated with the recruitment of p160 coactivators. Transfection studies found that 80% of the 173 elements were regulated by E2, raloxifene, or tamoxifen with ERα or ERβ. Tamoxifen was more effective than raloxifene at activating the elements with ERα, whereas raloxifene was superior with ERβ. Our findings demonstrate that E2, tamoxifen, and raloxifene differentially regulate native ER-regulatory elements isolated by chromatin immunoprecipitation with ERα and ERβ. PMID:17962382

Fine Mapping of a Gene (ER4.1) that Causes Epidermal Reticulation of Tomato Fruit and Characterization of the Associated Transcriptome

PubMed Central

Cui, Lipeng; Qiu, Zhengkun; Wang, Zhirong; Gao, Jianchang; Guo, Yanmei; Huang, Zejun; Du, Yongchen; Wang, Xiaoxuan

2017-01-01

The hydrophobic cuticle that covers the surface of tomato (Solanum lycopersicum) fruit plays key roles in development and protection against biotic and abiotic stresses, including water loss, mechanical damage, UV radiation, pathogens, and pests. However, many details of the genes and regulatory mechanisms involved in cuticle biosynthesis in fleshy fruits are not well understood. In this study, we describe a novel tomato fruit phenotype, characterized by epidermal reticulation (ER) of green fruit and a higher water loss rate than wild type (WT) fruit. The ER phenotype is controlled by a single gene, ER4.1, derived from an introgressed chromosomal segment from the wild tomato species S. pennellii (LA0716). We performed fine mapping of the single dominant gene to an ~300 kb region and identified Solyc04g082540, Solyc04g082950, Solyc04g082630, and Solyc04g082910as potential candidate genes for the ER4.1 locus, based on comparative RNA-seq analysis of ER and WT fruit peels. In addition, the transcriptome analysis revealed that the expression levels of genes involved in cutin, wax and flavonoid biosynthesis were altered in the ER fruit compared with WT. This study provides new insights into the regulatory mechanisms and metabolism of the fruit cuticle. PMID:28798753

75 FR 27338 - NASDAQ OMX Commodities Clearing-Contract Merchant LLC; NASDAQ OMX Commodities Clearing-Delivery...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. ER10-912-000; ER10-913-000; ER10-914-000] NASDAQ OMX Commodities Clearing--Contract Merchant LLC; NASDAQ OMX Commodities Clearing--Delivery LLC; NASDAQ OMX Commodities Clearing--Finance LLC; Notice of Filing May 6, 2010. Take notice that, on May 3, 2010, NASDAQ OMX Commoditie...

Uncovering a Dual Regulatory Role for Caspases During Endoplasmic Reticulum Stress-induced Cell Death

PubMed Central

Anania, Veronica G.; Yu, Kebing; Gnad, Florian; Pferdehirt, Rebecca R.; Li, Han; Ma, Taylur P.; Jeon, Diana; Fortelny, Nikolaus; Forrest, William; Ashkenazi, Avi; Overall, Christopher M.; Lill, Jennie R.

2016-01-01

Many diseases are associated with endoplasmic reticulum (ER) stress, which results from an accumulation of misfolded proteins. This triggers an adaptive response called the “unfolded protein response” (UPR), and prolonged exposure to ER stress leads to cell death. Caspases are reported to play a critical role in ER stress-induced cell death but the underlying mechanisms by which they exert their effect continue to remain elusive. To understand the role caspases play during ER stress, a systems level approach integrating analysis of the transcriptome, proteome, and proteolytic substrate profile was employed. This quantitative analysis revealed transcriptional profiles for most human genes, provided information on protein abundance for 4476 proteins, and identified 445 caspase substrates. Based on these data sets many caspase substrates were shown to be downregulated at the protein level during ER stress suggesting caspase activity inhibits their cellular function. Additionally, RNA sequencing revealed a role for caspases in regulation of ER stress-induced transcriptional pathways and gene set enrichment analysis showed expression of multiple gene targets of essential transcription factors to be upregulated during ER stress upon inhibition of caspases. Furthermore, these transcription factors were degraded in a caspase-dependent manner during ER stress. These results indicate that caspases play a dual role in regulating the cellular response to ER stress through both post-translational and transcriptional regulatory mechanisms. Moreover, this study provides unique insight into progression of the unfolded protein response into cell death, which may help identify therapeutic strategies to treat ER stress-related diseases. PMID:27125827

Uncovering a Dual Regulatory Role for Caspases During Endoplasmic Reticulum Stress-induced Cell Death.

PubMed

Anania, Veronica G; Yu, Kebing; Gnad, Florian; Pferdehirt, Rebecca R; Li, Han; Ma, Taylur P; Jeon, Diana; Fortelny, Nikolaus; Forrest, William; Ashkenazi, Avi; Overall, Christopher M; Lill, Jennie R

2016-07-01

Many diseases are associated with endoplasmic reticulum (ER) stress, which results from an accumulation of misfolded proteins. This triggers an adaptive response called the "unfolded protein response" (UPR), and prolonged exposure to ER stress leads to cell death. Caspases are reported to play a critical role in ER stress-induced cell death but the underlying mechanisms by which they exert their effect continue to remain elusive. To understand the role caspases play during ER stress, a systems level approach integrating analysis of the transcriptome, proteome, and proteolytic substrate profile was employed. This quantitative analysis revealed transcriptional profiles for most human genes, provided information on protein abundance for 4476 proteins, and identified 445 caspase substrates. Based on these data sets many caspase substrates were shown to be downregulated at the protein level during ER stress suggesting caspase activity inhibits their cellular function. Additionally, RNA sequencing revealed a role for caspases in regulation of ER stress-induced transcriptional pathways and gene set enrichment analysis showed expression of multiple gene targets of essential transcription factors to be upregulated during ER stress upon inhibition of caspases. Furthermore, these transcription factors were degraded in a caspase-dependent manner during ER stress. These results indicate that caspases play a dual role in regulating the cellular response to ER stress through both post-translational and transcriptional regulatory mechanisms. Moreover, this study provides unique insight into progression of the unfolded protein response into cell death, which may help identify therapeutic strategies to treat ER stress-related diseases. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Statistical identification of gene association by CID in application of constructing ER regulatory network

PubMed Central

Liu, Li-Yu D; Chen, Chien-Yu; Chen, Mei-Ju M; Tsai, Ming-Shian; Lee, Cho-Han S; Phang, Tzu L; Chang, Li-Yun; Kuo, Wen-Hung; Hwa, Hsiao-Lin; Lien, Huang-Chun; Jung, Shih-Ming; Lin, Yi-Shing; Chang, King-Jen; Hsieh, Fon-Jou

2009-01-01

Background A variety of high-throughput techniques are now available for constructing comprehensive gene regulatory networks in systems biology. In this study, we report a new statistical approach for facilitating in silico inference of regulatory network structure. The new measure of association, coefficient of intrinsic dependence (CID), is model-free and can be applied to both continuous and categorical distributions. When given two variables X and Y, CID answers whether Y is dependent on X by examining the conditional distribution of Y given X. In this paper, we apply CID to analyze the regulatory relationships between transcription factors (TFs) (X) and their downstream genes (Y) based on clinical data. More specifically, we use estrogen receptor α (ERα) as the variable X, and the analyses are based on 48 clinical breast cancer gene expression arrays (48A). Results The analytical utility of CID was evaluated in comparison with four commonly used statistical methods, Galton-Pearson's correlation coefficient (GPCC), Student's t-test (STT), coefficient of determination (CoD), and mutual information (MI). When being compared to GPCC, CoD, and MI, CID reveals its preferential ability to discover the regulatory association where distribution of the mRNA expression levels on X and Y does not fit linear models. On the other hand, when CID is used to measure the association of a continuous variable (Y) against a discrete variable (X), it shows similar performance as compared to STT, and appears to outperform CoD and MI. In addition, this study established a two-layer transcriptional regulatory network to exemplify the usage of CID, in combination with GPCC, in deciphering gene networks based on gene expression profiles from patient arrays. Conclusion CID is shown to provide useful information for identifying associations between genes and transcription factors of interest in patient arrays. When coupled with the relationships detected by GPCC, the association predicted by CID are applicable to the construction of transcriptional regulatory networks. This study shows how information from different data sources and learning algorithms can be integrated to investigate whether relevant regulatory mechanisms identified in cell models can also be partially re-identified in clinical samples of breast cancers. Availability the implementation of CID in R codes can be freely downloaded from . PMID:19292896

77 FR 23475 - PJM Interconnection, L.L.C., Duke Energy Ohio, Inc., Duke Energy Kentucky, Inc; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. ER12-91-000, ER12-91-002, ER12-92-002] PJM Interconnection, L.L.C., Duke Energy Ohio, Inc., Duke Energy Kentucky, Inc; Notice of Filing Take notice that on April 5, 2012, Duke Energy Ohio, Inc. and Duke Energy Kentucky, Inc., tendered...

BARC: A Novel Apoptosis Regulator

DTIC Science & Technology

2005-06-01

of other well-character- pathway for apoptosis. ized cell death-regulatory genes, including caspase 12, Because ischemia - reperfusion injury is known...in- creased sensitivity of cultured neurons to ischemia - cluding induction of ER chaperones associated with un- reperfusion injury , we compared bi-1...induced apoptosis. BI-1 and anti-apoptotic Bcl - 2 -family protein, regulate ER calcium. Our work revealed structural elements in Bcl - 2 and other ER

77 FR 50510 - Federal Agency Responses to Interagency Coordinating Committee on the Validation of Alternative...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-21

... methods for potential use in the EPA EDSP. The evaluation indicated that no in vitro ER- or AR-based test... considered a high priority based on the lack of adequately validated test methods and the regulatory and... Limitations of the LUMI-CELL[supreg] ER (BG1Luc ER TA) Test Method, An In Vitro Assay for Identifying Human...

77 FR 54907 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-06

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER10-2601-001; ER10-2605-003. Applicants: Power Resources, Ltd., Yuma Cogeneration Associates. Description: Notification of...

The CCAAT box in the proximal SERCA2 gene promoter regulates basal and stress-induced transcription in cardiomyocytes.

PubMed

Fragoso-Medina, Jorge; Rodriguez, Gabriela; Zarain-Herzberg, Angel

2018-05-01

The cardiac sarco/endoplasmic reticulum Ca 2+ -ATPase-2a (SERCA2a) is vital for the correct handling of calcium concentration in cardiomyocytes. Recent studies showed that the induction of endoplasmic reticulum (ER) stress (ERS) with the SERCA2 inhibitor Thapsigargin (Tg) increases the mRNA and protein levels of SERCA2a. The SERCA2 gene promoter contains an ERS response element (ERSE) at position -78 bp that is conserved among species and might transcriptionally regulate SERCA2 gene expression. However, its involvement in SERCA2 basal and calcium-mediated transcriptional activation has not been elucidated. In this work, we show that in cellular cultures of neonatal rat ventricular myocytes, the treatment with Tg or the calcium ionophore A23187 increases the SERCA2a mRNA and protein abundance, as well as the transcriptional activity of two chimeric human SERCA2 gene constructs, containing -254 and -2579 bp of 5'-regulatory region cloned in the pGL3-basic vector and transiently transfected in cultured cardiomyocytes. We found that the ERSE present in the SERCA2 proximal promoter contains a CCAAT box that is involved in basal and ERS-mediated hSERCA2 transcriptional activation. The EMSA results showed that the CCAAT box present in the ERSE recruits the NF-Y transcription factor. Additionally, by ChIP assays, we confirmed in vivo binding of NF-Y and C/EBPβ transcription factors to the SERCA2 gene proximal promoter.

78 FR 6816 - Combined Notice of Filings #2

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2013-01-31

...: UniSource Energy Development Company. Description: UniSource Energy Development Company submits tariff... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER10-2460-004; ER10...

76 FR 69264 - Combined Notice of Filings #1

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2011-11-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER10-3069-002; ER10-3070-002. Applicants: Alcoa Power Generating Inc. Description: Alcoa Power Generating Inc. and Alcoa...

77 FR 25161 - Combined Notice of Filings #2

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2012-04-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER10-1484-002... Numbers: ER12-1573-000. Applicants: The Detroit Edison Company. Description: Thumb Electric WPS-2 Service...

77 FR 41976 - Combined Notice of Filings #2

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2012-07-17

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER10-1825-001; ER10-1827-001. Applicants: Cleco Power LLC, Cleco Evangeline LLC. Description: Responses to Information...

76 FR 80922 - Combined Notice of Filings #1

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2011-12-27

... Energy, Inc. Description: Tennessee Valley Authority BA Opers Coordination Agreement (Caney River Wind... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... electric rate filings: Docket Numbers: ER10-3079-001; ER12-126-001. Applicants: Tyr Energy, LLC, Trademark...

78 FR 17391 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-21

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER109-1997-000; ER10-1997-001. Applicants: Midwest Independent Transmission System Operator, Inc. Description: Informational Response of The Midwest Independent...

75 FR 9892 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-04

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 February 24, 2010. Take notice that the Commission received the following electric rate filings: Docket Numbers: ER99-1005-005; ER09-304-002. Applicants: KCP&L Greater Missouri Operations Company; Kansas City Power...

78 FR 2383 - Combined Notice of Filings #2

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2013-01-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice.../13. Docket Numbers: ER10-3079-004; ER12-126-006. Applicants: Tyr Energy, LLC, Trademark Merchant Energy, LLC. Description: Updated Market Power Analysis for the Southwest Power Pool Region of Tyr Energy...

75 FR 40812 - Combined Notice of Filings #1

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2010-07-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 July 2..., 2010. Docket Numbers: ER98-3184-012; ER00-494-006. Applicants: TransAlta Energy Marketing (U.S.) Inc... Energy, LLC. Description: Avista Corporation et al. submits their triennial market power study. Filed...

76 FR 64339 - Combined Notice of Filings #1

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2011-10-18

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER04-157-033; ER04-714-022; EL05-89-011. Applicants: Bangor Hydro-Electric Company; Florida Power & Light Company New...

77 FR 20815 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-06

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER04-157-034; ER04-714-023; EL05-89-012. Applicants: Bangor Hydro-Electric Company, Florida Power & Light Company--New...

Pathway Analysis Revealed Potential Diverse Health Impacts of Flavonoids that Bind Estrogen Receptors

PubMed Central

Ye, Hao; Ng, Hui Wen; Sakkiah, Sugunadevi; Ge, Weigong; Perkins, Roger; Tong, Weida; Hong, Huixiao

2016-01-01

Flavonoids are frequently used as dietary supplements in the absence of research evidence regarding health benefits or toxicity. Furthermore, ingested doses could far exceed those received from diet in the course of normal living. Some flavonoids exhibit binding to estrogen receptors (ERs) with consequential vigilance by regulatory authorities at the U.S. EPA and FDA. Regulatory authorities must consider both beneficial claims and potential adverse effects, warranting the increases in research that has spanned almost two decades. Here, we report pathway enrichment of 14 targets from the Comparative Toxicogenomics Database (CTD) and the Herbal Ingredients’ Targets (HIT) database for 22 flavonoids that bind ERs. The selected flavonoids are confirmed ER binders from our earlier studies, and were here found in mainly involved in three types of biological processes, ER regulation, estrogen metabolism and synthesis, and apoptosis. Besides cancers, we conjecture that the flavonoids may affect several diseases via apoptosis pathways. Diseases such as amyotrophic lateral sclerosis, viral myocarditis and non-alcoholic fatty liver disease could be implicated. More generally, apoptosis processes may be importantly evolved biological functions of flavonoids that bind ERs and high dose ingestion of those flavonoids could adversely disrupt the cellular apoptosis process. PMID:27023590

Influence of Drug Properties and Formulation on In Vitro Drug Release and Biowaiver Regulation of Oral Extended Release Dosage Forms.

PubMed

Lin, Zhongqiang; Zhou, Deliang; Hoag, Stephen; Qiu, Yihong

2016-03-01

Bioequivalence (BE) studies are often required to ensure therapeutic equivalence for major product and manufacturing changes. Waiver of a BE study (biowaiver) is highly desired for such changes. Current regulatory guidelines allow for biowaiver of proportionally similar lower strengths of an extended release (ER) product provided it exhibits similar dissolution to the higher strength in multimedia. The objective of this study is to demonstrate that (1) proportionally similar strengths of ER tablets exhibiting similar in vitro dissolution profiles do not always assure BE and (2) different strengths that do not meet the criteria for dissolution profile similarity may still be bioequivalent. Four marketed ER tablets were used as model drug products. Higher and lower (half) strength tablets were prepared or obtained from commercial source. In vitro drug release was compared using multi-pH media (pH 1.2, 4.5, 6.8) per regulatory guidance. In vivo performance was assessed based on the available in vivo BE data or established in vitro-in vivo relationships. This study demonstrated that the relationship between in vitro dissolution and in vivo performance is complex and dependent on the characteristics of specific drug molecules, product design, and in vitro test conditions. As a result, proportionally similar strengths of ER dosage forms that meet biowaiver requirements per current regulatory guidelines cannot ensure bioequivalence in all cases. Thus, without an established relationship between in vitro and in vivo performance, granting biowaiver based on passing in vitro tests may result in the approval of certain bioinequivalent products, presenting risks to patients. To justify any biowaiver using in vitro test, it is essential to understand the effects of drug properties, formulation design, product characteristics, test method, and its in vivo relevance. Therefore, biowaiver requirements of different strengths of ER dosage forms specified in the current regulatory guidance should be reevaluated to assure consistent safety and efficacy among different strengths.

Sequential Actions of the AAA-ATPase Valosin-containing Protein (VCP)/p97 and the Proteasome 19 S Regulatory Particle in Sterol-accelerated, Endoplasmic Reticulum (ER)-associated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase*

PubMed Central

Morris, Lindsey L.; Hartman, Isamu Z.; Jun, Dong-Jae; Seemann, Joachim; DeBose-Boyd, Russell A.

2014-01-01

Accelerated endoplasmic reticulum (ER)-associated degradation (ERAD) of the cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase results from its sterol-induced binding to ER membrane proteins called Insig-1 and Insig-2. This binding allows for subsequent ubiquitination of reductase by Insig-associated ubiquitin ligases. Once ubiquitinated, reductase becomes dislocated from ER membranes into the cytosol for degradation by 26 S proteasomes through poorly defined reactions mediated by the AAA-ATPase valosin-containing protein (VCP)/p97 and augmented by the nonsterol isoprenoid geranylgeraniol. Here, we report that the oxysterol 25-hydroxycholesterol and geranylgeraniol combine to trigger extraction of reductase across ER membranes prior to its cytosolic release. This conclusion was drawn from studies utilizing a novel assay that measures membrane extraction of reductase by determining susceptibility of a lumenal epitope in the enzyme to in vitro protease digestion. Susceptibility of the lumenal epitope to protease digestion and thus membrane extraction of reductase were tightly regulated by 25-hydroxycholesterol and geranylgeraniol. The reaction was inhibited by RNA interference-mediated knockdown of either Insigs or VCP/p97. In contrast, reductase continued to become membrane-extracted, but not cytosolically dislocated, in cells deficient for AAA-ATPases of the proteasome 19 S regulatory particle. These findings establish sequential roles for VCP/p97 and the 19 S regulatory particle in the sterol-accelerated ERAD of reductase that may be applicable to the ERAD of other substrates. PMID:24860107

Biochemical evidence that regulation of Ero1β activity in human cells does not involve the isoform-specific cysteine 262

PubMed Central

Hansen, Henning G.; Søltoft, Cecilie L.; Schmidt, Jonas D.; Birk, Julia; Appenzeller-Herzog, Christian; Ellgaard, Lars

2014-01-01

In the ER (endoplasmic reticulum) of human cells, disulfide bonds are predominantly generated by the two isoforms of Ero1 (ER oxidoreductin-1): Ero1α and Ero1β. The activity of Ero1α is tightly regulated through the formation of intramolecular disulfide bonds to help ensure balanced ER redox conditions. Ero1β is less tightly regulated, but the molecular details underlying control of activity are not as well characterized as for Ero1α. Ero1β contains an additional cysteine residue (Cys262), which has been suggested to engage in an isoform-specific regulatory disulfide bond with Cys100. However, we show that the two regulatory disulfide bonds in Ero1α are likely conserved in Ero1β (Cys90–Cys130 and Cys95–Cys100). Molecular modelling of the Ero1β structure predicted that the side chain of Cys262 is completely buried. Indeed, we found this cysteine to be reduced and partially protected from alkylation in the ER of living cells. Furthermore, mutation of Cys100–but not of Cys262–rendered Ero1β hyperactive in cells, as did mutation of Cys130. Ero1β hyperactivity induced the UPR (unfolded protein response) and resulted in oxidative perturbation of the ER redox state. We propose that features other than a distinct pattern of regulatory disulfide bonds determine the loose redox regulation of Ero1β relative to Ero1α. PMID:27919037

78 FR 70548 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-26

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER10-1246-006; ER10... Agreements Re-Collation Part 1 to be effective 11/20/2013. Filed Date: 11/19/13. Accession Number: 20131119...

76 FR 64937 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... Time on Tuesday, November 1, 2011. Docket Numbers: ER10-3069-002. Applicants: Alcoa Power Generating...-5117. Comment Date: 5 p.m. Eastern Time on Tuesday, November 1, 2011. Docket Numbers: ER10-3070-002...

77 FR 33212 - Notice of FERC Staff Attendance at the Entergy Regional State Committee Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-05

... Gulf States, Louisiana, LLC Docket No. ER11-2133 Entergy Gulf States, Louisiana, LLC Docket No. ER11... Entergy Regional State Committee Meeting The Federal Energy Regulatory Commission (Commission) hereby... the Commission's ongoing outreach efforts. Entergy Regional State Committee Meeting June 6, 2012-June...

77 FR 48510 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER10-1823-001; ER10...: Attachment K Compliance Filing--SD OATT to be effective 8/2/2012. Filed Date: 8/7/12. Accession Number...

77 FR 65872 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-31

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice...: ER12-2640-001. Applicants: Electric Energy, Inc. Description: Electric Energy, Inc. submits tariff...-5014. Comments Due: 5 p.m. ET 11/14/12. Docket Numbers: ER13-167-001. Applicants: Caerus Energy, LLC...

75 FR 13529 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-22

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 March 15..., 2010. Docket Numbers: ER09-1099-003; ER07-412-004. Applicants: Empire Generating Co, LLC; ECP Energy I, LLC. Description: Quarterly Report of ECP Energy I, LLC, and Empire Generating Co, LLC. Filed Date: 02...

78 FR 25071 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-29

...: OA07-52-005; ER08-28-003. Applicants: Puget Sound Energy, Inc. Description: Puget Sound Energy, Inc... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice...; ER10-1862-003. Applicants: Calpine Oneta Power, LLC, Calpine Energy Services, L.P., Calpine Power...

Mitochondrial metabolic regulation by GRP78

PubMed Central

Prasad, Manoj; Pawlak, Kevin J.; Burak, William E.; Perry, Elizabeth E.; Marshall, Brendan; Whittal, Randy M.; Bose, Himangshu S.

2017-01-01

Steroids, essential for mammalian survival, are initiated by cholesterol transport by steroidogenic acute regulatory protein (StAR). Appropriate protein folding is an essential requirement of activity. Endoplasmic reticulum (ER) chaperones assist in folding of cytoplasmic proteins, whereas mitochondrial chaperones fold only mitochondrial proteins. We show that glucose regulatory protein 78 (GRP78), a master ER chaperone, is also present at the mitochondria-associated ER membrane (MAM), where it folds StAR for delivery to the outer mitochondrial membrane. StAR expression and activity are drastically reduced following GRP78 knockdown. StAR folding starts at the MAM region; thus, its cholesterol fostering capacity is regulated by GRP78 long before StAR reaches the mitochondria. In summary, GRP78 is an acute regulator of steroidogenesis at the MAM, regulating the intermediate folding of StAR that is crucial for its activity. PMID:28275724

Regulation of endoplasmic reticulum turnover by selective autophagy.

PubMed

Khaminets, Aliaksandr; Heinrich, Theresa; Mari, Muriel; Grumati, Paolo; Huebner, Antje K; Akutsu, Masato; Liebmann, Lutz; Stolz, Alexandra; Nietzsche, Sandor; Koch, Nicole; Mauthe, Mario; Katona, Istvan; Qualmann, Britta; Weis, Joachim; Reggiori, Fulvio; Kurth, Ingo; Hübner, Christian A; Dikic, Ivan

2015-06-18

The endoplasmic reticulum (ER) is the largest intracellular endomembrane system, enabling protein and lipid synthesis, ion homeostasis, quality control of newly synthesized proteins and organelle communication. Constant ER turnover and modulation is needed to meet different cellular requirements and autophagy has an important role in this process. However, its underlying regulatory mechanisms remain unexplained. Here we show that members of the FAM134 reticulon protein family are ER-resident receptors that bind to autophagy modifiers LC3 and GABARAP, and facilitate ER degradation by autophagy ('ER-phagy'). Downregulation of FAM134B protein in human cells causes an expansion of the ER, while FAM134B overexpression results in ER fragmentation and lysosomal degradation. Mutant FAM134B proteins that cause sensory neuropathy in humans are unable to act as ER-phagy receptors. Consistently, disruption of Fam134b in mice causes expansion of the ER, inhibits ER turnover, sensitizes cells to stress-induced apoptotic cell death and leads to degeneration of sensory neurons. Therefore, selective ER-phagy via FAM134 proteins is indispensable for mammalian cell homeostasis and controls ER morphology and turnover in mice and humans.

77 FR 23709 - Combined Notice of Filings #3

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-20

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 3 Take notice... Date: 4/12/12. Accession Number: 20120412-5054. Comments Due: 5 p.m. ET 5/3/12. Docket Numbers: ER12.... Accession Number: 20120412-5081. Comments Due: 5 p.m. ET 5/3/12. Docket Numbers: ER12-1525-000. Applicants...

77 FR 67810 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER10-2719-010; ER10... per 35.13(a)(2)(iii: Amended IFA with Cabazon Wind Partners, LLC to be effective 1/6/2013. Filed Date...

76 FR 42704 - Sky River LLC; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. ER11-3277-000; ER11-3277-001] Sky River LLC; Notice of Filing Take notice that, on July 8, 2011, Sky River LLC filed to amend its Open Access Transmission Tariff (OATT) filing, submitted on April 1, 2011 and amended on April 7...

78 FR 42516 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-16

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER11-2119-000. Applicants: Entergy Texas, Inc. Description: Refund Report--Docket No. ER11-2161, to be effective N/A. Filed Date: 7/9/13. Accession Number: 20130709...

78 FR 54462 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-04

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER11-3576-010;ER11-3401-009. Applicants: Golden Spread Electric Cooperative, Inc., Golden Spread Panhandle Wind Ranch, LLC. Description: Notice of Change in Status of...

Spaceborne radar interferometry for coastal DEM construction

USGS Publications Warehouse

Hong, S.-H.; Lee, C.-W.; Won, J.-S.; Kwoun, Oh-Ig; Lu, Z.

2005-01-01

Topographic features in coastal regions including tidal flats change more significantly than landmass, and are characterized by extremely low slopes. High precision DEMs are required to monitor dynamic changes in coastal topography. It is difficult to obtain coherent interferometric SAR pairs especially over tidal flats mainly because of variation of tidal conditions. Here we focus on i) coherence of multi-pass ERS SAR interferometric pairs and ii) DEM construction from ERS-ENVISAT pairs. Coherences of multi-pass ERS interferograms were good enough to construct DEM under favorable tidal conditions. Coherence in sand dominant area was generally higher than that in muddy surface. The coarse grained coastal areas are favorable for multi-pass interferometry. Utilization of ERS-ENVISAT interferometric pairs is taken a growing interest. We carried out investigation using a cross-interferometric pair with a normal baseline of about 1.3 km, a 30 minutes temporal separation and the height sensitivity of about 6 meters. Preliminary results of ERS-ENVISAT interferometry were not successful due to baseline and unfavorable scattering conditions. ?? 2005 IEEE.

Dissecting and engineering of the TetR family regulator SACE_7301 for enhanced erythromycin production in Saccharopolyspora erythraea.

PubMed

Wu, Hang; Chen, Meng; Mao, Yongrong; Li, Weiwei; Liu, Jingtao; Huang, Xunduan; Zhou, Ying; Ye, Bang-Ce; Zhang, Lixin; Weaver, David T; Zhang, Buchang

2014-11-13

Saccharopolyspora erythraea was extensively utilized for the industrial-scale production of erythromycin A (Er-A), a macrolide antibiotic commonly used in human medicine. Yet, S. erythraea lacks regulatory genes in the erythromycin biosynthetic gene (ery) cluster, hampering efforts to enhance Er-A production via the engineering of regulatory genes. By the chromosome gene inactivation technique based on homologous recombination with linearized DNA fragments, we have inactivated a number of candidate TetR family transcriptional regulators (TFRs) and identified one TFR (SACE_7301) positively controlling erythromycin biosynthesis in S. erythraea A226. qRT-PCR and EMSA analyses demonstrated that SACE_7301 activated the transcription of erythromycin biosynthetic gene eryAI and the resistance gene ermE by interacting with their promoter regions with low affinities, similar to BldD (SACE_2077) previously identified to regulate erythromycin biosynthesis and morphological differentiation. Therefore, we designed a strategy for overexpressing SACE_7301 with 1 to 3 extra copies under the control of PermE* in A226. Following up-regulated transcriptional expression of SACE_7301, eryAI and ermE, the SACE_7301-overexpressed strains all increased Er-A production over A226 proportional to the number of copies. Likewise, when SACE_7301 was overexpressed in an industrial S. erythraea WB strain, Er-A yields of the mutants WB/7301, WB/2×7301 and WB/3×7301 were respectively increased by 17%, 29% and 42% relative to that of WB. In a 5 L fermentor, Er-A accumulation increased to 4,230 mg/L with the highest-yield strain WB/3×7301, an approximately 27% production improvement over WB (3,322 mg/L). We have identified and characterized a TFR, SACE_7301, in S. erythraea that positively regulated erythromycin biosynthesis, and overexpression of SACE_7301 in wild-type and industrial S. erythraea strains enhanced Er-A yields. This study markedly improves our understanding of the unusual regulatory mechanism of erythromycin biosynthesis, and provides a novel strategy towards Er-A overproduction by engineering transcriptional regulators of S. erythraea.

77 FR 21978 - Notice of Commission Staff Attendance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-12

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the... Transmission LLC. Docket No. EL12-28 Xcel Energy. Docket No. ER12-1357 Louisville Gas and Electric Company...

76 FR 67721 - PNE Energy Supply, LLC;

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-02

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-186-000] PNE Energy... Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of PNE Energy... file with the Federal Energy Regulatory Commission, 888 First Street, NE., Washington, DC 20426, in...

[Ecological risk assessment of dam construction for terrestrial plant species in middle reach of Lancangjiang River, Southwest China].

PubMed

Li, Xiao-Yan; Dong, Shi-Kui; Liu, Shi-Liang; Peng, Ming-Chun; Li, Jin-Peng; Zhao, Qing-He; Zhang, Zhao-Ling

2012-08-01

Taking the surrounding areas of Xiaowan Reservoir in the middle reach of Lancangjiang River as study area, and based on the vegetation investigation at three sites including electricity transmission area (site 1), electricity-transfer substation and roadsides to the substation (site 2), and emigration area (site 3) in 1997 (before dam construction), another investigation was conducted on the vegetation composition, plant coverage, and dominant species at the same sites in 2010 (after dam construction), aimed to evaluate the ecological risk of the dam construction for the terrestrial plant species in middle reach of Lancangjiang River. There was an obvious difference in the summed dominance ratio of dominant species at the three sites before and after the dam construction. According the types of species (dominant and non-dominant species) and the changes of plant dominance, the ecological risk (ER) for the plant species was categorized into 0 to IV, i.e., no or extremely low ecological risk (0), low ecological risk (I), medium ecological risk (II), high ecological risk (III), and extremely high ecological risk (IV). As affected by the dam construction, the majority of the species were at ER III, and a few species were at ER IV. The percentage of the plant species at ER III and ER IV at site 3 was higher than that at sites 1 and 2. The decrease or loss of native plants and the increase of alien or invasive plants were the major ecological risks caused by the dam construction. Effective protection strategies should be adopted to mitigate the ecological risk of the dam construction for the terrestrial plants at species level.

77 FR 45599 - CED Rock Springs, Inc.; Supplemental Notice That Revised Market-Based Rate Tariff Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket Nos. ER02-2546-000; ER02-2546-001] CED Rock Springs, Inc.; Supplemental Notice That Revised Market- Based Rate Tariff Filing...-referenced proceeding of CED Rock Springs, Inc.'s tariff revision filing, noting that such filing includes a...

78 FR 62360 - PJM Interconnection, L.L.C.; Notice of Technical Conference

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-21

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-2108-000] PJM Interconnection, L.L.C.; Notice of Technical Conference Federal Energy Regulatory Commission (Commission) staff... consider issues related to PJM Interconnection, L.L.C.'s (PJM) proposed demand response plan enhancements...

Endoplasmic Reticulum Transport of Glutathione by Sec61 Is Regulated by Ero1 and Bip.

PubMed

Ponsero, Alise J; Igbaria, Aeid; Darch, Maxwell A; Miled, Samia; Outten, Caryn E; Winther, Jakob R; Palais, Gael; D'Autréaux, Benoit; Delaunay-Moisan, Agnès; Toledano, Michel B

2017-09-21

In the endoplasmic reticulum (ER), Ero1 catalyzes disulfide bond formation and promotes glutathione (GSH) oxidation to GSSG. Since GSSG cannot be reduced in the ER, maintenance of the ER glutathione redox state and levels likely depends on ER glutathione import and GSSG export. We used quantitative GSH and GSSG biosensors to monitor glutathione import into the ER of yeast cells. We found that glutathione enters the ER by facilitated diffusion through the Sec61 protein-conducting channel, while oxidized Bip (Kar2) inhibits transport. Increased ER glutathione import triggers H 2 O 2 -dependent Bip oxidation through Ero1 reductive activation, which inhibits glutathione import in a negative regulatory loop. During ER stress, transport is activated by UPR-dependent Ero1 induction, and cytosolic glutathione levels increase. Thus, the ER redox poise is tuned by reciprocal control of glutathione import and Ero1 activation. The ER protein-conducting channel is permeable to small molecules, provided the driving force of a concentration gradient. Copyright © 2017 Elsevier Inc. All rights reserved.

Effects-based chemical category approach for prioritization of low affinity estrogenic chemicals.

PubMed

Hornung, M W; Tapper, M A; Denny, J S; Kolanczyk, R C; Sheedy, B R; Hartig, P C; Aladjov, H; Henry, T R; Schmieder, P K

2014-01-01

Regulatory agencies are charged with addressing the endocrine disrupting potential of large numbers of chemicals for which there is often little or no data on which to make decisions. Prioritizing the chemicals of greatest concern for further screening for potential hazard to humans and wildlife is an initial step in the process. This paper presents the collection of in vitro data using assays optimized to detect low affinity estrogen receptor (ER) binding chemicals and the use of that data to build effects-based chemical categories following QSAR approaches and principles pioneered by Gilman Veith and colleagues for application to environmental regulatory challenges. Effects-based chemical categories were built using these QSAR principles focused on the types of chemicals in the specific regulatory domain of concern, i.e. non-steroidal industrial chemicals, and based upon a mechanistic hypothesis of how these non-steroidal chemicals of seemingly dissimilar structure to 17ß-estradiol (E2) could interact with the ER via two distinct binding types. Chemicals were also tested to solubility thereby minimizing false negatives and providing confidence in determination of chemicals as inactive. The high-quality data collected in this manner were used to build an ER expert system for chemical prioritization described in a companion article in this journal.

78 FR 32383 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-30

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER09-548-002; EC11-108-001. Applicants: ITC Great Plains, LLC. Description: ITC Great Plains, LLC submits compliance filing to Begin Amortization of Regulatory Assets...

Self- and Co-regulation of Anger and Fear in Preschoolers with Autism Spectrum Disorders: The Role of Maternal Parenting Style and Temperament.

PubMed

Hirschler-Guttenberg, Yael; Feldman, Ruth; Ostfeld-Etzion, Sharon; Laor, Nathaniel; Golan, Ofer

2015-09-01

Emotion regulation (ER) difficulties are a major concern in children with autism spectrum disorder (ASD). Maternal temperament and parenting style have significant effects on children's ER. However, these effects have not been studied in children with ASD. Forty preschoolers with ASD and their mothers and forty matched controls engaged in fear and anger ER paradigms, micro-coded for child self- and co-regulatory behaviors and parent's regulation-facilitation. Mothers' parenting style and temperament were self-reported. In the ASD group only, maternal authoritarian style predicted higher self-regulation and lower co-regulation of anger and maternal authoritative style predicted higher self-regulation of fear. Maternal temperament did not predict child's ER. Findings emphasize the importance of maternal flexible parenting style in facilitating ER among children with ASD.

Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress.

PubMed

Takayanagi, Sayuri; Fukuda, Riga; Takeuchi, Yuuki; Tsukada, Sakiko; Yoshida, Kenichi

2013-01-01

In the endoplasmic reticulum (ER), secretory and membrane proteins are properly folded and modified, and the failure of these processes leads to ER stress. At the same time, unfolded protein response (UPR) genes are activated to maintain homeostasis. Despite the thorough characterization of the individual gene regulation of UPR genes to date, further investigation of the mutual regulation among UPR genes is required to understand the complex mechanism underlying the ER stress response. In this study, we aimed to reveal a gene regulatory network formed by UPR genes, including immunoglobulin heavy chain-binding protein (BiP), X-box binding protein 1 (XBP1), C/EBP [CCAAT/enhancer-binding protein]-homologous protein (CHOP), PKR-like endoplasmic reticulum kinase (PERK), inositol-requiring 1 (IRE1), activating transcription factor 6 (ATF6), and ATF4. For this purpose, we focused on promoter-luciferase reporters for BiP, XBP1, and CHOP genes, which bear an ER stress response element (ERSE), and p5 × ATF6-GL3, which bears an unfolded protein response element (UPRE). We demonstrated that the luciferase activities of the BiP and CHOP promoters were upregulated by all the UPR genes, whereas those of the XBP1 promoter and p5 × ATF6-GL3 were upregulated by all the UPR genes except for BiP, CHOP, and ATF4 in HeLa cells. Therefore, an ERSE- and UPRE-centered gene regulatory network of UPR genes could be responsible for the robustness of the ER stress response. Finally, we revealed that BiP protein was degraded when cells were treated with DNA-damaging reagents, such as etoposide and doxorubicin; this finding suggests that the expression level of BiP is tightly regulated at the post-translational level, rather than at the transcriptional level, in the presence of DNA damage.

23 CFR 668.105 - Policy.

Code of Federal Regulations, 2010 CFR

2010-04-01

... as best suited to protect the public health and safety. (j) ER program funding is only to be used to... feasible, the cost of permanent restoration work. (d) The approval to use available ER funds to repair or... over non-emergency work. (h) ER projects shall be promptly constructed. Any project that has not...

Emotions and Emotion Regulation in Breast Cancer Survivorship

PubMed Central

Conley, Claire C.; Bishop, Brenden T.; Andersen, Barbara L.

2016-01-01

Emotional distress in cancer patients is an important outcome; however, emotional experience does not begin and end with emotion generation. Attempts to regulate emotions may lessen their potentially negative effects on physical and psychological well-being. Researchers have called for the study of emotion regulation (ER) in health psychology and psycho-oncology. Thus, this review has three aims. First, we discuss current understandings of emotion and ER across the cancer trajectory, including the principles of ER and methods for its assessment. Second, we present a model for examining the mediating effects of ER on psychosocial outcomes. Third, we “round out” the discussion with an example: new data on the role of ER in recurrent breast cancer. Taken together, these aims illustrate the impact of affective regulatory processes on cancer patients’ long-term outcomes. As survival rates increase, long-term follow-up studies are needed to characterize the dynamic, reciprocal effects of emotion and ER for cancer survivors. Further research on ER may help women with breast cancer better manage the challenges associated with diagnosis and treatment. PMID:27517969

Reappraisal and suppression mediate the contribution of regulatory focus to anxiety in healthy adults.

PubMed

Llewellyn, Nicole; Dolcos, Sanda; Iordan, Alexandru D; Rudolph, Karen D; Dolcos, Florin

2013-08-01

Theory and research link regulatory focus (RF) in the form of promotion and prevention goal orientation with internalizing symptoms (e.g., anxiety), but the relevant mechanisms are not well understood. This study investigated the role of two emotion regulation (ER) strategies (cognitive reappraisal and expressive suppression) as possible mediators. Path analysis using data from 179 healthy young participants (110 women, 69 men) revealed that stronger promotion orientation was significantly associated with less anxiety, and that the use of reappraisal and suppression partially mediated this association. Prevention was associated with more suppression but was not directly associated with anxiety. There were no gender differences in these effects. Collectively, these findings suggest that effective ER, through heightened use of reappraisal and dampened use of suppression, serves as a mechanism through which promotion confers protection against anxiety. This research provides empirical support to initiatives aimed at promoting healthy psychological adjustment and preventing anxiety, by optimizing ER strategies with respect to RF goal orientations. PsycINFO Database Record (c) 2013 APA, all rights reserved.

Mothering, fathering, and the regulation of negative and positive emotions in high-functioning preschoolers with autism spectrum disorder.

PubMed

Hirschler-Guttenberg, Yael; Golan, Ofer; Ostfeld-Etzion, Sharon; Feldman, Ruth

2015-05-01

Children with autism spectrum disorder (ASD) exhibit difficulties in regulating emotions and authors have called to study the specific processes underpinning emotion regulation (ER) in ASD. Yet, little observational research examined the strategies preschoolers with ASD use to regulate negative and positive emotions in the presence of their mothers and fathers. Forty preschoolers with ASD and 40 matched typically developing children and their mothers and fathers participated. Families were visited twice for identical battery of paradigms with mother or father. Parent-child interactions were coded for parent and child behaviors and children engaged in ER paradigms eliciting negative (fear) and positive (joy) emotions with each parent. ER paradigms were microcoded for negative and positive emotionality, ER strategies, and parent regulation facilitation. During free play, mothers' and fathers' sensitivity and warm discipline were comparable across groups; however, children with ASD displayed lower positive engagement and higher withdrawal. During ER paradigms, children with ASD expressed less positive emotionality overall and more negative emotionality during fear with father. Children with ASD used more simple self-regulatory strategies, particularly during fear, but expressed comparable levels of assistance seeking behavior toward mother and father in negative and positive contexts. Parents of children with ASD used less complex regulation facilitation strategies, including cognitive reappraisal and emotional reframing, and employed simple tactics, such as physical comforting to manage fear and social gaze to maintain joy. Findings describe general and parent- and emotion-specific processes of child ER and parent regulation facilitation in preschoolers with ASD. Results underscore the ability of such children to seek parental assistance during moments of high arousal and the parents' sensitive adaptation to their children's needs. Reduced positive emotionality, rather than increased negative reactivity and self-regulatory efforts, emerges as the consistent element associated with ER processes in this group. © 2014 Association for Child and Adolescent Mental Health.

Construction of environmental risk score beyond standard linear models using machine learning methods: application to metal mixtures, oxidative stress and cardiovascular disease in NHANES.

PubMed

Park, Sung Kyun; Zhao, Zhangchen; Mukherjee, Bhramar

2017-09-26

There is growing concern of health effects of exposure to pollutant mixtures. We initially proposed an Environmental Risk Score (ERS) as a summary measure to examine the risk of exposure to multi-pollutants in epidemiologic research considering only pollutant main effects. We expand the ERS by consideration of pollutant-pollutant interactions using modern machine learning methods. We illustrate the multi-pollutant approaches to predicting a marker of oxidative stress (gamma-glutamyl transferase (GGT)), a common disease pathway linking environmental exposure and numerous health endpoints. We examined 20 metal biomarkers measured in urine or whole blood from 6 cycles of the National Health and Nutrition Examination Survey (NHANES 2003-2004 to 2013-2014, n = 9664). We randomly split the data evenly into training and testing sets and constructed ERS's of metal mixtures for GGT using adaptive elastic-net with main effects and pairwise interactions (AENET-I), Bayesian additive regression tree (BART), Bayesian kernel machine regression (BKMR), and Super Learner in the training set and evaluated their performances in the testing set. We also evaluated the associations between GGT-ERS and cardiovascular endpoints. ERS based on AENET-I performed better than other approaches in terms of prediction errors in the testing set. Important metals identified in relation to GGT include cadmium (urine), dimethylarsonic acid, monomethylarsonic acid, cobalt, and barium. All ERS's showed significant associations with systolic and diastolic blood pressure and hypertension. For hypertension, one SD increase in each ERS from AENET-I, BART and SuperLearner were associated with odds ratios of 1.26 (95% CI, 1.15, 1.38), 1.17 (1.09, 1.25), and 1.30 (1.20, 1.40), respectively. ERS's showed non-significant positive associations with mortality outcomes. ERS is a useful tool for characterizing cumulative risk from pollutant mixtures, with accounting for statistical challenges such as high degrees of correlations and pollutant-pollutant interactions. ERS constructed for an intermediate marker like GGT is predictive of related disease endpoints.

The Endoplasmic Reticulum Is a Reservoir for WAVE/SCAR Regulatory Complex Signaling in the Arabidopsis Leaf1[W][OA

PubMed Central

Zhang, Chunhua; Mallery, Eileen; Reagan, Sara; Boyko, Vitaly P.; Kotchoni, Simeon O.; Szymanski, Daniel B.

2013-01-01

During plant cell morphogenesis, signal transduction and cytoskeletal dynamics interact to locally organize the cytoplasm and define the geometry of cell expansion. The WAVE/SCAR (for WASP family verprolin homologous/suppressor of cyclic AMP receptor) regulatory complex (W/SRC) is an evolutionarily conserved heteromeric protein complex. Within the plant kingdom W/SRC is a broadly used effector that converts Rho-of-Plants (ROP)/Rac small GTPase signals into Actin-Related Protein2/3 and actin-dependent growth responses. Although the components and biochemistry of the W/SRC pathway are well understood, a basic understanding of how cells partition W/SRC into active and inactive pools is lacking. In this paper, we report that the endoplasmic reticulum (ER) is an important organelle for W/SRC regulation. We determined that a large intracellular pool of the core W/SRC subunit NAP1, like the known positive regulator of W/SRC, the DOCK family guanine nucleotide-exchange factor SPIKE1 (SPK1), localizes to the surface of the ER. The ER-associated NAP1 is inactive because it displays little colocalization with the actin network, and ER localization requires neither activating signals from SPK1 nor a physical association with its W/SRC-binding partner, SRA1. Our results indicate that in Arabidopsis (Arabidopsis thaliana) leaf pavement cells and trichomes, the ER is a reservoir for W/SRC signaling and may have a key role in the early steps of W/SRC assembly and/or activation. PMID:23613272

Identification and subcellular localization of porcine deltacoronavirus accessory protein NS6

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fang, Puxian; Fang, Liurong; Liu, Xiaorong

Porcine deltacoronavirus (PDCoV) is an emerging swine enteric coronavirus. Accessory proteins are genus-specific for coronavirus, and two putative accessory proteins, NS6 and NS7, are predicted to be encoded by PDCoV; however, this remains to be confirmed experimentally. Here, we identified the leader-body junction sites of NS6 subgenomic RNA (sgRNA) and found that the actual transcription regulatory sequence (TRS) utilized by NS6 is non-canonical and is located upstream of the predicted TRS. Using the purified NS6 from an Escherichia coli expression system, we obtained two anti-NS6 monoclonal antibodies that could detect the predicted NS6 in cells infected with PDCoV or transfectedmore » with NS6-expressing plasmids. Further studies revealed that NS6 is always localized in the cytoplasm of PDCoV-infected cells, mainly co-localizing with the endoplasmic reticulum (ER) and ER-Golgi intermediate compartments, as well as partially with the Golgi apparatus. Together, our results identify the NS6 sgRNA and demonstrate its expression in PDCoV-infected cells. -- Highlights: •The leader-body fusion site of NS6 sgRNA is identified. •NS6 sgRNA uses a non-canonical transcription regulatory sequence (TRS). •NS6 can be expressed in PDCoV-infected cell. •NS6 predominantly localize to the ER complex and ER-Golgi intermediate compartment.« less

77 FR 6553 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER12-525-001. [[Page 6554

ER phospholipid composition modulates lipogenesis during feeding and in obesity.

PubMed

Rong, Xin; Wang, Bo; Palladino, Elisa Nd; de Aguiar Vallim, Thomas Q; Ford, David A; Tontonoz, Peter

2017-10-02

Sterol regulatory element-binding protein 1c (SREBP-1c) is a central regulator of lipogenesis whose activity is controlled by proteolytic cleavage. The metabolic factors that affect its processing are incompletely understood. Here, we show that dynamic changes in the acyl chain composition of ER phospholipids affect SREBP-1c maturation in physiology and disease. The abundance of polyunsaturated phosphatidylcholine in liver ER is selectively increased in response to feeding and in the setting of obesity-linked insulin resistance. Exogenous delivery of polyunsaturated phosphatidylcholine to ER accelerated SREBP-1c processing through a mechanism that required an intact SREBP cleavage-activating protein (SCAP) pathway. Furthermore, induction of the phospholipid-remodeling enzyme LPCAT3 in response to liver X receptor (LXR) activation promoted SREBP-1c processing by driving the incorporation of polyunsaturated fatty acids into ER. Conversely, LPCAT3 deficiency increased membrane saturation, reduced nuclear SREBP-1c abundance, and blunted the lipogenic response to feeding, LXR agonist treatment, or obesity-linked insulin resistance. Desaturation of the ER membrane may serve as an auxiliary signal of the fed state that promotes lipid synthesis in response to nutrient availability.

Unfolded protein response in filamentous fungi-implications in biotechnology.

PubMed

Heimel, Kai

2015-01-01

The unfolded protein response (UPR) represents a mechanism to preserve endoplasmic reticulum (ER) homeostasis that is conserved in eukaryotes. ER stress caused by the accumulation of potentially toxic un- or misfolded proteins in the ER triggers UPR activation and the induction of genes important for protein folding in the ER, ER expansion, and transport from and to the ER. Along with this adaptation, the overall capacity for protein secretion is markedly increased by the UPR. In filamentous fungi, various approaches to employ the UPR for improved production of homologous and heterologous proteins have been investigated. As the effects on protein production were strongly dependent on the expressed protein, generally applicable strategies have to be developed. A combination of transcriptomic approaches monitoring secretion stress and basic research on the UPR mechanism provided novel and important insight into the complex regulatory cross-connections between UPR signalling, cellular physiology, and developmental processes. It will be discussed how this increasing knowledge on the UPR might stimulate the development of novel strategies for using the UPR as a tool in biotechnology.

Interaction mode between catalytic and regulatory subunits in glucosidase II involved in ER glycoprotein quality control.

PubMed

Satoh, Tadashi; Toshimori, Takayasu; Noda, Masanori; Uchiyama, Susumu; Kato, Koichi

2016-11-01

The glycoside hydrolase family 31 (GH31) α-glucosidases play vital roles in catabolic and regulated degradation, including the α-subunit of glucosidase II (GIIα), which catalyzes trimming of the terminal glucose residues of N-glycan in glycoprotein processing coupled with quality control in the endoplasmic reticulum (ER). Among the known GH31 enzymes, only GIIα functions with its binding partner, regulatory β-subunit (GIIβ), which harbors a lectin domain for substrate recognition. Although the structural data have been reported for GIIα and the GIIβ lectin domain, the interaction mode between GIIα and GIIβ remains unknown. Here, we determined the structure of a complex formed between GIIα and the GIIα-binding domain of GIIβ, thereby providing a structural basis underlying the functional extension of this unique GH31 enzyme. © 2016 The Protein Society.

Estrogen receptor of primary breast cancers: evidence for intracellular proteolysis.

PubMed

Maaroufi, Y; Lacroix, M; Lespagnard, L; Journé, F; Larsimont, D; Leclercq, G

2000-01-01

Iodinated oestradiol-labeled oestrogen receptor (ER) isoforms devoid of amino-terminal ABC domains represent about two-thirds of the whole receptor population detected in cytosol samples from human breast cancers. This high frequency could not be ascribed to the expression of truncated mRNAs, or to the proteolysis of the native ER peptide at the time of homogenization or assay, suggesting an intracellular proteolysis. Free amino-terminal and ligand-binding domains maintained together within oligomeric structure(s); increase of ionic strength separated them. The amino-terminal region was consistently detected in the cell nucleus by specific immunohistochemistry leading to the concept of a potential intranuclear association between ER cleavage products and/or other regulatory proteins.

Novel Roles of the Non-catalytic Elements of Yeast Protein-disulfide Isomerase in Its Interplay with Endoplasmic Reticulum Oxidoreductin 1*

PubMed Central

Niu, Yingbo; Zhang, Lihui; Yu, Jiaojiao; Wang, Chih-chen; Wang, Lei

2016-01-01

The formation of disulfide bonds in the endoplasmic reticulum (ER) of eukaryotic cells is catalyzed by the sulfhydryl oxidase, ER oxidoreductin 1 (Ero1), and protein-disulfide isomerase (PDI). PDI is oxidized by Ero1 to continuously introduce disulfides into substrates, and feedback regulates Ero1 activity by manipulating the regulatory disulfides of Ero1. In this study we find that yeast Ero1p is enzymatically active even with its regulatory disulfides intact, and further activation of Ero1p by reduction of the regulatory disulfides requires the reduction of non-catalytic Cys90-Cys97 disulfide in Pdi1p. The principal client-binding site in the Pdi1p b′ domain is necessary not only for the functional Ero1p-Pdi1p disulfide relay but also for the activation of Ero1p. We also demonstrate by complementary activation assays that the regulatory disulfides in Ero1p are much more stable than those in human Ero1α. These new findings on yeast Ero1p-Pdi1p interplay reveal significant differences from our previously identified mode of human Ero1α-PDI interplay and provide insights into the evolution of the eukaryotic oxidative protein folding pathway. PMID:26846856

ER Consolidated Qtrly Rpt_July-September 2015_January 2016

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cochran, John R.

2016-01-01

This Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) provides the status of ongoing corrective action activities being implemented by Sandia National Laboratories, New Mexico (SNL/NM) for the July, August, and September 2015 quarterly reporting period. The Solid Waste Management Units (SWMUs) and Areas of Concern (AOCs) identified for corrective action at SNL/NM are listed in Table I-1. The work completed during this quarter is reported below in Sections I.2.1 and I.2.2. Section I.2.1 summarizes the quarterly activities at sites undergoing corrective action field activities (SWMUs 8 and 58, 68, 149, 154, and 502, and three groundwater AOCs).more » Section I.2.2 summarizes quarterly activities at sites where the New Mexico Environment Department (NMED) has issued a certificate of completion and the site is in the corrective action complete (CAC) regulatory process. Currently, the Mixed Waste Landfill (MWL, SWMU 76) is the only site in the CAC regulatory process. Corrective action activities have been deferred at the Long Sled Track (SWMU 83), the Gun Facilities (SWMU 84), and the Short Sled Track (SWMU 240) because these are active mission facilities.« less

Membrane Contact Sites: Complex Zones for Membrane Association and Lipid Exchange

PubMed Central

Quon, Evan; Beh, Christopher T.

2015-01-01

Lipid transport between membranes within cells involves vesicle and protein carriers, but as agents of nonvesicular lipid transfer, the role of membrane contact sites has received increasing attention. As zones for lipid metabolism and exchange, various membrane contact sites mediate direct associations between different organelles. In particular, membrane contact sites linking the plasma membrane (PM) and the endoplasmic reticulum (ER) represent important regulators of lipid and ion transfer. In yeast, cortical ER is stapled to the PM through membrane-tethering proteins, which establish a direct connection between the membranes. In this review, we consider passive and facilitated models for lipid transfer at PM–ER contact sites. Besides the tethering proteins, we examine the roles of an additional repertoire of lipid and protein regulators that prime and propagate PM–ER membrane association. We conclude that instead of being simple mediators of membrane association, regulatory components of membrane contact sites have complex and multilayered functions. PMID:26949334

An eight-week mindfulness-based stress reduction (MBSR) workshop increases regulatory choice flexibility.

PubMed

Alkoby, Alon; Pliskin, Ruthie; Halperin, Eran; Levit-Binnun, Nava

2018-06-28

Individuals encounter a variety of emotional challenges daily, with optimal emotion modulation requiring adaptive choice among available means of regulation. However, individuals differ in the ability to flexibly and adaptively move between engaging and disengaging emotion regulation (ER) strategies as per contextual demands, referred to as regulatory choice flexibility. Greater regulatory choice flexibility is associated with greater mental health, well-being and resilience, warranting the development of interventions to increase such flexibility. We hypothesized that a mindfulness-based stress reduction (MBSR) program would fulfill this goal. To test our hypothesis, we recruited college students to either participate in an 8-week MBSR workshop or join a waiting list for a later workshop (i.e., control participants). After the workshop's completion, all participants were invited to the laboratory and completed several computerized tasks examining their regulatory choice flexibility when exposed to universally emotion-laden stimuli as well as stimuli specifically related to the students' social and political environment. The regulatory choice patterns of participants who underwent MBSR training were found to be more flexible than those of participants who had not yet completed the workshop, with the former more likely than the latter to favor an engaging ER strategy (i.e., reappraisal) when faced with low-intensity stimuli and a disengaging strategy (i.e., distraction) when faced with high-intensity stimuli. The findings' importance is discussed. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

The Benefits and Limitations of Hydraulic Modeling for Ordinary High Water Mark Delineation

DTIC Science & Technology

2016-02-01

ER D C/ CR RE L TR -1 6- 1 Wetland Regulatory Assistance Program (WRAP) The Benefits and Limitations of Hydraulic Modeling for Ordinary...client/default. Wetland Regulatory Assistance Program (WRAP) ERDC/CRREL TR-16-1 February 2016 The Benefits and Limitations of Hydraulic Modeling...Approved for public release; distribution is unlimited. Prepared for Headquarters, U.S. Army Corps of Engineers Washington, DC 20314-1000 Under Wetlands

Social-cognitive, physiological, and neural mechanisms underlying emotion regulation impairments: Understanding anxiety in autism spectrum disorder

PubMed Central

White, Susan W.; Mazefsky, Carla A.; Dichter, Gabriel S.; Chiu, Pearl H.; Richey, John A.; Ollendick, Thomas H.

2014-01-01

Anxiety is one of the most common clinical problems among children, adolescents, and adults with autism spectrum disorder (ASD), yet we know little about its etiology in the context of ASD. We posit that emotion regulation (ER) impairments are a risk factor for anxiety in ASD. Specifically, we propose that one reason why anxiety disorders are so frequently comorbid with ASD is because ER impairments are ubiquitous to ASD, stemming from socio-cognitive, physiological, and neurological processes related to impaired cognitive control, regulatory processes, and arousal. In this review, we offer a developmental model of how ER impairments may arise in ASD, and when (moderating influences) and how (meditational mechanisms) they result in anxiety. PMID:24951837

Role for Human Mediator Subunit MED25 in Recruitment of Mediator to Promoters by Endoplasmic Reticulum Stress-responsive Transcription Factor ATF6α*

PubMed Central

Sela, Dotan; Conkright, Juliana J.; Chen, Lu; Gilmore, Joshua; Washburn, Michael P.; Florens, Laurence; Conaway, Ronald C.; Conaway, Joan Weliky

2013-01-01

Transcription factor ATF6α functions as a master regulator of endoplasmic reticulum (ER) stress response genes. In response to ER stress, ATF6α translocates from its site of latency in the ER membrane to the nucleus, where it activates RNA polymerase II transcription of ER stress response genes upon binding sequence-specifically to ER stress response enhancer elements (ERSEs) in their promoter-regulatory regions. In a recent study, we demonstrated that ATF6α activates transcription of ER stress response genes by a mechanism involving recruitment to ERSEs of the multisubunit Mediator and several histone acetyltransferase (HAT) complexes, including Spt-Ada-Gcn5 (SAGA) and Ada-Two-A-containing (ATAC) (Sela, D., Chen, L., Martin-Brown, S., Washburn, M.P., Florens, L., Conaway, J.W., and Conaway, R.C. (2012) J. Biol. Chem. 287, 23035–23045). In this study, we extend our investigation of the mechanism by which ATF6α supports recruitment of Mediator to ER stress response genes. We present findings arguing that Mediator subunit MED25 plays a critical role in this process and identify a MED25 domain that serves as a docking site on Mediator for the ATF6α transcription activation domain. PMID:23864652

INTER-REGULATION OF THE UNFOLDED PROTEIN RESPONSE AND AUXIN SIGNALING

PubMed Central

Chen, Yani; Aung, Kyaw; Rolčík, Jakub; Walicki, Kathryn; Friml, Jiří; Brandizzi, Federica

2013-01-01

SUMMARY The unfolded protein response (UPR) is a signaling network triggered by overload of protein-folding demand in the endoplasmic reticulum (ER), a condition termed ER stress. The UPR is critical for growth and development; nonetheless, connections between the UPR and other cellular regulatory processes remain largely unknown. Here, we identify a link between the UPR and the phytohormone auxin, a master regulator of plant physiology. We show that ER stress triggers down-regulation of auxin sensors and transporters in Arabidopsis thaliana. We also demonstrate that an Arabidopsis mutant of a conserved ER stress sensor IRE1 exhibits defects in the auxin response and levels. These data not only support that the plant IRE1 is required for auxin homeostasis, they also reveal a species-specific feature of IRE1 in multicellular eukaryotes. Furthermore, by establishing that UPR activation is reduced in mutants of ER-localized auxin transporters, including PIN5, we define a long-neglected biological significance of ER-based auxin regulation. We further examine the functional relationship of IRE1 and PIN5 by showing that an ire1 pin5 triple mutant enhances defects of UPR activation and auxin homeostasis in ire1 or pin5. Our results imply that the plant UPR has evolved a hormone-dependent strategy for coordinating ER function with physiological processes. PMID:24180465

Task Inventory Construction

DTIC Science & Technology

1976-06-01

clay coo candy chance clean(er) cook(ed) cane change clear cook(ing) cannon chap clerk cooky (ie)(s) cannot charge clever cool(er) canoe charm...deck donkey deed don’t deep door deer doorbell defeat doorknob defend doorstep defense dope delight dot den double dough dove down

High-mobility group (HMG) protein HMG-1 and TATA-binding protein-associated factor TAF(II)30 affect estrogen receptor-mediated transcriptional activation.

PubMed

Verrier, C S; Roodi, N; Yee, C J; Bailey, L R; Jensen, R A; Bustin, M; Parl, F F

1997-07-01

The estrogen receptor (ER) belongs to a family of ligand-inducible nuclear receptors that exert their effects by binding to cis-acting DNA elements in the regulatory region of target genes. The detailed mechanisms by which ER interacts with the estrogen response element (ERE) and affects transcription still remain to be elucidated. To study the ER-ERE interaction and transcription initiation, we employed purified recombinant ER expressed in both the baculovirus-Sf9 and his-tagged bacterial systems. The effect of high-mobility group (HMG) protein HMG-1 and purified recombinant TATA-binding protein-associated factor TAF(II)30 on ER-ERE binding and transcription initiation were assessed by electrophoretic mobility shift assay and in vitro transcription from an ERE-containing template (pERE2LovTATA), respectively. We find that purified, recombinant ER fails to bind to ERE in spite of high ligand-binding activity and electrophoretic and immunological properties identical to ER in MCF-7 breast cancer cells. HMG-1 interacts with ER and promotes ER-ERE binding in a concentration- and time-dependent manner. The effectiveness of HMG-1 to stimulate ER-ERE binding in the electrophoretic mobility shift assay depends on the sequence flanking the ERE consensus as well as the position of the latter in the oligonucleotide. We find that TAF(II)30 has no effect on ER-ERE binding either alone or in combination with ER and HMG-1. Although HMG-1 promotes ER-ERE binding, it fails to stimulate transcription initiation either in the presence or absence of hormone. In contrast, TAF(II)30, while not affecting ER-ERE binding, stimulates transcription initiation 20-fold in the presence of HMG-1. These results indicate that HMG-1 and TAF(II)30 act in sequence, the former acting to promote ER-ERE binding followed by the latter to stimulate transcription initiation.

77 FR 56829 - Combined Notice of Filings #2

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2012-09-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER12-1942-000. Applicants: Midwest Independent Transmission System Operator, Inc. Description: Midwest Independent...

76 FR 26282 - NRG Solar Roadrunner LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

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2011-05-06

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3459-000] NRG Solar Roadrunner LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... 26283

23 CFR 668.105 - Policy.

Code of Federal Regulations, 2011 CFR

2011-04-01

... aid States in repairing road facilities which have suffered widespread serious damage resulting from a... feasible, the cost of permanent restoration work. (d) The approval to use available ER funds to repair or... over non-emergency work. (h) ER projects shall be promptly constructed. Any project that has not...

Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ji, Quanjiang; Chen, Peter J.; Qin, Guangrong

Most low GC Gram-positive bacteria possess an essential walKR two-component system (TCS) for signal transduction involved in regulating cell wall homoeostasis. Despite the well-established intracellular regulatory mechanism, the role of this TCS in extracellular signal recognition and factors that modulate the activity of this TCS remain largely unknown. Here we identify the extracellular receptor of the kinase ‘WalK’ (erWalK) as a key hub for bridging extracellular signal input and intracellular kinase activity modulation in Staphylococcus aureus. Characterization of the crystal structure of erWalK revealed a canonical Per-Arnt-Sim (PAS) domain for signal sensing. Single amino-acid mutation of potential signal-transduction residues resultedmore » in severely impaired function of WalKR. A small molecule derived from structure-based virtual screening against erWalK is capable of selectively activating the walKR TCS. Lastly, the molecular level characterization of erWalK will not only facilitate exploration of natural signal(s) but also provide a template for rational design of erWalK inhibitors.« less

Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus

DOE PAGES

Ji, Quanjiang; Chen, Peter J.; Qin, Guangrong; ...

2016-03-18

Most low GC Gram-positive bacteria possess an essential walKR two-component system (TCS) for signal transduction involved in regulating cell wall homoeostasis. Despite the well-established intracellular regulatory mechanism, the role of this TCS in extracellular signal recognition and factors that modulate the activity of this TCS remain largely unknown. Here we identify the extracellular receptor of the kinase ‘WalK’ (erWalK) as a key hub for bridging extracellular signal input and intracellular kinase activity modulation in Staphylococcus aureus. Characterization of the crystal structure of erWalK revealed a canonical Per-Arnt-Sim (PAS) domain for signal sensing. Single amino-acid mutation of potential signal-transduction residues resultedmore » in severely impaired function of WalKR. A small molecule derived from structure-based virtual screening against erWalK is capable of selectively activating the walKR TCS. Lastly, the molecular level characterization of erWalK will not only facilitate exploration of natural signal(s) but also provide a template for rational design of erWalK inhibitors.« less

Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

PubMed Central

Infante, Rodney Elwood; Radhakrishnan, Arun

2017-01-01

Cells employ regulated transport mechanisms to ensure that their plasma membranes (PMs) are optimally supplied with cholesterol derived from uptake of low-density lipoproteins (LDL) and synthesis. To date, all inhibitors of cholesterol transport block steps in lysosomes, limiting our understanding of post-lysosomal transport steps. Here, we establish the cholesterol-binding domain 4 of anthrolysin O (ALOD4) as a reversible inhibitor of cholesterol transport from PM to endoplasmic reticulum (ER). Using ALOD4, we: (1) deplete ER cholesterol without altering PM or overall cellular cholesterol levels; (2) demonstrate that LDL-derived cholesterol travels from lysosomes first to PM to meet cholesterol needs, and subsequently from PM to regulatory domains of ER to suppress activation of SREBPs, halting cholesterol uptake and synthesis; and (3) determine that continuous PM-to-ER cholesterol transport allows ER to constantly monitor PM cholesterol levels, and respond rapidly to small declines in cellular cholesterol by activating SREBPs, increasing cholesterol uptake and synthesis. DOI: http://dx.doi.org/10.7554/eLife.25466.001 PMID:28414269

77 FR 53882 - Combined Notice of Filings #2

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2012-09-04

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Environmental Restoration (ER) Consolidated Quarterly Report_April to June 2017_ October 2017

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cochran, John R.

2017-10-01

This Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) provides the status of ongoing corrective action activities being implemented at Sandia National Laboratories, New Mexico (SNL/NM) during the April, May, and June 2017 quarterly reporting period. Table I-1 lists the Solid Waste Management Units (SWMUs) and Areas of Concern (AOCs) identified for corrective action at SNL/NM. Sections I.2.1 and I.2.2 summarize the work completed during this quarter. Section I.2.1 summarizes the quarterly activities at sites undergoing corrective action field activities. Field activities are conducted at the three groundwater AOCs (Burn Site Groundwater [BSG AOC], Technical Area [TA]-V Groundwatermore » [TAVG AOC], and Tijeras Arroyo Groundwater [TAG AOC]). Section I.2.2 summarizes quarterly activities at sites where the New Mexico Environment Department (NMED) Hazardous Waste Bureau (HWB) issued a certificate of completion and the sites are in the corrective action complete (CAC) regulatory process. Currently, SWMUs 8 and 58, 68, 149, 154, and 502 are in the CAC regulatory process. Corrective action activities are deferred at the Long Sled Track (SWMU 83), the Gun Facilities (SWMU 84), and the Short Sled Track (SWMU 240) because these three sites are active mission facilities. These three active mission sites are located in TA-III.« less

Environmental Restoration Operations: Consolidated Quarterly Report January -March 2017

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cochran, John R.

This Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) provides the status of ongoing corrective action activities being implemented at Sandia National Laboratories, New Mexico (SNL/NM) during the January, February, and March 2017 quarterly reporting period. Table I-1 lists the Solid Waste Management Units (SWMUs) and Areas of Concern (AOCs) identified for corrective action at SNL/NM. Sections I.2.1 and I.2.2 summarize the work completed during this quarter. Section I.2.1 summarizes the quarterly activities at sites undergoing corrective action field activities. Field activities are conducted at the three groundwater AOCs (Burn Site Groundwater [BSG AOC], Technical Area [TA]-V Groundwatermore » [TAVG AOC], and Tijeras Arroyo Groundwater [TAG AOC]). Section I.2.2 summarizes quarterly activities at sites where the New Mexico Environment Department (NMED) Hazardous Waste Bureau (HWB) issued a certificate of completion and the sites are in the corrective action complete (CAC) regulatory process. Currently, SWMUs 8 and 58, 68, 149, 154, and 502 are in the CAC regulatory process. Corrective action activities are deferred at the Long Sled Track (SWMU 83), the Gun Facilities (SWMU 84), and the Short Sled Track (SWMU 240) because these three sites are active mission facilities. These three active mission sites are located in TA-III. This Sandia National Laboratories, New Mexico Environmental Restoration Operations (ER) Consolidated Quarterly Report (ER Quarterly Report) fulfills all quarterly reporting requirements set forth in the Resource Conservation and Recovery Act Facility Operating Permit and the Compliance Order on Consent.« less

Maternal emotion regulation during child distress, child anxiety accommodation, and links between maternal and child anxiety.

PubMed

Kerns, Caroline E; Pincus, Donna B; McLaughlin, Katie A; Comer, Jonathan S

2017-08-01

Environmental contributions are thought to play a primary role in the familial aggregation of anxiety, but parenting influences remain poorly understood. We examined dynamic relations between maternal anxiety, maternal emotion regulation (ER) during child distress, maternal accommodation of child distress, and child anxiety. Mothers (N=45) of youth ages 3-8 years (M=4.8) participated in an experimental task during which they listened to a standardized audio recording of a child in anxious distress pleading for parental intervention. Measures of maternal and child anxiety, mothers' affective states, mothers' ER strategies during the child distress, and maternal accommodation of child anxiety were collected. Mothers' resting respiratory sinus arrhythmia (RSA) reactivity during the recording was also acquired. Higher maternal negative affect and greater maternal ER switching (i.e., using multiple ER strategies in a short time without positive regulatory results) during child distress were associated with child anxiety. Sequential mediation modeling showed that maternal anxiety predicted ineffective maternal ER during child distress exposure, which in turn predicted greater maternal accommodation, which in turn predicted higher child anxiety. Findings support the mediating roles of maternal ER and accommodation in linking maternal and child anxiety, and suggest that ineffective maternal ER and subsequent attempts to accommodate child distress may act as mechanisms underlying the familial aggregation of anxiety. Copyright © 2017 Elsevier Ltd. All rights reserved.

77 FR 31608 - Combined Notice of Filings #1

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2012-05-29

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The indirect effect of panic disorder on smoking cognitions via difficulties in emotion regulation.

PubMed

Yang, Min-Jeong; Zvolensky, Michael J; Leyro, Teresa M

2017-09-01

Panic disorder (PD) and cigarette smoking are highly comorbid and associated with worse panic and smoking outcomes. Smoking may become an overlearned automatized response to relieve panic-like withdrawal distress, leading to corresponding smoking cognitions, which contribute to its reinforcing properties and difficultly abstaining. Difficulties in emotion regulation (ER) may underlie this relation such that in the absence of adaptive emotion regulatory strategies, smokers with PD may more readily rely upon smoking to manage affective distress. In the current study, the indirect relation between PD status and smoking cognitions through ER difficulties was examined among daily smokers (N=74). We found evidence for an indirect relation between PD status and negative affect, addictive and habitual smoking motives, and anticipating smoking will result in negative reinforcement and personal harm, through self-reported difficulties with ER. Our findings are aligned with theoretical models on anxiety and smoking, and suggest that reports of greater smoking cognitions may be due to ER difficulties. Copyright © 2017. Published by Elsevier Ltd.

USP19-Mediated Deubiquitination Facilitates the Stabilization of HRD1 Ubiquitin Ligase.

PubMed

Harada, Kumi; Kato, Masako; Nakamura, Nobuhiro

2016-11-02

In the endoplasmic reticulum (ER), misfolded and unfolded proteins are eliminated by a process called ER-associated protein degradation (ERAD) in order to maintain cell homeostasis. In the ERAD pathway, several ER-localized E3 ubiquitin ligases target ERAD substrate proteins for ubiquitination and subsequent proteasomal degradation. However, little is known about how the functions of the ERAD ubiquitin ligases are regulated. Recently, USP19, an ER-anchored deubiquitinating enzyme (DUB), has been suggested to be involved in the regulation of ERAD. In this study, HRD1, an ERAD ubiquitin ligase, is shown to be a novel substrate for USP19. We demonstrate that USP19 rescues HRD1 from proteasomal degradation by deubiquitination of K48-linked ubiquitin chains. In addition, the altered expression of USP19 affects the steady-state levels of HRD1. These results suggest that USP19 regulates the stability of HRD1 and provide insight into the regulatory mechanism of the ERAD ubiquitin ligases.

mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells.

PubMed

Eid, Walaa; Dauner, Kristin; Courtney, Kevin C; Gagnon, AnneMarie; Parks, Robin J; Sorisky, Alexander; Zha, Xiaohui

2017-07-25

mTORC1 is known to activate sterol regulatory element-binding proteins (SREBPs) including SREBP-2, a master regulator of cholesterol synthesis. Through incompletely understood mechanisms, activated mTORC1 triggers translocation of SREBP-2, an endoplasmic reticulum (ER) resident protein, to the Golgi where SREBP-2 is cleaved to translocate to the nucleus and activate gene expression for cholesterol synthesis. Low ER cholesterol is a well-established trigger for SREBP-2 activation. We thus investigated whether mTORC1 activates SREBP-2 by reducing cholesterol delivery to the ER. We report here that mTORC1 activation is accompanied by low ER cholesterol and an increase of SREBP-2 activation. Conversely, a decrease in mTORC1 activity coincides with a rise in ER cholesterol and a decrease in SERBP-2 activity. This rise in ER cholesterol is of lysosomal origin: blocking the exit of cholesterol from lysosomes by U18666A or NPC1 siRNA prevents ER cholesterol from increasing and, consequently, SREBP-2 is activated without mTORC1 activation. Furthermore, when mTORC1 activity is low, cholesterol is delivered to lysosomes through two membrane trafficking pathways: autophagy and rerouting of endosomes to lysosomes. Indeed, with dual blockade of both pathways by Atg5 -/- and dominant-negative rab5, ER cholesterol fails to increase when mTORC1 activity is low, and SREBP-2 is activated. Conversely, overexpressing constitutively active Atg7, which forces autophagy and raises ER cholesterol even when mTORC1 activity is high, suppresses SREBP-2 activation. We conclude that mTORC1 actively suppresses autophagy and maintains endosomal recycling, thereby preventing endosomes and autophagosomes from reaching lysosomes. This results in a reduction of cholesterol in the ER and activation of SREBP-2.

Endoplasmic reticulum stress-responsive transcription factor ATF6α directs recruitment of the Mediator of RNA polymerase II transcription and multiple histone acetyltransferase complexes.

PubMed

Sela, Dotan; Chen, Lu; Martin-Brown, Skylar; Washburn, Michael P; Florens, Laurence; Conaway, Joan Weliky; Conaway, Ronald C

2012-06-29

The basic leucine zipper transcription factor ATF6α functions as a master regulator of endoplasmic reticulum (ER) stress response genes. Previous studies have established that, in response to ER stress, ATF6α translocates to the nucleus and activates transcription of ER stress response genes upon binding sequence specifically to ER stress response enhancer elements in their promoters. In this study, we investigate the biochemical mechanism by which ATF6α activates transcription. By exploiting a combination of biochemical and multidimensional protein identification technology-based mass spectrometry approaches, we have obtained evidence that ATF6α functions at least in part by recruiting to the ER stress response enhancer elements of ER stress response genes a collection of RNA polymerase II coregulatory complexes, including the Mediator and multiple histone acetyltransferase complexes, among which are the Spt-Ada-Gcn5 acetyltransferase (SAGA) and Ada-Two-A-containing (ATAC) complexes. Our findings shed new light on the mechanism of action of ATF6α, and they outline a straightforward strategy for applying multidimensional protein identification technology mass spectrometry to determine which RNA polymerase II transcription factors and coregulators are recruited to promoters and other regulatory elements to control transcription.

Eucommia ulmoides Oliver Extract, Aucubin, and Geniposide Enhance Lysosomal Activity to Regulate ER Stress and Hepatic Lipid Accumulation

PubMed Central

Lee, Hwa-Young; Lee, Geum-Hwa; Lee, Mi-Rin; Kim, Hye-Kyung; Kim, Nan-young; Kim, Seung-Hyun; Lee, Yong-Chul; Kim, Hyung-Ryong; Chae, Han-Jung

2013-01-01

Eucommia ulmoides Oliver is a natural product widely used as a dietary supplement and medicinal plant. Here, we examined the potential regulatory effects of Eucommia ulmoides Oliver extracts (EUE) on hepatic dyslipidemia and its related mechanisms by in vitro and in vivo studies. EUE and its two active constituents, aucubin and geniposide, inhibited palmitate-induced endoplasmic reticulum (ER) stress, reducing hepatic lipid accumulation through secretion of apolipoprotein B and associated triglycerides and cholesterol in human HepG2 hepatocytes. To determine how EUE diminishes the ER stress response, lysosomal and proteasomal protein degradation activities were analyzed. Although proteasomal activity was not affected, lysosomal enzyme activities including V-ATPase were significantly increased by EUE as well as aucubin and geniposide in HepG2 cells. Treatment with the V-ATPase inhibitor, bafilomycin, reversed the inhibition of ER stress, secretion of apolipoprotein B, and hepatic lipid accumulation induced by EUE or its component, aucubin or geniposide. In addition, EUE was determined to regulate hepatic dyslipidemia by enhancing lysosomal activity and to regulate ER stress in rats fed a high-fat diet. Together, these results suggest that EUE and its active components enhance lysosomal activity, resulting in decreased ER stress and hepatic dyslipidemia. PMID:24349058

76 FR 53896 - Combined Notice of Filings #1

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2011-08-30

... following electric rate filings: Docket Numbers: ER11-4336-002. Applicants: ISO New England Inc. Description: ISO New England Inc. submits tariff filing per 35.17(b): Errata to Docket No. ER11-4336-001 to be.... submits tariff filing per 35.13(a)(2)(iii): 2233 Osage Wind/GRDA Facilities Construction Agreement to be...

ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2.

PubMed

Kee, Anthony J; Bryce, Nicole S; Yang, Lingyan; Polishchuk, Elena; Schevzov, Galina; Weigert, Roberto; Polishchuk, Roman; Gunning, Peter W; Hardeman, Edna C

2017-10-01

We have identified novel actin filaments defined by tropomyosin Tpm4.2 at the ER. EM analysis of mouse embryo fibroblasts (MEFs) isolated from mice expressing a mutant Tpm4.2 (Tpm4 Plt53/Plt53 ), incapable of incorporating into actin filaments, revealed swollen ER structures compared with wild-type (WT) MEFs (Tpm4 +/+ ). ER-to-Golgi, but not Golgi-to-ER trafficking was altered in the Tpm4 Plt53/Plt53 MEFs following the transfection of the temperature sensitive ER-associated ts045-VSVg construct. Exogenous Tpm4.2 was able to rescue the ER-to-Golgi trafficking defect in the Tpm4 Plt53/Plt53 cells. The treatment of WT MEFs with the myosin II inhibitor, blebbistatin, blocked the Tpm4.2-dependent ER-to-Golgi trafficking. The lack of an effect on ER-to-Golgi trafficking following treatment of MEFs with CK666 indicates that branched Arp2/3-containing actin filaments are not involved in anterograde vesicle trafficking. We propose that unbranched, Tpm4.2-containing filaments have an important role in maintaining ER/Golgi structure and that these structures, in conjunction with myosin II motors, mediate ER-to-Golgi trafficking. © 2017 Wiley Periodicals, Inc.

Synergism between a half-site and an imperfect estrogen-responsive element, and cooperation with COUP-TFI are required for estrogen receptor (ER) to achieve a maximal estrogen-stimulation of rainbow trout ER gene.

PubMed

Petit, F G; Métivier, R; Valotaire, Y; Pakdel, F

1999-01-01

In all oviparous, liver represents one of the main E2-target tissues where estrogen receptor (ER) constitutes the key mediator of estrogen action. The rainbow trout estrogen receptor (rtER) gene expression is markedly up-regulated by estrogens and the sequences responsible for this autoregulation have been located in a 0.2 kb upstream transcription start site within - 40/- 248 enhancer region. Absence of interference with steroid hormone receptors and tissue-specific factors and a conserved basal transcriptional machinery between yeast and higher eukaryotes, make yeast a simple assay system that will enable determination of important cis-acting regulatory sequences within rtER gene promoter and identification of transcription factors implicated in the regulation of this gene. Deletion analysis allowed to show a synergistic effect between an imperfect estrogen-responsive element (ERE) and a consensus half-ERE to achieve a high hormone-dependent transcriptional activation of the rtER gene promoter in the presence of stably expressed rtER. As in mammalian cells, here we observed a positive regulation of the rtER gene promoter by the chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) through enhancing autoregulation. Using a point mutation COUP-TFI mutant unable to bind DNA demonstrates that enhancement of rtER gene autoregulation requires the interaction of COUP-TFI to the DNA. Moreover, this enhancement of transcriptional activation by COUP-TFI requires specifically the AF-1 transactivation function of ER and can be observed in the presence of E2 or 4-hydroxytamoxifen but not ICI 164384. Thus, this paper describes the reconstitution of a hormone-responsive transcription unit in yeast in which the regulation of rtER gene promoter could be enhanced by the participation of cis-elements and/or trans-acting factors, such as ER itself or COUP-TF.

78 FR 43195 - Combined Notice of Filings #1

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2013-07-19

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The SANT domain of human MI-ER1 interacts with Sp1 to interfere with GC box recognition and repress transcription from its own promoter.

PubMed

Ding, Zhihu; Gillespie, Laura L; Mercer, F Corinne; Paterno, Gary D

2004-07-02

To gain insight into the regulation of hmi-er1 expression, we cloned a human genomic DNA fragment containing one of the two hmi-er1 promoters and consisting of 1460 bp upstream of the translation initiation codon of hMI-ER1. Computer-assisted sequence analysis revealed that the hmi-er1 promoter region contains a CpG island but lacks an identifiable TATA element, initiator sequence and downstream promoter element. This genomic DNA was able to direct transcription of a luciferase reporter gene in a variety of human cell lines, and the minimal promoter was shown to be located within-68/+144 bp. Several putative Sp1 binding sites were identified, and we show that Sp1 can bind to the hmi-er1 minimal promoter and increase transcription, suggesting that the level of hmi-er1 expression may depend on the availability of Sp1 protein. Functional analysis revealed that hMI-ER1 represses Sp1-activated transcription from the minimal promoter by a histone deacetylase-independent mechanism. Chromatin immunoprecipitation analysis demonstrated that both Sp1 and hMI-ER1 are associated with the chromatin of the hmi-er1 promoter and that overexpression of hMI-ER1 in cell lines that allow Tet-On-inducible expression resulted in loss of detectable Sp1 from the endogenous hmi-er1 promoter. The mechanism by which this occurs does not involve binding of hMI-ER1 to cis-acting elements. Instead, we show that hMI-ER1 physically associates with Sp1 and that endogenous complexes containing the two proteins could be detected in vivo. Furthermore, hMI-ER1 specifically interferes with binding of Sp1 to the hmi-er1 minimal promoter as well as to an Sp1 consensus oligonucleotide. Deletion analysis revealed that this interaction occurs through a region containing the SANT domain of hMI-ER1. Together, these data reveal a functional role for the SANT domain in the action of co-repressor regulatory factors and suggest that the association of hMI-ER1 with Sp1 represents a novel mechanism for the negative regulation of Sp1 target promoters.

Predicting sugar-sweetened behaviours with theory of planned behaviour constructs: Outcome and process results from the SIPsmartER behavioural intervention.

PubMed

Zoellner, Jamie M; Porter, Kathleen J; Chen, Yvonnes; Hedrick, Valisa E; You, Wen; Hickman, Maja; Estabrooks, Paul A

2017-05-01

Guided by the theory of planned behaviour (TPB) and health literacy concepts, SIPsmartER is a six-month multicomponent intervention effective at improving SSB behaviours. Using SIPsmartER data, this study explores prediction of SSB behavioural intention (BI) and behaviour from TPB constructs using: (1) cross-sectional and prospective models and (2) 11 single-item assessments from interactive voice response (IVR) technology. Quasi-experimental design, including pre- and post-outcome data and repeated-measures process data of 155 intervention participants. Validated multi-item TPB measures, single-item TPB measures, and self-reported SSB behaviours. Hypothesised relationships were investigated using correlation and multiple regression models. TPB constructs explained 32% of the variance cross sectionally and 20% prospectively in BI; and explained 13-20% of variance cross sectionally and 6% prospectively. Single-item scale models were significant, yet explained less variance. All IVR models predicting BI (average 21%, range 6-38%) and behaviour (average 30%, range 6-55%) were significant. Findings are interpreted in the context of other cross-sectional, prospective and experimental TPB health and dietary studies. Findings advance experimental application of the TPB, including understanding constructs at outcome and process time points and applying theory in all intervention development, implementation and evaluation phases.

Simulation Gaming in Construction: ER, The Equipment Replacement Game.

ERIC Educational Resources Information Center

Nassar, Khaled

2002-01-01

The Equipment Replacement simulation game can be used to explain the different effects of various equipment buy/sell strategies on the economic performance of construction companies. The probabilistic aspect of demand in the construction market is incorporated. The game is implemented using Excel and Visual Basic for Applications. (Author/SK)

A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy.

PubMed

Deegan, Shane; Koryga, Izabela; Glynn, Sharon A; Gupta, Sanjeev; Gorman, Adrienne M; Samali, Afshin

2015-01-02

Endoplasmic reticulum (ER) stress is known to lead to activation of both the unfolded protein response (UPR) and autophagy. Although regulatory connections have been identified between the UPR and autophagy, it is still unclear to what extent the UPR regulates the genes involved at the different stages of the autophagy pathway. Here, we carried out a microarray analysis of HCT116 cells subjected to ER stress and observed the transcriptional upregulation of a large cohort of autophagy-related genes. Of particular interest, we identified the transcriptional upregulation of the autophagy receptor genes SQSTM1/p62, NBR1 and BNIP3L/NIX in response to ER stress and show that the inhibition of the UPR transmembrane receptors, PERK and IRE1, abrogates this upregulation. Copyright © 2014 Elsevier Inc. All rights reserved.

Measurement and control of bias in patient reported outcomes using multidimensional item response theory.

PubMed

Dowling, N Maritza; Bolt, Daniel M; Deng, Sien; Li, Chenxi

2016-05-26

Patient-reported outcome (PRO) measures play a key role in the advancement of patient-centered care research. The accuracy of inferences, relevance of predictions, and the true nature of the associations made with PRO data depend on the validity of these measures. Errors inherent to self-report measures can seriously bias the estimation of constructs assessed by the scale. A well-documented disadvantage of self-report measures is their sensitivity to response style (RS) effects such as the respondent's tendency to select the extremes of a rating scale. Although the biasing effect of extreme responding on constructs measured by self-reported tools has been widely acknowledged and studied across disciplines, little attention has been given to the development and systematic application of methodologies to assess and control for this effect in PRO measures. We review the methodological approaches that have been proposed to study extreme RS effects (ERS). We applied a multidimensional item response theory model to simultaneously estimate and correct for the impact of ERS on trait estimation in a PRO instrument. Model estimates were used to study the biasing effects of ERS on sum scores for individuals with the same amount of the targeted trait but different levels of ERS. We evaluated the effect of joint estimation of multiple scales and ERS on trait estimates and demonstrated the biasing effects of ERS on these trait estimates when used as explanatory variables. A four-dimensional model accounting for ERS bias provided a better fit to the response data. Increasing levels of ERS showed bias in total scores as a function of trait estimates. The effect of ERS was greater when the pattern of extreme responding was the same across multiple scales modeled jointly. The estimated item category intercepts provided evidence of content independent category selection. Uncorrected trait estimates used as explanatory variables in prediction models showed downward bias. A comprehensive evaluation of the psychometric quality and soundness of PRO assessment measures should incorporate the study of ERS as a potential nuisance dimension affecting the accuracy and validity of scores and the impact of PRO data in clinical research and decision making.

Endoplasmic reticulum stress in the brain subfornical organ contributes to sex differences in angiotensin-dependent hypertension in rats.

PubMed

Dai, S-Y; Fan, J; Shen, Y; He, J-J; Peng, W

2016-05-01

Endoplasmic reticulum (ER) stress in the brain subfornical organ (SFO), a key cardiovascular regulatory centre, has been implicated in angiotensin (ANG) II-induced hypertension in males; however, the contribution of ER stress to ANG II-induced hypertension in females is unknown. Female hormones have been shown to prevent ER stress in the periphery. We tested the hypothesis that females are less susceptible to ANG II-induced SFO ER stress than males, leading to sex differences in hypertension. Male, intact and ovariectomized (OVX) female rats received a continuous 2-week subcutaneous infusion of ANG II or saline. Additional male, intact and OVX female rats received intracerebroventricular (ICV) injection of ER stress inducer tunicamycin. ANG II, but not saline, increased blood pressure (BP) in both males and females, but intact females exhibited smaller increase in BP and less depressor response to ganglionic blockade compared with males or OVX females. Molecular studies revealed that ANG II elevated expression of ER stress biomarkers and Fra-like activity in the SFO in both males and females; however, elevations in these parameters were less in intact females than in males or OVX females. Moreover, ICV tunicamycin induced smaller elevation in BP and less increase in expression of ER stress biomarkers in the SFO in intact females compared with males or OVX females. The results suggest that differences in ANG II-induced brain ER stress between males and females contribute to sex differences in ANG II-mediated hypertension and that oestrogen protects females against ANG II-induced brain ER stress. © 2015 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.

Performance of the BG1Luc ER TA method in a qHTS format.

PubMed

Ceger, Patricia; Allen, David; Huang, Ruili; Xia, Menghang; Casey, Warren

2015-01-01

In 2012, the BG1Luc4E2 estrogen receptor (ER) transactivation (TA) method (BG1Luc ER TA) was accepted by U.S. regulatory agencies and the Organisation for Economic Co-operation and Development to detect substances with ER agonist activity. The method is now part of the Tier 1 testing battery in the Environmental Protection Agency's Endocrine Disruptor Screening Program. The BG1Luc ER TA method uses the BG1 ovarian cell line that endogenously expresses full-length ER (α and β) and is stably transfected with a plasmid containing four estrogen responsive elements upstream of a luciferase reporter gene. To allow increased throughput and testing efficiency, the BG1Luc ER TA ("BG1 manual") method was adapted for quantitative high-throughput screening (BG1 qHTS) in the U.S. Tox21 testing program. The BG1 qHTS test method was used to test approximately 10,000 chemicals three times each, and concentration-response data (n=15) were analyzed to evaluate test method performance. The balanced accuracy of the BG1 qHTS test method (97% [32/33]) was determined by comparing results to ER TA performance standards for the BG1 manual method. Concordance between the BG1 manual and qHTS methods was 92% (57/62) when calculated for a larger set of non-reference chemicals tested in both methods. These data demonstrate that the performance of the BG1 qHTS is similar to the currently accepted BG1 manual method, thereby establishing the utility of the BG1 qHTS method for identifying ER active environmental chemicals.

Ubiquitin-dependent Protein Degradation at the Yeast Endoplasmic Reticulum and Nuclear Envelope

PubMed Central

Zattas, Dimitrios; Hochstrasser, Mark

2014-01-01

The endoplasmic reticulum (ER) is the primary organelle in eukaryotic cells where membrane and secreted proteins are inserted into or across cell membranes. Its membrane bilayer and luminal compartments provide a favorable environment for the folding and assembly of thousands of newly synthesized proteins. However, protein folding is intrinsically error-prone, and various stress conditions can further increase levels of protein misfolding and damage, particularly in the ER, which can lead to cellular dysfunction and disease. The ubiquitin-proteasome system (UPS) is responsible for the selective destruction of a vast array of protein substrates, either for protein quality control or to allow rapid changes in the levels of specific regulatory proteins. In this review, we will focus on the components and mechanisms of ER-associated protein degradation (ERAD), an important branch of the UPS. ER membranes extend from subcortical regions of the cell to the nuclear envelope, with its continuous outer and inner membranes; the nuclear envelope is a specialized subdomain of the ER. ERAD presents additional challenges to the UPS beyond those faced with soluble substrates of the cytoplasm and nucleus. These include recognition of sugar modifications that occur in the ER, retrotranslocation of proteins across the membrane bilayer, and transfer of substrates from the ER extraction machinery to the proteasome. Here we review characteristics of ERAD substrate degradation signals (degrons), mechanisms underlying substrate recognition and processing by the ERAD machinery, and ideas on the still unresolved problem of how substrate proteins are moved across and extracted from the ER membrane. PMID:25231236

77 FR 59390 - Combined Notice of Filings #1

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2012-09-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER12-2313-001. Applicants: Laurel Hill Wind Energy, LLC. Description: MBR Amendment to be effective 9/10/2012. Filed Date: 9...

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2013-04-30

...- 004; ER12-2496-004. Applicants: Bangor Hydro Electric Company, Emera Energy Services, Inc., Emera.... Description: Notice of Change in Status of Bangor Hydro Electric Company, et al. Filed Date: 4/22/13... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...

76 FR 73610 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-29

.... Comments Due: 5 p.m. ET 12/8/11. Docket Numbers: ER12-432-000. Applicants: Puget Sound Energy, Inc... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice.... Applicants: Ridgeline Alternative Energy, LLC. Description: Joint Application of Ridgeline Alternative Energy...

75 FR 35784 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-23

...: Puget Sound Energy, Inc. Description: Puget Sound Energy, Inc submits an amendment to its Open Access... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 June 15... following electric rate filings: Docket Numbers: ER97-851-021. Applicants: Hydro-Quebec Energy Services (U.S...

Insights on the involvement of (-)-epigallocatechin gallate in ER stress-mediated apoptosis in age-related macular degeneration.

PubMed

Karthikeyan, Bose; Harini, Lakshminarasimhan; Krishnakumar, Vaithilingam; Kannan, Velu Rajesh; Sundar, Krishnan; Kathiresan, Thandavarayan

2017-01-01

Endoplasmic reticulum (ER) stress-mediated apoptosis is a well-known factor in the pathogenesis of age-related macular degeneration (AMD). ER stress leads to accumulation of misfolded proteins, which in turn activates unfolded protein response (UPR) of the cell for its survival. The prolonged UPR of ER stress promotes cell death; however, the transition between adaptation and ER stress-induced apoptosis has not been clearly understood. Hence, the present study investigates the regulatory effect of (-)-epigallocatechin gallate (EGCG) on ER stress-induced by hydrogen peroxide (H 2 O 2 ) and disturbance of calcium homeostasis by thapsigargin (TG) in mouse retinal pigment epithelial (MRPE) cells. The oxidant molecules influenced MRPE cells showed an increased level of intracellular calcium [Ca 2+ ] i in ER and transferred to mitochondria through ER-mitochondrial tether site then increased ROS production. EGCG restores [Ca 2+ ] i homeostasis by decreasing ROS production through inhibition of prohibitin1 which regulate ER-mitochondrial tether site and inhibit apoptosis. Effect of EGCG on ER stress-mediated apoptosis was elucidated by exploring the UPR signalling pathways. EGCG downregulated GRP78, CHOP, PERK, ERO1α, IRE1α, cleaved PARP, cleaved caspase 3, caspase 12 and upregulated expression of calnexinin MRPE cells. In addition to this, inhibition of apoptosis by EGCG was also confirmed with expression of proteins Akt, PTEN and GSK3β. MRPE cells with EGCG upregulates phosphorylation of Akt at ser473 and phospho ser380 of PTEN, but phosphorylation at ser9 of GSK3β was inhibited. Further, constitutively active (myristoylated) CA-Akt transfected in MRPE cells had an increased Akt activity in EGCG influenced cells. These findings strongly suggest that antioxidant molecules inhibit cell death through the proper balancing of [Ca 2+ ] i and ROS production in order to maintain UPR of ER in MRPE cells. Thus, modulation of UPR signalling may provide a potential target for the therapeutic approaches of AMD.

Molecular association of Arabidopsis RTH with its homolog RTE1 in regulating ethylene signaling.

PubMed

Zheng, Fangfang; Cui, Xiankui; Rivarola, Maximo; Gao, Ting; Chang, Caren; Dong, Chun-Hai

2017-05-17

The plant hormone ethylene affects many biological processes during plant growth and development. Ethylene is perceived by ethylene receptors at the endoplasmic reticulum (ER) membrane. The ETR1 ethylene receptor is positively regulated by the transmembrane protein RTE1, which localizes to the ER and Golgi apparatus. The RTE1 gene family is conserved in animals, plants, and lower eukaryotes. In Arabidopsis, RTE1-HOMOLOG (RTH) is the only homolog of the Arabidopsis RTE1 gene family. The regulatory function of the Arabidopsis RTH in ethylene signaling and plant growth is largely unknown. The present study shows Arabidopsis RTH gene expression patterns, protein co-localization with the ER and Golgi apparatus, and the altered ethylene response phenotype when RTH is knocked out or overexpressed in Arabidopsis. Compared with rte1 mutants, rth mutants exhibit less sensitivity to exogenous ethylene, while RTH overexpression confers ethylene hypersensitivity. Genetic analyses indicate that Arabidopsis RTH might not directly regulate the ethylene receptors. RTH can physically interact with RTE1, and evidence supports that RTH might act via RTE1 in regulating ethylene responses and signaling. The present study advances our understanding of the regulatory function of the Arabidopsis RTE1 gene family members in ethylene signaling. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

The penis: a new target and source of estrogen in male reproduction.

PubMed

Mowa, C N; Jesmin, S; Miyauchi, T

2006-01-01

In the past decade, interest and knowledge in the role of estrogen in male reproduction and fertility has gained significant momentum. More recently, the cellular distribution and activity of estrogen receptors (alpha and beta)(ER) and aromatase (estrogen synthesis) has been reported in the penis, making the penis the latest "frontier" in the study of estrogen in male reproduction. ER and aromatase are broadly and abundantly expressed in various penile compartments and cell types (erectile tissues, urethral epithelia, vascular and neuronal cells), suggesting the complexity and significance of the estrogen-ER system in penile events. Unraveling this complexity is important and will require utilization of the various resources that are now at our disposal including, animal models and human lacking or deficient in ER and aromatase and the use of advanced and sensitive techniques. Some of the obvious areas that require our attention include: 1) a comprehensive mapping of ER-alpha and -beta cellular expression in the different penile compartments and subpopulations of cells, 2) delineation of the specific roles of estrogen in the different subpopulations of cells, 3) establishing the relationship of the estrogen-ER system with the androgen-androgen receptor system, if any, and 4) characterizing the specific penile phenotypes in human and animals lacking or deficient in estrogen and ER. Some data generated thus far, although preliminary, appear to challenge the long held dogma that, overall, androgens have a regulatory monopoly of penile development and function.

Intensification of constructed wetlands for land area reduction: a review.

PubMed

Ilyas, Huma; Masih, Ilyas

2017-05-01

The large land area requirement of constructed wetlands (CWs) is a major limitation of its application especially in densely populated and mountainous areas. This review paper provides insights on different strategies applied for the reduction of land area including stack design and intensification of CWs with different aeration methods. The impacts of different aeration methods on the performance and land area reduction were extensively and critically evaluated for nine wetland systems under three aeration strategies such as tidal flow (TF), effluent recirculation (ER), and artificial aeration (AA) applied on three types of CWs including vertical flow constructed wetland (VFCW), horizontal flow constructed wetland (HFCW), and hybrid constructed wetland (HCW). The area reduction and pollutant removal efficiency showed substantial variation among different types of CWs and aeration strategies. The ER-VFCW designated the smallest footprint of 1.1 ± 0.5 m 2 PE -1 (population equivalent) followed by TF-VFCW with the footprint of 2.1 ± 1.8 m 2 PE -1 , and the large footprint was of AA-HFCW (7.8 ± 4.7 m 2 PE -1 ). When footprint and removal efficiency both are the major indicators for the selection of wetland type, the best options for practical application could be TF-VFCW, ER-HCW, and AA-HCW. The data and results outlined in this review could be instructive for futures studies and practical applications of CWs for wastewater treatment, especially in land-limited regions.

77 FR 20817 - Diamond State Generation Partners, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-06

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1383-000] Diamond State Generation Partners, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Diamond State Generation Partners, LLC's application for market-based rate authority, with an accompanying...

78 FR 36180 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-17

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... Solar 1, LLC. Description: Imperial Valley Solar 1, LLC submit a revised horizontal market power.... Accession Number: 20130610-5000. Comments Due: 5 p.m. ET 7/1/13. Docket Numbers: ER13-1648-000. Applicants...

78 FR 28211 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice.... Applicants: Duke Energy Carolinas, LLC. Description: Compliance Filing ER13-959 to be effective 6/1/2011.... Description: OATT Revisions to Attachment N--LGIA and Attachment O--SGIA Compliance Filing to be effective 3/1...

76 FR 53121 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-25

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...: EG11-116-000. Applicants: Mesquite Solar 1, LLC. Description: Mesquite Solar 1, LLC Notice of Self...-5089. Comment Date: 5 p.m. Eastern Time on Thursday, September 1, 2011. Docket Numbers: ER11-4151-001...

77 FR 12276 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-29

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER11-4070-003...: Perrin Ranch Wind, LLC Second Amendment to MBR Application to be effective 1/1/2012. Filed Date: 2/17/12...

77 FR 28868 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-16

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER12-1660-001... Kansas Municipal Energy Agency NITSA NOA to be effective 4/1/2012. Filed Date: 5/9/12. Accession Number...

78 FR 50406 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER13-1851-001... effective 10/1/2013. Filed Date: 8/9/13. Accession Number: 20130809-5081. Comments Due: 5 p.m. ET 8/30/13...

77 FR 27041 - Combined Notice of Filings # 1

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...-161-003; ER12-164-002. Applicants: Forward Energy LLC, Sheldon Energy LLC, Invenergy Cannon Falls LLC, Spindle Hill Energy LLC, Spring Canyon Energy LLC, Grays Harbor Energy LLC, Grand Ridge Energy LLC, Willow...

75 FR 23750 - Combined Notice of Filings # 1

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-04

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 April 26, 2010. Take notice that the Commission received the following electric rate filings: Docket Numbers: ER98-411-017. Applicants: Wolverine Power Supply Cooperative, Inc. Description: Notification of Change in Status of Wolverine Power Supply Cooperative...

77 FR 47625 - Beebe Renewable Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-09

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2311-000] Beebe Renewable Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Beebe Renewable Energy, LLC's application for market-based rate authority, with an accompanying rate...

78 FR 28214 - Gainesville Renewable Energy Center, LLC; Supplemental Notice That Initial Market-Based Rate...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1348-000] Gainesville Renewable Energy Center, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Gainesville Renewable Energy Center, LLC's application for market- based rate authority, with an accompanying...

77 FR 64980 - Chesapeake Renewable Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-24

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-28-000] Chesapeake Renewable Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... proceeding of Chesapeake Renewable Energy LLC's application for market-based rate authority, with an...

78 FR 40473 - Plainfield Renewable Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1734-000] Plainfield Renewable Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Plainfield Renewable Energy, LLC's application for market-based rate authority, with an accompanying rate...

78 FR 44106 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-23

... (Whistler) Inc., FortisBC Huntingdon Inc., FortisBC Alternative Energy Services Inc. Description: FUCO Self... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...-5169. Comments Due: 5 p.m. ET 8/6/13. Docket Numbers: ER13-538-002. Applicants: Consumers Energy...

77 FR 48148 - Energy Alternatives Wholesale, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-13

... Energy Alternatives Wholesale, LLC's application for market-based rate authority, with an accompanying... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2413-000] Energy Alternatives Wholesale, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

76 FR 24469 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-02

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER10-3329-003... Corporation submits tariff filing per 35.13(a)(2)(iii: Rate Schedule No. 119 of Florida Power Corporation to...

78 FR 16261 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER13-1033-000...; Queue No. X2-038 to be effective 2/7/2013. Filed Date: 3/5/13. Accession Number: 20130305-5104. Comments...

76 FR 41773 - Combined Notice of Filings #3

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-15

... Eastern Energy, LP, AES Energy Storage, LLC, AES Alamitos, LLC, AES Redondo Beach, L.L.C., Condon Wind... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 3 Take notice...-2596-001, ER10-2597-001. Applicants: BP Energy Company, Fowler Ridge II Wind Farm LLC, Fowler Ridge III...

77 FR 55817 - Panther Creek Power Operating, LLC; Supplemental Notice that Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2570-000] Panther Creek Power Operating, LLC; Supplemental Notice that Initial Market-Based Rate Filing Includes Request for... Panther Creek Power Operating, LLC's application for market-based rate authority, with an accompanying...

75 FR 61739 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-06

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 September... Numbers: ER10-2968-000. Applicants: GenConn Energy LLC. Description: GenConn Energy LLC submits tariff filing per 35.12: GenConn Energy FERC Electric Tariff to be effective 9/24/2010. Filed Date: 09/24/2010...

78 FR 72670 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-03

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice.... ET 12/13/13. Docket Numbers: ER13-2109-001. Applicants: Fowler Ridge Wind Farm LLC. Description: Fowler Ridge Wind Farm LLC submits Compliance Filing-- Amdmt to New Baseline Filing to be effective 8/5...

76 FR 59681 - Middletown Coke Company, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-4525-000] Middletown Coke Company, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Middletown Coke Company, LLC's application for market-based rate authority, with an accompanying rate tariff...

75 FR 8052 - Stetson Wind II, LLC; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-23

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [ Docket No. ER10-426-001] Stetson Wind II, LLC; Notice of Filing February 12, 2010. Take notice that, on February 5, 2010, Stetson Wind II, LLC filed to amend, its filing in the above captioned docket with information required under the...

77 FR 53197 - Brandon Shores LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-31

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2510-000] Brandon Shores LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Brandon...

75 FR 80486 - Sustainable Star, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-22

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2354-000] Sustainable Star, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... proceeding of Sustainable Star, LLC's application for market-based rate authority, with an accompanying rate...

78 FR 29131 - Electricity MASS, LLC; Supplemental Notice that Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-17

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1440-000] Electricity MASS, LLC; Supplemental Notice that Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Electricity...

77 FR 35374 - Independence Electricity; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-13

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1926-000] Independence Electricity; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section... Electricity's application for market-based rate authority, with an accompanying rate tariff, noting that such...

78 FR 76606 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-18

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER13-2378-001. Applicants: Midcontinent Independent System Operator, Inc. Description: Midcontinent Independent System Operator, Inc. submits 12-11-2013 SA 2536 J238...

77 FR 27041 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER11-4266-003. Applicants: Richland-Stryker Generation LLC. Description: Supplemental to Notice of Non-Material Change in Status of Richland-Stryker Generation LLC....

78 FR 38705 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 June 20, 2013. Take notice that the Commission received the following electric rate filings: Docket Numbers: ER13-1164-001. Applicants: Ohio Power Company, American Electric Power Service Corporation, PJM Interconnection, L.L.C. Description: Ohio Power & AEP...

76 FR 21720 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-18

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER11-2434-002. Applicants: Wisconsin Electric Power Company. Description: Wisconsin Electric Power Company submits tariff filing per 35: FERC Rate Schedule 115 Amende...

77 FR 53194 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-31

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER12-2201-001. Applicants: Harvest II Windfarm, LLC. Description: Supplement to Application for Market-Based Rate Authorization to be effective 9/1/2012. Filed Date: ...

76 FR 37802 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-28

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER11-3243-001. Applicants: Southwest Power Pool, Inc. Description: Southwest Power Pool, Inc. submits tariff filing per: Amendment to Submission of Response to Reques...

78 FR 49504 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER13-2065-000. Applicants: Southern California Edison Company. Description: Amended SGIA & Distribution Service Agmt with Lancaster Little Rock C LLC to be effective ...

78 FR 38710 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER12-360-003. Applicants: New York Independent System Operator, Inc. Description: New York Independent System Operator, Inc. submits NYISO compliance filing in...

76 FR 62791 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER11-4525-001. Applicants: Middletown Coke Company, LLC. Description: Middletown Coke Company, LLC submits tariff filing per 35.17(b): Middletown Supplemental MBR to...

78 FR 79433 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-30

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER13-1402-003. Applicants: Arizona Public Service Company. Description: Request to Change Effective Date of Cancellation for Rate Schedule No. 38 of Arizona Public...

78 FR 38705 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER13-1188-010. Applicants: Pacific Gas and Electric Company. Description: Pacific Gas and Electric Company. submits Wholesale Distribution Tariff Rate Case 2013 (WDT2...

76 FR 61094 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-03

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice..., October 12, 2011. Docket Numbers: ER11-4567-001. Applicants: Pypha Energy LLC. Description: Pypha Energy LLC submits tariff filing per 35: Baseline MBR Tariff Filing to be effective 9/20/2011. Filed Date: 09...

75 FR 4062 - Cosa Geothermal Power Holdings, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-26

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-566-000] Cosa Geothermal Power Holdings, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...-referenced proceeding of Cosa Geothermal Power Holdings, LLC's application for market-based rate authority...

78 FR 28836 - Vulcan/BN Geothermal Power Company; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-16

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1273-000] Vulcan/BN Geothermal Power Company; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Vulcan/BN Geothermal Power Company's application for market-based rate authority, with an accompanying...

78 FR 60270 - Platinum Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-2436-000] Platinum Energy, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Platinum...

75 FR 61746 - New England Wire Technologies Corp; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-06

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-2754-000] New England Wire Technologies Corp; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...-referenced proceeding of New England Wire Technologies Corp's application for market-based rate authority...

75 FR 57016 - Maple Analytics, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-17

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-2541-000] Maple Analytics, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... proceeding of Maple Analytics, LLC's application for market-based rate authority, with an accompanying rate...

77 FR 63307 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-16

...: Collegiate Clean Energy, LLC submits tariff filing per 35.12: Market-Based Rate Tariff to be effective 11/5... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice... filings: Docket Numbers: ER13-32-000. Applicants: Topaz Solar Farms LLC. Description: Topaz Solar Farms...

76 FR 77815 - Ethical Electric Benefit Co.; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-543-000] Ethical Electric Benefit Co.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Ethical Electric Benefit Co.'s application for market-based rate authority, with an accompanying rate...

78 FR 72673 - Midcontinent Independent System Operator, Inc.; Supplemental Notice Concerning Post-Technical...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-03

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-2124-000] Midcontinent Independent System Operator, Inc.; Supplemental Notice Concerning Post-Technical Conference Comments As announced in the Notice of Technical Conference issued on October 25, 2013, and as required in the...

75 FR 61473 - New Hampshire Industries, Inc.; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-2887-000] New Hampshire Industries, Inc.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... proceeding of New Hampshire Industries, Inc.'s application for market-based rate authority, with an...

78 FR 68047 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-13

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER12-2317-001. Applicants: New York Independent System Operator, Inc. Description: NYISO compliance filing re: NYPA's amended annual transmission revenue rqrmnt to be...

78 FR 56223 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-12

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER13-298-001. Applicants: New York Independent System Operator, Inc. Description: NYISO compliance filing re: Ancillary Services Mitigation step increase to be...

78 FR 61943 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-07

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER11-4636-003. Applicants: Portland General Electric Company. Description: Colstrip compliance filing to be effective 10/1/2013. Filed Date: 9/27/13. Accession Number...

78 FR 41049 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-09

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER10-1651-002. Applicants: Golden State Water Company. Description: Updated market power analysis of Golden State Water Company. Filed Date: 6/27/13. Accession Number...

78 FR 26024 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-03

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER13-1340-000. Applicants: Midwest Independent Transmission System Operator, Inc. Description: 2013-04-25 Schedule 2 LBA References to be effective 8/1/2013. Filed...

78 FR 67137 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER14-263-000. Applicants: Midcontinent Independent System Operator, Inc. Description: Midcontinent Independent System Operator, Inc. submits tariff filing per 35.13(a...

78 FR 63174 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-23

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER13-107-005. Applicants: South Carolina Electric & Gas Company. Description: South Carolina Electric & Gas Company submits Order No. 1000 10.16.2013 to be effective...

78 FR 50410 - Black Bear Development Holdings, LLC; Supplemental Notice that Initial Market-Based Rate Filing...

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2013-08-19

... Black Bear Development Holdings, LLC's application for market-based rate authority, with an accompanying... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-2143-000] Black Bear Development Holdings, LLC; Supplemental Notice that Initial Market-Based Rate Filing Includes Request for...

77 FR 52016 - Brookfield Smoky Mountain Hydropower LLC; Supplemental Notice That Initial Market-Based Rate...

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2012-08-28

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2447-001] Brookfield Smoky Mountain Hydropower LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes... proceeding, of Brookfield Smoky Mountain Hydropower LLC's application for market- based rate authority, with...

76 FR 55377 - Bellevue Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

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2011-09-07

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-4380-000] Bellevue Solar, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... Solar, LLC's application for market-based rate authority, with an accompanying rate tariff, noting that...

77 FR 48148 - Helvetia Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

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2012-08-13

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2405-000] Helvetia Solar, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... Solar, LLC's application for market-based rate authority, with an accompanying rate schedule, noting...

76 FR 55378 - Yamhill Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

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2011-09-07

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [ Docket No. ER11-4381-000] Yamhill Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Solar, LLC's application for market-based rate authority, with an accompanying rate tariff, noting that...

77 FR 58827 - Catalina Solar, LLC; Supplemental Notice that Initial Market-Based Rate Filing Includes Request...

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2012-09-24

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2627-000] Catalina Solar, LLC; Supplemental Notice that Initial Market- Based Rate Filing Includes Request for Blanket... Solar, LLC's application for market-based rate authority, with an accompanying rate schedule, noting...

78 FR 34372 - Catalina Solar Lessee, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

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2013-06-07

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1562-000] Catalina Solar Lessee, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Catalina Solar Lessee, LLC's application for market-based rate authority, with an accompanying rate...

78 FR 62301 - Mountain View Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

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2013-10-15

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER14-21-000] Mountain View Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... View Solar, LLC's application for market-based rate authority, with an accompanying rate schedule...

76 FR 25329 - Torofino Physical Trading LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

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2011-05-04

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3432-000] Torofino Physical Trading LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Torofino Physical Trading LLC's application for market-based rate authority, with an accompanying rate...

77 FR 9226 - Physical Systems Integration, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

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2012-02-16

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1013-000] Physical Systems Integration, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Physical Systems Integration, LLC's application for market-based rate authority, with an accompanying rate...

78 FR 63176 - Notice Announcing Workshop; Zero Rate Reactive Power Rate Schedules

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2013-10-23

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. AD14-1-000] Notice Announcing Workshop; Zero Rate Reactive Power Rate Schedules Concurrent with this notice, the Commission is issuing an order in Chehalis Power Generating, L.P., Docket No. ER05-1056-007 clarifying its policy...

76 FR 54764 - Southwest Power Pool, Inc.; Notice of Filing

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2011-09-02

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3627-000] Southwest Power Pool, Inc.; Notice of Filing Take notice that, on August 24, 2011, Southwest Power Pool, Inc. filed to supplement its May 24, 2011 filing of revisions to its Open Access Transmission Tariff, in the...

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2012-05-09

... Liberty Power Wholesale Supply, LLC's application for market-based rate authority, with an accompanying... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1707-000] Liberty Power Wholesale Supply, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

75 FR 53688 - Constellation Mystic Power, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

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2010-09-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-2281-000] Constellation... proceeding of Constellation Mystic Power, LLC's application for market-based rate authority, with an... CFR part 34, of future issuances of securities and assumptions of liability. Any person desiring to...

77 FR 57082 - Prairie Rose Wind, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

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2012-09-17

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2542-000] Prairie Rose Wind, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... Rose Wind, LLC's application for market-based rate authority, with an accompanying rate schedule...

78 FR 75560 - Biofuels Washington LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

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2013-12-12

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER14-506-000] Biofuels Washington LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Biofuels...

78 FR 34371 - Centinela Solar Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

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2013-06-07

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1561-000] Centinela Solar Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Centinela Solar Energy, LLC's application for market-based rate authority, with an accompanying rate...

77 FR 42722 - Berry Petroleum Company; Supplemental Notice That Initial Market-Based Rate Filing Includes...

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2012-07-20

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2233-000] Berry Petroleum Company; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Petroleum Company's application for market-based rate authority, with an accompanying rate schedule, noting...

76 FR 25328 - New Mexico Green Initiatives, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

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2011-05-04

... Mexico Green Initiatives, LLC's application for market-based rate authority, with an accompanying rate... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3431-000] New Mexico Green Initiatives, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

76 FR 31604 - Lyonsdale Biomass LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

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2011-06-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3620-000] Lyonsdale Biomass LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... Biomass LLC's application for market-based rate authority, with an accompanying rate tariff, noting that...

78 FR 61946 - Pheasant Run Wind, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

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2013-10-07

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-2461-000] Pheasant Run Wind, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... Run Wind, LLC's application for market-based rate authority, with an accompanying rate schedule...

76 FR 13401 - Vectren Retail, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

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2011-03-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2997-000] Vectren Retail, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... Retail, LLC's application for market-based rate authority, with an accompanying rate tariff, noting that...

78 FR 36768 - Electron Hydro, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

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2013-06-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1646-000] Electron Hydro, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Electron...

75 FR 16098 - Reliable Power LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

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2010-03-31

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [ Docket No. ER10-881-000] Reliable Power LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... of Reliable Power, LLC's application for market-based rate authority, with an accompanying rate...

77 FR 6109 - Mariposa Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

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2012-02-07

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-896-000] Mariposa Energy, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Mariposa...

77 FR 60984 - World Digital Innovations; Supplemental Notice That Initial Market-Based Rate Filing Includes...

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2012-10-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2654-001] World Digital Innovations; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of World Digital...

76 FR 54764 - Marathon Power LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

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2011-09-02

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-4357-000] Marathon Power LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Marathon...

75 FR 27599 - Notice of Issuance of Regulatory Guide

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2010-05-17

..., Revision 2, ``Preparation of an Environmental Report To Support a Rulemaking Petition Seeking an Exemption... staff uses in evaluating specific problems or postulated accidents, and data that the staff needs in its... preparation of environmental reports (ERs), that are submitted to support a rulemaking petition for an...

75 FR 61747 - Union Leader Corporation; Supplemental Notice That Initial Market-Based Rate Filing Includes...

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2010-10-06

... of Union Leader Corporation's application for market-based rate authority, with an accompanying rate... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-2780-000] Union Leader Corporation; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section...

75 FR 5307 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-02

...: ER99-845-019. Applicants: Puget Sound Energy, Inc. Description: Puget Sound Energy, Inc.'s Notice of... Colorado Wind Energy, LLC, et al. Filed Date: 01/21/2010. Accession Number: 20100122-0201. Comment Date: 5... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 January 26...

76 FR 49463 - Combined Notice of Filings #2

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2011-08-10

... electric rate filings: Docket Numbers: ER11-4195-000. Applicants: Puget Sound Energy, Inc. Description: Puget Sound Energy, Inc. submits tariff filing per 35.1: Rate Schedule No. 94 to be effective 10/1/2011... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice...

78 FR 77116 - Combined Notice of Filings #1

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2013-12-20

...: ER14-618-000. Applicants: Puget Sound Energy, Inc. Description: Puget Sound Energy, Inc. submits tariff... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice...: Amended Oakfield Wind Farm LGIA Compliance Filing to be effective 10/11/2013. Filed Date: 12/12/13...

75 FR 42745 - Hardscrabble Wind Power LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

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2010-07-22

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-1725-000] Hardscrabble Wind Power LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... of Hardscrabble Wind Power LLC's application for market-based rate authority, with an accompanying...

77 FR 62510 - Niagara Wind Power, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

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2012-10-15

... Wind Power, LLC's application for market-based rate authority, with an accompanying rate schedule... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-17-000] Niagara Wind Power, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket...

75 FR 74712 - Planet Energy (Maryland) Corp.; Supplemental Notice That Initial Market-Based Rate Filing...

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2010-12-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2168-000] Planet Energy (Maryland) Corp.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... proceeding, of Planet Energy (Maryland) Corp.'s application for market-based rate authority, with an...

78 FR 62615 - Healthy Planet Partners Energy Company, LLC; Supplemental Notice that Initial Market-Based Rate...

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2013-10-22

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER14-96-000] Healthy Planet Partners Energy Company, LLC; Supplemental Notice that Initial Market-Based Rate Filing Includes Request... of Healthy Planet Partners Energy Company, LLC's application for market- based rate authority, with...

75 FR 74711 - Planet Energy (Pennsylvania) Corp.; Supplemental Notice That Initial Market-Based Rate Filing...

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2010-12-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2167-000] Planet Energy (Pennsylvania) Corp.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... proceeding, of Planet Energy (Pennsylvania) Corp.'s application for market-based rate authority, with an...

75 FR 38809 - Southern Turner Cimarron I, LLC; Notice of Filing

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2010-07-06

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-892-000] Southern Turner Cimarron I, LLC; Notice of Filing June 25, 2010. Take notice that on June 24, 2010, Southern Turner Cimarron I, LLC filed a supplement confirming passive ownership structure for informational...

Ca2+ influx-mediated dilation of the endoplasmic reticulum and c-FLIPL downregulation trigger CDDO-Me–induced apoptosis in breast cancer cells

PubMed Central

Lee, A Reum; Yoon, Mi Jin; Cho, Hyeseong; Lee, Jong-Soo; Choi, Kyeong Sook

2015-01-01

The synthetic triterpenoid 2-cyano-3, 12-dioxooleana-1, 9(11)-dien-C28-methyl ester (CDDO-Me) is considered a promising anti-tumorigenic compound. In this study, we show that treatment with CDDO-Me induces progressive endoplasmic reticulum (ER)-derived vacuolation in various breast cancer cells and ultimately kills these cells by inducing apoptosis. We found that CDDO-Me–induced increases in intracellular Ca2+ levels, reflecting influx from the extracellular milieu, make a critical contribution to ER-derived vacuolation and subsequent cell death. In parallel with increasing Ca2+ levels, CDDO-Me markedly increased the generation of reactive oxygen species (ROS). Interestingly, there exists a reciprocal positive-regulatory loop between Ca2+ influx and ROS generation that triggers ER stress and ER dilation in response to CDDO-Me. In addition, CDDO-Me rapidly reduced the protein levels of c-FLIPL (cellular FLICE-inhibitory protein) and overexpression of c-FLIPL blocked CDDO-Me–induced cell death, but not vacuolation. These results suggest that c-FLIPL downregulation is a key contributor to CDDO-Me–induced apoptotic cell death, independent of ER-derived vacuolation. Taken together, our results show that ER-derived vacuolation via Ca2+ influx and ROS generation as well as caspase activation via c-FLIPL downregulation are responsible for the potent anticancer effects of CDDO-Me on breast cancer cells. PMID:26053096

Ca2+ influx-mediated dilation of the endoplasmic reticulum and c-FLIPL downregulation trigger CDDO-Me-induced apoptosis in breast cancer cells.

PubMed

Jeong, Soo Ah; Kim, In Young; Lee, A Reum; Yoon, Mi Jin; Cho, Hyeseong; Lee, Jong-Soo; Choi, Kyeong Sook

2015-08-28

The synthetic triterpenoid 2-cyano-3, 12-dioxooleana-1, 9(11)-dien-C28-methyl ester (CDDO-Me) is considered a promising anti-tumorigenic compound. In this study, we show that treatment with CDDO-Me induces progressive endoplasmic reticulum (ER)-derived vacuolation in various breast cancer cells and ultimately kills these cells by inducing apoptosis. We found that CDDO-Me-induced increases in intracellular Ca2+ levels, reflecting influx from the extracellular milieu, make a critical contribution to ER-derived vacuolation and subsequent cell death. In parallel with increasing Ca2+ levels, CDDO-Me markedly increased the generation of reactive oxygen species (ROS). Interestingly, there exists a reciprocal positive-regulatory loop between Ca2+ influx and ROS generation that triggers ER stress and ER dilation in response to CDDO-Me. In addition, CDDO-Me rapidly reduced the protein levels of c-FLIPL (cellular FLICE-inhibitory protein) and overexpression of c-FLIPL blocked CDDO-Me-induced cell death, but not vacuolation. These results suggest that c-FLIPL downregulation is a key contributor to CDDO-Me-induced apoptotic cell death, independent of ER-derived vacuolation. Taken together, our results show that ER-derived vacuolation via Ca2+ influx and ROS generation as well as caspase activation via c-FLIPL downregulation are responsible for the potent anticancer effects of CDDO-Me on breast cancer cells.

Quantification of Estrogen Receptor Expression in Normal Breast Tissue in Postmenopausal Women With Breast Cancer and Association With Tumor Subtypes.

PubMed

Gulbahce, H Evin; Blair, Cindy K; Sweeney, Carol; Salama, Mohamed E

2017-09-01

Estrogen exposure is important in the pathogenesis of breast cancer and is a contributing risk factor. In this study we quantified estrogen receptor (ER) alpha expression in normal breast epithelium (NBR) in women with breast cancer and correlated it with breast cancer subtypes. Tissue microarrays were constructed from 204 breast cancer patients for whom normal breast tissue away from tumor was available. Slides stained with ER were scanned and expression in normal terminal duct lobular epithelium was quantitated using computer-assisted image analysis. ER expression in normal terminal duct lobular epithelium of postmenopausal women with breast cancer was significantly associated with estrogen and triple (estrogen, progesterone receptors, and HER2) negative phenotypes. Also increased age at diagnosis was significantly associated with ER expression in NBR. ER positivity in normal epithelium did not vary by tumor size, lymph node status, tumor grade, or stage. On the basis of quantitative image analysis, we confirm that ER expression in NBR increases with age in women with breast cancer, and report for the first time, a significant association between ER expression in NBR with ER-negative and triple-negative cancers in postmenopausal women.

Comparison of Estrogen Receptor Assay Results from Pathology Reports with Results from Central Laboratory Testing: Implications for Population-Based Studies of Breast Cancer

PubMed Central

Collins, LC; Marotti, J; Baer, HJ; Deitz, AC; Colditz, GA; Tamimi, RM

2014-01-01

Population-based studies of women with breast cancer commonly utilize information culled from pathology reports rather than central pathology review. The reliability of this information, particularly with regard to tumor biomarker results, is of concern. To address this, we evaluated the concordance between estrogen receptor (ER) results as determined from the original pathology reports and ER results obtained on the same specimens following testing in a single laboratory. Tissue microarrays (TMAs) were constructed from paraffin blocks of 3,167 breast cancers that developed in women enrolled in the Nurses’ Health Study. ER immunostains were performed on all TMA sections in single run. Results of ER immunostains performed on the TMA sections were compared with ER assay results abstracted from pathology reports. Among 1,851 cases of invasive breast cancer in which both ER results from pathology reports and central ER test results were available, the reported ER status and the ER status as determined from immunostains on TMAs were in agreement in 1,651 cases (87.3 %; kappa value 0.64, p<0.0001). When the comparison was restricted to ER assays originally performed by immunohistochemistry, the agreement rate increased to 92.3% (kappa value 0.78, p<0.0001). These results provide a framework for the accuracy of ER results abstracted from clinical records. Further, they suggest that utilizing ER assay results from pathology reports is a reasonable, albeit imperfect, alternative to central laboratory ER testing for large, population-based studies of patients with breast cancer. PMID:18230800

Predicting sugar-sweetened behaviours with theory of planned behaviour constructs: Outcome and process results from the SIPsmartER behavioural intervention

PubMed Central

Zoellner, Jamie M.; Porter, Kathleen J.; Chen, Yvonnes; Hedrick, Valisa E.; You, Wen; Hickman, Maja; Estabrooks, Paul A.

2017-01-01

Objective Guided by the theory of planned behaviour (TPB) and health literacy concepts, SIPsmartER is a six-month multicomponent intervention effective at improving SSB behaviours. Using SIPsmartER data, this study explores prediction of SSB behavioural intention (BI) and behaviour from TPB constructs using: (1) cross-sectional and prospective models and (2) 11 single-item assessments from interactive voice response (IVR) technology. Design Quasi-experimental design, including pre- and post-outcome data and repeated-measures process data of 155 intervention participants. Main Outcome Measures Validated multi-item TPB measures, single-item TPB measures, and self-reported SSB behaviours. Hypothesised relationships were investigated using correlation and multiple regression models. Results TPB constructs explained 32% of the variance cross sectionally and 20% prospectively in BI; and explained 13–20% of variance cross sectionally and 6% prospectively. Single-item scale models were significant, yet explained less variance. All IVR models predicting BI (average 21%, range 6–38%) and behaviour (average 30%, range 6–55%) were significant. Conclusion Findings are interpreted in the context of other cross-sectional, prospective and experimental TPB health and dietary studies. Findings advance experimental application of the TPB, including understanding constructs at outcome and process time points and applying theory in all intervention development, implementation and evaluation phases. PMID:28165771

Excessive endoplasmic reticulum stress and decreased neuroplasticity-associated proteins in prefrontal cortex of obese rats and the regulatory effects of aerobic exercise.

PubMed

Li, Feng; Liu, Bei Bei; Cai, Ming; Li, Jing Jing; Lou, Shu-Jie

2018-04-06

Studies have shown high fat diet induced obesity may cause cognition impairment and down-regulation of neuroplasticity-associated proteins, while aerobic exercise could improve that damage. Endoplasmic reticulum stress (ERS) has been reported to play a key role in regulating neuroplasticity-associated proteins expression, folding and post-translational modification in hippocampus of obese rodent models, however, the effects of ERS on neuroplasticity-associated proteins and possible underlying mechanisms in prefrontal cortex are not fully clear. In order to clarify changes of neuroplasticity-associated proteins and ERS in the prefrontal cortex of obese rats, male SD rats were fed on high fat diet for 8 weeks to establish the obese model. Then, 8 weeks of aerobic exercise treadmill intervention was arranged for the obese rats. Results showed that high fat diet induced obesity caused hyperlipidemia, and significantly promoted FATP1 expression in the prefrontal cortex, meanwhile, we found up-regulation of GRP78, p-PERK, p-eIF2α, caspase-12, CHOP, and Bax/Bcl-2, reflecting the activation of ERS and ERS-mediated apoptosis. Moreover, reduced BDNF and SYN was found in obese rats. However, FATP1, GRP78, p-PERK, p-eIF2α, caspase-12, CHOP, and Bax/Bcl-2 expressions were obviously reversed by aerobic exercise intervention. These results suggested that dietary obesity could induce Prefrontal ERS in SD rats and excessive ERS may play a critical role in decreasing the levels of neuroplasticity-associated proteins. Moreover, aerobic exercise could relieve ERS, thus promoted the expression of neuroplasticity-associated proteins. Copyright © 2018. Published by Elsevier Inc.

Penalized differential pathway analysis of integrative oncogenomics studies.

PubMed

van Wieringen, Wessel N; van de Wiel, Mark A

2014-04-01

Through integration of genomic data from multiple sources, we may obtain a more accurate and complete picture of the molecular mechanisms underlying tumorigenesis. We discuss the integration of DNA copy number and mRNA gene expression data from an observational integrative genomics study involving cancer patients. The two molecular levels involved are linked through the central dogma of molecular biology. DNA copy number aberrations abound in the cancer cell. Here we investigate how these aberrations affect gene expression levels within a pathway using observational integrative genomics data of cancer patients. In particular, we aim to identify differential edges between regulatory networks of two groups involving these molecular levels. Motivated by the rate equations, the regulatory mechanism between DNA copy number aberrations and gene expression levels within a pathway is modeled by a simultaneous-equations model, for the one- and two-group case. The latter facilitates the identification of differential interactions between the two groups. Model parameters are estimated by penalized least squares using the lasso (L1) penalty to obtain a sparse pathway topology. Simulations show that the inclusion of DNA copy number data benefits the discovery of gene-gene interactions. In addition, the simulations reveal that cis-effects tend to be over-estimated in a univariate (single gene) analysis. In the application to real data from integrative oncogenomic studies we show that inclusion of prior information on the regulatory network architecture benefits the reproducibility of all edges. Furthermore, analyses of the TP53 and TGFb signaling pathways between ER+ and ER- samples from an integrative genomics breast cancer study identify reproducible differential regulatory patterns that corroborate with existing literature.

Process and Energy Optimization Assessment, Rock Island Arsenal, IL

DTIC Science & Technology

2004-09-01

Approved for public release; distribution is unlimited. ER D C /C ER L TR -0 4- 17 Process and Energy Optimization Assessment Rock Island... Optimization Assessment: Rock Island Arsenal, IL Mike C.J. Lin, Alexander M. Zhivov, and Veera M. Boddu, Construction Engineering Research...and Energy Optimization Assessment (PEOA) was conducted at Rock Island Arsenal (RIA), IL to identify process, energy, and environmental opportunities

A Systems Biological View of Life-and-Death Decision with Respect to Endoplasmic Reticulum Stress-The Role of PERK Pathway.

PubMed

Márton, Margita; Kurucz, Anita; Lizák, Beáta; Margittai, Éva; Bánhegyi, Gábor; Kapuy, Orsolya

2017-01-05

Accumulation of misfolded/unfolded proteins in the endoplasmic reticulum (ER) leads to the activation of three branches (Protein kinase (RNA)-like endoplasmic reticulum kinase [PERK], Inositol requiring protein 1 [IRE-1] and Activating trascription factor 6 [ATF6], respectively) of unfolded protein response (UPR). The primary role of UPR is to try to drive back the system to the former or a new homeostatic state by self-eating dependent autophagy, while excessive level of ER stress results in apoptotic cell death. Our study focuses on the role of PERK- and IRE-1-induced arms of UPR in life-or-death decision. Here we confirm that silencing of PERK extends autophagy-dependent survival, whereas the IRE-1-controlled apoptosis inducer is downregulated during ER stress. We also claim that the proper order of surviving and self-killing mechanisms is controlled by a positive feedback loop between PERK and IRE-1 branches. This regulatory network makes possible a smooth, continuous activation of autophagy with respect to ER stress, while the induction of apoptosis is irreversible and switch-like. Using our knowledge of molecular biological techniques and systems biological tools we give a qualitative description about the dynamical behavior of PERK- and IRE-1-controlled life-or-death decision. Our model claims that the two arms of UPR accomplish an altered upregulation of autophagy and apoptosis inducers during ER stress. Since ER stress is tightly connected to aging and age-related degenerative disorders, studying the signaling pathways of UPR and their role in maintaining ER proteostasis have medical importance.

77 FR 28590 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-15

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER12-199-004... NITSA NOA and Cancellation of SAs 1863R1, 1975R1, 2014R1 & 2015R1 to be effective 4/1/2012. Filed Date...

75 FR 359 - Google Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

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2010-01-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-468-000] Google Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section... of Google Energy LLC's application for market-based rate authority, with an accompanying rate tariff...

77 FR 71587 - Badger Creek Limited; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

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2012-12-03

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-445-000] Badger Creek Limited; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Badger Creek...

76 FR 69720 - Northampton Generating Company, L.P.; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-09

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-281-000] Northampton Generating Company, L.P.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Northampton Generating Company, L.P.'s application for market-based rate authority, with an accompanying rate...

77 FR 280 - Rhode Island Engine Genco LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-04

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-674-000] Rhode Island Engine Genco LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Engine Genco LLC's application for market-based rate authority, with an accompanying rate tariff, noting...

78 FR 34372 - TGP Energy Management, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-07

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1586-000] TGP Energy Management, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of TGP Energy...

76 FR 7558 - GBC Metals LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-10

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2825-000] GBC Metals LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of GBC Metals LLC's...

78 FR 18583 - EconoPower, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1132-000] EconoPower, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of EconoPower, LLC...

75 FR 68350 - Oregon Trail Wind Park, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-1885-000] Oregon Trail Wind Park, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... proceeding of Oregon Trail Wind Park, LLC's application for market-based rate authority, with an accompanying...

76 FR 10581 - Settlers Trail Wind Farm, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-25

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2904-000] Settlers Trail Wind Farm, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Settlers Trail Wind Farm, LLC's application for market-based rate authority, with an accompanying rate...

76 FR 10581 - Pioneer Trail Wind Farm, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-25

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2905-000] Pioneer Trail Wind Farm, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Trail Wind Farm, LLC's application for market-based rate authority, with an accompanying rate tariff...

76 FR 26283 - Blue Chip Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-06

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3467-000] Blue Chip Energy LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Blue Chip...

78 FR 34371 - Magnolia Energy LP; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-07

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1578-000] Magnolia Energy LP; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Magnolia Energy...

75 FR 52528 - FC Landfill Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-26

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-2268-000] FC Landfill Energy, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... proceeding, of FC Landfill Energy, LLC's application for market-based rate authority, with an accompanying...

77 FR 25999 - PGPV, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-02

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1603-000] PGPV, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of PGPV, LLC's application for...

77 FR 35669 - AltaGas Renewable Energy Colorado LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1875-000] AltaGas Renewable Energy Colorado LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request... of AltaGas Renewable Energy Colorado LLC application for market-based rate authority, with an...

77 FR 2718 - CPV Cimarron Renewable Energy Company, LLC; Supplemental Notice That Initial Market-Based Rate...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-775-000] CPV Cimarron Renewable Energy Company, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request... of CPV Cimarron Renewable Energy Company, LLC's application for market- based rate authority, with an...

77 FR 62509 - Big Blue Wind Farm, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-15

... Wind Farm, LLC's application for market-based rate authority, with an accompanying rate schedule... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-18-000] Big Blue Wind Farm, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket...

75 FR 63466 - Flat Water Wind Farm, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-15

... proceeding of Flat Water Wind Farm, LLC's application for market-based rate authority, with an accompanying... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-39-000] Flat Water Wind Farm, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket...

75 FR 27339 - Blackstone Wind Farm II, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-1184-000] Blackstone Wind Farm II, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... proceeding of Blackstone Wind Farm, LLCs application for market-based rate authority, with an accompanying...

76 FR 23580 - Dempsey Ridge Wind Farm, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3391-000] Dempsey Ridge Wind Farm, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Ridge Wind Farm, LLC's application for market-based rate authority, with an accompanying rate tariff...

76 FR 72697 - Heritage Garden Wind Farm I, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-25

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-421-000] Heritage Garden Wind Farm I, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Heritage Garden Wind Farm I, LLC's application for market-based rate authority, with an accompanying rate...

75 FR 48665 - Heritage Stoney Corners Wind Farm I, LLC; Supplemental Notice That Initial Market-Based Rate...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-2108-000] Heritage Stoney Corners Wind Farm I, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...-referenced proceeding, of Heritage Stoney Corners Wind Farm I, LLC's application for market- based rate...

77 FR 20380 - Wildcat Wind Farm I, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-04

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1329-000] Wildcat Wind Farm I, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Wildcat Wind...

77 FR 36529 - Patton Wind Farm, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1925-000] Patton Wind Farm, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Patton Wind...

76 FR 11774 - Paulding Wind Farm II LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-03

... Wind Farm II LLC's application for market-based rate authority, with an accompanying rate tariff... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2935-000] Paulding Wind Farm II LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket...

75 FR 71426 - Blue Creek Wind Farm, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-23

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2112-000] Blue Creek Wind Farm, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... proceeding, of Blue Creek Wind Farm, LLC's application for market-based rate authority, with an accompanying...

77 FR 42301 - W Power, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-18

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2219-000] W Power, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of W Power, LLC's application...

78 FR 4143 - Energy Storage Holdings, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-18

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-752-000] Energy Storage... Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Energy Storage Holdings, LLC's application for market-based rate authority, with an accompanying rate schedule...

75 FR 44787 - RED-Scotia, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-29

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-1809-000] RED-Scotia... RED-Scotia, LLC's application for market-based rate authority, with an accompanying rate tariff... are also available for review in the Commission's Public Reference Room in Washington, DC. There is an...

75 FR 82381 - Oracle Energy Services, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-30

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2436-000] Oracle Energy Services, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... proceeding of Oracle Energy Services, LLC's application for market-based rate authority, with an accompanying...

75 FR 37430 - Plymouth Rock Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-29

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-1470-000] Plymouth Rock Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... of Plymouth Rock Energy, LLC.'s application for market-based rate authority, with an accompanying...

75 FR 42743 - Synergics Roth Rock North Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-22

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-1673-000] Synergics Roth Rock North Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...-referenced proceeding of Synergics Roth Rock North Wind Energy, LLC's application for market- based rate...

75 FR 42744 - Synergics Roth Rock Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-22

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-1637-000] Synergics Roth Rock Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...-referenced proceeding of Synergics Roth Rock Wind Energy, LLC's application for market-based rate authority...

75 FR 73074 - Duke Energy Hanging Rock II, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-29

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2064-000] Duke Energy Hanging Rock II, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... proceeding, of Duke Energy Hanging Rock II, LLC's application for market-based rate authority, with an...

76 FR 41238 - Post Rock Wind Power Project, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3959-000] Post Rock Wind Power Project, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Rock Wind Power Project, LLC's application for market-based rate authority, with an accompanying rate...

77 FR 64977 - Texas Dispatchable Wind 1, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-24

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-70-000] Texas Dispatchable Wind 1, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Texas Dispatchable Wind 1 LLC's application for market-based rate authority, with an accompanying rate...

77 FR 36529 - Apple Group LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-4657-001] Apple Group LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Apple Group LLC...

75 FR 18202 - Vantage Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-09

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-956-000] Vantage Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... of Vantage Wind Energy, LLC's application for market-based rate authority, with an accompanying rate...

75 FR 17406 - Stetson Wind II, LLC; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-06

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-426-000] Stetson Wind II, LLC; Notice of Filing March 31, 2010. Take notice that, on March 29, 2010, Stetson Wind II, LLC filed a supplement to its filing in the above captioned docket with information required under the...

75 FR 71425 - Border Energy Electric Services, Inc.; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-23

... proceeding, of Border Energy Electric Services, Inc.'s application for market-based rate authority, with an... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2088-000] Border Energy Electric Services, Inc.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

76 FR 40722 - Granite Reliable Power, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3941-000] Granite Reliable Power, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Granite...

78 FR 66353 - EAM Nelson Holdings, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-2349-000] EAM Nelson Holdings, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of EAM Nelson...

76 FR 22392 - Command Power Corp.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-21

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3336-000] Command Power Corp.; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Command Power...

77 FR 53884 - North Sky River Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-04

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2444-000] North Sky River Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... North Sky River Energy, LLC's application for market-based rate authority, with an accompanying rate...

77 FR 38048 - Blue Sky East, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-26

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2068-000] Blue Sky East, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Blue Sky East...

77 FR 56839 - GenOn Marsh Landing, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2545-000] GenOn Marsh Landing, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Landing, LLC's application for market-based rate authority, with an accompanying rate schedule, noting...

77 FR 69819 - The Proctor & Gamble Paper Products Company; Supplemental Notice That Initial Market-Based Rate...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-21

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-368-000] The Proctor & Gamble Paper Products Company; Supplemental Notice That Initial Market-Based Rate Filing Includes Request..., of The Proctor & Gamble Paper Products Company's application for market-based rate authority, with an...

77 FR 66976 - Star Energy Partners LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [ Docket No. ER13-281-000] Star Energy Partners LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Star Energy...

77 FR 33210 - Shooting Star Wind Project, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1829-000] Shooting Star Wind Project, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Shooting Star Wind Project, LLC's application for market-based rate authority, with an accompanying rate...

77 FR 73650 - Electricity NH, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-504-000] Electricity NH, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Electricity NH...

77 FR 62510 - C.N. Brown Electricity, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-15

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-20-000] C.N. Brown Electricity, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Electricity, LLC's application for market-based rate authority, with an accompanying rate schedule, noting...

76 FR 6614 - Elk Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-07

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2765-000] Elk Wind Energy, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... proceeding of Elk Wind Energy, LLC's application for market-based rate authority, with an accompanying rate...

77 FR 28594 - Bethel Wind Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-15

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1739-000] Bethel Wind Energy LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Bethel Wind...

77 FR 47625 - Laurel Hill Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-09

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2313-000] Laurel Hill Wind Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request For... Laurel Hill Wind Energy, LLC's application for market-based rate authority, with an accompanying rate...

78 FR 62300 - Prairie Breeze Wind Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-15

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER14-25-000] Prairie Breeze Wind Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Breeze Wind Energy LLC's application for market-based rate authority, with an accompanying rate schedule...

77 FR 106 - California Ridge Wind Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-03

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-645-000] California Ridge Wind Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... California Ridge Wind Energy LLC's application for market-based rate authority, with an accompanying rate...

77 FR 28593 - Rippey Wind Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-15

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1740-000] Rippey Wind Energy LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Rippey Wind...

77 FR 41400 - Mehoopany Wind Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-13

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2200-000] Mehoopany Wind Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Wind Energy LLC's application for market-based rate authority, with an accompanying rate tariff, noting...

76 FR 3624 - Milford Wind Corridor Phase II, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-20

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2657-000] Milford Wind Corridor Phase II, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... proceeding Milford Wind Corridor Phase II, LLC's application for market-based rate authority, with an...

78 FR 79431 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-30

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER14-661-000 Applicants: SG2 Imperial Valley LLC Description: SG2 Imperial Valley LLC submits Application for Initial Market-Based Rate Tariff and Granting Certain...

78 FR 34366 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-07

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER10-2331-020. Applicants: J.P. Morgan Ventures Energy Corporation. Description: Compliance filing to be effective 4/1/2013. Filed Date: 5/23/13. Accession Number:...

76 FR 35879 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-20

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER11-1829-002. Applicants: ISO New England Inc. Description: ISO New England Inc. submits tariff filing per 35: Conforming Tariff Record Filing to be effective 3/16...

77 FR 27043 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER11-3539-001. Applicants: Entergy Arkansas, Inc. Description: Entergy Arkansas, Inc. submits tariff filing per 35: Cleco. NITSA Cmpl to be effective 5/1/2011. Filed...

75 FR 61747 - Discount Energy Group, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-06

... proceeding of Discount Energy Group, LLC's application for market-based rate authority, with an accompanying... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-2803-000] Discount Energy Group, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket...

78 FR 18582 - FM Energy Scheduling, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1107-000] FM Energy Scheduling, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of FM Energy...

76 FR 44322 - Copper Mountain Solar 1, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-25

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-4055-000] Copper Mountain Solar 1, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Copper Mountain Solar 1, LLC's application for market-based rate authority, with an accompanying rate...

78 FR 16495 - Switch Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-15

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [ Docket No. ER13-1053-000] Switch Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Switch...

77 FR 20381 - Silver State Solar Power North, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-04

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1316-000] Silver State Solar Power North, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Silver State Solar Power North, LLC's application for market-based rate authority, with an accompanying...

76 FR 64341 - Silver State Solar Power North LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-18

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-32-000] Silver State Solar Power North LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Silver State Solar Power North, LLC's application for market-based rate authority, with an accompanying...

77 FR 71189 - AES Beaver Valley, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-29

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-442-000] AES Beaver Valley, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of AES Beaver...

75 FR 8326 - AES ES Westover, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-712-000] AES ES Westover, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... proceeding of AES ES Westover, LLC's application for market-based rate authority, with an accompanying rate...

75 FR 70742 - AES Laurel Mountain, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-18

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2036-000] AES Laurel Mountain, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... proceeding of AES Laurel Mountain, LLC's application for market-based rate authority, with an accompanying...

78 FR 36768 - Battery Utility of Ohio, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1667-000] Battery Utility of Ohio, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Battery Utility of Ohio, LLC's application for market-based rate authority, with an accompanying rate...

77 FR 20380 - Desert View Power, Inc.; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-04

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1320-000] Desert View Power, Inc.; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Desert View...

78 FR 45521 - Desert Sunlight 250, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1991-000] Desert Sunlight 250, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Desert...

75 FR 22776 - 511 Plaza Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-30

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-1064-000] 511 Plaza Energy, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization April 22, 2010. This is a supplemental notice in the above-referenced proceeding...

77 FR 47624 - Tall Bear Group, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-09

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2374-000] Tall Bear Group, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Tall Bear...

75 FR 27551 - Commercial Energy of Montana, Inc.; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-17

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-1090-000] Commercial Energy of Montana, Inc.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization May 10, 2010. This is a supplemental notice in the above-referenced...

78 FR 56690 - All Dams Generation, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-13

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-2318-000] All Dams Generation, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of All Dams...

75 FR 68354 - Milner Dam Wind Park, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-1883-000] Milner Dam Wind Park, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... proceeding of Milner Dam Wind Park, LLC's application for market-based rate authority, with an accompanying...

78 FR 26771 - Mesa Wind Power Corporation; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1346-000] Mesa Wind Power Corporation; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Mesa...

77 FR 53884 - High Mesa Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-04

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [ Docket No. ER12-2528-000] High Mesa Energy, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of High Mesa...

77 FR 36528 - K Road Modesto Solar LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1995-000] K Road Modesto Solar LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of K Road...

75 FR 61744 - The Order of St. Benedict of New Hampshire; Supplemental Notice That Initial Market-Based Rate...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-06

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-2750-000] The Order of St. Benedict of New Hampshire; Supplemental Notice That Initial Market-Based Rate Filing Includes... above-referenced proceeding of The Order of St. Benedict of New Hampshire's application for market...

78 FR 18584 - Spectrum Nevada Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1101-000] Spectrum Nevada Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Spectrum...

78 FR 61998 - Combined Notice of Filings #2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-10

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 2 Take notice that the Commission received the following electric rate filings: Docket Numbers: ER13-91-002. Applicants: El Paso Electric Company. Description: OATT Order No. 1000 Compliance Filing--Regional to be effective 12/31/9998. Filed Date: 9/30/13....

76 FR 5580 - Black Hills Colorado IPP, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-01

... proceeding Black Hills Colorado IPP, LLC's application for market-based rate authority, with an accompanying... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2724-000] Black Hills Colorado IPP, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket...

77 FR 66975 - Black Bear SO, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-203-000] Black Bear SO, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Black Bear SO...

75 FR 57015 - Kit Carson Windpower, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-17

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-2567-000] Kit Carson Windpower, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... proceeding of Kit Carson Windpower, LLC's application for market-based rate authority, with an accompanying...

78 FR 61999 - Simon Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-10

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-2490-000] Simon Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Simon Solar...

77 FR 24697 - Cooper Mountain Solar 2, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-25

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1566-000] Cooper Mountain Solar 2, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Cooper Mountain Solar 2, LLC's application for market-based rate authority, with an accompanying rate...

78 FR 49508 - Solar Partners I, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-2107-000] Solar Partners I, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Solar...

76 FR 40722 - Mojave Solar LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3917-000] Mojave Solar LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Mojave Solar LLC...

78 FR 29130 - Solar Star California XIX, LLC; Supplemental Notice that Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-17

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1441-000] Solar Star California XIX, LLC; Supplemental Notice that Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Solar Star...

76 FR 63614 - Agua Caliente Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-13

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-21-000] Agua Caliente Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Caliente Solar, LLC's application for market-based rate authority, with an accompanying rate tariff, noting...

77 FR 26538 - Topaz Solar Farms LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-04

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1626-000] Topaz Solar Farms LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Topaz Solar...

78 FR 46939 - Solar Partners II, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-02

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-2020-000 ] Solar Partners II, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket..., of Solar Partners II, LLC's application for market-based rate authority, with an accompanying rate...

76 FR 41240 - Mesquite Solar 1, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-13

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3987-000] Mesquite Solar 1, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... Solar 1, LLC's application for market-based rate authority, with an accompanying rate tariff, noting...

78 FR 29131 - Solar Star California XX, LLC; Supplemental Notice that Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-17

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1442-000] Solar Star California XX, LLC; Supplemental Notice that Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Solar Star...

78 FR 49507 - Genesis Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-2112-000] Genesis Solar, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Genesis Solar...

78 FR 5176 - CED White River Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-24

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-764-000] CED White River Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... River Solar, LLC's application for market-based rate authority, with an accompanying rate schedule...

76 FR 30935 - Long Island Solar Farm, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3589-000] Long Island Solar Farm, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Solar Farm, LLC's application for market-based rate authority, with an accompanying rate tariff, noting...

77 FR 48148 - NRG Solar Borrego I LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-13

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2398-000] NRG Solar Borrego I LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of NRG Solar...

77 FR 37666 - NRG Solar Avra Valley LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-22

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2019-000] NRG Solar Avra Valley LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of NRG Solar...

77 FR 47832 - Combined Notice of Filings #1

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-10

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings 1 Take notice... Mnt Vrbl Schdlng PJM Prxy Gnrtr Bs to be effective 6/27/2012. Filed Date: 7/12/12. Accession Number.../2012 Order in ER11-4628- Versions to be effective 6/1/2012. Filed Date: 7/13/12. Accession Number...

77 FR 19010 - Zone J Tolling Co., LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-29

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1301-000] Zone J Tolling Co., LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Zone J...

78 FR 27219 - Dominion Bridgeport Fuel Cell, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-09

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1403-000] Dominion Bridgeport Fuel Cell, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Dominion Bridgeport Fuel Cell, LLC's application for market-based rate authority, with an accompanying rate...

76 FR 2368 - Balance Power Systems, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-13

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2331-000] Balance Power Systems, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... proceeding of Balance Power Systems, LLC's application for market-based rate authority, with an accompanying...

76 FR 9346 - Sun City Project LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-17

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2857-000] Sun City Project LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Sun City...

77 FR 37035 - SunPower Corporation, Systems; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-20

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1989-000] SunPower Corporation, Systems; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of SunPower...

76 FR 43684 - Verde Energy USA Trading, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-21

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-4041-000] Verde Energy USA Trading, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Verde Energy USA Trading, LLC's application for market-based rate authority, with an accompanying rate...

77 FR 38280 - Verde Energy USA New York, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2071-000] Verde Energy USA New York, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Verde Energy USA New York, LLC's application for market-based rate authority, with an accompanying rate...

78 FR 34373 - Campo Verde Solar, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-07

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1541-000] Campo Verde Solar, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Campo Verde...

77 FR 5009 - Power Supply Services LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-862-000] Power Supply Services LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Power Supply...

78 FR 77670 - AlphaGen Power LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-24

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER14-630-000] AlphaGen Power LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of AlphaGen Power...

78 FR 2984 - Silver Bear Power, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-15

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-733-000] Silver Bear Power, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Silver Bear...

75 FR 59260 - HOP Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-27

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-2658-000] HOP Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section... of HOP Energy, LLC's application for market-based rate authority, with an accompanying rate tariff...

78 FR 28836 - Arlington Valley Solar Energy II, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-16

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1430-000] Arlington Valley Solar Energy II, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request..., of Arlington Valley Solar Energy II, LLC's application for market-based rate authority, with an...

76 FR 32188 - Hatch Solar Energy Center 1, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-03

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3635-000] Hatch Solar Energy Center 1, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Hatch Solar Energy Center 1, LLC's application for market-based rate authority, with an accompanying...

78 FR 28837 - Land O'Lakes, Inc.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-16

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1258-000] Land O'Lakes, Inc.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Land O'Lakes...

75 FR 10244 - TC Energy Trading, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-792-000] TC Energy Trading, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... proceeding of TC Energy Trading, LLC's application for market-based rate authority, with an accompanying rate...

76 FR 15306 - Macho Springs Power I, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-21

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3051-000] Macho Springs Power I, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Springs Power I, LLC's application for market-based rate authority, with an accompanying rate tariff...

75 FR 68351 - Thousand Springs Wind Park, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-1887-000] Thousand Springs Wind Park, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... proceeding of Thousand Springs Wind Park, LLC's application for market-based rate authority, with an...

77 FR 1484 - Spring Valley Wind LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-10

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-726-000] Spring Valley Wind LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Spring...

76 FR 79169 - Power Network New Mexico, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-21

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-605-000] Power Network New Mexico, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Power Network New Mexico, LLC's application for market-based rate authority, with an accompanying rate...

75 FR 68352 - Yahoo Creek Wind Park, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-1894-000] Yahoo Creek Wind Park, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... proceeding of Yahoo Creek Wind Park, LLC's application for market-based rate authority, with an accompanying...

78 FR 61946 - Pheasant Run Wind II, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-07

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-2462-000] Pheasant Run Wind II, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Run Wind II, LLC's application for market-based rate authority, with an accompanying rate schedule...

76 FR 73619 - Quantum Choctaw Power, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-29

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-458-000] Quantum Choctaw Power, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Quantum...

75 FR 61470 - Smart One Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-05

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-2943-000] Smart One Energy, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket... proceeding of Smart One Energy, LLC's application for market-based rate authority, with an accompanying rate...

78 FR 7774 - SmartEnergy Holdings, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-04

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-779-000] SmartEnergy Holdings, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of SmartEnergy...

75 FR 8325 - AEP Retail Energy Partners, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-727-000] AEP Retail Energy Partners, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... proceeding of AEP Retail Energy Partner, LLC's application for market-based rate authority, with an...

77 FR 27767 - Galaxy Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1692-000] Galaxy Energy LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Galaxy Energy...

78 FR 54463 - Town Square Energy, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-04

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-2223-000] Town Square Energy, LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Town Square...

78 FR 8511 - RPA Energy, Inc.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-06

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-826-000] RPA Energy, Inc.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of RPA Energy, Inc...

78 FR 64934 - BTG Pactual Commodities (US) LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-30

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER14-120-000] BTG Pactual Commodities (US) LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket... Commodities (US) LLC's application for market-based rate authority, with an accompanying rate schedule, noting...

76 FR 15307 - Holcim (US) Inc.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-21

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3053-000] Holcim (US) Inc.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Holcim (US) Inc...

77 FR 6557 - PJM Interconnection, L.L.C.; Supplemental Notice for Staff Technical Conference

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-4628-000] PJM Interconnection, L.L.C.; Supplemental Notice for Staff Technical Conference Take notice that the staff technical conference in the above captioned proceeding, to be held on February 14, 2012, will include a listen-only...

78 FR 6321 - PacifiCorp, et al; Notice of FERC Staff Attendance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-30

...Corp, et al; Notice of FERC Staff Attendance PacifiCorp Docket No. ER13-64-000 Deseret Generation... Regulatory Commission (Commission) hereby gives notice that on January 30, 2013, members of its staff will... and Commission staff's attendance is part of the Commission's ongoing outreach efforts. The meeting...

77 FR 23476 - Energia Sierra Juarez U.S., LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1470-000] Energia Sierra Juarez U.S., LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... Energia Sierra Juarez U.S., LLC's application for market-based rate authority, with an accompanying rate...

76 FR 56193 - KAP Analytics, LLC ; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-12

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-4440-000] KAP Analytics... 204 Authorization This is a supplemental notice in the above-referenced proceeding of KAP Analytics... eSubscription link on the Web site that enables subscribers to receive e-mail notification when a...

75 FR 74711 - Duke Energy Lee II, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

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2012-09-19

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... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-45-000] Dynamo Power LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Dynamo Power LLC...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Slade, Daniel J.; Fang, Pengfei; Dreyton, Christina J.

Protein arginine deiminases (PADs) are calcium-dependent histone-modifying enzymes whose activity is dysregulated in inflammatory diseases and cancer. PAD2 functions as an Estrogen Receptor (ER) coactivator in breast cancer cells via the citrullination of histone tail arginine residues at ER binding sites. Although an attractive therapeutic target, the mechanisms that regulate PAD2 activity are largely unknown, especially the detailed role of how calcium facilitates enzyme activation. To gain insights into these regulatory processes, we determined the first structures of PAD2 (27 in total), and through calcium-titrations by X-ray crystallography, determined the order of binding and affinity for the six calcium ionsmore » that bind and activate this enzyme. These structures also identified several PAD2 regulatory elements, including a calcium switch that controls proper positioning of the catalytic cysteine residue, and a novel active site shielding mechanism. Additional biochemical and mass-spectrometry-based hydrogen/deuterium exchange studies support these structural findings. The identification of multiple intermediate calcium-bound structures along the PAD2 activation pathway provides critical insights that will aid the development of allosteric inhibitors targeting the PADs.« less

Ego-resiliency reloaded: a three-component model of general resiliency.

PubMed

Farkas, Dávid; Orosz, Gábor

2015-01-01

Ego-resiliency (ER) is a capacity that enables individuals to adapt to constantly changing environmental demands. The goal of our research was to identify components of Ego-resiliency, and to test the reliability and the structural and convergent validity of the refined version of the ER11 Ego-resiliency scale. In Study 1 we used a factor analytical approach to assess structural validity and to identify factors of Ego-resiliency. Comparing alternative factor-structures, a hierarchical model was chosen including three factors: Active Engagement with the World (AEW), Repertoire of Problem Solving Strategies (RPSS), and Integrated Performance under Stress (IPS). In Study 2, the convergent and divergent validity of the ER11 scale and its factors and their relationship with resilience were tested. The results suggested that resiliency is a double-faced construct, with one function to keep the personality system stable and intact, and the other function to adjust the personality system in an adaptive way to the dynamically changing environment. The stability function is represented by the RPSS and IPS components of ER. Their relationship pattern is similar to other constructs of resilience, e.g. the Revised Connor-Davidson Resilience Scale (R-CD-RISC). The flexibility function is represented by the unit of RPSS and AEW components. In Study 3 we tested ER11 on a Hungarian online representative sample and integrated the results in a model of general resiliency. This framework allows us to grasp both the stability-focused and the plasticity-focused nature of resiliency.

Ego-Resiliency Reloaded: A Three-Component Model of General Resiliency

PubMed Central

Farkas, Dávid; Orosz, Gábor

2015-01-01

Ego-resiliency (ER) is a capacity that enables individuals to adapt to constantly changing environmental demands. The goal of our research was to identify components of Ego-resiliency, and to test the reliability and the structural and convergent validity of the refined version of the ER11 Ego-resiliency scale. In Study 1 we used a factor analytical approach to assess structural validity and to identify factors of Ego-resiliency. Comparing alternative factor-structures, a hierarchical model was chosen including three factors: Active Engagement with the World (AEW), Repertoire of Problem Solving Strategies (RPSS), and Integrated Performance under Stress (IPS). In Study 2, the convergent and divergent validity of the ER11 scale and its factors and their relationship with resilience were tested. The results suggested that resiliency is a double-faced construct, with one function to keep the personality system stable and intact, and the other function to adjust the personality system in an adaptive way to the dynamically changing environment. The stability function is represented by the RPSS and IPS components of ER. Their relationship pattern is similar to other constructs of resilience, e.g. the Revised Connor-Davidson Resilience Scale (R-CD-RISC). The flexibility function is represented by the unit of RPSS and AEW components. In Study 3 we tested ER11 on a Hungarian online representative sample and integrated the results in a model of general resiliency. This framework allows us to grasp both the stability-focused and the plasticity-focused nature of resiliency. PMID:25815881

New insights into estrogenic regulation of O6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O6-benzylguanine indicates fresh avenues for therapy.

PubMed

Paranjpe, Ameya; Bailey, Nathan I; Konduri, Santhi; Bobustuc, George C; Ali-Osman, Francis; Yusuf, Mohd A; Punganuru, Surendra R; Madala, Hanumantha Rao; Basak, Debasish; Mostofa, Agm; Srivenugopal, Kalkunte S

2016-09-01

Endocrine therapy using estrogen receptor-α (ER-α) antagonists for attenuating horm2one-driven cell proliferation is a major treatment modality for breast cancers. To exploit any DNA repair deficiencies associated with endocrine therapy, we investigated the functional and physical interactions of ER-α with O 6 -methylguanine DNA methyltransferase (MGMT), a unique DNA repair protein that confers tumor resistance to various anticancer alkylating agents. The ER-α -positive breast cancer cell lines (MCF-7, T47D) and ER- negative cell lines (MDAMB-468, MDAMB-231), and established inhibitors of ER-α and MGMT, namely, ICI-182,780 (Faslodex) and O 6 -benzylguanine, respectively, were used to study MGMT- ER interactions. The MGMT gene promoter was found to harbor one full and two half estrogen-responsive elements (EREs) and two antioxidant-responsive elements (AREs). MGMT expression was upregulated by estrogen, downregulated by tamoxifen in Western blot and promoter-linked reporter assays. Similarly, both transient and stable transfections of Nrf-2 (nuclear factor-erythroid 2-related factor-2) increased the levels of MGMT protein and activity 3 to 4-fold reflecting novel regulatory nodes for this drug-resistance determinant. Of the different ER-α antagonists tested, the pure anti-estrogen fulvestrant was most potent in inhibiting the MGMT activity in a dose, time and ER-α dependent manner, similar to O 6 -benzylguanine. Interestingly, fulvestrant exposure led to a degradation of both ER-α and MGMT proteins and O 6 -benzylguanine also induced a specific loss of ER-α and MGMT proteins in MCF-7 and T47D breast cancer cells with similar kinetics. Immunoprecipitation revealed a specific association of ER-α and MGMT proteins in breast cancer cells. Furthermore, silencing of MGMT gene expression triggered a decrease in the levels of both MGMT and ER-α proteins. The involvement of proteasome in the drug-induced degradation of both proteins was also demonstrated. Fulvestrant enhanced the cytotoxicity of MGMT-targeted alkylating agents, namely, temozolomide and BCNU by 3 to 4-fold in ER-α positive cells, but not in ER-negative cells. We conclude that MGMT and ER-α proteins exist as a complex and are co-targeted for ubiquitin-conjugation and subsequent proteasomal degradation. The findings offer a clear rationale for combining alkylating agents with endocrine therapy. © 2016 the Journal of Biomedical Research. All rights reserved.

Estrogen Receptor Folding Modulates cSrc Kinase SH2 Interaction via a Helical Binding Mode.

PubMed

Nieto, Lidia; Tharun, Inga M; Balk, Mark; Wienk, Hans; Boelens, Rolf; Ottmann, Christian; Milroy, Lech-Gustav; Brunsveld, Luc

2015-11-20

The estrogen receptors (ERs) feature, next to their transcriptional role, important nongenomic signaling actions, with emerging clinical relevance. The Src Homology 2 (SH2) domain mediated interaction between cSrc kinase and ER plays a key role in this; however the molecular determinants of this interaction have not been elucidated. Here, we used phosphorylated ER peptide and semisynthetic protein constructs in a combined biochemical and structural study to, for the first time, provide a quantitative and structural characterization of the cSrc SH2-ER interaction. Fluorescence polarization experiments delineated the SH2 binding motif in the ER sequence. Chemical shift perturbation analysis by nuclear magnetic resonance (NMR) together with molecular dynamics (MD) simulations allowed us to put forward a 3D model of the ER-SH2 interaction. The structural basis of this protein-protein interaction has been compared with that of the high affinity SH2 binding sequence GpYEEI. The ER features a different binding mode from that of the "two-pronged plug two-hole socket" model in the so-called specificity determining region. This alternative binding mode is modulated via the folding of ER helix 12, a structural element directly C-terminal of the key phosphorylated tyrosine. The present findings provide novel molecular entries for understanding nongenomic ER signaling and targeting the corresponding disease states.

Recovery from temporary endoplasmic reticulum stress in plants relies on the tissue-specific and largely independent roles of bZIP28 and bZIP60, as well as an antagonizing function of BAX-Inhibitor 1 upon the pro-adaptive signaling mediated by bZIP28.

PubMed

Ruberti, Cristina; Lai, YaShiuan; Brandizzi, Federica

2018-01-01

The unfolded protein response (UPR) is an ancient signaling pathway that commits to life-or-death outcomes in response to proteotoxic stress in the endoplasmic reticulum (ER). In plants, the membrane-tethered transcription factor bZIP28 and the ribonuclease-kinase IRE1 along with its splicing target, bZIP60, govern the two cytoprotective UPR signaling pathways known to date. The conserved ER membrane-associated BAX inhibitor 1 (BI1) modulates ER stress-induced programmed cell death through yet-unknown mechanisms. Despite the significance of the UPR for cell homeostasis, in plants the regulatory circuitry underlying ER stress resolution is still largely unmapped. To gain insights into the coordination of plant UPR strategies, we analyzed the functional relationship of the UPR modulators through the analysis of single and higher order mutants of IRE1, bZIP60, bZIP28 and BI1 in experimental conditions causing either temporary or chronic ER stress. We established a functional duality of bZIP28 and bZIP60, as they exert partially independent tissue-specific roles in recovery from ER stress, but redundantly actuate survival strategies in chronic ER stress. We also discovered that BI1 attenuates the pro-survival function of bZIP28 in ER stress resolution and, differently to animal cells, it does not temper the ribonuclease activity of inositol-requiring enzyme 1 (IRE1) under temporary ER stress. Together these findings reveal a functional independence of bZIP28 and bZIP60 in plant UPR, and identify an antagonizing role of BI1 in the pro-adaptive signaling mediated by bZIP28, bringing to light the distinctive complexity of the unfolded protein response (UPR) in plants. © 2017 The Authors The Plant Journal © 2017 John Wiley & Sons Ltd.

Estrogen receptor-beta expression in invasive breast cancer in relation to molecular phenotype: results from the Nurses' Health Study.

PubMed

Marotti, Jonathan D; Collins, Laura C; Hu, Rong; Tamimi, Rulla M

2010-02-01

The expression of estrogen receptor-alpha (ER-alpha) and related genes has emerged as one of the major determinants of molecular classification of invasive breast cancers. Expression of a second ER, estrogen receptor-beta (ER-beta), has not been previously evaluated in a large population-based study. Therefore, we examined ER-beta expression in a large population of women with breast cancer to assess its relationship to molecular categories of invasive breast cancer. We constructed tissue microarrays from paraffin blocks of 3093 breast cancers that developed in women enrolled in the Nurses' Health Study. Tissue microarray sections were immunostained for ER-alpha, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), cytokeratin 5/6, epidermal growth factor receptor (EGFR) and with a monoclonal antibody to ER-beta. Cancers were categorized as luminal A (ER-alpha+ and/or PR+ and HER2-); luminal B (ER-alpha+ and/or PR+ and HER2+); HER2 (ER-alpha- and PR- and HER2+); and basal-like (ER-alpha-, PR-, HER2- and EGFR or cytokeratin 5/6+). The relationship between expression of ER-beta and molecular class of invasive breast cancer was analyzed. Overall, 68% of breast carcinomas were ER-beta+. Expression of ER-beta was significantly associated with expression of ER-alpha (P<0.0001) and PR (P<0.0001), and was inversely related to expression of HER2 (P=0.004), CK5/6 (P=0.02) and EGFR (P=0.006). Among 2170 invasive cancers with complete immunophenotypic data, 73% were luminal A, 5% luminal B, 6 % HER2 and 11% basal-like. ER-beta expression was significantly related to molecular category (P<0.0001) and was more common in luminal A (72% of cases) and B (68% of cases) than in HER2 or basal-like types. However, despite their being defined by the absence of ER-alpha expression, 55% of HER2-type and 60% of basal-like cancers showed expression of ER-beta. The role of ER-beta in the development and progression of breast cancers defined by lack of expression of ER-alpha merits further investigation.

2D Electrostatic Potential Solver for Hall Thruster Simulation

DTIC Science & Technology

2006-07-12

µ(jrBz − jzBr)Br − jrBθ) + µneEz + µ∇zp jr = µ(jzBθ − µ(jrBz − jzBr)Bz) + µneEr + µ∇rp (5) This equation system can be solved to isolate the axial and...Simplification The following simplifications are used to more easily manipulate the equation system . jz = Z3Ez + Z4Er + Z5 jr = R3Ez +R4Er +R5 (10) where, Z5...j−1 ∆r (18) With appropriate boundary conditions, a pentadiagonal linear system of equations of the form Ax=b can be constructed (where x is the

Foothills Parkway Section 8B Final Environmental Report, Volume 4, Appendices E-I

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blasing, T.J.; Cada, G.F.; Carer, M.

1999-07-01

In 1994, Oak Ridge National Laboratory (ORNL) was tasked by the National Park Service (NPS) to prepare an Environmental Report (ER) for Section 8B of the Foothills Parkway in the Great Smoky Mountains National Park (GSMNP). Section 8B represents 27.7 km (14.2 miles) of a total of 115 km (72 miles) of the planned Foothills Parkway and would connect the Cosby community on the east to the incorporated town of Pittman Center to the west. The major deliverables for the project are listed. From August 1995 through October 1996, NPS, GSMNP, and ORNL staff interacted with Federal Highway Administration staffmore » to develop a conceptual design plan for Section 8B with the intent of protecting critical, resources identified during the ER process to the extent possible. In addition, ORNL arranged for bioengineering experts to discuss techniques that might be employed on Section 8B with NPS, GSMNP, and ORNL staff during September 1996. For the purposes of this ER, there are two basic alternatives under consideration: (1) a build alternative and (2) a no-build alternative. Within the build alternative are a number of options including constructing Section 8B with no interchanges, constructing Section 8B with an interchange at SR 416 or U.S. 321, constructing Section 8B with a spur road on Webb Mountain, and considering operation of Section 8B both before and after the operation of Section 8C. The no-build alternative is considered the no-action alternative and is not to construct Section 8B. This volume of the ER consists of Appendices E through I (all ecological survey reports), which are summarized individually in the sections that follow. The following conclusions result from the completion of these surveys and the ER impact analysis: (1) Forest clearing should be limited as much as possible; (2) Disturbed areas should be replanted with native trees; (3) Drainages should be bridged rather than leveled with cut and fill; (4) For areas of steep slopes and potential erosion, bioengineering techniques should be implemented; (5) The Webb Mt. spur road is not recommended. If the spur road is built no grass shoulders should be used (to minimize forest fragmentation impacts); and (6) Transplanting of protected plants should be done when possible. Construction in wetland areas should be avoided and erosion and sedimentation mitigation measures discussed under water resources and aquatic ecology should be implemented.« less

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2013-03-14

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-830-000] J.P. Morgan... Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of J.P...-8659. Dated: March 7, 2013. Nathaniel J. Davis, Sr., Deputy Secretary. [FR Doc. 2013-05859 Filed 3-13...

78 FR 18334 - New York Independent System Operator, Inc.; Notice of Motion for Tariff Waiver and Expedited Action

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-26

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1124-000] New York Independent System Operator, Inc.; Notice of Motion for Tariff Waiver and Expedited Action On March 15, 2013, New York Independent System Operator, Inc. (NYISO) filed a motion for limited tariff waivers of...

77 FR 37035 - O.L.S. Energy-Agnews, Inc.; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-20

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1987-000] O.L.S. Energy-Agnews, Inc.; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of O.L.S...

78 FR 38027 - Novo BioPower LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-25

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1665-000] Novo BioPower LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Novo BioPower...

75 FR 16453 - Nasdaq OMX Commodities Clearing-Finance, LLC; Supplemental Notice That Initial Market-Based Rate...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-914-000] Nasdaq OMX Commodities Clearing--Finance, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization March 25, 2010. This is a supplemental notice in the above-referenced proceeding of Nasdaq OMX...

75 FR 71427 - Domtar Paper Company, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-23

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2020-000] Domtar Paper... proceeding, of Domtar Paper Company, LLC's application for market-based rate authority, with an accompanying... of protests and interventions in lieu of paper, using the FERC Online links at http://www.ferc.gov...

76 FR 38383 - Revised Public Utility Filing; Requirements for Electric Quarterly Reports; Notice of Electric...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-30

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No.: ER02-2001-000] Revised Public Utility Filing; Requirements for Electric Quarterly Reports; Notice of Electric Quarterly Reports Users Group Meeting This notice announces a meeting of the Electric Quarterly Reports (EQR) Users Group to be held Wednesday, July 13, 2011, in the...

76 FR 16405 - Notice of Attendance at PJM INterconnection, L.L.C., Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-23

... INterconnection, L.L.C., Meetings The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission and Commission staff may attend upcoming PJM Interconnection, L.L.C., (PJM...: Docket No. EL05-121, PJM Interconnection, L.L.C. Docket No. ER06-456, PJM Interconnection, L.L.C. Docket...

78 FR 18972 - Alta Wind X, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-28

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1150-000] Alta Wind X, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of Alta Wind X...

75 FR 1052 - Castle Energy Services, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-08

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [ Docket No. ER10-385-000] Castle Energy Services, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization December 30, 2009. This is a supplemental notice in the above-referenced proceeding of Castle Energy Services LLC's...

75 FR 52321 - Dry Lake Wind Power II LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-25

... proceeding, of Dry Lake Wind Power II LLC application for market-based rate authority, with an accompanying... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-1720-000] Dry Lake Wind Power II LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket...

A Low Affinity GCaMP3 Variant (GCaMPer) for Imaging the Endoplasmic Reticulum Calcium Store.

PubMed

Henderson, Mark J; Baldwin, Heather A; Werley, Christopher A; Boccardo, Stefano; Whitaker, Leslie R; Yan, Xiaokang; Holt, Graham T; Schreiter, Eric R; Looger, Loren L; Cohen, Adam E; Kim, Douglas S; Harvey, Brandon K

2015-01-01

Endoplasmic reticulum calcium homeostasis is critical for cellular functions and is disrupted in diverse pathologies including neurodegeneration and cardiovascular disease. Owing to the high concentration of calcium within the ER, studying this subcellular compartment requires tools that are optimized for these conditions. To develop a single-fluorophore genetically encoded calcium indicator for this organelle, we targeted a low affinity variant of GCaMP3 to the ER lumen (GCaMPer (10.19)). A set of viral vectors was constructed to express GCaMPer in human neuroblastoma cells, rat primary cortical neurons, and human induced pluripotent stem cell-derived cardiomyocytes. We observed dynamic changes in GCaMPer (10.19) fluorescence in response to pharmacologic manipulations of the ER calcium store. Additionally, periodic calcium efflux from the ER was observed during spontaneous beating of cardiomyocytes. GCaMPer (10.19) has utility in imaging ER calcium in living cells and providing insight into luminal calcium dynamics under physiologic and pathologic states.

Endoplasmic reticulum Chaperon Tauroursodeoxycholic Acid Alleviates Obesity-Induced Myocardial Contractile Dysfunction

PubMed Central

Ceylan-Isik, Asli F.; Sreejayan, Nair; Ren, Jun

2010-01-01

ER stress is involved in the pathophysiology of obesity although little is known about the role of ER stress on obesity-associated cardiac dysfunction. This study was designed to examine the effect of ER chaperone tauroursodeoxycholic acid (TUDCA) on obesity-induced myocardial dysfunction. Adult lean and ob/ob obese mice were treated TUDCA (50 mg/kg/d, p.o.) or vehicle for 5 wks. Oral glucose tolerance test (OGTT) was performed. Echocardiography, cardiomyocyte contractile and intracellular Ca2+ properties were assessed. Sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) activity and protein expression of intracellular Ca2+ regulatory proteins were measured using 45Ca2+ uptake and Western blot analysis, respectively. Insulin signaling, ER stress markers and HSP90 were evaluated. Our results revealed that chronic TUDCA treatment lower systolic blood pressure and lessened glucose intolerance in obese mice. Obesity led to increased diastolic diameter, cardiac hypertrophy, compromised fractional shortening, cardiomyocyte contractile (peak shortening, maximal velocity of shortening/relengthening, and duration of contraction/relaxation) and intracellular Ca2+ properties, all of which were significantly attenuated by TUDCA. TUDCA reconciled obesity-associated decreased in SERCA activity and expression, and increase in serine phosphorylation of IRS, total and phosphorylated cJun, ER stress markers Bip, peIF2α and pPERK. Obesity-induced changes in phospholamban and HSP90 were unaffected by TUDCA. In vitro finding revealed that TUDCA ablated palmitic acid-induced cardiomyocyte contractile dysfunction. In summary, these data depicted a pivotal role of ER stress in obesity-associated cardiac contractile dysfunction, suggesting the therapeutic potential of ER stress as a target in the management of cardiac dysfunction in obesity. PMID:21035453

Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases

PubMed Central

Araki, Kazutaka; Iemura, Shun-ichiro; Kamiya, Yukiko; Ron, David; Kato, Koichi; Natsume, Tohru

2013-01-01

Ero1-α and endoplasmic reticulum (ER) oxidoreductases of the protein disulfide isomerase (PDI) family promote the efficient introduction of disulfide bonds into nascent polypeptides in the ER. However, the hierarchy of electron transfer among these oxidoreductases is poorly understood. In this paper, Ero1-α–associated oxidoreductases were identified by proteomic analysis and further confirmed by surface plasmon resonance. Ero1-α and PDI were found to constitute a regulatory hub, whereby PDI induced conformational flexibility in an Ero1-α shuttle cysteine (Cys99) facilitated intramolecular electron transfer to the active site. In isolation, Ero1-α also oxidized ERp46, ERp57, and P5; however, kinetic measurements and redox equilibrium analysis revealed that PDI preferentially oxidized other oxidoreductases. PDI accepted electrons from the other oxidoreductases via its a′ domain, bypassing the a domain, which serves as the electron acceptor from reduced glutathione. These observations provide an integrated picture of the hierarchy of cooperative redox interactions among ER oxidoreductases in mammalian cells. PMID:24043701

78 FR 25137 - Radio Experimentation and Market Trials-Streamlining Rules

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-29

...This document revises and streamlines the Commission rules to modernize the Experimental Radio Service (ERS). The rules adopted in the Report and Order updates the ERS to a more flexible framework to keep pace with the speed of modern technological change while continuing to provide an environment where creativity can thrive. To accomplish this transition, the Commission created three new types of ERS licenses--the program license, the medical testing license, and the compliance testing license--to benefit the development of new technologies, expedite their introduction to the marketplace, and unleash the full power of innovators to keep the United States at the forefront of the communications industry. The Commission's actions also modify the market trial rules to eliminate confusion and more clearly articulate its policies with respect to marketing products prior to equipment certification. The Commission believes that these actions will remove regulatory barriers to experimentation, thereby permitting institutions to move from concept to experimentation to finished product more rapidly and to more quickly implement creative problem- solving methodologies.

An uncleaved signal peptide directs the Malus xiaojinensis iron transporter protein Mx IRT1 into the ER for the PM secretory pathway.

PubMed

Zhang, Peng; Tan, Song; Berry, James O; Li, Peng; Ren, Na; Li, Shuang; Yang, Guang; Wang, Wei-Bing; Qi, Xiao-Ting; Yin, Li-Ping

2014-11-07

Malus xiaojinensis iron-regulated transporter 1 (Mx IRT1) is a highly effective inducible iron transporter in the iron efficient plant Malus xiaojinensis. As a multi-pass integral plasma membrane (PM) protein, Mx IRT1 is predicted to consist of eight transmembrane domains, with a putative N-terminal signal peptide (SP) of 1-29 amino acids. To explore the role of the putative SP, constructs expressing Mx IRT1 (with an intact SP) and Mx DsIRT1 (with a deleted SP) were prepared for expression in Arabidopsis and in yeast. Mx IRT1 could rescue the iron-deficiency phenotype of an Arabidopsis irt1 mutant, and complement the iron-limited growth defect of the yeast mutant DEY 1453 (fet3fet4). Furthermore, fluorescence analysis indicated that a chimeric Mx IRT1-eGFP (enhanced Green Fluorescent Protein) construct was translocated into the ER (Endoplasmic reticulum) for the PM sorting pathway. In contrast, the SP-deleted Mx DsIRT1 could not rescue either of the mutant phenotypes, nor direct transport of the GFP signal into the ER. Interestingly, immunoblot analysis indicated that the SP was not cleaved from the mature protein following transport into the ER. Taken together, data presented here provides strong evidence that an uncleaved SP determines ER-targeting of Mx IRT1 during the initial sorting stage, thereby enabling the subsequent transport and integration of this protein into the PM for its crucial role in iron uptake.

Endoplasmic reticulum stress inhibits expression of genes involved in thyroid hormone synthesis and their key transcriptional regulators in FRTL-5 thyrocytes

PubMed Central

Wen, Gaiping; Eder, Klaus

2017-01-01

Endoplasmic reticulum (ER) stress is characterized by the accumulation of misfolded proteins due to an impairment of ER quality control pathways leading to the activation of a defense system, called unfolded protein response (UPR). While thyrocytes are supposed to be highly susceptible to environmental conditions that cause ER stress due to the synthesis of large amounts of secretory proteins required for thyroid hormone synthesis, systematic investigations on the effect of ER stress on expression of key genes of thyroid hormone synthesis and their transcriptional regulators are lacking. Since the aim of the ER stress-induced UPR is to restore ER homeostasis and to facilitate cell survival through transient shutdown of ribosomal protein translation, we hypothesized that the expression of genes involved in thyroid hormone synthesis and their transcriptional regulators, all of which are not essential for cell survival, are down-regulated in thyrocytes during ER stress, while sterol regulatory element-binding proteins (SREBPs) are activated during ER stress in thyrocytes. Treatment of FRTL-5 thyrocytes with the ER stress inducer tunicamycin (TM) dose-dependently increased the mRNA and/or protein levels of known UPR target genes, stimulated phosphorylation of the ER stress sensor protein kinase RNA-like ER kinase (PERK) and of the PERK target protein eukaryotic initiation factor 2α (eIF2α) and caused splicing of the ER stress-sensitive transcription factor X-box binding protein (XBP-1) (P < 0.05). The mRNA levels and/or protein levels of genes involved in thyroid hormone synthesis, sodium/iodide symporter (NIS), thyroid peroxidase (TPO) and thyroglobulin (TG), their transcriptional regulators and thyrotropin (TSH) receptor and the uptake of Na125I were reduced at the highest concentration of TM tested (0.1 μg/mL; P < 0.05). Proteolytic activation of the SREBP-1c pathway was not observed in FRTL-5 cells treated with TM, whereas TM reduced proteolytic activation of the SREBP-2 pathway at 0.1 μg TM/mL (P < 0.05). In conclusion, the expression of key genes involved in thyroid hormone synthesis and their critical regulators and of the TSH receptor as well as the uptake of iodide is attenuated in thyrocytes during mild ER stress. Down-regulation of NIS, TPO and TG during ER stress is likely the consequence of impaired TSH/TSHR signaling in concert with reduced expression of critical transcriptional regulators of these genes. PMID:29095946

Endoplasmic reticulum stress inhibits expression of genes involved in thyroid hormone synthesis and their key transcriptional regulators in FRTL-5 thyrocytes.

PubMed

Wen, Gaiping; Ringseis, Robert; Eder, Klaus

2017-01-01

Endoplasmic reticulum (ER) stress is characterized by the accumulation of misfolded proteins due to an impairment of ER quality control pathways leading to the activation of a defense system, called unfolded protein response (UPR). While thyrocytes are supposed to be highly susceptible to environmental conditions that cause ER stress due to the synthesis of large amounts of secretory proteins required for thyroid hormone synthesis, systematic investigations on the effect of ER stress on expression of key genes of thyroid hormone synthesis and their transcriptional regulators are lacking. Since the aim of the ER stress-induced UPR is to restore ER homeostasis and to facilitate cell survival through transient shutdown of ribosomal protein translation, we hypothesized that the expression of genes involved in thyroid hormone synthesis and their transcriptional regulators, all of which are not essential for cell survival, are down-regulated in thyrocytes during ER stress, while sterol regulatory element-binding proteins (SREBPs) are activated during ER stress in thyrocytes. Treatment of FRTL-5 thyrocytes with the ER stress inducer tunicamycin (TM) dose-dependently increased the mRNA and/or protein levels of known UPR target genes, stimulated phosphorylation of the ER stress sensor protein kinase RNA-like ER kinase (PERK) and of the PERK target protein eukaryotic initiation factor 2α (eIF2α) and caused splicing of the ER stress-sensitive transcription factor X-box binding protein (XBP-1) (P < 0.05). The mRNA levels and/or protein levels of genes involved in thyroid hormone synthesis, sodium/iodide symporter (NIS), thyroid peroxidase (TPO) and thyroglobulin (TG), their transcriptional regulators and thyrotropin (TSH) receptor and the uptake of Na125I were reduced at the highest concentration of TM tested (0.1 μg/mL; P < 0.05). Proteolytic activation of the SREBP-1c pathway was not observed in FRTL-5 cells treated with TM, whereas TM reduced proteolytic activation of the SREBP-2 pathway at 0.1 μg TM/mL (P < 0.05). In conclusion, the expression of key genes involved in thyroid hormone synthesis and their critical regulators and of the TSH receptor as well as the uptake of iodide is attenuated in thyrocytes during mild ER stress. Down-regulation of NIS, TPO and TG during ER stress is likely the consequence of impaired TSH/TSHR signaling in concert with reduced expression of critical transcriptional regulators of these genes.

Plant nitrogen regulatory P-PII genes

DOEpatents

Coruzzi, Gloria M.; Lam, Hon-Ming; Hsieh, Ming-Hsiun

2001-01-01

The present invention generally relates to plant nitrogen regulatory PII gene (hereinafter P-PII gene), a gene involved in regulating plant nitrogen metabolism. The invention provides P-PII nucleotide sequences, expression constructs comprising said nucleotide sequences, and host cells and plants having said constructs and, optionally expressing the P-PII gene from said constructs. The invention also provides substantially pure P-PII proteins. The P-PII nucleotide sequences and constructs of the

Survey Response Styles, Acculturation, and Culture Among a Sample of Mexican American Adults.

PubMed

Davis, Rachel E; Resnicow, Ken; Couper, Mick P

2011-10-01

A number of studies have investigated use of extreme (ERS) and acquiescent (ARS) response styles across cultural groups. However, due to within-group heterogeneity, it is important to also examine use of response styles, acculturation, and endorsement of cultural variables at the individual level. This study explores relationships between acculturation, six Mexican cultural factors, ERS, and ARS among a sample of 288 Mexican American telephone survey respondents. Three aspects of acculturation were assessed: Spanish use, the importance of preserving Mexican culture, and interaction with Mexican Americans versus Anglos. These variables were hypothesized to positively associate with ERS and ARS. Participants with higher Spanish use did utilize more ERS and ARS; however, value for preserving Mexican culture and interaction with Mexican Americans were not associated with response style use. In analyses of cultural factors, endorsement of familismo and simpatia were related to more frequent ERS and ARS, machismo was associated with lower ERS among men, and la mujer was related to higher ERS among women. Caballerismo was marginally associated with utilization of ERS among men. No association was found between la mujer abnegada and ERS among women. Relationships between male gender roles and ARS were nonsignificant. Relationships between female gender roles and ARS were mixed but trended in the positive direction. Overall, these findings suggest that Mexican American respondents vary in their use of response styles by acculturation and cultural factors. This usage may be specifically influenced by participants' valuing of and engagement with constructs directly associated with social behavior.

The Role of Emotion Regulation in Autism Spectrum Disorder RH: Emotion Regulation in ASD

PubMed Central

Mazefsky, Carla A.; Herrington, John; Siegel, Matthew; Scarpa, Angela; Maddox, Brenna B.; Scahill, Lawrence; White, Susan W.

2013-01-01

Objective Autism spectrum disorder (ASD) is associated with amplified emotional responses and poor emotional control, but little is known about the underlying mechanisms. This paper provides a conceptual and methodological framework for understanding compromised emotion regulation (ER) in ASD. Method After defining ER and related constructs, methods to study ER were reviewed with special consideration on how to apply these approaches to ASD. Against the backdrop of cognitive characteristics in ASD and existing ER theories, available research was examined to identify likely contributors to emotional dysregulation in ASD. Results Little is currently known about ER in youth with ASD. Some mechanisms that contribute to poor ER in ASD may be shared with other clinical populations (e.g., physiological arousal, degree of negative and positive affect, alterations in the amygdala and prefrontal cortex), whereas other mechanisms may be more unique to ASD (e.g., differences in information processing/perception, cognitive factors (e.g., rigidity), less goal-directed behavior and more disorganized emotion in ASD). Conclusions Although assignment of concomitant psychiatric diagnoses is warranted in some cases, poor ER may be inherent in ASD and may provide a more parsimonious conceptualization for the many associated socio-emotional and behavioral problems in this population. Further study of ER in youth with ASD may identify meaningful subgroups of patients and lead to more effective individualized treatments. PMID:23800481

NHERF1, a novel GPER associated protein, increases stability and activation of GPER in ER-positive breast cancer

PubMed Central

Xiong, Ying; Wang, Yan; Zheng, Junfang; Zhao, Yuan; Tao, Tao; Wang, Qiqi; Liu, Hua; Wang, Songlin; Jiang, Wen G.; He, Junqi

2016-01-01

G protein-coupled estrogen receptor (GPER) plays an important role in mediating the effects of estradiol. High levels of GPER have been implicated to associate with the malignant progress of invasive breast cancer (IBC). However, the mechanisms by which GPER protein levels were regulated remain unclear. In this study, PDZ protein Na+/H+ exchanger regulatory factor (NHERF1) was found to interact with GPER in breast cancer cells. This interaction was mediated by the PDZ2 domain of NHERF1 and the carboxyl terminal PDZ binding motif of GPER. NHERF1 was demonstrated to facilitate GPER expression at post-transcriptional level and improve GPER protein stability by inhibiting the receptor degradation via ubiquitin-proteasome pathway in a GPER/NHERF1 interaction-dependent manner. In addition, GPER protein levels are positively associated with NHERF1 protein levels in a panel of estrogen receptor (ER)-positive breast cancer cells. Furthermore, analysis of clinical IBC data from The Cancer Genome Atlas (TCGA) showed no significant difference in GPER mRNA levels between ER-positive IBC and normal breast tissues. However, gene set enrichment analysis (GSEA) showed that GPER signaling is ultra-activated in ER-positive IBC when compared with normal and its activation is positively associated with NHERF1 mRNA levels. Taken together, our findings identify NHERF1 as a new binding partner for GPER and its overexpression promotes protein stability and activation of GPER in ER-positive IBC. Our data indicate that regulation of GPER stability by NHERF1 may contribute to GPER-mediated carcinogenesis in ER-positive IBC. PMID:27448983

NHERF1, a novel GPER associated protein, increases stability and activation of GPER in ER-positive breast cancer.

PubMed

Meng, Ran; Qin, Qiong; Xiong, Ying; Wang, Yan; Zheng, Junfang; Zhao, Yuan; Tao, Tao; Wang, Qiqi; Liu, Hua; Wang, Songlin; Jiang, Wen G; He, Junqi

2016-08-23

G protein-coupled estrogen receptor (GPER) plays an important role in mediating the effects of estradiol. High levels of GPER have been implicated to associate with the malignant progress of invasive breast cancer (IBC). However, the mechanisms by which GPER protein levels were regulated remain unclear. In this study, PDZ protein Na+/H+ exchanger regulatory factor (NHERF1) was found to interact with GPER in breast cancer cells. This interaction was mediated by the PDZ2 domain of NHERF1 and the carboxyl terminal PDZ binding motif of GPER. NHERF1 was demonstrated to facilitate GPER expression at post-transcriptional level and improve GPER protein stability by inhibiting the receptor degradation via ubiquitin-proteasome pathway in a GPER/NHERF1 interaction-dependent manner. In addition, GPER protein levels are positively associated with NHERF1 protein levels in a panel of estrogen receptor (ER)-positive breast cancer cells. Furthermore, analysis of clinical IBC data from The Cancer Genome Atlas (TCGA) showed no significant difference in GPER mRNA levels between ER-positive IBC and normal breast tissues. However, gene set enrichment analysis (GSEA) showed that GPER signaling is ultra-activated in ER-positive IBC when compared with normal and its activation is positively associated with NHERF1 mRNA levels. Taken together, our findings identify NHERF1 as a new binding partner for GPER and its overexpression promotes protein stability and activation of GPER in ER-positive IBC. Our data indicate that regulation of GPER stability by NHERF1 may contribute to GPER-mediated carcinogenesis in ER-positive IBC.

Identification of differentially expressed genes in human breast cancer cells induced by 4-hydroxyltamoxifen and elucidation of their pathophysiological relevance and mechanisms

PubMed Central

Fang, Qi; Yao, Shuang; Luo, Guanghua; Zhang, Xiaoying

2018-01-01

While tamoxifen (TAM) is used for treating estrogen receptor (ER)a-positive breast cancer patients, its anti-breast cancer mechanisms are not completely elucidated. This study aimed to examine effects of 4-hydroxyltamoxifen (4-OH-TAM) on ER-positive (ER+) breast cancer MCF-7 cell growth and gene expression profiles. MCF-7 cell growth was inhibited by 4-OH-TAM dose-dependently with IC50 of 29 μM. 332 genes were up-regulated while 320 genes were down-regulated. The mRNA levels of up-regulated genes including STAT1, STAT2, EIF2AK2, TGM2, DDX58, PARP9, SASH1, RBL2 and USP18 as well as down-regulated genes including CCDN1, S100A9, S100A8, ANXA1 and PGR were confirmed by quantitative real-time PCR (qRT-PCR). In human breast tumor tissues, mRNA levels of EIF2Ak2, USP18, DDX58, RBL2, STAT2, PGR, S1000A9, and CCND1 were significantly higher in ER+- than in ER--breast cancer tissues. The mRNA levels of EIF2AK2, TGM2, USP18, DDX58, PARP9, STAT2, STAT1, PGR and CCND1 were all significantly higher in ER+-tumor tissues than in their corresponding tumor-adjacent tissues. These genes, except PGR and CCND1 which were down-regulated, were also up-regulated in ER+ MCF-7 cells by 4-OH-TAM. Total 14 genes mentioned above are involved in regulation of cell proliferation, apoptosis, cell cycles, and estrogen and interferon signal pathways. Bioinformatics analysis also revealed other novel and important regulatory factors that are associated with these genes and involved in the mentioned functional processes. This study has paved a foundation for elucidating TAM anti-breast cancer mechanisms in E2/ER-dependent and independent pathways. PMID:29416786

Identification of differentially expressed genes in human breast cancer cells induced by 4-hydroxyltamoxifen and elucidation of their pathophysiological relevance and mechanisms.

PubMed

Fang, Qi; Yao, Shuang; Luo, Guanghua; Zhang, Xiaoying

2018-01-05

While tamoxifen (TAM) is used for treating estrogen receptor (ER)a-positive breast cancer patients, its anti-breast cancer mechanisms are not completely elucidated. This study aimed to examine effects of 4-hydroxyltamoxifen (4-OH-TAM) on ER-positive (ER + ) breast cancer MCF-7 cell growth and gene expression profiles. MCF-7 cell growth was inhibited by 4-OH-TAM dose-dependently with IC 50 of 29 μM. 332 genes were up-regulated while 320 genes were down-regulated. The mRNA levels of up-regulated genes including STAT1, STAT2, EIF2AK2, TGM2, DDX58, PARP9, SASH1, RBL2 and USP18 as well as down-regulated genes including CCDN1, S100A9, S100A8, ANXA1 and PGR were confirmed by quantitative real-time PCR (qRT-PCR). In human breast tumor tissues, mRNA levels of EIF2Ak2, USP18, DDX58, RBL2, STAT2, PGR, S1000A9, and CCND1 were significantly higher in ER + - than in ER - -breast cancer tissues. The mRNA levels of EIF2AK2, TGM2, USP18, DDX58, PARP9, STAT2, STAT1, PGR and CCND1 were all significantly higher in ER + -tumor tissues than in their corresponding tumor-adjacent tissues. These genes, except PGR and CCND1 which were down-regulated, were also up-regulated in ER + MCF-7 cells by 4-OH-TAM. Total 14 genes mentioned above are involved in regulation of cell proliferation, apoptosis, cell cycles, and estrogen and interferon signal pathways. Bioinformatics analysis also revealed other novel and important regulatory factors that are associated with these genes and involved in the mentioned functional processes. This study has paved a foundation for elucidating TAM anti-breast cancer mechanisms in E2/ER-dependent and independent pathways.

Investigating the Role of NOS2 in Breast Cancer | Center for Cancer Research

Cancer.gov

Inducible nitric oxide synthase (NOS2) is often elevated in breast tumors that lack expression of the estrogen receptor (ER) and predicts a poor prognosis for patients with these tumors. However, it is unclear whether NOS2 directly contributes to ER-negative breast cancer aggressiveness or how NOS2 expression is controlled within the tumor microenvironment. To tease apart the regulatory pathways upstream and downstream of NOS2, David Wink, Jr., Ph.D., Senior Investigator in CCR’s Radiation Biology Branch, along with colleagues from CCR’s Pediatric Oncology Branch, Laboratory of Human Carcinogenesis, and Laboratory of Experimental Immunology and from the Prostate Cancer Institute in Ireland, carried out studies in cell culture and mouse models.

Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis

PubMed Central

Sanchez-Alvarez, Miguel; Zhang, Qifeng; Finger, Fabian; Wakelam, Michael J. O.; Bakal, Chris

2015-01-01

We show that phospholipid anabolism does not occur uniformly during the metazoan cell cycle. Transition to S-phase is required for optimal mobilization of lipid precursors, synthesis of specific phospholipid species and endoplasmic reticulum (ER) homeostasis. Average changes observed in whole-cell phospholipid composition, and total ER lipid content, upon stimulation of cell growth can be explained by the cell cycle distribution of the population. TORC1 promotes phospholipid anabolism by slowing S/G2 progression. The cell cycle stage-specific nature of lipid biogenesis is dependent on p53. We propose that coupling lipid metabolism to cell cycle progression is a means by which cells have evolved to coordinate proliferation with cell and organelle growth. PMID:26333836

Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis.

PubMed

Sanchez-Alvarez, Miguel; Zhang, Qifeng; Finger, Fabian; Wakelam, Michael J O; Bakal, Chris

2015-09-01

We show that phospholipid anabolism does not occur uniformly during the metazoan cell cycle. Transition to S-phase is required for optimal mobilization of lipid precursors, synthesis of specific phospholipid species and endoplasmic reticulum (ER) homeostasis. Average changes observed in whole-cell phospholipid composition, and total ER lipid content, upon stimulation of cell growth can be explained by the cell cycle distribution of the population. TORC1 promotes phospholipid anabolism by slowing S/G2 progression. The cell cycle stage-specific nature of lipid biogenesis is dependent on p53. We propose that coupling lipid metabolism to cell cycle progression is a means by which cells have evolved to coordinate proliferation with cell and organelle growth. © 2015 The Authors.

75 FR 76727 - Red Mesa Wind, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-09

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2192-000] Red Mesa Wind, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization December 1, 2010. This is a supplemental notice in the above-referenced proceeding of Red Mesa Wind, LLC's application for...

77 FR 21762 - ReEnergy Livermore Falls LLC; Supplemental Notice That Revised Market-Based Rate Tariff Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-11

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-1432-000] ReEnergy Livermore Falls LLC; Supplemental Notice That Revised Market-Based Rate Tariff Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of ReEnergy Livermore Falls LLC's tariff...

75 FR 8325 - E.ON U.S. LLC; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-24

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-295-000] E.ON U.S. LLC; Notice of Filing February 17, 2010. Take notice that, on February 16, 2009, E.ON U.S. LLC filed to... interventions in lieu of paper using the ``eFiling'' link at http://www.ferc.gov . Persons unable to file...

75 FR 52938 - E. I. du Pont de Nemours and Company; Notice of Filing

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-30

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER10-1810-001] E. I. du Pont de Nemours and Company; Notice of Filing August 20, 2010. Take notice that on August 20, 2010, E. I... protests and interventions in lieu of paper using the ``eFiling'' link at http://www.ferc.gov . Persons...

77 FR 41399 - EC&R O&M, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-13

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER12-2145-000] EC&R O&M, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of EC&R O&M, LLC's application...

78 FR 28832 - Fish Lake Power LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-16

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER13-1270-000] Fish Lake Power LLC; Supplemental Notice That Initial Market- Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding of Fish Lake Power LLC's application for market-based rate...